gene id gene name description GO_id GO_term KO_ID KO_Description kegg_id kegg_term locus E11_count E12_count E142_count NC1_count NC2_count NC42_count E11_FPKM E12_FPKM E142_FPKM NC1_FPKM NC2_FPKM NC42_FPKM Group2 Group1 log2FC Pvalue Qvalue updown ENSG00000198919 DZIP3 DAZ interacting zinc finger protein 3 [Source:HGNC Symbol;Acc:HGNC:30938] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0032182|GO:0003676|GO:0043169|GO:0019899|GO:0005737|GO:0019787|GO:0019538|GO:0046872|GO:0003723|GO:0043412|GO:0030163|GO:0004842|GO:0043130|GO:0044265|GO:0036211|GO:0019902|GO:0006508|GO:0044267|GO:0044257|GO:0061630|GO:0010498|GO:0051603|GO:0046914|GO:0044822|GO:0031593|GO:0006464|GO:0019941|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0042787|GO:0016567|GO:0000209 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|ligase activity|intracellular|protein binding|transferase activity|ubiquitin-like protein binding|nucleic acid binding|cation binding|enzyme binding|cytoplasm|ubiquitin-like protein transferase activity|protein metabolic process|metal ion binding|RNA binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|ubiquitin binding|cellular macromolecule catabolic process|protein modification process|phosphatase binding|proteolysis|cellular protein metabolic process|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|proteolysis involved in cellular protein catabolic process|transition metal ion binding|poly(A) RNA binding|polyubiquitin binding|cellular protein modification process|modification-dependent protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 3:108589682-108694846 36 39 46 1148 1281 1149 0.298749505869514 0.294138339481649 0.34417217779154 8.53575578373868 8.72206845975414 8.93616984010473 0.312353341047568 8.73133136119918 -4.80495078735398 7.03022561526259e-82 2.09880355518049e-77 DOWN ENSG00000187164 SHTN1 shootin 1 [Source:HGNC Symbol;Acc:HGNC:29319] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0016049|GO:0048870|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0030427|GO:0045927|GO:0040008|GO:0009605|GO:0031252|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0051272|GO:0006935|GO:0045595|GO:0048468|GO:0043025|GO:0051130|GO:0007275|GO:0032535|GO:0030307|GO:0005874|GO:0051128|GO:2000147|GO:0030426|GO:0022607|GO:0045597|GO:0005737|GO:0006928|GO:0032403|GO:0060327|GO:0043005|GO:0030027|GO:0043204|GO:0048639|GO:0036477|GO:0005875|GO:0007163|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0048638|GO:0008092|GO:0030030|GO:0048869|GO:0030029|GO:2000145|GO:0032878|GO:0001558|GO:0010256|GO:0006996|GO:0060560|GO:0000902|GO:0031175|GO:0031344|GO:2000114|GO:0007166|GO:0030424|GO:0007010|GO:0010720|GO:0030048|GO:0003779|GO:0044295|GO:0031346|GO:0000904|GO:0030334|GO:0001764|GO:0050769|GO:0030010|GO:0030031|GO:0008361|GO:0048471|GO:0061163|GO:0022604|GO:0030175|GO:0030036|GO:0051015|GO:0035556|GO:0006929|GO:0030516|GO:0019894|GO:0032990|GO:0007399|GO:0007029|GO:0097485|GO:0010770|GO:0030154|GO:0048858|GO:0030335|GO:0005856|GO:1990138|GO:0051960|GO:0045773|GO:0048666|GO:0030182|GO:0007411|GO:2001222|GO:0010975|GO:0070252|GO:0006930|GO:0010769|GO:0061564|GO:2001224|GO:0015630|GO:0050772|GO:0022008|GO:0048667|GO:0007264|GO:0007015|GO:0038007|GO:0050767|GO:0048812|GO:0010976|GO:0048675|GO:0045666|GO:0007265|GO:0007409|GO:0048699|GO:0061572|GO:0050770|GO:0045664|GO:0007266|GO:0032488|GO:0061573 locomotion|developmental process|growth|macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|cell growth|cell motility|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|site of polarized growth|positive regulation of growth|regulation of growth|response to external stimulus|cell leading edge|regulation of developmental process|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|positive regulation of cellular component movement|chemotaxis|regulation of cell differentiation|cell development|neuronal cell body|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component size|positive regulation of cell growth|microtubule|regulation of cellular component organization|positive regulation of cell motility|growth cone|cellular component assembly|positive regulation of cell differentiation|cytoplasm|movement of cell or subcellular component|protein complex binding|cytoplasmic actin-based contraction involved in cell motility|neuron projection|lamellipodium|perikaryon|positive regulation of developmental growth|somatodendritic compartment|microtubule associated complex|establishment or maintenance of cell polarity|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|regulation of developmental growth|cytoskeletal protein binding|cell projection organization|cellular developmental process|actin filament-based process|regulation of cell motility|regulation of establishment or maintenance of cell polarity|regulation of cell growth|endomembrane system organization|organelle organization|developmental growth involved in morphogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|regulation of establishment of cell polarity|cell surface receptor signaling pathway|axon|cytoskeleton organization|positive regulation of cell development|actin filament-based movement|actin binding|axonal growth cone|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|regulation of cell migration|neuron migration|positive regulation of neurogenesis|establishment of cell polarity|cell projection assembly|regulation of cell size|perinuclear region of cytoplasm|endoplasmic reticulum polarization|regulation of cell morphogenesis|filopodium|actin cytoskeleton organization|actin filament binding|intracellular signal transduction|substrate-dependent cell migration|regulation of axon extension|kinesin binding|cell part morphogenesis|nervous system development|endoplasmic reticulum organization|neuron projection guidance|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|cytoskeleton|neuron projection extension|regulation of nervous system development|positive regulation of axon extension|neuron development|neuron differentiation|axon guidance|regulation of neuron migration|regulation of neuron projection development|actin-mediated cell contraction|substrate-dependent cell migration, cell extension|regulation of cell morphogenesis involved in differentiation|axon development|positive regulation of neuron migration|microtubule cytoskeleton|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|actin filament organization|netrin-activated signaling pathway|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|axon extension|positive regulation of neuron differentiation|Ras protein signal transduction|axonogenesis|generation of neurons|actin filament bundle organization|regulation of axonogenesis|regulation of neuron differentiation|Rho protein signal transduction|Cdc42 protein signal transduction|actin filament bundle retrograde transport - - - - 10:116881482-117126586 22 15 30 829 953 858 0.112703117454268 0.0698392204406078 0.138562776039084 3.80511033895095 4.00567555138154 4.1193722281194 0.107035037977987 3.9767193728173 -5.21542371227702 5.60403073418983e-72 8.36513667692516e-68 DOWN ENSG00000101849 TBL1X transducin (beta)-like 1X-linked [Source:HGNC Symbol;Acc:HGNC:11585] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0044255|GO:0003712|GO:0006725|GO:0042393|GO:0008013|GO:0008022|GO:1901360|GO:0016570|GO:0003676|GO:0050877|GO:0034641|GO:0005874|GO:0044281|GO:0031325|GO:0046483|GO:0043231|GO:0017053|GO:0009890|GO:0019904|GO:0006139|GO:0007154|GO:0006629|GO:0007165|GO:0008134|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0007166|GO:0043412|GO:0030163|GO:0010629|GO:0051252|GO:0006325|GO:0044265|GO:0010628|GO:0036211|GO:0007600|GO:0031981|GO:0006508|GO:0005654|GO:0005876|GO:0044267|GO:0010467|GO:0000118|GO:0031328|GO:0009059|GO:0016070|GO:0005856|GO:0010557|GO:0016575|GO:0005634|GO:0005819|GO:0016055|GO:0044257|GO:0000975|GO:0045893|GO:0010498|GO:0050954|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0051603|GO:0015630|GO:0016568|GO:0007219|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0007605|GO:0006357|GO:0019941|GO:1903506|GO:0044212|GO:0060070|GO:0000122|GO:0043161|GO:0006511|GO:0006476 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cellular lipid metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|histone binding|beta-catenin binding|protein C-terminus binding|organic cyclic compound metabolic process|histone modification|nucleic acid binding|neurological system process|cellular nitrogen compound metabolic process|microtubule|small molecule metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcriptional repressor complex|negative regulation of biosynthetic process|protein domain specific binding|nucleobase-containing compound metabolic process|cell communication|lipid metabolic process|signal transduction|transcription factor binding|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|cell surface receptor signaling pathway|macromolecule modification|protein catabolic process|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|sensory perception|nuclear lumen|proteolysis|nucleoplasm|spindle microtubule|cellular protein metabolic process|gene expression|histone deacetylase complex|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|spindle|Wnt signaling pathway|cellular protein catabolic process|regulatory region DNA binding|positive regulation of transcription, DNA-templated|proteasomal protein catabolic process|sensory perception of mechanical stimulus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|chromatin modification|Notch signaling pathway|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|sensory perception of sound|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|canonical Wnt signaling pathway|negative regulation of transcription from RNA polymerase II promoter|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|protein deacetylation K04508 transducin (beta)-like 1[-] hsa04310 Wnt signaling pathway - Homo sapiens (human) X:9463295-9719743 88 87 151 2327 2512 2335 0.446127612931564 0.400847538560662 0.690192233373873 10.5699329789057 10.4487839368594 11.0941502243304 0.5123891282887 10.7042890466985 -4.3848053029678 4.45168572419058e-69 4.43002085366618e-65 DOWN ENSG00000177565 TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 [Source:HGNC Symbol;Acc:HGNC:29529] GO:0032502|GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0047485|GO:0044255|GO:0003712|GO:0006725|GO:0009888|GO:0042393|GO:0008013|GO:1901360|GO:0009991|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0034641|GO:0005874|GO:0044281|GO:0019637|GO:0031325|GO:0046483|GO:0043231|GO:0017053|GO:0035264|GO:0009890|GO:0006139|GO:0055086|GO:0007154|GO:0002021|GO:0006629|GO:0007165|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0090207|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0046486|GO:0007166|GO:0043412|GO:0030163|GO:0010629|GO:0019693|GO:0016042|GO:0051252|GO:0006325|GO:0044265|GO:0010628|GO:0036211|GO:0006638|GO:0031981|GO:0006508|GO:0005654|GO:0005876|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0000118|GO:0019216|GO:0031328|GO:0009059|GO:0030154|GO:0061448|GO:0016070|GO:0031667|GO:0005856|GO:0010557|GO:0016575|GO:0005634|GO:0005819|GO:0060612|GO:0016055|GO:0044257|GO:0000975|GO:0045893|GO:0045444|GO:0060613|GO:0010498|GO:0009259|GO:0045892|GO:0009117|GO:0032774|GO:2001141|GO:1902679|GO:0051603|GO:0015630|GO:0006163|GO:0016568|GO:0006639|GO:0007219|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:0019941|GO:1903506|GO:0044212|GO:0060070|GO:0050872|GO:0009187|GO:0000122|GO:0006641|GO:0043161|GO:0006511|GO:0046058|GO:0030814|GO:0006476 developmental process|growth|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|protein N-terminus binding|cellular lipid metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|histone binding|beta-catenin binding|organic cyclic compound metabolic process|response to extracellular stimulus|multicellular organism development|histone modification|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|microtubule|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcriptional repressor complex|multicellular organism growth|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|response to dietary excess|lipid metabolic process|signal transduction|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of triglyceride metabolic process|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|glycerolipid metabolic process|cell surface receptor signaling pathway|macromolecule modification|protein catabolic process|negative regulation of gene expression|ribose phosphate metabolic process|lipid catabolic process|regulation of RNA metabolic process|chromatin organization|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|neutral lipid metabolic process|nuclear lumen|proteolysis|nucleoplasm|spindle microtubule|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|histone deacetylase complex|regulation of lipid metabolic process|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|connective tissue development|RNA metabolic process|response to nutrient levels|cytoskeleton|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|spindle|adipose tissue development|Wnt signaling pathway|cellular protein catabolic process|regulatory region DNA binding|positive regulation of transcription, DNA-templated|fat cell differentiation|fat pad development|proteasomal protein catabolic process|ribonucleotide metabolic process|negative regulation of transcription, DNA-templated|nucleotide metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|purine nucleotide metabolic process|chromatin modification|acylglycerol metabolic process|Notch signaling pathway|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|canonical Wnt signaling pathway|white fat cell differentiation|cyclic nucleotide metabolic process|negative regulation of transcription from RNA polymerase II promoter|triglyceride metabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|cAMP metabolic process|regulation of cAMP metabolic process|protein deacetylation K04508 transducin (beta)-like 1[-] hsa04310 Wnt signaling pathway - Homo sapiens (human) 3:177019355-177197396 153 200 226 2724 3236 2882 0.466637868675289 0.554368146243 0.621456442078853 7.44378078487999 8.09776765322307 8.23780855748373 0.547487485665714 7.92645233186226 -3.85577740522526 2.7229766170714e-66 2.03229359815124e-62 DOWN ENSG00000133030 MPRIP myosin phosphatase Rho interacting protein [Source:HGNC Symbol;Acc:HGNC:30321] GO:0005623|GO:0030054|GO:0005488|GO:0030055|GO:0043229|GO:0005622|GO:0005515|GO:0005924|GO:0005912|GO:0005737|GO:0008092|GO:0003779|GO:0005856|GO:0005925|GO:0015629 cell|cell junction|binding|cell-substrate junction|intracellular organelle|intracellular|protein binding|cell-substrate adherens junction|adherens junction|cytoplasm|cytoskeletal protein binding|actin binding|cytoskeleton|focal adhesion|actin cytoskeleton - - - - 17:17042545-17217679 231 197 341 4677 5552 6082 0.646957874725361 0.501430452319537 0.861058255924003 11.7362425173296 12.7579640115207 15.9639123575274 0.6698155276563 13.4860396287926 -4.33155911095284 1.49138841471595e-65 8.90478194658602e-62 DOWN ENSG00000132953 XPO4 exportin 4 [Source:HGNC Symbol;Acc:HGNC:17796] GO:0005215|GO:0005623|GO:0009987|GO:0005488|GO:0050794|GO:0005487|GO:0043229|GO:0051050|GO:0051641|GO:0043227|GO:0005622|GO:1903829|GO:0005515|GO:0012505|GO:0060341|GO:0008565|GO:0006810|GO:0043231|GO:0019899|GO:0005737|GO:0032880|GO:0051222|GO:0005635|GO:0045184|GO:0032388|GO:0008104|GO:0005049|GO:0051649|GO:0090316|GO:0032386|GO:0051223|GO:0015031|GO:0070201|GO:0046907|GO:0031981|GO:0046827|GO:0005654|GO:0034613|GO:0051020|GO:1903827|GO:0005634|GO:0005643|GO:0033157|GO:0051169|GO:0006611|GO:0016482|GO:0006886|GO:0031267|GO:0046824|GO:0006913|GO:0017016|GO:0046825|GO:0046822|GO:0051168|GO:0008536 transporter activity|cell|cellular process|binding|regulation of cellular process|nucleocytoplasmic transporter activity|intracellular organelle|positive regulation of transport|cellular localization|membrane-bounded organelle|intracellular|positive regulation of cellular protein localization|protein binding|endomembrane system|regulation of cellular localization|protein transporter activity|transport|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of protein localization|positive regulation of protein transport|nuclear envelope|establishment of protein localization|positive regulation of intracellular transport|protein localization|nuclear export signal receptor activity|establishment of localization in cell|positive regulation of intracellular protein transport|regulation of intracellular transport|regulation of protein transport|protein transport|regulation of establishment of protein localization|intracellular transport|nuclear lumen|positive regulation of protein export from nucleus|nucleoplasm|cellular protein localization|GTPase binding|regulation of cellular protein localization|nucleus|nuclear pore|regulation of intracellular protein transport|nuclear transport|protein export from nucleus|cytosolic transport|intracellular protein transport|small GTPase binding|positive regulation of nucleocytoplasmic transport|nucleocytoplasmic transport|Ras GTPase binding|regulation of protein export from nucleus|regulation of nucleocytoplasmic transport|nuclear export|Ran GTPase binding - - - - 13:20777329-20903048 24 32 33 1028 1131 713 0.0947572991574492 0.114824384155516 0.117472780850339 3.6366006061965 3.66382826410042 2.6382931380524 0.109018154721101 3.31290733611644 -4.92545753981952 1.17234269052403e-62 5.83318644715073e-59 DOWN ENSG00000052841 TTC17 tetratricopeptide repeat domain 17 [Source:HGNC Symbol;Acc:HGNC:25596] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0016043|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0022607|GO:0005737|GO:0030030|GO:0030029|GO:0006996|GO:0007010|GO:0044782|GO:0006461|GO:0030036|GO:0005856|GO:0015629|GO:0034622|GO:0043623|GO:0007015|GO:0051258|GO:0008154|GO:0030041 cell|membrane|cellular process|binding|intracellular organelle|cellular component organization|cell periphery|intracellular|protein binding|plasma membrane|cellular component assembly|cytoplasm|cell projection organization|actin filament-based process|organelle organization|cytoskeleton organization|cilium organization|protein complex assembly|actin cytoskeleton organization|cytoskeleton|actin cytoskeleton|cellular macromolecular complex assembly|cellular protein complex assembly|actin filament organization|protein polymerization|actin polymerization or depolymerization|actin filament polymerization - - - - 11:43358932-43494933 49 52 97 1392 1435 1799 0.215406763832722 0.207752141452465 0.384457409284499 5.48276660188676 5.17585945364216 7.411783325188 0.269205438189895 6.02346979357231 -4.48381532556173 1.85913367623095e-60 7.92893953859983e-57 DOWN ENSG00000145715 RASA1 RAS p21 protein activator (GTPase activating protein) 1 [Source:HGNC Symbol;Acc:HGNC:9871] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0050794|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0031252|GO:0031224|GO:0030234|GO:0050793|GO:0016247|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0048514|GO:0007049|GO:0009898|GO:0008360|GO:0006935|GO:0045087|GO:0006725|GO:0048468|GO:0022402|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0032535|GO:0005102|GO:0034641|GO:0008047|GO:0006952|GO:0030155|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0019899|GO:0010243|GO:0005737|GO:0032970|GO:0001726|GO:0006928|GO:0098562|GO:0031589|GO:0015459|GO:0009966|GO:0060548|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0007162|GO:0050776|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0008219|GO:0050790|GO:0030030|GO:0001948|GO:0051301|GO:0048869|GO:0030029|GO:0009967|GO:0019538|GO:0043254|GO:0023014|GO:0010033|GO:0031323|GO:0016248|GO:0006996|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:1901215|GO:0005096|GO:0007166|GO:0032956|GO:1903047|GO:0001944|GO:0043412|GO:0007010|GO:0072358|GO:0051345|GO:0043069|GO:0030695|GO:0051252|GO:0070997|GO:1901652|GO:0000904|GO:0009790|GO:0071417|GO:0010812|GO:0008200|GO:0051347|GO:0036211|GO:0000278|GO:0007160|GO:0031235|GO:0043434|GO:0044344|GO:0001570|GO:0010810|GO:0051247|GO:0070848|GO:0022604|GO:0002764|GO:0006461|GO:1901214|GO:0030036|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:1902532|GO:0051246|GO:0051020|GO:0030154|GO:0030832|GO:0048858|GO:0019870|GO:1902531|GO:0016070|GO:0072359|GO:0032870|GO:0000910|GO:0043067|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:0034622|GO:1901653|GO:0043408|GO:0043523|GO:0043623|GO:0001953|GO:0071363|GO:0043087|GO:0016310|GO:0002768|GO:0038179|GO:0008064|GO:0061564|GO:0043547|GO:0051493|GO:0007167|GO:0001952|GO:0071375|GO:0043410|GO:0042981|GO:0043066|GO:0032868|GO:0051402|GO:0043524|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0051058|GO:0007015|GO:0048812|GO:0000281|GO:0030833|GO:0043549|GO:0006915|GO:0033674|GO:0048011|GO:0000186|GO:0051258|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0042327|GO:0046580|GO:0007169|GO:0008154|GO:0048010|GO:0048013|GO:0038095|GO:0071900|GO:0030041|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|intrinsic component of membrane|enzyme regulator activity|regulation of developmental process|channel regulator activity|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|blood vessel morphogenesis|cell cycle|cytoplasmic side of plasma membrane|regulation of cell shape|chemotaxis|innate immune response|cellular aromatic compound metabolic process|cell development|cell cycle process|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|regulation of cellular component size|receptor binding|cellular nitrogen compound metabolic process|enzyme activator activity|defense response|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|enzyme binding|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|ruffle|movement of cell or subcellular component|cytoplasmic side of membrane|cell-substrate adhesion|potassium channel regulator activity|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|negative regulation of cell adhesion|regulation of immune response|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|cell death|regulation of catalytic activity|cell projection organization|glycoprotein binding|cell division|cellular developmental process|actin filament-based process|positive regulation of signal transduction|protein metabolic process|regulation of protein complex assembly|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|channel inhibitor activity|organelle organization|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|negative regulation of neuron death|GTPase activator activity|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|mitotic cell cycle process|vasculature development|macromolecule modification|cytoskeleton organization|cardiovascular system development|positive regulation of hydrolase activity|negative regulation of programmed cell death|GTPase regulator activity|regulation of RNA metabolic process|neuron death|response to peptide|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|negative regulation of cell-substrate adhesion|ion channel inhibitor activity|positive regulation of transferase activity|protein modification process|mitotic cell cycle|cell-matrix adhesion|intrinsic component of the cytoplasmic side of the plasma membrane|response to peptide hormone|cellular response to fibroblast growth factor stimulus|vasculogenesis|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|response to growth factor|regulation of cell morphogenesis|immune response-regulating signaling pathway|protein complex assembly|regulation of neuron death|actin cytoskeleton organization|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|GTPase binding|cell differentiation|regulation of actin filament length|cell projection morphogenesis|potassium channel inhibitor activity|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|cellular response to hormone stimulus|cytokinesis|regulation of programmed cell death|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular macromolecular complex assembly|cellular response to peptide|regulation of MAPK cascade|regulation of neuron apoptotic process|cellular protein complex assembly|negative regulation of cell-matrix adhesion|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|regulation of actin polymerization or depolymerization|axon development|positive regulation of GTPase activity|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of apoptotic process|negative regulation of apoptotic process|response to insulin|neuron apoptotic process|negative regulation of neuron apoptotic process|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|actin filament organization|neuron projection morphogenesis|mitotic cytokinesis|regulation of actin filament polymerization|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|protein polymerization|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|negative regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|vascular endothelial growth factor receptor signaling pathway|ephrin receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|actin filament polymerization|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K04352 Ras GTPase-activating protein 1[-] hsa04010|hsa04014|hsa04360 MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Axon guidance - Homo sapiens (human) 5:87267888-87391931 90 96 141 1378 1479 1452 0.835360938082987 0.809812491745266 1.17995954760511 11.4598957426144 11.2634079748902 12.6307519554869 0.941710992477788 11.7846852243305 -3.64548504352628 3.44986949496426e-57 1.28740504878329e-53 DOWN ENSG00000152990 ADGRA3 adhesion G protein-coupled receptor A3 [Source:HGNC Symbol;Acc:HGNC:13839] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0009986|GO:0038023|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0009897|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0007166|GO:0004930 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|cell surface|signaling receptor activity|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|external side of plasma membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|G-protein coupled receptor activity - - - - 4:22345071-22516054 37 49 41 897 913 740 0.183460060318621 0.22081229682688 0.183288939389783 3.98505070104272 3.71434368239409 3.4387765692413 0.195853765511761 3.7127236508927 -4.24462916396558 1.3938160876902e-56 4.62344283132257e-53 DOWN ENSG00000060237 WNK1 WNK lysine deficient protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:14540] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0071704|GO:0043167|GO:0051051|GO:0044237|GO:0030234|GO:0016247|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0004857|GO:0048468|GO:0006810|GO:0007275|GO:0043168|GO:0001882|GO:0016772|GO:0043169|GO:0019899|GO:0005737|GO:0015459|GO:0007154|GO:0044092|GO:0007165|GO:0007586|GO:0008217|GO:0050790|GO:0051048|GO:0000166|GO:0019207|GO:0043086|GO:0048869|GO:0017081|GO:0019538|GO:0031324|GO:0031323|GO:0016248|GO:0050878|GO:0003013|GO:0032268|GO:0044058|GO:0019210|GO:0030157|GO:0046872|GO:0035639|GO:0043412|GO:0007589|GO:0019887|GO:0001883|GO:0008200|GO:0036211|GO:0032269|GO:0006811|GO:0032549|GO:0019902|GO:0019869|GO:0051046|GO:0045777|GO:0051346|GO:0016301|GO:0019900|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0007399|GO:0046903|GO:0017076|GO:0051246|GO:0030154|GO:0019870|GO:0016773|GO:0008015|GO:0003073|GO:0090188|GO:0048666|GO:0030182|GO:0010923|GO:0016311|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0003084|GO:1904030|GO:0004860|GO:0004672|GO:0033673|GO:0019901|GO:0022008|GO:0006464|GO:0043549|GO:0010921|GO:0006470|GO:0030291|GO:0035304|GO:0045859|GO:0006469|GO:0006468|GO:0048699|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:0004674|GO:0035305|GO:0001933|GO:0035303|GO:0035308|GO:0046777|GO:0071901|GO:0071900|GO:0018107 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|ion binding|negative regulation of transport|cellular metabolic process|enzyme regulator activity|channel regulator activity|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|enzyme inhibitor activity|cell development|transport|multicellular organism development|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|enzyme binding|cytoplasm|potassium channel regulator activity|cell communication|negative regulation of molecular function|signal transduction|digestion|regulation of blood pressure|regulation of catalytic activity|negative regulation of secretion|nucleotide binding|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|chloride channel regulator activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|channel inhibitor activity|regulation of body fluid levels|circulatory system process|regulation of cellular protein metabolic process|regulation of digestive system process|kinase inhibitor activity|pancreatic juice secretion|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|body fluid secretion|protein kinase regulator activity|purine nucleoside binding|ion channel inhibitor activity|protein modification process|negative regulation of cellular protein metabolic process|ion transport|ribonucleoside binding|phosphatase binding|chloride channel inhibitor activity|regulation of secretion|positive regulation of blood pressure|negative regulation of hydrolase activity|kinase activity|kinase binding|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|secretion|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|potassium channel inhibitor activity|phosphotransferase activity, alcohol group as acceptor|blood circulation|regulation of systemic arterial blood pressure|negative regulation of pancreatic juice secretion|neuron development|neuron differentiation|negative regulation of phosphatase activity|dephosphorylation|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|positive regulation of systemic arterial blood pressure|negative regulation of cyclin-dependent protein kinase activity|protein kinase inhibitor activity|protein kinase activity|negative regulation of kinase activity|protein kinase binding|neurogenesis|cellular protein modification process|regulation of kinase activity|regulation of phosphatase activity|protein dephosphorylation|protein serine/threonine kinase inhibitor activity|regulation of protein dephosphorylation|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|generation of neurons|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|protein serine/threonine kinase activity|negative regulation of dephosphorylation|negative regulation of protein phosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation|protein autophosphorylation|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation - - - - 12:752593-911452 226 265 321 2778 3099 3095 0.562469709968446 0.599400657082939 0.720296041034832 6.19470992710107 6.3282067469472 7.21905990281944 0.627388802695406 6.5806588589559 -3.39080034849936 4.60185066275553e-55 1.37383649685904e-51 DOWN ENSG00000086015 MAST2 microtubule associated serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:19035] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0016043|GO:0071944|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0048609|GO:0019222|GO:0043168|GO:0001882|GO:0016772|GO:0001817|GO:0043169|GO:0019899|GO:0005737|GO:0001816|GO:0032403|GO:0048515|GO:0007154|GO:0007276|GO:0007165|GO:0008092|GO:0000166|GO:0048869|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0042107|GO:0015631|GO:0042089|GO:0048232|GO:0046872|GO:0035639|GO:0043412|GO:0007010|GO:0001883|GO:0032655|GO:0008017|GO:0032615|GO:0036211|GO:0032549|GO:0019902|GO:0042035|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0051246|GO:0009059|GO:0030154|GO:0016773|GO:0005856|GO:0007283|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0015630|GO:0045075|GO:0004672|GO:0006464|GO:0006468|GO:0018193|GO:0004674|GO:0018105 developmental process|reproduction|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|cellular component organization|cell periphery|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|plasma membrane|transferase activity|multicellular organismal reproductive process|regulation of metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cytokine production|cation binding|enzyme binding|cytoplasm|cytokine production|protein complex binding|spermatid differentiation|cell communication|gamete generation|signal transduction|cytoskeletal protein binding|nucleotide binding|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|cytokine metabolic process|tubulin binding|cytokine biosynthetic process|male gamete generation|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|purine nucleoside binding|regulation of interleukin-12 production|microtubule binding|interleukin-12 production|protein modification process|ribonucleoside binding|phosphatase binding|regulation of cytokine biosynthetic process|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|spermatogenesis|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|regulation of interleukin-12 biosynthetic process|protein kinase activity|cellular protein modification process|protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|peptidyl-serine phosphorylation - - - - 1:45786987-46036124 123 89 177 2061 2345 2283 0.778930970348446 0.512229213043425 1.01060114913397 11.6941401186357 12.1843785140139 13.5496326069775 0.767253777508614 12.476050413209 -4.02331363355616 2.93307952523901e-54 7.96037783149868e-51 DOWN ENSG00000109911 ELP4 elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0008023|GO:0033588|GO:0006725|GO:1901360|GO:0016570|GO:0034641|GO:0046483|GO:0043231|GO:0019899|GO:0016746|GO:0005737|GO:0032403|GO:0006139|GO:0050790|GO:0019207|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0010468|GO:0034645|GO:0043412|GO:0019887|GO:0051252|GO:0006325|GO:0016573|GO:0036211|GO:0070063|GO:0031981|GO:1990234|GO:0005654|GO:0016747|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0000993|GO:0000123|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0043966|GO:0043967|GO:0016310|GO:0043175|GO:0008607|GO:0016407|GO:0016410|GO:0016568|GO:0006464|GO:0043549|GO:0006351|GO:0006355|GO:0006366|GO:0045859|GO:0006357|GO:0006468|GO:1903506|GO:0042325|GO:0006354|GO:0001932|GO:0018193|GO:0008080|GO:0006368|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|enzyme regulator activity|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|transcription elongation factor complex|Elongator holoenzyme complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|transferase activity, transferring acyl groups|cytoplasm|protein complex binding|nucleobase-containing compound metabolic process|regulation of catalytic activity|kinase regulator activity|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|protein kinase regulator activity|regulation of RNA metabolic process|chromatin organization|histone acetylation|protein modification process|RNA polymerase binding|nuclear lumen|transferase complex|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|RNA polymerase II core binding|histone acetyltransferase complex|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|histone H3 acetylation|histone H4 acetylation|phosphorylation|RNA polymerase core enzyme binding|phosphorylase kinase regulator activity|acetyltransferase activity|N-acyltransferase activity|chromatin modification|cellular protein modification process|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|DNA-templated transcription, elongation|regulation of protein phosphorylation|peptidyl-amino acid modification|N-acetyltransferase activity|transcription elongation from RNA polymerase II promoter|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity - - - - 11:31509750-31783998 13 10 14 406 455 391 0.232331846589337 0.162423704090625 0.22559189690601 6.50119466988536 6.67189913251376 6.54900712814711 0.206782482528657 6.57403364351541 -4.99059296085034 8.62641627526388e-53 2.14610859568107e-49 DOWN ENSG00000177570 SAMD12 sterile alpha motif domain containing 12 [Source:HGNC Symbol;Acc:HGNC:31750] GO:0005488|GO:0005515 binding|protein binding - - - - 8:118189459-118621995 6 7 4 530 689 1239 0.0317119762152724 0.0336278516932942 0.0190624081287345 2.50995275751368 2.98799236082983 6.13751281241511 0.0281340786791004 3.87848597691954 -7.10703105570631 1.00581694925202e-52 2.30981993868999e-49 DOWN ENSG00000198162 MAN1A2 mannosidase, alpha, class 1A, member 2 [Source:HGNC Symbol;Acc:HGNC:6822] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0048856|GO:0031090|GO:0006486|GO:0007585|GO:0048286|GO:0035295|GO:0007275|GO:0030324|GO:0048513|GO:0016798|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0030323|GO:0005783|GO:0070062|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0009311|GO:0034645|GO:0046872|GO:0043412|GO:0006487|GO:0060541|GO:0009100|GO:0036211|GO:0070085|GO:0004553|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0006491|GO:0018279|GO:0005509|GO:0006464|GO:0015923|GO:0018193|GO:0043687|GO:0004559|GO:0004571 developmental process|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|anatomical structure development|organelle membrane|protein glycosylation|respiratory gaseous exchange|lung alveolus development|tube development|multicellular organism development|lung development|animal organ development|hydrolase activity, acting on glycosyl bonds|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|respiratory tube development|endoplasmic reticulum|extracellular exosome|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|oligosaccharide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|protein N-linked glycosylation|respiratory system development|glycoprotein metabolic process|protein modification process|glycosylation|hydrolase activity, hydrolyzing O-glycosyl compounds|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|N-glycan processing|protein N-linked glycosylation via asparagine|calcium ion binding|cellular protein modification process|mannosidase activity|peptidyl-amino acid modification|post-translational protein modification|alpha-mannosidase activity|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase[3.2.1.113] hsa01100|hsa04141|hsa00510 Metabolic pathways - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 1:117367449-117528872 224 268 381 3080 3564 3251 1.42902660270805 1.55384171691835 2.19145055026942 17.6051967760832 18.6551236108696 19.4374131182464 1.72477295663194 18.5659111683997 -3.42817775285642 1.5303859735475e-52 3.26343877530622e-49 DOWN ENSG00000105810 CDK6 cyclin-dependent kinase 6 [Source:HGNC Symbol;Acc:HGNC:1777] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0002683|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0051707|GO:0007155|GO:0043227|GO:0002262|GO:0009607|GO:0009605|GO:0009893|GO:0031252|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:1903706|GO:0016337|GO:0045595|GO:0009888|GO:0048468|GO:0022402|GO:0021766|GO:0007275|GO:0045596|GO:0048513|GO:0030279|GO:0070489|GO:0034101|GO:0043168|GO:0030155|GO:0030900|GO:0001882|GO:0016772|GO:0033554|GO:0007420|GO:0098609|GO:0045786|GO:0043231|GO:0045646|GO:0048144|GO:0005737|GO:0030332|GO:0060322|GO:0001726|GO:0006928|GO:0042592|GO:0031018|GO:0009615|GO:0001775|GO:0031589|GO:0050673|GO:0000307|GO:0046649|GO:0007154|GO:0051270|GO:0007165|GO:0021670|GO:0030278|GO:0001503|GO:0045785|GO:0090344|GO:0008285|GO:0031016|GO:0021543|GO:0021542|GO:0000166|GO:0051301|GO:0048869|GO:2000145|GO:2000773|GO:0021537|GO:0019538|GO:0007568|GO:0005829|GO:0005813|GO:0010468|GO:2000772|GO:0030218|GO:0045668|GO:0007166|GO:0035639|GO:1903047|GO:0043412|GO:0030097|GO:0030098|GO:0007417|GO:0021782|GO:0002064|GO:0005815|GO:0001883|GO:0044770|GO:0045667|GO:0021761|GO:0007050|GO:0010628|GO:0036211|GO:0000278|GO:0007160|GO:0048872|GO:0032549|GO:0001649|GO:0048145|GO:0007569|GO:0003309|GO:0035270|GO:0031981|GO:1990234|GO:0007159|GO:0010810|GO:0048146|GO:0005654|GO:0050678|GO:0016301|GO:0050680|GO:0042110|GO:0060429|GO:0006796|GO:0044267|GO:0021591|GO:0010467|GO:0007399|GO:0017076|GO:0043697|GO:0010811|GO:0030154|GO:0016773|GO:0005856|GO:0005634|GO:0090398|GO:0045638|GO:0045637|GO:0003323|GO:0002521|GO:0048863|GO:0010001|GO:0030855|GO:0002066|GO:0005524|GO:0044772|GO:0030217|GO:0014002|GO:0030554|GO:0016310|GO:0070486|GO:0001952|GO:0015630|GO:0001954|GO:0033077|GO:0004672|GO:0002244|GO:0030099|GO:0007219|GO:0022008|GO:0006464|GO:0048708|GO:0060218|GO:1902911|GO:0006468|GO:0048699|GO:0002068|GO:0000082|GO:0042063|GO:0004674|GO:0097472|GO:0071593|GO:0002067|GO:0004693|GO:1902554|GO:0035883 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|negative regulation of immune system process|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|response to other organism|cell adhesion|membrane-bounded organelle|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|cell leading edge|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of cell differentiation|tissue development|cell development|cell cycle process|hippocampus development|multicellular organism development|negative regulation of cell differentiation|animal organ development|negative regulation of ossification|T cell aggregation|erythrocyte homeostasis|anion binding|regulation of cell adhesion|forebrain development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular response to stress|brain development|cell-cell adhesion|negative regulation of cell cycle|intracellular membrane-bounded organelle|regulation of erythrocyte differentiation|fibroblast proliferation|cytoplasm|cyclin binding|head development|ruffle|movement of cell or subcellular component|homeostatic process|endocrine pancreas development|response to virus|cell activation|cell-substrate adhesion|epithelial cell proliferation|cyclin-dependent protein kinase holoenzyme complex|lymphocyte activation|cell communication|regulation of cellular component movement|signal transduction|lateral ventricle development|regulation of ossification|ossification|positive regulation of cell adhesion|negative regulation of cell aging|negative regulation of cell proliferation|pancreas development|pallium development|dentate gyrus development|nucleotide binding|cell division|cellular developmental process|regulation of cell motility|negative regulation of cellular senescence|telencephalon development|protein metabolic process|aging|cytosol|centrosome|regulation of gene expression|regulation of cellular senescence|erythrocyte differentiation|negative regulation of osteoblast differentiation|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|hemopoiesis|lymphocyte differentiation|central nervous system development|glial cell development|epithelial cell development|microtubule organizing center|purine nucleoside binding|cell cycle phase transition|regulation of osteoblast differentiation|limbic system development|cell cycle arrest|positive regulation of gene expression|protein modification process|mitotic cell cycle|cell-matrix adhesion|homeostasis of number of cells|ribonucleoside binding|osteoblast differentiation|regulation of fibroblast proliferation|cell aging|type B pancreatic cell differentiation|endocrine system development|nuclear lumen|transferase complex|leukocyte cell-cell adhesion|regulation of cell-substrate adhesion|positive regulation of fibroblast proliferation|nucleoplasm|regulation of epithelial cell proliferation|kinase activity|negative regulation of epithelial cell proliferation|T cell activation|epithelium development|phosphate-containing compound metabolic process|cellular protein metabolic process|ventricular system development|gene expression|nervous system development|purine nucleotide binding|cell dedifferentiation|positive regulation of cell-substrate adhesion|cell differentiation|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|cellular senescence|negative regulation of myeloid cell differentiation|regulation of myeloid cell differentiation|type B pancreatic cell development|leukocyte differentiation|stem cell differentiation|glial cell differentiation|epithelial cell differentiation|columnar/cuboidal epithelial cell development|ATP binding|mitotic cell cycle phase transition|T cell differentiation|astrocyte development|adenyl nucleotide binding|phosphorylation|leukocyte aggregation|regulation of cell-matrix adhesion|microtubule cytoskeleton|positive regulation of cell-matrix adhesion|T cell differentiation in thymus|protein kinase activity|hematopoietic progenitor cell differentiation|myeloid cell differentiation|Notch signaling pathway|neurogenesis|cellular protein modification process|astrocyte differentiation|hematopoietic stem cell differentiation|protein kinase complex|protein phosphorylation|generation of neurons|glandular epithelial cell development|G1/S transition of mitotic cell cycle|gliogenesis|protein serine/threonine kinase activity|cyclin-dependent protein kinase activity|lymphocyte aggregation|glandular epithelial cell differentiation|cyclin-dependent protein serine/threonine kinase activity|serine/threonine protein kinase complex|enteroendocrine cell differentiation K02091 cyclin-dependent kinase 6[2.7.11.22] hsa05200|hsa04151|hsa05206|hsa05203|hsa05161|hsa05162|hsa04110|hsa05222|hsa05220|hsa05218|hsa04115|hsa05212|hsa05214|hsa05223 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Measles - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Melanoma - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Glioma - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human) 7:92604921-92836594 20 40 69 1450 1153 1589 0.104032467086712 0.189094204218162 0.323596254521849 6.75778797012517 4.92080411018005 7.74625388295239 0.205574308608908 6.4749486544192 -4.9771368705341 5.76490981510676e-52 1.14737078413465e-48 DOWN ENSG00000181090 EHMT1 euchromatic histone-lysine N-methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:24650] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0032259|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0016570|GO:0002039|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0009890|GO:0019904|GO:0006139|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0009636|GO:0051276|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0060992|GO:0010629|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0009790|GO:0036211|GO:0006306|GO:0070742|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0061647|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006304|GO:0051567|GO:0018022|GO:0008276|GO:0034968|GO:0046914|GO:0016568|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0070734|GO:0006366|GO:1903507|GO:0006357|GO:0016279|GO:1903506|GO:0018193|GO:0042054|GO:0018027|GO:0000122|GO:0018026|GO:0008270|GO:0018024|GO:0018205|GO:0046974|GO:0046976 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|methylation|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|histone modification|p53 binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|negative regulation of biosynthetic process|protein domain specific binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|response to toxic substance|chromosome organization|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|response to fungicide|negative regulation of gene expression|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|embryo development|protein modification process|DNA methylation|C2H2 zinc finger domain binding|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|histone H3-K9 modification|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|DNA modification|histone H3-K9 methylation|peptidyl-lysine methylation|protein methyltransferase activity|histone lysine methylation|transition metal ion binding|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|histone H3-K27 methylation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|protein-lysine N-methyltransferase activity|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone methyltransferase activity|peptidyl-lysine dimethylation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|zinc ion binding|histone-lysine N-methyltransferase activity|peptidyl-lysine modification|histone methyltransferase activity (H3-K9 specific)|histone methyltransferase activity (H3-K27 specific) K11420 euchromatic histone-lysine N-methyltransferase[2.1.1.43] hsa04211 Longevity regulating pathway - mammal - Homo sapiens (human) 9:137618963-137870016 113 115 164 1396 1582 1311 0.352187920706802 0.325743309999597 0.460844797939992 3.89833700577966 4.04548763123339 3.82937708347289 0.379592009548797 3.92440057349531 -3.36995077969517 2.31588221767439e-51 4.3211467329032e-48 DOWN ENSG00000178234 GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 [Source:HGNC Symbol;Acc:HGNC:19875] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0030246|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0007507|GO:0006486|GO:0007275|GO:0048513|GO:0005102|GO:0043231|GO:0043169|GO:0005737|GO:0007389|GO:0005975|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0016757|GO:0030030|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0005112|GO:0000902|GO:0034645|GO:0046872|GO:0007166|GO:0043412|GO:0072358|GO:0061314|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0008593|GO:0070085|GO:1901137|GO:0044267|GO:0032990|GO:0000139|GO:0009059|GO:0048858|GO:0072359|GO:0060271|GO:0009101|GO:0043413|GO:0007220|GO:0009855|GO:0018243|GO:0008376|GO:0007219|GO:0006464|GO:0016266|GO:0004653|GO:0007368|GO:0018193|GO:0043687 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|heart development|protein glycosylation|multicellular organism development|animal organ development|receptor binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|pattern specification process|carbohydrate metabolic process|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|transferase activity, transferring glycosyl groups|cell projection organization|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|Notch binding|cell morphogenesis|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|cardiovascular system development|Notch signaling involved in heart development|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|regulation of Notch signaling pathway|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|cell part morphogenesis|Golgi membrane|macromolecule biosynthetic process|cell projection morphogenesis|circulatory system development|cilium morphogenesis|glycoprotein biosynthetic process|macromolecule glycosylation|Notch receptor processing|determination of bilateral symmetry|protein O-linked glycosylation via threonine|acetylgalactosaminyltransferase activity|Notch signaling pathway|cellular protein modification process|O-glycan processing|polypeptide N-acetylgalactosaminyltransferase activity|determination of left/right symmetry|peptidyl-amino acid modification|post-translational protein modification K00710 polypeptide N-acetylgalactosaminyltransferase[2.4.1.41] hsa01100|hsa00512 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human) 7:152025674-152122347 56 46 68 782 930 933 0.282928241407324 0.211214620072652 0.309747449401403 3.53990141168713 3.85511713395654 4.41770996928471 0.26796343696046 3.93757617164279 -3.8771997658612 5.05299868440491e-51 8.87366016024848e-48 DOWN ENSG00000157985 AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 [Source:HGNC Symbol;Acc:HGNC:16922] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0008289|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0006810|GO:0043168|GO:0008047|GO:0005543|GO:0001882|GO:0043169|GO:0005737|GO:0045184|GO:0043085|GO:0008104|GO:0007154|GO:0007165|GO:0050790|GO:0000166|GO:0005096|GO:0046872|GO:0035639|GO:0051345|GO:0030695|GO:0001883|GO:0015031|GO:0032549|GO:0035556|GO:0017076|GO:0032561|GO:0043087|GO:0043547|GO:0005525|GO:0007264|GO:0019001 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|lipid binding|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|transport|anion binding|enzyme activator activity|phospholipid binding|nucleoside binding|cation binding|cytoplasm|establishment of protein localization|positive regulation of catalytic activity|protein localization|cell communication|signal transduction|regulation of catalytic activity|nucleotide binding|GTPase activator activity|metal ion binding|purine ribonucleoside triphosphate binding|positive regulation of hydrolase activity|GTPase regulator activity|purine nucleoside binding|protein transport|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|regulation of GTPase activity|positive regulation of GTPase activity|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding K12491 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3[-] hsa04144 Endocytosis - Homo sapiens (human) 2:235494089-236131800 79 130 148 1415 1664 1391 0.272940479936807 0.408193282713638 0.461018105992901 4.38023155336519 4.71698435543505 4.50400686565751 0.380717289547782 4.53374092481925 -3.57390995862106 6.26846690359481e-51 1.03966006077733e-47 DOWN ENSG00000198554 WDHD1 WD repeat and HMG-box DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23170] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0005737|GO:0003677|GO:0031981|GO:0005654|GO:0005634 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|cytoplasm|DNA binding|nuclear lumen|nucleoplasm|nucleus - - - - 14:54938950-55027105 60 40 93 1388 1485 1080 0.509631671438112 0.308776667046443 0.712198843036745 10.5631212752801 10.3490268130939 8.59720949030218 0.510202393840433 9.83645252622539 -4.26899653456792 8.55883160160917e-51 1.34481767702337e-47 DOWN ENSG00000171004 HS6ST2 heparan sulfate 6-O-sulfotransferase 2 [Source:HGNC Symbol;Acc:HGNC:19133] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006082|GO:0044281|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0070062|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0034645|GO:0015012|GO:0009100|GO:0031981|GO:0030201|GO:0005654|GO:1901137|GO:0008146|GO:0000139|GO:0009059|GO:0005634|GO:0009101|GO:0006024|GO:0006029|GO:0030203|GO:0015015|GO:0030166|GO:0017095 cell|membrane|cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|organic acid metabolic process|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|extracellular exosome|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|cellular macromolecule biosynthetic process|heparan sulfate proteoglycan biosynthetic process|glycoprotein metabolic process|nuclear lumen|heparan sulfate proteoglycan metabolic process|nucleoplasm|carbohydrate derivative biosynthetic process|sulfotransferase activity|Golgi membrane|macromolecule biosynthetic process|nucleus|glycoprotein biosynthetic process|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|glycosaminoglycan metabolic process|heparan sulfate proteoglycan biosynthetic process, enzymatic modification|proteoglycan biosynthetic process|heparan sulfate 6-O-sulfotransferase activity K08102 heparan sulfate 6-O-sulfotransferase HS6ST2 [EC:2.8.2.-][-] hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human) X:132626016-132961395 68 84 109 962 1181 1145 0.652568316825657 0.732618827111903 0.943106877866969 8.27164949463974 9.29902157244786 10.2980190230351 0.776098007268176 9.28956336337423 -3.58130003176306 1.57476096197194e-50 2.35064568793552e-47 DOWN ENSG00000081026 MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 [Source:HGNC Symbol;Acc:HGNC:29647] GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0032947|GO:0044237|GO:0005911|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0016032|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0043231|GO:0006139|GO:0055086|GO:0007154|GO:0007165|GO:0008219|GO:0000166|GO:0043296|GO:0035639|GO:0019693|GO:0001883|GO:0009116|GO:0032549|GO:0016301|GO:0012501|GO:0006796|GO:0035556|GO:0017076|GO:0005923|GO:0005634|GO:0016776|GO:0009259|GO:0009117|GO:0005524|GO:0030554|GO:0019205|GO:0004385|GO:0009132|GO:0006163|GO:0042278|GO:0006915|GO:0019201|GO:0046037|GO:0046710 structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|protein complex scaffold|cellular metabolic process|cell-cell junction|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|transferase activity|viral process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|cell death|nucleotide binding|apical junction complex|purine ribonucleoside triphosphate binding|ribose phosphate metabolic process|purine nucleoside binding|nucleoside metabolic process|ribonucleoside binding|kinase activity|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|purine nucleotide binding|bicellular tight junction|nucleus|phosphotransferase activity, phosphate group as acceptor|ribonucleotide metabolic process|nucleotide metabolic process|ATP binding|adenyl nucleotide binding|nucleobase-containing compound kinase activity|guanylate kinase activity|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|purine nucleoside metabolic process|apoptotic process|nucleotide kinase activity|GMP metabolic process|GDP metabolic process K06112 membrane-associated guanylate kinase-related[-] hsa04015|hsa04530 Rap1 signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human) 1:113390749-113685923 108 150 190 1598 1765 1607 0.777246525907652 0.981086103556865 1.2328310242758 10.3041208872198 10.4219520134138 10.8388026253504 0.997054551246772 10.521625175328 -3.39954131090236 1.73171794538071e-50 2.46184321625694e-47 DOWN ENSG00000107263 RAPGEF1 Rap guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:4568] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0016043|GO:0007155|GO:0043227|GO:0023057|GO:0009893|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0005085|GO:0048856|GO:0019222|GO:0042127|GO:0016337|GO:0045595|GO:0009888|GO:0048468|GO:0051130|GO:0001568|GO:0007275|GO:0031325|GO:0051128|GO:0022607|GO:0098609|GO:0045597|GO:0043231|GO:0010243|GO:0005737|GO:0005088|GO:1990089|GO:1901888|GO:0009966|GO:0019904|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0009968|GO:0061351|GO:0008285|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0005768|GO:0000165|GO:1902533|GO:0032268|GO:0030111|GO:0005829|GO:0031175|GO:0031344|GO:0030178|GO:0007166|GO:0014074|GO:0001944|GO:0043412|GO:1990090|GO:0072358|GO:0051345|GO:0010720|GO:0005769|GO:0002064|GO:2000178|GO:0017124|GO:0046683|GO:0017034|GO:0031346|GO:0071417|GO:0051347|GO:0036211|GO:0032269|GO:0034329|GO:0050769|GO:0051247|GO:0070848|GO:0051591|GO:0032270|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0007399|GO:0071310|GO:1902532|GO:0051246|GO:0030154|GO:1902531|GO:2000177|GO:0072359|GO:0051960|GO:0048666|GO:0030182|GO:0051896|GO:0003158|GO:0016055|GO:0043491|GO:0010975|GO:0001885|GO:0038180|GO:0051898|GO:0031401|GO:0090090|GO:0030855|GO:0043408|GO:0060828|GO:0071363|GO:0043087|GO:0016310|GO:0038179|GO:0070371|GO:0071407|GO:0043547|GO:0007167|GO:0043410|GO:0043409|GO:0071320|GO:0051056|GO:0022008|GO:0007264|GO:0006464|GO:0051058|GO:0050767|GO:0010976|GO:0043549|GO:0033674|GO:0045666|GO:0048011|GO:0061028|GO:0000186|GO:0045446|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0006468|GO:0048699|GO:0060070|GO:0043405|GO:0042325|GO:0001932|GO:0042326|GO:0001934|GO:0001933|GO:0070372|GO:0070373|GO:0045664|GO:0042327|GO:0046580|GO:0007169|GO:0032486|GO:0048008|GO:0071900|GO:0032147 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|cellular component organization|cell adhesion|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|regulation of developmental process|intracellular|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|single organismal cell-cell adhesion|regulation of cell differentiation|tissue development|cell development|positive regulation of cellular component organization|blood vessel development|multicellular organism development|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|Ras guanyl-nucleotide exchange factor activity|response to nerve growth factor|regulation of cell junction assembly|regulation of signal transduction|protein domain specific binding|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|negative regulation of signal transduction|neural precursor cell proliferation|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endosome|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cytosol|neuron projection development|regulation of cell projection organization|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|response to purine-containing compound|vasculature development|macromolecule modification|cellular response to nerve growth factor stimulus|cardiovascular system development|positive regulation of hydrolase activity|positive regulation of cell development|early endosome|epithelial cell development|negative regulation of neural precursor cell proliferation|SH3 domain binding|response to organophosphorus|Rap guanyl-nucleotide exchange factor activity|positive regulation of cell projection organization|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|cell junction assembly|positive regulation of neurogenesis|positive regulation of protein metabolic process|response to growth factor|response to cAMP|positive regulation of cellular protein metabolic process|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|regulation of intracellular signal transduction|regulation of neural precursor cell proliferation|circulatory system development|regulation of nervous system development|neuron development|neuron differentiation|regulation of protein kinase B signaling|endothelium development|Wnt signaling pathway|protein kinase B signaling|regulation of neuron projection development|endothelial cell development|nerve growth factor signaling pathway|negative regulation of protein kinase B signaling|positive regulation of protein modification process|negative regulation of canonical Wnt signaling pathway|epithelial cell differentiation|regulation of MAPK cascade|regulation of canonical Wnt signaling pathway|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|neurotrophin signaling pathway|ERK1 and ERK2 cascade|cellular response to organic cyclic compound|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|negative regulation of MAPK cascade|cellular response to cAMP|regulation of small GTPase mediated signal transduction|neurogenesis|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|regulation of neurogenesis|positive regulation of neuron projection development|regulation of kinase activity|positive regulation of kinase activity|positive regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|establishment of endothelial barrier|activation of MAPKK activity|endothelial cell differentiation|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|generation of neurons|canonical Wnt signaling pathway|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|regulation of neuron differentiation|positive regulation of phosphorylation|negative regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|Rap protein signal transduction|platelet-derived growth factor receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity K06277 Rap guanine nucleotide exchange factor 1[-] hsa04015|hsa04510|hsa04910|hsa04722|hsa05211 Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human) 9:131576770-131740074 49 44 97 1083 1145 1232 0.32505957393157 0.265276309807658 0.580165448072481 6.43713055035753 6.2321751512436 7.65959516403985 0.390167110603903 6.77630028854699 -4.11833373318913 2.07194814181223e-49 2.8116336284392e-46 DOWN ENSG00000140992 PDPK1 3-phosphoinositide dependent protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:8816] GO:0040011|GO:0032502|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0002683|GO:0097159|GO:0009892|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0045321|GO:0060076|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0060341|GO:0002757|GO:0051282|GO:0050817|GO:0016337|GO:0045087|GO:0006725|GO:0051640|GO:0009888|GO:0048468|GO:0050867|GO:0006810|GO:0070849|GO:0051130|GO:1901360|GO:0010941|GO:0007275|GO:0010632|GO:0010524|GO:0060627|GO:0048513|GO:0070489|GO:0005102|GO:0034641|GO:0043168|GO:0008047|GO:0005924|GO:0032940|GO:0006952|GO:0030155|GO:0005912|GO:0001882|GO:0043270|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0090287|GO:0022607|GO:0098609|GO:0034122|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0002218|GO:0007267|GO:0009611|GO:0032880|GO:0071559|GO:0006928|GO:0032403|GO:0042592|GO:0031018|GO:0051656|GO:0002696|GO:0001775|GO:0031589|GO:0009966|GO:0002263|GO:0045184|GO:0019725|GO:0097481|GO:0014069|GO:0060548|GO:0032388|GO:0010646|GO:0090288|GO:0006139|GO:0043085|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0055085|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0002366|GO:0050778|GO:0090004|GO:0009968|GO:0051649|GO:0045785|GO:2000021|GO:0009725|GO:0008219|GO:0006970|GO:0031016|GO:0050790|GO:0031295|GO:0000166|GO:0051238|GO:0043086|GO:0043299|GO:0048869|GO:0030029|GO:2000145|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0010256|GO:0050878|GO:0002443|GO:0006996|GO:0071774|GO:0016192|GO:0051249|GO:0032268|GO:0005829|GO:0010468|GO:0090132|GO:0034645|GO:0045216|GO:0030168|GO:0090150|GO:0090101|GO:0007166|GO:0035639|GO:0043412|GO:0007010|GO:0002758|GO:0031410|GO:0051345|GO:0060229|GO:0043069|GO:0002064|GO:0048878|GO:0007596|GO:0051252|GO:0043274|GO:0043303|GO:0032386|GO:0001883|GO:0033003|GO:0034109|GO:1901652|GO:0071417|GO:0051208|GO:0030334|GO:0034767|GO:0001667|GO:0007009|GO:0016023|GO:0006887|GO:0051347|GO:0036211|GO:0032269|GO:0071560|GO:0070201|GO:0007160|GO:0042060|GO:0046907|GO:0006811|GO:0051209|GO:0032549|GO:0055082|GO:0005158|GO:0045576|GO:0071364|GO:0051251|GO:0034329|GO:0002429|GO:0017157|GO:0022407|GO:0051279|GO:0051046|GO:0003309|GO:0072657|GO:0035270|GO:0031981|GO:0043434|GO:0007599|GO:0044344|GO:0007159|GO:0051247|GO:0070848|GO:0031988|GO:0034765|GO:0005654|GO:0002764|GO:0016301|GO:0006972|GO:0030036|GO:0043269|GO:0034613|GO:0019900|GO:0032270|GO:0042110|GO:0012501|GO:0060429|GO:0006796|GO:1903078|GO:0035556|GO:0044267|GO:0051174|GO:0051281|GO:0010467|GO:0046903|GO:0071310|GO:0017076|GO:0010594|GO:0051246|GO:0009059|GO:0010522|GO:0030154|GO:0022409|GO:0032418|GO:0034121|GO:1903827|GO:1902531|GO:0016070|GO:0051928|GO:0016773|GO:0032870|GO:0005634|GO:0043067|GO:0045089|GO:0005925|GO:0097190|GO:0045088|GO:0034220|GO:0003323|GO:0090003|GO:0098655|GO:0045055|GO:0031401|GO:0050863|GO:0043304|GO:0043122|GO:0008543|GO:0030855|GO:1901653|GO:0034332|GO:0072659|GO:0090002|GO:0032774|GO:0002066|GO:0005524|GO:0090280|GO:0006812|GO:2001141|GO:0071363|GO:0030554|GO:0016310|GO:0002768|GO:0038179|GO:0034112|GO:0060402|GO:0002221|GO:0007179|GO:0070486|GO:0030512|GO:0016482|GO:0048017|GO:0007167|GO:0007044|GO:0007249|GO:0071375|GO:0002448|GO:1903305|GO:0010631|GO:0042981|GO:0048041|GO:0050801|GO:0043066|GO:0004672|GO:0033673|GO:0032868|GO:1903076|GO:1904427|GO:0019901|GO:0007264|GO:0006464|GO:0050870|GO:0050851|GO:0019932|GO:0016004|GO:0097191|GO:1990778|GO:0060193|GO:0043549|GO:0017015|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0090279|GO:0034333|GO:1903039|GO:0033674|GO:0048011|GO:1903169|GO:0002223|GO:0045859|GO:0048015|GO:0045860|GO:0002224|GO:0006469|GO:0010517|GO:0006468|GO:1903506|GO:0002068|GO:0042325|GO:0001932|GO:0032869|GO:0018193|GO:0042326|GO:0038093|GO:0004674|GO:0030001|GO:0001934|GO:0019722|GO:0010657|GO:0007178|GO:0051924|GO:0050852|GO:0010518|GO:0001933|GO:0010656|GO:0043542|GO:0071593|GO:0030003|GO:0042327|GO:0007268|GO:0007169|GO:0048010|GO:0002067|GO:0070588|GO:0010664|GO:0055065|GO:0046777|GO:0038095|GO:0097553|GO:0006875|GO:0018105|GO:0018107|GO:0032147|GO:0008286|GO:0004676|GO:0038127|GO:0032148|GO:0035883|GO:0007173|GO:0006874|GO:0006816|GO:0010659|GO:0055074|GO:0010667|GO:0051480|GO:0070509|GO:0060401|GO:0007204 locomotion|developmental process|immune system process|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|leukocyte activation|excitatory synapse|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cellular localization|immune response-activating signal transduction|regulation of sequestering of calcium ion|coagulation|single organismal cell-cell adhesion|innate immune response|cellular aromatic compound metabolic process|organelle localization|tissue development|cell development|positive regulation of cell activation|transport|response to epidermal growth factor|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|positive regulation of calcium ion transport into cytosol|regulation of vesicle-mediated transport|animal organ development|T cell aggregation|receptor binding|cellular nitrogen compound metabolic process|anion binding|enzyme activator activity|cell-substrate adherens junction|secretion by cell|defense response|regulation of cell adhesion|adherens junction|nucleoside binding|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|regulation of cellular response to growth factor stimulus|cellular component assembly|cell-cell adhesion|negative regulation of toll-like receptor signaling pathway|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|activation of innate immune response|cell-cell signaling|response to wounding|regulation of protein localization|response to transforming growth factor beta|movement of cell or subcellular component|protein complex binding|homeostatic process|endocrine pancreas development|establishment of organelle localization|positive regulation of leukocyte activation|cell activation|cell-substrate adhesion|regulation of signal transduction|cell activation involved in immune response|establishment of protein localization|cellular homeostasis|neuronal postsynaptic density|postsynaptic density|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|transmembrane transport|membrane organization|regulation of cellular component movement|cell migration|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|positive regulation of establishment of protein localization to plasma membrane|negative regulation of signal transduction|establishment of localization in cell|positive regulation of cell adhesion|regulation of ion homeostasis|response to hormone|cell death|response to osmotic stress|pancreas development|regulation of catalytic activity|T cell costimulation|nucleotide binding|sequestering of metal ion|negative regulation of catalytic activity|leukocyte degranulation|cellular developmental process|actin filament-based process|regulation of cell motility|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endomembrane system organization|regulation of body fluid levels|leukocyte mediated immunity|organelle organization|response to fibroblast growth factor|vesicle-mediated transport|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|cell-cell junction organization|platelet activation|establishment of protein localization to membrane|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|innate immune response-activating signal transduction|cytoplasmic vesicle|positive regulation of hydrolase activity|lipase activator activity|negative regulation of programmed cell death|epithelial cell development|chemical homeostasis|blood coagulation|regulation of RNA metabolic process|phospholipase binding|mast cell degranulation|regulation of intracellular transport|purine nucleoside binding|regulation of mast cell activation|homotypic cell-cell adhesion|response to peptide|cellular response to organonitrogen compound|sequestering of calcium ion|regulation of cell migration|positive regulation of ion transmembrane transport|ameboidal-type cell migration|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|exocytosis|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|regulation of establishment of protein localization|cell-matrix adhesion|wound healing|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|ribonucleoside binding|cellular chemical homeostasis|insulin receptor binding|mast cell activation|cellular response to epidermal growth factor stimulus|positive regulation of lymphocyte activation|cell junction assembly|immune response-activating cell surface receptor signaling pathway|regulation of exocytosis|regulation of cell-cell adhesion|regulation of release of sequestered calcium ion into cytosol|regulation of secretion|type B pancreatic cell differentiation|protein localization to membrane|endocrine system development|nuclear lumen|response to peptide hormone|hemostasis|cellular response to fibroblast growth factor stimulus|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|response to growth factor|membrane-bounded vesicle|regulation of ion transmembrane transport|nucleoplasm|immune response-regulating signaling pathway|kinase activity|hyperosmotic response|actin cytoskeleton organization|regulation of ion transport|cellular protein localization|kinase binding|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|epithelium development|phosphate-containing compound metabolic process|positive regulation of protein localization to plasma membrane|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of release of sequestered calcium ion into cytosol|gene expression|secretion|cellular response to organic substance|purine nucleotide binding|regulation of endothelial cell migration|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|cell differentiation|positive regulation of cell-cell adhesion|lysosome localization|regulation of toll-like receptor signaling pathway|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of calcium ion transport|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|nucleus|regulation of programmed cell death|positive regulation of innate immune response|focal adhesion|apoptotic signaling pathway|regulation of innate immune response|ion transmembrane transport|type B pancreatic cell development|regulation of establishment of protein localization to plasma membrane|cation transmembrane transport|regulated exocytosis|positive regulation of protein modification process|regulation of T cell activation|regulation of mast cell degranulation|regulation of I-kappaB kinase/NF-kappaB signaling|fibroblast growth factor receptor signaling pathway|epithelial cell differentiation|cellular response to peptide|adherens junction organization|protein localization to plasma membrane|establishment of protein localization to plasma membrane|RNA biosynthetic process|columnar/cuboidal epithelial cell development|ATP binding|positive regulation of calcium ion import|cation transport|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|positive regulation of homotypic cell-cell adhesion|calcium ion transport into cytosol|pattern recognition receptor signaling pathway|transforming growth factor beta receptor signaling pathway|leukocyte aggregation|negative regulation of transforming growth factor beta receptor signaling pathway|cytosolic transport|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|cell-substrate junction assembly|I-kappaB kinase/NF-kappaB signaling|cellular response to peptide hormone stimulus|mast cell mediated immunity|regulation of regulated secretory pathway|epithelial cell migration|regulation of apoptotic process|focal adhesion assembly|ion homeostasis|negative regulation of apoptotic process|protein kinase activity|negative regulation of kinase activity|response to insulin|regulation of protein localization to plasma membrane|positive regulation of calcium ion transmembrane transport|protein kinase binding|small GTPase mediated signal transduction|cellular protein modification process|positive regulation of T cell activation|antigen receptor-mediated signaling pathway|second-messenger-mediated signaling|phospholipase activator activity|extrinsic apoptotic signaling pathway|protein localization to cell periphery|positive regulation of lipase activity|regulation of kinase activity|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of calcium ion import|adherens junction assembly|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|regulation of calcium ion transmembrane transport|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|toll-like receptor signaling pathway|negative regulation of protein kinase activity|regulation of phospholipase activity|protein phosphorylation|regulation of nucleic acid-templated transcription|glandular epithelial cell development|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|negative regulation of phosphorylation|Fc receptor signaling pathway|protein serine/threonine kinase activity|metal ion transport|positive regulation of protein phosphorylation|calcium-mediated signaling|muscle cell apoptotic process|transmembrane receptor protein serine/threonine kinase signaling pathway|regulation of calcium ion transport|T cell receptor signaling pathway|positive regulation of phospholipase activity|negative regulation of protein phosphorylation|negative regulation of muscle cell apoptotic process|endothelial cell migration|lymphocyte aggregation|cellular cation homeostasis|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|glandular epithelial cell differentiation|calcium ion transmembrane transport|negative regulation of striated muscle cell apoptotic process|metal ion homeostasis|protein autophosphorylation|Fc-epsilon receptor signaling pathway|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|activation of protein kinase activity|insulin receptor signaling pathway|3-phosphoinositide-dependent protein kinase activity|ERBB signaling pathway|activation of protein kinase B activity|enteroendocrine cell differentiation|epidermal growth factor receptor signaling pathway|cellular calcium ion homeostasis|calcium ion transport|cardiac muscle cell apoptotic process|calcium ion homeostasis|negative regulation of cardiac muscle cell apoptotic process|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K06276 3-phosphoinositide dependent protein kinase-1[2.7.11.1] hsa04151|hsa05205|hsa04510|hsa04210|hsa04910|hsa04068|hsa05160|hsa04152|hsa04722|hsa04071|hsa05145|hsa04919|hsa04931|hsa04660|hsa05231|hsa05215|hsa03320|hsa04664|hsa04150|hsa05223|hsa05213|hsa04960 PI3K-Akt signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Aldosterone-regulated sodium reabsorption - Homo sapiens (human) 16:2537964-2603188 148 150 189 1426 1597 1454 0.567734877601449 0.522944431228873 0.653674157255262 4.90119404247116 5.02640611945747 5.2273103394941 0.581451155361861 5.05163683380758 -3.1190210176421 6.986966453186e-49 9.06908245623543e-46 DOWN ENSG00000132549 VPS13B vacuolar protein sorting 13 homolog B (yeast) [Source:HGNC Symbol;Acc:HGNC:2183] GO:0006810|GO:0045184|GO:0008104|GO:0015031 transport|establishment of protein localization|protein localization|protein transport - - - - 8:99013266-99877580 102 114 163 1247 1386 1467 0.386498538968145 0.392583696004603 0.55686319412216 4.233622364202 4.30902490171686 5.20963080495672 0.445315143031636 4.58409269029186 -3.36373763879917 1.41736799681227e-48 1.76308767403472e-45 DOWN ENSG00000143776 CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) [Source:HGNC Symbol;Acc:HGNC:1737] GO:0040011|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0005911|GO:0016043|GO:0043227|GO:0031252|GO:0005622|GO:0005515|GO:0016740|GO:0042802|GO:0043168|GO:0001882|GO:0016772|GO:0031982|GO:0043169|GO:0005737|GO:0006928|GO:0007154|GO:0016477|GO:0007165|GO:0070062|GO:0000166|GO:0030029|GO:0019538|GO:0006996|GO:0046872|GO:0035639|GO:0043412|GO:0007010|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0030036|GO:0042641|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0016773|GO:0005856|GO:0015629|GO:0031532|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0031032|GO:0006464|GO:0006468|GO:0004674 locomotion|signaling|cell|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|cell-cell junction|cellular component organization|membrane-bounded organelle|cell leading edge|intracellular|protein binding|transferase activity|identical protein binding|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|cation binding|cytoplasm|movement of cell or subcellular component|cell communication|cell migration|signal transduction|extracellular exosome|nucleotide binding|actin filament-based process|protein metabolic process|organelle organization|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|actin cytoskeleton organization|actomyosin|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|actin cytoskeleton|actin cytoskeleton reorganization|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|actomyosin structure organization|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 1:226989865-227318474 135 132 199 1563 1569 1647 0.427421971809602 0.37981934806361 0.56805711125925 4.43384237840615 4.07581487452427 4.88704247098199 0.458432810377487 4.46556657463747 -3.28406102313124 4.26487726670927e-48 5.09294583681354e-45 DOWN ENSG00000101868 POLA1 polymerase (DNA directed), alpha 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9173] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0019222|GO:0016032|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0051536|GO:0003676|GO:0034641|GO:0016788|GO:0001882|GO:0016772|GO:0046483|GO:0033554|GO:0043231|GO:0000723|GO:0043169|GO:0019899|GO:0005737|GO:0005635|GO:0042592|GO:0046983|GO:0019725|GO:0003682|GO:0006139|GO:0000166|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0003677|GO:0051539|GO:0010468|GO:0034645|GO:0046872|GO:0010833|GO:1903047|GO:0046982|GO:0051252|GO:0000722|GO:0044770|GO:0006302|GO:0033260|GO:0000278|GO:0005657|GO:0031981|GO:0004518|GO:1990234|GO:0005654|GO:0006259|GO:0016363|GO:0005694|GO:0000228|GO:0019900|GO:0032201|GO:0010467|GO:0009059|GO:0034399|GO:0016779|GO:0016070|GO:0005634|GO:0006974|GO:0000083|GO:0006303|GO:0006270|GO:0034061|GO:0032200|GO:0006260|GO:0043596|GO:0005658|GO:0032774|GO:0044772|GO:2001141|GO:0006273|GO:0022616|GO:0006269|GO:0004527|GO:0006310|GO:0090305|GO:0019901|GO:0006272|GO:0071897|GO:0006351|GO:0006355|GO:0006366|GO:0006271|GO:0003899|GO:0006357|GO:0006261|GO:0008408|GO:1903506|GO:0006312|GO:0000082|GO:0003887|GO:0003896 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|endomembrane system|transferase activity|regulation of metabolic process|viral process|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|iron-sulfur cluster binding|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|telomere maintenance|cation binding|enzyme binding|cytoplasm|nuclear envelope|homeostatic process|protein dimerization activity|cellular homeostasis|chromatin binding|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|DNA binding|4 iron, 4 sulfur cluster binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|telomere maintenance via telomere lengthening|mitotic cell cycle process|protein heterodimerization activity|regulation of RNA metabolic process|telomere maintenance via recombination|cell cycle phase transition|double-strand break repair|nuclear DNA replication|mitotic cell cycle|replication fork|nuclear lumen|nuclease activity|transferase complex|nucleoplasm|DNA metabolic process|nuclear matrix|chromosome|nuclear chromosome|kinase binding|telomere maintenance via semi-conservative replication|gene expression|macromolecule biosynthetic process|nuclear periphery|nucleotidyltransferase activity|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|regulation of transcription involved in G1/S transition of mitotic cell cycle|double-strand break repair via nonhomologous end joining|DNA replication initiation|DNA polymerase activity|telomere organization|DNA replication|nuclear replication fork|alpha DNA polymerase:primase complex|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|lagging strand elongation|DNA strand elongation|DNA replication, synthesis of RNA primer|exonuclease activity|DNA recombination|nucleic acid phosphodiester bond hydrolysis|protein kinase binding|leading strand elongation|DNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA strand elongation involved in DNA replication|DNA-directed RNA polymerase activity|regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication|3'-5' exonuclease activity|regulation of nucleic acid-templated transcription|mitotic recombination|G1/S transition of mitotic cell cycle|DNA-directed DNA polymerase activity|DNA primase activity K02320 DNA polymerase alpha subunit A[2.7.7.7] hsa01100|hsa00230|hsa00240|hsa03030 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|DNA replication - Homo sapiens (human) X:24693919-24996986 76 74 79 1083 1276 832 0.664033575575116 0.587606269003352 0.622327814378676 8.47815255168754 9.14732110372041 6.81282742042994 0.624655886319048 8.14610035861263 -3.70497603383987 1.10950026604288e-47 1.22677855342386e-44 DOWN ENSG00000164292 RHOBTB3 Rho-related BTB domain containing 3 [Source:HGNC Symbol;Acc:HGNC:18757] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0043168|GO:0001882|GO:0031982|GO:0016817|GO:0043231|GO:0019899|GO:0005737|GO:0007154|GO:0007165|GO:0070062|GO:0051649|GO:0000166|GO:0005794|GO:0016192|GO:0035639|GO:0001883|GO:0016818|GO:0046907|GO:0032549|GO:0035556|GO:0017076|GO:0051020|GO:0032561|GO:0005524|GO:0042147|GO:0030554|GO:0016482|GO:0016197|GO:0031267|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0017016|GO:0017111|GO:0017137|GO:0016887 signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|cellular localization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|endomembrane system|transport|anion binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|cell communication|signal transduction|extracellular exosome|establishment of localization in cell|nucleotide binding|Golgi apparatus|vesicle-mediated transport|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|GTPase binding|guanyl ribonucleotide binding|ATP binding|retrograde transport, endosome to Golgi|adenyl nucleotide binding|cytosolic transport|endosomal transport|small GTPase binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|Ras GTPase binding|nucleoside-triphosphatase activity|Rab GTPase binding|ATPase activity - - - - 5:95713522-95824383 195 239 384 3149 3371 3577 1.05885271005655 1.17945003619832 1.87994968014129 15.3204578572015 15.0185529950758 18.2032600970881 1.37275080879872 16.1807569831218 -3.55913743643535 1.08325931573421e-47 1.22677855342386e-44 DOWN ENSG00000198815 FOXJ3 forkhead box J3 [Source:HGNC Symbol;Acc:HGNC:29178] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 1:42176539-42335877 157 175 233 1697 1854 1892 0.949445698895327 0.961811429297686 1.27040429163791 9.19498026800188 9.19917799295475 10.7231217825068 1.06055380661031 9.70576001448781 -3.19402337127367 8.19192319232265e-47 8.73434553512859e-44 DOWN ENSG00000188153 COL4A5 collagen, type IV, alpha 5 [Source:HGNC Symbol;Acc:HGNC:2207] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0045202|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005604|GO:0005201|GO:0031594|GO:0043229|GO:0005578|GO:0071704|GO:0009056|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0005622|GO:0043234|GO:0012505|GO:0005605|GO:0048856|GO:0005587|GO:0006935|GO:0048468|GO:0007275|GO:0043062|GO:0043231|GO:0005737|GO:0006928|GO:0044236|GO:0005783|GO:0050808|GO:0030030|GO:0048869|GO:0005581|GO:0000902|GO:0031175|GO:0030574|GO:0044259|GO:0022617|GO:0007528|GO:0000904|GO:0032990|GO:0005788|GO:0007399|GO:0097485|GO:0030198|GO:0030154|GO:0048858|GO:0048666|GO:0030182|GO:0007411|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0032963|GO:0007409|GO:0048699 locomotion|developmental process|extracellular matrix|macromolecular complex|synapse|structural molecule activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|basement membrane|extracellular matrix structural constituent|neuromuscular junction|intracellular organelle|proteinaceous extracellular matrix|organic substance metabolic process|catabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|intracellular|protein complex|endomembrane system|basal lamina|anatomical structure development|collagen type IV trimer|chemotaxis|cell development|multicellular organism development|extracellular structure organization|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|multicellular organism metabolic process|endoplasmic reticulum|synapse organization|cell projection organization|cellular developmental process|collagen trimer|cell morphogenesis|neuron projection development|collagen catabolic process|multicellular organismal macromolecule metabolic process|extracellular matrix disassembly|neuromuscular junction development|cell morphogenesis involved in differentiation|cell part morphogenesis|endoplasmic reticulum lumen|nervous system development|neuron projection guidance|extracellular matrix organization|cell differentiation|cell projection morphogenesis|neuron development|neuron differentiation|axon guidance|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|collagen metabolic process|axonogenesis|generation of neurons K06237 collagen, type IV, alpha[-] hsa05200|hsa04151|hsa04510|hsa04933|hsa05146|hsa04974|hsa05222|hsa04512 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) X:108439844-108697545 80 60 130 1354 1444 1881 0.462824084374646 0.315468890549126 0.678085099739228 7.0184664357661 6.85426441738934 10.1986703013067 0.485459358221 8.02380038482071 -4.04686328920154 9.88108500126782e-47 1.01720659182017e-43 DOWN ENSG00000090905 TNRC6A trinucleotide repeat containing 6A [Source:HGNC Symbol;Acc:HGNC:11969] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0019222|GO:0045087|GO:0003676|GO:0034641|GO:0006952|GO:0043231|GO:0005737|GO:0030529|GO:0009890|GO:0016458|GO:0050776|GO:0007154|GO:0007165|GO:0000166|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0005794|GO:0071774|GO:0035770|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0035068|GO:0007166|GO:0031047|GO:0010629|GO:0032269|GO:0031981|GO:0044344|GO:0070848|GO:0005654|GO:0002764|GO:0043603|GO:0035556|GO:0044267|GO:0010467|GO:0071310|GO:0051246|GO:0009059|GO:0005634|GO:0036464|GO:0016441|GO:0043043|GO:0008543|GO:0017148|GO:0071363|GO:0010608|GO:0002768|GO:0038179|GO:0006412|GO:0048017|GO:0040029|GO:0007167|GO:0006417|GO:0044822|GO:0007219|GO:0035194|GO:0000932|GO:0048011|GO:0048015|GO:0038093|GO:0035195|GO:0007169|GO:0038095|GO:0035278|GO:0038127|GO:0007173 macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of immune system process|protein binding|endomembrane system|regulation of metabolic process|innate immune response|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|negative regulation of biosynthetic process|gene silencing|regulation of immune response|cell communication|signal transduction|nucleotide binding|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|response to fibroblast growth factor|ribonucleoprotein granule|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|micro-ribonucleoprotein complex|cell surface receptor signaling pathway|gene silencing by RNA|negative regulation of gene expression|negative regulation of cellular protein metabolic process|nuclear lumen|cellular response to fibroblast growth factor stimulus|response to growth factor|nucleoplasm|immune response-regulating signaling pathway|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|cellular response to organic substance|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|cytoplasmic ribonucleoprotein granule|posttranscriptional gene silencing|peptide biosynthetic process|fibroblast growth factor receptor signaling pathway|negative regulation of translation|cellular response to growth factor stimulus|posttranscriptional regulation of gene expression|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|translation|inositol lipid-mediated signaling|regulation of gene expression, epigenetic|enzyme linked receptor protein signaling pathway|regulation of translation|poly(A) RNA binding|Notch signaling pathway|posttranscriptional gene silencing by RNA|cytoplasmic mRNA processing body|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|Fc receptor signaling pathway|gene silencing by miRNA|transmembrane receptor protein tyrosine kinase signaling pathway|Fc-epsilon receptor signaling pathway|miRNA mediated inhibition of translation|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 16:24729695-24827632 82 89 178 1740 1922 1650 0.273837088355449 0.270116150962848 0.535937412047968 5.20625836463005 5.2662326890218 5.16406527426887 0.359963550455422 5.21218544264024 -3.8559656807694 2.19704840479121e-46 2.18635610255456e-43 DOWN ENSG00000188352 FOCAD focadhesin [Source:HGNC Symbol;Acc:HGNC:23377] GO:0016020|GO:0030054|GO:0005488|GO:0030055|GO:0031224|GO:0005515|GO:0005924|GO:0005912|GO:0016021|GO:0005925 membrane|cell junction|binding|cell-substrate junction|intrinsic component of membrane|protein binding|cell-substrate adherens junction|adherens junction|integral component of membrane|focal adhesion - - - - 9:20658309-20995955 41 47 54 708 729 590 0.226935972867528 0.236426731015191 0.269479503870797 3.51111931209311 3.31062932749827 3.06052628680609 0.244280735917839 3.29409164213249 -3.75326868995646 3.77752967220044e-46 3.6378829301249e-43 DOWN ENSG00000119681 LTBP2 latent transforming growth factor beta binding protein 2 [Source:HGNC Symbol;Acc:HGNC:6715] GO:0031012|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0005578|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0005615|GO:0005622|GO:0005515|GO:0008201|GO:0019838|GO:0006810|GO:0043168|GO:0043062|GO:0032940|GO:0031982|GO:0043169|GO:0071559|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0051649|GO:0005539|GO:0010033|GO:0046872|GO:0007166|GO:0015031|GO:0071560|GO:0046907|GO:0009306|GO:0070848|GO:0034613|GO:0046903|GO:0071310|GO:0030198|GO:0071363|GO:0006605|GO:0005509|GO:0007179|GO:0006886|GO:0007167|GO:0097435|GO:0007178|GO:0043206 extracellular matrix|signaling|cell|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|proteinaceous extracellular matrix|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|extracellular space|intracellular|protein binding|heparin binding|growth factor binding|transport|anion binding|extracellular structure organization|secretion by cell|vesicle|cation binding|response to transforming growth factor beta|establishment of protein localization|protein localization|cell communication|signal transduction|extracellular exosome|establishment of localization in cell|glycosaminoglycan binding|response to organic substance|metal ion binding|cell surface receptor signaling pathway|protein transport|cellular response to transforming growth factor beta stimulus|intracellular transport|protein secretion|response to growth factor|cellular protein localization|secretion|cellular response to organic substance|extracellular matrix organization|cellular response to growth factor stimulus|protein targeting|calcium ion binding|transforming growth factor beta receptor signaling pathway|intracellular protein transport|enzyme linked receptor protein signaling pathway|fibril organization|transmembrane receptor protein serine/threonine kinase signaling pathway|extracellular fibril organization - - - - 14:74498170-74612378 255 335 447 3041 3534 3635 1.42569449997181 1.7022033371124 2.25324230449438 15.2335334159707 16.2114186964375 19.046706934392 1.7937133805262 16.8305530156001 -3.23006129736122 1.13852988298881e-45 1.06217722271087e-42 DOWN ENSG00000091129 NRCAM neuronal cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:7994] GO:0040011|GO:0032502|GO:0040007|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0042995|GO:0050794|GO:0016049|GO:0009986|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0040008|GO:0009605|GO:0031224|GO:0050793|GO:0048589|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0048514|GO:0016337|GO:0042391|GO:0006935|GO:0045595|GO:0009897|GO:0048468|GO:0001568|GO:0007275|GO:0050877|GO:0032535|GO:0051128|GO:0022607|GO:0098609|GO:0005887|GO:0045597|GO:0006928|GO:0043005|GO:0008037|GO:0031226|GO:0001525|GO:0008104|GO:0007154|GO:0061024|GO:0016477|GO:0048588|GO:0048638|GO:0050808|GO:0008092|GO:0030030|GO:0048869|GO:0016021|GO:0001558|GO:0060560|GO:0030506|GO:0000902|GO:0031175|GO:0031344|GO:0007416|GO:0030424|GO:0001944|GO:0072358|GO:0007417|GO:0019227|GO:0010720|GO:0043194|GO:0000904|GO:0001508|GO:0098632|GO:0001764|GO:0044304|GO:0045161|GO:0050769|GO:0019226|GO:0008361|GO:0008038|GO:0022604|GO:0034113|GO:0030516|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0048469|GO:0072359|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0042551|GO:0086080|GO:0010769|GO:0007413|GO:0061564|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0048675|GO:0045666|GO:0045162|GO:0007409|GO:0048699|GO:0031290|GO:0050770|GO:0045664 locomotion|developmental process|growth|synapse|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|cell projection|regulation of cellular process|cell growth|cell surface|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|regulation of growth|response to external stimulus|intrinsic component of membrane|regulation of developmental process|developmental growth|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|single organismal cell-cell adhesion|regulation of membrane potential|chemotaxis|regulation of cell differentiation|external side of plasma membrane|cell development|blood vessel development|multicellular organism development|neurological system process|regulation of cellular component size|regulation of cellular component organization|cellular component assembly|cell-cell adhesion|integral component of plasma membrane|positive regulation of cell differentiation|movement of cell or subcellular component|neuron projection|cell recognition|intrinsic component of plasma membrane|angiogenesis|protein localization|cell communication|membrane organization|cell migration|developmental cell growth|regulation of developmental growth|synapse organization|cytoskeletal protein binding|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell growth|developmental growth involved in morphogenesis|ankyrin binding|cell morphogenesis|neuron projection development|regulation of cell projection organization|synapse assembly|axon|vasculature development|cardiovascular system development|central nervous system development|neuronal action potential propagation|positive regulation of cell development|axon initial segment|cell morphogenesis involved in differentiation|action potential|protein binding involved in cell-cell adhesion|neuron migration|main axon|neuronal ion channel clustering|positive regulation of neurogenesis|transmission of nerve impulse|regulation of cell size|neuron recognition|regulation of cell morphogenesis|heterotypic cell-cell adhesion|regulation of axon extension|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|cell maturation|circulatory system development|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|neuron maturation|protein binding involved in heterotypic cell-cell adhesion|regulation of cell morphogenesis involved in differentiation|axonal fasciculation|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|axon extension|positive regulation of neuron differentiation|clustering of voltage-gated sodium channels|axonogenesis|generation of neurons|retinal ganglion cell axon guidance|regulation of axonogenesis|regulation of neuron differentiation K06756 neuronal cell adhesion molecule[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 7:108147623-108456717 14 8 16 355 399 479 0.0566586270509302 0.0294237894978292 0.0583814195290015 1.28722840642988 1.32486017129928 1.81674532242691 0.0481546120259203 1.47627796671869 -4.93814660083586 2.50807776333909e-45 2.26549519778694e-42 DOWN ENSG00000261796 ISY1-RAB43 ISY1-RAB43 readthrough [Source:HGNC Symbol;Acc:HGNC:42969] - - K12870 pre-mRNA-splicing factor ISY1[-] hsa03040 Spliceosome - Homo sapiens (human) 3:129087575-129161036 0 0 0 222 221 397 0 0 0 2.89032466130505 2.63485040427141 5.40648216972534 0 3.6438857451006 -Inf 2.5801177974394e-45 2.26549519778694e-42 DOWN ENSG00000137200 CMTR1 cap methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:21077] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0008168|GO:0043412|GO:0001510|GO:0031981|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0009451|GO:0016071|GO:0080009|GO:0008171|GO:0008173|GO:0008757|GO:0016556|GO:0004483|GO:0006397|GO:0097309|GO:0006370|GO:0009452 cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|methyltransferase activity|macromolecule modification|RNA methylation|nuclear lumen|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|RNA modification|mRNA metabolic process|mRNA methylation|O-methyltransferase activity|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|mRNA modification|mRNA (nucleoside-2'-O-)-methyltransferase activity|mRNA processing|cap1 mRNA methylation|7-methylguanosine mRNA capping|7-methylguanosine RNA capping - - - - 6:37433219-37482827 26 24 55 717 696 660 0.301399360472171 0.252850745640391 0.574843123121704 7.44715905295271 6.61989019895597 7.17045104159706 0.376364409744755 7.07916676450191 -4.23337744786834 2.3693214900175e-44 2.02096353608521e-41 DOWN ENSG00000174851 YIF1A Yip1 interacting factor homolog A (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:16688] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0006810|GO:0033554|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0016021|GO:0019538|GO:0010033|GO:0005794|GO:0016192|GO:0030968|GO:0005793|GO:0005815|GO:0015031|GO:0006986|GO:0044267|GO:0071310|GO:0000139|GO:0035967|GO:0034976|GO:0005856|GO:0034620|GO:0036498|GO:0015630 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|transport|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|endoplasmic reticulum|integral component of membrane|protein metabolic process|response to organic substance|Golgi apparatus|vesicle-mediated transport|endoplasmic reticulum unfolded protein response|endoplasmic reticulum-Golgi intermediate compartment|microtubule organizing center|protein transport|response to unfolded protein|cellular protein metabolic process|cellular response to organic substance|Golgi membrane|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|cytoskeleton|cellular response to unfolded protein|IRE1-mediated unfolded protein response|microtubule cytoskeleton - - - - 11:66284580-66289170 67 72 107 862 945 1002 0.811259950504656 0.79231183664721 1.16810761601575 9.35166647020579 9.38823941769894 11.3705302713148 0.923893134389205 10.0368120530732 -3.44143130867625 2.51511402210604e-44 2.08572816710982e-41 DOWN ENSG00000088448 ANKRD10 ankyrin repeat domain 10 [Source:HGNC Symbol;Acc:HGNC:20265] GO:0023052|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0005515|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0030111|GO:0007166|GO:0016055|GO:0060828|GO:0060070 signaling|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|protein binding|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|regulation of Wnt signaling pathway|cell surface receptor signaling pathway|Wnt signaling pathway|regulation of canonical Wnt signaling pathway|canonical Wnt signaling pathway - - - - 13:110878540-110915069 44 38 98 1123 1227 1552 0.42368762477771 0.332550705010161 0.850818894496386 9.6888501285766 9.69409665837391 14.0060415724941 0.535685741428086 11.1296627864815 -4.37687917568566 2.72841090987884e-44 2.15898886272975e-41 DOWN ENSG00000151012 SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 [Source:HGNC Symbol;Acc:HGNC:11059] GO:0040011|GO:0032502|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0022857|GO:0043229|GO:0006950|GO:0050900|GO:0009986|GO:0048870|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0050817|GO:0016337|GO:0009888|GO:0006810|GO:0002088|GO:0007275|GO:0048513|GO:0007420|GO:0098609|GO:0043231|GO:0010243|GO:0005737|GO:0009611|GO:0060322|GO:0007423|GO:0006928|GO:0001775|GO:0022891|GO:0006979|GO:0055085|GO:0016477|GO:0005783|GO:0048869|GO:0016021|GO:0010033|GO:0050878|GO:0009636|GO:0030168|GO:0001654|GO:0007417|GO:0007596|GO:0034109|GO:1903825|GO:0042060|GO:0005791|GO:0006811|GO:0015075|GO:0043279|GO:0007599|GO:0070306|GO:0014070|GO:0060429|GO:0007399|GO:0030154|GO:0005856|GO:0034220|GO:0006820|GO:0015711|GO:0098656|GO:0070527|GO:0030855|GO:0043010|GO:0015297|GO:0008509|GO:0015327|GO:0046942|GO:0046943|GO:0035094|GO:0006865|GO:0015171|GO:0006835|GO:0003333|GO:0015301|GO:0015807|GO:0008514|GO:0005310|GO:0015813|GO:0015175|GO:0005313|GO:1902475|GO:0015179|GO:0089711 locomotion|developmental process|transporter activity|immune system process|cell|membrane|cellular process|response to stimulus|binding|transmembrane transporter activity|intracellular organelle|response to stress|leukocyte migration|cell surface|cell motility|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|coagulation|single organismal cell-cell adhesion|tissue development|transport|lens development in camera-type eye|multicellular organism development|animal organ development|brain development|cell-cell adhesion|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|response to wounding|head development|sensory organ development|movement of cell or subcellular component|cell activation|substrate-specific transmembrane transporter activity|response to oxidative stress|transmembrane transport|cell migration|endoplasmic reticulum|cellular developmental process|integral component of membrane|response to organic substance|regulation of body fluid levels|response to toxic substance|platelet activation|eye development|central nervous system development|blood coagulation|homotypic cell-cell adhesion|organic acid transmembrane transport|wound healing|rough endoplasmic reticulum|ion transport|ion transmembrane transporter activity|response to alkaloid|hemostasis|lens fiber cell differentiation|response to organic cyclic compound|epithelium development|nervous system development|cell differentiation|cytoskeleton|ion transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|platelet aggregation|epithelial cell differentiation|camera-type eye development|antiporter activity|anion transmembrane transporter activity|cystine:glutamate antiporter activity|carboxylic acid transport|carboxylic acid transmembrane transporter activity|response to nicotine|amino acid transport|amino acid transmembrane transporter activity|dicarboxylic acid transport|amino acid transmembrane transport|anion:anion antiporter activity|L-amino acid transport|organic anion transmembrane transporter activity|dicarboxylic acid transmembrane transporter activity|L-glutamate transport|neutral amino acid transmembrane transporter activity|L-glutamate transmembrane transporter activity|L-alpha-amino acid transmembrane transport|L-amino acid transmembrane transporter activity|L-glutamate transmembrane transport - - - - 4:138164097-138242349 416 621 444 5540 7097 4912 2.98292485214024 4.04687734574354 2.8704227931728 35.5923022374694 41.7533578143349 33.0092732904799 3.30007499701886 36.7849777807614 -3.47854600349501 2.74809328008745e-44 2.15898886272975e-41 DOWN ENSG00000073350 LLGL2 lethal giant larvae homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:6629] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0060341|GO:0007049|GO:0051640|GO:0006810|GO:0022402|GO:0005938|GO:0007275|GO:0008047|GO:0032940|GO:0043231|GO:0019899|GO:0005737|GO:0032880|GO:0051656|GO:0009966|GO:0045184|GO:0019904|GO:0010646|GO:0043085|GO:0008104|GO:0007163|GO:0007154|GO:0007165|GO:0051649|GO:0050790|GO:0051301|GO:0048869|GO:0030029|GO:0032878|GO:0007017|GO:0006996|GO:0016192|GO:0051653|GO:0005096|GO:0030864|GO:0007166|GO:0007010|GO:0051345|GO:0030695|GO:0051223|GO:0030165|GO:0015031|GO:0006887|GO:0070201|GO:0051046|GO:0031981|GO:0030010|GO:0009306|GO:0008593|GO:0005654|GO:0030036|GO:0051293|GO:0007399|GO:0046903|GO:0051020|GO:0030154|GO:0000226|GO:0005856|GO:0005634|GO:0015629|GO:0030866|GO:0051294|GO:0050708|GO:0043087|GO:0043547|GO:0030865|GO:0031267|GO:0007219|GO:0022008|GO:0030863|GO:0017016|GO:0017137 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|regulation of cellular localization|cell cycle|organelle localization|transport|cell cycle process|cell cortex|multicellular organism development|enzyme activator activity|secretion by cell|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of protein localization|establishment of organelle localization|regulation of signal transduction|establishment of protein localization|protein domain specific binding|regulation of cell communication|positive regulation of catalytic activity|protein localization|establishment or maintenance of cell polarity|cell communication|signal transduction|establishment of localization in cell|regulation of catalytic activity|cell division|cellular developmental process|actin filament-based process|regulation of establishment or maintenance of cell polarity|microtubule-based process|organelle organization|vesicle-mediated transport|spindle localization|GTPase activator activity|cortical actin cytoskeleton|cell surface receptor signaling pathway|cytoskeleton organization|positive regulation of hydrolase activity|GTPase regulator activity|regulation of protein transport|PDZ domain binding|protein transport|exocytosis|regulation of establishment of protein localization|regulation of secretion|nuclear lumen|establishment of cell polarity|protein secretion|regulation of Notch signaling pathway|nucleoplasm|actin cytoskeleton organization|establishment of spindle localization|nervous system development|secretion|GTPase binding|cell differentiation|microtubule cytoskeleton organization|cytoskeleton|nucleus|actin cytoskeleton|cortical actin cytoskeleton organization|establishment of spindle orientation|regulation of protein secretion|regulation of GTPase activity|positive regulation of GTPase activity|cortical cytoskeleton organization|small GTPase binding|Notch signaling pathway|neurogenesis|cortical cytoskeleton|Ras GTPase binding|Rab GTPase binding K06094 lethal(2) giant larvae protein[-] hsa04390|hsa04530 Hippo signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human) 17:75525080-75575208 105 113 193 1366 1482 1643 0.568060309351913 0.555601954844568 0.941404487019035 6.6214374931688 6.5783987562556 8.3304902413131 0.688355583738505 7.1767754969125 -3.38210987584066 9.8245752027241e-44 7.52058636159296e-41 DOWN ENSG00000130638 ATXN10 ataxin 10 [Source:HGNC Symbol;Acc:HGNC:10549] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0042995|GO:0044297|GO:0009653|GO:0016043|GO:0071944|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0042802|GO:0048468|GO:0043025|GO:0007275|GO:0022607|GO:0019899|GO:0005737|GO:0043005|GO:0036477|GO:0030030|GO:0048869|GO:0006996|GO:0000902|GO:0005829|GO:0031175|GO:0044782|GO:0030031|GO:0030425|GO:0048471|GO:0006461|GO:0070925|GO:0042384|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0048666|GO:0030182|GO:0060271|GO:0051259|GO:0022008|GO:0048699|GO:0070206|GO:0051260|GO:0070207 developmental process|cell|membrane|cellular process|extracellular region|binding|cell projection|cell body|anatomical structure morphogenesis|cellular component organization|cell periphery|extracellular space|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|identical protein binding|cell development|neuronal cell body|multicellular organism development|cellular component assembly|enzyme binding|cytoplasm|neuron projection|somatodendritic compartment|cell projection organization|cellular developmental process|organelle organization|cell morphogenesis|cytosol|neuron projection development|cilium organization|cell projection assembly|dendrite|perinuclear region of cytoplasm|protein complex assembly|organelle assembly|cilium assembly|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|neuron development|neuron differentiation|cilium morphogenesis|protein oligomerization|neurogenesis|generation of neurons|protein trimerization|protein homooligomerization|protein homotrimerization - - - - 22:45671798-45845307 322 351 491 3191 3638 3018 2.87410314756991 2.84730264408975 3.9513172461785 25.5194286534797 26.642628335066 25.2461177934506 3.22424101261272 25.8027249273321 -3.00049193648211 1.0284398914845e-43 7.67576113009459e-41 DOWN ENSG00000103550 KNOP1 lysine-rich nucleolar protein 1 [Source:HGNC Symbol;Acc:HGNC:34404] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 16:19701934-19718235 58 51 107 971 1046 951 0.430147351000238 0.34374951045192 0.715462853089117 6.4521623023008 6.36484832510629 6.60994356576378 0.496453238180425 6.47565139772362 -3.70529558421896 8.79290397770393e-43 6.40252086220422e-40 DOWN ENSG00000143398 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha [Source:HGNC Symbol;Acc:HGNC:8994] GO:0040011|GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0030055|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0031252|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0044255|GO:0006935|GO:0009888|GO:0006810|GO:0007275|GO:0048513|GO:0043168|GO:0005924|GO:0044281|GO:0005912|GO:0001882|GO:0016772|GO:0019637|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0005849|GO:0001726|GO:0006928|GO:0031589|GO:0030027|GO:0045184|GO:0043085|GO:0008104|GO:0007154|GO:0061024|GO:0006629|GO:0016477|GO:0007165|GO:0051649|GO:0031256|GO:0050790|GO:0000166|GO:0030030|GO:0031253|GO:0048869|GO:0030029|GO:0044249|GO:0010256|GO:0006996|GO:0016192|GO:0006909|GO:0005829|GO:0008654|GO:0045216|GO:0090150|GO:0046486|GO:0035639|GO:0007010|GO:0051345|GO:0001883|GO:0015031|GO:0001667|GO:0007009|GO:0007160|GO:0046907|GO:0032549|GO:0034329|GO:0072657|GO:0031981|GO:0060326|GO:0030031|GO:0005654|GO:0016301|GO:0043588|GO:0030036|GO:0034613|GO:0032587|GO:0019900|GO:0060429|GO:0006796|GO:0008610|GO:0017076|GO:0031529|GO:0030154|GO:0005847|GO:0030258|GO:0016773|GO:0005634|GO:0006644|GO:0005925|GO:0031532|GO:0030855|GO:0046474|GO:0034332|GO:0072659|GO:0090002|GO:0005524|GO:0030216|GO:0043087|GO:0030554|GO:0016310|GO:0006605|GO:0008544|GO:0016604|GO:0006886|GO:0043547|GO:0007044|GO:0016307|GO:0048041|GO:0097178|GO:0046834|GO:0006897|GO:1990778|GO:0006612|GO:0010761|GO:0006650|GO:0034333|GO:0016607|GO:0072661|GO:0090630|GO:0046854|GO:0046488|GO:0016308|GO:0006661|GO:0009913 locomotion|developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|cell-substrate junction|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell motility|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|cell leading edge|biosynthetic process|intracellular|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|cellular lipid metabolic process|chemotaxis|tissue development|transport|multicellular organism development|animal organ development|anion binding|cell-substrate adherens junction|small molecule metabolic process|adherens junction|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|mRNA cleavage factor complex|ruffle|movement of cell or subcellular component|cell-substrate adhesion|lamellipodium|establishment of protein localization|positive regulation of catalytic activity|protein localization|cell communication|membrane organization|lipid metabolic process|cell migration|signal transduction|establishment of localization in cell|leading edge membrane|regulation of catalytic activity|nucleotide binding|cell projection organization|cell projection membrane|cellular developmental process|actin filament-based process|cellular biosynthetic process|endomembrane system organization|organelle organization|vesicle-mediated transport|phagocytosis|cytosol|phospholipid biosynthetic process|cell-cell junction organization|establishment of protein localization to membrane|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|cytoskeleton organization|positive regulation of hydrolase activity|purine nucleoside binding|protein transport|ameboidal-type cell migration|plasma membrane organization|cell-matrix adhesion|intracellular transport|ribonucleoside binding|cell junction assembly|protein localization to membrane|nuclear lumen|cell chemotaxis|cell projection assembly|nucleoplasm|kinase activity|skin development|actin cytoskeleton organization|cellular protein localization|ruffle membrane|kinase binding|epithelium development|phosphate-containing compound metabolic process|lipid biosynthetic process|purine nucleotide binding|ruffle organization|cell differentiation|mRNA cleavage and polyadenylation specificity factor complex|lipid modification|phosphotransferase activity, alcohol group as acceptor|nucleus|phospholipid metabolic process|focal adhesion|actin cytoskeleton reorganization|epithelial cell differentiation|glycerophospholipid biosynthetic process|adherens junction organization|protein localization to plasma membrane|establishment of protein localization to plasma membrane|ATP binding|keratinocyte differentiation|regulation of GTPase activity|adenyl nucleotide binding|phosphorylation|protein targeting|epidermis development|nuclear body|intracellular protein transport|positive regulation of GTPase activity|cell-substrate junction assembly|phosphatidylinositol phosphate kinase activity|focal adhesion assembly|ruffle assembly|lipid phosphorylation|endocytosis|protein localization to cell periphery|protein targeting to membrane|fibroblast migration|glycerophospholipid metabolic process|adherens junction assembly|nuclear speck|protein targeting to plasma membrane|activation of GTPase activity|phosphatidylinositol phosphorylation|phosphatidylinositol metabolic process|1-phosphatidylinositol-4-phosphate 5-kinase activity|phosphatidylinositol biosynthetic process|epidermal cell differentiation K00889 1-phosphatidylinositol-4-phosphate 5-kinase[2.7.1.68] hsa01100|hsa04144|hsa04810|hsa04072|hsa05231|hsa04070|hsa04666|hsa00562 Metabolic pathways - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 1:151197949-151249536 191 176 206 1523 1661 1453 0.986689549559195 0.826302867590464 0.959464322614058 7.04928069455203 7.04019616824459 7.03463937156894 0.924152246587906 7.04137207812185 -2.92965413042408 2.33652588891043e-42 1.66082485446504e-39 DOWN ENSG00000151779 NBAS neuroblastoma amplified sequence [Source:HGNC Symbol;Acc:HGNC:15625] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0045184|GO:0000149|GO:0006139|GO:0008104|GO:0070939|GO:0005783|GO:0051649|GO:0016021|GO:0031324|GO:0031323|GO:0016192|GO:0051252|GO:0015031|GO:0044265|GO:0046907|GO:0019439|GO:0016070|GO:0006401|GO:0048193|GO:0016071|GO:0006402|GO:0006890|GO:0000956|GO:2000623|GO:0000184 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|SNARE binding|nucleobase-containing compound metabolic process|protein localization|Dsl1p complex|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|vesicle-mediated transport|regulation of RNA metabolic process|protein transport|cellular macromolecule catabolic process|intracellular transport|aromatic compound catabolic process|RNA metabolic process|RNA catabolic process|Golgi vesicle transport|mRNA metabolic process|mRNA catabolic process|retrograde vesicle-mediated transport, Golgi to ER|nuclear-transcribed mRNA catabolic process|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay - - - - 2:15166909-15561330 28 23 58 686 704 838 0.183627482245273 0.137088667947012 0.342950145323164 4.03094661314774 3.78813678187543 5.1506059507526 0.22122209850515 4.32322978192526 -4.2885421054699 6.29734997260427e-42 4.37211828097972e-39 DOWN ENSG00000278864 RP11-45M22.2 - - - - - - - 17:17181504-17183257 10 7 13 250 323 317 0.403270028210747 0.256580124977968 0.472680331687803 9.03346648005263 10.6877671848598 11.9812944153372 0.377510161625506 10.5675093600832 -4.80697610131126 9.68868252416133e-42 6.57377109264346e-39 DOWN ENSG00000197548 ATG7 autophagy related 7 [Source:HGNC Symbol;Acc:HGNC:16935] GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0006914|GO:0016043|GO:0051707|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0005929|GO:0019222|GO:0042802|GO:0016032|GO:0010507|GO:0010506|GO:0006810|GO:0010941|GO:0005930|GO:0009991|GO:0006952|GO:0031325|GO:0051128|GO:0033554|GO:0010942|GO:0098542|GO:0005737|GO:0010508|GO:0031668|GO:0009615|GO:0046983|GO:0045184|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0000422|GO:0008134|GO:0008219|GO:0044804|GO:0016236|GO:0051607|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0042594|GO:0055093|GO:0006996|GO:0051701|GO:0061025|GO:0019048|GO:0032268|GO:0005829|GO:0044805|GO:0045732|GO:0034645|GO:0019054|GO:1903008|GO:0071455|GO:0043412|GO:0030163|GO:0007005|GO:0015031|GO:1903146|GO:0036211|GO:0016239|GO:0039521|GO:0016241|GO:0042157|GO:0010324|GO:0051247|GO:0034727|GO:0009267|GO:0071453|GO:0032270|GO:0008641|GO:0012501|GO:0033043|GO:0044267|GO:0042176|GO:0051246|GO:0009059|GO:0000407|GO:0043068|GO:0031669|GO:0031667|GO:0042803|GO:0043067|GO:0006995|GO:0031401|GO:0043065|GO:0004839|GO:0010821|GO:0042158|GO:0042981|GO:0006464|GO:0019779|GO:0019778|GO:0006915|GO:0043687|GO:0006497|GO:0032446|GO:0006501|GO:0016567 immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|autophagy|cellular component organization|response to other organism|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|ligase activity|intracellular|protein binding|cilium|regulation of metabolic process|identical protein binding|viral process|negative regulation of autophagy|regulation of autophagy|transport|regulation of cell death|axoneme|response to extracellular stimulus|defense response|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of cell death|defense response to other organism|cytoplasm|positive regulation of autophagy|cellular response to extracellular stimulus|response to virus|protein dimerization activity|establishment of protein localization|regulation of cell communication|protein localization|cell communication|membrane organization|mitophagy|transcription factor binding|cell death|nucleophagy|macroautophagy|defense response to virus|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to starvation|response to hyperoxia|organelle organization|interaction with host|membrane fusion|modulation by virus of host morphology or physiology|regulation of cellular protein metabolic process|cytosol|late nucleophagy|positive regulation of protein catabolic process|cellular macromolecule biosynthetic process|modulation by virus of host process|organelle disassembly|cellular response to hyperoxia|macromolecule modification|protein catabolic process|mitochondrion organization|protein transport|regulation of mitophagy|protein modification process|positive regulation of macroautophagy|suppression by virus of host autophagy|regulation of macroautophagy|lipoprotein metabolic process|membrane invagination|positive regulation of protein metabolic process|piecemeal microautophagy of nucleus|cellular response to starvation|cellular response to oxygen levels|positive regulation of cellular protein metabolic process|small protein activating enzyme activity|programmed cell death|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|pre-autophagosomal structure|positive regulation of programmed cell death|cellular response to nutrient levels|response to nutrient levels|protein homodimerization activity|regulation of programmed cell death|cellular response to nitrogen starvation|positive regulation of protein modification process|positive regulation of apoptotic process|ubiquitin activating enzyme activity|regulation of mitochondrion organization|lipoprotein biosynthetic process|regulation of apoptotic process|cellular protein modification process|Atg8 activating enzyme activity|Atg12 activating enzyme activity|apoptotic process|post-translational protein modification|protein lipidation|protein modification by small protein conjugation|C-terminal protein lipidation|protein ubiquitination K08337 ubiquitin-like modifier-activating enzyme ATG7[-] hsa04140 Regulation of autophagy - Homo sapiens (human) 3:11272309-11557665 54 46 102 996 1099 864 0.318052554708377 0.246229466747477 0.541645383730522 5.25605439595419 5.31090238099991 4.76919872730137 0.368642468395459 5.11205183475182 -3.79360827768773 2.09203326612642e-41 1.3879013583764e-38 DOWN ENSG00000136643 RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:10439] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0043168|GO:0005543|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0000166|GO:0019538|GO:0005768|GO:0035639|GO:0043412|GO:0005769|GO:0035091|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|lipid binding|intracellular|protein binding|endomembrane system|transferase activity|anion binding|phospholipid binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|nucleotide binding|protein metabolic process|endosome|purine ribonucleoside triphosphate binding|macromolecule modification|early endosome|phosphatidylinositol binding|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 1:213051233-213274773 32 53 78 748 793 802 0.288137288217805 0.433714031930824 0.63321723001988 6.0345309056277 5.85848548536868 6.7678038294575 0.451689516722836 6.22027340681796 -3.78357465846193 4.22932371411686e-41 2.74483109046184e-38 DOWN ENSG00000001629 ANKIB1 ankyrin repeat and IBR domain containing 1 [Source:HGNC Symbol;Acc:HGNC:22215] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0031325|GO:0043169|GO:0019899|GO:0005737|GO:0019787|GO:0000151|GO:0019538|GO:0031323|GO:0032268|GO:0045732|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:1990234|GO:0051247|GO:0006508|GO:0032270|GO:0044267|GO:0044390|GO:0042176|GO:0051246|GO:0044257|GO:0061630|GO:0010498|GO:1903364|GO:0030162|GO:0045862|GO:0051603|GO:0046914|GO:0031624|GO:0006464|GO:1903052|GO:0019941|GO:1901800|GO:0061136|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0032436|GO:0042787|GO:0016567|GO:0000209 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|positive regulation of metabolic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|positive regulation of cellular metabolic process|cation binding|enzyme binding|cytoplasm|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|transferase complex|positive regulation of protein metabolic process|proteolysis|positive regulation of cellular protein metabolic process|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein catabolic process|regulation of protein metabolic process|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|positive regulation of cellular protein catabolic process|regulation of proteolysis|positive regulation of proteolysis|proteolysis involved in cellular protein catabolic process|transition metal ion binding|ubiquitin conjugating enzyme binding|cellular protein modification process|positive regulation of proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|regulation of proteasomal protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 7:92246234-92401384 239 241 361 2380 2478 3031 1.85781137862899 1.70255716766084 2.53003400107767 16.5759740511555 15.8042422366335 22.0810262897261 2.03013418245583 18.1537475258384 -3.16062040716903 4.48564110455194e-41 2.84924105394242e-38 DOWN ENSG00000076356 PLXNA2 plexin A2 [Source:HGNC Symbol;Acc:HGNC:9100] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0040012|GO:0016049|GO:0051641|GO:0050795|GO:0038023|GO:0048870|GO:0009653|GO:0016043|GO:0071944|GO:0040008|GO:0009605|GO:0031224|GO:0050793|GO:0048589|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0001756|GO:0006935|GO:0045595|GO:0051640|GO:0009888|GO:0048468|GO:0035295|GO:0007275|GO:0048513|GO:0032535|GO:0030902|GO:0051128|GO:0007420|GO:0005887|GO:0060174|GO:0004888|GO:0007389|GO:0060322|GO:0050920|GO:0043235|GO:0006928|GO:0021915|GO:0031226|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0048638|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0001558|GO:0060560|GO:0000902|GO:0031175|GO:0031344|GO:0017154|GO:0007166|GO:0007417|GO:0000904|GO:0009790|GO:0030334|GO:0060037|GO:0003002|GO:0008361|GO:0022604|GO:0002116|GO:0051642|GO:0060429|GO:0035108|GO:0030516|GO:0032990|GO:0007399|GO:0021535|GO:0097485|GO:0030154|GO:0048858|GO:0060173|GO:1902667|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0009792|GO:0010769|GO:0048841|GO:1902285|GO:0061564|GO:0061053|GO:0009952|GO:0071526|GO:0022008|GO:0048667|GO:0021934|GO:0050767|GO:0048812|GO:0035282|GO:0048675|GO:0007409|GO:0008045|GO:0048699|GO:1902287|GO:0021935|GO:0043009|GO:0048846|GO:0050770|GO:0045664|GO:0021785 locomotion|developmental process|growth|macromolecular complex|signal transducer activity|behavior|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|regulation of locomotion|cell growth|cellular localization|regulation of behavior|signaling receptor activity|cell motility|anatomical structure morphogenesis|cellular component organization|cell periphery|regulation of growth|response to external stimulus|intrinsic component of membrane|regulation of developmental process|developmental growth|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|somitogenesis|chemotaxis|regulation of cell differentiation|organelle localization|tissue development|cell development|tube development|multicellular organism development|animal organ development|regulation of cellular component size|hindbrain development|regulation of cellular component organization|brain development|integral component of plasma membrane|limb bud formation|transmembrane signaling receptor activity|pattern specification process|head development|regulation of chemotaxis|receptor complex|movement of cell or subcellular component|neural tube development|intrinsic component of plasma membrane|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|regulation of developmental growth|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|regulation of cell growth|developmental growth involved in morphogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|semaphorin receptor activity|cell surface receptor signaling pathway|central nervous system development|cell morphogenesis involved in differentiation|embryo development|regulation of cell migration|pharyngeal system development|regionalization|regulation of cell size|regulation of cell morphogenesis|semaphorin receptor complex|centrosome localization|epithelium development|limb morphogenesis|regulation of axon extension|cell part morphogenesis|nervous system development|cell migration in hindbrain|neuron projection guidance|cell differentiation|cell projection morphogenesis|limb development|regulation of axon guidance|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|embryo development ending in birth or egg hatching|regulation of cell morphogenesis involved in differentiation|regulation of axon extension involved in axon guidance|semaphorin-plexin signaling pathway involved in neuron projection guidance|axon development|somite development|anterior/posterior pattern specification|semaphorin-plexin signaling pathway|neurogenesis|cell morphogenesis involved in neuron differentiation|hindbrain tangential cell migration|regulation of neurogenesis|neuron projection morphogenesis|segmentation|axon extension|axonogenesis|motor neuron axon guidance|generation of neurons|semaphorin-plexin signaling pathway involved in axon guidance|cerebellar granule cell precursor tangential migration|chordate embryonic development|axon extension involved in axon guidance|regulation of axonogenesis|regulation of neuron differentiation|branchiomotor neuron axon guidance K06820 plexin A[-] hsa04360 Axon guidance - Homo sapiens (human) 1:208022242-208244320 87 101 170 1248 1335 1121 0.371625492195676 0.392092266584776 0.654710256402557 4.77636540389033 4.67880017681914 4.48765874272192 0.472809338394336 4.64760810781046 -3.2971579886145 1.19536112460002e-40 7.43464812787686e-38 DOWN ENSG00000160613 PCSK7 proprotein convertase subtilisin/kexin type 7 [Source:HGNC Symbol;Acc:HGNC:8748] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0042445|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0031228|GO:0034641|GO:0043231|GO:0008233|GO:0005737|GO:0016486|GO:0010817|GO:0016021|GO:0019538|GO:0031301|GO:0005794|GO:0017171|GO:0006518|GO:0051604|GO:0030173|GO:0006508|GO:0008236|GO:0043603|GO:0010467|GO:0000139|GO:0004252|GO:0016485|GO:0004175 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|intrinsic component of Golgi membrane|cellular nitrogen compound metabolic process|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|peptide hormone processing|regulation of hormone levels|integral component of membrane|protein metabolic process|integral component of organelle membrane|Golgi apparatus|serine hydrolase activity|peptide metabolic process|protein maturation|integral component of Golgi membrane|proteolysis|serine-type peptidase activity|cellular amide metabolic process|gene expression|Golgi membrane|serine-type endopeptidase activity|protein processing|endopeptidase activity - - - - 11:117204337-117232525 34 35 45 489 648 475 0.0810744534682423 0.0758498566467319 0.0967440491259566 1.04473888333873 1.26778208725124 1.0615094553325 0.0845561197469769 1.12467680864082 -3.73345749906794 1.6895517101472e-40 1.02938523989254e-37 DOWN ENSG00000123106 CCDC91 coiled-coil domain containing 91 [Source:HGNC Symbol;Acc:HGNC:24855] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0042802|GO:0006810|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0005794|GO:0015031|GO:0031981|GO:0005654|GO:0005634 cell|membrane|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|identical protein binding|transport|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|Golgi apparatus|protein transport|nuclear lumen|nucleoplasm|nucleus - - - - 12:28133249-28581511 55 64 88 681 804 725 0.327291294230783 0.346124954409056 0.472140580382209 3.63093446331988 3.92552089423231 4.04334397571971 0.381852276340683 3.8665997777573 -3.33997891311648 2.85023442072943e-40 1.70181796792913e-37 DOWN ENSG00000169519 METTL15 methyltransferase like 15 [Source:HGNC Symbol;Acc:HGNC:26606] GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0006807|GO:0071704|GO:0044237|GO:0031224|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0006139|GO:0016021|GO:0022613|GO:0008168|GO:0043412|GO:0042254|GO:0001510|GO:0010467|GO:0016070|GO:0006364|GO:0006396|GO:0034660|GO:0031167|GO:0009451|GO:0008173|GO:0008757|GO:0008170|GO:0008649|GO:0016072|GO:0000154|GO:0070475|GO:0071424 membrane|cellular process|metabolic process|binding|catalytic activity|methylation|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|intrinsic component of membrane|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|integral component of membrane|ribonucleoprotein complex biogenesis|methyltransferase activity|macromolecule modification|ribosome biogenesis|RNA methylation|gene expression|RNA metabolic process|rRNA processing|RNA processing|ncRNA metabolic process|rRNA methylation|RNA modification|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|N-methyltransferase activity|rRNA methyltransferase activity|rRNA metabolic process|rRNA modification|rRNA base methylation|rRNA (cytosine-N4-)-methyltransferase activity - - - - 11:28108248-28527041 29 33 47 506 593 450 0.217467689697883 0.224903147807396 0.31776405399289 3.39972664151952 3.64853332897213 3.16254879759827 0.253378297166056 3.40360292269664 -3.74769787407574 5.59372144324265e-40 3.27441097973659e-37 DOWN ENSG00000145743 FBXL17 F-box and leucine-rich repeat protein 17 [Source:HGNC Symbol;Acc:HGNC:13615] GO:0005488|GO:0005515 binding|protein binding - - - - 5:107859035-108382098 24 31 42 451 512 621 0.109168013099149 0.128154896090864 0.172246893158525 1.83806640688031 1.91084352807371 2.64732786331054 0.136523267449513 2.13207926608819 -3.96504232187149 7.97933346023713e-40 4.58105809849845e-37 DOWN ENSG00000176658 MYO1D myosin ID [Source:HGNC Symbol;Acc:HGNC:7598] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0043209|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0044297|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0019222|GO:0005903|GO:0043025|GO:0016323|GO:0006810|GO:0044853|GO:0043168|GO:0001882|GO:0031982|GO:0016817|GO:0043231|GO:0005737|GO:0032403|GO:0043005|GO:0048306|GO:0036477|GO:0016459|GO:0019904|GO:0005516|GO:0044092|GO:0005783|GO:0032589|GO:0070062|GO:0051649|GO:0008092|GO:0031256|GO:0050790|GO:0000166|GO:0031253|GO:0043086|GO:0019538|GO:0098857|GO:0031324|GO:0031323|GO:0005768|GO:0016192|GO:0032268|GO:0035639|GO:0030424|GO:0043412|GO:0031410|GO:0001883|GO:0003779|GO:0005790|GO:0016818|GO:0036211|GO:0032269|GO:0046907|GO:0032549|GO:0044304|GO:0030425|GO:0030673|GO:0051346|GO:0051015|GO:0006796|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:0045121|GO:0005856|GO:0015629|GO:0010923|GO:0016311|GO:0097440|GO:0005524|GO:0030554|GO:0016482|GO:0016197|GO:0006464|GO:0016462|GO:0010921|GO:0061502|GO:0006470|GO:0035304|GO:0017111|GO:0035305|GO:0035303|GO:0035308|GO:0016887|GO:0003774|GO:0000146|GO:0042623|GO:0030898 macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|myelin sheath|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell body|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|regulation of metabolic process|brush border|neuronal cell body|basolateral plasma membrane|transport|plasma membrane raft|anion binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|protein complex binding|neuron projection|calcium-dependent protein binding|somatodendritic compartment|myosin complex|protein domain specific binding|calmodulin binding|negative regulation of molecular function|endoplasmic reticulum|neuron projection membrane|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|leading edge membrane|regulation of catalytic activity|nucleotide binding|cell projection membrane|negative regulation of catalytic activity|protein metabolic process|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endosome|vesicle-mediated transport|regulation of cellular protein metabolic process|purine ribonucleoside triphosphate binding|axon|macromolecule modification|cytoplasmic vesicle|purine nucleoside binding|actin binding|smooth endoplasmic reticulum|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|negative regulation of cellular protein metabolic process|intracellular transport|ribonucleoside binding|main axon|dendrite|axolemma|negative regulation of hydrolase activity|actin filament binding|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|membrane raft|cytoskeleton|actin cytoskeleton|negative regulation of phosphatase activity|dephosphorylation|apical dendrite|ATP binding|adenyl nucleotide binding|cytosolic transport|endosomal transport|cellular protein modification process|pyrophosphatase activity|regulation of phosphatase activity|early endosome to recycling endosome transport|protein dephosphorylation|regulation of protein dephosphorylation|nucleoside-triphosphatase activity|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation|ATPase activity|motor activity|microfilament motor activity|ATPase activity, coupled|actin-dependent ATPase activity - - - - 17:32492522-32877177 31 21 66 801 882 751 0.164294586260318 0.101151102743563 0.315368092835515 3.80357861732639 3.83529486901957 3.73019186105133 0.193604593946465 3.78968844913243 -4.29089415797164 8.22383989556885e-40 4.6323493630625e-37 DOWN ENSG00000122966 CIT citron rho-interacting serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:1985] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0051726|GO:0007049|GO:0022402|GO:0007275|GO:0051302|GO:0043168|GO:0001882|GO:0016772|GO:0043169|GO:0005737|GO:0097110|GO:0045787|GO:0019904|GO:0007154|GO:0007165|GO:0000166|GO:0051781|GO:0051301|GO:0048869|GO:0019538|GO:0006996|GO:0032467|GO:0005829|GO:0090068|GO:0046872|GO:0035639|GO:1903047|GO:0043412|GO:0017124|GO:0001883|GO:0030165|GO:0036211|GO:0000278|GO:0032549|GO:0032465|GO:0010564|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0007067|GO:0007399|GO:0017076|GO:0030154|GO:0016773|GO:0000910|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0022008|GO:0007264|GO:0006464|GO:0006468|GO:0048699|GO:0004674 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|intracellular|protein binding|transferase activity|anatomical structure development|regulation of cell cycle|cell cycle|cell cycle process|multicellular organism development|regulation of cell division|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|cytoplasm|scaffold protein binding|positive regulation of cell cycle|protein domain specific binding|cell communication|signal transduction|nucleotide binding|positive regulation of cell division|cell division|cellular developmental process|protein metabolic process|organelle organization|positive regulation of cytokinesis|cytosol|positive regulation of cell cycle process|metal ion binding|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|SH3 domain binding|purine nucleoside binding|PDZ domain binding|protein modification process|mitotic cell cycle|ribonucleoside binding|regulation of cytokinesis|regulation of cell cycle process|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|mitotic nuclear division|nervous system development|purine nucleotide binding|cell differentiation|phosphotransferase activity, alcohol group as acceptor|cytokinesis|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|neurogenesis|small GTPase mediated signal transduction|cellular protein modification process|protein phosphorylation|generation of neurons|protein serine/threonine kinase activity - - - - 12:119685790-119877291 63 73 66 659 742 726 0.194366991410308 0.204684380514216 0.183584173721023 1.82164180592922 1.87824127860829 2.09915891419914 0.194211848548516 1.93301399957888 -3.3151489610715 1.05149834215624e-39 5.81322805680228e-37 DOWN ENSG00000196712 NF1 neurofibromin 1 [Source:HGNC Symbol;Acc:HGNC:7765] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0040013|GO:0042995|GO:0002683|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043473|GO:0007155|GO:0043227|GO:0044708|GO:0008289|GO:0071944|GO:1903828|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0030234|GO:0050793|GO:0005622|GO:0002682|GO:0007269|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0060341|GO:0008284|GO:0042127|GO:1903706|GO:0031210|GO:1900181|GO:0009898|GO:0050804|GO:0006935|GO:0045087|GO:0045595|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0009314|GO:0006810|GO:0035295|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0010632|GO:0045596|GO:0048513|GO:0050877|GO:0034641|GO:0043168|GO:0008047|GO:0043062|GO:0044281|GO:0032940|GO:0006952|GO:0030155|GO:0030900|GO:0005543|GO:0019637|GO:0031325|GO:0046483|GO:0033554|GO:0007632|GO:0007420|GO:0050806|GO:0010942|GO:0050803|GO:0061061|GO:0043231|GO:0043178|GO:0043169|GO:0010243|GO:0048144|GO:0048853|GO:0005737|GO:0007267|GO:0009611|GO:0060322|GO:0021987|GO:0007423|GO:0032880|GO:0009408|GO:0021764|GO:0006928|GO:0009887|GO:0042592|GO:0098562|GO:0043005|GO:0021915|GO:0031589|GO:0009966|GO:0050673|GO:0045184|GO:0048771|GO:0036477|GO:0048871|GO:0032387|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0007162|GO:0050776|GO:0001525|GO:0055086|GO:0008104|GO:0007154|GO:0044092|GO:0061535|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0001503|GO:0051649|GO:0045124|GO:0061351|GO:0009725|GO:0008219|GO:0051271|GO:0001505|GO:0007611|GO:0008285|GO:0001666|GO:0090317|GO:0021543|GO:0050790|GO:0051048|GO:1903531|GO:0030030|GO:0046929|GO:0061534|GO:0050805|GO:0034103|GO:0043086|GO:0048869|GO:0030029|GO:2000145|GO:0021537|GO:0009967|GO:0044249|GO:0009266|GO:0019538|GO:0023014|GO:0051589|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:2000146|GO:0048732|GO:0006996|GO:0072089|GO:0071774|GO:0046928|GO:0050768|GO:0016525|GO:0000165|GO:0006836|GO:0050679|GO:1902533|GO:0005730|GO:2001235|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0048485|GO:0010468|GO:0046850|GO:0090132|GO:0005096|GO:0042308|GO:0048167|GO:0007166|GO:0001654|GO:0051349|GO:0030424|GO:0001944|GO:0043412|GO:0072594|GO:0007010|GO:0030097|GO:0072358|GO:0007417|GO:0021782|GO:0051345|GO:0007612|GO:0001655|GO:0019693|GO:0048483|GO:0001894|GO:0030695|GO:2000178|GO:0021510|GO:0032386|GO:1901216|GO:0007405|GO:0070997|GO:0010721|GO:0051223|GO:0015031|GO:1901652|GO:0021761|GO:0000904|GO:0009790|GO:0001889|GO:0071417|GO:0001656|GO:0030334|GO:0031279|GO:0001935|GO:0010812|GO:0001667|GO:0051347|GO:0036211|GO:0032269|GO:0060840|GO:0070201|GO:0060537|GO:0007160|GO:0042060|GO:0048844|GO:0046907|GO:2000647|GO:0031235|GO:0072001|GO:0006811|GO:0001649|GO:0046849|GO:0048145|GO:0051046|GO:0035270|GO:0031981|GO:0045765|GO:0043434|GO:0030425|GO:0044344|GO:0034605|GO:0010810|GO:0051247|GO:0070848|GO:0050678|GO:0002764|GO:0050680|GO:1901214|GO:0030325|GO:0030036|GO:0030336|GO:0034613|GO:0032270|GO:0012501|GO:0060291|GO:0060429|GO:0006796|GO:1901342|GO:0035556|GO:1901137|GO:0044267|GO:0051174|GO:0010467|GO:0017038|GO:0032990|GO:0048854|GO:0007399|GO:0046903|GO:0071310|GO:0050890|GO:0097485|GO:1902532|GO:0010594|GO:0030198|GO:0048147|GO:0031281|GO:0031328|GO:0051246|GO:0030154|GO:0008429|GO:0048858|GO:0043068|GO:0007517|GO:1903827|GO:1902531|GO:2000177|GO:0072359|GO:0014047|GO:0032870|GO:0005634|GO:0009416|GO:0043067|GO:0032228|GO:0045638|GO:0006606|GO:0051960|GO:0045637|GO:0097190|GO:0072091|GO:0008366|GO:0008542|GO:0007422|GO:0048666|GO:0030182|GO:0002521|GO:0007411|GO:0002761|GO:1904589|GO:0060538|GO:0006820|GO:0015711|GO:0014044|GO:0033365|GO:0033157|GO:0009792|GO:0031401|GO:0008543|GO:0010001|GO:0048168|GO:0043065|GO:0051169|GO:0009259|GO:1901653|GO:0043408|GO:0043010|GO:1902692|GO:0043523|GO:0009117|GO:0046390|GO:0008306|GO:0097192|GO:0021897|GO:2001236|GO:0001953|GO:0043525|GO:0071363|GO:0014002|GO:0043087|GO:0043535|GO:0016310|GO:0006605|GO:0002768|GO:0038179|GO:2001238|GO:0061564|GO:0046942|GO:0016482|GO:0001936|GO:0002762|GO:0006886|GO:0048017|GO:0043547|GO:0007167|GO:0001952|GO:0045453|GO:0045761|GO:0030199|GO:0071375|GO:0043410|GO:0001937|GO:0006163|GO:0010631|GO:0048709|GO:0042981|GO:0007406|GO:0045762|GO:0042992|GO:0001938|GO:1900271|GO:0043409|GO:0048745|GO:0033673|GO:0032868|GO:0006865|GO:0051402|GO:0042306|GO:0042552|GO:0030099|GO:0051056|GO:1900180|GO:0014706|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0051058|GO:0050767|GO:0098597|GO:0048812|GO:0009165|GO:0097191|GO:0042991|GO:0014037|GO:0046717|GO:0043549|GO:0048708|GO:0006915|GO:0048592|GO:0033674|GO:0048011|GO:0048715|GO:0045686|GO:0015718|GO:1903533|GO:0048710|GO:0000186|GO:0048169|GO:0007265|GO:0002573|GO:0006913|GO:0046578|GO:0006164|GO:0030801|GO:0045859|GO:0048015|GO:0045860|GO:0006469|GO:0007409|GO:0048593|GO:1902043|GO:0006468|GO:0043407|GO:0048699|GO:0007519|GO:0014013|GO:0006835|GO:0015812|GO:0045685|GO:0014051|GO:0043405|GO:2001239|GO:0042325|GO:2001241|GO:0001932|GO:0032869|GO:0022011|GO:0042326|GO:0038093|GO:0042063|GO:0009187|GO:0043009|GO:0001934|GO:0042990|GO:0001933|GO:0043542|GO:0045670|GO:0048713|GO:0042327|GO:0045671|GO:0008625|GO:0034504|GO:0046822|GO:0046580|GO:0030802|GO:0007268|GO:0007169|GO:0009190|GO:1902041|GO:0048712|GO:0035021|GO:0048010|GO:0051170|GO:0046058|GO:0007270|GO:0030819|GO:0038095|GO:0009152|GO:0071901|GO:0016601|GO:0030817|GO:0030316|GO:0052652|GO:0030814|GO:0014065|GO:0071900|GO:0030816|GO:0035020|GO:0032147|GO:0008286|GO:0038127|GO:0043534|GO:0006171|GO:0007173|GO:0051932|GO:0035249 locomotion|developmental process|immune system process|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|negative regulation of locomotion|cell projection|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|pigmentation|cell adhesion|membrane-bounded organelle|single-organism behavior|lipid binding|cell periphery|negative regulation of cellular protein localization|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|regulation of developmental process|intracellular|regulation of immune system process|neurotransmitter secretion|immune system development|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|regulation of hemopoiesis|phosphatidylcholine binding|negative regulation of protein localization to nucleus|cytoplasmic side of plasma membrane|modulation of synaptic transmission|chemotaxis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|response to radiation|transport|tube development|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|negative regulation of cell differentiation|animal organ development|neurological system process|cellular nitrogen compound metabolic process|anion binding|enzyme activator activity|extracellular structure organization|small molecule metabolic process|secretion by cell|defense response|regulation of cell adhesion|forebrain development|phospholipid binding|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|visual behavior|brain development|positive regulation of synaptic transmission|positive regulation of cell death|regulation of synapse structure or activity|muscle structure development|intracellular membrane-bounded organelle|alcohol binding|cation binding|response to organonitrogen compound|fibroblast proliferation|forebrain morphogenesis|cytoplasm|cell-cell signaling|response to wounding|head development|cerebral cortex development|sensory organ development|regulation of protein localization|response to heat|amygdala development|movement of cell or subcellular component|organ morphogenesis|homeostatic process|cytoplasmic side of membrane|neuron projection|neural tube development|cell-substrate adhesion|regulation of signal transduction|epithelial cell proliferation|establishment of protein localization|tissue remodeling|somatodendritic compartment|multicellular organismal homeostasis|negative regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|negative regulation of cell adhesion|regulation of immune response|angiogenesis|nucleobase-containing small molecule metabolic process|protein localization|cell communication|negative regulation of molecular function|glutamate secretion, neurotransmission|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|ossification|establishment of localization in cell|regulation of bone resorption|neural precursor cell proliferation|response to hormone|cell death|negative regulation of cellular component movement|regulation of neurotransmitter levels|learning or memory|negative regulation of cell proliferation|response to hypoxia|negative regulation of intracellular protein transport|pallium development|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|cell projection organization|negative regulation of neurotransmitter secretion|gamma-aminobutyric acid secretion, neurotransmission|negative regulation of synaptic transmission|regulation of tissue remodeling|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|regulation of cell motility|telencephalon development|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of neurotransmitter transport|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|gland development|organelle organization|stem cell proliferation|response to fibroblast growth factor|regulation of neurotransmitter secretion|negative regulation of neurogenesis|negative regulation of angiogenesis|MAPK cascade|neurotransmitter transport|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|nucleolus|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|sympathetic nervous system development|regulation of gene expression|regulation of bone remodeling|epithelium migration|GTPase activator activity|negative regulation of protein import into nucleus|regulation of synaptic plasticity|cell surface receptor signaling pathway|eye development|positive regulation of lyase activity|axon|vasculature development|macromolecule modification|establishment of protein localization to organelle|cytoskeleton organization|hemopoiesis|cardiovascular system development|central nervous system development|glial cell development|positive regulation of hydrolase activity|learning|urogenital system development|ribose phosphate metabolic process|autonomic nervous system development|tissue homeostasis|GTPase regulator activity|negative regulation of neural precursor cell proliferation|spinal cord development|regulation of intracellular transport|positive regulation of neuron death|neuroblast proliferation|neuron death|negative regulation of cell development|regulation of protein transport|protein transport|response to peptide|limbic system development|cell morphogenesis involved in differentiation|embryo development|liver development|cellular response to organonitrogen compound|metanephros development|regulation of cell migration|regulation of cyclase activity|endothelial cell proliferation|negative regulation of cell-substrate adhesion|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|artery development|regulation of establishment of protein localization|muscle tissue development|cell-matrix adhesion|wound healing|artery morphogenesis|intracellular transport|negative regulation of stem cell proliferation|intrinsic component of the cytoplasmic side of the plasma membrane|renal system development|ion transport|osteoblast differentiation|bone remodeling|regulation of fibroblast proliferation|regulation of secretion|endocrine system development|nuclear lumen|regulation of angiogenesis|response to peptide hormone|dendrite|cellular response to fibroblast growth factor stimulus|cellular response to heat|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|response to growth factor|regulation of epithelial cell proliferation|immune response-regulating signaling pathway|negative regulation of epithelial cell proliferation|regulation of neuron death|adrenal gland development|actin cytoskeleton organization|negative regulation of cell migration|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|long-term synaptic potentiation|epithelium development|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|protein import|cell part morphogenesis|brain morphogenesis|nervous system development|secretion|cellular response to organic substance|cognition|neuron projection guidance|negative regulation of intracellular signal transduction|regulation of endothelial cell migration|extracellular matrix organization|negative regulation of fibroblast proliferation|positive regulation of cyclase activity|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cell differentiation|phosphatidylethanolamine binding|cell projection morphogenesis|positive regulation of programmed cell death|muscle organ development|regulation of cellular protein localization|regulation of intracellular signal transduction|regulation of neural precursor cell proliferation|circulatory system development|glutamate secretion|cellular response to hormone stimulus|nucleus|response to light stimulus|regulation of programmed cell death|regulation of synaptic transmission, GABAergic|negative regulation of myeloid cell differentiation|protein import into nucleus|regulation of nervous system development|regulation of myeloid cell differentiation|apoptotic signaling pathway|regulation of stem cell proliferation|axon ensheathment|visual learning|peripheral nervous system development|neuron development|neuron differentiation|leukocyte differentiation|axon guidance|regulation of myeloid leukocyte differentiation|regulation of protein import|skeletal muscle organ development|anion transport|organic anion transport|Schwann cell development|protein localization to organelle|regulation of intracellular protein transport|embryo development ending in birth or egg hatching|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|glial cell differentiation|regulation of neuronal synaptic plasticity|positive regulation of apoptotic process|nuclear transport|ribonucleotide metabolic process|cellular response to peptide|regulation of MAPK cascade|camera-type eye development|regulation of neuroblast proliferation|regulation of neuron apoptotic process|nucleotide metabolic process|ribose phosphate biosynthetic process|associative learning|extrinsic apoptotic signaling pathway in absence of ligand|forebrain astrocyte development|regulation of extrinsic apoptotic signaling pathway|negative regulation of cell-matrix adhesion|positive regulation of neuron apoptotic process|cellular response to growth factor stimulus|astrocyte development|regulation of GTPase activity|regulation of blood vessel endothelial cell migration|phosphorylation|protein targeting|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|positive regulation of extrinsic apoptotic signaling pathway|axon development|carboxylic acid transport|cytosolic transport|regulation of endothelial cell proliferation|negative regulation of myeloid leukocyte differentiation|intracellular protein transport|inositol lipid-mediated signaling|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|bone resorption|regulation of adenylate cyclase activity|collagen fibril organization|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|negative regulation of endothelial cell proliferation|purine nucleotide metabolic process|epithelial cell migration|oligodendrocyte differentiation|regulation of apoptotic process|negative regulation of neuroblast proliferation|positive regulation of adenylate cyclase activity|negative regulation of transcription factor import into nucleus|positive regulation of endothelial cell proliferation|regulation of long-term synaptic potentiation|negative regulation of MAPK cascade|smooth muscle tissue development|negative regulation of kinase activity|response to insulin|amino acid transport|neuron apoptotic process|regulation of protein import into nucleus|myelination|myeloid cell differentiation|regulation of small GTPase mediated signal transduction|regulation of protein localization to nucleus|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|regulation of neurogenesis|observational learning|neuron projection morphogenesis|nucleotide biosynthetic process|extrinsic apoptotic signaling pathway|transcription factor import into nucleus|Schwann cell differentiation|acid secretion|regulation of kinase activity|astrocyte differentiation|apoptotic process|eye morphogenesis|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|negative regulation of oligodendrocyte differentiation|negative regulation of glial cell differentiation|monocarboxylic acid transport|regulation of protein targeting|regulation of astrocyte differentiation|activation of MAPKK activity|regulation of long-term neuronal synaptic plasticity|Ras protein signal transduction|myeloid leukocyte differentiation|nucleocytoplasmic transport|regulation of Ras protein signal transduction|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|negative regulation of protein kinase activity|axonogenesis|camera-type eye morphogenesis|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|protein phosphorylation|negative regulation of MAP kinase activity|generation of neurons|skeletal muscle tissue development|regulation of gliogenesis|dicarboxylic acid transport|gamma-aminobutyric acid transport|regulation of glial cell differentiation|gamma-aminobutyric acid secretion|regulation of MAP kinase activity|regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of phosphorylation|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of protein phosphorylation|cellular response to insulin stimulus|myelination in peripheral nervous system|negative regulation of phosphorylation|Fc receptor signaling pathway|gliogenesis|cyclic nucleotide metabolic process|chordate embryonic development|positive regulation of protein phosphorylation|regulation of transcription factor import into nucleus|negative regulation of protein phosphorylation|endothelial cell migration|regulation of osteoclast differentiation|regulation of oligodendrocyte differentiation|positive regulation of phosphorylation|negative regulation of osteoclast differentiation|extrinsic apoptotic signaling pathway via death domain receptors|protein localization to nucleus|regulation of nucleocytoplasmic transport|negative regulation of Ras protein signal transduction|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|cyclic nucleotide biosynthetic process|regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of astrocyte differentiation|negative regulation of Rac protein signal transduction|vascular endothelial growth factor receptor signaling pathway|nuclear import|cAMP metabolic process|neuron-neuron synaptic transmission|positive regulation of cAMP biosynthetic process|Fc-epsilon receptor signaling pathway|purine ribonucleotide biosynthetic process|negative regulation of protein serine/threonine kinase activity|Rac protein signal transduction|regulation of cAMP biosynthetic process|osteoclast differentiation|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|phosphatidylinositol 3-kinase signaling|regulation of protein serine/threonine kinase activity|positive regulation of cAMP metabolic process|regulation of Rac protein signal transduction|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|blood vessel endothelial cell migration|cAMP biosynthetic process|epidermal growth factor receptor signaling pathway|synaptic transmission, GABAergic|synaptic transmission, glutamatergic K08052 neurofibromin 1[-] hsa04010|hsa04014 MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human) 17:31094927-31382116 140 181 277 1844 1999 2336 0.302747168823496 0.355722298339074 0.540065621313636 3.57281590278709 3.54676687775794 4.73427788283637 0.399511696158735 3.9512868877938 -3.30601295325453 1.22592677267617e-39 6.65433052208626e-37 DOWN ENSG00000198522 GPN1 GPN-loop GTPase 1 [Source:HGNC Symbol;Acc:HGNC:17030] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005737|GO:0000166|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0031981|GO:0005654|GO:0005739|GO:0017076|GO:0005634|GO:0032561|GO:0005525|GO:0019001|GO:0016462|GO:0017111|GO:0003924 cell|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|nucleoplasm|mitochondrion|purine nucleotide binding|nucleus|guanyl ribonucleotide binding|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|GTPase activity - - - - 2:27628247-27651508 93 76 129 962 1172 885 0.91026975625424 0.676052989900274 1.13838869355721 8.43646442853045 9.41203147193161 8.11819820137295 0.908237146570575 8.65556470061167 -3.25248699722886 3.0677586544006e-39 1.63544405122278e-36 DOWN ENSG00000122482 ZNF644 zinc finger protein 644 [Source:HGNC Symbol;Acc:HGNC:29222] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 1:90915298-91022272 66 30 60 988 1216 783 0.275012602345994 0.113608568707121 0.225413311230506 3.68862903360952 4.15730614725092 3.05774188099613 0.204678160761207 3.63455902061886 -4.15035125366647 3.29088976333221e-39 1.69390039645724e-36 DOWN ENSG00000180574 EIF2S3L Putative eukaryotic translation initiation factor 2 subunit 3-like protein [Source:UniProtKB/Swiss-Prot;Acc:Q2VIR3] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0016787|GO:0009058|GO:0005622|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0016817|GO:0022607|GO:0006413|GO:0000166|GO:0044249|GO:0022613|GO:0019538|GO:0034645|GO:0006518|GO:0003723|GO:0035639|GO:0001731|GO:0001883|GO:0016818|GO:0032549|GO:0022618|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0032561|GO:0043043|GO:0034622|GO:0006412|GO:0005525|GO:0008135|GO:0019001|GO:0016462|GO:0017111|GO:0003743|GO:0003924 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|hydrolase activity|biosynthetic process|intracellular|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|cellular component assembly|translational initiation|nucleotide binding|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|purine ribonucleoside triphosphate binding|formation of translation preinitiation complex|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|ribonucleoprotein complex assembly|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|guanyl ribonucleotide binding|peptide biosynthetic process|cellular macromolecular complex assembly|translation|GTP binding|translation factor activity, RNA binding|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|translation initiation factor activity|GTPase activity - - - - 12:10505602-10523135 34 43 40 492 498 490 0.642380785826765 0.738350537942804 0.681371616323398 8.32862008311163 7.71981603819094 8.67631015133685 0.687367646697656 8.24158209087981 -3.58376745711357 3.25226751154982e-39 1.69390039645724e-36 DOWN ENSG00000156639 ZFAND3 zinc finger, AN1-type domain 3 [Source:HGNC Symbol;Acc:HGNC:18019] GO:0005488|GO:0097159|GO:0043167|GO:0003676|GO:0043169|GO:0003677|GO:0046872|GO:0046914|GO:0008270 binding|organic cyclic compound binding|ion binding|nucleic acid binding|cation binding|DNA binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 6:37819499-38154624 73 60 145 1267 1219 1343 0.864810250969216 0.645995331559901 1.5487496098284 13.4484701438365 11.8486857470753 14.9108973715608 1.01985173078584 13.4026844208242 -3.7160906576429 4.2683681328361e-39 2.15979427521507e-36 DOWN ENSG00000011426 ANLN anillin actin binding protein [Source:HGNC Symbol;Acc:HGNC:14082] GO:0040011|GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0005488|GO:0050794|GO:0070938|GO:0043229|GO:0048870|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0005826|GO:0051726|GO:0007049|GO:0022402|GO:0005938|GO:0007275|GO:0048513|GO:0051302|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0006928|GO:0016477|GO:0008092|GO:0051301|GO:0048869|GO:0006996|GO:0090132|GO:0030864|GO:1903047|GO:0007010|GO:0030097|GO:0003779|GO:0044770|GO:0001667|GO:0000278|GO:0031981|GO:0007346|GO:0010564|GO:0005654|GO:0006461|GO:0070925|GO:0033043|GO:0007067|GO:0030154|GO:0005856|GO:0000910|GO:0005634|GO:0015629|GO:0034622|GO:0007088|GO:0000921|GO:0044772|GO:0043623|GO:0032185|GO:1901990|GO:0010631|GO:0002244|GO:1901987|GO:0030863|GO:0000281|GO:0010458|GO:0090521|GO:0007096 locomotion|developmental process|immune system process|cell|cellular process|binding|regulation of cellular process|contractile ring|intracellular organelle|cell motility|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|immune system development|protein binding|anatomical structure development|actomyosin contractile ring|regulation of cell cycle|cell cycle|cell cycle process|cell cortex|multicellular organism development|animal organ development|regulation of cell division|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|cell migration|cytoskeletal protein binding|cell division|cellular developmental process|organelle organization|epithelium migration|cortical actin cytoskeleton|mitotic cell cycle process|cytoskeleton organization|hemopoiesis|actin binding|cell cycle phase transition|ameboidal-type cell migration|mitotic cell cycle|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|protein complex assembly|organelle assembly|regulation of organelle organization|mitotic nuclear division|cell differentiation|cytoskeleton|cytokinesis|nucleus|actin cytoskeleton|cellular macromolecular complex assembly|regulation of mitotic nuclear division|septin ring assembly|mitotic cell cycle phase transition|cellular protein complex assembly|septin cytoskeleton organization|regulation of mitotic cell cycle phase transition|epithelial cell migration|hematopoietic progenitor cell differentiation|regulation of cell cycle phase transition|cortical cytoskeleton|mitotic cytokinesis|exit from mitosis|glomerular visceral epithelial cell migration|regulation of exit from mitosis - - - - 7:36389806-36453791 570 643 977 6025 6671 5336 4.24644404286711 4.35352982216952 6.56235086531043 40.2166172990694 40.776475430825 37.2559413257774 5.05410824344902 39.4163446852239 -2.96326552497866 6.73810568756716e-39 3.3526567866105e-36 DOWN ENSG00000186187 ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:18452] GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0003824|GO:0030672|GO:0008021|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0031982|GO:0043231|GO:0043169|GO:0030133|GO:0005737|GO:0012506|GO:0030658|GO:0019787|GO:0019538|GO:0005768|GO:0005829|GO:0046872|GO:0043412|GO:0030163|GO:0031410|GO:0004842|GO:0044265|GO:0005773|GO:0016023|GO:0036211|GO:0070382|GO:0006508|GO:0031988|GO:0030659|GO:0044267|GO:0044257|GO:0061630|GO:0010498|GO:0000323|GO:0051603|GO:0046914|GO:0006464|GO:0005764|GO:0019941|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0016567|GO:0000209|GO:0070936 synapse|cell|membrane|cellular process|metabolic process|cell junction|binding|catalytic activity|synaptic vesicle membrane|synaptic vesicle|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|ligase activity|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|vesicle|intracellular membrane-bounded organelle|cation binding|transport vesicle|cytoplasm|vesicle membrane|transport vesicle membrane|ubiquitin-like protein transferase activity|protein metabolic process|endosome|cytosol|metal ion binding|macromolecule modification|protein catabolic process|cytoplasmic vesicle|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|vacuole|cytoplasmic, membrane-bounded vesicle|protein modification process|exocytic vesicle|proteolysis|membrane-bounded vesicle|cytoplasmic vesicle membrane|cellular protein metabolic process|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|lytic vacuole|proteolysis involved in cellular protein catabolic process|transition metal ion binding|cellular protein modification process|lysosome|modification-dependent protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination|protein K48-linked ubiquitination - - - - 16:74999030-75110994 79 101 135 917 1080 1343 0.261680327147093 0.304052818292854 0.40317505971989 2.72153061273707 2.93520024549275 4.16918605504984 0.322969401719946 3.27530563775989 -3.3421601443032 1.22578171133287e-38 5.90233664679542e-36 DOWN ENSG00000243156 MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 [Source:HGNC Symbol;Acc:HGNC:24694] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0048037|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0006810|GO:0043168|GO:0032940|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0016705|GO:0004497|GO:0008092|GO:0050662|GO:0000166|GO:0030029|GO:0006996|GO:0055114|GO:0016192|GO:0046872|GO:0007010|GO:0050660|GO:0016709|GO:0003779|GO:0006887|GO:0031981|GO:0005654|GO:0030036|GO:0046903|GO:0051020|GO:0005856|GO:0005634|GO:0043241|GO:0071949|GO:0031267|GO:0046914|GO:0007015|GO:0017016|GO:0043624|GO:0008270|GO:0008154|GO:0017137|GO:0030042|GO:0051261 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|cofactor binding|cell periphery|intracellular|protein binding|plasma membrane|transport|anion binding|secretion by cell|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|cytoskeletal protein binding|coenzyme binding|nucleotide binding|actin filament-based process|organelle organization|oxidation-reduction process|vesicle-mediated transport|metal ion binding|cytoskeleton organization|flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|actin binding|exocytosis|nuclear lumen|nucleoplasm|actin cytoskeleton organization|secretion|GTPase binding|cytoskeleton|nucleus|protein complex disassembly|FAD binding|small GTPase binding|transition metal ion binding|actin filament organization|Ras GTPase binding|cellular protein complex disassembly|zinc ion binding|actin polymerization or depolymerization|Rab GTPase binding|actin filament depolymerization|protein depolymerization - - - - 22:17787649-18024559 44 38 69 640 740 569 0.100096780459801 0.078565558596663 0.141525228830084 1.30450888228987 1.38123907191455 1.21313802477 0.106729189295516 1.29962865965814 -3.60607276676273 1.22050378413458e-38 5.90233664679542e-36 DOWN ENSG00000133863 TEX15 testis expressed 15 [Source:HGNC Symbol;Acc:HGNC:11738] GO:0032502|GO:0000003|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0016043|GO:0032504|GO:0048856|GO:0048609|GO:0019222|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0046483|GO:0033554|GO:0022607|GO:0048608|GO:0032880|GO:0042592|GO:0007548|GO:0070192|GO:0048871|GO:0006139|GO:0008104|GO:0007276|GO:0007126|GO:0009566|GO:0007059|GO:0048806|GO:0031323|GO:0006996|GO:0051276|GO:0048232|GO:0000725|GO:0046661|GO:0061458|GO:0030539|GO:0001894|GO:0007129|GO:0007130|GO:0006302|GO:0048872|GO:0007140|GO:0007127|GO:2001020|GO:0045132|GO:0006259|GO:0034613|GO:0006282|GO:0006974|GO:0007283|GO:0000724|GO:0033365|GO:0048873|GO:2000779|GO:0070193|GO:0045143|GO:0000018|GO:0006310|GO:0010569|GO:0034502 developmental process|reproduction|cellular process|reproductive process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|cellular component organization|multicellular organism reproduction|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|reproductive structure development|regulation of protein localization|homeostatic process|sex differentiation|chromosome organization involved in meiotic cell cycle|multicellular organismal homeostasis|nucleobase-containing compound metabolic process|protein localization|gamete generation|meiotic nuclear division|fertilization|chromosome segregation|genitalia development|regulation of cellular metabolic process|organelle organization|chromosome organization|male gamete generation|recombinational repair|male sex differentiation|reproductive system development|male genitalia development|tissue homeostasis|synapsis|synaptonemal complex assembly|double-strand break repair|homeostasis of number of cells|male meiosis|meiosis I|regulation of response to DNA damage stimulus|meiotic chromosome segregation|DNA metabolic process|cellular protein localization|regulation of DNA repair|cellular response to DNA damage stimulus|spermatogenesis|double-strand break repair via homologous recombination|protein localization to organelle|homeostasis of number of cells within a tissue|regulation of double-strand break repair|synaptonemal complex organization|homologous chromosome segregation|regulation of DNA recombination|DNA recombination|regulation of double-strand break repair via homologous recombination|protein localization to chromosome - - - - 8:30831544-30890606 32 34 30 432 459 426 0.186473888807898 0.180061641872342 0.157613873593185 2.25550957007859 2.19453937178754 2.32648927987709 0.174716468091142 2.25884607391441 -3.69249846096033 1.4492655259346e-38 6.86767825575421e-36 DOWN ENSG00000109452 INPP4B inositol polyphosphate-4-phosphatase type II B [Source:HGNC Symbol;Acc:HGNC:6075] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0044255|GO:0043647|GO:0016788|GO:0044281|GO:0019637|GO:0005737|GO:0007154|GO:0006629|GO:0007165|GO:0016021|GO:0044249|GO:0005829|GO:0008654|GO:0046486|GO:0006066|GO:0006796|GO:0008610|GO:0042578|GO:0006644|GO:0016311|GO:0046474|GO:0016791|GO:0006650|GO:0046488|GO:0006661|GO:0052866|GO:0036092|GO:0034593|GO:0016316|GO:0034597 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|cellular lipid metabolic process|inositol phosphate metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|cytoplasm|cell communication|lipid metabolic process|signal transduction|integral component of membrane|cellular biosynthetic process|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|alcohol metabolic process|phosphate-containing compound metabolic process|lipid biosynthetic process|phosphoric ester hydrolase activity|phospholipid metabolic process|dephosphorylation|glycerophospholipid biosynthetic process|phosphatase activity|glycerophospholipid metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|phosphatidylinositol phosphate phosphatase activity|phosphatidylinositol-3-phosphate biosynthetic process|phosphatidylinositol bisphosphate phosphatase activity|phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity K01109 inositol polyphosphate-4-phosphatase[3.1.3.66] hsa01100|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 4:142023160-142847432 59 60 60 633 615 668 0.242882259577139 0.224479900177162 0.222697804309438 2.33479026704111 2.07725559022926 2.57722450885162 0.230019988021246 2.32975678870733 -3.34034821742279 2.57384663227474e-38 1.20061902124891e-35 DOWN ENSG00000084676 NCOA1 nuclear receptor coactivator 1 [Source:HGNC Symbol;Acc:HGNC:7668] GO:0032502|GO:0032991|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0042698|GO:0019953|GO:0044237|GO:0003006|GO:0023051|GO:0000989|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0032504|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0047485|GO:0007618|GO:0044255|GO:0001890|GO:0045595|GO:0003712|GO:0006725|GO:0048468|GO:0060713|GO:0006810|GO:0021766|GO:1901360|GO:0010941|GO:0006082|GO:0045924|GO:0009991|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0044281|GO:0030902|GO:0030900|GO:0031325|GO:0046483|GO:0007420|GO:0010942|GO:0044849|GO:0045597|GO:0043231|GO:2001023|GO:0048608|GO:0019899|GO:0016746|GO:0021854|GO:0005737|GO:0031668|GO:0060322|GO:0021987|GO:0060669|GO:0001076|GO:0032403|GO:0043005|GO:0009966|GO:0046983|GO:0048598|GO:0048568|GO:0007548|GO:0003682|GO:0042493|GO:0010646|GO:0006139|GO:0001892|GO:0000790|GO:0008406|GO:0007154|GO:0022037|GO:0006629|GO:0007165|GO:0008134|GO:0009725|GO:0008219|GO:0021543|GO:0021549|GO:0048869|GO:0021537|GO:0044249|GO:0010876|GO:0019538|GO:0010033|GO:0031323|GO:0021536|GO:2001038|GO:0048732|GO:0050878|GO:0060711|GO:0006996|GO:0007584|GO:0003713|GO:0051276|GO:0016922|GO:0003677|GO:0030879|GO:0010468|GO:0034645|GO:0008584|GO:0033993|GO:0043412|GO:0046661|GO:0061458|GO:0007589|GO:0001104|GO:0007417|GO:0010720|GO:0051427|GO:1901522|GO:0051252|GO:0006325|GO:0042974|GO:0021761|GO:0009790|GO:0016573|GO:0010628|GO:0036211|GO:0031670|GO:0006811|GO:0031981|GO:0050769|GO:0045925|GO:0006869|GO:0005654|GO:0016747|GO:0005694|GO:0000228|GO:0002155|GO:0007595|GO:0007617|GO:1904017|GO:0008202|GO:0012501|GO:0014070|GO:0032526|GO:0044267|GO:0010467|GO:0007399|GO:0046903|GO:0071310|GO:0031328|GO:0035690|GO:0009059|GO:0030154|GO:0009755|GO:0008206|GO:0043068|GO:0031669|GO:0001191|GO:0016070|GO:0031667|GO:0032870|GO:0010557|GO:0005634|GO:0043067|GO:0048545|GO:0097305|GO:0051960|GO:0030522|GO:0046546|GO:0030182|GO:0043401|GO:0002154|GO:0000975|GO:0045893|GO:0006820|GO:0015711|GO:0009792|GO:0045990|GO:0043065|GO:0032570|GO:0032774|GO:0015721|GO:0060180|GO:2001141|GO:0035257|GO:0043967|GO:0043627|GO:0071383|GO:0071407|GO:0060179|GO:0030518|GO:0046942|GO:0016407|GO:0001105|GO:0046965|GO:0030374|GO:0016410|GO:0032355|GO:0042981|GO:0019752|GO:0016568|GO:0022008|GO:0006464|GO:0050767|GO:0071396|GO:0006351|GO:0006915|GO:0006355|GO:0045666|GO:0015718|GO:0045944|GO:0006366|GO:0035258|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0001190|GO:0018193|GO:0000435|GO:0030521|GO:0008080|GO:0043009|GO:0032787|GO:0045664|GO:0050681|GO:0001012|GO:0001701|GO:0030331|GO:0033142|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402 developmental process|macromolecular complex|reproduction|behavior|signaling|cell|rhythmic process|cellular process|reproductive process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ovulation cycle|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|regulation of developmental process|intracellular|protein binding|transferase activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|protein N-terminus binding|mating|cellular lipid metabolic process|placenta development|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|labyrinthine layer morphogenesis|transport|hippocampus development|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|regulation of female receptivity|response to extracellular stimulus|multicellular organism development|histone modification|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|hindbrain development|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|positive regulation of cell death|estrous cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|regulation of response to drug|reproductive structure development|enzyme binding|transferase activity, transferring acyl groups|hypothalamus development|cytoplasm|cellular response to extracellular stimulus|head development|cerebral cortex development|embryonic placenta morphogenesis|transcription factor activity, RNA polymerase II transcription factor binding|protein complex binding|neuron projection|regulation of signal transduction|protein dimerization activity|embryonic morphogenesis|embryonic organ development|sex differentiation|chromatin binding|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|nuclear chromatin|gonad development|cell communication|metencephalon development|lipid metabolic process|signal transduction|transcription factor binding|response to hormone|cell death|pallium development|cerebellum development|cellular developmental process|telencephalon development|cellular biosynthetic process|lipid localization|protein metabolic process|response to organic substance|regulation of cellular metabolic process|diencephalon development|regulation of cellular response to drug|gland development|regulation of body fluid levels|labyrinthine layer development|organelle organization|response to nutrient|transcription coactivator activity|chromosome organization|ligand-dependent nuclear receptor binding|DNA binding|mammary gland development|regulation of gene expression|cellular macromolecule biosynthetic process|male gonad development|response to lipid|macromolecule modification|male sex differentiation|reproductive system development|body fluid secretion|RNA polymerase II transcription cofactor activity|central nervous system development|positive regulation of cell development|hormone receptor binding|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|regulation of RNA metabolic process|chromatin organization|retinoic acid receptor binding|limbic system development|embryo development|histone acetylation|positive regulation of gene expression|protein modification process|cellular response to nutrient|ion transport|nuclear lumen|positive regulation of neurogenesis|positive regulation of female receptivity|lipid transport|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|chromosome|nuclear chromosome|regulation of thyroid hormone mediated signaling pathway|lactation|mating behavior|cellular response to Thyroglobulin triiodothyronine|steroid metabolic process|programmed cell death|response to organic cyclic compound|response to retinoic acid|cellular protein metabolic process|gene expression|nervous system development|secretion|cellular response to organic substance|positive regulation of cellular biosynthetic process|cellular response to drug|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|bile acid metabolic process|positive regulation of programmed cell death|cellular response to nutrient levels|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|response to nutrient levels|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|response to steroid hormone|response to alcohol|regulation of nervous system development|intracellular receptor signaling pathway|development of primary male sexual characteristics|neuron differentiation|steroid hormone mediated signaling pathway|thyroid hormone mediated signaling pathway|regulatory region DNA binding|positive regulation of transcription, DNA-templated|anion transport|organic anion transport|embryo development ending in birth or egg hatching|carbon catabolite regulation of transcription|positive regulation of apoptotic process|response to progesterone|RNA biosynthetic process|bile acid and bile salt transport|female mating behavior|regulation of RNA biosynthetic process|nuclear hormone receptor binding|histone H4 acetylation|response to estrogen|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|male mating behavior|intracellular steroid hormone receptor signaling pathway|carboxylic acid transport|acetyltransferase activity|RNA polymerase II transcription coactivator activity|retinoid X receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|N-acyltransferase activity|response to estradiol|regulation of apoptotic process|carboxylic acid metabolic process|chromatin modification|neurogenesis|cellular protein modification process|regulation of neurogenesis|cellular response to lipid|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|monocarboxylic acid transport|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcriptional activator activity, RNA polymerase II transcription factor binding|peptidyl-amino acid modification|positive regulation of transcription from RNA polymerase II promoter by galactose|androgen receptor signaling pathway|N-acetyltransferase activity|chordate embryonic development|monocarboxylic acid metabolic process|regulation of neuron differentiation|androgen receptor binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|estrogen receptor binding|progesterone receptor binding|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity K09101 nuclear receptor coactivator 1[2.3.1.48] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) 2:24491914-24770702 30 39 46 488 473 469 0.16343755001493 0.193101910485334 0.225949140749775 2.3820725647522 2.11429835891993 2.39463131572873 0.194162867083346 2.29700074646695 -3.56441210329541 2.73644118006743e-38 1.25682638445743e-35 DOWN ENSG00000172340 SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit [Source:HGNC Symbol;Acc:HGNC:11450] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0016874|GO:0005622|GO:0005886|GO:0006082|GO:0043168|GO:0015980|GO:0044281|GO:0001882|GO:0043231|GO:0005737|GO:0051186|GO:0006099|GO:0000166|GO:0006091|GO:0006790|GO:0055114|GO:0035639|GO:0006637|GO:0005815|GO:0001883|GO:0032549|GO:0016878|GO:0005759|GO:0005739|GO:0017076|GO:0045333|GO:0005856|GO:0005634|GO:0006104|GO:0032561|GO:0009060|GO:0005524|GO:0030554|GO:0015630|GO:0019752|GO:0005525|GO:0019001|GO:0072350|GO:0004776|GO:0006101 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|ligase activity|intracellular|plasma membrane|organic acid metabolic process|anion binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|nucleoside binding|intracellular membrane-bounded organelle|cytoplasm|cofactor metabolic process|tricarboxylic acid cycle|nucleotide binding|generation of precursor metabolites and energy|sulfur compound metabolic process|oxidation-reduction process|purine ribonucleoside triphosphate binding|acyl-CoA metabolic process|microtubule organizing center|purine nucleoside binding|ribonucleoside binding|acid-thiol ligase activity|mitochondrial matrix|mitochondrion|purine nucleotide binding|cellular respiration|cytoskeleton|nucleus|succinyl-CoA metabolic process|guanyl ribonucleotide binding|aerobic respiration|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|carboxylic acid metabolic process|GTP binding|guanyl nucleotide binding|tricarboxylic acid metabolic process|succinate-CoA ligase (GDP-forming) activity|citrate metabolic process K01900 succinyl-CoA synthetase beta subunit[6.2.1.5] hsa01100|hsa01200|hsa00640|hsa00020 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human)|Citrate cycle (TCA cycle) - Homo sapiens (human) 3:67360460-67654614 111 98 152 966 1081 1064 2.37716921661073 1.90740405805292 2.93490672421602 18.5358316183521 18.9946304783779 21.3554096858743 2.40649333295989 19.6286239275348 -3.02795470411708 3.09151039884317e-38 1.39839320374339e-35 DOWN ENSG00000091490 SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) [Source:HGNC Symbol;Acc:HGNC:29108] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0043231|GO:0016021|GO:0031981|GO:0005654|GO:0005634 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|intracellular membrane-bounded organelle|integral component of membrane|nuclear lumen|nucleoplasm|nucleus - - - - 4:25747427-25863760 169 168 271 1620 1744 1944 0.926205574982996 0.836775916114021 1.33907323365694 7.95487091032942 7.84214470076027 9.98494129930472 1.03401824158465 8.59398563679814 -3.05506572881055 3.36602882582451e-38 1.49984215770395e-35 DOWN ENSG00000164190 NIPBL Nipped-B homolog (Drosophila) [Source:HGNC Symbol;Acc:HGNC:28862] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0009628|GO:0044237|GO:0051641|GO:0003006|GO:0009653|GO:0000785|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0007507|GO:0047485|GO:0007049|GO:0040018|GO:0048565|GO:0032116|GO:0035239|GO:0006725|GO:0001822|GO:0008022|GO:0009314|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0061038|GO:0007275|GO:0061010|GO:0016570|GO:0048513|GO:0050877|GO:0060065|GO:0060325|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0007420|GO:0043231|GO:0048608|GO:0019899|GO:0035112|GO:0060322|GO:0007423|GO:0009887|GO:0032403|GO:0035264|GO:0048598|GO:0048568|GO:0007548|GO:0009890|GO:0048639|GO:0003682|GO:0019904|GO:0006139|GO:0010171|GO:0008104|GO:0045778|GO:0030278|GO:0003151|GO:0070062|GO:0048638|GO:0001503|GO:0060323|GO:0040014|GO:0007059|GO:0060324|GO:0048869|GO:0048806|GO:0042634|GO:0044249|GO:0019827|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0048705|GO:0000819|GO:0010468|GO:0034645|GO:0055123|GO:0001654|GO:1903047|GO:0043412|GO:0061458|GO:0072358|GO:0007417|GO:0001655|GO:0010629|GO:0043583|GO:0070087|GO:0031056|GO:0051252|GO:0006325|GO:0003007|GO:0009790|GO:0031058|GO:0001656|GO:0010628|GO:0036211|GO:0000278|GO:0072001|GO:0007600|GO:0035261|GO:0031981|GO:0007062|GO:0071478|GO:0042826|GO:0051247|GO:0005654|GO:0005694|GO:0034613|GO:0032270|GO:0010212|GO:0033043|GO:0035108|GO:0044267|GO:0007067|GO:0010467|GO:0048562|GO:0007399|GO:0048701|GO:0050890|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0001501|GO:0060173|GO:0048566|GO:0048546|GO:0016070|GO:0072359|GO:0036033|GO:0048703|GO:0010557|GO:0016575|GO:0005634|GO:0006974|GO:0045995|GO:0042633|GO:0010638|GO:2001252|GO:0031063|GO:0048706|GO:0045893|GO:0045444|GO:0009792|GO:0031401|GO:0050954|GO:0045892|GO:0032774|GO:0031065|GO:2001141|GO:0007064|GO:0033044|GO:1902679|GO:0048557|GO:0042471|GO:0000070|GO:0035136|GO:0016568|GO:0048704|GO:0071479|GO:0010165|GO:0006464|GO:0030326|GO:0034088|GO:0006351|GO:0006355|GO:0048592|GO:0035115|GO:0045944|GO:0006366|GO:1903507|GO:0090312|GO:0007605|GO:0006357|GO:1903506|GO:0090311|GO:0043009|GO:0000122|GO:0071481|GO:0006476 developmental process|growth|macromolecular complex|reproduction|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|developmental process involved in reproduction|anatomical structure morphogenesis|chromatin|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|heart development|protein N-terminus binding|cell cycle|positive regulation of multicellular organism growth|digestive tract development|SMC loading complex|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|protein C-terminus binding|response to radiation|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|uterus morphogenesis|multicellular organism development|gall bladder development|histone modification|animal organ development|neurological system process|uterus development|face morphogenesis|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|brain development|intracellular membrane-bounded organelle|reproductive structure development|enzyme binding|genitalia morphogenesis|head development|sensory organ development|organ morphogenesis|protein complex binding|multicellular organism growth|embryonic morphogenesis|embryonic organ development|sex differentiation|negative regulation of biosynthetic process|positive regulation of developmental growth|chromatin binding|protein domain specific binding|nucleobase-containing compound metabolic process|body morphogenesis|protein localization|positive regulation of ossification|regulation of ossification|outflow tract morphogenesis|extracellular exosome|regulation of developmental growth|ossification|head morphogenesis|regulation of multicellular organism growth|chromosome segregation|face development|cellular developmental process|genitalia development|regulation of hair cycle|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|skeletal system morphogenesis|sister chromatid segregation|regulation of gene expression|cellular macromolecule biosynthetic process|digestive system development|eye development|mitotic cell cycle process|macromolecule modification|reproductive system development|cardiovascular system development|central nervous system development|urogenital system development|negative regulation of gene expression|ear development|chromo shadow domain binding|regulation of histone modification|regulation of RNA metabolic process|chromatin organization|heart morphogenesis|embryo development|positive regulation of histone modification|metanephros development|positive regulation of gene expression|protein modification process|mitotic cell cycle|renal system development|sensory perception|external genitalia morphogenesis|nuclear lumen|sister chromatid cohesion|cellular response to radiation|histone deacetylase binding|positive regulation of protein metabolic process|nucleoplasm|chromosome|cellular protein localization|positive regulation of cellular protein metabolic process|response to ionizing radiation|regulation of organelle organization|limb morphogenesis|cellular protein metabolic process|mitotic nuclear division|gene expression|embryonic organ morphogenesis|nervous system development|embryonic cranial skeleton morphogenesis|cognition|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|limb development|embryonic digestive tract development|digestive tract morphogenesis|RNA metabolic process|circulatory system development|mediator complex binding|embryonic viscerocranium morphogenesis|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|cellular response to DNA damage stimulus|regulation of embryonic development|hair cycle|positive regulation of organelle organization|positive regulation of chromosome organization|regulation of histone deacetylation|embryonic skeletal system development|positive regulation of transcription, DNA-templated|fat cell differentiation|embryo development ending in birth or egg hatching|positive regulation of protein modification process|sensory perception of mechanical stimulus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|positive regulation of histone deacetylation|regulation of RNA biosynthetic process|mitotic sister chromatid cohesion|regulation of chromosome organization|negative regulation of RNA biosynthetic process|embryonic digestive tract morphogenesis|ear morphogenesis|mitotic sister chromatid segregation|forelimb morphogenesis|chromatin modification|embryonic skeletal system morphogenesis|cellular response to ionizing radiation|response to X-ray|cellular protein modification process|embryonic limb morphogenesis|maintenance of mitotic sister chromatid cohesion|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|embryonic forelimb morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|positive regulation of protein deacetylation|sensory perception of sound|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|regulation of protein deacetylation|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|cellular response to X-ray|protein deacetylation - - - - 5:36876759-37066413 285 295 341 1975 2274 2069 1.2780541539233 1.20228125637019 1.37870853111909 7.93539902089575 8.3668581593041 8.6954744055786 1.28634798047086 8.33257719525948 -2.69548180726491 5.12255267044674e-38 2.24895128563996e-35 DOWN ENSG00000106804 C5 complement component 5 [Source:HGNC Symbol;Acc:HGNC:1331] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0019835|GO:0051716|GO:0040013|GO:0002683|GO:0009892|GO:0048523|GO:0048521|GO:0050794|GO:0040012|GO:0051050|GO:0006950|GO:0071704|GO:0050900|GO:0009056|GO:0006955|GO:0044237|GO:0051641|GO:0050795|GO:0006914|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0031224|GO:0005615|GO:0030234|GO:0002684|GO:0050793|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0060341|GO:0002250|GO:0004857|GO:0006935|GO:0045087|GO:0006959|GO:0002685|GO:0006810|GO:0001568|GO:0098797|GO:0007275|GO:0005102|GO:0032940|GO:0006952|GO:0031982|GO:0031325|GO:0033554|GO:0001817|GO:0005887|GO:0001816|GO:0009611|GO:0050920|GO:0032880|GO:0051222|GO:0006928|GO:0009966|GO:0045184|GO:0006956|GO:0001819|GO:0046930|GO:0010646|GO:0031226|GO:0043085|GO:0050776|GO:0001525|GO:0008104|GO:0007154|GO:0044092|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0000422|GO:0002686|GO:0070062|GO:0050922|GO:0051271|GO:0016236|GO:0030595|GO:0051047|GO:0050790|GO:0043086|GO:0016021|GO:2000145|GO:0009967|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:2000146|GO:0002443|GO:0006996|GO:0000165|GO:1902533|GO:0032268|GO:0010574|GO:0007186|GO:0010468|GO:0048246|GO:0005126|GO:1903008|GO:0002688|GO:0007166|GO:0000423|GO:0001944|GO:0043412|GO:0006958|GO:0072358|GO:0050727|GO:0032642|GO:0030414|GO:0007005|GO:0051223|GO:0051604|GO:0015031|GO:0005125|GO:0009790|GO:0030334|GO:0005579|GO:0051347|GO:0036211|GO:0010575|GO:0032269|GO:0070201|GO:0006954|GO:0050714|GO:0032602|GO:0050715|GO:0045766|GO:0051046|GO:0006957|GO:0060326|GO:0045765|GO:0030449|GO:0009306|GO:0051247|GO:0051346|GO:0006508|GO:0001664|GO:0030336|GO:0002460|GO:0050663|GO:0032270|GO:0006796|GO:1901342|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0046903|GO:0051246|GO:0050707|GO:1902531|GO:0072359|GO:0002455|GO:0002689|GO:0002920|GO:0032722|GO:0010573|GO:0090197|GO:0004866|GO:0010466|GO:0002673|GO:0009792|GO:0031401|GO:0043408|GO:0016485|GO:0042379|GO:0030162|GO:0050708|GO:0016310|GO:0002526|GO:0052547|GO:0090195|GO:0010760|GO:0008009|GO:0043410|GO:0010758|GO:0045861|GO:0019724|GO:0006464|GO:0098779|GO:0043549|GO:0033674|GO:0016064|GO:0045859|GO:0045860|GO:0043406|GO:0006468|GO:0043405|GO:0042325|GO:0070613|GO:0001932|GO:0010951|GO:0043009|GO:0001934|GO:0042327|GO:0052548|GO:0000187|GO:0071902|GO:0071900|GO:0001701|GO:0032147 locomotion|developmental process|macromolecular complex|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cytolysis|cellular response to stimulus|negative regulation of locomotion|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|negative regulation of behavior|regulation of cellular process|regulation of locomotion|positive regulation of transport|response to stress|organic substance metabolic process|leukocyte migration|catabolic process|immune response|cellular metabolic process|cellular localization|regulation of behavior|autophagy|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|extracellular space|enzyme regulator activity|positive regulation of immune system process|regulation of developmental process|regulation of immune system process|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|adaptive immune response|enzyme inhibitor activity|chemotaxis|innate immune response|humoral immune response|regulation of leukocyte migration|transport|blood vessel development|plasma membrane protein complex|multicellular organism development|receptor binding|secretion by cell|defense response|vesicle|positive regulation of cellular metabolic process|cellular response to stress|regulation of cytokine production|integral component of plasma membrane|cytokine production|response to wounding|regulation of chemotaxis|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|regulation of signal transduction|establishment of protein localization|complement activation|positive regulation of cytokine production|pore complex|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|regulation of immune response|angiogenesis|protein localization|cell communication|negative regulation of molecular function|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|mitophagy|negative regulation of leukocyte migration|extracellular exosome|negative regulation of chemotaxis|negative regulation of cellular component movement|macroautophagy|leukocyte chemotaxis|positive regulation of secretion|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|leukocyte mediated immunity|organelle organization|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of vascular endothelial growth factor production|G-protein coupled receptor signaling pathway|regulation of gene expression|macrophage chemotaxis|cytokine receptor binding|organelle disassembly|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|macromitophagy|vasculature development|macromolecule modification|complement activation, classical pathway|cardiovascular system development|regulation of inflammatory response|regulation of chemokine production|peptidase inhibitor activity|mitochondrion organization|regulation of protein transport|protein maturation|protein transport|cytokine activity|embryo development|regulation of cell migration|membrane attack complex|positive regulation of transferase activity|protein modification process|positive regulation of vascular endothelial growth factor production|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|inflammatory response|positive regulation of protein secretion|chemokine production|positive regulation of cytokine secretion|positive regulation of angiogenesis|regulation of secretion|complement activation, alternative pathway|cell chemotaxis|regulation of angiogenesis|regulation of complement activation|protein secretion|positive regulation of protein metabolic process|negative regulation of hydrolase activity|proteolysis|G-protein coupled receptor binding|negative regulation of cell migration|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|cytokine secretion|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|secretion|regulation of protein metabolic process|regulation of cytokine secretion|regulation of intracellular signal transduction|circulatory system development|humoral immune response mediated by circulating immunoglobulin|negative regulation of leukocyte chemotaxis|regulation of humoral immune response|positive regulation of chemokine production|vascular endothelial growth factor production|positive regulation of chemokine secretion|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of acute inflammatory response|embryo development ending in birth or egg hatching|positive regulation of protein modification process|regulation of MAPK cascade|protein processing|chemokine receptor binding|regulation of proteolysis|regulation of protein secretion|phosphorylation|acute inflammatory response|regulation of peptidase activity|chemokine secretion|negative regulation of macrophage chemotaxis|chemokine activity|positive regulation of MAPK cascade|regulation of macrophage chemotaxis|negative regulation of proteolysis|B cell mediated immunity|cellular protein modification process|mitophagy in response to mitochondrial depolarization|regulation of kinase activity|positive regulation of kinase activity|immunoglobulin mediated immune response|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein processing|regulation of protein phosphorylation|negative regulation of endopeptidase activity|chordate embryonic development|positive regulation of protein phosphorylation|positive regulation of phosphorylation|regulation of endopeptidase activity|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|in utero embryonic development|activation of protein kinase activity K03994 complement component 5[-] hsa05168|hsa05322|hsa04610|hsa05133|hsa05150|hsa05020 Herpes simplex infection - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human)|Complement and coagulation cascades - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Staphylococcus aureus infection - Homo sapiens (human)|Prion diseases - Homo sapiens (human) 9:120952335-121050276 13 13 13 250 279 256 0.13619215770151 0.123780413460571 0.12279047715942 2.34666768453974 2.39820289309276 2.51351693116231 0.127587682773834 2.4194625029316 -4.24512561619612 8.78407011507976e-38 3.80057433645784e-35 DOWN ENSG00000157450 RNF111 ring finger protein 111 [Source:HGNC Symbol;Acc:HGNC:17384] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0006281|GO:0032182|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0090287|GO:0043231|GO:0046332|GO:0043169|GO:0005737|GO:0007389|GO:0071559|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0019787|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0005730|GO:0032268|GO:0010468|GO:0034645|GO:0046872|GO:0007166|GO:0043412|GO:0030163|GO:0004842|GO:0032183|GO:0051252|GO:0044265|GO:0010628|GO:0036211|GO:0071560|GO:0031981|GO:0051247|GO:0070848|GO:0006508|GO:0005654|GO:0006259|GO:0030511|GO:0032270|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0006289|GO:0016070|GO:0010557|GO:0005634|GO:0006974|GO:0044257|GO:0045893|GO:0031401|GO:0061630|GO:0010498|GO:0032774|GO:2001141|GO:0071363|GO:0007179|GO:0051603|GO:0007167|GO:0070911|GO:0032184|GO:0046914|GO:0006464|GO:0017015|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006352|GO:0006357|GO:0019941|GO:1903506|GO:0007178|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0006367|GO:0031398|GO:0031396|GO:0030579|GO:0042787|GO:0016567|GO:0000209 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|ligase activity|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|DNA repair|ubiquitin-like protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|regulation of cellular response to growth factor stimulus|intracellular membrane-bounded organelle|SMAD binding|cation binding|cytoplasm|pattern specification process|response to transforming growth factor beta|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|ubiquitin-like protein transferase activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|nucleolus|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|SUMO binding|regulation of RNA metabolic process|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|cellular response to transforming growth factor beta stimulus|nuclear lumen|positive regulation of protein metabolic process|response to growth factor|proteolysis|nucleoplasm|DNA metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of cellular protein metabolic process|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|nucleotide-excision repair|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|cellular protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|ubiquitin protein ligase activity|proteasomal protein catabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|transforming growth factor beta receptor signaling pathway|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|global genome nucleotide-excision repair|SUMO polymer binding|transition metal ion binding|cellular protein modification process|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|transcription initiation from RNA polymerase II promoter|positive regulation of protein ubiquitination|regulation of protein ubiquitination|ubiquitin-dependent SMAD protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 15:58865175-59097419 51 39 67 593 641 597 0.191525661644121 0.133108685800678 0.226854393780484 1.99530660919081 1.9750736562574 2.1011640562235 0.183829580408428 2.0238481072239 -3.46066018016713 1.44314677361237e-37 6.15481482563198e-35 DOWN ENSG00000112339 HBS1L HBS1 like translational GTPase [Source:HGNC Symbol;Acc:HGNC:4834] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0031982|GO:0016817|GO:0007154|GO:0007165|GO:0070062|GO:0000166|GO:0016021|GO:0044249|GO:0019538|GO:0006996|GO:0034645|GO:0006518|GO:1903008|GO:0003723|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0032561|GO:0043043|GO:0032790|GO:0006412|GO:0005525|GO:0008135|GO:0019001|GO:0016462|GO:0006414|GO:0003746|GO:0017111|GO:0003924 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|cell communication|signal transduction|extracellular exosome|nucleotide binding|integral component of membrane|cellular biosynthetic process|protein metabolic process|organelle organization|cellular macromolecule biosynthetic process|peptide metabolic process|organelle disassembly|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|guanyl ribonucleotide binding|peptide biosynthetic process|ribosome disassembly|translation|GTP binding|translation factor activity, RNA binding|guanyl nucleotide binding|pyrophosphatase activity|translational elongation|translation elongation factor activity|nucleoside-triphosphatase activity|GTPase activity K14416 elongation factor 1 alpha-like protein[-] hsa03015|hsa05134 mRNA surveillance pathway - Homo sapiens (human)|Legionellosis - Homo sapiens (human) 6:134960378-135103056 109 136 183 1262 1103 1178 0.470859407424057 0.53392812719105 0.712737902156138 4.88451560457524 3.90937858097396 4.76912426767986 0.572508478923748 4.52100615107635 -2.98127491554541 1.59377253620917e-37 6.70147680225191e-35 DOWN ENSG00000054654 SYNE2 spectrin repeat containing, nuclear envelope 2 [Source:HGNC Symbol;Acc:HGNC:17084] GO:0040011|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0005488|GO:1903561|GO:0042995|GO:0030055|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0042175|GO:0051641|GO:0048870|GO:0040017|GO:0016043|GO:0043227|GO:0019867|GO:0071944|GO:0031252|GO:0031224|GO:0005640|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0030017|GO:0030018|GO:0051272|GO:0051640|GO:0006810|GO:0033017|GO:0005924|GO:0005912|GO:0031982|GO:2000147|GO:0043231|GO:0016234|GO:0051651|GO:0005737|GO:0005635|GO:0006928|GO:0032403|GO:0051656|GO:0030027|GO:0031674|GO:0008104|GO:0007163|GO:0061024|GO:0051270|GO:0016477|GO:0005783|GO:0070062|GO:0051649|GO:0008092|GO:0031256|GO:0031965|GO:0031253|GO:0016021|GO:0030029|GO:2000145|GO:0010256|GO:0006996|GO:0034993|GO:0006998|GO:0016528|GO:0031258|GO:0007010|GO:0030048|GO:0003779|GO:0031022|GO:0016235|GO:0030334|GO:0001667|GO:0046907|GO:0043292|GO:0031981|GO:0032507|GO:0005654|GO:0005739|GO:0051647|GO:0030175|GO:0090286|GO:0034613|GO:0031527|GO:0051015|GO:0051642|GO:0006997|GO:0030335|GO:0005856|GO:0005634|GO:0016529|GO:0040023|GO:0005925|GO:0033365|GO:0030016|GO:0045111|GO:0007097|GO:0030705|GO:0010761|GO:0034504 locomotion|macromolecular complex|cell|membrane|cellular process|extracellular region|cell junction|binding|extracellular vesicle|cell projection|cell-substrate junction|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|cellular localization|cell motility|positive regulation of locomotion|cellular component organization|membrane-bounded organelle|outer membrane|cell periphery|cell leading edge|intrinsic component of membrane|nuclear outer membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|sarcomere|Z disc|positive regulation of cellular component movement|organelle localization|transport|sarcoplasmic reticulum membrane|cell-substrate adherens junction|adherens junction|vesicle|positive regulation of cell motility|intracellular membrane-bounded organelle|inclusion body|maintenance of location in cell|cytoplasm|nuclear envelope|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|lamellipodium|I band|protein localization|establishment or maintenance of cell polarity|membrane organization|regulation of cellular component movement|cell migration|endoplasmic reticulum|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|leading edge membrane|nuclear membrane|cell projection membrane|integral component of membrane|actin filament-based process|regulation of cell motility|endomembrane system organization|organelle organization|LINC complex|nuclear envelope organization|sarcoplasm|lamellipodium membrane|cytoskeleton organization|actin filament-based movement|actin binding|nuclear migration along microfilament|aggresome|regulation of cell migration|ameboidal-type cell migration|intracellular transport|contractile fiber|nuclear lumen|maintenance of protein location in cell|nucleoplasm|mitochondrion|nucleus localization|filopodium|cytoskeletal anchoring at nuclear membrane|cellular protein localization|filopodium membrane|actin filament binding|centrosome localization|nucleus organization|positive regulation of cell migration|cytoskeleton|nucleus|sarcoplasmic reticulum|establishment of nucleus localization|focal adhesion|protein localization to organelle|myofibril|intermediate filament cytoskeleton|nuclear migration|cytoskeleton-dependent intracellular transport|fibroblast migration|protein localization to nucleus - - - - 14:63852983-64226433 375 409 519 3633 3763 5818 0.663174377687355 0.657354858246388 0.82752005379816 5.75651509182397 5.46007781624412 9.6427138582237 0.716016429910634 6.9531022554306 -3.27959220914373 1.81101317912207e-37 7.50916492354309e-35 DOWN ENSG00000124767 GLO1 glyoxalase I [Source:HGNC Symbol;Acc:HGNC:4323] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0048523|GO:0050794|GO:0006807|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0002520|GO:0048856|GO:0019222|GO:0006575|GO:0006081|GO:0016846|GO:0006725|GO:1901360|GO:0010941|GO:0006082|GO:0007275|GO:0048513|GO:0034641|GO:0044281|GO:0031982|GO:0046483|GO:0043169|GO:0005737|GO:0005975|GO:0060548|GO:0006139|GO:0070062|GO:0042180|GO:0008219|GO:0048869|GO:0044249|GO:0031323|GO:0006790|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0030097|GO:0043069|GO:0051252|GO:0009438|GO:0004462|GO:0006749|GO:0012501|GO:0043603|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0043067|GO:0002521|GO:0032774|GO:2001141|GO:0042981|GO:0046914|GO:0043066|GO:0019752|GO:0030099|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:0002573|GO:0006357|GO:1903506|GO:0032787|GO:0008270|GO:0030316|GO:0006090 developmental process|immune system process|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|immune system development|anatomical structure development|regulation of metabolic process|cellular modified amino acid metabolic process|cellular aldehyde metabolic process|carbon-sulfur lyase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|heterocycle metabolic process|cation binding|cytoplasm|carbohydrate metabolic process|negative regulation of cell death|nucleobase-containing compound metabolic process|extracellular exosome|cellular ketone metabolic process|cell death|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|sulfur compound metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|hemopoiesis|negative regulation of programmed cell death|regulation of RNA metabolic process|methylglyoxal metabolic process|lactoylglutathione lyase activity|glutathione metabolic process|programmed cell death|cellular amide metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|regulation of programmed cell death|leukocyte differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of apoptotic process|transition metal ion binding|negative regulation of apoptotic process|carboxylic acid metabolic process|myeloid cell differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|myeloid leukocyte differentiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|monocarboxylic acid metabolic process|zinc ion binding|osteoclast differentiation|pyruvate metabolic process K01759 lactoylglutathione lyase[4.4.1.5] hsa00620 Pyruvate metabolism - Homo sapiens (human) 6:38675925-38703141 409 398 557 3195 3685 2866 7.49323636240661 6.62688605977348 9.20058893017197 52.4462562779731 55.3925508481958 49.209733466505 7.77357045078402 52.3495135308913 -2.75152683560637 3.12392150363776e-37 1.27755551465208e-34 DOWN ENSG00000132466 ANKRD17 ankyrin repeat domain 17 [Source:HGNC Symbol;Acc:HGNC:23575] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0000785|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0019222|GO:0016032|GO:0002757|GO:0051726|GO:0007049|GO:0045087|GO:0045595|GO:0006725|GO:0022402|GO:1901360|GO:0001568|GO:0007275|GO:0050688|GO:0003676|GO:0045596|GO:0034641|GO:0006952|GO:0039528|GO:0046483|GO:0098542|GO:0001817|GO:0061061|GO:0043231|GO:1900246|GO:0005737|GO:0002218|GO:0001816|GO:0009615|GO:0009966|GO:0045787|GO:0003682|GO:0001819|GO:0010646|GO:0006139|GO:0009617|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0051607|GO:0048869|GO:0009967|GO:0044249|GO:0031323|GO:1900245|GO:1902533|GO:0034645|GO:0039530|GO:0090068|GO:0001955|GO:0003723|GO:1903047|GO:0001944|GO:0002758|GO:0072358|GO:0042692|GO:0044770|GO:0051147|GO:0039529|GO:0000278|GO:0098586|GO:0007346|GO:0010564|GO:0006259|GO:0005694|GO:0002764|GO:0035556|GO:0042742|GO:0009059|GO:0030154|GO:1902531|GO:0045931|GO:0072359|GO:0005634|GO:0051148|GO:0045089|GO:0030522|GO:0045088|GO:0006260|GO:0043122|GO:0051145|GO:0044772|GO:0051151|GO:0002221|GO:1901990|GO:1901989|GO:0043123|GO:1901992|GO:0007249|GO:0006275|GO:0044822|GO:1901987|GO:0051150|GO:0039535|GO:1900087|GO:2000045|GO:1902808|GO:1902806|GO:0000082 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|chromatin|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|anatomical structure development|regulation of metabolic process|viral process|immune response-activating signal transduction|regulation of cell cycle|cell cycle|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|regulation of defense response to virus|nucleic acid binding|negative regulation of cell differentiation|cellular nitrogen compound metabolic process|defense response|cytoplasmic pattern recognition receptor signaling pathway in response to virus|heterocycle metabolic process|defense response to other organism|regulation of cytokine production|muscle structure development|intracellular membrane-bounded organelle|positive regulation of RIG-I signaling pathway|cytoplasm|activation of innate immune response|cytokine production|response to virus|regulation of signal transduction|positive regulation of cell cycle|chromatin binding|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|defense response to virus|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|positive regulation of MDA-5 signaling pathway|positive regulation of intracellular signal transduction|cellular macromolecule biosynthetic process|MDA-5 signaling pathway|positive regulation of cell cycle process|blood vessel maturation|RNA binding|mitotic cell cycle process|vasculature development|innate immune response-activating signal transduction|cardiovascular system development|muscle cell differentiation|cell cycle phase transition|regulation of muscle cell differentiation|RIG-I signaling pathway|mitotic cell cycle|cellular response to virus|regulation of mitotic cell cycle|regulation of cell cycle process|DNA metabolic process|chromosome|immune response-regulating signaling pathway|intracellular signal transduction|defense response to bacterium|macromolecule biosynthetic process|cell differentiation|regulation of intracellular signal transduction|positive regulation of mitotic cell cycle|circulatory system development|nucleus|negative regulation of muscle cell differentiation|positive regulation of innate immune response|intracellular receptor signaling pathway|regulation of innate immune response|DNA replication|regulation of I-kappaB kinase/NF-kappaB signaling|smooth muscle cell differentiation|mitotic cell cycle phase transition|negative regulation of smooth muscle cell differentiation|pattern recognition receptor signaling pathway|regulation of mitotic cell cycle phase transition|positive regulation of cell cycle phase transition|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of mitotic cell cycle phase transition|I-kappaB kinase/NF-kappaB signaling|regulation of DNA replication|poly(A) RNA binding|regulation of cell cycle phase transition|regulation of smooth muscle cell differentiation|regulation of RIG-I signaling pathway|positive regulation of G1/S transition of mitotic cell cycle|regulation of G1/S transition of mitotic cell cycle|positive regulation of cell cycle G1/S phase transition|regulation of cell cycle G1/S phase transition|G1/S transition of mitotic cell cycle - - - - 4:73073376-73258798 333 293 293 2247 2577 2253 1.51852564256033 1.21429924792581 1.20464599164415 9.18076321562405 9.64184919199403 9.62870950177964 1.31249029404343 9.48377396979924 -2.85315452497062 4.37559808392033e-37 1.76525817834267e-34 DOWN ENSG00000114127 XRN1 5'-3' exoribonuclease 1 [Source:HGNC Symbol;Acc:HGNC:30654] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0043487|GO:0005794|GO:0005829|GO:0003677|GO:0010468|GO:0003723|GO:0044265|GO:0004518|GO:0010467|GO:0019439|GO:0016070|GO:0005856|GO:0005634|GO:0043488|GO:0006401|GO:0034660|GO:0010608|GO:0004527|GO:0016071|GO:0045111|GO:0044822|GO:0090305|GO:0006402|GO:0008334|GO:0016072|GO:0071025|GO:0008409|GO:0071044|GO:0000956|GO:0016075|GO:0000291|GO:0071028|GO:0000288|GO:0043928 cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|endomembrane system|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|regulation of RNA stability|Golgi apparatus|cytosol|DNA binding|regulation of gene expression|RNA binding|cellular macromolecule catabolic process|nuclease activity|gene expression|aromatic compound catabolic process|RNA metabolic process|cytoskeleton|nucleus|regulation of mRNA stability|RNA catabolic process|ncRNA metabolic process|posttranscriptional regulation of gene expression|exonuclease activity|mRNA metabolic process|intermediate filament cytoskeleton|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|mRNA catabolic process|histone mRNA metabolic process|rRNA metabolic process|RNA surveillance|5'-3' exonuclease activity|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process|rRNA catabolic process|nuclear-transcribed mRNA catabolic process, exonucleolytic|nuclear mRNA surveillance|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay K12618 5'-3' exoribonuclease 1 [EC:3.1.13.-][-] hsa03008|hsa03018 Ribosome biogenesis in eukaryotes - Homo sapiens (human)|RNA degradation - Homo sapiens (human) 3:142306607-142448062 105 102 143 996 1023 1413 0.415030651809134 0.366411757491344 0.50961264060639 3.52733646040511 3.31767156369652 5.23432803509347 0.430351683302289 4.02644535306503 -3.2259187362721 6.17375005693068e-37 2.45748178932811e-34 DOWN ENSG00000183495 EP400 E1A binding protein p400 [Source:HGNC Symbol;Acc:HGNC:11958] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0044877|GO:0043229|GO:0071704|GO:0043167|GO:0003823|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0016570|GO:0003676|GO:0043168|GO:0001882|GO:0016817|GO:0070603|GO:0043231|GO:1990405|GO:0003682|GO:0000790|GO:0000166|GO:0019538|GO:0006996|GO:0051276|GO:0003677|GO:0035639|GO:0043412|GO:0006325|GO:0001883|GO:0000812|GO:0016573|GO:0016818|GO:0036211|GO:0032549|GO:0031981|GO:1990234|GO:0005654|GO:0005694|GO:0000228|GO:0044267|GO:0017076|GO:0000123|GO:0005634|GO:0005524|GO:0043968|GO:0043967|GO:0030554|GO:0016604|GO:0016568|GO:0006464|GO:0016462|GO:0016607|GO:0017111|GO:0018193|GO:0043189|GO:0035267|GO:0006473|GO:0004386|GO:0018205|GO:0018394|GO:0006475|GO:0018393 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|organic substance metabolic process|ion binding|antigen binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|histone modification|nucleic acid binding|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|protein antigen binding|chromatin binding|nuclear chromatin|nucleotide binding|protein metabolic process|organelle organization|chromosome organization|DNA binding|purine ribonucleoside triphosphate binding|macromolecule modification|chromatin organization|purine nucleoside binding|Swr1 complex|histone acetylation|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|ribonucleoside binding|nuclear lumen|transferase complex|nucleoplasm|chromosome|nuclear chromosome|cellular protein metabolic process|purine nucleotide binding|histone acetyltransferase complex|nucleus|ATP binding|histone H2A acetylation|histone H4 acetylation|adenyl nucleotide binding|nuclear body|chromatin modification|cellular protein modification process|pyrophosphatase activity|nuclear speck|nucleoside-triphosphatase activity|peptidyl-amino acid modification|H4/H2A histone acetyltransferase complex|NuA4 histone acetyltransferase complex|protein acetylation|helicase activity|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation - - - - 12:131949920-132081102 121 119 228 1317 1539 1564 0.292062779393155 0.261046180716138 0.496178098857853 2.84821516894074 3.04786441945768 3.53797691153946 0.349762352989049 3.14468549997929 -3.16846882353176 8.03018731339255e-37 3.15438436913186e-34 DOWN ENSG00000114423 CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:1542] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0071944|GO:0016874|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0051219|GO:0006810|GO:0009629|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0009725|GO:0019787|GO:0019538|GO:0010033|GO:0098857|GO:0005829|GO:0046872|GO:0007166|GO:0043412|GO:0072594|GO:0004842|GO:0015031|GO:0036211|GO:0046907|GO:0031981|GO:0005654|GO:0034613|GO:0019900|GO:0045309|GO:0044267|GO:0017038|GO:0045121|GO:0005634|GO:0006606|GO:0033365|GO:0051169|GO:0001784|GO:0006607|GO:0006605|GO:0005509|GO:0006886|GO:0046914|GO:0019901|GO:0006464|GO:0006913|GO:0008270|GO:0034504|GO:0032446|GO:0051170|GO:0016567 signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|cell periphery|ligase activity|intracellular|protein binding|plasma membrane|transferase activity|phosphoprotein binding|transport|response to gravity|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|establishment of localization in cell|response to hormone|ubiquitin-like protein transferase activity|protein metabolic process|response to organic substance|membrane microdomain|cytosol|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|establishment of protein localization to organelle|ubiquitin-protein transferase activity|protein transport|protein modification process|intracellular transport|nuclear lumen|nucleoplasm|cellular protein localization|kinase binding|protein phosphorylated amino acid binding|cellular protein metabolic process|protein import|membrane raft|nucleus|protein import into nucleus|protein localization to organelle|nuclear transport|phosphotyrosine binding|NLS-bearing protein import into nucleus|protein targeting|calcium ion binding|intracellular protein transport|transition metal ion binding|protein kinase binding|cellular protein modification process|nucleocytoplasmic transport|zinc ion binding|protein localization to nucleus|protein modification by small protein conjugation|nuclear import|protein ubiquitination K04707 E3 ubiquitin-protein ligase CBL[2.3.2.27] hsa05200|hsa04144|hsa05205|hsa04910|hsa04120|hsa05162|hsa04660|hsa04012|hsa05100|hsa05220 Pathways in cancer - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human)|Measles - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human) 3:105655461-105869552 33 35 83 767 800 965 0.155485710298594 0.149875840766356 0.352588519605867 3.23795903117532 3.09268835023646 4.26122581756103 0.219316690223606 3.5306243996576 -4.00883583838222 8.57633335490611e-37 3.32516696074503e-34 DOWN ENSG00000066279 ASPM abnormal spindle microtubule assembly [Source:HGNC Symbol;Acc:HGNC:19048] GO:0040011|GO:0032502|GO:0040007|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0030496|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0044702|GO:0051321|GO:0019953|GO:0051641|GO:0003006|GO:0048870|GO:0023051|GO:0016043|GO:0043227|GO:0032504|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0045137|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0045595|GO:0000212|GO:0051640|GO:0048468|GO:0022402|GO:0007275|GO:0045596|GO:0048513|GO:0051302|GO:0005874|GO:0030900|GO:0007420|GO:0022607|GO:0045597|GO:0043231|GO:0048608|GO:0051651|GO:0005737|GO:0060322|GO:0021987|GO:0006928|GO:0009966|GO:0007548|GO:0051782|GO:0051445|GO:0010646|GO:0008406|GO:0005516|GO:0007154|GO:0007276|GO:0016477|GO:0007165|GO:0007126|GO:0061351|GO:0021543|GO:0051301|GO:0048869|GO:0021537|GO:0009967|GO:0007017|GO:0019827|GO:0007281|GO:0006996|GO:0072089|GO:0050768|GO:0030111|GO:0051661|GO:0051653|GO:0045769|GO:1990752|GO:0008584|GO:0048232|GO:0007166|GO:1903047|GO:0046661|GO:0007010|GO:0061458|GO:0007417|GO:0010720|GO:0007405|GO:0010721|GO:0097150|GO:0048477|GO:0009786|GO:0000278|GO:0001764|GO:0036449|GO:0050769|GO:0007051|GO:0006461|GO:0021872|GO:0070925|GO:0051642|GO:0007067|GO:2000179|GO:0007399|GO:0008356|GO:0090306|GO:0030177|GO:0017145|GO:0030154|GO:2000177|GO:0000226|GO:0007292|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0051960|GO:2000648|GO:0046546|GO:0072091|GO:0030182|GO:0016055|GO:0007283|GO:0051225|GO:0072687|GO:0072686|GO:0060828|GO:1902692|GO:0048103|GO:0097431|GO:0015630|GO:0021873|GO:0045665|GO:0022008|GO:0050767|GO:0090263|GO:0002052|GO:0048699|GO:0060070|GO:0045664 locomotion|developmental process|growth|reproduction|signaling|cell|cellular process|reproductive process|response to stimulus|binding|midbody|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|single organism reproductive process|meiotic cell cycle|sexual reproduction|cellular localization|developmental process involved in reproduction|cell motility|regulation of signaling|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|regulation of developmental process|developmental growth|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|development of primary sexual characteristics|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of cell differentiation|meiotic spindle organization|organelle localization|cell development|cell cycle process|multicellular organism development|negative regulation of cell differentiation|animal organ development|regulation of cell division|microtubule|forebrain development|brain development|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|maintenance of location in cell|cytoplasm|head development|cerebral cortex development|movement of cell or subcellular component|regulation of signal transduction|sex differentiation|negative regulation of cell division|regulation of meiotic cell cycle|regulation of cell communication|gonad development|calmodulin binding|cell communication|gamete generation|cell migration|signal transduction|meiotic nuclear division|neural precursor cell proliferation|pallium development|cell division|cellular developmental process|telencephalon development|positive regulation of signal transduction|microtubule-based process|stem cell population maintenance|germ cell development|organelle organization|stem cell proliferation|negative regulation of neurogenesis|regulation of Wnt signaling pathway|maintenance of centrosome location|spindle localization|negative regulation of asymmetric cell division|microtubule end|male gonad development|male gamete generation|cell surface receptor signaling pathway|mitotic cell cycle process|male sex differentiation|cytoskeleton organization|reproductive system development|central nervous system development|positive regulation of cell development|neuroblast proliferation|negative regulation of cell development|neuronal stem cell population maintenance|oogenesis|regulation of asymmetric cell division|mitotic cell cycle|neuron migration|microtubule minus-end|positive regulation of neurogenesis|spindle organization|protein complex assembly|forebrain generation of neurons|organelle assembly|centrosome localization|mitotic nuclear division|positive regulation of neural precursor cell proliferation|nervous system development|asymmetric cell division|spindle assembly involved in meiosis|positive regulation of Wnt signaling pathway|stem cell division|cell differentiation|regulation of neural precursor cell proliferation|microtubule cytoskeleton organization|female gamete generation|cytoskeleton|spindle pole|nucleus|spindle|regulation of nervous system development|positive regulation of stem cell proliferation|development of primary male sexual characteristics|regulation of stem cell proliferation|neuron differentiation|Wnt signaling pathway|spermatogenesis|spindle assembly|meiotic spindle|mitotic spindle|regulation of canonical Wnt signaling pathway|regulation of neuroblast proliferation|somatic stem cell division|mitotic spindle pole|microtubule cytoskeleton|forebrain neuroblast division|negative regulation of neuron differentiation|neurogenesis|regulation of neurogenesis|positive regulation of canonical Wnt signaling pathway|positive regulation of neuroblast proliferation|generation of neurons|canonical Wnt signaling pathway|regulation of neuron differentiation - - - - 1:197084128-197146694 389 537 654 3493 3934 4252 1.99453813245431 2.50234210213962 3.02332400929188 16.0468141768607 16.5498813793166 20.4321824264105 2.50673474796194 17.6762926608626 -2.8179344731658 1.23117526141313e-36 4.65259572838324e-34 DOWN ENSG00000140718 FTO fat mass and obesity associated [Source:HGNC Symbol;Acc:HGNC:24678] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032451|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0040008|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0048856|GO:0043576|GO:0042127|GO:0007585|GO:0006281|GO:0010883|GO:0006725|GO:0009888|GO:0051213|GO:1901360|GO:0080111|GO:0007275|GO:0048513|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0035515|GO:0016705|GO:0035516|GO:0035264|GO:0042592|GO:0070988|GO:0048871|GO:0006139|GO:0003016|GO:0048638|GO:0040014|GO:0019915|GO:0016021|GO:0010876|GO:0055114|GO:0035511|GO:0070989|GO:0035553|GO:0046872|GO:0043412|GO:0001659|GO:0031981|GO:0016706|GO:0005654|GO:0006259|GO:0044065|GO:0061448|GO:0016070|GO:0005634|GO:0006974|GO:0060612|GO:0006307|GO:0009451|GO:0070350|GO:0016604|GO:0006304|GO:0035552|GO:0042245|GO:0043734|GO:0046914|GO:0016607|GO:0005506|GO:0008198 developmental process|growth|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|demethylase activity|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|regulation of growth|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|anatomical structure development|regulation of respiratory gaseous exchange|regulation of cell proliferation|respiratory gaseous exchange|DNA repair|regulation of lipid storage|cellular aromatic compound metabolic process|tissue development|dioxygenase activity|organic cyclic compound metabolic process|DNA demethylation|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|oxidative RNA demethylase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidative DNA demethylase activity|multicellular organism growth|homeostatic process|demethylation|multicellular organismal homeostasis|nucleobase-containing compound metabolic process|respiratory system process|regulation of developmental growth|regulation of multicellular organism growth|lipid storage|integral component of membrane|lipid localization|oxidation-reduction process|oxidative DNA demethylation|oxidative demethylation|oxidative single-stranded RNA demethylation|metal ion binding|macromolecule modification|temperature homeostasis|nuclear lumen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|nucleoplasm|DNA metabolic process|regulation of respiratory system process|connective tissue development|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|adipose tissue development|DNA dealkylation involved in DNA repair|RNA modification|regulation of white fat cell proliferation|nuclear body|DNA modification|oxidative single-stranded DNA demethylation|RNA repair|DNA-N1-methyladenine dioxygenase activity|transition metal ion binding|nuclear speck|iron ion binding|ferrous iron binding - - - - 16:53703963-54121941 58 65 132 1052 1060 1438 0.225103996150569 0.22927164818377 0.461895238588005 3.65820327032638 3.37542301014765 5.23048884564506 0.305423627640781 4.08803837537303 -3.74252516047646 1.21964301330056e-36 4.65259572838324e-34 DOWN ENSG00000136205 TNS3 tensin 3 [Source:HGNC Symbol;Acc:HGNC:21616] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0030055|GO:0008283|GO:0050794|GO:0043167|GO:0048870|GO:0005622|GO:0005515|GO:0048856|GO:0008284|GO:0042127|GO:0048286|GO:0035295|GO:0007275|GO:0030324|GO:0048513|GO:0005924|GO:0005912|GO:0043169|GO:0005737|GO:0006928|GO:0030323|GO:0007154|GO:0016477|GO:0007165|GO:0046872|GO:0060541|GO:0035556|GO:0005925 locomotion|developmental process|signaling|cell|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell-substrate junction|cell proliferation|regulation of cellular process|ion binding|cell motility|intracellular|protein binding|anatomical structure development|positive regulation of cell proliferation|regulation of cell proliferation|lung alveolus development|tube development|multicellular organism development|lung development|animal organ development|cell-substrate adherens junction|adherens junction|cation binding|cytoplasm|movement of cell or subcellular component|respiratory tube development|cell communication|cell migration|signal transduction|metal ion binding|respiratory system development|intracellular signal transduction|focal adhesion - - - - 7:47275154-47582558 375 369 686 3950 4411 4547 1.62478941155926 1.45302247285523 2.67981189193507 15.334184992834 15.6808985709241 18.46374811512 1.91920792544985 16.4929438929594 -3.10326600875547 1.36116572099815e-36 5.07953017933484e-34 DOWN ENSG00000138814 PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme [Source:HGNC Symbol;Acc:HGNC:9314] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0008144|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0016787|GO:0009058|GO:0008287|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0030017|GO:0060341|GO:0030018|GO:0002757|GO:0007049|GO:0016337|GO:0050804|GO:0042391|GO:0045087|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:0022402|GO:1901360|GO:0007275|GO:0045596|GO:0048513|GO:0070489|GO:0016358|GO:0034641|GO:0016788|GO:0032940|GO:0006952|GO:0031325|GO:0046483|GO:0051128|GO:0098609|GO:0051098|GO:0061061|GO:0043231|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0003012|GO:0002218|GO:0007267|GO:0005955|GO:0032880|GO:0051222|GO:0042592|GO:0001775|GO:0046983|GO:0045184|GO:0046883|GO:0042383|GO:0019725|GO:0031674|GO:0042493|GO:0032388|GO:0010646|GO:0006139|GO:0050776|GO:1900182|GO:0008104|GO:0046649|GO:0005516|GO:0007154|GO:0044092|GO:0033555|GO:0007165|GO:0050778|GO:0051649|GO:0046888|GO:0090316|GO:0051048|GO:1903531|GO:0030030|GO:0010817|GO:0048869|GO:0010035|GO:0044249|GO:0019538|GO:0010033|GO:0051224|GO:0031323|GO:0051090|GO:0050768|GO:0000902|GO:0042307|GO:0014733|GO:0005829|GO:0031175|GO:0009743|GO:2000171|GO:0031344|GO:0010468|GO:0034645|GO:0010613|GO:0046872|GO:0007166|GO:0090276|GO:0051100|GO:1903047|GO:0043412|GO:0072594|GO:0002758|GO:0050773|GO:0042692|GO:0046982|GO:0048878|GO:0048813|GO:0051252|GO:0032386|GO:0050709|GO:0060078|GO:0044770|GO:0010721|GO:0051223|GO:0015031|GO:0000904|GO:0090257|GO:0010628|GO:0010038|GO:0036211|GO:0000278|GO:0070201|GO:0060537|GO:0046907|GO:0042886|GO:0006811|GO:0055082|GO:0031345|GO:0051091|GO:0002429|GO:0051046|GO:0043292|GO:0031981|GO:0007159|GO:0009914|GO:0009306|GO:0005654|GO:0022604|GO:0005739|GO:0002764|GO:0055001|GO:1904591|GO:0034613|GO:0042110|GO:0006796|GO:0035556|GO:0002792|GO:0044267|GO:0014075|GO:0010611|GO:0014896|GO:0010467|GO:0017038|GO:0032990|GO:0007399|GO:0046903|GO:0071310|GO:0031328|GO:0035690|GO:0009059|GO:0030154|GO:0048858|GO:0007517|GO:1903827|GO:0016070|GO:0010557|GO:0005634|GO:0042578|GO:0045089|GO:0006606|GO:0051960|GO:0014898|GO:0045088|GO:1903242|GO:0048666|GO:0030182|GO:0050796|GO:0055002|GO:0071322|GO:0002790|GO:1904589|GO:0060538|GO:0045893|GO:0016311|GO:0030073|GO:0010975|GO:0033365|GO:0033157|GO:0030016|GO:0001678|GO:0051169|GO:0010769|GO:0046676|GO:0032774|GO:0044772|GO:0006812|GO:0051592|GO:2001141|GO:0034284|GO:0050708|GO:0015833|GO:0006605|GO:0002768|GO:0005509|GO:0070486|GO:0016482|GO:0035562|GO:0006886|GO:0048814|GO:0001975|GO:0042993|GO:0051146|GO:0016791|GO:0060079|GO:0050774|GO:0042306|GO:0045665|GO:1900180|GO:0014706|GO:1903244|GO:0022008|GO:0048667|GO:0006464|GO:0019932|GO:0050767|GO:0048812|GO:0042991|GO:0046879|GO:0010977|GO:0006351|GO:0006355|GO:0014883|GO:0033500|GO:0046824|GO:0006470|GO:0003300|GO:0071333|GO:0042593|GO:1903533|GO:0045944|GO:0006366|GO:0030072|GO:0006913|GO:0002223|GO:0006357|GO:0048699|GO:0007519|GO:1903506|GO:0004721|GO:0051533|GO:0048747|GO:0051531|GO:0038093|GO:0000082|GO:0014902|GO:0030001|GO:0019722|GO:0014904|GO:0048016|GO:0042990|GO:0071593|GO:0045664|GO:0034504|GO:0046822|GO:0007268|GO:0004722|GO:0051170|GO:0048741|GO:0038095|GO:0033173|GO:0009749|GO:0006816|GO:0004723|GO:0033192 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|immune response|drug binding|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|biosynthetic process|protein serine/threonine phosphatase complex|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|sarcomere|regulation of cellular localization|Z disc|immune response-activating signal transduction|cell cycle|single organismal cell-cell adhesion|modulation of synaptic transmission|regulation of membrane potential|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|transport|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|negative regulation of cell differentiation|animal organ development|T cell aggregation|dendrite development|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|secretion by cell|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cell-cell adhesion|regulation of binding|muscle structure development|intracellular membrane-bounded organelle|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|muscle system process|activation of innate immune response|cell-cell signaling|calcineurin complex|regulation of protein localization|positive regulation of protein transport|homeostatic process|cell activation|protein dimerization activity|establishment of protein localization|regulation of hormone secretion|sarcolemma|cellular homeostasis|I band|response to drug|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|regulation of immune response|positive regulation of protein localization to nucleus|protein localization|lymphocyte activation|calmodulin binding|cell communication|negative regulation of molecular function|multicellular organismal response to stress|signal transduction|positive regulation of immune response|establishment of localization in cell|negative regulation of hormone secretion|positive regulation of intracellular protein transport|negative regulation of secretion|negative regulation of secretion by cell|cell projection organization|regulation of hormone levels|cellular developmental process|response to inorganic substance|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of protein transport|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|negative regulation of neurogenesis|cell morphogenesis|positive regulation of protein import into nucleus|regulation of skeletal muscle adaptation|cytosol|neuron projection development|response to carbohydrate|negative regulation of dendrite development|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|positive regulation of cardiac muscle hypertrophy|metal ion binding|cell surface receptor signaling pathway|regulation of peptide hormone secretion|negative regulation of binding|mitotic cell cycle process|macromolecule modification|establishment of protein localization to organelle|innate immune response-activating signal transduction|regulation of dendrite development|muscle cell differentiation|protein heterodimerization activity|chemical homeostasis|dendrite morphogenesis|regulation of RNA metabolic process|regulation of intracellular transport|negative regulation of protein secretion|regulation of postsynaptic membrane potential|cell cycle phase transition|negative regulation of cell development|regulation of protein transport|protein transport|cell morphogenesis involved in differentiation|regulation of muscle system process|positive regulation of gene expression|response to metal ion|protein modification process|mitotic cell cycle|regulation of establishment of protein localization|muscle tissue development|intracellular transport|amide transport|ion transport|cellular chemical homeostasis|negative regulation of cell projection organization|positive regulation of sequence-specific DNA binding transcription factor activity|immune response-activating cell surface receptor signaling pathway|regulation of secretion|contractile fiber|nuclear lumen|leukocyte cell-cell adhesion|hormone transport|protein secretion|nucleoplasm|regulation of cell morphogenesis|mitochondrion|immune response-regulating signaling pathway|muscle cell development|positive regulation of protein import|cellular protein localization|T cell activation|phosphate-containing compound metabolic process|intracellular signal transduction|negative regulation of peptide secretion|cellular protein metabolic process|response to amine|regulation of cardiac muscle hypertrophy|muscle hypertrophy|gene expression|protein import|cell part morphogenesis|nervous system development|secretion|cellular response to organic substance|positive regulation of cellular biosynthetic process|cellular response to drug|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|muscle organ development|regulation of cellular protein localization|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|phosphoric ester hydrolase activity|positive regulation of innate immune response|protein import into nucleus|regulation of nervous system development|cardiac muscle hypertrophy in response to stress|regulation of innate immune response|regulation of cardiac muscle hypertrophy in response to stress|neuron development|neuron differentiation|regulation of insulin secretion|striated muscle cell development|cellular response to carbohydrate stimulus|peptide secretion|regulation of protein import|skeletal muscle organ development|positive regulation of transcription, DNA-templated|dephosphorylation|insulin secretion|regulation of neuron projection development|protein localization to organelle|regulation of intracellular protein transport|myofibril|cellular glucose homeostasis|nuclear transport|regulation of cell morphogenesis involved in differentiation|negative regulation of insulin secretion|RNA biosynthetic process|mitotic cell cycle phase transition|cation transport|response to calcium ion|regulation of RNA biosynthetic process|response to monosaccharide|regulation of protein secretion|peptide transport|protein targeting|immune response-regulating cell surface receptor signaling pathway|calcium ion binding|leukocyte aggregation|cytosolic transport|negative regulation of chromatin binding|intracellular protein transport|regulation of dendrite morphogenesis|response to amphetamine|positive regulation of transcription factor import into nucleus|striated muscle cell differentiation|phosphatase activity|excitatory postsynaptic potential|negative regulation of dendrite morphogenesis|regulation of protein import into nucleus|negative regulation of neuron differentiation|regulation of protein localization to nucleus|striated muscle tissue development|positive regulation of cardiac muscle hypertrophy in response to stress|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|second-messenger-mediated signaling|regulation of neurogenesis|neuron projection morphogenesis|transcription factor import into nucleus|hormone secretion|negative regulation of neuron projection development|transcription, DNA-templated|regulation of transcription, DNA-templated|transition between fast and slow fiber|carbohydrate homeostasis|positive regulation of nucleocytoplasmic transport|protein dephosphorylation|cardiac muscle hypertrophy|cellular response to glucose stimulus|glucose homeostasis|regulation of protein targeting|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|nucleocytoplasmic transport|stimulatory C-type lectin receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|generation of neurons|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|phosphoprotein phosphatase activity|positive regulation of NFAT protein import into nucleus|muscle fiber development|NFAT protein import into nucleus|Fc receptor signaling pathway|G1/S transition of mitotic cell cycle|myotube differentiation|metal ion transport|calcium-mediated signaling|myotube cell development|inositol phosphate-mediated signaling|regulation of transcription factor import into nucleus|lymphocyte aggregation|regulation of neuron differentiation|protein localization to nucleus|regulation of nucleocytoplasmic transport|synaptic transmission|protein serine/threonine phosphatase activity|nuclear import|skeletal muscle fiber development|Fc-epsilon receptor signaling pathway|calcineurin-NFAT signaling cascade|response to glucose|calcium ion transport|calcium-dependent protein serine/threonine phosphatase activity|calmodulin-dependent protein phosphatase activity K04348 serine/threonine-protein phosphatase 2B catalytic subunit[3.1.3.16] hsa05166|hsa04010|hsa04020|hsa05152|hsa04360|hsa05010|hsa04022|hsa04921|hsa04310|hsa04650|hsa04380|hsa04728|hsa04114|hsa04724|hsa04660|hsa04922|hsa04662|hsa05031|hsa04720|hsa04924|hsa04370|hsa05014 HTLV-I infection - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Renin secretion - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) 4:101023409-101348278 143 156 261 1450 1571 1503 0.657057256167869 0.651433525452084 1.08123661622884 5.96941595360391 5.92257111931081 6.47222843569545 0.796575799282931 6.12140516953672 -2.94197930675433 1.65032649034797e-36 6.08257370899362e-34 DOWN ENSG00000146463 ZMYM4 zinc finger, MYM-type 4 [Source:HGNC Symbol;Acc:HGNC:13055] GO:0032502|GO:0009987|GO:0005488|GO:0097159|GO:0050794|GO:0043167|GO:0009653|GO:0016043|GO:0050793|GO:0005515|GO:0048856|GO:0007275|GO:0003676|GO:0051128|GO:0043169|GO:0048869|GO:0006996|GO:0000902|GO:0003677|GO:0046872|GO:0007010|GO:0022604|GO:0046914|GO:0008270 developmental process|cellular process|binding|organic cyclic compound binding|regulation of cellular process|ion binding|anatomical structure morphogenesis|cellular component organization|regulation of developmental process|protein binding|anatomical structure development|multicellular organism development|nucleic acid binding|regulation of cellular component organization|cation binding|cellular developmental process|organelle organization|cell morphogenesis|DNA binding|metal ion binding|cytoskeleton organization|regulation of cell morphogenesis|transition metal ion binding|zinc ion binding - - - - 1:35268967-35422058 237 292 428 2318 2577 2317 1.48123488422225 1.6585874012271 2.41175755634408 12.9803745573702 13.214734464235 13.5716021938313 1.85052661393114 13.2555704051455 -2.84059096318932 2.99894446440021e-36 1.09183522000249e-33 DOWN ENSG00000141429 GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:4123] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0048471|GO:0070085|GO:0005795|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0018242|GO:0031985|GO:0032580|GO:0046914|GO:0018243|GO:0008376|GO:0006464|GO:0016266|GO:0004653|GO:0030145|GO:0018193|GO:0043687 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|perinuclear region of cytoplasm|glycosylation|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|protein O-linked glycosylation via serine|Golgi cisterna|Golgi cisterna membrane|transition metal ion binding|protein O-linked glycosylation via threonine|acetylgalactosaminyltransferase activity|cellular protein modification process|O-glycan processing|polypeptide N-acetylgalactosaminyltransferase activity|manganese ion binding|peptidyl-amino acid modification|post-translational protein modification K00710 polypeptide N-acetylgalactosaminyltransferase[2.4.1.41] hsa01100|hsa00512 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human) 18:35581117-35711834 175 184 375 2382 2826 2671 1.75712373796941 1.67904380163929 3.39476726606204 21.429116475618 23.2811766288686 25.1343418992564 2.27697826855691 23.2815450012477 -3.35399437342068 3.4948156482301e-36 1.25703887183447e-33 DOWN ENSG00000128833 MYO5C myosin VC [Source:HGNC Symbol;Acc:HGNC:7604] GO:0032991|GO:0005623|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0043168|GO:0001882|GO:0031982|GO:0016817|GO:0016459|GO:0005516|GO:0070062|GO:0008092|GO:0000166|GO:0035639|GO:0001883|GO:0003779|GO:0016818|GO:0032549|GO:0017076|GO:0005856|GO:0015629|GO:0005524|GO:0030554|GO:0016462|GO:0017111|GO:0003774 macromolecular complex|cell|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|anion binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|myosin complex|calmodulin binding|extracellular exosome|cytoskeletal protein binding|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|actin binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|purine nucleotide binding|cytoskeleton|actin cytoskeleton|ATP binding|adenyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|motor activity - - - - 15:52192322-52295798 93 82 99 827 903 710 0.487045200892085 0.390283465646235 0.467450971850914 3.88052134856156 3.88009811978494 3.48477105391379 0.448259879463078 3.7484635074201 -3.06389207212128 4.23647190299618e-36 1.50566228800057e-33 DOWN ENSG00000140455 USP3 ubiquitin specific peptidase 3 [Source:HGNC Symbol;Acc:HGNC:12626] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0007049|GO:0006281|GO:0006725|GO:0042393|GO:1901360|GO:0016570|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0006139|GO:0000790|GO:0031647|GO:0019538|GO:0006996|GO:0051276|GO:0036459|GO:0046872|GO:0016578|GO:0043412|GO:0030163|GO:0006325|GO:0044265|GO:0036211|GO:0000278|GO:0031981|GO:0006508|GO:0006259|GO:0005694|GO:0000228|GO:0044267|GO:0005634|GO:0006974|GO:0044257|GO:0051603|GO:0070646|GO:0046914|GO:0016568|GO:0004843|GO:0008234|GO:0006464|GO:0019941|GO:0016579|GO:0008270|GO:0006511 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|cell cycle|DNA repair|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|nucleobase-containing compound metabolic process|nuclear chromatin|regulation of protein stability|protein metabolic process|organelle organization|chromosome organization|thiol-dependent ubiquitinyl hydrolase activity|metal ion binding|histone deubiquitination|macromolecule modification|protein catabolic process|chromatin organization|cellular macromolecule catabolic process|protein modification process|mitotic cell cycle|nuclear lumen|proteolysis|DNA metabolic process|chromosome|nuclear chromosome|cellular protein metabolic process|nucleus|cellular response to DNA damage stimulus|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|protein modification by small protein removal|transition metal ion binding|chromatin modification|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|modification-dependent protein catabolic process|protein deubiquitination|zinc ion binding|ubiquitin-dependent protein catabolic process - - - - 15:63504511-63594640 40 43 71 653 555 630 0.183090141052439 0.178878246024192 0.293007737105995 2.67803275596636 2.08432770201375 2.70255194949477 0.218325374727542 2.48830413582496 -3.51061110980283 4.94817418524868e-36 1.73791520148722e-33 DOWN ENSG00000138778 CENPE centromere protein E [Source:HGNC Symbol;Acc:HGNC:1856] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0030496|GO:0051716|GO:0097159|GO:0044877|GO:0050794|GO:0019882|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0050817|GO:0051640|GO:0019884|GO:0022402|GO:0007275|GO:0051302|GO:0043168|GO:0005874|GO:0000776|GO:0001882|GO:0031325|GO:0051128|GO:0016817|GO:0022607|GO:0043231|GO:0005737|GO:0009611|GO:0006928|GO:0032403|GO:0051656|GO:0043085|GO:0005875|GO:0007154|GO:0007165|GO:0051983|GO:0051649|GO:0008092|GO:0002504|GO:0050790|GO:0007059|GO:0048002|GO:0000166|GO:0051301|GO:0007017|GO:0019538|GO:0000940|GO:0031323|GO:0050878|GO:0006996|GO:0051276|GO:0015631|GO:0032268|GO:0005829|GO:0000819|GO:0005871|GO:0035639|GO:1903047|GO:0043412|GO:0007080|GO:0051304|GO:0007596|GO:0001883|GO:0044770|GO:0008017|GO:0016818|GO:0051347|GO:0036211|GO:0000278|GO:0051233|GO:0042060|GO:0032549|GO:0007346|GO:0007599|GO:0010564|GO:0007018|GO:0051247|GO:0043515|GO:0005694|GO:0006461|GO:0051382|GO:0070925|GO:0032270|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0007067|GO:0017076|GO:0051246|GO:0008608|GO:0005856|GO:0005634|GO:0005819|GO:0000777|GO:0051303|GO:0002495|GO:0051315|GO:0051383|GO:0031401|GO:0072686|GO:0034622|GO:0007088|GO:0000793|GO:0005524|GO:0044772|GO:0043623|GO:0030554|GO:0016310|GO:0033044|GO:1990023|GO:0034508|GO:1901990|GO:0019886|GO:0015630|GO:0065004|GO:0000070|GO:0051310|GO:0051306|GO:1901987|GO:0007091|GO:0007264|GO:0006464|GO:0007079|GO:0016462|GO:0043549|GO:0033674|GO:0000775|GO:0030071|GO:0045859|GO:0045860|GO:0000779|GO:0010965|GO:0006468|GO:0017111|GO:0042325|GO:0001932|GO:0001934|GO:0042327|GO:0016887|GO:0003774|GO:0003777 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|midbody|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|antigen processing and presentation|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|coagulation|organelle localization|antigen processing and presentation of exogenous antigen|cell cycle process|multicellular organism development|regulation of cell division|anion binding|microtubule|kinetochore|nucleoside binding|positive regulation of cellular metabolic process|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|response to wounding|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|positive regulation of catalytic activity|microtubule associated complex|cell communication|signal transduction|regulation of chromosome segregation|establishment of localization in cell|cytoskeletal protein binding|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|regulation of catalytic activity|chromosome segregation|antigen processing and presentation of peptide antigen|nucleotide binding|cell division|microtubule-based process|protein metabolic process|condensed chromosome outer kinetochore|regulation of cellular metabolic process|regulation of body fluid levels|organelle organization|chromosome organization|tubulin binding|regulation of cellular protein metabolic process|cytosol|sister chromatid segregation|kinesin complex|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|mitotic metaphase plate congression|chromosome separation|blood coagulation|purine nucleoside binding|cell cycle phase transition|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|positive regulation of transferase activity|protein modification process|mitotic cell cycle|spindle midzone|wound healing|ribonucleoside binding|regulation of mitotic cell cycle|hemostasis|regulation of cell cycle process|microtubule-based movement|positive regulation of protein metabolic process|kinetochore binding|chromosome|protein complex assembly|kinetochore assembly|organelle assembly|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|purine nucleotide binding|regulation of protein metabolic process|attachment of spindle microtubules to kinetochore|cytoskeleton|nucleus|spindle|condensed chromosome kinetochore|establishment of chromosome localization|antigen processing and presentation of peptide antigen via MHC class II|attachment of mitotic spindle microtubules to kinetochore|kinetochore organization|positive regulation of protein modification process|mitotic spindle|cellular macromolecular complex assembly|regulation of mitotic nuclear division|condensed chromosome|ATP binding|mitotic cell cycle phase transition|cellular protein complex assembly|adenyl nucleotide binding|phosphorylation|regulation of chromosome organization|mitotic spindle midzone|centromere complex assembly|regulation of mitotic cell cycle phase transition|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule cytoskeleton|protein-DNA complex assembly|mitotic sister chromatid segregation|metaphase plate congression|mitotic sister chromatid separation|regulation of cell cycle phase transition|metaphase/anaphase transition of mitotic cell cycle|small GTPase mediated signal transduction|cellular protein modification process|mitotic chromosome movement towards spindle pole|pyrophosphatase activity|regulation of kinase activity|positive regulation of kinase activity|chromosome, centromeric region|regulation of mitotic metaphase/anaphase transition|regulation of protein kinase activity|positive regulation of protein kinase activity|condensed chromosome, centromeric region|regulation of mitotic sister chromatid separation|protein phosphorylation|nucleoside-triphosphatase activity|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|ATPase activity|motor activity|microtubule motor activity - - - - 4:103105806-103198409 205 216 272 1507 1800 1427 1.21837305867394 1.16669948320274 1.45749982394807 8.024845144412 8.77740778735189 7.94837888321889 1.28085745527492 8.25021060499426 -2.6873210186084 6.01890630602955e-36 2.08940033558379e-33 DOWN ENSG00000061273 HDAC7 histone deacetylase 7 [Source:HGNC Symbol;Acc:HGNC:14067] GO:0040011|GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0048870|GO:0023051|GO:0000989|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0016787|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0001818|GO:0051272|GO:0045595|GO:0003712|GO:0006725|GO:0009612|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0010632|GO:0016570|GO:0045596|GO:0030279|GO:0034641|GO:0046483|GO:2000147|GO:0022607|GO:0001817|GO:0043231|GO:0019213|GO:0043169|GO:0019899|GO:0005737|GO:0001816|GO:0071889|GO:0016810|GO:0006928|GO:0009966|GO:0009890|GO:0003682|GO:0060548|GO:0010646|GO:0006139|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0030278|GO:0009968|GO:0001503|GO:0008134|GO:0008219|GO:0010634|GO:0048869|GO:2000145|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0002040|GO:0010468|GO:0090132|GO:0034645|GO:0045216|GO:1901215|GO:0003714|GO:0046872|GO:0045668|GO:0007166|GO:0001944|GO:0043412|GO:0072358|GO:0032623|GO:0010629|GO:0051252|GO:0006325|GO:0070491|GO:0070997|GO:0016811|GO:0045667|GO:0030334|GO:0001667|GO:0036211|GO:0001649|GO:0034329|GO:0045766|GO:0031981|GO:0045765|GO:0001570|GO:0005654|GO:0033558|GO:1901214|GO:0019900|GO:0012501|GO:1901342|GO:0035556|GO:0044267|GO:0010467|GO:0000118|GO:0007399|GO:1902532|GO:0010594|GO:0071260|GO:0009059|GO:0030154|GO:0030335|GO:1902531|GO:0016070|GO:0072359|GO:0033613|GO:0016575|GO:0005634|GO:0032703|GO:0010595|GO:0030182|GO:1903672|GO:0043536|GO:0045892|GO:0038061|GO:0032774|GO:2001141|GO:0043535|GO:1902679|GO:0002042|GO:1901222|GO:0010631|GO:0016568|GO:0051402|GO:0034979|GO:0070932|GO:0007219|GO:0019901|GO:0022008|GO:0006464|GO:0004407|GO:1901223|GO:0007043|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:1903506|GO:0017136|GO:0005080|GO:0018193|GO:0043687|GO:0090049|GO:0000122|GO:0043542|GO:0090050|GO:0032446|GO:0006476|GO:0032041|GO:0018205|GO:0043534|GO:0016925 locomotion|developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|hydrolase activity|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|negative regulation of cytokine production|positive regulation of cellular component movement|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|response to mechanical stimulus|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|histone modification|negative regulation of cell differentiation|negative regulation of ossification|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell motility|cellular component assembly|regulation of cytokine production|intracellular membrane-bounded organelle|deacetylase activity|cation binding|enzyme binding|cytoplasm|cytokine production|14-3-3 protein binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|movement of cell or subcellular component|regulation of signal transduction|negative regulation of biosynthetic process|chromatin binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|regulation of ossification|negative regulation of signal transduction|ossification|transcription factor binding|cell death|positive regulation of epithelial cell migration|cellular developmental process|regulation of cell motility|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|sprouting angiogenesis|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|cell-cell junction organization|negative regulation of neuron death|transcription corepressor activity|metal ion binding|negative regulation of osteoblast differentiation|cell surface receptor signaling pathway|vasculature development|macromolecule modification|cardiovascular system development|interleukin-2 production|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|repressing transcription factor binding|neuron death|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|regulation of osteoblast differentiation|regulation of cell migration|ameboidal-type cell migration|protein modification process|osteoblast differentiation|cell junction assembly|positive regulation of angiogenesis|nuclear lumen|regulation of angiogenesis|vasculogenesis|nucleoplasm|protein deacetylase activity|regulation of neuron death|kinase binding|programmed cell death|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|gene expression|histone deacetylase complex|nervous system development|negative regulation of intracellular signal transduction|regulation of endothelial cell migration|cellular response to mechanical stimulus|macromolecule biosynthetic process|cell differentiation|positive regulation of cell migration|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|activating transcription factor binding|histone deacetylation|nucleus|negative regulation of interleukin-2 production|positive regulation of endothelial cell migration|neuron differentiation|positive regulation of sprouting angiogenesis|positive regulation of blood vessel endothelial cell migration|negative regulation of transcription, DNA-templated|NIK/NF-kappaB signaling|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of blood vessel endothelial cell migration|negative regulation of RNA biosynthetic process|cell migration involved in sprouting angiogenesis|regulation of NIK/NF-kappaB signaling|epithelial cell migration|chromatin modification|neuron apoptotic process|NAD-dependent protein deacetylase activity|histone H3 deacetylation|Notch signaling pathway|protein kinase binding|neurogenesis|cellular protein modification process|histone deacetylase activity|negative regulation of NIK/NF-kappaB signaling|cell-cell junction assembly|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|NAD-dependent histone deacetylase activity|protein kinase C binding|peptidyl-amino acid modification|post-translational protein modification|regulation of cell migration involved in sprouting angiogenesis|negative regulation of transcription from RNA polymerase II promoter|endothelial cell migration|positive regulation of cell migration involved in sprouting angiogenesis|protein modification by small protein conjugation|protein deacetylation|NAD-dependent histone deacetylase activity (H3-K14 specific)|peptidyl-lysine modification|blood vessel endothelial cell migration|protein sumoylation K11408 histone deacetylase 7[3.5.1.98] hsa05203|hsa05034 Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human) 12:47782722-47833132 104 103 146 856 995 915 0.409908165785572 0.368954284214745 0.518823680732447 3.0229091437734 3.21769529100899 3.37990041954953 0.432562043577588 3.20683495144397 -2.89017112096526 6.41730307121815e-36 2.20209386078329e-33 DOWN ENSG00000185483 ROR1 receptor tyrosine kinase-like orphan receptor 1 [Source:HGNC Symbol;Acc:HGNC:10256] GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0004872|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0005887|GO:0004888|GO:0005737|GO:0043235|GO:0031226|GO:0007154|GO:0007165|GO:0017147|GO:0000166|GO:0016021|GO:0019538|GO:0007166|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0016055|GO:0005524|GO:0030554|GO:0016310|GO:0007167|GO:0004672|GO:0004714|GO:0006464|GO:0006468|GO:0004713|GO:0018193|GO:0007169|GO:0018108 macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|integral component of plasma membrane|transmembrane signaling receptor activity|cytoplasm|receptor complex|intrinsic component of plasma membrane|cell communication|signal transduction|Wnt-protein binding|nucleotide binding|integral component of membrane|protein metabolic process|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|Wnt signaling pathway|ATP binding|adenyl nucleotide binding|phosphorylation|enzyme linked receptor protein signaling pathway|protein kinase activity|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|protein phosphorylation|protein tyrosine kinase activity|peptidyl-amino acid modification|transmembrane receptor protein tyrosine kinase signaling pathway|peptidyl-tyrosine phosphorylation - - - - 1:63774022-64181498 40 55 76 573 673 577 0.239380291017293 0.299139766413426 0.41006755118805 3.07241778668201 3.3045428911234 3.23618191387231 0.31619586953959 3.20438086389257 -3.34115520566577 8.18468041457436e-36 2.77665283064435e-33 DOWN ENSG00000174891 RSRC1 arginine/serine-rich coiled-coil 1 [Source:HGNC Symbol;Acc:HGNC:24152] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0051649|GO:0019538|GO:0009636|GO:0043412|GO:0036211|GO:0046907|GO:0031981|GO:0005654|GO:0046677|GO:0006796|GO:0044267|GO:0010467|GO:0016070|GO:0005634|GO:0051169|GO:0006396|GO:0016310|GO:0016604|GO:0016071|GO:0006464|GO:0016607|GO:0006913|GO:0006468|GO:0006397|GO:0008380|GO:0000375|GO:0000398|GO:0000380 cell|cellular process|metabolic process|response to stimulus|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|establishment of localization in cell|protein metabolic process|response to toxic substance|macromolecule modification|protein modification process|intracellular transport|nuclear lumen|nucleoplasm|response to antibiotic|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|RNA metabolic process|nucleus|nuclear transport|RNA processing|phosphorylation|nuclear body|mRNA metabolic process|cellular protein modification process|nuclear speck|nucleocytoplasmic transport|protein phosphorylation|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|alternative mRNA splicing, via spliceosome - - - - 3:158105855-158545730 69 68 88 710 690 637 0.521012783597836 0.466645659839531 0.59909640040599 4.80346568251105 4.27479791537373 4.50782542291701 0.528918281281119 4.52869634026726 -3.09797906055585 8.66697851990787e-36 2.90723569363292e-33 DOWN ENSG00000170310 STX8 syntaxin 8 [Source:HGNC Symbol;Acc:HGNC:11443] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0016247|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0060341|GO:0031201|GO:0006810|GO:0031982|GO:0051128|GO:0005887|GO:0043231|GO:0019899|GO:0005774|GO:0005737|GO:0032880|GO:0022406|GO:0005484|GO:0045184|GO:0000149|GO:0031226|GO:0008104|GO:0061024|GO:0005783|GO:0051649|GO:0010008|GO:0016021|GO:0017081|GO:0016248|GO:0010256|GO:0005794|GO:0005768|GO:0006996|GO:0061025|GO:0016192|GO:0048278|GO:0005802|GO:0016050|GO:0005769|GO:0015031|GO:0005773|GO:0007009|GO:0008200|GO:0046907|GO:0019869|GO:0055037|GO:0005770|GO:0072657|GO:0048471|GO:0034613|GO:1903827|GO:0019905|GO:0031902|GO:0048284|GO:0044389|GO:0031625|GO:0000323|GO:0072659|GO:0045022|GO:0016482|GO:0006886|GO:0006906|GO:0016197|GO:1903076|GO:0007034|GO:1990778|GO:0005765|GO:0008333|GO:0007041|GO:0005764 macromolecular complex|cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|channel regulator activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of cellular localization|SNARE complex|transport|vesicle|regulation of cellular component organization|integral component of plasma membrane|intracellular membrane-bounded organelle|enzyme binding|vacuolar membrane|cytoplasm|regulation of protein localization|membrane docking|SNAP receptor activity|establishment of protein localization|SNARE binding|intrinsic component of plasma membrane|protein localization|membrane organization|endoplasmic reticulum|establishment of localization in cell|endosome membrane|integral component of membrane|chloride channel regulator activity|channel inhibitor activity|endomembrane system organization|Golgi apparatus|endosome|organelle organization|membrane fusion|vesicle-mediated transport|vesicle docking|trans-Golgi network|vesicle organization|early endosome|protein transport|vacuole|plasma membrane organization|ion channel inhibitor activity|intracellular transport|chloride channel inhibitor activity|recycling endosome|late endosome|protein localization to membrane|perinuclear region of cytoplasm|cellular protein localization|regulation of cellular protein localization|syntaxin binding|late endosome membrane|organelle fusion|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|lytic vacuole|protein localization to plasma membrane|early endosome to late endosome transport|cytosolic transport|intracellular protein transport|vesicle fusion|endosomal transport|regulation of protein localization to plasma membrane|vacuolar transport|protein localization to cell periphery|lysosomal membrane|endosome to lysosome transport|lysosomal transport|lysosome K08501 syntaxin 8[-] hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) 17:9250471-9576591 19 20 18 313 311 276 0.260308120567419 0.249030804102535 0.222352302138455 3.84224939467612 3.49600532984245 3.54390718129255 0.243897075602803 3.62738730193704 -3.89458642737113 3.60577569145426e-35 1.19607586102973e-32 DOWN ENSG00000139734 DIAPH3 diaphanous related formin 3 [Source:HGNC Symbol;Acc:HGNC:15480] GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0044702|GO:0019953|GO:0016043|GO:0043227|GO:0032504|GO:0005622|GO:0005515|GO:0048609|GO:0043231|GO:0019899|GO:0005737|GO:0007154|GO:0007276|GO:0007165|GO:0008092|GO:0030029|GO:0006996|GO:0005829|GO:0048232|GO:0007010|GO:0003779|GO:0030036|GO:0035556|GO:0051020|GO:0005634|GO:0007283|GO:0031267|GO:0007264|GO:0017016|GO:0017048 reproduction|signaling|cell|cellular process|reproductive process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|single organism reproductive process|sexual reproduction|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|intracellular|protein binding|multicellular organismal reproductive process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|cell communication|gamete generation|signal transduction|cytoskeletal protein binding|actin filament-based process|organelle organization|cytosol|male gamete generation|cytoskeleton organization|actin binding|actin cytoskeleton organization|intracellular signal transduction|GTPase binding|nucleus|spermatogenesis|small GTPase binding|small GTPase mediated signal transduction|Ras GTPase binding|Rho GTPase binding K05745 diaphanous 3[-] hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) 13:59665583-60163987 62 74 79 703 779 565 0.524289263076261 0.568710143915259 0.602315120766259 5.32638763952442 5.40486856126348 4.4777251357666 0.565104842585926 5.06966044551817 -3.16529866466244 4.00366905555631e-35 1.31346742840196e-32 DOWN ENSG00000044446 PHKA2 phosphorylase kinase, alpha 2 (liver) [Source:HGNC Symbol;Acc:HGNC:8926] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0009056|GO:0044237|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0044262|GO:0015980|GO:0044281|GO:0016772|GO:0005737|GO:0005975|GO:0005516|GO:0006091|GO:0019538|GO:0055114|GO:0005829|GO:0005976|GO:0043412|GO:0005964|GO:0044275|GO:0036211|GO:1990234|GO:0005977|GO:0005996|GO:0016052|GO:0016301|GO:0006112|GO:0006796|GO:0044267|GO:0016773|GO:0019318|GO:0005980|GO:0016310|GO:0004672|GO:0006464|GO:0000272|GO:1902911|GO:0006468|GO:0006006|GO:0004674|GO:1902554|GO:0004683|GO:0004689 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|catabolic process|cellular metabolic process|cell periphery|intracellular|protein binding|plasma membrane|protein complex|transferase activity|cellular carbohydrate metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|cytoplasm|carbohydrate metabolic process|calmodulin binding|generation of precursor metabolites and energy|protein metabolic process|oxidation-reduction process|cytosol|polysaccharide metabolic process|macromolecule modification|phosphorylase kinase complex|cellular carbohydrate catabolic process|protein modification process|transferase complex|glycogen metabolic process|monosaccharide metabolic process|carbohydrate catabolic process|kinase activity|energy reserve metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|phosphotransferase activity, alcohol group as acceptor|hexose metabolic process|glycogen catabolic process|phosphorylation|protein kinase activity|cellular protein modification process|polysaccharide catabolic process|protein kinase complex|protein phosphorylation|glucose metabolic process|protein serine/threonine kinase activity|serine/threonine protein kinase complex|calmodulin-dependent protein kinase activity|phosphorylase kinase activity K07190 phosphorylase kinase alpha/beta subunit[-] hsa04020|hsa04910|hsa04922 Calcium signaling pathway - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human) X:18892300-18984598 43 33 76 626 678 631 0.257903074371998 0.17988056581882 0.410971549520328 3.36400434538117 3.33643351435496 3.54684785254111 0.282918396570382 3.41576190409241 -3.5937495201802 1.45113785169699e-34 4.70894232875674e-32 DOWN ENSG00000089177 KIF16B kinesin family member 16B [Source:HGNC Symbol;Acc:HGNC:15869] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0043227|GO:0008289|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0009888|GO:0006810|GO:0007275|GO:0043168|GO:0005874|GO:0005543|GO:0001882|GO:0016817|GO:0043231|GO:0019899|GO:0001881|GO:0005737|GO:0006928|GO:0032403|GO:0048598|GO:0005875|GO:0007154|GO:0001704|GO:0007165|GO:0051649|GO:0008092|GO:0001919|GO:0010008|GO:0000166|GO:0007017|GO:0010033|GO:0031323|GO:0005768|GO:0071774|GO:0016192|GO:0015631|GO:0032801|GO:0005871|GO:0007166|GO:0035639|GO:0005769|GO:0035091|GO:0001883|GO:0007492|GO:0009790|GO:0008017|GO:0016818|GO:0007369|GO:0046907|GO:0032549|GO:0044344|GO:0007018|GO:0070848|GO:0031901|GO:0071310|GO:0017076|GO:0051020|GO:0005856|GO:0043112|GO:0008543|GO:0005524|GO:0071363|GO:0030554|GO:0045022|GO:0048193|GO:0016482|GO:0007167|GO:0015630|GO:0016197|GO:1901981|GO:0031267|GO:0030705|GO:0016462|GO:0017016|GO:1902936|GO:0017111|GO:0032266|GO:0005547|GO:0006892|GO:0006895|GO:0007169|GO:0017137|GO:0016887|GO:0080025|GO:0003774|GO:0038127|GO:0043325|GO:0007173|GO:0003777|GO:0008574 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|lipid binding|hydrolase activity|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|tissue development|transport|multicellular organism development|anion binding|microtubule|phospholipid binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|enzyme binding|receptor recycling|cytoplasm|movement of cell or subcellular component|protein complex binding|embryonic morphogenesis|microtubule associated complex|cell communication|formation of primary germ layer|signal transduction|establishment of localization in cell|cytoskeletal protein binding|regulation of receptor recycling|endosome membrane|nucleotide binding|microtubule-based process|response to organic substance|regulation of cellular metabolic process|endosome|response to fibroblast growth factor|vesicle-mediated transport|tubulin binding|receptor catabolic process|kinesin complex|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|early endosome|phosphatidylinositol binding|purine nucleoside binding|endoderm development|embryo development|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|gastrulation|intracellular transport|ribonucleoside binding|cellular response to fibroblast growth factor stimulus|microtubule-based movement|response to growth factor|early endosome membrane|cellular response to organic substance|purine nucleotide binding|GTPase binding|cytoskeleton|receptor metabolic process|fibroblast growth factor receptor signaling pathway|ATP binding|cellular response to growth factor stimulus|adenyl nucleotide binding|early endosome to late endosome transport|Golgi vesicle transport|cytosolic transport|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|endosomal transport|phosphatidylinositol phosphate binding|small GTPase binding|cytoskeleton-dependent intracellular transport|pyrophosphatase activity|Ras GTPase binding|phosphatidylinositol bisphosphate binding|nucleoside-triphosphatase activity|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|post-Golgi vesicle-mediated transport|Golgi to endosome transport|transmembrane receptor protein tyrosine kinase signaling pathway|Rab GTPase binding|ATPase activity|phosphatidylinositol-3,5-bisphosphate binding|motor activity|ERBB signaling pathway|phosphatidylinositol-3,4-bisphosphate binding|epidermal growth factor receptor signaling pathway|microtubule motor activity|ATP-dependent microtubule motor activity, plus-end-directed - - - - 20:16272104-16573433 51 47 104 775 817 811 0.515000337291743 0.431339560652982 0.946854698443539 7.01192373388862 6.76905042421006 7.67516189998115 0.631064865462755 7.15204535269328 -3.50249567630595 1.48414251119469e-34 4.76425704615121e-32 DOWN ENSG00000184349 EFNA5 ephrin-A5 [Source:HGNC Symbol;Acc:HGNC:3225] GO:0040011|GO:0032502|GO:0040007|GO:0004871|GO:0045499|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0016049|GO:0044089|GO:0071704|GO:0009986|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0030297|GO:0016043|GO:0045927|GO:0007155|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0031224|GO:0030234|GO:0050793|GO:0048589|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0031225|GO:0060341|GO:0016337|GO:0006935|GO:0045595|GO:0009897|GO:0048468|GO:0006810|GO:0051130|GO:0061178|GO:0044853|GO:0007275|GO:0032535|GO:0005102|GO:0030307|GO:0008047|GO:0032940|GO:0030155|GO:0046658|GO:0031325|GO:0051128|GO:0022607|GO:0098609|GO:0050803|GO:0045597|GO:0032970|GO:0007267|GO:0032886|GO:0032880|GO:0006928|GO:0051963|GO:0042592|GO:1901888|GO:0031589|GO:0045184|GO:0046883|GO:0019725|GO:0048639|GO:0010646|GO:0031226|GO:0043085|GO:0008104|GO:0007154|GO:0007165|GO:0048588|GO:0051965|GO:0048638|GO:0050808|GO:0051649|GO:0030546|GO:0050790|GO:0030030|GO:0019207|GO:0010817|GO:0048869|GO:0016021|GO:0030029|GO:0007017|GO:0019538|GO:0010033|GO:0098857|GO:0001558|GO:0031323|GO:0006996|GO:0060560|GO:0005901|GO:0032268|GO:0000902|GO:0031175|GO:0048668|GO:0009743|GO:0031344|GO:0048672|GO:0005126|GO:0045216|GO:0007416|GO:0007166|GO:0032956|GO:0090276|GO:0048670|GO:0043412|GO:0007010|GO:0050807|GO:0010720|GO:0031362|GO:0019887|GO:0070507|GO:0048878|GO:0051223|GO:0015031|GO:0031346|GO:0000904|GO:0050919|GO:0051347|GO:0036211|GO:0070201|GO:0007160|GO:0042886|GO:0055082|GO:0034329|GO:0022407|GO:0051046|GO:0050769|GO:0008361|GO:0009914|GO:0009306|GO:0010810|GO:0051247|GO:0022604|GO:0046875|GO:0006461|GO:0030036|GO:0035773|GO:0032270|GO:0006796|GO:0033043|GO:0044267|GO:0051174|GO:0032990|GO:0019209|GO:0007399|GO:0046903|GO:0071310|GO:0097485|GO:0051246|GO:0010770|GO:0030154|GO:0048858|GO:0031233|GO:0045121|GO:0000226|GO:0051960|GO:0048666|GO:0030182|GO:0050796|GO:0071322|GO:0002790|GO:0007411|GO:0030073|GO:0010975|GO:0031401|GO:0001678|GO:0034622|GO:0010769|GO:0034332|GO:0043623|GO:0034284|GO:0050708|GO:0043087|GO:0016310|GO:0015833|GO:0061564|GO:0051493|GO:0007167|GO:0001952|GO:0007044|GO:0030295|GO:0048041|GO:0050772|GO:0022008|GO:0048667|GO:0051893|GO:0006464|GO:0050767|GO:0048812|GO:0046879|GO:0010976|GO:0043549|GO:0033500|GO:0034333|GO:0033674|GO:0045666|GO:0071333|GO:0042593|GO:0030072|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0042325|GO:0001932|GO:0018193|GO:0001934|GO:0007171|GO:0030296|GO:0031290|GO:0050770|GO:0045664|GO:0042327|GO:0007169|GO:0005169|GO:0050731|GO:0050730|GO:0048013|GO:0005170|GO:0009749|GO:0005168|GO:0032147|GO:0018108 locomotion|developmental process|growth|signal transducer activity|chemorepellent activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|cell growth|positive regulation of cellular component biogenesis|organic substance metabolic process|cell surface|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|transmembrane receptor protein tyrosine kinase activator activity|cellular component organization|positive regulation of growth|cell adhesion|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|enzyme regulator activity|regulation of developmental process|developmental growth|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|anchored component of membrane|regulation of cellular localization|single organismal cell-cell adhesion|chemotaxis|regulation of cell differentiation|external side of plasma membrane|cell development|transport|positive regulation of cellular component organization|regulation of insulin secretion involved in cellular response to glucose stimulus|plasma membrane raft|multicellular organism development|regulation of cellular component size|receptor binding|positive regulation of cell growth|enzyme activator activity|secretion by cell|regulation of cell adhesion|anchored component of plasma membrane|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|cell-cell adhesion|regulation of synapse structure or activity|positive regulation of cell differentiation|regulation of actin filament-based process|cell-cell signaling|regulation of microtubule-based process|regulation of protein localization|movement of cell or subcellular component|regulation of synapse assembly|homeostatic process|regulation of cell junction assembly|cell-substrate adhesion|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|positive regulation of developmental growth|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|cell communication|signal transduction|developmental cell growth|positive regulation of synapse assembly|regulation of developmental growth|synapse organization|establishment of localization in cell|receptor activator activity|regulation of catalytic activity|cell projection organization|kinase regulator activity|regulation of hormone levels|cellular developmental process|integral component of membrane|actin filament-based process|microtubule-based process|protein metabolic process|response to organic substance|membrane microdomain|regulation of cell growth|regulation of cellular metabolic process|organelle organization|developmental growth involved in morphogenesis|caveola|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|collateral sprouting|response to carbohydrate|regulation of cell projection organization|positive regulation of collateral sprouting|cytokine receptor binding|cell-cell junction organization|synapse assembly|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|regulation of peptide hormone secretion|regulation of collateral sprouting|macromolecule modification|cytoskeleton organization|regulation of synapse organization|positive regulation of cell development|anchored component of external side of plasma membrane|protein kinase regulator activity|regulation of microtubule cytoskeleton organization|chemical homeostasis|regulation of protein transport|protein transport|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|negative chemotaxis|positive regulation of transferase activity|protein modification process|regulation of establishment of protein localization|cell-matrix adhesion|amide transport|cellular chemical homeostasis|cell junction assembly|regulation of cell-cell adhesion|regulation of secretion|positive regulation of neurogenesis|regulation of cell size|hormone transport|protein secretion|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|regulation of cell morphogenesis|ephrin receptor binding|protein complex assembly|actin cytoskeleton organization|insulin secretion involved in cellular response to glucose stimulus|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|kinase activator activity|nervous system development|secretion|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|cell projection morphogenesis|intrinsic component of external side of plasma membrane|membrane raft|microtubule cytoskeleton organization|regulation of nervous system development|neuron development|neuron differentiation|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|axon guidance|insulin secretion|regulation of neuron projection development|positive regulation of protein modification process|cellular glucose homeostasis|cellular macromolecular complex assembly|regulation of cell morphogenesis involved in differentiation|adherens junction organization|cellular protein complex assembly|response to monosaccharide|regulation of protein secretion|regulation of GTPase activity|phosphorylation|peptide transport|axon development|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|cell-substrate junction assembly|protein kinase activator activity|focal adhesion assembly|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of focal adhesion assembly|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|hormone secretion|positive regulation of neuron projection development|regulation of kinase activity|carbohydrate homeostasis|adherens junction assembly|positive regulation of kinase activity|positive regulation of neuron differentiation|cellular response to glucose stimulus|glucose homeostasis|peptide hormone secretion|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|activation of transmembrane receptor protein tyrosine kinase activity|protein tyrosine kinase activator activity|retinal ganglion cell axon guidance|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|neurotrophin TRKB receptor binding|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|ephrin receptor signaling pathway|neurotrophin TRKC receptor binding|response to glucose|neurotrophin TRKA receptor binding|activation of protein kinase activity|peptidyl-tyrosine phosphorylation K05462 ephrin-A[-] hsa04151|hsa04014|hsa04015|hsa04360 PI3K-Akt signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Axon guidance - Homo sapiens (human) 5:107376889-107670895 18 16 23 286 289 352 0.173069239366028 0.139811993103862 0.199383148259826 2.46381441666906 2.27987054550241 3.17188311492098 0.170754793576572 2.63852269236415 -3.94973240656406 3.3148948263484e-34 1.05279649091282e-31 DOWN ENSG00000075420 FNDC3B fibronectin type III domain containing 3B [Source:HGNC Symbol;Acc:HGNC:24670] GO:0016020|GO:0005488|GO:0097159|GO:0031224|GO:0005515|GO:0003676|GO:0016021|GO:0003723|GO:0044822 membrane|binding|organic cyclic compound binding|intrinsic component of membrane|protein binding|nucleic acid binding|integral component of membrane|RNA binding|poly(A) RNA binding - - - - 3:172039628-172401665 107 108 227 1555 1660 2243 0.44161594437672 0.405101150857081 0.844696346771014 5.7502726947726 5.62129312703126 8.67597956829909 0.563804480668272 6.68251513003432 -3.56712435045477 4.70579677632618e-34 1.4634047600046e-31 DOWN ENSG00000235437 LINC01278 long intergenic non-protein coding RNA 1278 [Source:HGNC Symbol;Acc:HGNC:28090] - - - - - - X:63343227-63561071 270 241 513 3173 3203 3417 1.57335228505974 1.2763217913925 2.69522253232493 16.5664948389584 15.3139675730953 18.6610767119264 1.84829886959239 16.8471797079934 -3.18823713386638 4.69034256732454e-34 1.4634047600046e-31 DOWN ENSG00000186376 ZNF75D zinc finger protein 75D [Source:HGNC Symbol;Acc:HGNC:13145] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0008270 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|zinc ion binding - - - - X:135248920-135344087 39 43 51 420 466 473 0.247351237012623 0.247860164445249 0.291632792011278 2.38671751456128 2.42497818193963 2.81154007905345 0.26228139782305 2.54107859185145 -3.27625360261312 4.79109049024775e-34 1.47456923191605e-31 DOWN ENSG00000135341 MAP3K7 mitogen-activated protein kinase kinase kinase 7 [Source:HGNC Symbol;Acc:HGNC:6859] GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0005057|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0002757|GO:0002250|GO:0016337|GO:0045087|GO:0006725|GO:0050867|GO:1901360|GO:0016570|GO:0070489|GO:0034641|GO:0043168|GO:0006952|GO:0030155|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0001817|GO:0098609|GO:0043231|GO:0043169|GO:0005737|GO:0002218|GO:0001816|GO:0097110|GO:0002696|GO:0001775|GO:0009966|GO:0002367|GO:0001819|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0050778|GO:0045785|GO:0004702|GO:0008219|GO:0010008|GO:0050790|GO:0000166|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0005768|GO:0002443|GO:0006996|GO:0051090|GO:0000165|GO:0002369|GO:0051276|GO:1902533|GO:0051249|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0002758|GO:0034097|GO:0032623|GO:0051252|GO:0006325|GO:0001883|GO:0034109|GO:0016573|GO:0010628|GO:0051347|GO:0002718|GO:0036211|GO:0032549|GO:0051251|GO:0051091|GO:0002720|GO:0002429|GO:0032743|GO:0022407|GO:0031981|GO:0031098|GO:1990234|GO:0007159|GO:0051247|GO:0005654|GO:0002764|GO:0016301|GO:0002821|GO:0002460|GO:0032270|GO:0042110|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0017076|GO:0002819|GO:0031328|GO:0000123|GO:0051246|GO:0009059|GO:0022409|GO:1902531|GO:0016070|GO:0004709|GO:0016773|GO:0010557|GO:0005634|GO:0045089|GO:0030522|GO:0045088|GO:0070304|GO:0045893|GO:0002456|GO:0019221|GO:0031401|GO:0050863|GO:0043122|GO:0008385|GO:0043408|GO:0038061|GO:0000287|GO:0032774|GO:0005524|GO:0002726|GO:2001141|GO:0043966|GO:0030554|GO:0016310|GO:0051092|GO:0002768|GO:0034112|GO:0035872|GO:0002221|GO:0070486|GO:0043123|GO:0007249|GO:1901222|GO:0043410|GO:0032872|GO:0005671|GO:0071345|GO:0004672|GO:0016568|GO:0002724|GO:0034612|GO:0006464|GO:0050870|GO:0050851|GO:0051403|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:1901224|GO:1903039|GO:0033674|GO:0000186|GO:0002223|GO:0045859|GO:0045860|GO:0002224|GO:0043406|GO:0046328|GO:0002711|GO:1902911|GO:0006468|GO:0071356|GO:1903506|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0007250|GO:0070423|GO:0018193|GO:0038093|GO:0004674|GO:0033209|GO:0007252|GO:0032874|GO:0001934|GO:0050852|GO:0071593|GO:0042327|GO:0046330|GO:0034166|GO:0034134|GO:1902554|GO:0038124|GO:0043507|GO:0000187|GO:0038095|GO:0002756|GO:0071902|GO:0034138|GO:0002755|GO:0034146|GO:0071900|GO:0043506|GO:0034142|GO:0006473|GO:0038123|GO:0018205|GO:0034162|GO:0032147|GO:0018394|GO:0035666|GO:0006475|GO:0018393 macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|receptor signaling protein activity|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|immune response-activating signal transduction|adaptive immune response|single organismal cell-cell adhesion|innate immune response|cellular aromatic compound metabolic process|positive regulation of cell activation|organic cyclic compound metabolic process|histone modification|T cell aggregation|cellular nitrogen compound metabolic process|anion binding|defense response|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|regulation of cytokine production|cell-cell adhesion|intracellular membrane-bounded organelle|cation binding|cytoplasm|activation of innate immune response|cytokine production|scaffold protein binding|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|cytokine production involved in immune response|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|positive regulation of immune response|positive regulation of cell adhesion|receptor signaling protein serine/threonine kinase activity|cell death|endosome membrane|regulation of catalytic activity|nucleotide binding|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|endosome|leukocyte mediated immunity|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|MAPK cascade|T cell cytokine production|chromosome organization|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|response to cytokine|interleukin-2 production|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|homotypic cell-cell adhesion|histone acetylation|positive regulation of gene expression|positive regulation of transferase activity|regulation of cytokine production involved in immune response|protein modification process|ribonucleoside binding|positive regulation of lymphocyte activation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cytokine production involved in immune response|immune response-activating cell surface receptor signaling pathway|positive regulation of interleukin-2 production|regulation of cell-cell adhesion|nuclear lumen|stress-activated protein kinase signaling cascade|transferase complex|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|nucleoplasm|immune response-regulating signaling pathway|kinase activity|positive regulation of adaptive immune response|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|purine nucleotide binding|regulation of adaptive immune response|positive regulation of cellular biosynthetic process|histone acetyltransferase complex|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of cell-cell adhesion|regulation of intracellular signal transduction|RNA metabolic process|MAP kinase kinase kinase activity|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of innate immune response|intracellular receptor signaling pathway|regulation of innate immune response|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|T cell mediated immunity|cytokine-mediated signaling pathway|positive regulation of protein modification process|regulation of T cell activation|regulation of I-kappaB kinase/NF-kappaB signaling|IkappaB kinase complex|regulation of MAPK cascade|NIK/NF-kappaB signaling|magnesium ion binding|RNA biosynthetic process|ATP binding|positive regulation of T cell cytokine production|regulation of RNA biosynthetic process|histone H3 acetylation|adenyl nucleotide binding|phosphorylation|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|positive regulation of homotypic cell-cell adhesion|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|pattern recognition receptor signaling pathway|leukocyte aggregation|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|regulation of NIK/NF-kappaB signaling|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|Ada2/Gcn5/Ada3 transcription activator complex|cellular response to cytokine stimulus|protein kinase activity|chromatin modification|regulation of T cell cytokine production|response to tumor necrosis factor|cellular protein modification process|positive regulation of T cell activation|antigen receptor-mediated signaling pathway|stress-activated MAPK cascade|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of NIK/NF-kappaB signaling|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|activation of MAPKK activity|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|regulation of JNK cascade|positive regulation of T cell mediated immunity|protein kinase complex|protein phosphorylation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|activation of NF-kappaB-inducing kinase activity|nucleotide-binding oligomerization domain containing signaling pathway|peptidyl-amino acid modification|Fc receptor signaling pathway|protein serine/threonine kinase activity|tumor necrosis factor-mediated signaling pathway|I-kappaB phosphorylation|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|T cell receptor signaling pathway|lymphocyte aggregation|positive regulation of phosphorylation|positive regulation of JNK cascade|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|serine/threonine protein kinase complex|toll-like receptor TLR6:TLR2 signaling pathway|positive regulation of JUN kinase activity|activation of MAPK activity|Fc-epsilon receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|toll-like receptor 4 signaling pathway|protein acetylation|toll-like receptor TLR1:TLR2 signaling pathway|peptidyl-lysine modification|toll-like receptor 9 signaling pathway|activation of protein kinase activity|peptidyl-lysine acetylation|TRIF-dependent toll-like receptor signaling pathway|internal protein amino acid acetylation|internal peptidyl-lysine acetylation K04427 mitogen-activated protein kinase kinase kinase 7[2.7.11.25] hsa04010|hsa05169|hsa05168|hsa04310|hsa05162|hsa04380|hsa04152|hsa05145|hsa04668|hsa04620|hsa04660|hsa04064|hsa04520|hsa05140|hsa04622|hsa04621 MAPK signaling pathway - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Measles - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|RIG-I-like receptor signaling pathway - Homo sapiens (human)|NOD-like receptor signaling pathway - Homo sapiens (human) 6:90513573-90587045 63 100 162 1079 1295 1060 0.454507534834833 0.655658358787042 1.05372538807268 6.97457050140204 7.66542050066616 7.16692551699963 0.721297093898185 7.26897217302261 -3.33308586628903 4.85388723165826e-34 1.47865254504006e-31 DOWN ENSG00000160294 MCM3AP minichromosome maintenance complex component 3 associated protein [Source:HGNC Symbol;Acc:HGNC:6946] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0009058|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0016746|GO:0005737|GO:0005635|GO:0045184|GO:0006139|GO:0008104|GO:0051649|GO:0006403|GO:0031965|GO:0000166|GO:0044249|GO:0005829|GO:0003677|GO:0034645|GO:0072594|GO:0015031|GO:0046907|GO:0031981|GO:0005654|GO:0006259|GO:0034613|GO:0050658|GO:0017038|GO:0009059|GO:0005634|GO:0006606|GO:0005643|GO:0033365|GO:0006260|GO:0051028|GO:0051169|GO:0006605|GO:0006886|GO:0006913|GO:0034504|GO:0051170 immune system process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|biosynthetic process|intracellular|endomembrane system|transferase activity|organelle membrane|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|nuclear envelope|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|establishment of localization in cell|RNA localization|nuclear membrane|nucleotide binding|cellular biosynthetic process|cytosol|DNA binding|cellular macromolecule biosynthetic process|establishment of protein localization to organelle|protein transport|intracellular transport|nuclear lumen|nucleoplasm|DNA metabolic process|cellular protein localization|RNA transport|protein import|macromolecule biosynthetic process|nucleus|protein import into nucleus|nuclear pore|protein localization to organelle|DNA replication|mRNA transport|nuclear transport|protein targeting|intracellular protein transport|nucleocytoplasmic transport|protein localization to nucleus|nuclear import - - - - 21:46235126-46286297 156 151 184 1139 1309 983 0.925286425247772 0.81397057174219 0.98397013463245 6.05302588346747 6.37028211195028 5.4642853973959 0.907742377207471 5.96253113093788 -2.71557007846862 5.00645292778861e-34 1.50972369400203e-31 DOWN ENSG00000106070 GRB10 growth factor receptor bound protein 10 [Source:HGNC Symbol;Acc:HGNC:4564] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0071704|GO:0051051|GO:0044237|GO:0023051|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0035591|GO:0044262|GO:0006810|GO:0005102|GO:0015980|GO:0044281|GO:0031325|GO:0090287|GO:1900076|GO:0010243|GO:0005737|GO:0005975|GO:0032403|GO:0009966|GO:0009890|GO:0030674|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0010829|GO:0006091|GO:0009967|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0055114|GO:0030111|GO:0006109|GO:0005829|GO:0005976|GO:0034645|GO:0030178|GO:0007166|GO:0030949|GO:0030947|GO:1901652|GO:0071417|GO:0005158|GO:0033692|GO:0043434|GO:0005977|GO:0005996|GO:0070848|GO:0006112|GO:0043467|GO:0006796|GO:0051174|GO:0071310|GO:0046627|GO:0009059|GO:0046626|GO:0008643|GO:0005070|GO:0046325|GO:0032870|GO:0016051|GO:0010827|GO:0005978|GO:0016055|GO:0019318|GO:1901653|GO:0000271|GO:0071363|GO:0046324|GO:0016310|GO:0010906|GO:0007167|GO:0071375|GO:0045719|GO:0032868|GO:0070873|GO:0005979|GO:0008645|GO:0006006|GO:0042325|GO:0032869|GO:0042326|GO:0042327|GO:0007169|GO:0048010|GO:0048009|GO:0015758|GO:0008286|GO:0046323 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|binding, bridging|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|organic substance metabolic process|negative regulation of transport|cellular metabolic process|regulation of signaling|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|signaling adaptor activity|cellular carbohydrate metabolic process|transport|receptor binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|positive regulation of cellular metabolic process|regulation of cellular response to growth factor stimulus|regulation of cellular response to insulin stimulus|response to organonitrogen compound|cytoplasm|carbohydrate metabolic process|protein complex binding|regulation of signal transduction|negative regulation of biosynthetic process|protein binding, bridging|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|negative regulation of glucose transport|generation of precursor metabolites and energy|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|oxidation-reduction process|regulation of Wnt signaling pathway|regulation of carbohydrate metabolic process|cytosol|polysaccharide metabolic process|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|regulation of vascular endothelial growth factor receptor signaling pathway|response to peptide|cellular response to organonitrogen compound|insulin receptor binding|cellular polysaccharide biosynthetic process|response to peptide hormone|glycogen metabolic process|monosaccharide metabolic process|response to growth factor|energy reserve metabolic process|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|negative regulation of insulin receptor signaling pathway|macromolecule biosynthetic process|regulation of insulin receptor signaling pathway|carbohydrate transport|SH3/SH2 adaptor activity|negative regulation of glucose import|cellular response to hormone stimulus|carbohydrate biosynthetic process|regulation of glucose transport|glycogen biosynthetic process|Wnt signaling pathway|hexose metabolic process|cellular response to peptide|polysaccharide biosynthetic process|cellular response to growth factor stimulus|regulation of glucose import|phosphorylation|regulation of glucose metabolic process|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|negative regulation of glycogen biosynthetic process|response to insulin|regulation of glycogen metabolic process|regulation of glycogen biosynthetic process|hexose transport|glucose metabolic process|regulation of phosphorylation|cellular response to insulin stimulus|negative regulation of phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|insulin-like growth factor receptor signaling pathway|glucose transport|insulin receptor signaling pathway|glucose import - - - - 7:50590063-50793462 90 91 118 721 873 735 0.350875535115214 0.322430275234413 0.414771268218198 2.51851983208403 2.79251234865194 2.68552457065188 0.362692359522608 2.66551891712928 -2.87759816197251 5.92532438376238e-34 1.76894634152842e-31 DOWN ENSG00000172379 ARNT2 aryl hydrocarbon receptor nuclear translocator 2 [Source:HGNC Symbol;Acc:HGNC:16876] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:1901360|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0007420|GO:0043231|GO:0005737|GO:0000981|GO:0060322|GO:0005667|GO:0046983|GO:0060548|GO:0006139|GO:0008134|GO:0009725|GO:0008219|GO:0001666|GO:0044249|GO:0010033|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0033993|GO:0007417|GO:0043069|GO:0046982|GO:0051252|GO:0009790|GO:0010628|GO:0017162|GO:0012501|GO:0014070|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0043067|GO:0048545|GO:0097305|GO:0000975|GO:0045893|GO:0009792|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0043627|GO:0003690|GO:0032355|GO:0042981|GO:0043066|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0043009|GO:0000976|GO:0001012|GO:0001701|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|transcription factor complex|protein dimerization activity|negative regulation of cell death|nucleobase-containing compound metabolic process|transcription factor binding|response to hormone|cell death|response to hypoxia|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|central nervous system development|negative regulation of programmed cell death|protein heterodimerization activity|regulation of RNA metabolic process|embryo development|positive regulation of gene expression|aryl hydrocarbon receptor binding|programmed cell death|response to organic cyclic compound|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|response to steroid hormone|response to alcohol|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|response to estrogen|double-stranded DNA binding|response to estradiol|regulation of apoptotic process|negative regulation of apoptotic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K15589 aryl hydrocarbon receptor nuclear translocator 2[-] hsa05200|hsa05202|hsa05211 Pathways in cancer - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human) 15:80404350-80597937 1730 1880 2391 396 429 396 8.31745818948758 8.21452528081274 10.364259552579 1.70583729324747 1.69227024972028 1.78430431977471 8.96541434095977 1.72747062091415 2.37570908457 2.21466865534805e-33 6.54620970660998e-31 UP ENSG00000089154 GCN1 GCN1, eIF2 alpha kinase activator homolog [Source:HGNC Symbol;Acc:HGNC:4199] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0009991|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0005737|GO:0030529|GO:0031668|GO:0006139|GO:0007154|GO:0044249|GO:0019538|GO:0031323|GO:0042594|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0043620|GO:0051252|GO:0005840|GO:0010628|GO:0005844|GO:0009267|GO:0043603|GO:0044267|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0031669|GO:0016070|GO:0031667|GO:0010557|GO:0045893|GO:0043043|GO:0032774|GO:2001141|GO:0010608|GO:0006412|GO:0006417|GO:0034198|GO:0044822|GO:0008135|GO:0006351|GO:0006355|GO:0043618|GO:0045944|GO:0006366|GO:1990253|GO:0006357|GO:1903506|GO:0036003 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|response to extracellular stimulus|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cytoplasm|intracellular ribonucleoprotein complex|cellular response to extracellular stimulus|nucleobase-containing compound metabolic process|cell communication|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|response to starvation|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|regulation of DNA-templated transcription in response to stress|regulation of RNA metabolic process|ribosome|positive regulation of gene expression|polysome|cellular response to starvation|cellular amide metabolic process|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cellular response to nutrient levels|RNA metabolic process|response to nutrient levels|positive regulation of macromolecule biosynthetic process|positive regulation of transcription, DNA-templated|peptide biosynthetic process|RNA biosynthetic process|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|translation|regulation of translation|cellular response to amino acid starvation|poly(A) RNA binding|translation factor activity, RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cellular response to leucine starvation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|positive regulation of transcription from RNA polymerase II promoter in response to stress - - - - 12:120127203-120194710 598 590 589 3491 4128 3451 3.73482769481455 3.34889361433575 3.31664354361072 19.5351480380325 21.1532356937229 20.1996121857601 3.46678828425367 20.2959986391718 -2.54952368840366 2.50771108294236e-33 7.33972614413347e-31 DOWN ENSG00000198791 CNOT7 CCR4-NOT transcription complex subunit 7 [Source:HGNC Symbol;Acc:HGNC:14101] GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0030014|GO:0005737|GO:0030529|GO:0005975|GO:0030015|GO:0009890|GO:0016458|GO:0006139|GO:0007154|GO:0007165|GO:0008285|GO:0044249|GO:0022613|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0035770|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0003723|GO:0031047|GO:0010629|GO:0051252|GO:0044265|GO:0010628|GO:0032269|GO:0022618|GO:0031981|GO:0004518|GO:0005654|GO:0070925|GO:0043603|GO:0044267|GO:0010467|GO:0031328|GO:0019439|GO:0051246|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0036464|GO:0016441|GO:0006401|GO:0045893|GO:0043043|GO:0090501|GO:0034622|GO:0006396|GO:0050684|GO:0032774|GO:0017148|GO:2001141|GO:0010608|GO:0006412|GO:0004527|GO:0040029|GO:0016071|GO:0006417|GO:0004540|GO:0090305|GO:0033962|GO:0061014|GO:0006351|GO:0035194|GO:0006355|GO:0000932|GO:0031442|GO:0004532|GO:0045944|GO:0006366|GO:0006357|GO:0008408|GO:1903506|GO:0006402|GO:0031440|GO:0006397|GO:0090503|GO:0035195|GO:1900153|GO:0031123|GO:0000956|GO:0031124|GO:0000175|GO:0016896|GO:0060213|GO:0000291|GO:0000289|GO:0004535|GO:0000290|GO:0000288|GO:0043928 macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|CCR4-NOT complex|cytoplasm|intracellular ribonucleoprotein complex|carbohydrate metabolic process|CCR4-NOT core complex|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of cell proliferation|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|ribonucleoprotein granule|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|RNA binding|gene silencing by RNA|negative regulation of gene expression|regulation of RNA metabolic process|cellular macromolecule catabolic process|positive regulation of gene expression|negative regulation of cellular protein metabolic process|ribonucleoprotein complex assembly|nuclear lumen|nuclease activity|nucleoplasm|organelle assembly|cellular amide metabolic process|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|cytoplasmic ribonucleoprotein granule|posttranscriptional gene silencing|RNA catabolic process|positive regulation of transcription, DNA-templated|peptide biosynthetic process|RNA phosphodiester bond hydrolysis|cellular macromolecular complex assembly|RNA processing|regulation of mRNA processing|RNA biosynthetic process|negative regulation of translation|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|translation|exonuclease activity|regulation of gene expression, epigenetic|mRNA metabolic process|regulation of translation|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|cytoplasmic mRNA processing body assembly|positive regulation of mRNA catabolic process|transcription, DNA-templated|posttranscriptional gene silencing by RNA|regulation of transcription, DNA-templated|cytoplasmic mRNA processing body|positive regulation of mRNA 3'-end processing|exoribonuclease activity|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|3'-5' exonuclease activity|regulation of nucleic acid-templated transcription|mRNA catabolic process|regulation of mRNA 3'-end processing|mRNA processing|RNA phosphodiester bond hydrolysis, exonucleolytic|gene silencing by miRNA|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|RNA 3'-end processing|nuclear-transcribed mRNA catabolic process|mRNA 3'-end processing|3'-5'-exoribonuclease activity|exoribonuclease activity, producing 5'-phosphomonoesters|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, exonucleolytic|nuclear-transcribed mRNA poly(A) tail shortening|poly(A)-specific ribonuclease activity|deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay K12581 CCR4-NOT transcription complex subunit 7/8[-] hsa03018 RNA degradation - Homo sapiens (human) 8:17224964-17246878 311 322 397 2104 2363 1881 1.63356093573827 1.53712863068689 1.88009597782244 9.90189541916812 10.1837217737627 9.2596080622319 1.68359518141587 9.78174175172091 -2.53854609082188 3.44561306507877e-33 9.98692548008366e-31 DOWN ENSG00000136770 DNAJC1 DnaJ heat shock protein family (Hsp40) member C1 [Source:HGNC Symbol;Acc:HGNC:20090] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0006457|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0030234|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:0006810|GO:0003676|GO:0034641|GO:0008047|GO:0032940|GO:0043231|GO:0051087|GO:0005737|GO:0032880|GO:0005635|GO:0045184|GO:0043085|GO:0008104|GO:0005783|GO:0031965|GO:0050790|GO:0016021|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0006518|GO:0051345|GO:0051223|GO:0015031|GO:0032269|GO:0070201|GO:0051046|GO:0009306|GO:0006508|GO:0043603|GO:0044267|GO:0010467|GO:0046903|GO:0051246|GO:0009059|GO:0060590|GO:0005634|GO:0001671|GO:0032781|GO:0043043|GO:0030162|GO:0050708|GO:0010608|GO:0006412|GO:0006417|GO:0045861|GO:0043462 cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|protein folding|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|transport|nucleic acid binding|cellular nitrogen compound metabolic process|enzyme activator activity|secretion by cell|intracellular membrane-bounded organelle|chaperone binding|cytoplasm|regulation of protein localization|nuclear envelope|establishment of protein localization|positive regulation of catalytic activity|protein localization|endoplasmic reticulum|nuclear membrane|regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|positive regulation of hydrolase activity|regulation of protein transport|protein transport|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|regulation of secretion|protein secretion|proteolysis|cellular amide metabolic process|cellular protein metabolic process|gene expression|secretion|regulation of protein metabolic process|macromolecule biosynthetic process|ATPase regulator activity|nucleus|ATPase activator activity|positive regulation of ATPase activity|peptide biosynthetic process|regulation of proteolysis|regulation of protein secretion|posttranscriptional regulation of gene expression|translation|regulation of translation|negative regulation of proteolysis|regulation of ATPase activity K09521 DnaJ homolog subfamily C member 1[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 10:21756537-22003769 21 17 36 351 366 330 0.379148599626037 0.278947054620227 0.585998755367011 5.67788205859124 5.42163300733577 5.58372795505682 0.414698136537758 5.56108100699461 -3.74523188313956 1.0209594987573e-32 2.93074277652889e-30 DOWN ENSG00000008083 JARID2 jumonji and AT-rich interaction domain containing 2 [Source:HGNC Symbol;Acc:HGNC:6196] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0032259|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042127|GO:0006725|GO:0051130|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0000981|GO:0031519|GO:0009890|GO:0003682|GO:0006139|GO:0008285|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0048732|GO:0006996|GO:0051276|GO:0032268|GO:0003677|GO:0048538|GO:0010468|GO:0034645|GO:0043412|GO:0007417|GO:0010629|GO:0031056|GO:0051252|GO:0048536|GO:0016571|GO:0006479|GO:0006325|GO:0001889|GO:0031058|GO:0036211|GO:0032269|GO:0031981|GO:1990234|GO:0051247|GO:0005654|GO:0032270|GO:0033043|GO:0044267|GO:0010467|GO:0007399|GO:0001227|GO:0051246|GO:0009059|GO:0030154|GO:0035097|GO:0016070|GO:0005634|GO:0035098|GO:0061647|GO:0010638|GO:2001252|GO:0031062|GO:0045814|GO:0000975|GO:0048863|GO:0031401|GO:2001251|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0033044|GO:1902679|GO:0003690|GO:0040029|GO:0031061|GO:0031060|GO:0051567|GO:0018022|GO:0034968|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0051574|GO:0006357|GO:1903506|GO:0044212|GO:0018193|GO:0000122|GO:0051570|GO:0000976|GO:0001012|GO:0018205|GO:0000977 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|methylation|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|PcG protein complex|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|negative regulation of cell proliferation|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|organelle organization|chromosome organization|regulation of cellular protein metabolic process|DNA binding|thymus development|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|central nervous system development|negative regulation of gene expression|regulation of histone modification|regulation of RNA metabolic process|spleen development|histone methylation|protein methylation|chromatin organization|liver development|positive regulation of histone modification|protein modification process|negative regulation of cellular protein metabolic process|nuclear lumen|transferase complex|positive regulation of protein metabolic process|nucleoplasm|positive regulation of cellular protein metabolic process|regulation of organelle organization|cellular protein metabolic process|gene expression|nervous system development|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|histone methyltransferase complex|RNA metabolic process|nucleus|ESC/E(Z) complex|histone H3-K9 modification|positive regulation of organelle organization|positive regulation of chromosome organization|positive regulation of histone methylation|negative regulation of gene expression, epigenetic|regulatory region DNA binding|stem cell differentiation|positive regulation of protein modification process|negative regulation of chromosome organization|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of chromosome organization|negative regulation of RNA biosynthetic process|double-stranded DNA binding|regulation of gene expression, epigenetic|negative regulation of histone methylation|regulation of histone methylation|histone H3-K9 methylation|peptidyl-lysine methylation|histone lysine methylation|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|positive regulation of histone H3-K9 methylation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|peptidyl-amino acid modification|negative regulation of transcription from RNA polymerase II promoter|regulation of histone H3-K9 methylation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|peptidyl-lysine modification|RNA polymerase II regulatory region sequence-specific DNA binding K11478 protein Jumonji[-] hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) 6:15246296-15522040 69 67 140 840 981 984 0.604514213121691 0.533475311364321 1.10586165896441 6.59377271238592 7.05170187387305 8.07943440608387 0.747950394483474 7.24163633078095 -3.27530123156193 1.20384940694549e-32 3.42283049475722e-30 DOWN ENSG00000156052 GNAQ guanine nucleotide binding protein (G protein), q polypeptide [Source:HGNC Symbol;Acc:HGNC:4390] GO:0032502|GO:0004871|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042752|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0051606|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0007623|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0051641|GO:0044297|GO:0009653|GO:0043473|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0032504|GO:0016787|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0005929|GO:0031090|GO:0048609|GO:0019222|GO:0007507|GO:0060341|GO:0050817|GO:0042391|GO:0009791|GO:0045595|GO:0009888|GO:0048468|GO:0009314|GO:0006810|GO:0007275|GO:0048513|GO:0005102|GO:0043168|GO:0008047|GO:0030900|GO:0048066|GO:0001882|GO:0031982|GO:0016817|GO:0007420|GO:0009582|GO:0043231|GO:0043169|GO:0005774|GO:0005737|GO:0009611|GO:0060322|GO:0032880|GO:0005635|GO:0032403|GO:0001775|GO:0043005|GO:0048598|GO:0045184|GO:0072372|GO:0036477|GO:0043085|GO:0008104|GO:0007154|GO:0044092|GO:0001750|GO:0007165|GO:0070062|GO:0031647|GO:0051649|GO:0031965|GO:0050790|GO:0000166|GO:0043086|GO:0048869|GO:0048070|GO:0019538|GO:0031324|GO:0031323|GO:0050878|GO:0009649|GO:0032268|GO:0007186|GO:0042711|GO:0030168|GO:0005096|GO:0046872|GO:0042733|GO:0007166|GO:0035639|GO:0043412|GO:0072594|GO:0009583|GO:0072358|GO:0007417|GO:0051345|GO:0050821|GO:0007596|GO:0030695|GO:0032386|GO:0001883|GO:0051223|GO:0015031|GO:0005773|GO:0009790|GO:0001508|GO:0016818|GO:0031683|GO:0036211|GO:0032269|GO:0030856|GO:0070201|GO:0042060|GO:0046907|GO:0032549|GO:0007602|GO:0007599|GO:0030425|GO:0001664|GO:0034613|GO:0021872|GO:0050931|GO:0060429|GO:0006796|GO:0035108|GO:0044267|GO:0051174|GO:0017038|GO:0007399|GO:0017076|GO:0051246|GO:0030154|GO:0001501|GO:0060173|GO:0048469|GO:1903827|GO:0072359|GO:0005634|GO:0009416|GO:0006606|GO:0031513|GO:0048666|GO:0045634|GO:0030182|GO:1904589|GO:0021953|GO:0032561|GO:0042551|GO:0007200|GO:0033365|GO:0033157|GO:0007187|GO:0007215|GO:0051169|GO:0030855|GO:0000323|GO:0031821|GO:0043087|GO:0016310|GO:0006605|GO:0007213|GO:0016482|GO:0006886|GO:0043547|GO:0009584|GO:0021954|GO:0033673|GO:0030318|GO:0005525|GO:0007603|GO:0042306|GO:0021879|GO:1900180|GO:0022008|GO:0006464|GO:0019001|GO:0030326|GO:0016462|GO:0035411|GO:0060193|GO:0043549|GO:0005765|GO:0007212|GO:1903533|GO:0031826|GO:0006913|GO:0045859|GO:0007188|GO:0006469|GO:0010517|GO:0005764|GO:0006468|GO:0048699|GO:0035412|GO:0017111|GO:0042325|GO:0016322|GO:0001932|GO:0042326|GO:0021884|GO:0010518|GO:0001933|GO:0034504|GO:0046822|GO:0060158|GO:0010863|GO:0051170|GO:0007189|GO:0060563|GO:0003924|GO:0007202 developmental process|signal transducer activity|reproduction|behavior|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|regulation of circadian rhythm|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|detection of stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|circadian rhythm|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular localization|cell body|anatomical structure morphogenesis|pigmentation|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|cilium|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|heart development|regulation of cellular localization|coagulation|regulation of membrane potential|post-embryonic development|regulation of cell differentiation|tissue development|cell development|response to radiation|transport|multicellular organism development|animal organ development|receptor binding|anion binding|enzyme activator activity|forebrain development|developmental pigmentation|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|brain development|detection of abiotic stimulus|intracellular membrane-bounded organelle|cation binding|vacuolar membrane|cytoplasm|response to wounding|head development|regulation of protein localization|nuclear envelope|protein complex binding|cell activation|neuron projection|embryonic morphogenesis|establishment of protein localization|primary cilium|somatodendritic compartment|positive regulation of catalytic activity|protein localization|cell communication|negative regulation of molecular function|photoreceptor outer segment|signal transduction|extracellular exosome|regulation of protein stability|establishment of localization in cell|nuclear membrane|regulation of catalytic activity|nucleotide binding|negative regulation of catalytic activity|cellular developmental process|regulation of developmental pigmentation|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|entrainment of circadian clock|regulation of cellular protein metabolic process|G-protein coupled receptor signaling pathway|maternal behavior|platelet activation|GTPase activator activity|metal ion binding|embryonic digit morphogenesis|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|establishment of protein localization to organelle|detection of light stimulus|cardiovascular system development|central nervous system development|positive regulation of hydrolase activity|protein stabilization|blood coagulation|GTPase regulator activity|regulation of intracellular transport|purine nucleoside binding|regulation of protein transport|protein transport|vacuole|embryo development|action potential|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|G-protein beta/gamma-subunit complex binding|protein modification process|negative regulation of cellular protein metabolic process|regulation of epithelial cell differentiation|regulation of establishment of protein localization|wound healing|intracellular transport|ribonucleoside binding|phototransduction|hemostasis|dendrite|G-protein coupled receptor binding|cellular protein localization|forebrain generation of neurons|pigment cell differentiation|epithelium development|phosphate-containing compound metabolic process|limb morphogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|protein import|nervous system development|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|skeletal system development|limb development|cell maturation|regulation of cellular protein localization|circulatory system development|nucleus|response to light stimulus|protein import into nucleus|nonmotile primary cilium|neuron development|regulation of melanocyte differentiation|neuron differentiation|regulation of protein import|central nervous system neuron differentiation|guanyl ribonucleotide binding|neuron maturation|phospholipase C-activating G-protein coupled receptor signaling pathway|protein localization to organelle|regulation of intracellular protein transport|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|glutamate receptor signaling pathway|nuclear transport|epithelial cell differentiation|lytic vacuole|G-protein coupled serotonin receptor binding|regulation of GTPase activity|phosphorylation|protein targeting|G-protein coupled acetylcholine receptor signaling pathway|cytosolic transport|intracellular protein transport|positive regulation of GTPase activity|detection of visible light|central nervous system neuron development|negative regulation of kinase activity|melanocyte differentiation|GTP binding|phototransduction, visible light|regulation of protein import into nucleus|forebrain neuron differentiation|regulation of protein localization to nucleus|neurogenesis|cellular protein modification process|guanyl nucleotide binding|embryonic limb morphogenesis|pyrophosphatase activity|catenin import into nucleus|positive regulation of lipase activity|regulation of kinase activity|lysosomal membrane|dopamine receptor signaling pathway|regulation of protein targeting|type 2A serotonin receptor binding|nucleocytoplasmic transport|regulation of protein kinase activity|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|negative regulation of protein kinase activity|regulation of phospholipase activity|lysosome|protein phosphorylation|generation of neurons|regulation of catenin import into nucleus|nucleoside-triphosphatase activity|regulation of phosphorylation|neuron remodeling|regulation of protein phosphorylation|negative regulation of phosphorylation|forebrain neuron development|positive regulation of phospholipase activity|negative regulation of protein phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|phospholipase C-activating dopamine receptor signaling pathway|positive regulation of phospholipase C activity|nuclear import|adenylate cyclase-activating G-protein coupled receptor signaling pathway|neuroepithelial cell differentiation|GTPase activity|activation of phospholipase C activity K04634 guanine nucleotide-binding protein G(q) subunit alpha[-] hsa05200|hsa04015|hsa05016|hsa04020|hsa05010|hsa04022|hsa04921|hsa04261|hsa04728|hsa04611|hsa04270|hsa04071|hsa04724|hsa04726|hsa04725|hsa05142|hsa04922|hsa04723|hsa04916|hsa04915|hsa04750|hsa05146|hsa04972|hsa04713|hsa04912|hsa04970|hsa04540|hsa04911|hsa04925|hsa04971|hsa04918|hsa04720|hsa04924|hsa04730|hsa04961 Pathways in cancer - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Renin secretion - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) 9:77716087-78031458 82 99 181 1035 1116 1191 0.859321067488167 0.94288493784974 1.71015215463901 9.71806968440865 9.5956452763408 11.6972245343213 1.17078605332564 10.3369798316903 -3.14226536284861 1.46397147388967e-32 4.12315135674549e-30 DOWN ENSG00000124532 MRS2 MRS2, magnesium transporter [Source:HGNC Symbol;Acc:HGNC:13785] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0051641|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0006810|GO:0043231|GO:0005737|GO:0031966|GO:0022891|GO:0055085|GO:0051649|GO:0016021|GO:0005740|GO:0046907|GO:0006811|GO:0015075|GO:0005743|GO:0005739|GO:1903830|GO:0006839|GO:0006812|GO:0008324|GO:0045016|GO:0022890|GO:0030001|GO:0046873|GO:0015095|GO:0015693 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|cellular localization|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|transport|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|substrate-specific transmembrane transporter activity|transmembrane transport|establishment of localization in cell|integral component of membrane|mitochondrial envelope|intracellular transport|ion transport|ion transmembrane transporter activity|mitochondrial inner membrane|mitochondrion|magnesium ion transmembrane transport|mitochondrial transport|cation transport|cation transmembrane transporter activity|mitochondrial magnesium ion transport|inorganic cation transmembrane transporter activity|metal ion transport|metal ion transmembrane transporter activity|magnesium ion transmembrane transporter activity|magnesium ion transport - - - - 6:24402908-24426194 108 148 161 1048 1139 841 0.950311743145455 1.18354530510042 1.27727736686563 8.26233230433402 8.22309723053255 6.93535178765402 1.13704480503717 7.80692710750686 -2.77946569496084 1.50311166179404e-32 4.15499032881474e-30 DOWN ENSG00000148498 PARD3 par-3 family cell polarity regulator [Source:HGNC Symbol;Acc:HGNC:16051] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0005911|GO:0044297|GO:0009653|GO:0016043|GO:0030427|GO:0008289|GO:0071944|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0019222|GO:0060341|GO:0007049|GO:0048468|GO:0043025|GO:0006810|GO:0031643|GO:0031641|GO:0005938|GO:0007275|GO:0050877|GO:0043168|GO:0005543|GO:0030426|GO:0022607|GO:0019899|GO:0005737|GO:0071559|GO:0043005|GO:0045184|GO:0036477|GO:0008104|GO:0007163|GO:0007154|GO:0061024|GO:0007165|GO:0051649|GO:0030030|GO:0051301|GO:0048869|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0043296|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007186|GO:0045216|GO:0090150|GO:0007166|GO:0030424|GO:0043412|GO:0021782|GO:0035091|GO:0044295|GO:0015031|GO:0000904|GO:0036211|GO:0032269|GO:0071560|GO:0046907|GO:0044304|GO:0034329|GO:0019902|GO:0072657|GO:0030010|GO:0031644|GO:0070848|GO:0006461|GO:0034613|GO:0006796|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0008356|GO:0051246|GO:0030154|GO:0048858|GO:0005923|GO:0033269|GO:0051960|GO:0008366|GO:0007422|GO:0048666|GO:0030182|GO:0014044|GO:0010001|GO:0071363|GO:0016310|GO:0006605|GO:0007179|GO:0061564|GO:0019903|GO:0006886|GO:0007167|GO:1901981|GO:0042552|GO:0022008|GO:0048667|GO:0006464|GO:0090162|GO:0048812|GO:0007043|GO:0006612|GO:0014037|GO:0007205|GO:0070830|GO:0043297|GO:0007409|GO:0006468|GO:1902936|GO:0048699|GO:0042325|GO:0001932|GO:0018193|GO:0022011|GO:0042326|GO:0032266|GO:0042063|GO:0005547|GO:0007178|GO:0001933|GO:0010801|GO:0018107|GO:0005546 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell-cell junction|cell body|anatomical structure morphogenesis|cellular component organization|site of polarized growth|lipid binding|cell periphery|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cellular localization|cell cycle|cell development|neuronal cell body|transport|positive regulation of myelination|regulation of myelination|cell cortex|multicellular organism development|neurological system process|anion binding|phospholipid binding|growth cone|cellular component assembly|enzyme binding|cytoplasm|response to transforming growth factor beta|neuron projection|establishment of protein localization|somatodendritic compartment|protein localization|establishment or maintenance of cell polarity|cell communication|membrane organization|signal transduction|establishment of localization in cell|cell projection organization|cell division|cellular developmental process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|apical junction complex|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|cell-cell junction organization|establishment of protein localization to membrane|cell surface receptor signaling pathway|axon|macromolecule modification|glial cell development|phosphatidylinositol binding|axonal growth cone|protein transport|cell morphogenesis involved in differentiation|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|intracellular transport|main axon|cell junction assembly|phosphatase binding|protein localization to membrane|establishment of cell polarity|regulation of neurological system process|response to growth factor|protein complex assembly|cellular protein localization|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|asymmetric cell division|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|bicellular tight junction|internode region of axon|regulation of nervous system development|axon ensheathment|peripheral nervous system development|neuron development|neuron differentiation|Schwann cell development|glial cell differentiation|cellular response to growth factor stimulus|phosphorylation|protein targeting|transforming growth factor beta receptor signaling pathway|axon development|protein phosphatase binding|intracellular protein transport|enzyme linked receptor protein signaling pathway|phosphatidylinositol phosphate binding|myelination|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|establishment of epithelial cell polarity|neuron projection morphogenesis|cell-cell junction assembly|protein targeting to membrane|Schwann cell differentiation|protein kinase C-activating G-protein coupled receptor signaling pathway|bicellular tight junction assembly|apical junction assembly|axonogenesis|protein phosphorylation|phosphatidylinositol bisphosphate binding|generation of neurons|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|myelination in peripheral nervous system|negative regulation of phosphorylation|phosphatidylinositol-3-phosphate binding|gliogenesis|phosphatidylinositol-3,4,5-trisphosphate binding|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|negative regulation of peptidyl-threonine phosphorylation|peptidyl-threonine phosphorylation|phosphatidylinositol-4,5-bisphosphate binding K04237 partitioning defective protein 3[-] hsa04080|hsa04144|hsa04015|hsa04062|hsa04390|hsa04530|hsa04520 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Adherens junction - Homo sapiens (human) 10:34109560-34815325 93 99 183 981 1158 1066 0.674097707598052 0.652164497436802 1.19593023340575 6.37099421717526 6.88679321544855 7.24146835569199 0.840730812813535 6.83308526277193 -3.02282127476902 1.49623584155603e-32 4.15499032881474e-30 DOWN ENSG00000197622 CDC42SE1 CDC42 small effector 1 [Source:HGNC Symbol;Acc:HGNC:17719] GO:0032502|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0009892|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0071944|GO:0030234|GO:0050793|GO:0005622|GO:0005886|GO:0048856|GO:0019222|GO:0004857|GO:0008360|GO:0006810|GO:0051128|GO:0005737|GO:0007154|GO:0044092|GO:0007165|GO:0050790|GO:0043086|GO:0048869|GO:0016192|GO:0000902|GO:0006909|GO:0030695|GO:0005095|GO:0051346|GO:0022604|GO:0005856|GO:0043087|GO:0006897|GO:0034260 developmental process|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|cell periphery|enzyme regulator activity|regulation of developmental process|intracellular|plasma membrane|anatomical structure development|regulation of metabolic process|enzyme inhibitor activity|regulation of cell shape|transport|regulation of cellular component organization|cytoplasm|cell communication|negative regulation of molecular function|signal transduction|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|vesicle-mediated transport|cell morphogenesis|phagocytosis|GTPase regulator activity|GTPase inhibitor activity|negative regulation of hydrolase activity|regulation of cell morphogenesis|cytoskeleton|regulation of GTPase activity|endocytosis|negative regulation of GTPase activity - - - - 1:151050971-151070325 134 124 232 1133 1511 1594 0.987988457546008 0.830896962456183 1.54222509621796 7.48468851058912 9.14068166372743 11.0144606296809 1.12037017207338 9.21327693466582 -3.03973889876037 1.74739816850402e-32 4.78594724059808e-30 DOWN ENSG00000110721 CHKA choline kinase alpha [Source:HGNC Symbol;Acc:HGNC:1937] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0008144|GO:0044237|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0042802|GO:0044255|GO:0006810|GO:0033265|GO:0034641|GO:0043168|GO:0016788|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0043178|GO:0043169|GO:0005737|GO:0046983|GO:0007154|GO:0006629|GO:0007165|GO:0000166|GO:0044249|GO:0010876|GO:0010033|GO:0009636|GO:0005829|GO:0008654|GO:0046486|GO:0035639|GO:0006066|GO:0009308|GO:0001883|GO:0006580|GO:0046470|GO:0032549|GO:0006869|GO:0016301|GO:0014070|GO:0006796|GO:0008610|GO:0019695|GO:0017076|GO:0016773|GO:0052689|GO:0042803|GO:0006644|GO:0004103|GO:0004305|GO:0006656|GO:0046474|GO:0005524|GO:0030554|GO:0016310|GO:0006576|GO:0004104|GO:0006650|GO:1904681|GO:0006646|GO:0046337|GO:0006657 signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|drug binding|cellular metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|transferase activity|identical protein binding|cellular lipid metabolic process|transport|choline binding|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|alcohol binding|cation binding|cytoplasm|protein dimerization activity|cell communication|lipid metabolic process|signal transduction|nucleotide binding|cellular biosynthetic process|lipid localization|response to organic substance|response to toxic substance|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|alcohol metabolic process|amine metabolic process|purine nucleoside binding|ethanolamine metabolic process|phosphatidylcholine metabolic process|ribonucleoside binding|lipid transport|kinase activity|response to organic cyclic compound|phosphate-containing compound metabolic process|lipid biosynthetic process|choline metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|carboxylic ester hydrolase activity|protein homodimerization activity|phospholipid metabolic process|choline kinase activity|ethanolamine kinase activity|phosphatidylcholine biosynthetic process|glycerophospholipid biosynthetic process|ATP binding|adenyl nucleotide binding|phosphorylation|cellular biogenic amine metabolic process|cholinesterase activity|glycerophospholipid metabolic process|response to 3-methylcholanthrene|phosphatidylethanolamine biosynthetic process|phosphatidylethanolamine metabolic process|CDP-choline pathway K14156 choline/ethanolamine kinase[2.7.1.82] hsa01100|hsa05231|hsa00564 Metabolic pathways - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human) 11:68052859-68121444 130 171 260 1273 1477 1333 1.52753500813203 1.82610615949813 2.75446728056862 13.4021761369582 14.2395953227273 14.6793969631746 2.03603614939959 14.1070561409534 -2.79258187638364 1.98049691547238e-32 5.37506862859204e-30 DOWN ENSG00000112699 GMDS GDP-mannose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:4369] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0006807|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0009058|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0031982|GO:0046483|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0070062|GO:0050662|GO:0000166|GO:0044249|GO:0007166|GO:0009225|GO:0050661|GO:0016836|GO:1901137|GO:0070401|GO:0046368|GO:0007219|GO:0019673|GO:0008446|GO:0042351 signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|biosynthetic process|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|vesicle|heterocycle metabolic process|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|extracellular exosome|coenzyme binding|nucleotide binding|cellular biosynthetic process|cell surface receptor signaling pathway|nucleotide-sugar metabolic process|NADP binding|hydro-lyase activity|carbohydrate derivative biosynthetic process|NADP+ binding|GDP-L-fucose metabolic process|Notch signaling pathway|GDP-mannose metabolic process|GDP-mannose 4,6-dehydratase activity|'de novo' GDP-L-fucose biosynthetic process K01711 GDPmannose 4,6-dehydratase[4.2.1.47] hsa01100|hsa00520|hsa00051 Metabolic pathways - Homo sapiens (human)|Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)|Fructose and mannose metabolism - Homo sapiens (human) 6:1623806-2245692 36 29 58 464 600 442 0.475988932342381 0.348478913074932 0.691413134103859 5.49677641801694 6.50895011611921 5.47700305195744 0.505293659840391 5.82757652869786 -3.52770206218621 3.39845213240936e-32 9.14030540188729e-30 DOWN ENSG00000106780 MEGF9 multiple EGF-like-domains 9 [Source:HGNC Symbol;Acc:HGNC:3234] GO:0031012|GO:0016020|GO:0005576|GO:0005488|GO:0005604|GO:0005578|GO:0031224|GO:0005515|GO:0016021 extracellular matrix|membrane|extracellular region|binding|basement membrane|proteinaceous extracellular matrix|intrinsic component of membrane|protein binding|integral component of membrane - - - - 9:120600813-120714470 395 508 687 3119 3552 3854 4.43649562607633 5.18545733653272 6.9568678351146 31.3874631701764 32.7328584428476 40.568013306948 5.52627359924122 34.8961116399907 -2.65868739543424 5.37664115210837e-32 1.43316290138431e-29 DOWN ENSG00000151136 BTBD11 BTB (POZ) domain containing 11 [Source:HGNC Symbol;Acc:HGNC:23844] GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0031224|GO:0005515|GO:0046983|GO:0007154|GO:0007165|GO:0016021|GO:0007166|GO:0046982|GO:0060395|GO:0007167|GO:0007178 signaling|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intrinsic component of membrane|protein binding|protein dimerization activity|cell communication|signal transduction|integral component of membrane|cell surface receptor signaling pathway|protein heterodimerization activity|SMAD protein signal transduction|enzyme linked receptor protein signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway - - - - 12:107318413-107659642 21 27 37 326 390 305 0.129534723869447 0.151359223996577 0.205768621355209 1.80166137508682 1.97374384123445 1.76314012410346 0.162220856407078 1.84618178014158 -3.5085133907307 1.16699817451427e-31 3.08314721256187e-29 DOWN ENSG00000138780 GSTCD glutathione S-transferase, C-terminal domain containing [Source:HGNC Symbol;Acc:HGNC:25806] GO:0005623|GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0005622|GO:0005515|GO:0031982|GO:0005737|GO:0070062 cell|extracellular region|binding|extracellular vesicle|membrane-bounded organelle|intracellular|protein binding|vesicle|cytoplasm|extracellular exosome - - - - 4:105708778-105847728 48 67 77 586 586 506 0.290225108420354 0.368175028973034 0.419763217472975 3.17462152862332 2.9071157075947 2.86732354612783 0.359387784955454 2.98302026078195 -3.05316049676129 1.32806999655562e-31 3.47791242782207e-29 DOWN ENSG00000123352 SPATS2 spermatogenesis associated, serine rich 2 [Source:HGNC Symbol;Acc:HGNC:18650] GO:0005623|GO:0005488|GO:0097159|GO:0005622|GO:0005515|GO:0003676|GO:0005737|GO:0003723|GO:0044822 cell|binding|organic cyclic compound binding|intracellular|protein binding|nucleic acid binding|cytoplasm|RNA binding|poly(A) RNA binding - - - - 12:49366584-49527424 76 68 127 739 875 754 0.409694850469146 0.333145598336894 0.617251865900361 3.56933997715712 3.87009696599303 3.80930711824304 0.453364104902134 3.74958135379773 -3.04798745025471 1.54402762046135e-31 4.00829570271766e-29 DOWN ENSG00000105983 LMBR1 limb development membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:13243] GO:0032502|GO:0016020|GO:0009653|GO:0031224|GO:0048856|GO:0007275|GO:0048598|GO:0016021|GO:0042733|GO:0009790|GO:0035108|GO:0060173|GO:0030326 developmental process|membrane|anatomical structure morphogenesis|intrinsic component of membrane|anatomical structure development|multicellular organism development|embryonic morphogenesis|integral component of membrane|embryonic digit morphogenesis|embryo development|limb morphogenesis|limb development|embryonic limb morphogenesis - - - - 7:156668946-156893230 143 161 242 1605 1149 1496 0.393978440455865 0.403127013023878 0.60112514481333 3.96194111429894 2.59730782577211 3.86274416942113 0.466076866097691 3.47399770316406 -2.89795698915964 1.73853759883287e-31 4.43609414320997e-29 DOWN ENSG00000148634 HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 [Source:HGNC Symbol;Acc:HGNC:24521] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0003824|GO:0044702|GO:0071704|GO:0009056|GO:0019953|GO:0044237|GO:0032504|GO:0016874|GO:0005622|GO:0016740|GO:0048609|GO:0005737|GO:0007276|GO:0019787|GO:0048869|GO:0019538|GO:0005829|GO:0048232|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:0006508|GO:0044267|GO:0030154|GO:0007283|GO:0044257|GO:0051603|GO:0006464|GO:0019941|GO:0032446|GO:0006511|GO:0042787|GO:0016567 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|catalytic activity|single organism reproductive process|organic substance metabolic process|catabolic process|sexual reproduction|cellular metabolic process|multicellular organism reproduction|ligase activity|intracellular|transferase activity|multicellular organismal reproductive process|cytoplasm|gamete generation|ubiquitin-like protein transferase activity|cellular developmental process|protein metabolic process|cytosol|male gamete generation|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|proteolysis|cellular protein metabolic process|cell differentiation|spermatogenesis|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|cellular protein modification process|modification-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination K10615 E3 ubiquitin-protein ligase HERC4[2.3.2.26] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 10:67921899-68075348 283 266 541 2949 3048 2909 0.973286615037424 0.831409099233396 1.67750996827336 9.08711681707843 8.60075584522598 9.37618730791374 1.16073522751473 9.02135332340605 -2.95830495314697 1.73672202509177e-31 4.43609414320997e-29 DOWN ENSG00000168397 ATG4B autophagy related 4B, cysteine peptidase [Source:HGNC Symbol;Acc:HGNC:20790] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0010506|GO:0006810|GO:0031325|GO:0022607|GO:0008233|GO:0005737|GO:0010508|GO:0045184|GO:0008104|GO:0061024|GO:0000422|GO:0051649|GO:0044804|GO:0016236|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0005829|GO:0045732|GO:0034645|GO:0090150|GO:1903008|GO:0043412|GO:0030163|GO:0007005|GO:0051604|GO:0015031|GO:0036211|GO:0046907|GO:0042157|GO:0072657|GO:0051247|GO:0006508|GO:0034613|GO:0070925|GO:0044267|GO:0042176|GO:0010467|GO:0051246|GO:0009059|GO:0000045|GO:0007033|GO:0016485|GO:0006605|GO:0006886|GO:0004175|GO:0042158|GO:0008234|GO:0006464|GO:0006612|GO:0051697|GO:0004197|GO:0043687|GO:0006497|GO:0006501 cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of autophagy|transport|positive regulation of cellular metabolic process|cellular component assembly|peptidase activity|cytoplasm|positive regulation of autophagy|establishment of protein localization|protein localization|membrane organization|mitophagy|establishment of localization in cell|nucleophagy|macroautophagy|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|cytosol|positive regulation of protein catabolic process|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|organelle disassembly|macromolecule modification|protein catabolic process|mitochondrion organization|protein maturation|protein transport|protein modification process|intracellular transport|lipoprotein metabolic process|protein localization to membrane|positive regulation of protein metabolic process|proteolysis|cellular protein localization|organelle assembly|cellular protein metabolic process|regulation of protein catabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|autophagosome assembly|vacuole organization|protein processing|protein targeting|intracellular protein transport|endopeptidase activity|lipoprotein biosynthetic process|cysteine-type peptidase activity|cellular protein modification process|protein targeting to membrane|protein delipidation|cysteine-type endopeptidase activity|post-translational protein modification|protein lipidation|C-terminal protein lipidation K08342 cysteine protease ATG4 [EC:3.4.22.-][-] hsa04140 Regulation of autophagy - Homo sapiens (human) 2:241637213-241673857 177 158 209 1042 1202 1162 0.726494363461231 0.589381091359695 0.773427280455354 3.83199514209703 4.04792228720229 4.46986752487603 0.696434245092093 4.11659498472512 -2.56339246455756 1.84353944907845e-31 4.66415480616847e-29 DOWN ENSG00000183840 GPR39 G protein-coupled receptor 39 [Source:HGNC Symbol;Acc:HGNC:4496] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0043167|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0005887|GO:0043169|GO:0004888|GO:0031226|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0046872|GO:0004930 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|ion binding|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|integral component of plasma membrane|cation binding|transmembrane signaling receptor activity|intrinsic component of plasma membrane|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|metal ion binding|G-protein coupled receptor activity - - - - 2:132416574-132646559 12 4 27 363 413 357 0.149002811361572 0.0451376528552357 0.302259791071511 4.03834439505537 4.20743678992934 4.15428695863827 0.165466751762773 4.13335604787433 -4.64270038121206 3.51796147622357e-31 8.82564890009904e-29 DOWN ENSG00000198286 CARD11 caspase recruitment domain family member 11 [Source:HGNC Symbol;Acc:HGNC:16393] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0008283|GO:0050794|GO:0045321|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0007155|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0045058|GO:0019222|GO:0008284|GO:0002757|GO:0042127|GO:1903706|GO:0016337|GO:0045087|GO:0045595|GO:0006725|GO:0070661|GO:0050867|GO:1901360|GO:0010941|GO:0098797|GO:0007275|GO:0048513|GO:0070489|GO:0034641|GO:0044281|GO:0006952|GO:0030155|GO:0016772|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0042094|GO:0001817|GO:0098609|GO:0005737|GO:0002218|GO:0001816|GO:0043235|GO:0002696|GO:0001775|GO:0009966|GO:0001772|GO:0001819|GO:0019904|GO:0010646|GO:0006139|GO:0050776|GO:0055086|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0050778|GO:0070062|GO:0045785|GO:0008219|GO:0031295|GO:0045061|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0098857|GO:0031323|GO:0051090|GO:0042107|GO:1902533|GO:0051249|GO:0005829|GO:0042113|GO:0010468|GO:0034645|GO:0032943|GO:0042089|GO:0007166|GO:0030097|GO:0002758|GO:0030098|GO:0032623|GO:0019693|GO:0051252|GO:0034109|GO:0010628|GO:0009116|GO:0042101|GO:0051251|GO:0051091|GO:0002429|GO:0032743|GO:0022407|GO:0042035|GO:0007159|GO:0051247|GO:0002764|GO:0016301|GO:0042108|GO:0042110|GO:0012501|GO:0006796|GO:0035556|GO:0010467|GO:0050700|GO:0031328|GO:0051246|GO:0046651|GO:0009059|GO:0030154|GO:0022409|GO:0045121|GO:1902531|GO:0016070|GO:0010557|GO:0045076|GO:0043067|GO:0045089|GO:0016776|GO:0045088|GO:0045086|GO:0002521|GO:0042098|GO:0045893|GO:0050863|GO:0043122|GO:0009259|GO:0030183|GO:0009117|GO:0032774|GO:2001141|GO:0030217|GO:0045619|GO:0051092|GO:0002768|GO:0034112|GO:0019205|GO:0050871|GO:0070486|GO:0004385|GO:0043123|GO:0009132|GO:0007249|GO:0050864|GO:0006163|GO:0042981|GO:0033077|GO:0042100|GO:0050870|GO:0050851|GO:0050671|GO:0042278|GO:0006351|GO:0006915|GO:0006355|GO:1903039|GO:0032946|GO:0045577|GO:0030890|GO:0002223|GO:0045580|GO:1903506|GO:0038093|GO:0019201|GO:0030888|GO:0050852|GO:0042129|GO:0071593|GO:0042102|GO:0046037|GO:0046710|GO:0038095 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell proliferation|regulation of cellular process|leukocyte activation|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|cell adhesion|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|T cell selection|regulation of metabolic process|positive regulation of cell proliferation|immune response-activating signal transduction|regulation of cell proliferation|regulation of hemopoiesis|single organismal cell-cell adhesion|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|leukocyte proliferation|positive regulation of cell activation|organic cyclic compound metabolic process|regulation of cell death|plasma membrane protein complex|multicellular organism development|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|regulation of cell adhesion|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|interleukin-2 biosynthetic process|regulation of cytokine production|cell-cell adhesion|cytoplasm|activation of innate immune response|cytokine production|receptor complex|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|immunological synapse|positive regulation of cytokine production|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|regulation of immune response|nucleobase-containing small molecule metabolic process|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|positive regulation of immune response|extracellular exosome|positive regulation of cell adhesion|cell death|T cell costimulation|thymic T cell selection|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|membrane microdomain|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|cytokine metabolic process|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|cytosol|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|mononuclear cell proliferation|cytokine biosynthetic process|cell surface receptor signaling pathway|hemopoiesis|innate immune response-activating signal transduction|lymphocyte differentiation|interleukin-2 production|ribose phosphate metabolic process|regulation of RNA metabolic process|homotypic cell-cell adhesion|positive regulation of gene expression|nucleoside metabolic process|T cell receptor complex|positive regulation of lymphocyte activation|positive regulation of sequence-specific DNA binding transcription factor activity|immune response-activating cell surface receptor signaling pathway|positive regulation of interleukin-2 production|regulation of cell-cell adhesion|regulation of cytokine biosynthetic process|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|immune response-regulating signaling pathway|kinase activity|positive regulation of cytokine biosynthetic process|T cell activation|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|gene expression|CARD domain binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|membrane raft|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of programmed cell death|positive regulation of innate immune response|phosphotransferase activity, phosphate group as acceptor|regulation of innate immune response|positive regulation of interleukin-2 biosynthetic process|leukocyte differentiation|T cell proliferation|positive regulation of transcription, DNA-templated|regulation of T cell activation|regulation of I-kappaB kinase/NF-kappaB signaling|ribonucleotide metabolic process|B cell differentiation|nucleotide metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|T cell differentiation|regulation of lymphocyte differentiation|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|positive regulation of homotypic cell-cell adhesion|nucleobase-containing compound kinase activity|positive regulation of B cell activation|leukocyte aggregation|guanylate kinase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|nucleoside diphosphate metabolic process|I-kappaB kinase/NF-kappaB signaling|regulation of B cell activation|purine nucleotide metabolic process|regulation of apoptotic process|T cell differentiation in thymus|B cell proliferation|positive regulation of T cell activation|antigen receptor-mediated signaling pathway|positive regulation of lymphocyte proliferation|purine nucleoside metabolic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|regulation of B cell differentiation|positive regulation of B cell proliferation|stimulatory C-type lectin receptor signaling pathway|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|Fc receptor signaling pathway|nucleotide kinase activity|regulation of B cell proliferation|T cell receptor signaling pathway|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of T cell proliferation|GMP metabolic process|GDP metabolic process|Fc-epsilon receptor signaling pathway K07367 caspase recruitment domain-containing protein 11[-] hsa04660|hsa04064|hsa04662 T cell receptor signaling pathway - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human) 7:2906141-3043945 250 247 362 1779 1865 1613 3.20075762324489 2.87402607026028 4.17865232355233 20.4073704532022 19.59116558919 19.3542634347214 3.41781200568583 19.7842664923712 -2.53320862805349 5.81065989942944e-31 1.44559533864639e-28 DOWN ENSG00000039560 RAI14 retinoic acid induced 14 [Source:HGNC Symbol;Acc:HGNC:14873] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005938|GO:0043231|GO:0005737|GO:0031981|GO:0005654|GO:0005739|GO:0005856|GO:0005634|GO:0015629 cell|binding|intracellular organelle|membrane-bounded organelle|cell periphery|intracellular|protein binding|cell cortex|intracellular membrane-bounded organelle|cytoplasm|nuclear lumen|nucleoplasm|mitochondrion|cytoskeleton|nucleus|actin cytoskeleton - - - - 5:34656237-34832627 210 187 440 2517 2909 2952 1.04691738872392 0.847258856398891 1.97770164540579 11.2428114835927 11.898868480606 13.7923786161226 1.29062596350953 12.3113528601071 -3.25384644557248 9.63066355721514e-31 2.37614735402563e-28 DOWN ENSG00000163597 SNHG16 small nucleolar RNA host gene 16 [Source:HGNC Symbol;Acc:HGNC:44352] - - - - - - 17:76557766-76565348 3268 3297 3173 640 785 677 18.2165498808767 16.7025617633265 15.9466130212611 3.19640655523414 3.59022763103051 3.53672899611878 16.9552415551548 3.44112106079448 2.30078078506526 1.27064616048749e-30 3.10933364550767e-28 UP ENSG00000005810 MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:23386] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0051252|GO:0036211|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0046914|GO:0006464|GO:0006351|GO:0006355|GO:1903506|GO:0008270|GO:0032446|GO:0016567 cell|membrane|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|regulation of RNA metabolic process|protein modification process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 13:77044655-77327050 386 381 389 2058 2319 2464 1.28322277732967 1.1511181744893 1.16594736898962 6.12996383627384 6.32533618851302 7.67687738439065 1.2000961069362 6.71072580305917 -2.48331886514185 1.49712386025366e-30 3.63375087187095e-28 DOWN ENSG00000165533 TTC8 tetratricopeptide repeat domain 8 [Source:HGNC Symbol;Acc:HGNC:20087] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0042995|GO:0009892|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0031090|GO:0019222|GO:0006935|GO:0060041|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:0007275|GO:0048513|GO:0050877|GO:0060170|GO:0030900|GO:0051128|GO:0048560|GO:0007420|GO:0022607|GO:0005737|GO:0007389|GO:0032970|GO:0060322|GO:0007423|GO:0032880|GO:0006928|GO:0009887|GO:0035264|GO:0003407|GO:0048729|GO:0045184|GO:0072372|GO:0021988|GO:0036064|GO:0032231|GO:0008104|GO:0044092|GO:0021772|GO:0008134|GO:0050790|GO:0030030|GO:0031253|GO:0043086|GO:0048869|GO:0030029|GO:0021537|GO:0034464|GO:0006996|GO:0051017|GO:0000902|GO:0005829|GO:0031175|GO:0005813|GO:0001654|GO:0032956|GO:0007010|GO:0007417|GO:0001085|GO:0001655|GO:0009798|GO:0005815|GO:0070491|GO:0015031|GO:0000904|GO:0044782|GO:0072001|GO:0007600|GO:0060042|GO:0030031|GO:0051346|GO:0061326|GO:0030036|GO:0070925|GO:0060429|GO:0060219|GO:0042384|GO:0033043|GO:0032990|GO:0007399|GO:0050890|GO:0097485|GO:0030154|GO:0048858|GO:0005856|GO:0051492|GO:0031513|GO:0048666|GO:0030182|GO:0060271|GO:0007411|GO:0045444|GO:0032391|GO:0043010|GO:0050893|GO:0043087|GO:0061564|GO:0051493|GO:0015630|GO:0001103|GO:0031032|GO:0022008|GO:0030038|GO:0048667|GO:0007015|GO:0048812|GO:0007606|GO:0034260|GO:0048592|GO:0007608|GO:0007409|GO:0048593|GO:0048699|GO:0001754|GO:0043149|GO:0061572 locomotion|developmental process|growth|macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cell projection|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|developmental growth|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|chemotaxis|retina development in camera-type eye|tissue development|cell development|transport|tube development|multicellular organism development|animal organ development|neurological system process|ciliary membrane|forebrain development|regulation of cellular component organization|establishment of anatomical structure orientation|brain development|cellular component assembly|cytoplasm|pattern specification process|regulation of actin filament-based process|head development|sensory organ development|regulation of protein localization|movement of cell or subcellular component|organ morphogenesis|multicellular organism growth|neural retina development|tissue morphogenesis|establishment of protein localization|primary cilium|olfactory lobe development|ciliary basal body|regulation of actin filament bundle assembly|protein localization|negative regulation of molecular function|olfactory bulb development|transcription factor binding|regulation of catalytic activity|cell projection organization|cell projection membrane|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|telencephalon development|BBSome|organelle organization|actin filament bundle assembly|cell morphogenesis|cytosol|neuron projection development|centrosome|eye development|regulation of actin cytoskeleton organization|cytoskeleton organization|central nervous system development|RNA polymerase II transcription factor binding|urogenital system development|axis specification|microtubule organizing center|repressing transcription factor binding|protein transport|cell morphogenesis involved in differentiation|cilium organization|renal system development|sensory perception|retina morphogenesis in camera-type eye|cell projection assembly|negative regulation of hydrolase activity|renal tubule development|actin cytoskeleton organization|organelle assembly|epithelium development|camera-type eye photoreceptor cell differentiation|cilium assembly|regulation of organelle organization|cell part morphogenesis|nervous system development|cognition|neuron projection guidance|cell differentiation|cell projection morphogenesis|cytoskeleton|regulation of stress fiber assembly|nonmotile primary cilium|neuron development|neuron differentiation|cilium morphogenesis|axon guidance|fat cell differentiation|photoreceptor connecting cilium|camera-type eye development|sensory processing|regulation of GTPase activity|axon development|regulation of cytoskeleton organization|microtubule cytoskeleton|RNA polymerase II repressing transcription factor binding|actomyosin structure organization|neurogenesis|contractile actin filament bundle assembly|cell morphogenesis involved in neuron differentiation|actin filament organization|neuron projection morphogenesis|sensory perception of chemical stimulus|negative regulation of GTPase activity|eye morphogenesis|sensory perception of smell|axonogenesis|camera-type eye morphogenesis|generation of neurons|eye photoreceptor cell differentiation|stress fiber assembly|actin filament bundle organization - - - - 14:88824153-88881078 19 12 20 274 284 223 0.106495311132297 0.0611289718659932 0.101074567348199 1.37605202459305 1.30609079472157 1.17143856218238 0.0895662834488297 1.28452712716567 -3.84213780493214 1.53632365074256e-30 3.69882308623132e-28 DOWN ENSG00000065833 ME1 malic enzyme 1, NADP(+)-dependent, cytosolic [Source:HGNC Symbol;Acc:HGNC:6983] GO:0009055|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0048037|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0016830|GO:0044255|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0019637|GO:0046483|GO:0016614|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0051186|GO:0006139|GO:0055086|GO:0006629|GO:0009725|GO:0050662|GO:0000166|GO:0044249|GO:0010033|GO:0031323|GO:0055114|GO:0005829|GO:0009743|GO:0046872|GO:0001883|GO:0050661|GO:0032549|GO:0043531|GO:0016616|GO:0016831|GO:0005739|GO:0006461|GO:0006796|GO:0051174|GO:0017076|GO:0016615|GO:0051287|GO:0051259|GO:0009117|GO:0030554|GO:0004471|GO:0009108|GO:0008948|GO:0004470|GO:0046914|GO:0019752|GO:0009165|GO:0004473|GO:0043648|GO:0030145|GO:1902031|GO:0019363|GO:0051262|GO:0006739|GO:0006108|GO:0006741 electron carrier activity|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|cofactor binding|biosynthetic process|intracellular|protein binding|regulation of metabolic process|carbon-carbon lyase activity|cellular lipid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|organophosphate metabolic process|heterocycle metabolic process|oxidoreductase activity, acting on CH-OH group of donors|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|lipid metabolic process|response to hormone|coenzyme binding|nucleotide binding|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|oxidation-reduction process|cytosol|response to carbohydrate|metal ion binding|purine nucleoside binding|NADP binding|ribonucleoside binding|ADP binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|carboxy-lyase activity|mitochondrion|protein complex assembly|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|malate dehydrogenase activity|NAD binding|protein oligomerization|nucleotide metabolic process|adenyl nucleotide binding|malate dehydrogenase (decarboxylating) (NAD+) activity|coenzyme biosynthetic process|oxaloacetate decarboxylase activity|malic enzyme activity|transition metal ion binding|carboxylic acid metabolic process|nucleotide biosynthetic process|malate dehydrogenase (decarboxylating) (NADP+) activity|dicarboxylic acid metabolic process|manganese ion binding|regulation of NADP metabolic process|pyridine nucleotide biosynthetic process|protein tetramerization|NADP metabolic process|malate metabolic process|NADP biosynthetic process K00029 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+)[1.1.1.40] hsa01100|hsa01200|hsa03320|hsa00620 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Pyruvate metabolism - Homo sapiens (human) 6:83210389-83431071 279 295 432 2008 2173 1844 5.85451159458563 5.62586310827154 8.17305969465711 37.7527309742857 37.4123209246062 36.264101788223 6.55114479917143 37.1430512290383 -2.50327339291407 1.90698914912226e-30 4.55450032463167e-28 DOWN ENSG00000116815 CD58 CD58 molecule [Source:HGNC Symbol;Acc:HGNC:1688] GO:0040011|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0051050|GO:0006950|GO:0050900|GO:0006955|GO:0009986|GO:0051641|GO:0048870|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0031225|GO:0060341|GO:0050817|GO:0016337|GO:0045087|GO:0006810|GO:0005102|GO:0032940|GO:0006952|GO:0031982|GO:0001817|GO:0098609|GO:0005887|GO:0001816|GO:0009611|GO:0032880|GO:0051222|GO:0006928|GO:0045184|GO:0001819|GO:0031226|GO:0008104|GO:0016477|GO:0070062|GO:0051047|GO:0016021|GO:0010033|GO:0050878|GO:0034097|GO:0007596|GO:0051223|GO:0015031|GO:0070201|GO:0042060|GO:0050714|GO:0032757|GO:0050715|GO:0051046|GO:0034341|GO:0007599|GO:0009306|GO:0050663|GO:0034113|GO:0046903|GO:0071310|GO:0050707|GO:0032637|GO:0072606|GO:2000484|GO:0071346|GO:0050708|GO:0071345|GO:0034612|GO:2000482|GO:0071356 locomotion|immune system process|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|positive regulation of transport|response to stress|leukocyte migration|immune response|cell surface|cellular localization|cell motility|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|anchored component of membrane|regulation of cellular localization|coagulation|single organismal cell-cell adhesion|innate immune response|transport|receptor binding|secretion by cell|defense response|vesicle|regulation of cytokine production|cell-cell adhesion|integral component of plasma membrane|cytokine production|response to wounding|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|establishment of protein localization|positive regulation of cytokine production|intrinsic component of plasma membrane|protein localization|cell migration|extracellular exosome|positive regulation of secretion|integral component of membrane|response to organic substance|regulation of body fluid levels|response to cytokine|blood coagulation|regulation of protein transport|protein transport|regulation of establishment of protein localization|wound healing|positive regulation of protein secretion|positive regulation of interleukin-8 production|positive regulation of cytokine secretion|regulation of secretion|response to interferon-gamma|hemostasis|protein secretion|cytokine secretion|heterotypic cell-cell adhesion|secretion|cellular response to organic substance|regulation of cytokine secretion|interleukin-8 production|interleukin-8 secretion|positive regulation of interleukin-8 secretion|cellular response to interferon-gamma|regulation of protein secretion|cellular response to cytokine stimulus|response to tumor necrosis factor|regulation of interleukin-8 secretion|cellular response to tumor necrosis factor K06492 CD58 antigen[-] hsa05169|hsa04514 Epstein-Barr virus infection - Homo sapiens (human)|Cell adhesion molecules (CAMs) - Homo sapiens (human) 1:116514535-116571039 172 202 196 1201 1218 1008 4.85699368288402 5.1840459161565 4.99008560861763 30.3863501769344 28.2197594768668 26.676416301013 5.01037506921938 28.4275086516047 -2.50429715813525 1.98870513455379e-30 4.71196849896579e-28 DOWN ENSG00000075568 TMEM131 transmembrane protein 131 [Source:HGNC Symbol;Acc:HGNC:30366] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 2:97756333-97995891 165 235 310 1383 1608 1604 0.710513246759169 0.919677750851598 1.20354672990511 5.33589442128157 5.68121944730188 6.47322476725426 0.944579242505292 5.83011287861257 -2.62578007899242 2.25351028305067e-30 5.23961917018697e-28 DOWN ENSG00000075711 DLG1 discs, large homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:2900] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0000003|GO:0002376|GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0005604|GO:1903561|GO:0051716|GO:0042995|GO:0002683|GO:0009892|GO:0048523|GO:0031594|GO:0008283|GO:0050794|GO:0045321|GO:0060076|GO:0043229|GO:0005578|GO:0006807|GO:0051050|GO:0006950|GO:0043209|GO:0044089|GO:0042175|GO:0071704|GO:0006955|GO:0032947|GO:0044237|GO:0051641|GO:0003006|GO:0023051|GO:0005911|GO:0043219|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0050793|GO:0016247|GO:0005622|GO:0002682|GO:0005789|GO:1903829|GO:0005515|GO:0035748|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0005605|GO:0048856|GO:0097060|GO:0031090|GO:0019222|GO:0016032|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0002250|GO:0007049|GO:0060022|GO:0016337|GO:0009898|GO:0008360|GO:0042391|GO:0006935|GO:0035239|GO:0006725|GO:0051640|GO:0070661|GO:0001822|GO:0009888|GO:0048468|GO:0008022|GO:0016323|GO:0044325|GO:0006810|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0031641|GO:0002088|GO:0098797|GO:0007275|GO:0048513|GO:0070489|GO:0032535|GO:0072028|GO:0044291|GO:0005102|GO:0034641|GO:0016788|GO:0005874|GO:0044281|GO:0030155|GO:0005912|GO:0043270|GO:0016772|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0045211|GO:0022607|GO:0098609|GO:0051668|GO:0005887|GO:0045786|GO:0043231|GO:0048608|GO:0019899|GO:0005737|GO:0032970|GO:0003012|GO:0001763|GO:0001816|GO:0007267|GO:0007423|GO:0032880|GO:0043235|GO:0006928|GO:0009887|GO:0051656|GO:0001775|GO:0098562|GO:0043005|GO:0015459|GO:0009966|GO:0048729|GO:0048598|GO:0072006|GO:0048568|GO:0002367|GO:0050673|GO:0045184|GO:0009890|GO:0001772|GO:0042383|GO:0014069|GO:0008037|GO:0019904|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0007162|GO:0055086|GO:0008104|GO:0046649|GO:0050865|GO:1902495|GO:0007163|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0090004|GO:0005783|GO:0009968|GO:0070062|GO:0016328|GO:0051649|GO:0008092|GO:0002695|GO:0008285|GO:0050790|GO:0030030|GO:0031253|GO:0048869|GO:0016021|GO:0030029|GO:0044249|GO:0007017|GO:0019538|GO:0031334|GO:0043254|GO:0023014|GO:0098857|GO:0031324|GO:0031323|GO:0043296|GO:0010256|GO:0005794|GO:0060021|GO:0002443|GO:0006996|GO:0000165|GO:0002369|GO:0051249|GO:0043113|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0048705|GO:0008328|GO:0001771|GO:0010468|GO:0006936|GO:0000075|GO:0034645|GO:0045216|GO:0032943|GO:0090150|GO:0001654|GO:0032956|GO:0002009|GO:1903047|GO:0030424|GO:0043412|GO:0007010|GO:0072164|GO:0061458|GO:0001655|GO:0010629|GO:0019693|GO:0051252|GO:0097025|GO:0034109|GO:0048754|GO:0014704|GO:0061138|GO:0000904|GO:0009790|GO:0001935|GO:0007009|GO:0009988|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0009116|GO:0070201|GO:0060537|GO:0072001|GO:0006811|GO:0044304|GO:0051250|GO:0034329|GO:0019902|GO:0051660|GO:0022408|GO:0022407|GO:0031579|GO:0072657|GO:0031098|GO:0007346|GO:0007159|GO:0097016|GO:0051247|GO:0045930|GO:0048471|GO:0034765|GO:0070664|GO:0022604|GO:0034702|GO:0007051|GO:0050678|GO:0035418|GO:0006461|GO:0016301|GO:0050680|GO:0061326|GO:0030036|GO:0043269|GO:0034613|GO:0043268|GO:0002460|GO:0019900|GO:0051642|GO:0032270|GO:0060993|GO:0042110|GO:0060429|GO:0006796|GO:1903078|GO:0035556|GO:0072073|GO:0042982|GO:0032273|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0031503|GO:0048562|GO:0007399|GO:0060562|GO:0097485|GO:1902532|GO:0051246|GO:0046651|GO:0009059|GO:0030154|GO:0001501|GO:0030832|GO:0048858|GO:0045121|GO:0001823|GO:0005923|GO:1903827|GO:1902531|GO:0016070|GO:0000226|GO:0005856|GO:0005634|GO:0042578|GO:0016776|GO:0035254|GO:0051960|GO:0033268|GO:0008366|GO:0034220|GO:0010638|GO:0048666|GO:0030182|GO:1903038|GO:0051896|GO:0007411|GO:0043491|GO:0048706|GO:0042098|GO:0090003|GO:0016311|GO:0098655|GO:0002456|GO:0009792|GO:0051898|GO:0031401|GO:0050863|GO:0006939|GO:0034622|GO:0001657|GO:0009259|GO:0030838|GO:0043408|GO:0045892|GO:0043010|GO:0009117|GO:0007093|GO:0072659|GO:0030866|GO:0090002|GO:0032774|GO:0031122|GO:0035255|GO:0050868|GO:0006812|GO:2001141|GO:0072078|GO:0043623|GO:0072163|GO:0016310|GO:0001658|GO:1902679|GO:0034629|GO:0070371|GO:0019205|GO:0070486|GO:0008064|GO:0061564|GO:0097120|GO:0004385|GO:0051493|GO:0061333|GO:0030865|GO:0015630|GO:0009132|GO:0006163|GO:0072080|GO:0032872|GO:0016791|GO:0043409|GO:0048745|GO:0048704|GO:1903076|GO:0034111|GO:0032945|GO:0042552|GO:0019901|GO:0022008|GO:0035088|GO:0048667|GO:0006464|GO:0007015|GO:0051495|GO:0048812|GO:0007043|GO:1990778|GO:0051403|GO:0042278|GO:0030953|GO:0030833|GO:0050672|GO:0043549|GO:0006351|GO:0006355|GO:0033674|GO:0006470|GO:0070830|GO:0051258|GO:0006366|GO:0045859|GO:1903507|GO:0045860|GO:1900744|GO:0043297|GO:0006357|GO:0043266|GO:0007409|GO:0038066|GO:0006468|GO:0048699|GO:0031434|GO:1903506|GO:0042325|GO:0004721|GO:0001932|GO:0060675|GO:0042326|GO:0019201|GO:0002028|GO:0043009|GO:1902305|GO:0030001|GO:0001934|GO:0045197|GO:0042130|GO:0042129|GO:0001933|GO:0000122|GO:0070372|GO:0071593|GO:0070373|GO:0043622|GO:0015672|GO:0032873|GO:0042327|GO:0007268|GO:0008154|GO:0046037|GO:0006813|GO:0030432|GO:0035725|GO:0046710|GO:0006814|GO:1903753|GO:0030041|GO:0032147 locomotion|developmental process|extracellular matrix|macromolecular complex|reproduction|immune system process|synapse|structural molecule activity|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|basement membrane|extracellular vesicle|cellular response to stimulus|cell projection|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|neuromuscular junction|cell proliferation|regulation of cellular process|leukocyte activation|excitatory synapse|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|positive regulation of transport|response to stress|myelin sheath|positive regulation of cellular component biogenesis|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|immune response|protein complex scaffold|cellular metabolic process|cellular localization|developmental process involved in reproduction|regulation of signaling|cell-cell junction|lateral loop|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|regulation of developmental process|channel regulator activity|intracellular|regulation of immune system process|endoplasmic reticulum membrane|positive regulation of cellular protein localization|protein binding|myelin sheath abaxonal region|plasma membrane|protein complex|endomembrane system|transferase activity|basal lamina|anatomical structure development|synaptic membrane|organelle membrane|regulation of metabolic process|viral process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|adaptive immune response|cell cycle|hard palate development|single organismal cell-cell adhesion|cytoplasmic side of plasma membrane|regulation of cell shape|regulation of membrane potential|chemotaxis|tube morphogenesis|cellular aromatic compound metabolic process|organelle localization|leukocyte proliferation|kidney development|tissue development|cell development|protein C-terminus binding|basolateral plasma membrane|ion channel binding|transport|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of myelination|lens development in camera-type eye|plasma membrane protein complex|multicellular organism development|animal organ development|T cell aggregation|regulation of cellular component size|nephron morphogenesis|cell-cell contact zone|receptor binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|microtubule|small molecule metabolic process|regulation of cell adhesion|adherens junction|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|postsynaptic membrane|cellular component assembly|cell-cell adhesion|localization within membrane|integral component of plasma membrane|negative regulation of cell cycle|intracellular membrane-bounded organelle|reproductive structure development|enzyme binding|cytoplasm|regulation of actin filament-based process|muscle system process|morphogenesis of a branching structure|cytokine production|cell-cell signaling|sensory organ development|regulation of protein localization|receptor complex|movement of cell or subcellular component|organ morphogenesis|establishment of organelle localization|cell activation|cytoplasmic side of membrane|neuron projection|potassium channel regulator activity|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|nephron development|embryonic organ development|cytokine production involved in immune response|epithelial cell proliferation|establishment of protein localization|negative regulation of biosynthetic process|immunological synapse|sarcolemma|postsynaptic density|cell recognition|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|negative regulation of cell adhesion|nucleobase-containing small molecule metabolic process|protein localization|lymphocyte activation|regulation of cell activation|transmembrane transporter complex|establishment or maintenance of cell polarity|cell communication|transmembrane transport|membrane organization|signal transduction|positive regulation of establishment of protein localization to plasma membrane|endoplasmic reticulum|negative regulation of signal transduction|extracellular exosome|lateral plasma membrane|establishment of localization in cell|cytoskeletal protein binding|negative regulation of leukocyte activation|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|cell projection membrane|cellular developmental process|integral component of membrane|actin filament-based process|cellular biosynthetic process|microtubule-based process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|signal transduction by protein phosphorylation|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|apical junction complex|endomembrane system organization|Golgi apparatus|palate development|leukocyte mediated immunity|organelle organization|MAPK cascade|T cell cytokine production|regulation of lymphocyte activation|receptor clustering|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|skeletal system morphogenesis|ionotropic glutamate receptor complex|immunological synapse formation|regulation of gene expression|muscle contraction|cell cycle checkpoint|cellular macromolecule biosynthetic process|cell-cell junction organization|mononuclear cell proliferation|establishment of protein localization to membrane|eye development|regulation of actin cytoskeleton organization|morphogenesis of an epithelium|mitotic cell cycle process|axon|macromolecule modification|cytoskeleton organization|mesonephric tubule development|reproductive system development|urogenital system development|negative regulation of gene expression|ribose phosphate metabolic process|regulation of RNA metabolic process|MPP7-DLG1-LIN7 complex|homotypic cell-cell adhesion|branching morphogenesis of an epithelial tube|intercalated disc|morphogenesis of a branching epithelium|cell morphogenesis involved in differentiation|embryo development|endothelial cell proliferation|plasma membrane organization|cell-cell recognition|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|nucleoside metabolic process|regulation of establishment of protein localization|muscle tissue development|renal system development|ion transport|main axon|negative regulation of lymphocyte activation|cell junction assembly|phosphatase binding|establishment of centrosome localization|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|membrane raft organization|protein localization to membrane|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|leukocyte cell-cell adhesion|L27 domain binding|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|perinuclear region of cytoplasm|regulation of ion transmembrane transport|negative regulation of leukocyte proliferation|regulation of cell morphogenesis|ion channel complex|spindle organization|regulation of epithelial cell proliferation|protein localization to synapse|protein complex assembly|kinase activity|negative regulation of epithelial cell proliferation|renal tubule development|actin cytoskeleton organization|regulation of ion transport|cellular protein localization|positive regulation of potassium ion transport|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|kinase binding|centrosome localization|positive regulation of cellular protein metabolic process|kidney morphogenesis|T cell activation|epithelium development|phosphate-containing compound metabolic process|positive regulation of protein localization to plasma membrane|intracellular signal transduction|kidney epithelium development|amyloid precursor protein metabolic process|positive regulation of protein polymerization|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|protein complex localization|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|neuron projection guidance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|skeletal system development|regulation of actin filament length|cell projection morphogenesis|membrane raft|mesonephros development|bicellular tight junction|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|microtubule cytoskeleton organization|cytoskeleton|nucleus|phosphoric ester hydrolase activity|phosphotransferase activity, phosphate group as acceptor|glutamate receptor binding|regulation of nervous system development|node of Ranvier|axon ensheathment|ion transmembrane transport|positive regulation of organelle organization|neuron development|neuron differentiation|negative regulation of leukocyte cell-cell adhesion|regulation of protein kinase B signaling|axon guidance|protein kinase B signaling|embryonic skeletal system development|T cell proliferation|regulation of establishment of protein localization to plasma membrane|dephosphorylation|cation transmembrane transport|T cell mediated immunity|embryo development ending in birth or egg hatching|negative regulation of protein kinase B signaling|positive regulation of protein modification process|regulation of T cell activation|smooth muscle contraction|cellular macromolecular complex assembly|ureteric bud development|ribonucleotide metabolic process|positive regulation of actin filament polymerization|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|camera-type eye development|nucleotide metabolic process|mitotic cell cycle checkpoint|protein localization to plasma membrane|cortical actin cytoskeleton organization|establishment of protein localization to plasma membrane|RNA biosynthetic process|cytoplasmic microtubule organization|ionotropic glutamate receptor binding|negative regulation of T cell activation|cation transport|regulation of RNA biosynthetic process|nephron tubule morphogenesis|cellular protein complex assembly|mesonephric epithelium development|phosphorylation|branching involved in ureteric bud morphogenesis|negative regulation of RNA biosynthetic process|cellular protein complex localization|ERK1 and ERK2 cascade|nucleobase-containing compound kinase activity|leukocyte aggregation|regulation of actin polymerization or depolymerization|axon development|receptor localization to synapse|guanylate kinase activity|regulation of cytoskeleton organization|renal tubule morphogenesis|cortical cytoskeleton organization|microtubule cytoskeleton|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|nephron tubule development|regulation of stress-activated MAPK cascade|phosphatase activity|negative regulation of MAPK cascade|smooth muscle tissue development|embryonic skeletal system morphogenesis|regulation of protein localization to plasma membrane|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|myelination|protein kinase binding|neurogenesis|establishment or maintenance of apical/basal cell polarity|cell morphogenesis involved in neuron differentiation|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|neuron projection morphogenesis|cell-cell junction assembly|protein localization to cell periphery|stress-activated MAPK cascade|purine nucleoside metabolic process|astral microtubule organization|regulation of actin filament polymerization|negative regulation of lymphocyte proliferation|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of kinase activity|protein dephosphorylation|bicellular tight junction assembly|protein polymerization|transcription from RNA polymerase II promoter|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|regulation of p38MAPK cascade|apical junction assembly|regulation of transcription from RNA polymerase II promoter|regulation of potassium ion transport|axonogenesis|p38MAPK cascade|protein phosphorylation|generation of neurons|mitogen-activated protein kinase kinase binding|regulation of nucleic acid-templated transcription|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|ureteric bud morphogenesis|negative regulation of phosphorylation|nucleotide kinase activity|regulation of sodium ion transport|chordate embryonic development|regulation of sodium ion transmembrane transport|metal ion transport|positive regulation of protein phosphorylation|establishment or maintenance of epithelial cell apical/basal polarity|negative regulation of T cell proliferation|regulation of T cell proliferation|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|regulation of ERK1 and ERK2 cascade|lymphocyte aggregation|negative regulation of ERK1 and ERK2 cascade|cortical microtubule organization|monovalent inorganic cation transport|negative regulation of stress-activated MAPK cascade|positive regulation of phosphorylation|synaptic transmission|actin polymerization or depolymerization|GMP metabolic process|potassium ion transport|peristalsis|sodium ion transmembrane transport|GDP metabolic process|sodium ion transport|negative regulation of p38MAPK cascade|actin filament polymerization|activation of protein kinase activity K12076 disks large protein 1[-] hsa05166|hsa05203|hsa04390|hsa04660 HTLV-I infection - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human) 3:197042560-197299300 149 146 300 1578 1702 1689 0.512935460209915 0.456781492288502 0.931134337187945 4.86721759530595 4.80732685801299 5.44922409851547 0.633617096562121 5.0412561839448 -2.99210010179045 2.25397948746708e-30 5.23961917018697e-28 DOWN ENSG00000159346 ADIPOR1 adiponectin receptor 1 [Source:HGNC Symbol;Acc:HGNC:24040] GO:0040007|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0050794|GO:0042562|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0023051|GO:0045926|GO:0016043|GO:0071944|GO:0040008|GO:0031224|GO:0005515|GO:0005886|GO:0019222|GO:0042802|GO:0044262|GO:0044255|GO:0006082|GO:0055100|GO:0044281|GO:0051128|GO:1900076|GO:0043169|GO:0019899|GO:0010243|GO:0004888|GO:0030308|GO:0005975|GO:0042592|GO:0009966|GO:0046983|GO:0010646|GO:0031226|GO:0007154|GO:1900078|GO:0006629|GO:0007165|GO:0009725|GO:0016021|GO:0009967|GO:0010033|GO:0001558|GO:0031323|GO:0055114|GO:1902533|GO:0006109|GO:0007186|GO:0046872|GO:0007166|GO:0046628|GO:0034097|GO:0046982|GO:0048878|GO:0006631|GO:0044321|GO:1901652|GO:0071417|GO:0034440|GO:0043434|GO:0005996|GO:0019900|GO:0035556|GO:0019216|GO:0071310|GO:0009755|GO:0046626|GO:0030258|GO:1902531|GO:0004930|GO:0032870|GO:0019318|GO:0044320|GO:0019221|GO:1901653|GO:0016500|GO:0033211|GO:0010906|GO:0007167|GO:0071375|GO:0071345|GO:0019752|GO:0032868|GO:0019901|GO:0019395|GO:0033500|GO:0042593|GO:0097003|GO:0007259|GO:0033210|GO:0006006|GO:0046425|GO:0032869|GO:0046427|GO:0032787|GO:0007169|GO:0008286 growth|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|regulation of cellular process|hormone binding|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|regulation of signaling|negative regulation of growth|cellular component organization|cell periphery|regulation of growth|intrinsic component of membrane|protein binding|plasma membrane|regulation of metabolic process|identical protein binding|cellular carbohydrate metabolic process|cellular lipid metabolic process|organic acid metabolic process|adiponectin binding|small molecule metabolic process|regulation of cellular component organization|regulation of cellular response to insulin stimulus|cation binding|enzyme binding|response to organonitrogen compound|transmembrane signaling receptor activity|negative regulation of cell growth|carbohydrate metabolic process|homeostatic process|regulation of signal transduction|protein dimerization activity|regulation of cell communication|intrinsic component of plasma membrane|cell communication|positive regulation of cellular response to insulin stimulus|lipid metabolic process|signal transduction|response to hormone|integral component of membrane|positive regulation of signal transduction|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|oxidation-reduction process|positive regulation of intracellular signal transduction|regulation of carbohydrate metabolic process|G-protein coupled receptor signaling pathway|metal ion binding|cell surface receptor signaling pathway|positive regulation of insulin receptor signaling pathway|response to cytokine|protein heterodimerization activity|chemical homeostasis|fatty acid metabolic process|response to leptin|response to peptide|cellular response to organonitrogen compound|lipid oxidation|response to peptide hormone|monosaccharide metabolic process|kinase binding|intracellular signal transduction|regulation of lipid metabolic process|cellular response to organic substance|hormone-mediated signaling pathway|regulation of insulin receptor signaling pathway|lipid modification|regulation of intracellular signal transduction|G-protein coupled receptor activity|cellular response to hormone stimulus|hexose metabolic process|cellular response to leptin stimulus|cytokine-mediated signaling pathway|cellular response to peptide|protein-hormone receptor activity|adiponectin-activated signaling pathway|regulation of glucose metabolic process|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|cellular response to cytokine stimulus|carboxylic acid metabolic process|response to insulin|protein kinase binding|fatty acid oxidation|carbohydrate homeostasis|glucose homeostasis|adipokinetic hormone receptor activity|JAK-STAT cascade|leptin-mediated signaling pathway|glucose metabolic process|regulation of JAK-STAT cascade|cellular response to insulin stimulus|positive regulation of JAK-STAT cascade|monocarboxylic acid metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|insulin receptor signaling pathway K07297 adiponectin receptor[-] hsa04932|hsa04152|hsa04211|hsa04920 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human) 1:202940823-202958572 349 383 742 3836 4131 3767 4.9994275082048 4.98624283534659 9.58325498404094 49.2346584586221 48.5531954290218 50.5730625337774 6.52297510919744 49.4536388071404 -2.92247465012346 2.26405464244027e-30 5.23961917018697e-28 DOWN ENSG00000181982 CCDC149 coiled-coil domain containing 149 [Source:HGNC Symbol;Acc:HGNC:25405] - - - - - - 4:24806117-24980204 3 5 9 134 155 187 0.0162668674269138 0.0246391457847181 0.0439924192376449 0.650937209815871 0.68949997280571 0.95017902614717 0.0282994774830923 0.76353873625625 -4.75385402972531 2.48353030964513e-30 5.70333183570351e-28 DOWN ENSG00000108094 CUL2 cullin 2 [Source:HGNC Symbol;Acc:HGNC:2552] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0016032|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0045786|GO:0043231|GO:0019899|GO:0005737|GO:0032403|GO:0006139|GO:0007154|GO:0007165|GO:0008219|GO:0008285|GO:0001666|GO:0019787|GO:0000151|GO:0044249|GO:0019538|GO:0031323|GO:0005730|GO:0005829|GO:0010468|GO:0034645|GO:1903047|GO:0043412|GO:0030163|GO:0004842|GO:0043620|GO:0031461|GO:0051252|GO:0044770|GO:0044265|GO:0007050|GO:0036211|GO:0000278|GO:0071456|GO:0031981|GO:1990234|GO:0006508|GO:0005654|GO:0071453|GO:0012501|GO:0035556|GO:0044267|GO:0010467|GO:0009059|GO:0000153|GO:0016070|GO:0005634|GO:0097190|GO:0044389|GO:0031625|GO:0044257|GO:0097193|GO:0031462|GO:0061630|GO:0032774|GO:0044772|GO:2001141|GO:0061418|GO:0051603|GO:0006464|GO:0006351|GO:0006915|GO:0006355|GO:0043618|GO:0030891|GO:0036294|GO:0006366|GO:0006357|GO:0019941|GO:1903506|GO:0000082|GO:0032446|GO:0006511|GO:0042787|GO:0016567 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|viral process|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein complex binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|cell death|negative regulation of cell proliferation|response to hypoxia|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|nucleolus|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|mitotic cell cycle process|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|regulation of DNA-templated transcription in response to stress|cullin-RING ubiquitin ligase complex|regulation of RNA metabolic process|cell cycle phase transition|cellular macromolecule catabolic process|cell cycle arrest|protein modification process|mitotic cell cycle|cellular response to hypoxia|nuclear lumen|transferase complex|proteolysis|nucleoplasm|cellular response to oxygen levels|programmed cell death|intracellular signal transduction|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|cytoplasmic ubiquitin ligase complex|RNA metabolic process|nucleus|apoptotic signaling pathway|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|intrinsic apoptotic signaling pathway|Cul2-RING ubiquitin ligase complex|ubiquitin protein ligase activity|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|regulation of transcription from RNA polymerase II promoter in response to hypoxia|proteolysis involved in cellular protein catabolic process|cellular protein modification process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|VCB complex|cellular response to decreased oxygen levels|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|G1/S transition of mitotic cell cycle|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination K03870 cullin 2[-] hsa05200|hsa04120|hsa04066|hsa05211 Pathways in cancer - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human) 10:35008551-35090642 214 263 260 1360 1442 1240 1.86310293431941 2.08093426110193 2.04084837280284 10.6086245200927 10.3004335627815 10.117491657099 1.99496185607473 10.3421832466577 -2.37410770505822 3.07912478437076e-30 7.01711384065685e-28 DOWN ENSG00000138190 EXOC6 exocyst complex component 6 [Source:HGNC Symbol;Acc:HGNC:23196] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0071704|GO:0044237|GO:0016043|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0006810|GO:0000145|GO:0005938|GO:0032940|GO:0005737|GO:0022406|GO:0045184|GO:0008104|GO:0061024|GO:0019538|GO:0006996|GO:0016192|GO:0005829|GO:0048278|GO:0015031|GO:0006887|GO:0044267|GO:0046903|GO:0006904 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic substance metabolic process|cellular metabolic process|cellular component organization|cell periphery|intracellular|protein binding|plasma membrane|protein complex|transport|exocyst|cell cortex|secretion by cell|cytoplasm|membrane docking|establishment of protein localization|protein localization|membrane organization|protein metabolic process|organelle organization|vesicle-mediated transport|cytosol|vesicle docking|protein transport|exocytosis|cellular protein metabolic process|secretion|vesicle docking involved in exocytosis - - - - 10:92834713-93059493 67 73 115 697 778 608 0.562404251910312 0.556900851599613 0.870334532898743 5.24207280040118 5.35822005562283 4.78305570139807 0.663213212136223 5.12778285247403 -2.95079051633726 3.25284954518767e-30 7.35686138803279e-28 DOWN ENSG00000197321 SVIL supervillin [Source:HGNC Symbol;Acc:HGNC:11480] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0030496|GO:0042995|GO:0030055|GO:0044877|GO:0050794|GO:0043229|GO:0009986|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0051726|GO:0007049|GO:0009888|GO:0022402|GO:0007275|GO:0048513|GO:0051302|GO:0005924|GO:0005874|GO:0005912|GO:0061061|GO:0043231|GO:0005737|GO:0032403|GO:0045787|GO:0008092|GO:0071437|GO:0043034|GO:0051781|GO:0051301|GO:0032154|GO:0006996|GO:0002102|GO:0032467|GO:1990752|GO:0090068|GO:0007010|GO:0003779|GO:0060537|GO:0032465|GO:0036449|GO:0043292|GO:0010564|GO:0051015|GO:0007517|GO:0005856|GO:0000910|GO:0005634|GO:0005925|GO:0015629|GO:0060538|GO:0030016|GO:0015630|GO:0014706|GO:0007519 developmental process|macromolecular complex|cell|membrane|cellular process|cell junction|binding|midbody|cell projection|cell-substrate junction|macromolecular complex binding|regulation of cellular process|intracellular organelle|cell surface|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of cell cycle|cell cycle|tissue development|cell cycle process|multicellular organism development|animal organ development|regulation of cell division|cell-substrate adherens junction|microtubule|adherens junction|muscle structure development|intracellular membrane-bounded organelle|cytoplasm|protein complex binding|positive regulation of cell cycle|cytoskeletal protein binding|invadopodium|costamere|positive regulation of cell division|cell division|cleavage furrow|organelle organization|podosome|positive regulation of cytokinesis|microtubule end|positive regulation of cell cycle process|cytoskeleton organization|actin binding|muscle tissue development|regulation of cytokinesis|microtubule minus-end|contractile fiber|regulation of cell cycle process|actin filament binding|muscle organ development|cytoskeleton|cytokinesis|nucleus|focal adhesion|actin cytoskeleton|skeletal muscle organ development|myofibril|microtubule cytoskeleton|striated muscle tissue development|skeletal muscle tissue development - - - - 10:29457338-29736781 162 158 284 1309 1394 1581 0.907241491979568 0.804163861015991 1.43397193639383 6.56818517299681 6.40528923457196 8.29791386861669 1.04845909646313 7.09046275872849 -2.75760920929574 3.33208253248406e-30 7.47939788908114e-28 DOWN ENSG00000109790 KLHL5 kelch like family member 5 [Source:HGNC Symbol;Acc:HGNC:6356] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0005737|GO:0008092|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0004842|GO:0031461|GO:0003779|GO:0036211|GO:1990234|GO:0044267|GO:0005856|GO:0006464|GO:0031463|GO:0032446|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|protein complex|transferase activity|cytoplasm|cytoskeletal protein binding|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|actin binding|protein modification process|transferase complex|cellular protein metabolic process|cytoskeleton|cellular protein modification process|Cul3-RING ubiquitin ligase complex|protein modification by small protein conjugation|protein ubiquitination - - - - 4:39045039-39126857 408 441 756 3452 3690 3665 3.07322105226592 3.01892563534528 5.13416452888877 23.2971280592491 22.8049024299976 25.8724087490428 3.74210373883332 23.9914797460965 -2.68060068416915 3.50623159731455e-30 7.81157000792751e-28 DOWN ENSG00000165675 ENOX2 ecto-NOX disulfide-thiol exchanger 2 [Source:HGNC Symbol;Acc:HGNC:2259] GO:0040007|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0016049|GO:0009986|GO:0007624|GO:0071944|GO:0040008|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0009897|GO:0003676|GO:0005737|GO:0016667|GO:0000166|GO:0055114|GO:0005829|GO:0015036|GO:0015035 growth|cell|rhythmic process|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|cell growth|cell surface|ultradian rhythm|cell periphery|regulation of growth|extracellular space|intracellular|protein binding|plasma membrane|external side of plasma membrane|nucleic acid binding|cytoplasm|oxidoreductase activity, acting on a sulfur group of donors|nucleotide binding|oxidation-reduction process|cytosol|disulfide oxidoreductase activity|protein disulfide oxidoreductase activity - - - - X:130623369-130903317 29 20 32 450 520 291 0.188424057767992 0.118099204701147 0.187455765182428 2.61967685311793 2.77210059352459 1.77198029525394 0.164659675883856 2.38791924729882 -3.85819485303155 3.6799596540982e-30 8.13789003803315e-28 DOWN ENSG00000196782 MAML3 mastermind like transcriptional coactivator 3 [Source:HGNC Symbol;Acc:HGNC:16272] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0000988|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0031323|GO:0003713|GO:0010468|GO:0034645|GO:0007166|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0016604|GO:0007219|GO:0006351|GO:0006355|GO:0016607|GO:0045944|GO:0006366|GO:0006352|GO:0007221|GO:0006357|GO:1903506|GO:0006367 signaling|cell|cellular process|metabolic process|response to stimulus|transcription factor activity, protein binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear body|Notch signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|positive regulation of transcription of Notch receptor target|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription initiation from RNA polymerase II promoter K06061 mastermind[-] hsa04330 Notch signaling pathway - Homo sapiens (human) 4:139716753-140154184 17 10 15 246 230 323 0.152273483676492 0.0814072458896663 0.121139344785847 1.97431642339939 1.69036195148242 2.71153291041132 0.118273358117335 2.12540376176438 -4.16753989679284 4.06375555436097e-30 8.92054105293326e-28 DOWN ENSG00000088538 DOCK3 dedicator of cytokinesis 3 [Source:HGNC Symbol;Acc:HGNC:2989] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0019222|GO:0005737|GO:0019904|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0051345|GO:0017124|GO:0035556|GO:0043087|GO:0043547|GO:0007264 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|cytoplasm|protein domain specific binding|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|positive regulation of hydrolase activity|SH3 domain binding|intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase mediated signal transduction - - - - 3:50675241-51384198 18 27 31 314 385 567 0.145433511595188 0.198262430701627 0.225823670784837 2.27309497846095 2.55222095671648 4.29340288423108 0.189839871027217 3.03957293980284 -4.00101370853527 4.49352979759028e-30 9.79195902023797e-28 DOWN ENSG00000115652 UXS1 UDP-glucuronate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:17729] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0048037|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0042802|GO:0016830|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0031982|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0046983|GO:0006139|GO:0070062|GO:0050662|GO:0000166|GO:0016021|GO:0044249|GO:0005794|GO:0009225|GO:0070403|GO:0016831|GO:0005739|GO:0006461|GO:0005795|GO:1901137|GO:0000139|GO:0042803|GO:0051287|GO:0051259|GO:0031985|GO:0032580|GO:0048040|GO:0033320|GO:0051262 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|cofactor binding|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|identical protein binding|carbon-carbon lyase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|vesicle|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|nucleobase-containing compound metabolic process|extracellular exosome|coenzyme binding|nucleotide binding|integral component of membrane|cellular biosynthetic process|Golgi apparatus|nucleotide-sugar metabolic process|NAD+ binding|carboxy-lyase activity|mitochondrion|protein complex assembly|Golgi stack|carbohydrate derivative biosynthetic process|Golgi membrane|protein homodimerization activity|NAD binding|protein oligomerization|Golgi cisterna|Golgi cisterna membrane|UDP-glucuronate decarboxylase activity|UDP-D-xylose biosynthetic process|protein tetramerization K08678 UDP-glucuronate decarboxylase[4.1.1.35] hsa01100|hsa00500|hsa00520 Metabolic pathways - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Amino sugar and nucleotide sugar metabolism - Homo sapiens (human) 2:106093303-106194339 163 163 310 1570 1650 1407 1.08713313017316 0.988012508348689 1.86410165304085 9.38191631583105 9.02913456864888 8.7946209246668 1.3130824305209 9.06855726971558 -2.78791556230515 8.98522531575889e-30 1.94380374330917e-27 DOWN ENSG00000137996 RTCA RNA 3'-terminal phosphate cyclase [Source:HGNC Symbol;Acc:HGNC:17981] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016874|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0043231|GO:0003963|GO:0006139|GO:0000166|GO:0003723|GO:0035639|GO:0001883|GO:0032549|GO:0031981|GO:0005654|GO:0010467|GO:0017076|GO:0016070|GO:0005634|GO:0006396|GO:0005524|GO:0030554|GO:0044822 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|ligase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA-3'-phosphate cyclase activity|nucleobase-containing compound metabolic process|nucleotide binding|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|nuclear lumen|nucleoplasm|gene expression|purine nucleotide binding|RNA metabolic process|nucleus|RNA processing|ATP binding|adenyl nucleotide binding|poly(A) RNA binding - - - - 1:100266207-100292769 116 107 153 912 967 736 1.88415404539163 1.57951130817872 2.24059892910656 13.2724257247008 12.8870044710824 11.203775787666 1.90142142755897 12.4544019944831 -2.71150552255844 9.33192180215172e-30 2.00428196749236e-27 DOWN ENSG00000157193 LRP8 LDL receptor related protein 8 [Source:HGNC Symbol;Acc:HGNC:6700] GO:0032502|GO:0032991|GO:0004871|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0009892|GO:0048523|GO:0051606|GO:0044877|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0038023|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0044255|GO:0021541|GO:0050817|GO:0050804|GO:0045595|GO:0006725|GO:0034185|GO:0048468|GO:0043025|GO:0009314|GO:0006810|GO:0021766|GO:0051130|GO:1901360|GO:0044853|GO:0007275|GO:0048513|GO:0016358|GO:0034641|GO:0030900|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0009582|GO:0045597|GO:0043169|GO:0004888|GO:0007267|GO:0009611|GO:0060322|GO:0021987|GO:0043235|GO:0043005|GO:0009890|GO:0036477|GO:0014069|GO:0042493|GO:0010646|GO:0006139|GO:0043085|GO:0005875|GO:0007154|GO:0060996|GO:0006629|GO:0007165|GO:0008092|GO:0021543|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:0021537|GO:0044249|GO:0019538|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0050878|GO:0038024|GO:0051090|GO:0016192|GO:0005901|GO:0032268|GO:0000902|GO:0060998|GO:0031175|GO:0031344|GO:0010468|GO:0034645|GO:0046872|GO:0007166|GO:0033993|GO:0060997|GO:0030424|GO:0043412|GO:0009583|GO:0038025|GO:0050773|GO:0034097|GO:0007417|GO:0010629|GO:0010720|GO:0097061|GO:0048813|GO:0006720|GO:0007596|GO:0051252|GO:0071813|GO:0021761|GO:0031346|GO:0000904|GO:0010628|GO:0051347|GO:0036211|GO:0042060|GO:0007602|GO:0060999|GO:0051091|GO:0050769|GO:0007599|GO:0030425|GO:0051247|GO:0070848|GO:0006508|GO:0022604|GO:0032270|GO:0014070|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0019894|GO:0032990|GO:0007399|GO:0071310|GO:0031328|GO:0051246|GO:0010770|GO:0009059|GO:0030154|GO:0048858|GO:1900006|GO:0045121|GO:0016070|GO:0005856|GO:0010557|GO:0009416|GO:0097305|GO:0051960|GO:0048666|GO:0030182|GO:0045893|GO:0010975|GO:0019221|GO:0031401|GO:0061003|GO:0010769|GO:0045892|GO:0032774|GO:2001141|GO:0071363|GO:0016310|GO:0050775|GO:1902679|GO:0008035|GO:0038026|GO:0005509|GO:0071407|GO:0015630|GO:0030229|GO:0009584|GO:0048814|GO:0032793|GO:0071345|GO:0007603|GO:0006897|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0071396|GO:0010976|GO:0061001|GO:0043549|GO:0006351|GO:0006355|GO:0033674|GO:0045666|GO:0006366|GO:0045859|GO:1903507|GO:0045860|GO:0006357|GO:0006468|GO:0070723|GO:0048699|GO:1903506|GO:0042325|GO:0001932|GO:0018193|GO:0006898|GO:0016101|GO:0001934|GO:0000122|GO:0036315|GO:0045664|GO:0042327|GO:0007268|GO:0050731|GO:0050730|GO:0061097|GO:0001523|GO:0071397|GO:0061098|GO:0018108 developmental process|macromolecular complex|signal transducer activity|synapse|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|detection of stimulus|macromolecular complex binding|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|signaling receptor activity|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|cellular lipid metabolic process|ammon gyrus development|coagulation|modulation of synaptic transmission|regulation of cell differentiation|cellular aromatic compound metabolic process|apolipoprotein binding|cell development|neuronal cell body|response to radiation|transport|hippocampus development|positive regulation of cellular component organization|organic cyclic compound metabolic process|plasma membrane raft|multicellular organism development|animal organ development|dendrite development|cellular nitrogen compound metabolic process|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|detection of abiotic stimulus|positive regulation of cell differentiation|cation binding|transmembrane signaling receptor activity|cell-cell signaling|response to wounding|head development|cerebral cortex development|receptor complex|neuron projection|negative regulation of biosynthetic process|somatodendritic compartment|postsynaptic density|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|microtubule associated complex|cell communication|dendritic spine development|lipid metabolic process|signal transduction|cytoskeletal protein binding|pallium development|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|telencephalon development|cellular biosynthetic process|protein metabolic process|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|cargo receptor activity|regulation of sequence-specific DNA binding transcription factor activity|vesicle-mediated transport|caveola|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|neuron projection development|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|response to lipid|dendritic spine morphogenesis|axon|macromolecule modification|detection of light stimulus|reelin receptor activity|regulation of dendrite development|response to cytokine|central nervous system development|negative regulation of gene expression|positive regulation of cell development|dendritic spine organization|dendrite morphogenesis|isoprenoid metabolic process|blood coagulation|regulation of RNA metabolic process|lipoprotein particle binding|limbic system development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|wound healing|phototransduction|positive regulation of dendritic spine development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of neurogenesis|hemostasis|dendrite|positive regulation of protein metabolic process|response to growth factor|proteolysis|regulation of cell morphogenesis|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|kinesin binding|cell part morphogenesis|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of dendrite development|membrane raft|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|response to light stimulus|response to alcohol|regulation of nervous system development|neuron development|neuron differentiation|positive regulation of transcription, DNA-templated|regulation of neuron projection development|cytokine-mediated signaling pathway|positive regulation of protein modification process|positive regulation of dendritic spine morphogenesis|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|phosphorylation|positive regulation of dendrite morphogenesis|negative regulation of RNA biosynthetic process|high-density lipoprotein particle binding|reelin-mediated signaling pathway|calcium ion binding|cellular response to organic cyclic compound|microtubule cytoskeleton|very-low-density lipoprotein particle receptor activity|detection of visible light|regulation of dendrite morphogenesis|positive regulation of CREB transcription factor activity|cellular response to cytokine stimulus|phototransduction, visible light|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|cellular response to lipid|positive regulation of neuron projection development|regulation of dendritic spine morphogenesis|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of kinase activity|positive regulation of neuron differentiation|transcription from RNA polymerase II promoter|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|response to cholesterol|generation of neurons|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|receptor-mediated endocytosis|diterpenoid metabolic process|positive regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|cellular response to sterol|regulation of neuron differentiation|positive regulation of phosphorylation|synaptic transmission|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|retinoid metabolic process|cellular response to cholesterol|positive regulation of protein tyrosine kinase activity|peptidyl-tyrosine phosphorylation - - - - 1:53242364-53328070 280 335 457 2384 2835 1855 1.47324645036974 1.60192477098677 2.16794124936255 11.2388342216559 12.2387850277628 9.14724046742079 1.74770415690635 10.8749532389465 -2.63747629952593 1.07649661612811e-29 2.29555214127775e-27 DOWN ENSG00000186472 PCLO piccolo presynaptic cytomatrix protein [Source:HGNC Symbol;Acc:HGNC:13406] GO:0032502|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048786|GO:0050794|GO:0060076|GO:0043229|GO:0016079|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0031224|GO:0005622|GO:0007269|GO:0005515|GO:0048856|GO:0060341|GO:0051640|GO:0006810|GO:0005938|GO:0007275|GO:0060627|GO:0043168|GO:0032940|GO:0005543|GO:0031982|GO:0022607|GO:0043169|GO:0005737|GO:0007267|GO:0051656|GO:0045184|GO:0014069|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0050808|GO:0051649|GO:0005522|GO:0001505|GO:0048788|GO:0010817|GO:0016021|GO:0006996|GO:0016192|GO:0006836|GO:0051650|GO:0007416|GO:0046872|GO:0007010|GO:0015031|GO:0048489|GO:0006887|GO:0046907|GO:0042886|GO:0017157|GO:0051046|GO:0009914|GO:0009306|GO:0005544|GO:0035556|GO:0007399|GO:0046903|GO:0051648|GO:0005856|GO:0002790|GO:0030073|GO:0045055|GO:0015833|GO:0005509|GO:0016482|GO:0030863|GO:0019932|GO:0046879|GO:0030072|GO:0019935|GO:0017156|GO:0007268|GO:0019933 developmental process|synapse|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|presynaptic active zone|regulation of cellular process|excitatory synapse|intracellular organelle|synaptic vesicle exocytosis|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|intrinsic component of membrane|intracellular|neurotransmitter secretion|protein binding|anatomical structure development|regulation of cellular localization|organelle localization|transport|cell cortex|multicellular organism development|regulation of vesicle-mediated transport|anion binding|secretion by cell|phospholipid binding|vesicle|cellular component assembly|cation binding|cytoplasm|cell-cell signaling|establishment of organelle localization|establishment of protein localization|postsynaptic density|protein localization|cell communication|signal transduction|extracellular exosome|synapse organization|establishment of localization in cell|profilin binding|regulation of neurotransmitter levels|cytoskeleton of presynaptic active zone|regulation of hormone levels|integral component of membrane|organelle organization|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|synapse assembly|metal ion binding|cytoskeleton organization|protein transport|synaptic vesicle transport|exocytosis|intracellular transport|amide transport|regulation of exocytosis|regulation of secretion|hormone transport|protein secretion|calcium-dependent phospholipid binding|intracellular signal transduction|nervous system development|secretion|vesicle localization|cytoskeleton|peptide secretion|insulin secretion|regulated exocytosis|peptide transport|calcium ion binding|cytosolic transport|cortical cytoskeleton|second-messenger-mediated signaling|hormone secretion|peptide hormone secretion|cyclic-nucleotide-mediated signaling|calcium ion regulated exocytosis|synaptic transmission|cAMP-mediated signaling K16882 protein piccolo[-] hsa04911 Insulin secretion - Homo sapiens (human) 7:82754013-83162930 17 17 29 262 296 393 0.0420088629028211 0.0381804213101153 0.0646124064184392 0.580094543898071 0.600149374054319 0.910167395771588 0.0482672302104585 0.696803771241326 -3.85163648613528 1.66847877191871e-29 3.53267838701143e-27 DOWN ENSG00000152217 SETBP1 SET binding protein 1 [Source:HGNC Symbol;Acc:HGNC:15573] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0003677|GO:0005634 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|DNA binding|nucleus - - - - 18:44680173-45068510 12 13 20 210 205 225 0.0723426807846325 0.0712259546348878 0.108706412130072 1.1342705147393 1.0139634375393 1.27119453402484 0.0840916825165308 1.13980949543448 -3.76068579530947 2.52591963813012e-29 5.3104792166716e-27 DOWN ENSG00000163812 ZDHHC3 zinc finger, DHHC-type containing 3 [Source:HGNC Symbol;Acc:HGNC:18470] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006810|GO:0043231|GO:0043169|GO:0016746|GO:0005737|GO:0045184|GO:0008104|GO:0051649|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0015031|GO:0036211|GO:0046907|GO:0042157|GO:0016747|GO:0034613|GO:0044267|GO:0000139|GO:0009059|GO:0016409|GO:0006605|GO:0006886|GO:0042158|GO:0046914|GO:0006464|GO:0019706|GO:0006497|GO:0008270|GO:0018345 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|transport|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|cytoplasm|establishment of protein localization|protein localization|establishment of localization in cell|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|protein transport|protein modification process|intracellular transport|lipoprotein metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein localization|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|palmitoyltransferase activity|protein targeting|intracellular protein transport|lipoprotein biosynthetic process|transition metal ion binding|cellular protein modification process|protein-cysteine S-palmitoyltransferase activity|protein lipidation|zinc ion binding|protein palmitoylation - - - - 3:44915257-44976185 279 292 437 1886 2043 1881 1.60412570798571 1.52579795229524 2.26532616962119 9.71569930660257 9.63764683787872 10.135669493138 1.79841660996738 9.82967187920643 -2.45041599398051 2.68957160756002e-29 5.61499795609068e-27 DOWN ENSG00000229152 ANKRD10-IT1 ANKRD10 intronic transcript 1 [Source:HGNC Symbol;Acc:HGNC:39891] - - - - - - 13:110894639-110899172 5 3 9 135 133 150 0.442126181519093 0.241115413618848 0.717461367241941 10.6951582124606 9.6488704397871 12.4301638852062 0.466900987459961 10.924730845818 -4.54833728627773 3.57230410654508e-29 7.40608102755534e-27 DOWN ENSG00000167522 ANKRD11 ankyrin repeat domain 11 [Source:HGNC Symbol;Acc:HGNC:21316] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0009653|GO:0043227|GO:0071944|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0007275|GO:0048513|GO:0060325|GO:0043231|GO:0005737|GO:0060322|GO:0009887|GO:0035264|GO:0042592|GO:0048871|GO:0010171|GO:0060323|GO:0060348|GO:0060324|GO:0048705|GO:0001894|GO:0009790|GO:0031981|GO:0005654|GO:0042476|GO:0001501|GO:0005634|GO:0009792|GO:0042475|GO:0043009|GO:0001701 developmental process|growth|cell|membrane|binding|intracellular organelle|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|multicellular organism development|animal organ development|face morphogenesis|intracellular membrane-bounded organelle|cytoplasm|head development|organ morphogenesis|multicellular organism growth|homeostatic process|multicellular organismal homeostasis|body morphogenesis|head morphogenesis|bone development|face development|skeletal system morphogenesis|tissue homeostasis|embryo development|nuclear lumen|nucleoplasm|odontogenesis|skeletal system development|nucleus|embryo development ending in birth or egg hatching|odontogenesis of dentin-containing tooth|chordate embryonic development|in utero embryonic development - - - - 16:89267627-89490561 209 188 197 1082 1290 1148 0.642168812272171 0.524976665401141 0.54573781060554 2.97870620558429 3.25207402110189 3.30577821091456 0.570961096092951 3.17885281253358 -2.47704186595346 3.620427457325e-29 7.45408560765383e-27 DOWN ENSG00000196562 SULF2 sulfatase 2 [Source:HGNC Symbol;Acc:HGNC:20392] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0009986|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0016787|GO:0005615|GO:0050793|GO:0005622|GO:1903829|GO:0005886|GO:0012505|GO:0048856|GO:0060341|GO:0042127|GO:0003014|GO:0001822|GO:0009888|GO:0048468|GO:0006810|GO:0006082|GO:0032835|GO:0007275|GO:0048513|GO:0016788|GO:0043062|GO:0044281|GO:0032836|GO:0090287|GO:0001817|GO:0043231|GO:0043169|GO:0005737|GO:0003012|GO:0001816|GO:0009611|GO:0032880|GO:0051222|GO:0009887|GO:0009966|GO:0072006|GO:0050673|GO:0045184|GO:0060384|GO:0001819|GO:0032388|GO:0010646|GO:0090288|GO:1900182|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0009968|GO:0051649|GO:0021675|GO:0090316|GO:0060348|GO:0048869|GO:0009967|GO:0019538|GO:0010033|GO:0048732|GO:0005794|GO:0006790|GO:0071774|GO:0030111|GO:0042307|GO:0010574|GO:0040036|GO:0006936|GO:0051216|GO:0046872|GO:0007166|GO:0072594|GO:0097205|GO:0001655|GO:0002063|GO:0031100|GO:0032386|GO:0051223|GO:0008484|GO:0015031|GO:0022612|GO:0009790|GO:0001889|GO:0009100|GO:0010575|GO:0070201|GO:0046907|GO:2000027|GO:0072001|GO:0030201|GO:0044344|GO:0070848|GO:0050678|GO:1904591|GO:0034613|GO:0005795|GO:0017038|GO:0007399|GO:0071310|GO:0030198|GO:0030177|GO:0040037|GO:0030154|GO:0001501|GO:0061448|GO:1903827|GO:0006606|GO:0010573|GO:0016055|GO:1904589|GO:0048706|GO:0097421|GO:0033365|GO:0033157|GO:0009792|GO:0008543|GO:0006939|GO:0051169|GO:0060828|GO:0002062|GO:0072576|GO:0071363|GO:0006605|GO:0004065|GO:0005509|GO:0016482|GO:0006886|GO:0007167|GO:0006029|GO:0072574|GO:0042306|GO:1900180|GO:0035413|GO:0008449|GO:2000345|GO:0090263|GO:0003094|GO:0035411|GO:0046824|GO:1903533|GO:0006913|GO:0035412|GO:0060070|GO:0043009|GO:0034504|GO:0046822|GO:0007169|GO:0051170|GO:0035860|GO:0014846 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|cell surface|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|hydrolase activity|extracellular space|regulation of developmental process|intracellular|positive regulation of cellular protein localization|plasma membrane|endomembrane system|anatomical structure development|regulation of cellular localization|regulation of cell proliferation|renal system process|kidney development|tissue development|cell development|transport|organic acid metabolic process|glomerulus development|multicellular organism development|animal organ development|hydrolase activity, acting on ester bonds|extracellular structure organization|small molecule metabolic process|glomerular basement membrane development|regulation of cellular response to growth factor stimulus|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|cytoplasm|muscle system process|cytokine production|response to wounding|regulation of protein localization|positive regulation of protein transport|organ morphogenesis|regulation of signal transduction|nephron development|epithelial cell proliferation|establishment of protein localization|innervation|positive regulation of cytokine production|positive regulation of intracellular transport|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|positive regulation of protein localization to nucleus|protein localization|cell communication|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|establishment of localization in cell|nerve development|positive regulation of intracellular protein transport|bone development|cellular developmental process|positive regulation of signal transduction|protein metabolic process|response to organic substance|gland development|Golgi apparatus|sulfur compound metabolic process|response to fibroblast growth factor|regulation of Wnt signaling pathway|positive regulation of protein import into nucleus|regulation of vascular endothelial growth factor production|regulation of fibroblast growth factor receptor signaling pathway|muscle contraction|cartilage development|metal ion binding|cell surface receptor signaling pathway|establishment of protein localization to organelle|renal filtration|urogenital system development|chondrocyte development|organ regeneration|regulation of intracellular transport|regulation of protein transport|sulfuric ester hydrolase activity|protein transport|gland morphogenesis|embryo development|liver development|glycoprotein metabolic process|positive regulation of vascular endothelial growth factor production|regulation of establishment of protein localization|intracellular transport|regulation of organ morphogenesis|renal system development|heparan sulfate proteoglycan metabolic process|cellular response to fibroblast growth factor stimulus|response to growth factor|regulation of epithelial cell proliferation|positive regulation of protein import|cellular protein localization|Golgi stack|protein import|nervous system development|cellular response to organic substance|extracellular matrix organization|positive regulation of Wnt signaling pathway|negative regulation of fibroblast growth factor receptor signaling pathway|cell differentiation|skeletal system development|connective tissue development|regulation of cellular protein localization|protein import into nucleus|vascular endothelial growth factor production|Wnt signaling pathway|regulation of protein import|embryonic skeletal system development|liver regeneration|protein localization to organelle|regulation of intracellular protein transport|embryo development ending in birth or egg hatching|fibroblast growth factor receptor signaling pathway|smooth muscle contraction|nuclear transport|regulation of canonical Wnt signaling pathway|chondrocyte differentiation|liver morphogenesis|cellular response to growth factor stimulus|protein targeting|arylsulfatase activity|calcium ion binding|cytosolic transport|intracellular protein transport|enzyme linked receptor protein signaling pathway|proteoglycan metabolic process|hepatocyte proliferation|regulation of protein import into nucleus|regulation of protein localization to nucleus|positive regulation of catenin import into nucleus|N-acetylglucosamine-6-sulfatase activity|regulation of hepatocyte proliferation|positive regulation of canonical Wnt signaling pathway|glomerular filtration|catenin import into nucleus|positive regulation of nucleocytoplasmic transport|regulation of protein targeting|nucleocytoplasmic transport|regulation of catenin import into nucleus|canonical Wnt signaling pathway|chordate embryonic development|protein localization to nucleus|regulation of nucleocytoplasmic transport|transmembrane receptor protein tyrosine kinase signaling pathway|nuclear import|glial cell-derived neurotrophic factor receptor signaling pathway|esophagus smooth muscle contraction - - - - 20:47656348-47786616 551 653 999 4320 4529 5290 3.21266199806575 3.46024057717526 5.25161874464641 22.5680885459109 21.6662419003516 28.9066597016468 3.97484043996247 24.3803300493031 -2.61674880332462 4.14448722462645e-29 8.47462476739713e-27 DOWN ENSG00000158019 BRE brain and reproductive organ-expressed (TNFRSF1A modulator) [Source:HGNC Symbol;Acc:HGNC:1106] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0033218|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0007049|GO:0006281|GO:0032182|GO:0042277|GO:0006725|GO:0009314|GO:0022402|GO:1901360|GO:2001022|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0070552|GO:0070531|GO:0006139|GO:0007154|GO:0007165|GO:0008219|GO:0000151|GO:0031323|GO:0006996|GO:0051276|GO:0005126|GO:0000075|GO:0000725|GO:0043130|GO:0006325|GO:0006302|GO:0005048|GO:0045739|GO:0031981|GO:2001020|GO:1990234|GO:0005654|GO:0006259|GO:0006282|GO:0012501|GO:0051054|GO:0010212|GO:0005634|GO:0000152|GO:0006974|GO:0006303|GO:0000724|GO:0032813|GO:0000268|GO:0000077|GO:0006310|GO:0016568|GO:0031593|GO:0006915|GO:0005164|GO:0031572 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|amide binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|protein complex|regulation of metabolic process|cell cycle|DNA repair|ubiquitin-like protein binding|peptide binding|cellular aromatic compound metabolic process|response to radiation|cell cycle process|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|BRISC complex|BRCA1-A complex|nucleobase-containing compound metabolic process|cell communication|signal transduction|cell death|ubiquitin ligase complex|regulation of cellular metabolic process|organelle organization|chromosome organization|cytokine receptor binding|cell cycle checkpoint|recombinational repair|ubiquitin binding|chromatin organization|double-strand break repair|signal sequence binding|positive regulation of DNA repair|nuclear lumen|regulation of response to DNA damage stimulus|transferase complex|nucleoplasm|DNA metabolic process|regulation of DNA repair|programmed cell death|positive regulation of DNA metabolic process|response to ionizing radiation|nucleus|nuclear ubiquitin ligase complex|cellular response to DNA damage stimulus|double-strand break repair via nonhomologous end joining|double-strand break repair via homologous recombination|tumor necrosis factor receptor superfamily binding|peroxisome targeting sequence binding|DNA damage checkpoint|DNA recombination|chromatin modification|polyubiquitin binding|apoptotic process|tumor necrosis factor receptor binding|G2 DNA damage checkpoint - - - - 2:27889941-28338901 101 79 86 692 771 640 1.56333791969007 1.11131888159833 1.2001704540503 9.59695301642288 9.79156502837853 9.28407796822103 1.2916090851129 9.55753200434081 -2.8874686321309 4.48782412685875e-29 9.11425180158102e-27 DOWN ENSG00000112893 MAN2A1 mannosidase, alpha, class 2A, member 1 [Source:HGNC Symbol;Acc:HGNC:6824] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0030246|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0012505|GO:0048856|GO:0031090|GO:0006486|GO:0007585|GO:0048286|GO:0045595|GO:0060041|GO:0009888|GO:0048468|GO:0035295|GO:0007275|GO:0030324|GO:0048513|GO:0016798|GO:0044281|GO:0031982|GO:0045597|GO:0043231|GO:0043169|GO:0005737|GO:0007423|GO:0005975|GO:0009887|GO:0048729|GO:0030323|GO:0070062|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0048732|GO:0005794|GO:0006996|GO:0009311|GO:0034645|GO:0046872|GO:0001654|GO:0043412|GO:0006487|GO:0010720|GO:0007005|GO:0060541|GO:0005801|GO:0009790|GO:0001889|GO:0009100|GO:0036211|GO:0050769|GO:0060042|GO:0005996|GO:0070085|GO:0004553|GO:1901137|GO:0044267|GO:0007399|GO:0000139|GO:0016799|GO:0009059|GO:0030154|GO:0051960|GO:0007033|GO:0019318|GO:0009101|GO:0043413|GO:0009792|GO:0006491|GO:0043010|GO:0018279|GO:0046914|GO:0022008|GO:0006464|GO:0015923|GO:0050767|GO:0048592|GO:0048593|GO:0048699|GO:0018193|GO:0006517|GO:0043009|GO:0043687|GO:0006013|GO:0008270|GO:0004559|GO:0001701|GO:0004572 developmental process|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|carbohydrate binding|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|endomembrane system|anatomical structure development|organelle membrane|protein glycosylation|respiratory gaseous exchange|lung alveolus development|regulation of cell differentiation|retina development in camera-type eye|tissue development|cell development|tube development|multicellular organism development|lung development|animal organ development|hydrolase activity, acting on glycosyl bonds|small molecule metabolic process|vesicle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|cytoplasm|sensory organ development|carbohydrate metabolic process|organ morphogenesis|tissue morphogenesis|respiratory tube development|extracellular exosome|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|gland development|Golgi apparatus|organelle organization|oligosaccharide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|eye development|macromolecule modification|protein N-linked glycosylation|positive regulation of cell development|mitochondrion organization|respiratory system development|cis-Golgi network|embryo development|liver development|glycoprotein metabolic process|protein modification process|positive regulation of neurogenesis|retina morphogenesis in camera-type eye|monosaccharide metabolic process|glycosylation|hydrolase activity, hydrolyzing O-glycosyl compounds|carbohydrate derivative biosynthetic process|cellular protein metabolic process|nervous system development|Golgi membrane|hydrolase activity, hydrolyzing N-glycosyl compounds|macromolecule biosynthetic process|cell differentiation|regulation of nervous system development|vacuole organization|hexose metabolic process|glycoprotein biosynthetic process|macromolecule glycosylation|embryo development ending in birth or egg hatching|N-glycan processing|camera-type eye development|protein N-linked glycosylation via asparagine|transition metal ion binding|neurogenesis|cellular protein modification process|mannosidase activity|regulation of neurogenesis|eye morphogenesis|camera-type eye morphogenesis|generation of neurons|peptidyl-amino acid modification|protein deglycosylation|chordate embryonic development|post-translational protein modification|mannose metabolic process|zinc ion binding|alpha-mannosidase activity|in utero embryonic development|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity K01231 alpha-mannosidase II[3.2.1.114] hsa01100|hsa00510 Metabolic pathways - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 5:109689366-109869625 149 157 290 1249 1476 1520 0.788611884503803 0.755191683581876 1.38385094205543 5.9229348297895 6.40960409551685 7.53961507463176 0.975884836713703 6.6240513333127 -2.76293104128557 5.72644687884869e-29 1.15511719676452e-26 DOWN ENSG00000060762 MPC1 mitochondrial pyruvate carrier 1 [Source:HGNC Symbol;Acc:HGNC:21606] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0022857|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0006725|GO:0019866|GO:0006810|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0031966|GO:0051186|GO:0022891|GO:0006139|GO:0055086|GO:0055085|GO:0051649|GO:0016021|GO:0044249|GO:0006790|GO:0005740|GO:0006086|GO:0006637|GO:1903825|GO:0046907|GO:0006811|GO:0015075|GO:0005743|GO:0005739|GO:0006796|GO:0034220|GO:0006820|GO:0015711|GO:0098656|GO:0009117|GO:0006839|GO:0008509|GO:0009108|GO:0046942|GO:0046943|GO:0019752|GO:1902361|GO:0061732|GO:0006084|GO:1901475|GO:0015718|GO:0006850|GO:0006085|GO:0032787|GO:0008514|GO:0008028|GO:0050833|GO:0006090 transporter activity|cell|membrane|cellular process|metabolic process|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|transport|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|cofactor metabolic process|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|transmembrane transport|establishment of localization in cell|integral component of membrane|cellular biosynthetic process|sulfur compound metabolic process|mitochondrial envelope|acetyl-CoA biosynthetic process from pyruvate|acyl-CoA metabolic process|organic acid transmembrane transport|intracellular transport|ion transport|ion transmembrane transporter activity|mitochondrial inner membrane|mitochondrion|phosphate-containing compound metabolic process|ion transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|nucleotide metabolic process|mitochondrial transport|anion transmembrane transporter activity|coenzyme biosynthetic process|carboxylic acid transport|carboxylic acid transmembrane transporter activity|carboxylic acid metabolic process|mitochondrial pyruvate transmembrane transport|mitochondrial acetyl-CoA biosynthetic process from pyruvate|acetyl-CoA metabolic process|pyruvate transmembrane transport|monocarboxylic acid transport|mitochondrial pyruvate transport|acetyl-CoA biosynthetic process|monocarboxylic acid metabolic process|organic anion transmembrane transporter activity|monocarboxylic acid transmembrane transporter activity|pyruvate transmembrane transporter activity|pyruvate metabolic process - - - - 6:166364919-166383013 9 12 7 164 221 160 0.216837601160741 0.262754640650148 0.152048021049089 3.54023815955745 4.36868248228652 3.61275854178901 0.210546754286659 3.84055972787766 -4.18910404569048 7.10845430986984e-29 1.42426708031446e-26 DOWN ENSG00000112249 ASCC3 activating signal cointegrator 1 complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:18697] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0005737|GO:0006139|GO:0000166|GO:0044249|GO:0031323|GO:0005794|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0003723|GO:0035639|GO:0043412|GO:0051252|GO:0001883|GO:0016818|GO:0032549|GO:0031981|GO:0005654|GO:0006259|GO:0010467|GO:0017076|GO:0009059|GO:0016070|GO:0005634|GO:0006974|GO:0006307|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0006304|GO:0044822|GO:0071103|GO:0016462|GO:0006351|GO:0006355|GO:0032392|GO:1903506|GO:0017111|GO:0016887|GO:0032508|GO:0004386|GO:0003678|GO:0042623|GO:0043138|GO:0008026|GO:0008094|GO:0004003|GO:0043140 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|endomembrane system|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|purine ribonucleoside triphosphate binding|macromolecule modification|regulation of RNA metabolic process|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|nucleoplasm|DNA metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|DNA dealkylation involved in DNA repair|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|DNA modification|poly(A) RNA binding|DNA conformation change|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA geometric change|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|ATPase activity|DNA duplex unwinding|helicase activity|DNA helicase activity|ATPase activity, coupled|3'-5' DNA helicase activity|ATP-dependent helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity - - - - 6:100508194-100881372 237 278 338 1536 1678 1430 1.15490606362823 1.23118420900946 1.48501292284784 6.70637362739624 6.70901585500583 6.53076145087867 1.29036773182851 6.64871697776025 -2.36529369977386 7.96390059162802e-29 1.58502858841642e-26 DOWN ENSG00000182446 NPLOC4 NPL4 homolog, ubiquitin recognition factor [Source:HGNC Symbol;Acc:HGNC:18261] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006281|GO:0032182|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0034098|GO:0045184|GO:0036501|GO:0006139|GO:0008104|GO:0005783|GO:0051649|GO:0044249|GO:0019538|GO:0010033|GO:0010256|GO:0036503|GO:0006996|GO:0005829|GO:0034645|GO:0046872|GO:0007030|GO:0030163|GO:0030970|GO:0043130|GO:0019985|GO:0015031|GO:0044265|GO:0046907|GO:0030433|GO:0031981|GO:0006508|GO:0005654|GO:0006259|GO:0034613|GO:0006301|GO:0044267|GO:0009059|GO:0034976|GO:0005634|GO:0006974|GO:0044389|GO:0031625|GO:0044257|GO:0010498|GO:0032527|GO:0070987|GO:0006886|GO:0051603|GO:0046914|GO:0071897|GO:0019941|GO:0008270|GO:0043161|GO:0006511 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|DNA repair|ubiquitin-like protein binding|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|VCP-NPL4-UFD1 AAA ATPase complex|establishment of protein localization|UFD1-NPL4 complex|nucleobase-containing compound metabolic process|protein localization|endoplasmic reticulum|establishment of localization in cell|cellular biosynthetic process|protein metabolic process|response to organic substance|endomembrane system organization|ERAD pathway|organelle organization|cytosol|cellular macromolecule biosynthetic process|metal ion binding|Golgi organization|protein catabolic process|retrograde protein transport, ER to cytosol|ubiquitin binding|translesion synthesis|protein transport|cellular macromolecule catabolic process|intracellular transport|ER-associated ubiquitin-dependent protein catabolic process|nuclear lumen|proteolysis|nucleoplasm|DNA metabolic process|cellular protein localization|postreplication repair|cellular protein metabolic process|macromolecule biosynthetic process|response to endoplasmic reticulum stress|nucleus|cellular response to DNA damage stimulus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|proteasomal protein catabolic process|protein exit from endoplasmic reticulum|error-free translesion synthesis|intracellular protein transport|proteolysis involved in cellular protein catabolic process|transition metal ion binding|DNA biosynthetic process|modification-dependent protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process K14015 nuclear protein localization protein 4 homolog[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 17:81556887-81648465 601 839 808 4135 4242 3694 2.82514792861774 3.58433929547534 3.42446378563728 17.4156704728273 16.3608391457751 16.2739426321415 3.27798366991012 16.6834840835813 -2.34754003201895 9.66452545347938e-29 1.91075988667664e-26 DOWN ENSG00000143499 SMYD2 SET and MYND domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20982] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0007507|GO:0042127|GO:0006725|GO:1901360|GO:0007275|GO:0016570|GO:0048513|GO:0002039|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0032403|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0008285|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005829|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0072358|GO:0010629|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0070063|GO:0031981|GO:2001020|GO:0005654|GO:0035556|GO:0044267|GO:0010467|GO:0000993|GO:0009059|GO:1902531|GO:0016070|GO:0072359|GO:0005634|GO:0006974|GO:0045892|GO:0072331|GO:0042770|GO:0032774|GO:2001141|GO:0043175|GO:1902679|GO:0018022|GO:0008276|GO:1901796|GO:0034968|GO:0016568|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0043516|GO:0006366|GO:1903507|GO:0006357|GO:0016279|GO:1903506|GO:0018193|GO:0042054|GO:0018027|GO:0000122|GO:0018026|GO:0010452|GO:0030330|GO:0018024|GO:0018205|GO:0046975 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|methylation|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|heart development|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|histone modification|animal organ development|p53 binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|protein complex binding|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of cell proliferation|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|cytosol|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|cardiovascular system development|negative regulation of gene expression|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|protein modification process|RNA polymerase binding|nuclear lumen|regulation of response to DNA damage stimulus|nucleoplasm|intracellular signal transduction|cellular protein metabolic process|gene expression|RNA polymerase II core binding|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|nucleus|cellular response to DNA damage stimulus|negative regulation of transcription, DNA-templated|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|regulation of RNA biosynthetic process|RNA polymerase core enzyme binding|negative regulation of RNA biosynthetic process|peptidyl-lysine methylation|protein methyltransferase activity|regulation of signal transduction by p53 class mediator|histone lysine methylation|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|regulation of DNA damage response, signal transduction by p53 class mediator|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|protein-lysine N-methyltransferase activity|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone methyltransferase activity|peptidyl-lysine dimethylation|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|histone H3-K36 methylation|DNA damage response, signal transduction by p53 class mediator|histone-lysine N-methyltransferase activity|peptidyl-lysine modification|histone methyltransferase activity (H3-K36 specific) - - - - 1:214281102-214337131 120 155 199 1220 1171 856 0.908727665075815 1.06675540594301 1.35869093028093 8.27770167365855 7.27574009421533 6.07512260305291 1.11139133376659 7.2095214569756 -2.69753660572873 1.02753971835708e-28 2.01816912841001e-26 DOWN ENSG00000033170 FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) [Source:HGNC Symbol;Acc:HGNC:4019] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0048870|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0006486|GO:0007585|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0044281|GO:0031982|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0005975|GO:0071559|GO:0006928|GO:0006979|GO:0019904|GO:0006139|GO:0007154|GO:0016477|GO:0007165|GO:0070062|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0005794|GO:0009311|GO:1902882|GO:0010468|GO:0034645|GO:0007166|GO:0009225|GO:0043412|GO:0006487|GO:0017124|GO:0009790|GO:0033578|GO:0009100|GO:0036211|GO:0071560|GO:0016758|GO:1900407|GO:0034599|GO:0005996|GO:0070848|GO:0070085|GO:0016052|GO:0005795|GO:1901137|GO:0044267|GO:0010467|GO:0071310|GO:0000139|GO:0009059|GO:0016051|GO:0043112|GO:0009312|GO:0019318|GO:0009101|GO:0008417|GO:0043413|GO:0009792|GO:0006491|GO:0036065|GO:0071363|GO:0018279|GO:0007229|GO:0031985|GO:0007179|GO:0007167|GO:0032580|GO:0046368|GO:0006464|GO:0046921|GO:0006004|GO:0036071|GO:0018193|GO:0043009|GO:0043687|GO:0007178|GO:0008424|GO:0001701|GO:0042355 locomotion|developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cell motility|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|protein glycosylation|respiratory gaseous exchange|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|response to transforming growth factor beta|movement of cell or subcellular component|response to oxidative stress|protein domain specific binding|nucleobase-containing compound metabolic process|cell communication|cell migration|signal transduction|extracellular exosome|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|Golgi apparatus|oligosaccharide metabolic process|regulation of response to oxidative stress|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|nucleotide-sugar metabolic process|macromolecule modification|protein N-linked glycosylation|SH3 domain binding|embryo development|protein glycosylation in Golgi|glycoprotein metabolic process|protein modification process|cellular response to transforming growth factor beta stimulus|transferase activity, transferring hexosyl groups|regulation of cellular response to oxidative stress|cellular response to oxidative stress|monosaccharide metabolic process|response to growth factor|glycosylation|carbohydrate catabolic process|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|gene expression|cellular response to organic substance|Golgi membrane|macromolecule biosynthetic process|carbohydrate biosynthetic process|receptor metabolic process|oligosaccharide biosynthetic process|hexose metabolic process|glycoprotein biosynthetic process|fucosyltransferase activity|macromolecule glycosylation|embryo development ending in birth or egg hatching|N-glycan processing|fucosylation|cellular response to growth factor stimulus|protein N-linked glycosylation via asparagine|integrin-mediated signaling pathway|Golgi cisterna|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|Golgi cisterna membrane|GDP-L-fucose metabolic process|cellular protein modification process|alpha-(1->6)-fucosyltransferase activity|fucose metabolic process|N-glycan fucosylation|peptidyl-amino acid modification|chordate embryonic development|post-translational protein modification|transmembrane receptor protein serine/threonine kinase signaling pathway|glycoprotein 6-alpha-L-fucosyltransferase activity|in utero embryonic development|L-fucose catabolic process K00717 glycoprotein 6-alpha-L-fucosyltransferase[2.4.1.68] hsa01100|hsa05202|hsa00510|hsa00533 Metabolic pathways - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human)|Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human) 14:65410592-65744121 282 350 483 2333 2566 1893 1.52017927180819 1.7147199914399 2.34751040301361 11.2682944650443 11.3493339254327 9.56368245963725 1.86080322208723 10.7271036167048 -2.52726318708021 1.04111786104473e-28 2.03147272049865e-26 DOWN ENSG00000092621 PHGDH phosphoglycerate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8923] GO:0032502|GO:0009055|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0016491|GO:0006807|GO:0043209|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0048037|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0007049|GO:0009888|GO:0048468|GO:0022402|GO:0035295|GO:0006082|GO:0007275|GO:0048513|GO:0034641|GO:0044281|GO:0031982|GO:0007420|GO:0016614|GO:0005737|GO:0006520|GO:0060322|GO:0021915|GO:0070062|GO:0050662|GO:0000166|GO:0030030|GO:0048869|GO:0044249|GO:0006790|GO:0055114|GO:0019530|GO:0005829|GO:0031175|GO:0010468|GO:0007417|GO:0021782|GO:0021510|GO:0009790|GO:0016616|GO:0008652|GO:0060429|GO:0070314|GO:0010467|GO:0007399|GO:0030154|GO:0051287|GO:0009448|GO:0048666|GO:0030182|GO:0009792|GO:0010001|GO:0004617|GO:0019752|GO:0009069|GO:0022008|GO:0006563|GO:0006541|GO:0006544|GO:0006566|GO:0048699|GO:0042063|GO:0009070|GO:0043009|GO:0032787|GO:0006564 developmental process|electron carrier activity|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|oxidoreductase activity|nitrogen compound metabolic process|myelin sheath|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|cofactor binding|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cell cycle|tissue development|cell development|cell cycle process|tube development|organic acid metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|brain development|oxidoreductase activity, acting on CH-OH group of donors|cytoplasm|cellular amino acid metabolic process|head development|neural tube development|extracellular exosome|coenzyme binding|nucleotide binding|cell projection organization|cellular developmental process|cellular biosynthetic process|sulfur compound metabolic process|oxidation-reduction process|taurine metabolic process|cytosol|neuron projection development|regulation of gene expression|central nervous system development|glial cell development|spinal cord development|embryo development|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|cellular amino acid biosynthetic process|epithelium development|G1 to G0 transition|gene expression|nervous system development|cell differentiation|NAD binding|gamma-aminobutyric acid metabolic process|neuron development|neuron differentiation|embryo development ending in birth or egg hatching|glial cell differentiation|phosphoglycerate dehydrogenase activity|carboxylic acid metabolic process|serine family amino acid metabolic process|neurogenesis|L-serine metabolic process|glutamine metabolic process|glycine metabolic process|threonine metabolic process|generation of neurons|gliogenesis|serine family amino acid biosynthetic process|chordate embryonic development|monocarboxylic acid metabolic process|L-serine biosynthetic process K00058 D-3-phosphoglycerate dehydrogenase[1.1.1.95] hsa01100|hsa01200|hsa01230|hsa00260 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human) 1:119659798-119744215 543 637 1047 4708 5101 4381 5.31480290521647 5.66639571731356 9.23950717552771 41.2878078751469 40.9648145927048 40.1873955527523 6.74023526601925 40.8133393402013 -2.59816990221431 1.45305106608017e-28 2.81684328095828e-26 DOWN ENSG00000187720 THSD4 thrombospondin type 1 domain containing 4 [Source:HGNC Symbol;Acc:HGNC:25835] GO:0031012|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043205|GO:0005578|GO:0071704|GO:0016043|GO:0043227|GO:0016787|GO:0005515|GO:0043062|GO:0031982|GO:0022607|GO:0008233|GO:0001527|GO:0070062|GO:0019538|GO:0006508|GO:0085029|GO:0030198|GO:0008237|GO:0048251|GO:0004175|GO:0004222 extracellular matrix|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|fibril|proteinaceous extracellular matrix|organic substance metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|protein binding|extracellular structure organization|vesicle|cellular component assembly|peptidase activity|microfibril|extracellular exosome|protein metabolic process|proteolysis|extracellular matrix assembly|extracellular matrix organization|metallopeptidase activity|elastic fiber assembly|endopeptidase activity|metalloendopeptidase activity - - - - 15:71096952-71783383 86 108 101 599 731 790 0.282041423215624 0.321898494345566 0.298642328377937 1.7601131441587 1.96698554125122 2.42812818889075 0.300860748646376 2.05174229143356 -2.76968172800128 1.80272538648385e-28 3.47216539923155e-26 DOWN ENSG00000174010 KLHL15 kelch like family member 15 [Source:HGNC Symbol;Acc:HGNC:29347] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0009056|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0030163|GO:0004842|GO:0031461|GO:0044265|GO:0036211|GO:1990234|GO:0006508|GO:0044267|GO:0044257|GO:0051603|GO:0006464|GO:0031463|GO:0019941|GO:0032446|GO:0006511|GO:0042787|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|catabolic process|cellular metabolic process|intracellular|protein binding|protein complex|transferase activity|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|cellular macromolecule catabolic process|protein modification process|transferase complex|proteolysis|cellular protein metabolic process|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|cellular protein modification process|Cul3-RING ubiquitin ligase complex|modification-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - X:23983720-24027186 952 1042 1277 206 290 223 10.7368409105949 10.6803937525042 12.9850876636895 2.08163373876333 2.68352532379553 2.35707185184018 11.4674407755962 2.37407697146635 2.27210484115076 2.08151842471212e-28 3.9834391699587e-26 UP ENSG00000129636 ITFG1 integrin alpha FG-GAP repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:30697] GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0031224|GO:0005515|GO:0031982|GO:0070062|GO:0016021 membrane|extracellular region|binding|extracellular vesicle|membrane-bounded organelle|intrinsic component of membrane|protein binding|vesicle|extracellular exosome|integral component of membrane - - - - 16:47154387-47464149 240 283 354 1507 1563 1682 1.76126675370333 1.88747140917466 2.34223774993806 9.90888130602672 9.41110601983213 11.5682805849831 1.99699197093868 10.296089303614 -2.36619603456997 2.43655495089869e-28 4.63317907669615e-26 DOWN ENSG00000161040 FBXL13 F-box and leucine-rich repeat protein 13 [Source:HGNC Symbol;Acc:HGNC:21658] GO:0005488|GO:0005515 binding|protein binding - - - - 7:102813230-103074843 55 79 72 587 649 462 0.597437287242218 0.779902839205215 0.705142236955758 5.71303903179931 5.78420772797043 4.7033004892165 0.694160787801064 5.40018241632875 -2.95966636514802 2.87872556359833e-28 5.43933373263699e-26 DOWN ENSG00000100580 TMED8 transmembrane p24 trafficking protein family member 8 [Source:HGNC Symbol;Acc:HGNC:18633] GO:0016020|GO:0031224|GO:0006810|GO:0016021 membrane|intrinsic component of membrane|transport|integral component of membrane - - - - 14:77335021-77377109 423 431 779 3452 3827 3341 3.84400330645878 3.55959116402066 6.38255407406757 28.1067997950165 28.5344388154647 28.454324114416 4.59538284818234 28.3651875749657 -2.6258644396739 2.92468258473848e-28 5.49141345187311e-26 DOWN ENSG00000162695 SLC30A7 solute carrier family 30 (zinc transporter), member 7 [Source:HGNC Symbol;Acc:HGNC:19306] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:1903561|GO:0022857|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0006810|GO:0031982|GO:0043231|GO:0005737|GO:0042592|GO:0019725|GO:0022891|GO:0055085|GO:0070062|GO:2000021|GO:0061088|GO:0051238|GO:0016021|GO:0010035|GO:0019538|GO:0005794|GO:0031410|GO:0048878|GO:0010038|GO:0016023|GO:0006811|GO:0055082|GO:0015075|GO:0048471|GO:0031988|GO:0010043|GO:0044267|GO:0032119|GO:0034220|GO:0098655|GO:0006812|GO:0050801|GO:0006873|GO:0008324|GO:0022890|GO:0030001|GO:0030003|GO:0055065|GO:0006875|GO:0071577|GO:0046873|GO:0006882|GO:0046915|GO:0055069|GO:0006829|GO:0005385 transporter activity|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|extracellular vesicle|transmembrane transporter activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|transport|vesicle|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|transmembrane transport|extracellular exosome|regulation of ion homeostasis|regulation of sequestering of zinc ion|sequestering of metal ion|integral component of membrane|response to inorganic substance|protein metabolic process|Golgi apparatus|cytoplasmic vesicle|chemical homeostasis|response to metal ion|cytoplasmic, membrane-bounded vesicle|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|perinuclear region of cytoplasm|membrane-bounded vesicle|response to zinc ion|cellular protein metabolic process|sequestering of zinc ion|ion transmembrane transport|cation transmembrane transport|cation transport|ion homeostasis|cellular ion homeostasis|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|zinc II ion transmembrane transport|metal ion transmembrane transporter activity|cellular zinc ion homeostasis|transition metal ion transmembrane transporter activity|zinc ion homeostasis|zinc II ion transport|zinc ion transmembrane transporter activity - - - - 1:100896076-100981753 99 95 124 671 722 662 0.81828942581659 0.713639182305383 0.924080182581358 4.96928130864864 4.89642142748121 5.12814486405477 0.81866959690111 4.99794920006154 -2.60998301393849 3.4352758189764e-28 6.40979526873259e-26 DOWN ENSG00000142178 SIK1 salt inducible kinase 1 [Source:HGNC Symbol;Acc:HGNC:11142] GO:0032502|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0042752|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0009605|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0007507|GO:0044262|GO:0051726|GO:0007049|GO:0044255|GO:0045595|GO:0006725|GO:0009888|GO:0009314|GO:0006810|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0046483|GO:0010942|GO:0061061|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0071889|GO:0005975|GO:0009890|GO:0006139|GO:0007154|GO:0044092|GO:0006629|GO:0007165|GO:0008134|GO:0008219|GO:0000166|GO:0045833|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0009649|GO:0051090|GO:0090207|GO:0006109|GO:0090209|GO:0010468|GO:0034645|GO:0046486|GO:0046872|GO:0035639|GO:0043412|GO:0072358|GO:0010629|GO:0042692|GO:0051252|GO:0035051|GO:0048738|GO:0008140|GO:0001883|GO:0051055|GO:0051147|GO:0036211|GO:0000278|GO:0060537|GO:0006811|GO:0032549|GO:0006638|GO:0007346|GO:0005996|GO:0043433|GO:0016301|GO:0043269|GO:0019900|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0010467|GO:0008610|GO:0019216|GO:0017076|GO:0046890|GO:0009059|GO:0030154|GO:0043068|GO:0016070|GO:0072359|GO:0016773|GO:0005634|GO:0016051|GO:0009416|GO:0043067|GO:0043153|GO:0019318|GO:0051153|GO:0010866|GO:0043065|GO:0045892|GO:0000287|GO:0032774|GO:0005524|GO:0006812|GO:2001141|GO:0010868|GO:0030554|GO:0006111|GO:0016310|GO:1902679|GO:0009648|GO:0010906|GO:0051146|GO:0042981|GO:0004672|GO:0032792|GO:0006639|GO:0019901|GO:0014706|GO:0055007|GO:0006464|GO:0045721|GO:0006351|GO:0006915|GO:0006355|GO:0019319|GO:1903507|GO:0006468|GO:2000209|GO:1903506|GO:0006006|GO:0043276|GO:0014902|GO:0004674|GO:0002028|GO:0030001|GO:0010830|GO:2000210|GO:0015672|GO:0006641|GO:0019432|GO:0006814|GO:0046777|GO:0006094 developmental process|signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|regulation of circadian rhythm|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|response to external stimulus|biosynthetic process|regulation of developmental process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|heart development|cellular carbohydrate metabolic process|regulation of cell cycle|cell cycle|cellular lipid metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|response to radiation|transport|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|positive regulation of cell death|muscle structure development|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|14-3-3 protein binding|carbohydrate metabolic process|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|negative regulation of molecular function|lipid metabolic process|signal transduction|transcription factor binding|cell death|nucleotide binding|negative regulation of lipid metabolic process|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|entrainment of circadian clock|regulation of sequence-specific DNA binding transcription factor activity|regulation of triglyceride metabolic process|regulation of carbohydrate metabolic process|negative regulation of triglyceride metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|glycerolipid metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|cardiovascular system development|negative regulation of gene expression|muscle cell differentiation|regulation of RNA metabolic process|cardiocyte differentiation|cardiac muscle tissue development|cAMP response element binding protein binding|purine nucleoside binding|negative regulation of lipid biosynthetic process|regulation of muscle cell differentiation|protein modification process|mitotic cell cycle|muscle tissue development|ion transport|ribonucleoside binding|neutral lipid metabolic process|regulation of mitotic cell cycle|monosaccharide metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|kinase activity|regulation of ion transport|kinase binding|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|purine nucleotide binding|regulation of lipid biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|nucleus|carbohydrate biosynthetic process|response to light stimulus|regulation of programmed cell death|entrainment of circadian clock by photoperiod|hexose metabolic process|regulation of striated muscle cell differentiation|regulation of triglyceride biosynthetic process|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|magnesium ion binding|RNA biosynthetic process|ATP binding|cation transport|regulation of RNA biosynthetic process|negative regulation of triglyceride biosynthetic process|adenyl nucleotide binding|regulation of gluconeogenesis|phosphorylation|negative regulation of RNA biosynthetic process|photoperiodism|regulation of glucose metabolic process|striated muscle cell differentiation|regulation of apoptotic process|protein kinase activity|negative regulation of CREB transcription factor activity|acylglycerol metabolic process|protein kinase binding|striated muscle tissue development|cardiac muscle cell differentiation|cellular protein modification process|negative regulation of gluconeogenesis|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|hexose biosynthetic process|negative regulation of nucleic acid-templated transcription|protein phosphorylation|regulation of anoikis|regulation of nucleic acid-templated transcription|glucose metabolic process|anoikis|myotube differentiation|protein serine/threonine kinase activity|regulation of sodium ion transport|metal ion transport|regulation of myotube differentiation|positive regulation of anoikis|monovalent inorganic cation transport|triglyceride metabolic process|triglyceride biosynthetic process|sodium ion transport|protein autophosphorylation|gluconeogenesis K19008 serine/threonine-protein kinase SIK1[2.7.11.1] hsa04922 Glucagon signaling pathway - Homo sapiens (human) 21:43414515-43427128 930 952 1240 208 256 242 12.8940144150221 11.9956041608369 15.5003361969735 2.58384329963491 2.91215070819513 3.14449144789679 13.4633182576108 2.88016181857561 2.22481225462744 4.19733561555668e-28 7.78305946998939e-26 UP ENSG00000198589 LRBA LPS-responsive vesicle trafficking, beach and anchor containing [Source:HGNC Symbol;Acc:HGNC:1742] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0043231|GO:0005737|GO:0005783|GO:0016021|GO:0005794|GO:0005773|GO:0000323|GO:0005764 cell|membrane|binding|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane|Golgi apparatus|vacuole|lytic vacuole|lysosome - - - - 4:150264531-151015727 138 194 360 1865 2046 2237 0.443794122271734 0.567000209280755 1.04380332713372 5.37376262609083 5.3985315788246 6.74212715184858 0.684865886228736 5.83814045225467 -3.09161551390879 4.76064385377519e-28 8.77310256855583e-26 DOWN ENSG00000170017 ALCAM activated leukocyte cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:400] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0030055|GO:0050794|GO:0016049|GO:0009986|GO:0044297|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0031224|GO:0048589|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0006935|GO:0009897|GO:0048468|GO:0043025|GO:0098797|GO:0007275|GO:0005102|GO:0005924|GO:0005912|GO:0031982|GO:0098609|GO:0005887|GO:0043235|GO:0006928|GO:0043005|GO:0001772|GO:0036477|GO:0031226|GO:0007154|GO:0007165|GO:0048588|GO:0070062|GO:0030030|GO:0048869|GO:0016021|GO:0060560|GO:0000902|GO:0031175|GO:0098742|GO:0030424|GO:0000904|GO:0042101|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:1990138|GO:0005925|GO:0048666|GO:0030182|GO:0007411|GO:0007157|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0048675|GO:0007409|GO:0008045|GO:0048699|GO:0031290|GO:0048846 locomotion|developmental process|growth|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|cell-substrate junction|regulation of cellular process|cell growth|cell surface|cell body|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|intrinsic component of membrane|developmental growth|protein binding|plasma membrane|protein complex|anatomical structure development|chemotaxis|external side of plasma membrane|cell development|neuronal cell body|plasma membrane protein complex|multicellular organism development|receptor binding|cell-substrate adherens junction|adherens junction|vesicle|cell-cell adhesion|integral component of plasma membrane|receptor complex|movement of cell or subcellular component|neuron projection|immunological synapse|somatodendritic compartment|intrinsic component of plasma membrane|cell communication|signal transduction|developmental cell growth|extracellular exosome|cell projection organization|cellular developmental process|integral component of membrane|developmental growth involved in morphogenesis|cell morphogenesis|neuron projection development|cell-cell adhesion via plasma-membrane adhesion molecules|axon|cell morphogenesis involved in differentiation|T cell receptor complex|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|neuron projection extension|focal adhesion|neuron development|neuron differentiation|axon guidance|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axon extension|axonogenesis|motor neuron axon guidance|generation of neurons|retinal ganglion cell axon guidance|axon extension involved in axon guidance K06547 activated leukocyte cell adhesion molecule[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 3:105366909-105576900 391 416 1023 6125 7031 8345 2.20120296070323 2.12841850491115 5.19245882289038 30.8949152441305 32.4764289069333 44.0289696916994 3.17402676283492 35.8001046142544 -3.49557760541881 5.10674303762332e-28 9.35317218682249e-26 DOWN ENSG00000111880 RNGTT RNA guanylyltransferase and 5'-phosphatase [Source:HGNC Symbol;Acc:HGNC:10073] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0016740|GO:0016032|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0016788|GO:0001882|GO:0016772|GO:0046483|GO:0016817|GO:0043231|GO:0006139|GO:0000166|GO:0044249|GO:0019538|GO:0034645|GO:0035639|GO:0043412|GO:0001883|GO:0016818|GO:0036211|GO:0032549|GO:0031981|GO:0005654|GO:0006796|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0042578|GO:0032561|GO:0016311|GO:0006396|GO:0032774|GO:0098507|GO:0016071|GO:0016791|GO:0005525|GO:0006464|GO:0019001|GO:0016462|GO:0006351|GO:0006470|GO:0050355|GO:0006366|GO:0004721|GO:0006397|GO:0008192|GO:0035335|GO:0004484|GO:0006370|GO:0008138|GO:0004651|GO:0004725|GO:0009452 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|transferase activity|viral process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|ribonucleoside binding|nuclear lumen|nucleoplasm|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|phosphoric ester hydrolase activity|guanyl ribonucleotide binding|dephosphorylation|RNA processing|RNA biosynthetic process|polynucleotide 5' dephosphorylation|mRNA metabolic process|phosphatase activity|GTP binding|cellular protein modification process|guanyl nucleotide binding|pyrophosphatase activity|transcription, DNA-templated|protein dephosphorylation|triphosphatase activity|transcription from RNA polymerase II promoter|phosphoprotein phosphatase activity|mRNA processing|RNA guanylyltransferase activity|peptidyl-tyrosine dephosphorylation|mRNA guanylyltransferase activity|7-methylguanosine mRNA capping|protein tyrosine/serine/threonine phosphatase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity|7-methylguanosine RNA capping K13917 mRNA-capping enzyme [EC:2.7.7.50 3.6.1.-][-] hsa03015 mRNA surveillance pathway - Homo sapiens (human) 6:88610272-88963721 60 75 80 578 613 455 0.767766382007344 0.872210217183083 0.922957789983648 6.62679351677308 6.43585645316383 5.45655246949773 0.854311463058025 6.17306747981155 -2.8531535164628 7.20969645062655e-28 1.31242852339637e-25 DOWN ENSG00000112685 EXOC2 exocyst complex component 2 [Source:HGNC Symbol;Acc:HGNC:24968] GO:0040011|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0040012|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0047485|GO:0006810|GO:0000145|GO:0005938|GO:0032940|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0022406|GO:0045184|GO:0008104|GO:0061024|GO:0051649|GO:2000535|GO:0019538|GO:0006996|GO:0051701|GO:0016192|GO:0005829|GO:0048278|GO:0015031|GO:0006887|GO:0046907|GO:0006461|GO:0019900|GO:0044267|GO:0046903|GO:0051020|GO:0006904|GO:0034622|GO:0043623|GO:0048193|GO:0031267|GO:0019901|GO:0030260|GO:0017016|GO:0001927|GO:0006892|GO:0017160|GO:0006893 locomotion|macromolecular complex|cell|membrane|cellular process|metabolic process|binding|regulation of locomotion|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|protein N-terminus binding|transport|exocyst|cell cortex|secretion by cell|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|membrane docking|establishment of protein localization|protein localization|membrane organization|establishment of localization in cell|regulation of entry of bacterium into host cell|protein metabolic process|organelle organization|interaction with host|vesicle-mediated transport|cytosol|vesicle docking|protein transport|exocytosis|intracellular transport|protein complex assembly|kinase binding|cellular protein metabolic process|secretion|GTPase binding|vesicle docking involved in exocytosis|cellular macromolecular complex assembly|cellular protein complex assembly|Golgi vesicle transport|small GTPase binding|protein kinase binding|entry into host cell|Ras GTPase binding|exocyst assembly|post-Golgi vesicle-mediated transport|Ral GTPase binding|Golgi to plasma membrane transport K17637 exocyst complex component 2[-] hsa04014 Ras signaling pathway - Homo sapiens (human) 6:485133-693111 126 157 242 1067 1203 1043 1.75691434992355 1.98957950937745 3.04235917466632 13.3303949408565 13.763039188622 13.6299440152295 2.26295101132244 13.5744593815693 -2.58461748379427 8.64451780088451e-28 1.56408142077337e-25 DOWN ENSG00000197565 COL4A6 collagen, type IV, alpha 6 [Source:HGNC Symbol;Acc:HGNC:2208] GO:0031012|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005604|GO:0051716|GO:0005201|GO:0043229|GO:0005578|GO:0071704|GO:0009056|GO:0016043|GO:0007155|GO:0043227|GO:0005622|GO:0043234|GO:0012505|GO:0005587|GO:0043062|GO:0043231|GO:0010243|GO:0005737|GO:0044236|GO:0005783|GO:0005581|GO:0010033|GO:0030574|GO:0044259|GO:0022617|GO:0071417|GO:0043200|GO:0005788|GO:0071310|GO:0030198|GO:0071230|GO:0032963 extracellular matrix|macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|basement membrane|cellular response to stimulus|extracellular matrix structural constituent|intracellular organelle|proteinaceous extracellular matrix|organic substance metabolic process|catabolic process|cellular component organization|cell adhesion|membrane-bounded organelle|intracellular|protein complex|endomembrane system|collagen type IV trimer|extracellular structure organization|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|multicellular organism metabolic process|endoplasmic reticulum|collagen trimer|response to organic substance|collagen catabolic process|multicellular organismal macromolecule metabolic process|extracellular matrix disassembly|cellular response to organonitrogen compound|response to amino acid|endoplasmic reticulum lumen|cellular response to organic substance|extracellular matrix organization|cellular response to amino acid stimulus|collagen metabolic process K06237 collagen, type IV, alpha[-] hsa05200|hsa04151|hsa04510|hsa04933|hsa05146|hsa04974|hsa05222|hsa04512 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) X:108155607-108439497 30 16 49 457 470 379 0.164310735531851 0.0796435798114682 0.241968596616984 2.24266789075004 2.11211136901372 1.94544876127938 0.161974303986768 2.10007600701438 -3.69660468000075 1.23538721904562e-27 2.22176205044506e-25 DOWN ENSG00000151150 ANK3 ankyrin 3, node of Ranvier (ankyrin G) [Source:HGNC Symbol;Acc:HGNC:494] GO:0040011|GO:0032502|GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0060090|GO:0005200|GO:0051716|GO:0042995|GO:0045178|GO:0045760|GO:0048523|GO:0098900|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0009986|GO:0051051|GO:0051641|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0097060|GO:0019222|GO:0007049|GO:0042391|GO:0006935|GO:0048468|GO:0016323|GO:0044325|GO:0009925|GO:0006810|GO:0022402|GO:0007275|GO:0050877|GO:0044291|GO:0043270|GO:0045211|GO:0022607|GO:0030315|GO:0043231|GO:0051651|GO:0005737|GO:0003254|GO:0006928|GO:0042592|GO:0043005|GO:0098901|GO:0045184|GO:0050839|GO:0042383|GO:0030674|GO:0008104|GO:0007154|GO:0044092|GO:0055085|GO:0061024|GO:0007165|GO:0005783|GO:0050808|GO:0016328|GO:0098902|GO:0051649|GO:0008092|GO:2000021|GO:0044091|GO:0071804|GO:0030030|GO:0043034|GO:0032410|GO:0051301|GO:0048869|GO:0010035|GO:1900827|GO:0043296|GO:0010256|GO:0032411|GO:0034763|GO:0043271|GO:0005794|GO:0006996|GO:0016192|GO:0033270|GO:0000902|GO:0071709|GO:0031175|GO:0010468|GO:0090150|GO:0051899|GO:1903047|GO:0030424|GO:0007010|GO:0043267|GO:0048878|GO:0015031|GO:0014704|GO:0043194|GO:0000904|GO:0005773|GO:0001508|GO:0010628|GO:0010038|GO:0034767|GO:0007009|GO:0000278|GO:0046907|GO:0006811|GO:0044304|GO:0032413|GO:1900825|GO:0043292|GO:0072657|GO:0007016|GO:0019226|GO:0045838|GO:0034766|GO:0032507|GO:0034765|GO:0043269|GO:0034613|GO:0045296|GO:0071241|GO:0010467|GO:0010765|GO:0032990|GO:0007399|GO:0097485|GO:0032414|GO:0071805|GO:0030154|GO:0048858|GO:0005923|GO:0005856|GO:0000910|GO:0022898|GO:0033268|GO:0030507|GO:0034220|GO:0048666|GO:0032026|GO:0030182|GO:0007411|GO:1901380|GO:0098655|GO:0086001|GO:0030016|GO:1901379|GO:0014731|GO:0000323|GO:2001258|GO:1901017|GO:0086010|GO:0072659|GO:0090002|GO:0006812|GO:0006605|GO:0048193|GO:0061564|GO:0006886|GO:0032412|GO:1902307|GO:0050801|GO:2000651|GO:0022008|GO:0048667|GO:0048812|GO:1990778|GO:0006612|GO:0000281|GO:0071248|GO:0019228|GO:0072661|GO:1901016|GO:0043001|GO:0043266|GO:0007409|GO:0005764|GO:0048699|GO:0071286|GO:1903817|GO:0002028|GO:0072660|GO:1902305|GO:0030001|GO:2000649|GO:2001257|GO:0006892|GO:0086012|GO:0015672|GO:1902259|GO:1902260|GO:0006813|GO:0035725|GO:0006814|GO:0055065|GO:0006893|GO:0010960 locomotion|developmental process|synapse|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|binding, bridging|structural constituent of cytoskeleton|cellular response to stimulus|cell projection|basal part of cell|positive regulation of action potential|negative regulation of cellular process|regulation of action potential|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|cell surface|negative regulation of transport|cellular localization|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|synaptic membrane|regulation of metabolic process|cell cycle|regulation of membrane potential|chemotaxis|cell development|basolateral plasma membrane|ion channel binding|basal plasma membrane|transport|cell cycle process|multicellular organism development|neurological system process|cell-cell contact zone|positive regulation of ion transport|postsynaptic membrane|cellular component assembly|T-tubule|intracellular membrane-bounded organelle|maintenance of location in cell|cytoplasm|regulation of membrane depolarization|movement of cell or subcellular component|homeostatic process|neuron projection|regulation of cardiac muscle cell action potential|establishment of protein localization|cell adhesion molecule binding|sarcolemma|protein binding, bridging|protein localization|cell communication|negative regulation of molecular function|transmembrane transport|membrane organization|signal transduction|endoplasmic reticulum|synapse organization|lateral plasma membrane|regulation of membrane depolarization during action potential|establishment of localization in cell|cytoskeletal protein binding|regulation of ion homeostasis|membrane biogenesis|cellular potassium ion transport|cell projection organization|costamere|negative regulation of transporter activity|cell division|cellular developmental process|response to inorganic substance|positive regulation of membrane depolarization during cardiac muscle cell action potential|apical junction complex|endomembrane system organization|positive regulation of transporter activity|negative regulation of transmembrane transport|negative regulation of ion transport|Golgi apparatus|organelle organization|vesicle-mediated transport|paranode region of axon|cell morphogenesis|membrane assembly|neuron projection development|regulation of gene expression|establishment of protein localization to membrane|membrane depolarization|mitotic cell cycle process|axon|cytoskeleton organization|negative regulation of potassium ion transport|chemical homeostasis|protein transport|intercalated disc|axon initial segment|cell morphogenesis involved in differentiation|vacuole|action potential|positive regulation of gene expression|response to metal ion|positive regulation of ion transmembrane transport|plasma membrane organization|mitotic cell cycle|intracellular transport|ion transport|main axon|negative regulation of ion transmembrane transporter activity|regulation of membrane depolarization during cardiac muscle cell action potential|contractile fiber|protein localization to membrane|cytoskeletal anchoring at plasma membrane|transmission of nerve impulse|positive regulation of membrane potential|negative regulation of ion transmembrane transport|maintenance of protein location in cell|regulation of ion transmembrane transport|regulation of ion transport|cellular protein localization|cadherin binding|cellular response to inorganic substance|gene expression|positive regulation of sodium ion transport|cell part morphogenesis|nervous system development|neuron projection guidance|positive regulation of ion transmembrane transporter activity|potassium ion transmembrane transport|cell differentiation|cell projection morphogenesis|bicellular tight junction|cytoskeleton|cytokinesis|regulation of transmembrane transporter activity|node of Ranvier|spectrin binding|ion transmembrane transport|neuron development|response to magnesium ion|neuron differentiation|axon guidance|negative regulation of potassium ion transmembrane transport|cation transmembrane transport|cardiac muscle cell action potential|myofibril|regulation of potassium ion transmembrane transport|spectrin-associated cytoskeleton|lytic vacuole|negative regulation of cation channel activity|negative regulation of potassium ion transmembrane transporter activity|membrane depolarization during action potential|protein localization to plasma membrane|establishment of protein localization to plasma membrane|cation transport|protein targeting|Golgi vesicle transport|axon development|intracellular protein transport|regulation of ion transmembrane transporter activity|positive regulation of sodium ion transmembrane transport|ion homeostasis|positive regulation of sodium ion transmembrane transporter activity|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|protein localization to cell periphery|protein targeting to membrane|mitotic cytokinesis|cellular response to metal ion|neuronal action potential|protein targeting to plasma membrane|regulation of potassium ion transmembrane transporter activity|Golgi to plasma membrane protein transport|regulation of potassium ion transport|axonogenesis|lysosome|generation of neurons|cellular response to magnesium ion|negative regulation of voltage-gated potassium channel activity|regulation of sodium ion transport|maintenance of protein location in plasma membrane|regulation of sodium ion transmembrane transport|metal ion transport|regulation of sodium ion transmembrane transporter activity|regulation of cation channel activity|post-Golgi vesicle-mediated transport|membrane depolarization during cardiac muscle cell action potential|monovalent inorganic cation transport|regulation of delayed rectifier potassium channel activity|negative regulation of delayed rectifier potassium channel activity|potassium ion transport|sodium ion transmembrane transport|sodium ion transport|metal ion homeostasis|Golgi to plasma membrane transport|magnesium ion homeostasis K10380 ankyrin[-] hsa05205 Proteoglycans in cancer - Homo sapiens (human) 10:60026298-60733490 49 52 112 704 771 1158 0.0854353028551228 0.0823993026401679 0.176064618648526 1.09979407237699 1.10296899629504 1.89224929608584 0.114633074714606 1.36500412158596 -3.57381004186499 1.52375212776445e-27 2.72395784564551e-25 DOWN ENSG00000104946 TBC1D17 TBC1 domain family member 17 [Source:HGNC Symbol;Acc:HGNC:25699] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0051641|GO:0006914|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0006810|GO:0008047|GO:0031982|GO:0043231|GO:0005737|GO:0045184|GO:0043085|GO:0008104|GO:0051649|GO:0050790|GO:0016192|GO:0005829|GO:0005096|GO:0031410|GO:0051345|GO:0030695|GO:0015031|GO:0005773|GO:0046907|GO:0042147|GO:0043087|GO:0016482|GO:0043547|GO:0005776|GO:0016197 cell|cellular process|metabolic process|binding|intracellular organelle|cellular localization|autophagy|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|transport|enzyme activator activity|vesicle|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|positive regulation of catalytic activity|protein localization|establishment of localization in cell|regulation of catalytic activity|vesicle-mediated transport|cytosol|GTPase activator activity|cytoplasmic vesicle|positive regulation of hydrolase activity|GTPase regulator activity|protein transport|vacuole|intracellular transport|retrograde transport, endosome to Golgi|regulation of GTPase activity|cytosolic transport|positive regulation of GTPase activity|autophagosome|endosomal transport - - - - 19:49877425-49888749 144 160 212 882 1008 1012 1.43063158583961 1.44465847368695 1.89896253954137 7.85113097908412 8.2166363227867 9.42269182802648 1.59141753302264 8.49681970996577 -2.41661055463585 1.97563517418791e-27 3.51075074346464e-25 DOWN ENSG00000081377 CDC14B cell division cycle 14B [Source:HGNC Symbol;Acc:HGNC:1719] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0016788|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0005635|GO:0006139|GO:0043085|GO:0031965|GO:0050790|GO:0016021|GO:0019538|GO:0031323|GO:0005730|GO:0032268|GO:0000075|GO:0043412|GO:0051347|GO:0036211|GO:0031981|GO:0051351|GO:0051247|GO:0005654|GO:0006259|GO:0032270|GO:0006796|GO:0044267|GO:0051246|GO:0005634|GO:0042578|GO:0006974|GO:0016311|GO:0031401|GO:0000077|GO:0016791|GO:0051438|GO:0051443|GO:0006464|GO:0006470|GO:0004721|GO:0051488|GO:0031572|GO:0032446|GO:0035335|GO:0004722|GO:0031398|GO:0031396|GO:0008138|GO:0004725|GO:0016567 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nuclear membrane|regulation of catalytic activity|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|nucleolus|regulation of cellular protein metabolic process|cell cycle checkpoint|macromolecule modification|positive regulation of transferase activity|protein modification process|nuclear lumen|positive regulation of ligase activity|positive regulation of protein metabolic process|nucleoplasm|DNA metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of protein metabolic process|nucleus|phosphoric ester hydrolase activity|cellular response to DNA damage stimulus|dephosphorylation|positive regulation of protein modification process|DNA damage checkpoint|phosphatase activity|regulation of ubiquitin-protein transferase activity|positive regulation of ubiquitin-protein transferase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|activation of anaphase-promoting complex activity|G2 DNA damage checkpoint|protein modification by small protein conjugation|peptidyl-tyrosine dephosphorylation|protein serine/threonine phosphatase activity|positive regulation of protein ubiquitination|regulation of protein ubiquitination|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein ubiquitination K06639 cell division cycle 14[3.1.3.48] hsa04110 Cell cycle - Homo sapiens (human) 9:96490241-96619830 96 60 116 787 707 888 0.374373082737104 0.212648884985069 0.407853453142817 2.74982258498041 2.26214096095223 3.24544606396195 0.33162514028833 2.75246986996486 -3.05310148547584 2.59322542851679e-27 4.58095573626866e-25 DOWN ENSG00000164171 ITGA2 integrin subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:6137] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0000003|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0014823|GO:0045178|GO:0050840|GO:0030055|GO:0051606|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0048520|GO:0071704|GO:0050900|GO:0043167|GO:0009628|GO:0009986|GO:0044237|GO:0050795|GO:0038023|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0016032|GO:0008284|GO:0051272|GO:0042127|GO:0051969|GO:0050817|GO:0006935|GO:0009897|GO:0051971|GO:0009888|GO:0002685|GO:0048468|GO:0006810|GO:0051130|GO:0009612|GO:0009991|GO:0098797|GO:0007275|GO:0010632|GO:0060627|GO:0048513|GO:0014850|GO:0050877|GO:0005102|GO:0034641|GO:0005924|GO:0043062|GO:0006952|GO:0030155|GO:0001618|GO:0005912|GO:0031325|GO:0051128|GO:2000147|GO:0022607|GO:0045807|GO:0051098|GO:0009582|GO:0005887|GO:0043231|GO:0043169|GO:0010243|GO:0004888|GO:0005737|GO:0003012|GO:0033627|GO:0009611|GO:0050920|GO:0043235|GO:0006928|GO:0009887|GO:0032403|GO:0002687|GO:0043005|GO:0031589|GO:0048729|GO:0046983|GO:0048598|GO:0045184|GO:0050839|GO:0042493|GO:0044236|GO:0010646|GO:0031226|GO:0043085|GO:0008104|GO:0050906|GO:0007154|GO:0001704|GO:0007565|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0043236|GO:0045785|GO:0009725|GO:0044306|GO:0010634|GO:0001666|GO:0006970|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0048732|GO:0050878|GO:0050921|GO:0051701|GO:0007584|GO:0016192|GO:0032268|GO:0000902|GO:0006909|GO:0031175|GO:0009743|GO:0071107|GO:0031344|GO:0044259|GO:0030879|GO:0010468|GO:0006936|GO:0090132|GO:0034645|GO:0045216|GO:0048660|GO:0006518|GO:0051101|GO:0046872|GO:0010712|GO:0007166|GO:0033993|GO:0030424|GO:0043412|GO:0032964|GO:0051345|GO:0050727|GO:0007498|GO:0046982|GO:0007596|GO:0005518|GO:0048659|GO:0031346|GO:0000904|GO:0009790|GO:0090257|GO:0001889|GO:0010628|GO:0030334|GO:0050927|GO:0001667|GO:0048661|GO:0036211|GO:0007369|GO:0007160|GO:0042060|GO:0005178|GO:0006954|GO:0033273|GO:0034329|GO:0043679|GO:0007600|GO:0001707|GO:0033591|GO:0043589|GO:0007599|GO:0019226|GO:0031644|GO:0010324|GO:0051099|GO:0030100|GO:0051247|GO:0050729|GO:0048471|GO:0050766|GO:0038064|GO:0043588|GO:0045987|GO:0008305|GO:0032270|GO:0050982|GO:0014070|GO:0060429|GO:0006796|GO:0043603|GO:0006929|GO:0050974|GO:0044267|GO:0014075|GO:0051174|GO:0010467|GO:0050918|GO:0032990|GO:0007399|GO:0019058|GO:0071310|GO:0097485|GO:0030198|GO:0031328|GO:0051246|GO:0071260|GO:0009059|GO:0030154|GO:0048858|GO:0030335|GO:0010714|GO:0031667|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0097305|GO:0048332|GO:0005925|GO:0006971|GO:0043393|GO:0048666|GO:0030182|GO:0007411|GO:0016311|GO:0043043|GO:0031401|GO:0006939|GO:0019233|GO:0050764|GO:0034666|GO:0050954|GO:0030855|GO:0006937|GO:0034332|GO:0038065|GO:0010922|GO:0050966|GO:0046718|GO:0048333|GO:0014909|GO:0045727|GO:0034284|GO:0007229|GO:0043627|GO:0010608|GO:0014910|GO:0032967|GO:0043388|GO:0071383|GO:0071407|GO:0060100|GO:0061564|GO:0006412|GO:0070365|GO:0014911|GO:0007044|GO:0032092|GO:0006417|GO:0032355|GO:0010631|GO:0048041|GO:0006911|GO:0006897|GO:0098639|GO:0022008|GO:0030260|GO:0048667|GO:0006464|GO:0048812|GO:0071396|GO:0032963|GO:0034333|GO:0010921|GO:0006470|GO:0035304|GO:0010694|GO:0033343|GO:0006940|GO:0007409|GO:0048699|GO:0035307|GO:0071392|GO:0071391|GO:0035306|GO:0035303 locomotion|developmental process|macromolecular complex|signal transducer activity|reproduction|immune system process|behavior|signaling|cell|membrane|cellular process|reproductive process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|response to activity|basal part of cell|extracellular matrix binding|cell-substrate junction|detection of stimulus|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|positive regulation of behavior|organic substance metabolic process|leukocyte migration|ion binding|response to abiotic stimulus|cell surface|cellular metabolic process|regulation of behavior|signaling receptor activity|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|viral process|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|regulation of transmission of nerve impulse|coagulation|chemotaxis|external side of plasma membrane|positive regulation of transmission of nerve impulse|tissue development|regulation of leukocyte migration|cell development|transport|positive regulation of cellular component organization|response to mechanical stimulus|response to extracellular stimulus|plasma membrane protein complex|multicellular organism development|regulation of epithelial cell migration|regulation of vesicle-mediated transport|animal organ development|response to muscle activity|neurological system process|receptor binding|cellular nitrogen compound metabolic process|cell-substrate adherens junction|extracellular structure organization|defense response|regulation of cell adhesion|virus receptor activity|adherens junction|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|positive regulation of endocytosis|regulation of binding|detection of abiotic stimulus|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|transmembrane signaling receptor activity|cytoplasm|muscle system process|cell adhesion mediated by integrin|response to wounding|regulation of chemotaxis|receptor complex|movement of cell or subcellular component|organ morphogenesis|protein complex binding|positive regulation of leukocyte migration|neuron projection|cell-substrate adhesion|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|establishment of protein localization|cell adhesion molecule binding|response to drug|multicellular organism metabolic process|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|detection of stimulus involved in sensory perception|cell communication|formation of primary germ layer|female pregnancy|membrane organization|regulation of cellular component movement|cell migration|signal transduction|laminin binding|positive regulation of cell adhesion|response to hormone|neuron projection terminus|positive regulation of epithelial cell migration|response to hypoxia|response to osmotic stress|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|gland development|regulation of body fluid levels|positive regulation of chemotaxis|interaction with host|response to nutrient|vesicle-mediated transport|regulation of cellular protein metabolic process|cell morphogenesis|phagocytosis|neuron projection development|response to carbohydrate|response to parathyroid hormone|regulation of cell projection organization|multicellular organismal macromolecule metabolic process|mammary gland development|regulation of gene expression|muscle contraction|epithelium migration|cellular macromolecule biosynthetic process|cell-cell junction organization|regulation of smooth muscle cell proliferation|peptide metabolic process|regulation of DNA binding|metal ion binding|regulation of collagen metabolic process|cell surface receptor signaling pathway|response to lipid|axon|macromolecule modification|collagen biosynthetic process|positive regulation of hydrolase activity|regulation of inflammatory response|mesoderm development|protein heterodimerization activity|blood coagulation|collagen binding|smooth muscle cell proliferation|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|embryo development|regulation of muscle system process|liver development|positive regulation of gene expression|regulation of cell migration|positive regulation of positive chemotaxis|ameboidal-type cell migration|positive regulation of smooth muscle cell proliferation|protein modification process|gastrulation|cell-matrix adhesion|wound healing|integrin binding|inflammatory response|response to vitamin|cell junction assembly|axon terminus|sensory perception|mesoderm formation|response to L-ascorbic acid|skin morphogenesis|hemostasis|transmission of nerve impulse|regulation of neurological system process|membrane invagination|positive regulation of binding|regulation of endocytosis|positive regulation of protein metabolic process|positive regulation of inflammatory response|perinuclear region of cytoplasm|positive regulation of phagocytosis|collagen receptor activity|skin development|positive regulation of smooth muscle contraction|integrin complex|positive regulation of cellular protein metabolic process|detection of mechanical stimulus|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|cellular amide metabolic process|substrate-dependent cell migration|detection of mechanical stimulus involved in sensory perception|cellular protein metabolic process|response to amine|regulation of phosphorus metabolic process|gene expression|positive chemotaxis|cell part morphogenesis|nervous system development|viral life cycle|cellular response to organic substance|neuron projection guidance|extracellular matrix organization|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cellular response to mechanical stimulus|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|positive regulation of collagen metabolic process|response to nutrient levels|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|response to alcohol|mesoderm morphogenesis|focal adhesion|hypotonic response|regulation of protein binding|neuron development|neuron differentiation|axon guidance|dephosphorylation|peptide biosynthetic process|positive regulation of protein modification process|smooth muscle contraction|sensory perception of pain|regulation of phagocytosis|integrin alpha2-beta1 complex|sensory perception of mechanical stimulus|epithelial cell differentiation|regulation of muscle contraction|adherens junction organization|collagen-activated signaling pathway|positive regulation of phosphatase activity|detection of mechanical stimulus involved in sensory perception of pain|viral entry into host cell|mesodermal cell differentiation|smooth muscle cell migration|positive regulation of translation|response to monosaccharide|integrin-mediated signaling pathway|response to estrogen|posttranscriptional regulation of gene expression|regulation of smooth muscle cell migration|positive regulation of collagen biosynthetic process|positive regulation of DNA binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|positive regulation of phagocytosis, engulfment|axon development|translation|hepatocyte differentiation|positive regulation of smooth muscle cell migration|cell-substrate junction assembly|positive regulation of protein binding|regulation of translation|response to estradiol|epithelial cell migration|focal adhesion assembly|phagocytosis, engulfment|endocytosis|collagen binding involved in cell-matrix adhesion|neurogenesis|entry into host cell|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|cellular response to lipid|collagen metabolic process|adherens junction assembly|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|positive regulation of alkaline phosphatase activity|positive regulation of collagen binding|regulation of smooth muscle contraction|axonogenesis|generation of neurons|positive regulation of protein dephosphorylation|cellular response to estradiol stimulus|cellular response to estrogen stimulus|positive regulation of dephosphorylation|regulation of dephosphorylation K06481 integrin alpha 2[-] hsa05200|hsa04151|hsa04810|hsa05205|hsa04510|hsa04145|hsa04611|hsa05414|hsa04640|hsa05222|hsa05410|hsa04512|hsa05412 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 5:52989326-53094779 361 376 840 4017 4961 4731 2.82134303291275 2.67065367705733 5.91892188286497 28.128640497221 31.8116617479399 34.6522162997137 3.80363953094502 31.5308395149582 -3.05131114829186 2.62665476991174e-27 4.61271479417325e-25 DOWN ENSG00000116127 ALMS1 ALMS1, centrosome and basal body associated protein [Source:HGNC Symbol;Acc:HGNC:428] GO:0032502|GO:0040007|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0044702|GO:0071704|GO:0019953|GO:0051641|GO:0003006|GO:0045926|GO:0009653|GO:0016043|GO:0040008|GO:0032504|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0048609|GO:0045595|GO:0009888|GO:0007164|GO:0048468|GO:0006810|GO:0048839|GO:0010941|GO:0007275|GO:0048513|GO:0050877|GO:0051128|GO:0022607|GO:0005737|GO:0032970|GO:0007423|GO:0009887|GO:0035264|GO:0042592|GO:0048515|GO:0030728|GO:0048729|GO:0050673|GO:0040015|GO:0036064|GO:0060548|GO:0032231|GO:0007154|GO:0007276|GO:0006629|GO:0007165|GO:0048638|GO:0051649|GO:0008092|GO:0040014|GO:0008219|GO:0048640|GO:0030030|GO:0048869|GO:0030029|GO:0007281|GO:0006996|GO:0051017|GO:0000902|GO:0005813|GO:0007286|GO:0048232|GO:0060113|GO:0001654|GO:0032956|GO:0002009|GO:0007010|GO:0043583|GO:0043069|GO:0048878|GO:0005815|GO:0001736|GO:0005814|GO:0044782|GO:0046907|GO:0042805|GO:0007600|GO:0030031|GO:0060122|GO:0030036|GO:0070925|GO:0012501|GO:0060429|GO:0042384|GO:0035556|GO:0033043|GO:0032990|GO:0007399|GO:0045598|GO:0030154|GO:0048858|GO:0007292|GO:0005856|GO:0051492|GO:0043067|GO:0048666|GO:0030182|GO:0060271|GO:0042461|GO:0007283|GO:0045444|GO:0051393|GO:0050954|GO:0051493|GO:0015630|GO:0016197|GO:0042981|GO:0043066|GO:0060119|GO:0055088|GO:0031032|GO:0022008|GO:0030038|GO:0019932|GO:0007015|GO:0006915|GO:0048592|GO:0033500|GO:0001738|GO:0042593|GO:0007605|GO:0048699|GO:0001754|GO:0042462|GO:0043149|GO:0019722|GO:0042490|GO:0061572|GO:0055092|GO:0042632|GO:0046548 developmental process|growth|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular localization|developmental process involved in reproduction|negative regulation of growth|anatomical structure morphogenesis|cellular component organization|regulation of growth|multicellular organism reproduction|regulation of developmental process|developmental growth|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of cell differentiation|tissue development|establishment of tissue polarity|cell development|transport|inner ear development|regulation of cell death|multicellular organism development|animal organ development|neurological system process|regulation of cellular component organization|cellular component assembly|cytoplasm|regulation of actin filament-based process|sensory organ development|organ morphogenesis|multicellular organism growth|homeostatic process|spermatid differentiation|ovulation|tissue morphogenesis|epithelial cell proliferation|negative regulation of multicellular organism growth|ciliary basal body|negative regulation of cell death|regulation of actin filament bundle assembly|cell communication|gamete generation|lipid metabolic process|signal transduction|regulation of developmental growth|establishment of localization in cell|cytoskeletal protein binding|regulation of multicellular organism growth|cell death|negative regulation of developmental growth|cell projection organization|cellular developmental process|actin filament-based process|germ cell development|organelle organization|actin filament bundle assembly|cell morphogenesis|centrosome|spermatid development|male gamete generation|inner ear receptor cell differentiation|eye development|regulation of actin cytoskeleton organization|morphogenesis of an epithelium|cytoskeleton organization|ear development|negative regulation of programmed cell death|chemical homeostasis|microtubule organizing center|establishment of planar polarity|centriole|cilium organization|intracellular transport|actinin binding|sensory perception|cell projection assembly|inner ear receptor stereocilium organization|actin cytoskeleton organization|organelle assembly|programmed cell death|epithelium development|cilium assembly|intracellular signal transduction|regulation of organelle organization|cell part morphogenesis|nervous system development|regulation of fat cell differentiation|cell differentiation|cell projection morphogenesis|female gamete generation|cytoskeleton|regulation of stress fiber assembly|regulation of programmed cell death|neuron development|neuron differentiation|cilium morphogenesis|photoreceptor cell development|spermatogenesis|fat cell differentiation|alpha-actinin binding|sensory perception of mechanical stimulus|regulation of cytoskeleton organization|microtubule cytoskeleton|endosomal transport|regulation of apoptotic process|negative regulation of apoptotic process|inner ear receptor cell development|lipid homeostasis|actomyosin structure organization|neurogenesis|contractile actin filament bundle assembly|second-messenger-mediated signaling|actin filament organization|apoptotic process|eye morphogenesis|carbohydrate homeostasis|morphogenesis of a polarized epithelium|glucose homeostasis|sensory perception of sound|generation of neurons|eye photoreceptor cell differentiation|eye photoreceptor cell development|stress fiber assembly|calcium-mediated signaling|mechanoreceptor differentiation|actin filament bundle organization|sterol homeostasis|cholesterol homeostasis|retinal rod cell development - - - - 2:73385758-73610793 128 154 168 936 1125 746 0.418579521199136 0.457687786980569 0.49532826693324 2.74247563105838 3.0184893060036 2.28631924209759 0.457198525037648 2.68242805971986 -2.55264682531977 3.24963503991568e-27 5.64038398149086e-25 DOWN ENSG00000118762 PKD2 polycystic kidney disease 2 (autosomal dominant) [Source:HGNC Symbol;Acc:HGNC:9009] GO:0032502|GO:0032991|GO:0004871|GO:0000003|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0004872|GO:0022857|GO:0045178|GO:0048523|GO:0051606|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0005057|GO:0044702|GO:0042175|GO:0071704|GO:0043167|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0038023|GO:0003006|GO:0023051|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:1903828|GO:0009605|GO:0023057|GO:0009893|GO:0031252|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0005929|GO:0031090|GO:0019222|GO:0042802|GO:0048514|GO:0007507|GO:0051219|GO:0060341|GO:1903409|GO:0051726|GO:0042127|GO:0007049|GO:0051282|GO:1900181|GO:0060674|GO:0001890|GO:0098554|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0016323|GO:0044325|GO:0009925|GO:0006810|GO:0022402|GO:0035295|GO:0009612|GO:1901360|GO:0001568|GO:0005884|GO:0034405|GO:0005938|GO:0007275|GO:0010524|GO:0048513|GO:0072028|GO:0005102|GO:0034641|GO:0060170|GO:0044281|GO:2001057|GO:0043270|GO:0031982|GO:0019637|GO:0031325|GO:0051599|GO:0046483|GO:0033554|GO:0015278|GO:0009582|GO:0005887|GO:0045786|GO:0043231|GO:0048608|GO:0031227|GO:0043169|GO:0019899|GO:0004888|GO:0051651|GO:0005737|GO:0007389|GO:0001763|GO:0032880|GO:0009887|GO:0042592|GO:0072593|GO:0072050|GO:0098562|GO:0021915|GO:0009966|GO:0048729|GO:0030027|GO:0046983|GO:0048598|GO:0072006|GO:0048568|GO:0045184|GO:0072372|GO:0019725|GO:0045787|GO:0022891|GO:0006979|GO:0036064|GO:0019904|GO:0032387|GO:0032388|GO:0010646|GO:0006139|GO:0031226|GO:0001892|GO:0043085|GO:0055086|GO:0030176|GO:0008104|GO:0007154|GO:0044092|GO:0055085|GO:0007165|GO:0010523|GO:0005783|GO:0009968|GO:0070062|GO:0051649|GO:0008092|GO:2000021|GO:0031941|GO:0008285|GO:0006970|GO:0090317|GO:0050790|GO:0071804|GO:0031253|GO:0032410|GO:0051238|GO:0016021|GO:0010035|GO:0009967|GO:0044249|GO:0010469|GO:0007017|GO:0019538|GO:0031301|GO:0051224|GO:0031323|GO:0048732|GO:0032411|GO:0034763|GO:0002133|GO:0043271|GO:0006996|GO:0035502|GO:0051284|GO:0045180|GO:0031023|GO:1902533|GO:0032268|GO:0005829|GO:0072218|GO:0003143|GO:0071498|GO:0061441|GO:0010468|GO:0034645|GO:0042308|GO:0090068|GO:0072170|GO:0046872|GO:0002009|GO:1903047|GO:0001944|GO:0043412|GO:0072594|GO:0007010|GO:0072164|GO:0061458|GO:0072358|GO:0007417|GO:0001655|GO:0019693|GO:0072273|GO:0003127|GO:0072210|GO:0071556|GO:0048878|GO:0051252|GO:0051280|GO:0035050|GO:0005815|GO:0021510|GO:0032386|GO:0072284|GO:0051117|GO:0003007|GO:0044770|GO:0048754|GO:0051223|GO:0007098|GO:0071464|GO:0015031|GO:0061138|GO:0007050|GO:0031512|GO:0009790|GO:0001889|GO:0051208|GO:0001656|GO:0010628|GO:0034767|GO:0051926|GO:0072214|GO:0051347|GO:0036211|GO:2000377|GO:0000278|GO:0060840|GO:0070201|GO:0060537|GO:0015267|GO:0048844|GO:0046907|GO:0072001|GO:0006811|GO:0051209|GO:0055082|GO:0046209|GO:0045737|GO:1903428|GO:0072176|GO:0042805|GO:0015075|GO:0032413|GO:0051279|GO:0048763|GO:0060485|GO:0071458|GO:0031585|GO:0007346|GO:2000272|GO:0034599|GO:0071470|GO:0010564|GO:0034766|GO:0032507|GO:0051247|GO:0045930|GO:0034765|GO:0061371|GO:0045428|GO:0061326|GO:0043269|GO:0034613|GO:0032270|GO:0060993|GO:0050982|GO:0060429|GO:0000302|GO:0006796|GO:0035556|GO:0072073|GO:0044267|GO:0051174|GO:0051281|GO:0010467|GO:0017038|GO:0051298|GO:0048562|GO:0007399|GO:0060562|GO:0032414|GO:1902532|GO:0031328|GO:0006809|GO:0051246|GO:0071805|GO:0009059|GO:0010522|GO:0001823|GO:1903827|GO:1902531|GO:0016070|GO:0051928|GO:0072359|GO:0000226|GO:0005856|GO:0010557|GO:0060314|GO:0042803|GO:0005819|GO:1903426|GO:0022898|GO:0006606|GO:0031513|GO:0043398|GO:0072219|GO:0010948|GO:2000273|GO:0034220|GO:2000379|GO:0050850|GO:0060315|GO:0072234|GO:0051220|GO:0015629|GO:0015276|GO:1904589|GO:0045893|GO:0098655|GO:0072208|GO:0033365|GO:1904031|GO:0005216|GO:0033157|GO:0009792|GO:0031401|GO:0090281|GO:0072686|GO:0071156|GO:0051393|GO:0051169|GO:0001657|GO:0009259|GO:2001258|GO:0031659|GO:0009117|GO:0032774|GO:0044772|GO:0090280|GO:0006812|GO:1901021|GO:2001141|GO:0072078|GO:0072163|GO:0016310|GO:0001658|GO:0006605|GO:1903170|GO:0071910|GO:0060402|GO:0005509|GO:0072177|GO:0016482|GO:1901990|GO:0001947|GO:0006886|GO:0032412|GO:0061333|GO:0015630|GO:0031587|GO:0009855|GO:0072075|GO:2001259|GO:1901020|GO:0051297|GO:0006163|GO:0072080|GO:0042992|GO:0035904|GO:0045429|GO:0050801|GO:0048745|GO:0050849|GO:1901987|GO:0042306|GO:1900180|GO:1904427|GO:0034614|GO:0072207|GO:0006464|GO:0003338|GO:0019932|GO:0050848|GO:0042991|GO:0000079|GO:0043549|GO:0006351|GO:0006355|GO:0006873|GO:0090279|GO:0008324|GO:1901991|GO:0071158|GO:0033674|GO:0072070|GO:1903533|GO:1903169|GO:0045944|GO:2000045|GO:0006366|GO:0007259|GO:0006913|GO:0072017|GO:0045859|GO:0045860|GO:0005244|GO:0006357|GO:0006468|GO:0007368|GO:1903506|GO:0072236|GO:0042325|GO:0001932|GO:1902806|GO:0060675|GO:2000134|GO:0000082|GO:0022890|GO:1901019|GO:0009187|GO:0043009|GO:0030001|GO:0001934|GO:0019722|GO:0042990|GO:0051924|GO:0005261|GO:0051371|GO:0042994|GO:2001257|GO:0072235|GO:0030003|GO:0015672|GO:0042327|GO:1902807|GO:0034504|GO:0046822|GO:0005272|GO:0005262|GO:0006813|GO:0051170|GO:0035725|GO:0070588|GO:0046058|GO:0022843|GO:0006814|GO:0055065|GO:0071902|GO:0097553|GO:0006875|GO:0030814|GO:0071900|GO:0001701|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005248|GO:0006874|GO:0006816|GO:0055074|GO:0015085|GO:0005245|GO:0015081|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|macromolecular complex|signal transducer activity|reproduction|transporter activity|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|receptor activity|transmembrane transporter activity|basal part of cell|negative regulation of cellular process|detection of stimulus|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|receptor signaling protein activity|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|signaling receptor activity|developmental process involved in reproduction|regulation of signaling|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of cellular protein localization|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|cilium|organelle membrane|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|heart development|phosphoprotein binding|regulation of cellular localization|reactive oxygen species biosynthetic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of sequestering of calcium ion|negative regulation of protein localization to nucleus|placenta blood vessel development|placenta development|cytoplasmic side of endoplasmic reticulum membrane|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|basolateral plasma membrane|ion channel binding|basal plasma membrane|transport|cell cycle process|tube development|response to mechanical stimulus|organic cyclic compound metabolic process|blood vessel development|actin filament|response to fluid shear stress|cell cortex|multicellular organism development|positive regulation of calcium ion transport into cytosol|animal organ development|nephron morphogenesis|receptor binding|cellular nitrogen compound metabolic process|ciliary membrane|small molecule metabolic process|reactive nitrogen species metabolic process|positive regulation of ion transport|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|response to hydrostatic pressure|heterocycle metabolic process|cellular response to stress|calcium-release channel activity|detection of abiotic stimulus|integral component of plasma membrane|negative regulation of cell cycle|intracellular membrane-bounded organelle|reproductive structure development|intrinsic component of endoplasmic reticulum membrane|cation binding|enzyme binding|transmembrane signaling receptor activity|maintenance of location in cell|cytoplasm|pattern specification process|morphogenesis of a branching structure|regulation of protein localization|organ morphogenesis|homeostatic process|reactive oxygen species metabolic process|S-shaped body morphogenesis|cytoplasmic side of membrane|neural tube development|regulation of signal transduction|tissue morphogenesis|lamellipodium|protein dimerization activity|embryonic morphogenesis|nephron development|embryonic organ development|establishment of protein localization|primary cilium|cellular homeostasis|positive regulation of cell cycle|substrate-specific transmembrane transporter activity|response to oxidative stress|ciliary basal body|protein domain specific binding|negative regulation of intracellular transport|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|embryonic placenta development|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|integral component of endoplasmic reticulum membrane|protein localization|cell communication|negative regulation of molecular function|transmembrane transport|signal transduction|negative regulation of calcium ion transport into cytosol|endoplasmic reticulum|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|regulation of ion homeostasis|filamentous actin|negative regulation of cell proliferation|response to osmotic stress|negative regulation of intracellular protein transport|regulation of catalytic activity|cellular potassium ion transport|cell projection membrane|negative regulation of transporter activity|sequestering of metal ion|integral component of membrane|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|regulation of receptor activity|microtubule-based process|protein metabolic process|integral component of organelle membrane|negative regulation of protein transport|regulation of cellular metabolic process|gland development|positive regulation of transporter activity|negative regulation of transmembrane transport|polycystin complex|negative regulation of ion transport|organelle organization|metanephric part of ureteric bud development|positive regulation of sequestering of calcium ion|basal cortex|microtubule organizing center organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|metanephric ascending thin limb development|embryonic heart tube morphogenesis|cellular response to fluid shear stress|renal artery morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of protein import into nucleus|positive regulation of cell cycle process|metanephric tubule development|metal ion binding|morphogenesis of an epithelium|mitotic cell cycle process|vasculature development|macromolecule modification|establishment of protein localization to organelle|cytoskeleton organization|mesonephric tubule development|reproductive system development|cardiovascular system development|central nervous system development|urogenital system development|ribose phosphate metabolic process|metanephric nephron morphogenesis|detection of nodal flow|metanephric nephron development|integral component of lumenal side of endoplasmic reticulum membrane|chemical homeostasis|regulation of RNA metabolic process|negative regulation of release of sequestered calcium ion into cytosol|embryonic heart tube development|microtubule organizing center|spinal cord development|regulation of intracellular transport|metanephric S-shaped body morphogenesis|ATPase binding|heart morphogenesis|cell cycle phase transition|branching morphogenesis of an epithelial tube|regulation of protein transport|centrosome cycle|cellular response to hydrostatic pressure|protein transport|morphogenesis of a branching epithelium|cell cycle arrest|motile primary cilium|embryo development|liver development|sequestering of calcium ion|metanephros development|positive regulation of gene expression|positive regulation of ion transmembrane transport|negative regulation of calcium ion transport|metanephric cortex development|positive regulation of transferase activity|protein modification process|regulation of reactive oxygen species metabolic process|mitotic cell cycle|artery development|regulation of establishment of protein localization|muscle tissue development|channel activity|artery morphogenesis|intracellular transport|renal system development|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|nitric oxide metabolic process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of reactive oxygen species biosynthetic process|nephric duct development|actinin binding|ion transmembrane transporter activity|negative regulation of ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol|calcium-induced calcium release activity|mesenchyme development|integral component of cytoplasmic side of endoplasmic reticulum membrane|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|regulation of mitotic cell cycle|negative regulation of receptor activity|cellular response to oxidative stress|cellular response to osmotic stress|regulation of cell cycle process|negative regulation of ion transmembrane transport|maintenance of protein location in cell|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|regulation of ion transmembrane transport|determination of heart left/right asymmetry|regulation of nitric oxide biosynthetic process|renal tubule development|regulation of ion transport|cellular protein localization|positive regulation of cellular protein metabolic process|kidney morphogenesis|detection of mechanical stimulus|epithelium development|response to reactive oxygen species|phosphate-containing compound metabolic process|intracellular signal transduction|kidney epithelium development|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of release of sequestered calcium ion into cytosol|gene expression|protein import|centrosome duplication|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|positive regulation of ion transmembrane transporter activity|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|potassium ion transmembrane transport|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|mesonephros development|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of calcium ion transport|circulatory system development|microtubule cytoskeleton organization|cytoskeleton|positive regulation of macromolecule biosynthetic process|regulation of ryanodine-sensitive calcium-release channel activity|protein homodimerization activity|spindle|regulation of reactive oxygen species biosynthetic process|regulation of transmembrane transporter activity|protein import into nucleus|nonmotile primary cilium|HLH domain binding|metanephric cortical collecting duct development|negative regulation of cell cycle process|positive regulation of receptor activity|ion transmembrane transport|positive regulation of reactive oxygen species metabolic process|positive regulation of calcium-mediated signaling|negative regulation of ryanodine-sensitive calcium-release channel activity|metanephric nephron tubule development|cytoplasmic sequestering of protein|actin cytoskeleton|ligand-gated ion channel activity|regulation of protein import|positive regulation of transcription, DNA-templated|cation transmembrane transport|metanephric smooth muscle tissue development|protein localization to organelle|positive regulation of cyclin-dependent protein kinase activity|ion channel activity|regulation of intracellular protein transport|embryo development ending in birth or egg hatching|positive regulation of protein modification process|negative regulation of calcium ion import|mitotic spindle|regulation of cell cycle arrest|alpha-actinin binding|nuclear transport|ureteric bud development|ribonucleotide metabolic process|negative regulation of cation channel activity|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|nucleotide metabolic process|RNA biosynthetic process|mitotic cell cycle phase transition|positive regulation of calcium ion import|cation transport|positive regulation of calcium ion transmembrane transporter activity|regulation of RNA biosynthetic process|nephron tubule morphogenesis|mesonephric epithelium development|phosphorylation|branching involved in ureteric bud morphogenesis|protein targeting|negative regulation of calcium ion transmembrane transport|determination of liver left/right asymmetry|calcium ion transport into cytosol|calcium ion binding|mesonephric duct development|cytosolic transport|regulation of mitotic cell cycle phase transition|heart looping|intracellular protein transport|regulation of ion transmembrane transporter activity|renal tubule morphogenesis|microtubule cytoskeleton|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|determination of bilateral symmetry|metanephric mesenchyme development|positive regulation of cation channel activity|negative regulation of calcium ion transmembrane transporter activity|centrosome organization|purine nucleotide metabolic process|nephron tubule development|negative regulation of transcription factor import into nucleus|aorta development|positive regulation of nitric oxide biosynthetic process|ion homeostasis|smooth muscle tissue development|negative regulation of calcium-mediated signaling|regulation of cell cycle phase transition|regulation of protein import into nucleus|regulation of protein localization to nucleus|positive regulation of calcium ion transmembrane transport|cellular response to reactive oxygen species|metanephric epithelium development|cellular protein modification process|metanephros morphogenesis|second-messenger-mediated signaling|regulation of calcium-mediated signaling|transcription factor import into nucleus|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of calcium ion import|cation transmembrane transporter activity|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|positive regulation of kinase activity|loop of Henle development|regulation of protein targeting|regulation of calcium ion transmembrane transport|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|JAK-STAT cascade|nucleocytoplasmic transport|distal tubule development|regulation of protein kinase activity|positive regulation of protein kinase activity|voltage-gated ion channel activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|determination of left/right symmetry|regulation of nucleic acid-templated transcription|metanephric loop of Henle development|regulation of phosphorylation|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|ureteric bud morphogenesis|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|inorganic cation transmembrane transporter activity|regulation of calcium ion transmembrane transporter activity|cyclic nucleotide metabolic process|chordate embryonic development|metal ion transport|positive regulation of protein phosphorylation|calcium-mediated signaling|regulation of transcription factor import into nucleus|regulation of calcium ion transport|cation channel activity|muscle alpha-actinin binding|cytoplasmic sequestering of transcription factor|regulation of cation channel activity|metanephric distal tubule development|cellular cation homeostasis|monovalent inorganic cation transport|positive regulation of phosphorylation|negative regulation of cell cycle G1/S phase transition|protein localization to nucleus|regulation of nucleocytoplasmic transport|sodium channel activity|calcium channel activity|potassium ion transport|nuclear import|sodium ion transmembrane transport|calcium ion transmembrane transport|cAMP metabolic process|voltage-gated cation channel activity|sodium ion transport|metal ion homeostasis|positive regulation of protein serine/threonine kinase activity|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|regulation of cAMP metabolic process|regulation of protein serine/threonine kinase activity|in utero embryonic development|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated sodium channel activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|calcium ion transmembrane transporter activity|voltage-gated calcium channel activity|sodium ion transmembrane transporter activity|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration - - - - 4:88007668-88077777 54 64 78 418 620 514 0.450874785416384 0.485645341484944 0.587175939451862 3.12704187142213 4.24736575804218 4.02209332458942 0.507898688784397 3.79883365135124 -2.90294388409345 3.23811786323608e-27 5.64038398149086e-25 DOWN ENSG00000164941 INTS8 integrator complex subunit 8 [Source:HGNC Symbol;Acc:HGNC:26048] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0032039|GO:0031981|GO:1990234|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0034660|GO:0016591|GO:0016073|GO:0016180 macromolecular complex|cell|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|integrator complex|nuclear lumen|transferase complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|ncRNA metabolic process|DNA-directed RNA polymerase II, holoenzyme|snRNA metabolic process|snRNA processing - - - - 8:94813311-94881746 267 352 499 2186 2198 2039 1.62746711158726 1.94994660334618 2.7423019036569 11.9384630046585 10.9924924766582 11.6478784456712 2.10657187286345 11.5262779756626 -2.45195767398444 3.45031983541295e-27 5.95409528129585e-25 DOWN ENSG00000140479 PCSK6 proprotein convertase subtilisin/kexin type 6 [Source:HGNC Symbol;Acc:HGNC:8569] GO:0032502|GO:0031012|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0009986|GO:0044237|GO:0042445|GO:0023051|GO:0043227|GO:0016787|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0008201|GO:0006725|GO:0019838|GO:0006810|GO:1901360|GO:0007275|GO:0034641|GO:0043168|GO:0032940|GO:0046483|GO:0090287|GO:0043231|GO:0008233|GO:0005737|GO:0007389|GO:0016486|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0005783|GO:0010817|GO:0044249|GO:0019538|GO:0005539|GO:0010033|GO:0031323|GO:0005794|GO:0017171|GO:0043121|GO:0010468|GO:0071773|GO:0034645|GO:0006518|GO:0007166|GO:0009798|GO:0051252|GO:0009880|GO:0051604|GO:0009790|GO:0009100|GO:0005796|GO:0003002|GO:0070848|GO:0006508|GO:0008236|GO:0043603|GO:0010467|GO:0046903|GO:0071310|GO:0030510|GO:0009059|GO:0032902|GO:0032455|GO:0016070|GO:0004252|GO:0000578|GO:0048406|GO:0016485|GO:0032774|GO:2001141|GO:0071363|GO:0038179|GO:0030509|GO:0007167|GO:0004175|GO:0009948|GO:0009855|GO:0009952|GO:0006351|GO:0035282|GO:0006355|GO:0048011|GO:0008595|GO:0006366|GO:0006357|GO:0007368|GO:1903506|GO:0007178|GO:0007169|GO:0007354 developmental process|extracellular matrix|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cell surface|cellular metabolic process|hormone metabolic process|regulation of signaling|membrane-bounded organelle|hydrolase activity|biosynthetic process|extracellular space|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|heparin binding|cellular aromatic compound metabolic process|growth factor binding|transport|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|anion binding|secretion by cell|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|pattern specification process|peptide hormone processing|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|endoplasmic reticulum|regulation of hormone levels|cellular biosynthetic process|protein metabolic process|glycosaminoglycan binding|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|serine hydrolase activity|neurotrophin binding|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|peptide metabolic process|cell surface receptor signaling pathway|axis specification|regulation of RNA metabolic process|embryonic pattern specification|protein maturation|embryo development|glycoprotein metabolic process|Golgi lumen|regionalization|response to growth factor|proteolysis|serine-type peptidase activity|cellular amide metabolic process|gene expression|secretion|cellular response to organic substance|regulation of BMP signaling pathway|macromolecule biosynthetic process|nerve growth factor production|nerve growth factor processing|RNA metabolic process|serine-type endopeptidase activity|embryonic axis specification|nerve growth factor binding|protein processing|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|neurotrophin signaling pathway|BMP signaling pathway|enzyme linked receptor protein signaling pathway|endopeptidase activity|anterior/posterior axis specification|determination of bilateral symmetry|anterior/posterior pattern specification|transcription, DNA-templated|segmentation|regulation of transcription, DNA-templated|neurotrophin TRK receptor signaling pathway|anterior/posterior axis specification, embryo|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|determination of left/right symmetry|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|zygotic determination of anterior/posterior axis, embryo - - - - 15:101297142-101525202 46 40 57 357 452 385 0.141923340058158 0.112159989669943 0.158557545308242 0.986881276276943 1.14420749357026 1.11323702290703 0.137546958345448 1.08144193091808 -2.97496005847976 4.08116756171127e-27 7.00225151651311e-25 DOWN ENSG00000151090 THRB thyroid hormone receptor, beta [Source:HGNC Symbol;Acc:HGNC:11799] GO:0032502|GO:0032991|GO:0004871|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:1903561|GO:0051716|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0042562|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0038023|GO:0000989|GO:0009653|GO:0000785|GO:0043227|GO:0004879|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0098531|GO:0007618|GO:0004887|GO:0003712|GO:0006725|GO:0003707|GO:0009888|GO:0035295|GO:1901360|GO:0045924|GO:0007275|GO:0030324|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0070324|GO:0043231|GO:0043169|GO:0019899|GO:0000981|GO:0009887|GO:0009890|GO:0003682|GO:0030323|GO:0006139|GO:0000790|GO:0007154|GO:0007165|GO:0070062|GO:0009725|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0003013|GO:0060479|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0046872|GO:0033993|GO:0010629|GO:0051252|GO:0060541|GO:0010628|GO:0007600|GO:0031981|GO:0007621|GO:0005654|GO:0005694|GO:0000228|GO:0007617|GO:0014070|GO:0060429|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0009755|GO:0016070|GO:0008015|GO:0032870|GO:0060428|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0031490|GO:0008016|GO:0043401|GO:0045893|GO:0043566|GO:0050954|GO:0030855|GO:0045892|GO:0060487|GO:0032774|GO:0043565|GO:0060047|GO:0060180|GO:2001141|GO:1902679|GO:0071383|GO:0071407|GO:0046914|GO:0071396|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006352|GO:0007605|GO:0006357|GO:0060509|GO:1903506|GO:0008050|GO:0000122|GO:0008270|GO:0006367 developmental process|macromolecular complex|signal transducer activity|reproduction|behavior|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|hormone binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|signaling receptor activity|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|membrane-bounded organelle|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|mating|thyroid hormone receptor activity|transcription cofactor activity|cellular aromatic compound metabolic process|steroid hormone receptor activity|tissue development|tube development|organic cyclic compound metabolic process|regulation of female receptivity|multicellular organism development|lung development|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|thyroid hormone binding|intracellular membrane-bounded organelle|cation binding|enzyme binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|organ morphogenesis|negative regulation of biosynthetic process|chromatin binding|respiratory tube development|nucleobase-containing compound metabolic process|nuclear chromatin|cell communication|signal transduction|extracellular exosome|response to hormone|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|lung cell differentiation|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|metal ion binding|response to lipid|negative regulation of gene expression|regulation of RNA metabolic process|respiratory system development|positive regulation of gene expression|sensory perception|nuclear lumen|negative regulation of female receptivity|nucleoplasm|chromosome|nuclear chromosome|mating behavior|response to organic cyclic compound|epithelium development|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|RNA metabolic process|blood circulation|cellular response to hormone stimulus|lung epithelium development|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|chromatin DNA binding|regulation of heart contraction|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|structure-specific DNA binding|sensory perception of mechanical stimulus|epithelial cell differentiation|negative regulation of transcription, DNA-templated|lung epithelial cell differentiation|RNA biosynthetic process|sequence-specific DNA binding|heart contraction|female mating behavior|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|transition metal ion binding|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|sensory perception of sound|regulation of transcription from RNA polymerase II promoter|Type I pneumocyte differentiation|regulation of nucleic acid-templated transcription|female courtship behavior|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|transcription initiation from RNA polymerase II promoter K08362 thyroid hormone receptor beta[-] hsa04080|hsa04919 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human) 3:24117160-24495282 35 43 58 364 414 353 0.149286908743917 0.166689846482022 0.22304994376843 1.39109146950936 1.44885265909689 1.41110888940252 0.179675566331456 1.41701767266959 -2.97939161277287 5.20348221352691e-27 8.87684331443613e-25 DOWN ENSG00000274600 RIMBP3B RIMS binding protein 3B [Source:HGNC Symbol;Acc:HGNC:33891] GO:0005488|GO:0005515 binding|protein binding - - - - 22:21383374-21389478 0 0 0 66 69 51 0 0 0 0.685177401413104 0.655957258452469 0.553807717406394 0 0.631647459090656 -Inf 5.24124719535097e-27 8.89046555511408e-25 DOWN ENSG00000040341 STAU2 staufen double-stranded RNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:11371] GO:0005623|GO:0016020|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0003676|GO:0005874|GO:0043231|GO:0005737|GO:0005783|GO:0005730|GO:0003723|GO:0031981|GO:0005856|GO:0005634|GO:0003725|GO:0015630|GO:0044822 cell|membrane|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|transport|nucleic acid binding|microtubule|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|nucleolus|RNA binding|nuclear lumen|cytoskeleton|nucleus|double-stranded RNA binding|microtubule cytoskeleton|poly(A) RNA binding - - - - 8:73420369-73747708 64 42 99 652 625 680 0.191990958928298 0.114506644924551 0.267763370516976 1.75245569546188 1.53833259530777 1.91178745533844 0.191420324789942 1.73419191536936 -3.17944763732093 5.48997845400822e-27 9.25976365909386e-25 DOWN ENSG00000127527 EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 [Source:HGNC Symbol;Acc:HGNC:24634] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0043167|GO:0023051|GO:0043227|GO:0071944|GO:0023057|GO:0005905|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0006810|GO:0098797|GO:0030117|GO:0043231|GO:0043169|GO:0005737|GO:0009966|GO:0010646|GO:0030132|GO:0007154|GO:0007165|GO:0009968|GO:0016192|GO:0046872|GO:0007166|GO:1901184|GO:1901185|GO:0030118|GO:0005634|GO:0042058|GO:0005509|GO:0007167|GO:0042059|GO:0006897|GO:0007169|GO:0038127|GO:0007173 macromolecular complex|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|ion binding|regulation of signaling|membrane-bounded organelle|cell periphery|negative regulation of signaling|coated pit|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|transport|plasma membrane protein complex|membrane coat|intracellular membrane-bounded organelle|cation binding|cytoplasm|regulation of signal transduction|regulation of cell communication|clathrin coat of coated pit|cell communication|signal transduction|negative regulation of signal transduction|vesicle-mediated transport|metal ion binding|cell surface receptor signaling pathway|regulation of ERBB signaling pathway|negative regulation of ERBB signaling pathway|clathrin coat|nucleus|regulation of epidermal growth factor receptor signaling pathway|calcium ion binding|enzyme linked receptor protein signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|endocytosis|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K12472 epidermal growth factor receptor substrate 15[-] hsa04144 Endocytosis - Homo sapiens (human) 19:16355239-16472085 105 101 168 869 915 723 0.648963612474991 0.567326162922139 0.936168260553335 4.81224408442954 4.64000832737911 4.18790631995407 0.717486011983488 4.54671957725424 -2.6638034168237 5.84165245691324e-27 9.79756699149931e-25 DOWN ENSG00000275993 CH507-42P11.8 - GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0005622|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043169|GO:0007154|GO:0007165|GO:0000166|GO:0019538|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0016773|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|intracellular|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|cell communication|signal transduction|nucleotide binding|protein metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 21:6111134-6123739 992 911 1196 191 242 251 14.0173674053288 11.6991257427099 15.2370251173506 2.41816341980166 2.80568446966125 3.32397874397109 13.6511727551298 2.849275544478 2.260357844569 7.00240034267487e-27 1.16787519458221e-24 UP ENSG00000196141 SPATS2L spermatogenesis associated, serine rich 2 like [Source:HGNC Symbol;Acc:HGNC:24574] GO:0032991|GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0003676|GO:0043231|GO:0005737|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 macromolecular complex|cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|protein complex|nucleic acid binding|intracellular membrane-bounded organelle|cytoplasm|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 2:200305881-200482263 738 859 1238 5156 5374 4566 2.14609747629414 2.27021104871097 3.24584415921749 13.4339423518342 12.8220808991914 12.4439351253084 2.55405089474087 12.8999861254447 -2.3365103348424 8.20792673667569e-27 1.36133024887064e-24 DOWN ENSG00000152818 UTRN utrophin [Source:HGNC Symbol;Acc:HGNC:12635] GO:0032502|GO:0032991|GO:0045202|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0005488|GO:1903561|GO:0005200|GO:0042995|GO:0031594|GO:0044877|GO:0050794|GO:0070938|GO:0043229|GO:0043167|GO:0016043|GO:0030427|GO:0007155|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0097060|GO:0006810|GO:0005938|GO:0098797|GO:0007275|GO:0048513|GO:0005102|GO:0030155|GO:0031982|GO:0030426|GO:0045211|GO:0061061|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0032403|GO:0016203|GO:0043005|GO:0031589|GO:0050839|GO:0042383|GO:0055085|GO:0070062|GO:0050808|GO:0045785|GO:0008092|GO:0031253|GO:0001948|GO:0006936|GO:0030864|GO:0046872|GO:0007528|GO:0003779|GO:0016010|GO:0007160|GO:0005178|GO:0006811|GO:0031981|GO:0010810|GO:0017166|GO:0034765|GO:0005654|GO:0030175|GO:0043269|GO:0031527|GO:0051015|GO:0019900|GO:0002162|GO:0010811|GO:0007517|GO:0005856|GO:0005634|GO:0022898|GO:0034220|GO:0015629|GO:0060538|GO:0098655|GO:0006812|GO:0032412|GO:0001952|GO:0001954|GO:0046914|GO:0019901|GO:0030863|GO:0002028|GO:1902305|GO:0030001|GO:2000649|GO:0008270|GO:0015672|GO:0035725|GO:0006814 developmental process|macromolecular complex|synapse|structural molecule activity|cell|membrane|cellular process|extracellular region|cell junction|binding|extracellular vesicle|structural constituent of cytoskeleton|cell projection|neuromuscular junction|macromolecular complex binding|regulation of cellular process|contractile ring|intracellular organelle|ion binding|cellular component organization|site of polarized growth|cell adhesion|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|synaptic membrane|transport|cell cortex|plasma membrane protein complex|multicellular organism development|animal organ development|receptor binding|regulation of cell adhesion|vesicle|growth cone|postsynaptic membrane|muscle structure development|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|muscle system process|protein complex binding|muscle attachment|neuron projection|cell-substrate adhesion|cell adhesion molecule binding|sarcolemma|transmembrane transport|extracellular exosome|synapse organization|positive regulation of cell adhesion|cytoskeletal protein binding|cell projection membrane|glycoprotein binding|muscle contraction|cortical actin cytoskeleton|metal ion binding|neuromuscular junction development|actin binding|dystrophin-associated glycoprotein complex|cell-matrix adhesion|integrin binding|ion transport|nuclear lumen|regulation of cell-substrate adhesion|vinculin binding|regulation of ion transmembrane transport|nucleoplasm|filopodium|regulation of ion transport|filopodium membrane|actin filament binding|kinase binding|dystroglycan binding|positive regulation of cell-substrate adhesion|muscle organ development|cytoskeleton|nucleus|regulation of transmembrane transporter activity|ion transmembrane transport|actin cytoskeleton|skeletal muscle organ development|cation transmembrane transport|cation transport|regulation of ion transmembrane transporter activity|regulation of cell-matrix adhesion|positive regulation of cell-matrix adhesion|transition metal ion binding|protein kinase binding|cortical cytoskeleton|regulation of sodium ion transport|regulation of sodium ion transmembrane transport|metal ion transport|regulation of sodium ion transmembrane transporter activity|zinc ion binding|monovalent inorganic cation transport|sodium ion transmembrane transport|sodium ion transport - - - - 6:144285701-144853034 129 180 354 1869 2054 2557 0.580142432225897 0.735692947691049 1.43536332072306 7.53098138050233 7.57901798862643 10.7771598314862 0.917066233546669 8.62905306687165 -3.2341044110513 9.88457855323549e-27 1.63035474104029e-24 DOWN ENSG00000119661 DNAL1 dynein, axonemal, light chain 1 [Source:HGNC Symbol;Acc:HGNC:23247] GO:0005488|GO:0005515 binding|protein binding K10411 dynein light chain 1, axonemal[-] hsa05016 Huntington,s disease - Homo sapiens (human) 14:73644875-73703732 23 58 36 479 437 455 0.138171663628972 0.316659322342763 0.194984554015112 2.57821100351483 2.15394510749576 2.56168340139137 0.216605179995616 2.43127983746732 -3.48857630569412 1.03626265942858e-26 1.69981238651543e-24 DOWN ENSG00000114670 NEK11 NIMA-related kinase 11 [Source:HGNC Symbol;Acc:HGNC:18593] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0051726|GO:0007049|GO:0022402|GO:0016570|GO:0043168|GO:0001882|GO:0016772|GO:0033554|GO:0045786|GO:0043231|GO:0043169|GO:0007154|GO:0007165|GO:0000166|GO:0019538|GO:0006996|GO:0051276|GO:0005730|GO:0000075|GO:0046872|GO:0035639|GO:1903047|GO:0043412|GO:0016572|GO:0006325|GO:0001883|GO:0044770|GO:0036211|GO:0000278|GO:0032549|GO:0031981|GO:0007346|GO:0010564|GO:0045930|GO:0005654|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0016773|GO:0005634|GO:0006974|GO:0007093|GO:0005524|GO:0044772|GO:0030554|GO:0016310|GO:0044774|GO:0000077|GO:1901990|GO:0004672|GO:0016568|GO:1901987|GO:0006464|GO:0044773|GO:0006468|GO:0031573|GO:0004674|GO:0031572 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|transferase activity|regulation of cell cycle|cell cycle|cell cycle process|histone modification|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|cell communication|signal transduction|nucleotide binding|protein metabolic process|organelle organization|chromosome organization|nucleolus|cell cycle checkpoint|metal ion binding|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|histone phosphorylation|chromatin organization|purine nucleoside binding|cell cycle phase transition|protein modification process|mitotic cell cycle|ribonucleoside binding|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|cellular response to DNA damage stimulus|mitotic cell cycle checkpoint|ATP binding|mitotic cell cycle phase transition|adenyl nucleotide binding|phosphorylation|mitotic DNA integrity checkpoint|DNA damage checkpoint|regulation of mitotic cell cycle phase transition|protein kinase activity|chromatin modification|regulation of cell cycle phase transition|cellular protein modification process|mitotic DNA damage checkpoint|protein phosphorylation|intra-S DNA damage checkpoint|protein serine/threonine kinase activity|G2 DNA damage checkpoint - - - - 3:131026850-131350465 19 21 24 217 222 222 0.117234021850103 0.117765506657216 0.133514174770358 1.19968284447774 1.12390586830327 1.28378130751604 0.122837901092559 1.20245667343235 -3.29115724046674 1.28370876324878e-26 2.09419898459175e-24 DOWN ENSG00000091542 ALKBH5 alkB homolog 5, RNA demethylase [Source:HGNC Symbol;Acc:HGNC:25996] GO:0032502|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0097159|GO:0032451|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0019953|GO:0044237|GO:0051641|GO:0006914|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0032504|GO:0005622|GO:0002682|GO:0048609|GO:0006725|GO:0051213|GO:0006810|GO:1901360|GO:0050688|GO:0003676|GO:0071166|GO:0034641|GO:0006952|GO:0046483|GO:0098542|GO:0043231|GO:0043169|GO:0035515|GO:0016705|GO:0009615|GO:0070988|GO:0006139|GO:0007276|GO:0051649|GO:0006403|GO:0016236|GO:0001666|GO:0051607|GO:0048869|GO:0055114|GO:0070989|GO:0048232|GO:0035553|GO:0046872|GO:0098792|GO:0003723|GO:0043412|GO:0046907|GO:0031981|GO:0016706|GO:0005654|GO:0050658|GO:0010467|GO:0030154|GO:0016070|GO:0005634|GO:0050691|GO:0007283|GO:0051028|GO:0051169|GO:0006396|GO:0009451|GO:0016604|GO:0002230|GO:0016071|GO:0044822|GO:0006406|GO:0006405|GO:0016607|GO:0006913|GO:0006397|GO:0051168 developmental process|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|organic cyclic compound binding|demethylase activity|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|sexual reproduction|cellular metabolic process|cellular localization|autophagy|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|multicellular organism reproduction|intracellular|regulation of immune system process|multicellular organismal reproductive process|cellular aromatic compound metabolic process|dioxygenase activity|transport|organic cyclic compound metabolic process|regulation of defense response to virus|nucleic acid binding|ribonucleoprotein complex localization|cellular nitrogen compound metabolic process|defense response|heterocycle metabolic process|defense response to other organism|intracellular membrane-bounded organelle|cation binding|oxidative RNA demethylase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|response to virus|demethylation|nucleobase-containing compound metabolic process|gamete generation|establishment of localization in cell|RNA localization|macroautophagy|response to hypoxia|defense response to virus|cellular developmental process|oxidation-reduction process|oxidative demethylation|male gamete generation|oxidative single-stranded RNA demethylation|metal ion binding|xenophagy|RNA binding|macromolecule modification|intracellular transport|nuclear lumen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|nucleoplasm|RNA transport|gene expression|cell differentiation|RNA metabolic process|nucleus|regulation of defense response to virus by host|spermatogenesis|mRNA transport|nuclear transport|RNA processing|RNA modification|nuclear body|positive regulation of defense response to virus by host|mRNA metabolic process|poly(A) RNA binding|mRNA export from nucleus|RNA export from nucleus|nuclear speck|nucleocytoplasmic transport|mRNA processing|nuclear export - - - - 17:18183078-18209954 222 223 428 1775 2078 1880 3.46963761487639 3.16749862754979 6.03099249286396 24.8557663154032 26.6467764453469 27.537087058926 4.22270957843005 26.3465432732254 -2.64137275668737 1.53680802447087e-26 2.49347101970399e-24 DOWN ENSG00000154978 VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 [Source:HGNC Symbol;Acc:HGNC:34518] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0012506|GO:0006139|GO:0007154|GO:0007165|GO:0016021|GO:0044249|GO:0031301|GO:0031323|GO:0005768|GO:0010468|GO:0034645|GO:0031410|GO:0051252|GO:0016023|GO:0031988|GO:0030659|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|nucleobase-containing compound metabolic process|cell communication|signal transduction|integral component of membrane|cellular biosynthetic process|integral component of organelle membrane|regulation of cellular metabolic process|endosome|regulation of gene expression|cellular macromolecule biosynthetic process|cytoplasmic vesicle|regulation of RNA metabolic process|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|cytoplasmic vesicle membrane|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 7:55436056-55572988 581 669 1071 4432 4445 4273 3.08590542948847 3.22933139477064 5.12873741230711 21.0913387339021 19.3707484597193 21.2700503409815 3.81465807885541 20.577379178201 -2.43143359204175 1.54932947862239e-26 2.5001990407996e-24 DOWN ENSG00000145819 ARHGAP26 Rho GTPase activating protein 26 [Source:HGNC Symbol;Acc:HGNC:17073] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0030055|GO:0050794|GO:0043229|GO:0043167|GO:0023051|GO:0016043|GO:0008289|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0007275|GO:0043168|GO:0008047|GO:0005924|GO:0005912|GO:0005543|GO:0005737|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0061024|GO:0007165|GO:0050790|GO:0030029|GO:0010256|GO:0006996|GO:0005829|GO:0005096|GO:0007010|GO:0051345|GO:0030695|GO:0007009|GO:0030036|GO:0035556|GO:0007399|GO:1902531|GO:0005856|GO:0005925|GO:0043087|GO:0043547|GO:0051056|GO:0007264 developmental process|signaling|cell|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell-substrate junction|regulation of cellular process|intracellular organelle|ion binding|regulation of signaling|cellular component organization|lipid binding|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|anatomical structure development|regulation of metabolic process|multicellular organism development|anion binding|enzyme activator activity|cell-substrate adherens junction|adherens junction|phospholipid binding|cytoplasm|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|membrane organization|signal transduction|regulation of catalytic activity|actin filament-based process|endomembrane system organization|organelle organization|cytosol|GTPase activator activity|cytoskeleton organization|positive regulation of hydrolase activity|GTPase regulator activity|plasma membrane organization|actin cytoskeleton organization|intracellular signal transduction|nervous system development|regulation of intracellular signal transduction|cytoskeleton|focal adhesion|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 5:142770384-143229011 32 50 65 368 536 552 0.101397891786377 0.143986969358246 0.185695809767773 1.04476726127802 1.39349865407675 1.63923647362823 0.143693556970799 1.35916746299433 -3.24165594166317 1.57894975677353e-26 2.53429924939338e-24 DOWN ENSG00000141376 BCAS3 breast carcinoma amplified sequence 3 [Source:HGNC Symbol;Acc:HGNC:14347] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044089|GO:0071704|GO:0044237|GO:0051641|GO:0048870|GO:0040017|GO:0009653|GO:0000785|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0031252|GO:0009058|GO:0030234|GO:0005622|GO:1903829|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0060341|GO:0051272|GO:0035239|GO:0006725|GO:0042393|GO:0006810|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0009991|GO:0007275|GO:0010632|GO:0005102|GO:0034641|GO:0008047|GO:0005874|GO:0030155|GO:0051491|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0032970|GO:0032880|GO:0051222|GO:0006928|GO:1901888|GO:0031589|GO:0045184|GO:0003682|GO:0032388|GO:0006139|GO:0043085|GO:0007162|GO:0001525|GO:0008104|GO:0007163|GO:0044092|GO:0035148|GO:0051270|GO:0060491|GO:0016477|GO:0051649|GO:0008134|GO:0008092|GO:0009725|GO:0090316|GO:0010634|GO:0050790|GO:0030030|GO:0043086|GO:0030029|GO:2000145|GO:0035327|GO:0044249|GO:0032878|GO:0007017|GO:0010033|GO:0031323|GO:0010256|GO:0042594|GO:0006996|GO:0031023|GO:0005730|GO:0015631|GO:0031344|GO:0010468|GO:0090132|GO:0034645|GO:0045216|GO:1903392|GO:2000114|GO:0032956|GO:0033993|GO:0001944|GO:0007010|GO:0007030|GO:0072358|GO:0051345|GO:0051427|GO:0035035|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0031346|GO:0010628|GO:0030334|GO:0010812|GO:0001667|GO:0070201|GO:0007160|GO:0046907|GO:0010698|GO:0034329|GO:0031981|GO:0030010|GO:0030031|GO:0010810|GO:0051346|GO:0005694|GO:0030036|GO:0034613|GO:0014070|GO:0033043|GO:0010467|GO:0071310|GO:0010594|GO:0031328|GO:0009059|GO:0005881|GO:0030335|GO:1903827|GO:0016070|GO:0072359|GO:0000226|GO:0031667|GO:0032870|GO:0005856|GO:0010557|GO:0005634|GO:0048545|GO:0010595|GO:0051489|GO:0010638|GO:0045893|GO:0033157|GO:0031532|GO:0048487|GO:0034332|GO:0032774|GO:2000249|GO:2001141|GO:0035257|GO:0001953|GO:0043087|GO:0043627|GO:0071383|GO:0071407|GO:0006886|GO:0043547|GO:0051493|GO:0001952|GO:0046847|GO:0007044|GO:0015630|GO:0051895|GO:0045111|GO:0010631|GO:0048041|GO:0051893|GO:0051495|GO:0071396|GO:0034260|GO:0006351|GO:0006355|GO:0034333|GO:0045944|GO:0006366|GO:0090630|GO:0006357|GO:1903506|GO:2000251|GO:0071391|GO:0043542 locomotion|developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|cellular metabolic process|cellular localization|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|chromatin|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|cell leading edge|biosynthetic process|enzyme regulator activity|intracellular|positive regulation of cellular protein localization|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cellular component movement|tube morphogenesis|cellular aromatic compound metabolic process|histone binding|transport|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|response to extracellular stimulus|multicellular organism development|regulation of epithelial cell migration|receptor binding|cellular nitrogen compound metabolic process|enzyme activator activity|microtubule|regulation of cell adhesion|positive regulation of filopodium assembly|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of actin filament-based process|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|regulation of cell junction assembly|cell-substrate adhesion|establishment of protein localization|chromatin binding|positive regulation of intracellular transport|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|negative regulation of cell adhesion|angiogenesis|protein localization|establishment or maintenance of cell polarity|negative regulation of molecular function|tube formation|regulation of cellular component movement|regulation of cell projection assembly|cell migration|establishment of localization in cell|transcription factor binding|cytoskeletal protein binding|response to hormone|positive regulation of intracellular protein transport|positive regulation of epithelial cell migration|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|actin filament-based process|regulation of cell motility|transcriptionally active chromatin|cellular biosynthetic process|regulation of establishment or maintenance of cell polarity|microtubule-based process|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|response to starvation|organelle organization|microtubule organizing center organization|nucleolus|tubulin binding|regulation of cell projection organization|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|cell-cell junction organization|negative regulation of adherens junction organization|regulation of establishment of cell polarity|regulation of actin cytoskeleton organization|response to lipid|vasculature development|cytoskeleton organization|Golgi organization|cardiovascular system development|positive regulation of hydrolase activity|hormone receptor binding|histone acetyltransferase binding|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|positive regulation of cell projection organization|positive regulation of gene expression|regulation of cell migration|negative regulation of cell-substrate adhesion|ameboidal-type cell migration|regulation of establishment of protein localization|cell-matrix adhesion|intracellular transport|acetyltransferase activator activity|cell junction assembly|nuclear lumen|establishment of cell polarity|cell projection assembly|regulation of cell-substrate adhesion|negative regulation of hydrolase activity|chromosome|actin cytoskeleton organization|cellular protein localization|response to organic cyclic compound|regulation of organelle organization|gene expression|cellular response to organic substance|regulation of endothelial cell migration|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cytoplasmic microtubule|positive regulation of cell migration|regulation of cellular protein localization|RNA metabolic process|circulatory system development|microtubule cytoskeleton organization|response to nutrient levels|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|positive regulation of endothelial cell migration|regulation of filopodium assembly|positive regulation of organelle organization|positive regulation of transcription, DNA-templated|regulation of intracellular protein transport|actin cytoskeleton reorganization|beta-tubulin binding|adherens junction organization|RNA biosynthetic process|regulation of actin cytoskeleton reorganization|regulation of RNA biosynthetic process|nuclear hormone receptor binding|negative regulation of cell-matrix adhesion|regulation of GTPase activity|response to estrogen|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular protein transport|positive regulation of GTPase activity|regulation of cytoskeleton organization|regulation of cell-matrix adhesion|filopodium assembly|cell-substrate junction assembly|microtubule cytoskeleton|negative regulation of focal adhesion assembly|intermediate filament cytoskeleton|epithelial cell migration|focal adhesion assembly|regulation of focal adhesion assembly|positive regulation of cytoskeleton organization|cellular response to lipid|negative regulation of GTPase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|adherens junction assembly|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|activation of GTPase activity|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|positive regulation of actin cytoskeleton reorganization|cellular response to estrogen stimulus|endothelial cell migration - - - - 17:60677453-61392838 15 19 23 184 234 238 0.0537070548034483 0.0618287691921538 0.074248928009088 0.590286098926165 0.687432931691446 0.798642532339955 0.0632615840015634 0.692120520985855 -3.45162169553437 1.8872019662878e-26 3.01286243323829e-24 DOWN ENSG00000075539 FRYL FRY like transcription coactivator [Source:HGNC Symbol;Acc:HGNC:29127] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0030427|GO:0071944|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:0048468|GO:1901360|GO:0005938|GO:0007275|GO:0034641|GO:0046483|GO:0005737|GO:0006139|GO:0030030|GO:0048869|GO:0030029|GO:0044249|GO:0031323|GO:0006996|GO:0000902|GO:0031175|GO:0010468|GO:0034645|GO:0007010|GO:0051252|GO:0030036|GO:0010467|GO:0007399|GO:0009059|GO:0030154|GO:0016070|GO:0048666|GO:0030182|GO:0031532|GO:0032774|GO:2001141|GO:0022008|GO:0007015|GO:0006351|GO:0006355|GO:0048699|GO:1903506|GO:0090527 developmental process|cell|cellular process|metabolic process|binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell periphery|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|cell cortex|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cytoplasm|nucleobase-containing compound metabolic process|cell projection organization|cellular developmental process|actin filament-based process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|cell morphogenesis|neuron projection development|regulation of gene expression|cellular macromolecule biosynthetic process|cytoskeleton organization|regulation of RNA metabolic process|actin cytoskeleton organization|gene expression|nervous system development|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|neuron development|neuron differentiation|actin cytoskeleton reorganization|RNA biosynthetic process|regulation of RNA biosynthetic process|neurogenesis|actin filament organization|transcription, DNA-templated|regulation of transcription, DNA-templated|generation of neurons|regulation of nucleic acid-templated transcription|actin filament reorganization - - - - 4:48497361-48780322 138 129 310 1494 1729 1604 0.342191450677921 0.29071028824825 0.693050868726164 3.31923398478665 3.51765064985418 3.72754454557737 0.441984202550778 3.52147639340607 -2.99411370081708 2.25694102657614e-26 3.56501150303725e-24 DOWN ENSG00000175893 ZDHHC21 zinc finger, DHHC-type containing 21 [Source:HGNC Symbol;Acc:HGNC:20750] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0009888|GO:0007275|GO:0048513|GO:0044281|GO:2001057|GO:0043231|GO:0043169|GO:0016746|GO:0001942|GO:0005737|GO:0072593|GO:0050790|GO:0016021|GO:0044249|GO:0019538|GO:0048732|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0022405|GO:0048733|GO:0036211|GO:0046209|GO:0042157|GO:0016747|GO:0043588|GO:0051341|GO:0060429|GO:0044267|GO:0000139|GO:0009059|GO:0042633|GO:0016409|GO:0008544|GO:0042158|GO:0046914|GO:0006464|GO:0098773|GO:0019706|GO:0018193|GO:0050999|GO:0006497|GO:0008270|GO:0018345|GO:0018230 developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|tissue development|multicellular organism development|animal organ development|small molecule metabolic process|reactive nitrogen species metabolic process|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|hair follicle development|cytoplasm|reactive oxygen species metabolic process|regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|protein metabolic process|gland development|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|hair cycle process|sebaceous gland development|protein modification process|nitric oxide metabolic process|lipoprotein metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|skin development|regulation of oxidoreductase activity|epithelium development|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|hair cycle|palmitoyltransferase activity|epidermis development|lipoprotein biosynthetic process|transition metal ion binding|cellular protein modification process|skin epidermis development|protein-cysteine S-palmitoyltransferase activity|peptidyl-amino acid modification|regulation of nitric-oxide synthase activity|protein lipidation|zinc ion binding|protein palmitoylation|peptidyl-L-cysteine S-palmitoylation - - - - 9:14611071-14693471 14 29 28 258 303 241 0.104653507579331 0.197015976429344 0.188705347939791 1.7279597282738 1.85834767635512 1.68834820934601 0.163458277316155 1.75821853799164 -3.42712006130379 2.24976028580471e-26 3.56501150303725e-24 DOWN ENSG00000074211 PPP2R2C protein phosphatase 2 regulatory subunit B, gamma [Source:HGNC Symbol;Acc:HGNC:9306] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0071704|GO:0044237|GO:0008287|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0019208|GO:0000159|GO:0050790|GO:0019538|GO:0031323|GO:0032268|GO:0043412|GO:0036211|GO:0006796|GO:0044267|GO:0051174|GO:0019888|GO:0051246|GO:0016311|GO:0008601|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0043666|GO:0035303|GO:0034047 macromolecular complex|cell|cellular process|metabolic process|binding|regulation of cellular process|organic substance metabolic process|cellular metabolic process|protein serine/threonine phosphatase complex|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|phosphatase regulator activity|protein phosphatase type 2A complex|regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|protein phosphatase regulator activity|regulation of protein metabolic process|dephosphorylation|protein phosphatase type 2A regulator activity|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|regulation of dephosphorylation|regulation of protein phosphatase type 2A activity K04354 serine/threonine-protein phosphatase 2A regulatory subunit B[-] hsa04151|hsa04390|hsa04261|hsa04530|hsa05160|hsa04728|hsa04152|hsa04071|hsa05142|hsa03015 PI3K-Akt signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human) 4:6320578-6563600 29 24 84 648 732 679 0.171175961024711 0.128746265845934 0.447031280959317 3.42701784784412 3.54505309124525 3.75614673326959 0.248984502609987 3.57607255745299 -3.84424815525727 2.80461623809854e-26 4.40679016695757e-24 DOWN ENSG00000136715 SAP130 Sin3A associated protein 130kDa [Source:HGNC Symbol;Acc:HGNC:29813] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0000988|GO:0003824|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0016740|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0016570|GO:0034641|GO:0046483|GO:0043231|GO:0016746|GO:0009890|GO:0006139|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0003713|GO:0051276|GO:0010468|GO:0034645|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0016573|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0016747|GO:0044267|GO:0010467|GO:0000123|GO:0009059|GO:0016070|GO:0005634|GO:0045814|GO:0045892|GO:0032774|GO:2001141|GO:0043966|GO:1902679|GO:0040029|GO:0016407|GO:0016410|GO:0016568|GO:0070461|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0018193|GO:0008080|GO:0030914|GO:0000122|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402 macromolecular complex|cell|cellular process|metabolic process|transcription factor activity, protein binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|transferase activity|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|histone acetylation|protein modification process|nuclear lumen|transferase complex|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein metabolic process|gene expression|histone acetyltransferase complex|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|histone H3 acetylation|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|acetyltransferase activity|N-acyltransferase activity|chromatin modification|SAGA-type complex|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|N-acetyltransferase activity|STAGA complex|negative regulation of transcription from RNA polymerase II promoter|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity - - - - 2:127941217-128028120 147 181 176 920 1030 801 1.50199779149169 1.68077886768301 1.62135926014829 8.42241755506493 8.6348863979426 7.67031361242819 1.60137863977433 8.24253918847857 -2.36377437324659 3.16810648270647e-26 4.95186654108476e-24 DOWN ENSG00000140025 EFCAB11 EF-hand calcium binding domain 11 [Source:HGNC Symbol;Acc:HGNC:20357] GO:0005488|GO:0043167|GO:0043169|GO:0046872|GO:0005509 binding|ion binding|cation binding|metal ion binding|calcium ion binding - - - - 14:89794669-89954777 9 13 21 184 189 181 0.0455879124244851 0.059847142977857 0.0959044552634526 0.835065676361283 0.785481001373363 0.859233853571458 0.0671131702219316 0.826593510435368 -3.62251022483088 3.64031443515055e-26 5.66030974723877e-24 DOWN ENSG00000146918 NCAPG2 non-SMC condensin II complex subunit G2 [Source:HGNC Symbol;Acc:HGNC:21904] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0008283|GO:0043229|GO:0016043|GO:0043227|GO:0048589|GO:0005622|GO:0005515|GO:0048856|GO:0007049|GO:0001824|GO:0042393|GO:0022402|GO:0007275|GO:0043231|GO:0001833|GO:0001832|GO:0051301|GO:0006996|GO:0051276|GO:1903047|GO:0009790|GO:0000278|GO:0031981|GO:0005654|GO:0007067|GO:0035064|GO:0005634|GO:0030261|GO:0009792|GO:0071103|GO:0006323|GO:0043009|GO:0001701 developmental process|growth|cell|membrane|cellular process|binding|cell proliferation|intracellular organelle|cellular component organization|membrane-bounded organelle|developmental growth|intracellular|protein binding|anatomical structure development|cell cycle|blastocyst development|histone binding|cell cycle process|multicellular organism development|intracellular membrane-bounded organelle|inner cell mass cell proliferation|blastocyst growth|cell division|organelle organization|chromosome organization|mitotic cell cycle process|embryo development|mitotic cell cycle|nuclear lumen|nucleoplasm|mitotic nuclear division|methylated histone binding|nucleus|chromosome condensation|embryo development ending in birth or egg hatching|DNA conformation change|DNA packaging|chordate embryonic development|in utero embryonic development - - - - 7:158631311-158704829 513 628 778 3212 3649 2791 3.83472550423815 4.26635174415845 5.24337485308275 21.5124630586985 22.37993158337 19.5526487752397 4.44815070049312 21.1483478057694 -2.24926738700724 3.81564848957675e-26 5.90219533719296e-24 DOWN ENSG00000145284 SCD5 stearoyl-CoA desaturase 5 [Source:HGNC Symbol;Acc:HGNC:21088] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0044255|GO:0006082|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0055114|GO:0046872|GO:0006631|GO:0016717|GO:0008610|GO:0033559|GO:0006633|GO:0019752|GO:0006636|GO:0032787|GO:0004768 cell|membrane|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|oxidation-reduction process|metal ion binding|fatty acid metabolic process|oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water|lipid biosynthetic process|unsaturated fatty acid metabolic process|fatty acid biosynthetic process|carboxylic acid metabolic process|unsaturated fatty acid biosynthetic process|monocarboxylic acid metabolic process|stearoyl-CoA 9-desaturase activity K00507 stearoyl-CoA desaturase (delta-9 desaturase)[1.14.19.1] hsa04152|hsa03320|hsa01212|hsa01040 AMPK signaling pathway - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Fatty acid metabolism - Homo sapiens (human)|Biosynthesis of unsaturated fatty acids - Homo sapiens (human) 4:82629539-82798857 81 64 107 544 628 627 1.2039749470627 0.864548714658636 1.43393248429586 7.24480556635874 7.65874260084312 8.7342678275602 1.16748538200573 7.87927199825402 -2.75465785251344 4.15268824422525e-26 6.3904306620155e-24 DOWN ENSG00000169902 TPST1 tyrosylprotein sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:12020] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006952|GO:0043231|GO:0005737|GO:0016021|GO:0019538|GO:0005794|GO:0006790|GO:0043412|GO:0036211|GO:0006954|GO:0044267|GO:0008146|GO:0000139|GO:0051923|GO:0008476|GO:0006477|GO:0006464|GO:0018193|GO:0006478 cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|defense response|intracellular membrane-bounded organelle|cytoplasm|integral component of membrane|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|macromolecule modification|protein modification process|inflammatory response|cellular protein metabolic process|sulfotransferase activity|Golgi membrane|sulfation|protein-tyrosine sulfotransferase activity|protein sulfation|cellular protein modification process|peptidyl-amino acid modification|peptidyl-tyrosine sulfation - - - - 7:66205199-66420543 11 13 14 186 155 207 0.191368008584423 0.205549766769743 0.219599785527297 2.89927542439719 2.21247076861685 3.37502255169633 0.205505853627154 2.82892291490346 -3.78300147206749 4.63597961625217e-26 7.09756592120986e-24 DOWN ENSG00000140948 ZCCHC14 zinc finger, CCHC domain containing 14 [Source:HGNC Symbol;Acc:HGNC:24134] GO:0005488|GO:0097159|GO:0043167|GO:0008289|GO:0005515|GO:0003676|GO:0043168|GO:0005543|GO:0043169|GO:0046872|GO:0035091|GO:0046914|GO:0008270 binding|organic cyclic compound binding|ion binding|lipid binding|protein binding|nucleic acid binding|anion binding|phospholipid binding|cation binding|metal ion binding|phosphatidylinositol binding|transition metal ion binding|zinc ion binding - - - - 16:87406246-87492045 134 125 180 744 930 997 0.740296880794783 0.627611932563383 0.896577816775498 3.68273597189815 4.21551819685454 5.16207506389662 0.754828876711221 4.35344307754977 -2.52793533902928 4.91337300531098e-26 7.48386927043643e-24 DOWN ENSG00000115919 KYNU kynureninase [Source:HGNC Symbol;Acc:HGNC:6469] GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0043227|GO:0048037|GO:0009605|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0042802|GO:0006575|GO:0045087|GO:0006725|GO:1901360|GO:0006082|GO:0009991|GO:0034641|GO:0043168|GO:0044281|GO:0006952|GO:0019637|GO:0046483|GO:0043231|GO:0010243|GO:0005737|GO:0006520|GO:0046983|GO:0051186|GO:0006139|GO:0055086|GO:0042180|GO:0030170|GO:0044249|GO:0010033|GO:0006790|GO:0007584|GO:0005829|GO:0034097|GO:0006637|GO:0009308|GO:0033273|GO:0009072|GO:0034341|GO:0031981|GO:0009063|GO:0005654|GO:0005739|GO:0042182|GO:0014070|GO:0006796|GO:0019439|GO:0034516|GO:0042219|GO:0031667|GO:0070189|GO:0005634|GO:0042803|GO:0006568|GO:0009074|GO:0019441|GO:0009117|GO:0046395|GO:0097053|GO:0009108|GO:0046874|GO:0006576|GO:0019752|GO:0097052|GO:0043420|GO:0009165|GO:0030429|GO:0006084|GO:0043648|GO:0006569|GO:0032787|GO:0019363|GO:0019805|GO:0019442|GO:0034354|GO:0019674|GO:0009435 immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|membrane-bounded organelle|cofactor binding|response to external stimulus|hydrolase activity|biosynthetic process|intracellular|protein binding|identical protein binding|cellular modified amino acid metabolic process|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|response to extracellular stimulus|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|defense response|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|protein dimerization activity|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cellular ketone metabolic process|pyridoxal phosphate binding|cellular biosynthetic process|response to organic substance|sulfur compound metabolic process|response to nutrient|cytosol|response to cytokine|acyl-CoA metabolic process|amine metabolic process|response to vitamin|aromatic amino acid family metabolic process|response to interferon-gamma|nuclear lumen|cellular amino acid catabolic process|nucleoplasm|mitochondrion|ketone catabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|aromatic compound catabolic process|response to vitamin B6|cellular modified amino acid catabolic process|response to nutrient levels|kynurenine metabolic process|nucleus|protein homodimerization activity|tryptophan metabolic process|aromatic amino acid family catabolic process|tryptophan catabolic process to kynurenine|nucleotide metabolic process|carboxylic acid catabolic process|L-kynurenine catabolic process|coenzyme biosynthetic process|quinolinate metabolic process|cellular biogenic amine metabolic process|carboxylic acid metabolic process|L-kynurenine metabolic process|anthranilate metabolic process|nucleotide biosynthetic process|kynureninase activity|acetyl-CoA metabolic process|dicarboxylic acid metabolic process|tryptophan catabolic process|monocarboxylic acid metabolic process|pyridine nucleotide biosynthetic process|quinolinate biosynthetic process|tryptophan catabolic process to acetyl-CoA|'de novo' NAD biosynthetic process from tryptophan|NAD metabolic process|NAD biosynthetic process K01556 kynureninase[3.7.1.3] hsa01100|hsa00380 Metabolic pathways - Homo sapiens (human)|Tryptophan metabolism - Homo sapiens (human) 2:142877498-143055832 672 801 919 3765 3968 3436 2.60167155122766 2.81835806684408 3.20784455952168 13.0600877472016 12.6044245759228 12.4671036570797 2.87595805919781 12.710538660068 -2.14391062976121 5.09013673179603e-26 7.71375340056034e-24 DOWN ENSG00000067900 ROCK1 Rho-associated, coiled-coil containing protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:10251] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0044089|GO:0071704|GO:0050900|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0031252|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0048514|GO:0016337|GO:0006935|GO:0045595|GO:0009888|GO:0045123|GO:0048468|GO:0051130|GO:0001568|GO:0010941|GO:0007275|GO:0048513|GO:0043168|GO:0097194|GO:0030155|GO:1901890|GO:0001882|GO:0016772|GO:0051128|GO:0032059|GO:0022607|GO:0098609|GO:0051098|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0032970|GO:0003012|GO:0001726|GO:0006928|GO:0022406|GO:1901888|GO:0031589|GO:0030027|GO:0045184|GO:0060548|GO:0032231|GO:0001525|GO:0008104|GO:0007163|GO:0007154|GO:0044092|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0045785|GO:0008219|GO:0050790|GO:0000166|GO:0030030|GO:0043086|GO:0048869|GO:0030029|GO:2000145|GO:0032878|GO:0019538|GO:0031324|GO:0031323|GO:0010256|GO:0005794|GO:0006996|GO:0051017|GO:0016525|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0005813|GO:0045682|GO:0006936|GO:0045216|GO:1901215|GO:0090150|GO:2000114|GO:0046872|GO:0007166|GO:0032956|GO:0051100|GO:0035639|GO:0001944|GO:0043412|GO:0007010|GO:0072358|GO:0022614|GO:0043069|GO:0002064|GO:0005815|GO:0030048|GO:0001883|GO:0070997|GO:0000904|GO:0050901|GO:0007009|GO:0005814|GO:0036211|GO:0032269|GO:0030856|GO:0007160|GO:0032549|GO:0034329|GO:2000810|GO:0072657|GO:0030010|GO:0045765|GO:0030031|GO:0007159|GO:0010810|GO:0051346|GO:0016301|GO:0043588|GO:1901214|GO:0030036|GO:0034613|GO:0012501|GO:0060429|GO:0006796|GO:1901342|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:1903393|GO:0097485|GO:0000139|GO:0017076|GO:0051246|GO:0051894|GO:0006921|GO:0051020|GO:0010811|GO:0030154|GO:0048858|GO:0072359|GO:0016773|GO:0005856|GO:0051492|GO:0043067|GO:0043393|GO:0048666|GO:0030182|GO:0003158|GO:0007411|GO:0051451|GO:0010923|GO:0016311|GO:0070252|GO:0001885|GO:0006939|GO:0030855|GO:0043523|GO:0034332|GO:0072659|GO:0030866|GO:0090002|GO:1903347|GO:0005524|GO:0030216|GO:0030554|GO:0016310|GO:0008544|GO:0045604|GO:0061564|GO:0003382|GO:0051493|GO:0032060|GO:0007167|GO:0001952|GO:0030865|GO:0007044|GO:0015630|GO:0007249|GO:0031267|GO:0001954|GO:0042981|GO:0048041|GO:0043066|GO:0004672|GO:0051402|GO:0043524|GO:0031032|GO:0022008|GO:0030038|GO:0048667|GO:0007264|GO:0051893|GO:0006464|GO:0045601|GO:0007015|GO:0048812|GO:0032091|GO:0007043|GO:1990778|GO:0006915|GO:0034333|GO:0010921|GO:0006470|GO:0035304|GO:0070830|GO:0045616|GO:0061028|GO:0045446|GO:0007265|GO:0017016|GO:0043297|GO:0007409|GO:0003383|GO:0006468|GO:0048699|GO:1903140|GO:0043666|GO:0043149|GO:0004674|GO:0035305|GO:0061572|GO:0032515|GO:0035303|GO:0035308|GO:0007169|GO:0009913|GO:0048010|GO:0017048|GO:0035509|GO:0035507|GO:0048013|GO:0007266|GO:0017049 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of cellular component biogenesis|organic substance metabolic process|leukocyte migration|ion binding|cellular metabolic process|cellular localization|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|cell leading edge|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|single organismal cell-cell adhesion|chemotaxis|regulation of cell differentiation|tissue development|cellular extravasation|cell development|positive regulation of cellular component organization|blood vessel development|regulation of cell death|multicellular organism development|animal organ development|anion binding|execution phase of apoptosis|regulation of cell adhesion|positive regulation of cell junction assembly|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|bleb|cellular component assembly|cell-cell adhesion|regulation of binding|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|regulation of actin filament-based process|muscle system process|ruffle|movement of cell or subcellular component|membrane docking|regulation of cell junction assembly|cell-substrate adhesion|lamellipodium|establishment of protein localization|negative regulation of cell death|regulation of actin filament bundle assembly|angiogenesis|protein localization|establishment or maintenance of cell polarity|cell communication|negative regulation of molecular function|membrane organization|regulation of cellular component movement|cell migration|signal transduction|positive regulation of cell adhesion|cell death|regulation of catalytic activity|nucleotide binding|cell projection organization|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|regulation of cell motility|regulation of establishment or maintenance of cell polarity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|actin filament bundle assembly|negative regulation of angiogenesis|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|centrosome|regulation of epidermis development|muscle contraction|cell-cell junction organization|negative regulation of neuron death|establishment of protein localization to membrane|regulation of establishment of cell polarity|metal ion binding|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|negative regulation of binding|purine ribonucleoside triphosphate binding|vasculature development|macromolecule modification|cytoskeleton organization|cardiovascular system development|membrane to membrane docking|negative regulation of programmed cell death|epithelial cell development|microtubule organizing center|actin filament-based movement|purine nucleoside binding|neuron death|cell morphogenesis involved in differentiation|leukocyte tethering or rolling|plasma membrane organization|centriole|protein modification process|negative regulation of cellular protein metabolic process|regulation of epithelial cell differentiation|cell-matrix adhesion|ribonucleoside binding|cell junction assembly|regulation of bicellular tight junction assembly|protein localization to membrane|establishment of cell polarity|regulation of angiogenesis|cell projection assembly|leukocyte cell-cell adhesion|regulation of cell-substrate adhesion|negative regulation of hydrolase activity|kinase activity|skin development|regulation of neuron death|actin cytoskeleton organization|cellular protein localization|programmed cell death|epithelium development|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|positive regulation of adherens junction organization|neuron projection guidance|Golgi membrane|purine nucleotide binding|regulation of protein metabolic process|positive regulation of focal adhesion assembly|cellular component disassembly involved in execution phase of apoptosis|GTPase binding|positive regulation of cell-substrate adhesion|cell differentiation|cell projection morphogenesis|circulatory system development|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|regulation of stress fiber assembly|regulation of programmed cell death|regulation of protein binding|neuron development|neuron differentiation|endothelium development|axon guidance|myoblast migration|negative regulation of phosphatase activity|dephosphorylation|actin-mediated cell contraction|endothelial cell development|smooth muscle contraction|epithelial cell differentiation|regulation of neuron apoptotic process|adherens junction organization|protein localization to plasma membrane|cortical actin cytoskeleton organization|establishment of protein localization to plasma membrane|negative regulation of bicellular tight junction assembly|ATP binding|keratinocyte differentiation|adenyl nucleotide binding|phosphorylation|epidermis development|regulation of epidermal cell differentiation|axon development|epithelial cell morphogenesis|regulation of cytoskeleton organization|bleb assembly|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|cortical cytoskeleton organization|cell-substrate junction assembly|microtubule cytoskeleton|I-kappaB kinase/NF-kappaB signaling|small GTPase binding|positive regulation of cell-matrix adhesion|regulation of apoptotic process|focal adhesion assembly|negative regulation of apoptotic process|protein kinase activity|neuron apoptotic process|negative regulation of neuron apoptotic process|actomyosin structure organization|neurogenesis|contractile actin filament bundle assembly|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|regulation of focal adhesion assembly|cellular protein modification process|regulation of endothelial cell differentiation|actin filament organization|neuron projection morphogenesis|negative regulation of protein binding|cell-cell junction assembly|protein localization to cell periphery|apoptotic process|adherens junction assembly|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|bicellular tight junction assembly|regulation of keratinocyte differentiation|establishment of endothelial barrier|endothelial cell differentiation|Ras protein signal transduction|Ras GTPase binding|apical junction assembly|axonogenesis|apical constriction|protein phosphorylation|generation of neurons|regulation of establishment of endothelial barrier|regulation of phosphoprotein phosphatase activity|stress fiber assembly|protein serine/threonine kinase activity|negative regulation of dephosphorylation|actin filament bundle organization|negative regulation of phosphoprotein phosphatase activity|regulation of dephosphorylation|negative regulation of protein dephosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|epidermal cell differentiation|vascular endothelial growth factor receptor signaling pathway|Rho GTPase binding|negative regulation of myosin-light-chain-phosphatase activity|regulation of myosin-light-chain-phosphatase activity|ephrin receptor signaling pathway|Rho protein signal transduction|GTP-Rho binding K04514 Rho-associated protein kinase 1[2.7.11.1] hsa05200|hsa05206|hsa04810|hsa05205|hsa04510|hsa04024|hsa04062|hsa04360|hsa04022|hsa04921|hsa04611|hsa04270|hsa04071|hsa04670|hsa05132|hsa04350|hsa05131|hsa05130 Pathways in cancer - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human) 18:20946906-21111851 220 218 311 1162 1373 1230 1.11285130999958 1.00219049293744 1.41836910457129 5.26645095243651 5.69839842925825 5.83107063382448 1.1778036358361 5.59864000517308 -2.24897738496517 5.26090494888695e-26 7.93227557293287e-24 DOWN ENSG00000153250 RBMS1 RNA binding motif, single stranded interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:9907] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0000166|GO:0044249|GO:0003677|GO:0034645|GO:0003723|GO:0006259|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006260|GO:0006396|GO:0003697|GO:0003690|GO:0044822 cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|DNA binding|cellular macromolecule biosynthetic process|RNA binding|DNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|DNA replication|RNA processing|single-stranded DNA binding|double-stranded DNA binding|poly(A) RNA binding - - - - 2:160272151-160493794 103 159 251 1076 1328 1213 0.377469765769347 0.529567477734427 0.829336710541695 3.53307891147656 3.99309204740863 4.16613268254479 0.578791318015156 3.89743454714333 -2.75140960831783 7.30298428948712e-26 1.09559443707713e-23 DOWN ENSG00000204217 BMPR2 bone morphogenetic protein receptor type II [Source:HGNC Symbol;Acc:HGNC:1078] GO:0040011|GO:0032502|GO:0040007|GO:0004871|GO:0000003|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0004872|GO:0009892|GO:0045178|GO:0048523|GO:0008283|GO:0050794|GO:0060076|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0005057|GO:0048520|GO:0044702|GO:0071704|GO:0043167|GO:0009986|GO:0044237|GO:0050795|GO:0045177|GO:0038023|GO:0003006|GO:0048870|GO:0023051|GO:0045926|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0045927|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0005615|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0048646|GO:0048609|GO:0019222|GO:0001946|GO:0001893|GO:0008284|GO:0051272|GO:0042127|GO:0001890|GO:0035988|GO:0048286|GO:0006935|GO:0045595|GO:0006725|GO:0060041|GO:0009888|GO:0048468|GO:0043025|GO:0019838|GO:0016323|GO:0009925|GO:0044214|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0016324|GO:0009991|GO:0044853|GO:0007275|GO:0010632|GO:0030324|GO:0048513|GO:0032535|GO:0001945|GO:0034641|GO:0043168|GO:0030307|GO:0061036|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0090287|GO:0007420|GO:0070169|GO:0005887|GO:0045597|GO:0048608|GO:0043169|GO:0004888|GO:0030308|GO:0005737|GO:0007389|GO:0031668|GO:0060322|GO:0050920|GO:0007423|GO:0006928|GO:0009887|GO:0043005|GO:0009966|GO:0048729|GO:0048598|GO:0050673|GO:0048771|GO:0009890|GO:0048639|GO:0036477|GO:0097481|GO:0014069|GO:0060135|GO:0030323|GO:0010646|GO:0006139|GO:0031226|GO:0007154|GO:0001704|GO:0045778|GO:0007565|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0030278|GO:0048638|GO:0001503|GO:0019955|GO:0004702|GO:0008219|GO:0010634|GO:0060348|GO:0008285|GO:0008217|GO:0000166|GO:0036303|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0001558|GO:0031324|GO:0031323|GO:0003013|GO:0042594|GO:0050921|GO:0060560|GO:0050679|GO:0030501|GO:0005901|GO:0032268|GO:0000902|GO:0036122|GO:0031175|GO:1902731|GO:0048705|GO:0031344|GO:0035150|GO:0010468|GO:0090132|GO:0071773|GO:0034645|GO:0051053|GO:0051216|GO:0046872|GO:0007166|GO:0001654|GO:0035639|GO:0001944|GO:0043412|GO:0061458|GO:0072358|GO:0007417|GO:0010720|GO:0007498|GO:0051252|GO:0060541|GO:0002063|GO:0001883|GO:0045667|GO:0031346|GO:0031214|GO:0000904|GO:0009790|GO:0010628|GO:0030334|GO:0001935|GO:0001667|GO:0009100|GO:0036211|GO:0060840|GO:0007369|GO:0032549|GO:0001649|GO:0045906|GO:0003002|GO:0001707|GO:0050769|GO:0045776|GO:0030425|GO:0008361|GO:0051247|GO:0070848|GO:0022604|GO:0006259|GO:0050678|GO:0009267|GO:0016301|GO:0001974|GO:0045669|GO:0032270|GO:0014916|GO:0012501|GO:0060429|GO:0006796|GO:1901137|GO:0044267|GO:0051174|GO:0010467|GO:0030516|GO:0032990|GO:0060841|GO:0007399|GO:0071310|GO:0060349|GO:0097485|GO:0017076|GO:0010594|GO:0031328|GO:0030510|GO:0051246|GO:0010770|GO:0061298|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0045121|GO:0060173|GO:0030335|GO:0061035|GO:0031669|GO:0016070|GO:0072359|GO:0031667|GO:0016773|GO:0008015|GO:1902667|GO:0010557|GO:0030282|GO:0060836|GO:1990138|GO:0048332|GO:0051960|GO:0010595|GO:0003073|GO:0045773|GO:0030500|GO:0048666|GO:0030182|GO:0003158|GO:0007411|GO:0009101|GO:0045893|GO:0010975|GO:0060393|GO:0031401|GO:2000279|GO:0030855|GO:0010769|GO:0060350|GO:0043010|GO:0048841|GO:0002062|GO:0032774|GO:0005524|GO:2001141|GO:0071363|GO:0030554|GO:0016310|GO:0003085|GO:0004675|GO:0019229|GO:0061564|GO:0001936|GO:0048842|GO:2000278|GO:0030509|GO:0007167|GO:0010862|GO:0010631|GO:0009952|GO:0006029|GO:0001938|GO:0004672|GO:0050772|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0071897|GO:0010976|GO:0006351|GO:0006915|GO:0006355|GO:0048675|GO:0030513|GO:0050880|GO:0045666|GO:0045944|GO:0045446|GO:0006366|GO:0017002|GO:0006357|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0042325|GO:0001932|GO:0042310|GO:0004674|GO:0001934|GO:0007178|GO:0030166|GO:0048846|GO:0043542|GO:0050770|GO:0045664|GO:0042327|GO:0007169|GO:0072577|GO:0048010|GO:0032924|GO:0060389|GO:0016362 locomotion|developmental process|growth|signal transducer activity|reproduction|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|basal part of cell|negative regulation of cellular process|cell proliferation|regulation of cellular process|excitatory synapse|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|receptor signaling protein activity|positive regulation of behavior|single organism reproductive process|organic substance metabolic process|ion binding|cell surface|cellular metabolic process|regulation of behavior|apical part of cell|signaling receptor activity|developmental process involved in reproduction|cell motility|regulation of signaling|negative regulation of growth|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|extracellular space|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|lymphangiogenesis|maternal placenta development|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|placenta development|chondrocyte proliferation|lung alveolus development|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|retina development in camera-type eye|tissue development|cell development|neuronal cell body|growth factor binding|basolateral plasma membrane|basal plasma membrane|spanning component of plasma membrane|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|apical plasma membrane|response to extracellular stimulus|plasma membrane raft|multicellular organism development|regulation of epithelial cell migration|lung development|animal organ development|regulation of cellular component size|lymph vessel development|cellular nitrogen compound metabolic process|anion binding|positive regulation of cell growth|positive regulation of cartilage development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|regulation of cellular response to growth factor stimulus|brain development|positive regulation of biomineral tissue development|integral component of plasma membrane|positive regulation of cell differentiation|reproductive structure development|cation binding|transmembrane signaling receptor activity|negative regulation of cell growth|cytoplasm|pattern specification process|cellular response to extracellular stimulus|head development|regulation of chemotaxis|sensory organ development|movement of cell or subcellular component|organ morphogenesis|neuron projection|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|epithelial cell proliferation|tissue remodeling|negative regulation of biosynthetic process|positive regulation of developmental growth|somatodendritic compartment|neuronal postsynaptic density|postsynaptic density|maternal process involved in female pregnancy|respiratory tube development|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|cell communication|formation of primary germ layer|positive regulation of ossification|female pregnancy|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|regulation of ossification|regulation of developmental growth|ossification|cytokine binding|receptor signaling protein serine/threonine kinase activity|cell death|positive regulation of epithelial cell migration|bone development|negative regulation of cell proliferation|regulation of blood pressure|nucleotide binding|lymph vessel morphogenesis|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|response to starvation|positive regulation of chemotaxis|developmental growth involved in morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of bone mineralization|caveola|regulation of cellular protein metabolic process|cell morphogenesis|BMP binding|neuron projection development|negative regulation of chondrocyte proliferation|skeletal system morphogenesis|regulation of cell projection organization|regulation of tube size|regulation of gene expression|epithelium migration|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|cartilage development|metal ion binding|cell surface receptor signaling pathway|eye development|purine ribonucleoside triphosphate binding|vasculature development|macromolecule modification|reproductive system development|cardiovascular system development|central nervous system development|positive regulation of cell development|mesoderm development|regulation of RNA metabolic process|respiratory system development|chondrocyte development|purine nucleoside binding|regulation of osteoblast differentiation|positive regulation of cell projection organization|biomineral tissue development|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|glycoprotein metabolic process|protein modification process|artery development|gastrulation|ribonucleoside binding|osteoblast differentiation|negative regulation of vasoconstriction|regionalization|mesoderm formation|positive regulation of neurogenesis|negative regulation of blood pressure|dendrite|regulation of cell size|positive regulation of protein metabolic process|response to growth factor|regulation of cell morphogenesis|DNA metabolic process|regulation of epithelial cell proliferation|cellular response to starvation|kinase activity|blood vessel remodeling|positive regulation of osteoblast differentiation|positive regulation of cellular protein metabolic process|regulation of lung blood pressure|programmed cell death|epithelium development|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of axon extension|cell part morphogenesis|venous blood vessel development|nervous system development|cellular response to organic substance|bone morphogenesis|neuron projection guidance|purine nucleotide binding|regulation of endothelial cell migration|positive regulation of cellular biosynthetic process|regulation of BMP signaling pathway|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|retina vasculature development in camera-type eye|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|membrane raft|limb development|positive regulation of cell migration|regulation of cartilage development|cellular response to nutrient levels|RNA metabolic process|circulatory system development|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|blood circulation|regulation of axon guidance|positive regulation of macromolecule biosynthetic process|bone mineralization|lymphatic endothelial cell differentiation|neuron projection extension|mesoderm morphogenesis|regulation of nervous system development|positive regulation of endothelial cell migration|regulation of systemic arterial blood pressure|positive regulation of axon extension|regulation of bone mineralization|neuron development|neuron differentiation|endothelium development|axon guidance|glycoprotein biosynthetic process|positive regulation of transcription, DNA-templated|regulation of neuron projection development|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein modification process|negative regulation of DNA biosynthetic process|epithelial cell differentiation|regulation of cell morphogenesis involved in differentiation|endochondral bone morphogenesis|camera-type eye development|regulation of axon extension involved in axon guidance|chondrocyte differentiation|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|negative regulation of systemic arterial blood pressure|transmembrane receptor protein serine/threonine kinase activity|regulation of vasoconstriction|axon development|regulation of endothelial cell proliferation|positive regulation of axon extension involved in axon guidance|regulation of DNA biosynthetic process|BMP signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|epithelial cell migration|anterior/posterior pattern specification|proteoglycan metabolic process|positive regulation of endothelial cell proliferation|protein kinase activity|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|DNA biosynthetic process|positive regulation of neuron projection development|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|axon extension|positive regulation of BMP signaling pathway|regulation of blood vessel size|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|activin-activated receptor activity|regulation of transcription from RNA polymerase II promoter|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|vasoconstriction|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|proteoglycan biosynthetic process|axon extension involved in axon guidance|endothelial cell migration|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|endothelial cell apoptotic process|vascular endothelial growth factor receptor signaling pathway|activin receptor signaling pathway|pathway-restricted SMAD protein phosphorylation|activin receptor activity, type II K04671 bone morphogenetic protein receptor type-2[2.7.11.30] hsa04060|hsa05206|hsa04360|hsa04390|hsa04550|hsa04350 Cytokine-cytokine receptor interaction - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human) 2:202376936-202567751 91 130 187 793 957 1121 0.529188786793247 0.687056007092982 0.98045012790148 4.13180836769161 4.5661381684574 6.10947293484668 0.732231640595903 4.9358064903319 -2.75291381367276 7.49360989795172e-26 1.11857114946725e-23 DOWN ENSG00000185420 SMYD3 SET and MYND domain containing 3 [Source:HGNC Symbol;Acc:HGNC:15513] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0006725|GO:0048468|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0022607|GO:0061061|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0032403|GO:0045184|GO:0006139|GO:0008104|GO:0044092|GO:0009725|GO:0050790|GO:0043086|GO:0048869|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0003677|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0043412|GO:0042692|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0010628|GO:0036211|GO:0032269|GO:0070063|GO:0031981|GO:0051247|GO:0005654|GO:0006461|GO:0055001|GO:0032270|GO:0014070|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0000993|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0097305|GO:0055002|GO:0000975|GO:0045893|GO:0031401|GO:0006334|GO:0034622|GO:0032774|GO:0043565|GO:2001141|GO:0034728|GO:0016310|GO:0043175|GO:0071383|GO:0071407|GO:0003690|GO:0006333|GO:0018022|GO:0065004|GO:0008276|GO:0034968|GO:0031497|GO:0051146|GO:0016568|GO:0033673|GO:0006464|GO:0071396|GO:0008757|GO:0031960|GO:0071103|GO:0043549|GO:0071548|GO:0006351|GO:0008170|GO:0006355|GO:0006323|GO:0051384|GO:0045944|GO:0006366|GO:0045859|GO:0006469|GO:0006357|GO:0071549|GO:0016279|GO:0006468|GO:1903506|GO:0044212|GO:0042325|GO:0001932|GO:0018193|GO:0042054|GO:0042326|GO:0014902|GO:0071384|GO:0001934|GO:0014904|GO:0001933|GO:0042327|GO:0018024|GO:0044213|GO:0071385|GO:0001047|GO:0000976|GO:0001012|GO:0033138|GO:0018105|GO:0033135|GO:0018205|GO:0001046|GO:0000977|GO:0001161|GO:0001162|GO:0000979 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|methylation|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|muscle structure development|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|protein complex binding|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|negative regulation of molecular function|response to hormone|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|DNA binding|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|macromolecule modification|muscle cell differentiation|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|RNA polymerase binding|nuclear lumen|positive regulation of protein metabolic process|nucleoplasm|protein complex assembly|muscle cell development|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|RNA polymerase II core binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|response to alcohol|striated muscle cell development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|nucleosome assembly|cellular macromolecular complex assembly|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nucleosome organization|phosphorylation|RNA polymerase core enzyme binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|chromatin assembly or disassembly|peptidyl-lysine methylation|protein-DNA complex assembly|protein methyltransferase activity|histone lysine methylation|chromatin assembly|striated muscle cell differentiation|chromatin modification|negative regulation of kinase activity|cellular protein modification process|cellular response to lipid|S-adenosylmethionine-dependent methyltransferase activity|response to corticosteroid|DNA conformation change|regulation of kinase activity|response to dexamethasone|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|DNA packaging|response to glucocorticoid|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|negative regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|cellular response to dexamethasone stimulus|protein-lysine N-methyltransferase activity|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|histone methyltransferase activity|negative regulation of phosphorylation|myotube differentiation|cellular response to corticosteroid stimulus|positive regulation of protein phosphorylation|myotube cell development|negative regulation of protein phosphorylation|positive regulation of phosphorylation|histone-lysine N-methyltransferase activity|intronic transcription regulatory region DNA binding|cellular response to glucocorticoid stimulus|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|positive regulation of peptidyl-serine phosphorylation|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|peptidyl-lysine modification|core promoter sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|intronic transcription regulatory region sequence-specific DNA binding|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding - - - - 1:245749342-246507312 61 51 105 528 631 650 0.544202201180377 0.41350521259811 0.84456155741841 4.22044848639071 4.61875237719972 5.43462785790108 0.600756323732299 4.75794290716384 -2.98548612551109 7.65836444980466e-26 1.13747667803218e-23 DOWN ENSG00000164347 GFM2 G elongation factor, mitochondrial 2 [Source:HGNC Symbol;Acc:HGNC:29682] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0034641|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005737|GO:0000166|GO:0044249|GO:0019538|GO:0006996|GO:0034645|GO:0006518|GO:1903008|GO:0035639|GO:0007005|GO:0001883|GO:0016818|GO:0032549|GO:0005759|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0032543|GO:0043241|GO:0032561|GO:0043043|GO:0032790|GO:0006412|GO:0005525|GO:0019001|GO:0016462|GO:0070126|GO:0043624|GO:0017111|GO:0006415|GO:0003924 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|nucleotide binding|cellular biosynthetic process|protein metabolic process|organelle organization|cellular macromolecule biosynthetic process|peptide metabolic process|organelle disassembly|purine ribonucleoside triphosphate binding|mitochondrion organization|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|mitochondrial matrix|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|mitochondrial translation|protein complex disassembly|guanyl ribonucleotide binding|peptide biosynthetic process|ribosome disassembly|translation|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|mitochondrial translational termination|cellular protein complex disassembly|nucleoside-triphosphatase activity|translational termination|GTPase activity - - - - 5:74721204-74767371 217 306 350 1351 1506 1417 2.03822585310254 2.61212514091027 2.96397788655771 11.3696208329818 11.6060948063441 12.4735994552574 2.53810962685684 11.8164383648611 -2.21896896415051 7.87062525662099e-26 1.16321607134239e-23 DOWN ENSG00000125821 DTD1 D-tyrosyl-tRNA deacylase 1 [Source:HGNC Symbol;Acc:HGNC:16219] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0006082|GO:0003676|GO:0034641|GO:0016788|GO:0044281|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006520|GO:0006139|GO:0006450|GO:0016021|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0009063|GO:0006259|GO:0043603|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0052689|GO:0043043|GO:0002161|GO:0006260|GO:0034660|GO:0046395|GO:0010608|GO:0046416|GO:0006412|GO:0006417|GO:0019752|GO:0006414|GO:0051500|GO:0006399|GO:0019478 cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|regulation of translational fidelity|integral component of membrane|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|cellular amino acid catabolic process|DNA metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|carboxylic ester hydrolase activity|peptide biosynthetic process|aminoacyl-tRNA editing activity|DNA replication|ncRNA metabolic process|carboxylic acid catabolic process|posttranscriptional regulation of gene expression|D-amino acid metabolic process|translation|regulation of translation|carboxylic acid metabolic process|translational elongation|D-tyrosyl-tRNA(Tyr) deacylase activity|tRNA metabolic process|D-amino acid catabolic process - - - - 20:18567453-18763917 84 87 88 659 818 493 1.65144089256294 1.55448185256724 1.55984854891699 11.6082833035979 13.1948869727145 9.08364714917685 1.58859043134906 11.2956058084964 -2.8299425240755 8.15130966396299e-26 1.19876452565493e-23 DOWN ENSG00000083535 PIBF1 progesterone immunomodulatory binding factor 1 [Source:HGNC Symbol;Acc:HGNC:23352] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0005615|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0001818|GO:0007049|GO:0044255|GO:0051640|GO:0022402|GO:0006082|GO:0005102|GO:0044281|GO:0031325|GO:0022607|GO:0001817|GO:0043231|GO:0005737|GO:0001816|GO:0051656|GO:0001775|GO:0009966|GO:0009890|GO:0001819|GO:0010646|GO:0043085|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0006629|GO:0007165|GO:0009968|GO:0042180|GO:0051649|GO:0002695|GO:0050790|GO:0007059|GO:0030030|GO:0045833|GO:0048869|GO:0009967|GO:0044249|GO:0007017|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:1902533|GO:0051249|GO:0032268|GO:0000902|GO:0005813|GO:0000819|GO:0005126|GO:0030101|GO:0070851|GO:1903047|GO:0043412|GO:0007080|GO:0007010|GO:0032613|GO:0006631|GO:0005815|GO:0032655|GO:0051055|GO:0032615|GO:0051347|GO:0036211|GO:0044782|GO:0032269|GO:0000278|GO:0051250|GO:0030031|GO:0032733|GO:0051247|GO:0007051|GO:0006461|GO:0034613|GO:0010565|GO:0070925|GO:0032270|GO:0006796|GO:0042384|GO:0035556|GO:0044267|GO:0051174|GO:0007067|GO:0032990|GO:0032695|GO:0008610|GO:0019216|GO:1902532|GO:0046890|GO:0045922|GO:0051246|GO:0048858|GO:1902531|GO:0000226|GO:0005856|GO:0005634|GO:0006690|GO:0051303|GO:0060271|GO:0019217|GO:0033559|GO:0051225|GO:0035058|GO:0033365|GO:0031401|GO:0005136|GO:0032815|GO:0016310|GO:0007052|GO:0015630|GO:0006633|GO:0000070|GO:0051310|GO:0045717|GO:0019752|GO:0034451|GO:0006464|GO:0046456|GO:0090307|GO:0042304|GO:0043549|GO:0033674|GO:0006636|GO:0007259|GO:0045859|GO:0045860|GO:0006468|GO:0046425|GO:0042325|GO:0044380|GO:0046426|GO:0001932|GO:0018193|GO:0042326|GO:0046427|GO:0031393|GO:0032787|GO:0001934|GO:0001933|GO:0042327|GO:0006693|GO:0050731|GO:0050730|GO:0007260|GO:0001516|GO:0042531|GO:0042976|GO:0050732|GO:0032147|GO:0018108|GO:0042521|GO:0071539|GO:0010531|GO:0042526 developmental process|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|extracellular space|intracellular|regulation of immune system process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|negative regulation of cytokine production|cell cycle|cellular lipid metabolic process|organelle localization|cell cycle process|organic acid metabolic process|receptor binding|small molecule metabolic process|positive regulation of cellular metabolic process|cellular component assembly|regulation of cytokine production|intracellular membrane-bounded organelle|cytoplasm|cytokine production|establishment of organelle localization|cell activation|regulation of signal transduction|negative regulation of biosynthetic process|positive regulation of cytokine production|regulation of cell communication|positive regulation of catalytic activity|protein localization|lymphocyte activation|regulation of cell activation|cell communication|lipid metabolic process|signal transduction|negative regulation of signal transduction|cellular ketone metabolic process|establishment of localization in cell|negative regulation of leukocyte activation|regulation of catalytic activity|chromosome segregation|cell projection organization|negative regulation of lipid metabolic process|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|microtubule-based process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cell morphogenesis|centrosome|sister chromatid segregation|cytokine receptor binding|natural killer cell activation|growth factor receptor binding|mitotic cell cycle process|macromolecule modification|mitotic metaphase plate congression|cytoskeleton organization|interleukin-10 production|fatty acid metabolic process|microtubule organizing center|regulation of interleukin-12 production|negative regulation of lipid biosynthetic process|interleukin-12 production|positive regulation of transferase activity|protein modification process|cilium organization|negative regulation of cellular protein metabolic process|mitotic cell cycle|negative regulation of lymphocyte activation|cell projection assembly|positive regulation of interleukin-10 production|positive regulation of protein metabolic process|spindle organization|protein complex assembly|cellular protein localization|regulation of cellular ketone metabolic process|organelle assembly|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cilium assembly|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|cell part morphogenesis|negative regulation of interleukin-12 production|lipid biosynthetic process|regulation of lipid metabolic process|negative regulation of intracellular signal transduction|regulation of lipid biosynthetic process|negative regulation of fatty acid metabolic process|regulation of protein metabolic process|cell projection morphogenesis|regulation of intracellular signal transduction|microtubule cytoskeleton organization|cytoskeleton|nucleus|icosanoid metabolic process|establishment of chromosome localization|cilium morphogenesis|regulation of fatty acid metabolic process|unsaturated fatty acid metabolic process|spindle assembly|nonmotile primary cilium assembly|protein localization to organelle|positive regulation of protein modification process|interleukin-4 receptor binding|negative regulation of natural killer cell activation|phosphorylation|mitotic spindle organization|microtubule cytoskeleton|fatty acid biosynthetic process|mitotic sister chromatid segregation|metaphase plate congression|negative regulation of fatty acid biosynthetic process|carboxylic acid metabolic process|centriolar satellite|cellular protein modification process|icosanoid biosynthetic process|mitotic spindle assembly|regulation of fatty acid biosynthetic process|regulation of kinase activity|positive regulation of kinase activity|unsaturated fatty acid biosynthetic process|JAK-STAT cascade|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of JAK-STAT cascade|regulation of phosphorylation|protein localization to cytoskeleton|negative regulation of JAK-STAT cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|positive regulation of JAK-STAT cascade|negative regulation of prostaglandin biosynthetic process|monocarboxylic acid metabolic process|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of phosphorylation|prostaglandin metabolic process|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|tyrosine phosphorylation of STAT protein|prostaglandin biosynthetic process|positive regulation of tyrosine phosphorylation of STAT protein|activation of Janus kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|activation of protein kinase activity|peptidyl-tyrosine phosphorylation|negative regulation of tyrosine phosphorylation of Stat4 protein|protein localization to centrosome|activation of JAK1 kinase activity|positive regulation of tyrosine phosphorylation of Stat6 protein - - - - 13:72782059-73016461 19 29 41 308 301 273 0.23939629969533 0.332091589766812 0.465764162688751 3.47713954769944 3.11176981252739 3.22377360600818 0.345750684050298 3.27089432207834 -3.24188113796775 8.46239254812051e-26 1.23841307417446e-23 DOWN ENSG00000151413 NUBPL nucleotide binding protein-like [Source:HGNC Symbol;Acc:HGNC:20278] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0048856|GO:0051536|GO:0043168|GO:0001882|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0000166|GO:0048869|GO:0006996|GO:0051539|GO:0046872|GO:0035639|GO:0007005|GO:0001883|GO:0097031|GO:0070584|GO:0032549|GO:0005739|GO:0006461|GO:0032990|GO:0017076|GO:0034622|GO:0032981|GO:0005524|GO:0043623|GO:0030554|GO:0033108|GO:0010257 developmental process|cell|cellular process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|anatomical structure development|iron-sulfur cluster binding|anion binding|nucleoside binding|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleotide binding|cellular developmental process|organelle organization|4 iron, 4 sulfur cluster binding|metal ion binding|purine ribonucleoside triphosphate binding|mitochondrion organization|purine nucleoside binding|mitochondrial respiratory chain complex I biogenesis|mitochondrion morphogenesis|ribonucleoside binding|mitochondrion|protein complex assembly|cell part morphogenesis|purine nucleotide binding|cellular macromolecular complex assembly|mitochondrial respiratory chain complex I assembly|ATP binding|cellular protein complex assembly|adenyl nucleotide binding|mitochondrial respiratory chain complex assembly|NADH dehydrogenase complex assembly - - - - 14:31489956-31861224 60 67 116 550 629 633 0.323689182408221 0.328499059179036 0.564220087443376 2.65850478995899 2.78416864437132 3.20043971784439 0.405469443010211 2.88103771739157 -2.82892344854453 1.04547641033242e-25 1.52251964653972e-23 DOWN ENSG00000197442 MAP3K5 mitogen-activated protein kinase kinase kinase 5 [Source:HGNC Symbol;Acc:HGNC:6857] GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0005057|GO:0042175|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0050793|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0016032|GO:0045087|GO:0045595|GO:0010941|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0033554|GO:0010942|GO:0061061|GO:0045597|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0002931|GO:0009966|GO:0046983|GO:0006979|GO:1990604|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0005783|GO:0004702|GO:0008219|GO:0050790|GO:0000166|GO:0048869|GO:0010035|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0051149|GO:0046872|GO:0035639|GO:0043412|GO:0051345|GO:0042542|GO:0042692|GO:0001883|GO:1901216|GO:0070997|GO:0051147|GO:0051347|GO:0036211|GO:0032549|GO:0019902|GO:0031098|GO:1990234|GO:0034599|GO:0051247|GO:0006508|GO:0016301|GO:1901214|GO:0019900|GO:0032270|GO:0012501|GO:0000302|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:0030154|GO:0043068|GO:1902531|GO:0004709|GO:0016773|GO:0034976|GO:0042803|GO:0043067|GO:0097190|GO:0070059|GO:0070304|GO:0097193|GO:0031401|GO:0008631|GO:0045445|GO:0043065|GO:0043408|GO:0045663|GO:0000287|GO:0005524|GO:0030162|GO:0045862|GO:0030554|GO:0016310|GO:0052547|GO:1902170|GO:0045661|GO:0019903|GO:0097300|GO:0043410|GO:0032872|GO:0042981|GO:0004672|GO:0034614|GO:0019901|GO:0006464|GO:0010952|GO:0051403|GO:0043549|GO:0070301|GO:0006915|GO:0033674|GO:0000186|GO:0045859|GO:0010950|GO:0045860|GO:0043406|GO:0046328|GO:1902911|GO:0043281|GO:0038066|GO:0006468|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0004674|GO:0032874|GO:0043280|GO:0001934|GO:0042327|GO:0052548|GO:0046330|GO:2001056|GO:0043507|GO:0000187|GO:0071902|GO:0071900|GO:0043506|GO:2000116|GO:0032147|GO:0007257 developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|receptor signaling protein activity|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|regulation of developmental process|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|viral process|innate immune response|regulation of cell differentiation|regulation of cell death|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|cellular response to stress|positive regulation of cell death|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|response to ischemia|regulation of signal transduction|protein dimerization activity|response to oxidative stress|IRE1-TRAF2-ASK1 complex|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|endoplasmic reticulum|receptor signaling protein serine/threonine kinase activity|cell death|regulation of catalytic activity|nucleotide binding|cellular developmental process|response to inorganic substance|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|positive regulation of muscle cell differentiation|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|positive regulation of hydrolase activity|response to hydrogen peroxide|muscle cell differentiation|purine nucleoside binding|positive regulation of neuron death|neuron death|regulation of muscle cell differentiation|positive regulation of transferase activity|protein modification process|ribonucleoside binding|phosphatase binding|stress-activated protein kinase signaling cascade|transferase complex|cellular response to oxidative stress|positive regulation of protein metabolic process|proteolysis|kinase activity|regulation of neuron death|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|response to reactive oxygen species|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|positive regulation of programmed cell death|regulation of intracellular signal transduction|MAP kinase kinase kinase activity|phosphotransferase activity, alcohol group as acceptor|response to endoplasmic reticulum stress|protein homodimerization activity|regulation of programmed cell death|apoptotic signaling pathway|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|positive regulation of stress-activated protein kinase signaling cascade|intrinsic apoptotic signaling pathway|positive regulation of protein modification process|intrinsic apoptotic signaling pathway in response to oxidative stress|myoblast differentiation|positive regulation of apoptotic process|regulation of MAPK cascade|positive regulation of myoblast differentiation|magnesium ion binding|ATP binding|regulation of proteolysis|positive regulation of proteolysis|adenyl nucleotide binding|phosphorylation|regulation of peptidase activity|cellular response to reactive nitrogen species|regulation of myoblast differentiation|protein phosphatase binding|programmed necrotic cell death|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|protein kinase activity|cellular response to reactive oxygen species|protein kinase binding|cellular protein modification process|positive regulation of peptidase activity|stress-activated MAPK cascade|regulation of kinase activity|cellular response to hydrogen peroxide|apoptotic process|positive regulation of kinase activity|activation of MAPKK activity|regulation of protein kinase activity|positive regulation of endopeptidase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of JNK cascade|protein kinase complex|regulation of cysteine-type endopeptidase activity involved in apoptotic process|p38MAPK cascade|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity|positive regulation of stress-activated MAPK cascade|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|positive regulation of phosphorylation|regulation of endopeptidase activity|positive regulation of JNK cascade|positive regulation of cysteine-type endopeptidase activity|positive regulation of JUN kinase activity|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|regulation of cysteine-type endopeptidase activity|activation of protein kinase activity|activation of JUN kinase activity K04426 mitogen-activated protein kinase kinase kinase 5[2.7.11.25] hsa04010|hsa04141|hsa04932|hsa04210|hsa04722|hsa04071|hsa04668|hsa05014 MAPK signaling pathway - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) 6:136557047-136792518 132 140 222 965 923 1151 1.73684786752233 1.67414849164243 2.63361738339806 11.3765697402723 9.96451390689767 14.1935422633572 2.01487124752094 11.8448753035091 -2.55550345372052 1.25792187156122e-25 1.82300968706742e-23 DOWN ENSG00000102893 PHKB phosphorylase kinase, beta [Source:HGNC Symbol;Acc:HGNC:8927] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0009056|GO:0044237|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0044262|GO:0015980|GO:0044281|GO:0016772|GO:0005737|GO:0005975|GO:0005516|GO:0006091|GO:0019538|GO:0055114|GO:0005829|GO:0005976|GO:0043412|GO:0005964|GO:0044275|GO:0036211|GO:1990234|GO:0005977|GO:0005996|GO:0016052|GO:0016301|GO:0006112|GO:0006796|GO:0044267|GO:0016773|GO:0019318|GO:0005980|GO:0016310|GO:0004672|GO:0006464|GO:0000272|GO:1902911|GO:0006468|GO:0006006|GO:0004674|GO:1902554|GO:0004683|GO:0004689 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|catabolic process|cellular metabolic process|cell periphery|intracellular|protein binding|plasma membrane|protein complex|transferase activity|cellular carbohydrate metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|cytoplasm|carbohydrate metabolic process|calmodulin binding|generation of precursor metabolites and energy|protein metabolic process|oxidation-reduction process|cytosol|polysaccharide metabolic process|macromolecule modification|phosphorylase kinase complex|cellular carbohydrate catabolic process|protein modification process|transferase complex|glycogen metabolic process|monosaccharide metabolic process|carbohydrate catabolic process|kinase activity|energy reserve metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|phosphotransferase activity, alcohol group as acceptor|hexose metabolic process|glycogen catabolic process|phosphorylation|protein kinase activity|cellular protein modification process|polysaccharide catabolic process|protein kinase complex|protein phosphorylation|glucose metabolic process|protein serine/threonine kinase activity|serine/threonine protein kinase complex|calmodulin-dependent protein kinase activity|phosphorylase kinase activity K07190 phosphorylase kinase alpha/beta subunit[-] hsa04020|hsa04910|hsa04922 Calcium signaling pathway - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human) 16:47461123-47701523 319 391 497 2059 2060 1846 1.2785445988539 1.42423738101728 1.79595770230296 7.39400438664783 6.77424426686573 6.93403924408495 1.49957989405805 7.03409596586617 -2.22980663010101 1.31767755184972e-25 1.90038384700103e-23 DOWN ENSG00000008869 HEATR5B HEAT repeat containing 5B [Source:HGNC Symbol;Acc:HGNC:29273] GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0005515|GO:0031982|GO:0070062 membrane|extracellular region|binding|extracellular vesicle|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 2:36968383-37084342 163 184 190 842 950 948 1.27771874763038 1.31082264877535 1.34280763936246 5.91366163397801 6.10995528059311 6.96440431007555 1.3104496785894 6.32934040821556 -2.27199320659615 1.52551157488022e-25 2.18954916136895e-23 DOWN ENSG00000164142 FAM160A1 family with sequence similarity 160 member A1 [Source:HGNC Symbol;Acc:HGNC:34237] - - - - - - 4:151409216-151663632 8 7 27 233 257 277 0.0818793956859095 0.0651195976286147 0.249164235238662 2.13677583139953 2.15826913897366 2.6571376823023 0.132054409517729 2.3173942175585 -4.13329910401309 1.70155591958899e-25 2.4305382977708e-23 DOWN ENSG00000118217 ATF6 activating transcription factor 6 [Source:HGNC Symbol;Acc:HGNC:791] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0000989|GO:0006457|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0042802|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0031227|GO:0019899|GO:0005737|GO:0005635|GO:0046983|GO:0006139|GO:0030176|GO:0007154|GO:0007165|GO:0005783|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0010033|GO:0031323|GO:0005794|GO:0003713|GO:0003677|GO:0010468|GO:0034645|GO:0030968|GO:0043620|GO:0006984|GO:0046982|GO:1901522|GO:0051252|GO:0010628|GO:0006986|GO:0031981|GO:0005654|GO:0044267|GO:0010467|GO:0071310|GO:0000139|GO:0031328|GO:0009059|GO:0035967|GO:0016070|GO:0034976|GO:0010557|GO:0005634|GO:0044389|GO:0034620|GO:0031625|GO:0000975|GO:0045893|GO:0006990|GO:0032774|GO:0043565|GO:2001141|GO:0036500|GO:0003690|GO:1990440|GO:0006351|GO:0006355|GO:0043618|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0036003|GO:0035497|GO:0000976|GO:0001012|GO:0000977 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|protein folding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|identical protein binding|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|enzyme binding|cytoplasm|nuclear envelope|protein dimerization activity|nucleobase-containing compound metabolic process|integral component of endoplasmic reticulum membrane|cell communication|signal transduction|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|transcription coactivator activity|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|endoplasmic reticulum unfolded protein response|regulation of DNA-templated transcription in response to stress|ER-nucleus signaling pathway|protein heterodimerization activity|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|regulation of RNA metabolic process|positive regulation of gene expression|response to unfolded protein|nuclear lumen|nucleoplasm|cellular protein metabolic process|gene expression|cellular response to organic substance|Golgi membrane|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cellular response to topologically incorrect protein|RNA metabolic process|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|nucleus|ubiquitin-like protein ligase binding|cellular response to unfolded protein|ubiquitin protein ligase binding|regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|ATF6-mediated unfolded protein response|double-stranded DNA binding|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter in response to stress|cAMP response element binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding K09054 cyclic AMP-dependent transcription factor ATF-6 alpha[-] hsa04141|hsa05010 Protein processing in endoplasmic reticulum - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human) 1:161766294-161964070 139 186 216 938 945 955 1.24021139580762 1.50825405987726 1.73760412329988 7.49864430885943 6.91802405123578 7.98572845970184 1.49535652632825 7.46746560659902 -2.32012919174395 1.72107998586749e-25 2.43719213458674e-23 DOWN ENSG00000166233 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:689] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0009893|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0031325|GO:0043169|GO:0019899|GO:0005737|GO:0007154|GO:0007165|GO:0019787|GO:0000151|GO:0019538|GO:0010033|GO:0031323|GO:0032268|GO:0005829|GO:0045732|GO:0046872|GO:0007166|GO:0043412|GO:0034097|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:1990234|GO:0051247|GO:0006508|GO:0032270|GO:0044267|GO:0044390|GO:0042176|GO:0071310|GO:0051246|GO:0044389|GO:0031625|GO:0044257|GO:0019221|GO:0061630|GO:0010498|GO:1903364|GO:0030162|GO:0045862|GO:0051603|GO:0071345|GO:0046914|GO:0031624|GO:0006464|GO:1903052|GO:0019941|GO:1901800|GO:0061136|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0032436|GO:0042787|GO:0016567|GO:0000209 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|positive regulation of metabolic process|ligase activity|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|positive regulation of cellular metabolic process|cation binding|enzyme binding|cytoplasm|cell communication|signal transduction|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|positive regulation of protein catabolic process|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|response to cytokine|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|transferase complex|positive regulation of protein metabolic process|proteolysis|positive regulation of cellular protein metabolic process|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein catabolic process|cellular response to organic substance|regulation of protein metabolic process|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|cytokine-mediated signaling pathway|ubiquitin protein ligase activity|proteasomal protein catabolic process|positive regulation of cellular protein catabolic process|regulation of proteolysis|positive regulation of proteolysis|proteolysis involved in cellular protein catabolic process|cellular response to cytokine stimulus|transition metal ion binding|ubiquitin conjugating enzyme binding|cellular protein modification process|positive regulation of proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|regulation of proteasomal protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 15:72474326-72602985 149 170 331 1437 1512 1382 0.366525171664812 0.380054296614335 0.73410654645658 3.16717344487931 3.05166591278469 3.18606184247885 0.493562004911909 3.13496706671428 -2.66714704417719 1.72254150330877e-25 2.43719213458674e-23 DOWN ENSG00000065883 CDK13 cyclin-dependent kinase 13 [Source:HGNC Symbol;Acc:HGNC:1733] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005615|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:0016032|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0051302|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0046483|GO:0051128|GO:0043231|GO:0005737|GO:0030332|GO:0006139|GO:0000307|GO:0000166|GO:0051301|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0006996|GO:0019908|GO:0010468|GO:0034645|GO:0003723|GO:0035639|GO:1903047|GO:0043412|GO:0030097|GO:0002945|GO:0051252|GO:0001883|GO:0036211|GO:0000278|GO:0032549|GO:0031981|GO:0007346|GO:1990234|GO:0010564|GO:0005654|GO:0016301|GO:0006796|GO:0033043|GO:0044267|GO:0007067|GO:0010467|GO:0017076|GO:0009059|GO:0016070|GO:0016773|GO:0005634|GO:0006396|GO:0007088|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0016310|GO:0016604|GO:0016071|GO:0004672|GO:0044822|GO:0006464|GO:0006351|GO:0006355|GO:0016607|GO:0006366|GO:0006357|GO:1902911|GO:0006468|GO:1903506|GO:0006397|GO:0004674|GO:0097472|GO:0008380|GO:0070816|GO:0000375|GO:0004693|GO:1902554|GO:0008353|GO:0000398|GO:0000380 developmental process|macromolecular complex|immune system process|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|extracellular space|intracellular|immune system development|protein binding|protein complex|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|viral process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|regulation of cell division|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|cyclin binding|nucleobase-containing compound metabolic process|cyclin-dependent protein kinase holoenzyme complex|nucleotide binding|cell division|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|nuclear cyclin-dependent protein kinase holoenzyme complex|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|hemopoiesis|cyclin K-CDK13 complex|regulation of RNA metabolic process|purine nucleoside binding|protein modification process|mitotic cell cycle|ribonucleoside binding|nuclear lumen|regulation of mitotic cell cycle|transferase complex|regulation of cell cycle process|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|mitotic nuclear division|gene expression|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|RNA processing|regulation of mitotic nuclear division|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|nuclear body|mRNA metabolic process|protein kinase activity|poly(A) RNA binding|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|protein kinase complex|protein phosphorylation|regulation of nucleic acid-templated transcription|mRNA processing|protein serine/threonine kinase activity|cyclin-dependent protein kinase activity|RNA splicing|phosphorylation of RNA polymerase II C-terminal domain|RNA splicing, via transesterification reactions|cyclin-dependent protein serine/threonine kinase activity|serine/threonine protein kinase complex|RNA polymerase II carboxy-terminal domain kinase activity|mRNA splicing, via spliceosome|alternative mRNA splicing, via spliceosome - - - - 7:39950037-40097134 178 221 258 1071 1169 1005 0.772938646612244 0.872162319467908 1.01008820902576 4.16688870137461 4.16492448657125 4.08996719446928 0.885063058368637 4.14059346080505 -2.22598540826003 1.86810100020259e-25 2.63067392736076e-23 DOWN ENSG00000116717 GADD45A growth arrest and DNA damage inducible alpha [Source:HGNC Symbol;Acc:HGNC:4095] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0009314|GO:0022402|GO:0009612|GO:1901360|GO:0010941|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0045786|GO:0043231|GO:0005737|GO:0072593|GO:0009966|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0044092|GO:0007165|GO:0008219|GO:0050790|GO:0043086|GO:0009967|GO:0007017|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0006996|GO:0000165|GO:0031023|GO:1902533|GO:0032268|GO:0003677|GO:1903047|GO:0043412|GO:0007010|GO:0044770|GO:0007098|GO:0007050|GO:0051347|GO:0036211|GO:0032269|GO:2000377|GO:0000278|GO:0031981|GO:0031098|GO:0071478|GO:0051247|GO:0005654|GO:0006259|GO:0032270|GO:0012501|GO:0006796|GO:0010212|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:0071260|GO:0043068|GO:1902531|GO:0000226|GO:0005634|GO:0043067|GO:0006974|GO:2000379|GO:0070304|GO:0000975|GO:0031401|GO:0043065|GO:0071850|GO:0043408|GO:0042770|GO:0000086|GO:0044772|GO:0016310|GO:0043410|GO:0051297|GO:0032872|GO:0042981|GO:0033673|GO:0071479|GO:0006464|GO:0051403|GO:0000079|GO:0043549|GO:0006915|GO:0033674|GO:0045859|GO:0045860|GO:1900744|GO:0006469|GO:0046328|GO:0038066|GO:0006468|GO:0044212|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0042326|GO:0000185|GO:0032874|GO:0001934|GO:0001933|GO:0042327|GO:0046330|GO:0001047|GO:1900745|GO:0071902|GO:0071900|GO:0032147 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|response to radiation|cell cycle process|response to mechanical stimulus|organic cyclic compound metabolic process|regulation of cell death|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|reactive oxygen species metabolic process|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|negative regulation of molecular function|signal transduction|cell death|regulation of catalytic activity|negative regulation of catalytic activity|positive regulation of signal transduction|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|MAPK cascade|microtubule organizing center organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|DNA binding|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|cell cycle phase transition|centrosome cycle|cell cycle arrest|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of reactive oxygen species metabolic process|mitotic cell cycle|nuclear lumen|stress-activated protein kinase signaling cascade|cellular response to radiation|positive regulation of protein metabolic process|nucleoplasm|DNA metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|response to ionizing radiation|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|cellular response to mechanical stimulus|positive regulation of programmed cell death|regulation of intracellular signal transduction|microtubule cytoskeleton organization|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|positive regulation of reactive oxygen species metabolic process|positive regulation of stress-activated protein kinase signaling cascade|regulatory region DNA binding|positive regulation of protein modification process|positive regulation of apoptotic process|mitotic cell cycle arrest|regulation of MAPK cascade|signal transduction in response to DNA damage|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|phosphorylation|positive regulation of MAPK cascade|centrosome organization|regulation of stress-activated MAPK cascade|regulation of apoptotic process|negative regulation of kinase activity|cellular response to ionizing radiation|cellular protein modification process|stress-activated MAPK cascade|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of p38MAPK cascade|negative regulation of protein kinase activity|regulation of JNK cascade|p38MAPK cascade|protein phosphorylation|transcription regulatory region DNA binding|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|activation of MAPKKK activity|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of JNK cascade|core promoter binding|positive regulation of p38MAPK cascade|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity K04402 growth arrest and DNA-damage-inducible protein[-] hsa04010|hsa04210|hsa04068|hsa04110|hsa04115 MAPK signaling pathway - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 1:67685061-67688338 1271 1291 1541 346 384 338 22.5612461925653 20.8268502529617 24.6623358382225 5.5028872229411 5.59263017527438 5.62293666441274 22.6834774279165 5.57281802087607 2.02516287720259 1.96212050254543e-25 2.750100726901e-23 UP ENSG00000080503 SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 [Source:HGNC Symbol;Acc:HGNC:11098] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0000988|GO:0003824|GO:0036094|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0000989|GO:0045926|GO:0000785|GO:0016043|GO:0043227|GO:0040008|GO:0009893|GO:0032504|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0042127|GO:0003712|GO:0006725|GO:0042393|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0031325|GO:0046483|GO:0051128|GO:0016817|GO:0070603|GO:0043231|GO:0030308|GO:0001076|GO:0048515|GO:0009890|GO:0003682|GO:0006139|GO:0000790|GO:0007276|GO:0008285|GO:0000166|GO:0071565|GO:0048869|GO:0044249|GO:0001558|GO:0031324|GO:0007281|GO:0031323|GO:0006996|GO:0003713|GO:0051276|GO:0003677|GO:0010468|GO:0007286|GO:0034645|GO:0048232|GO:0035639|GO:0001104|GO:0010629|GO:0051252|GO:0006325|GO:0001883|GO:0010628|GO:0016818|GO:0032549|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0010467|GO:0007399|GO:0017076|GO:0090544|GO:0031328|GO:0009059|GO:0030154|GO:0001191|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0007283|GO:0000975|GO:0045893|GO:0045892|GO:0071564|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:1902679|GO:0001105|GO:0045111|GO:0016568|GO:0016514|GO:0016462|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0017111|GO:0001190|GO:0006338|GO:0000122|GO:0016887|GO:0004386|GO:0042623|GO:0008094 developmental process|growth|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|binding|transcription factor activity, protein binding|catalytic activity|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|transcription factor activity, transcription factor binding|negative regulation of growth|chromatin|cellular component organization|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|regulation of cell proliferation|transcription cofactor activity|cellular aromatic compound metabolic process|histone binding|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|negative regulation of cell growth|transcription factor activity, RNA polymerase II transcription factor binding|spermatid differentiation|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|nuclear chromatin|gamete generation|negative regulation of cell proliferation|nucleotide binding|nBAF complex|cellular developmental process|cellular biosynthetic process|regulation of cell growth|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|chromosome organization|DNA binding|regulation of gene expression|spermatid development|cellular macromolecule biosynthetic process|male gamete generation|purine ribonucleoside triphosphate binding|RNA polymerase II transcription cofactor activity|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|positive regulation of gene expression|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|gene expression|nervous system development|purine nucleotide binding|BAF-type complex|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|spermatogenesis|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|npBAF complex|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|negative regulation of RNA biosynthetic process|RNA polymerase II transcription coactivator activity|intermediate filament cytoskeleton|chromatin modification|SWI/SNF complex|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|nucleoside-triphosphatase activity|transcriptional activator activity, RNA polymerase II transcription factor binding|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|ATPase activity|helicase activity|ATPase activity, coupled|DNA-dependent ATPase activity - - - - 9:2015219-2193624 34 29 37 281 301 277 0.111609525367089 0.0865173411736454 0.109506452721775 0.826461110005389 0.810686144485998 0.852173118121081 0.10254443975417 0.829773457537489 -3.01646824260853 1.99956293734245e-25 2.78948373511316e-23 DOWN ENSG00000176463 SLCO3A1 solute carrier organic anion transporter family member 3A1 [Source:HGNC Symbol;Acc:HGNC:10952] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0022857|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0010876|GO:0006811|GO:0015075|GO:0006869|GO:0015347|GO:0006820|GO:0015711|GO:0008509|GO:0015908|GO:0046942|GO:0015732|GO:0015718|GO:0043252|GO:0008514 transporter activity|cell|membrane|cellular process|binding|transmembrane transporter activity|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|lipid localization|ion transport|ion transmembrane transporter activity|lipid transport|sodium-independent organic anion transmembrane transporter activity|anion transport|organic anion transport|anion transmembrane transporter activity|fatty acid transport|carboxylic acid transport|prostaglandin transport|monocarboxylic acid transport|sodium-independent organic anion transport|organic anion transmembrane transporter activity - - - - 15:91853695-92172435 35 34 73 409 520 648 0.173495031156911 0.153172268443473 0.326257720618744 1.81653140296656 2.11491654952363 3.01040800825451 0.217641673406376 2.3139519869149 -3.41033219843863 2.05694147211791e-25 2.85618282365619e-23 DOWN ENSG00000170684 ZNF296 zinc finger protein 296 [Source:HGNC Symbol;Acc:HGNC:15981] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0000989|GO:0043227|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0048609|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0001076|GO:0009890|GO:0006139|GO:0007276|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0048232|GO:0046872|GO:0010629|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0007283|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 reproduction|cell|cellular process|reproductive process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|multicellular organismal reproductive process|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|transcription factor activity, RNA polymerase II transcription factor binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|gamete generation|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gamete generation|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|spermatogenesis|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 19:45071500-45076588 367 333 290 38 51 35 8.04974990062982 6.63804713705055 5.73493576451806 0.746793265379124 0.917812693682308 0.719467645029997 6.80757760073281 0.79469120136381 3.09867524644277 2.24852885879456e-25 3.10775835881727e-23 UP ENSG00000111110 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H [Source:HGNC Symbol;Acc:HGNC:18583] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0016788|GO:0043231|GO:0005737|GO:0019538|GO:0043412|GO:0036211|GO:0006796|GO:0044267|GO:0005634|GO:0042578|GO:0016311|GO:0016791|GO:0006464|GO:0006470|GO:0004721|GO:0004722 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|hydrolase activity, acting on ester bonds|intracellular membrane-bounded organelle|cytoplasm|protein metabolic process|macromolecule modification|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|nucleus|phosphoric ester hydrolase activity|dephosphorylation|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|protein serine/threonine phosphatase activity - - - - 12:62643982-62935037 30 39 65 378 445 367 0.273957287554073 0.323681281402218 0.535175994998163 3.09283872303472 3.33423405319412 3.14096317762585 0.377604854651485 3.18934531795156 -3.07831109220349 2.36545977201474e-25 3.2543058080059e-23 DOWN ENSG00000115159 GPD2 glycerol-3-phosphate dehydrogenase 2 [Source:HGNC Symbol;Acc:HGNC:4456] GO:0032502|GO:0040007|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0048589|GO:0005622|GO:0043234|GO:0048856|GO:0031090|GO:0044262|GO:0044255|GO:0019866|GO:0007275|GO:0048513|GO:0044281|GO:0019637|GO:0016614|GO:0043231|GO:0043169|GO:0005737|GO:0007423|GO:0005975|GO:0035264|GO:0031966|GO:0009331|GO:0006629|GO:0055114|GO:0005740|GO:0046872|GO:0001654|GO:0006066|GO:0044275|GO:0006071|GO:0005743|GO:0005996|GO:0005739|GO:0016052|GO:0006796|GO:0016901|GO:0016051|GO:0019563|GO:0019318|GO:0043010|GO:0004368|GO:0046164|GO:0005509|GO:0006072|GO:0019319|GO:0006006|GO:0006094|GO:0052591 developmental process|growth|macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|developmental growth|intracellular|protein complex|anatomical structure development|organelle membrane|cellular carbohydrate metabolic process|cellular lipid metabolic process|organelle inner membrane|multicellular organism development|animal organ development|small molecule metabolic process|organophosphate metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cation binding|cytoplasm|sensory organ development|carbohydrate metabolic process|multicellular organism growth|mitochondrial membrane|glycerol-3-phosphate dehydrogenase complex|lipid metabolic process|oxidation-reduction process|mitochondrial envelope|metal ion binding|eye development|alcohol metabolic process|cellular carbohydrate catabolic process|glycerol metabolic process|mitochondrial inner membrane|monosaccharide metabolic process|mitochondrion|carbohydrate catabolic process|phosphate-containing compound metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|carbohydrate biosynthetic process|glycerol catabolic process|hexose metabolic process|camera-type eye development|glycerol-3-phosphate dehydrogenase activity|alcohol catabolic process|calcium ion binding|glycerol-3-phosphate metabolic process|hexose biosynthetic process|glucose metabolic process|gluconeogenesis|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity K00111 glycerol-3-phosphate dehydrogenase[1.1.5.3] hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) 2:156435290-156613735 97 204 260 1411 1476 1302 0.639166630669963 1.22166833946252 1.54465701248468 8.33044596303415 7.97991231826573 8.04051234851894 1.13516399420572 8.11695687660627 -2.83803821385706 2.72259172148343e-25 3.7284519840902e-23 DOWN ENSG00000131725 WDR44 WD repeat domain 44 [Source:HGNC Symbol;Acc:HGNC:30512] GO:0040011|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0040012|GO:0043229|GO:0048870|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0005874|GO:0043231|GO:0019899|GO:0005737|GO:0006928|GO:0051270|GO:0016477|GO:0010008|GO:2000145|GO:0005794|GO:0005768|GO:0005829|GO:0030334|GO:0048471|GO:0051020|GO:0005856|GO:0015630|GO:0031267|GO:0017016|GO:0017137 locomotion|cell|membrane|cellular process|binding|regulation of cellular process|regulation of locomotion|intracellular organelle|cell motility|membrane-bounded organelle|intracellular|protein binding|endomembrane system|organelle membrane|microtubule|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|movement of cell or subcellular component|regulation of cellular component movement|cell migration|endosome membrane|regulation of cell motility|Golgi apparatus|endosome|cytosol|regulation of cell migration|perinuclear region of cytoplasm|GTPase binding|cytoskeleton|microtubule cytoskeleton|small GTPase binding|Ras GTPase binding|Rab GTPase binding - - - - X:118346073-118449961 122 144 236 932 1082 1006 0.931853174103177 0.999608195592917 1.62522619383457 6.37824932134721 6.78083031814248 7.20136608824989 1.18556252117689 6.78681524257986 -2.51716299318006 2.73993694509937e-25 3.73507203465738e-23 DOWN ENSG00000138696 BMPR1B bone morphogenetic protein receptor type IB [Source:HGNC Symbol;Acc:HGNC:1077] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0001550|GO:0006807|GO:0006950|GO:0001502|GO:0005057|GO:0044702|GO:0071704|GO:0043167|GO:0042698|GO:0019953|GO:0044237|GO:0038023|GO:0003006|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0050793|GO:0048589|GO:0022602|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0042127|GO:0035988|GO:0022605|GO:0006935|GO:0045595|GO:0006725|GO:0060041|GO:0009888|GO:0048468|GO:0043025|GO:1901360|GO:0010941|GO:0098797|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0006952|GO:0061036|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0001547|GO:0010942|GO:0070169|GO:0005887|GO:0045597|GO:0048608|GO:0046332|GO:0001541|GO:0043169|GO:0004888|GO:0007389|GO:0007423|GO:0043235|GO:0006928|GO:0009887|GO:0043005|GO:0009966|GO:0007548|GO:0036477|GO:0010646|GO:0006139|GO:0031226|GO:0008406|GO:1990712|GO:0007154|GO:0045778|GO:0007276|GO:0007165|GO:0030278|GO:0001503|GO:0004702|GO:0008219|GO:0060348|GO:0008285|GO:0000166|GO:0030030|GO:0001948|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0007281|GO:0031323|GO:0030501|GO:2001235|GO:0000902|GO:0031175|GO:1902731|GO:0048705|GO:0010468|GO:0071773|GO:0034645|GO:0051216|GO:0046872|GO:0007166|GO:0001654|GO:0035639|GO:0043412|GO:0008585|GO:0061458|GO:0051252|GO:0002063|GO:0001883|GO:0045667|GO:0031214|GO:0000904|GO:0048477|GO:0046545|GO:0010628|GO:0009100|GO:0036211|GO:0006954|GO:0032549|GO:0001649|GO:0003002|GO:0030425|GO:0070848|GO:0016301|GO:0045669|GO:0012501|GO:0006796|GO:1901137|GO:0035108|GO:0044267|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0060349|GO:0097485|GO:0017076|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0060173|GO:0061035|GO:0043068|GO:0016070|GO:0016773|GO:0007292|GO:0010557|GO:0030282|GO:0043067|GO:0097190|GO:0030500|GO:0048666|GO:0030182|GO:0007411|GO:0009101|GO:0045893|GO:0043065|GO:0060350|GO:0043010|GO:0002062|GO:0032774|GO:0005524|GO:2001141|GO:2001236|GO:0071363|GO:0030554|GO:0016310|GO:2001238|GO:0004675|GO:0061564|GO:0030509|GO:0007167|GO:0009953|GO:0042981|GO:0006029|GO:0004672|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0097191|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0007409|GO:1902043|GO:0006468|GO:0048699|GO:1903506|GO:0004674|GO:0005024|GO:0007178|GO:0030166|GO:0031290|GO:0008625|GO:1902041|GO:0005025 locomotion|developmental process|growth|macromolecular complex|signal transducer activity|reproduction|signaling|cell|rhythmic process|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|ovarian cumulus expansion|nitrogen compound metabolic process|response to stress|cartilage condensation|receptor signaling protein activity|single organism reproductive process|organic substance metabolic process|ion binding|ovulation cycle|sexual reproduction|cellular metabolic process|signaling receptor activity|developmental process involved in reproduction|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|regulation of developmental process|developmental growth|ovulation cycle process|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|regulation of cell proliferation|chondrocyte proliferation|oogenesis stage|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|retina development in camera-type eye|tissue development|cell development|neuronal cell body|organic cyclic compound metabolic process|regulation of cell death|plasma membrane protein complex|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|defense response|positive regulation of cartilage development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|antral ovarian follicle growth|positive regulation of cell death|positive regulation of biomineral tissue development|integral component of plasma membrane|positive regulation of cell differentiation|reproductive structure development|SMAD binding|ovarian follicle development|cation binding|transmembrane signaling receptor activity|pattern specification process|sensory organ development|receptor complex|movement of cell or subcellular component|organ morphogenesis|neuron projection|regulation of signal transduction|sex differentiation|somatodendritic compartment|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|gonad development|HFE-transferrin receptor complex|cell communication|positive regulation of ossification|gamete generation|signal transduction|regulation of ossification|ossification|receptor signaling protein serine/threonine kinase activity|cell death|bone development|negative regulation of cell proliferation|nucleotide binding|cell projection organization|glycoprotein binding|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|germ cell development|regulation of cellular metabolic process|positive regulation of bone mineralization|positive regulation of apoptotic signaling pathway|cell morphogenesis|neuron projection development|negative regulation of chondrocyte proliferation|skeletal system morphogenesis|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|cartilage development|metal ion binding|cell surface receptor signaling pathway|eye development|purine ribonucleoside triphosphate binding|macromolecule modification|female gonad development|reproductive system development|regulation of RNA metabolic process|chondrocyte development|purine nucleoside binding|regulation of osteoblast differentiation|biomineral tissue development|cell morphogenesis involved in differentiation|oogenesis|development of primary female sexual characteristics|positive regulation of gene expression|glycoprotein metabolic process|protein modification process|inflammatory response|ribonucleoside binding|osteoblast differentiation|regionalization|dendrite|response to growth factor|kinase activity|positive regulation of osteoblast differentiation|programmed cell death|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|limb morphogenesis|cellular protein metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|bone morphogenesis|neuron projection guidance|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|limb development|regulation of cartilage development|positive regulation of programmed cell death|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|female gamete generation|positive regulation of macromolecule biosynthetic process|bone mineralization|regulation of programmed cell death|apoptotic signaling pathway|regulation of bone mineralization|neuron development|neuron differentiation|axon guidance|glycoprotein biosynthetic process|positive regulation of transcription, DNA-templated|positive regulation of apoptotic process|endochondral bone morphogenesis|camera-type eye development|chondrocyte differentiation|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|regulation of extrinsic apoptotic signaling pathway|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|positive regulation of extrinsic apoptotic signaling pathway|transmembrane receptor protein serine/threonine kinase activity|axon development|BMP signaling pathway|enzyme linked receptor protein signaling pathway|dorsal/ventral pattern formation|regulation of apoptotic process|proteoglycan metabolic process|protein kinase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|axonogenesis|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transmembrane receptor protein serine/threonine kinase signaling pathway|proteoglycan biosynthetic process|retinal ganglion cell axon guidance|extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway via death domain receptors|transforming growth factor beta receptor activity, type I K13578 bone morphogenetic protein receptor type-1B[2.7.11.30] hsa04060|hsa04360|hsa04390|hsa04550|hsa04350 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human) 4:94757968-95158448 5 5 20 200 199 181 0.0302437747084458 0.0274875532324256 0.109068921755816 1.08385820383776 0.987565955816834 1.02601118128477 0.0556000832322291 1.03247844697979 -4.21488081279275 2.92866082424435e-25 3.97419273849959e-23 DOWN ENSG00000204516 MICB MHC class I polypeptide-related sequence B [Source:HGNC Symbol;Acc:HGNC:7091] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0019835|GO:0051716|GO:0002683|GO:0050794|GO:0045321|GO:0001909|GO:0019882|GO:0006950|GO:0006955|GO:0009628|GO:0003823|GO:0009986|GO:0051707|GO:0007155|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0002684|GO:0042267|GO:0002682|GO:0001913|GO:0005515|GO:0005886|GO:0016032|GO:0002757|GO:0002250|GO:0016337|GO:0045087|GO:0050688|GO:0070489|GO:0005102|GO:0006952|GO:0098542|GO:0098609|GO:0009408|GO:0009615|GO:0001775|GO:0006979|GO:0050776|GO:0046649|GO:0007154|GO:0007165|GO:0050778|GO:0050687|GO:0051607|GO:0016021|GO:0009266|GO:0010033|GO:0002443|GO:0050689|GO:0007166|GO:0033993|GO:0002228|GO:0002429|GO:0007159|GO:0046703|GO:0002764|GO:0002460|GO:0042110|GO:0032526|GO:0050691|GO:0002456|GO:0002768|GO:0070486|GO:0046629|GO:0071593 immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cytolysis|cellular response to stimulus|negative regulation of immune system process|regulation of cellular process|leukocyte activation|leukocyte mediated cytotoxicity|antigen processing and presentation|response to stress|immune response|response to abiotic stimulus|antigen binding|cell surface|response to other organism|cell adhesion|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|positive regulation of immune system process|natural killer cell mediated cytotoxicity|regulation of immune system process|T cell mediated cytotoxicity|protein binding|plasma membrane|viral process|immune response-activating signal transduction|adaptive immune response|single organismal cell-cell adhesion|innate immune response|regulation of defense response to virus|T cell aggregation|receptor binding|defense response|defense response to other organism|cell-cell adhesion|response to heat|response to virus|cell activation|response to oxidative stress|regulation of immune response|lymphocyte activation|cell communication|signal transduction|positive regulation of immune response|negative regulation of defense response to virus|defense response to virus|integral component of membrane|response to temperature stimulus|response to organic substance|leukocyte mediated immunity|negative regulation of defense response to virus by host|cell surface receptor signaling pathway|response to lipid|natural killer cell mediated immunity|immune response-activating cell surface receptor signaling pathway|leukocyte cell-cell adhesion|natural killer cell lectin-like receptor binding|immune response-regulating signaling pathway|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|T cell activation|response to retinoic acid|regulation of defense response to virus by host|T cell mediated immunity|immune response-regulating cell surface receptor signaling pathway|leukocyte aggregation|gamma-delta T cell activation|lymphocyte aggregation K07985 MHC class I-related protein[-] hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) 6:31494881-31511124 1552 1664 1781 436 478 413 23.1806570499614 22.5874561567152 23.9834755710316 5.83468960375829 5.85773855309126 5.78113770307586 23.2505295925694 5.82452195330847 1.99705202702879 2.97087125554135e-25 4.0132303376892e-23 UP ENSG00000136560 TANK TRAF family member associated NFKB activator [Source:HGNC Symbol;Acc:HGNC:11562] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0043167|GO:0006955|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0002757|GO:0045087|GO:0006952|GO:0043169|GO:0019899|GO:0005737|GO:0002218|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0005829|GO:0046872|GO:0002758|GO:0002764|GO:0035556|GO:0045089|GO:0045088|GO:0044389|GO:0031625|GO:0002221|GO:0007249|GO:0002224|GO:0002756|GO:0034138|GO:0034142|GO:0035666 immune system process|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|ion binding|immune response|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|immune response-activating signal transduction|innate immune response|defense response|cation binding|enzyme binding|cytoplasm|activation of innate immune response|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|cytosol|metal ion binding|innate immune response-activating signal transduction|immune response-regulating signaling pathway|intracellular signal transduction|positive regulation of innate immune response|regulation of innate immune response|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|pattern recognition receptor signaling pathway|I-kappaB kinase/NF-kappaB signaling|toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway K12650 TRAF family member-associated NF-kappa-B activator[-] hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) 2:161136908-161236221 59 73 126 605 650 703 0.349505557852272 0.393015951463859 0.672961586678225 3.21112983868923 3.15926839897226 3.90291699948239 0.471827698664785 3.42443841238129 -2.85953539437973 4.2282972344206e-25 5.68610746109877e-23 DOWN ENSG00000147044 CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) [Source:HGNC Symbol;Acc:HGNC:1497] GO:0031012|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0005604|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0030055|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0005578|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0016740|GO:0097060|GO:0005929|GO:0031090|GO:0019222|GO:0042127|GO:0006725|GO:0016323|GO:0006810|GO:1901360|GO:0005102|GO:0034641|GO:0043168|GO:0005924|GO:0043062|GO:0060170|GO:0044281|GO:0032940|GO:0030155|GO:0005912|GO:0001882|GO:0043270|GO:0016772|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0090287|GO:0043231|GO:0005737|GO:0007267|GO:0042734|GO:0009611|GO:0031589|GO:0050673|GO:0090288|GO:0006139|GO:0007162|GO:0055086|GO:0005516|GO:0007154|GO:0055085|GO:0051649|GO:0001505|GO:0008285|GO:0000166|GO:0031253|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0006836|GO:0005730|GO:0005829|GO:0010468|GO:0034645|GO:0035639|GO:0043412|GO:0019693|GO:0051252|GO:0001883|GO:0010628|GO:0034767|GO:0010812|GO:0036211|GO:0009116|GO:0007160|GO:0042060|GO:0006811|GO:0032549|GO:0042043|GO:0031981|GO:0010810|GO:0070848|GO:0034765|GO:0016363|GO:0050678|GO:0016301|GO:0050680|GO:0043269|GO:0061045|GO:0006796|GO:0044267|GO:0010467|GO:0046903|GO:0071310|GO:0017076|GO:0030198|GO:0031328|GO:0009059|GO:0034399|GO:0016070|GO:0051928|GO:0043616|GO:0016773|GO:0005856|GO:0010557|GO:0005634|GO:0016776|GO:0005652|GO:0005925|GO:0034220|GO:0015629|GO:0010837|GO:0045893|GO:0009259|GO:0009117|GO:0032774|GO:0005524|GO:0090280|GO:0006812|GO:2001141|GO:0001953|GO:0071363|GO:0030554|GO:0016310|GO:0019205|GO:0004385|GO:0001952|GO:0009132|GO:0006163|GO:0004672|GO:0006464|GO:0042278|GO:0006351|GO:0006355|GO:0090279|GO:0010839|GO:0061041|GO:0045944|GO:0006366|GO:0006357|GO:0006468|GO:1903506|GO:0004674|GO:0019201|GO:0030001|GO:0051924|GO:0007268|GO:0046037|GO:0046710|GO:0006816|GO:0070509 extracellular matrix|synapse|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|basement membrane|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|cell-substrate junction|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|neurotransmitter secretion|protein binding|plasma membrane|transferase activity|synaptic membrane|cilium|organelle membrane|regulation of metabolic process|regulation of cell proliferation|cellular aromatic compound metabolic process|basolateral plasma membrane|transport|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|anion binding|cell-substrate adherens junction|extracellular structure organization|ciliary membrane|small molecule metabolic process|secretion by cell|regulation of cell adhesion|adherens junction|nucleoside binding|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|presynaptic membrane|response to wounding|cell-substrate adhesion|epithelial cell proliferation|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|negative regulation of cell adhesion|nucleobase-containing small molecule metabolic process|calmodulin binding|cell communication|transmembrane transport|establishment of localization in cell|regulation of neurotransmitter levels|negative regulation of cell proliferation|nucleotide binding|cell projection membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|neurotransmitter transport|nucleolus|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|macromolecule modification|ribose phosphate metabolic process|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of gene expression|positive regulation of ion transmembrane transport|negative regulation of cell-substrate adhesion|protein modification process|nucleoside metabolic process|cell-matrix adhesion|wound healing|ion transport|ribonucleoside binding|neurexin family protein binding|nuclear lumen|regulation of cell-substrate adhesion|response to growth factor|regulation of ion transmembrane transport|nuclear matrix|regulation of epithelial cell proliferation|kinase activity|negative regulation of epithelial cell proliferation|regulation of ion transport|negative regulation of wound healing|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|secretion|cellular response to organic substance|purine nucleotide binding|extracellular matrix organization|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|nuclear periphery|RNA metabolic process|positive regulation of calcium ion transport|keratinocyte proliferation|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|phosphotransferase activity, phosphate group as acceptor|nuclear lamina|focal adhesion|ion transmembrane transport|actin cytoskeleton|regulation of keratinocyte proliferation|positive regulation of transcription, DNA-templated|ribonucleotide metabolic process|nucleotide metabolic process|RNA biosynthetic process|ATP binding|positive regulation of calcium ion import|cation transport|regulation of RNA biosynthetic process|negative regulation of cell-matrix adhesion|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|nucleobase-containing compound kinase activity|guanylate kinase activity|regulation of cell-matrix adhesion|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|protein kinase activity|cellular protein modification process|purine nucleoside metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of calcium ion import|negative regulation of keratinocyte proliferation|regulation of wound healing|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|protein serine/threonine kinase activity|nucleotide kinase activity|metal ion transport|regulation of calcium ion transport|synaptic transmission|GMP metabolic process|GDP metabolic process|calcium ion transport|calcium ion import K06103 calcium/calmodulin-dependent serine protein kinase[2.7.11.1] hsa04530 Tight junction - Homo sapiens (human) X:41514934-41923463 152 183 274 1073 1093 1235 0.625809420622331 0.684745166470379 1.01709557119046 3.9581734852806 3.69220258392117 4.76533327437521 0.77588338609439 4.13856978119233 -2.41522054386986 4.98930923222607e-25 6.67940976766264e-23 DOWN ENSG00000100030 MAPK1 mitogen-activated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:6871] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0030055|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0005057|GO:0044702|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0003006|GO:0048870|GO:0023051|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0016032|GO:0007507|GO:0051219|GO:0031143|GO:0060341|GO:0008284|GO:0051272|GO:0002757|GO:0042127|GO:0007049|GO:0050817|GO:0060674|GO:0001890|GO:0050804|GO:0006935|GO:0045087|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0043025|GO:0006810|GO:0070849|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0044853|GO:0007275|GO:0030324|GO:0060627|GO:0003676|GO:0045596|GO:0048513|GO:0050877|GO:0034641|GO:0043168|GO:0005924|GO:0032204|GO:0044281|GO:0006952|GO:0005912|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0032839|GO:0050806|GO:0032206|GO:0050803|GO:0043231|GO:0000723|GO:0048608|GO:0019899|GO:0010243|GO:0005737|GO:0002218|GO:0007267|GO:0009611|GO:0060322|GO:0007423|GO:0009408|GO:0006928|GO:0009887|GO:0042592|GO:0001775|GO:0043005|GO:0009966|GO:0048598|GO:0043204|GO:0048568|GO:0050673|GO:0045184|GO:0036477|GO:0030323|GO:0010646|GO:0006139|GO:0001892|GO:0043085|GO:0032838|GO:0009617|GO:0050776|GO:0055086|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0070062|GO:0031647|GO:0060438|GO:0051649|GO:0008134|GO:0004702|GO:0009725|GO:0008219|GO:0048645|GO:0050790|GO:0000166|GO:0030030|GO:0060324|GO:0048869|GO:2000145|GO:0009967|GO:0044249|GO:0009266|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031323|GO:0010256|GO:0048732|GO:0050878|GO:0060711|GO:0005794|GO:0005768|GO:0006996|GO:0051090|GO:0009636|GO:0071774|GO:1900034|GO:0000165|GO:0016192|GO:0060425|GO:0051276|GO:1902533|GO:0005901|GO:0032268|GO:0000902|GO:0006909|GO:0005829|GO:0031175|GO:0003677|GO:0007004|GO:0030879|GO:0048538|GO:0010468|GO:0034645|GO:0030168|GO:0006518|GO:0048167|GO:0007166|GO:0010833|GO:0033993|GO:0035639|GO:0030424|GO:0001944|GO:0043412|GO:0072594|GO:0007010|GO:0007030|GO:0061458|GO:0002758|GO:0072358|GO:0034097|GO:0007417|GO:0043583|GO:0002237|GO:0005769|GO:0007596|GO:0051252|GO:0060541|GO:0005815|GO:0035051|GO:0032386|GO:0001883|GO:0015031|GO:1901652|GO:0061308|GO:0000904|GO:0009790|GO:0071417|GO:0010628|GO:0030334|GO:0030878|GO:0051347|GO:0036211|GO:0043331|GO:0042060|GO:0071219|GO:0046907|GO:1904358|GO:0032549|GO:2000641|GO:0019902|GO:0002429|GO:0060440|GO:0007600|GO:0005770|GO:0060485|GO:0035270|GO:0004707|GO:0031981|GO:0031098|GO:0043434|GO:0007599|GO:0030425|GO:0044344|GO:0034605|GO:0051247|GO:0070848|GO:0005654|GO:0006259|GO:0005739|GO:0002764|GO:0016301|GO:0034613|GO:0019900|GO:0032270|GO:0012501|GO:0060291|GO:0014070|GO:0060429|GO:0051054|GO:0006796|GO:0043603|GO:0035556|GO:0033043|GO:0045309|GO:0044267|GO:0051174|GO:0048864|GO:0010467|GO:0017038|GO:0032990|GO:0048562|GO:0007399|GO:0071310|GO:0060439|GO:0097485|GO:0017076|GO:0031328|GO:1904355|GO:0051246|GO:1904356|GO:0009059|GO:0030154|GO:0048858|GO:0045121|GO:0042473|GO:0030335|GO:0016233|GO:1902531|GO:0016070|GO:0060716|GO:0072359|GO:0016773|GO:0032870|GO:0005856|GO:0010557|GO:0032496|GO:0005634|GO:0033598|GO:0005819|GO:0038096|GO:0045089|GO:0048545|GO:0006974|GO:0006606|GO:0005925|GO:0045088|GO:0010638|GO:0048666|GO:2001252|GO:0030182|GO:0007411|GO:0045893|GO:0048863|GO:0043043|GO:0033365|GO:0009792|GO:0031401|GO:0032200|GO:0006260|GO:0072686|GO:0008543|GO:0010001|GO:0019233|GO:0051169|GO:1901653|GO:0043408|GO:0001784|GO:0051972|GO:0032774|GO:0000189|GO:0005524|GO:2001141|GO:0045727|GO:0014031|GO:0071363|GO:0051973|GO:0030554|GO:0045022|GO:0016310|GO:0043627|GO:0006605|GO:0033044|GO:0010608|GO:0002768|GO:0006206|GO:0038179|GO:0070371|GO:0002221|GO:1903358|GO:0060416|GO:0032212|GO:0061564|GO:0016482|GO:0006412|GO:0006886|GO:2000278|GO:0042471|GO:0051493|GO:0007167|GO:0015630|GO:0016197|GO:0006417|GO:0071375|GO:0043410|GO:0006275|GO:0032872|GO:0071345|GO:0004672|GO:0032868|GO:0048762|GO:0002431|GO:2000573|GO:0006897|GO:0045740|GO:0019901|GO:0022008|GO:0043330|GO:0048667|GO:0007264|GO:0006464|GO:0061180|GO:0050851|GO:0048812|GO:0071396|GO:0051403|GO:0071897|GO:0032210|GO:0043549|GO:0048708|GO:0006351|GO:0006915|GO:0006355|GO:0071222|GO:0033674|GO:0031663|GO:0014033|GO:0048011|GO:0000186|GO:0014032|GO:0006278|GO:0007259|GO:0007265|GO:0006913|GO:0045859|GO:0045860|GO:0002224|GO:0043406|GO:0019858|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0060020|GO:0043405|GO:0042325|GO:0071378|GO:0001932|GO:0032869|GO:0018193|GO:0097011|GO:0031435|GO:0038093|GO:0006898|GO:0042063|GO:0004674|GO:0043009|GO:0001934|GO:0050852|GO:0050853|GO:0042327|GO:0034504|GO:0007268|GO:0007169|GO:0090170|GO:0048010|GO:0060397|GO:0051170|GO:0038094|GO:0034166|GO:0034134|GO:0038124|GO:0000187|GO:0038095|GO:0002756|GO:0071902|GO:0060396|GO:0072584|GO:0018105|GO:0034138|GO:0002755|GO:0034146|GO:0008353|GO:0071900|GO:0018107|GO:0001701|GO:0034142|GO:0038123|GO:0034162|GO:0032147|GO:0008286|GO:0038127|GO:0010800|GO:0007173|GO:0035666 locomotion|developmental process|macromolecular complex|signal transducer activity|reproduction|immune system process|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|cell-substrate junction|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|receptor signaling protein activity|single organism reproductive process|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|developmental process involved in reproduction|cell motility|regulation of signaling|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|viral process|heart development|phosphoprotein binding|pseudopodium|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|immune response-activating signal transduction|regulation of cell proliferation|cell cycle|coagulation|placenta blood vessel development|placenta development|modulation of synaptic transmission|chemotaxis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|neuronal cell body|transport|response to epidermal growth factor|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|plasma membrane raft|multicellular organism development|lung development|regulation of vesicle-mediated transport|nucleic acid binding|negative regulation of cell differentiation|animal organ development|neurological system process|cellular nitrogen compound metabolic process|anion binding|cell-substrate adherens junction|regulation of telomere maintenance|small molecule metabolic process|defense response|adherens junction|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|dendrite cytoplasm|positive regulation of synaptic transmission|positive regulation of telomere maintenance|regulation of synapse structure or activity|intracellular membrane-bounded organelle|telomere maintenance|reproductive structure development|enzyme binding|response to organonitrogen compound|cytoplasm|activation of innate immune response|cell-cell signaling|response to wounding|head development|sensory organ development|response to heat|movement of cell or subcellular component|organ morphogenesis|homeostatic process|cell activation|neuron projection|regulation of signal transduction|embryonic morphogenesis|perikaryon|embryonic organ development|epithelial cell proliferation|establishment of protein localization|somatodendritic compartment|respiratory tube development|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|positive regulation of catalytic activity|cell projection cytoplasm|response to bacterium|regulation of immune response|nucleobase-containing small molecule metabolic process|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|extracellular exosome|regulation of protein stability|trachea development|establishment of localization in cell|transcription factor binding|receptor signaling protein serine/threonine kinase activity|response to hormone|cell death|organ formation|regulation of catalytic activity|nucleotide binding|cell projection organization|face development|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|regulation of cellular metabolic process|endomembrane system organization|gland development|regulation of body fluid levels|labyrinthine layer development|Golgi apparatus|endosome|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|response to toxic substance|response to fibroblast growth factor|regulation of cellular response to heat|MAPK cascade|vesicle-mediated transport|lung morphogenesis|chromosome organization|positive regulation of intracellular signal transduction|caveola|regulation of cellular protein metabolic process|cell morphogenesis|phagocytosis|cytosol|neuron projection development|DNA binding|telomere maintenance via telomerase|mammary gland development|thymus development|regulation of gene expression|cellular macromolecule biosynthetic process|platelet activation|peptide metabolic process|regulation of synaptic plasticity|cell surface receptor signaling pathway|telomere maintenance via telomere lengthening|response to lipid|purine ribonucleoside triphosphate binding|axon|vasculature development|macromolecule modification|establishment of protein localization to organelle|cytoskeleton organization|Golgi organization|reproductive system development|innate immune response-activating signal transduction|cardiovascular system development|response to cytokine|central nervous system development|ear development|response to molecule of bacterial origin|early endosome|blood coagulation|regulation of RNA metabolic process|respiratory system development|microtubule organizing center|cardiocyte differentiation|regulation of intracellular transport|purine nucleoside binding|protein transport|response to peptide|cardiac neural crest cell development involved in heart development|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|positive regulation of gene expression|regulation of cell migration|thyroid gland development|positive regulation of transferase activity|protein modification process|response to dsRNA|wound healing|cellular response to molecule of bacterial origin|intracellular transport|positive regulation of telomere maintenance via telomere lengthening|ribonucleoside binding|regulation of early endosome to late endosome transport|phosphatase binding|immune response-activating cell surface receptor signaling pathway|trachea formation|sensory perception|late endosome|mesenchyme development|endocrine system development|MAP kinase activity|nuclear lumen|stress-activated protein kinase signaling cascade|response to peptide hormone|hemostasis|dendrite|cellular response to fibroblast growth factor stimulus|cellular response to heat|positive regulation of protein metabolic process|response to growth factor|nucleoplasm|DNA metabolic process|mitochondrion|immune response-regulating signaling pathway|kinase activity|cellular protein localization|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|long-term synaptic potentiation|response to organic cyclic compound|epithelium development|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|regulation of organelle organization|protein phosphorylated amino acid binding|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|gene expression|protein import|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|cellular response to organic substance|trachea morphogenesis|neuron projection guidance|purine nucleotide binding|positive regulation of cellular biosynthetic process|positive regulation of telomere capping|regulation of protein metabolic process|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|membrane raft|outer ear morphogenesis|positive regulation of cell migration|telomere capping|regulation of intracellular signal transduction|RNA metabolic process|labyrinthine layer blood vessel development|circulatory system development|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|mammary gland epithelial cell proliferation|spindle|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of innate immune response|response to steroid hormone|cellular response to DNA damage stimulus|protein import into nucleus|focal adhesion|regulation of innate immune response|positive regulation of organelle organization|neuron development|positive regulation of chromosome organization|neuron differentiation|axon guidance|positive regulation of transcription, DNA-templated|stem cell differentiation|peptide biosynthetic process|protein localization to organelle|embryo development ending in birth or egg hatching|positive regulation of protein modification process|telomere organization|DNA replication|mitotic spindle|fibroblast growth factor receptor signaling pathway|glial cell differentiation|sensory perception of pain|nuclear transport|cellular response to peptide|regulation of MAPK cascade|phosphotyrosine binding|regulation of telomerase activity|RNA biosynthetic process|MAPK import into nucleus|ATP binding|regulation of RNA biosynthetic process|positive regulation of translation|mesenchymal cell development|cellular response to growth factor stimulus|positive regulation of telomerase activity|adenyl nucleotide binding|early endosome to late endosome transport|phosphorylation|response to estrogen|protein targeting|regulation of chromosome organization|posttranscriptional regulation of gene expression|immune response-regulating cell surface receptor signaling pathway|pyrimidine nucleobase metabolic process|neurotrophin signaling pathway|ERK1 and ERK2 cascade|pattern recognition receptor signaling pathway|regulation of Golgi organization|response to growth hormone|positive regulation of telomere maintenance via telomerase|axon development|cytosolic transport|translation|intracellular protein transport|regulation of DNA biosynthetic process|ear morphogenesis|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|endosomal transport|regulation of translation|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of DNA replication|regulation of stress-activated MAPK cascade|cellular response to cytokine stimulus|protein kinase activity|response to insulin|mesenchymal cell differentiation|Fc receptor mediated stimulatory signaling pathway|positive regulation of DNA biosynthetic process|endocytosis|positive regulation of DNA replication|protein kinase binding|neurogenesis|response to exogenous dsRNA|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|mammary gland epithelium development|antigen receptor-mediated signaling pathway|neuron projection morphogenesis|cellular response to lipid|stress-activated MAPK cascade|DNA biosynthetic process|regulation of telomere maintenance via telomerase|regulation of kinase activity|astrocyte differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular response to lipopolysaccharide|positive regulation of kinase activity|lipopolysaccharide-mediated signaling pathway|neural crest cell differentiation|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|neural crest cell development|RNA-dependent DNA replication|JAK-STAT cascade|Ras protein signal transduction|nucleocytoplasmic transport|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|cytosine metabolic process|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|Bergmann glial cell differentiation|regulation of MAP kinase activity|regulation of phosphorylation|cellular response to growth hormone stimulus|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|cellular response to granulocyte macrophage colony-stimulating factor stimulus|mitogen-activated protein kinase kinase kinase binding|Fc receptor signaling pathway|receptor-mediated endocytosis|gliogenesis|protein serine/threonine kinase activity|chordate embryonic development|positive regulation of protein phosphorylation|T cell receptor signaling pathway|B cell receptor signaling pathway|positive regulation of phosphorylation|protein localization to nucleus|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Golgi inheritance|vascular endothelial growth factor receptor signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|nuclear import|Fc-gamma receptor signaling pathway|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|activation of MAPK activity|Fc-epsilon receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|growth hormone receptor signaling pathway|caveolin-mediated endocytosis|peptidyl-serine phosphorylation|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|RNA polymerase II carboxy-terminal domain kinase activity|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|in utero embryonic development|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|positive regulation of peptidyl-threonine phosphorylation|epidermal growth factor receptor signaling pathway|TRIF-dependent toll-like receptor signaling pathway K04371 mitogen-activated protein kinase 1/3[2.7.11.24] hsa05200|hsa04151|hsa05206|hsa04010|hsa04014|hsa04810|hsa04015|hsa05203|hsa05205|hsa04510|hsa04024|hsa04062|hsa05034|hsa05152|hsa05164|hsa04360|hsa05010|hsa04022|hsa04921|hsa04261|hsa05161|hsa04072|hsa04550|hsa04210|hsa04910|hsa04650|hsa04068|hsa05160|hsa04380|hsa04611|hsa04114|hsa04722|hsa04270|hsa04071|hsa05145|hsa04919|hsa04724|hsa04726|hsa04725|hsa04668|hsa04620|hsa05142|hsa04660|hsa04066|hsa05231|hsa04933|hsa04723|hsa04916|hsa04915|hsa04914|hsa04713|hsa04666|hsa04912|hsa05215|hsa04540|hsa04012|hsa05132|hsa04350|hsa05133|hsa04520|hsa05220|hsa05140|hsa04662|hsa04917|hsa05218|hsa05230|hsa04664|hsa04720|hsa05211|hsa05212|hsa05131|hsa05214|hsa05210|hsa04370|hsa04150|hsa04730|hsa04621|hsa05221|hsa05223|hsa05213|hsa04930|hsa05219|hsa04960|hsa05020|hsa05216|hsa04320 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Gap junction - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Melanoma - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|Glioma - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|NOD-like receptor signaling pathway - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Type II diabetes mellitus - Homo sapiens (human)|Bladder cancer - Homo sapiens (human)|Aldosterone-regulated sodium reabsorption - Homo sapiens (human)|Prion diseases - Homo sapiens (human)|Thyroid cancer - Homo sapiens (human)|Dorso-ventral axis formation - Homo sapiens (human) 22:21754500-21867680 635 765 935 3540 3941 3291 3.62562754798411 3.9696405976642 4.81321414404829 18.1096660165609 18.4622190441598 17.6102791619361 4.1361607632322 18.0607214075523 -2.12649135403445 5.34803243364232e-25 7.12768572651598e-23 DOWN ENSG00000153317 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [Source:HGNC Symbol;Acc:HGNC:2720] GO:0032502|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0048523|GO:0050794|GO:0043167|GO:0009653|GO:0016043|GO:0008289|GO:0009893|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0048468|GO:0007275|GO:0045596|GO:0016358|GO:0043168|GO:0008047|GO:0005543|GO:0051128|GO:0043169|GO:0005737|GO:0043005|GO:0043197|GO:0036477|GO:0043085|GO:0060996|GO:0050790|GO:0030030|GO:0048869|GO:0006996|GO:0050768|GO:0000902|GO:0060998|GO:0005829|GO:0031175|GO:2000171|GO:0031344|GO:0005096|GO:0046872|GO:0044309|GO:0050773|GO:0051345|GO:0035091|GO:0030695|GO:0010721|GO:0031345|GO:0030425|GO:0032990|GO:0007399|GO:0061000|GO:0030154|GO:0048858|GO:0051960|GO:0048666|GO:0030182|GO:0060271|GO:0010975|GO:0043087|GO:0043547|GO:1901981|GO:0045665|GO:0022008|GO:0050767|GO:0010977|GO:1902936|GO:0048699|GO:0005547|GO:0045664|GO:0005546 developmental process|synapse|cell|membrane|cellular process|metabolic process|binding|cell projection|negative regulation of cellular process|regulation of cellular process|ion binding|anatomical structure morphogenesis|cellular component organization|lipid binding|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cell development|multicellular organism development|negative regulation of cell differentiation|dendrite development|anion binding|enzyme activator activity|phospholipid binding|regulation of cellular component organization|cation binding|cytoplasm|neuron projection|dendritic spine|somatodendritic compartment|positive regulation of catalytic activity|dendritic spine development|regulation of catalytic activity|cell projection organization|cellular developmental process|organelle organization|negative regulation of neurogenesis|cell morphogenesis|regulation of dendritic spine development|cytosol|neuron projection development|negative regulation of dendrite development|regulation of cell projection organization|GTPase activator activity|metal ion binding|neuron spine|regulation of dendrite development|positive regulation of hydrolase activity|phosphatidylinositol binding|GTPase regulator activity|negative regulation of cell development|negative regulation of cell projection organization|dendrite|cell part morphogenesis|nervous system development|negative regulation of dendritic spine development|cell differentiation|cell projection morphogenesis|regulation of nervous system development|neuron development|neuron differentiation|cilium morphogenesis|regulation of neuron projection development|regulation of GTPase activity|positive regulation of GTPase activity|phosphatidylinositol phosphate binding|negative regulation of neuron differentiation|neurogenesis|regulation of neurogenesis|negative regulation of neuron projection development|phosphatidylinositol bisphosphate binding|generation of neurons|phosphatidylinositol-3,4,5-trisphosphate binding|regulation of neuron differentiation|phosphatidylinositol-4,5-bisphosphate binding K12488 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein[-] hsa04144|hsa04666 Endocytosis - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human) 8:130052104-130443660 340 358 744 3118 3637 3193 1.65957340867426 1.58810751754809 3.27419743411452 13.6361323581326 14.5656102987277 14.6064704530745 2.17395945344562 14.2694043699783 -2.71452817744418 6.8256291408556e-25 9.05654810538236e-23 DOWN ENSG00000241973 PI4KA phosphatidylinositol 4-kinase, catalytic, alpha [Source:HGNC Symbol;Acc:HGNC:8983] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0005622|GO:0016740|GO:0044255|GO:0016772|GO:0019637|GO:0007154|GO:0006629|GO:0007165|GO:0046486|GO:0016301|GO:0006796|GO:0035556|GO:0030258|GO:0016773|GO:0006644|GO:0016310|GO:0048017|GO:0046834|GO:0006650|GO:0048015|GO:0046854|GO:0046488 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|intracellular|transferase activity|cellular lipid metabolic process|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|cell communication|lipid metabolic process|signal transduction|glycerolipid metabolic process|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|lipid modification|phosphotransferase activity, alcohol group as acceptor|phospholipid metabolic process|phosphorylation|inositol lipid-mediated signaling|lipid phosphorylation|glycerophospholipid metabolic process|phosphatidylinositol-mediated signaling|phosphatidylinositol phosphorylation|phosphatidylinositol metabolic process K00888 phosphatidylinositol 4-kinase A[2.7.1.67] hsa01100|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 22:20707691-20859417 299 294 418 1558 1704 1604 1.16370267429218 1.03991564298467 1.46677074283845 5.43295924150878 5.4413766499186 5.85065547464571 1.22346302003843 5.57499712202436 -2.18800056458697 7.76493276690795e-25 1.02572700364279e-22 DOWN ENSG00000009844 VTA1 vesicle (multivesicular body) trafficking 1 [Source:HGNC Symbol;Acc:HGNC:20954] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0016032|GO:0008022|GO:0006810|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0061024|GO:0070062|GO:0051649|GO:0010008|GO:0005768|GO:0006996|GO:0016192|GO:0005829|GO:0006900|GO:0016050|GO:0019068|GO:0015031|GO:0071985|GO:0046907|GO:0019058|GO:0046755|GO:0016197 cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|organelle membrane|viral process|protein C-terminus binding|transport|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|membrane organization|extracellular exosome|establishment of localization in cell|endosome membrane|endosome|organelle organization|vesicle-mediated transport|cytosol|membrane budding|vesicle organization|virion assembly|protein transport|multivesicular body sorting pathway|intracellular transport|viral life cycle|viral budding|endosomal transport K12199 vacuolar protein sorting-associated protein VTA1[-] hsa04144 Endocytosis - Homo sapiens (human) 6:142147162-142224689 207 229 318 1160 1275 1176 1.3594413954353 1.36680183834043 1.88291584329449 6.82566970695929 6.87017439681887 7.23812444457361 1.53638635902341 6.97798951611726 -2.18327037008697 9.4507650750263e-25 1.24292132400808e-22 DOWN ENSG00000268205 CTC-444N24.11 - - - - - - - 19:57304305-57308562 54 48 54 417 424 341 0.897090460790889 0.724704203803508 0.808818238484921 6.20689289365605 5.77927954178268 5.30912631371957 0.810204301026439 5.76509958305277 -2.83098787958098 1.05060878701232e-24 1.37565240032744e-22 DOWN ENSG00000105778 AVL9 AVL9 homolog (S. cerevisiase) [Source:HGNC Symbol;Acc:HGNC:28994] GO:0040011|GO:0005623|GO:0016020|GO:0009987|GO:0043229|GO:0048870|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0043231|GO:0005737|GO:0006928|GO:0016477|GO:0016021|GO:0005768|GO:0055037 locomotion|cell|membrane|cellular process|intracellular organelle|cell motility|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|cell migration|integral component of membrane|endosome|recycling endosome - - - - 7:32495426-32588721 70 85 175 1298 1373 754 0.201618477512042 0.222502996920835 0.454450862487603 3.349712512747 3.2446925214686 2.03533238346778 0.29285744564016 2.87657913922779 -3.29608368231852 1.3991139741332e-24 1.82398028750099e-22 DOWN ENSG00000003249 DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28455] GO:0005623|GO:0005622|GO:0005737 cell|intracellular|cytoplasm - - - - 16:90004865-90020128 140 142 284 1169 1293 1154 1.07316456863734 0.989249771914593 1.96277628181518 8.0287980219144 8.13213910654659 8.29034898612281 1.3417302074557 8.15042870486127 -2.60278133939764 1.53087456377895e-24 1.98707518378508e-22 DOWN ENSG00000113716 HMGXB3 HMG box domain containing 3 [Source:HGNC Symbol;Acc:HGNC:28982] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0044237|GO:0043227|GO:0005622|GO:0016740|GO:0003676|GO:0016772|GO:0043231|GO:0003677|GO:0016301|GO:0006796|GO:0005634|GO:0016310 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|cellular metabolic process|membrane-bounded organelle|intracellular|transferase activity|nucleic acid binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|DNA binding|kinase activity|phosphate-containing compound metabolic process|nucleus|phosphorylation - - - - 5:150000046-150053142 295 294 274 1295 1551 1300 2.21357397406043 2.00492911968245 1.85368823683286 8.70641932572685 9.54886844180485 9.14206619856211 2.02406377685858 9.13245132203127 -2.1737474096491 2.0353751838324e-24 2.63048011853387e-22 DOWN ENSG00000218336 TENM3 teneurin transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:29944] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0071704|GO:0009653|GO:0016043|GO:0007155|GO:0031224|GO:0050793|GO:0005515|GO:0048856|GO:0042802|GO:0045595|GO:0048468|GO:0051130|GO:0007275|GO:0048513|GO:0051128|GO:0098609|GO:0045597|GO:0007423|GO:0009887|GO:0043005|GO:0046983|GO:0007154|GO:0007165|GO:0030030|GO:0048869|GO:0016021|GO:0019538|GO:0031175|GO:0098742|GO:0031344|GO:0001654|GO:0030424|GO:0010720|GO:0046982|GO:0031346|GO:0050769|GO:0006508|GO:0007399|GO:0030154|GO:0042803|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0043010|GO:0097264|GO:0007156|GO:0022008|GO:0050767|GO:0010976|GO:0048592|GO:0045666|GO:0048593|GO:0048699|GO:0045664 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|organic substance metabolic process|anatomical structure morphogenesis|cellular component organization|cell adhesion|intrinsic component of membrane|regulation of developmental process|protein binding|anatomical structure development|identical protein binding|regulation of cell differentiation|cell development|positive regulation of cellular component organization|multicellular organism development|animal organ development|regulation of cellular component organization|cell-cell adhesion|positive regulation of cell differentiation|sensory organ development|organ morphogenesis|neuron projection|protein dimerization activity|cell communication|signal transduction|cell projection organization|cellular developmental process|integral component of membrane|protein metabolic process|neuron projection development|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of cell projection organization|eye development|axon|positive regulation of cell development|protein heterodimerization activity|positive regulation of cell projection organization|positive regulation of neurogenesis|proteolysis|nervous system development|cell differentiation|protein homodimerization activity|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|camera-type eye development|self proteolysis|homophilic cell adhesion via plasma membrane adhesion molecules|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|eye morphogenesis|positive regulation of neuron differentiation|camera-type eye morphogenesis|generation of neurons|regulation of neuron differentiation - - - - 4:182143987-182803024 53 61 118 661 706 541 0.274735782546167 0.287377682213184 0.551488340213321 3.07000592945528 3.00270920302485 2.6282501334729 0.371200601657557 2.90032175531768 -2.9659420045731 2.18972444885668e-24 2.81776007311066e-22 DOWN ENSG00000083097 DOPEY1 dopey family member 1 [Source:HGNC Symbol;Acc:HGNC:21194] GO:0005623|GO:0016020|GO:0009987|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0051649|GO:0010256|GO:0005794|GO:0006996|GO:0016192|GO:0015031|GO:0046907|GO:0007029|GO:0000139|GO:0048193|GO:0016482|GO:0016197|GO:0006892|GO:0006895 cell|membrane|cellular process|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|establishment of localization in cell|endomembrane system organization|Golgi apparatus|organelle organization|vesicle-mediated transport|protein transport|intracellular transport|endoplasmic reticulum organization|Golgi membrane|Golgi vesicle transport|cytosolic transport|endosomal transport|post-Golgi vesicle-mediated transport|Golgi to endosome transport - - - - 6:83067666-83171350 52 56 52 377 407 353 0.257316827992394 0.251842526507722 0.231996639067881 1.67147813607038 1.6524352844189 1.63706399593224 0.247051997855999 1.65365913880717 -2.74277526131732 2.56298936108723e-24 3.28392636849348e-22 DOWN ENSG00000196730 DAPK1 death-associated protein kinase 1 [Source:HGNC Symbol;Acc:HGNC:2674] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0006914|GO:0023051|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0019222|GO:0042802|GO:0050804|GO:0010506|GO:0045087|GO:0006810|GO:0010941|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0010942|GO:0005737|GO:0007267|GO:0009966|GO:0009890|GO:0060548|GO:0010646|GO:0000149|GO:0043085|GO:0005516|GO:0007154|GO:0055085|GO:0007165|GO:0009968|GO:0008219|GO:0050790|GO:0000166|GO:0044249|GO:0010469|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0007166|GO:0035639|GO:0043412|GO:0034097|GO:0051345|GO:0010629|GO:0043069|GO:2001234|GO:0001883|GO:0036211|GO:0032269|GO:0006811|GO:0032549|GO:0034341|GO:0051247|GO:0006508|GO:0034765|GO:0016301|GO:0043269|GO:0032270|GO:0012501|GO:0006796|GO:0043603|GO:0035556|GO:0044267|GO:0010467|GO:0071310|GO:0017076|GO:0051246|GO:0009059|GO:0043068|GO:0019905|GO:0016773|GO:0005856|GO:0043067|GO:0022898|GO:0097190|GO:0034220|GO:2001237|GO:0015629|GO:0032561|GO:0043043|GO:2000310|GO:0007215|GO:0043065|GO:0071346|GO:0017148|GO:0005524|GO:0030162|GO:0097192|GO:0045862|GO:2001236|GO:0030554|GO:0016310|GO:0010608|GO:0052547|GO:0006412|GO:0032412|GO:0006417|GO:0017075|GO:0042981|GO:0071345|GO:0043066|GO:0004672|GO:0005525|GO:0006464|GO:0010952|GO:0019001|GO:0097191|GO:0006915|GO:0010950|GO:0043281|GO:0006468|GO:0004674|GO:1902042|GO:0043280|GO:0008625|GO:0007268|GO:1902041|GO:0052548|GO:2001056|GO:0046777|GO:2000116|GO:0004683 immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|autophagy|regulation of signaling|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|transferase activity|regulation of metabolic process|identical protein binding|modulation of synaptic transmission|regulation of autophagy|innate immune response|transport|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|positive regulation of cell death|cytoplasm|cell-cell signaling|regulation of signal transduction|negative regulation of biosynthetic process|negative regulation of cell death|regulation of cell communication|SNARE binding|positive regulation of catalytic activity|calmodulin binding|cell communication|transmembrane transport|signal transduction|negative regulation of signal transduction|cell death|regulation of catalytic activity|nucleotide binding|cellular biosynthetic process|regulation of receptor activity|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|response to cytokine|positive regulation of hydrolase activity|negative regulation of gene expression|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|purine nucleoside binding|protein modification process|negative regulation of cellular protein metabolic process|ion transport|ribonucleoside binding|response to interferon-gamma|positive regulation of protein metabolic process|proteolysis|regulation of ion transmembrane transport|kinase activity|regulation of ion transport|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|cellular response to organic substance|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of programmed cell death|syntaxin binding|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|regulation of programmed cell death|regulation of transmembrane transporter activity|apoptotic signaling pathway|ion transmembrane transport|negative regulation of extrinsic apoptotic signaling pathway|actin cytoskeleton|guanyl ribonucleotide binding|peptide biosynthetic process|regulation of N-methyl-D-aspartate selective glutamate receptor activity|glutamate receptor signaling pathway|positive regulation of apoptotic process|cellular response to interferon-gamma|negative regulation of translation|ATP binding|regulation of proteolysis|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of proteolysis|regulation of extrinsic apoptotic signaling pathway|adenyl nucleotide binding|phosphorylation|posttranscriptional regulation of gene expression|regulation of peptidase activity|translation|regulation of ion transmembrane transporter activity|regulation of translation|syntaxin-1 binding|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|protein kinase activity|GTP binding|cellular protein modification process|positive regulation of peptidase activity|guanyl nucleotide binding|extrinsic apoptotic signaling pathway|apoptotic process|positive regulation of endopeptidase activity|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|protein serine/threonine kinase activity|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|extrinsic apoptotic signaling pathway via death domain receptors|synaptic transmission|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|protein autophosphorylation|regulation of cysteine-type endopeptidase activity|calmodulin-dependent protein kinase activity K08803 death-associated protein kinase[2.7.11.1] hsa05200|hsa05219 Pathways in cancer - Homo sapiens (human)|Bladder cancer - Homo sapiens (human) 9:87497228-87708633 50 58 81 506 498 869 0.164060240713705 0.172959621513407 0.239625908750786 1.48759724508088 1.34070837958006 2.67230614892515 0.192215256992633 1.83353725786203 -3.25383482322639 2.63727638510445e-24 3.36466876926958e-22 DOWN ENSG00000047230 CTPS2 CTP synthase 2 [Source:HGNC Symbol;Acc:HGNC:2520] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0006139|GO:0055086|GO:0000166|GO:0044249|GO:0005829|GO:0035639|GO:0015949|GO:0019693|GO:0001883|GO:0009116|GO:0003883|GO:0032549|GO:0005739|GO:0006796|GO:1901137|GO:0017076|GO:0006213|GO:0009142|GO:0009259|GO:0009117|GO:0006220|GO:0005524|GO:0046390|GO:0030554|GO:0019752|GO:0009165|GO:0006541|GO:0046134|GO:0006221|GO:0009220|GO:0006241|GO:0044210 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|nucleotide binding|cellular biosynthetic process|cytosol|purine ribonucleoside triphosphate binding|nucleobase-containing small molecule interconversion|ribose phosphate metabolic process|purine nucleoside binding|nucleoside metabolic process|CTP synthase activity|ribonucleoside binding|mitochondrion|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|purine nucleotide binding|pyrimidine nucleoside metabolic process|nucleoside triphosphate biosynthetic process|ribonucleotide metabolic process|nucleotide metabolic process|pyrimidine nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|adenyl nucleotide binding|carboxylic acid metabolic process|nucleotide biosynthetic process|glutamine metabolic process|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process|pyrimidine ribonucleotide biosynthetic process|CTP biosynthetic process|'de novo' CTP biosynthetic process K01937 CTP synthase[6.3.4.2] hsa01100|hsa00240 Metabolic pathways - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human) X:16588003-16712936 95 106 166 731 813 665 0.911555433307884 0.924369780301325 1.43609463348338 6.28456760165505 6.40057018890436 5.98013992125126 1.0906732823642 6.22175923727022 -2.5121035696007 2.87014243865038e-24 3.64618010057312e-22 DOWN ENSG00000166377 ATP9B ATPase, class II, type 9B [Source:HGNC Symbol;Acc:HGNC:13541] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0097035|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0045184|GO:0005319|GO:0008104|GO:0061024|GO:0051649|GO:0000166|GO:0016021|GO:0010876|GO:0005794|GO:0005768|GO:0016192|GO:0005802|GO:0046872|GO:0035639|GO:0005548|GO:0072594|GO:0001883|GO:0016818|GO:0046907|GO:0006811|GO:0032549|GO:0006869|GO:0048471|GO:0034613|GO:0017076|GO:0015914|GO:0072600|GO:0045332|GO:0006820|GO:0015711|GO:0033365|GO:0000287|GO:0005524|GO:0030554|GO:0048193|GO:0004012|GO:0006897|GO:0016462|GO:0034067|GO:0017111|GO:0006890|GO:0016887|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|regulation of membrane lipid distribution|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|establishment of protein localization|lipid transporter activity|protein localization|membrane organization|establishment of localization in cell|nucleotide binding|integral component of membrane|lipid localization|Golgi apparatus|endosome|vesicle-mediated transport|trans-Golgi network|metal ion binding|purine ribonucleoside triphosphate binding|phospholipid transporter activity|establishment of protein localization to organelle|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ion transport|ribonucleoside binding|lipid transport|perinuclear region of cytoplasm|cellular protein localization|purine nucleotide binding|phospholipid transport|establishment of protein localization to Golgi|phospholipid translocation|anion transport|organic anion transport|protein localization to organelle|magnesium ion binding|ATP binding|adenyl nucleotide binding|Golgi vesicle transport|phospholipid-translocating ATPase activity|endocytosis|pyrophosphatase activity|protein localization to Golgi apparatus|nucleoside-triphosphatase activity|retrograde vesicle-mediated transport, Golgi to ER|ATPase activity|ATPase activity, coupled|ATPase activity, coupled to movement of substances - - - - 18:79069285-79378283 16 16 15 188 170 168 0.0509568802899257 0.046310244170236 0.0430704338289061 0.536455611220236 0.444217092020521 0.501436925778428 0.0467791860963559 0.494036543006395 -3.4006790935499 3.01109752301103e-24 3.80903836660895e-22 DOWN ENSG00000073792 IGF2BP2 insulin like growth factor 2 mRNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:28867] GO:0032502|GO:0005623|GO:0045182|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006810|GO:0003676|GO:0034641|GO:0001817|GO:0043231|GO:0005737|GO:0001816|GO:0009890|GO:0006403|GO:0000166|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0042107|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0042089|GO:0006518|GO:0003723|GO:0010629|GO:0032269|GO:0042035|GO:0050658|GO:0043603|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0005856|GO:0005634|GO:0043043|GO:0051028|GO:0017148|GO:0010608|GO:0006412|GO:0006417|GO:0044822|GO:0003729|GO:0048027|GO:0003730 developmental process|cell|translation regulator activity|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|transport|nucleic acid binding|cellular nitrogen compound metabolic process|regulation of cytokine production|intracellular membrane-bounded organelle|cytoplasm|cytokine production|negative regulation of biosynthetic process|RNA localization|nucleotide binding|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cytokine metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|cytokine biosynthetic process|peptide metabolic process|RNA binding|negative regulation of gene expression|negative regulation of cellular protein metabolic process|regulation of cytokine biosynthetic process|RNA transport|cellular amide metabolic process|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|cytoskeleton|nucleus|peptide biosynthetic process|mRNA transport|negative regulation of translation|posttranscriptional regulation of gene expression|translation|regulation of translation|poly(A) RNA binding|mRNA binding|mRNA 5'-UTR binding|mRNA 3'-UTR binding - - - - 3:185643739-185825056 185 177 427 1944 2213 2662 1.62947810041403 1.41686999036897 3.39092607955204 15.3415776097502 15.9928371158373 21.9741995336959 2.14575805677835 17.7695380864278 -3.04984685898893 3.41252568168203e-24 4.29863045151626e-22 DOWN ENSG00000198707 CEP290 centrosomal protein 290kDa [Source:HGNC Symbol;Acc:HGNC:29021] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:1903829|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0019222|GO:0060341|GO:0007049|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0000930|GO:0006810|GO:0022402|GO:1901360|GO:0048839|GO:0007275|GO:0048513|GO:0034641|GO:0030902|GO:0031325|GO:0046483|GO:0007420|GO:0022607|GO:0043231|GO:0005737|GO:0060322|GO:0007423|GO:0032880|GO:0051222|GO:0009887|GO:0048729|GO:0048598|GO:0048568|GO:0045184|GO:0072372|GO:0036038|GO:0032388|GO:0006139|GO:0008104|GO:0035869|GO:0051649|GO:0030916|GO:0090316|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0006996|GO:0000902|GO:0005829|GO:0005813|GO:0010468|GO:0034645|GO:0001654|GO:0002009|GO:1903047|GO:0007417|GO:0001655|GO:0043583|GO:0048793|GO:0051252|GO:0005815|GO:0032386|GO:0044770|GO:0051223|GO:0015031|GO:0009790|GO:0010628|GO:0005814|GO:0044782|GO:0000278|GO:0070201|GO:0046907|GO:0072001|GO:0042472|GO:0030031|GO:0034613|GO:0070925|GO:0060429|GO:0042384|GO:0010467|GO:0032990|GO:0048562|GO:0007399|GO:0031328|GO:0071599|GO:0009059|GO:0030154|GO:0048858|GO:1903827|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0031513|GO:0048666|GO:0030182|GO:0060271|GO:0042461|GO:0071600|GO:0045893|GO:0033157|GO:0032391|GO:0000086|GO:0032774|GO:0044772|GO:2001141|GO:0006886|GO:0042471|GO:0015630|GO:0034451|GO:0022008|GO:0006351|GO:0006355|GO:0048592|GO:0048699|GO:1903506|GO:0001754|GO:0042462 developmental process|macromolecular complex|cell|membrane|cellular process|metabolic process|binding|cell projection|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|positive regulation of cellular protein localization|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cellular localization|cell cycle|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|gamma-tubulin complex|transport|cell cycle process|organic cyclic compound metabolic process|inner ear development|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|hindbrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|head development|sensory organ development|regulation of protein localization|positive regulation of protein transport|organ morphogenesis|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|establishment of protein localization|primary cilium|TCTN-B9D complex|positive regulation of intracellular transport|nucleobase-containing compound metabolic process|protein localization|ciliary transition zone|establishment of localization in cell|otic vesicle formation|positive regulation of intracellular protein transport|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|cell morphogenesis|cytosol|centrosome|regulation of gene expression|cellular macromolecule biosynthetic process|eye development|morphogenesis of an epithelium|mitotic cell cycle process|central nervous system development|urogenital system development|ear development|pronephros development|regulation of RNA metabolic process|microtubule organizing center|regulation of intracellular transport|cell cycle phase transition|regulation of protein transport|protein transport|embryo development|positive regulation of gene expression|centriole|cilium organization|mitotic cell cycle|regulation of establishment of protein localization|intracellular transport|renal system development|inner ear morphogenesis|cell projection assembly|cellular protein localization|organelle assembly|epithelium development|cilium assembly|gene expression|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|positive regulation of cellular biosynthetic process|otic vesicle development|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|regulation of cellular protein localization|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|nonmotile primary cilium|neuron development|neuron differentiation|cilium morphogenesis|photoreceptor cell development|otic vesicle morphogenesis|positive regulation of transcription, DNA-templated|regulation of intracellular protein transport|photoreceptor connecting cilium|G2/M transition of mitotic cell cycle|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|intracellular protein transport|ear morphogenesis|microtubule cytoskeleton|centriolar satellite|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|generation of neurons|regulation of nucleic acid-templated transcription|eye photoreceptor cell differentiation|eye photoreceptor cell development - - - - 12:88049014-88142216 56 72 111 514 567 571 0.324110481749627 0.378717538021028 0.579217550380531 2.66541222633843 2.69249455336182 3.09719237710309 0.427348523383729 2.81836638560111 -2.72137413059228 3.7151504813871e-24 4.66017237274498e-22 DOWN ENSG00000196792 STRN3 striatin 3 [Source:HGNC Symbol;Acc:HGNC:15720] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0042995|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0044297|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0008287|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0019222|GO:0006725|GO:0043025|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0032403|GO:0043005|GO:0009966|GO:0009890|GO:0036477|GO:0000159|GO:0019904|GO:0010646|GO:0006139|GO:0005516|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0005794|GO:0010468|GO:0034645|GO:0033993|GO:0010629|GO:0051252|GO:0010628|GO:0019902|GO:0031981|GO:0030425|GO:0005654|GO:0033143|GO:0033144|GO:0014070|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0009755|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0070016|GO:0048545|GO:0097305|GO:0030522|GO:0043401|GO:0045893|GO:0045892|GO:0032774|GO:2001141|GO:0043627|GO:1902679|GO:0071383|GO:0071407|GO:0030518|GO:0019903|GO:0032355|GO:0033147|GO:0071396|GO:0006351|GO:0006355|GO:0033146|GO:0030520|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122|GO:0051721 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|cell projection|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|cell body|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|protein serine/threonine phosphatase complex|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|regulation of metabolic process|cellular aromatic compound metabolic process|neuronal cell body|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein complex binding|neuron projection|regulation of signal transduction|negative regulation of biosynthetic process|somatodendritic compartment|protein phosphatase type 2A complex|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|calmodulin binding|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|phosphatase binding|nuclear lumen|dendrite|nucleoplasm|regulation of intracellular steroid hormone receptor signaling pathway|negative regulation of intracellular steroid hormone receptor signaling pathway|response to organic cyclic compound|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|armadillo repeat domain binding|response to steroid hormone|response to alcohol|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|response to estrogen|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|protein phosphatase binding|response to estradiol|negative regulation of intracellular estrogen receptor signaling pathway|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of intracellular estrogen receptor signaling pathway|intracellular estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter|protein phosphatase 2A binding - - - - 14:30893799-31026401 169 211 232 974 1148 886 1.66335541342779 1.88738711052477 2.05873209588355 8.58924428221394 9.2706018086983 8.17261370021573 1.8698248732787 8.67748659704266 -2.21437407726366 4.25149418344202e-24 5.31063210679825e-22 DOWN ENSG00000120451 SNX19 sorting nexin 19 [Source:HGNC Symbol;Acc:HGNC:21532] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0009888|GO:0006810|GO:0007275|GO:0048513|GO:0043168|GO:0032940|GO:0005543|GO:0031982|GO:0043231|GO:0005737|GO:0007267|GO:0012506|GO:0045184|GO:0008104|GO:0007154|GO:0010008|GO:0010817|GO:0048869|GO:0005768|GO:0006996|GO:0016192|GO:0051216|GO:0016050|GO:0031410|GO:0005769|GO:0035091|GO:0015031|GO:0016023|GO:0006887|GO:0042886|GO:0009914|GO:0009306|GO:0031988|GO:0031901|GO:0030659|GO:0046903|GO:0030154|GO:0001501|GO:0061448|GO:0002790|GO:0030073|GO:0002062|GO:0015833|GO:1901981|GO:0046879|GO:1990502|GO:0030072|GO:0032266 developmental process|signaling|cell|membrane|cellular process|binding|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|lipid binding|intracellular|protein binding|endomembrane system|anatomical structure development|organelle membrane|tissue development|transport|multicellular organism development|animal organ development|anion binding|secretion by cell|phospholipid binding|vesicle|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|vesicle membrane|establishment of protein localization|protein localization|cell communication|endosome membrane|regulation of hormone levels|cellular developmental process|endosome|organelle organization|vesicle-mediated transport|cartilage development|vesicle organization|cytoplasmic vesicle|early endosome|phosphatidylinositol binding|protein transport|cytoplasmic, membrane-bounded vesicle|exocytosis|amide transport|hormone transport|protein secretion|membrane-bounded vesicle|early endosome membrane|cytoplasmic vesicle membrane|secretion|cell differentiation|skeletal system development|connective tissue development|peptide secretion|insulin secretion|chondrocyte differentiation|peptide transport|phosphatidylinositol phosphate binding|hormone secretion|dense core granule maturation|peptide hormone secretion|phosphatidylinositol-3-phosphate binding - - - - 11:130875436-130916509 203 246 290 1058 1211 1115 0.93872060001575 1.03384168866125 1.20907157224101 4.38351950844019 4.5946413846184 4.83218371623251 1.060544620306 4.60344820309703 -2.11790959308539 4.38274649712106e-24 5.45177141354383e-22 DOWN ENSG00000068976 PYGM phosphorylase, glycogen, muscle [Source:HGNC Symbol;Acc:HGNC:9726] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0008144|GO:0009628|GO:0044237|GO:0030246|GO:0043227|GO:0048037|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0044262|GO:0043168|GO:0015980|GO:0044281|GO:0001882|GO:0031982|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0005975|GO:0042592|GO:0019725|GO:0005783|GO:0070062|GO:0016757|GO:0030170|GO:0001666|GO:0000166|GO:0006091|GO:0010033|GO:0055114|GO:0005829|GO:0005976|GO:0016528|GO:0014074|GO:0016208|GO:0048878|GO:0046683|GO:0001883|GO:0044275|GO:0032549|GO:0055082|GO:0016758|GO:0005977|GO:0005996|GO:0051591|GO:0016052|GO:0006112|GO:0014070|GO:0017076|GO:0016529|GO:0019318|GO:0005980|GO:0030554|GO:0004645|GO:0050801|GO:0000272|GO:0006873|GO:0008184|GO:0006006|GO:0030003|GO:0055065|GO:0006875|GO:0006874|GO:0055074 cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|drug binding|response to abiotic stimulus|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|cofactor binding|intracellular|protein binding|endomembrane system|transferase activity|cellular carbohydrate metabolic process|anion binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|nucleoside binding|vesicle|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|carbohydrate metabolic process|homeostatic process|cellular homeostasis|endoplasmic reticulum|extracellular exosome|transferase activity, transferring glycosyl groups|pyridoxal phosphate binding|response to hypoxia|nucleotide binding|generation of precursor metabolites and energy|response to organic substance|oxidation-reduction process|cytosol|polysaccharide metabolic process|sarcoplasm|response to purine-containing compound|AMP binding|chemical homeostasis|response to organophosphorus|purine nucleoside binding|cellular carbohydrate catabolic process|ribonucleoside binding|cellular chemical homeostasis|transferase activity, transferring hexosyl groups|glycogen metabolic process|monosaccharide metabolic process|response to cAMP|carbohydrate catabolic process|energy reserve metabolic process|response to organic cyclic compound|purine nucleotide binding|sarcoplasmic reticulum|hexose metabolic process|glycogen catabolic process|adenyl nucleotide binding|phosphorylase activity|ion homeostasis|polysaccharide catabolic process|cellular ion homeostasis|glycogen phosphorylase activity|glucose metabolic process|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis K00688 starch phosphorylase[2.4.1.1] hsa01100|hsa04910|hsa04931|hsa04922|hsa00500 Metabolic pathways - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human) 11:64746389-64760297 379 265 159 4 7 14 4.62627199049338 2.93980422357399 1.7498665484451 0.0437486471833199 0.0701066831826863 0.160162462258647 3.10531425417082 0.0913392642082177 5.08736029665788 4.40641454920028e-24 5.45846887766909e-22 UP ENSG00000114107 CEP70 centrosomal protein 70kDa [Source:HGNC Symbol;Acc:HGNC:29972] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0007049|GO:0022402|GO:0043231|GO:0005737|GO:0005635|GO:0031965|GO:0006996|GO:0005829|GO:0005813|GO:1903047|GO:0005815|GO:0044770|GO:0000278|GO:0031981|GO:0005654|GO:0005856|GO:0005634|GO:0000086|GO:0044772|GO:0015630 cell|membrane|cellular process|binding|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|organelle membrane|cell cycle|cell cycle process|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|nuclear membrane|organelle organization|cytosol|centrosome|mitotic cell cycle process|microtubule organizing center|cell cycle phase transition|mitotic cell cycle|nuclear lumen|nucleoplasm|cytoskeleton|nucleus|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|microtubule cytoskeleton - - - - 3:138494344-138594538 103 106 198 857 848 1058 1.16518813671517 1.08978954427976 2.01946594491933 8.68632069646794 7.87083713062871 11.2168772114866 1.42481454197142 9.25801167952775 -2.69992823658479 4.9198117605195e-24 6.04428231681272e-22 DOWN ENSG00000214655 ZSWIM8 zinc finger, SWIM-type containing 8 [Source:HGNC Symbol;Acc:HGNC:23528] GO:0005488|GO:0043167|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 10:73785582-73801797 259 298 351 1244 1339 1445 0.988444621820123 1.03359136873821 1.20774366818666 4.25374436451084 4.192777217001 5.16832805153069 1.07659321958166 4.53828321101418 -2.07567339866953 4.9176261535962e-24 6.04428231681272e-22 DOWN ENSG00000251003 ZFPM2-AS1 ZFPM2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:50698] - - - - - - 8:105780246-106060524 12 14 17 155 160 199 0.254915620518582 0.27027694567777 0.325583636566745 2.95005390507301 2.78862043255856 3.96170727189944 0.283592067587699 3.23346053651034 -3.51118991846668 5.09414355764324e-24 6.23280990860169e-22 DOWN ENSG00000186088 GSAP gamma-secretase activating protein [Source:HGNC Symbol;Acc:HGNC:28042] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0033218|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0005622|GO:0012505|GO:0019222|GO:0042277|GO:0034641|GO:0031325|GO:0043231|GO:0005737|GO:0019538|GO:0031323|GO:0005794|GO:0005802|GO:0006518|GO:0051247|GO:0006508|GO:0043603|GO:0042982|GO:0051246|GO:0001540|GO:0030162|GO:0042987|GO:1902004|GO:0050435|GO:1902003|GO:1902991|GO:0034205 cell|cellular process|metabolic process|binding|amide binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intracellular|endomembrane system|regulation of metabolic process|peptide binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cytoplasm|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|trans-Golgi network|peptide metabolic process|positive regulation of protein metabolic process|proteolysis|cellular amide metabolic process|amyloid precursor protein metabolic process|regulation of protein metabolic process|beta-amyloid binding|regulation of proteolysis|amyloid precursor protein catabolic process|positive regulation of beta-amyloid formation|beta-amyloid metabolic process|regulation of beta-amyloid formation|regulation of amyloid precursor protein catabolic process|beta-amyloid formation - - - - 7:77310751-77416400 25 32 60 334 377 408 0.139863845707646 0.162701175777462 0.302642863923527 1.67419325137222 1.7304937535135 2.13919399858654 0.201735961802878 1.84796033449075 -3.19539360107421 5.17376230308308e-24 6.30438774678539e-22 DOWN ENSG00000171310 CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 [Source:HGNC Symbol;Acc:HGNC:17422] GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0043227|GO:0023057|GO:0009058|GO:0031224|GO:0048589|GO:0005622|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0042127|GO:0007585|GO:0009791|GO:0009888|GO:0048468|GO:0010941|GO:0006082|GO:0036342|GO:0007275|GO:0048513|GO:0044281|GO:0090287|GO:0043231|GO:0005737|GO:0005975|GO:0071559|GO:0009887|GO:0033037|GO:0009966|GO:0048598|GO:0048568|GO:0060548|GO:0010646|GO:0090288|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0005794|GO:0006790|GO:0048705|GO:0034645|GO:0051216|GO:0090101|GO:0042733|GO:0007166|GO:0043069|GO:0002063|GO:0030204|GO:0009790|GO:0009100|GO:0071560|GO:0070848|GO:0012501|GO:1901137|GO:0035108|GO:0008146|GO:0048562|GO:0048701|GO:0071310|GO:0000139|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0060173|GO:0048703|GO:0016051|GO:0043067|GO:0048706|GO:0009101|GO:0009792|GO:0002062|GO:0030206|GO:0071363|GO:0007179|GO:0030512|GO:0007167|GO:0050659|GO:0050650|GO:0001537|GO:0006024|GO:0042981|GO:0006029|GO:0043066|GO:0048704|GO:0030203|GO:0030326|GO:0017015|GO:0006915|GO:0047756|GO:0043009|GO:0007178|GO:0030166 developmental process|growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intrinsic component of membrane|developmental growth|intracellular|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of cell proliferation|respiratory gaseous exchange|post-embryonic development|tissue development|cell development|regulation of cell death|organic acid metabolic process|post-anal tail morphogenesis|multicellular organism development|animal organ development|small molecule metabolic process|regulation of cellular response to growth factor stimulus|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|response to transforming growth factor beta|organ morphogenesis|polysaccharide localization|regulation of signal transduction|embryonic morphogenesis|embryonic organ development|negative regulation of cell death|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|cell communication|signal transduction|negative regulation of signal transduction|cell death|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|Golgi apparatus|sulfur compound metabolic process|skeletal system morphogenesis|cellular macromolecule biosynthetic process|cartilage development|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|embryonic digit morphogenesis|cell surface receptor signaling pathway|negative regulation of programmed cell death|chondrocyte development|chondroitin sulfate metabolic process|embryo development|glycoprotein metabolic process|cellular response to transforming growth factor beta stimulus|response to growth factor|programmed cell death|carbohydrate derivative biosynthetic process|limb morphogenesis|sulfotransferase activity|embryonic organ morphogenesis|embryonic cranial skeleton morphogenesis|cellular response to organic substance|Golgi membrane|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|limb development|embryonic viscerocranium morphogenesis|carbohydrate biosynthetic process|regulation of programmed cell death|embryonic skeletal system development|glycoprotein biosynthetic process|embryo development ending in birth or egg hatching|chondrocyte differentiation|chondroitin sulfate biosynthetic process|cellular response to growth factor stimulus|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity|chondroitin sulfate proteoglycan biosynthetic process|N-acetylgalactosamine 4-O-sulfotransferase activity|glycosaminoglycan biosynthetic process|regulation of apoptotic process|proteoglycan metabolic process|negative regulation of apoptotic process|embryonic skeletal system morphogenesis|glycosaminoglycan metabolic process|embryonic limb morphogenesis|regulation of transforming growth factor beta receptor signaling pathway|apoptotic process|chondroitin 4-sulfotransferase activity|chordate embryonic development|transmembrane receptor protein serine/threonine kinase signaling pathway|proteoglycan biosynthetic process K01017 chondroitin 4-sulfotransferase 11[2.8.2.5] hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human) 12:104455295-104762014 49 39 110 597 864 661 0.391429727479654 0.283143445030105 0.792251324062933 4.27296653880807 5.66289659737193 4.94865928867341 0.488941498857564 4.96150747495114 -3.34304476286292 5.20823670758333e-24 6.3205975068371e-22 DOWN ENSG00000079691 LRRC16A leucine rich repeat containing 16A [Source:HGNC Symbol;Acc:HGNC:21581] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0042995|GO:0048523|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044089|GO:0071704|GO:0044237|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0031252|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0051272|GO:0050817|GO:0045595|GO:0006725|GO:0048468|GO:0051130|GO:1901360|GO:0005884|GO:0006082|GO:0034446|GO:0032535|GO:0034641|GO:0044281|GO:0030155|GO:0031982|GO:0046483|GO:0051128|GO:2000147|GO:0022607|GO:0045597|GO:0043231|GO:0005737|GO:0032970|GO:0009611|GO:0006928|GO:0032403|GO:0031589|GO:0030027|GO:0032231|GO:0051270|GO:0016477|GO:0032233|GO:0070062|GO:0045785|GO:0031941|GO:0030030|GO:0048869|GO:0030029|GO:2000145|GO:0031334|GO:0043254|GO:0050878|GO:0006996|GO:0051017|GO:0000902|GO:0005829|GO:0031333|GO:0031344|GO:0032956|GO:1900026|GO:0007010|GO:0010720|GO:0007596|GO:0031346|GO:0000904|GO:0046415|GO:0030334|GO:0042060|GO:2000813|GO:0043242|GO:0007599|GO:0030031|GO:0010810|GO:0022604|GO:0006461|GO:0043244|GO:0030036|GO:0097581|GO:0032273|GO:0033043|GO:1900024|GO:0010770|GO:0031529|GO:0010811|GO:0030154|GO:0030832|GO:0030335|GO:0051496|GO:0043243|GO:0005856|GO:0005634|GO:0051492|GO:0010638|GO:0015629|GO:0043241|GO:0030032|GO:1902745|GO:0034622|GO:0030838|GO:0010769|GO:1901881|GO:0043623|GO:0008064|GO:0051494|GO:0051493|GO:0032272|GO:1901879|GO:0031032|GO:0030038|GO:0007015|GO:0051495|GO:0030833|GO:0030836|GO:0051258|GO:2000812|GO:0043624|GO:0030837|GO:0043149|GO:0030834|GO:0061572|GO:0008154|GO:0030835|GO:0051695|GO:0051693|GO:0030042|GO:0030041|GO:0051261|GO:0051016|GO:0051638 locomotion|developmental process|macromolecular complex|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cell projection|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|cellular metabolic process|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell leading edge|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|positive regulation of cellular component movement|coagulation|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|positive regulation of cellular component organization|organic cyclic compound metabolic process|actin filament|organic acid metabolic process|substrate adhesion-dependent cell spreading|regulation of cellular component size|cellular nitrogen compound metabolic process|small molecule metabolic process|regulation of cell adhesion|vesicle|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|regulation of actin filament-based process|response to wounding|movement of cell or subcellular component|protein complex binding|cell-substrate adhesion|lamellipodium|regulation of actin filament bundle assembly|regulation of cellular component movement|cell migration|positive regulation of actin filament bundle assembly|extracellular exosome|positive regulation of cell adhesion|filamentous actin|cell projection organization|cellular developmental process|actin filament-based process|regulation of cell motility|positive regulation of protein complex assembly|regulation of protein complex assembly|regulation of body fluid levels|organelle organization|actin filament bundle assembly|cell morphogenesis|cytosol|negative regulation of protein complex assembly|regulation of cell projection organization|regulation of actin cytoskeleton organization|positive regulation of substrate adhesion-dependent cell spreading|cytoskeleton organization|positive regulation of cell development|blood coagulation|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|urate metabolic process|regulation of cell migration|wound healing|negative regulation of barbed-end actin filament capping|negative regulation of protein complex disassembly|hemostasis|cell projection assembly|regulation of cell-substrate adhesion|regulation of cell morphogenesis|protein complex assembly|regulation of protein complex disassembly|actin cytoskeleton organization|lamellipodium organization|positive regulation of protein polymerization|regulation of organelle organization|regulation of substrate adhesion-dependent cell spreading|positive regulation of cell morphogenesis involved in differentiation|ruffle organization|positive regulation of cell-substrate adhesion|cell differentiation|regulation of actin filament length|positive regulation of cell migration|positive regulation of stress fiber assembly|positive regulation of protein complex disassembly|cytoskeleton|nucleus|regulation of stress fiber assembly|positive regulation of organelle organization|actin cytoskeleton|protein complex disassembly|lamellipodium assembly|positive regulation of lamellipodium organization|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|regulation of cell morphogenesis involved in differentiation|positive regulation of protein depolymerization|cellular protein complex assembly|regulation of actin polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|regulation of protein depolymerization|actomyosin structure organization|contractile actin filament bundle assembly|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|positive regulation of actin filament depolymerization|protein polymerization|regulation of barbed-end actin filament capping|cellular protein complex disassembly|negative regulation of actin filament polymerization|stress fiber assembly|regulation of actin filament depolymerization|actin filament bundle organization|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|actin filament uncapping|actin filament capping|actin filament depolymerization|actin filament polymerization|protein depolymerization|barbed-end actin filament capping|barbed-end actin filament uncapping - - - - 6:25279078-25620530 116 109 220 914 958 984 1.09130082027936 0.931951902018413 1.86605103039078 7.7042393584633 7.39467587560849 8.67580175485054 1.29643458422952 7.92490566297411 -2.61184434948767 5.8250187216483e-24 7.04049023951774e-22 DOWN ENSG00000075461 CACNG4 calcium channel, voltage-dependent, gamma subunit 4 [Source:HGNC Symbol;Acc:HGNC:1408] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0022857|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0071944|GO:0031224|GO:0016247|GO:0005622|GO:0005886|GO:0043234|GO:0031090|GO:0050804|GO:0042391|GO:0006810|GO:0098797|GO:0050877|GO:0031982|GO:0005887|GO:0043231|GO:0005737|GO:0007267|GO:0012506|GO:0043235|GO:0030666|GO:0009966|GO:0022891|GO:0010646|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0016021|GO:0010469|GO:0008328|GO:0007166|GO:0051899|GO:0031410|GO:0016023|GO:0015267|GO:0006811|GO:0015075|GO:0005891|GO:0019226|GO:0031988|GO:0034765|GO:0034702|GO:0043269|GO:0030659|GO:0022898|GO:0034220|GO:0098655|GO:0005216|GO:0007215|GO:0030139|GO:0034703|GO:0006812|GO:0032412|GO:2000311|GO:0032281|GO:0008324|GO:0005244|GO:0034704|GO:0022890|GO:0030001|GO:0005261|GO:0007268|GO:0005262|GO:0070588|GO:0022843|GO:0046873|GO:0006816|GO:0015085|GO:0005245 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|transmembrane transporter activity|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|cell periphery|intrinsic component of membrane|channel regulator activity|intracellular|plasma membrane|protein complex|organelle membrane|modulation of synaptic transmission|regulation of membrane potential|transport|plasma membrane protein complex|neurological system process|vesicle|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|vesicle membrane|receptor complex|endocytic vesicle membrane|regulation of signal transduction|substrate-specific transmembrane transporter activity|regulation of cell communication|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|integral component of membrane|regulation of receptor activity|ionotropic glutamate receptor complex|cell surface receptor signaling pathway|membrane depolarization|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|channel activity|ion transport|ion transmembrane transporter activity|voltage-gated calcium channel complex|transmission of nerve impulse|membrane-bounded vesicle|regulation of ion transmembrane transport|ion channel complex|regulation of ion transport|cytoplasmic vesicle membrane|regulation of transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|ion channel activity|glutamate receptor signaling pathway|endocytic vesicle|cation channel complex|cation transport|regulation of ion transmembrane transporter activity|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|AMPA glutamate receptor complex|cation transmembrane transporter activity|voltage-gated ion channel activity|calcium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|synaptic transmission|calcium channel activity|calcium ion transmembrane transport|voltage-gated cation channel activity|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity|voltage-gated calcium channel activity K04869 voltage-dependent calcium channel gamma-4[-] hsa04010|hsa04921|hsa04261|hsa05414|hsa05410|hsa04260|hsa05412 MAPK signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 17:66964910-67033398 171 189 271 959 1095 1204 3.57869895923132 3.5947723424858 5.11343734521008 17.9823129959394 18.802307966914 23.6148079329378 4.0956362156424 20.1331429652637 -2.29741292508945 6.74828132064908e-24 8.1235157478491e-22 DOWN ENSG00000226137 BAIAP2-AS1 BAIAP2 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:44342] - - - - - - 17:81029130-81034881 77 74 102 487 525 596 0.642377197821659 0.5610638464266 0.767208522066702 3.64021904340485 3.59359111415569 4.65989390466424 0.656883188771654 3.96456802074159 -2.59345492938713 7.60149179215906e-24 9.11385284992437e-22 DOWN ENSG00000197971 MBP myelin basic protein [Source:HGNC Symbol;Acc:HGNC:6925] GO:0032502|GO:0002376|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0042995|GO:0043218|GO:0048523|GO:0050794|GO:0043229|GO:0043209|GO:0006955|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0019911|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0045595|GO:0048468|GO:0043025|GO:0007275|GO:0045596|GO:0048513|GO:0048857|GO:0051128|GO:0007420|GO:0043231|GO:0019899|GO:0007267|GO:0060322|GO:0043005|GO:0036477|GO:0030901|GO:0007154|GO:0061024|GO:0009725|GO:0030030|GO:0048869|GO:0010035|GO:0010033|GO:0007568|GO:0009636|GO:0050768|GO:0000902|GO:0031175|GO:0031344|GO:0033993|GO:0030424|GO:0034097|GO:0007417|GO:0010721|GO:0000904|GO:0010038|GO:0021762|GO:0044304|GO:0031345|GO:0002020|GO:0022604|GO:0070542|GO:0046689|GO:0014070|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0033269|GO:0005634|GO:0048545|GO:0051960|GO:0008366|GO:0048666|GO:0030182|GO:0010975|GO:0010769|GO:0032570|GO:0061564|GO:0034612|GO:0042552|GO:0045665|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0010977|GO:0050771|GO:0007409|GO:0048699|GO:0050770|GO:0045664|GO:0007268 developmental process|immune system process|structural molecule activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cell projection|compact myelin|negative regulation of cellular process|regulation of cellular process|intracellular organelle|myelin sheath|immune response|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|structural constituent of myelin sheath|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of cell differentiation|cell development|neuronal cell body|multicellular organism development|negative regulation of cell differentiation|animal organ development|neural nucleus development|regulation of cellular component organization|brain development|intracellular membrane-bounded organelle|enzyme binding|cell-cell signaling|head development|neuron projection|somatodendritic compartment|midbrain development|cell communication|membrane organization|response to hormone|cell projection organization|cellular developmental process|response to inorganic substance|response to organic substance|aging|response to toxic substance|negative regulation of neurogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|response to lipid|axon|response to cytokine|central nervous system development|negative regulation of cell development|cell morphogenesis involved in differentiation|response to metal ion|substantia nigra development|main axon|negative regulation of cell projection organization|protease binding|regulation of cell morphogenesis|response to fatty acid|response to mercury ion|response to organic cyclic compound|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|internode region of axon|nucleus|response to steroid hormone|regulation of nervous system development|axon ensheathment|neuron development|neuron differentiation|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|response to progesterone|axon development|response to tumor necrosis factor|myelination|negative regulation of neuron differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|negative regulation of neuron projection development|negative regulation of axonogenesis|axonogenesis|generation of neurons|regulation of axonogenesis|regulation of neuron differentiation|synaptic transmission - - - - 18:76978827-77133683 102 97 206 818 1127 944 0.173395369624794 0.149861784776324 0.315732497886479 1.24591589340957 1.57191633250784 1.50396700381775 0.212996550762532 1.44059974324505 -2.75776757933011 8.27560281445597e-24 9.88239385691074e-22 DOWN ENSG00000091157 WDR7 WD repeat domain 7 [Source:HGNC Symbol;Acc:HGNC:13490] GO:0032502|GO:0002376|GO:0045202|GO:0005623|GO:0009987|GO:0005488|GO:0008021|GO:0043229|GO:0043227|GO:0005622|GO:0002520|GO:0005515|GO:0012505|GO:0048856|GO:0007275|GO:0048513|GO:0031982|GO:0043231|GO:0030133|GO:0005737|GO:0048869|GO:0030097|GO:0031410|GO:0016023|GO:0070382|GO:0031988|GO:0030154|GO:0002244 developmental process|immune system process|synapse|cell|cellular process|binding|synaptic vesicle|intracellular organelle|membrane-bounded organelle|intracellular|immune system development|protein binding|endomembrane system|anatomical structure development|multicellular organism development|animal organ development|vesicle|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cellular developmental process|hemopoiesis|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|exocytic vesicle|membrane-bounded vesicle|cell differentiation|hematopoietic progenitor cell differentiation - - - - 18:56651343-57036606 25 29 33 240 233 254 0.0706866442212596 0.0745208323987083 0.0841251235796098 0.607997908703492 0.540527615807051 0.673063187642995 0.0764442000665259 0.607196237384513 -2.98968389936246 8.7143719557569e-24 1.03648948353453e-21 DOWN ENSG00000147099 HDAC8 histone deacetylase 8 [Source:HGNC Symbol;Acc:HGNC:13315] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0060341|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0016570|GO:0034641|GO:0032204|GO:0046483|GO:0051128|GO:0043231|GO:0000723|GO:0019213|GO:0043169|GO:0005737|GO:0032880|GO:0016810|GO:0042592|GO:0009890|GO:0006139|GO:0008104|GO:0031647|GO:0051983|GO:0008134|GO:0031072|GO:0007059|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0005829|GO:0000819|GO:0010468|GO:0034645|GO:0046872|GO:0051879|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0016811|GO:0036211|GO:0032269|GO:0000278|GO:0030544|GO:0031981|GO:0007062|GO:0010564|GO:0005654|GO:0006259|GO:0005694|GO:0033558|GO:0000228|GO:0034613|GO:0033043|GO:0044267|GO:0010467|GO:0000118|GO:0051246|GO:0009059|GO:1903827|GO:0016070|GO:0016575|GO:0005634|GO:0033365|GO:0007063|GO:0032200|GO:0045892|GO:0071922|GO:0032774|GO:2001141|GO:0033044|GO:1902679|GO:0006333|GO:0016568|GO:0034979|GO:0070932|GO:0006464|GO:0004407|GO:0006351|GO:0006355|GO:0006366|GO:0034502|GO:1903507|GO:0006357|GO:1903506|GO:0017136|GO:0000122|GO:0032446|GO:0071168|GO:0031396|GO:0031397|GO:0006476|GO:0032041|GO:0016567 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intracellular|protein binding|plasma membrane|protein complex|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|regulation of telomere maintenance|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|telomere maintenance|deacetylase activity|cation binding|cytoplasm|regulation of protein localization|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|homeostatic process|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|protein localization|regulation of protein stability|regulation of chromosome segregation|transcription factor binding|heat shock protein binding|chromosome segregation|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|cytosol|sister chromatid segregation|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|Hsp90 protein binding|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|Hsp70 protein binding|nuclear lumen|sister chromatid cohesion|regulation of cell cycle process|nucleoplasm|DNA metabolic process|chromosome|protein deacetylase activity|nuclear chromosome|cellular protein localization|regulation of organelle organization|cellular protein metabolic process|gene expression|histone deacetylase complex|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of cellular protein localization|RNA metabolic process|histone deacetylation|nucleus|protein localization to organelle|regulation of sister chromatid cohesion|telomere organization|negative regulation of transcription, DNA-templated|regulation of cohesin localization to chromatin|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of chromosome organization|negative regulation of RNA biosynthetic process|chromatin assembly or disassembly|chromatin modification|NAD-dependent protein deacetylase activity|histone H3 deacetylation|cellular protein modification process|histone deacetylase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|protein localization to chromosome|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|NAD-dependent histone deacetylase activity|negative regulation of transcription from RNA polymerase II promoter|protein modification by small protein conjugation|protein localization to chromatin|regulation of protein ubiquitination|negative regulation of protein ubiquitination|protein deacetylation|NAD-dependent histone deacetylase activity (H3-K14 specific)|protein ubiquitination K11405 histone deacetylase 8[3.5.1.98] hsa05203|hsa05034 Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human) X:72329516-72573103 70 47 97 548 549 542 0.472025566179051 0.288039430159593 0.589733476911045 3.31092021932589 3.03745826349974 3.42529905307425 0.449932824416563 3.25789251196663 -2.85615747934188 9.16078356594258e-24 1.08526203403829e-21 DOWN ENSG00000108846 ABCC3 ATP binding cassette subfamily C member 3 [Source:HGNC Symbol;Acc:HGNC:54] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0071704|GO:0043167|GO:0044237|GO:0071944|GO:0016787|GO:0031224|GO:0005886|GO:0006810|GO:1901360|GO:0006082|GO:0043168|GO:0044281|GO:0001882|GO:0016817|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0006629|GO:0000166|GO:0016021|GO:0010876|GO:0016820|GO:0035639|GO:0001883|GO:0016818|GO:0006811|GO:0032549|GO:0015075|GO:0006869|GO:0008202|GO:0017076|GO:0008206|GO:0006820|GO:0015711|GO:0005524|GO:0015721|GO:0008509|GO:0030554|GO:0046942|GO:0019752|GO:0042626|GO:0016462|GO:0015718|GO:0017111|GO:0032787|GO:0008514|GO:0016887|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|organic substance metabolic process|ion binding|cellular metabolic process|cell periphery|hydrolase activity|intrinsic component of membrane|plasma membrane|transport|organic cyclic compound metabolic process|organic acid metabolic process|anion binding|small molecule metabolic process|nucleoside binding|hydrolase activity, acting on acid anhydrides|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|lipid metabolic process|nucleotide binding|integral component of membrane|lipid localization|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|ribonucleoside binding|ion transmembrane transporter activity|lipid transport|steroid metabolic process|purine nucleotide binding|bile acid metabolic process|anion transport|organic anion transport|ATP binding|bile acid and bile salt transport|anion transmembrane transporter activity|adenyl nucleotide binding|carboxylic acid transport|carboxylic acid metabolic process|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|monocarboxylic acid transport|nucleoside-triphosphatase activity|monocarboxylic acid metabolic process|organic anion transmembrane transporter activity|ATPase activity|ATPase activity, coupled|ATPase activity, coupled to movement of substances K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3[-] hsa04976|hsa02010 Bile secretion - Homo sapiens (human)|ABC transporters - Homo sapiens (human) 17:50634777-50692252 522 519 1129 5055 5646 8269 2.53116552259484 2.28716343595386 4.93580465973458 21.9618457642459 22.4625387700816 37.5778484286224 3.25137787276109 27.3340776543166 -3.07157755502337 9.27723086980221e-24 1.09471324263666e-21 DOWN ENSG00000159267 HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) [Source:HGNC Symbol;Acc:HGNC:4976] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0033218|GO:0097159|GO:0008283|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009605|GO:0016874|GO:0005622|GO:0005515|GO:0042802|GO:1901360|GO:0009374|GO:0006082|GO:0009991|GO:0016570|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0043177|GO:0046983|GO:0051186|GO:0019842|GO:0000166|GO:0019538|GO:0010033|GO:0006996|GO:0006790|GO:0007584|GO:0051276|GO:0005829|GO:0006768|GO:0035639|GO:0043412|GO:0006325|GO:0018271|GO:0001883|GO:0036211|GO:0032549|GO:0033273|GO:0071110|GO:0031981|GO:0070781|GO:0005739|GO:0016363|GO:0005694|GO:0014070|GO:0043603|GO:0044267|GO:0031406|GO:0017076|GO:0034399|GO:0031667|GO:0005634|GO:0042803|GO:0005652|GO:0006766|GO:0004078|GO:0005524|GO:0030554|GO:0004079|GO:0004080|GO:0019752|GO:0016568|GO:0006464|GO:0006767|GO:0004077|GO:0009305|GO:0032787 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|amide binding|organic cyclic compound binding|cell proliferation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|response to external stimulus|ligase activity|intracellular|protein binding|identical protein binding|organic cyclic compound metabolic process|biotin binding|organic acid metabolic process|response to extracellular stimulus|histone modification|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|organic acid binding|protein dimerization activity|cofactor metabolic process|vitamin binding|nucleotide binding|protein metabolic process|response to organic substance|organelle organization|sulfur compound metabolic process|response to nutrient|chromosome organization|cytosol|biotin metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|chromatin organization|biotin-protein ligase activity|purine nucleoside binding|protein modification process|ribonucleoside binding|response to vitamin|histone biotinylation|nuclear lumen|response to biotin|mitochondrion|nuclear matrix|chromosome|response to organic cyclic compound|cellular amide metabolic process|cellular protein metabolic process|carboxylic acid binding|purine nucleotide binding|nuclear periphery|response to nutrient levels|nucleus|protein homodimerization activity|nuclear lamina|vitamin metabolic process|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|ATP binding|adenyl nucleotide binding|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|carboxylic acid metabolic process|chromatin modification|cellular protein modification process|water-soluble vitamin metabolic process|biotin-[acetyl-CoA-carboxylase] ligase activity|protein biotinylation|monocarboxylic acid metabolic process K01942 biotin--protein ligase[6.3.4.15] hsa01100|hsa00780 Metabolic pathways - Homo sapiens (human)|Biotin metabolism - Homo sapiens (human) 21:36750888-36990236 51 33 68 362 514 500 0.291286020406028 0.171296842411559 0.35016342665071 1.85249085386594 2.40868760911538 2.67638539984923 0.270915429822766 2.31252128761018 -3.09355217742222 1.24138748718417e-23 1.45907015914946e-21 DOWN ENSG00000153015 CWC27 CWC27 spliceosome-associated protein homolog [Source:HGNC Symbol;Acc:HGNC:10664] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0006457|GO:0043227|GO:0016853|GO:0005622|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0019538|GO:0043412|GO:0036211|GO:0005681|GO:0003755|GO:0044267|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0016071|GO:0006464|GO:0071013|GO:0006397|GO:0018193|GO:0008380|GO:0000375|GO:0018208|GO:0000398|GO:0000413 macromolecular complex|cell|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|protein folding|membrane-bounded organelle|isomerase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|protein metabolic process|macromolecule modification|protein modification process|spliceosomal complex|peptidyl-prolyl cis-trans isomerase activity|cellular protein metabolic process|gene expression|RNA metabolic process|nucleus|RNA processing|mRNA metabolic process|cellular protein modification process|catalytic step 2 spliceosome|mRNA processing|peptidyl-amino acid modification|RNA splicing|RNA splicing, via transesterification reactions|peptidyl-proline modification|mRNA splicing, via spliceosome|protein peptidyl-prolyl isomerization - - - - 5:64768930-65018763 73 67 113 557 611 493 1.10953631468354 0.925500572401273 1.54850730656302 7.58529194565623 7.61954149962825 7.02255316775641 1.19451473121594 7.40912887101363 -2.63287928172923 1.29453110004032e-23 1.51556593963152e-21 DOWN ENSG00000167632 TRAPPC9 trafficking protein particle complex 9 [Source:HGNC Symbol;Acc:HGNC:30832] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0006486|GO:0006725|GO:0051640|GO:0006810|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0030900|GO:0031325|GO:0046483|GO:0007420|GO:0022607|GO:0051668|GO:0043231|GO:0005737|GO:0060322|GO:0021987|GO:0006903|GO:0005975|GO:0051656|GO:0006139|GO:0061024|GO:0005783|GO:0051649|GO:0021543|GO:0048869|GO:0021537|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0006996|GO:0051090|GO:0016192|GO:0051650|GO:0005829|GO:0010468|GO:0034645|GO:0005802|GO:0006900|GO:0016050|GO:0043412|GO:0006487|GO:0090114|GO:0007417|GO:0051252|GO:0010628|GO:0009100|GO:0036211|GO:0046907|GO:0048199|GO:0051091|GO:0070085|GO:0006461|GO:1901137|GO:0044267|GO:0010467|GO:0007399|GO:0000139|GO:0051648|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0010557|GO:0030182|GO:0009101|GO:0045893|GO:0043413|GO:0032774|GO:0048208|GO:2001141|GO:0018279|GO:0051092|GO:0048193|GO:0022008|GO:0006464|GO:0006351|GO:0006355|GO:0048699|GO:1903506|GO:0018193|GO:0043687|GO:0006888 developmental process|cell|membrane|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|protein glycosylation|cellular aromatic compound metabolic process|organelle localization|transport|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|cellular component assembly|localization within membrane|intracellular membrane-bounded organelle|cytoplasm|head development|cerebral cortex development|vesicle targeting|carbohydrate metabolic process|establishment of organelle localization|nucleobase-containing compound metabolic process|membrane organization|endoplasmic reticulum|establishment of localization in cell|pallium development|cellular developmental process|telencephalon development|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|vesicle-mediated transport|establishment of vesicle localization|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|trans-Golgi network|membrane budding|vesicle organization|macromolecule modification|protein N-linked glycosylation|COPII-coated vesicle budding|central nervous system development|regulation of RNA metabolic process|positive regulation of gene expression|glycoprotein metabolic process|protein modification process|intracellular transport|vesicle targeting, to, from or within Golgi|positive regulation of sequence-specific DNA binding transcription factor activity|glycosylation|protein complex assembly|carbohydrate derivative biosynthetic process|cellular protein metabolic process|gene expression|nervous system development|Golgi membrane|vesicle localization|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|neuron differentiation|glycoprotein biosynthetic process|positive regulation of transcription, DNA-templated|macromolecule glycosylation|RNA biosynthetic process|COPII vesicle coating|regulation of RNA biosynthetic process|protein N-linked glycosylation via asparagine|positive regulation of NF-kappaB transcription factor activity|Golgi vesicle transport|neurogenesis|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|generation of neurons|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|post-translational protein modification|ER to Golgi vesicle-mediated transport - - - - 8:139730343-140458579 27 26 57 305 407 464 0.189080842592199 0.165475681027206 0.359889995176919 1.91372010730206 2.33853701522306 3.0452890086658 0.238148839598775 2.43251537706364 -3.35251350081022 1.53305602643607e-23 1.787806820829e-21 DOWN ENSG00000138614 VWA9 von Willebrand factor A domain containing 9 [Source:HGNC Symbol;Acc:HGNC:25372] GO:0005623|GO:0016020|GO:0031224|GO:0005622|GO:0005737|GO:0016021 cell|membrane|intrinsic component of membrane|intracellular|cytoplasm|integral component of membrane - - - - 15:65578753-65611289 117 125 118 795 883 574 0.653779232179023 0.63480078873067 0.594486917651551 3.98025742079267 4.04832022458643 3.00598886056067 0.627688979520415 3.67818883531326 -2.55087376394872 1.62953049062364e-23 1.89291841506141e-21 DOWN ENSG00000104611 SH2D4A SH2 domain containing 4A [Source:HGNC Symbol;Acc:HGNC:26102] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0019222|GO:0019899|GO:0005737|GO:0044092|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0043412|GO:0036211|GO:0032269|GO:0019902|GO:0051346|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0010923|GO:0016311|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0035305|GO:0035303|GO:0035308 cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|regulation of metabolic process|enzyme binding|cytoplasm|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|protein modification process|negative regulation of cellular protein metabolic process|phosphatase binding|negative regulation of hydrolase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|negative regulation of phosphatase activity|dephosphorylation|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation - - - - 8:19313617-19396218 108 107 153 760 831 586 1.30993760342015 1.17948761095993 1.67314957754785 8.25923268619569 8.26984476674876 6.66123327282588 1.38752493064264 7.73010357525678 -2.47797405125694 1.89658131531268e-23 2.19459451888934e-21 DOWN ENSG00000278540 ACACA acetyl-CoA carboxylase alpha [Source:HGNC Symbol;Acc:HGNC:84] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0019222|GO:0044255|GO:0006725|GO:0006810|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0015980|GO:0044281|GO:0001882|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0042592|GO:0051186|GO:0048871|GO:0044236|GO:0006139|GO:0055086|GO:0055085|GO:0006629|GO:0070062|GO:0051649|GO:0009725|GO:0000166|GO:0006091|GO:0044249|GO:0010876|GO:0019538|GO:0010033|GO:0031323|GO:0006790|GO:0055114|GO:0005730|GO:0005829|GO:0006768|GO:0044259|GO:0046486|GO:0046872|GO:0033993|GO:0035639|GO:0004075|GO:0019693|GO:0006637|GO:0015697|GO:0048878|GO:0001894|GO:0006631|GO:0044268|GO:0001883|GO:1903825|GO:0009116|GO:0046907|GO:0006811|GO:0032549|GO:0006638|GO:0031981|GO:0006869|GO:0005739|GO:0006461|GO:0070542|GO:0006112|GO:0006796|GO:0043603|GO:1901137|GO:0008610|GO:0071310|GO:0017076|GO:0032870|GO:0005856|GO:0005634|GO:0034220|GO:0006766|GO:0015936|GO:0015629|GO:0071398|GO:0098655|GO:0006820|GO:0015711|GO:0098656|GO:0003989|GO:0051259|GO:0009259|GO:0009117|GO:0005524|GO:0046390|GO:0006839|GO:0015879|GO:0006812|GO:0015696|GO:0030554|GO:0015908|GO:0009108|GO:0046942|GO:0006633|GO:0034695|GO:0006163|GO:0019752|GO:0055088|GO:0006639|GO:0071379|GO:0009165|GO:0006767|GO:0071396|GO:0042278|GO:0006853|GO:0006084|GO:0015718|GO:0006164|GO:1902603|GO:0072488|GO:0015937|GO:0046949|GO:0032787|GO:0051260|GO:0035336|GO:0051262|GO:0071380|GO:0015672|GO:0006641|GO:0015909|GO:0019432|GO:0051289|GO:0009152|GO:2001295|GO:0035338 cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|ligase activity|intracellular|protein binding|regulation of metabolic process|cellular lipid metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|nucleoside binding|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|homeostatic process|cofactor metabolic process|multicellular organismal homeostasis|multicellular organism metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|transmembrane transport|lipid metabolic process|extracellular exosome|establishment of localization in cell|response to hormone|nucleotide binding|generation of precursor metabolites and energy|cellular biosynthetic process|lipid localization|protein metabolic process|response to organic substance|regulation of cellular metabolic process|sulfur compound metabolic process|oxidation-reduction process|nucleolus|cytosol|biotin metabolic process|multicellular organismal macromolecule metabolic process|glycerolipid metabolic process|metal ion binding|response to lipid|purine ribonucleoside triphosphate binding|biotin carboxylase activity|ribose phosphate metabolic process|acyl-CoA metabolic process|quaternary ammonium group transport|chemical homeostasis|tissue homeostasis|fatty acid metabolic process|multicellular organismal protein metabolic process|purine nucleoside binding|organic acid transmembrane transport|nucleoside metabolic process|intracellular transport|ion transport|ribonucleoside binding|neutral lipid metabolic process|nuclear lumen|lipid transport|mitochondrion|protein complex assembly|response to fatty acid|energy reserve metabolic process|phosphate-containing compound metabolic process|cellular amide metabolic process|carbohydrate derivative biosynthetic process|lipid biosynthetic process|cellular response to organic substance|purine nucleotide binding|cellular response to hormone stimulus|cytoskeleton|nucleus|ion transmembrane transport|vitamin metabolic process|coenzyme A metabolic process|actin cytoskeleton|cellular response to fatty acid|cation transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|acetyl-CoA carboxylase activity|protein oligomerization|ribonucleotide metabolic process|nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|mitochondrial transport|carnitine transport|cation transport|ammonium transport|adenyl nucleotide binding|fatty acid transport|coenzyme biosynthetic process|carboxylic acid transport|fatty acid biosynthetic process|response to prostaglandin E|purine nucleotide metabolic process|carboxylic acid metabolic process|lipid homeostasis|acylglycerol metabolic process|cellular response to prostaglandin stimulus|nucleotide biosynthetic process|water-soluble vitamin metabolic process|cellular response to lipid|purine nucleoside metabolic process|carnitine shuttle|acetyl-CoA metabolic process|monocarboxylic acid transport|purine nucleotide biosynthetic process|carnitine transmembrane transport|ammonium transmembrane transport|coenzyme A biosynthetic process|fatty-acyl-CoA biosynthetic process|monocarboxylic acid metabolic process|protein homooligomerization|long-chain fatty-acyl-CoA metabolic process|protein tetramerization|cellular response to prostaglandin E stimulus|monovalent inorganic cation transport|triglyceride metabolic process|long-chain fatty acid transport|triglyceride biosynthetic process|protein homotetramerization|purine ribonucleotide biosynthetic process|malonyl-CoA biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process - - - - 17:37084988-37406818 310 255 587 2403 2647 3080 0.957906623631165 0.716114470331146 1.6353638245213 6.65293671580265 6.71094910696523 8.91952489343517 1.1031283061612 7.42780357206768 -2.75133506151276 2.14368185876724e-23 2.47094510469642e-21 DOWN ENSG00000135127 CCDC64 coiled-coil domain containing 64 [Source:HGNC Symbol;Acc:HGNC:28095] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0043229|GO:0051641|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0048468|GO:0006810|GO:0007275|GO:0019899|GO:0005737|GO:0051649|GO:0008092|GO:0030030|GO:0048869|GO:0031175|GO:0005813|GO:0005815|GO:0046907|GO:0007399|GO:0051020|GO:0030154|GO:0005856|GO:0034452|GO:0048666|GO:0030182|GO:0055107|GO:0015630|GO:0031267|GO:0022008|GO:0017016|GO:0048699|GO:0017137 developmental process|cell|cellular process|binding|intracellular organelle|cellular localization|cellular component organization|intracellular|protein binding|anatomical structure development|cell development|transport|multicellular organism development|enzyme binding|cytoplasm|establishment of localization in cell|cytoskeletal protein binding|cell projection organization|cellular developmental process|neuron projection development|centrosome|microtubule organizing center|intracellular transport|nervous system development|GTPase binding|cell differentiation|cytoskeleton|dynactin binding|neuron development|neuron differentiation|Golgi to secretory granule transport|microtubule cytoskeleton|small GTPase binding|neurogenesis|Ras GTPase binding|generation of neurons|Rab GTPase binding - - - - 12:119989869-120094494 41 65 95 509 491 619 0.295099891457775 0.425183665018049 0.616478232478982 3.28243752812171 2.89954446662019 4.17541962877359 0.445587262984935 3.4524672078385 -2.95384781231269 2.16908389187131e-23 2.49060886568946e-21 DOWN ENSG00000104889 RNASEH2A ribonuclease H2 subunit A [Source:HGNC Symbol;Acc:HGNC:18518] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0043234|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0032299|GO:0044249|GO:0034645|GO:0046872|GO:0003723|GO:0044265|GO:0031981|GO:0004518|GO:0006298|GO:0005654|GO:0006259|GO:0019439|GO:0009059|GO:0016070|GO:0005634|GO:0006974|GO:0006401|GO:0090501|GO:0006260|GO:0006273|GO:0022616|GO:0043137|GO:0004519|GO:0004540|GO:0090305|GO:0033567|GO:0006271|GO:0006261|GO:0090502|GO:0004521|GO:0016891|GO:0004523 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein complex|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|ribonuclease H2 complex|cellular biosynthetic process|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|cellular macromolecule catabolic process|nuclear lumen|nuclease activity|mismatch repair|nucleoplasm|DNA metabolic process|aromatic compound catabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|RNA catabolic process|RNA phosphodiester bond hydrolysis|DNA replication|lagging strand elongation|DNA strand elongation|DNA replication, removal of RNA primer|endonuclease activity|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|DNA replication, Okazaki fragment processing|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|endoribonuclease activity, producing 5'-phosphomonoesters|RNA-DNA hybrid ribonuclease activity K10743 ribonuclease H2 subunit A[3.1.26.4] hsa03030 DNA replication - Homo sapiens (human) 19:12806580-12813638 152 157 232 1019 1127 793 3.00924479588924 2.82483539072818 4.14108804173387 18.0752703180132 18.3064680973926 14.7134689781887 3.3250560761171 17.0317357978648 -2.35677489892573 2.36627163170248e-23 2.70661583497493e-21 DOWN ENSG00000100503 NIN ninein [Source:HGNC Symbol;Acc:HGNC:14906] GO:0005623|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0051640|GO:0043168|GO:0005874|GO:0001882|GO:0043231|GO:0043169|GO:0005737|GO:0000166|GO:0007017|GO:0006996|GO:0005730|GO:0005813|GO:0046872|GO:0035639|GO:0007010|GO:0005815|GO:0001883|GO:0032549|GO:0031981|GO:0051642|GO:0017076|GO:0000226|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0034453|GO:0032561|GO:0005509|GO:0015630|GO:0005525|GO:0000242|GO:0019001|GO:0072393|GO:0034454 cell|cellular process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|organelle localization|anion binding|microtubule|nucleoside binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleotide binding|microtubule-based process|organelle organization|nucleolus|centrosome|metal ion binding|purine ribonucleoside triphosphate binding|cytoskeleton organization|microtubule organizing center|purine nucleoside binding|ribonucleoside binding|nuclear lumen|centrosome localization|purine nucleotide binding|microtubule cytoskeleton organization|cytoskeleton|spindle pole|nucleus|spindle|microtubule anchoring|guanyl ribonucleotide binding|calcium ion binding|microtubule cytoskeleton|GTP binding|pericentriolar material|guanyl nucleotide binding|microtubule anchoring at microtubule organizing center|microtubule anchoring at centrosome - - - - 14:50719763-50831121 423 515 783 2711 3008 2803 1.29268249611073 1.43033615567368 2.15738165293683 7.42297873240328 7.54217847600837 8.02792091148429 1.62680010157375 7.66435937329865 -2.2361282230369 2.77140640277046e-23 3.15792239497364e-21 DOWN ENSG00000184903 IMMP2L inner mitochondrial membrane peptidase subunit 2 [Source:HGNC Symbol;Acc:HGNC:14598] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0042698|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0016043|GO:0043227|GO:0032504|GO:0016787|GO:0031224|GO:0005622|GO:0022602|GO:0043234|GO:0048856|GO:0031090|GO:0048609|GO:0045137|GO:0019866|GO:0006810|GO:0007275|GO:0048513|GO:0034641|GO:0015980|GO:0033554|GO:0007420|GO:0022607|GO:0043231|GO:0048608|GO:0001541|GO:0008233|GO:0005737|GO:0060322|GO:0072593|GO:0030728|GO:0007548|GO:0031966|GO:0045184|GO:0008104|GO:0008406|GO:0007276|GO:0051649|GO:0006091|GO:0016021|GO:0022900|GO:0019538|GO:0003013|GO:0006996|GO:0055114|GO:0017171|GO:0005740|GO:0006518|GO:0048232|GO:0001944|GO:0008585|GO:0072594|GO:0061458|GO:0072358|GO:0007417|GO:0007005|GO:0051604|GO:0015031|GO:0046545|GO:0046907|GO:0022904|GO:0005743|GO:0006508|GO:0005739|GO:0006461|GO:0034613|GO:0008236|GO:0043603|GO:0044267|GO:0010467|GO:0042720|GO:0007399|GO:0045333|GO:0006626|GO:0072359|GO:0007292|GO:0008015|GO:0006974|GO:0006801|GO:0006627|GO:0007283|GO:0004252|GO:0033365|GO:0034622|GO:0016485|GO:0006839|GO:0043623|GO:0006605|GO:0072655|GO:0006886|GO:0004175|GO:0061300|GO:0006465|GO:0033108|GO:0034982|GO:0070585 developmental process|macromolecular complex|reproduction|cell|rhythmic process|membrane|cellular process|reproductive process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ovulation cycle|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|hydrolase activity|intrinsic component of membrane|intracellular|ovulation cycle process|protein complex|anatomical structure development|organelle membrane|multicellular organismal reproductive process|development of primary sexual characteristics|organelle inner membrane|transport|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|cellular response to stress|brain development|cellular component assembly|intracellular membrane-bounded organelle|reproductive structure development|ovarian follicle development|peptidase activity|cytoplasm|head development|reactive oxygen species metabolic process|ovulation|sex differentiation|mitochondrial membrane|establishment of protein localization|protein localization|gonad development|gamete generation|establishment of localization in cell|generation of precursor metabolites and energy|integral component of membrane|electron transport chain|protein metabolic process|circulatory system process|organelle organization|oxidation-reduction process|serine hydrolase activity|mitochondrial envelope|peptide metabolic process|male gamete generation|vasculature development|female gonad development|establishment of protein localization to organelle|reproductive system development|cardiovascular system development|central nervous system development|mitochondrion organization|protein maturation|protein transport|development of primary female sexual characteristics|intracellular transport|respiratory electron transport chain|mitochondrial inner membrane|proteolysis|mitochondrion|protein complex assembly|cellular protein localization|serine-type peptidase activity|cellular amide metabolic process|cellular protein metabolic process|gene expression|mitochondrial inner membrane peptidase complex|nervous system development|cellular respiration|protein targeting to mitochondrion|circulatory system development|female gamete generation|blood circulation|cellular response to DNA damage stimulus|superoxide metabolic process|protein processing involved in protein targeting to mitochondrion|spermatogenesis|serine-type endopeptidase activity|protein localization to organelle|cellular macromolecular complex assembly|protein processing|mitochondrial transport|cellular protein complex assembly|protein targeting|establishment of protein localization to mitochondrion|intracellular protein transport|endopeptidase activity|cerebellum vasculature development|signal peptide processing|mitochondrial respiratory chain complex assembly|mitochondrial protein processing|protein localization to mitochondrion K09648 mitochondrial inner membrane protease subunit 2 [EC:3.4.21.-][-] hsa03060 Protein export - Homo sapiens (human) 7:110663051-111562517 8 10 7 111 121 116 0.0909756436632348 0.103355791123906 0.0717705771382838 1.13103701376471 1.12903990796819 1.2363559000516 0.0887006706418082 1.1654776072615 -3.71583246309646 3.61567335087064e-23 4.1042704264978e-21 DOWN ENSG00000099256 PRTFDC1 phosphoribosyl transferase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23333] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0042802|GO:0006725|GO:1901360|GO:0034641|GO:0044281|GO:0046483|GO:0043169|GO:0005737|GO:0046983|GO:0006139|GO:0055086|GO:0016757|GO:0000166|GO:0044249|GO:0005829|GO:0046872|GO:0009116|GO:1901137|GO:0016763|GO:0042803|GO:0043101|GO:0000287|GO:0042278|GO:0004422|GO:0006166 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|cation binding|cytoplasm|protein dimerization activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|transferase activity, transferring glycosyl groups|nucleotide binding|cellular biosynthetic process|cytosol|metal ion binding|nucleoside metabolic process|carbohydrate derivative biosynthetic process|transferase activity, transferring pentosyl groups|protein homodimerization activity|purine-containing compound salvage|magnesium ion binding|purine nucleoside metabolic process|hypoxanthine phosphoribosyltransferase activity|purine ribonucleoside salvage - - - - 10:24848607-24952604 121 141 182 832 968 657 3.24703786528673 3.43874810994183 4.40336560001258 20.0042010845786 21.3129619496009 16.5232302806116 3.69638385841371 19.2801311049304 -2.38292837271691 4.19064245350056e-23 4.72933708348624e-21 DOWN ENSG00000150760 DOCK1 dedicator of cytokinesis 1 [Source:HGNC Symbol;Acc:HGNC:2987] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0006955|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005085|GO:0048856|GO:0019222|GO:0002757|GO:0050817|GO:0006935|GO:0045087|GO:0048468|GO:0006810|GO:0007275|GO:0048513|GO:0008047|GO:0006952|GO:0043231|GO:0005737|GO:0009611|GO:0006928|GO:0019904|GO:0043085|GO:0050776|GO:0007154|GO:0061024|GO:0016477|GO:0007165|GO:0050778|GO:0008219|GO:0050790|GO:0030030|GO:0048869|GO:0050878|GO:0006996|GO:0016192|GO:0000902|GO:0006909|GO:0005829|GO:0031175|GO:0005096|GO:0007166|GO:0007010|GO:0030097|GO:0051345|GO:0007596|GO:0030695|GO:0017124|GO:0000904|GO:0042060|GO:0002429|GO:0031981|GO:0007599|GO:0010324|GO:0005654|GO:0002764|GO:0012501|GO:0035556|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0005634|GO:0038096|GO:0048666|GO:0030182|GO:0007411|GO:0043087|GO:0007229|GO:0002768|GO:0061564|GO:0043547|GO:0007167|GO:0006911|GO:0002244|GO:0002431|GO:0006897|GO:0022008|GO:0048667|GO:0007264|GO:0048812|GO:0006915|GO:0007409|GO:0048699|GO:0038093|GO:0007169|GO:0048010|GO:0038094 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|immune response|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|immune system development|protein binding|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|immune response-activating signal transduction|coagulation|chemotaxis|innate immune response|cell development|transport|multicellular organism development|animal organ development|enzyme activator activity|defense response|intracellular membrane-bounded organelle|cytoplasm|response to wounding|movement of cell or subcellular component|protein domain specific binding|positive regulation of catalytic activity|regulation of immune response|cell communication|membrane organization|cell migration|signal transduction|positive regulation of immune response|cell death|regulation of catalytic activity|cell projection organization|cellular developmental process|regulation of body fluid levels|organelle organization|vesicle-mediated transport|cell morphogenesis|phagocytosis|cytosol|neuron projection development|GTPase activator activity|cell surface receptor signaling pathway|cytoskeleton organization|hemopoiesis|positive regulation of hydrolase activity|blood coagulation|GTPase regulator activity|SH3 domain binding|cell morphogenesis involved in differentiation|wound healing|immune response-activating cell surface receptor signaling pathway|nuclear lumen|hemostasis|membrane invagination|nucleoplasm|immune response-regulating signaling pathway|programmed cell death|intracellular signal transduction|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|nucleus|Fc-gamma receptor signaling pathway involved in phagocytosis|neuron development|neuron differentiation|axon guidance|regulation of GTPase activity|integrin-mediated signaling pathway|immune response-regulating cell surface receptor signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|phagocytosis, engulfment|hematopoietic progenitor cell differentiation|Fc receptor mediated stimulatory signaling pathway|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|neuron projection morphogenesis|apoptotic process|axonogenesis|generation of neurons|Fc receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-gamma receptor signaling pathway K13708 dedicator of cytokinesis protein 1[-] hsa04810|hsa04510|hsa05100|hsa05131 Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Shigellosis - Homo sapiens (human) 10:126905409-127452517 67 57 146 693 825 1037 0.533173656299719 0.412240594348614 1.04751137339467 4.94109844510669 5.38659821767021 7.73393193837807 0.664308541347668 6.02054286705166 -3.17996821029105 4.19801141262093e-23 4.72933708348624e-21 DOWN ENSG00000082068 WDR70 WD repeat domain 70 [Source:HGNC Symbol;Acc:HGNC:25495] GO:0005488|GO:0005515|GO:0019899 binding|protein binding|enzyme binding - - - - 5:37379212-37753435 77 52 91 553 578 458 0.622268509120285 0.381919308592667 0.66304533997676 4.00416146517271 3.83252294389025 3.46883117645568 0.555744385896571 3.76850519517288 -2.76149900714012 4.6145220436042e-23 5.1790203417203e-21 DOWN ENSG00000174628 IQCK IQ motif containing K [Source:HGNC Symbol;Acc:HGNC:28556] - - - - - - 16:19716456-19858467 16 18 29 270 230 181 0.125923817102752 0.128746265845934 0.205777718483291 1.90389999331742 1.48517894201788 1.33502456220799 0.153482600477326 1.57470116584776 -3.35893105234 5.0305868795912e-23 5.62483673046127e-21 DOWN ENSG00000128059 PPAT phosphoribosyl pyrophosphate amidotransferase [Source:HGNC Symbol;Acc:HGNC:9238] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0006807|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0032504|GO:0009058|GO:0005622|GO:0016740|GO:0048856|GO:0048609|GO:0007049|GO:0006725|GO:0001822|GO:0006810|GO:0022402|GO:1901360|GO:0006082|GO:0051536|GO:0007275|GO:0048513|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0022607|GO:0043169|GO:0010243|GO:0005737|GO:0006520|GO:0060135|GO:0042493|GO:0006139|GO:0055086|GO:0007565|GO:0016757|GO:0009725|GO:0044249|GO:0010033|GO:0048732|GO:0050878|GO:0005829|GO:0030879|GO:0051539|GO:0046872|GO:1903047|GO:0007589|GO:0001655|GO:0019693|GO:0031100|GO:0044770|GO:1901652|GO:0071417|GO:0000278|GO:0009116|GO:0072001|GO:0009063|GO:0043434|GO:0006461|GO:0007595|GO:0006796|GO:1901137|GO:0046903|GO:0016763|GO:0071310|GO:0035690|GO:0032870|GO:0009124|GO:0051259|GO:0009259|GO:1901653|GO:0004044|GO:0009117|GO:0044772|GO:0046390|GO:0009113|GO:0046395|GO:0071375|GO:0006163|GO:0006144|GO:0019752|GO:0032868|GO:0009165|GO:0006541|GO:0006164|GO:0032869|GO:0000082|GO:0051260|GO:0051262|GO:0009156|GO:0006543|GO:0051289|GO:0009152|GO:0046040|GO:0009168|GO:0006188|GO:0006189 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|multicellular organism reproduction|biosynthetic process|intracellular|transferase activity|anatomical structure development|multicellular organismal reproductive process|cell cycle|cellular aromatic compound metabolic process|kidney development|transport|cell cycle process|organic cyclic compound metabolic process|organic acid metabolic process|iron-sulfur cluster binding|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|cellular component assembly|cation binding|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|maternal process involved in female pregnancy|response to drug|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|female pregnancy|transferase activity, transferring glycosyl groups|response to hormone|cellular biosynthetic process|response to organic substance|gland development|regulation of body fluid levels|cytosol|mammary gland development|4 iron, 4 sulfur cluster binding|metal ion binding|mitotic cell cycle process|body fluid secretion|urogenital system development|ribose phosphate metabolic process|organ regeneration|cell cycle phase transition|response to peptide|cellular response to organonitrogen compound|mitotic cell cycle|nucleoside metabolic process|renal system development|cellular amino acid catabolic process|response to peptide hormone|protein complex assembly|lactation|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|secretion|transferase activity, transferring pentosyl groups|cellular response to organic substance|cellular response to drug|cellular response to hormone stimulus|nucleoside monophosphate biosynthetic process|protein oligomerization|ribonucleotide metabolic process|cellular response to peptide|amidophosphoribosyltransferase activity|nucleotide metabolic process|mitotic cell cycle phase transition|ribose phosphate biosynthetic process|purine nucleobase biosynthetic process|carboxylic acid catabolic process|cellular response to peptide hormone stimulus|purine nucleotide metabolic process|purine nucleobase metabolic process|carboxylic acid metabolic process|response to insulin|nucleotide biosynthetic process|glutamine metabolic process|purine nucleotide biosynthetic process|cellular response to insulin stimulus|G1/S transition of mitotic cell cycle|protein homooligomerization|protein tetramerization|ribonucleoside monophosphate biosynthetic process|glutamine catabolic process|protein homotetramerization|purine ribonucleotide biosynthetic process|IMP metabolic process|purine ribonucleoside monophosphate biosynthetic process|IMP biosynthetic process|'de novo' IMP biosynthetic process K00764 amidophosphoribosyltransferase[2.4.2.14] hsa01100|hsa00230|hsa00250 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human) 4:56393362-56435615 135 167 189 801 1049 726 1.09386731891983 1.2297834904768 1.38072754407641 5.81516194793303 6.97388944859884 5.51311747820823 1.23479278449101 6.1007229582467 -2.30471125980251 5.4182116752202e-23 6.03564519970239e-21 DOWN ENSG00000176105 YES1 YES proto-oncogene 1, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:12841] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0019898|GO:0097159|GO:0030055|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0050900|GO:0043167|GO:0006955|GO:0044237|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:0002757|GO:0042127|GO:0036119|GO:0050817|GO:0016337|GO:0009898|GO:0006935|GO:0045087|GO:0006725|GO:0048468|GO:0050867|GO:0044325|GO:0006810|GO:1901360|GO:0005884|GO:0007275|GO:0070489|GO:0005102|GO:0034641|GO:0043168|GO:0005924|GO:0006952|GO:0030155|GO:0005912|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:0098609|GO:0043231|GO:0019899|GO:0005737|GO:0009611|GO:0071559|GO:0006928|GO:0031234|GO:0002696|GO:0001775|GO:0098562|GO:0019897|GO:0006139|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0016477|GO:0007165|GO:0050778|GO:0070062|GO:0045785|GO:0043114|GO:0031295|GO:0000166|GO:0030030|GO:0048869|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0050878|GO:0003013|GO:0005794|GO:0016192|GO:0051249|GO:0032268|GO:0000902|GO:0006909|GO:0005829|GO:0031175|GO:0010468|GO:0034645|GO:0007166|GO:0070851|GO:0033993|GO:0035639|GO:0036120|GO:0043412|GO:0007596|GO:0051252|GO:0005815|GO:0001883|GO:0034109|GO:0000904|GO:0010628|GO:0036211|GO:0071560|GO:0042060|GO:0032549|GO:0051251|GO:0002429|GO:0022407|GO:0007599|GO:0007159|GO:0051247|GO:0070848|GO:0002764|GO:0016301|GO:0032270|GO:0042110|GO:0006796|GO:0032526|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0017076|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0022409|GO:0048858|GO:0016070|GO:0008643|GO:0016773|GO:0008015|GO:0005856|GO:0010557|GO:0038096|GO:0005925|GO:0048666|GO:0030182|GO:0015629|GO:0007411|GO:0045893|GO:0031401|GO:0050863|GO:0005154|GO:0032774|GO:0005524|GO:2001141|GO:0071363|GO:0030554|GO:0016310|GO:0002768|GO:0034112|GO:0070486|GO:0061564|GO:0007167|GO:0015630|GO:0004672|GO:0002431|GO:0071300|GO:0006897|GO:0022008|GO:0048667|GO:0006464|GO:0050870|GO:0048812|GO:0071396|GO:0006351|GO:0006355|GO:1903039|GO:0045944|GO:0006366|GO:0008645|GO:0006357|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0042325|GO:0004713|GO:0001932|GO:0018193|GO:0038093|GO:0001934|GO:0071593|GO:0042327|GO:0007169|GO:0004715|GO:0050731|GO:0038094|GO:0050730|GO:0015758|GO:0048013|GO:0046777|GO:0018108|GO:0038083 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|organic cyclic compound binding|cell-substrate junction|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|leukocyte migration|ion binding|immune response|cellular metabolic process|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|immune response-activating signal transduction|regulation of cell proliferation|response to platelet-derived growth factor|coagulation|single organismal cell-cell adhesion|cytoplasmic side of plasma membrane|chemotaxis|innate immune response|cellular aromatic compound metabolic process|cell development|positive regulation of cell activation|ion channel binding|transport|organic cyclic compound metabolic process|actin filament|multicellular organism development|T cell aggregation|receptor binding|cellular nitrogen compound metabolic process|anion binding|cell-substrate adherens junction|defense response|regulation of cell adhesion|adherens junction|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cell-cell adhesion|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|response to wounding|response to transforming growth factor beta|movement of cell or subcellular component|extrinsic component of cytoplasmic side of plasma membrane|positive regulation of leukocyte activation|cell activation|cytoplasmic side of membrane|extrinsic component of plasma membrane|nucleobase-containing compound metabolic process|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|cell migration|signal transduction|positive regulation of immune response|extracellular exosome|positive regulation of cell adhesion|regulation of vascular permeability|T cell costimulation|nucleotide binding|cell projection organization|cellular developmental process|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|Golgi apparatus|vesicle-mediated transport|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cell morphogenesis|phagocytosis|cytosol|neuron projection development|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|growth factor receptor binding|response to lipid|purine ribonucleoside triphosphate binding|cellular response to platelet-derived growth factor stimulus|macromolecule modification|blood coagulation|regulation of RNA metabolic process|microtubule organizing center|purine nucleoside binding|homotypic cell-cell adhesion|cell morphogenesis involved in differentiation|positive regulation of gene expression|protein modification process|cellular response to transforming growth factor beta stimulus|wound healing|ribonucleoside binding|positive regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|regulation of cell-cell adhesion|hemostasis|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|kinase activity|positive regulation of cellular protein metabolic process|T cell activation|phosphate-containing compound metabolic process|response to retinoic acid|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|cell projection morphogenesis|RNA metabolic process|carbohydrate transport|phosphotransferase activity, alcohol group as acceptor|blood circulation|cytoskeleton|positive regulation of macromolecule biosynthetic process|Fc-gamma receptor signaling pathway involved in phagocytosis|focal adhesion|neuron development|neuron differentiation|actin cytoskeleton|axon guidance|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|regulation of T cell activation|epidermal growth factor receptor binding|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|immune response-regulating cell surface receptor signaling pathway|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|axon development|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|protein kinase activity|Fc receptor mediated stimulatory signaling pathway|cellular response to retinoic acid|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|positive regulation of T cell activation|neuron projection morphogenesis|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of leukocyte cell-cell adhesion|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|hexose transport|regulation of transcription from RNA polymerase II promoter|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of phosphorylation|protein tyrosine kinase activity|regulation of protein phosphorylation|peptidyl-amino acid modification|Fc receptor signaling pathway|positive regulation of protein phosphorylation|lymphocyte aggregation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|non-membrane spanning protein tyrosine kinase activity|positive regulation of peptidyl-tyrosine phosphorylation|Fc-gamma receptor signaling pathway|regulation of peptidyl-tyrosine phosphorylation|glucose transport|ephrin receptor signaling pathway|protein autophosphorylation|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation K05705 tyrosine-protein kinase Yes[2.7.10.2] hsa04530|hsa04520 Tight junction - Homo sapiens (human)|Adherens junction - Homo sapiens (human) 18:721588-812546 327 388 368 1526 1814 1511 2.72033028221884 2.9334980660937 2.76016963420051 11.3743280076697 12.3816587020051 11.7805848814893 2.80466599417102 11.8455238637214 -2.07844112604793 5.86583668761239e-23 6.50998841903273e-21 DOWN ENSG00000139687 RB1 retinoblastoma 1 [Source:HGNC Symbol;Acc:HGNC:9884] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0023051|GO:0000989|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0002262|GO:0023057|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042802|GO:0016032|GO:0051219|GO:0060341|GO:0051726|GO:0042127|GO:0007049|GO:1903706|GO:0048565|GO:0045595|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0090230|GO:0007275|GO:0003676|GO:0009410|GO:0048513|GO:0034101|GO:0051302|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0070603|GO:0061061|GO:0045786|GO:0045597|GO:0043231|GO:0019899|GO:0032880|GO:0005667|GO:0042592|GO:0009966|GO:0050673|GO:0009890|GO:0045787|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0044092|GO:0006629|GO:0007165|GO:0009968|GO:0051983|GO:0008134|GO:0009725|GO:0008219|GO:0008285|GO:0050790|GO:0007059|GO:0030030|GO:0051781|GO:0051301|GO:0043086|GO:0048869|GO:0051984|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0051090|GO:0003713|GO:0051276|GO:0032268|GO:0000902|GO:0045732|GO:0031175|GO:0003677|GO:0000819|GO:0010468|GO:0000075|GO:0034645|GO:0030218|GO:0090068|GO:0055123|GO:0007166|GO:0033993|GO:1903047|GO:0044798|GO:0043412|GO:0030097|GO:0030163|GO:0001085|GO:0010629|GO:0051304|GO:0051427|GO:0042692|GO:0051252|GO:0006325|GO:0070997|GO:0044770|GO:0044265|GO:0008589|GO:0007050|GO:0000904|GO:0045879|GO:0010628|GO:0036211|GO:0032269|GO:0000278|GO:0060537|GO:0048872|GO:0071466|GO:0031981|GO:0007062|GO:0007346|GO:0010564|GO:0051247|GO:0045930|GO:0006508|GO:0005654|GO:0043433|GO:0050678|GO:0005694|GO:0050680|GO:0034613|GO:0019900|GO:0032270|GO:0012501|GO:0014070|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0042176|GO:0007067|GO:0010467|GO:0045639|GO:0007399|GO:0019216|GO:0071310|GO:1901970|GO:0090544|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0009755|GO:0007517|GO:0048469|GO:1903827|GO:0016070|GO:0045931|GO:0008608|GO:0033613|GO:0032870|GO:0005856|GO:0010557|GO:0005634|GO:0005819|GO:0048545|GO:0030522|GO:0045637|GO:0010948|GO:0044389|GO:0010638|GO:0048666|GO:2001252|GO:0030182|GO:0043401|GO:0000083|GO:0031625|GO:0002521|GO:0002761|GO:0060538|GO:0044257|GO:0000975|GO:0045893|GO:0001102|GO:0042551|GO:0033365|GO:0007063|GO:0045445|GO:0034622|GO:0010498|GO:0045892|GO:0007093|GO:0071922|GO:0007088|GO:0032774|GO:1903364|GO:0044772|GO:0043550|GO:0030162|GO:2001141|GO:0035257|GO:0007224|GO:0007064|GO:0045862|GO:0016310|GO:0033044|GO:1902679|GO:0071383|GO:0071407|GO:0016604|GO:0030518|GO:0034508|GO:1901990|GO:1901989|GO:0051603|GO:0031134|GO:0015630|GO:1901992|GO:0002763|GO:0065004|GO:0000070|GO:0035914|GO:0051146|GO:0045840|GO:0051306|GO:0016568|GO:0033673|GO:1901987|GO:0051402|GO:0090575|GO:0045842|GO:0007091|GO:0030099|GO:0014706|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0071396|GO:0016514|GO:0034088|GO:0043549|GO:0006351|GO:0043353|GO:0006915|GO:0006355|GO:1901991|GO:0030071|GO:0045944|GO:2000045|GO:0006366|GO:0007265|GO:0034502|GO:0002573|GO:0045859|GO:1903507|GO:1903052|GO:0035258|GO:0006469|GO:0006357|GO:0010965|GO:0019941|GO:0006468|GO:0048699|GO:0007519|GO:1903506|GO:0044212|GO:1901800|GO:0042325|GO:0035189|GO:0001932|GO:0007070|GO:1902806|GO:0042326|GO:0030521|GO:0016605|GO:2000134|GO:0000082|GO:0071930|GO:0006338|GO:0001933|GO:0000122|GO:0034349|GO:0045651|GO:0061136|GO:1902807|GO:0043161|GO:0071168|GO:0006511|GO:0050681|GO:0030225|GO:0001047|GO:0097284|GO:0032434|GO:0032436|GO:0071459 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|myeloid cell homeostasis|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|identical protein binding|viral process|phosphoprotein binding|regulation of cellular localization|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of hemopoiesis|digestive tract development|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of centromere complex assembly|multicellular organism development|nucleic acid binding|response to xenobiotic stimulus|animal organ development|erythrocyte homeostasis|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|SWI/SNF superfamily-type complex|muscle structure development|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|regulation of protein localization|transcription factor complex|homeostatic process|regulation of signal transduction|epithelial cell proliferation|negative regulation of biosynthetic process|positive regulation of cell cycle|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|negative regulation of molecular function|lipid metabolic process|signal transduction|negative regulation of signal transduction|regulation of chromosome segregation|transcription factor binding|response to hormone|cell death|negative regulation of cell proliferation|regulation of catalytic activity|chromosome segregation|cell projection organization|positive regulation of cell division|cell division|negative regulation of catalytic activity|cellular developmental process|positive regulation of chromosome segregation|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|transcription coactivator activity|chromosome organization|regulation of cellular protein metabolic process|cell morphogenesis|positive regulation of protein catabolic process|neuron projection development|DNA binding|sister chromatid segregation|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|erythrocyte differentiation|positive regulation of cell cycle process|digestive system development|cell surface receptor signaling pathway|response to lipid|mitotic cell cycle process|nuclear transcription factor complex|macromolecule modification|hemopoiesis|protein catabolic process|RNA polymerase II transcription factor binding|negative regulation of gene expression|chromosome separation|hormone receptor binding|muscle cell differentiation|regulation of RNA metabolic process|chromatin organization|neuron death|cell cycle phase transition|cellular macromolecule catabolic process|regulation of smoothened signaling pathway|cell cycle arrest|cell morphogenesis involved in differentiation|negative regulation of smoothened signaling pathway|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|muscle tissue development|homeostasis of number of cells|cellular response to xenobiotic stimulus|nuclear lumen|sister chromatid cohesion|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|proteolysis|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of epithelial cell proliferation|chromosome|negative regulation of epithelial cell proliferation|cellular protein localization|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|mitotic nuclear division|gene expression|positive regulation of myeloid cell differentiation|nervous system development|regulation of lipid metabolic process|cellular response to organic substance|positive regulation of mitotic sister chromatid separation|BAF-type complex|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|muscle organ development|cell maturation|regulation of cellular protein localization|RNA metabolic process|positive regulation of mitotic cell cycle|attachment of spindle microtubules to kinetochore|activating transcription factor binding|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|spindle|response to steroid hormone|intracellular receptor signaling pathway|regulation of myeloid cell differentiation|negative regulation of cell cycle process|ubiquitin-like protein ligase binding|positive regulation of organelle organization|neuron development|positive regulation of chromosome organization|neuron differentiation|steroid hormone mediated signaling pathway|regulation of transcription involved in G1/S transition of mitotic cell cycle|ubiquitin protein ligase binding|leukocyte differentiation|regulation of myeloid leukocyte differentiation|skeletal muscle organ development|cellular protein catabolic process|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA polymerase II activating transcription factor binding|neuron maturation|protein localization to organelle|regulation of sister chromatid cohesion|myoblast differentiation|cellular macromolecular complex assembly|proteasomal protein catabolic process|negative regulation of transcription, DNA-templated|mitotic cell cycle checkpoint|regulation of cohesin localization to chromatin|regulation of mitotic nuclear division|RNA biosynthetic process|positive regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of lipid kinase activity|regulation of proteolysis|regulation of RNA biosynthetic process|nuclear hormone receptor binding|smoothened signaling pathway|mitotic sister chromatid cohesion|positive regulation of proteolysis|phosphorylation|regulation of chromosome organization|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|nuclear body|intracellular steroid hormone receptor signaling pathway|centromere complex assembly|regulation of mitotic cell cycle phase transition|positive regulation of cell cycle phase transition|proteolysis involved in cellular protein catabolic process|sister chromatid biorientation|microtubule cytoskeleton|positive regulation of mitotic cell cycle phase transition|positive regulation of myeloid leukocyte differentiation|protein-DNA complex assembly|mitotic sister chromatid segregation|skeletal muscle cell differentiation|striated muscle cell differentiation|positive regulation of mitotic nuclear division|mitotic sister chromatid separation|chromatin modification|negative regulation of kinase activity|regulation of cell cycle phase transition|neuron apoptotic process|RNA polymerase II transcription factor complex|positive regulation of mitotic metaphase/anaphase transition|metaphase/anaphase transition of mitotic cell cycle|myeloid cell differentiation|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|cellular response to lipid|SWI/SNF complex|maintenance of mitotic sister chromatid cohesion|regulation of kinase activity|transcription, DNA-templated|enucleate erythrocyte differentiation|apoptotic process|regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle phase transition|regulation of mitotic metaphase/anaphase transition|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|Ras protein signal transduction|protein localization to chromosome|myeloid leukocyte differentiation|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of proteolysis involved in cellular protein catabolic process|steroid hormone receptor binding|negative regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|regulation of mitotic sister chromatid separation|modification-dependent protein catabolic process|protein phosphorylation|generation of neurons|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|positive regulation of proteasomal protein catabolic process|regulation of phosphorylation|Rb-E2F complex|regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter during mitosis|regulation of cell cycle G1/S phase transition|negative regulation of phosphorylation|androgen receptor signaling pathway|PML body|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|chromatin remodeling|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|glial cell apoptotic process|positive regulation of macrophage differentiation|regulation of proteasomal protein catabolic process|negative regulation of cell cycle G1/S phase transition|proteasome-mediated ubiquitin-dependent protein catabolic process|protein localization to chromatin|ubiquitin-dependent protein catabolic process|androgen receptor binding|macrophage differentiation|core promoter binding|hepatocyte apoptotic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein localization to chromosome, centromeric region K06618 retinoblastoma-associated protein[-] hsa05200|hsa05166|hsa05203|hsa05169|hsa05161|hsa04110|hsa05215|hsa05222|hsa05220|hsa05218|hsa05212|hsa05214|hsa05223|hsa05219 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Melanoma - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Glioma - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Bladder cancer - Homo sapiens (human) 13:48303751-48481986 116 132 307 1381 1513 1339 1.03032281111006 1.06553539357574 2.45848334383953 10.9902029072299 11.0260884248645 11.1461269095088 1.51811384950844 11.0541394138677 -2.86423481945724 6.30199579106118e-23 6.9424273928539e-21 DOWN ENSG00000144283 PKP4 plakophilin 4 [Source:HGNC Symbol;Acc:HGNC:9026] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0030496|GO:0050794|GO:0060076|GO:0043229|GO:0005911|GO:0016043|GO:0007155|GO:0071944|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0051726|GO:0007049|GO:0016337|GO:0009898|GO:0022402|GO:0051302|GO:0044291|GO:0030155|GO:0022607|GO:0098609|GO:0005737|GO:0007267|GO:0098562|GO:0045787|GO:0014069|GO:0043085|GO:0007154|GO:0030057|GO:0050790|GO:0051781|GO:0051301|GO:0032467|GO:0045216|GO:0090068|GO:0051345|GO:0051233|GO:0034329|GO:0032465|GO:0010564|GO:0048471|GO:0005856|GO:0000910|GO:0000922|GO:0005819|GO:0072686|GO:0043087|GO:0043547|GO:0015630|GO:0007043 synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|binding|midbody|regulation of cellular process|excitatory synapse|intracellular organelle|cell-cell junction|cellular component organization|cell adhesion|cell periphery|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|regulation of cell cycle|cell cycle|single organismal cell-cell adhesion|cytoplasmic side of plasma membrane|cell cycle process|regulation of cell division|cell-cell contact zone|regulation of cell adhesion|cellular component assembly|cell-cell adhesion|cytoplasm|cell-cell signaling|cytoplasmic side of membrane|positive regulation of cell cycle|postsynaptic density|positive regulation of catalytic activity|cell communication|desmosome|regulation of catalytic activity|positive regulation of cell division|cell division|positive regulation of cytokinesis|cell-cell junction organization|positive regulation of cell cycle process|positive regulation of hydrolase activity|spindle midzone|cell junction assembly|regulation of cytokinesis|regulation of cell cycle process|perinuclear region of cytoplasm|cytoskeleton|cytokinesis|spindle pole|spindle|mitotic spindle|regulation of GTPase activity|positive regulation of GTPase activity|microtubule cytoskeleton|cell-cell junction assembly - - - - 2:158456964-158682879 164 186 337 1256 1421 1196 0.683769563308396 0.704788293452017 1.26680632806116 4.69195201634319 4.86102899979186 4.67332867697498 0.885121394940524 4.74210323103668 -2.42157982886309 6.2814107814097e-23 6.9424273928539e-21 DOWN ENSG00000177374 HIC1 hypermethylated in cancer 1 [Source:HGNC Symbol;Acc:HGNC:4909] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0000785|GO:0043227|GO:0023057|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:2001022|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0009967|GO:0044249|GO:0031324|GO:0031323|GO:1902533|GO:0030111|GO:0003677|GO:0010468|GO:0034645|GO:0030178|GO:0046872|GO:0007166|GO:0010629|GO:0051252|GO:0043517|GO:0031981|GO:2001020|GO:0042826|GO:0005654|GO:0005694|GO:0012501|GO:0035556|GO:0010467|GO:0009059|GO:1902531|GO:0016070|GO:0005634|GO:0006974|GO:0097190|GO:0016055|GO:0097193|GO:1901798|GO:0045892|GO:0072331|GO:0042770|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0008630|GO:1901796|GO:0006351|GO:0006915|GO:0006355|GO:0043516|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122|GO:0030330 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|chromatin|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|cell death|positive regulation of signal transduction|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|regulation of Wnt signaling pathway|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|metal ion binding|cell surface receptor signaling pathway|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|nuclear lumen|regulation of response to DNA damage stimulus|histone deacetylase binding|nucleoplasm|chromosome|programmed cell death|intracellular signal transduction|gene expression|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|apoptotic signaling pathway|Wnt signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of signal transduction by p53 class mediator|negative regulation of transcription, DNA-templated|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of signal transduction by p53 class mediator|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of DNA damage response, signal transduction by p53 class mediator|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter|DNA damage response, signal transduction by p53 class mediator - - - - 17:2054154-2063241 97 103 130 11 12 11 0.524215278496604 0.505892164321341 0.633428567080109 0.05326284052022 0.0532101859781162 0.0557119501799451 0.554512003299351 0.0540616588927604 3.35854100311813 6.43849537367576e-23 7.06672209138662e-21 UP ENSG00000140396 NCOA2 nuclear receptor coactivator 2 [Source:HGNC Symbol;Acc:HGNC:7669] GO:0032502|GO:0000003|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0048786|GO:0048523|GO:0044877|GO:0007622|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0007623|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0003006|GO:0023051|GO:0000989|GO:0044297|GO:0016043|GO:0043227|GO:0044708|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0007626|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0044262|GO:0007618|GO:0044255|GO:0003712|GO:0006725|GO:0043025|GO:0006810|GO:1901360|GO:0006082|GO:0045924|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0005102|GO:0045475|GO:0034641|GO:0005874|GO:0044281|GO:0030902|GO:0031325|GO:0046483|GO:0007420|GO:0032922|GO:0043231|GO:0048608|GO:0019899|GO:0016746|GO:0005737|GO:0060322|GO:0005975|GO:0032403|GO:0043005|GO:0009966|GO:0046983|GO:0007548|GO:0009890|GO:0043197|GO:0036477|GO:0014069|GO:0003682|GO:0019904|GO:0010646|GO:0006139|GO:0008406|GO:0007154|GO:0022037|GO:0006629|GO:0007165|GO:0005783|GO:0008134|GO:0009725|GO:0030546|GO:0021549|GO:0009967|GO:0044249|GO:0010876|GO:0010469|GO:0048512|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0005794|GO:0006996|GO:0003713|GO:0051276|GO:0016922|GO:0006109|GO:0003677|GO:0010468|GO:0034645|GO:0008584|GO:0033993|GO:0043412|GO:0070182|GO:0046661|GO:0044309|GO:0061458|GO:0007417|GO:0010629|GO:0051427|GO:0051252|GO:0006325|GO:0042974|GO:0030165|GO:0016573|GO:0010628|GO:0036211|GO:0005791|GO:0006811|GO:0031981|GO:0045925|GO:0030425|GO:0006869|GO:0005996|GO:0005654|GO:0033143|GO:0016747|GO:0007617|GO:1904017|GO:0008202|GO:0046966|GO:0014070|GO:0035556|GO:0044267|GO:0010467|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0009755|GO:0008206|GO:0016070|GO:0032870|GO:0005856|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0046546|GO:2000273|GO:0043401|GO:0019318|GO:0000975|GO:0045893|GO:0006820|GO:0015711|GO:2000324|GO:0045892|GO:0032774|GO:0030375|GO:0015721|GO:0043565|GO:0060180|GO:2001141|GO:0035257|GO:1902679|GO:0071383|GO:0071407|GO:0003690|GO:0030518|GO:0046942|GO:0010906|GO:0016407|GO:0015630|GO:0046965|GO:0030374|GO:0016410|GO:0019752|GO:0016568|GO:0007264|GO:0006464|GO:0071396|GO:0006351|GO:0006355|GO:0015718|GO:0045944|GO:0006366|GO:1903507|GO:0035258|GO:0006357|GO:1903506|GO:0006006|GO:0044212|GO:0018193|GO:0008080|GO:0032787|GO:0000122|GO:0044213|GO:0000976|GO:0042921|GO:0001012|GO:0035259|GO:0001159|GO:0030331|GO:0033142|GO:0006473|GO:0018205|GO:0018394|GO:0000977|GO:0000987|GO:0006475|GO:0001161|GO:0018393|GO:0001162|GO:0004402|GO:0000978 developmental process|reproduction|synapse|behavior|signaling|cell|rhythmic process|cellular process|reproductive process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|presynaptic active zone|negative regulation of cellular process|macromolecular complex binding|rhythmic behavior|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|transcription factor activity, transcription factor binding|cell body|cellular component organization|membrane-bounded organelle|single-organism behavior|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|endomembrane system|transferase activity|locomotory behavior|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|cellular carbohydrate metabolic process|mating|cellular lipid metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|neuronal cell body|transport|organic cyclic compound metabolic process|organic acid metabolic process|regulation of female receptivity|multicellular organism development|histone modification|nucleic acid binding|animal organ development|receptor binding|locomotor rhythm|cellular nitrogen compound metabolic process|microtubule|small molecule metabolic process|hindbrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|circadian regulation of gene expression|intracellular membrane-bounded organelle|reproductive structure development|enzyme binding|transferase activity, transferring acyl groups|cytoplasm|head development|carbohydrate metabolic process|protein complex binding|neuron projection|regulation of signal transduction|protein dimerization activity|sex differentiation|negative regulation of biosynthetic process|dendritic spine|somatodendritic compartment|postsynaptic density|chromatin binding|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|gonad development|cell communication|metencephalon development|lipid metabolic process|signal transduction|endoplasmic reticulum|transcription factor binding|response to hormone|receptor activator activity|cerebellum development|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|regulation of receptor activity|circadian behavior|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|transcription coactivator activity|chromosome organization|ligand-dependent nuclear receptor binding|regulation of carbohydrate metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gonad development|response to lipid|macromolecule modification|DNA polymerase binding|male sex differentiation|neuron spine|reproductive system development|central nervous system development|negative regulation of gene expression|hormone receptor binding|regulation of RNA metabolic process|chromatin organization|retinoic acid receptor binding|PDZ domain binding|histone acetylation|positive regulation of gene expression|protein modification process|rough endoplasmic reticulum|ion transport|nuclear lumen|positive regulation of female receptivity|dendrite|lipid transport|monosaccharide metabolic process|nucleoplasm|regulation of intracellular steroid hormone receptor signaling pathway|transferase activity, transferring acyl groups other than amino-acyl groups|mating behavior|cellular response to Thyroglobulin triiodothyronine|steroid metabolic process|thyroid hormone receptor binding|response to organic cyclic compound|intracellular signal transduction|cellular protein metabolic process|gene expression|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|bile acid metabolic process|RNA metabolic process|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|development of primary male sexual characteristics|positive regulation of receptor activity|steroid hormone mediated signaling pathway|hexose metabolic process|regulatory region DNA binding|positive regulation of transcription, DNA-templated|anion transport|organic anion transport|positive regulation of glucocorticoid receptor signaling pathway|negative regulation of transcription, DNA-templated|RNA biosynthetic process|thyroid hormone receptor coactivator activity|bile acid and bile salt transport|sequence-specific DNA binding|female mating behavior|regulation of RNA biosynthetic process|nuclear hormone receptor binding|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|carboxylic acid transport|regulation of glucose metabolic process|acetyltransferase activity|microtubule cytoskeleton|retinoid X receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|N-acyltransferase activity|carboxylic acid metabolic process|chromatin modification|small GTPase mediated signal transduction|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|monocarboxylic acid transport|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|glucose metabolic process|transcription regulatory region DNA binding|peptidyl-amino acid modification|N-acetyltransferase activity|monocarboxylic acid metabolic process|negative regulation of transcription from RNA polymerase II promoter|intronic transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|glucocorticoid receptor signaling pathway|RNA polymerase II regulatory region DNA binding|glucocorticoid receptor binding|core promoter proximal region DNA binding|estrogen receptor binding|progesterone receptor binding|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|internal protein amino acid acetylation|intronic transcription regulatory region sequence-specific DNA binding|internal peptidyl-lysine acetylation|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|histone acetyltransferase activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding K11255 nuclear receptor coactivator 2[-] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) 8:70109762-70403805 94 113 93 553 680 549 0.489710282948299 0.53501955807871 0.436823682781707 2.58126567275422 2.90661107689809 2.68047266174277 0.487184507936239 2.72278313713169 -2.48254191732594 6.55260630320544e-23 7.16562302475807e-21 DOWN ENSG00000119787 ATL2 atlastin GTPase 2 [Source:HGNC Symbol;Acc:HGNC:24047] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0042175|GO:0043167|GO:0016043|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0042802|GO:0043168|GO:0001882|GO:0016817|GO:0022607|GO:0043231|GO:0005737|GO:0005783|GO:0000166|GO:0016021|GO:0010256|GO:0006996|GO:0035639|GO:0007030|GO:0001883|GO:0016818|GO:0032549|GO:0006461|GO:0007029|GO:0017076|GO:0032561|GO:0051259|GO:0005525|GO:0019001|GO:0016462|GO:0017111|GO:0051260|GO:0003924 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|cellular component organization|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|identical protein binding|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|nucleotide binding|integral component of membrane|endomembrane system organization|organelle organization|purine ribonucleoside triphosphate binding|Golgi organization|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|protein complex assembly|endoplasmic reticulum organization|purine nucleotide binding|guanyl ribonucleotide binding|protein oligomerization|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|protein homooligomerization|GTPase activity - - - - 2:38294880-38377285 235 295 429 1550 1676 1469 1.63742605336201 1.86808358333169 2.69504368093734 9.67661420346409 9.58155513160914 9.59278559472886 2.06685110587701 9.6169849766007 -2.21815020315879 7.25751291317323e-23 7.90751060255013e-21 DOWN ENSG00000123104 ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 [Source:HGNC Symbol;Acc:HGNC:6181] GO:0032991|GO:0004871|GO:0005215|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0022857|GO:0050794|GO:0043229|GO:0006950|GO:0005057|GO:0042175|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005789|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:0002757|GO:0050817|GO:0045087|GO:0006810|GO:0005938|GO:0033017|GO:0043168|GO:0031095|GO:0015980|GO:0044281|GO:0032940|GO:0006952|GO:0005543|GO:0015278|GO:0043231|GO:0010243|GO:0004888|GO:0005737|GO:0002218|GO:0007267|GO:0009611|GO:0032880|GO:0043235|GO:0001775|GO:0045184|GO:0046883|GO:0022891|GO:0010646|GO:0043085|GO:0050776|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0050778|GO:0005783|GO:0001666|GO:0050790|GO:0006091|GO:0010817|GO:0016021|GO:0010033|GO:0050878|GO:0055114|GO:0071774|GO:0016192|GO:0006909|GO:0030168|GO:0016528|GO:0007166|GO:0090276|GO:0014074|GO:0002758|GO:0051345|GO:0035091|GO:0007596|GO:0046683|GO:0051223|GO:0015031|GO:0071417|GO:0070201|GO:0042060|GO:0015267|GO:0042886|GO:0006811|GO:0002429|GO:0015075|GO:0051046|GO:0031094|GO:0007599|GO:0044344|GO:0009914|GO:0009306|GO:0070848|GO:0051591|GO:0002764|GO:0006112|GO:0014070|GO:0035556|GO:0046903|GO:0071310|GO:0005220|GO:0016529|GO:0038096|GO:0045089|GO:0097305|GO:0045088|GO:0034220|GO:0050796|GO:0002790|GO:0015276|GO:0030073|GO:0098655|GO:0005216|GO:0008543|GO:0006812|GO:0050708|GO:0071363|GO:0015833|GO:0002768|GO:0038179|GO:0071407|GO:0045471|GO:0007167|GO:0002431|GO:0006897|GO:0071320|GO:0019932|GO:0046879|GO:0060193|GO:0008324|GO:0048011|GO:0030072|GO:0002223|GO:0010517|GO:0071361|GO:0038093|GO:0022890|GO:0030001|GO:0048016|GO:0005261|GO:0010518|GO:0007169|GO:0048010|GO:0005262|GO:0010863|GO:0038094|GO:0070588|GO:0038095|GO:0046873|GO:0038127|GO:0007173|GO:0006816|GO:0007202|GO:0015085 macromolecular complex|signal transducer activity|transporter activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|transmembrane transporter activity|regulation of cellular process|intracellular organelle|response to stress|receptor signaling protein activity|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|endoplasmic reticulum membrane|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|immune response-activating signal transduction|coagulation|innate immune response|transport|cell cortex|sarcoplasmic reticulum membrane|anion binding|platelet dense tubular network membrane|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|defense response|phospholipid binding|calcium-release channel activity|intracellular membrane-bounded organelle|response to organonitrogen compound|transmembrane signaling receptor activity|cytoplasm|activation of innate immune response|cell-cell signaling|response to wounding|regulation of protein localization|receptor complex|cell activation|establishment of protein localization|regulation of hormone secretion|substrate-specific transmembrane transporter activity|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|protein localization|cell communication|transmembrane transport|signal transduction|positive regulation of immune response|endoplasmic reticulum|response to hypoxia|regulation of catalytic activity|generation of precursor metabolites and energy|regulation of hormone levels|integral component of membrane|response to organic substance|regulation of body fluid levels|oxidation-reduction process|response to fibroblast growth factor|vesicle-mediated transport|phagocytosis|platelet activation|sarcoplasm|cell surface receptor signaling pathway|regulation of peptide hormone secretion|response to purine-containing compound|innate immune response-activating signal transduction|positive regulation of hydrolase activity|phosphatidylinositol binding|blood coagulation|response to organophosphorus|regulation of protein transport|protein transport|cellular response to organonitrogen compound|regulation of establishment of protein localization|wound healing|channel activity|amide transport|ion transport|immune response-activating cell surface receptor signaling pathway|ion transmembrane transporter activity|regulation of secretion|platelet dense tubular network|hemostasis|cellular response to fibroblast growth factor stimulus|hormone transport|protein secretion|response to growth factor|response to cAMP|immune response-regulating signaling pathway|energy reserve metabolic process|response to organic cyclic compound|intracellular signal transduction|secretion|cellular response to organic substance|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|sarcoplasmic reticulum|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of innate immune response|response to alcohol|regulation of innate immune response|ion transmembrane transport|regulation of insulin secretion|peptide secretion|ligand-gated ion channel activity|insulin secretion|cation transmembrane transport|ion channel activity|fibroblast growth factor receptor signaling pathway|cation transport|regulation of protein secretion|cellular response to growth factor stimulus|peptide transport|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|cellular response to organic cyclic compound|response to ethanol|enzyme linked receptor protein signaling pathway|Fc receptor mediated stimulatory signaling pathway|endocytosis|cellular response to cAMP|second-messenger-mediated signaling|hormone secretion|positive regulation of lipase activity|cation transmembrane transporter activity|neurotrophin TRK receptor signaling pathway|peptide hormone secretion|stimulatory C-type lectin receptor signaling pathway|regulation of phospholipase activity|cellular response to ethanol|Fc receptor signaling pathway|inorganic cation transmembrane transporter activity|metal ion transport|inositol phosphate-mediated signaling|cation channel activity|positive regulation of phospholipase activity|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|calcium channel activity|positive regulation of phospholipase C activity|Fc-gamma receptor signaling pathway|calcium ion transmembrane transport|Fc-epsilon receptor signaling pathway|metal ion transmembrane transporter activity|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|calcium ion transport|activation of phospholipase C activity|calcium ion transmembrane transporter activity K04959 inositol 1,4,5-triphosphate receptor type 2[-] hsa05205|hsa04020|hsa05010|hsa04022|hsa04921|hsa04210|hsa04728|hsa04611|hsa04114|hsa04270|hsa04724|hsa04726|hsa04725|hsa04922|hsa04723|hsa04915|hsa04750|hsa04070|hsa04972|hsa04912|hsa04970|hsa04540|hsa04925|hsa04971|hsa04918|hsa04720|hsa04924|hsa04730 Proteoglycans in cancer - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Renin secretion - Homo sapiens (human)|Long-term depression - Homo sapiens (human) 12:26336515-26833198 20 35 42 282 350 532 0.09866361112436 0.156920705587928 0.186806014053158 1.24644838351482 1.41665062632223 2.45961776248144 0.147463443588482 1.7075722574395 -3.53351737111181 7.29126531999843e-23 7.9153976313903e-21 DOWN ENSG00000196352 CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) [Source:HGNC Symbol;Acc:HGNC:2665] GO:0040011|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0002683|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0006950|GO:0044702|GO:0071704|GO:0006955|GO:0009986|GO:0019953|GO:0044237|GO:0045177|GO:0023051|GO:0051707|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0009607|GO:0009605|GO:0032504|GO:0031224|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048609|GO:0019222|GO:0031225|GO:0016032|GO:0008284|GO:0042127|GO:0002250|GO:0016337|GO:0004857|GO:0045087|GO:0006959|GO:0070661|GO:0050867|GO:0016324|GO:0031664|GO:0070489|GO:0006952|GO:0030155|GO:0001618|GO:0031982|GO:0098609|GO:0005887|GO:0045730|GO:0010243|GO:0005737|GO:0001816|GO:0009611|GO:0042592|GO:0002696|GO:0001775|GO:0009966|GO:0002367|GO:0006956|GO:0019725|GO:0010646|GO:0031226|GO:0009617|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0007276|GO:0007165|GO:0050778|GO:0070062|GO:0045785|GO:0050777|GO:0009725|GO:0050790|GO:0043086|GO:0016021|GO:0060137|GO:0019538|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0007567|GO:0002443|GO:0051701|GO:0002369|GO:0051249|GO:0032268|GO:0005829|GO:0010468|GO:0032943|GO:0048232|GO:0007166|GO:0033993|GO:0006958|GO:0010629|GO:0050727|GO:0002237|GO:0048878|GO:0034109|GO:0051604|GO:1901652|GO:0032269|GO:0071219|GO:0006954|GO:0055082|GO:0051251|GO:0022407|GO:0043434|GO:0030449|GO:0007159|GO:0006508|GO:0002460|GO:0042110|GO:0044267|GO:0010467|GO:0019058|GO:0071310|GO:0051246|GO:0046651|GO:0022409|GO:0045121|GO:0002455|GO:0032496|GO:0002920|GO:0045916|GO:0007283|GO:0042098|GO:0002456|GO:0002673|GO:0050863|GO:0016485|GO:0046718|GO:0030162|GO:0002526|GO:0034112|GO:0070486|GO:0046631|GO:0035743|GO:0045861|GO:0050801|GO:0019724|GO:0030260|GO:0050870|GO:0071396|GO:0050671|GO:0006873|GO:0071222|GO:1903039|GO:0032946|GO:0031663|GO:0016064|GO:0010955|GO:0070613|GO:0042129|GO:0035710|GO:0071593|GO:0030003|GO:0042102|GO:0046633|GO:0046641|GO:0055065|GO:0006875|GO:2000516|GO:0006874|GO:2000563|GO:0055074|GO:0051480|GO:0007204 locomotion|reproduction|immune system process|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of immune system process|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|response to stress|single organism reproductive process|organic substance metabolic process|immune response|cell surface|sexual reproduction|cellular metabolic process|apical part of cell|regulation of signaling|response to other organism|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|response to biotic stimulus|response to external stimulus|multicellular organism reproduction|intrinsic component of membrane|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|multicellular organismal reproductive process|regulation of metabolic process|anchored component of membrane|viral process|positive regulation of cell proliferation|regulation of cell proliferation|adaptive immune response|single organismal cell-cell adhesion|enzyme inhibitor activity|innate immune response|humoral immune response|leukocyte proliferation|positive regulation of cell activation|apical plasma membrane|regulation of lipopolysaccharide-mediated signaling pathway|T cell aggregation|defense response|regulation of cell adhesion|virus receptor activity|vesicle|cell-cell adhesion|integral component of plasma membrane|respiratory burst|response to organonitrogen compound|cytoplasm|cytokine production|response to wounding|homeostatic process|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|cytokine production involved in immune response|complement activation|cellular homeostasis|regulation of cell communication|intrinsic component of plasma membrane|response to bacterium|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|gamete generation|signal transduction|positive regulation of immune response|extracellular exosome|positive regulation of cell adhesion|negative regulation of immune response|response to hormone|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|maternal process involved in parturition|protein metabolic process|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|parturition|leukocyte mediated immunity|interaction with host|T cell cytokine production|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|mononuclear cell proliferation|male gamete generation|cell surface receptor signaling pathway|response to lipid|complement activation, classical pathway|negative regulation of gene expression|regulation of inflammatory response|response to molecule of bacterial origin|chemical homeostasis|homotypic cell-cell adhesion|protein maturation|response to peptide|negative regulation of cellular protein metabolic process|cellular response to molecule of bacterial origin|inflammatory response|cellular chemical homeostasis|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|response to peptide hormone|regulation of complement activation|leukocyte cell-cell adhesion|proteolysis|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|T cell activation|cellular protein metabolic process|gene expression|viral life cycle|cellular response to organic substance|regulation of protein metabolic process|lymphocyte proliferation|positive regulation of cell-cell adhesion|membrane raft|humoral immune response mediated by circulating immunoglobulin|response to lipopolysaccharide|regulation of humoral immune response|negative regulation of complement activation|spermatogenesis|T cell proliferation|T cell mediated immunity|regulation of acute inflammatory response|regulation of T cell activation|protein processing|viral entry into host cell|regulation of proteolysis|acute inflammatory response|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|alpha-beta T cell activation|CD4-positive, alpha-beta T cell cytokine production|negative regulation of proteolysis|ion homeostasis|B cell mediated immunity|entry into host cell|positive regulation of T cell activation|cellular response to lipid|positive regulation of lymphocyte proliferation|cellular ion homeostasis|cellular response to lipopolysaccharide|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|lipopolysaccharide-mediated signaling pathway|immunoglobulin mediated immune response|negative regulation of protein processing|regulation of protein processing|regulation of T cell proliferation|CD4-positive, alpha-beta T cell activation|lymphocyte aggregation|cellular cation homeostasis|positive regulation of T cell proliferation|alpha-beta T cell proliferation|positive regulation of alpha-beta T cell proliferation|metal ion homeostasis|cellular metal ion homeostasis|positive regulation of CD4-positive, alpha-beta T cell activation|cellular calcium ion homeostasis|positive regulation of CD4-positive, alpha-beta T cell proliferation|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04006 decay accelerating factor[-] hsa04640|hsa04610|hsa05416 Hematopoietic cell lineage - Homo sapiens (human)|Complement and coagulation cascades - Homo sapiens (human)|Viral myocarditis - Homo sapiens (human) 1:207321508-207386804 1644 1756 1998 522 463 513 11.2315444161284 10.902899763326 12.3068582646076 3.19525932501091 2.595291684544 3.28461356968745 11.4804341480207 3.02505485974745 1.9241439893021 7.617618521926e-23 8.23972403454996e-21 UP ENSG00000055609 KMT2C lysine (K)-specific methyltransferase 2C [Source:HGNC Symbol;Acc:HGNC:13726] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0003723|GO:0043412|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0035556|GO:0044267|GO:0010467|GO:0009059|GO:0035097|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0018022|GO:0008276|GO:0034968|GO:0046914|GO:0016568|GO:0044822|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0016279|GO:0051568|GO:1903506|GO:0018193|GO:0042054|GO:0008270|GO:0018024|GO:0018205|GO:0042800 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|methylation|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|macromolecule modification|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|protein modification process|nuclear lumen|transferase complex|nucleoplasm|intracellular signal transduction|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|histone methyltransferase complex|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|peptidyl-lysine methylation|protein methyltransferase activity|histone lysine methylation|transition metal ion binding|chromatin modification|poly(A) RNA binding|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|protein-lysine N-methyltransferase activity|histone H3-K4 methylation|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone methyltransferase activity|zinc ion binding|histone-lysine N-methyltransferase activity|peptidyl-lysine modification|histone methyltransferase activity (H3-K4 specific) K09188 histone-lysine N-methyltransferase MLL3[2.1.1.43] hsa00310 Lysine degradation - Homo sapiens (human) 7:152134922-152436005 219 226 513 2149 2359 3035 0.499801452673385 0.4687507749595 1.05556723084021 4.39428513630994 4.41723001966841 6.49144966020385 0.674706486157698 5.10098827206073 -2.91844484768543 7.76468664544454e-23 8.36848213404698e-21 DOWN ENSG00000109861 CTSC cathepsin C [Source:HGNC Symbol;Acc:HGNC:2528] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0050794|GO:0001909|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005615|GO:0030234|GO:0005622|GO:0001913|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0042802|GO:0006486|GO:0002250|GO:0051640|GO:0006810|GO:0010941|GO:0043168|GO:0008047|GO:0031982|GO:0031325|GO:0022607|GO:0010942|GO:0051668|GO:0043231|GO:0051087|GO:0030133|GO:0008233|GO:0019899|GO:0005737|GO:0006903|GO:0005975|GO:0051656|GO:0009966|GO:0010646|GO:0007154|GO:0061024|GO:0007165|GO:0005783|GO:0043621|GO:0070062|GO:0051649|GO:0008219|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0005794|GO:0002443|GO:0006996|GO:0007568|GO:0017171|GO:0016192|GO:0051650|GO:2001235|GO:0032268|GO:0045732|GO:0034645|GO:0006900|GO:0016050|GO:0016504|GO:0043412|GO:0005793|GO:0006487|GO:0090114|GO:0030163|GO:0031410|GO:0031404|GO:0044265|GO:0005773|GO:0033116|GO:0016023|GO:0009100|GO:0036211|GO:0046907|GO:0048199|GO:0019902|GO:0051247|GO:0006508|GO:0031988|GO:0070085|GO:0006461|GO:0002460|GO:0032270|GO:0012501|GO:0008236|GO:1901137|GO:0044267|GO:0042176|GO:0005788|GO:0000139|GO:0051648|GO:0051246|GO:0009059|GO:0043068|GO:0043067|GO:0030134|GO:0097190|GO:0044257|GO:0009101|GO:0004252|GO:0043413|GO:0016505|GO:0002456|GO:0043065|GO:0000323|GO:1903364|GO:0048208|GO:0030162|GO:0045862|GO:0018279|GO:0048193|GO:0051603|GO:0030135|GO:0004175|GO:0042981|GO:0008234|GO:0006464|GO:0006915|GO:1903052|GO:0005764|GO:0018193|GO:0004197|GO:0043687|GO:0006888 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|regulation of cellular process|leukocyte mediated cytotoxicity|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|extracellular space|enzyme regulator activity|intracellular|T cell mediated cytotoxicity|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|identical protein binding|protein glycosylation|adaptive immune response|organelle localization|transport|regulation of cell death|anion binding|enzyme activator activity|vesicle|positive regulation of cellular metabolic process|cellular component assembly|positive regulation of cell death|localization within membrane|intracellular membrane-bounded organelle|chaperone binding|transport vesicle|peptidase activity|enzyme binding|cytoplasm|vesicle targeting|carbohydrate metabolic process|establishment of organelle localization|regulation of signal transduction|regulation of cell communication|cell communication|membrane organization|signal transduction|endoplasmic reticulum|protein self-association|extracellular exosome|establishment of localization in cell|cell death|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|leukocyte mediated immunity|organelle organization|aging|serine hydrolase activity|vesicle-mediated transport|establishment of vesicle localization|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|peptidase activator activity|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation|COPII-coated vesicle budding|protein catabolic process|cytoplasmic vesicle|chloride ion binding|cellular macromolecule catabolic process|vacuole|endoplasmic reticulum-Golgi intermediate compartment membrane|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|protein modification process|intracellular transport|vesicle targeting, to, from or within Golgi|phosphatase binding|positive regulation of protein metabolic process|proteolysis|membrane-bounded vesicle|glycosylation|protein complex assembly|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|positive regulation of cellular protein metabolic process|programmed cell death|serine-type peptidase activity|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of protein catabolic process|endoplasmic reticulum lumen|Golgi membrane|vesicle localization|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of programmed cell death|regulation of programmed cell death|ER to Golgi transport vesicle|apoptotic signaling pathway|cellular protein catabolic process|glycoprotein biosynthetic process|serine-type endopeptidase activity|macromolecule glycosylation|peptidase activator activity involved in apoptotic process|T cell mediated immunity|positive regulation of apoptotic process|lytic vacuole|positive regulation of cellular protein catabolic process|COPII vesicle coating|regulation of proteolysis|positive regulation of proteolysis|protein N-linked glycosylation via asparagine|Golgi vesicle transport|proteolysis involved in cellular protein catabolic process|coated vesicle|endopeptidase activity|regulation of apoptotic process|cysteine-type peptidase activity|cellular protein modification process|apoptotic process|positive regulation of proteolysis involved in cellular protein catabolic process|lysosome|peptidyl-amino acid modification|cysteine-type endopeptidase activity|post-translational protein modification|ER to Golgi vesicle-mediated transport K01275 cathepsin C[3.4.14.1] hsa04210|hsa04142 Apoptosis - Homo sapiens (human)|Lysosome - Homo sapiens (human) 11:88293592-88337787 1302 1342 1495 5860 6216 5355 6.35694408615332 5.95483718171885 6.58101081390264 25.6349594992202 24.9009702822469 24.5033636860805 6.2975973605916 25.0130978225159 -1.9898103172517 9.54938053123214e-23 1.02189718304896e-20 DOWN ENSG00000151014 NOCT nocturnin [Source:HGNC Symbol;Acc:HGNC:14254] GO:0032502|GO:0032991|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0003824|GO:0042752|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0016787|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:1901360|GO:0009991|GO:0007275|GO:0003676|GO:0045596|GO:0030279|GO:0034641|GO:0016788|GO:0046483|GO:0022607|GO:0032922|GO:0045597|GO:0043231|GO:0043169|GO:0005737|GO:0030529|GO:0006139|GO:0009617|GO:0030278|GO:0001503|GO:0048869|GO:0044249|GO:0022613|GO:0043487|GO:0010033|GO:0031323|GO:0006996|GO:0035770|GO:0010468|GO:0034645|GO:0046872|GO:0045668|GO:0003723|GO:0033993|GO:0010629|GO:0002237|GO:0051252|GO:0045667|GO:0044265|GO:0009790|GO:0001649|GO:0022618|GO:0031981|GO:0004518|GO:0045600|GO:0048471|GO:0005654|GO:0070925|GO:0010467|GO:0045598|GO:0019439|GO:0009059|GO:0030154|GO:0016070|GO:0032496|GO:0005634|GO:0036464|GO:0045995|GO:0043488|GO:0006401|GO:0090501|GO:0045444|GO:0034622|GO:0006396|GO:0032774|GO:0048255|GO:2001141|GO:0010608|GO:0004527|GO:0016071|GO:0004540|GO:0044822|GO:0090305|GO:0033962|GO:0006351|GO:0006355|GO:0000932|GO:0004532|GO:0006366|GO:0008408|GO:0003729|GO:1903506|GO:0006402|GO:0006397|GO:0090503|GO:0000956|GO:0000175|GO:0016896|GO:0004535|GO:0000290|GO:0000288 developmental process|macromolecular complex|cell|rhythmic process|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|catalytic activity|regulation of circadian rhythm|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|hydrolase activity|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|response to extracellular stimulus|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|negative regulation of ossification|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cellular component assembly|circadian regulation of gene expression|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|response to bacterium|regulation of ossification|ossification|cellular developmental process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of RNA stability|response to organic substance|regulation of cellular metabolic process|organelle organization|ribonucleoprotein granule|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of osteoblast differentiation|RNA binding|response to lipid|negative regulation of gene expression|response to molecule of bacterial origin|regulation of RNA metabolic process|regulation of osteoblast differentiation|cellular macromolecule catabolic process|embryo development|osteoblast differentiation|ribonucleoprotein complex assembly|nuclear lumen|nuclease activity|positive regulation of fat cell differentiation|perinuclear region of cytoplasm|nucleoplasm|organelle assembly|gene expression|regulation of fat cell differentiation|aromatic compound catabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|response to lipopolysaccharide|nucleus|cytoplasmic ribonucleoprotein granule|regulation of embryonic development|regulation of mRNA stability|RNA catabolic process|RNA phosphodiester bond hydrolysis|fat cell differentiation|cellular macromolecular complex assembly|RNA processing|RNA biosynthetic process|mRNA stabilization|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|exonuclease activity|mRNA metabolic process|ribonuclease activity|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|cytoplasmic mRNA processing body assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|cytoplasmic mRNA processing body|exoribonuclease activity|transcription from RNA polymerase II promoter|3'-5' exonuclease activity|mRNA binding|regulation of nucleic acid-templated transcription|mRNA catabolic process|mRNA processing|RNA phosphodiester bond hydrolysis, exonucleolytic|nuclear-transcribed mRNA catabolic process|3'-5'-exoribonuclease activity|exoribonuclease activity, producing 5'-phosphomonoesters|poly(A)-specific ribonuclease activity|deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay - - - - 4:139015789-139045939 316 346 408 69 81 61 5.24345908205548 5.21778243475441 6.10386528996522 1.02583123019974 1.10276499815151 0.948609919139952 5.52170226892504 1.02573538249707 2.42845450479 9.55012105817176e-23 1.02189718304896e-20 UP ENSG00000183780 SLC35F3 solute carrier family 35 member F3 [Source:HGNC Symbol;Acc:HGNC:23616] GO:0016020|GO:0031224|GO:0006810|GO:0016021|GO:0051180|GO:0015888 membrane|intrinsic component of membrane|transport|integral component of membrane|vitamin transport|thiamine transport - - - - 1:233904933-234324516 35 47 63 357 332 425 0.526872546203261 0.643016306102178 0.855057917272259 4.81511534820206 4.10059165888648 5.99594969632907 0.674982256525899 4.97055223447254 -2.88048466269795 1.04106898125366e-22 1.11000262022667e-20 DOWN ENSG00000138802 SEC24B SEC24 homolog B, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:10704] GO:0032502|GO:0032991|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0019882|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0048514|GO:0007507|GO:0060341|GO:0006486|GO:0035239|GO:0051640|GO:0035459|GO:0009888|GO:0007164|GO:0048468|GO:0019884|GO:0006810|GO:0035295|GO:0048839|GO:0001568|GO:0007275|GO:0030324|GO:0060627|GO:0048513|GO:0048857|GO:0021548|GO:0044281|GO:0030902|GO:0031982|GO:0051128|GO:0007420|GO:0022607|GO:0030117|GO:0051668|GO:0043231|GO:0043169|GO:0030133|GO:0005737|GO:0060322|GO:0007423|GO:0012506|GO:0006903|GO:0005975|GO:0009887|GO:0051656|GO:0021915|GO:0060463|GO:0048729|GO:0048598|GO:0048568|GO:0045184|GO:0030658|GO:0030323|GO:0008104|GO:0035148|GO:0061024|GO:0022037|GO:0005783|GO:0003151|GO:0051649|GO:0002504|GO:0060462|GO:0048002|GO:0030030|GO:0048869|GO:0044249|GO:0019538|GO:0043254|GO:0005794|GO:0006996|GO:0016192|GO:0060425|GO:0051650|GO:0000902|GO:0012507|GO:0005829|GO:0034645|GO:0002093|GO:0006900|GO:0060113|GO:0046872|GO:0016050|GO:0002009|GO:0001944|GO:0043412|GO:0006487|GO:0090114|GO:0072358|GO:0007417|GO:0031410|GO:0043583|GO:0021747|GO:0060976|GO:0002064|GO:0060541|GO:0032386|GO:0003007|GO:0015031|GO:1901301|GO:0000904|GO:0009790|GO:0001736|GO:0016023|GO:0072175|GO:0009100|GO:0036211|GO:0060840|GO:0048844|GO:0046907|GO:2000027|GO:0048199|GO:0042472|GO:0016331|GO:0060977|GO:0060122|GO:0048471|GO:0031988|GO:0070085|GO:0090110|GO:0006461|GO:0002474|GO:0001841|GO:0034613|GO:0060429|GO:0030659|GO:1901137|GO:0033043|GO:0044267|GO:0090177|GO:0048562|GO:0007399|GO:0060562|GO:0000139|GO:0060628|GO:0051648|GO:0009059|GO:0030154|GO:0060606|GO:0030120|GO:0072359|GO:0030134|GO:0051960|GO:0045995|GO:0002495|GO:0048666|GO:0030182|GO:0009101|GO:0043413|GO:0009792|GO:0061156|GO:0034622|GO:0030855|GO:0001843|GO:0060088|GO:0042249|GO:0002066|GO:0048208|GO:0001838|GO:0043623|GO:0018279|GO:0048193|GO:0008544|GO:0090175|GO:0016482|GO:0006886|GO:0042471|GO:0030135|GO:0019886|GO:0035909|GO:0090178|GO:0035904|GO:0046914|GO:0042491|GO:0030127|GO:0060119|GO:0060982|GO:0022008|GO:0048667|GO:0006464|GO:0001738|GO:0048699|GO:0018193|GO:0035315|GO:0060117|GO:0043009|GO:0043687|GO:0042490|GO:0006888|GO:0008270|GO:0009913|GO:0060563 developmental process|macromolecular complex|transporter activity|immune system process|cell|membrane|cellular process|metabolic process|binding|regulation of cellular process|antigen processing and presentation|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|blood vessel morphogenesis|heart development|regulation of cellular localization|protein glycosylation|tube morphogenesis|organelle localization|cargo loading into vesicle|tissue development|establishment of tissue polarity|cell development|antigen processing and presentation of exogenous antigen|transport|tube development|inner ear development|blood vessel development|multicellular organism development|lung development|regulation of vesicle-mediated transport|animal organ development|neural nucleus development|pons development|small molecule metabolic process|hindbrain development|vesicle|regulation of cellular component organization|brain development|cellular component assembly|membrane coat|localization within membrane|intracellular membrane-bounded organelle|cation binding|transport vesicle|cytoplasm|head development|sensory organ development|vesicle membrane|vesicle targeting|carbohydrate metabolic process|organ morphogenesis|establishment of organelle localization|neural tube development|lung lobe morphogenesis|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|establishment of protein localization|transport vesicle membrane|respiratory tube development|protein localization|tube formation|membrane organization|metencephalon development|endoplasmic reticulum|outflow tract morphogenesis|establishment of localization in cell|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|lung lobe development|antigen processing and presentation of peptide antigen|cell projection organization|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of protein complex assembly|Golgi apparatus|organelle organization|vesicle-mediated transport|lung morphogenesis|establishment of vesicle localization|cell morphogenesis|ER to Golgi transport vesicle membrane|cytosol|cellular macromolecule biosynthetic process|auditory receptor cell morphogenesis|membrane budding|inner ear receptor cell differentiation|metal ion binding|vesicle organization|morphogenesis of an epithelium|vasculature development|macromolecule modification|protein N-linked glycosylation|COPII-coated vesicle budding|cardiovascular system development|central nervous system development|cytoplasmic vesicle|ear development|cochlear nucleus development|coronary vasculature development|epithelial cell development|respiratory system development|regulation of intracellular transport|heart morphogenesis|protein transport|regulation of cargo loading into COPII-coated vesicle|cell morphogenesis involved in differentiation|embryo development|establishment of planar polarity|cytoplasmic, membrane-bounded vesicle|epithelial tube formation|glycoprotein metabolic process|protein modification process|artery development|artery morphogenesis|intracellular transport|regulation of organ morphogenesis|vesicle targeting, to, from or within Golgi|inner ear morphogenesis|morphogenesis of embryonic epithelium|coronary vasculature morphogenesis|inner ear receptor stereocilium organization|perinuclear region of cytoplasm|membrane-bounded vesicle|glycosylation|cargo loading into COPII-coated vesicle|protein complex assembly|antigen processing and presentation of peptide antigen via MHC class I|neural tube formation|cellular protein localization|epithelium development|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|establishment of planar polarity involved in neural tube closure|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|Golgi membrane|regulation of ER to Golgi vesicle-mediated transport|vesicle localization|macromolecule biosynthetic process|cell differentiation|tube closure|vesicle coat|circulatory system development|ER to Golgi transport vesicle|regulation of nervous system development|regulation of embryonic development|antigen processing and presentation of peptide antigen via MHC class II|neuron development|neuron differentiation|glycoprotein biosynthetic process|macromolecule glycosylation|embryo development ending in birth or egg hatching|pulmonary artery morphogenesis|cellular macromolecular complex assembly|epithelial cell differentiation|neural tube closure|auditory receptor cell stereocilium organization|establishment of planar polarity of embryonic epithelium|columnar/cuboidal epithelial cell development|COPII vesicle coating|embryonic epithelial tube formation|cellular protein complex assembly|protein N-linked glycosylation via asparagine|Golgi vesicle transport|epidermis development|regulation of establishment of planar polarity|cytosolic transport|intracellular protein transport|ear morphogenesis|coated vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class II|aorta morphogenesis|regulation of establishment of planar polarity involved in neural tube closure|aorta development|transition metal ion binding|auditory receptor cell differentiation|COPII vesicle coat|inner ear receptor cell development|coronary artery morphogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|morphogenesis of a polarized epithelium|generation of neurons|peptidyl-amino acid modification|hair cell differentiation|auditory receptor cell development|chordate embryonic development|post-translational protein modification|mechanoreceptor differentiation|ER to Golgi vesicle-mediated transport|zinc ion binding|epidermal cell differentiation|neuroepithelial cell differentiation K14007 protein transport protein SEC24[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 4:109433772-109540896 129 149 230 890 921 842 1.49566633608935 1.57004399843292 2.40428642339316 9.24553930072472 8.76137656608131 9.14925074026035 1.82333225263848 9.05205553568879 -2.31166795857073 1.07852460897456e-22 1.14584603830344e-20 DOWN ENSG00000015171 ZMYND11 zinc finger, MYND-type containing 11 [Source:HGNC Symbol;Acc:HGNC:16966] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0000989|GO:0016043|GO:0043227|GO:0023057|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0019222|GO:0016032|GO:0007049|GO:0003712|GO:0006725|GO:0042393|GO:1901360|GO:0010941|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0009966|GO:0009890|GO:0003682|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0016021|GO:0044249|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0006996|GO:0000165|GO:0051276|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0046872|GO:0007166|GO:0043412|GO:0010629|GO:0043069|GO:2001234|GO:0051252|GO:0006325|GO:0036211|GO:0032269|GO:0031981|GO:0031098|GO:0005654|GO:0005694|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0035064|GO:1902532|GO:0051246|GO:0009059|GO:1902531|GO:0016070|GO:0005634|GO:0043067|GO:0097190|GO:2001237|GO:0000975|GO:0043124|GO:0043122|GO:0043408|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:2001236|GO:0016310|GO:1902679|GO:0003690|GO:0007249|GO:0032872|GO:0042981|GO:0046914|GO:0043066|GO:0043409|GO:0016568|GO:0006464|GO:0097191|GO:0051403|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:0032784|GO:1903507|GO:0046328|GO:0006357|GO:0006468|GO:1903506|GO:0044212|GO:0042325|GO:0006354|GO:0007254|GO:0001932|GO:0042326|GO:0001933|GO:0000122|GO:0008270|GO:0032873|GO:0006368|GO:0000976|GO:0001012|GO:0034243|GO:0046329|GO:0000977 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|regulation of metabolic process|viral process|cell cycle|transcription cofactor activity|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|regulation of cell death|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|regulation of signal transduction|negative regulation of biosynthetic process|chromatin binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|cell death|integral component of membrane|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|MAPK cascade|chromosome organization|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|negative regulation of gene expression|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|chromatin organization|protein modification process|negative regulation of cellular protein metabolic process|nuclear lumen|stress-activated protein kinase signaling cascade|nucleoplasm|chromosome|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|methylated histone binding|negative regulation of intracellular signal transduction|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|nucleus|regulation of programmed cell death|apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|regulatory region DNA binding|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of extrinsic apoptotic signaling pathway|phosphorylation|negative regulation of RNA biosynthetic process|double-stranded DNA binding|I-kappaB kinase/NF-kappaB signaling|regulation of stress-activated MAPK cascade|regulation of apoptotic process|transition metal ion binding|negative regulation of apoptotic process|negative regulation of MAPK cascade|chromatin modification|cellular protein modification process|extrinsic apoptotic signaling pathway|stress-activated MAPK cascade|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|negative regulation of nucleic acid-templated transcription|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of phosphorylation|DNA-templated transcription, elongation|JNK cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|negative regulation of stress-activated MAPK cascade|transcription elongation from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|regulation of transcription elongation from RNA polymerase II promoter|negative regulation of JNK cascade|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 10:134465-254637 236 230 307 1204 1358 1008 1.3005543773102 1.15192267670505 1.52534756546728 5.94484121300617 6.14021532791179 5.20601611358972 1.32594153982751 5.76369088483589 -2.11997579467402 1.3754069253896e-22 1.45607795569436e-20 DOWN ENSG00000144366 GULP1 GULP, engulfment adaptor PTB domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18649] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0016043|GO:0005622|GO:0005515|GO:0006810|GO:0005737|GO:0007154|GO:0061024|GO:0007165|GO:0008219|GO:0010876|GO:0016192|GO:0006909|GO:0006869|GO:0010324|GO:0012501|GO:0006911|GO:0006897|GO:0006915 signal transducer activity|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|cellular component organization|intracellular|protein binding|transport|cytoplasm|cell communication|membrane organization|signal transduction|cell death|lipid localization|vesicle-mediated transport|phagocytosis|lipid transport|membrane invagination|programmed cell death|phagocytosis, engulfment|endocytosis|apoptotic process - - - - 2:188291669-188595931 24 29 71 395 476 434 0.0780466978532944 0.0857099202349616 0.208171274790183 1.15090893636618 1.27005247580087 1.32271100810041 0.123975964292813 1.24789080675582 -3.33135934879137 1.45438667369012e-22 1.53424946135494e-20 DOWN ENSG00000065413 ANKRD44 ankyrin repeat domain 44 [Source:HGNC Symbol;Acc:HGNC:25259] GO:0005488|GO:0005515 binding|protein binding - - - - 2:196967017-197311173 5 2 2 86 85 74 0.0261245989523062 0.0094966101010517 0.00942138296723739 0.402582241639091 0.364371360865605 0.362344324448242 0.0150141973401984 0.376432642317646 -4.64799248112784 1.62041627969916e-22 1.70337702866685e-20 DOWN ENSG00000162105 SHANK2 SH3 and multiple ankyrin repeat domains 2 [Source:HGNC Symbol;Acc:HGNC:14295] GO:0032502|GO:0032991|GO:0045202|GO:0007610|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0042995|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0032947|GO:0045177|GO:0023051|GO:0044297|GO:0016043|GO:0030427|GO:0043227|GO:0044708|GO:0071944|GO:0023057|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0097060|GO:0005929|GO:0031090|GO:0005903|GO:0071625|GO:0050804|GO:0043025|GO:0030534|GO:0016324|GO:0030159|GO:0098797|GO:0007275|GO:0050877|GO:0005102|GO:0060170|GO:0030426|GO:0045211|GO:0050806|GO:0022607|GO:0005882|GO:0050803|GO:0005887|GO:0005737|GO:0007267|GO:0043235|GO:0001917|GO:0043005|GO:0072372|GO:0043197|GO:0036477|GO:0014069|GO:0019904|GO:0010646|GO:0031226|GO:1902495|GO:0007154|GO:0035176|GO:0001750|GO:0050808|GO:0007611|GO:0031253|GO:0050805|GO:0016021|GO:0060292|GO:0008328|GO:0005883|GO:0048167|GO:0007416|GO:0044309|GO:0007612|GO:0031526|GO:0017124|GO:0030425|GO:0034702|GO:0030160|GO:0060291|GO:0007399|GO:0050890|GO:0005856|GO:0035254|GO:0031513|GO:0035255|GO:0045111|GO:0007268 developmental process|macromolecular complex|synapse|behavior|structural molecule activity|signaling|cell|membrane|cellular process|cell junction|binding|cell projection|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|protein complex scaffold|apical part of cell|regulation of signaling|cell body|cellular component organization|site of polarized growth|membrane-bounded organelle|single-organism behavior|cell periphery|negative regulation of signaling|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|synaptic membrane|cilium|organelle membrane|brush border|vocalization behavior|modulation of synaptic transmission|neuronal cell body|adult behavior|apical plasma membrane|receptor signaling complex scaffold activity|plasma membrane protein complex|multicellular organism development|neurological system process|receptor binding|ciliary membrane|growth cone|postsynaptic membrane|positive regulation of synaptic transmission|cellular component assembly|intermediate filament|regulation of synapse structure or activity|integral component of plasma membrane|cytoplasm|cell-cell signaling|receptor complex|photoreceptor inner segment|neuron projection|primary cilium|dendritic spine|somatodendritic compartment|postsynaptic density|protein domain specific binding|regulation of cell communication|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|social behavior|photoreceptor outer segment|synapse organization|learning or memory|cell projection membrane|negative regulation of synaptic transmission|integral component of membrane|long term synaptic depression|ionotropic glutamate receptor complex|neurofilament|regulation of synaptic plasticity|synapse assembly|neuron spine|learning|brush border membrane|SH3 domain binding|dendrite|ion channel complex|GKAP/Homer scaffold activity|long-term synaptic potentiation|nervous system development|cognition|cytoskeleton|glutamate receptor binding|nonmotile primary cilium|ionotropic glutamate receptor binding|intermediate filament cytoskeleton|synaptic transmission K15009 SH3 and multiple ankyrin repeat domains protein[-] hsa04724 Glutamatergic synapse - Homo sapiens (human) 11:70467856-71252577 35 37 112 648 739 888 0.0841899579899046 0.0808875642392437 0.242899363368269 1.3965852310186 1.45850254954694 2.00187527303723 0.135992295199139 1.61898768453426 -3.57349518990918 1.70712058514695e-22 1.7882237876834e-20 DOWN ENSG00000102595 UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:15664] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0006457|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0006486|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0005975|GO:0006139|GO:0005783|GO:0016757|GO:0044249|GO:0019538|GO:0034645|GO:0009225|GO:0043412|GO:0005793|GO:0006487|GO:0008194|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0005788|GO:0009059|GO:0009101|GO:0046527|GO:0043413|GO:0018279|GO:0006011|GO:0035251|GO:0006464|GO:0097359|GO:0003980|GO:0018193|GO:0043687 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|protein folding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|transferase activity|protein glycosylation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|nucleobase-containing compound metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|nucleotide-sugar metabolic process|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation|UDP-glycosyltransferase activity|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|endoplasmic reticulum lumen|macromolecule biosynthetic process|glycoprotein biosynthetic process|glucosyltransferase activity|macromolecule glycosylation|protein N-linked glycosylation via asparagine|UDP-glucose metabolic process|UDP-glucosyltransferase activity|cellular protein modification process|UDP-glucosylation|UDP-glucose:glycoprotein glucosyltransferase activity|peptidyl-amino acid modification|post-translational protein modification K11718 UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-][-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 13:95801580-96053482 65 104 147 668 665 764 0.404247714520122 0.587821295606051 0.824260596472552 3.72226120456309 3.39329747814758 4.45302057113705 0.605443202199575 3.85619308461591 -2.6711137616365 2.11411424160566e-22 2.20681001989145e-20 DOWN ENSG00000134138 MEIS2 Meis homeobox 2 [Source:HGNC Symbol;Acc:HGNC:7001] GO:0032502|GO:0002376|GO:0007610|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0002683|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009628|GO:0044237|GO:0000989|GO:0043227|GO:0044708|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:1903706|GO:0045595|GO:0003712|GO:0006725|GO:0009314|GO:0009612|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0050877|GO:0034641|GO:0031325|GO:0046483|GO:0007632|GO:0043231|GO:0005737|GO:0000981|GO:0007423|GO:0009890|GO:0006139|GO:0008134|GO:0007611|GO:0031016|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0001654|GO:0030097|GO:0007612|GO:0010629|GO:0051252|GO:0010628|GO:0048471|GO:0070848|GO:0010467|GO:0050890|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0009416|GO:0045638|GO:0045637|GO:0008542|GO:0000975|GO:0045893|GO:0045892|GO:0032774|GO:0008306|GO:0043565|GO:2001141|GO:0001077|GO:1902679|GO:0003690|GO:0030099|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|immune system process|behavior|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|single-organism behavior|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|regulation of hemopoiesis|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|response to radiation|response to mechanical stimulus|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|neurological system process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|visual behavior|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|sensory organ development|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|transcription factor binding|learning or memory|pancreas development|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|eye development|hemopoiesis|learning|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|perinuclear region of cytoplasm|response to growth factor|gene expression|cognition|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|negative regulation of myeloid cell differentiation|regulation of myeloid cell differentiation|visual learning|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|associative learning|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of RNA biosynthetic process|double-stranded DNA binding|myeloid cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 15:36889204-37101299 79 69 75 453 512 421 0.208203553883241 0.165270278245666 0.178213628063447 1.0696919671613 1.10713590555418 1.0398593383584 0.183895820064118 1.07222907035796 -2.54365256230036 2.27366298635821e-22 2.36508483605359e-20 DOWN ENSG00000155657 TTN titin [Source:HGNC Symbol;Acc:HGNC:12403] GO:0032502|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0051606|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0097493|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0008307|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0030017|GO:0007507|GO:0030018|GO:0007049|GO:0050817|GO:0009888|GO:0048468|GO:0006810|GO:0022402|GO:0009612|GO:0007275|GO:0048513|GO:0043168|GO:0005859|GO:0032940|GO:0001882|GO:0016772|GO:0031982|GO:0022607|GO:0009582|GO:0061061|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0009611|GO:0006928|GO:0009887|GO:0032403|GO:0001775|GO:0048729|GO:0031430|GO:0031672|GO:0031674|GO:0016459|GO:0005516|GO:0043621|GO:0070062|GO:0008092|GO:0050790|GO:0007059|GO:0000166|GO:0048869|GO:0030029|GO:0010035|GO:0019538|GO:0031323|GO:0050878|GO:0003013|GO:0006996|GO:0016192|GO:0051276|GO:0032268|GO:0005829|GO:0000819|GO:0006936|GO:0030168|GO:0046872|GO:0005865|GO:0035639|GO:1903047|GO:0043412|GO:0007010|GO:0072358|GO:0042692|GO:0007596|GO:0035051|GO:0030048|GO:0048738|GO:0001883|GO:0003779|GO:0003007|GO:0055006|GO:0010038|GO:0006887|GO:0036211|GO:0000278|GO:0060537|GO:0042060|GO:0032549|GO:0042805|GO:0002020|GO:0043292|GO:0031981|GO:0007599|GO:0035994|GO:0005694|GO:0000228|GO:0006461|GO:0016301|GO:0055001|GO:0030036|GO:0051015|GO:0070925|GO:0019900|GO:0050982|GO:0006796|GO:0044267|GO:0051174|GO:0007067|GO:0014896|GO:0046903|GO:0017076|GO:0060415|GO:0051246|GO:0030154|GO:0030239|GO:0007517|GO:0072359|GO:0016773|GO:0008015|GO:0005856|GO:0005634|GO:0030261|GO:0016460|GO:0048644|GO:0031433|GO:0006941|GO:0055002|GO:0014866|GO:0015629|GO:0055003|GO:0070252|GO:0030016|GO:0045055|GO:0048739|GO:0034622|GO:0051393|GO:0055013|GO:0000793|GO:0005524|GO:0060047|GO:0051592|GO:0043623|GO:0030554|GO:0016310|GO:0005509|GO:0000794|GO:0007076|GO:0035995|GO:0000070|GO:0051146|GO:0030049|GO:0004672|GO:0030241|GO:0031032|GO:0055008|GO:0019901|GO:0014706|GO:0055007|GO:0006464|GO:0007015|GO:0045214|GO:0071103|GO:0048769|GO:0043549|GO:0003300|GO:0006323|GO:0030240|GO:0045859|GO:0006468|GO:0033275|GO:0060048|GO:0042325|GO:0004713|GO:0001932|GO:0018193|GO:0048747|GO:0004674|GO:0051371|GO:0002576|GO:0018108 developmental process|macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|detection of stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|structural molecule activity conferring elasticity|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|structural constituent of muscle|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|sarcomere|heart development|Z disc|cell cycle|coagulation|tissue development|cell development|transport|cell cycle process|response to mechanical stimulus|multicellular organism development|animal organ development|anion binding|muscle myosin complex|secretion by cell|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|cellular component assembly|detection of abiotic stimulus|muscle structure development|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|muscle system process|response to wounding|movement of cell or subcellular component|organ morphogenesis|protein complex binding|cell activation|tissue morphogenesis|M band|A band|I band|myosin complex|calmodulin binding|protein self-association|extracellular exosome|cytoskeletal protein binding|regulation of catalytic activity|chromosome segregation|nucleotide binding|cellular developmental process|actin filament-based process|response to inorganic substance|protein metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|organelle organization|vesicle-mediated transport|chromosome organization|regulation of cellular protein metabolic process|cytosol|sister chromatid segregation|muscle contraction|platelet activation|metal ion binding|striated muscle thin filament|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|cardiovascular system development|muscle cell differentiation|blood coagulation|cardiocyte differentiation|actin filament-based movement|cardiac muscle tissue development|purine nucleoside binding|actin binding|heart morphogenesis|cardiac cell development|response to metal ion|exocytosis|protein modification process|mitotic cell cycle|muscle tissue development|wound healing|ribonucleoside binding|actinin binding|protease binding|contractile fiber|nuclear lumen|hemostasis|response to muscle stretch|chromosome|nuclear chromosome|protein complex assembly|kinase activity|muscle cell development|actin cytoskeleton organization|actin filament binding|organelle assembly|kinase binding|detection of mechanical stimulus|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|muscle hypertrophy|secretion|purine nucleotide binding|muscle tissue morphogenesis|regulation of protein metabolic process|cell differentiation|myofibril assembly|muscle organ development|circulatory system development|phosphotransferase activity, alcohol group as acceptor|blood circulation|cytoskeleton|nucleus|chromosome condensation|myosin II complex|muscle organ morphogenesis|telethonin binding|striated muscle contraction|striated muscle cell development|skeletal myofibril assembly|actin cytoskeleton|cardiac myofibril assembly|actin-mediated cell contraction|myofibril|regulated exocytosis|cardiac muscle fiber development|cellular macromolecular complex assembly|alpha-actinin binding|cardiac muscle cell development|condensed chromosome|ATP binding|heart contraction|response to calcium ion|cellular protein complex assembly|adenyl nucleotide binding|phosphorylation|calcium ion binding|condensed nuclear chromosome|mitotic chromosome condensation|detection of muscle stretch|mitotic sister chromatid segregation|striated muscle cell differentiation|muscle filament sliding|protein kinase activity|skeletal muscle myosin thick filament assembly|actomyosin structure organization|cardiac muscle tissue morphogenesis|protein kinase binding|striated muscle tissue development|cardiac muscle cell differentiation|cellular protein modification process|actin filament organization|sarcomere organization|DNA conformation change|sarcomerogenesis|regulation of kinase activity|cardiac muscle hypertrophy|DNA packaging|skeletal muscle thin filament assembly|regulation of protein kinase activity|protein phosphorylation|actin-myosin filament sliding|cardiac muscle contraction|regulation of phosphorylation|protein tyrosine kinase activity|regulation of protein phosphorylation|peptidyl-amino acid modification|muscle fiber development|protein serine/threonine kinase activity|muscle alpha-actinin binding|platelet degranulation|peptidyl-tyrosine phosphorylation K12567 titin[2.7.11.1] hsa05414|hsa05410 Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) 2:178525989-178830802 74 97 125 529 561 598 0.0435236736146455 0.0518495932146073 0.0662849352730222 0.278769666001254 0.270721510184502 0.32962677352563 0.053886067367425 0.293039316570462 -2.44311003442866 2.55295709627982e-22 2.64638823445618e-20 DOWN ENSG00000127616 SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 [Source:HGNC Symbol;Acc:HGNC:11100] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0023051|GO:0000989|GO:0045926|GO:0000785|GO:0016043|GO:0043227|GO:0040008|GO:0023057|GO:0009893|GO:0032504|GO:0016787|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0016032|GO:0047485|GO:0051726|GO:0007049|GO:0003712|GO:0006725|GO:0060041|GO:0042393|GO:0048468|GO:0022402|GO:1901360|GO:0007275|GO:0051702|GO:0003676|GO:0048513|GO:0005102|GO:0002039|GO:0034641|GO:0043168|GO:0001882|GO:0048524|GO:0031325|GO:0046483|GO:0051128|GO:0016817|GO:0070603|GO:0045786|GO:0043231|GO:1902661|GO:0019899|GO:0030308|GO:0001076|GO:0007423|GO:0032403|GO:0042592|GO:0048515|GO:0003407|GO:0009966|GO:0009890|GO:0019725|GO:0003682|GO:0010646|GO:0006139|GO:0000790|GO:0007154|GO:0007276|GO:0007165|GO:0009968|GO:0008134|GO:0009725|GO:0000166|GO:0071565|GO:0048869|GO:0009967|GO:0044249|GO:0050792|GO:0010033|GO:0001558|GO:0031324|GO:0007281|GO:0031323|GO:0006996|GO:0051090|GO:0003713|GO:0051276|GO:0005730|GO:0030111|GO:0003677|GO:0009743|GO:0010468|GO:0007286|GO:0034645|GO:0003714|GO:0048232|GO:0007166|GO:0001654|GO:0033993|GO:0035639|GO:1903047|GO:0070182|GO:0001104|GO:0010629|GO:0051427|GO:0070577|GO:0048878|GO:0051252|GO:0006325|GO:0001883|GO:0044770|GO:0010628|GO:0016818|GO:0000278|GO:0019083|GO:0032549|GO:0055082|GO:0051091|GO:0031981|GO:0007346|GO:0009756|GO:0010564|GO:0045930|GO:0005654|GO:0031491|GO:0033143|GO:0005694|GO:0000228|GO:0033144|GO:0030957|GO:0014070|GO:1903902|GO:0007067|GO:0010467|GO:0007399|GO:0019058|GO:0071310|GO:0017076|GO:0090544|GO:0031328|GO:0030177|GO:0009059|GO:0030154|GO:0009755|GO:0006337|GO:0001191|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0010948|GO:0031490|GO:0043401|GO:0071322|GO:0016055|GO:0007283|GO:0043241|GO:0000975|GO:0045893|GO:0001678|GO:0043566|GO:0045892|GO:0043010|GO:0071564|GO:0046782|GO:0032774|GO:0005524|GO:0044772|GO:0043565|GO:0034660|GO:2001141|GO:0035257|GO:0034728|GO:0034284|GO:0030554|GO:1902679|GO:0060766|GO:0071383|GO:0071407|GO:0031492|GO:0003690|GO:0030518|GO:1901990|GO:0001105|GO:0006333|GO:0060765|GO:0016568|GO:1901987|GO:0050434|GO:0071396|GO:0016514|GO:0016462|GO:0006351|GO:0006355|GO:0033500|GO:1901991|GO:0045943|GO:0071333|GO:0042593|GO:0045944|GO:2000045|GO:0006366|GO:1903507|GO:0035258|GO:0006357|GO:0006360|GO:0043923|GO:1903506|GO:0044212|GO:0017111|GO:0001190|GO:0007070|GO:1902806|GO:0030521|GO:2000134|GO:0000082|GO:0006356|GO:0006338|GO:0000122|GO:1902807|GO:0009303|GO:0050681|GO:0016887|GO:0035326|GO:1901838|GO:0001047|GO:0000976|GO:0001012|GO:1902895|GO:0009749|GO:0010255|GO:0001159|GO:0004386|GO:0043044|GO:0001013|GO:0001046|GO:0042623|GO:0000977|GO:0000987|GO:0001158|GO:0001164|GO:0000980|GO:0008094|GO:0000978 developmental process|growth|macromolecular complex|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|transcription factor activity, transcription factor binding|negative regulation of growth|chromatin|cellular component organization|membrane-bounded organelle|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|biosynthetic process|extracellular space|intracellular|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|viral process|protein N-terminus binding|regulation of cell cycle|cell cycle|transcription cofactor activity|cellular aromatic compound metabolic process|retina development in camera-type eye|histone binding|cell development|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|interaction with symbiont|nucleic acid binding|animal organ development|receptor binding|p53 binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|SWI/SNF superfamily-type complex|negative regulation of cell cycle|intracellular membrane-bounded organelle|positive regulation of glucose mediated signaling pathway|enzyme binding|negative regulation of cell growth|transcription factor activity, RNA polymerase II transcription factor binding|sensory organ development|protein complex binding|homeostatic process|spermatid differentiation|neural retina development|regulation of signal transduction|negative regulation of biosynthetic process|cellular homeostasis|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|nuclear chromatin|cell communication|gamete generation|signal transduction|negative regulation of signal transduction|transcription factor binding|response to hormone|nucleotide binding|nBAF complex|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|regulation of viral process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|transcription coactivator activity|chromosome organization|nucleolus|regulation of Wnt signaling pathway|DNA binding|response to carbohydrate|regulation of gene expression|spermatid development|cellular macromolecule biosynthetic process|transcription corepressor activity|male gamete generation|cell surface receptor signaling pathway|eye development|response to lipid|purine ribonucleoside triphosphate binding|mitotic cell cycle process|DNA polymerase binding|RNA polymerase II transcription cofactor activity|negative regulation of gene expression|hormone receptor binding|lysine-acetylated histone binding|chemical homeostasis|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|cell cycle phase transition|positive regulation of gene expression|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|viral transcription|ribonucleoside binding|cellular chemical homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|nuclear lumen|regulation of mitotic cell cycle|carbohydrate mediated signaling|regulation of cell cycle process|negative regulation of mitotic cell cycle|nucleoplasm|nucleosome binding|regulation of intracellular steroid hormone receptor signaling pathway|chromosome|nuclear chromosome|negative regulation of intracellular steroid hormone receptor signaling pathway|Tat protein binding|response to organic cyclic compound|positive regulation of viral life cycle|mitotic nuclear division|gene expression|nervous system development|viral life cycle|cellular response to organic substance|purine nucleotide binding|BAF-type complex|positive regulation of cellular biosynthetic process|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|nucleosome disassembly|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|negative regulation of cell cycle process|chromatin DNA binding|steroid hormone mediated signaling pathway|cellular response to carbohydrate stimulus|Wnt signaling pathway|spermatogenesis|protein complex disassembly|regulatory region DNA binding|positive regulation of transcription, DNA-templated|cellular glucose homeostasis|structure-specific DNA binding|negative regulation of transcription, DNA-templated|camera-type eye development|npBAF complex|regulation of viral transcription|RNA biosynthetic process|ATP binding|mitotic cell cycle phase transition|sequence-specific DNA binding|ncRNA metabolic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|nucleosome organization|response to monosaccharide|adenyl nucleotide binding|negative regulation of RNA biosynthetic process|negative regulation of androgen receptor signaling pathway|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|nucleosomal DNA binding|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|regulation of mitotic cell cycle phase transition|RNA polymerase II transcription coactivator activity|chromatin assembly or disassembly|regulation of androgen receptor signaling pathway|chromatin modification|regulation of cell cycle phase transition|positive regulation of viral transcription|cellular response to lipid|SWI/SNF complex|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|carbohydrate homeostasis|negative regulation of mitotic cell cycle phase transition|positive regulation of transcription from RNA polymerase I promoter|cellular response to glucose stimulus|glucose homeostasis|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase I promoter|positive regulation by host of viral transcription|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|nucleoside-triphosphatase activity|transcriptional activator activity, RNA polymerase II transcription factor binding|negative regulation of transcription from RNA polymerase II promoter during mitosis|regulation of cell cycle G1/S phase transition|androgen receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|regulation of transcription from RNA polymerase I promoter|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|negative regulation of cell cycle G1/S phase transition|rRNA transcription|androgen receptor binding|ATPase activity|enhancer binding|positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|response to glucose|glucose mediated signaling pathway|core promoter proximal region DNA binding|helicase activity|ATP-dependent chromatin remodeling|RNA polymerase I regulatory region DNA binding|core promoter sequence-specific DNA binding|ATPase activity, coupled|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|enhancer sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|DNA-dependent ATPase activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 19:10961001-11065395 547 555 854 3072 3451 2640 2.5141703124588 2.31835497586364 3.53898990836679 12.6510356822981 13.0142764019745 11.3720837571996 2.79050506556308 12.3457986138241 -2.14542199284114 2.61735438763833e-22 2.70375425219912e-20 DOWN ENSG00000103671 TRIP4 thyroid hormone receptor interactor 4 [Source:HGNC Symbol;Acc:HGNC:12310] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:0006810|GO:1901360|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0009725|GO:0044249|GO:0010033|GO:0031323|GO:0003713|GO:0016922|GO:0005829|GO:0010468|GO:0034645|GO:1901998|GO:0046872|GO:0033993|GO:0051427|GO:0035035|GO:0051252|GO:0005815|GO:0010628|GO:0002020|GO:0031981|GO:0005654|GO:0014070|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0009755|GO:0016070|GO:0032870|GO:0005856|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0044389|GO:0043401|GO:0045893|GO:0032774|GO:2001141|GO:0035257|GO:0071383|GO:0071407|GO:0030518|GO:0015630|GO:0046914|GO:0071396|GO:0006351|GO:0006355|GO:0030520|GO:0006366|GO:0035258|GO:1903506|GO:0008270|GO:0030331 signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|response to hormone|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|transcription coactivator activity|ligand-dependent nuclear receptor binding|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|toxin transport|metal ion binding|response to lipid|hormone receptor binding|histone acetyltransferase binding|regulation of RNA metabolic process|microtubule organizing center|positive regulation of gene expression|protease binding|nuclear lumen|nucleoplasm|response to organic cyclic compound|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|ubiquitin-like protein ligase binding|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|microtubule cytoskeleton|transition metal ion binding|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|intracellular estrogen receptor signaling pathway|transcription from RNA polymerase II promoter|steroid hormone receptor binding|regulation of nucleic acid-templated transcription|zinc ion binding|estrogen receptor binding - - - - 15:64387748-64455303 40 52 62 376 361 309 0.512864788802682 0.605934331722243 0.716713019229429 4.31944300225 3.79767232690187 3.7130385942957 0.611837379918118 3.94338464114919 -2.68821428355252 2.76014838501509e-22 2.84142999607726e-20 DOWN ENSG00000107890 ANKRD26 ankyrin repeat domain 26 [Source:HGNC Symbol;Acc:HGNC:29186] GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0005813|GO:0005815|GO:0005856|GO:0015630 cell|binding|intracellular organelle|intracellular|protein binding|centrosome|microtubule organizing center|cytoskeleton|microtubule cytoskeleton - - - - 10:26991914-27100498 53 92 93 487 514 495 0.357972356404563 0.56473138463424 0.566331706751648 2.94714191435403 2.84842891615525 3.13334612178877 0.496345149263484 2.97630565076602 -2.58410709293995 3.08183149288797e-22 3.16168375906108e-20 DOWN ENSG00000152061 RABGAP1L RAB GTPase activating protein 1-like [Source:HGNC Symbol;Acc:HGNC:24663] GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0043229|GO:0043227|GO:0009893|GO:0031224|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0008047|GO:0043231|GO:0019899|GO:0005737|GO:0032880|GO:0043085|GO:0008104|GO:0050790|GO:0016021|GO:0005794|GO:0005768|GO:0005096|GO:0051345|GO:0005769|GO:0030695|GO:0051020|GO:0005634|GO:0043087|GO:0043547|GO:0031267|GO:0017016|GO:0017137 cell|membrane|metabolic process|binding|intracellular organelle|membrane-bounded organelle|positive regulation of metabolic process|intrinsic component of membrane|enzyme regulator activity|intracellular|protein binding|endomembrane system|regulation of metabolic process|enzyme activator activity|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of protein localization|positive regulation of catalytic activity|protein localization|regulation of catalytic activity|integral component of membrane|Golgi apparatus|endosome|GTPase activator activity|positive regulation of hydrolase activity|early endosome|GTPase regulator activity|GTPase binding|nucleus|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase binding|Ras GTPase binding|Rab GTPase binding - - - - 1:174159410-174995308 175 133 243 1050 1017 931 0.450503556808884 0.311166809854215 0.56400148376527 2.42185206709931 2.14807647217606 2.24615276909527 0.441890616809456 2.27202710279021 -2.36221884264581 3.24255083103499e-22 3.31517508594927e-20 DOWN ENSG00000214820 MPRIPP1 myosin phosphatase Rho interacting protein pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44594] - - - - - - 3:44579938-44581026 1 2 2 63 62 69 0.0649831895524461 0.118066670484976 0.117131408625736 3.66651369944947 3.3042707381163 4.20044129023486 0.100060422887719 3.72374190926688 -5.2178097240083 3.31450538616689e-22 3.37717555626711e-20 DOWN ENSG00000025293 PHF20 PHD finger protein 20 [Source:HGNC Symbol;Acc:HGNC:16098] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0016746|GO:0005737|GO:0005635|GO:0006139|GO:0031965|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0051252|GO:0006325|GO:0016573|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0016747|GO:0044267|GO:0010467|GO:0000123|GO:0009059|GO:0035097|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0043967|GO:0016407|GO:0016410|GO:0046914|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:1903506|GO:0018193|GO:0043984|GO:0008080|GO:0043981|GO:0043982|GO:0071339|GO:0008270|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402|GO:0010485|GO:0043995|GO:0043996|GO:0046972 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|cytoplasm|nuclear envelope|nucleobase-containing compound metabolic process|nuclear membrane|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|regulation of RNA metabolic process|chromatin organization|histone acetylation|protein modification process|nuclear lumen|transferase complex|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein metabolic process|gene expression|histone acetyltransferase complex|macromolecule biosynthetic process|histone methyltransferase complex|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|histone H4 acetylation|acetyltransferase activity|N-acyltransferase activity|transition metal ion binding|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone H4-K16 acetylation|N-acetyltransferase activity|histone H4-K5 acetylation|histone H4-K8 acetylation|MLL1 complex|zinc ion binding|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity|H4 histone acetyltransferase activity|histone acetyltransferase activity (H4-K5 specific)|histone acetyltransferase activity (H4-K8 specific)|histone acetyltransferase activity (H4-K16 specific) - - - - 20:35771974-35950381 172 198 297 1009 1104 1073 1.08982167463494 1.14017250193978 1.69666614388847 5.72815588679619 5.73935305365755 6.37169118753068 1.30888677348773 5.94640004266147 -2.18367622252388 3.39317717368588e-22 3.44557521575572e-20 DOWN ENSG00000198373 WWP2 WW domain containing E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:16804] GO:0040011|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0000988|GO:0003824|GO:1903561|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0051051|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0016032|GO:0042391|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0001076|GO:0032880|GO:0045184|GO:0009890|GO:0006139|GO:0008104|GO:0044092|GO:0055085|GO:0070062|GO:0008134|GO:0019787|GO:0071804|GO:0032410|GO:0000151|GO:0044249|GO:0019538|GO:0051224|GO:0031324|GO:0031323|GO:0051090|GO:0051701|GO:0010468|GO:0034645|GO:0043412|GO:0030163|GO:0001085|GO:0010629|GO:0004842|GO:0051252|GO:0051223|GO:0015031|GO:0044265|GO:0010628|GO:0036211|GO:0070201|GO:0006811|GO:1990234|GO:0006508|GO:0034765|GO:0043433|GO:0043269|GO:0044267|GO:0010467|GO:0019058|GO:0031328|GO:0071805|GO:0009059|GO:0001191|GO:0016070|GO:0010557|GO:0005634|GO:0022898|GO:0034220|GO:0044257|GO:0045893|GO:0098655|GO:1901379|GO:0061630|GO:0010498|GO:0045892|GO:0046718|GO:0032774|GO:0006812|GO:2001141|GO:1902679|GO:0032412|GO:0051603|GO:0030260|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1901016|GO:1903507|GO:0006357|GO:0043266|GO:0019941|GO:1903506|GO:0001190|GO:0030001|GO:0000122|GO:0015672|GO:0043161|GO:0032446|GO:0006511|GO:0006813|GO:0042787|GO:0016567|GO:0051865|GO:0000209|GO:0070534 locomotion|macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|transcription factor activity, protein binding|catalytic activity|extracellular vesicle|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|negative regulation of transport|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|ligase activity|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|viral process|regulation of membrane potential|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|transcription factor activity, RNA polymerase II transcription factor binding|regulation of protein localization|establishment of protein localization|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|protein localization|negative regulation of molecular function|transmembrane transport|extracellular exosome|transcription factor binding|ubiquitin-like protein transferase activity|cellular potassium ion transport|negative regulation of transporter activity|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|interaction with host|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|protein catabolic process|RNA polymerase II transcription factor binding|negative regulation of gene expression|ubiquitin-protein transferase activity|regulation of RNA metabolic process|regulation of protein transport|protein transport|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|regulation of establishment of protein localization|ion transport|transferase complex|proteolysis|regulation of ion transmembrane transport|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of ion transport|cellular protein metabolic process|gene expression|viral life cycle|positive regulation of cellular biosynthetic process|potassium ion transmembrane transport|macromolecule biosynthetic process|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of transmembrane transporter activity|ion transmembrane transport|cellular protein catabolic process|positive regulation of transcription, DNA-templated|cation transmembrane transport|regulation of potassium ion transmembrane transport|ubiquitin protein ligase activity|proteasomal protein catabolic process|negative regulation of transcription, DNA-templated|viral entry into host cell|RNA biosynthetic process|cation transport|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of ion transmembrane transporter activity|proteolysis involved in cellular protein catabolic process|entry into host cell|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of potassium ion transmembrane transporter activity|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of potassium ion transport|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|transcriptional activator activity, RNA polymerase II transcription factor binding|metal ion transport|negative regulation of transcription from RNA polymerase II promoter|monovalent inorganic cation transport|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|potassium ion transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein autoubiquitination|protein polyubiquitination|protein K63-linked ubiquitination K05630 atrophin-1 interacting protein 2 (WW domain containing E3 ubiquitin protein ligase 2)[2.3.2.26] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 16:69762306-69941741 122 120 156 670 746 611 0.576710254301626 0.515535702318119 0.664869628312774 2.83772792341047 2.89337427850644 2.70687434053827 0.585705194977506 2.81265884748506 -2.26368798039332 3.50514383459158e-22 3.54720556060668e-20 DOWN ENSG00000133131 MORC4 MORC family CW-type zinc finger 4 [Source:HGNC Symbol;Acc:HGNC:23485] GO:0005623|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0043169|GO:0046872|GO:0031981|GO:0005654|GO:0005634|GO:0046914|GO:0008270 cell|binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cation binding|metal ion binding|nuclear lumen|nucleoplasm|nucleus|transition metal ion binding|zinc ion binding - - - - X:106813871-107000244 28 36 32 215 276 270 0.26928701883039 0.314662525471992 0.277475311426389 1.85267198149274 2.17791085965441 2.43363804051621 0.287141618576257 2.15474029388779 -2.90767963854052 3.80483432898313e-22 3.83748392086021e-20 DOWN ENSG00000223612 RP11-289I10.2 - - - - - - - 1:145233001-145233519 73 63 107 468 517 538 9.94948363879998 7.80371956770568 13.1485254195838 57.1506996697609 57.8145040468171 68.7210868694375 10.3005762086965 61.2287635286718 -2.57148450593481 3.95862873793647e-22 3.97915496102206e-20 DOWN ENSG00000101333 PLCB4 phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGNC:9059] GO:0004871|GO:0045202|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0050794|GO:0060076|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0051051|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0043647|GO:0016788|GO:0044281|GO:0019637|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0043005|GO:0036477|GO:0014069|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0043271|GO:0005829|GO:0046872|GO:0043267|GO:0016042|GO:0006066|GO:0005790|GO:0006811|GO:0030425|GO:0043269|GO:0019900|GO:0016298|GO:0006796|GO:0035556|GO:0005634|GO:0042578|GO:0004620|GO:0008081|GO:0006812|GO:0005509|GO:0019901|GO:0004629|GO:0043266|GO:0051019|GO:0030001|GO:0015672|GO:0006813|GO:0004435 signal transducer activity|synapse|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|regulation of cellular process|excitatory synapse|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|negative regulation of transport|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|endomembrane system|transport|inositol phosphate metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|neuron projection|somatodendritic compartment|postsynaptic density|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|negative regulation of ion transport|cytosol|metal ion binding|negative regulation of potassium ion transport|lipid catabolic process|alcohol metabolic process|smooth endoplasmic reticulum|ion transport|dendrite|regulation of ion transport|kinase binding|lipase activity|phosphate-containing compound metabolic process|intracellular signal transduction|nucleus|phosphoric ester hydrolase activity|phospholipase activity|phosphoric diester hydrolase activity|cation transport|calcium ion binding|protein kinase binding|phospholipase C activity|regulation of potassium ion transport|mitogen-activated protein kinase binding|metal ion transport|monovalent inorganic cation transport|potassium ion transport|phosphatidylinositol phospholipase C activity K05858 phosphatidylinositol phospholipase C, beta[3.1.4.11] hsa01100|hsa05200|hsa04015|hsa05016|hsa04062|hsa04020|hsa05010|hsa04022|hsa04921|hsa04261|hsa04072|hsa04310|hsa04728|hsa04611|hsa04270|hsa04071|hsa04919|hsa04724|hsa04726|hsa04725|hsa05142|hsa04933|hsa04922|hsa04723|hsa04916|hsa04915|hsa04750|hsa04070|hsa05146|hsa04972|hsa04713|hsa04912|hsa04970|hsa04540|hsa04911|hsa04925|hsa04971|hsa00562|hsa04918|hsa04720|hsa04924|hsa04730|hsa04961|hsa05143 Metabolic pathways - Homo sapiens (human)|Pathways in cancer - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Renin secretion - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)|African trypanosomiasis - Homo sapiens (human) 20:9068763-9481242 26 36 62 338 352 325 0.182074932937451 0.229120173729977 0.391456858438646 2.12078238597937 2.02251476731553 2.13301127455437 0.267550655035358 2.09210280928309 -2.96706978351359 3.98504442713656e-22 3.99226564858171e-20 DOWN ENSG00000162599 NFIA nuclear factor I/A [Source:HGNC Symbol;Acc:HGNC:7784] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0016032|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0009890|GO:0003682|GO:0006139|GO:0050808|GO:0008134|GO:0044249|GO:0031324|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0006259|GO:0010467|GO:0019079|GO:0007399|GO:0019058|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0060074|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0006260|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:1902679|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|cell|cellular process|metabolic process|cell junction|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|synapse organization|transcription factor binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|DNA metabolic process|gene expression|viral genome replication|nervous system development|viral life cycle|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|synapse maturation|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|DNA replication|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 1:60865259-61462793 15 10 36 234 274 291 0.0594851474293281 0.0360415440259402 0.128718008831527 0.831451845282444 0.891543759541315 1.08154675530805 0.0747482334289318 0.93484745337727 -3.6446195792578 4.30487192212791e-22 4.29824904224771e-20 DOWN ENSG00000148082 SHC3 SHC (Src homology 2 domain containing) transforming protein 3 [Source:HGNC Symbol;Acc:HGNC:18181] GO:0040011|GO:0032502|GO:0004871|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0044708|GO:0071944|GO:0009605|GO:0009893|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0006935|GO:0045087|GO:0048468|GO:0007275|GO:0050877|GO:0005102|GO:0006952|GO:0031325|GO:0019899|GO:0010243|GO:0005737|GO:0007267|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0009725|GO:0007611|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007166|GO:0043412|GO:0007417|GO:1901652|GO:0000904|GO:0071417|GO:0030971|GO:0051347|GO:0036211|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0019900|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0050890|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:1901653|GO:0043408|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0007167|GO:0071375|GO:0043410|GO:0032868|GO:0019901|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:1990782|GO:0001934|GO:0042327|GO:0007268|GO:0007169|GO:0048010|GO:0007270|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0035249 locomotion|developmental process|signal transducer activity|immune system process|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|single-organism behavior|cell periphery|response to external stimulus|positive regulation of metabolic process|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|chemotaxis|innate immune response|cell development|multicellular organism development|neurological system process|receptor binding|defense response|positive regulation of cellular metabolic process|enzyme binding|response to organonitrogen compound|cytoplasm|cell-cell signaling|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|response to hormone|learning or memory|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|cell surface receptor signaling pathway|macromolecule modification|central nervous system development|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|receptor tyrosine kinase binding|positive regulation of transferase activity|protein modification process|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|cognition|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular response to peptide|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|response to insulin|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|protein tyrosine kinase binding|positive regulation of protein phosphorylation|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|neuron-neuron synaptic transmission|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|synaptic transmission, glutamatergic K17448 SHC- transforming protein 3[-] hsa04014|hsa04510|hsa04062|hsa05034|hsa04072|hsa04910|hsa04650|hsa04722|hsa04915|hsa04012|hsa05100|hsa05220|hsa04917|hsa05214 Ras signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Glioma - Homo sapiens (human) 9:89005771-89178767 53 67 96 414 472 526 0.373373617032665 0.42896919270546 0.609755950102283 2.61316356182262 2.72821299319111 3.47282881258885 0.470699586613469 2.93806845586753 -2.64198951941668 4.43262981325122e-22 4.4110576814934e-20 DOWN ENSG00000077585 GPR137B G protein-coupled receptor 137B [Source:HGNC Symbol;Acc:HGNC:11862] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0031090|GO:0005887|GO:0043231|GO:0005774|GO:0005737|GO:0031226|GO:0016021|GO:0005773|GO:0000323|GO:0005765|GO:0005764 cell|membrane|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|organelle membrane|integral component of plasma membrane|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|intrinsic component of plasma membrane|integral component of membrane|vacuole|lytic vacuole|lysosomal membrane|lysosome - - - - 1:236142505-236221865 58 58 112 526 537 757 1.02517377157428 0.931700030131442 1.7848429731561 8.33012852158377 7.78772340325956 12.5398763722435 1.24723892495394 9.55257609902894 -2.93715198684661 4.49238048932683e-22 4.45566535310177e-20 DOWN ENSG00000132383 RPA1 replication protein A1 [Source:HGNC Symbol;Acc:HGNC:10289] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0051606|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0042769|GO:0046483|GO:0033554|GO:0043231|GO:0000723|GO:0043169|GO:0009408|GO:0042592|GO:0019725|GO:0006139|GO:0005662|GO:0044249|GO:0009266|GO:0019538|GO:0006996|GO:1900034|GO:0051276|GO:0003677|GO:0034645|GO:0046872|GO:0000725|GO:0010833|GO:1903047|GO:0043412|GO:0019985|GO:0000722|GO:0044770|GO:0006284|GO:0006302|GO:0036211|GO:0033260|GO:0000278|GO:0036297|GO:0005657|GO:0031981|GO:0034605|GO:0006298|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0032201|GO:0006301|GO:0044267|GO:0009059|GO:0006289|GO:0005634|GO:0006974|GO:0000724|GO:0032200|GO:0006260|GO:0043596|GO:0000781|GO:0003697|GO:0006297|GO:0044772|GO:0070987|GO:0022616|GO:0006283|GO:0016604|GO:0003684|GO:0070911|GO:0006310|GO:0000784|GO:0033683|GO:0090305|GO:0042276|GO:0006464|GO:0071897|GO:0006271|GO:0006261|GO:0018193|GO:0006312|GO:0016605|GO:0000082|GO:0043687|GO:0032446|GO:0018205|GO:0016925 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|detection of stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|DNA damage response, detection of DNA damage|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|telomere maintenance|cation binding|response to heat|homeostatic process|cellular homeostasis|nucleobase-containing compound metabolic process|DNA replication factor A complex|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|organelle organization|regulation of cellular response to heat|chromosome organization|DNA binding|cellular macromolecule biosynthetic process|metal ion binding|recombinational repair|telomere maintenance via telomere lengthening|mitotic cell cycle process|macromolecule modification|translesion synthesis|telomere maintenance via recombination|cell cycle phase transition|base-excision repair|double-strand break repair|protein modification process|nuclear DNA replication|mitotic cell cycle|interstrand cross-link repair|replication fork|nuclear lumen|cellular response to heat|mismatch repair|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|telomere maintenance via semi-conservative replication|postreplication repair|cellular protein metabolic process|macromolecule biosynthetic process|nucleotide-excision repair|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|telomere organization|DNA replication|nuclear replication fork|chromosome, telomeric region|single-stranded DNA binding|nucleotide-excision repair, DNA gap filling|mitotic cell cycle phase transition|error-free translesion synthesis|DNA strand elongation|transcription-coupled nucleotide-excision repair|nuclear body|damaged DNA binding|global genome nucleotide-excision repair|DNA recombination|nuclear chromosome, telomeric region|nucleotide-excision repair, DNA incision|nucleic acid phosphodiester bond hydrolysis|error-prone translesion synthesis|cellular protein modification process|DNA biosynthetic process|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication|peptidyl-amino acid modification|mitotic recombination|PML body|G1/S transition of mitotic cell cycle|post-translational protein modification|protein modification by small protein conjugation|peptidyl-lysine modification|protein sumoylation K07466 replication factor A1[-] hsa03460|hsa03420|hsa03030|hsa03440|hsa03430 Fanconi anemia pathway - Homo sapiens (human)|Nucleotide excision repair - Homo sapiens (human)|DNA replication - Homo sapiens (human)|Homologous recombination - Homo sapiens (human)|Mismatch repair - Homo sapiens (human) 17:1829702-1900082 715 806 1018 3703 4060 3128 5.67896359438849 5.81805819953354 7.28996050121389 26.3520523920864 26.4579983730618 23.2840593108467 6.26232743171197 25.364703358665 -2.0180514399491 4.50857445798419e-22 4.45691992942583e-20 DOWN ENSG00000164597 COG5 component of oligomeric golgi complex 5 [Source:HGNC Symbol;Acc:HGNC:14857] GO:0032991|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0051649|GO:0017119|GO:0005794|GO:0016192|GO:0005829|GO:0015031|GO:0046907|GO:0031981|GO:0005654|GO:0000139|GO:0005634|GO:0048193|GO:0006891 macromolecular complex|cell|membrane|binding|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|establishment of localization in cell|Golgi transport complex|Golgi apparatus|vesicle-mediated transport|cytosol|protein transport|intracellular transport|nuclear lumen|nucleoplasm|Golgi membrane|nucleus|Golgi vesicle transport|intra-Golgi vesicle-mediated transport - - - - 7:107201555-107564514 99 117 213 898 824 1045 0.627839421385905 0.674345057191053 1.21789115647789 5.10257146266597 4.28756199127085 6.21098058813115 0.840025211684949 5.20037134735599 -2.63011011341413 4.81759003112674e-22 4.74667764981049e-20 DOWN ENSG00000170776 AKAP13 A-kinase anchoring protein 13 [Source:HGNC Symbol;Acc:HGNC:371] GO:0004871|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0032947|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0016740|GO:0005085|GO:0019222|GO:0006810|GO:0010941|GO:0016772|GO:0010942|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0051018|GO:0005088|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0051649|GO:0009725|GO:0008219|GO:0050790|GO:0019538|GO:0010033|GO:0031323|GO:0032268|GO:0005829|GO:1900169|GO:0046872|GO:0007166|GO:0033993|GO:0043412|GO:0051345|GO:0090257|GO:0036211|GO:0046907|GO:0048471|GO:0070848|GO:0016301|GO:0012501|GO:0014070|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010611|GO:0014896|GO:0071310|GO:0051246|GO:0051020|GO:0009755|GO:0005089|GO:0043068|GO:1902531|GO:0016773|GO:0032870|GO:0005634|GO:0043067|GO:0048545|GO:0097190|GO:0043401|GO:0043065|GO:0051169|GO:0071363|GO:0043087|GO:0016310|GO:0038179|GO:0071383|GO:0071407|GO:0043547|GO:0007167|GO:0031267|GO:0042981|GO:0004672|GO:0051056|GO:0007264|GO:0006464|GO:0071396|GO:0031960|GO:0043549|GO:0006915|GO:0048011|GO:0003300|GO:0051384|GO:0007265|GO:0006913|GO:0046578|GO:0045859|GO:0017016|GO:0006468|GO:0042325|GO:0001932|GO:0004674|GO:0071384|GO:0043402|GO:0007169|GO:0071385|GO:0017048|GO:0051168|GO:0035023|GO:0007266|GO:0004691 signal transducer activity|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|protein complex scaffold|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|transferase activity|guanyl-nucleotide exchange factor activity|regulation of metabolic process|transport|regulation of cell death|transferase activity, transferring phosphorus-containing groups|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|muscle system process|protein kinase A binding|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|establishment of localization in cell|response to hormone|cell death|regulation of catalytic activity|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of glucocorticoid mediated signaling pathway|metal ion binding|cell surface receptor signaling pathway|response to lipid|macromolecule modification|positive regulation of hydrolase activity|regulation of muscle system process|protein modification process|intracellular transport|perinuclear region of cytoplasm|response to growth factor|kinase activity|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of cardiac muscle hypertrophy|muscle hypertrophy|cellular response to organic substance|regulation of protein metabolic process|GTPase binding|hormone-mediated signaling pathway|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|nucleus|regulation of programmed cell death|response to steroid hormone|apoptotic signaling pathway|steroid hormone mediated signaling pathway|positive regulation of apoptotic process|nuclear transport|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|neurotrophin signaling pathway|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|small GTPase binding|regulation of apoptotic process|protein kinase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|cellular protein modification process|cellular response to lipid|response to corticosteroid|regulation of kinase activity|apoptotic process|neurotrophin TRK receptor signaling pathway|cardiac muscle hypertrophy|response to glucocorticoid|Ras protein signal transduction|nucleocytoplasmic transport|regulation of Ras protein signal transduction|regulation of protein kinase activity|Ras GTPase binding|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|protein serine/threonine kinase activity|cellular response to corticosteroid stimulus|glucocorticoid mediated signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|cellular response to glucocorticoid stimulus|Rho GTPase binding|nuclear export|regulation of Rho protein signal transduction|Rho protein signal transduction|cAMP-dependent protein kinase activity - - - - 15:85380571-85749358 289 319 422 1322 1677 1617 0.668791849896251 0.670909143451468 0.880481252955008 2.74108240733162 3.18415320193936 3.5069689199168 0.740060748767576 3.14406817639593 -2.08691689547349 5.02709060642428e-22 4.93680141329574e-20 DOWN ENSG00000100997 ABHD12 abhydrolase domain containing 12 [Source:HGNC Symbol;Acc:HGNC:15868] GO:0032991|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0044708|GO:0071944|GO:0009605|GO:0016787|GO:0031224|GO:0005886|GO:0043234|GO:0007626|GO:0006575|GO:0044255|GO:0050817|GO:0008344|GO:0030534|GO:0009612|GO:0006082|GO:0098797|GO:0016788|GO:0044281|GO:0019637|GO:0005887|GO:0006520|GO:0009611|GO:0043235|GO:0001775|GO:0031226|GO:1902495|GO:0006629|GO:0016021|GO:0050878|GO:0008328|GO:0006658|GO:0030168|GO:0046486|GO:0016042|GO:0007596|GO:0044242|GO:0007628|GO:0042060|GO:0006638|GO:0009063|GO:0007599|GO:0034702|GO:0016298|GO:0006796|GO:0010996|GO:0042219|GO:0046434|GO:0052689|GO:0006644|GO:0009395|GO:0047372|GO:0046395|GO:0046461|GO:0032281|GO:0019752|GO:0006639|GO:0006650|GO:0006660|GO:0046464|GO:0046475 macromolecular complex|behavior|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|single-organism behavior|cell periphery|response to external stimulus|hydrolase activity|intrinsic component of membrane|plasma membrane|protein complex|locomotory behavior|cellular modified amino acid metabolic process|cellular lipid metabolic process|coagulation|adult locomotory behavior|adult behavior|response to mechanical stimulus|organic acid metabolic process|plasma membrane protein complex|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|integral component of plasma membrane|cellular amino acid metabolic process|response to wounding|receptor complex|cell activation|intrinsic component of plasma membrane|transmembrane transporter complex|lipid metabolic process|integral component of membrane|regulation of body fluid levels|ionotropic glutamate receptor complex|phosphatidylserine metabolic process|platelet activation|glycerolipid metabolic process|lipid catabolic process|blood coagulation|cellular lipid catabolic process|adult walking behavior|wound healing|neutral lipid metabolic process|cellular amino acid catabolic process|hemostasis|ion channel complex|lipase activity|phosphate-containing compound metabolic process|response to auditory stimulus|cellular modified amino acid catabolic process|organophosphate catabolic process|carboxylic ester hydrolase activity|phospholipid metabolic process|phospholipid catabolic process|acylglycerol lipase activity|carboxylic acid catabolic process|neutral lipid catabolic process|AMPA glutamate receptor complex|carboxylic acid metabolic process|acylglycerol metabolic process|glycerophospholipid metabolic process|phosphatidylserine catabolic process|acylglycerol catabolic process|glycerophospholipid catabolic process - - - - 20:25294743-25390983 273 308 518 1824 1897 1784 4.22933797802435 4.33650657914004 7.23525256366601 25.3181699395383 24.1126586649341 25.9020255777888 5.26703237361013 25.1109513940871 -2.25325445781996 5.50518877543534e-22 5.38858707219169e-20 DOWN ENSG00000106049 HIBADH 3-hydroxyisobutyrate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:4907] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0048037|GO:0005622|GO:0006082|GO:0034641|GO:0044281|GO:0016614|GO:0043231|GO:0005737|GO:0006520|GO:0050662|GO:0000166|GO:0055114|GO:0009081|GO:0016616|GO:0009063|GO:0005759|GO:0005739|GO:0051287|GO:0009083|GO:0046395|GO:0006573|GO:0008442|GO:0004616|GO:0019752|GO:0006574 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|cofactor binding|intracellular|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|coenzyme binding|nucleotide binding|oxidation-reduction process|branched-chain amino acid metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|cellular amino acid catabolic process|mitochondrial matrix|mitochondrion|NAD binding|branched-chain amino acid catabolic process|carboxylic acid catabolic process|valine metabolic process|3-hydroxyisobutyrate dehydrogenase activity|phosphogluconate dehydrogenase (decarboxylating) activity|carboxylic acid metabolic process|valine catabolic process K00020 3-hydroxyisobutyrate dehydrogenase[1.1.1.31] hsa01100|hsa00280 Metabolic pathways - Homo sapiens (human)|Valine, leucine and isoleucine degradation - Homo sapiens (human) 7:27525442-27662995 200 253 398 1345 1417 1476 3.61455677034287 4.15552321171754 6.48518068757144 21.7793544955944 21.0117734652093 25.0000076883193 4.75175355654395 22.5970452163743 -2.24960221884455 5.6950444491965e-22 5.55620447667687e-20 DOWN ENSG00000102053 ZC3H12B zinc finger CCCH-type containing 12B [Source:HGNC Symbol;Acc:HGNC:17407] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0006725|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0043169|GO:0006139|GO:0046872|GO:0004518|GO:0004519|GO:0090305 cellular process|metabolic process|binding|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cation binding|nucleobase-containing compound metabolic process|metal ion binding|nuclease activity|endonuclease activity|nucleic acid phosphodiester bond hydrolysis - - - - X:65366638-65507887 9 15 19 129 178 183 0.0728498909495291 0.11034900513147 0.13865998555449 0.935558010564993 1.18214660328949 1.38824153480161 0.107286293878496 1.1686487162187 -3.44530365105855 6.09398829170005e-22 5.92605623649555e-20 DOWN ENSG00000185022 MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F [Source:HGNC Symbol;Acc:HGNC:6780] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0050817|GO:0045595|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0061061|GO:0043231|GO:0005737|GO:0000981|GO:0009611|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0050878|GO:0007567|GO:0003677|GO:0045682|GO:0010468|GO:0034645|GO:0007596|GO:0051252|GO:0009790|GO:0010628|GO:0030856|GO:0060537|GO:0042060|GO:0031981|GO:0007599|GO:0005654|GO:0005739|GO:0060429|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0007517|GO:0016070|GO:0010557|GO:0005634|GO:0060538|GO:0045893|GO:0009792|GO:0030855|GO:0032774|GO:0043565|GO:2001141|GO:0008544|GO:0045604|GO:0035914|GO:0014706|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0007519|GO:1903506|GO:0043009|GO:0009913|GO:0001701 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|coagulation|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|response to wounding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of body fluid levels|parturition|DNA binding|regulation of epidermis development|regulation of gene expression|cellular macromolecule biosynthetic process|blood coagulation|regulation of RNA metabolic process|embryo development|positive regulation of gene expression|regulation of epithelial cell differentiation|muscle tissue development|wound healing|nuclear lumen|hemostasis|nucleoplasm|mitochondrion|epithelium development|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|muscle organ development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|skeletal muscle organ development|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|epithelial cell differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|epidermis development|regulation of epidermal cell differentiation|skeletal muscle cell differentiation|striated muscle tissue development|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|chordate embryonic development|epidermal cell differentiation|in utero embryonic development - - - - 22:38200767-38216511 2868 2948 2746 711 895 806 16.9811055151989 15.8633305370687 14.6589095082381 3.77184895165953 4.34788263558276 4.47250438316975 15.8344485201686 4.19741199013735 1.91549464160314 6.43607175708404e-22 6.23839241025932e-20 UP ENSG00000145246 ATP10D ATPase, class V, type 10D [Source:HGNC Symbol;Acc:HGNC:13549] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0042175|GO:0043167|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0097035|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0005319|GO:0055085|GO:0061024|GO:0005783|GO:0000166|GO:0016021|GO:0010876|GO:0046872|GO:0035639|GO:0005548|GO:0001883|GO:0016818|GO:0006811|GO:0032549|GO:0031981|GO:0006869|GO:0005654|GO:0017076|GO:0005634|GO:0034220|GO:0015914|GO:0045332|GO:0006820|GO:0015711|GO:0000287|GO:0005524|GO:0006812|GO:0030554|GO:0004012|GO:0016462|GO:0017111|GO:0016887|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of membrane lipid distribution|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|lipid transporter activity|transmembrane transport|membrane organization|endoplasmic reticulum|nucleotide binding|integral component of membrane|lipid localization|metal ion binding|purine ribonucleoside triphosphate binding|phospholipid transporter activity|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|ribonucleoside binding|nuclear lumen|lipid transport|nucleoplasm|purine nucleotide binding|nucleus|ion transmembrane transport|phospholipid transport|phospholipid translocation|anion transport|organic anion transport|magnesium ion binding|ATP binding|cation transport|adenyl nucleotide binding|phospholipid-translocating ATPase activity|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|ATPase activity, coupled|ATPase activity, coupled to movement of substances - - - - 4:47485288-47593486 110 131 203 754 787 887 0.656460240364688 0.710509322282626 1.09226165860013 4.03168479796273 3.85354399490399 4.96101074907856 0.819743740415815 4.28207984731509 -2.38506681238038 6.95662008205834e-22 6.7211306126139e-20 DOWN ENSG00000131089 ARHGEF9 Cdc42 guanine nucleotide exchange factor 9 [Source:HGNC Symbol;Acc:HGNC:14561] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0019222|GO:0006810|GO:0010941|GO:0010942|GO:0005737|GO:0007267|GO:0005088|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0055085|GO:0007165|GO:0008219|GO:0050790|GO:0010033|GO:0005829|GO:0007166|GO:0051345|GO:0006811|GO:0070848|GO:0012501|GO:0035556|GO:0071310|GO:0005089|GO:0043068|GO:1902531|GO:0043067|GO:0097190|GO:0034220|GO:0043065|GO:0071363|GO:0043087|GO:0038179|GO:0043547|GO:0007167|GO:0042981|GO:0051056|GO:0007264|GO:0006915|GO:0048011|GO:0007265|GO:0046578|GO:0007268|GO:0007169|GO:0035023|GO:0007266 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|transport|regulation of cell death|positive regulation of cell death|cytoplasm|cell-cell signaling|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|transmembrane transport|signal transduction|cell death|regulation of catalytic activity|response to organic substance|cytosol|cell surface receptor signaling pathway|positive regulation of hydrolase activity|ion transport|response to growth factor|programmed cell death|intracellular signal transduction|cellular response to organic substance|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|regulation of programmed cell death|apoptotic signaling pathway|ion transmembrane transport|positive regulation of apoptotic process|cellular response to growth factor stimulus|regulation of GTPase activity|neurotrophin signaling pathway|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of apoptotic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|apoptotic process|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction - - - - X:63634967-63809274 141 145 160 724 721 702 0.502186663954887 0.469346418917625 0.513781850161584 2.31036697297514 2.10691865207189 2.34320760009272 0.495104977678032 2.25349774171325 -2.18635964526445 7.06497286577633e-22 6.80379677209311e-20 DOWN ENSG00000109320 NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [Source:HGNC Symbol;Acc:HGNC:7794] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0023051|GO:0051707|GO:0010884|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0019222|GO:0042802|GO:0001818|GO:0002757|GO:0010883|GO:0045087|GO:0045595|GO:0006725|GO:0032369|GO:0006810|GO:0009612|GO:1901360|GO:0010941|GO:0003676|GO:0034641|GO:0044281|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0001817|GO:0033256|GO:0045597|GO:0043231|GO:0010243|GO:0005737|GO:0000981|GO:0002218|GO:0001816|GO:0009611|GO:0005975|GO:1990089|GO:0043005|GO:0009966|GO:0046983|GO:0009890|GO:0003682|GO:0006979|GO:0001819|GO:0060548|GO:0010646|GO:0006139|GO:0009617|GO:0050776|GO:0007154|GO:0044092|GO:0006629|GO:0007165|GO:0050778|GO:0008134|GO:0008092|GO:0009725|GO:0008219|GO:0030656|GO:0019915|GO:0050790|GO:0031072|GO:0045833|GO:0043086|GO:0048869|GO:0010035|GO:0009967|GO:0044249|GO:0010876|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0051090|GO:0042107|GO:0000165|GO:0032268|GO:0030111|GO:0006109|GO:0005829|GO:0003677|GO:0005976|GO:0051354|GO:0009743|GO:0042036|GO:0010468|GO:0034645|GO:0042089|GO:0032479|GO:0007166|GO:0033993|GO:0043412|GO:1990090|GO:0002758|GO:0034097|GO:0010629|GO:0050727|GO:0002237|GO:0043069|GO:0046982|GO:0051252|GO:0006066|GO:0032655|GO:1901652|GO:0010957|GO:0032481|GO:0071417|GO:0010628|GO:0010038|GO:0051055|GO:0032615|GO:0036211|GO:0032269|GO:0043331|GO:0071219|GO:0003705|GO:0010743|GO:0006954|GO:0051091|GO:0042805|GO:0002429|GO:0010744|GO:0043279|GO:0031981|GO:0031098|GO:0032368|GO:0043434|GO:0050728|GO:0042035|GO:0006869|GO:0035994|GO:0032606|GO:0045939|GO:0070848|GO:0006508|GO:0005654|GO:0046688|GO:0005739|GO:0002764|GO:0008202|GO:0051341|GO:0012501|GO:0014070|GO:0006796|GO:0035556|GO:1901137|GO:0044267|GO:0010467|GO:0032695|GO:0008610|GO:0019216|GO:0071310|GO:0001227|GO:1903416|GO:0046890|GO:0031328|GO:0051246|GO:0030177|GO:0071260|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0032870|GO:0010557|GO:0032496|GO:0005634|GO:0016051|GO:0042803|GO:0043067|GO:1900127|GO:0045089|GO:0045088|GO:0006766|GO:0032375|GO:0071322|GO:0016055|GO:0071312|GO:0000975|GO:0045893|GO:0070555|GO:2000628|GO:0045083|GO:1901653|GO:0060828|GO:0045892|GO:0000271|GO:0001205|GO:0038061|GO:0042359|GO:0032774|GO:0043565|GO:0034660|GO:0071359|GO:0019218|GO:2001141|GO:0071363|GO:0016310|GO:0051092|GO:0002768|GO:0033619|GO:0038179|GO:1902679|GO:0002221|GO:0071407|GO:0003690|GO:0006694|GO:1904632|GO:0007167|GO:0010956|GO:0007249|GO:0071375|GO:0050810|GO:0006024|GO:0015918|GO:0035094|GO:0042981|GO:0010894|GO:0071345|GO:0045075|GO:0043066|GO:0034612|GO:0030203|GO:0006464|GO:1990416|GO:0050851|GO:0090263|GO:0071396|GO:0051403|GO:0006351|GO:0060558|GO:2000630|GO:0006915|GO:0006355|GO:0071222|GO:0070741|GO:0032769|GO:0048011|GO:0045944|GO:0006366|GO:0002223|GO:1903507|GO:0002224|GO:0031293|GO:0071347|GO:0006357|GO:0006468|GO:1904630|GO:0071356|GO:1903506|GO:0032374|GO:0044212|GO:0010742|GO:0060070|GO:0071354|GO:0030301|GO:0038093|GO:0071316|GO:0050852|GO:0000122|GO:0030213|GO:0007169|GO:0010586|GO:0035326|GO:0034166|GO:0034134|GO:0030212|GO:0038124|GO:0000976|GO:0001012|GO:0038095|GO:0002756|GO:0034138|GO:0002755|GO:0034146|GO:0034142|GO:0038123|GO:0034162|GO:0000977|GO:0001158|GO:0035666|GO:0000980 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|regulation of signaling|response to other organism|positive regulation of lipid storage|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|protein complex|regulation of metabolic process|identical protein binding|negative regulation of cytokine production|immune response-activating signal transduction|regulation of lipid storage|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|negative regulation of lipid transport|transport|response to mechanical stimulus|organic cyclic compound metabolic process|regulation of cell death|nucleic acid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|regulation of cytokine production|I-kappaB/NF-kappaB complex|positive regulation of cell differentiation|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|cytokine production|response to wounding|carbohydrate metabolic process|response to nerve growth factor|neuron projection|regulation of signal transduction|protein dimerization activity|negative regulation of biosynthetic process|chromatin binding|response to oxidative stress|positive regulation of cytokine production|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|cell communication|negative regulation of molecular function|lipid metabolic process|signal transduction|positive regulation of immune response|transcription factor binding|cytoskeletal protein binding|response to hormone|cell death|regulation of vitamin metabolic process|lipid storage|regulation of catalytic activity|heat shock protein binding|negative regulation of lipid metabolic process|negative regulation of catalytic activity|cellular developmental process|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|cytokine metabolic process|MAPK cascade|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|regulation of carbohydrate metabolic process|cytosol|DNA binding|polysaccharide metabolic process|negative regulation of oxidoreductase activity|response to carbohydrate|negative regulation of cytokine biosynthetic process|regulation of gene expression|cellular macromolecule biosynthetic process|cytokine biosynthetic process|regulation of type I interferon production|cell surface receptor signaling pathway|response to lipid|macromolecule modification|cellular response to nerve growth factor stimulus|innate immune response-activating signal transduction|response to cytokine|negative regulation of gene expression|regulation of inflammatory response|response to molecule of bacterial origin|negative regulation of programmed cell death|protein heterodimerization activity|regulation of RNA metabolic process|alcohol metabolic process|regulation of interleukin-12 production|response to peptide|negative regulation of vitamin D biosynthetic process|positive regulation of type I interferon production|cellular response to organonitrogen compound|positive regulation of gene expression|response to metal ion|negative regulation of lipid biosynthetic process|interleukin-12 production|protein modification process|negative regulation of cellular protein metabolic process|response to dsRNA|cellular response to molecule of bacterial origin|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|regulation of macrophage derived foam cell differentiation|inflammatory response|positive regulation of sequence-specific DNA binding transcription factor activity|actinin binding|immune response-activating cell surface receptor signaling pathway|positive regulation of macrophage derived foam cell differentiation|response to alkaloid|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of lipid transport|response to peptide hormone|negative regulation of inflammatory response|regulation of cytokine biosynthetic process|lipid transport|response to muscle stretch|type I interferon production|negative regulation of steroid metabolic process|response to growth factor|proteolysis|nucleoplasm|response to copper ion|mitochondrion|immune response-regulating signaling pathway|steroid metabolic process|regulation of oxidoreductase activity|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|cellular protein metabolic process|gene expression|negative regulation of interleukin-12 production|lipid biosynthetic process|regulation of lipid metabolic process|cellular response to organic substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|response to glycoside|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|cellular response to mechanical stimulus|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|carbohydrate biosynthetic process|protein homodimerization activity|regulation of programmed cell death|positive regulation of hyaluronan biosynthetic process|positive regulation of innate immune response|regulation of innate immune response|vitamin metabolic process|negative regulation of cholesterol transport|cellular response to carbohydrate stimulus|Wnt signaling pathway|cellular response to alkaloid|regulatory region DNA binding|positive regulation of transcription, DNA-templated|response to interleukin-1|regulation of miRNA metabolic process|negative regulation of interleukin-12 biosynthetic process|cellular response to peptide|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|polysaccharide biosynthetic process|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding|NIK/NF-kappaB signaling|vitamin D metabolic process|RNA biosynthetic process|sequence-specific DNA binding|ncRNA metabolic process|cellular response to dsRNA|regulation of steroid metabolic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|phosphorylation|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|membrane protein proteolysis|neurotrophin signaling pathway|negative regulation of RNA biosynthetic process|pattern recognition receptor signaling pathway|cellular response to organic cyclic compound|double-stranded DNA binding|steroid biosynthetic process|cellular response to glucoside|enzyme linked receptor protein signaling pathway|negative regulation of calcidiol 1-monooxygenase activity|I-kappaB kinase/NF-kappaB signaling|cellular response to peptide hormone stimulus|regulation of steroid biosynthetic process|glycosaminoglycan biosynthetic process|sterol transport|response to nicotine|regulation of apoptotic process|negative regulation of steroid biosynthetic process|cellular response to cytokine stimulus|regulation of interleukin-12 biosynthetic process|negative regulation of apoptotic process|response to tumor necrosis factor|glycosaminoglycan metabolic process|cellular protein modification process|cellular response to brain-derived neurotrophic factor stimulus|antigen receptor-mediated signaling pathway|positive regulation of canonical Wnt signaling pathway|cellular response to lipid|stress-activated MAPK cascade|transcription, DNA-templated|regulation of calcidiol 1-monooxygenase activity|positive regulation of miRNA metabolic process|apoptotic process|regulation of transcription, DNA-templated|cellular response to lipopolysaccharide|response to interleukin-6|negative regulation of monooxygenase activity|neurotrophin TRK receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|stimulatory C-type lectin receptor signaling pathway|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|membrane protein intracellular domain proteolysis|cellular response to interleukin-1|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|cellular response to diterpene|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of cholesterol transport|transcription regulatory region DNA binding|macrophage derived foam cell differentiation|canonical Wnt signaling pathway|cellular response to interleukin-6|cholesterol transport|Fc receptor signaling pathway|cellular response to nicotine|T cell receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|hyaluronan biosynthetic process|transmembrane receptor protein tyrosine kinase signaling pathway|miRNA metabolic process|enhancer binding|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|hyaluronan metabolic process|toll-like receptor TLR6:TLR2 signaling pathway|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|Fc-epsilon receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|RNA polymerase II regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding|TRIF-dependent toll-like receptor signaling pathway|RNA polymerase II distal enhancer sequence-specific DNA binding K02580 nuclear factor NF-kappa-B p105 subunit[-] hsa05200|hsa04151|hsa05166|hsa05206|hsa04010|hsa04014|hsa05203|hsa05169|hsa04024|hsa04062|hsa05168|hsa05202|hsa05152|hsa05164|hsa04932|hsa05161|hsa04210|hsa05162|hsa05160|hsa04380|hsa04722|hsa04071|hsa05145|hsa04668|hsa04931|hsa04620|hsa05142|hsa04660|hsa04066|hsa04933|hsa05146|hsa04211|hsa04064|hsa05215|hsa05132|hsa05222|hsa05133|hsa05220|hsa05140|hsa04662|hsa04917|hsa04920|hsa04622|hsa05120|hsa05212|hsa05131|hsa05321|hsa04623|hsa04621|hsa05221|hsa05134|hsa05030 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Measles - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|RIG-I-like receptor signaling pathway - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|Inflammatory bowel disease (IBD) - Homo sapiens (human)|Cytosolic DNA-sensing pathway - Homo sapiens (human)|NOD-like receptor signaling pathway - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Legionellosis - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human) 4:102501329-102617302 58 60 42 583 641 339 0.397244910325355 0.373473869553076 0.259354321795917 3.57763233584912 3.60209986340669 2.17599616121829 0.343357700558116 3.11857612015803 -3.18310324882394 8.68326449167196e-22 8.33537550271301e-20 DOWN ENSG00000172292 CERS6 ceramide synthase 6 [Source:HGNC Symbol;Acc:HGNC:23826] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0003676|GO:0034641|GO:0044281|GO:0043231|GO:0016746|GO:0005737|GO:0005635|GO:0006629|GO:0005783|GO:0031965|GO:0016021|GO:0044249|GO:0003677|GO:0006665|GO:0006643|GO:0016747|GO:0043603|GO:0008610|GO:0005634|GO:0006672|GO:0016410|GO:0030148|GO:0046513|GO:0050291 cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|nuclear envelope|lipid metabolic process|endoplasmic reticulum|nuclear membrane|integral component of membrane|cellular biosynthetic process|DNA binding|sphingolipid metabolic process|membrane lipid metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|cellular amide metabolic process|lipid biosynthetic process|nucleus|ceramide metabolic process|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|sphingosine N-acyltransferase activity K04710 ceramide synthetase[2.3.1.24] hsa01100|hsa04071|hsa00600 Metabolic pathways - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human) 2:168455862-168775137 126 145 263 937 1030 1116 0.673377644089014 0.704267847244103 1.26724039066458 4.48669078036602 4.51641874682356 5.58961922428124 0.881628627332566 4.86424291715694 -2.46397230235838 8.8686866702214e-22 8.48608243117915e-20 DOWN ENSG00000144468 RHBDD1 rhomboid domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23081] GO:0032502|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0044702|GO:0042175|GO:0071704|GO:0009056|GO:0009628|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0043227|GO:0009893|GO:0032504|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0048609|GO:0019222|GO:0009314|GO:0006810|GO:0010941|GO:0031325|GO:0033554|GO:0043231|GO:0031227|GO:0008233|GO:0005737|GO:0048515|GO:0045184|GO:0060548|GO:0030176|GO:0008104|GO:0007276|GO:0005783|GO:0051649|GO:0008219|GO:0051047|GO:0048869|GO:0016021|GO:0019538|GO:0031301|GO:0010033|GO:0031323|GO:0036503|GO:0017171|GO:0032268|GO:0045732|GO:0010468|GO:0048232|GO:0043412|GO:0030163|GO:0030970|GO:0043069|GO:0051604|GO:0015031|GO:0010628|GO:0036211|GO:0046907|GO:0051046|GO:0006986|GO:0071478|GO:0044322|GO:0051247|GO:0006508|GO:0005739|GO:0034613|GO:0032270|GO:0012501|GO:0008236|GO:0044267|GO:0042176|GO:0010467|GO:0046903|GO:0071310|GO:0051246|GO:0030154|GO:0035967|GO:0034976|GO:0009416|GO:0043067|GO:0034620|GO:0007283|GO:0004252|GO:1903319|GO:0009411|GO:0016485|GO:0032527|GO:0030162|GO:0045862|GO:0033619|GO:0006886|GO:0004175|GO:0071482|GO:0042981|GO:1904211|GO:0043066|GO:0006464|GO:0006915|GO:0010954|GO:0031293|GO:0070613|GO:0043687|GO:0034644 developmental process|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|response to abiotic stimulus|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|response to radiation|transport|regulation of cell death|positive regulation of cellular metabolic process|cellular response to stress|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|peptidase activity|cytoplasm|spermatid differentiation|establishment of protein localization|negative regulation of cell death|integral component of endoplasmic reticulum membrane|protein localization|gamete generation|endoplasmic reticulum|establishment of localization in cell|cell death|positive regulation of secretion|cellular developmental process|integral component of membrane|protein metabolic process|integral component of organelle membrane|response to organic substance|regulation of cellular metabolic process|ERAD pathway|serine hydrolase activity|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|regulation of gene expression|male gamete generation|macromolecule modification|protein catabolic process|retrograde protein transport, ER to cytosol|negative regulation of programmed cell death|protein maturation|protein transport|positive regulation of gene expression|protein modification process|intracellular transport|regulation of secretion|response to unfolded protein|cellular response to radiation|endoplasmic reticulum quality control compartment|positive regulation of protein metabolic process|proteolysis|mitochondrion|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|serine-type peptidase activity|cellular protein metabolic process|regulation of protein catabolic process|gene expression|secretion|cellular response to organic substance|regulation of protein metabolic process|cell differentiation|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|response to light stimulus|regulation of programmed cell death|cellular response to unfolded protein|spermatogenesis|serine-type endopeptidase activity|positive regulation of protein maturation|response to UV|protein processing|protein exit from endoplasmic reticulum|regulation of proteolysis|positive regulation of proteolysis|membrane protein proteolysis|intracellular protein transport|endopeptidase activity|cellular response to light stimulus|regulation of apoptotic process|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol|negative regulation of apoptotic process|cellular protein modification process|apoptotic process|positive regulation of protein processing|membrane protein intracellular domain proteolysis|regulation of protein processing|post-translational protein modification|cellular response to UV - - - - 2:226835581-226999215 72 89 89 429 492 462 0.335955249080704 0.377414268449542 0.374411593457992 1.79349973972674 1.88356109798994 2.02030955051305 0.362593703662746 1.89912346274324 -2.38890792027274 1.06207802831274e-21 1.01301205933701e-19 DOWN ENSG00000108061 SHOC2 SHOC2 leucine-rich repeat scaffold protein [Source:HGNC Symbol;Acc:HGNC:15454] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0008287|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0000164|GO:0019208|GO:0043231|GO:0019899|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0050790|GO:0009967|GO:0010033|GO:0071774|GO:1902533|GO:0007166|GO:0019902|GO:0031981|GO:0044344|GO:0070848|GO:0005654|GO:0035556|GO:0071310|GO:0019888|GO:1902531|GO:0005634|GO:0008543|GO:0071363|GO:0019903|GO:0007167|GO:0051057|GO:0051056|GO:0007264|GO:0007265|GO:0046578|GO:0046579|GO:0008157|GO:0007169 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|protein serine/threonine phosphatase complex|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|protein phosphatase type 1 complex|phosphatase regulator activity|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|regulation of catalytic activity|positive regulation of signal transduction|response to organic substance|response to fibroblast growth factor|positive regulation of intracellular signal transduction|cell surface receptor signaling pathway|phosphatase binding|nuclear lumen|cellular response to fibroblast growth factor stimulus|response to growth factor|nucleoplasm|intracellular signal transduction|cellular response to organic substance|protein phosphatase regulator activity|regulation of intracellular signal transduction|nucleus|fibroblast growth factor receptor signaling pathway|cellular response to growth factor stimulus|protein phosphatase binding|enzyme linked receptor protein signaling pathway|positive regulation of small GTPase mediated signal transduction|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|Ras protein signal transduction|regulation of Ras protein signal transduction|positive regulation of Ras protein signal transduction|protein phosphatase 1 binding|transmembrane receptor protein tyrosine kinase signaling pathway K19613 leucine-rich repeat protein SHOC2[-] hsa04014 Ras signaling pathway - Homo sapiens (human) 10:110919547-111013667 92 81 155 692 716 607 0.643955976249325 0.515268344850831 0.978167864659857 4.33980558925911 4.11194453330457 3.98184490899503 0.712464061920004 4.14453167718624 -2.54031994086192 1.08889477919924e-21 1.03528231650364e-19 DOWN ENSG00000086200 IPO11 importin 11 [Source:HGNC Symbol;Acc:HGNC:20628] GO:0005215|GO:0005623|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0008565|GO:0006810|GO:0043231|GO:0019899|GO:0005737|GO:0005635|GO:0045184|GO:0008104|GO:0051649|GO:0005829|GO:0072594|GO:0015031|GO:0046907|GO:0034613|GO:0017038|GO:0051020|GO:0005634|GO:0006606|GO:0033365|GO:0051169|GO:0006610|GO:0006605|GO:0006886|GO:0031267|GO:0042991|GO:0006913|GO:0017016|GO:0034504|GO:0051170|GO:0008536 transporter activity|cell|binding|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|protein transporter activity|transport|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|nuclear envelope|establishment of protein localization|protein localization|establishment of localization in cell|cytosol|establishment of protein localization to organelle|protein transport|intracellular transport|cellular protein localization|protein import|GTPase binding|nucleus|protein import into nucleus|protein localization to organelle|nuclear transport|ribosomal protein import into nucleus|protein targeting|intracellular protein transport|small GTPase binding|transcription factor import into nucleus|nucleocytoplasmic transport|Ras GTPase binding|protein localization to nucleus|nuclear import|Ran GTPase binding - - - - 5:62403972-62628582 187 206 242 976 1100 816 1.02287393677091 1.02406311694156 1.19346490048579 4.78329695664036 4.93674611996546 4.1831068540254 1.08013398473275 4.63438331021041 -2.1011670926143 1.3628082549024e-21 1.29159611561448e-19 DOWN ENSG00000047578 KIAA0556 KIAA0556 [Source:HGNC Symbol;Acc:HGNC:29068] GO:0005623|GO:0016020|GO:0005576|GO:0043229|GO:0043227|GO:0071944|GO:0005615|GO:0005622|GO:0005886|GO:0043231|GO:0031981|GO:0005654|GO:0005634 cell|membrane|extracellular region|intracellular organelle|membrane-bounded organelle|cell periphery|extracellular space|intracellular|plasma membrane|intracellular membrane-bounded organelle|nuclear lumen|nucleoplasm|nucleus - - - - 16:27550133-27780369 139 157 256 884 948 1033 0.866672185629156 0.889655077220959 1.439116863908 4.9384587286287 4.84972834889841 6.03629599107376 1.06514804225271 5.27482768953362 -2.30807000575846 1.55473432067144e-21 1.46883032940902e-19 DOWN ENSG00000100485 SOS2 SOS Ras/Rho guanine nucleotide exchange factor 2 [Source:HGNC Symbol;Acc:HGNC:11188] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0023051|GO:0009653|GO:0016043|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0048856|GO:0019222|GO:0006935|GO:0048468|GO:0010941|GO:0007275|GO:0003676|GO:0010942|GO:0005737|GO:0005088|GO:0006928|GO:0009966|GO:0046983|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0010033|GO:1902533|GO:0000902|GO:0005829|GO:0031175|GO:0003677|GO:0007166|GO:0051345|GO:0046982|GO:0000904|GO:0070848|GO:0012501|GO:0035556|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0030154|GO:0048858|GO:0005089|GO:0043068|GO:1902531|GO:0043067|GO:0097190|GO:0048666|GO:0030182|GO:0007411|GO:0043065|GO:0071363|GO:0043087|GO:0038179|GO:0061564|GO:0043547|GO:0007167|GO:0042981|GO:0051057|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0048812|GO:0006915|GO:0048011|GO:0007265|GO:0046578|GO:0007409|GO:0048699|GO:0007169|GO:0035023|GO:0007266 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|chemotaxis|cell development|regulation of cell death|multicellular organism development|nucleic acid binding|positive regulation of cell death|cytoplasm|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|regulation of signal transduction|protein dimerization activity|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|response to organic substance|positive regulation of intracellular signal transduction|cell morphogenesis|cytosol|neuron projection development|DNA binding|cell surface receptor signaling pathway|positive regulation of hydrolase activity|protein heterodimerization activity|cell morphogenesis involved in differentiation|response to growth factor|programmed cell death|intracellular signal transduction|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|regulation of programmed cell death|apoptotic signaling pathway|neuron development|neuron differentiation|axon guidance|positive regulation of apoptotic process|cellular response to growth factor stimulus|regulation of GTPase activity|neurotrophin signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of apoptotic process|positive regulation of small GTPase mediated signal transduction|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|neuron projection morphogenesis|apoptotic process|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|axonogenesis|generation of neurons|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction K03099 son of sevenless[-] hsa05200|hsa04151|hsa05206|hsa04010|hsa04014|hsa04810|hsa05205|hsa04510|hsa04062|hsa05034|hsa04630|hsa04072|hsa04910|hsa04650|hsa04068|hsa05160|hsa04722|hsa04660|hsa05231|hsa04915|hsa04912|hsa05215|hsa04540|hsa04012|hsa05220|hsa04662|hsa04917|hsa04664|hsa05211|hsa05214|hsa05221|hsa05223|hsa05213|hsa04320 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Gap junction - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Glioma - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Dorso-ventral axis formation - Homo sapiens (human) 14:50117120-50231558 86 89 164 658 678 738 0.726717412177492 0.683502605387057 1.24947240879776 4.98186482076601 4.7007402781391 5.8445842845587 0.88656414212077 5.17572979448794 -2.54546538387406 1.57394767577383e-21 1.48229129061678e-19 DOWN ENSG00000132640 BTBD3 BTB (POZ) domain containing 3 [Source:HGNC Symbol;Acc:HGNC:15854] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0043229|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0048468|GO:0007275|GO:0048513|GO:0016358|GO:0030900|GO:0007420|GO:0043231|GO:0005737|GO:0060322|GO:0021987|GO:0021543|GO:0030030|GO:0048869|GO:0021537|GO:0000902|GO:0005829|GO:0031175|GO:0007417|GO:0048813|GO:0000904|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0005634|GO:0048666|GO:0030182|GO:0022008|GO:0048667|GO:0048812|GO:0048699 developmental process|cell|cellular process|binding|intracellular organelle|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|cell development|multicellular organism development|animal organ development|dendrite development|forebrain development|brain development|intracellular membrane-bounded organelle|cytoplasm|head development|cerebral cortex development|pallium development|cell projection organization|cellular developmental process|telencephalon development|cell morphogenesis|cytosol|neuron projection development|central nervous system development|dendrite morphogenesis|cell morphogenesis involved in differentiation|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|nucleus|neuron development|neuron differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|generation of neurons - - - - 20:11890723-11926609 56 53 155 819 990 754 0.268488430794628 0.230937876836692 0.670012501033788 3.51817507348288 3.89438643706889 3.38794415111734 0.389812936221703 3.6001685538897 -3.20721057934089 1.60823541073914e-21 1.5098194953524e-19 DOWN ENSG00000047849 MAP4 microtubule associated protein 4 [Source:HGNC Symbol;Acc:HGNC:6862] GO:0032502|GO:0032991|GO:0045202|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0042995|GO:0097159|GO:0044877|GO:0060076|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0007049|GO:0051640|GO:0048468|GO:0022402|GO:0007275|GO:0003676|GO:0005874|GO:0031982|GO:0005737|GO:0006928|GO:0032403|GO:0051656|GO:0043005|GO:0097481|GO:0014069|GO:0005875|GO:0007163|GO:0070062|GO:0051649|GO:0008092|GO:0030030|GO:0051301|GO:0048869|GO:0007017|GO:0006996|GO:0015631|GO:0051653|GO:0031175|GO:0003723|GO:1903047|GO:0007010|GO:0008017|GO:0000278|GO:0030010|GO:0007018|GO:0007051|GO:0051293|GO:0007399|GO:0030154|GO:0000226|GO:0005856|GO:0005819|GO:0048666|GO:0030182|GO:0072686|GO:0051294|GO:0051012|GO:0007052|GO:0015630|GO:0044822|GO:0022008|GO:0048699 developmental process|macromolecular complex|synapse|structural molecule activity|cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|cell projection|organic cyclic compound binding|macromolecular complex binding|excitatory synapse|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cell cycle|organelle localization|cell development|cell cycle process|multicellular organism development|nucleic acid binding|microtubule|vesicle|cytoplasm|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|neuron projection|neuronal postsynaptic density|postsynaptic density|microtubule associated complex|establishment or maintenance of cell polarity|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|cell projection organization|cell division|cellular developmental process|microtubule-based process|organelle organization|tubulin binding|spindle localization|neuron projection development|RNA binding|mitotic cell cycle process|cytoskeleton organization|microtubule binding|mitotic cell cycle|establishment of cell polarity|microtubule-based movement|spindle organization|establishment of spindle localization|nervous system development|cell differentiation|microtubule cytoskeleton organization|cytoskeleton|spindle|neuron development|neuron differentiation|mitotic spindle|establishment of spindle orientation|microtubule sliding|mitotic spindle organization|microtubule cytoskeleton|poly(A) RNA binding|neurogenesis|generation of neurons - - - - 3:47850690-48089272 434 479 941 3398 3713 3390 1.05417979741705 1.05740155623007 2.06076431366646 7.39512711352459 7.39975660123132 7.71708273918773 1.39078188910453 7.50398881798121 -2.43176149264554 1.62775622943478e-21 1.52335531265034e-19 DOWN ENSG00000100065 CARD10 caspase recruitment domain family member 10 [Source:HGNC Symbol;Acc:HGNC:16422] GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0032947|GO:0044237|GO:0023051|GO:0016043|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0010941|GO:0030159|GO:0031325|GO:0022607|GO:0005737|GO:0032449|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0009967|GO:0019538|GO:0031323|GO:1902533|GO:0032268|GO:0043412|GO:0051347|GO:0036211|GO:0051247|GO:0006461|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:1902531|GO:0043067|GO:0031401|GO:0038061|GO:0016310|GO:1901222|GO:0042981|GO:0006464|GO:0043549|GO:0006915|GO:1901224|GO:0033674|GO:0045859|GO:0045860|GO:0006468|GO:0042325|GO:0001932|GO:0007250|GO:0001934|GO:0042327|GO:0071902|GO:0071900|GO:0032147 macromolecular complex|structural molecule activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|protein complex scaffold|cellular metabolic process|regulation of signaling|cellular component organization|positive regulation of metabolic process|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell death|receptor signaling complex scaffold activity|positive regulation of cellular metabolic process|cellular component assembly|cytoplasm|CBM complex|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|positive regulation of signal transduction|protein metabolic process|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|macromolecule modification|positive regulation of transferase activity|protein modification process|positive regulation of protein metabolic process|protein complex assembly|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of intracellular signal transduction|regulation of programmed cell death|positive regulation of protein modification process|NIK/NF-kappaB signaling|phosphorylation|regulation of NIK/NF-kappaB signaling|regulation of apoptotic process|cellular protein modification process|regulation of kinase activity|apoptotic process|positive regulation of NIK/NF-kappaB signaling|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity - - - - 22:37490362-37519542 176 223 327 1270 1203 1044 1.36855044821558 1.57591500365949 2.29249814685265 8.84808066898694 7.67504647728698 7.60811165600056 1.74565453290924 8.04374626742483 -2.20409949770822 1.76110450304128e-21 1.63788205089702e-19 DOWN ENSG00000104723 TUSC3 tumor suppressor candidate 3 [Source:HGNC Symbol;Acc:HGNC:30242] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0022857|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0006810|GO:0050877|GO:0005887|GO:0043231|GO:0005737|GO:0005975|GO:0042592|GO:0019725|GO:0022891|GO:0031226|GO:0055085|GO:0005783|GO:0016757|GO:0008250|GO:0016021|GO:0044249|GO:0045454|GO:0019538|GO:0034645|GO:0043412|GO:0006487|GO:0009100|GO:0036211|GO:0006811|GO:0015075|GO:0016758|GO:1990234|GO:0070085|GO:0005739|GO:1901137|GO:0044267|GO:0050890|GO:0009059|GO:1903830|GO:0009101|GO:0043413|GO:0004576|GO:0006812|GO:0018279|GO:0006464|GO:0008324|GO:0004579|GO:0018193|GO:0022890|GO:0030001|GO:0043687|GO:0046873|GO:0015095|GO:0015693 macromolecular complex|transporter activity|cell|membrane|cellular process|metabolic process|catalytic activity|transmembrane transporter activity|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|plasma membrane|protein complex|endomembrane system|transferase activity|organelle membrane|protein glycosylation|transport|neurological system process|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|endoplasmic reticulum|transferase activity, transferring glycosyl groups|oligosaccharyltransferase complex|integral component of membrane|cellular biosynthetic process|cell redox homeostasis|protein metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|protein N-linked glycosylation|glycoprotein metabolic process|protein modification process|ion transport|ion transmembrane transporter activity|transferase activity, transferring hexosyl groups|transferase complex|glycosylation|mitochondrion|carbohydrate derivative biosynthetic process|cellular protein metabolic process|cognition|macromolecule biosynthetic process|magnesium ion transmembrane transport|glycoprotein biosynthetic process|macromolecule glycosylation|oligosaccharyl transferase activity|cation transport|protein N-linked glycosylation via asparagine|cellular protein modification process|cation transmembrane transporter activity|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|peptidyl-amino acid modification|inorganic cation transmembrane transporter activity|metal ion transport|post-translational protein modification|metal ion transmembrane transporter activity|magnesium ion transmembrane transporter activity|magnesium ion transport K12669 oligosaccharyltransferase complex subunit gamma[-] hsa01100|hsa04141|hsa00510 Metabolic pathways - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 8:15417215-15766649 327 307 424 1482 1695 1403 2.41223989881185 2.05821588934531 2.8200187521864 9.79531565032212 10.2591181613732 9.6997191099703 2.43015818011452 9.91805097388854 -2.0290064175395 1.75943334621958e-21 1.63788205089702e-19 DOWN ENSG00000118515 SGK1 serum/glucocorticoid regulated kinase 1 [Source:HGNC Symbol;Acc:HGNC:10810] GO:0040011|GO:0032502|GO:0040007|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0042175|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0048870|GO:0009653|GO:0016043|GO:0045927|GO:0043227|GO:0044708|GO:0048037|GO:0008289|GO:0071944|GO:0040008|GO:0009058|GO:0050793|GO:0016247|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0051726|GO:0042127|GO:0007049|GO:0003014|GO:0045595|GO:0006725|GO:0048468|GO:0009314|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0007275|GO:0050877|GO:0016358|GO:0034641|GO:0043168|GO:0030307|GO:0005543|GO:0001882|GO:0043270|GO:0016772|GO:0046483|GO:0051128|GO:0033554|GO:0007632|GO:0022607|GO:0003096|GO:0045597|GO:0043231|GO:0019899|GO:0005737|GO:0032886|GO:0005246|GO:0006928|GO:0042592|GO:0001696|GO:0043005|GO:0015459|GO:0019725|GO:0060548|GO:0006139|GO:0007154|GO:0055085|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0007586|GO:0008092|GO:0009725|GO:0008219|GO:0007611|GO:0017080|GO:0008217|GO:0050790|GO:0000166|GO:0030030|GO:0048869|GO:0017081|GO:2000145|GO:0044249|GO:0007017|GO:0019538|GO:0043254|GO:0010033|GO:0001558|GO:0031323|GO:0032411|GO:0003013|GO:0006996|GO:0051090|GO:0000902|GO:0005829|GO:0031175|GO:0031333|GO:0031344|GO:0044058|GO:0010468|GO:0034645|GO:0033993|GO:0035639|GO:0043412|GO:0007010|GO:0050773|GO:0007612|GO:0010720|GO:0070507|GO:0043069|GO:0048878|GO:0048813|GO:0035091|GO:0051252|GO:0001883|GO:0060453|GO:0031346|GO:0000904|GO:0030334|GO:0036211|GO:0007613|GO:0006811|GO:0032549|GO:0055082|GO:0048156|GO:0051046|GO:0070294|GO:0031981|GO:0050769|GO:0070293|GO:0048471|GO:0005654|GO:0022604|GO:0005739|GO:0006461|GO:0016301|GO:0043269|GO:0019900|GO:0012501|GO:0014070|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0010467|GO:0010765|GO:0032990|GO:0007399|GO:0046903|GO:0071310|GO:0050890|GO:0017076|GO:0010770|GO:0009059|GO:0030154|GO:0009755|GO:0048858|GO:1900006|GO:0016070|GO:0000226|GO:0016773|GO:0008015|GO:0032870|GO:0005634|GO:0009416|GO:0043067|GO:0048545|GO:0006974|GO:0051960|GO:0008542|GO:0034220|GO:0048666|GO:0030182|GO:0043401|GO:0043241|GO:0010975|GO:0034622|GO:0010769|GO:0031113|GO:0032774|GO:0005524|GO:0008306|GO:0006812|GO:2001141|GO:0043623|GO:0030554|GO:0016310|GO:0050775|GO:0071383|GO:0071407|GO:0031110|GO:0051494|GO:0051493|GO:0032272|GO:0048814|GO:0031109|GO:0042981|GO:0050801|GO:0043066|GO:0004672|GO:0007616|GO:0019901|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0071396|GO:0031960|GO:0046717|GO:0010976|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0045666|GO:0007019|GO:0051384|GO:0051258|GO:0006468|GO:0048699|GO:0043624|GO:0004712|GO:0031111|GO:1903506|GO:0043423|GO:0018193|GO:0004674|GO:0002028|GO:0030001|GO:0031115|GO:0071384|GO:0046785|GO:0043402|GO:0045664|GO:0030003|GO:0015672|GO:0071385|GO:0006814|GO:0055065|GO:0006875|GO:0018105|GO:0051261|GO:0006883|GO:0055078 locomotion|developmental process|growth|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cell motility|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|membrane-bounded organelle|single-organism behavior|cofactor binding|lipid binding|cell periphery|regulation of growth|biosynthetic process|regulation of developmental process|channel regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|renal system process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|response to radiation|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|neurological system process|dendrite development|cellular nitrogen compound metabolic process|anion binding|positive regulation of cell growth|phospholipid binding|nucleoside binding|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|visual behavior|cellular component assembly|renal sodium ion transport|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of microtubule-based process|calcium channel regulator activity|movement of cell or subcellular component|homeostatic process|gastric acid secretion|neuron projection|potassium channel regulator activity|cellular homeostasis|negative regulation of cell death|nucleobase-containing compound metabolic process|cell communication|transmembrane transport|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|digestion|cytoskeletal protein binding|response to hormone|cell death|learning or memory|sodium channel regulator activity|regulation of blood pressure|regulation of catalytic activity|nucleotide binding|cell projection organization|cellular developmental process|chloride channel regulator activity|regulation of cell motility|cellular biosynthetic process|microtubule-based process|protein metabolic process|regulation of protein complex assembly|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|positive regulation of transporter activity|circulatory system process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|cell morphogenesis|cytosol|neuron projection development|negative regulation of protein complex assembly|regulation of cell projection organization|regulation of digestive system process|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|regulation of dendrite development|learning|positive regulation of cell development|regulation of microtubule cytoskeleton organization|negative regulation of programmed cell death|chemical homeostasis|dendrite morphogenesis|phosphatidylinositol binding|regulation of RNA metabolic process|purine nucleoside binding|regulation of gastric acid secretion|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|regulation of cell migration|protein modification process|memory|ion transport|ribonucleoside binding|cellular chemical homeostasis|tau protein binding|regulation of secretion|renal sodium ion absorption|nuclear lumen|positive regulation of neurogenesis|renal absorption|perinuclear region of cytoplasm|nucleoplasm|regulation of cell morphogenesis|mitochondrion|protein complex assembly|kinase activity|regulation of ion transport|kinase binding|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|gene expression|positive regulation of sodium ion transport|cell part morphogenesis|nervous system development|secretion|cellular response to organic substance|cognition|purine nucleotide binding|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|cell projection morphogenesis|positive regulation of dendrite development|RNA metabolic process|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|blood circulation|cellular response to hormone stimulus|nucleus|response to light stimulus|regulation of programmed cell death|response to steroid hormone|cellular response to DNA damage stimulus|regulation of nervous system development|visual learning|ion transmembrane transport|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|protein complex disassembly|regulation of neuron projection development|cellular macromolecular complex assembly|regulation of cell morphogenesis involved in differentiation|regulation of microtubule polymerization|RNA biosynthetic process|ATP binding|associative learning|cation transport|regulation of RNA biosynthetic process|cellular protein complex assembly|adenyl nucleotide binding|phosphorylation|positive regulation of dendrite morphogenesis|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|regulation of microtubule polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|regulation of dendrite morphogenesis|microtubule polymerization or depolymerization|regulation of apoptotic process|ion homeostasis|negative regulation of apoptotic process|protein kinase activity|long-term memory|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|cellular response to lipid|response to corticosteroid|acid secretion|positive regulation of neuron projection development|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|positive regulation of neuron differentiation|microtubule depolymerization|response to glucocorticoid|protein polymerization|protein phosphorylation|generation of neurons|cellular protein complex disassembly|protein serine/threonine/tyrosine kinase activity|negative regulation of microtubule polymerization or depolymerization|regulation of nucleic acid-templated transcription|3-phosphoinositide-dependent protein kinase binding|peptidyl-amino acid modification|protein serine/threonine kinase activity|regulation of sodium ion transport|metal ion transport|negative regulation of microtubule polymerization|cellular response to corticosteroid stimulus|microtubule polymerization|glucocorticoid mediated signaling pathway|regulation of neuron differentiation|cellular cation homeostasis|monovalent inorganic cation transport|cellular response to glucocorticoid stimulus|sodium ion transport|metal ion homeostasis|cellular metal ion homeostasis|peptidyl-serine phosphorylation|protein depolymerization|cellular sodium ion homeostasis|sodium ion homeostasis K13302 serum/glucocorticoid-regulated kinase 1[2.7.11.1] hsa04151|hsa04068|hsa04960 PI3K-Akt signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Aldosterone-regulated sodium reabsorption - Homo sapiens (human) 6:134169246-134318112 320 304 355 66 72 53 0.857904124259814 0.740698875574649 0.858087591352152 0.158537352117756 0.158375994855276 0.133165344154689 0.818896863728872 0.150026230375907 2.44846700098839 1.78614054970785e-21 1.65600745251485e-19 UP ENSG00000102763 VWA8 von Willebrand factor A domain containing 8 [Source:HGNC Symbol;Acc:HGNC:29071] GO:0005623|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0016787|GO:0005622|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005737|GO:0000166|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0005739|GO:0017076|GO:0005524|GO:0030554|GO:0016462|GO:0017111|GO:0016887 cell|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|hydrolase activity|intracellular|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|mitochondrion|purine nucleotide binding|ATP binding|adenyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity - - - - 13:41566837-41961120 104 114 207 741 888 821 0.893987343705633 0.890600612105228 1.60428844906722 5.7070896689111 6.26295851479688 6.61410099403275 1.12962546829269 6.19471639258024 -2.45519371342028 2.099301472746e-21 1.94032650672938e-19 DOWN ENSG00000143632 ACTA1 actin, alpha 1, skeletal muscle [Source:HGNC Symbol;Acc:HGNC:129] GO:0032502|GO:0040007|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0005200|GO:0051716|GO:0042995|GO:0097159|GO:0043229|GO:0016049|GO:0071704|GO:0043167|GO:0009628|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0031252|GO:0005615|GO:0005622|GO:0072562|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0030017|GO:0009888|GO:0048468|GO:0009612|GO:0005884|GO:0009991|GO:0007275|GO:0048513|GO:0043168|GO:0001882|GO:0031982|GO:0022607|GO:0061061|GO:0005737|GO:0003012|GO:0006928|GO:0009887|GO:0048729|GO:0030027|GO:0070062|GO:0008092|GO:0009725|GO:0000166|GO:0048869|GO:0030029|GO:0010035|GO:0010033|GO:0043503|GO:0006996|GO:0005829|GO:0010468|GO:0006936|GO:0005865|GO:0033993|GO:0035639|GO:0007010|GO:0042692|GO:0017022|GO:0030048|GO:0090131|GO:0001883|GO:0010628|GO:0010038|GO:0032432|GO:0060537|GO:0032549|GO:0043531|GO:0043292|GO:0060485|GO:0030175|GO:0055001|GO:0030036|GO:0042641|GO:0070925|GO:0014070|GO:0010467|GO:0017076|GO:0030154|GO:0030239|GO:0007517|GO:0005856|GO:0048545|GO:0055002|GO:0014866|GO:0015629|GO:0060538|GO:0070252|GO:0030016|GO:0005524|GO:0010226|GO:0030554|GO:0001725|GO:0051146|GO:0030049|GO:0031032|GO:0014706|GO:0007015|GO:0030240|GO:0033275|GO:0007519|GO:0048747|GO:0014902|GO:0014904|GO:0048741 developmental process|growth|structural molecule activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|small molecule binding|extracellular vesicle|structural constituent of cytoskeleton|cellular response to stimulus|cell projection|organic cyclic compound binding|intracellular organelle|cell growth|organic substance metabolic process|ion binding|response to abiotic stimulus|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|cell leading edge|extracellular space|intracellular|blood microparticle|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|sarcomere|tissue development|cell development|response to mechanical stimulus|actin filament|response to extracellular stimulus|multicellular organism development|animal organ development|anion binding|nucleoside binding|vesicle|cellular component assembly|muscle structure development|cytoplasm|muscle system process|movement of cell or subcellular component|organ morphogenesis|tissue morphogenesis|lamellipodium|extracellular exosome|cytoskeletal protein binding|response to hormone|nucleotide binding|cellular developmental process|actin filament-based process|response to inorganic substance|response to organic substance|skeletal muscle fiber adaptation|organelle organization|cytosol|regulation of gene expression|muscle contraction|striated muscle thin filament|response to lipid|purine ribonucleoside triphosphate binding|cytoskeleton organization|muscle cell differentiation|myosin binding|actin filament-based movement|mesenchyme migration|purine nucleoside binding|positive regulation of gene expression|response to metal ion|actin filament bundle|muscle tissue development|ribonucleoside binding|ADP binding|contractile fiber|mesenchyme development|filopodium|muscle cell development|actin cytoskeleton organization|actomyosin|organelle assembly|response to organic cyclic compound|gene expression|purine nucleotide binding|cell differentiation|myofibril assembly|muscle organ development|cytoskeleton|response to steroid hormone|striated muscle cell development|skeletal myofibril assembly|actin cytoskeleton|skeletal muscle organ development|actin-mediated cell contraction|myofibril|ATP binding|response to lithium ion|adenyl nucleotide binding|stress fiber|striated muscle cell differentiation|muscle filament sliding|actomyosin structure organization|striated muscle tissue development|actin filament organization|skeletal muscle thin filament assembly|actin-myosin filament sliding|skeletal muscle tissue development|muscle fiber development|myotube differentiation|myotube cell development|skeletal muscle fiber development - - - - 1:229431245-229434098 100 99 58 0 5 2 3.29468448978155 2.9643564650609 1.72289719024483 0 0.135165298194642 0.0617473175386289 2.66064604836243 0.065637538577757 5.34111164950048 2.14026172755408e-21 1.97207943254319e-19 UP ENSG00000115970 THADA thyroid adenoma associated [Source:HGNC Symbol;Acc:HGNC:19217] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 2:43230836-43596046 127 147 191 787 915 649 0.460697086696656 0.484628914373389 0.624682439168229 2.55789907020306 2.72332796445404 2.2064040276882 0.523336146746091 2.49587702078177 -2.25373703588559 2.22356014827827e-21 2.04252814359075e-19 DOWN ENSG00000083642 PDS5B PDS5 cohesin associated factor B [Source:HGNC Symbol;Acc:HGNC:20418] GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0043167|GO:0000785|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0042127|GO:0007049|GO:0022402|GO:0003676|GO:0043168|GO:0001882|GO:0043231|GO:0005737|GO:0008285|GO:0007059|GO:0000166|GO:0051301|GO:0006996|GO:0051276|GO:0005829|GO:0003677|GO:0000819|GO:0035639|GO:1903047|GO:0001883|GO:0000278|GO:0032549|GO:0031981|GO:0007062|GO:0005654|GO:0005694|GO:0007067|GO:0017076|GO:0005634|GO:0005524|GO:0007064|GO:0030554|GO:0000070|GO:0000775 macromolecular complex|cell|cellular process|binding|small molecule binding|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|ion binding|chromatin|cellular component organization|membrane-bounded organelle|intracellular|protein binding|regulation of cell proliferation|cell cycle|cell cycle process|nucleic acid binding|anion binding|nucleoside binding|intracellular membrane-bounded organelle|cytoplasm|negative regulation of cell proliferation|chromosome segregation|nucleotide binding|cell division|organelle organization|chromosome organization|cytosol|DNA binding|sister chromatid segregation|purine ribonucleoside triphosphate binding|mitotic cell cycle process|purine nucleoside binding|mitotic cell cycle|ribonucleoside binding|nuclear lumen|sister chromatid cohesion|nucleoplasm|chromosome|mitotic nuclear division|purine nucleotide binding|nucleus|ATP binding|mitotic sister chromatid cohesion|adenyl nucleotide binding|mitotic sister chromatid segregation|chromosome, centromeric region - - - - 13:32586427-32778019 346 358 432 1524 1710 1453 1.48693433877256 1.3982292918777 1.67383865314029 5.8681135688944 6.02948260844951 5.85208486724748 1.51966742793018 5.91656034819713 -1.96100306311688 2.29596240604121e-21 2.1025663088943e-19 DOWN ENSG00000140443 IGF1R insulin like growth factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:5465] GO:0040011|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0033218|GO:0097159|GO:0004872|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0042562|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0038023|GO:0048870|GO:0023051|GO:0040017|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0019222|GO:0042802|GO:0008284|GO:0051272|GO:0042127|GO:0042277|GO:0017046|GO:0006725|GO:0019838|GO:1901360|GO:0010941|GO:0005102|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:2000147|GO:0033554|GO:0022607|GO:0005887|GO:0043231|GO:0010243|GO:0004888|GO:0043235|GO:0006928|GO:0032403|GO:0009966|GO:0060548|GO:0010646|GO:0006139|GO:0031226|GO:0007154|GO:0044092|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0043560|GO:0009725|GO:0008219|GO:0050790|GO:0000166|GO:0043548|GO:0043086|GO:0016021|GO:0043559|GO:2000145|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0000165|GO:0032268|GO:0034645|GO:0005520|GO:0007166|GO:0035639|GO:0043412|GO:0043069|GO:0001883|GO:1901652|GO:0071417|GO:0030334|GO:0036211|GO:0032269|GO:0032549|GO:0005158|GO:0031098|GO:0043434|GO:0006259|GO:0006461|GO:0016301|GO:0012501|GO:0051054|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:1902532|GO:0017076|GO:0031328|GO:0051246|GO:0009059|GO:0030335|GO:1902531|GO:0016773|GO:0032870|GO:0010557|GO:0043067|GO:0006260|GO:0051259|GO:1901653|GO:0043408|GO:0031994|GO:0005524|GO:0030554|GO:0016310|GO:0048017|GO:0007167|GO:0071375|GO:0006275|GO:0032872|GO:0042981|GO:0043066|GO:0004672|GO:0043409|GO:0033673|GO:0032868|GO:0045740|GO:0004714|GO:0006464|GO:0051403|GO:0043549|GO:0006915|GO:0045859|GO:0048015|GO:0051389|GO:0006469|GO:0046328|GO:0006468|GO:0005010|GO:0043405|GO:0042325|GO:0004713|GO:0007254|GO:0001932|GO:0032869|GO:0018193|GO:0042326|GO:0001933|GO:0051262|GO:0007169|GO:0048009|GO:0046777|GO:0014065|GO:0071900|GO:0008286|GO:0018108|GO:0038083 locomotion|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|amide binding|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|hormone binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|signaling receptor activity|cell motility|regulation of signaling|positive regulation of locomotion|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|transferase activity|regulation of metabolic process|identical protein binding|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|peptide binding|peptide hormone binding|cellular aromatic compound metabolic process|growth factor binding|organic cyclic compound metabolic process|regulation of cell death|receptor binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell motility|cellular response to stress|cellular component assembly|integral component of plasma membrane|intracellular membrane-bounded organelle|response to organonitrogen compound|transmembrane signaling receptor activity|receptor complex|movement of cell or subcellular component|protein complex binding|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|cell communication|negative regulation of molecular function|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|insulin receptor substrate binding|response to hormone|cell death|regulation of catalytic activity|nucleotide binding|phosphatidylinositol 3-kinase binding|negative regulation of catalytic activity|integral component of membrane|insulin binding|regulation of cell motility|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|cellular macromolecule biosynthetic process|insulin-like growth factor binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|negative regulation of programmed cell death|purine nucleoside binding|response to peptide|cellular response to organonitrogen compound|regulation of cell migration|protein modification process|negative regulation of cellular protein metabolic process|ribonucleoside binding|insulin receptor binding|stress-activated protein kinase signaling cascade|response to peptide hormone|DNA metabolic process|protein complex assembly|kinase activity|programmed cell death|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|purine nucleotide binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of cell migration|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|DNA replication|protein oligomerization|cellular response to peptide|regulation of MAPK cascade|insulin-like growth factor I binding|ATP binding|adenyl nucleotide binding|phosphorylation|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|regulation of DNA replication|regulation of stress-activated MAPK cascade|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|response to insulin|positive regulation of DNA replication|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|apoptotic process|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|inactivation of MAPKK activity|negative regulation of protein kinase activity|regulation of JNK cascade|protein phosphorylation|insulin-like growth factor-activated receptor activity|regulation of MAP kinase activity|regulation of phosphorylation|protein tyrosine kinase activity|JNK cascade|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|negative regulation of phosphorylation|negative regulation of protein phosphorylation|protein tetramerization|transmembrane receptor protein tyrosine kinase signaling pathway|insulin-like growth factor receptor signaling pathway|protein autophosphorylation|phosphatidylinositol 3-kinase signaling|regulation of protein serine/threonine kinase activity|insulin receptor signaling pathway|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation K05087 insulin-like growth factor 1 receptor[2.7.10.1] hsa05200|hsa04151|hsa04144|hsa04014|hsa04015|hsa05205|hsa04510|hsa05202|hsa04550|hsa04068|hsa04152|hsa04114|hsa04066|hsa04914|hsa04211|hsa05215|hsa04520|hsa05218|hsa05214|hsa04213|hsa04730|hsa04913 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|Melanoma - Homo sapiens (human)|Glioma - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|Ovarian steroidogenesis - Homo sapiens (human) 15:98648971-98964530 59 55 136 585 730 853 0.169541999769011 0.143639585595007 0.352356793406395 1.50619712666003 1.72115079264151 2.29724012833052 0.221846126256804 1.84152934921069 -3.05327312322472 2.34348433358864e-21 2.1395223637601e-19 DOWN ENSG00000157837 SPPL3 signal peptide peptidase like 3 [Source:HGNC Symbol;Acc:HGNC:30424] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0051050|GO:0042175|GO:0071704|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0071944|GO:0009893|GO:0016787|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005789|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0042802|GO:0060341|GO:0002757|GO:0098554|GO:0006810|GO:0030660|GO:0031982|GO:0031325|GO:0051098|GO:0043231|GO:0031227|GO:0008233|GO:0005737|GO:0032880|GO:0012506|GO:0051222|GO:0042592|GO:0098562|GO:0009966|GO:0046983|GO:0045184|GO:0019725|GO:0032388|GO:0010646|GO:0050776|GO:0030176|GO:1900182|GO:0008104|GO:0007154|GO:0007165|GO:0050778|GO:0005783|GO:0051649|GO:0090316|GO:0016021|GO:0009967|GO:0019538|GO:0031301|GO:0031323|GO:0005794|GO:1902533|GO:0032268|GO:0042307|GO:0005829|GO:0005798|GO:0007166|GO:0043412|GO:0005793|GO:0072594|GO:0031410|GO:0071556|GO:0048878|GO:0032386|GO:0051223|GO:0015031|GO:0033116|GO:0016023|GO:0036211|GO:0070201|GO:0046907|GO:0005791|GO:0055082|GO:0002429|GO:0071458|GO:0051099|GO:0051247|GO:0006508|GO:0031988|GO:0002764|GO:1904591|GO:0034613|GO:0032270|GO:0006796|GO:0035556|GO:0030659|GO:0044267|GO:0051174|GO:0017038|GO:0000139|GO:0051246|GO:1903827|GO:1902531|GO:0042803|GO:0006606|GO:0043393|GO:0050850|GO:1904589|GO:0016311|GO:0033365|GO:0033157|GO:0031401|GO:0051169|GO:0006605|GO:0002768|GO:0033619|GO:0016482|GO:0006886|GO:0070001|GO:0004175|GO:0032092|GO:0042993|GO:0050801|GO:0042306|GO:1900180|GO:0006464|GO:0050851|GO:0019932|GO:0050848|GO:0042991|GO:0006873|GO:0046824|GO:0006470|GO:0035304|GO:1903533|GO:0006913|GO:0035307|GO:0051533|GO:0051531|GO:0004190|GO:0070886|GO:0070884|GO:0019722|GO:0048016|GO:0042990|GO:0035306|GO:0050852|GO:0030003|GO:0035303|GO:0034504|GO:0046822|GO:0051170|GO:0042500|GO:0055065|GO:0033173|GO:0006875|GO:0006874|GO:0055074|GO:0051480|GO:0007204 immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|positive regulation of transport|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|immune response|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|hydrolase activity|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|endoplasmic reticulum membrane|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|identical protein binding|regulation of cellular localization|immune response-activating signal transduction|cytoplasmic side of endoplasmic reticulum membrane|transport|Golgi-associated vesicle membrane|vesicle|positive regulation of cellular metabolic process|regulation of binding|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|peptidase activity|cytoplasm|regulation of protein localization|vesicle membrane|positive regulation of protein transport|homeostatic process|cytoplasmic side of membrane|regulation of signal transduction|protein dimerization activity|establishment of protein localization|cellular homeostasis|positive regulation of intracellular transport|regulation of cell communication|regulation of immune response|integral component of endoplasmic reticulum membrane|positive regulation of protein localization to nucleus|protein localization|cell communication|signal transduction|positive regulation of immune response|endoplasmic reticulum|establishment of localization in cell|positive regulation of intracellular protein transport|integral component of membrane|positive regulation of signal transduction|protein metabolic process|integral component of organelle membrane|regulation of cellular metabolic process|Golgi apparatus|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|positive regulation of protein import into nucleus|cytosol|Golgi-associated vesicle|cell surface receptor signaling pathway|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|establishment of protein localization to organelle|cytoplasmic vesicle|integral component of lumenal side of endoplasmic reticulum membrane|chemical homeostasis|regulation of intracellular transport|regulation of protein transport|protein transport|endoplasmic reticulum-Golgi intermediate compartment membrane|cytoplasmic, membrane-bounded vesicle|protein modification process|regulation of establishment of protein localization|intracellular transport|rough endoplasmic reticulum|cellular chemical homeostasis|immune response-activating cell surface receptor signaling pathway|integral component of cytoplasmic side of endoplasmic reticulum membrane|positive regulation of binding|positive regulation of protein metabolic process|proteolysis|membrane-bounded vesicle|immune response-regulating signaling pathway|positive regulation of protein import|cellular protein localization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic vesicle membrane|cellular protein metabolic process|regulation of phosphorus metabolic process|protein import|Golgi membrane|regulation of protein metabolic process|regulation of cellular protein localization|regulation of intracellular signal transduction|protein homodimerization activity|protein import into nucleus|regulation of protein binding|positive regulation of calcium-mediated signaling|regulation of protein import|dephosphorylation|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|nuclear transport|protein targeting|immune response-regulating cell surface receptor signaling pathway|membrane protein proteolysis|cytosolic transport|intracellular protein transport|aspartic-type peptidase activity|endopeptidase activity|positive regulation of protein binding|positive regulation of transcription factor import into nucleus|ion homeostasis|regulation of protein import into nucleus|regulation of protein localization to nucleus|cellular protein modification process|antigen receptor-mediated signaling pathway|second-messenger-mediated signaling|regulation of calcium-mediated signaling|transcription factor import into nucleus|cellular ion homeostasis|positive regulation of nucleocytoplasmic transport|protein dephosphorylation|regulation of protein dephosphorylation|regulation of protein targeting|nucleocytoplasmic transport|positive regulation of protein dephosphorylation|positive regulation of NFAT protein import into nucleus|NFAT protein import into nucleus|aspartic-type endopeptidase activity|positive regulation of calcineurin-NFAT signaling cascade|regulation of calcineurin-NFAT signaling cascade|calcium-mediated signaling|inositol phosphate-mediated signaling|regulation of transcription factor import into nucleus|positive regulation of dephosphorylation|T cell receptor signaling pathway|cellular cation homeostasis|regulation of dephosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import|aspartic endopeptidase activity, intramembrane cleaving|metal ion homeostasis|calcineurin-NFAT signaling cascade|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration - - - - 12:120762510-120904371 92 108 154 581 660 619 0.790551396498503 0.843419415031524 1.19309438946537 4.47315659128232 4.65320282084872 4.98493976088275 0.942355066998466 4.7037663910046 -2.31947375569015 2.39756674736703e-21 2.18222431938705e-19 DOWN ENSG00000156504 FAM122B family with sequence similarity 122B [Source:HGNC Symbol;Acc:HGNC:30490] GO:0032991|GO:0043234|GO:0005581 macromolecular complex|protein complex|collagen trimer - - - - X:134769566-134797232 368 349 595 1864 2373 2056 2.09590530289895 1.80646528584969 3.05531184274681 9.51191094444389 11.0889356616513 10.9742856736663 2.31922747716515 10.5250440932538 -2.18211004115228 2.42152855920458e-21 2.19733476007579e-19 DOWN ENSG00000249378 LINC01060 long intergenic non-protein coding RNA 1060 [Source:HGNC Symbol;Acc:HGNC:49081] - - - - - - 4:188400736-188681051 2 4 0 69 74 59 0.0407334079747567 0.0740423865005119 0 1.25917608244788 1.23663085461452 1.12621727455749 0.0382585981584229 1.2073414038733 -4.979905866597 2.44013190722948e-21 2.20750599874027e-19 DOWN ENSG00000183826 BTBD9 BTB (POZ) domain containing 9 [Source:HGNC Symbol;Acc:HGNC:21228] GO:0007610|GO:0048511|GO:0009987|GO:0008152|GO:0005488|GO:0007622|GO:0050794|GO:0006807|GO:0007623|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0044708|GO:0005515|GO:0007626|GO:0060341|GO:0008344|GO:0006725|GO:0051640|GO:0030534|GO:0006810|GO:1901360|GO:0060627|GO:0050877|GO:0034641|GO:0046483|GO:0051128|GO:0030431|GO:0042592|GO:0051656|GO:0048871|GO:0051649|GO:0007611|GO:0048512|GO:0016192|GO:0051650|GO:0060586|GO:0048878|GO:0042428|GO:0032386|GO:0048489|GO:0007613|GO:0046907|GO:1902803|GO:0007600|GO:0030100|GO:0018958|GO:0042748|GO:0050890|GO:0051648|GO:0042745|GO:0022410|GO:0050951|GO:0048259|GO:0016482|GO:0036465|GO:1903421|GO:0050801|GO:0007616|GO:0006897|GO:1900242|GO:0048488|GO:0006898|GO:2000369|GO:0072583|GO:0055065|GO:0055072 behavior|rhythmic process|cellular process|metabolic process|binding|rhythmic behavior|regulation of cellular process|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|single-organism behavior|protein binding|locomotory behavior|regulation of cellular localization|adult locomotory behavior|cellular aromatic compound metabolic process|organelle localization|adult behavior|transport|organic cyclic compound metabolic process|regulation of vesicle-mediated transport|neurological system process|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|sleep|homeostatic process|establishment of organelle localization|multicellular organismal homeostasis|establishment of localization in cell|learning or memory|circadian behavior|vesicle-mediated transport|establishment of vesicle localization|multicellular organismal iron ion homeostasis|chemical homeostasis|serotonin metabolic process|regulation of intracellular transport|synaptic vesicle transport|memory|intracellular transport|regulation of synaptic vesicle transport|sensory perception|regulation of endocytosis|phenol-containing compound metabolic process|circadian sleep/wake cycle, non-REM sleep|cognition|vesicle localization|circadian sleep/wake cycle|circadian sleep/wake cycle process|sensory perception of temperature stimulus|regulation of receptor-mediated endocytosis|cytosolic transport|synaptic vesicle recycling|regulation of synaptic vesicle recycling|ion homeostasis|long-term memory|endocytosis|regulation of synaptic vesicle endocytosis|synaptic vesicle endocytosis|receptor-mediated endocytosis|regulation of clathrin-mediated endocytosis|clathrin-mediated endocytosis|metal ion homeostasis|iron ion homeostasis - - - - 6:38168451-38640148 17 11 40 257 280 328 0.104976316070996 0.0617364249260266 0.222702342340882 1.42194099652153 1.41865308078549 1.89825182340962 0.129805027779302 1.57961530023888 -3.60515507710403 2.4741203805774e-21 2.23149214023437e-19 DOWN ENSG00000275052 PPP4R3B protein phosphatase 4 regulatory subunit 3B [Source:HGNC Symbol;Acc:HGNC:29267] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0008287|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0044262|GO:0044281|GO:0031325|GO:0030289|GO:0043231|GO:0005737|GO:0005975|GO:0006629|GO:0044249|GO:0019538|GO:0031323|GO:0006109|GO:0005813|GO:0043412|GO:0005815|GO:0036211|GO:0031981|GO:0005996|GO:0005654|GO:0006796|GO:0044267|GO:0019216|GO:0031328|GO:0005856|GO:0005634|GO:0016051|GO:0019318|GO:0016311|GO:0045722|GO:0006111|GO:0010906|GO:0015630|GO:0006464|GO:0010907|GO:0006470|GO:0019319|GO:0006006|GO:0006094 macromolecular complex|cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|protein serine/threonine phosphatase complex|intracellular|protein binding|protein complex|regulation of metabolic process|cellular carbohydrate metabolic process|small molecule metabolic process|positive regulation of cellular metabolic process|protein phosphatase 4 complex|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|lipid metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of carbohydrate metabolic process|centrosome|macromolecule modification|microtubule organizing center|protein modification process|nuclear lumen|monosaccharide metabolic process|nucleoplasm|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of lipid metabolic process|positive regulation of cellular biosynthetic process|cytoskeleton|nucleus|carbohydrate biosynthetic process|hexose metabolic process|dephosphorylation|positive regulation of gluconeogenesis|regulation of gluconeogenesis|regulation of glucose metabolic process|microtubule cytoskeleton|cellular protein modification process|positive regulation of glucose metabolic process|protein dephosphorylation|hexose biosynthetic process|glucose metabolic process|gluconeogenesis K17491 protein phosphatase 4 regulatory subunit 3[-] hsa04922 Glucagon signaling pathway - Homo sapiens (human) 2:55547292-55618880 464 459 686 2225 2448 2225 2.42711655769971 2.18205295266958 3.23527389985446 10.4279834536279 10.5063568071708 10.9076631938755 2.61481447007458 10.6140011515581 -2.02118811925991 2.5290593645733e-21 2.27417283945697e-19 DOWN ENSG00000144036 EXOC6B exocyst complex component 6B [Source:HGNC Symbol;Acc:HGNC:17085] GO:0032991|GO:0005623|GO:0009987|GO:0071944|GO:0005622|GO:0043234|GO:0006810|GO:0000145|GO:0005938|GO:0032940|GO:0005737|GO:0022406|GO:0045184|GO:0008104|GO:0016192|GO:0048278|GO:0015031|GO:0006887|GO:0046903|GO:0006904 macromolecular complex|cell|cellular process|cell periphery|intracellular|protein complex|transport|exocyst|cell cortex|secretion by cell|cytoplasm|membrane docking|establishment of protein localization|protein localization|vesicle-mediated transport|vesicle docking|protein transport|exocytosis|secretion|vesicle docking involved in exocytosis - - - - 2:72175984-72826041 111 82 215 901 1006 1190 0.646983348917704 0.434373662696415 1.12985448775114 4.70535535541288 4.81100710979083 6.50048692687383 0.73707049978842 5.33894979735918 -2.85668146042421 2.59993589574586e-21 2.33088547242033e-19 DOWN ENSG00000151726 ACSL1 acyl-CoA synthetase long-chain family member 1 [Source:HGNC Symbol;Acc:HGNC:3569] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0019867|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0016874|GO:0005622|GO:0005789|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0044255|GO:0006810|GO:0006082|GO:0009991|GO:0009410|GO:0043168|GO:0044281|GO:0001882|GO:0031325|GO:0043231|GO:0005737|GO:0031966|GO:0051186|GO:0042493|GO:0043085|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0009725|GO:0006805|GO:0050790|GO:0000166|GO:0016021|GO:0044249|GO:0010876|GO:0019538|GO:0010033|GO:0031323|GO:0006790|GO:0007584|GO:0032268|GO:0005740|GO:0046486|GO:0007166|GO:0033993|GO:0035639|GO:0043412|GO:0034097|GO:0006637|GO:0005741|GO:0006631|GO:0001883|GO:0051347|GO:0036211|GO:0006811|GO:0032549|GO:0006638|GO:0071466|GO:0006869|GO:0051247|GO:0005739|GO:0070542|GO:0032270|GO:0014070|GO:0006796|GO:0044267|GO:0051174|GO:0008610|GO:0071310|GO:0017076|GO:0051246|GO:0009755|GO:0031667|GO:0032870|GO:0042178|GO:0015645|GO:0005778|GO:0033559|GO:0006820|GO:0034201|GO:0015711|GO:0019221|GO:0031401|GO:0005777|GO:0005524|GO:0001676|GO:0033211|GO:0030554|GO:0016310|GO:0015908|GO:0009108|GO:0046942|GO:0071345|GO:0019752|GO:0006639|GO:0006464|GO:0043549|GO:0033674|GO:0004467|GO:0015718|GO:0036109|GO:0045859|GO:0045860|GO:0006468|GO:0042325|GO:0043651|GO:0001932|GO:0046949|GO:0032787|GO:0001934|GO:0035336|GO:0042327|GO:0006641|GO:0015909|GO:0019432|GO:0071902|GO:0035338|GO:0071900|GO:0044539 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|outer membrane|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|ligase activity|intracellular|endoplasmic reticulum membrane|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|cellular lipid metabolic process|transport|organic acid metabolic process|response to extracellular stimulus|response to xenobiotic stimulus|anion binding|small molecule metabolic process|nucleoside binding|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|cofactor metabolic process|response to drug|positive regulation of catalytic activity|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|response to hormone|xenobiotic metabolic process|regulation of catalytic activity|nucleotide binding|integral component of membrane|cellular biosynthetic process|lipid localization|protein metabolic process|response to organic substance|regulation of cellular metabolic process|sulfur compound metabolic process|response to nutrient|regulation of cellular protein metabolic process|mitochondrial envelope|glycerolipid metabolic process|cell surface receptor signaling pathway|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|response to cytokine|acyl-CoA metabolic process|mitochondrial outer membrane|fatty acid metabolic process|purine nucleoside binding|positive regulation of transferase activity|protein modification process|ion transport|ribonucleoside binding|neutral lipid metabolic process|cellular response to xenobiotic stimulus|lipid transport|positive regulation of protein metabolic process|mitochondrion|response to fatty acid|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|lipid biosynthetic process|cellular response to organic substance|purine nucleotide binding|regulation of protein metabolic process|hormone-mediated signaling pathway|response to nutrient levels|cellular response to hormone stimulus|xenobiotic catabolic process|fatty acid ligase activity|peroxisomal membrane|unsaturated fatty acid metabolic process|anion transport|response to oleic acid|organic anion transport|cytokine-mediated signaling pathway|positive regulation of protein modification process|peroxisome|ATP binding|long-chain fatty acid metabolic process|adiponectin-activated signaling pathway|adenyl nucleotide binding|phosphorylation|fatty acid transport|coenzyme biosynthetic process|carboxylic acid transport|cellular response to cytokine stimulus|carboxylic acid metabolic process|acylglycerol metabolic process|cellular protein modification process|regulation of kinase activity|positive regulation of kinase activity|long-chain fatty acid-CoA ligase activity|monocarboxylic acid transport|alpha-linolenic acid metabolic process|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|linoleic acid metabolic process|regulation of protein phosphorylation|fatty-acyl-CoA biosynthetic process|monocarboxylic acid metabolic process|positive regulation of protein phosphorylation|long-chain fatty-acyl-CoA metabolic process|positive regulation of phosphorylation|triglyceride metabolic process|long-chain fatty acid transport|triglyceride biosynthetic process|positive regulation of protein serine/threonine kinase activity|long-chain fatty-acyl-CoA biosynthetic process|regulation of protein serine/threonine kinase activity|long-chain fatty acid import K01897 long-chain acyl-CoA synthetase[6.2.1.3] hsa01100|hsa04146|hsa04920|hsa03320|hsa01212|hsa00071|hsa00061 Metabolic pathways - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Fatty acid metabolism - Homo sapiens (human)|Fatty acid degradation - Homo sapiens (human)|Fatty acid biosynthesis - Homo sapiens (human) 4:184755595-184826818 285 327 444 1418 1564 1812 1.4660771015916 1.52875995960393 2.05924811683875 6.5355999884027 6.601099131172 8.73571821751227 1.68469505934476 7.29080577902899 -2.11359079191178 2.76978854334667e-21 2.47572656206801e-19 DOWN ENSG00000130347 RTN4IP1 reticulon 4 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:18647] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0043231|GO:0043169|GO:0005737|GO:0055114|GO:0046872|GO:0005739|GO:0046914|GO:0008270 cell|metabolic process|binding|catalytic activity|oxidoreductase activity|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidation-reduction process|metal ion binding|mitochondrion|transition metal ion binding|zinc ion binding - - - - 6:106571971-106629487 6 9 16 126 150 109 0.157302215600071 0.214461135422348 0.378224177890073 2.95987062847035 3.22672581540853 2.67830354482079 0.249995842970831 2.95496666289989 -3.56316584391716 2.80785560868016e-21 2.50226033855336e-19 DOWN ENSG00000198586 TLK1 tousled like kinase 1 [Source:HGNC Symbol;Acc:HGNC:11841] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0007049|GO:0006810|GO:0043168|GO:0001882|GO:0016772|GO:0051128|GO:0033554|GO:0043231|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0000166|GO:0019538|GO:0006996|GO:0051276|GO:0035639|GO:0043412|GO:0006325|GO:0001883|GO:0015031|GO:0036211|GO:0046907|GO:0032549|GO:0016301|GO:0034613|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0017076|GO:0016773|GO:0005634|GO:0006974|GO:0005524|GO:0030554|GO:0016310|GO:0033044|GO:0006886|GO:0006333|GO:0004672|GO:0016568|GO:0006464|GO:0006468|GO:0004674|GO:0001672 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|transferase activity|cell cycle|transport|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|establishment of protein localization|protein localization|cell communication|signal transduction|establishment of localization in cell|nucleotide binding|protein metabolic process|organelle organization|chromosome organization|purine ribonucleoside triphosphate binding|macromolecule modification|chromatin organization|purine nucleoside binding|protein transport|protein modification process|intracellular transport|ribonucleoside binding|kinase activity|cellular protein localization|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|cellular response to DNA damage stimulus|ATP binding|adenyl nucleotide binding|phosphorylation|regulation of chromosome organization|intracellular protein transport|chromatin assembly or disassembly|protein kinase activity|chromatin modification|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity|regulation of chromatin assembly or disassembly - - - - 2:170990823-171231314 274 323 309 1275 1398 1106 1.41411964840813 1.51501743734111 1.43783142086177 5.89580198815864 5.91984130961024 5.34957479075287 1.45565616887034 5.72173936284058 -1.97478415527998 3.10057231230987e-21 2.75489541106246e-19 DOWN ENSG00000141252 VPS53 VPS53 GARP complex subunit [Source:HGNC Symbol;Acc:HGNC:25608] GO:0032991|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006810|GO:0031982|GO:1990745|GO:0043231|GO:0005737|GO:0000938|GO:0045184|GO:0008104|GO:0051649|GO:0010008|GO:0005794|GO:0005768|GO:0016192|GO:0031410|GO:0015031|GO:0016023|GO:0046907|GO:0055037|GO:0048471|GO:0031988|GO:0032456|GO:0042147|GO:0016482|GO:0016197 macromolecular complex|cell|membrane|binding|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|transport|vesicle|EARP complex|intracellular membrane-bounded organelle|cytoplasm|GARP complex|establishment of protein localization|protein localization|establishment of localization in cell|endosome membrane|Golgi apparatus|endosome|vesicle-mediated transport|cytoplasmic vesicle|protein transport|cytoplasmic, membrane-bounded vesicle|intracellular transport|recycling endosome|perinuclear region of cytoplasm|membrane-bounded vesicle|endocytic recycling|retrograde transport, endosome to Golgi|cytosolic transport|endosomal transport - - - - 17:508668-721717 57 68 161 737 833 775 0.160438452127558 0.173949963844524 0.408580349060236 1.85866529286706 1.92375166183194 2.04440212056894 0.247656255010773 1.94227302508931 -2.97133505004161 3.45137419124234e-21 3.05748739185011e-19 DOWN ENSG00000182185 RAD51B RAD51 paralog B [Source:HGNC Symbol;Acc:HGNC:9822] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0000150|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0031224|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0007131|GO:0050817|GO:0006281|GO:0001824|GO:0006725|GO:0009888|GO:0009314|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0043168|GO:0016788|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0022607|GO:0043231|GO:0009611|GO:0045787|GO:0006139|GO:0007126|GO:0001832|GO:0000166|GO:0016021|GO:0050878|GO:0000707|GO:0006996|GO:0003677|GO:0090068|GO:0000725|GO:0035639|GO:1903047|GO:0007596|GO:0001883|GO:0044770|GO:0009790|GO:0006302|GO:0016818|GO:0000278|GO:0042060|GO:0005657|GO:0032549|GO:0007127|GO:0031981|GO:0004518|GO:0007346|GO:0007599|GO:0010564|GO:0005654|GO:0006259|GO:0005694|GO:0060429|GO:0033063|GO:0010212|GO:0017076|GO:0045931|GO:0005634|GO:0006974|GO:0000724|GO:0042148|GO:0009792|GO:0004536|GO:0034622|GO:0043566|GO:0000086|GO:0003697|GO:0005524|GO:0044772|GO:0030554|GO:0003690|GO:1901990|GO:0061053|GO:1901989|GO:1901992|GO:0065004|GO:0006310|GO:0004519|GO:1901987|GO:0016462|GO:0004520|GO:0010389|GO:0000730|GO:0045003|GO:0017111|GO:0006312|GO:1902751|GO:0043009|GO:0010971|GO:1902749|GO:0016887|GO:0001701|GO:0000400|GO:0042623|GO:0008094 developmental process|growth|macromolecular complex|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|recombinase activity|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|reciprocal meiotic recombination|coagulation|DNA repair|blastocyst development|cellular aromatic compound metabolic process|tissue development|response to radiation|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|response to wounding|positive regulation of cell cycle|nucleobase-containing compound metabolic process|meiotic nuclear division|blastocyst growth|nucleotide binding|integral component of membrane|regulation of body fluid levels|meiotic DNA recombinase assembly|organelle organization|DNA binding|positive regulation of cell cycle process|recombinational repair|purine ribonucleoside triphosphate binding|mitotic cell cycle process|blood coagulation|purine nucleoside binding|cell cycle phase transition|embryo development|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|wound healing|replication fork|ribonucleoside binding|meiosis I|nuclear lumen|nuclease activity|regulation of mitotic cell cycle|hemostasis|regulation of cell cycle process|nucleoplasm|DNA metabolic process|chromosome|epithelium development|Rad51B-Rad51C-Rad51D-XRCC2 complex|response to ionizing radiation|purine nucleotide binding|positive regulation of mitotic cell cycle|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|strand invasion|embryo development ending in birth or egg hatching|deoxyribonuclease activity|cellular macromolecular complex assembly|structure-specific DNA binding|G2/M transition of mitotic cell cycle|single-stranded DNA binding|ATP binding|mitotic cell cycle phase transition|adenyl nucleotide binding|double-stranded DNA binding|regulation of mitotic cell cycle phase transition|somite development|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|protein-DNA complex assembly|DNA recombination|endonuclease activity|regulation of cell cycle phase transition|pyrophosphatase activity|endodeoxyribonuclease activity|regulation of G2/M transition of mitotic cell cycle|DNA recombinase assembly|double-strand break repair via synthesis-dependent strand annealing|nucleoside-triphosphatase activity|mitotic recombination|positive regulation of cell cycle G2/M phase transition|chordate embryonic development|positive regulation of G2/M transition of mitotic cell cycle|regulation of cell cycle G2/M phase transition|ATPase activity|in utero embryonic development|four-way junction DNA binding|ATPase activity, coupled|DNA-dependent ATPase activity K10869 RAD51-like protein 1[-] hsa03440 Homologous recombination - Homo sapiens (human) 14:67819779-68730218 15 14 22 151 152 168 0.0911621767073567 0.0773281406570129 0.120547331864762 0.822248998493495 0.757949530354152 0.956904850800299 0.0963458830763772 0.845701126549315 -3.13385297479653 3.63017970830112e-21 3.20637233762194e-19 DOWN ENSG00000197555 SIPA1L1 signal-induced proliferation-associated 1 like 1 [Source:HGNC Symbol;Acc:HGNC:20284] GO:0032502|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0060076|GO:0043229|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009893|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0019222|GO:0050804|GO:0045595|GO:0048468|GO:0007275|GO:0005102|GO:0016358|GO:0008047|GO:0051128|GO:0045211|GO:0050803|GO:0005737|GO:0007267|GO:0043005|GO:0009966|GO:0043197|GO:0036477|GO:0014069|GO:0010646|GO:0043085|GO:0007154|GO:0060996|GO:0007165|GO:0050790|GO:0030030|GO:0048869|GO:0030029|GO:0006996|GO:0000902|GO:0060998|GO:0031175|GO:0031344|GO:0005096|GO:0048167|GO:0007166|GO:0060997|GO:0007010|GO:0044309|GO:0050773|GO:0051345|GO:0097061|GO:0048813|GO:0030695|GO:0000904|GO:0030425|GO:0022604|GO:0046875|GO:0030036|GO:0035556|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:1902531|GO:0005856|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0031532|GO:0010769|GO:0043087|GO:0061564|GO:0043547|GO:0007167|GO:0048814|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0050767|GO:0048812|GO:0061001|GO:0090630|GO:0007409|GO:0048699|GO:0050770|GO:0045664|GO:0007268|GO:0007169|GO:0048013 developmental process|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|excitatory synapse|intracellular organelle|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|synaptic membrane|regulation of metabolic process|modulation of synaptic transmission|regulation of cell differentiation|cell development|multicellular organism development|receptor binding|dendrite development|enzyme activator activity|regulation of cellular component organization|postsynaptic membrane|regulation of synapse structure or activity|cytoplasm|cell-cell signaling|neuron projection|regulation of signal transduction|dendritic spine|somatodendritic compartment|postsynaptic density|regulation of cell communication|positive regulation of catalytic activity|cell communication|dendritic spine development|signal transduction|regulation of catalytic activity|cell projection organization|cellular developmental process|actin filament-based process|organelle organization|cell morphogenesis|regulation of dendritic spine development|neuron projection development|regulation of cell projection organization|GTPase activator activity|regulation of synaptic plasticity|cell surface receptor signaling pathway|dendritic spine morphogenesis|cytoskeleton organization|neuron spine|regulation of dendrite development|positive regulation of hydrolase activity|dendritic spine organization|dendrite morphogenesis|GTPase regulator activity|cell morphogenesis involved in differentiation|dendrite|regulation of cell morphogenesis|ephrin receptor binding|actin cytoskeleton organization|intracellular signal transduction|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cytoskeleton|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|actin cytoskeleton reorganization|regulation of cell morphogenesis involved in differentiation|regulation of GTPase activity|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of dendrite morphogenesis|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|regulation of neurogenesis|neuron projection morphogenesis|regulation of dendritic spine morphogenesis|activation of GTPase activity|axonogenesis|generation of neurons|regulation of axonogenesis|regulation of neuron differentiation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|ephrin receptor signaling pathway K17701 signal-induced proliferation-associated 1 like protein 1[-] hsa04015 Rap1 signaling pathway - Homo sapiens (human) 14:71320449-71741229 195 213 273 1032 984 930 0.837147190259557 0.831050905352896 1.05668351828631 3.96958547496777 3.46601763009377 3.74179159093415 0.908293871299588 3.72579823199856 -2.03631849752494 3.77374710155283e-21 3.32334648878343e-19 DOWN ENSG00000226121 AC009487.6 - - - - - - - 2:161500885-161507705 204 220 278 1004 1119 902 2.11557095014142 2.07347990872237 2.59930086741097 9.32887554849209 9.52129265162066 8.76663496646303 2.26278390875825 9.20560105552526 -2.02441310487811 3.84185248841389e-21 3.37337247615025e-19 DOWN ENSG00000152422 XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 [Source:HGNC Symbol;Acc:HGNC:12831] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0016032|GO:0006281|GO:0006725|GO:0008022|GO:0009314|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0070419|GO:0032807|GO:0043231|GO:0005737|GO:0006139|GO:0043085|GO:0050790|GO:0010035|GO:0019538|GO:1990391|GO:0019043|GO:0005829|GO:0003677|GO:0005813|GO:0043412|GO:0005815|GO:0010038|GO:0006302|GO:0036211|GO:0051103|GO:0031981|GO:0051351|GO:0005654|GO:0006259|GO:0010212|GO:0071241|GO:0044267|GO:0005958|GO:0005856|GO:0005634|GO:0006974|GO:0006303|GO:0075713|GO:0010226|GO:0015630|GO:0006266|GO:0006310|GO:0010165|GO:0006464|GO:0071248|GO:0071285|GO:0018193|GO:0043687|GO:0032446|GO:0018205|GO:0016925 macromolecular complex|cell|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|protein complex|regulation of metabolic process|viral process|DNA repair|cellular aromatic compound metabolic process|protein C-terminus binding|response to radiation|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|nonhomologous end joining complex|DNA ligase IV complex|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of catalytic activity|response to inorganic substance|protein metabolic process|DNA repair complex|establishment of viral latency|cytosol|DNA binding|centrosome|macromolecule modification|microtubule organizing center|response to metal ion|double-strand break repair|protein modification process|DNA ligation involved in DNA repair|nuclear lumen|positive regulation of ligase activity|nucleoplasm|DNA metabolic process|response to ionizing radiation|cellular response to inorganic substance|cellular protein metabolic process|DNA-dependent protein kinase-DNA ligase 4 complex|cytoskeleton|nucleus|cellular response to DNA damage stimulus|double-strand break repair via nonhomologous end joining|establishment of integrated proviral latency|response to lithium ion|microtubule cytoskeleton|DNA ligation|DNA recombination|response to X-ray|cellular protein modification process|cellular response to metal ion|cellular response to lithium ion|peptidyl-amino acid modification|post-translational protein modification|protein modification by small protein conjugation|peptidyl-lysine modification|protein sumoylation K10886 DNA-repair protein XRCC4[-] hsa03450 Non-homologous end-joining - Homo sapiens (human) 5:83077498-83353787 19 34 43 270 281 232 0.26703175571023 0.43428735757766 0.544875047353085 3.4000105583026 3.24036047446495 3.05587062982147 0.415398053546992 3.23208055419634 -2.95989679409892 3.88280181231364e-21 3.39933036084491e-19 DOWN ENSG00000137266 SLC22A23 solute carrier family 22 member 23 [Source:HGNC Symbol;Acc:HGNC:21106] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0022857|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0006811|GO:0015075|GO:0006820|GO:0015711|GO:0008509|GO:0008514 transporter activity|cell|membrane|cellular process|binding|transmembrane transporter activity|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|ion transport|ion transmembrane transporter activity|anion transport|organic anion transport|anion transmembrane transporter activity|organic anion transmembrane transporter activity - - - - 6:3268962-3457022 73 66 121 561 561 874 0.279788795434395 0.2298960737548 0.418124765516052 1.92649935660552 1.7641637033149 3.13941291100005 0.309269878235082 2.27669199030682 -2.88000089286187 3.92009864101871e-21 3.4219480944144e-19 DOWN ENSG00000154803 FLCN folliculin [Source:HGNC Symbol;Acc:HGNC:27310] GO:0040011|GO:0032502|GO:0040007|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0030496|GO:0051716|GO:0040013|GO:0042995|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0048870|GO:0023051|GO:0045926|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:1903828|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0005085|GO:0048856|GO:0005929|GO:0019222|GO:0060341|GO:0051726|GO:0042127|GO:0007049|GO:1903706|GO:1900181|GO:0010506|GO:0045595|GO:0006725|GO:0001822|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0016570|GO:0048513|GO:0051302|GO:0044291|GO:2000505|GO:0034641|GO:0044281|GO:0030155|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0090287|GO:0022607|GO:0010942|GO:0043231|GO:2000506|GO:0072111|GO:0030308|GO:0005737|GO:0010508|GO:0032880|GO:0071559|GO:0006928|GO:0032403|GO:0042592|GO:0009966|GO:0072372|GO:0009890|GO:0048871|GO:0010646|GO:0006139|GO:0043085|GO:0055086|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0045785|GO:0008219|GO:0051271|GO:0008285|GO:0050790|GO:0051301|GO:0048869|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0006996|GO:0000165|GO:0051276|GO:1902533|GO:0032268|GO:0010468|GO:0034645|GO:0045216|GO:0007166|GO:0043412|GO:0030097|GO:0051345|GO:0001655|GO:0010629|GO:0019693|GO:0007005|GO:0031056|GO:0051252|GO:0006325|GO:0005773|GO:0009790|GO:0016573|GO:0010628|GO:0030334|GO:0036211|GO:0032269|GO:0071560|GO:0009116|GO:0072001|GO:0034329|GO:0032465|GO:0010564|GO:0051247|GO:0070848|GO:0030511|GO:0030336|GO:0034613|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:1901137|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0097009|GO:0071310|GO:1902532|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:1901723|GO:0043068|GO:1903827|GO:1902531|GO:0016070|GO:0000910|GO:0010557|GO:0005634|GO:0043067|GO:1901532|GO:0051896|GO:0043491|GO:0009142|GO:0032006|GO:0045893|GO:0033365|GO:0009792|GO:0051898|GO:0031401|GO:0009124|GO:0043065|GO:0031929|GO:0009259|GO:0043408|GO:0000323|GO:0045892|GO:0009117|GO:0032774|GO:0046390|GO:0045980|GO:0032008|GO:2001141|GO:0071363|GO:0043087|GO:0016310|GO:0033044|GO:1902679|GO:0070371|GO:0010823|GO:0007179|GO:0043547|GO:0007167|GO:2000973|GO:0010821|GO:0006163|GO:0042981|GO:0035065|GO:0043409|GO:0016568|GO:0002244|GO:0051056|GO:1900180|GO:0007264|GO:0006464|GO:0051058|GO:0009165|GO:0007043|GO:0042278|GO:0017015|GO:0006351|GO:0006915|GO:0006355|GO:0032007|GO:0045944|GO:0006366|GO:0007265|GO:0046578|GO:0006164|GO:1903507|GO:1903578|GO:0006357|GO:0005764|GO:0006468|GO:0002320|GO:1903506|GO:0042325|GO:0001932|GO:0018193|GO:1903579|GO:0042326|GO:0043009|GO:0001934|GO:0007178|GO:0001933|GO:0000122|GO:0070372|GO:0070373|GO:0042327|GO:0009156|GO:0034504|GO:0046580|GO:0046034|GO:0035024|GO:0002328|GO:0009152|GO:0009168|GO:0035023|GO:0001701|GO:0007266|GO:0006473|GO:0018205|GO:2001170|GO:0018394|GO:0006475|GO:0006754|GO:0018393 locomotion|developmental process|growth|immune system process|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|midbody|cellular response to stimulus|negative regulation of locomotion|cell projection|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|cell motility|regulation of signaling|negative regulation of growth|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|negative regulation of cellular protein localization|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|anatomical structure development|cilium|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of hemopoiesis|negative regulation of protein localization to nucleus|regulation of autophagy|regulation of cell differentiation|cellular aromatic compound metabolic process|kidney development|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|histone modification|animal organ development|regulation of cell division|cell-cell contact zone|regulation of energy homeostasis|cellular nitrogen compound metabolic process|small molecule metabolic process|regulation of cell adhesion|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|regulation of cellular response to growth factor stimulus|cellular component assembly|positive regulation of cell death|intracellular membrane-bounded organelle|negative regulation of energy homeostasis|cell proliferation involved in kidney development|negative regulation of cell growth|cytoplasm|positive regulation of autophagy|regulation of protein localization|response to transforming growth factor beta|movement of cell or subcellular component|protein complex binding|homeostatic process|regulation of signal transduction|primary cilium|negative regulation of biosynthetic process|multicellular organismal homeostasis|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|positive regulation of cell adhesion|cell death|negative regulation of cellular component movement|negative regulation of cell proliferation|regulation of catalytic activity|cell division|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|organelle organization|MAPK cascade|chromosome organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|cell-cell junction organization|cell surface receptor signaling pathway|macromolecule modification|hemopoiesis|positive regulation of hydrolase activity|urogenital system development|negative regulation of gene expression|ribose phosphate metabolic process|mitochondrion organization|regulation of histone modification|regulation of RNA metabolic process|chromatin organization|vacuole|embryo development|histone acetylation|positive regulation of gene expression|regulation of cell migration|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|nucleoside metabolic process|renal system development|cell junction assembly|regulation of cytokinesis|regulation of cell cycle process|positive regulation of protein metabolic process|response to growth factor|positive regulation of transforming growth factor beta receptor signaling pathway|negative regulation of cell migration|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|energy homeostasis|cellular response to organic substance|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|negative regulation of cell proliferation involved in kidney development|positive regulation of programmed cell death|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|cytokinesis|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|regulation of hematopoietic progenitor cell differentiation|regulation of protein kinase B signaling|protein kinase B signaling|nucleoside triphosphate biosynthetic process|regulation of TOR signaling|positive regulation of transcription, DNA-templated|protein localization to organelle|embryo development ending in birth or egg hatching|negative regulation of protein kinase B signaling|positive regulation of protein modification process|nucleoside monophosphate biosynthetic process|positive regulation of apoptotic process|TOR signaling|ribonucleotide metabolic process|regulation of MAPK cascade|lytic vacuole|negative regulation of transcription, DNA-templated|nucleotide metabolic process|RNA biosynthetic process|ribose phosphate biosynthetic process|negative regulation of nucleotide metabolic process|positive regulation of TOR signaling|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|regulation of chromosome organization|negative regulation of RNA biosynthetic process|ERK1 and ERK2 cascade|negative regulation of mitochondrion organization|transforming growth factor beta receptor signaling pathway|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of pro-B cell differentiation|regulation of mitochondrion organization|purine nucleotide metabolic process|regulation of apoptotic process|regulation of histone acetylation|negative regulation of MAPK cascade|chromatin modification|hematopoietic progenitor cell differentiation|regulation of small GTPase mediated signal transduction|regulation of protein localization to nucleus|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|nucleotide biosynthetic process|cell-cell junction assembly|purine nucleoside metabolic process|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|negative regulation of TOR signaling|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of Ras protein signal transduction|purine nucleotide biosynthetic process|negative regulation of nucleic acid-templated transcription|regulation of ATP metabolic process|regulation of transcription from RNA polymerase II promoter|lysosome|protein phosphorylation|lymphoid progenitor cell differentiation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of ATP metabolic process|negative regulation of phosphorylation|chordate embryonic development|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|ribonucleoside monophosphate biosynthetic process|protein localization to nucleus|negative regulation of Ras protein signal transduction|ATP metabolic process|negative regulation of Rho protein signal transduction|pro-B cell differentiation|purine ribonucleotide biosynthetic process|purine ribonucleoside monophosphate biosynthetic process|regulation of Rho protein signal transduction|in utero embryonic development|Rho protein signal transduction|protein acetylation|peptidyl-lysine modification|negative regulation of ATP biosynthetic process|peptidyl-lysine acetylation|internal protein amino acid acetylation|ATP biosynthetic process|internal peptidyl-lysine acetylation K09594 folliculin[-] hsa05211 Renal cell carcinoma - Homo sapiens (human) 17:17212212-17237188 1451 1530 1562 457 423 457 8.30952102951608 7.96305811849156 8.06498656355819 2.34488793790777 1.98754591828653 2.45275206785451 8.11252190385528 2.2617286413496 1.84272462097656 4.53695418532141e-21 3.94886968654768e-19 UP ENSG00000164506 STXBP5 syntaxin binding protein 5 (tomosyn) [Source:HGNC Symbol;Acc:HGNC:19665] GO:0032991|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0008021|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0071704|GO:0051641|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0031224|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:0031201|GO:0050817|GO:0006810|GO:0098797|GO:0060627|GO:0008047|GO:0032940|GO:0031982|GO:0030141|GO:0005887|GO:0043231|GO:0030133|GO:0019899|GO:0005737|GO:0009611|GO:0032880|GO:0012506|GO:0043235|GO:0045184|GO:0000149|GO:0031226|GO:0043085|GO:0008104|GO:1902495|GO:0051047|GO:0050790|GO:0016021|GO:0050878|GO:0016192|GO:0010468|GO:0030193|GO:0005096|GO:0031410|GO:0051345|GO:0007596|GO:0030695|GO:0051223|GO:0015031|GO:0045921|GO:0016023|GO:0006887|GO:0070201|GO:0070382|GO:0042060|GO:0017157|GO:0051046|GO:0007599|GO:0009306|GO:0031988|GO:0034702|GO:0030659|GO:0010467|GO:0046903|GO:0051020|GO:0005892|GO:0019905|GO:0050708|GO:0043087|GO:0043547|GO:0031267|GO:0017075|GO:0061041|GO:0017016|GO:0017137 macromolecular complex|synapse|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|synaptic vesicle|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|organic substance metabolic process|cellular localization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|enzyme regulator activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|SNARE complex|coagulation|transport|plasma membrane protein complex|regulation of vesicle-mediated transport|enzyme activator activity|secretion by cell|vesicle|secretory granule|integral component of plasma membrane|intracellular membrane-bounded organelle|transport vesicle|enzyme binding|cytoplasm|response to wounding|regulation of protein localization|vesicle membrane|receptor complex|establishment of protein localization|SNARE binding|intrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|transmembrane transporter complex|positive regulation of secretion|regulation of catalytic activity|integral component of membrane|regulation of body fluid levels|vesicle-mediated transport|regulation of gene expression|regulation of blood coagulation|GTPase activator activity|cytoplasmic vesicle|positive regulation of hydrolase activity|blood coagulation|GTPase regulator activity|regulation of protein transport|protein transport|positive regulation of exocytosis|cytoplasmic, membrane-bounded vesicle|exocytosis|regulation of establishment of protein localization|exocytic vesicle|wound healing|regulation of exocytosis|regulation of secretion|hemostasis|protein secretion|membrane-bounded vesicle|ion channel complex|cytoplasmic vesicle membrane|gene expression|secretion|GTPase binding|acetylcholine-gated channel complex|syntaxin binding|regulation of protein secretion|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase binding|syntaxin-1 binding|regulation of wound healing|Ras GTPase binding|Rab GTPase binding - - - - 6:147204425-147390476 25 46 72 359 465 388 0.140052147392688 0.234197821781674 0.363656153247477 1.80193147433398 2.13730708457569 2.03707238275704 0.245968707473946 1.99210364722224 -3.01774602096575 4.55539295996797e-21 3.95339248333965e-19 DOWN ENSG00000041353 RAB27B RAB27B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9767] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0043167|GO:0051641|GO:0045177|GO:0043473|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0060341|GO:0051640|GO:0006810|GO:0016324|GO:0060627|GO:0043168|GO:0032940|GO:0001882|GO:0031982|GO:0016817|GO:0030141|GO:0043231|GO:0030133|GO:0005737|GO:0012506|GO:0051656|GO:0045184|GO:0033059|GO:0019904|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0051649|GO:0008092|GO:0030667|GO:0010008|GO:0051047|GO:0000166|GO:0005794|GO:0005768|GO:0016192|GO:0051650|GO:0005798|GO:0035639|GO:0031410|GO:0017022|GO:0001883|GO:0051904|GO:0051875|GO:0015031|GO:0071985|GO:0045921|GO:0016023|GO:0006887|GO:0016818|GO:0046907|GO:0042588|GO:0032549|GO:0017157|GO:0051046|GO:0005770|GO:0031988|GO:0034613|GO:0035556|GO:0030659|GO:0005795|GO:0030140|GO:0046903|GO:0017076|GO:0051648|GO:0005771|GO:0019003|GO:0031902|GO:0042589|GO:0032561|GO:0032585|GO:0032400|GO:0051169|GO:0032402|GO:0006886|GO:0030135|GO:0005525|GO:0007264|GO:0031489|GO:0019001|GO:0016462|GO:0030136|GO:0032401|GO:0006913|GO:0017111|GO:0042470|GO:0003924 signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|ion binding|cellular localization|apical part of cell|pigmentation|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of cellular localization|organelle localization|transport|apical plasma membrane|regulation of vesicle-mediated transport|anion binding|secretion by cell|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|secretory granule|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|vesicle membrane|establishment of organelle localization|establishment of protein localization|cellular pigmentation|protein domain specific binding|protein localization|cell communication|signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|secretory granule membrane|endosome membrane|positive regulation of secretion|nucleotide binding|Golgi apparatus|endosome|vesicle-mediated transport|establishment of vesicle localization|Golgi-associated vesicle|purine ribonucleoside triphosphate binding|cytoplasmic vesicle|myosin binding|purine nucleoside binding|pigment granule transport|pigment granule localization|protein transport|multivesicular body sorting pathway|positive regulation of exocytosis|cytoplasmic, membrane-bounded vesicle|exocytosis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|zymogen granule|ribonucleoside binding|regulation of exocytosis|regulation of secretion|late endosome|membrane-bounded vesicle|cellular protein localization|intracellular signal transduction|cytoplasmic vesicle membrane|Golgi stack|trans-Golgi network transport vesicle|secretion|purine nucleotide binding|vesicle localization|multivesicular body|GDP binding|late endosome membrane|zymogen granule membrane|guanyl ribonucleotide binding|multivesicular body membrane|melanosome localization|nuclear transport|melanosome transport|intracellular protein transport|coated vesicle|GTP binding|small GTPase mediated signal transduction|myosin V binding|guanyl nucleotide binding|pyrophosphatase activity|clathrin-coated vesicle|establishment of melanosome localization|nucleocytoplasmic transport|nucleoside-triphosphatase activity|melanosome|GTPase activity K07886 Ras-related protein Rab-27B[-] hsa04972 Pancreatic secretion - Homo sapiens (human) 18:54717860-54895516 238 265 507 1642 2038 2232 2.0802400979921 2.10504948419761 3.99538341874608 12.8589933867243 14.6153180713206 18.2834955626371 2.72689100031193 15.2526023402273 -2.48372647184393 5.115249639608e-21 4.42639602147412e-19 DOWN ENSG00000179241 LDLRAD3 low density lipoprotein receptor class A domain containing 3 [Source:HGNC Symbol;Acc:HGNC:27046] GO:0005623|GO:0016020|GO:0008152|GO:0030054|GO:0005488|GO:0033218|GO:0071704|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0019222|GO:0042277|GO:0006810|GO:0016021|GO:0019538|GO:0016192|GO:0010468|GO:0051604|GO:0006508|GO:0010467|GO:0051246|GO:0001540|GO:0016485|GO:0030162|GO:0006897|GO:0070613|GO:0006898 cell|membrane|metabolic process|cell junction|binding|amide binding|organic substance metabolic process|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|regulation of metabolic process|peptide binding|transport|integral component of membrane|protein metabolic process|vesicle-mediated transport|regulation of gene expression|protein maturation|proteolysis|gene expression|regulation of protein metabolic process|beta-amyloid binding|protein processing|regulation of proteolysis|endocytosis|regulation of protein processing|receptor-mediated endocytosis - - - - 11:35943981-36232136 60 49 133 686 678 626 0.668695849966377 0.496314514972786 1.33641835454936 6.85013237268183 6.19976317446076 6.53853707987731 0.833809573162841 6.52947754233997 -2.9691777175381 5.5846741469607e-21 4.81863762957702e-19 DOWN ENSG00000180229 HERC2P3 hect domain and RLD 2 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:4871] - - - - - - 15:20379495-20506180 232 321 397 1257 1352 1476 1.27811384231784 1.60718492149838 1.97190440290769 6.20460053122985 6.11118371866171 7.62071885452351 1.6190677222413 6.64550103480502 -2.03721464315783 6.27854022070908e-21 5.40049874844856e-19 DOWN ENSG00000257365 FNTB farnesyltransferase, CAAX box, beta [Source:HGNC Symbol;Acc:HGNC:3785] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0033218|GO:0048523|GO:0051606|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0008144|GO:0009628|GO:0044237|GO:0023051|GO:0008289|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0019840|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0042277|GO:0009314|GO:0009582|GO:0043169|GO:0048144|GO:0005737|GO:0009611|GO:0009966|GO:0045787|GO:0010646|GO:0005875|GO:0007154|GO:0007165|GO:0016765|GO:0008285|GO:0010035|GO:0019538|GO:0010033|GO:0005829|GO:0007186|GO:0005965|GO:0046872|GO:0043412|GO:0009583|GO:0004659|GO:0034097|GO:0008277|GO:0036211|GO:0042060|GO:0007602|GO:0048145|GO:0022400|GO:1990234|GO:0071478|GO:0048146|GO:0018342|GO:0014070|GO:0044267|GO:0009059|GO:0005856|GO:0010557|GO:0009416|GO:0004311|GO:0008318|GO:0016056|GO:0015630|GO:0009584|GO:0051770|GO:0071482|GO:0018343|GO:0046914|GO:0007603|GO:0006464|GO:0004660|GO:0008270 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|amide binding|negative regulation of cellular process|detection of stimulus|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|drug binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|lipid binding|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|isoprenoid binding|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|peptide binding|response to radiation|detection of abiotic stimulus|cation binding|fibroblast proliferation|cytoplasm|response to wounding|regulation of signal transduction|positive regulation of cell cycle|regulation of cell communication|microtubule associated complex|cell communication|signal transduction|transferase activity, transferring alkyl or aryl (other than methyl) groups|negative regulation of cell proliferation|response to inorganic substance|protein metabolic process|response to organic substance|cytosol|G-protein coupled receptor signaling pathway|protein farnesyltransferase complex|metal ion binding|macromolecule modification|detection of light stimulus|prenyltransferase activity|response to cytokine|regulation of G-protein coupled receptor protein signaling pathway|protein modification process|wound healing|phototransduction|regulation of fibroblast proliferation|regulation of rhodopsin mediated signaling pathway|transferase complex|cellular response to radiation|positive regulation of fibroblast proliferation|protein prenylation|response to organic cyclic compound|cellular protein metabolic process|macromolecule biosynthetic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|response to light stimulus|farnesyltranstransferase activity|protein prenyltransferase activity|rhodopsin mediated signaling pathway|microtubule cytoskeleton|detection of visible light|positive regulation of nitric-oxide synthase biosynthetic process|cellular response to light stimulus|protein farnesylation|transition metal ion binding|phototransduction, visible light|cellular protein modification process|protein farnesyltransferase activity|zinc ion binding K05954 protein farnesyltransferase subunit beta[2.5.1.58] hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human) 14:64986720-65062652 52 43 52 287 349 349 0.565638021859338 0.42509371275686 0.509978772178282 2.79712372368863 3.11476983309227 3.55783735561896 0.50023683559816 3.15657697079995 -2.65767772929139 6.29521526247772e-21 5.40049874844856e-19 DOWN ENSG00000197712 FAM114A1 family with sequence similarity 114 member A1 [Source:HGNC Symbol;Acc:HGNC:25087] GO:0005623|GO:0005488|GO:0005622|GO:0005515|GO:0005737 cell|binding|intracellular|protein binding|cytoplasm - - - - 4:38867677-38945739 71 56 213 1483 1584 3029 0.829312232932771 0.594466465724553 2.24312383740991 15.5202494327014 15.1803922741567 33.1579867479775 1.22230084535574 21.2862094849452 -4.12224774151598 6.71845033673772e-21 5.74706637114521e-19 DOWN ENSG00000215421 ZNF407 zinc finger protein 407 [Source:HGNC Symbol;Acc:HGNC:19904] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0008270 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 18:74597870-75065671 32 37 35 240 327 225 0.0882910732599687 0.0927787113496935 0.0870660131721704 0.593294784302362 0.740248081359063 0.581800322265677 0.0893785992606109 0.638447729309034 -2.83656716897723 6.75714472869748e-21 5.76365139230098e-19 DOWN ENSG00000169914 OTUD3 OTU deubiquitinase 3 [Source:HGNC Symbol;Acc:HGNC:29038] GO:0009987|GO:0008152|GO:0003824|GO:0071704|GO:0044237|GO:0016787|GO:0008233|GO:0019538|GO:0036459|GO:0043412|GO:0036211|GO:0006508|GO:0044267|GO:0070646|GO:0004843|GO:0008234|GO:0006464|GO:0016579|GO:0044313|GO:0035871 cellular process|metabolic process|catalytic activity|organic substance metabolic process|cellular metabolic process|hydrolase activity|peptidase activity|protein metabolic process|thiol-dependent ubiquitinyl hydrolase activity|macromolecule modification|protein modification process|proteolysis|cellular protein metabolic process|protein modification by small protein removal|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|protein deubiquitination|protein K6-linked deubiquitination|protein K11-linked deubiquitination - - - - 1:19882513-19912945 948 1122 1343 331 318 366 9.55521971209157 10.27792456987 12.2045722088538 2.98921699250837 2.62982954502995 3.45734041443604 10.6792388302718 3.02546231732479 1.81958130078647 7.04844859651811e-21 5.99499670656557e-19 UP ENSG00000182324 KCNJ14 potassium channel, inwardly rectifying subfamily J, member 14 [Source:HGNC Symbol;Acc:HGNC:6260] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0042995|GO:0004872|GO:0022857|GO:0050794|GO:0044297|GO:0071944|GO:0031224|GO:0005886|GO:0043234|GO:0043025|GO:0006810|GO:0098797|GO:0005887|GO:0007267|GO:0043005|GO:0036477|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0071804|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0008076|GO:0030425|GO:0034765|GO:0034702|GO:0043269|GO:0071805|GO:0034220|GO:0015276|GO:0098655|GO:0005216|GO:0010107|GO:0034703|GO:0006812|GO:0008324|GO:0005244|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0005242|GO:0007268|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|cell projection|receptor activity|transmembrane transporter activity|regulation of cellular process|cell body|cell periphery|intrinsic component of membrane|plasma membrane|protein complex|neuronal cell body|transport|plasma membrane protein complex|integral component of plasma membrane|cell-cell signaling|neuron projection|somatodendritic compartment|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|cellular potassium ion transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|voltage-gated potassium channel complex|dendrite|regulation of ion transmembrane transport|ion channel complex|regulation of ion transport|potassium ion transmembrane transport|ion transmembrane transport|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|potassium ion import|cation channel complex|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|inward rectifier potassium channel activity|synaptic transmission|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity K05007 potassium inwardly-rectifying channel subfamily J member 14[-] hsa04921|hsa04725 Oxytocin signaling pathway - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human) 19:48455509-48466980 189 246 225 29 44 21 1.9236363850673 2.27549299445339 2.06470425659208 0.264462254171537 0.367435641450615 0.200308156321278 2.08794454537092 0.277402017314477 2.91203321091522 8.07761983597223e-21 6.85083132338395e-19 UP ENSG00000143970 ASXL2 additional sex combs like 2, transcriptional regulator [Source:HGNC Symbol;Acc:HGNC:23805] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0019222|GO:0045595|GO:0006725|GO:1901360|GO:0003676|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0045597|GO:0043231|GO:0043169|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0048869|GO:0009967|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0042975|GO:0010628|GO:0035358|GO:0035360|GO:0031981|GO:0045600|GO:0005654|GO:0010467|GO:0045598|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0010557|GO:0005634|GO:0030522|GO:0045893|GO:0045444|GO:0032774|GO:0035357|GO:2001141|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|peroxisome proliferator activated receptor binding|positive regulation of gene expression|regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of peroxisome proliferator activated receptor signaling pathway|nuclear lumen|positive regulation of fat cell differentiation|nucleoplasm|gene expression|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|intracellular receptor signaling pathway|positive regulation of transcription, DNA-templated|fat cell differentiation|RNA biosynthetic process|peroxisome proliferator activated receptor signaling pathway|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 2:25733753-25878516 282 322 395 1236 1360 1291 0.902370053590297 0.936420486268903 1.13958637606719 3.5436580555213 3.57061116458176 3.87160118649666 0.992792305308797 3.66195680219991 -1.88305093373284 8.63677547236537e-21 7.30431430458911e-19 DOWN ENSG00000154229 PRKCA protein kinase C, alpha [Source:HGNC Symbol;Acc:HGNC:9393] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0051606|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044089|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0048514|GO:0060341|GO:0008284|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:1903706|GO:0050817|GO:0016337|GO:2000707|GO:0045087|GO:0045595|GO:0006725|GO:0009314|GO:0006810|GO:0022402|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0010632|GO:0016570|GO:0048513|GO:0031664|GO:0034641|GO:0043168|GO:0015980|GO:0043062|GO:0044281|GO:0032940|GO:0006952|GO:0030155|GO:0001882|GO:0016772|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:2000147|GO:0022607|GO:0098609|GO:0009582|GO:0045597|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0007267|GO:0009611|GO:0032880|GO:0006928|GO:0001775|GO:0009966|GO:0050673|GO:0031966|GO:0045184|GO:0009890|GO:0046883|GO:0045787|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0009617|GO:0001525|GO:0055086|GO:0008104|GO:0050865|GO:0007154|GO:0044092|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0070062|GO:0045785|GO:0008219|GO:0010634|GO:0031666|GO:0050790|GO:0000166|GO:0006091|GO:0043086|GO:0010817|GO:0048869|GO:2000145|GO:0061110|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0043487|GO:0010033|GO:0031324|GO:0031323|GO:0010256|GO:0050878|GO:0006996|GO:0055114|GO:0071774|GO:0000165|GO:0050679|GO:0051276|GO:1902533|GO:0032268|GO:0005740|GO:0005829|GO:0006998|GO:0007186|GO:0010468|GO:0090132|GO:0030193|GO:0045216|GO:0030168|GO:0010613|GO:0046872|GO:0007166|GO:0090276|GO:0033993|GO:0035639|GO:0051350|GO:0051349|GO:1903047|GO:0001944|GO:0043412|GO:0009583|GO:0030097|GO:0072358|GO:0034097|GO:0051345|GO:0002237|GO:0019693|GO:0008277|GO:0016572|GO:0043069|GO:0007596|GO:0006325|GO:0001883|GO:0034109|GO:0051223|GO:0015031|GO:0090257|GO:0030334|GO:0031279|GO:0001935|GO:0001667|GO:0036211|GO:0000278|GO:0070201|GO:0042060|GO:0071219|GO:0042886|GO:0032549|GO:0007602|GO:0034329|GO:0045766|GO:0022407|GO:0051046|GO:0031981|GO:0045765|GO:0007346|GO:0022400|GO:0007599|GO:0044344|GO:0071478|GO:0009914|GO:0009306|GO:0051247|GO:0048471|GO:0070848|GO:0005654|GO:0005739|GO:0050678|GO:0016301|GO:0010543|GO:0006112|GO:0032270|GO:0012501|GO:0006796|GO:1901342|GO:0035556|GO:1901137|GO:0044267|GO:0051174|GO:0010611|GO:0014896|GO:0010467|GO:0045639|GO:0046903|GO:0071310|GO:0017076|GO:0010594|GO:0030198|GO:0006997|GO:0031281|GO:0031328|GO:0051246|GO:0030154|GO:0030335|GO:1902531|GO:0045931|GO:0072359|GO:0016773|GO:0032496|GO:0005634|GO:0009416|GO:0043067|GO:0010595|GO:0045637|GO:0097190|GO:0043488|GO:0050796|GO:0002521|GO:0002790|GO:0002761|GO:0043536|GO:0030073|GO:0007077|GO:0031401|GO:0070555|GO:0008543|GO:0070527|GO:0009259|GO:0043408|GO:0009117|GO:0005524|GO:0046390|GO:0016056|GO:0045980|GO:0050708|GO:0071363|GO:0090330|GO:0030554|GO:0043535|GO:0016310|GO:0015833|GO:0010608|GO:0038179|GO:0070371|GO:0007194|GO:0001936|GO:0007167|GO:0045761|GO:0051081|GO:0009584|GO:0002763|GO:0043410|GO:0071482|GO:0006163|GO:0010631|GO:0042981|GO:0045762|GO:0046914|GO:0043066|GO:0001938|GO:0004672|GO:0016568|GO:0007603|GO:0030099|GO:0006464|GO:0009165|GO:0071396|GO:0007043|GO:0046879|GO:0002934|GO:0060193|GO:0006915|GO:0071222|GO:0061041|GO:0031663|GO:0048011|GO:0003300|GO:0030072|GO:0002573|GO:0006164|GO:0030801|GO:0035173|GO:0010517|GO:0006468|GO:0034351|GO:0042325|GO:0070374|GO:0001932|GO:0007190|GO:0018193|GO:0004674|GO:0035408|GO:0009187|GO:0002159|GO:0001934|GO:0010518|GO:0034349|GO:0070372|GO:0043542|GO:0045651|GO:0008270|GO:0042327|GO:0030802|GO:0007268|GO:0007169|GO:0009190|GO:0048010|GO:0030818|GO:0010863|GO:0046058|GO:0030225|GO:0030819|GO:0009152|GO:0030817|GO:0052652|GO:0018105|GO:0030814|GO:0018107|GO:0030816|GO:0030815|GO:0004697|GO:0038127|GO:0043534|GO:0035403|GO:0006171|GO:0007173|GO:0007202 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|detection of stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of hemopoiesis|coagulation|single organismal cell-cell adhesion|positive regulation of dense core granule biogenesis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|response to radiation|transport|cell cycle process|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|histone modification|animal organ development|regulation of lipopolysaccharide-mediated signaling pathway|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|extracellular structure organization|small molecule metabolic process|secretion by cell|defense response|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell motility|cellular component assembly|cell-cell adhesion|detection of abiotic stimulus|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|muscle system process|cell-cell signaling|response to wounding|regulation of protein localization|movement of cell or subcellular component|cell activation|regulation of signal transduction|epithelial cell proliferation|mitochondrial membrane|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|positive regulation of cell cycle|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|angiogenesis|nucleobase-containing small molecule metabolic process|protein localization|regulation of cell activation|cell communication|negative regulation of molecular function|membrane organization|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|extracellular exosome|positive regulation of cell adhesion|cell death|positive regulation of epithelial cell migration|positive regulation of lipopolysaccharide-mediated signaling pathway|regulation of catalytic activity|nucleotide binding|generation of precursor metabolites and energy|negative regulation of catalytic activity|regulation of hormone levels|cellular developmental process|regulation of cell motility|dense core granule biogenesis|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|regulation of RNA stability|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endomembrane system organization|regulation of body fluid levels|organelle organization|oxidation-reduction process|response to fibroblast growth factor|MAPK cascade|positive regulation of epithelial cell proliferation|chromosome organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|mitochondrial envelope|cytosol|nuclear envelope organization|G-protein coupled receptor signaling pathway|regulation of gene expression|epithelium migration|regulation of blood coagulation|cell-cell junction organization|platelet activation|positive regulation of cardiac muscle hypertrophy|metal ion binding|cell surface receptor signaling pathway|regulation of peptide hormone secretion|response to lipid|purine ribonucleoside triphosphate binding|negative regulation of lyase activity|positive regulation of lyase activity|mitotic cell cycle process|vasculature development|macromolecule modification|detection of light stimulus|hemopoiesis|cardiovascular system development|response to cytokine|positive regulation of hydrolase activity|response to molecule of bacterial origin|ribose phosphate metabolic process|regulation of G-protein coupled receptor protein signaling pathway|histone phosphorylation|negative regulation of programmed cell death|blood coagulation|chromatin organization|purine nucleoside binding|homotypic cell-cell adhesion|regulation of protein transport|protein transport|regulation of muscle system process|regulation of cell migration|regulation of cyclase activity|endothelial cell proliferation|ameboidal-type cell migration|protein modification process|mitotic cell cycle|regulation of establishment of protein localization|wound healing|cellular response to molecule of bacterial origin|amide transport|ribonucleoside binding|phototransduction|cell junction assembly|positive regulation of angiogenesis|regulation of cell-cell adhesion|regulation of secretion|nuclear lumen|regulation of angiogenesis|regulation of mitotic cell cycle|regulation of rhodopsin mediated signaling pathway|hemostasis|cellular response to fibroblast growth factor stimulus|cellular response to radiation|hormone transport|protein secretion|positive regulation of protein metabolic process|perinuclear region of cytoplasm|response to growth factor|nucleoplasm|mitochondrion|regulation of epithelial cell proliferation|kinase activity|regulation of platelet activation|energy reserve metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of cardiac muscle hypertrophy|muscle hypertrophy|gene expression|positive regulation of myeloid cell differentiation|secretion|cellular response to organic substance|purine nucleotide binding|regulation of endothelial cell migration|extracellular matrix organization|nucleus organization|positive regulation of cyclase activity|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cell differentiation|positive regulation of cell migration|regulation of intracellular signal transduction|positive regulation of mitotic cell cycle|circulatory system development|phosphotransferase activity, alcohol group as acceptor|response to lipopolysaccharide|nucleus|response to light stimulus|regulation of programmed cell death|positive regulation of endothelial cell migration|regulation of myeloid cell differentiation|apoptotic signaling pathway|regulation of mRNA stability|regulation of insulin secretion|leukocyte differentiation|peptide secretion|regulation of myeloid leukocyte differentiation|positive regulation of blood vessel endothelial cell migration|insulin secretion|mitotic nuclear envelope disassembly|positive regulation of protein modification process|response to interleukin-1|fibroblast growth factor receptor signaling pathway|platelet aggregation|ribonucleotide metabolic process|regulation of MAPK cascade|nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|rhodopsin mediated signaling pathway|negative regulation of nucleotide metabolic process|regulation of protein secretion|cellular response to growth factor stimulus|regulation of platelet aggregation|adenyl nucleotide binding|regulation of blood vessel endothelial cell migration|phosphorylation|peptide transport|posttranscriptional regulation of gene expression|neurotrophin signaling pathway|ERK1 and ERK2 cascade|negative regulation of adenylate cyclase activity|regulation of endothelial cell proliferation|enzyme linked receptor protein signaling pathway|regulation of adenylate cyclase activity|nuclear envelope disassembly|detection of visible light|positive regulation of myeloid leukocyte differentiation|positive regulation of MAPK cascade|cellular response to light stimulus|purine nucleotide metabolic process|epithelial cell migration|regulation of apoptotic process|positive regulation of adenylate cyclase activity|transition metal ion binding|negative regulation of apoptotic process|positive regulation of endothelial cell proliferation|protein kinase activity|chromatin modification|phototransduction, visible light|myeloid cell differentiation|cellular protein modification process|nucleotide biosynthetic process|cellular response to lipid|cell-cell junction assembly|hormone secretion|desmosome organization|positive regulation of lipase activity|apoptotic process|cellular response to lipopolysaccharide|regulation of wound healing|lipopolysaccharide-mediated signaling pathway|neurotrophin TRK receptor signaling pathway|cardiac muscle hypertrophy|peptide hormone secretion|myeloid leukocyte differentiation|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|histone kinase activity|regulation of phospholipase activity|protein phosphorylation|negative regulation of glial cell apoptotic process|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|activation of adenylate cyclase activity|peptidyl-amino acid modification|protein serine/threonine kinase activity|histone H3-T6 phosphorylation|cyclic nucleotide metabolic process|desmosome assembly|positive regulation of protein phosphorylation|positive regulation of phospholipase activity|glial cell apoptotic process|regulation of ERK1 and ERK2 cascade|endothelial cell migration|positive regulation of macrophage differentiation|zinc ion binding|positive regulation of phosphorylation|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|cyclic nucleotide biosynthetic process|vascular endothelial growth factor receptor signaling pathway|negative regulation of cAMP biosynthetic process|positive regulation of phospholipase C activity|cAMP metabolic process|macrophage differentiation|positive regulation of cAMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|peptidyl-serine phosphorylation|regulation of cAMP metabolic process|peptidyl-threonine phosphorylation|positive regulation of cAMP metabolic process|negative regulation of cAMP metabolic process|protein kinase C activity|ERBB signaling pathway|blood vessel endothelial cell migration|histone kinase activity (H3-T6 specific)|cAMP biosynthetic process|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity K02677 classical protein kinase C alpha type[2.7.11.13] hsa05200|hsa04151|hsa05206|hsa04010|hsa04014|hsa04015|hsa05205|hsa04510|hsa04020|hsa05164|hsa04360|hsa04921|hsa04261|hsa05161|hsa04072|hsa04310|hsa04530|hsa04650|hsa04728|hsa04270|hsa04071|hsa04670|hsa04919|hsa04724|hsa04726|hsa04725|hsa04066|hsa05231|hsa04933|hsa04723|hsa04916|hsa04750|hsa04070|hsa05146|hsa04972|hsa04713|hsa04666|hsa05032|hsa04912|hsa04970|hsa04540|hsa04727|hsa04012|hsa04911|hsa04925|hsa04971|hsa04918|hsa05031|hsa04664|hsa04720|hsa05214|hsa04370|hsa04150|hsa04730|hsa05223|hsa05130|hsa05110|hsa04961|hsa04960|hsa05143 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Gap junction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Glioma - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human)|Vibrio cholerae infection - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)|Aldosterone-regulated sodium reabsorption - Homo sapiens (human)|African trypanosomiasis - Homo sapiens (human) 17:66302636-66810743 47 64 161 815 864 1222 0.279053475821387 0.345340551708951 0.861845958723585 4.33554067682886 4.20890963318184 6.79967561386851 0.495413328751308 5.11470864129307 -3.367947470451 1.14593805221113e-20 9.66407757364721e-19 DOWN ENSG00000103415 HMOX2 heme oxygenase 2 [Source:HGNC Symbol;Acc:HGNC:5014] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0044281|GO:0046483|GO:0043231|GO:0043169|GO:0042168|GO:0005737|GO:0016705|GO:0042592|GO:0019725|GO:0051186|GO:0006979|GO:0055085|GO:0005783|GO:0001666|GO:0016021|GO:0055114|GO:0046872|GO:0048878|GO:0042167|GO:0006778|GO:0004392|GO:0055082|GO:0006788|GO:0019439|GO:0050801|GO:0006873|GO:0030003|GO:0055065|GO:0006875|GO:0006879|GO:0055072 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|heme metabolic process|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|homeostatic process|cellular homeostasis|cofactor metabolic process|response to oxidative stress|transmembrane transport|endoplasmic reticulum|response to hypoxia|integral component of membrane|oxidation-reduction process|metal ion binding|chemical homeostasis|heme catabolic process|porphyrin-containing compound metabolic process|heme oxygenase (decyclizing) activity|cellular chemical homeostasis|heme oxidation|aromatic compound catabolic process|ion homeostasis|cellular ion homeostasis|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|cellular iron ion homeostasis|iron ion homeostasis - - - - 16:4474690-4510347 92 122 92 862 990 487 0.752349028436494 0.906711081346413 0.678317605432389 6.31588849929968 6.64251762919242 3.73239045707764 0.779125905071765 5.56359886185658 -2.83609001596949 1.20273765500466e-20 1.011451547958e-18 DOWN ENSG00000158125 XDH xanthine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:12805] GO:0032502|GO:0009055|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0009653|GO:0043227|GO:0048037|GO:0023057|GO:0009893|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0042802|GO:0048514|GO:0042127|GO:0045595|GO:0006725|GO:0009888|GO:0006810|GO:1901360|GO:0001568|GO:0010941|GO:0051536|GO:0007275|GO:0045596|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0019637|GO:0031325|GO:0046483|GO:0033554|GO:0090287|GO:0016614|GO:0010942|GO:0043231|GO:0043169|GO:0005737|GO:0072593|GO:0009966|GO:0043546|GO:0046983|GO:0050673|GO:0016903|GO:0010646|GO:0090288|GO:0006139|GO:0043085|GO:0055086|GO:0007154|GO:0007165|GO:0005783|GO:0009968|GO:0008219|GO:0050662|GO:0008285|GO:0050790|GO:0000166|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0048732|GO:0050878|GO:0055114|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0030879|GO:0010468|GO:0016528|GO:0046872|GO:0007166|GO:1902548|GO:0001944|GO:0043412|GO:0007589|GO:0072358|GO:0051345|GO:0010629|GO:0050660|GO:0051604|GO:0001935|GO:0036211|GO:0032269|GO:2000377|GO:0030856|GO:2001213|GO:0031098|GO:0001570|GO:0051247|GO:0070848|GO:0006508|GO:0050678|GO:0050680|GO:0007595|GO:0032270|GO:0012501|GO:0060429|GO:0006796|GO:1901342|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:2001212|GO:0046903|GO:0071310|GO:1902532|GO:0019439|GO:0051246|GO:0030154|GO:0043068|GO:0051537|GO:1902531|GO:0072359|GO:0046434|GO:0030857|GO:0016529|GO:0042803|GO:1900747|GO:1900746|GO:0043067|GO:2000379|GO:0051896|GO:0003158|GO:0043491|GO:0070304|GO:0051898|GO:0031401|GO:0043065|GO:0030855|GO:0043408|GO:0016485|GO:0005777|GO:0009117|GO:0030162|GO:0045862|GO:0071363|GO:0016310|GO:0052547|GO:0001936|GO:0004854|GO:0007167|GO:0006145|GO:0004855|GO:0043410|GO:0001937|GO:0006163|GO:0032872|GO:0042981|GO:0046914|GO:0006144|GO:0009166|GO:0006464|GO:0045601|GO:0010952|GO:0051403|GO:0045602|GO:0006915|GO:0005506|GO:0045446|GO:0006195|GO:0009115|GO:0010950|GO:1900744|GO:0043281|GO:0038066|GO:0006468|GO:0042325|GO:0035924|GO:0001932|GO:0042326|GO:0031638|GO:0032874|GO:0043280|GO:0001934|GO:0006919|GO:0001933|GO:0042327|GO:0007169|GO:0052548|GO:2001056|GO:1900745|GO:2000116|GO:0097202|GO:0038084 developmental process|electron carrier activity|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cofactor binding|negative regulation of signaling|positive regulation of metabolic process|extracellular space|regulation of developmental process|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|regulation of cell proliferation|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|transport|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|iron-sulfur cluster binding|multicellular organism development|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|regulation of cellular response to growth factor stimulus|oxidoreductase activity, acting on CH-OH group of donors|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|cytoplasm|reactive oxygen species metabolic process|regulation of signal transduction|molybdopterin cofactor binding|protein dimerization activity|epithelial cell proliferation|oxidoreductase activity, acting on the aldehyde or oxo group of donors|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|cell death|coenzyme binding|negative regulation of cell proliferation|regulation of catalytic activity|nucleotide binding|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|regulation of body fluid levels|oxidation-reduction process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|mammary gland development|regulation of gene expression|sarcoplasm|metal ion binding|cell surface receptor signaling pathway|negative regulation of cellular response to vascular endothelial growth factor stimulus|vasculature development|macromolecule modification|body fluid secretion|cardiovascular system development|positive regulation of hydrolase activity|negative regulation of gene expression|flavin adenine dinucleotide binding|protein maturation|endothelial cell proliferation|protein modification process|negative regulation of cellular protein metabolic process|regulation of reactive oxygen species metabolic process|regulation of epithelial cell differentiation|negative regulation of vasculogenesis|stress-activated protein kinase signaling cascade|vasculogenesis|positive regulation of protein metabolic process|response to growth factor|proteolysis|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|lactation|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of vasculogenesis|secretion|cellular response to organic substance|negative regulation of intracellular signal transduction|aromatic compound catabolic process|regulation of protein metabolic process|cell differentiation|positive regulation of programmed cell death|2 iron, 2 sulfur cluster binding|regulation of intracellular signal transduction|circulatory system development|organophosphate catabolic process|negative regulation of epithelial cell differentiation|sarcoplasmic reticulum|protein homodimerization activity|negative regulation of vascular endothelial growth factor signaling pathway|regulation of vascular endothelial growth factor signaling pathway|regulation of programmed cell death|positive regulation of reactive oxygen species metabolic process|regulation of protein kinase B signaling|endothelium development|protein kinase B signaling|positive regulation of stress-activated protein kinase signaling cascade|negative regulation of protein kinase B signaling|positive regulation of protein modification process|positive regulation of apoptotic process|epithelial cell differentiation|regulation of MAPK cascade|protein processing|peroxisome|nucleotide metabolic process|regulation of proteolysis|positive regulation of proteolysis|cellular response to growth factor stimulus|phosphorylation|regulation of peptidase activity|regulation of endothelial cell proliferation|xanthine dehydrogenase activity|enzyme linked receptor protein signaling pathway|purine nucleobase catabolic process|xanthine oxidase activity|positive regulation of MAPK cascade|negative regulation of endothelial cell proliferation|purine nucleotide metabolic process|regulation of stress-activated MAPK cascade|regulation of apoptotic process|transition metal ion binding|purine nucleobase metabolic process|nucleotide catabolic process|cellular protein modification process|regulation of endothelial cell differentiation|positive regulation of peptidase activity|stress-activated MAPK cascade|negative regulation of endothelial cell differentiation|apoptotic process|iron ion binding|endothelial cell differentiation|purine nucleotide catabolic process|xanthine catabolic process|positive regulation of endopeptidase activity|regulation of p38MAPK cascade|regulation of cysteine-type endopeptidase activity involved in apoptotic process|p38MAPK cascade|protein phosphorylation|regulation of phosphorylation|cellular response to vascular endothelial growth factor stimulus|regulation of protein phosphorylation|negative regulation of phosphorylation|zymogen activation|positive regulation of stress-activated MAPK cascade|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|positive regulation of p38MAPK cascade|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|vascular endothelial growth factor signaling pathway K00106 xanthine dehydrogenase/oxidase[1.17.3.2] hsa01100|hsa00230|hsa04146|hsa00983|hsa00232 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|Caffeine metabolism - Homo sapiens (human) 2:31334321-31414715 35 56 52 283 342 319 0.405333021383288 0.589405520043859 0.542958735343053 2.93650493855923 3.24968565742557 3.46231702881587 0.5125657589234 3.21616920826689 -2.64953430102111 1.31241735964529e-20 1.10058729929356e-18 DOWN ENSG00000122367 LDB3 LIM domain binding 3 [Source:HGNC Symbol;Acc:HGNC:15710] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0043229|GO:0043167|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0030017|GO:0031143|GO:0030018|GO:0048468|GO:0022607|GO:0061061|GO:0043169|GO:0019899|GO:0005737|GO:0031674|GO:0008092|GO:0048869|GO:0030029|GO:0006996|GO:0046872|GO:0007010|GO:0042692|GO:0042805|GO:0043292|GO:0048471|GO:0055001|GO:0030036|GO:0070925|GO:0019900|GO:0030154|GO:0030239|GO:0005856|GO:0055002|GO:0030016|GO:0051393|GO:0051146|GO:0046914|GO:0031032|GO:0019901|GO:0045214|GO:0005080|GO:0051371|GO:0008270 developmental process|cell|cellular process|binding|cell projection|intracellular organelle|ion binding|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|sarcomere|pseudopodium|Z disc|cell development|cellular component assembly|muscle structure development|cation binding|enzyme binding|cytoplasm|I band|cytoskeletal protein binding|cellular developmental process|actin filament-based process|organelle organization|metal ion binding|cytoskeleton organization|muscle cell differentiation|actinin binding|contractile fiber|perinuclear region of cytoplasm|muscle cell development|actin cytoskeleton organization|organelle assembly|kinase binding|cell differentiation|myofibril assembly|cytoskeleton|striated muscle cell development|myofibril|alpha-actinin binding|striated muscle cell differentiation|transition metal ion binding|actomyosin structure organization|protein kinase binding|sarcomere organization|protein kinase C binding|muscle alpha-actinin binding|zinc ion binding - - - - 10:86668449-86736068 1 4 2 122 92 299 0.00640364613361812 0.0232693157466544 0.0115424942533189 0.699683969340843 0.483168227653886 1.79367531935588 0.0137384853778638 0.992175838783536 -6.17430095978678 1.36675513085294e-20 1.14294419261859e-18 DOWN ENSG00000102174 PHEX phosphate regulating endopeptidase homolog, X-linked [Source:HGNC Symbol;Acc:HGNC:8918] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0048856|GO:0009888|GO:0007275|GO:0048513|GO:0019637|GO:0005887|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0007267|GO:0031226|GO:0007154|GO:0005783|GO:0001503|GO:0016021|GO:0019538|GO:0005794|GO:0046872|GO:0043412|GO:0031214|GO:0036211|GO:0048471|GO:0006508|GO:0044267|GO:0001501|GO:0030282|GO:0008237|GO:0004175|GO:0008238|GO:0046914|GO:0006464|GO:0004177|GO:0008270|GO:0004222 developmental process|signaling|cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|anatomical structure development|tissue development|multicellular organism development|animal organ development|organophosphate metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|cell-cell signaling|intrinsic component of plasma membrane|cell communication|endoplasmic reticulum|ossification|integral component of membrane|protein metabolic process|Golgi apparatus|metal ion binding|macromolecule modification|biomineral tissue development|protein modification process|perinuclear region of cytoplasm|proteolysis|cellular protein metabolic process|skeletal system development|bone mineralization|metallopeptidase activity|endopeptidase activity|exopeptidase activity|transition metal ion binding|cellular protein modification process|aminopeptidase activity|zinc ion binding|metalloendopeptidase activity - - - - X:22032441-22251310 14 12 8 158 130 124 0.151543403553666 0.118048603664703 0.0780756566141864 1.53234187005657 1.15454702225334 1.25791739527055 0.115889221277518 1.31493542919349 -3.50417366242802 1.55795443715928e-20 1.29919474209367e-18 DOWN ENSG00000162543 UBXN10 UBX domain protein 10 [Source:HGNC Symbol;Acc:HGNC:26354] GO:0005488|GO:0005515 binding|protein binding - - - - 1:20186085-20196048 63 69 94 419 408 502 0.799936524691355 0.796240220447615 1.07610902728121 4.76677645779952 4.25050574349373 5.97372189335634 0.89076192414006 4.9970013648832 -2.48795081596656 1.62140017796184e-20 1.3483365156789e-18 DOWN ENSG00000182197 EXT1 exostosin glycosyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3512] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0042802|GO:0006486|GO:0044262|GO:0006935|GO:0009888|GO:0048468|GO:0006082|GO:0007275|GO:0048513|GO:0044281|GO:0030900|GO:0007420|GO:0043231|GO:0031227|GO:0043169|GO:0005737|GO:0060322|GO:0005975|GO:0006928|GO:0046983|GO:0048598|GO:0021988|GO:0030176|GO:0007154|GO:0021772|GO:0007165|GO:0005783|GO:0001503|GO:0016757|GO:0030030|GO:0048869|GO:0016021|GO:0021537|GO:0044249|GO:0019538|GO:0031301|GO:0005794|GO:0006790|GO:0000902|GO:0031175|GO:0005976|GO:0034645|GO:0046872|GO:0043412|GO:0007417|GO:0015012|GO:0007498|GO:0046982|GO:0008194|GO:0007492|GO:0000904|GO:0009790|GO:0009100|GO:0036211|GO:0007369|GO:0016758|GO:0033692|GO:0030201|GO:0070085|GO:1901137|GO:0044267|GO:0032990|GO:0007399|GO:0097485|GO:0000139|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0016051|GO:0042803|GO:0048666|GO:0030182|GO:0007411|GO:0048706|GO:0009101|GO:0043413|GO:0009792|GO:0000271|GO:0008375|GO:0061564|GO:0015020|GO:0015014|GO:0006024|GO:0006029|GO:0030203|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0050508|GO:0050509|GO:0007409|GO:0048699|GO:0072498|GO:0042328|GO:0043009|GO:0030166 locomotion|developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|identical protein binding|protein glycosylation|cellular carbohydrate metabolic process|chemotaxis|tissue development|cell development|organic acid metabolic process|multicellular organism development|animal organ development|small molecule metabolic process|forebrain development|brain development|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cation binding|cytoplasm|head development|carbohydrate metabolic process|movement of cell or subcellular component|protein dimerization activity|embryonic morphogenesis|olfactory lobe development|integral component of endoplasmic reticulum membrane|cell communication|olfactory bulb development|signal transduction|endoplasmic reticulum|ossification|transferase activity, transferring glycosyl groups|cell projection organization|cellular developmental process|integral component of membrane|telencephalon development|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|Golgi apparatus|sulfur compound metabolic process|cell morphogenesis|neuron projection development|polysaccharide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|central nervous system development|heparan sulfate proteoglycan biosynthetic process|mesoderm development|protein heterodimerization activity|UDP-glycosyltransferase activity|endoderm development|cell morphogenesis involved in differentiation|embryo development|glycoprotein metabolic process|protein modification process|gastrulation|transferase activity, transferring hexosyl groups|cellular polysaccharide biosynthetic process|heparan sulfate proteoglycan metabolic process|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|cell part morphogenesis|nervous system development|neuron projection guidance|Golgi membrane|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|carbohydrate biosynthetic process|protein homodimerization activity|neuron development|neuron differentiation|axon guidance|embryonic skeletal system development|glycoprotein biosynthetic process|macromolecule glycosylation|embryo development ending in birth or egg hatching|polysaccharide biosynthetic process|acetylglucosaminyltransferase activity|axon development|glucuronosyltransferase activity|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|glycosaminoglycan metabolic process|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|axonogenesis|generation of neurons|embryonic skeletal joint development|heparan sulfate N-acetylglucosaminyltransferase activity|chordate embryonic development|proteoglycan biosynthetic process K02366 glucuronyl/N-acetylglucosaminyl transferase EXT1[2.4.1.225] hsa01100|hsa00534 Metabolic pathways - Homo sapiens (human)|Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human) 8:117794490-118111853 161 163 386 1487 1605 1633 1.23587635287806 1.13715254080805 2.67147700349366 10.2272549077446 10.1086554855587 11.7480447026198 1.68150196572659 10.694651698641 -2.66906712732132 1.64850545610496e-20 1.36706894129326e-18 DOWN ENSG00000164808 SPIDR scaffolding protein involved in DNA repair [Source:HGNC Symbol;Acc:HGNC:28971] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044089|GO:0071704|GO:0009628|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0019222|GO:0060341|GO:0006281|GO:0006725|GO:0009314|GO:0051130|GO:1901360|GO:2001022|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0043231|GO:0010243|GO:0032880|GO:0045184|GO:0006139|GO:0008104|GO:0010035|GO:0031334|GO:0043254|GO:0010033|GO:0031323|GO:0000725|GO:0072594|GO:0071417|GO:0006302|GO:0070201|GO:0045739|GO:0043279|GO:0031981|GO:2001020|GO:0071478|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0006461|GO:0034613|GO:0006282|GO:0014070|GO:0051054|GO:0010212|GO:0071241|GO:0071310|GO:1903827|GO:0005634|GO:0097305|GO:0006974|GO:0071312|GO:0000724|GO:0072711|GO:0033365|GO:2000781|GO:2000779|GO:0070202|GO:0071407|GO:0000018|GO:1901563|GO:0006310|GO:0071479|GO:0010569|GO:0072757|GO:0034502 cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|regulation of metabolic process|regulation of cellular localization|DNA repair|cellular aromatic compound metabolic process|response to radiation|positive regulation of cellular component organization|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|response to organonitrogen compound|regulation of protein localization|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|response to inorganic substance|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|regulation of cellular metabolic process|recombinational repair|establishment of protein localization to organelle|cellular response to organonitrogen compound|double-strand break repair|regulation of establishment of protein localization|positive regulation of DNA repair|response to alkaloid|nuclear lumen|regulation of response to DNA damage stimulus|cellular response to radiation|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|protein complex assembly|cellular protein localization|regulation of DNA repair|response to organic cyclic compound|positive regulation of DNA metabolic process|response to ionizing radiation|cellular response to inorganic substance|cellular response to organic substance|regulation of cellular protein localization|nucleus|response to alcohol|cellular response to DNA damage stimulus|cellular response to alkaloid|double-strand break repair via homologous recombination|cellular response to hydroxyurea|protein localization to organelle|positive regulation of double-strand break repair|regulation of double-strand break repair|regulation of establishment of protein localization to chromosome|cellular response to organic cyclic compound|regulation of DNA recombination|response to camptothecin|DNA recombination|cellular response to ionizing radiation|regulation of double-strand break repair via homologous recombination|cellular response to camptothecin|protein localization to chromosome - - - - 8:47260575-47736306 67 94 135 541 573 564 0.314720806882808 0.401288690844846 0.571738056997028 2.27690119353043 2.20837196577777 2.4828929553961 0.429249184908227 2.32272203823477 -2.4359292163143 1.66451709192024e-20 1.37652335906335e-18 DOWN ENSG00000115183 TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [Source:HGNC Symbol;Acc:HGNC:29364] GO:0032502|GO:0045202|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0042995|GO:0060076|GO:0043229|GO:0009628|GO:0044297|GO:0009653|GO:0016043|GO:0044708|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0048646|GO:0006949|GO:0043025|GO:0009314|GO:0050877|GO:0007632|GO:0045211|GO:0061061|GO:0043005|GO:0036477|GO:0014069|GO:0044306|GO:0007611|GO:0030030|GO:0048869|GO:0043954|GO:0030424|GO:0007612|GO:0042692|GO:0097061|GO:0043679|GO:0030425|GO:0097062|GO:0050890|GO:0030154|GO:0009416|GO:0008542|GO:0007520|GO:0008306|GO:0051146|GO:0014902 developmental process|synapse|behavior|cell|membrane|cellular process|cell junction|response to stimulus|binding|cell projection|excitatory synapse|intracellular organelle|response to abiotic stimulus|cell body|anatomical structure morphogenesis|cellular component organization|single-organism behavior|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|synaptic membrane|anatomical structure formation involved in morphogenesis|syncytium formation|neuronal cell body|response to radiation|neurological system process|visual behavior|postsynaptic membrane|muscle structure development|neuron projection|somatodendritic compartment|postsynaptic density|neuron projection terminus|learning or memory|cell projection organization|cellular developmental process|cellular component maintenance|axon|learning|muscle cell differentiation|dendritic spine organization|axon terminus|dendrite|dendritic spine maintenance|cognition|cell differentiation|response to light stimulus|visual learning|myoblast fusion|associative learning|striated muscle cell differentiation|myotube differentiation - - - - 2:158968634-159232659 137 127 244 842 928 1133 0.439418192621132 0.370205758080153 0.705606429540023 2.41973712637243 2.44216136114563 3.405785742156 0.505076793413769 2.75589474322469 -2.44794612637655 1.66919202903997e-20 1.37657621091048e-18 DOWN ENSG00000187741 FANCA Fanconi anemia complementation group A [Source:HGNC Symbol;Acc:HGNC:3582] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0044237|GO:0003006|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0045137|GO:0042127|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0046483|GO:0033554|GO:0022607|GO:0043231|GO:0048608|GO:0005737|GO:0007548|GO:0006139|GO:0008406|GO:0007126|GO:0043240|GO:0006996|GO:0008584|GO:0008585|GO:0046661|GO:0061458|GO:0046545|GO:0036297|GO:0007140|GO:0031981|GO:0005654|GO:0006259|GO:0006461|GO:0005634|GO:0006974|GO:0046546 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|cellular metabolic process|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|anatomical structure development|development of primary sexual characteristics|regulation of cell proliferation|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|sex differentiation|nucleobase-containing compound metabolic process|gonad development|meiotic nuclear division|Fanconi anaemia nuclear complex|organelle organization|male gonad development|female gonad development|male sex differentiation|reproductive system development|development of primary female sexual characteristics|interstrand cross-link repair|male meiosis|nuclear lumen|nucleoplasm|DNA metabolic process|protein complex assembly|nucleus|cellular response to DNA damage stimulus|development of primary male sexual characteristics K10888 fanconi anemia group A protein[-] hsa03460 Fanconi anemia pathway - Homo sapiens (human) 16:89737549-89816657 66 68 91 483 529 358 0.255478490611009 0.239221655979902 0.31758979209897 1.6751610954691 1.68010264444378 1.29874458513407 0.270763312896627 1.55133610834898 -2.51840711155173 1.74010310024958e-20 1.43110297396283e-18 DOWN ENSG00000179598 PLD6 phospholipase D family member 6 [Source:HGNC Symbol;Acc:HGNC:30447] GO:0032502|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0009892|GO:0043046|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0009056|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0009653|GO:0016043|GO:0043227|GO:0019867|GO:0032504|GO:0016787|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0031090|GO:0048609|GO:0019222|GO:0042802|GO:0007049|GO:0044255|GO:0006725|GO:0048468|GO:0009994|GO:0022402|GO:0051130|GO:1901360|GO:0007275|GO:0034641|GO:0016788|GO:0010636|GO:0044281|GO:0016772|GO:0019637|GO:0046483|GO:0051128|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0007389|GO:0048515|GO:0046983|GO:0031966|GO:0007028|GO:0016458|GO:0006139|GO:0061024|GO:0007276|GO:0006629|GO:0007126|GO:0048869|GO:0016021|GO:0044249|GO:0007281|GO:0006996|GO:0061025|GO:0005740|GO:0008053|GO:0030719|GO:0010468|GO:0007286|GO:0008654|GO:0046486|GO:0048232|GO:0046872|GO:0043412|GO:0031047|GO:0010629|GO:0016042|GO:0007005|GO:0005741|GO:0009798|GO:0009880|GO:0048477|GO:0009790|GO:0016780|GO:0006306|GO:0003002|GO:0004518|GO:0006259|GO:0005739|GO:0016298|GO:0006796|GO:0033043|GO:0010467|GO:0008610|GO:0030154|GO:0048599|GO:0048469|GO:0016070|GO:0010635|GO:0007292|GO:0042803|GO:0042578|GO:0006644|GO:0048284|GO:0010638|GO:0004620|GO:0007283|GO:0090501|GO:0000578|GO:0008081|GO:0046474|GO:0034660|GO:0010822|GO:0006304|GO:0010821|GO:0009948|GO:0004519|GO:0009952|GO:0004540|GO:0090305|GO:0006650|GO:0035282|GO:0034587|GO:0008595|GO:0006655|GO:0008808|GO:0090502|GO:0004521|GO:0035755|GO:0032049|GO:0032048 developmental process|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|binding|catalytic activity|methylation|negative regulation of metabolic process|DNA methylation involved in gamete generation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|catabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|outer membrane|multicellular organism reproduction|hydrolase activity|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|transferase activity|anatomical structure development|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|identical protein binding|cell cycle|cellular lipid metabolic process|cellular aromatic compound metabolic process|cell development|oocyte differentiation|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|positive regulation of mitochondrial fusion|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|pattern specification process|spermatid differentiation|protein dimerization activity|mitochondrial membrane|cytoplasm organization|gene silencing|nucleobase-containing compound metabolic process|membrane organization|gamete generation|lipid metabolic process|meiotic nuclear division|cellular developmental process|integral component of membrane|cellular biosynthetic process|germ cell development|organelle organization|membrane fusion|mitochondrial envelope|mitochondrial fusion|P granule organization|regulation of gene expression|spermatid development|phospholipid biosynthetic process|glycerolipid metabolic process|male gamete generation|metal ion binding|macromolecule modification|gene silencing by RNA|negative regulation of gene expression|lipid catabolic process|mitochondrion organization|mitochondrial outer membrane|axis specification|embryonic pattern specification|oogenesis|embryo development|phosphotransferase activity, for other substituted phosphate groups|DNA methylation|regionalization|nuclease activity|DNA metabolic process|mitochondrion|lipase activity|phosphate-containing compound metabolic process|regulation of organelle organization|gene expression|lipid biosynthetic process|cell differentiation|oocyte development|cell maturation|RNA metabolic process|regulation of mitochondrial fusion|female gamete generation|protein homodimerization activity|phosphoric ester hydrolase activity|phospholipid metabolic process|organelle fusion|positive regulation of organelle organization|phospholipase activity|spermatogenesis|RNA phosphodiester bond hydrolysis|embryonic axis specification|phosphoric diester hydrolase activity|glycerophospholipid biosynthetic process|ncRNA metabolic process|positive regulation of mitochondrion organization|DNA modification|regulation of mitochondrion organization|anterior/posterior axis specification|endonuclease activity|anterior/posterior pattern specification|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|glycerophospholipid metabolic process|segmentation|piRNA metabolic process|anterior/posterior axis specification, embryo|phosphatidylglycerol biosynthetic process|cardiolipin synthase activity|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|cardiolipin hydrolase activity|cardiolipin biosynthetic process|cardiolipin metabolic process - - - - 17:17200995-17206315 745 795 496 130 126 122 20.5855167660225 19.964256416732 12.3566846914551 3.2184587367345 2.85657348546329 3.15931569163564 17.6354859580699 3.07811597127781 2.51836183791056 1.8103419051831e-20 1.48477877025649e-18 UP ENSG00000134109 EDEM1 ER degradation enhancer, mannosidase alpha-like 1 [Source:HGNC Symbol;Acc:HGNC:18967] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0006457|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:1903829|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:0006486|GO:0006810|GO:0016798|GO:0033554|GO:0043231|GO:0031227|GO:0043169|GO:0005737|GO:1904294|GO:0032880|GO:0005975|GO:0051222|GO:0045184|GO:0032388|GO:0051787|GO:0030176|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0051649|GO:0090316|GO:0001948|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0010033|GO:0036503|GO:0009311|GO:0045732|GO:0034645|GO:0046872|GO:0030968|GO:0043412|GO:0006487|GO:0030163|GO:0030970|GO:0070863|GO:0032386|GO:0051223|GO:0015031|GO:0044265|GO:0009100|GO:0036211|GO:0070201|GO:0046907|GO:0006986|GO:0030433|GO:1904154|GO:0044322|GO:0051247|GO:0006508|GO:0070085|GO:0097466|GO:0034613|GO:0004553|GO:1901137|GO:0044267|GO:0042176|GO:1904292|GO:0071310|GO:0051246|GO:0009059|GO:0035967|GO:1903827|GO:0034976|GO:0034620|GO:0044257|GO:0009101|GO:0043413|GO:1904382|GO:0033157|GO:0010498|GO:0006491|GO:0036498|GO:0032527|GO:0018279|GO:0006516|GO:0005509|GO:0016482|GO:0006886|GO:1904152|GO:0051603|GO:0006464|GO:0015923|GO:0019941|GO:0018193|GO:0006517|GO:0070861|GO:0043687|GO:0043161|GO:0004559|GO:0006511|GO:0036508|GO:0004571|GO:1904380|GO:0036510 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|protein folding|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|positive regulation of cellular protein localization|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|protein glycosylation|transport|hydrolase activity, acting on glycosyl bonds|cellular response to stress|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cation binding|cytoplasm|positive regulation of ERAD pathway|regulation of protein localization|carbohydrate metabolic process|positive regulation of protein transport|establishment of protein localization|positive regulation of intracellular transport|misfolded protein binding|integral component of endoplasmic reticulum membrane|protein localization|cell communication|signal transduction|endoplasmic reticulum|establishment of localization in cell|positive regulation of intracellular protein transport|glycoprotein binding|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|response to organic substance|ERAD pathway|oligosaccharide metabolic process|positive regulation of protein catabolic process|cellular macromolecule biosynthetic process|metal ion binding|endoplasmic reticulum unfolded protein response|macromolecule modification|protein N-linked glycosylation|protein catabolic process|retrograde protein transport, ER to cytosol|positive regulation of protein exit from endoplasmic reticulum|regulation of intracellular transport|regulation of protein transport|protein transport|cellular macromolecule catabolic process|glycoprotein metabolic process|protein modification process|regulation of establishment of protein localization|intracellular transport|response to unfolded protein|ER-associated ubiquitin-dependent protein catabolic process|positive regulation of retrograde protein transport, ER to cytosol|endoplasmic reticulum quality control compartment|positive regulation of protein metabolic process|proteolysis|glycosylation|glycoprotein ERAD pathway|cellular protein localization|hydrolase activity, hydrolyzing O-glycosyl compounds|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of protein catabolic process|regulation of ERAD pathway|cellular response to organic substance|regulation of protein metabolic process|macromolecule biosynthetic process|cellular response to topologically incorrect protein|regulation of cellular protein localization|response to endoplasmic reticulum stress|cellular response to unfolded protein|cellular protein catabolic process|glycoprotein biosynthetic process|macromolecule glycosylation|mannose trimming involved in glycoprotein ERAD pathway|regulation of intracellular protein transport|proteasomal protein catabolic process|N-glycan processing|IRE1-mediated unfolded protein response|protein exit from endoplasmic reticulum|protein N-linked glycosylation via asparagine|glycoprotein catabolic process|calcium ion binding|cytosolic transport|intracellular protein transport|regulation of retrograde protein transport, ER to cytosol|proteolysis involved in cellular protein catabolic process|cellular protein modification process|mannosidase activity|modification-dependent protein catabolic process|peptidyl-amino acid modification|protein deglycosylation|regulation of protein exit from endoplasmic reticulum|post-translational protein modification|proteasome-mediated ubiquitin-dependent protein catabolic process|alpha-mannosidase activity|ubiquitin-dependent protein catabolic process|protein alpha-1,2-demannosylation|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|endoplasmic reticulum mannose trimming|trimming of terminal mannose on C branch K10084 ER degradation enhancer, mannosidase alpha-like 1[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 3:5187646-5219957 429 541 762 2397 2606 2420 3.33914206812985 3.82696532234094 5.34744799766447 16.7164179468228 16.6425443099275 17.6531328790375 4.17118512937842 17.0040317119293 -2.02734760488822 2.02669931944588e-20 1.65767346528047e-18 DOWN ENSG00000124171 PARD6B par-6 family cell polarity regulator beta [Source:HGNC Symbol;Acc:HGNC:16245] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0005488|GO:1903561|GO:0050794|GO:0040012|GO:0043229|GO:0045177|GO:0048870|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0007049|GO:0048468|GO:0005938|GO:0007275|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0006928|GO:0007163|GO:0051270|GO:0016477|GO:0070062|GO:0030030|GO:0051301|GO:0048869|GO:2000145|GO:0043296|GO:0000902|GO:0005829|GO:0031175|GO:0045216|GO:0000904|GO:0030334|GO:0034329|GO:0006461|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0005923|GO:0005634|GO:0048666|GO:0030182|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0007043|GO:0070830|GO:0043297|GO:0007409|GO:0048699 locomotion|developmental process|macromolecular complex|cell|membrane|cellular process|extracellular region|cell junction|binding|extracellular vesicle|regulation of cellular process|regulation of locomotion|intracellular organelle|apical part of cell|cell motility|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cell cycle|cell development|cell cortex|multicellular organism development|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|establishment or maintenance of cell polarity|regulation of cellular component movement|cell migration|extracellular exosome|cell projection organization|cell division|cellular developmental process|regulation of cell motility|apical junction complex|cell morphogenesis|cytosol|neuron projection development|cell-cell junction organization|cell morphogenesis involved in differentiation|regulation of cell migration|cell junction assembly|protein complex assembly|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|bicellular tight junction|nucleus|neuron development|neuron differentiation|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|cell-cell junction assembly|bicellular tight junction assembly|apical junction assembly|axonogenesis|generation of neurons K06093 partitioning defective protein 6[-] hsa04144|hsa04015|hsa04360|hsa04390|hsa04530 Endocytosis - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human) 20:50731544-50756795 815 876 1351 190 211 290 11.7318960869322 11.4602640355272 17.5339666621306 2.45054482825118 2.49207406950457 3.91234508120714 13.5753755948633 2.9516546596543 2.20139627149823 2.5745968504798e-20 2.1000550375471e-18 UP ENSG00000275700 AATF apoptosis antagonizing transcription factor [Source:HGNC Symbol;Acc:HGNC:19235] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0030055|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0007155|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:1901360|GO:0010941|GO:0007275|GO:0003676|GO:0034641|GO:0005924|GO:0005912|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0043231|GO:0005737|GO:0072593|GO:0009890|GO:0019904|GO:0060548|GO:0006139|GO:0007154|GO:0007165|GO:0008092|GO:0008219|GO:0051301|GO:0044249|GO:0022613|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0005794|GO:0005730|GO:0005813|GO:0010468|GO:0034645|GO:0003723|GO:0007166|GO:0042984|GO:0043069|GO:0051252|GO:0005815|GO:0030275|GO:0009790|GO:0042254|GO:0010628|GO:0009100|GO:2000377|GO:0000278|GO:0048156|GO:0031981|GO:0007346|GO:0070848|GO:2000378|GO:0012501|GO:0042982|GO:1903019|GO:1901137|GO:0010467|GO:0071310|GO:0031328|GO:0040016|GO:0051246|GO:0009059|GO:0043068|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0042985|GO:0043067|GO:0006974|GO:0005925|GO:0097190|GO:0006801|GO:0009101|GO:0042554|GO:0045893|GO:0043065|GO:0032774|GO:2001141|GO:0071363|GO:0038179|GO:0007167|GO:0015630|GO:0032929|GO:0042981|GO:0010559|GO:0043066|GO:0043522|GO:0044822|GO:0006351|GO:0006915|GO:0006355|GO:0048011|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0032928|GO:0007169 developmental process|signaling|cell|cellular process|metabolic process|cell junction|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|cell-substrate adherens junction|adherens junction|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|reactive oxygen species metabolic process|negative regulation of biosynthetic process|protein domain specific binding|negative regulation of cell death|nucleobase-containing compound metabolic process|cell communication|signal transduction|cytoskeletal protein binding|cell death|cell division|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|nucleolus|centrosome|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|cell surface receptor signaling pathway|regulation of amyloid precursor protein biosynthetic process|negative regulation of programmed cell death|regulation of RNA metabolic process|microtubule organizing center|LRR domain binding|embryo development|ribosome biogenesis|positive regulation of gene expression|glycoprotein metabolic process|regulation of reactive oxygen species metabolic process|mitotic cell cycle|tau protein binding|nuclear lumen|regulation of mitotic cell cycle|response to growth factor|negative regulation of reactive oxygen species metabolic process|programmed cell death|amyloid precursor protein metabolic process|negative regulation of glycoprotein metabolic process|carbohydrate derivative biosynthetic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|embryonic cleavage|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of programmed cell death|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|negative regulation of amyloid precursor protein biosynthetic process|regulation of programmed cell death|cellular response to DNA damage stimulus|focal adhesion|apoptotic signaling pathway|superoxide metabolic process|glycoprotein biosynthetic process|superoxide anion generation|positive regulation of transcription, DNA-templated|positive regulation of apoptotic process|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|neurotrophin signaling pathway|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|negative regulation of superoxide anion generation|regulation of apoptotic process|regulation of glycoprotein biosynthetic process|negative regulation of apoptotic process|leucine zipper domain binding|poly(A) RNA binding|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|neurotrophin TRK receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|regulation of superoxide anion generation|transmembrane receptor protein tyrosine kinase signaling pathway - - - - 17:36948875-37056871 163 144 274 1184 1354 837 1.65996746020969 1.33276295700921 2.515795998938 10.8034017961737 11.3135138614219 7.98850418074285 1.8361754720523 10.0351399461128 -2.45028489611007 2.73991188408678e-20 2.22881006505522e-18 DOWN ENSG00000183853 KIRREL kin of IRRE like (Drosophila) [Source:HGNC Symbol;Acc:HGNC:15734] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0005488|GO:1903561|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0044089|GO:0071704|GO:0044237|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0016337|GO:0043198|GO:0051130|GO:0032535|GO:0031982|GO:0051128|GO:0022607|GO:0098609|GO:0005737|GO:0032970|GO:0043005|GO:0036477|GO:0070062|GO:0008092|GO:0007588|GO:0031253|GO:0016021|GO:0030029|GO:0019538|GO:0031334|GO:0043254|GO:0098857|GO:0031324|GO:0031323|GO:0006996|GO:0032268|GO:0032956|GO:0043412|GO:0007010|GO:0017022|GO:0036211|GO:0032269|GO:0030425|GO:0048471|GO:0006461|GO:0030036|GO:0006796|GO:0032273|GO:0033043|GO:0044267|GO:0051174|GO:0051246|GO:0030832|GO:0045121|GO:0010638|GO:0034622|GO:0030838|GO:0043623|GO:0016310|GO:0008064|GO:0051493|GO:0006464|GO:0007015|GO:0051495|GO:0030833|GO:0051258|GO:0006468|GO:0042325|GO:0001932|GO:0042326|GO:0001933|GO:0008154|GO:0030041 cell|membrane|cellular process|extracellular region|metabolic process|cell junction|binding|extracellular vesicle|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|positive regulation of cellular component biogenesis|organic substance metabolic process|cellular metabolic process|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|regulation of metabolic process|single organismal cell-cell adhesion|dendritic shaft|positive regulation of cellular component organization|regulation of cellular component size|vesicle|regulation of cellular component organization|cellular component assembly|cell-cell adhesion|cytoplasm|regulation of actin filament-based process|neuron projection|somatodendritic compartment|extracellular exosome|cytoskeletal protein binding|excretion|cell projection membrane|integral component of membrane|actin filament-based process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|regulation of actin cytoskeleton organization|macromolecule modification|cytoskeleton organization|myosin binding|protein modification process|negative regulation of cellular protein metabolic process|dendrite|perinuclear region of cytoplasm|protein complex assembly|actin cytoskeleton organization|phosphate-containing compound metabolic process|positive regulation of protein polymerization|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of actin filament length|membrane raft|positive regulation of organelle organization|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|cellular protein complex assembly|phosphorylation|regulation of actin polymerization or depolymerization|regulation of cytoskeleton organization|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|protein polymerization|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|actin polymerization or depolymerization|actin filament polymerization - - - - 1:157993273-158100262 34 48 105 588 566 487 0.144215006424141 0.185032709707701 0.401542758815769 2.23461407738669 1.9697550640765 1.93591038278597 0.243596824982537 2.04675984141639 -3.07077459771533 2.89438635651254e-20 2.34807093172079e-18 DOWN ENSG00000188342 GTF2F2 general transcription factor IIF subunit 2 [Source:HGNC Symbol;Acc:HGNC:4653] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0044089|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0016032|GO:0006725|GO:0051130|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0048524|GO:0031325|GO:0046483|GO:0051128|GO:0016817|GO:0022607|GO:0043231|GO:0005667|GO:0006139|GO:0000991|GO:0000166|GO:0044249|GO:0031334|GO:0043254|GO:0050792|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0035639|GO:0044798|GO:0051252|GO:2000144|GO:0001883|GO:0010628|GO:0016818|GO:0019083|GO:0032549|GO:0031981|GO:1990234|GO:0005654|GO:0006461|GO:2000142|GO:1903902|GO:0010467|GO:0019058|GO:0017076|GO:0031328|GO:0009059|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0045893|GO:0034622|GO:0006396|GO:0060261|GO:0046782|GO:0032774|GO:0005524|GO:2001141|GO:0005675|GO:0030554|GO:0005674|GO:0015630|GO:0016071|GO:0065004|GO:0090575|GO:0050434|GO:0016591|GO:0016462|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0032784|GO:0006352|GO:0032786|GO:0006357|GO:1902911|GO:1903506|GO:0017111|GO:0045898|GO:0006354|GO:0006397|GO:0045899|GO:0008380|GO:0006367|GO:0051123|GO:0006368|GO:0000375|GO:1902554|GO:0006370|GO:0032968|GO:0034243|GO:0004386|GO:0009452|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|transcription factor complex|nucleobase-containing compound metabolic process|transcription factor activity, core RNA polymerase II binding|nucleotide binding|cellular biosynthetic process|positive regulation of protein complex assembly|regulation of protein complex assembly|regulation of viral process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|nuclear transcription factor complex|regulation of RNA metabolic process|positive regulation of DNA-templated transcription, initiation|purine nucleoside binding|positive regulation of gene expression|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|viral transcription|ribonucleoside binding|nuclear lumen|transferase complex|nucleoplasm|protein complex assembly|regulation of DNA-templated transcription, initiation|positive regulation of viral life cycle|gene expression|viral life cycle|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|cellular macromolecular complex assembly|RNA processing|positive regulation of transcription initiation from RNA polymerase II promoter|regulation of viral transcription|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|holo TFIIH complex|adenyl nucleotide binding|transcription factor TFIIF complex|microtubule cytoskeleton|mRNA metabolic process|protein-DNA complex assembly|RNA polymerase II transcription factor complex|positive regulation of viral transcription|DNA-directed RNA polymerase II, holoenzyme|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|DNA-templated transcription, initiation|positive regulation of DNA-templated transcription, elongation|regulation of transcription from RNA polymerase II promoter|protein kinase complex|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|regulation of RNA polymerase II transcriptional preinitiation complex assembly|DNA-templated transcription, elongation|mRNA processing|positive regulation of RNA polymerase II transcriptional preinitiation complex assembly|RNA splicing|transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|RNA splicing, via transesterification reactions|serine/threonine protein kinase complex|7-methylguanosine mRNA capping|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription elongation from RNA polymerase II promoter|helicase activity|7-methylguanosine RNA capping|mRNA splicing, via spliceosome K03139 transcription initiation factor TFIIF subunit beta[3.6.4.12] hsa03022 Basal transcription factors - Homo sapiens (human) 13:45120515-45284909 190 190 302 1027 1177 914 3.4172319625455 3.10566676710481 4.89715343618899 16.5496881639725 17.3686629399628 15.4062514834167 3.80668405527977 16.441534195784 -2.11073818624961 3.15871550869411e-20 2.55556349042152e-18 DOWN ENSG00000138078 PREPL prolyl endopeptidase-like [Source:HGNC Symbol;Acc:HGNC:30228] GO:0005623|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0043227|GO:0016787|GO:0005622|GO:0012505|GO:0043231|GO:0008233|GO:0005737|GO:0019538|GO:0005794|GO:0017171|GO:0005829|GO:0006508|GO:0008236|GO:0005856|GO:0004252|GO:0004175|GO:0008238|GO:0070008 cell|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|endomembrane system|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|protein metabolic process|Golgi apparatus|serine hydrolase activity|cytosol|proteolysis|serine-type peptidase activity|cytoskeleton|serine-type endopeptidase activity|endopeptidase activity|exopeptidase activity|serine-type exopeptidase activity - - - - 2:44316281-44361862 366 441 523 1765 1963 1601 1.17749928303582 1.28943151141709 1.51703674170462 5.08770882501745 5.18165029730688 4.82725274096296 1.32798917871918 5.0322039544291 -1.92194700484634 3.17837822496214e-20 2.56452171697351e-18 DOWN ENSG00000087074 PPP1R15A protein phosphatase 1 regulatory subunit 15A [Source:HGNC Symbol;Acc:HGNC:14375] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009628|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0043227|GO:0019867|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0008287|GO:0030234|GO:0050793|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0048514|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:0009314|GO:0022402|GO:0000164|GO:1901360|GO:0001568|GO:0010941|GO:0009991|GO:0007275|GO:0019208|GO:0034641|GO:0008047|GO:0031325|GO:0046483|GO:0033554|GO:0090287|GO:0010942|GO:0045786|GO:0043231|GO:0006413|GO:0019899|GO:0010243|GO:1903573|GO:0005737|GO:0031668|GO:0035902|GO:0071559|GO:0009966|GO:0031966|GO:0009890|GO:1903917|GO:0036496|GO:0060548|GO:0042493|GO:0010646|GO:0090288|GO:0006139|GO:0043085|GO:0001525|GO:0008104|GO:0007154|GO:0044092|GO:0007165|GO:0005783|GO:0009968|GO:0008219|GO:0008285|GO:1902074|GO:0050790|GO:0010998|GO:0090648|GO:0043086|GO:0010035|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0042594|GO:0005794|GO:0007568|GO:0009636|GO:0036492|GO:0032268|GO:0005740|GO:0005829|GO:0009743|GO:0010468|GO:0034645|GO:0043555|GO:0006518|GO:0090101|GO:0007166|GO:0014074|GO:0030968|GO:0001944|GO:0043412|GO:0072358|GO:0051345|GO:0010629|GO:1904312|GO:0043620|GO:0006984|GO:0005741|GO:0051252|GO:1990268|GO:0006446|GO:0051604|GO:0007050|GO:1900101|GO:0071417|GO:0010628|GO:1903912|GO:0036211|GO:0032269|GO:0071560|GO:0019902|GO:0043279|GO:0006986|GO:0045765|GO:0097237|GO:0071478|GO:0051247|GO:0051346|GO:0070848|GO:0006508|GO:0005739|GO:0009267|GO:0071453|GO:0034613|GO:0046677|GO:0019900|GO:0032270|GO:0012501|GO:0014070|GO:0006796|GO:0043603|GO:1901342|GO:0035556|GO:0060359|GO:0044267|GO:0051174|GO:0019211|GO:0045948|GO:0010467|GO:0060734|GO:0071310|GO:0019888|GO:0031328|GO:0051246|GO:0035690|GO:0009059|GO:0043068|GO:0031669|GO:0035967|GO:0016070|GO:1900102|GO:0072359|GO:0031667|GO:0034976|GO:0010557|GO:0009416|GO:0042220|GO:0043067|GO:0006974|GO:0097190|GO:1903898|GO:0034620|GO:0070059|GO:0071322|GO:0045893|GO:1990441|GO:0010923|GO:0097193|GO:0016311|GO:0043043|GO:1903897|GO:0071236|GO:0033365|GO:0031401|GO:0043065|GO:0009411|GO:0016485|GO:0045892|GO:1904314|GO:0010922|GO:0032774|GO:0030162|GO:2001141|GO:0032058|GO:0045727|GO:0071363|GO:0016310|GO:0010608|GO:1902679|GO:0071407|GO:0007179|GO:0036499|GO:0030512|GO:1904308|GO:0006412|GO:0019903|GO:0007167|GO:0006417|GO:0043558|GO:0071482|GO:0042981|GO:0090650|GO:0045861|GO:1904310|GO:0072703|GO:0008599|GO:0019901|GO:0072542|GO:0006464|GO:0072732|GO:0017015|GO:0006351|GO:0006915|GO:0006355|GO:0043618|GO:0010921|GO:0036294|GO:0045943|GO:0006470|GO:0070972|GO:0035304|GO:0006366|GO:0097201|GO:1903507|GO:0006357|GO:0010955|GO:0006360|GO:0006468|GO:0035307|GO:1903506|GO:0043666|GO:0032516|GO:0008157|GO:0042325|GO:0070613|GO:0001932|GO:0018193|GO:0042326|GO:0001934|GO:0035306|GO:0007178|GO:0035305|GO:0006356|GO:0001933|GO:0000122|GO:0034644|GO:0032515|GO:0042327|GO:0035303|GO:0071862|GO:0035308|GO:0033138|GO:0018105|GO:1902310|GO:0070262|GO:0010801|GO:0033135|GO:0018107 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|outer membrane|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|protein serine/threonine phosphatase complex|enzyme regulator activity|regulation of developmental process|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|response to radiation|cell cycle process|protein phosphatase type 1 complex|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to extracellular stimulus|multicellular organism development|phosphatase regulator activity|cellular nitrogen compound metabolic process|enzyme activator activity|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|regulation of cellular response to growth factor stimulus|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|translational initiation|enzyme binding|response to organonitrogen compound|negative regulation of response to endoplasmic reticulum stress|cytoplasm|cellular response to extracellular stimulus|response to immobilization stress|response to transforming growth factor beta|regulation of signal transduction|mitochondrial membrane|negative regulation of biosynthetic process|positive regulation of endoplasmic reticulum stress-induced eIF2 alpha dephosphorylation|regulation of translational initiation by eIF2 alpha dephosphorylation|negative regulation of cell death|response to drug|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|angiogenesis|protein localization|cell communication|negative regulation of molecular function|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|cell death|negative regulation of cell proliferation|response to salt|regulation of catalytic activity|regulation of translational initiation by eIF2 alpha phosphorylation|response to environmental enrichment|negative regulation of catalytic activity|response to inorganic substance|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to starvation|Golgi apparatus|aging|response to toxic substance|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|regulation of cellular protein metabolic process|mitochondrial envelope|cytosol|response to carbohydrate|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of translation in response to stress|peptide metabolic process|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|response to purine-containing compound|endoplasmic reticulum unfolded protein response|vasculature development|macromolecule modification|cardiovascular system development|positive regulation of hydrolase activity|negative regulation of gene expression|cellular response to gold(3+)|regulation of DNA-templated transcription in response to stress|ER-nucleus signaling pathway|mitochondrial outer membrane|regulation of RNA metabolic process|response to gold nanoparticle|regulation of translational initiation|protein maturation|cell cycle arrest|regulation of endoplasmic reticulum unfolded protein response|cellular response to organonitrogen compound|positive regulation of gene expression|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|phosphatase binding|response to alkaloid|response to unfolded protein|regulation of angiogenesis|cellular response to toxic substance|cellular response to radiation|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|proteolysis|mitochondrion|cellular response to starvation|cellular response to oxygen levels|cellular protein localization|response to antibiotic|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular amide metabolic process|regulation of vasculature development|intracellular signal transduction|response to ammonium ion|cellular protein metabolic process|regulation of phosphorus metabolic process|phosphatase activator activity|positive regulation of translational initiation|gene expression|regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|cellular response to organic substance|protein phosphatase regulator activity|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cellular response to drug|macromolecule biosynthetic process|positive regulation of programmed cell death|cellular response to nutrient levels|cellular response to topologically incorrect protein|RNA metabolic process|negative regulation of endoplasmic reticulum unfolded protein response|circulatory system development|response to nutrient levels|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|response to light stimulus|response to cocaine|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|negative regulation of PERK-mediated unfolded protein response|cellular response to unfolded protein|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular response to carbohydrate stimulus|positive regulation of transcription, DNA-templated|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|negative regulation of phosphatase activity|intrinsic apoptotic signaling pathway|dephosphorylation|peptide biosynthetic process|regulation of PERK-mediated unfolded protein response|cellular response to antibiotic|protein localization to organelle|positive regulation of protein modification process|positive regulation of apoptotic process|response to UV|protein processing|negative regulation of transcription, DNA-templated|cellular response to methamphetamine hydrochloride|positive regulation of phosphatase activity|RNA biosynthetic process|regulation of proteolysis|regulation of RNA biosynthetic process|positive regulation of translational initiation in response to stress|positive regulation of translation|cellular response to growth factor stimulus|phosphorylation|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|transforming growth factor beta receptor signaling pathway|PERK-mediated unfolded protein response|negative regulation of transforming growth factor beta receptor signaling pathway|cellular response to desipramine|translation|protein phosphatase binding|enzyme linked receptor protein signaling pathway|regulation of translation|regulation of translational initiation in response to stress|cellular response to light stimulus|regulation of apoptotic process|cellular response to oxygen-glucose deprivation|negative regulation of proteolysis|cellular response to cordycepin|cellular response to methyl methanesulfonate|protein phosphatase type 1 regulator activity|protein kinase binding|protein phosphatase activator activity|cellular protein modification process|cellular response to calcium ion starvation|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|regulation of phosphatase activity|cellular response to decreased oxygen levels|positive regulation of transcription from RNA polymerase I promoter|protein dephosphorylation|protein localization to endoplasmic reticulum|regulation of protein dephosphorylation|transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of protein processing|transcription from RNA polymerase I promoter|protein phosphorylation|positive regulation of protein dephosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|protein phosphatase 1 binding|regulation of phosphorylation|regulation of protein processing|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|positive regulation of protein phosphorylation|positive regulation of dephosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of dephosphorylation|regulation of transcription from RNA polymerase I promoter|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|cellular response to UV|negative regulation of phosphoprotein phosphatase activity|positive regulation of phosphorylation|regulation of dephosphorylation|protein phosphatase type 1 activator activity|negative regulation of protein dephosphorylation|positive regulation of peptidyl-serine phosphorylation|peptidyl-serine phosphorylation|positive regulation of peptidyl-serine dephosphorylation|peptidyl-serine dephosphorylation|negative regulation of peptidyl-threonine phosphorylation|regulation of peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation K14019 protein phosphatase 1 regulatory subunit 15A[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 19:48872392-48876057 3539 3166 2332 641 730 733 61.0133336753809 49.6061032853027 36.2482441754373 9.90147403836755 10.3260657839784 11.8434283010364 48.9558937120403 10.6903227077941 2.19517714952806 3.27595229126386e-20 2.63612613755771e-18 UP ENSG00000184307 ZDHHC23 zinc finger, DHHC-type containing 23 [Source:HGNC Symbol;Acc:HGNC:28654] GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0009058|GO:0031224|GO:0016740|GO:0043169|GO:0016746|GO:0008104|GO:0061024|GO:0016021|GO:0044249|GO:0019538|GO:0010256|GO:0034645|GO:0046872|GO:0043412|GO:0007009|GO:0036211|GO:0042157|GO:0072657|GO:0016747|GO:0034613|GO:0044267|GO:0009059|GO:0072659|GO:0016409|GO:0042158|GO:0046914|GO:0006464|GO:1990778|GO:0019706|GO:0006497|GO:0008270|GO:0018345 membrane|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|biosynthetic process|intrinsic component of membrane|transferase activity|cation binding|transferase activity, transferring acyl groups|protein localization|membrane organization|integral component of membrane|cellular biosynthetic process|protein metabolic process|endomembrane system organization|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|plasma membrane organization|protein modification process|lipoprotein metabolic process|protein localization to membrane|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein localization|cellular protein metabolic process|macromolecule biosynthetic process|protein localization to plasma membrane|palmitoyltransferase activity|lipoprotein biosynthetic process|transition metal ion binding|cellular protein modification process|protein localization to cell periphery|protein-cysteine S-palmitoyltransferase activity|protein lipidation|zinc ion binding|protein palmitoylation - - - - 3:113947901-113965401 69 56 114 484 712 478 0.36084930923736 0.266160647377487 0.537520159882014 2.26787718248671 3.05509202912438 2.34278687184473 0.388176705498954 2.55525202781861 -2.71868014349262 3.51730964568325e-20 2.82273554199537e-18 DOWN ENSG00000076770 MBNL3 muscleblind-like splicing regulator 3 [Source:HGNC Symbol;Acc:HGNC:20564] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0034641|GO:0046483|GO:0061061|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0048869|GO:0031323|GO:0010468|GO:0046872|GO:0003723|GO:0042692|GO:0051252|GO:0051147|GO:0010467|GO:0030154|GO:0016070|GO:0005634|GO:0051148|GO:0045445|GO:0006396|GO:0043484|GO:0045661|GO:0016071|GO:0044822|GO:0045662|GO:0006397|GO:0008380 developmental process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|cellular nitrogen compound metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|cellular developmental process|regulation of cellular metabolic process|regulation of gene expression|metal ion binding|RNA binding|muscle cell differentiation|regulation of RNA metabolic process|regulation of muscle cell differentiation|gene expression|cell differentiation|RNA metabolic process|nucleus|negative regulation of muscle cell differentiation|myoblast differentiation|RNA processing|regulation of RNA splicing|regulation of myoblast differentiation|mRNA metabolic process|poly(A) RNA binding|negative regulation of myoblast differentiation|mRNA processing|RNA splicing - - - - X:132369317-132489968 104 42 107 711 869 648 0.307679709383256 0.112926252083685 0.285407138969636 1.8846624602876 2.10937470786082 1.79667596310296 0.235337700145526 1.93023771041713 -3.03597416947109 3.85040828906871e-20 3.07700232529411e-18 DOWN ENSG00000188641 DPYD dihydropyrimidine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:3012] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0048037|GO:0009058|GO:0005622|GO:0005515|GO:0042802|GO:0006725|GO:1901360|GO:0006082|GO:0051536|GO:0034641|GO:0043168|GO:0044281|GO:0046483|GO:0043169|GO:0005737|GO:0006520|GO:0046983|GO:0006139|GO:0055086|GO:0016627|GO:0050662|GO:0000166|GO:0044249|GO:0055114|GO:0005829|GO:0051539|GO:0046872|GO:0050660|GO:0050661|GO:0009116|GO:0008652|GO:0016628|GO:0019439|GO:0019482|GO:0042803|GO:0006208|GO:0017113|GO:0006213|GO:0006206|GO:0019483|GO:0006145|GO:0006144|GO:0019752|GO:0019860|GO:0046135|GO:0019859|GO:0006212|GO:0006210|GO:0046121|GO:0046104|GO:0006214 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cofactor binding|biosynthetic process|intracellular|protein binding|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|iron-sulfur cluster binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|heterocycle metabolic process|cation binding|cytoplasm|cellular amino acid metabolic process|protein dimerization activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|oxidoreductase activity, acting on the CH-CH group of donors|coenzyme binding|nucleotide binding|cellular biosynthetic process|oxidation-reduction process|cytosol|4 iron, 4 sulfur cluster binding|metal ion binding|flavin adenine dinucleotide binding|NADP binding|nucleoside metabolic process|cellular amino acid biosynthetic process|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|aromatic compound catabolic process|beta-alanine metabolic process|protein homodimerization activity|pyrimidine nucleobase catabolic process|dihydropyrimidine dehydrogenase (NADP+) activity|pyrimidine nucleoside metabolic process|pyrimidine nucleobase metabolic process|beta-alanine biosynthetic process|purine nucleobase catabolic process|purine nucleobase metabolic process|carboxylic acid metabolic process|uracil metabolic process|pyrimidine nucleoside catabolic process|thymine metabolic process|uracil catabolic process|thymine catabolic process|deoxyribonucleoside catabolic process|thymidine metabolic process|thymidine catabolic process K00207 dihydropyrimidine dehydrogenase (NADP+)[1.3.1.2] hsa01100|hsa00240|hsa00983|hsa00410|hsa00770 Metabolic pathways - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|beta-Alanine metabolism - Homo sapiens (human)|Pantothenate and CoA biosynthesis - Homo sapiens (human) 1:97077743-97921049 14 17 27 177 162 233 0.140953051839341 0.155552883575584 0.245085970642527 1.59664933977277 1.33819732055789 2.19848464873606 0.180530635352484 1.71111043635557 -3.24461729267248 3.85475604495209e-20 3.07700232529411e-18 DOWN ENSG00000100814 CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:19437] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0009653|GO:0016043|GO:0043227|GO:0032504|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0048646|GO:0048609|GO:0007049|GO:0007131|GO:0001824|GO:0006725|GO:0048468|GO:0022402|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0001825|GO:0022607|GO:0043231|GO:0043169|GO:0048515|GO:0070192|GO:0006139|GO:0007276|GO:0007126|GO:0019787|GO:0007059|GO:0048869|GO:0019538|GO:0007281|GO:0006996|GO:0051276|GO:0007286|GO:0048232|GO:0046872|GO:0043412|GO:0004842|GO:0007129|GO:0009790|GO:0036211|GO:0007127|GO:0031981|GO:0045132|GO:0006259|GO:0005694|GO:0000228|GO:0044267|GO:0030154|GO:0005634|GO:0051026|GO:0007283|GO:0009792|GO:0061630|GO:0000793|GO:0000794|GO:0045143|GO:0006310|GO:0046914|GO:0000795|GO:0006464|GO:0043009|GO:0008270|GO:0032446|GO:0001701|GO:0016567 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|ligase activity|intracellular|protein binding|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|cell cycle|reciprocal meiotic recombination|blastocyst development|cellular aromatic compound metabolic process|cell development|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|blastocyst formation|cellular component assembly|intracellular membrane-bounded organelle|cation binding|spermatid differentiation|chromosome organization involved in meiotic cell cycle|nucleobase-containing compound metabolic process|gamete generation|meiotic nuclear division|ubiquitin-like protein transferase activity|chromosome segregation|cellular developmental process|protein metabolic process|germ cell development|organelle organization|chromosome organization|spermatid development|male gamete generation|metal ion binding|macromolecule modification|ubiquitin-protein transferase activity|synapsis|embryo development|protein modification process|meiosis I|nuclear lumen|meiotic chromosome segregation|DNA metabolic process|chromosome|nuclear chromosome|cellular protein metabolic process|cell differentiation|nucleus|chiasma assembly|spermatogenesis|embryo development ending in birth or egg hatching|ubiquitin protein ligase activity|condensed chromosome|condensed nuclear chromosome|homologous chromosome segregation|DNA recombination|transition metal ion binding|synaptonemal complex|cellular protein modification process|chordate embryonic development|zinc ion binding|protein modification by small protein conjugation|in utero embryonic development|protein ubiquitination - - - - 14:20311368-20333312 2844 2824 2376 740 657 776 28.4266773800164 25.6531841837721 21.4119985009638 6.62713409266024 5.38803054700741 7.26921378467517 25.1639533549174 6.42812614144761 1.96888844809291 4.16365029850181e-20 3.31470976030595e-18 UP ENSG00000159459 UBR1 ubiquitin protein ligase E3 component n-recognin 1 [Source:HGNC Symbol;Acc:HGNC:16808] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0048523|GO:0050794|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0023057|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0043168|GO:0043169|GO:0010243|GO:0005737|GO:0043177|GO:0009966|GO:0000502|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0019787|GO:0000151|GO:0019538|GO:0010033|GO:0005829|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0070728|GO:0044265|GO:0071417|GO:0043200|GO:0036211|GO:1990234|GO:0006508|GO:0035556|GO:0044267|GO:0031406|GO:0071310|GO:1902532|GO:1902531|GO:0044257|GO:0032006|GO:0061630|GO:0010498|GO:0031929|GO:0051603|GO:0046914|GO:0016597|GO:0043201|GO:0006464|GO:0071230|GO:0032007|GO:0019941|GO:0071233|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0071596|GO:0016567 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|negative regulation of signaling|ligase activity|intracellular|protein binding|protein complex|transferase activity|anion binding|cation binding|response to organonitrogen compound|cytoplasm|organic acid binding|regulation of signal transduction|proteasome complex|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|response to organic substance|cytosol|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|leucine binding|cellular macromolecule catabolic process|cellular response to organonitrogen compound|response to amino acid|protein modification process|transferase complex|proteolysis|intracellular signal transduction|cellular protein metabolic process|carboxylic acid binding|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of intracellular signal transduction|cellular protein catabolic process|regulation of TOR signaling|ubiquitin protein ligase activity|proteasomal protein catabolic process|TOR signaling|proteolysis involved in cellular protein catabolic process|transition metal ion binding|amino acid binding|response to leucine|cellular protein modification process|cellular response to amino acid stimulus|negative regulation of TOR signaling|modification-dependent protein catabolic process|cellular response to leucine|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the N-end rule pathway|protein ubiquitination - - - - 15:42942897-43106113 130 163 190 654 773 759 0.741892759092767 0.845410299600338 0.977611628689542 3.34406349368333 3.61948531774987 4.05947779340252 0.854971562460882 3.67434220161191 -2.10353765499751 4.67842243699937e-20 3.71461764452604e-18 DOWN ENSG00000147548 WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 [Source:HGNC Symbol;Acc:HGNC:12767] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0016570|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0019538|GO:0006996|GO:0051276|GO:0008168|GO:0034645|GO:0046872|GO:0043412|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0031981|GO:0005654|GO:0005694|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0008276|GO:0046914|GO:0016568|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0016279|GO:0042054|GO:0008270|GO:0018024 cell|cellular process|metabolic process|binding|catalytic activity|methylation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|organelle organization|chromosome organization|methyltransferase activity|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|histone methylation|protein methylation|chromatin organization|protein modification process|nuclear lumen|nucleoplasm|chromosome|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|protein methyltransferase activity|transition metal ion binding|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|protein-lysine N-methyltransferase activity|histone methyltransferase activity|zinc ion binding|histone-lysine N-methyltransferase activity K11425 histone-lysine N-methyltransferase NSD3[2.1.1.43] hsa00310 Lysine degradation - Homo sapiens (human) 8:38269697-38382272 310 361 635 1916 2293 2475 1.08690946360172 1.1503220062058 2.00733722024437 6.01901412783764 6.59635681966915 8.13272915494273 1.4148562300173 6.91603336748317 -2.28928936781061 4.91491954140705e-20 3.89204265223252e-18 DOWN ENSG00000197381 ADARB1 adenosine deaminase, RNA-specific, B1 [Source:HGNC Symbol;Acc:HGNC:226] GO:0040011|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0040013|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0048870|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0016787|GO:0019239|GO:0005622|GO:0005515|GO:0019222|GO:0016032|GO:0051726|GO:0042127|GO:0007049|GO:0045087|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0006952|GO:0048524|GO:0046483|GO:0098542|GO:0043231|GO:0043169|GO:0005737|GO:0016810|GO:0006928|GO:0009615|GO:0004000|GO:0006139|GO:0044092|GO:0051270|GO:0016477|GO:0051271|GO:0008285|GO:0051607|GO:0050790|GO:0043086|GO:2000145|GO:0019538|GO:0050792|GO:0031324|GO:0031323|GO:2000146|GO:0005730|GO:0032268|GO:0046872|GO:0003723|GO:0043412|GO:0030334|GO:0036211|GO:0032269|GO:0003726|GO:0031981|GO:0005654|GO:0030336|GO:0006796|GO:0044267|GO:1903902|GO:0051174|GO:0010467|GO:0019079|GO:0019058|GO:0051246|GO:0016070|GO:0016814|GO:0005634|GO:0006396|GO:0016310|GO:0045069|GO:0009451|GO:0003725|GO:0045070|GO:0016071|GO:0044822|GO:0033673|GO:0006464|GO:0043549|GO:0045859|GO:0016556|GO:0006469|GO:0016553|GO:0006468|GO:0003729|GO:0042325|GO:0001932|GO:0006397|GO:0042326|GO:0001933|GO:0006382|GO:0044387 locomotion|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|negative regulation of locomotion|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cell motility|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|hydrolase activity|deaminase activity|intracellular|protein binding|regulation of metabolic process|viral process|regulation of cell cycle|regulation of cell proliferation|cell cycle|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|positive regulation of viral process|heterocycle metabolic process|defense response to other organism|intracellular membrane-bounded organelle|cation binding|cytoplasm|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|movement of cell or subcellular component|response to virus|adenosine deaminase activity|nucleobase-containing compound metabolic process|negative regulation of molecular function|regulation of cellular component movement|cell migration|negative regulation of cellular component movement|negative regulation of cell proliferation|defense response to virus|regulation of catalytic activity|negative regulation of catalytic activity|regulation of cell motility|protein metabolic process|regulation of viral process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|nucleolus|regulation of cellular protein metabolic process|metal ion binding|RNA binding|macromolecule modification|regulation of cell migration|protein modification process|negative regulation of cellular protein metabolic process|double-stranded RNA adenosine deaminase activity|nuclear lumen|nucleoplasm|negative regulation of cell migration|phosphate-containing compound metabolic process|cellular protein metabolic process|positive regulation of viral life cycle|regulation of phosphorus metabolic process|gene expression|viral genome replication|viral life cycle|regulation of protein metabolic process|RNA metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|nucleus|RNA processing|phosphorylation|regulation of viral genome replication|RNA modification|double-stranded RNA binding|positive regulation of viral genome replication|mRNA metabolic process|poly(A) RNA binding|negative regulation of kinase activity|cellular protein modification process|regulation of kinase activity|regulation of protein kinase activity|mRNA modification|negative regulation of protein kinase activity|base conversion or substitution editing|protein phosphorylation|mRNA binding|regulation of phosphorylation|regulation of protein phosphorylation|mRNA processing|negative regulation of phosphorylation|negative regulation of protein phosphorylation|adenosine to inosine editing|negative regulation of protein kinase activity by regulation of protein phosphorylation - - - - 21:45073853-45226560 11 15 31 182 183 227 0.0513192403973265 0.0636024242081462 0.130397456649601 0.760778951666775 0.700499872138951 0.992531866046884 0.0817730404183579 0.817936896617537 -3.32229235675393 4.99587604684671e-20 3.94568474874502e-18 DOWN ENSG00000184178 SCFD2 sec1 family domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30676] GO:0005623|GO:0009987|GO:0006810|GO:0032940|GO:0022406|GO:0045184|GO:0008104|GO:0016192|GO:0048278|GO:0015031|GO:0006887|GO:0046903|GO:0006904 cell|cellular process|transport|secretion by cell|membrane docking|establishment of protein localization|protein localization|vesicle-mediated transport|vesicle docking|protein transport|exocytosis|secretion|vesicle docking involved in exocytosis - - - - 4:52872982-53366075 11 23 28 237 298 158 0.138575658576004 0.26333719901629 0.318026483981165 2.67511686219581 3.08021412065424 1.86544747781604 0.239979780524486 2.5402594868887 -3.40399111355056 6.70006206570574e-20 5.27766894220525e-18 DOWN ENSG00000082996 RNF13 ring finger protein 13 [Source:HGNC Symbol;Acc:HGNC:10057] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0031224|GO:0016874|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019866|GO:0043231|GO:0043169|GO:0005774|GO:0005737|GO:0005635|GO:0005783|GO:0019787|GO:0031965|GO:0010008|GO:0016021|GO:0019538|GO:0005794|GO:0005768|GO:0046872|GO:0043412|GO:0004842|GO:0005773|GO:0036211|GO:0005637|GO:0005770|GO:0044267|GO:0000139|GO:0031902|GO:0005634|GO:0061630|GO:0000323|GO:0046914|GO:0006464|GO:0005765|GO:0005764|GO:0008270|GO:0032446|GO:0016567|GO:0051865 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|ligase activity|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|organelle inner membrane|intracellular membrane-bounded organelle|cation binding|vacuolar membrane|cytoplasm|nuclear envelope|endoplasmic reticulum|ubiquitin-like protein transferase activity|nuclear membrane|endosome membrane|integral component of membrane|protein metabolic process|Golgi apparatus|endosome|metal ion binding|macromolecule modification|ubiquitin-protein transferase activity|vacuole|protein modification process|nuclear inner membrane|late endosome|cellular protein metabolic process|Golgi membrane|late endosome membrane|nucleus|ubiquitin protein ligase activity|lytic vacuole|transition metal ion binding|cellular protein modification process|lysosomal membrane|lysosome|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination|protein autoubiquitination - - - - 3:149812708-149962139 167 167 325 1108 1191 1062 1.12259509934517 1.02024231415589 1.96971391598642 6.67334527364128 6.56879498998499 6.69051374940006 1.37085044316249 6.64421800434211 -2.27702822576691 6.89744089897103e-20 5.41884738415477e-18 DOWN ENSG00000115207 GTF3C2 general transcription factor IIIC subunit 2 [Source:HGNC Symbol;Acc:HGNC:4665] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005667|GO:0006139|GO:0044249|GO:0003677|GO:0034645|GO:0044798|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0034660|GO:0006351|GO:0006383|GO:0006399|GO:0000127|GO:0009303|GO:0042791|GO:0042797|GO:0009304 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor complex|nucleobase-containing compound metabolic process|cellular biosynthetic process|DNA binding|cellular macromolecule biosynthetic process|nuclear transcription factor complex|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|ncRNA metabolic process|transcription, DNA-templated|transcription from RNA polymerase III promoter|tRNA metabolic process|transcription factor TFIIIC complex|rRNA transcription|5S class rRNA transcription from RNA polymerase III type 1 promoter|tRNA transcription from RNA polymerase III promoter|tRNA transcription - - - - 2:27325849-27357034 321 397 369 1525 1448 1427 2.10948539121785 2.37105995448239 2.18631243751642 8.97924212706379 7.80744015425567 8.78870359235147 2.22228592773889 8.52512862455698 -1.93967714995948 7.27561574901392e-20 5.7009509861171e-18 DOWN ENSG00000152894 PTPRK protein tyrosine phosphatase, receptor type, K [Source:HGNC Symbol;Acc:HGNC:9674] GO:0040011|GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0040013|GO:0042995|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0009986|GO:0044237|GO:0051641|GO:0038023|GO:0048870|GO:0005911|GO:0044297|GO:0016043|GO:0007155|GO:0071944|GO:0031252|GO:0016787|GO:0009058|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0019222|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:0008013|GO:0048468|GO:0043025|GO:0009314|GO:1901360|GO:0007275|GO:0034641|GO:0016788|GO:0005912|GO:0046483|GO:0033554|GO:0022607|GO:0005887|GO:0045786|GO:0019899|GO:0004888|GO:0071559|GO:0006928|GO:0043005|GO:0031589|GO:0050673|GO:0072372|GO:0009890|GO:0036477|GO:0006979|GO:0006139|GO:0031226|GO:0008104|GO:0007154|GO:0001750|GO:0051270|GO:0016477|GO:0007165|GO:0051271|GO:0031256|GO:0008285|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:2000146|GO:0045295|GO:0031175|GO:0010468|GO:0034645|GO:0045216|GO:0007166|GO:0030424|GO:0043412|GO:0010629|GO:0051252|GO:0030334|GO:0036211|GO:0071560|GO:0007160|GO:0034329|GO:0034599|GO:0030425|GO:0071478|GO:0070848|GO:0050678|GO:0050680|GO:0030336|GO:0034613|GO:0019900|GO:0000302|GO:0006796|GO:0044267|GO:0010467|GO:0007399|GO:0071310|GO:0009059|GO:0030154|GO:0016070|GO:0043616|GO:0009416|GO:0042578|GO:0031513|GO:0048666|GO:0030182|GO:0010837|GO:0016311|GO:0009411|GO:0045892|GO:0034332|GO:0032774|GO:2001141|GO:0071363|GO:1902679|GO:0007179|GO:0034394|GO:0007167|GO:0007044|GO:0071482|GO:0048041|GO:0016791|GO:0034614|GO:0019901|GO:0022008|GO:0006464|GO:0006351|GO:0005001|GO:0006355|GO:0010839|GO:0034333|GO:0006470|GO:1903507|GO:0048699|GO:1903506|GO:0004721|GO:0007178|GO:0034644|GO:0035335|GO:0004725 locomotion|developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of locomotion|cell projection|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cell surface|cellular metabolic process|cellular localization|signaling receptor activity|cell motility|cell-cell junction|cell body|cellular component organization|cell adhesion|cell periphery|cell leading edge|hydrolase activity|biosynthetic process|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|cilium|regulation of metabolic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|beta-catenin binding|cell development|neuronal cell body|response to radiation|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|adherens junction|heterocycle metabolic process|cellular response to stress|cellular component assembly|integral component of plasma membrane|negative regulation of cell cycle|enzyme binding|transmembrane signaling receptor activity|response to transforming growth factor beta|movement of cell or subcellular component|neuron projection|cell-substrate adhesion|epithelial cell proliferation|primary cilium|negative regulation of biosynthetic process|somatodendritic compartment|response to oxidative stress|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|protein localization|cell communication|photoreceptor outer segment|regulation of cellular component movement|cell migration|signal transduction|negative regulation of cellular component movement|leading edge membrane|negative regulation of cell proliferation|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|gamma-catenin binding|neuron projection development|regulation of gene expression|cellular macromolecule biosynthetic process|cell-cell junction organization|cell surface receptor signaling pathway|axon|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|regulation of cell migration|protein modification process|cellular response to transforming growth factor beta stimulus|cell-matrix adhesion|cell junction assembly|cellular response to oxidative stress|dendrite|cellular response to radiation|response to growth factor|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of cell migration|cellular protein localization|kinase binding|response to reactive oxygen species|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|nervous system development|cellular response to organic substance|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|keratinocyte proliferation|response to light stimulus|phosphoric ester hydrolase activity|nonmotile primary cilium|neuron development|neuron differentiation|regulation of keratinocyte proliferation|dephosphorylation|response to UV|negative regulation of transcription, DNA-templated|adherens junction organization|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|negative regulation of RNA biosynthetic process|transforming growth factor beta receptor signaling pathway|protein localization to cell surface|enzyme linked receptor protein signaling pathway|cell-substrate junction assembly|cellular response to light stimulus|focal adhesion assembly|phosphatase activity|cellular response to reactive oxygen species|protein kinase binding|neurogenesis|cellular protein modification process|transcription, DNA-templated|transmembrane receptor protein tyrosine phosphatase activity|regulation of transcription, DNA-templated|negative regulation of keratinocyte proliferation|adherens junction assembly|protein dephosphorylation|negative regulation of nucleic acid-templated transcription|generation of neurons|regulation of nucleic acid-templated transcription|phosphoprotein phosphatase activity|transmembrane receptor protein serine/threonine kinase signaling pathway|cellular response to UV|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity - - - - 6:127968779-128520674 142 214 375 1296 1420 1464 0.614952232477147 0.842260477832795 1.46419342410965 5.02870257716051 5.04556219567977 5.94187159488177 0.973802044806531 5.33871212257402 -2.45479132206236 7.54408613873787e-20 5.8958415598398e-18 DOWN ENSG00000148677 ANKRD1 ankyrin repeat domain 1 (cardiac muscle) [Source:HGNC Symbol;Acc:HGNC:15819] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0051641|GO:0023051|GO:0000989|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0030017|GO:0007507|GO:0060341|GO:0044255|GO:0045595|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:0051130|GO:0009612|GO:1901360|GO:2001022|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0002039|GO:0034641|GO:0044281|GO:0032940|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0010942|GO:0061061|GO:0045597|GO:0043231|GO:0046332|GO:0019899|GO:0005737|GO:0001076|GO:0032880|GO:0051222|GO:0071559|GO:0009887|GO:0005667|GO:0009966|GO:0048729|GO:0045184|GO:0009890|GO:0031674|GO:0042493|GO:0010646|GO:0006139|GO:0009617|GO:0008104|GO:0007154|GO:0006629|GO:0007165|GO:0008134|GO:0008092|GO:0008219|GO:0001666|GO:0051047|GO:0030030|GO:0048869|GO:0030029|GO:0009967|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0003713|GO:1902533|GO:0005730|GO:0005829|GO:0031175|GO:0003677|GO:0031344|GO:0010468|GO:0034645|GO:0051053|GO:0003714|GO:0033993|GO:0007010|GO:0072358|GO:0034097|GO:0001104|GO:0001085|GO:0010629|GO:0002237|GO:0010720|GO:0042692|GO:0051252|GO:0048738|GO:0003007|GO:0051223|GO:0015031|GO:0031346|GO:0010628|GO:0071560|GO:0071456|GO:0070201|GO:0060537|GO:0071219|GO:0050714|GO:0043517|GO:0051046|GO:0043292|GO:0031981|GO:0050769|GO:2001020|GO:0035994|GO:0009306|GO:0042826|GO:0070848|GO:0005654|GO:0006259|GO:0055001|GO:0030036|GO:0071453|GO:0070925|GO:0012501|GO:0014070|GO:0035556|GO:0010467|GO:0007399|GO:0046903|GO:0071310|GO:0031432|GO:0060415|GO:0031328|GO:0071260|GO:0035690|GO:0009059|GO:0030154|GO:0030239|GO:0070412|GO:0043068|GO:0007517|GO:0001191|GO:1902531|GO:0016070|GO:0072359|GO:0010557|GO:0032496|GO:0005634|GO:0043067|GO:0006974|GO:0051960|GO:0048644|GO:0048666|GO:0030182|GO:0055002|GO:0060538|GO:0045893|GO:0010975|GO:0030016|GO:0070555|GO:1901798|GO:0043065|GO:2000279|GO:0045892|GO:0072331|GO:0042770|GO:0032774|GO:2001141|GO:0050708|GO:0071363|GO:1902679|GO:0071407|GO:2000278|GO:0001105|GO:1901796|GO:0035914|GO:0051146|GO:0042981|GO:0071345|GO:0034612|GO:0031032|GO:0055008|GO:0014706|GO:0022008|GO:0045214|GO:0050767|GO:0071396|GO:0071897|GO:0010976|GO:0006351|GO:0006915|GO:0006355|GO:0043516|GO:0071222|GO:0036294|GO:0045666|GO:0045944|GO:0006366|GO:1903507|GO:0071347|GO:0006357|GO:0048699|GO:0007519|GO:0071356|GO:1903506|GO:0001190|GO:0000122|GO:0045664|GO:0030330 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|sarcomere|heart development|regulation of cellular localization|cellular lipid metabolic process|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|transport|positive regulation of cellular component organization|response to mechanical stimulus|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|p53 binding|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|positive regulation of cell death|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|SMAD binding|enzyme binding|cytoplasm|transcription factor activity, RNA polymerase II transcription factor binding|regulation of protein localization|positive regulation of protein transport|response to transforming growth factor beta|organ morphogenesis|transcription factor complex|regulation of signal transduction|tissue morphogenesis|establishment of protein localization|negative regulation of biosynthetic process|I band|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|protein localization|cell communication|lipid metabolic process|signal transduction|transcription factor binding|cytoskeletal protein binding|cell death|response to hypoxia|positive regulation of secretion|cell projection organization|cellular developmental process|actin filament-based process|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|positive regulation of intracellular signal transduction|nucleolus|cytosol|neuron projection development|DNA binding|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|transcription corepressor activity|response to lipid|cytoskeleton organization|cardiovascular system development|response to cytokine|RNA polymerase II transcription cofactor activity|RNA polymerase II transcription factor binding|negative regulation of gene expression|response to molecule of bacterial origin|positive regulation of cell development|muscle cell differentiation|regulation of RNA metabolic process|cardiac muscle tissue development|heart morphogenesis|regulation of protein transport|protein transport|positive regulation of cell projection organization|positive regulation of gene expression|cellular response to transforming growth factor beta stimulus|cellular response to hypoxia|regulation of establishment of protein localization|muscle tissue development|cellular response to molecule of bacterial origin|positive regulation of protein secretion|positive regulation of DNA damage response, signal transduction by p53 class mediator|regulation of secretion|contractile fiber|nuclear lumen|positive regulation of neurogenesis|regulation of response to DNA damage stimulus|response to muscle stretch|protein secretion|histone deacetylase binding|response to growth factor|nucleoplasm|DNA metabolic process|muscle cell development|actin cytoskeleton organization|cellular response to oxygen levels|organelle assembly|programmed cell death|response to organic cyclic compound|intracellular signal transduction|gene expression|nervous system development|secretion|cellular response to organic substance|titin binding|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|cellular response to mechanical stimulus|cellular response to drug|macromolecule biosynthetic process|cell differentiation|myofibril assembly|R-SMAD binding|positive regulation of programmed cell death|muscle organ development|transcriptional repressor activity, RNA polymerase II transcription factor binding|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|regulation of nervous system development|muscle organ morphogenesis|neuron development|neuron differentiation|striated muscle cell development|skeletal muscle organ development|positive regulation of transcription, DNA-templated|regulation of neuron projection development|myofibril|response to interleukin-1|positive regulation of signal transduction by p53 class mediator|positive regulation of apoptotic process|negative regulation of DNA biosynthetic process|negative regulation of transcription, DNA-templated|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of protein secretion|cellular response to growth factor stimulus|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|regulation of DNA biosynthetic process|RNA polymerase II transcription coactivator activity|regulation of signal transduction by p53 class mediator|skeletal muscle cell differentiation|striated muscle cell differentiation|regulation of apoptotic process|cellular response to cytokine stimulus|response to tumor necrosis factor|actomyosin structure organization|cardiac muscle tissue morphogenesis|striated muscle tissue development|neurogenesis|sarcomere organization|regulation of neurogenesis|cellular response to lipid|DNA biosynthetic process|positive regulation of neuron projection development|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of DNA damage response, signal transduction by p53 class mediator|cellular response to lipopolysaccharide|cellular response to decreased oxygen levels|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|cellular response to interleukin-1|regulation of transcription from RNA polymerase II promoter|generation of neurons|skeletal muscle tissue development|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|transcriptional activator activity, RNA polymerase II transcription factor binding|negative regulation of transcription from RNA polymerase II promoter|regulation of neuron differentiation|DNA damage response, signal transduction by p53 class mediator - - - - 10:90912096-90921276 349 371 348 68 84 45 12.4745694974812 12.0518542172777 11.2148364626946 2.17775125863601 2.46347587090652 1.50743361584099 11.9137533924845 2.04955358179451 2.53924638940858 8.63110192883756e-20 6.7277524016584e-18 UP ENSG00000058091 CDK14 cyclin-dependent kinase 14 [Source:HGNC Symbol;Acc:HGNC:8883] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0051726|GO:0007049|GO:0022402|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0030332|GO:0009966|GO:0010646|GO:0000307|GO:0007154|GO:0007165|GO:0000166|GO:0051301|GO:0019538|GO:0030111|GO:0005829|GO:0000308|GO:0007166|GO:0035639|GO:1903047|GO:0043412|GO:0001883|GO:0044770|GO:0036211|GO:0000278|GO:0032549|GO:1990234|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005634|GO:0016055|GO:0060828|GO:0000086|GO:0005524|GO:0044772|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:1902911|GO:0006468|GO:0060070|GO:0004674|GO:0097472|GO:0004693|GO:1902554 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|transferase activity|regulation of cell cycle|cell cycle|cell cycle process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|cyclin binding|regulation of signal transduction|regulation of cell communication|cyclin-dependent protein kinase holoenzyme complex|cell communication|signal transduction|nucleotide binding|cell division|protein metabolic process|regulation of Wnt signaling pathway|cytosol|cytoplasmic cyclin-dependent protein kinase holoenzyme complex|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|purine nucleoside binding|cell cycle phase transition|protein modification process|mitotic cell cycle|ribonucleoside binding|transferase complex|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|Wnt signaling pathway|regulation of canonical Wnt signaling pathway|G2/M transition of mitotic cell cycle|ATP binding|mitotic cell cycle phase transition|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein kinase complex|protein phosphorylation|canonical Wnt signaling pathway|protein serine/threonine kinase activity|cyclin-dependent protein kinase activity|cyclin-dependent protein serine/threonine kinase activity|serine/threonine protein kinase complex K08821 cyclin-dependent kinase 14[2.7.11.22] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 7:90466424-91210590 21 35 87 465 554 648 0.0974996201978743 0.147682199883519 0.364171938358475 1.93430707730976 2.11033979255291 2.8195407113279 0.203117919479956 2.28806252706352 -3.49373705004526 9.87241240436751e-20 7.67528645624968e-18 DOWN ENSG00000112584 FAM120B family with sequence similarity 120B [Source:HGNC Symbol;Acc:HGNC:21109] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 developmental process|cell|cellular process|metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 6:170290703-170407065 46 53 102 423 455 501 0.393836409769231 0.412401045128123 0.787359121109122 3.24487665681632 3.19624506977602 4.0200095524704 0.531198858668825 3.48704375968758 -2.71468051689555 9.99082994699013e-20 7.74717499318035e-18 DOWN ENSG00000152348 ATG10 autophagy related 10 [Source:HGNC Symbol;Acc:HGNC:20315] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0050794|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0009607|GO:0009893|GO:0009058|GO:0016874|GO:0005622|GO:0016740|GO:0019222|GO:0006810|GO:0031325|GO:0033554|GO:0005737|GO:0045184|GO:0034263|GO:0008104|GO:0007154|GO:0007165|GO:0016236|GO:0019787|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0005829|GO:0034645|GO:0043412|GO:0006984|GO:0015031|GO:0036211|GO:0042157|GO:0051247|GO:0019777|GO:0032270|GO:0044267|GO:0051246|GO:0006983|GO:0009059|GO:0034976|GO:0031401|GO:0042158|GO:0006464|GO:0006497|GO:0032446 signaling|cell|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|regulation of cellular process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|response to biotic stimulus|positive regulation of metabolic process|biosynthetic process|ligase activity|intracellular|transferase activity|regulation of metabolic process|transport|positive regulation of cellular metabolic process|cellular response to stress|cytoplasm|establishment of protein localization|autophagy in response to ER overload|protein localization|cell communication|signal transduction|macroautophagy|ubiquitin-like protein transferase activity|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|cellular macromolecule biosynthetic process|macromolecule modification|ER-nucleus signaling pathway|protein transport|protein modification process|lipoprotein metabolic process|positive regulation of protein metabolic process|Atg12 transferase activity|positive regulation of cellular protein metabolic process|cellular protein metabolic process|regulation of protein metabolic process|ER overload response|macromolecule biosynthetic process|response to endoplasmic reticulum stress|positive regulation of protein modification process|lipoprotein biosynthetic process|cellular protein modification process|protein lipidation|protein modification by small protein conjugation K17888 ubiquitin-like-conjugating enzyme ATG10, animal type[-] hsa04140 Regulation of autophagy - Homo sapiens (human) 5:81972025-82276857 18 14 25 151 170 155 0.16072587654833 0.113610480826429 0.20126457027783 1.20804797948319 1.24545642904163 1.29709162270305 0.158533642550863 1.25019867707596 -2.97929644757889 1.0830369791093e-19 8.37642123687278e-18 DOWN ENSG00000071051 NCK2 NCK adaptor protein 2 [Source:HGNC Symbol;Acc:HGNC:7665] GO:0040011|GO:0032502|GO:0002376|GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0060076|GO:0043229|GO:0006807|GO:0006950|GO:0044089|GO:0071704|GO:0032947|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0005085|GO:0048856|GO:0031090|GO:0019222|GO:0035591|GO:0008284|GO:0042127|GO:0016337|GO:0006935|GO:0006725|GO:0070661|GO:0048468|GO:0050867|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0030159|GO:0007275|GO:0070489|GO:0032535|GO:0016358|GO:0034641|GO:0030155|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0010942|GO:0098609|GO:0043231|GO:0006413|GO:1903573|GO:0005737|GO:0032970|GO:0012506|GO:0006928|GO:0032403|GO:0097110|GO:0002696|GO:0001775|GO:0009966|GO:0009890|GO:0030674|GO:0097481|GO:0014069|GO:0008037|GO:0010646|GO:0006139|GO:0005086|GO:0043085|GO:0046649|GO:0050865|GO:0007154|GO:0060996|GO:0016477|GO:0007165|GO:0005783|GO:0009968|GO:0045785|GO:0008092|GO:0008219|GO:0008285|GO:0050790|GO:0010998|GO:0030030|GO:0048869|GO:0030029|GO:0009967|GO:0044249|GO:0010469|GO:0019538|GO:0031334|GO:0043254|GO:0010033|GO:0031324|GO:0031323|GO:0005794|GO:0006996|GO:0016192|GO:1902533|GO:0051249|GO:2001235|GO:0036492|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0001771|GO:0010468|GO:0034645|GO:0043555|GO:0032943|GO:0005802|GO:0006518|GO:0007166|GO:0032956|GO:0030968|GO:0043412|GO:0007010|GO:0007176|GO:0051345|GO:0010629|GO:0043620|GO:0006984|GO:0051252|GO:0006446|GO:0034109|GO:0000904|GO:1900101|GO:0010628|GO:1903912|GO:0009988|GO:0036211|GO:0032269|GO:1902235|GO:0007172|GO:0051251|GO:0022407|GO:0006986|GO:1901184|GO:0030031|GO:0007159|GO:0051247|GO:0006461|GO:0030036|GO:0032270|GO:0042110|GO:0012501|GO:0097581|GO:0006796|GO:0043603|GO:0035556|GO:0032273|GO:0008093|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0031328|GO:0051246|GO:0046651|GO:0009059|GO:0030154|GO:0022409|GO:0030832|GO:0048858|GO:0043068|GO:0035967|GO:1902531|GO:0016070|GO:1900102|GO:0005070|GO:0034976|GO:0010557|GO:0043067|GO:0097190|GO:0010638|GO:0048666|GO:0030182|GO:1903898|GO:0034620|GO:0070059|GO:0007411|GO:0042098|GO:0045893|GO:1990441|GO:0097193|GO:0043043|GO:1903897|GO:2001242|GO:0030032|GO:0050863|GO:0034622|GO:0043065|GO:2001244|GO:0030838|GO:0045892|GO:0042058|GO:0032774|GO:2001141|GO:0045727|GO:0043623|GO:0043087|GO:0016310|GO:0010608|GO:1902237|GO:0034112|GO:1902679|GO:0070486|GO:0036499|GO:0008064|GO:0061564|GO:0006412|GO:0043547|GO:0051493|GO:0007167|GO:0006417|GO:0043558|GO:0042981|GO:0022008|GO:0048667|GO:0006464|GO:0050870|GO:0007015|GO:0051495|GO:0048812|GO:0050671|GO:0030833|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0043618|GO:1903039|GO:0032946|GO:0051258|GO:0045944|GO:0006366|GO:0097201|GO:0045859|GO:1903507|GO:0006357|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0036493|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:0042129|GO:0001933|GO:0000122|GO:0071593|GO:0042102|GO:0007169|GO:0008154|GO:0048010|GO:0033137|GO:0050730|GO:0061097|GO:0048013|GO:0018105|GO:0033135|GO:0030041|GO:0038127|GO:0018108|GO:0007173 locomotion|developmental process|immune system process|synapse|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|binding, bridging|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|protein complex scaffold|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|anatomical structure development|organelle membrane|regulation of metabolic process|signaling adaptor activity|positive regulation of cell proliferation|regulation of cell proliferation|single organismal cell-cell adhesion|chemotaxis|cellular aromatic compound metabolic process|leukocyte proliferation|cell development|positive regulation of cell activation|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|receptor signaling complex scaffold activity|multicellular organism development|T cell aggregation|regulation of cellular component size|dendrite development|cellular nitrogen compound metabolic process|regulation of cell adhesion|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|positive regulation of cell death|cell-cell adhesion|intracellular membrane-bounded organelle|translational initiation|negative regulation of response to endoplasmic reticulum stress|cytoplasm|regulation of actin filament-based process|vesicle membrane|movement of cell or subcellular component|protein complex binding|scaffold protein binding|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|negative regulation of biosynthetic process|protein binding, bridging|neuronal postsynaptic density|postsynaptic density|cell recognition|regulation of cell communication|nucleobase-containing compound metabolic process|ARF guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|lymphocyte activation|regulation of cell activation|cell communication|dendritic spine development|cell migration|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|positive regulation of cell adhesion|cytoskeletal protein binding|cell death|negative regulation of cell proliferation|regulation of catalytic activity|regulation of translational initiation by eIF2 alpha phosphorylation|cell projection organization|cellular developmental process|actin filament-based process|positive regulation of signal transduction|cellular biosynthetic process|regulation of receptor activity|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|positive regulation of apoptotic signaling pathway|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|immunological synapse formation|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of translation in response to stress|mononuclear cell proliferation|trans-Golgi network|peptide metabolic process|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|endoplasmic reticulum unfolded protein response|macromolecule modification|cytoskeleton organization|regulation of epidermal growth factor-activated receptor activity|positive regulation of hydrolase activity|negative regulation of gene expression|regulation of DNA-templated transcription in response to stress|ER-nucleus signaling pathway|regulation of RNA metabolic process|regulation of translational initiation|homotypic cell-cell adhesion|cell morphogenesis involved in differentiation|regulation of endoplasmic reticulum unfolded protein response|positive regulation of gene expression|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|cell-cell recognition|protein modification process|negative regulation of cellular protein metabolic process|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|signal complex assembly|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|response to unfolded protein|regulation of ERBB signaling pathway|cell projection assembly|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|protein complex assembly|actin cytoskeleton organization|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|lamellipodium organization|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|positive regulation of protein polymerization|cytoskeletal adaptor activity|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|regulation of actin filament length|cell projection morphogenesis|positive regulation of programmed cell death|cellular response to topologically incorrect protein|regulation of intracellular signal transduction|RNA metabolic process|negative regulation of endoplasmic reticulum unfolded protein response|SH3/SH2 adaptor activity|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|apoptotic signaling pathway|positive regulation of organelle organization|neuron development|neuron differentiation|negative regulation of PERK-mediated unfolded protein response|cellular response to unfolded protein|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|axon guidance|T cell proliferation|positive regulation of transcription, DNA-templated|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|intrinsic apoptotic signaling pathway|peptide biosynthetic process|regulation of PERK-mediated unfolded protein response|regulation of intrinsic apoptotic signaling pathway|lamellipodium assembly|regulation of T cell activation|cellular macromolecular complex assembly|positive regulation of apoptotic process|positive regulation of intrinsic apoptotic signaling pathway|positive regulation of actin filament polymerization|negative regulation of transcription, DNA-templated|regulation of epidermal growth factor receptor signaling pathway|RNA biosynthetic process|regulation of RNA biosynthetic process|positive regulation of translation|cellular protein complex assembly|regulation of GTPase activity|phosphorylation|posttranscriptional regulation of gene expression|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of homotypic cell-cell adhesion|negative regulation of RNA biosynthetic process|leukocyte aggregation|PERK-mediated unfolded protein response|regulation of actin polymerization or depolymerization|axon development|translation|positive regulation of GTPase activity|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|regulation of translation|regulation of translational initiation in response to stress|regulation of apoptotic process|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|positive regulation of T cell activation|actin filament organization|positive regulation of cytoskeleton organization|neuron projection morphogenesis|positive regulation of lymphocyte proliferation|regulation of actin filament polymerization|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|protein polymerization|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter in response to stress|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|positive regulation of translation in response to endoplasmic reticulum stress|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|regulation of T cell proliferation|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|lymphocyte aggregation|positive regulation of T cell proliferation|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|vascular endothelial growth factor receptor signaling pathway|negative regulation of peptidyl-serine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|ephrin receptor signaling pathway|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|actin filament polymerization|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|epidermal growth factor receptor signaling pathway K19862 NCK adaptor protein 2[-] hsa04360|hsa04660|hsa04012|hsa05130 Axon guidance - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human) 2:105744897-105894274 98 103 120 461 573 648 1.3141650187042 1.25528389361176 1.45083715536387 5.53887757714959 6.3044309824924 8.14379569247239 1.34009535589328 6.66236808403813 -2.31369940174306 1.11239318642496e-19 8.58123674096398e-18 DOWN ENSG00000213066 FGFR1OP FGFR1 oncogene partner [Source:HGNC Symbol;Acc:HGNC:17012] GO:0040011|GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0016049|GO:0071704|GO:0044237|GO:0048870|GO:0040017|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0030234|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0042802|GO:0008284|GO:0051272|GO:0042127|GO:0007049|GO:0004857|GO:0022402|GO:0030307|GO:0016772|GO:0051128|GO:2000147|GO:0043231|GO:0019899|GO:0005737|GO:0006928|GO:0046983|GO:0044092|GO:0051270|GO:0016477|GO:0050790|GO:0019207|GO:0043086|GO:2000145|GO:0007017|GO:0019538|GO:0001558|GO:0031324|GO:0031323|GO:0006996|GO:0032268|GO:0005829|GO:0005813|GO:0019210|GO:1903047|GO:0043412|GO:0007010|GO:0019887|GO:0005815|GO:0044770|GO:0030334|GO:0036211|GO:0032269|GO:0000278|GO:0048471|GO:0016301|GO:0019900|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0030335|GO:0000226|GO:0016773|GO:0005856|GO:0005634|GO:0042803|GO:0034453|GO:0000086|GO:0044772|GO:0016310|GO:0015630|GO:0004860|GO:0004672|GO:0033673|GO:0019901|GO:0006464|GO:0043549|GO:0045859|GO:0006469|GO:0006468|GO:0042325|GO:0004713|GO:0001932|GO:0018193|GO:0042326|GO:0030292|GO:0001933|GO:0050730|GO:0061097|GO:0061099|GO:0050732|GO:0018108 locomotion|growth|cell|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|cell growth|organic substance metabolic process|cellular metabolic process|cell motility|positive regulation of locomotion|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|enzyme regulator activity|intracellular|protein binding|transferase activity|regulation of metabolic process|identical protein binding|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|cell cycle|enzyme inhibitor activity|cell cycle process|positive regulation of cell growth|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|positive regulation of cell motility|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|movement of cell or subcellular component|protein dimerization activity|negative regulation of molecular function|regulation of cellular component movement|cell migration|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|regulation of cell motility|microtubule-based process|protein metabolic process|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cytosol|centrosome|kinase inhibitor activity|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|protein kinase regulator activity|microtubule organizing center|cell cycle phase transition|regulation of cell migration|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|perinuclear region of cytoplasm|kinase activity|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|positive regulation of cell migration|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|protein homodimerization activity|microtubule anchoring|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|phosphorylation|microtubule cytoskeleton|protein kinase inhibitor activity|protein kinase activity|negative regulation of kinase activity|protein kinase binding|cellular protein modification process|regulation of kinase activity|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|protein tyrosine kinase activity|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|protein tyrosine kinase inhibitor activity|negative regulation of protein phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|negative regulation of protein tyrosine kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation - - - - 6:166999182-167052713 57 70 100 450 428 398 0.212926633946855 0.237648455087392 0.336801420731088 1.50614817806796 1.31180338807299 1.39337985570346 0.262458836588445 1.4037771406148 -2.41915083912954 1.1282654782512e-19 8.68124680095656e-18 DOWN ENSG00000125257 ABCC4 ATP binding cassette subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:55] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0016491|GO:0043229|GO:0006950|GO:0043167|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0050817|GO:0016323|GO:0006810|GO:0043168|GO:0032940|GO:0001882|GO:0031982|GO:0016817|GO:0016614|GO:0030141|GO:0043231|GO:0005737|GO:0009611|GO:0012506|GO:0001775|GO:0055085|GO:0030667|GO:0000166|GO:0016021|GO:0050878|GO:0055114|GO:0016192|GO:0016820|GO:0030168|GO:0035639|GO:0031410|GO:0007596|GO:0001883|GO:0042827|GO:0016023|GO:0006887|GO:0016818|GO:0042060|GO:0032549|GO:0016616|GO:0007599|GO:0031988|GO:0030659|GO:0046903|GO:0017076|GO:0031088|GO:0045055|GO:0005524|GO:0030554|GO:0016404|GO:0042626|GO:0016462|GO:0017111|GO:0002576|GO:0016887|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|oxidoreductase activity|intracellular organelle|response to stress|ion binding|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|organelle membrane|coagulation|basolateral plasma membrane|transport|anion binding|secretion by cell|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|oxidoreductase activity, acting on CH-OH group of donors|secretory granule|intracellular membrane-bounded organelle|cytoplasm|response to wounding|vesicle membrane|cell activation|transmembrane transport|secretory granule membrane|nucleotide binding|integral component of membrane|regulation of body fluid levels|oxidation-reduction process|vesicle-mediated transport|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|platelet activation|purine ribonucleoside triphosphate binding|cytoplasmic vesicle|blood coagulation|purine nucleoside binding|platelet dense granule|cytoplasmic, membrane-bounded vesicle|exocytosis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|wound healing|ribonucleoside binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|hemostasis|membrane-bounded vesicle|cytoplasmic vesicle membrane|secretion|purine nucleotide binding|platelet dense granule membrane|regulated exocytosis|ATP binding|adenyl nucleotide binding|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|nucleoside-triphosphatase activity|platelet degranulation|ATPase activity|ATPase activity, coupled|ATPase activity, coupled to movement of substances K05673 ATP-binding cassette, subfamily C (CFTR/MRP), member 4[-] hsa04024|hsa04976|hsa02010 cAMP signaling pathway - Homo sapiens (human)|Bile secretion - Homo sapiens (human)|ABC transporters - Homo sapiens (human) 13:95019829-95301446 145 212 269 1015 898 1259 1.11864582665511 1.48641160876461 1.8710723222616 7.01596874641005 5.68418425223158 9.10287495106958 1.49204325256044 7.26767598323707 -2.28420474272901 1.13620498320035e-19 8.71986209986205e-18 DOWN ENSG00000090889 KIF4A kinesin family member 4A [Source:HGNC Symbol;Acc:HGNC:13339] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0030496|GO:0097159|GO:0044877|GO:0019882|GO:0043229|GO:0006950|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0007049|GO:0050817|GO:0006935|GO:0048468|GO:0019884|GO:0006810|GO:0022402|GO:0007275|GO:0003676|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0022607|GO:0043231|GO:0005737|GO:0009611|GO:0006928|GO:0032403|GO:0005875|GO:0010970|GO:0051649|GO:0008092|GO:0002504|GO:0048002|GO:0000166|GO:0030030|GO:0051301|GO:0048869|GO:0007017|GO:0050878|GO:0006996|GO:0015631|GO:0000902|GO:0005829|GO:0031175|GO:0003677|GO:0005871|GO:0035639|GO:1903047|GO:0007010|GO:0007596|GO:0001883|GO:0000904|GO:0008017|GO:0016818|GO:0000278|GO:0042060|GO:0046907|GO:0051255|GO:0032549|GO:0008088|GO:0031981|GO:0007599|GO:0007018|GO:0005654|GO:0016363|GO:0005876|GO:0007051|GO:0005694|GO:0006461|GO:0070925|GO:0007067|GO:0032990|GO:0007399|GO:0097485|GO:0017076|GO:0030154|GO:0034399|GO:0048858|GO:0000226|GO:0005856|GO:0000910|GO:0005634|GO:0005819|GO:0002495|GO:0048666|GO:0030182|GO:0007411|GO:0051256|GO:0051225|GO:0005524|GO:0008089|GO:0030554|GO:0061564|GO:0007052|GO:0019886|GO:0015630|GO:0000022|GO:0022008|GO:0048667|GO:0030705|GO:0048812|GO:0090307|GO:0016462|GO:0000281|GO:0007409|GO:0048699|GO:0017111|GO:0016887|GO:0003774|GO:0003777 locomotion|developmental process|macromolecular complex|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|midbody|organic cyclic compound binding|macromolecular complex binding|antigen processing and presentation|intracellular organelle|response to stress|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|hydrolase activity|intracellular|protein binding|protein complex|anatomical structure development|cell cycle|coagulation|chemotaxis|cell development|antigen processing and presentation of exogenous antigen|transport|cell cycle process|multicellular organism development|nucleic acid binding|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|response to wounding|movement of cell or subcellular component|protein complex binding|microtubule associated complex|establishment of localization by movement along microtubule|establishment of localization in cell|cytoskeletal protein binding|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|antigen processing and presentation of peptide antigen|nucleotide binding|cell projection organization|cell division|cellular developmental process|microtubule-based process|regulation of body fluid levels|organelle organization|tubulin binding|cell morphogenesis|cytosol|neuron projection development|DNA binding|kinesin complex|purine ribonucleoside triphosphate binding|mitotic cell cycle process|cytoskeleton organization|blood coagulation|purine nucleoside binding|cell morphogenesis involved in differentiation|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|wound healing|intracellular transport|spindle midzone assembly|ribonucleoside binding|axo-dendritic transport|nuclear lumen|hemostasis|microtubule-based movement|nucleoplasm|nuclear matrix|spindle microtubule|spindle organization|chromosome|protein complex assembly|organelle assembly|mitotic nuclear division|cell part morphogenesis|nervous system development|neuron projection guidance|purine nucleotide binding|cell differentiation|nuclear periphery|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|cytokinesis|nucleus|spindle|antigen processing and presentation of peptide antigen via MHC class II|neuron development|neuron differentiation|axon guidance|mitotic spindle midzone assembly|spindle assembly|ATP binding|anterograde axonal transport|adenyl nucleotide binding|axon development|mitotic spindle organization|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule cytoskeleton|mitotic spindle elongation|neurogenesis|cell morphogenesis involved in neuron differentiation|cytoskeleton-dependent intracellular transport|neuron projection morphogenesis|mitotic spindle assembly|pyrophosphatase activity|mitotic cytokinesis|axonogenesis|generation of neurons|nucleoside-triphosphatase activity|ATPase activity|motor activity|microtubule motor activity - - - - X:70290090-70420832 336 369 383 1482 1591 1275 5.19851347041004 5.18854875149486 5.34259838262921 20.5440248842823 20.1965712688838 18.4875269872925 5.24322020151137 19.7427077134862 -1.91279482742 1.1463935476798e-19 8.77549563395711e-18 DOWN ENSG00000197818 SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 [Source:HGNC Symbol;Acc:HGNC:20728] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0042592|GO:0019725|GO:0022891|GO:0055085|GO:0071804|GO:0016021|GO:0005794|GO:0048878|GO:0006811|GO:0055082|GO:0015075|GO:0000139|GO:0071805|GO:0034220|GO:0098655|GO:0015992|GO:0015297|GO:0006812|GO:0050801|GO:0006873|GO:0008324|GO:1902600|GO:0022890|GO:0015491|GO:0030001|GO:0030003|GO:0015672|GO:0005451|GO:0006813|GO:0015386|GO:0035725|GO:0006814|GO:0015299|GO:0015077|GO:0046873|GO:0015079|GO:0015385|GO:0015078|GO:0006885|GO:0030641|GO:0015081|GO:0051453 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|transmembrane transport|cellular potassium ion transport|integral component of membrane|Golgi apparatus|chemical homeostasis|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|Golgi membrane|potassium ion transmembrane transport|ion transmembrane transport|cation transmembrane transport|proton transport|antiporter activity|cation transport|ion homeostasis|cellular ion homeostasis|cation transmembrane transporter activity|hydrogen ion transmembrane transport|inorganic cation transmembrane transporter activity|cation:cation antiporter activity|metal ion transport|cellular cation homeostasis|monovalent inorganic cation transport|monovalent cation:proton antiporter activity|potassium ion transport|potassium:proton antiporter activity|sodium ion transmembrane transport|sodium ion transport|solute:proton antiporter activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium ion transmembrane transporter activity|sodium:proton antiporter activity|hydrogen ion transmembrane transporter activity|regulation of pH|regulation of cellular pH|sodium ion transmembrane transporter activity|regulation of intracellular pH - - - - 20:49812713-49892242 98 112 118 490 541 533 0.585195042517699 0.607815113359428 0.63528700747518 2.62160998530781 2.6505709816675 2.9828418741853 0.609432387784102 2.75167428038687 -2.17477162825649 1.22260223393317e-19 9.33492764497208e-18 DOWN ENSG00000113391 FAM172A family with sequence similarity 172 member A [Source:HGNC Symbol;Acc:HGNC:25365] GO:0005623|GO:0005576|GO:0043229|GO:0043227|GO:0005622|GO:0012505|GO:0043231|GO:0005737|GO:0005783 cell|extracellular region|intracellular organelle|membrane-bounded organelle|intracellular|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum - - - - 5:93618069-94111699 43 30 67 342 347 326 0.416958034152617 0.264375471195625 0.585747684886799 2.97128804540164 2.76068838511725 2.96255416444844 0.422360396745014 2.89817686498911 -2.77859917022077 1.31763403828013e-19 1.00348588211263e-17 DOWN ENSG00000162413 KLHL21 kelch like family member 21 [Source:HGNC Symbol;Acc:HGNC:29041] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0051726|GO:0007049|GO:0022402|GO:0051302|GO:0005874|GO:0005737|GO:0008104|GO:0019787|GO:0051301|GO:0000151|GO:0019538|GO:0006996|GO:0005813|GO:1903047|GO:0043412|GO:0030163|GO:0004842|GO:0031461|GO:0005815|GO:0044265|GO:0036211|GO:0000278|GO:0032465|GO:1990234|GO:0010564|GO:0006508|GO:0005876|GO:0034613|GO:0044267|GO:0007067|GO:0031503|GO:0005856|GO:0000910|GO:0000922|GO:0005819|GO:0044257|GO:0033365|GO:0005827|GO:0034629|GO:0051603|GO:0015630|GO:0006464|GO:0031463|GO:0019941|GO:0044380|GO:0035853|GO:0032446|GO:0006511|GO:0042787|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|intracellular|protein binding|protein complex|transferase activity|regulation of cell cycle|cell cycle|cell cycle process|regulation of cell division|microtubule|cytoplasm|protein localization|ubiquitin-like protein transferase activity|cell division|ubiquitin ligase complex|protein metabolic process|organelle organization|centrosome|mitotic cell cycle process|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|microtubule organizing center|cellular macromolecule catabolic process|protein modification process|mitotic cell cycle|regulation of cytokinesis|transferase complex|regulation of cell cycle process|proteolysis|spindle microtubule|cellular protein localization|cellular protein metabolic process|mitotic nuclear division|protein complex localization|cytoskeleton|cytokinesis|spindle pole|spindle|cellular protein catabolic process|protein localization to organelle|polar microtubule|cellular protein complex localization|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|cellular protein modification process|Cul3-RING ubiquitin ligase complex|modification-dependent protein catabolic process|protein localization to cytoskeleton|chromosome passenger complex localization to spindle midzone|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - 1:6590724-6614607 3183 3348 2536 737 948 632 16.5787079908998 15.8481843463149 11.909059326808 3.43937246705265 4.05126044608294 3.08503643582932 14.7786505546742 3.52522311632164 2.06772806664657 1.32339090489274e-19 1.00530565075491e-17 UP ENSG00000134324 LPIN1 lipin 1 [Source:HGNC Symbol;Acc:HGNC:13345] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0000988|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0019867|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005789|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0007049|GO:0044255|GO:0003712|GO:0006725|GO:0022402|GO:1901360|GO:0006082|GO:0007275|GO:0048513|GO:0034641|GO:0016788|GO:0044281|GO:0019637|GO:0031325|GO:0046483|GO:0043231|GO:0010243|GO:0005737|GO:0005635|GO:0031966|GO:0006139|GO:0061024|GO:0006629|GO:0005783|GO:0009725|GO:0031965|GO:0044249|GO:0010033|GO:0031323|GO:0010256|GO:0006996|GO:0003713|GO:0005740|GO:0005829|GO:0006998|GO:0010468|GO:0008654|GO:0034645|GO:0046486|GO:1903047|GO:0016042|GO:0005741|GO:0051252|GO:0006066|GO:0044242|GO:0009308|GO:0006631|GO:0031100|GO:1901652|GO:0071417|GO:0010628|GO:0000278|GO:0046470|GO:0006638|GO:0031981|GO:0043434|GO:0005654|GO:0005739|GO:0006796|GO:0010467|GO:0008610|GO:0071310|GO:0006997|GO:0031328|GO:0009059|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0042578|GO:0006644|GO:0045893|GO:0016311|GO:0007077|GO:0006656|GO:1901653|GO:0046474|GO:0032774|GO:2001141|GO:0046395|GO:0051081|GO:0006576|GO:0071375|GO:0016791|GO:0019752|GO:0032868|GO:0006639|GO:0009062|GO:0006351|GO:0006650|GO:0006355|GO:0045944|GO:0008195|GO:0006366|GO:0006357|GO:1903506|GO:0032869|GO:0006646|GO:0032787|GO:0046337|GO:0006641|GO:0019432|GO:0006642 developmental process|cell|membrane|cellular process|metabolic process|response to stimulus|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|outer membrane|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|endoplasmic reticulum membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|cell cycle|cellular lipid metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|nuclear envelope|mitochondrial membrane|nucleobase-containing compound metabolic process|membrane organization|lipid metabolic process|endoplasmic reticulum|response to hormone|nuclear membrane|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|organelle organization|transcription coactivator activity|mitochondrial envelope|cytosol|nuclear envelope organization|regulation of gene expression|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|glycerolipid metabolic process|mitotic cell cycle process|lipid catabolic process|mitochondrial outer membrane|regulation of RNA metabolic process|alcohol metabolic process|cellular lipid catabolic process|amine metabolic process|fatty acid metabolic process|organ regeneration|response to peptide|cellular response to organonitrogen compound|positive regulation of gene expression|mitotic cell cycle|phosphatidylcholine metabolic process|neutral lipid metabolic process|nuclear lumen|response to peptide hormone|nucleoplasm|mitochondrion|phosphate-containing compound metabolic process|gene expression|lipid biosynthetic process|cellular response to organic substance|nucleus organization|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|phosphoric ester hydrolase activity|phospholipid metabolic process|positive regulation of transcription, DNA-templated|dephosphorylation|mitotic nuclear envelope disassembly|phosphatidylcholine biosynthetic process|cellular response to peptide|glycerophospholipid biosynthetic process|RNA biosynthetic process|regulation of RNA biosynthetic process|carboxylic acid catabolic process|nuclear envelope disassembly|cellular biogenic amine metabolic process|cellular response to peptide hormone stimulus|phosphatase activity|carboxylic acid metabolic process|response to insulin|acylglycerol metabolic process|fatty acid catabolic process|transcription, DNA-templated|glycerophospholipid metabolic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|phosphatidate phosphatase activity|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|cellular response to insulin stimulus|phosphatidylethanolamine biosynthetic process|monocarboxylic acid metabolic process|phosphatidylethanolamine metabolic process|triglyceride metabolic process|triglyceride biosynthetic process|triglyceride mobilization K15728 phosphatidate phosphatase LPIN[3.1.3.4] hsa01100|hsa00564|hsa00561 Metabolic pathways - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human) 2:11677595-11827409 74 87 156 551 653 665 0.240901500389332 0.257399130449488 0.45787238796412 1.60714545535658 1.74416205956017 2.02888266829878 0.31872433960098 1.79339672773851 -2.49231356966346 1.58052836962315e-19 1.19759121692207e-17 DOWN ENSG00000156110 ADK adenosine kinase [Source:HGNC Symbol;Acc:HGNC:257] GO:0002376|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0043167|GO:0044237|GO:0007155|GO:0043227|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0016740|GO:0019222|GO:0008284|GO:0042127|GO:0016337|GO:0006725|GO:0070661|GO:0050867|GO:1901360|GO:0003676|GO:0070489|GO:0034641|GO:0043168|GO:0044281|GO:0030155|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0032922|GO:0098609|GO:0043231|GO:0043169|GO:0005737|GO:0003012|GO:0002696|GO:0001775|GO:0050673|GO:0006139|GO:0055086|GO:0046649|GO:0050865|GO:0045785|GO:0000166|GO:0044249|GO:0051249|GO:0005829|GO:0009262|GO:0010468|GO:0032943|GO:0010613|GO:0046872|GO:0003723|GO:0035639|GO:0019693|GO:0001883|GO:0034109|GO:0090257|GO:0009116|GO:0032549|GO:0051251|GO:0022407|GO:0031981|GO:0007159|GO:0005654|GO:0016301|GO:0044342|GO:0042110|GO:0006796|GO:1901137|GO:0010611|GO:0014896|GO:0010467|GO:0017076|GO:0046651|GO:0022409|GO:0016773|GO:0005634|GO:0004001|GO:0043101|GO:0009142|GO:0042098|GO:0050863|GO:0009124|GO:0009259|GO:0009117|GO:0005524|GO:0046390|GO:0030554|GO:0016310|GO:0034112|GO:0019205|GO:0070486|GO:0009263|GO:0006163|GO:0006144|GO:0044822|GO:0050870|GO:0009165|GO:0050671|GO:0042278|GO:1903039|GO:0032946|GO:0003300|GO:0019206|GO:0006164|GO:0009200|GO:0006166|GO:0032261|GO:0042129|GO:0071593|GO:0009156|GO:0042102|GO:0009152|GO:0046033|GO:0044209|GO:0009168|GO:0046085|GO:0046060|GO:0006175|GO:0006167 immune system process|cell|rhythmic process|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|ion binding|cellular metabolic process|cell adhesion|membrane-bounded organelle|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|transferase activity|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|single organismal cell-cell adhesion|cellular aromatic compound metabolic process|leukocyte proliferation|positive regulation of cell activation|organic cyclic compound metabolic process|nucleic acid binding|T cell aggregation|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|circadian regulation of gene expression|cell-cell adhesion|intracellular membrane-bounded organelle|cation binding|cytoplasm|muscle system process|positive regulation of leukocyte activation|cell activation|epithelial cell proliferation|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|lymphocyte activation|regulation of cell activation|positive regulation of cell adhesion|nucleotide binding|cellular biosynthetic process|regulation of lymphocyte activation|cytosol|deoxyribonucleotide metabolic process|regulation of gene expression|mononuclear cell proliferation|positive regulation of cardiac muscle hypertrophy|metal ion binding|RNA binding|purine ribonucleoside triphosphate binding|ribose phosphate metabolic process|purine nucleoside binding|homotypic cell-cell adhesion|regulation of muscle system process|nucleoside metabolic process|ribonucleoside binding|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|nuclear lumen|leukocyte cell-cell adhesion|nucleoplasm|kinase activity|type B pancreatic cell proliferation|T cell activation|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of cardiac muscle hypertrophy|muscle hypertrophy|gene expression|purine nucleotide binding|lymphocyte proliferation|positive regulation of cell-cell adhesion|phosphotransferase activity, alcohol group as acceptor|nucleus|adenosine kinase activity|purine-containing compound salvage|nucleoside triphosphate biosynthetic process|T cell proliferation|regulation of T cell activation|nucleoside monophosphate biosynthetic process|ribonucleotide metabolic process|nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|adenyl nucleotide binding|phosphorylation|positive regulation of homotypic cell-cell adhesion|nucleobase-containing compound kinase activity|leukocyte aggregation|deoxyribonucleotide biosynthetic process|purine nucleotide metabolic process|purine nucleobase metabolic process|poly(A) RNA binding|positive regulation of T cell activation|nucleotide biosynthetic process|positive regulation of lymphocyte proliferation|purine nucleoside metabolic process|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|cardiac muscle hypertrophy|nucleoside kinase activity|purine nucleotide biosynthetic process|deoxyribonucleoside triphosphate metabolic process|purine ribonucleoside salvage|purine nucleotide salvage|regulation of T cell proliferation|lymphocyte aggregation|ribonucleoside monophosphate biosynthetic process|positive regulation of T cell proliferation|purine ribonucleotide biosynthetic process|AMP metabolic process|AMP salvage|purine ribonucleoside monophosphate biosynthetic process|adenosine metabolic process|dATP metabolic process|dATP biosynthetic process|AMP biosynthetic process K00856 adenosine kinase[2.7.1.20] hsa01100|hsa00230 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human) 10:74151185-74709303 438 482 739 2512 2663 2039 6.37505315065268 6.37583136860643 9.69768427593151 32.7587069585508 31.8015744338591 27.8135039839535 7.48285626506354 30.7912617921211 -2.04086002026155 1.6405790313342e-19 1.23994547851775e-17 DOWN ENSG00000170921 TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [Source:HGNC Symbol;Acc:HGNC:30212] GO:0032502|GO:0005488|GO:0005515|GO:0048856|GO:0007275|GO:0009790|GO:0009792|GO:0043009|GO:0001701 developmental process|binding|protein binding|anatomical structure development|multicellular organism development|embryo development|embryo development ending in birth or egg hatching|chordate embryonic development|in utero embryonic development - - - - 17:63009556-63427699 134 164 363 1357 1435 1910 0.28056123314182 0.312065044871019 0.685238974854122 2.54565338489941 2.46513998722972 3.74786561907006 0.425955084288987 2.9195529970664 -2.77697428419638 1.69004795671781e-19 1.27410837625892e-17 DOWN ENSG00000157600 TMEM164 transmembrane protein 164 [Source:HGNC Symbol;Acc:HGNC:26217] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - X:110002631-110182734 236 317 339 1348 1169 1868 1.37364568313616 1.67687856362403 1.7790004332987 7.02991063889337 5.58270549545344 10.189859011554 1.60984156001963 7.6008250486336 -2.23923732178924 1.75418080175543e-19 1.31912628855433e-17 DOWN ENSG00000176749 CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) [Source:HGNC Symbol;Acc:HGNC:1775] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0031594|GO:0008283|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0051050|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0045926|GO:0044297|GO:0009653|GO:0016043|GO:0030427|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0060341|GO:0051726|GO:0007049|GO:0016337|GO:0006935|GO:0045595|GO:0006725|GO:0048468|GO:0043025|GO:0006810|GO:0022402|GO:0021766|GO:0051130|GO:1901360|GO:0010941|GO:0007275|GO:0045596|GO:0048513|GO:0048857|GO:0021548|GO:0032535|GO:0005102|GO:0016358|GO:0034641|GO:0008047|GO:0030902|GO:0030900|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0030426|GO:0007420|GO:0010942|GO:0098609|GO:0045786|GO:0043231|GO:0043169|GO:0019899|GO:0030308|GO:0005737|GO:0032970|GO:0032886|GO:0060322|GO:0021987|GO:0032880|GO:0051222|GO:0006928|GO:0043005|GO:0009966|GO:0045184|GO:0050839|GO:0009890|GO:0043197|GO:0036477|GO:0045787|GO:0014069|GO:0008037|GO:0032388|GO:0010646|GO:0006139|GO:0043085|GO:0008104|GO:0007154|GO:0060996|GO:0061024|GO:0022037|GO:0016477|GO:0007165|GO:0048588|GO:0048638|GO:0051649|GO:0016533|GO:0008219|GO:0090316|GO:0048640|GO:0021543|GO:0050790|GO:0030030|GO:0021549|GO:0019207|GO:0021819|GO:0048869|GO:0030029|GO:0021537|GO:0044249|GO:0007017|GO:0019538|GO:0001558|GO:0031324|GO:0031323|GO:0006996|GO:0060560|GO:0050768|GO:0032268|GO:0000902|GO:0060998|GO:0005829|GO:0031175|GO:0022029|GO:0007186|GO:0031344|GO:0010468|GO:0034645|GO:0090150|GO:0090068|GO:0046872|GO:0007166|GO:0032956|GO:0060997|GO:0030424|GO:0043412|GO:0007010|GO:0044309|GO:0050773|GO:0007417|GO:0010629|GO:0019887|GO:0070507|GO:0097061|GO:0048813|GO:0051252|GO:0032386|GO:1901216|GO:0070997|GO:0010721|GO:0051223|GO:0015031|GO:0021761|GO:0007050|GO:0000904|GO:0009790|GO:0051347|GO:0021885|GO:0036211|GO:0030517|GO:0070201|GO:0046907|GO:0001764|GO:0031345|GO:0043292|GO:0072657|GO:0031981|GO:0030425|GO:0010564|GO:0008361|GO:0051247|GO:0048471|GO:0008038|GO:0005654|GO:0022604|GO:0021586|GO:0046875|GO:0016301|GO:1901214|GO:0030036|GO:0034613|GO:0019900|GO:0032270|GO:0045296|GO:0012501|GO:0021795|GO:0006796|GO:0007158|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0030516|GO:0032990|GO:0019209|GO:0007399|GO:0097485|GO:0021722|GO:0051246|GO:0009059|GO:0030154|GO:0048858|GO:0043068|GO:1903827|GO:1902531|GO:0016070|GO:0000226|GO:0016773|GO:0090314|GO:0005634|GO:0043067|GO:1990138|GO:0051960|GO:0048666|GO:0008347|GO:0030182|GO:0007411|GO:0010975|GO:0033157|GO:0031401|GO:0007215|GO:0043065|GO:0071156|GO:0021799|GO:0010769|GO:0045892|GO:0043523|GO:0007413|GO:0032774|GO:2001141|GO:0043525|GO:0016310|GO:0006605|GO:1902679|GO:0005509|GO:0007213|GO:0061564|GO:0006886|GO:0051493|GO:0007167|GO:0030295|GO:0048814|GO:0042981|GO:0004672|GO:0051402|GO:0045665|GO:0019901|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0006612|GO:0000079|GO:0010977|GO:0061001|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0050771|GO:0048675|GO:0071158|GO:0033674|GO:1903533|GO:0007259|GO:0045859|GO:1903507|GO:0045860|GO:0035235|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0046425|GO:0043539|GO:0021801|GO:0042325|GO:0001932|GO:0018193|GO:0042063|GO:0004674|GO:0001934|GO:0097472|GO:0050770|GO:0045664|GO:0042327|GO:0007169|GO:0004693|GO:0048013|GO:0071902|GO:0042501|GO:0018105|GO:0016534|GO:0071900|GO:0018107|GO:0033136 locomotion|developmental process|growth|macromolecular complex|synapse|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|neuromuscular junction|cell proliferation|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell motility|regulation of signaling|negative regulation of growth|cell body|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|cell cycle|single organismal cell-cell adhesion|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|neuronal cell body|transport|cell cycle process|hippocampus development|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|animal organ development|neural nucleus development|pons development|regulation of cellular component size|receptor binding|dendrite development|cellular nitrogen compound metabolic process|enzyme activator activity|hindbrain development|forebrain development|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|growth cone|brain development|positive regulation of cell death|cell-cell adhesion|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|enzyme binding|negative regulation of cell growth|cytoplasm|regulation of actin filament-based process|regulation of microtubule-based process|head development|cerebral cortex development|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|neuron projection|regulation of signal transduction|establishment of protein localization|cell adhesion molecule binding|negative regulation of biosynthetic process|dendritic spine|somatodendritic compartment|positive regulation of cell cycle|postsynaptic density|cell recognition|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|cell communication|dendritic spine development|membrane organization|metencephalon development|cell migration|signal transduction|developmental cell growth|regulation of developmental growth|establishment of localization in cell|cyclin-dependent protein kinase 5 holoenzyme complex|cell death|positive regulation of intracellular protein transport|negative regulation of developmental growth|pallium development|regulation of catalytic activity|cell projection organization|cerebellum development|kinase regulator activity|layer formation in cerebral cortex|cellular developmental process|actin filament-based process|telencephalon development|cellular biosynthetic process|microtubule-based process|protein metabolic process|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|developmental growth involved in morphogenesis|negative regulation of neurogenesis|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|cytosol|neuron projection development|telencephalon cell migration|G-protein coupled receptor signaling pathway|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|positive regulation of cell cycle process|metal ion binding|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|dendritic spine morphogenesis|axon|macromolecule modification|cytoskeleton organization|neuron spine|regulation of dendrite development|central nervous system development|negative regulation of gene expression|protein kinase regulator activity|regulation of microtubule cytoskeleton organization|dendritic spine organization|dendrite morphogenesis|regulation of RNA metabolic process|regulation of intracellular transport|positive regulation of neuron death|neuron death|negative regulation of cell development|regulation of protein transport|protein transport|limbic system development|cell cycle arrest|cell morphogenesis involved in differentiation|embryo development|positive regulation of transferase activity|forebrain cell migration|protein modification process|negative regulation of axon extension|regulation of establishment of protein localization|intracellular transport|neuron migration|negative regulation of cell projection organization|contractile fiber|protein localization to membrane|nuclear lumen|dendrite|regulation of cell cycle process|regulation of cell size|positive regulation of protein metabolic process|perinuclear region of cytoplasm|neuron recognition|nucleoplasm|regulation of cell morphogenesis|pons maturation|ephrin receptor binding|kinase activity|regulation of neuron death|actin cytoskeleton organization|cellular protein localization|kinase binding|positive regulation of cellular protein metabolic process|cadherin binding|programmed cell death|cerebral cortex cell migration|phosphate-containing compound metabolic process|neuron cell-cell adhesion|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of axon extension|cell part morphogenesis|kinase activator activity|nervous system development|neuron projection guidance|superior olivary nucleus maturation|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|positive regulation of protein targeting to membrane|nucleus|regulation of programmed cell death|neuron projection extension|regulation of nervous system development|neuron development|glial cell migration|neuron differentiation|axon guidance|regulation of neuron projection development|regulation of intracellular protein transport|positive regulation of protein modification process|glutamate receptor signaling pathway|positive regulation of apoptotic process|regulation of cell cycle arrest|cerebral cortex radially oriented cell migration|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|axonal fasciculation|RNA biosynthetic process|regulation of RNA biosynthetic process|positive regulation of neuron apoptotic process|phosphorylation|protein targeting|negative regulation of RNA biosynthetic process|calcium ion binding|G-protein coupled acetylcholine receptor signaling pathway|axon development|intracellular protein transport|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|protein kinase activator activity|regulation of dendrite morphogenesis|regulation of apoptotic process|protein kinase activity|neuron apoptotic process|negative regulation of neuron differentiation|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|protein targeting to membrane|regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of neuron projection development|regulation of dendritic spine morphogenesis|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|negative regulation of axonogenesis|axon extension|positive regulation of cell cycle arrest|positive regulation of kinase activity|regulation of protein targeting|JAK-STAT cascade|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|ionotropic glutamate receptor signaling pathway|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of JAK-STAT cascade|protein serine/threonine kinase activator activity|cerebral cortex radial glia guided migration|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|gliogenesis|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|cyclin-dependent protein kinase activity|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|cyclin-dependent protein serine/threonine kinase activity|ephrin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|serine phosphorylation of STAT protein|peptidyl-serine phosphorylation|cyclin-dependent protein kinase 5 activator activity|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|serine phosphorylation of STAT3 protein K11716 cyclin-dependent kinase 5 activator 1[-] hsa05010|hsa05030 Alzheimer,s disease - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human) 17:32486619-32491256 444 417 276 53 64 60 5.54896814308499 4.7363666769664 3.10994259940226 0.593478623824058 0.65625780346792 0.702762957582314 4.46509247315122 0.650833128291431 2.77833046108921 1.78368115247845e-19 1.33794012879628e-17 UP ENSG00000278978 RP11-164P12.5 - - - - - - - 4:151669786-151670503 2 0 2 54 49 65 0.197029423253942 0 0.177654740937921 4.76662646844705 3.96083231658172 6.00158437821015 0.124894721397288 4.90968105441297 -5.29684489769989 1.79140456059198e-19 1.34036570806799e-17 DOWN ENSG00000108021 FAM208B family with sequence similarity 208 member B [Source:HGNC Symbol;Acc:HGNC:23484] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nuclear lumen|nucleoplasm|nucleus - - - - 10:5684838-5763740 391 430 516 1631 1964 1588 1.90679870398042 1.90579805193489 2.26877677364396 7.12655471624895 7.8584591653307 7.25783869645925 2.02712450985309 7.41428419267963 -1.87087271072706 1.84764079034782e-19 1.3789867038761e-17 DOWN ENSG00000003436 TFPI tissue factor pathway inhibitor [Source:HGNC Symbol;Acc:HGNC:11760] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009986|GO:0044237|GO:0043227|GO:0071944|GO:0031224|GO:0005615|GO:0030234|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0031225|GO:0050817|GO:0004857|GO:0007598|GO:0043231|GO:0005737|GO:0009611|GO:0072378|GO:0044092|GO:0005783|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0050878|GO:0032268|GO:0030414|GO:0007596|GO:0032269|GO:0042060|GO:0007599|GO:0051346|GO:0006508|GO:0044267|GO:0051246|GO:0004866|GO:0010466|GO:0030162|GO:0052547|GO:0045861|GO:0010951|GO:0004867|GO:0052548 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cell surface|cellular metabolic process|membrane-bounded organelle|cell periphery|intrinsic component of membrane|extracellular space|enzyme regulator activity|intracellular|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|anchored component of membrane|coagulation|enzyme inhibitor activity|blood coagulation, extrinsic pathway|intracellular membrane-bounded organelle|cytoplasm|response to wounding|blood coagulation, fibrin clot formation|negative regulation of molecular function|endoplasmic reticulum|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|regulation of cellular protein metabolic process|peptidase inhibitor activity|blood coagulation|negative regulation of cellular protein metabolic process|wound healing|hemostasis|negative regulation of hydrolase activity|proteolysis|cellular protein metabolic process|regulation of protein metabolic process|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of proteolysis|regulation of peptidase activity|negative regulation of proteolysis|negative regulation of endopeptidase activity|serine-type endopeptidase inhibitor activity|regulation of endopeptidase activity K03909 tissue factor pathway inhibitor[-] hsa04610 Complement and coagulation cascades - Homo sapiens (human) 2:187464230-187565760 127 126 213 1005 681 1106 0.533024397210442 0.480609947903332 0.806002014913636 3.77925767828203 2.34507952464445 4.35037807535652 0.60654545334247 3.49157175942767 -2.52518895627786 1.86167867204504e-19 1.38599887968161e-17 DOWN ENSG00000135919 SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 [Source:HGNC Symbol;Acc:HGNC:8951] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0000003|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0019898|GO:0009892|GO:0048523|GO:0031594|GO:0051606|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0016049|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0009986|GO:0019953|GO:0051051|GO:0044237|GO:0003006|GO:0048870|GO:0023051|GO:0045926|GO:0044297|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0040008|GO:0009605|GO:0023057|GO:0032504|GO:0005615|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048609|GO:0019222|GO:0007618|GO:0042127|GO:0050817|GO:0016337|GO:0004857|GO:0008201|GO:0021681|GO:0050804|GO:0045595|GO:0009897|GO:0009888|GO:0048468|GO:0043025|GO:0009314|GO:0006810|GO:0035295|GO:0051130|GO:0009612|GO:0007275|GO:0048513|GO:0050877|GO:0005102|GO:0043168|GO:0021587|GO:0032940|GO:0030902|GO:0030155|GO:0031982|GO:0051128|GO:0007566|GO:0007420|GO:0050806|GO:0098609|GO:0009582|GO:0050803|GO:0030141|GO:0045597|GO:0043231|GO:0048608|GO:0030308|GO:0005737|GO:0007267|GO:0009611|GO:0060322|GO:0006928|GO:0050819|GO:0001775|GO:0009966|GO:0019897|GO:0036477|GO:0060384|GO:0010646|GO:0007320|GO:0021696|GO:0007162|GO:0021695|GO:0050906|GO:0050865|GO:0007154|GO:0044092|GO:0007565|GO:0022037|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0021675|GO:0008285|GO:0050790|GO:0030030|GO:0021549|GO:0043086|GO:0048869|GO:2000145|GO:0061110|GO:0021683|GO:0019538|GO:0005539|GO:0001558|GO:0031324|GO:0031323|GO:0010256|GO:0048732|GO:0050878|GO:0021575|GO:0043271|GO:0006996|GO:0032268|GO:0005829|GO:0031175|GO:0031344|GO:0010468|GO:0030193|GO:0030168|GO:0048167|GO:0016050|GO:0007166|GO:0033363|GO:0061458|GO:0030163|GO:0007417|GO:0031410|GO:0010629|GO:0010720|GO:0010544|GO:0030414|GO:0007596|GO:0042628|GO:0034109|GO:0051604|GO:0008589|GO:0031346|GO:0045879|GO:0030334|GO:0016023|GO:0061108|GO:0032269|GO:0042060|GO:0006811|GO:0030195|GO:0022408|GO:0007600|GO:0022407|GO:0010766|GO:0050769|GO:0007599|GO:0051966|GO:0051346|GO:0006508|GO:0031988|GO:0007620|GO:0007617|GO:0043269|GO:0061045|GO:0010543|GO:0050982|GO:0060291|GO:0060429|GO:0031232|GO:0035556|GO:0050974|GO:0044267|GO:0042176|GO:0010467|GO:0007399|GO:0046903|GO:1902532|GO:0051246|GO:0030154|GO:1902531|GO:0031091|GO:0042177|GO:0051960|GO:0048505|GO:0048666|GO:0030182|GO:0004866|GO:0010466|GO:0010975|GO:0010001|GO:0070527|GO:0050954|GO:0016485|GO:0030162|GO:0006812|GO:0007224|GO:0090330|GO:0052547|GO:0048017|GO:0014015|GO:0014067|GO:0045861|GO:0034111|GO:0090331|GO:0014066|GO:0022008|GO:0050767|GO:0010976|GO:0048708|GO:0061041|GO:0045666|GO:0048710|GO:0048015|GO:0010955|GO:0048699|GO:0014013|GO:0045685|GO:0048711|GO:0070613|GO:0010951|GO:0045687|GO:0042063|GO:0002028|GO:0031638|GO:0030001|GO:0004867|GO:0045664|GO:0015672|GO:0007268|GO:0052548|GO:0007270|GO:0006814|GO:0014065|GO:0010757|GO:0031639|GO:0035249 locomotion|developmental process|extracellular matrix|growth|reproduction|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|negative regulation of metabolic process|negative regulation of cellular process|neuromuscular junction|detection of stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|cell growth|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cell surface|sexual reproduction|negative regulation of transport|cellular metabolic process|developmental process involved in reproduction|cell motility|regulation of signaling|negative regulation of growth|cell body|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|regulation of growth|response to external stimulus|negative regulation of signaling|multicellular organism reproduction|extracellular space|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|mating|regulation of cell proliferation|coagulation|single organismal cell-cell adhesion|enzyme inhibitor activity|heparin binding|cerebellar granular layer development|modulation of synaptic transmission|regulation of cell differentiation|external side of plasma membrane|tissue development|cell development|neuronal cell body|response to radiation|transport|tube development|positive regulation of cellular component organization|response to mechanical stimulus|multicellular organism development|animal organ development|neurological system process|receptor binding|anion binding|cerebellum morphogenesis|secretion by cell|hindbrain development|regulation of cell adhesion|vesicle|regulation of cellular component organization|embryo implantation|brain development|positive regulation of synaptic transmission|cell-cell adhesion|detection of abiotic stimulus|regulation of synapse structure or activity|secretory granule|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|negative regulation of cell growth|cytoplasm|cell-cell signaling|response to wounding|head development|movement of cell or subcellular component|negative regulation of coagulation|cell activation|regulation of signal transduction|extrinsic component of plasma membrane|somatodendritic compartment|innervation|regulation of cell communication|insemination|cerebellar cortex morphogenesis|negative regulation of cell adhesion|cerebellar cortex development|detection of stimulus involved in sensory perception|regulation of cell activation|cell communication|negative regulation of molecular function|female pregnancy|metencephalon development|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|nerve development|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|cerebellum development|negative regulation of catalytic activity|cellular developmental process|regulation of cell motility|dense core granule biogenesis|cerebellar granular layer morphogenesis|protein metabolic process|glycosaminoglycan binding|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endomembrane system organization|gland development|regulation of body fluid levels|hindbrain morphogenesis|negative regulation of ion transport|organelle organization|regulation of cellular protein metabolic process|cytosol|neuron projection development|regulation of cell projection organization|regulation of gene expression|regulation of blood coagulation|platelet activation|regulation of synaptic plasticity|vesicle organization|cell surface receptor signaling pathway|secretory granule organization|reproductive system development|protein catabolic process|central nervous system development|cytoplasmic vesicle|negative regulation of gene expression|positive regulation of cell development|negative regulation of platelet activation|peptidase inhibitor activity|blood coagulation|mating plug formation|homotypic cell-cell adhesion|protein maturation|regulation of smoothened signaling pathway|positive regulation of cell projection organization|negative regulation of smoothened signaling pathway|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|seminal vesicle epithelium development|negative regulation of cellular protein metabolic process|wound healing|ion transport|negative regulation of blood coagulation|negative regulation of cell-cell adhesion|sensory perception|regulation of cell-cell adhesion|negative regulation of sodium ion transport|positive regulation of neurogenesis|hemostasis|regulation of synaptic transmission, glutamatergic|negative regulation of hydrolase activity|proteolysis|membrane-bounded vesicle|copulation|mating behavior|regulation of ion transport|negative regulation of wound healing|regulation of platelet activation|detection of mechanical stimulus|long-term synaptic potentiation|epithelium development|extrinsic component of external side of plasma membrane|intracellular signal transduction|detection of mechanical stimulus involved in sensory perception|cellular protein metabolic process|regulation of protein catabolic process|gene expression|nervous system development|secretion|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|regulation of intracellular signal transduction|platelet alpha granule|negative regulation of protein catabolic process|regulation of nervous system development|regulation of timing of cell differentiation|neuron development|neuron differentiation|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of neuron projection development|glial cell differentiation|platelet aggregation|sensory perception of mechanical stimulus|protein processing|regulation of proteolysis|cation transport|smoothened signaling pathway|regulation of platelet aggregation|regulation of peptidase activity|inositol lipid-mediated signaling|positive regulation of gliogenesis|negative regulation of phosphatidylinositol 3-kinase signaling|negative regulation of proteolysis|negative regulation of homotypic cell-cell adhesion|negative regulation of platelet aggregation|regulation of phosphatidylinositol 3-kinase signaling|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|astrocyte differentiation|regulation of wound healing|positive regulation of neuron differentiation|regulation of astrocyte differentiation|phosphatidylinositol-mediated signaling|negative regulation of protein processing|generation of neurons|regulation of gliogenesis|regulation of glial cell differentiation|positive regulation of astrocyte differentiation|regulation of protein processing|negative regulation of endopeptidase activity|positive regulation of glial cell differentiation|gliogenesis|regulation of sodium ion transport|zymogen activation|metal ion transport|serine-type endopeptidase inhibitor activity|regulation of neuron differentiation|monovalent inorganic cation transport|synaptic transmission|regulation of endopeptidase activity|neuron-neuron synaptic transmission|sodium ion transport|phosphatidylinositol 3-kinase signaling|negative regulation of plasminogen activation|plasminogen activation|synaptic transmission, glutamatergic - - - - 2:223975112-224039319 1115 1199 1933 6439 6768 5370 6.58745512151239 6.43786573680597 10.2964840860974 34.0846535186607 32.8073437062315 29.7334970598932 7.77393498147192 32.2084980949285 -2.05072444176464 2.08140545812138e-19 1.5457283220586e-17 DOWN ENSG00000158169 FANCC Fanconi anemia complementation group C [Source:HGNC Symbol;Acc:HGNC:3584] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0000785|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0006281|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0022607|GO:0043231|GO:0005737|GO:0006139|GO:0000422|GO:0016236|GO:0043240|GO:0006996|GO:0005829|GO:1903008|GO:0000423|GO:0007005|GO:0036297|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0006461|GO:0005634|GO:0006974|GO:0098779 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|chromatin|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|mitophagy|macroautophagy|Fanconi anaemia nuclear complex|organelle organization|cytosol|organelle disassembly|macromitophagy|mitochondrion organization|interstrand cross-link repair|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|protein complex assembly|nucleus|cellular response to DNA damage stimulus|mitophagy in response to mitochondrial depolarization K10890 fanconi anemia group C protein[-] hsa03460 Fanconi anemia pathway - Homo sapiens (human) 9:95099054-95317709 86 113 161 612 684 551 0.516063068997098 0.616261923955949 0.871058088923718 3.29044786487461 3.36767067100117 3.09874697080919 0.667794360625588 3.25228850222832 -2.28397942556429 2.23243130639452e-19 1.6537718169008e-17 DOWN ENSG00000049323 LTBP1 latent transforming growth factor beta binding protein 1 [Source:HGNC Symbol;Acc:HGNC:6714] GO:0032502|GO:0031012|GO:0032991|GO:0004871|GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0043205|GO:0004872|GO:0048523|GO:0050794|GO:0005578|GO:0043167|GO:0038023|GO:0023051|GO:0016043|GO:0023057|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0050436|GO:0007507|GO:0019838|GO:0001568|GO:0007275|GO:0048513|GO:0043062|GO:0016772|GO:0090287|GO:0043169|GO:0004888|GO:0071559|GO:0009966|GO:0001527|GO:0010646|GO:0090288|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0003279|GO:0019955|GO:0010033|GO:0003205|GO:0046872|GO:0090101|GO:0007166|GO:0050431|GO:0001944|GO:0072358|GO:0060976|GO:1900116|GO:0060840|GO:0071560|GO:0003231|GO:0070848|GO:0016301|GO:0071310|GO:0030198|GO:0003281|GO:0072359|GO:0016773|GO:0035583|GO:0071363|GO:0004675|GO:0005509|GO:0007179|GO:0030512|GO:0007167|GO:0035904|GO:0004672|GO:0035581|GO:0017015|GO:0004674|GO:0005024|GO:0007178 developmental process|extracellular matrix|macromolecular complex|signal transducer activity|signaling|cellular process|extracellular region|response to stimulus|binding|catalytic activity|cellular response to stimulus|fibril|receptor activity|negative regulation of cellular process|regulation of cellular process|proteinaceous extracellular matrix|ion binding|signaling receptor activity|regulation of signaling|cellular component organization|negative regulation of signaling|protein binding|protein complex|transferase activity|anatomical structure development|microfibril binding|heart development|growth factor binding|blood vessel development|multicellular organism development|animal organ development|extracellular structure organization|transferase activity, transferring phosphorus-containing groups|regulation of cellular response to growth factor stimulus|cation binding|transmembrane signaling receptor activity|response to transforming growth factor beta|regulation of signal transduction|microfibril|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|protein localization|cell communication|signal transduction|negative regulation of signal transduction|cardiac septum development|cytokine binding|response to organic substance|cardiac chamber development|metal ion binding|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|transforming growth factor beta binding|vasculature development|cardiovascular system development|coronary vasculature development|extracellular negative regulation of signal transduction|artery development|cellular response to transforming growth factor beta stimulus|cardiac ventricle development|response to growth factor|kinase activity|cellular response to organic substance|extracellular matrix organization|ventricular septum development|circulatory system development|phosphotransferase activity, alcohol group as acceptor|sequestering of TGFbeta in extracellular matrix|cellular response to growth factor stimulus|transmembrane receptor protein serine/threonine kinase activity|calcium ion binding|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|aorta development|protein kinase activity|sequestering of extracellular ligand from receptor|regulation of transforming growth factor beta receptor signaling pathway|protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transmembrane receptor protein serine/threonine kinase signaling pathway K19559 latent transforming growth factor beta binding protein 1[-] hsa04350 TGF-beta signaling pathway - Homo sapiens (human) 2:32946972-33399509 80 86 139 502 569 720 0.412640373315502 0.403143355607407 0.64641356338815 2.31997214518202 2.40803097309377 3.48051119992279 0.48739909743702 2.73617143939953 -2.48898314292587 2.26112590635924e-19 1.67088249525863e-17 DOWN ENSG00000170871 KIAA0232 KIAA0232 [Source:HGNC Symbol;Acc:HGNC:28992] GO:0005488|GO:0036094|GO:0097159|GO:0043167|GO:0043168|GO:0001882|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005524|GO:0030554 binding|small molecule binding|organic cyclic compound binding|ion binding|anion binding|nucleoside binding|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|ATP binding|adenyl nucleotide binding - - - - 4:6781375-6884170 333 359 430 1382 1515 1381 1.92493011092554 1.88601551614316 2.24105811282959 7.15775017282761 7.18540790630388 7.48158115526225 2.0173345799661 7.27491307813125 -1.85047963220204 2.33529711507744e-19 1.72143111292646e-17 DOWN ENSG00000083123 BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide [Source:HGNC Symbol;Acc:HGNC:987] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0016830|GO:0006082|GO:0034641|GO:0044281|GO:0003826|GO:0043231|GO:0005737|GO:0006520|GO:0016903|GO:0045239|GO:0055114|GO:0009081|GO:0009063|GO:0016831|GO:0005759|GO:0005739|GO:0005947|GO:0016624|GO:0009083|GO:0003863|GO:0046395|GO:0019752 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|carbon-carbon lyase activity|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|alpha-ketoacid dehydrogenase activity|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors|tricarboxylic acid cycle enzyme complex|oxidation-reduction process|branched-chain amino acid metabolic process|cellular amino acid catabolic process|carboxy-lyase activity|mitochondrial matrix|mitochondrion|mitochondrial alpha-ketoglutarate dehydrogenase complex|oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor|branched-chain amino acid catabolic process|3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|carboxylic acid catabolic process|carboxylic acid metabolic process K00167 2-oxoisovalerate dehydrogenase E1 component beta subunit[1.2.4.4] hsa01100|hsa00280|hsa00640 Metabolic pathways - Homo sapiens (human)|Valine, leucine and isoleucine degradation - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human) 6:80106647-80346270 54 65 98 385 415 431 0.811862100328928 0.88814135171039 1.32839863952613 5.18614809266329 5.11919994177411 6.07284858917471 1.00946736385515 5.45939887453737 -2.43514783810368 2.35962113402841e-19 1.73507707722375e-17 DOWN ENSG00000198369 SPRED2 sprouty-related, EVH1 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:17722] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0023057|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0004857|GO:2001022|GO:0007275|GO:0005102|GO:0031982|GO:0033554|GO:0043231|GO:0030133|GO:0019899|GO:0005737|GO:0012506|GO:0009966|GO:0030658|GO:0010646|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0050790|GO:0019207|GO:0043086|GO:0009967|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0019210|GO:0005126|GO:0043412|GO:0031410|GO:0019887|GO:0016023|GO:0036211|GO:0032269|GO:0043517|GO:2001020|GO:0031988|GO:0019900|GO:0006796|GO:0035556|GO:0030659|GO:0044267|GO:0051174|GO:1902532|GO:0051246|GO:1902531|GO:0006974|GO:1901798|GO:0005173|GO:0043408|GO:0072331|GO:0042770|GO:0016310|GO:0004860|GO:1901796|GO:0043409|GO:0033673|GO:0019901|GO:0006464|GO:0043549|GO:0043516|GO:0030291|GO:0045859|GO:0006469|GO:0006468|GO:0043407|GO:0090311|GO:0043405|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:0001933|GO:0030330|GO:0071901|GO:0000188|GO:0006476|GO:0010801|GO:0071900|GO:0018107 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|negative regulation of signaling|enzyme regulator activity|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|enzyme inhibitor activity|positive regulation of response to DNA damage stimulus|multicellular organism development|receptor binding|vesicle|cellular response to stress|intracellular membrane-bounded organelle|transport vesicle|enzyme binding|cytoplasm|vesicle membrane|regulation of signal transduction|transport vesicle membrane|regulation of cell communication|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|kinase inhibitor activity|cytokine receptor binding|macromolecule modification|cytoplasmic vesicle|protein kinase regulator activity|cytoplasmic, membrane-bounded vesicle|protein modification process|negative regulation of cellular protein metabolic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|regulation of response to DNA damage stimulus|membrane-bounded vesicle|kinase binding|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic vesicle membrane|cellular protein metabolic process|regulation of phosphorus metabolic process|negative regulation of intracellular signal transduction|regulation of protein metabolic process|regulation of intracellular signal transduction|cellular response to DNA damage stimulus|positive regulation of signal transduction by p53 class mediator|stem cell factor receptor binding|regulation of MAPK cascade|signal transduction by p53 class mediator|signal transduction in response to DNA damage|phosphorylation|protein kinase inhibitor activity|regulation of signal transduction by p53 class mediator|negative regulation of MAPK cascade|negative regulation of kinase activity|protein kinase binding|cellular protein modification process|regulation of kinase activity|regulation of DNA damage response, signal transduction by p53 class mediator|protein serine/threonine kinase inhibitor activity|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|negative regulation of MAP kinase activity|regulation of protein deacetylation|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|negative regulation of protein phosphorylation|DNA damage response, signal transduction by p53 class mediator|negative regulation of protein serine/threonine kinase activity|inactivation of MAPK activity|protein deacetylation|negative regulation of peptidyl-threonine phosphorylation|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation - - - - 2:65310851-65432637 185 204 345 1119 1302 996 1.64794592928158 1.65150606021032 2.77079216444521 8.93096204937619 9.51589424985207 8.31493809000814 2.02341471797904 8.92059812974547 -2.1403484024869 2.37723023758235e-19 1.7437305039996e-17 DOWN ENSG00000204406 MBD5 methyl-CpG binding domain protein 5 [Source:HGNC Symbol;Acc:HGNC:20444] GO:0032502|GO:0040007|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0009056|GO:0006914|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0044708|GO:0040008|GO:0009607|GO:0009605|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0048856|GO:0007275|GO:0050688|GO:0003676|GO:0006952|GO:0031982|GO:0033554|GO:0098542|GO:0043231|GO:0010243|GO:0035264|GO:0042592|GO:0009615|GO:0009966|GO:0003682|GO:0010646|GO:0007154|GO:0007165|GO:0000422|GO:0070062|GO:0048638|GO:0009725|GO:0040014|GO:0016236|GO:0051607|GO:0009967|GO:0010033|GO:0006996|GO:0003677|GO:1903008|GO:0098792|GO:0007166|GO:0000423|GO:0007005|GO:0048878|GO:1901652|GO:0071417|GO:0060399|GO:0043434|GO:0060398|GO:0005694|GO:0007399|GO:0071310|GO:0032870|GO:0005634|GO:0050691|GO:1901653|GO:0010369|GO:0060416|GO:0002230|GO:0007167|GO:0071375|GO:0098779|GO:0033500|GO:0042593|GO:0071378|GO:0007169|GO:0060396 developmental process|growth|immune system process|behavior|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|catabolic process|autophagy|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|single-organism behavior|regulation of growth|response to biotic stimulus|response to external stimulus|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|anatomical structure development|multicellular organism development|regulation of defense response to virus|nucleic acid binding|defense response|vesicle|cellular response to stress|defense response to other organism|intracellular membrane-bounded organelle|response to organonitrogen compound|multicellular organism growth|homeostatic process|response to virus|regulation of signal transduction|chromatin binding|regulation of cell communication|cell communication|signal transduction|mitophagy|extracellular exosome|regulation of developmental growth|response to hormone|regulation of multicellular organism growth|macroautophagy|defense response to virus|positive regulation of signal transduction|response to organic substance|organelle organization|DNA binding|organelle disassembly|xenophagy|cell surface receptor signaling pathway|macromitophagy|mitochondrion organization|chemical homeostasis|response to peptide|cellular response to organonitrogen compound|positive regulation of growth hormone receptor signaling pathway|response to peptide hormone|regulation of growth hormone receptor signaling pathway|chromosome|nervous system development|cellular response to organic substance|cellular response to hormone stimulus|nucleus|regulation of defense response to virus by host|cellular response to peptide|chromocenter|response to growth hormone|positive regulation of defense response to virus by host|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|mitophagy in response to mitochondrial depolarization|carbohydrate homeostasis|glucose homeostasis|cellular response to growth hormone stimulus|transmembrane receptor protein tyrosine kinase signaling pathway|growth hormone receptor signaling pathway - - - - 2:148021011-148516971 19 26 42 191 260 290 0.0536922546638003 0.0667759919322363 0.107011762834415 0.483613362611447 0.602849649668455 0.768058157047338 0.0758266698101505 0.61817372310908 -3.02723506194994 2.38633934998286e-19 1.74612193515658e-17 DOWN ENSG00000099250 NRP1 neuropilin 1 [Source:HGNC Symbol;Acc:HGNC:8004] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0040013|GO:0042995|GO:0004872|GO:0030055|GO:0048523|GO:0048521|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0016049|GO:0048520|GO:0071704|GO:0043167|GO:0009986|GO:0044237|GO:0051641|GO:0050795|GO:0038023|GO:0048870|GO:0023051|GO:0045926|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0030427|GO:0045927|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0031224|GO:0005615|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0008284|GO:0051272|GO:0042127|GO:0008201|GO:0006935|GO:0045595|GO:0035239|GO:0060041|GO:0001822|GO:0009888|GO:0048468|GO:0043025|GO:0019838|GO:0006810|GO:0035295|GO:0051130|GO:0048839|GO:0001568|GO:0010941|GO:0007275|GO:0010632|GO:0060627|GO:0045596|GO:0048513|GO:0061299|GO:0032535|GO:0016358|GO:0043168|GO:0030307|GO:0005924|GO:0030900|GO:0005912|GO:0016772|GO:0031982|GO:0031325|GO:0051128|GO:2000147|GO:0030426|GO:0007420|GO:0005882|GO:0051098|GO:0045597|GO:0043231|GO:0043169|GO:0004888|GO:0021854|GO:0030308|GO:0005737|GO:0007389|GO:0001763|GO:0007267|GO:0009611|GO:0060322|GO:0021987|GO:0050920|GO:0007423|GO:0043235|GO:0006928|GO:0009887|GO:0043005|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0050673|GO:0048639|GO:0036477|GO:0060384|GO:0008037|GO:0060548|GO:0010646|GO:0001525|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0009968|GO:0048638|GO:0019955|GO:0050922|GO:0021675|GO:0030916|GO:0008219|GO:0051271|GO:0048532|GO:0021602|GO:0010634|GO:0048640|GO:0021543|GO:0030030|GO:0015026|GO:0048869|GO:0016021|GO:2000145|GO:0021537|GO:0009967|GO:0019538|GO:0023014|GO:0005539|GO:0010033|GO:0001558|GO:0031323|GO:0021536|GO:0048732|GO:0005768|GO:0050921|GO:0060560|GO:0050768|GO:0000165|GO:0016192|GO:0050679|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0022029|GO:0048485|GO:0031344|GO:0002040|GO:0017154|GO:0061441|GO:0090132|GO:1901998|GO:1901215|GO:0005883|GO:0046872|GO:0007166|GO:0001654|GO:0002009|GO:0001569|GO:0030424|GO:0001944|GO:0043412|GO:0060978|GO:0072358|GO:0007417|GO:0031410|GO:0001655|GO:0043583|GO:0010720|GO:0005769|GO:0060976|GO:0043069|GO:0048483|GO:2001234|GO:0009880|GO:0070997|GO:0048754|GO:0010721|GO:0061138|GO:0021761|GO:0031346|GO:0022612|GO:0000904|GO:0009790|GO:0030334|GO:0001935|GO:0001667|GO:0043049|GO:0021885|GO:0036211|GO:0030517|GO:0048486|GO:0060840|GO:0048844|GO:0001764|GO:0021979|GO:0072001|GO:0031345|GO:0042472|GO:0003002|GO:0007431|GO:0060485|GO:0060326|GO:0050769|GO:0060977|GO:0001708|GO:0008361|GO:0061548|GO:0051099|GO:0051247|GO:0070848|GO:0008038|GO:0022604|GO:0060385|GO:0021855|GO:0050678|GO:0016301|GO:0035272|GO:1901214|GO:0002116|GO:0034613|GO:0021872|GO:0021636|GO:0032270|GO:0012501|GO:0060429|GO:0021795|GO:0006796|GO:0035556|GO:0006929|GO:0044267|GO:0051174|GO:0048864|GO:0050918|GO:0030516|GO:0097443|GO:0032990|GO:0038085|GO:0048562|GO:0007399|GO:0060562|GO:0071310|GO:0097485|GO:0010594|GO:0051246|GO:0071599|GO:0010770|GO:0061298|GO:0030154|GO:0048858|GO:0030335|GO:0060837|GO:0021610|GO:1902531|GO:0072359|GO:0016773|GO:1902667|GO:0005856|GO:0043067|GO:1990138|GO:0051960|GO:0045165|GO:0010595|GO:0005925|GO:0097190|GO:0045773|GO:0043393|GO:0021545|GO:0048666|GO:1902336|GO:0030182|GO:2001237|GO:0035728|GO:0003158|GO:0007411|GO:0021637|GO:0071600|GO:0021953|GO:0001755|GO:0021800|GO:0048863|GO:0010975|GO:0033365|GO:0031401|GO:0030855|GO:0043408|GO:0010769|GO:0097491|GO:0043010|GO:0043523|GO:0048841|GO:0021559|GO:0007413|GO:0014909|GO:0014031|GO:1902285|GO:0061550|GO:2001236|GO:0071363|GO:0016310|GO:0014910|GO:0070371|GO:0002042|GO:0035767|GO:0061564|GO:0021828|GO:0001936|GO:1904835|GO:0097490|GO:0048842|GO:0060445|GO:0042471|GO:0090259|GO:0007167|GO:0014911|GO:0097102|GO:0021649|GO:0032092|GO:0021954|GO:1901166|GO:0061549|GO:0043410|GO:0045111|GO:0021562|GO:0010631|GO:0042981|GO:1990791|GO:0043066|GO:0001938|GO:0004672|GO:0072148|GO:0048762|GO:0007435|GO:0051402|GO:0021879|GO:0045665|GO:0071526|GO:0043524|GO:0060982|GO:0050772|GO:0022008|GO:0048667|GO:0004714|GO:0006464|GO:0050767|GO:0048843|GO:0021612|GO:0048812|GO:0097191|GO:0010976|GO:0010977|GO:0035282|GO:0006915|GO:0050771|GO:0048675|GO:0045666|GO:0014033|GO:0014032|GO:0045446|GO:0061551|GO:0005021|GO:0097374|GO:0007409|GO:0006468|GO:0008045|GO:0048699|GO:1902378|GO:0035729|GO:0042325|GO:0038190|GO:0035924|GO:1900122|GO:0004713|GO:0070374|GO:0001932|GO:0018193|GO:0060666|GO:1902287|GO:0071679|GO:0021884|GO:0001934|GO:1903375|GO:0036010|GO:0070372|GO:0031290|GO:0048846|GO:0043542|GO:0050770|GO:0045664|GO:0042327|GO:0097101|GO:0007169|GO:0060300|GO:0036486|GO:0048010|GO:0050731|GO:0021785|GO:0050730|GO:0048008|GO:0060301|GO:1902946|GO:0038084|GO:0048012|GO:0018108|GO:0043534 locomotion|developmental process|growth|macromolecular complex|signal transducer activity|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of locomotion|cell projection|receptor activity|cell-substrate junction|negative regulation of cellular process|negative regulation of behavior|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|cell growth|positive regulation of behavior|organic substance metabolic process|ion binding|cell surface|cellular metabolic process|cellular localization|regulation of behavior|signaling receptor activity|cell motility|regulation of signaling|negative regulation of growth|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|site of polarized growth|positive regulation of growth|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|extracellular space|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|heparin binding|chemotaxis|regulation of cell differentiation|tube morphogenesis|retina development in camera-type eye|kidney development|tissue development|cell development|neuronal cell body|growth factor binding|transport|tube development|positive regulation of cellular component organization|inner ear development|blood vessel development|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|regulation of vesicle-mediated transport|negative regulation of cell differentiation|animal organ development|retina vasculature morphogenesis in camera-type eye|regulation of cellular component size|dendrite development|anion binding|positive regulation of cell growth|cell-substrate adherens junction|forebrain development|adherens junction|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|growth cone|brain development|intermediate filament|regulation of binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|transmembrane signaling receptor activity|hypothalamus development|negative regulation of cell growth|cytoplasm|pattern specification process|morphogenesis of a branching structure|cell-cell signaling|response to wounding|head development|cerebral cortex development|regulation of chemotaxis|sensory organ development|receptor complex|movement of cell or subcellular component|organ morphogenesis|neuron projection|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|epithelial cell proliferation|positive regulation of developmental growth|somatodendritic compartment|innervation|cell recognition|negative regulation of cell death|regulation of cell communication|angiogenesis|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|negative regulation of signal transduction|regulation of developmental growth|cytokine binding|negative regulation of chemotaxis|nerve development|otic vesicle formation|cell death|negative regulation of cellular component movement|anatomical structure arrangement|cranial nerve morphogenesis|positive regulation of epithelial cell migration|negative regulation of developmental growth|pallium development|cell projection organization|coreceptor activity|cellular developmental process|integral component of membrane|regulation of cell motility|telencephalon development|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|glycosaminoglycan binding|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|diencephalon development|gland development|endosome|positive regulation of chemotaxis|developmental growth involved in morphogenesis|negative regulation of neurogenesis|MAPK cascade|vesicle-mediated transport|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|telencephalon cell migration|sympathetic nervous system development|regulation of cell projection organization|sprouting angiogenesis|semaphorin receptor activity|renal artery morphogenesis|epithelium migration|toxin transport|negative regulation of neuron death|neurofilament|metal ion binding|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|patterning of blood vessels|axon|vasculature development|macromolecule modification|angiogenesis involved in coronary vascular morphogenesis|cardiovascular system development|central nervous system development|cytoplasmic vesicle|urogenital system development|ear development|positive regulation of cell development|early endosome|coronary vasculature development|negative regulation of programmed cell death|autonomic nervous system development|negative regulation of apoptotic signaling pathway|embryonic pattern specification|neuron death|branching morphogenesis of an epithelial tube|negative regulation of cell development|morphogenesis of a branching epithelium|limbic system development|positive regulation of cell projection organization|gland morphogenesis|cell morphogenesis involved in differentiation|embryo development|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|otic placode formation|forebrain cell migration|protein modification process|negative regulation of axon extension|parasympathetic nervous system development|artery development|artery morphogenesis|neuron migration|hypothalamus cell differentiation|renal system development|negative regulation of cell projection organization|inner ear morphogenesis|regionalization|salivary gland development|mesenchyme development|cell chemotaxis|positive regulation of neurogenesis|coronary vasculature morphogenesis|cell fate specification|regulation of cell size|ganglion development|positive regulation of binding|positive regulation of protein metabolic process|response to growth factor|neuron recognition|regulation of cell morphogenesis|axonogenesis involved in innervation|hypothalamus cell migration|regulation of epithelial cell proliferation|kinase activity|exocrine system development|regulation of neuron death|semaphorin receptor complex|cellular protein localization|forebrain generation of neurons|trigeminal nerve morphogenesis|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|cerebral cortex cell migration|phosphate-containing compound metabolic process|intracellular signal transduction|substrate-dependent cell migration|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|positive chemotaxis|regulation of axon extension|sorting endosome|cell part morphogenesis|vascular endothelial growth factor binding|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|neuron projection guidance|regulation of endothelial cell migration|regulation of protein metabolic process|otic vesicle development|positive regulation of cell morphogenesis involved in differentiation|retina vasculature development in camera-type eye|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|blood vessel endothelial cell differentiation|facial nerve morphogenesis|regulation of intracellular signal transduction|circulatory system development|phosphotransferase activity, alcohol group as acceptor|regulation of axon guidance|cytoskeleton|regulation of programmed cell death|neuron projection extension|regulation of nervous system development|cell fate commitment|positive regulation of endothelial cell migration|focal adhesion|apoptotic signaling pathway|positive regulation of axon extension|regulation of protein binding|cranial nerve development|neuron development|positive regulation of retinal ganglion cell axon guidance|neuron differentiation|negative regulation of extrinsic apoptotic signaling pathway|response to hepatocyte growth factor|endothelium development|axon guidance|trigeminal nerve structural organization|otic vesicle morphogenesis|central nervous system neuron differentiation|neural crest cell migration|cerebral cortex tangential migration|stem cell differentiation|regulation of neuron projection development|protein localization to organelle|positive regulation of protein modification process|epithelial cell differentiation|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|sympathetic neuron projection guidance|camera-type eye development|regulation of neuron apoptotic process|regulation of axon extension involved in axon guidance|trigeminal nerve development|axonal fasciculation|smooth muscle cell migration|mesenchymal cell development|semaphorin-plexin signaling pathway involved in neuron projection guidance|cranial ganglion development|regulation of extrinsic apoptotic signaling pathway|cellular response to growth factor stimulus|phosphorylation|regulation of smooth muscle cell migration|ERK1 and ERK2 cascade|cell migration involved in sprouting angiogenesis|endothelial cell chemotaxis|axon development|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|regulation of endothelial cell proliferation|dorsal root ganglion morphogenesis|sympathetic neuron projection extension|positive regulation of axon extension involved in axon guidance|branching involved in salivary gland morphogenesis|ear morphogenesis|regulation of retinal ganglion cell axon guidance|enzyme linked receptor protein signaling pathway|positive regulation of smooth muscle cell migration|endothelial tip cell fate specification|vestibulocochlear nerve structural organization|positive regulation of protein binding|central nervous system neuron development|neural crest cell migration involved in autonomic nervous system development|sympathetic ganglion development|positive regulation of MAPK cascade|intermediate filament cytoskeleton|vestibulocochlear nerve development|epithelial cell migration|regulation of apoptotic process|dorsal root ganglion development|negative regulation of apoptotic process|positive regulation of endothelial cell proliferation|protein kinase activity|epithelial cell fate commitment|mesenchymal cell differentiation|salivary gland morphogenesis|neuron apoptotic process|forebrain neuron differentiation|negative regulation of neuron differentiation|semaphorin-plexin signaling pathway|negative regulation of neuron apoptotic process|coronary artery morphogenesis|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|regulation of neurogenesis|negative regulation of axon extension involved in axon guidance|facial nerve structural organization|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|positive regulation of neuron projection development|negative regulation of neuron projection development|segmentation|apoptotic process|negative regulation of axonogenesis|axon extension|positive regulation of neuron differentiation|neural crest cell differentiation|neural crest cell development|endothelial cell differentiation|trigeminal ganglion development|vascular endothelial growth factor-activated receptor activity|sensory neuron axon guidance|axonogenesis|protein phosphorylation|motor neuron axon guidance|generation of neurons|VEGF-activated neuropilin signaling pathway involved in axon guidance|cellular response to hepatocyte growth factor stimulus|regulation of phosphorylation|VEGF-activated neuropilin signaling pathway|cellular response to vascular endothelial growth factor stimulus|positive regulation of receptor binding|protein tyrosine kinase activity|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|dichotomous subdivision of terminal units involved in salivary gland branching|semaphorin-plexin signaling pathway involved in axon guidance|commissural neuron axon guidance|forebrain neuron development|positive regulation of protein phosphorylation|facioacoustic ganglion development|protein localization to endosome|regulation of ERK1 and ERK2 cascade|retinal ganglion cell axon guidance|axon extension involved in axon guidance|endothelial cell migration|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|blood vessel endothelial cell fate specification|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of cytokine activity|ventral trunk neural crest cell migration|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|branchiomotor neuron axon guidance|regulation of peptidyl-tyrosine phosphorylation|platelet-derived growth factor receptor signaling pathway|positive regulation of cytokine activity|protein localization to early endosome|vascular endothelial growth factor signaling pathway|hepatocyte growth factor receptor signaling pathway|peptidyl-tyrosine phosphorylation|blood vessel endothelial cell migration K06724 neuropilin 1[-] hsa05166|hsa04360 HTLV-I infection - Homo sapiens (human)|Axon guidance - Homo sapiens (human) 10:33177492-33336262 198 207 234 970 1203 753 0.796469040274419 0.756753025591427 0.84865872488533 3.49601224030959 3.97042353163944 2.83875133694669 0.800626930250392 3.43506236963191 -2.10113424516223 2.58863575171073e-19 1.88951422326582e-17 DOWN ENSG00000156958 GALK2 galactokinase 2 [Source:HGNC Symbol;Acc:HGNC:4119] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0043167|GO:0044237|GO:0005622|GO:0016740|GO:0044262|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0005737|GO:0005975|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0005996|GO:0016301|GO:0006796|GO:0017076|GO:0046835|GO:0016773|GO:0019318|GO:0004335|GO:0019200|GO:0005524|GO:0033858|GO:0030554|GO:0016310|GO:0006012 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|ion binding|cellular metabolic process|intracellular|transferase activity|cellular carbohydrate metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cytoplasm|carbohydrate metabolic process|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|monosaccharide metabolic process|kinase activity|phosphate-containing compound metabolic process|purine nucleotide binding|carbohydrate phosphorylation|phosphotransferase activity, alcohol group as acceptor|hexose metabolic process|galactokinase activity|carbohydrate kinase activity|ATP binding|N-acetylgalactosamine kinase activity|adenyl nucleotide binding|phosphorylation|galactose metabolic process - - - - 15:49155656-49367869 14 22 41 216 255 205 0.0668874876552214 0.0955234800580527 0.176604080057723 0.924612679696878 0.999576501798407 0.9178893829827 0.113005015923666 0.947359521492662 -3.06752521959034 2.71250250265017e-19 1.97509877351508e-17 DOWN ENSG00000132849 INADL InaD-like (Drosophila) [Source:HGNC Symbol;Acc:HGNC:28881] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0045177|GO:0005911|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016324|GO:0031982|GO:0022607|GO:0005737|GO:0007154|GO:0007165|GO:0070062|GO:0043296|GO:0045216|GO:0034329|GO:0048471|GO:0035556|GO:0005923|GO:0007043|GO:0070830|GO:0043297 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|apical part of cell|cell-cell junction|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|apical plasma membrane|vesicle|cellular component assembly|cytoplasm|cell communication|signal transduction|extracellular exosome|apical junction complex|cell-cell junction organization|cell junction assembly|perinuclear region of cytoplasm|intracellular signal transduction|bicellular tight junction|cell-cell junction assembly|bicellular tight junction assembly|apical junction assembly K06092 InaD-like protein[-] hsa04390|hsa04530 Hippo signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human) 1:61742477-62178675 234 270 543 1757 1992 2408 0.943643398965703 0.98954287448542 1.97426492967562 6.34834998659164 6.59095964365181 9.10074121353739 1.30248373437558 7.34668361459361 -2.49582779019458 2.94229872247774e-19 2.13721133968006e-17 DOWN ENSG00000130449 ZSWIM6 zinc finger, SWIM-type containing 6 [Source:HGNC Symbol;Acc:HGNC:29316] GO:0040011|GO:0032502|GO:0009987|GO:0005488|GO:0050794|GO:0040012|GO:0043167|GO:0048870|GO:0009653|GO:0016043|GO:0050793|GO:0048856|GO:0045595|GO:0048468|GO:0007275|GO:0043169|GO:0006928|GO:0051270|GO:0016477|GO:0030030|GO:0048869|GO:2000145|GO:0000902|GO:0031175|GO:0046872|GO:0030334|GO:0001764|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0051960|GO:0048666|GO:0030182|GO:2001222|GO:0046914|GO:0022008|GO:0050767|GO:0048812|GO:0048699|GO:0008270 locomotion|developmental process|cellular process|binding|regulation of cellular process|regulation of locomotion|ion binding|cell motility|anatomical structure morphogenesis|cellular component organization|regulation of developmental process|anatomical structure development|regulation of cell differentiation|cell development|multicellular organism development|cation binding|movement of cell or subcellular component|regulation of cellular component movement|cell migration|cell projection organization|cellular developmental process|regulation of cell motility|cell morphogenesis|neuron projection development|metal ion binding|regulation of cell migration|neuron migration|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron migration|transition metal ion binding|neurogenesis|regulation of neurogenesis|neuron projection morphogenesis|generation of neurons|zinc ion binding - - - - 5:61332273-61546170 53 41 88 368 422 420 0.68152053965188 0.479151028885606 1.02023906180755 4.23984445387577 4.45230030087091 5.06154133724081 0.726970210115012 4.5845620306625 -2.65681576630437 3.20479526424571e-19 2.322231985893e-17 DOWN ENSG00000151532 VTI1A vesicle transport through interaction with t-SNAREs 1A [Source:HGNC Symbol;Acc:HGNC:17792] GO:0032991|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0008021|GO:0043229|GO:0051641|GO:0044297|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0031201|GO:0043025|GO:0006810|GO:0031982|GO:0043231|GO:0030133|GO:0005737|GO:0043005|GO:0005484|GO:0045184|GO:0036477|GO:0000149|GO:0008104|GO:0061024|GO:0051649|GO:0044306|GO:0016021|GO:0010256|GO:0005794|GO:0005768|GO:0006996|GO:0061025|GO:0016192|GO:0016050|GO:0007030|GO:0031410|GO:0015031|GO:0016023|GO:0070382|GO:0046907|GO:0048471|GO:0031988|GO:0034613|GO:0000139|GO:0050881|GO:0048284|GO:0042147|GO:0050882|GO:0048193|GO:0016482|GO:0006886|GO:0090161|GO:0006906|GO:0030135|GO:0016197|GO:0048280|GO:0030136|GO:0006888 macromolecular complex|synapse|cell|membrane|cellular process|binding|cell projection|synaptic vesicle|intracellular organelle|cellular localization|cell body|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|SNARE complex|neuronal cell body|transport|vesicle|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|neuron projection|SNAP receptor activity|establishment of protein localization|somatodendritic compartment|SNARE binding|protein localization|membrane organization|establishment of localization in cell|neuron projection terminus|integral component of membrane|endomembrane system organization|Golgi apparatus|endosome|organelle organization|membrane fusion|vesicle-mediated transport|vesicle organization|Golgi organization|cytoplasmic vesicle|protein transport|cytoplasmic, membrane-bounded vesicle|exocytic vesicle|intracellular transport|perinuclear region of cytoplasm|membrane-bounded vesicle|cellular protein localization|Golgi membrane|musculoskeletal movement|organelle fusion|retrograde transport, endosome to Golgi|voluntary musculoskeletal movement|Golgi vesicle transport|cytosolic transport|intracellular protein transport|Golgi ribbon formation|vesicle fusion|coated vesicle|endosomal transport|vesicle fusion with Golgi apparatus|clathrin-coated vesicle|ER to Golgi vesicle-mediated transport K08493 vesicle transport through interaction with t-SNAREs 1[-] hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) 10:112446998-112818744 90 93 143 599 579 492 0.57597807917583 0.540916449652703 0.825117869925988 3.43471278443491 3.04026765892579 2.95093428909442 0.647337466251507 3.14197157748504 -2.27908021902729 3.22720426738953e-19 2.33280765614157e-17 DOWN ENSG00000057935 MTA3 metastasis associated 1 family member 3 [Source:HGNC Symbol;Acc:HGNC:23784] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0070603|GO:0043231|GO:0043169|GO:0005737|GO:0017053|GO:0009890|GO:0045787|GO:0003682|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0008278|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0090068|GO:0046872|GO:1903047|GO:0010629|GO:0051252|GO:0006325|GO:0044770|GO:0000278|GO:0031981|GO:0007346|GO:0010564|GO:0005654|GO:0005694|GO:0010467|GO:0000118|GO:0009059|GO:0016070|GO:0045931|GO:0005634|GO:0045892|GO:0000086|GO:0032774|GO:0000793|GO:0044772|GO:0043565|GO:2001141|GO:1902679|GO:1901990|GO:1901989|GO:1901992|GO:0046914|GO:1901987|GO:0016581|GO:0006351|GO:0006355|GO:1903507|GO:0010389|GO:1903506|GO:1902751|GO:0010971|GO:1902749|GO:0008270 macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|cation binding|cytoplasm|transcriptional repressor complex|negative regulation of biosynthetic process|positive regulation of cell cycle|chromatin binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cohesin complex|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|metal ion binding|mitotic cell cycle process|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|cell cycle phase transition|mitotic cell cycle|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|chromosome|gene expression|histone deacetylase complex|macromolecule biosynthetic process|RNA metabolic process|positive regulation of mitotic cell cycle|nucleus|negative regulation of transcription, DNA-templated|G2/M transition of mitotic cell cycle|RNA biosynthetic process|condensed chromosome|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of mitotic cell cycle phase transition|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|transition metal ion binding|regulation of cell cycle phase transition|NuRD complex|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of G2/M transition of mitotic cell cycle|regulation of nucleic acid-templated transcription|positive regulation of cell cycle G2/M phase transition|positive regulation of G2/M transition of mitotic cell cycle|regulation of cell cycle G2/M phase transition|zinc ion binding - - - - 2:42494569-42756947 294 330 484 1377 1610 1603 1.37036514371336 1.39791840314265 2.03398630641569 5.75069297976827 6.15718635968949 7.00246293531287 1.60075661775723 6.30344742492354 -1.97738709600176 3.39053333982251e-19 2.44495126393867e-17 DOWN ENSG00000151746 BICD1 bicaudal D homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:1049] GO:0032502|GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0060090|GO:0005200|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0044216|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0019222|GO:0016032|GO:0006725|GO:0051640|GO:0006810|GO:0051130|GO:1901360|GO:0060627|GO:0003676|GO:0005102|GO:0034641|GO:0005874|GO:0031982|GO:0046483|GO:0051128|GO:0022607|GO:0045807|GO:0043231|GO:0019899|GO:0005737|GO:0045502|GO:0006928|GO:0051656|GO:0009966|GO:0045298|GO:0043657|GO:0030674|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0044092|GO:0010970|GO:0007165|GO:0009968|GO:0051649|GO:0008092|GO:0006403|GO:0050790|GO:0043086|GO:0044249|GO:0022613|GO:0010469|GO:0007017|GO:0031323|GO:0005794|GO:0006996|GO:0016192|GO:0005829|GO:0003677|GO:0007186|GO:0010468|GO:0034645|GO:0005802|GO:1900276|GO:0007010|GO:0031410|GO:0008277|GO:0051252|GO:0048260|GO:0046907|GO:0022618|GO:0007018|GO:0045744|GO:0030100|GO:0048471|GO:0051346|GO:0001664|GO:0034613|GO:0070925|GO:0008093|GO:0010467|GO:0009059|GO:0051020|GO:0005881|GO:0008298|GO:0016070|GO:0000226|GO:0072384|GO:0005856|GO:0034452|GO:0034453|GO:0072517|GO:1900737|GO:0007200|GO:0033365|GO:0034622|GO:0006396|GO:0048259|GO:0032774|GO:0043565|GO:2001141|GO:0034063|GO:0031871|GO:0072385|GO:0015630|GO:0031267|GO:0060192|GO:0006897|GO:0030705|GO:0006351|GO:0006355|GO:0010519|GO:0017016|GO:0010517|GO:1903506|GO:0072393|GO:0006898|GO:0017137|GO:1900275 developmental process|macromolecular complex|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|binding, bridging|structural constituent of cytoskeleton|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|other organism cell|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|organelle localization|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of vesicle-mediated transport|nucleic acid binding|receptor binding|cellular nitrogen compound metabolic process|microtubule|vesicle|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of endocytosis|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|dynein binding|movement of cell or subcellular component|establishment of organelle localization|regulation of signal transduction|tubulin complex|host cell|protein binding, bridging|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|negative regulation of molecular function|establishment of localization by movement along microtubule|signal transduction|negative regulation of signal transduction|establishment of localization in cell|cytoskeletal protein binding|RNA localization|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of receptor activity|microtubule-based process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|vesicle-mediated transport|cytosol|DNA binding|G-protein coupled receptor signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|trans-Golgi network|regulation of proteinase activated receptor activity|cytoskeleton organization|cytoplasmic vesicle|regulation of G-protein coupled receptor protein signaling pathway|regulation of RNA metabolic process|positive regulation of receptor-mediated endocytosis|intracellular transport|ribonucleoprotein complex assembly|microtubule-based movement|negative regulation of G-protein coupled receptor protein signaling pathway|regulation of endocytosis|perinuclear region of cytoplasm|negative regulation of hydrolase activity|G-protein coupled receptor binding|cellular protein localization|organelle assembly|cytoskeletal adaptor activity|gene expression|macromolecule biosynthetic process|GTPase binding|cytoplasmic microtubule|intracellular mRNA localization|RNA metabolic process|microtubule cytoskeleton organization|organelle transport along microtubule|cytoskeleton|dynactin binding|microtubule anchoring|host cell viral assembly compartment|negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|protein localization to organelle|cellular macromolecular complex assembly|RNA processing|regulation of receptor-mediated endocytosis|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|stress granule assembly|proteinase activated receptor binding|minus-end-directed organelle transport along microtubule|microtubule cytoskeleton|small GTPase binding|negative regulation of lipase activity|endocytosis|cytoskeleton-dependent intracellular transport|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of phospholipase activity|Ras GTPase binding|regulation of phospholipase activity|regulation of nucleic acid-templated transcription|microtubule anchoring at microtubule organizing center|receptor-mediated endocytosis|Rab GTPase binding|negative regulation of phospholipase C activity - - - - 12:32106835-32383633 41 64 114 454 558 582 0.164973932494142 0.234037959787284 0.413566421078733 1.63674319171344 1.84216574214879 2.19471953729293 0.27085943778672 1.89120949038505 -2.80369291446278 3.70637634122285e-19 2.66626889857511e-17 DOWN ENSG00000083307 GRHL2 grainyhead-like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2799] GO:0032502|GO:0040007|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0030054|GO:0001071|GO:0005488|GO:0032259|GO:0097159|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0044237|GO:0003006|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0001890|GO:0045595|GO:0060670|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0060713|GO:0035295|GO:1901360|GO:0007275|GO:0030324|GO:0003676|GO:0045596|GO:0048513|GO:0060706|GO:0034641|GO:0060672|GO:0031325|GO:0046483|GO:0007420|GO:0022607|GO:0043231|GO:0048608|GO:0000981|GO:0001763|GO:0060322|GO:0060669|GO:0007423|GO:0009887|GO:0035264|GO:0021915|GO:0060463|GO:0048729|GO:0048598|GO:0048568|GO:0003682|GO:0030323|GO:0006139|GO:0001892|GO:0043085|GO:0035148|GO:0060462|GO:0050790|GO:0060324|GO:0048869|GO:0044249|GO:0031323|GO:0060711|GO:0003205|GO:0060425|GO:0000902|GO:0060479|GO:0003677|GO:0048705|GO:0045682|GO:0010468|GO:0090132|GO:0034645|GO:0045216|GO:0042733|GO:0001654|GO:0002009|GO:0003208|GO:0043412|GO:0061458|GO:0072358|GO:0007417|GO:0045605|GO:0002064|GO:0051252|GO:0060541|GO:0003007|GO:0061138|GO:0000904|GO:0009790|GO:0010628|GO:0072175|GO:0051347|GO:0006306|GO:0030856|GO:0034329|GO:0031981|GO:0016331|GO:0003231|GO:0005654|GO:0006259|GO:0043588|GO:0001841|GO:0060429|GO:0051054|GO:0035108|GO:0010467|GO:0048562|GO:0007399|GO:0060562|GO:0048701|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0060606|GO:0001228|GO:0060173|GO:0016070|GO:0072359|GO:0060428|GO:0010557|GO:0030857|GO:0005634|GO:0031490|GO:0044030|GO:0048706|GO:0000975|GO:0045893|GO:0009792|GO:0006260|GO:0043566|GO:0030855|GO:0001843|GO:0043010|GO:0060487|GO:0051972|GO:0032774|GO:0043565|GO:0030216|GO:2001141|GO:0001838|GO:0051973|GO:0008544|GO:0045604|GO:0006304|GO:0003382|GO:2000278|GO:0045617|GO:0006275|GO:0048704|GO:2000573|GO:0045740|GO:0030326|GO:0007043|GO:0071897|GO:0006351|GO:0006355|GO:0070830|GO:0045616|GO:0045944|GO:0006366|GO:0043297|GO:0006357|GO:1903506|GO:0044212|GO:0043009|GO:0009913|GO:0044213|GO:0001701|GO:0001161 developmental process|growth|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|cell junction|nucleic acid binding transcription factor activity|binding|methylation|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|cellular metabolic process|developmental process involved in reproduction|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|placenta development|regulation of cell differentiation|branching involved in labyrinthine layer morphogenesis|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|labyrinthine layer morphogenesis|tube development|organic cyclic compound metabolic process|multicellular organism development|lung development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cell differentiation involved in embryonic placenta development|cellular nitrogen compound metabolic process|epithelial cell morphogenesis involved in placental branching|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|cellular component assembly|intracellular membrane-bounded organelle|reproductive structure development|RNA polymerase II transcription factor activity, sequence-specific DNA binding|morphogenesis of a branching structure|head development|embryonic placenta morphogenesis|sensory organ development|organ morphogenesis|multicellular organism growth|neural tube development|lung lobe morphogenesis|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|chromatin binding|respiratory tube development|nucleobase-containing compound metabolic process|embryonic placenta development|positive regulation of catalytic activity|tube formation|lung lobe development|regulation of catalytic activity|face development|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|labyrinthine layer development|cardiac chamber development|lung morphogenesis|cell morphogenesis|lung cell differentiation|DNA binding|skeletal system morphogenesis|regulation of epidermis development|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|cell-cell junction organization|embryonic digit morphogenesis|eye development|morphogenesis of an epithelium|cardiac ventricle morphogenesis|macromolecule modification|reproductive system development|cardiovascular system development|central nervous system development|negative regulation of epidermal cell differentiation|epithelial cell development|regulation of RNA metabolic process|respiratory system development|heart morphogenesis|morphogenesis of a branching epithelium|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|epithelial tube formation|positive regulation of transferase activity|DNA methylation|regulation of epithelial cell differentiation|cell junction assembly|nuclear lumen|morphogenesis of embryonic epithelium|cardiac ventricle development|nucleoplasm|DNA metabolic process|skin development|neural tube formation|epithelium development|positive regulation of DNA metabolic process|limb morphogenesis|gene expression|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|embryonic cranial skeleton morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|tube closure|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|limb development|RNA metabolic process|circulatory system development|lung epithelium development|positive regulation of macromolecule biosynthetic process|negative regulation of epithelial cell differentiation|nucleus|chromatin DNA binding|regulation of DNA methylation|embryonic skeletal system development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|DNA replication|structure-specific DNA binding|epithelial cell differentiation|neural tube closure|camera-type eye development|lung epithelial cell differentiation|regulation of telomerase activity|RNA biosynthetic process|sequence-specific DNA binding|keratinocyte differentiation|regulation of RNA biosynthetic process|embryonic epithelial tube formation|positive regulation of telomerase activity|epidermis development|regulation of epidermal cell differentiation|DNA modification|epithelial cell morphogenesis|regulation of DNA biosynthetic process|negative regulation of keratinocyte differentiation|regulation of DNA replication|embryonic skeletal system morphogenesis|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|embryonic limb morphogenesis|cell-cell junction assembly|DNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|bicellular tight junction assembly|regulation of keratinocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|apical junction assembly|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|epidermal cell differentiation|intronic transcription regulatory region DNA binding|in utero embryonic development|intronic transcription regulatory region sequence-specific DNA binding - - - - 8:101492432-101669726 355 376 449 1833 1732 1318 3.43335717982011 3.30490653965626 3.91517333066125 15.8836696142039 13.7437918414609 11.9463512470461 3.55114568337921 13.8579375675703 -1.96435610948647 4.61739276890403e-19 3.30934670149301e-17 DOWN ENSG00000177058 SLC38A9 solute carrier family 38 member 9 [Source:HGNC Symbol;Acc:HGNC:26907] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0022857|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0071986|GO:0006810|GO:0043231|GO:0010243|GO:0005774|GO:0005737|GO:0009966|GO:0022891|GO:0010646|GO:0007154|GO:0055085|GO:0007165|GO:0005783|GO:0010008|GO:0016021|GO:0009967|GO:0010033|GO:0098857|GO:0005768|GO:1902533|GO:0005773|GO:1903825|GO:0071417|GO:0043200|GO:0006811|GO:0015075|GO:0005770|GO:0035556|GO:0071310|GO:0045121|GO:1902531|GO:0031902|GO:0034220|GO:0032006|GO:0006820|GO:0015711|GO:0098656|GO:0031929|GO:0000323|GO:0008509|GO:0032008|GO:0046942|GO:0046943|GO:0006865|GO:0071230|GO:0005765|GO:0015171|GO:0005764|GO:0003333|GO:0008514 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|transmembrane transporter activity|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|Ragulator complex|transport|intracellular membrane-bounded organelle|response to organonitrogen compound|vacuolar membrane|cytoplasm|regulation of signal transduction|substrate-specific transmembrane transporter activity|regulation of cell communication|cell communication|transmembrane transport|signal transduction|endoplasmic reticulum|endosome membrane|integral component of membrane|positive regulation of signal transduction|response to organic substance|membrane microdomain|endosome|positive regulation of intracellular signal transduction|vacuole|organic acid transmembrane transport|cellular response to organonitrogen compound|response to amino acid|ion transport|ion transmembrane transporter activity|late endosome|intracellular signal transduction|cellular response to organic substance|membrane raft|regulation of intracellular signal transduction|late endosome membrane|ion transmembrane transport|regulation of TOR signaling|anion transport|organic anion transport|anion transmembrane transport|TOR signaling|lytic vacuole|anion transmembrane transporter activity|positive regulation of TOR signaling|carboxylic acid transport|carboxylic acid transmembrane transporter activity|amino acid transport|cellular response to amino acid stimulus|lysosomal membrane|amino acid transmembrane transporter activity|lysosome|amino acid transmembrane transport|organic anion transmembrane transporter activity - - - - 5:55625845-55773194 67 100 74 451 485 413 0.32930660303281 0.44668775763667 0.327921230617657 1.98608745785129 1.95584477602028 1.90240884948355 0.367971863762379 1.94811369445171 -2.40441051463669 4.6224880234561e-19 3.30934670149301e-17 DOWN ENSG00000137601 NEK1 NIMA-related kinase 1 [Source:HGNC Symbol;Acc:HGNC:7744] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0051726|GO:0007049|GO:0022402|GO:0010941|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0033554|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0000166|GO:0030030|GO:0051301|GO:0048869|GO:0019538|GO:0023014|GO:0031323|GO:0006996|GO:0032268|GO:0000902|GO:0005813|GO:0046872|GO:0035639|GO:1903047|GO:0043412|GO:0005815|GO:0001883|GO:0051347|GO:0036211|GO:0044782|GO:0000278|GO:0032549|GO:0031098|GO:0007346|GO:0030031|GO:0051247|GO:0016301|GO:0070925|GO:0032270|GO:0012501|GO:0006796|GO:0042384|GO:0035556|GO:0044267|GO:0051174|GO:0007067|GO:0032990|GO:0017076|GO:0051246|GO:0048858|GO:0016773|GO:0005856|GO:0005634|GO:0043067|GO:0060271|GO:0031401|GO:0005524|GO:0030554|GO:0016310|GO:0015630|GO:0042981|GO:0004672|GO:0006464|GO:0000242|GO:0043549|GO:0006915|GO:0033674|GO:0045859|GO:0045860|GO:0006468|GO:0042325|GO:0004713|GO:0001932|GO:0018193|GO:0004674|GO:0001934|GO:0042327|GO:0032147|GO:0018108 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cell cycle|cell cycle|cell cycle process|regulation of cell death|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|nucleotide binding|cell projection organization|cell division|cellular developmental process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cell morphogenesis|centrosome|metal ion binding|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|microtubule organizing center|purine nucleoside binding|positive regulation of transferase activity|protein modification process|cilium organization|mitotic cell cycle|ribonucleoside binding|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|cell projection assembly|positive regulation of protein metabolic process|kinase activity|organelle assembly|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|cilium assembly|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|cell part morphogenesis|purine nucleotide binding|regulation of protein metabolic process|cell projection morphogenesis|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|regulation of programmed cell death|cilium morphogenesis|positive regulation of protein modification process|ATP binding|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|regulation of apoptotic process|protein kinase activity|cellular protein modification process|pericentriolar material|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|protein tyrosine kinase activity|regulation of protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|positive regulation of phosphorylation|activation of protein kinase activity|peptidyl-tyrosine phosphorylation - - - - 4:169393275-169612629 34 38 80 370 409 333 0.168990560858306 0.171649626124553 0.358495690207252 1.64770559626084 1.66790547530831 1.55114554272385 0.233045292396704 1.62225220476433 -2.79931585145802 5.29200191863916e-19 3.77960347557544e-17 DOWN ENSG00000033627 ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 [Source:HGNC Symbol;Acc:HGNC:865] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0022857|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0016817|GO:0022607|GO:0043231|GO:0019899|GO:0033177|GO:0010243|GO:0005774|GO:0005737|GO:0012506|GO:0042592|GO:0030666|GO:0045184|GO:0019725|GO:0022891|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0070062|GO:0009725|GO:0016469|GO:0010008|GO:0016021|GO:0044249|GO:0010033|GO:0005794|GO:0005768|GO:0006996|GO:0016820|GO:1901998|GO:0007166|GO:0031410|GO:0019693|GO:0048878|GO:0016471|GO:0051117|GO:0015031|GO:1901652|GO:0005773|GO:0071417|GO:0016023|GO:0016818|GO:0009116|GO:0006811|GO:0033176|GO:0055082|GO:0015075|GO:0090382|GO:0031981|GO:0043434|GO:0031988|GO:0005654|GO:0006461|GO:0006796|GO:0030659|GO:1901137|GO:0071310|GO:0033179|GO:0000220|GO:0090662|GO:0032870|GO:0005634|GO:0030670|GO:0034220|GO:0033572|GO:0009142|GO:0098655|GO:0009124|GO:0034622|GO:0030139|GO:0009259|GO:1901653|GO:0009117|GO:0015992|GO:0046390|GO:0006812|GO:0043623|GO:0015991|GO:0007167|GO:0042625|GO:0071375|GO:0006163|GO:0050801|GO:0032868|GO:0042626|GO:0009165|GO:0016462|GO:0042278|GO:0006873|GO:0008324|GO:0019829|GO:0006164|GO:1902600|GO:0017111|GO:0045335|GO:0042470|GO:0032869|GO:0022890|GO:0030001|GO:0030003|GO:0015672|GO:0009156|GO:0007169|GO:0016887|GO:0046034|GO:0055065|GO:0009152|GO:0046961|GO:0006875|GO:0009168|GO:0015077|GO:0008286|GO:0042623|GO:0015078|GO:0006885|GO:0030641|GO:0006754|GO:0015986|GO:0006826|GO:0070072|GO:0006879|GO:0051453|GO:0055072|GO:0043492|GO:0045851|GO:0051452|GO:0007035 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|transmembrane transporter activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|proton-transporting two-sector ATPase complex, proton-transporting domain|response to organonitrogen compound|vacuolar membrane|cytoplasm|vesicle membrane|homeostatic process|endocytic vesicle membrane|establishment of protein localization|cellular homeostasis|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|transmembrane transport|signal transduction|extracellular exosome|response to hormone|proton-transporting two-sector ATPase complex|endosome membrane|integral component of membrane|cellular biosynthetic process|response to organic substance|Golgi apparatus|endosome|organelle organization|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|toxin transport|cell surface receptor signaling pathway|cytoplasmic vesicle|ribose phosphate metabolic process|chemical homeostasis|vacuolar proton-transporting V-type ATPase complex|ATPase binding|protein transport|response to peptide|vacuole|cellular response to organonitrogen compound|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nucleoside metabolic process|ion transport|proton-transporting V-type ATPase complex|cellular chemical homeostasis|ion transmembrane transporter activity|phagosome maturation|nuclear lumen|response to peptide hormone|membrane-bounded vesicle|nucleoplasm|protein complex assembly|phosphate-containing compound metabolic process|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular response to organic substance|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase, V0 domain|ATP hydrolysis coupled transmembrane transport|cellular response to hormone stimulus|nucleus|phagocytic vesicle membrane|ion transmembrane transport|transferrin transport|nucleoside triphosphate biosynthetic process|cation transmembrane transport|nucleoside monophosphate biosynthetic process|cellular macromolecular complex assembly|endocytic vesicle|ribonucleotide metabolic process|cellular response to peptide|nucleotide metabolic process|proton transport|ribose phosphate biosynthetic process|cation transport|cellular protein complex assembly|ATP hydrolysis coupled proton transport|enzyme linked receptor protein signaling pathway|ATPase coupled ion transmembrane transporter activity|cellular response to peptide hormone stimulus|purine nucleotide metabolic process|ion homeostasis|response to insulin|ATPase activity, coupled to transmembrane movement of substances|nucleotide biosynthetic process|pyrophosphatase activity|purine nucleoside metabolic process|cellular ion homeostasis|cation transmembrane transporter activity|cation-transporting ATPase activity|purine nucleotide biosynthetic process|hydrogen ion transmembrane transport|nucleoside-triphosphatase activity|phagocytic vesicle|melanosome|cellular response to insulin stimulus|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|monovalent inorganic cation transport|ribonucleoside monophosphate biosynthetic process|transmembrane receptor protein tyrosine kinase signaling pathway|ATPase activity|ATP metabolic process|metal ion homeostasis|purine ribonucleotide biosynthetic process|proton-transporting ATPase activity, rotational mechanism|cellular metal ion homeostasis|purine ribonucleoside monophosphate biosynthetic process|monovalent inorganic cation transmembrane transporter activity|insulin receptor signaling pathway|ATPase activity, coupled|hydrogen ion transmembrane transporter activity|regulation of pH|regulation of cellular pH|ATP biosynthetic process|ATP synthesis coupled proton transport|iron ion transport|vacuolar proton-transporting V-type ATPase complex assembly|cellular iron ion homeostasis|regulation of intracellular pH|iron ion homeostasis|ATPase activity, coupled to movement of substances|pH reduction|intracellular pH reduction|vacuolar acidification K02154 V-type H+-transporting ATPase subunit a[-] hsa01100|hsa05152|hsa04145|hsa00190|hsa04142|hsa05323|hsa05120|hsa04721|hsa05110|hsa04966 Metabolic pathways - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human)|Lysosome - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Synaptic vesicle cycle - Homo sapiens (human)|Vibrio cholerae infection - Homo sapiens (human)|Collecting duct acid secretion - Homo sapiens (human) 17:42458844-42522611 103 88 177 612 721 707 0.318357136191555 0.24719403054086 0.493245426716179 1.69482650664782 1.82843272519444 2.04797146169405 0.352932197816198 1.85707689784544 -2.39557059809702 5.61273633763852e-19 3.99910812944774e-17 DOWN ENSG00000185238 PRMT3 protein arginine methyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:30163] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0016570|GO:0034641|GO:0046483|GO:0043169|GO:0005737|GO:0030529|GO:0006139|GO:0016021|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0005829|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0051252|GO:0005840|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0032269|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0034969|GO:0008276|GO:0016568|GO:0006464|GO:0008757|GO:0018216|GO:0006351|GO:0008170|GO:0006355|GO:1903506|GO:0016274|GO:0018193|GO:0042054|GO:0035246|GO:0032446|GO:0008469|GO:0035247|GO:0035242|GO:0031396|GO:0031397|GO:0019919|GO:0016567 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|methylation|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|heterocycle metabolic process|cation binding|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|integral component of membrane|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|cytosol|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|regulation of RNA metabolic process|ribosome|histone methylation|protein methylation|chromatin organization|protein modification process|negative regulation of cellular protein metabolic process|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|histone arginine methylation|protein methyltransferase activity|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|peptidyl-arginine methylation|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|protein-arginine N-methyltransferase activity|peptidyl-amino acid modification|histone methyltransferase activity|peptidyl-arginine N-methylation|protein modification by small protein conjugation|histone-arginine N-methyltransferase activity|peptidyl-arginine omega-N-methylation|protein-arginine omega-N asymmetric methyltransferase activity|regulation of protein ubiquitination|negative regulation of protein ubiquitination|peptidyl-arginine methylation, to asymmetrical-dimethyl arginine|protein ubiquitination - - - - 11:20387530-20509294 180 198 205 1104 1291 684 1.4762478468649 1.4758128477282 1.51584157024704 8.11247407583766 8.68721776464269 5.25741005161064 1.48930075494671 7.35236729736366 -2.30357371363532 5.96193222188568e-19 4.23779820362322e-17 DOWN ENSG00000198363 ASPH aspartate beta-hydroxylase [Source:HGNC Symbol;Acc:HGNC:757] GO:0032502|GO:0009055|GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0051606|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0008307|GO:0005622|GO:0005789|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0060341|GO:0042127|GO:0051282|GO:0006725|GO:0051213|GO:0044325|GO:0006810|GO:1901360|GO:0005938|GO:0033017|GO:0007275|GO:0010524|GO:0060325|GO:0034641|GO:0043270|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0031227|GO:0043169|GO:0010243|GO:0005737|GO:0007389|GO:0003012|GO:0016705|GO:0060322|GO:0032880|GO:0051222|GO:0042592|GO:0009966|GO:0045184|GO:0019725|GO:0032388|GO:0010646|GO:0006139|GO:0010171|GO:0043085|GO:0030176|GO:0008104|GO:1902495|GO:0007154|GO:0055085|GO:0009593|GO:0007165|GO:0005783|GO:0031647|GO:0051649|GO:0060323|GO:2000021|GO:0090316|GO:0008285|GO:0050790|GO:0060324|GO:0051238|GO:0016021|GO:0010035|GO:0009967|GO:0044249|GO:0010469|GO:0019538|GO:0031301|GO:0010033|GO:0031323|GO:0032411|GO:0003013|GO:0060021|GO:0055114|GO:0014701|GO:1902533|GO:0032268|GO:0010468|GO:0006936|GO:0034645|GO:0016528|GO:0005513|GO:0046872|GO:0014074|GO:0043412|GO:0051345|GO:0048878|GO:0051252|GO:0046683|GO:0010644|GO:0032386|GO:0051223|GO:0051604|GO:0015031|GO:0090257|GO:0051208|GO:0010628|GO:0010038|GO:0034767|GO:0036211|GO:0070201|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0051279|GO:0032541|GO:0031585|GO:0051247|GO:0016706|GO:0006508|GO:0034765|GO:0033198|GO:0034702|GO:0043244|GO:0010649|GO:0043269|GO:0034613|GO:0032270|GO:0014070|GO:0035556|GO:0071241|GO:0035108|GO:0044267|GO:0051281|GO:0071782|GO:0010467|GO:0005788|GO:0032414|GO:0031328|GO:0051246|GO:0009059|GO:0010522|GO:0060173|GO:1903827|GO:1902531|GO:0016070|GO:0051928|GO:0008015|GO:0010557|GO:0060314|GO:0016529|GO:0022898|GO:2000273|GO:0034220|GO:0006941|GO:0008016|GO:0050850|GO:0043241|GO:0045893|GO:0098655|GO:0033157|GO:0006937|GO:0016485|GO:0032774|GO:0090280|GO:0033018|GO:0060047|GO:0034703|GO:0030162|GO:0006812|GO:0051592|GO:1901021|GO:2001141|GO:0010880|GO:0045862|GO:0014808|GO:0052547|GO:0060402|GO:0005509|GO:0016482|GO:0006886|GO:0032412|GO:2001259|GO:1901879|GO:0050801|GO:0004597|GO:1904427|GO:0006464|GO:0019932|GO:0010952|GO:0050848|GO:0060316|GO:0006351|GO:0006355|GO:0006873|GO:0090279|GO:0071248|GO:0070296|GO:1903169|GO:0010881|GO:0018126|GO:0010950|GO:0043624|GO:0071277|GO:1903506|GO:0006942|GO:0060048|GO:1901341|GO:0018193|GO:0034704|GO:0055117|GO:1901019|GO:0031638|GO:0030001|GO:0019722|GO:0051924|GO:2001257|GO:0030003|GO:0052548|GO:0070588|GO:0010882|GO:2001056|GO:0055065|GO:0097553|GO:0006875|GO:1901339|GO:2000116|GO:0097202|GO:0032237|GO:0042264|GO:0051261|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|electron carrier activity|macromolecular complex|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|detection of stimulus|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|structural constituent of muscle|intracellular|endoplasmic reticulum membrane|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cellular localization|regulation of cell proliferation|regulation of sequestering of calcium ion|cellular aromatic compound metabolic process|dioxygenase activity|ion channel binding|transport|organic cyclic compound metabolic process|cell cortex|sarcoplasmic reticulum membrane|multicellular organism development|positive regulation of calcium ion transport into cytosol|face morphogenesis|cellular nitrogen compound metabolic process|positive regulation of ion transport|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cation binding|response to organonitrogen compound|cytoplasm|pattern specification process|muscle system process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|head development|regulation of protein localization|positive regulation of protein transport|homeostatic process|regulation of signal transduction|establishment of protein localization|cellular homeostasis|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|body morphogenesis|positive regulation of catalytic activity|integral component of endoplasmic reticulum membrane|protein localization|transmembrane transporter complex|cell communication|transmembrane transport|detection of chemical stimulus|signal transduction|endoplasmic reticulum|regulation of protein stability|establishment of localization in cell|head morphogenesis|regulation of ion homeostasis|positive regulation of intracellular protein transport|negative regulation of cell proliferation|regulation of catalytic activity|face development|sequestering of metal ion|integral component of membrane|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|regulation of receptor activity|protein metabolic process|integral component of organelle membrane|response to organic substance|regulation of cellular metabolic process|positive regulation of transporter activity|circulatory system process|palate development|oxidation-reduction process|junctional sarcoplasmic reticulum membrane|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|sarcoplasm|detection of calcium ion|metal ion binding|response to purine-containing compound|macromolecule modification|positive regulation of hydrolase activity|chemical homeostasis|regulation of RNA metabolic process|response to organophosphorus|cell communication by electrical coupling|regulation of intracellular transport|regulation of protein transport|protein maturation|protein transport|regulation of muscle system process|sequestering of calcium ion|positive regulation of gene expression|response to metal ion|positive regulation of ion transmembrane transport|protein modification process|regulation of establishment of protein localization|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|regulation of release of sequestered calcium ion into cytosol|cortical endoplasmic reticulum|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|positive regulation of protein metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|proteolysis|regulation of ion transmembrane transport|response to ATP|ion channel complex|regulation of protein complex disassembly|regulation of cell communication by electrical coupling|regulation of ion transport|cellular protein localization|positive regulation of cellular protein metabolic process|response to organic cyclic compound|intracellular signal transduction|cellular response to inorganic substance|limb morphogenesis|cellular protein metabolic process|positive regulation of release of sequestered calcium ion into cytosol|endoplasmic reticulum tubular network|gene expression|endoplasmic reticulum lumen|positive regulation of ion transmembrane transporter activity|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|limb development|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of calcium ion transport|blood circulation|positive regulation of macromolecule biosynthetic process|regulation of ryanodine-sensitive calcium-release channel activity|sarcoplasmic reticulum|regulation of transmembrane transporter activity|positive regulation of receptor activity|ion transmembrane transport|striated muscle contraction|regulation of heart contraction|positive regulation of calcium-mediated signaling|protein complex disassembly|positive regulation of transcription, DNA-templated|cation transmembrane transport|regulation of intracellular protein transport|regulation of muscle contraction|protein processing|RNA biosynthetic process|positive regulation of calcium ion import|sarcoplasmic reticulum lumen|heart contraction|cation channel complex|regulation of proteolysis|cation transport|response to calcium ion|positive regulation of calcium ion transmembrane transporter activity|regulation of RNA biosynthetic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|positive regulation of proteolysis|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|regulation of peptidase activity|calcium ion transport into cytosol|calcium ion binding|cytosolic transport|intracellular protein transport|regulation of ion transmembrane transporter activity|positive regulation of cation channel activity|regulation of protein depolymerization|ion homeostasis|peptide-aspartate beta-dioxygenase activity|positive regulation of calcium ion transmembrane transport|cellular protein modification process|second-messenger-mediated signaling|positive regulation of peptidase activity|regulation of calcium-mediated signaling|positive regulation of ryanodine-sensitive calcium-release channel activity|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of calcium ion import|cellular response to metal ion|sarcoplasmic reticulum calcium ion transport|regulation of calcium ion transmembrane transport|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|protein hydroxylation|positive regulation of endopeptidase activity|cellular protein complex disassembly|cellular response to calcium ion|regulation of nucleic acid-templated transcription|regulation of striated muscle contraction|cardiac muscle contraction|positive regulation of store-operated calcium channel activity|peptidyl-amino acid modification|calcium channel complex|regulation of cardiac muscle contraction|regulation of calcium ion transmembrane transporter activity|zymogen activation|metal ion transport|calcium-mediated signaling|regulation of calcium ion transport|regulation of cation channel activity|cellular cation homeostasis|regulation of endopeptidase activity|calcium ion transmembrane transport|regulation of cardiac muscle contraction by calcium ion signaling|positive regulation of cysteine-type endopeptidase activity|metal ion homeostasis|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|regulation of store-operated calcium channel activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|activation of store-operated calcium channel activity|peptidyl-aspartic acid hydroxylation|protein depolymerization|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration - - - - 8:61500556-61714640 2619 2383 5041 15417 18576 19337 5.24889781598174 4.34046901337378 9.10884780272103 27.684082162847 30.545885301695 36.3203980198357 6.23273821069218 31.5167884947926 -2.33818251156986 6.69152293172273e-19 4.74510037063303e-17 DOWN ENSG00000188419 CHM choroideremia (Rab escort protein 1) [Source:HGNC Symbol;Acc:HGNC:1940] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0016491|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006810|GO:0050877|GO:0008047|GO:0019899|GO:0005737|GO:0045184|GO:0043085|GO:0008104|GO:0061024|GO:0051649|GO:0016765|GO:0050790|GO:0019538|GO:0055114|GO:0005829|GO:0090150|GO:0005096|GO:0043412|GO:0004659|GO:0051345|GO:0030695|GO:0015031|GO:0036211|GO:0046907|GO:0007600|GO:0072657|GO:1990234|GO:0034613|GO:0018342|GO:0044267|GO:0051020|GO:0005968|GO:0050953|GO:0008318|GO:0043087|GO:0006605|GO:0018344|GO:0006886|GO:0043547|GO:0031267|GO:0006464|GO:0006612|GO:0017016|GO:0007601|GO:0004661|GO:0017137|GO:0004663 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|oxidoreductase activity|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|transport|neurological system process|enzyme activator activity|enzyme binding|cytoplasm|establishment of protein localization|positive regulation of catalytic activity|protein localization|membrane organization|establishment of localization in cell|transferase activity, transferring alkyl or aryl (other than methyl) groups|regulation of catalytic activity|protein metabolic process|oxidation-reduction process|cytosol|establishment of protein localization to membrane|GTPase activator activity|macromolecule modification|prenyltransferase activity|positive regulation of hydrolase activity|GTPase regulator activity|protein transport|protein modification process|intracellular transport|sensory perception|protein localization to membrane|transferase complex|cellular protein localization|protein prenylation|cellular protein metabolic process|GTPase binding|Rab-protein geranylgeranyltransferase complex|sensory perception of light stimulus|protein prenyltransferase activity|regulation of GTPase activity|protein targeting|protein geranylgeranylation|intracellular protein transport|positive regulation of GTPase activity|small GTPase binding|cellular protein modification process|protein targeting to membrane|Ras GTPase binding|visual perception|protein geranylgeranyltransferase activity|Rab GTPase binding|Rab geranylgeranyltransferase activity - - - - X:85861180-86047562 126 131 221 702 793 801 0.81881731714857 0.773694717227007 1.29486287325017 4.08744913285447 4.228228017736 4.87841811105561 0.962458302541916 4.39803175388203 -2.19206207654958 6.71990126981546e-19 4.75393204997798e-17 DOWN ENSG00000173273 TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase [Source:HGNC Symbol;Acc:HGNC:11941] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0006486|GO:0032205|GO:0007049|GO:0006725|GO:0006810|GO:0022402|GO:0051130|GO:1901360|GO:0034641|GO:0032204|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0032206|GO:0051098|GO:0043231|GO:0000723|GO:0043169|GO:0005737|GO:0005975|GO:0005635|GO:0042592|GO:0009966|GO:0045184|GO:0010646|GO:0006139|GO:0043085|GO:0008104|GO:0007154|GO:0044092|GO:0007165|GO:0016757|GO:0006403|GO:0031965|GO:0050790|GO:0051301|GO:0009967|GO:0044249|GO:0007017|GO:0019538|GO:0031324|GO:0031323|GO:0005794|GO:0006996|GO:0051276|GO:0030111|GO:0005829|GO:0005813|GO:0007004|GO:0010468|GO:0034645|GO:0051053|GO:0051101|GO:0046872|GO:0007166|GO:0051100|GO:0010833|GO:1903047|GO:0043412|GO:0007010|GO:0051252|GO:0005815|GO:0015031|GO:0010628|GO:0051347|GO:0009100|GO:0036211|GO:0000278|GO:1904358|GO:0031981|GO:0070085|GO:0006259|GO:0007051|GO:0005694|GO:0000228|GO:0006461|GO:0034613|GO:0070925|GO:0006471|GO:0050658|GO:0051054|GO:0006796|GO:1901137|GO:0033043|GO:0044267|GO:0007067|GO:0010467|GO:0016763|GO:0000139|GO:0031328|GO:1904355|GO:0030177|GO:1904356|GO:0009059|GO:0016233|GO:0016070|GO:0000226|GO:0005856|GO:0010557|GO:0000922|GO:0005634|GO:0005819|GO:1904357|GO:0005643|GO:0010638|GO:2001252|GO:0016055|GO:0009101|GO:0051225|GO:0045893|GO:0043413|GO:0033365|GO:0032200|GO:0006260|GO:0000781|GO:2001251|GO:0051028|GO:0060828|GO:0051972|GO:0032774|GO:2001141|GO:0051973|GO:0016310|GO:0033044|GO:0070213|GO:0032212|GO:0007052|GO:2000278|GO:0015630|GO:0006275|GO:0000784|GO:0046914|GO:2000573|GO:0045740|GO:0006464|GO:0000242|GO:0090263|GO:0071897|GO:0032210|GO:0003950|GO:0006351|GO:0070212|GO:0006355|GO:0043392|GO:0000775|GO:0045944|GO:0006278|GO:0006366|GO:0034502|GO:1904743|GO:0006357|GO:0006468|GO:1903506|GO:0060070|GO:0018193|GO:0008270|GO:0032446|GO:0070198|GO:0018105|GO:0018107|GO:0016567|GO:0000209 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|protein glycosylation|negative regulation of telomere maintenance|cell cycle|cellular aromatic compound metabolic process|transport|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|regulation of telomere maintenance|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of telomere maintenance|regulation of binding|intracellular membrane-bounded organelle|telomere maintenance|cation binding|cytoplasm|carbohydrate metabolic process|nuclear envelope|homeostatic process|regulation of signal transduction|establishment of protein localization|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|cell communication|negative regulation of molecular function|signal transduction|transferase activity, transferring glycosyl groups|RNA localization|nuclear membrane|regulation of catalytic activity|cell division|positive regulation of signal transduction|cellular biosynthetic process|microtubule-based process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|chromosome organization|regulation of Wnt signaling pathway|cytosol|centrosome|telomere maintenance via telomerase|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|regulation of DNA binding|metal ion binding|cell surface receptor signaling pathway|negative regulation of binding|telomere maintenance via telomere lengthening|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|regulation of RNA metabolic process|microtubule organizing center|protein transport|positive regulation of gene expression|positive regulation of transferase activity|glycoprotein metabolic process|protein modification process|mitotic cell cycle|positive regulation of telomere maintenance via telomere lengthening|nuclear lumen|glycosylation|DNA metabolic process|spindle organization|chromosome|nuclear chromosome|protein complex assembly|cellular protein localization|organelle assembly|protein ADP-ribosylation|RNA transport|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|mitotic nuclear division|gene expression|transferase activity, transferring pentosyl groups|Golgi membrane|positive regulation of cellular biosynthetic process|positive regulation of telomere capping|positive regulation of Wnt signaling pathway|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|telomere capping|RNA metabolic process|microtubule cytoskeleton organization|cytoskeleton|positive regulation of macromolecule biosynthetic process|spindle pole|nucleus|spindle|negative regulation of telomere maintenance via telomere lengthening|nuclear pore|positive regulation of organelle organization|positive regulation of chromosome organization|Wnt signaling pathway|glycoprotein biosynthetic process|spindle assembly|positive regulation of transcription, DNA-templated|macromolecule glycosylation|protein localization to organelle|telomere organization|DNA replication|chromosome, telomeric region|negative regulation of chromosome organization|mRNA transport|regulation of canonical Wnt signaling pathway|regulation of telomerase activity|RNA biosynthetic process|regulation of RNA biosynthetic process|positive regulation of telomerase activity|phosphorylation|regulation of chromosome organization|protein auto-ADP-ribosylation|positive regulation of telomere maintenance via telomerase|mitotic spindle organization|regulation of DNA biosynthetic process|microtubule cytoskeleton|regulation of DNA replication|nuclear chromosome, telomeric region|transition metal ion binding|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|cellular protein modification process|pericentriolar material|positive regulation of canonical Wnt signaling pathway|DNA biosynthetic process|regulation of telomere maintenance via telomerase|NAD+ ADP-ribosyltransferase activity|transcription, DNA-templated|protein poly-ADP-ribosylation|regulation of transcription, DNA-templated|negative regulation of DNA binding|chromosome, centromeric region|positive regulation of transcription from RNA polymerase II promoter|RNA-dependent DNA replication|transcription from RNA polymerase II promoter|protein localization to chromosome|negative regulation of telomeric DNA binding|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|peptidyl-amino acid modification|zinc ion binding|protein modification by small protein conjugation|protein localization to chromosome, telomeric region|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein ubiquitination|protein polyubiquitination - - - - 8:9555914-9782346 80 95 257 1036 1248 1236 0.340019832941705 0.366960531284592 0.984829988515056 3.94522136413262 4.35207827552399 4.92335977482535 0.563936784247118 4.40688647149399 -2.96615437626329 7.10755904331866e-19 5.01629001605757e-17 DOWN ENSG00000214944 ARHGEF28 Rho guanine nucleotide exchange factor 28 [Source:HGNC Symbol;Acc:HGNC:30322] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0005622|GO:0005886|GO:0005085|GO:0048856|GO:0019222|GO:0006935|GO:0048468|GO:0007275|GO:0003676|GO:0043169|GO:0005737|GO:0005088|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0030030|GO:0048869|GO:0000902|GO:0005829|GO:0031175|GO:0046872|GO:0003723|GO:0007166|GO:0051345|GO:0000904|GO:0035556|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0005089|GO:1902531|GO:0048666|GO:0030182|GO:0007411|GO:0043087|GO:0061564|GO:0043547|GO:0007167|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0048812|GO:0007265|GO:0046578|GO:0007409|GO:0048699|GO:0007169|GO:0048013|GO:0035023|GO:0007266 locomotion|developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|intracellular|plasma membrane|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|chemotaxis|cell development|multicellular organism development|nucleic acid binding|cation binding|cytoplasm|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cell projection organization|cellular developmental process|cell morphogenesis|cytosol|neuron projection development|metal ion binding|RNA binding|cell surface receptor signaling pathway|positive regulation of hydrolase activity|cell morphogenesis involved in differentiation|intracellular signal transduction|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|regulation of intracellular signal transduction|neuron development|neuron differentiation|axon guidance|regulation of GTPase activity|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|neuron projection morphogenesis|Ras protein signal transduction|regulation of Ras protein signal transduction|axonogenesis|generation of neurons|transmembrane receptor protein tyrosine kinase signaling pathway|ephrin receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction - - - - 5:73626158-73941993 106 135 294 1022 1181 1325 0.367697576365731 0.425599068523551 0.919491960011652 3.17639522091877 3.36127344108048 4.30755263037167 0.570929534966978 3.61507376412364 -2.6626404831207 7.29030918819271e-19 5.13313421000719e-17 DOWN ENSG00000154309 DISP1 dispatched homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:19711] GO:0032502|GO:0004871|GO:0005215|GO:0023052|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0071704|GO:0038023|GO:0023051|GO:0031224|GO:0005515|GO:0048856|GO:0006810|GO:0007275|GO:0015197|GO:0048513|GO:0061061|GO:0004888|GO:0007389|GO:0009966|GO:0007225|GO:0010646|GO:0007154|GO:0007165|GO:0016021|GO:0009967|GO:0019538|GO:0008158|GO:0007166|GO:0009880|GO:0060541|GO:0051604|GO:0045880|GO:0008589|GO:0009790|GO:0042886|GO:0003002|GO:0010467|GO:0007517|GO:0060538|GO:0007224|GO:0015833|GO:0009855|GO:0009953|GO:0060539|GO:0007368 developmental process|signal transducer activity|transporter activity|signaling|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|organic substance metabolic process|signaling receptor activity|regulation of signaling|intrinsic component of membrane|protein binding|anatomical structure development|transport|multicellular organism development|peptide transporter activity|animal organ development|muscle structure development|transmembrane signaling receptor activity|pattern specification process|regulation of signal transduction|patched ligand maturation|regulation of cell communication|cell communication|signal transduction|integral component of membrane|positive regulation of signal transduction|protein metabolic process|hedgehog receptor activity|cell surface receptor signaling pathway|embryonic pattern specification|respiratory system development|protein maturation|positive regulation of smoothened signaling pathway|regulation of smoothened signaling pathway|embryo development|amide transport|regionalization|gene expression|muscle organ development|skeletal muscle organ development|smoothened signaling pathway|peptide transport|determination of bilateral symmetry|dorsal/ventral pattern formation|diaphragm development|determination of left/right symmetry - - - - 1:222872271-223005995 38 44 32 239 261 260 0.435023128973631 0.457783021763887 0.330284983903721 2.45145539511946 2.45151880354208 2.78952578369787 0.407697044880413 2.56416666078647 -2.65292062967091 7.44199898924157e-19 5.22761030176042e-17 DOWN ENSG00000088256 GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) [Source:HGNC Symbol;Acc:HGNC:4379] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042752|GO:0051716|GO:0042995|GO:0097159|GO:0051606|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0007623|GO:0043167|GO:0009628|GO:0043473|GO:0043227|GO:0071944|GO:0009605|GO:0016787|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0031090|GO:0007507|GO:0050817|GO:0042391|GO:0045595|GO:0009888|GO:0009314|GO:0007275|GO:0048513|GO:0005102|GO:0043168|GO:0048066|GO:0001882|GO:0031982|GO:0016817|GO:0009582|GO:0043231|GO:0043169|GO:0005774|GO:0005737|GO:0009611|GO:0032403|GO:0001775|GO:0072372|GO:0009268|GO:0007154|GO:0001750|GO:0007165|GO:0070062|GO:0000166|GO:0048869|GO:0048070|GO:0050878|GO:0009649|GO:0007186|GO:0030168|GO:0046872|GO:0035639|GO:0009583|GO:0072358|GO:0007596|GO:0001883|GO:0005773|GO:0001508|GO:0016818|GO:0031683|GO:0030856|GO:0042060|GO:0032549|GO:0007602|GO:0007599|GO:0071467|GO:0001664|GO:0050931|GO:0060429|GO:0017076|GO:0030154|GO:0001501|GO:0072359|GO:0009416|GO:0031513|GO:0045634|GO:0032561|GO:0007200|GO:0030855|GO:0000323|GO:0031821|GO:0007213|GO:0009584|GO:0030318|GO:0005525|GO:0007603|GO:0019001|GO:0016462|GO:0005765|GO:0007212|GO:0031826|GO:0005764|GO:0017111|GO:0060158|GO:0060563|GO:0003924 developmental process|signal transducer activity|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|regulation of circadian rhythm|cellular response to stimulus|cell projection|organic cyclic compound binding|detection of stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|circadian rhythm|ion binding|response to abiotic stimulus|pigmentation|membrane-bounded organelle|cell periphery|response to external stimulus|hydrolase activity|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|cilium|organelle membrane|heart development|coagulation|regulation of membrane potential|regulation of cell differentiation|tissue development|response to radiation|multicellular organism development|animal organ development|receptor binding|anion binding|developmental pigmentation|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|detection of abiotic stimulus|intracellular membrane-bounded organelle|cation binding|vacuolar membrane|cytoplasm|response to wounding|protein complex binding|cell activation|primary cilium|response to pH|cell communication|photoreceptor outer segment|signal transduction|extracellular exosome|nucleotide binding|cellular developmental process|regulation of developmental pigmentation|regulation of body fluid levels|entrainment of circadian clock|G-protein coupled receptor signaling pathway|platelet activation|metal ion binding|purine ribonucleoside triphosphate binding|detection of light stimulus|cardiovascular system development|blood coagulation|purine nucleoside binding|vacuole|action potential|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|G-protein beta/gamma-subunit complex binding|regulation of epithelial cell differentiation|wound healing|ribonucleoside binding|phototransduction|hemostasis|cellular response to pH|G-protein coupled receptor binding|pigment cell differentiation|epithelium development|purine nucleotide binding|cell differentiation|skeletal system development|circulatory system development|response to light stimulus|nonmotile primary cilium|regulation of melanocyte differentiation|guanyl ribonucleotide binding|phospholipase C-activating G-protein coupled receptor signaling pathway|epithelial cell differentiation|lytic vacuole|G-protein coupled serotonin receptor binding|G-protein coupled acetylcholine receptor signaling pathway|detection of visible light|melanocyte differentiation|GTP binding|phototransduction, visible light|guanyl nucleotide binding|pyrophosphatase activity|lysosomal membrane|dopamine receptor signaling pathway|type 2A serotonin receptor binding|lysosome|nucleoside-triphosphatase activity|phospholipase C-activating dopamine receptor signaling pathway|neuroepithelial cell differentiation|GTPase activity K04635 guanine nucleotide-binding protein subunit alpha-11[-] hsa05200|hsa04020|hsa04022|hsa04270|hsa04725|hsa05142|hsa05146|hsa04912|hsa04540|hsa04911|hsa04925|hsa04730 Pathways in cancer - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Long-term depression - Homo sapiens (human) 19:3094410-3124004 308 327 505 1533 1720 1428 2.56891065938784 2.47871456249423 3.79755711636819 11.456142549034 11.7705017573609 11.1623584164838 2.94839411275009 11.4630009076262 -1.95898348983348 8.82587536602974e-19 6.18515688209981e-17 DOWN ENSG00000149503 INCENP inner centromere protein [Source:HGNC Symbol;Acc:HGNC:6058] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0030496|GO:0051716|GO:0050794|GO:0043229|GO:0000785|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0022402|GO:0005874|GO:0000776|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0007059|GO:0051301|GO:0000792|GO:0006996|GO:0005829|GO:1903047|GO:0000278|GO:0031981|GO:0005721|GO:0005694|GO:0000228|GO:0035556|GO:0007067|GO:0005856|GO:0000910|GO:0005634|GO:0005819|GO:0000777|GO:0000793|GO:0010369|GO:0000794|GO:0015630|GO:0000795|GO:0000801|GO:0007264|GO:0000800|GO:0000775|GO:0000779 macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|midbody|cellular response to stimulus|regulation of cellular process|intracellular organelle|chromatin|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|cell cycle process|microtubule|kinetochore|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|chromosome segregation|cell division|heterochromatin|organelle organization|cytosol|mitotic cell cycle process|mitotic cell cycle|nuclear lumen|pericentric heterochromatin|chromosome|nuclear chromosome|intracellular signal transduction|mitotic nuclear division|cytoskeleton|cytokinesis|nucleus|spindle|condensed chromosome kinetochore|condensed chromosome|chromocenter|condensed nuclear chromosome|microtubule cytoskeleton|synaptonemal complex|central element|small GTPase mediated signal transduction|lateral element|chromosome, centromeric region|condensed chromosome, centromeric region - - - - 11:62123973-62153163 185 194 271 823 1001 848 1.99395682224974 1.90031031591338 2.63346308499315 7.94768832006609 8.85207715818949 8.56580279679188 2.17591007438542 8.45518942501582 -1.95821814189284 8.87470843571688e-19 6.20481371521994e-17 DOWN ENSG00000134504 KCTD1 potassium channel tetramerization domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18249] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0009890|GO:0006139|GO:0008134|GO:0044249|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:0003714|GO:0010629|GO:0051252|GO:0006461|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0051259|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:1903507|GO:1903506|GO:0051260 cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|negative regulation of gene expression|regulation of RNA metabolic process|protein complex assembly|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|protein oligomerization|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|protein homooligomerization - - - - 18:26454910-26657401 50 55 80 359 402 303 0.313658271488653 0.313571482707227 0.452475227299539 2.01782447023902 2.06911692936717 1.78140470490094 0.359901660498473 1.95611536816904 -2.44231679672657 9.00498401042262e-19 6.28118674409245e-17 DOWN ENSG00000119487 MAPKAP1 mitogen-activated protein kinase associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18752] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006950|GO:0043167|GO:0006955|GO:0023051|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0023057|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0016337|GO:0045087|GO:0050867|GO:0007275|GO:0048513|GO:0048857|GO:0070489|GO:0043168|GO:0006952|GO:0030155|GO:0005543|GO:0031982|GO:0007420|GO:0098609|GO:0043231|GO:0019899|GO:0005737|GO:0060322|GO:0002696|GO:0001775|GO:0009966|GO:0030901|GO:0010646|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0009968|GO:0045785|GO:0031295|GO:0031932|GO:0010033|GO:0005794|GO:0071774|GO:0051249|GO:0005829|GO:0007166|GO:0007417|GO:0031410|GO:0035091|GO:0034109|GO:0016023|GO:0021762|GO:0051251|GO:0022407|GO:0031981|GO:0044344|GO:0007159|GO:0070848|GO:0031988|GO:0005654|GO:0002764|GO:0019900|GO:0042110|GO:0035556|GO:0007399|GO:0071310|GO:1902532|GO:0070300|GO:0051020|GO:0022409|GO:1902531|GO:0005634|GO:0050863|GO:0008543|GO:0071363|GO:0002768|GO:0038179|GO:0034112|GO:0070486|GO:0048017|GO:0007167|GO:1901981|GO:0031267|GO:0051056|GO:0019901|GO:0007264|GO:0050870|GO:0051058|GO:1903039|GO:0048011|GO:0007265|GO:0046578|GO:0048015|GO:0017016|GO:1902936|GO:0038093|GO:0005547|GO:0071593|GO:0046580|GO:0007169|GO:0048010|GO:0038095|GO:0080025|GO:0038127|GO:0005546|GO:0043325|GO:0007173 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|response to stress|ion binding|immune response|regulation of signaling|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|negative regulation of signaling|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|single organismal cell-cell adhesion|innate immune response|positive regulation of cell activation|multicellular organism development|animal organ development|neural nucleus development|T cell aggregation|anion binding|defense response|regulation of cell adhesion|phospholipid binding|vesicle|brain development|cell-cell adhesion|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|head development|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|midbrain development|regulation of cell communication|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|negative regulation of signal transduction|positive regulation of cell adhesion|T cell costimulation|TORC2 complex|response to organic substance|Golgi apparatus|response to fibroblast growth factor|regulation of lymphocyte activation|cytosol|cell surface receptor signaling pathway|central nervous system development|cytoplasmic vesicle|phosphatidylinositol binding|homotypic cell-cell adhesion|cytoplasmic, membrane-bounded vesicle|substantia nigra development|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|nuclear lumen|cellular response to fibroblast growth factor stimulus|leukocyte cell-cell adhesion|response to growth factor|membrane-bounded vesicle|nucleoplasm|immune response-regulating signaling pathway|kinase binding|T cell activation|intracellular signal transduction|nervous system development|cellular response to organic substance|negative regulation of intracellular signal transduction|phosphatidic acid binding|GTPase binding|positive regulation of cell-cell adhesion|regulation of intracellular signal transduction|nucleus|regulation of T cell activation|fibroblast growth factor receptor signaling pathway|cellular response to growth factor stimulus|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|phosphatidylinositol phosphate binding|small GTPase binding|regulation of small GTPase mediated signal transduction|protein kinase binding|small GTPase mediated signal transduction|positive regulation of T cell activation|negative regulation of small GTPase mediated signal transduction|positive regulation of leukocyte cell-cell adhesion|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|phosphatidylinositol-mediated signaling|Ras GTPase binding|phosphatidylinositol bisphosphate binding|Fc receptor signaling pathway|phosphatidylinositol-3,4,5-trisphosphate binding|lymphocyte aggregation|negative regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|phosphatidylinositol-3,5-bisphosphate binding|ERBB signaling pathway|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|epidermal growth factor receptor signaling pathway - - - - 9:125437393-125707234 450 575 633 2213 2326 1839 2.5743276237404 2.98950498343088 3.26489869101793 11.343074333226 10.9176523775353 9.85966743909913 2.94291043272974 10.7067980499535 -1.86321155583829 9.48040715790464e-19 6.59739103244953e-17 DOWN ENSG00000115825 PRKD3 protein kinase D3 [Source:HGNC Symbol;Acc:HGNC:9408] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0000166|GO:0019538|GO:0007186|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0031981|GO:0005654|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0016773|GO:0005634|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0007205|GO:0006468|GO:0004674|GO:0004697 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell communication|signal transduction|nucleotide binding|protein metabolic process|G-protein coupled receptor signaling pathway|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|nuclear lumen|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein kinase C-activating G-protein coupled receptor signaling pathway|protein phosphorylation|protein serine/threonine kinase activity|protein kinase C activity K06070 protein kinase D[2.7.11.13] hsa04015|hsa04925 Rap1 signaling pathway - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human) 2:37250502-37324808 158 168 273 790 961 930 0.679583669792123 0.656710856699725 1.05867532109957 3.04446105350153 3.39138389092207 3.74884470654396 0.798323282530473 3.39489655032252 -2.08832262118909 1.0200067829295e-18 7.08169360408775e-17 DOWN ENSG00000166860 ZBTB39 zinc finger and BTB domain containing 39 [Source:HGNC Symbol;Acc:HGNC:29014] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 12:56998834-57006446 740 978 822 230 259 262 8.48383926041351 10.190120305129 8.49663270246738 2.36257425508519 2.43628303942735 2.81508124930707 9.05686408933663 2.53797951460654 1.83533118365719 1.10759663016743e-18 7.67196979049156e-17 UP ENSG00000061936 SFSWAP splicing factor, suppressor of white-apricot family [Source:HGNC Symbol;Acc:HGNC:10790] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0006139|GO:0044249|GO:0022613|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:0003723|GO:0010629|GO:0051252|GO:0022618|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0034622|GO:0006396|GO:0050684|GO:0032774|GO:2001141|GO:0043484|GO:0006376|GO:0016071|GO:0033119|GO:0006351|GO:0000245|GO:0006355|GO:0048025|GO:1903506|GO:0048024|GO:0000395|GO:0006397|GO:0008380|GO:0000375|GO:0000398|GO:0000380|GO:0045292 cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|negative regulation of gene expression|regulation of RNA metabolic process|ribonucleoprotein complex assembly|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular macromolecular complex assembly|RNA processing|regulation of mRNA processing|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of RNA splicing|mRNA splice site selection|mRNA metabolic process|negative regulation of RNA splicing|transcription, DNA-templated|spliceosomal complex assembly|regulation of transcription, DNA-templated|negative regulation of mRNA splicing, via spliceosome|regulation of nucleic acid-templated transcription|regulation of mRNA splicing, via spliceosome|mRNA 5'-splice site recognition|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|alternative mRNA splicing, via spliceosome|mRNA cis splicing, via spliceosome - - - - 12:131711081-131799737 94 115 128 513 605 465 0.385689456025058 0.428832376087637 0.473514524972048 1.8859196820531 2.03672175269499 1.78809454883475 0.429345452361581 1.90357866119428 -2.14850337142263 1.17763783848803e-18 8.13824074773651e-17 DOWN ENSG00000157557 ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 [Source:HGNC Symbol;Acc:HGNC:3489] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0090009|GO:0003676|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0007389|GO:0048598|GO:0009890|GO:0006139|GO:0001704|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051427|GO:0007498|GO:0009798|GO:0051252|GO:0060795|GO:0007398|GO:0009790|GO:0010628|GO:0001705|GO:0007369|GO:0003002|GO:0031981|GO:0005654|GO:0010467|GO:0001227|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0016070|GO:0010557|GO:0005634|GO:0045165|GO:0000975|GO:0045893|GO:0001078|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0035257|GO:1902679|GO:0003690|GO:0009948|GO:0009952|GO:0001702|GO:0010668|GO:0006351|GO:0001712|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0035258|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0035259|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|cell|membrane|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|primitive streak formation|nucleic acid binding|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|embryonic morphogenesis|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|formation of primary germ layer|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|hormone receptor binding|mesoderm development|axis specification|regulation of RNA metabolic process|cell fate commitment involved in formation of primary germ layer|ectoderm development|embryo development|positive regulation of gene expression|ectoderm formation|gastrulation|regionalization|nuclear lumen|nucleoplasm|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|cell fate commitment|regulatory region DNA binding|positive regulation of transcription, DNA-templated|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nuclear hormone receptor binding|negative regulation of RNA biosynthetic process|double-stranded DNA binding|anterior/posterior axis specification|anterior/posterior pattern specification|gastrulation with mouth forming second|ectodermal cell differentiation|transcription, DNA-templated|ectodermal cell fate commitment|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|glucocorticoid receptor binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K02678 c-ets proto-oncogene protein[-] hsa05166|hsa04014|hsa04320 HTLV-I infection - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Dorso-ventral axis formation - Homo sapiens (human) 21:38805307-38824955 1356 1334 1245 388 439 397 19.5155952881562 17.4485010523113 16.1549621385797 5.00324257877829 5.18388036105439 5.35478234022848 17.7063528263491 5.18063509335372 1.77306620115525 1.24206813824978e-18 8.56367256335081e-17 UP ENSG00000136868 SLC31A1 solute carrier family 31 (copper transporter), member 1 [Source:HGNC Symbol;Acc:HGNC:11016] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0022857|GO:0043229|GO:0044297|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0043025|GO:0006810|GO:0005887|GO:0043231|GO:0005737|GO:0042592|GO:0019725|GO:0036477|GO:0022891|GO:0042493|GO:0031226|GO:0055085|GO:0016021|GO:0005768|GO:0098657|GO:0006855|GO:0072719|GO:0072718|GO:0048878|GO:0006811|GO:0055082|GO:0015075|GO:0055037|GO:0005770|GO:0015893|GO:0034220|GO:0098655|GO:0006812|GO:0050801|GO:0006873|GO:0008324|GO:0022890|GO:0030001|GO:0030003|GO:1902861|GO:0055065|GO:0006875|GO:0035434|GO:0046873|GO:0046915|GO:0006825|GO:0006878|GO:0005375|GO:0015677|GO:0055070|GO:0015088 transporter activity|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|transmembrane transporter activity|intracellular organelle|cell body|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|neuronal cell body|transport|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|cellular homeostasis|somatodendritic compartment|substrate-specific transmembrane transporter activity|response to drug|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|endosome|import into cell|drug transmembrane transport|cellular response to cisplatin|response to cisplatin|chemical homeostasis|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|recycling endosome|late endosome|drug transport|ion transmembrane transport|cation transmembrane transport|cation transport|ion homeostasis|cellular ion homeostasis|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|copper ion import into cell|metal ion homeostasis|cellular metal ion homeostasis|copper ion transmembrane transport|metal ion transmembrane transporter activity|transition metal ion transmembrane transporter activity|copper ion transport|cellular copper ion homeostasis|copper ion transmembrane transporter activity|copper ion import|copper ion homeostasis|copper uptake transmembrane transporter activity K14686 solute carrier family 31 (copper transporter), member 1[-] hsa04978 Mineral absorption - Homo sapiens (human) 9:113221562-113264492 149 188 346 1150 1149 1168 2.01950523786038 2.31577175529126 4.22812900089658 13.9654232622729 12.7775202963593 14.8364594582736 2.85446866468274 13.8598010056353 -2.2796124137413 1.26877143808304e-18 8.72762730703478e-17 DOWN ENSG00000111799 COL12A1 collagen, type XII, alpha 1 [Source:HGNC Symbol;Acc:HGNC:2188] GO:0032502|GO:0031012|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0005201|GO:0043229|GO:0005578|GO:0071704|GO:0009056|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0005615|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0009888|GO:0007275|GO:0043062|GO:0005595|GO:0031982|GO:0043231|GO:0005737|GO:0048598|GO:0044236|GO:0001704|GO:0030020|GO:0005783|GO:0070062|GO:0048869|GO:0005581|GO:0030574|GO:0044259|GO:0022617|GO:0007492|GO:0009790|GO:0007369|GO:0001706|GO:0005788|GO:0030198|GO:0030154|GO:0001501|GO:0035987|GO:0030199|GO:0032963 developmental process|extracellular matrix|macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|extracellular matrix structural constituent|intracellular organelle|proteinaceous extracellular matrix|organic substance metabolic process|catabolic process|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|extracellular space|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|tissue development|multicellular organism development|extracellular structure organization|collagen type XII trimer|vesicle|intracellular membrane-bounded organelle|cytoplasm|embryonic morphogenesis|multicellular organism metabolic process|formation of primary germ layer|extracellular matrix structural constituent conferring tensile strength|endoplasmic reticulum|extracellular exosome|cellular developmental process|collagen trimer|collagen catabolic process|multicellular organismal macromolecule metabolic process|extracellular matrix disassembly|endoderm development|embryo development|gastrulation|endoderm formation|endoplasmic reticulum lumen|extracellular matrix organization|cell differentiation|skeletal system development|endodermal cell differentiation|collagen fibril organization|collagen metabolic process K08132 collagen, type XII, alpha[-] hsa04974 Protein digestion and absorption - Homo sapiens (human) 6:75084326-75206051 17 24 45 233 219 281 0.0787442669499872 0.10103432976869 0.187932173225165 0.967013147194168 0.832321618372959 1.2198691312882 0.122570256647947 1.00640129895178 -3.03752485250851 1.35359664146442e-18 9.28971819178822e-17 DOWN ENSG00000153234 NR4A2 nuclear receptor subfamily 4 group A member 2 [Source:HGNC Symbol;Acc:HGNC:7981] GO:0040011|GO:0032502|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0038023|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0009605|GO:0004879|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0007626|GO:0048856|GO:0019222|GO:0042802|GO:0098531|GO:0043576|GO:0007585|GO:0008344|GO:0021986|GO:0009791|GO:0006725|GO:0003707|GO:0048468|GO:0030534|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0030900|GO:0031325|GO:0046483|GO:0033554|GO:0007420|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0000981|GO:0031668|GO:0060322|GO:0006928|GO:0009966|GO:0046983|GO:0009890|GO:0006979|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0033555|GO:0016477|GO:0007165|GO:0009968|GO:0008134|GO:0009725|GO:0008219|GO:0001666|GO:0050790|GO:0030030|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0021536|GO:0000982|GO:0000902|GO:0031175|GO:0003677|GO:0010468|GO:0034645|GO:1901215|GO:0046872|GO:0033993|GO:0042417|GO:0007417|GO:0010629|GO:0051427|GO:0043069|GO:0051866|GO:2001234|GO:0046982|GO:0051252|GO:0009308|GO:0042974|GO:0070997|GO:1901652|GO:0000904|GO:0071417|GO:0010628|GO:0001764|GO:0031981|GO:0043434|GO:0034599|GO:0005654|GO:0018958|GO:1901214|GO:0012501|GO:0014070|GO:0014075|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0009755|GO:0048858|GO:0001228|GO:0048469|GO:0016070|GO:0006584|GO:0032870|GO:0010557|GO:0005634|GO:0042803|GO:0043067|GO:0048545|GO:0030522|GO:0097190|GO:0048666|GO:0030182|GO:0043401|GO:0021953|GO:0000975|GO:0045893|GO:0042551|GO:0045444|GO:0042416|GO:0042423|GO:1901653|GO:0045892|GO:0043523|GO:0032774|GO:0043565|GO:2001141|GO:0035257|GO:0001077|GO:1902679|GO:0071383|GO:0071407|GO:0003690|GO:0061564|GO:0046965|GO:0021954|GO:0071375|GO:0001975|GO:0042981|GO:0046914|GO:0043066|GO:0051402|GO:0043524|GO:0022008|GO:0048667|GO:0048812|GO:0071396|GO:0042053|GO:0006351|GO:0006915|GO:0006355|GO:0009712|GO:0045944|GO:0006366|GO:1903507|GO:0035258|GO:0021955|GO:0006352|GO:0006357|GO:0007409|GO:0048699|GO:1903506|GO:0044212|GO:0000122|GO:0071376|GO:0008270|GO:0071542|GO:0021952|GO:0006367|GO:0001047|GO:0000976|GO:0001012|GO:0035259|GO:0001046|GO:0000977|GO:0000979 locomotion|developmental process|signal transducer activity|behavior|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|signaling receptor activity|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|response to external stimulus|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|locomotory behavior|anatomical structure development|regulation of metabolic process|identical protein binding|transcription factor activity, direct ligand regulated sequence-specific DNA binding|regulation of respiratory gaseous exchange|respiratory gaseous exchange|adult locomotory behavior|habenula development|post-embryonic development|cellular aromatic compound metabolic process|steroid hormone receptor activity|cell development|adult behavior|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|brain development|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cellular response to extracellular stimulus|head development|movement of cell or subcellular component|regulation of signal transduction|protein dimerization activity|negative regulation of biosynthetic process|response to oxidative stress|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|multicellular organismal response to stress|cell migration|signal transduction|negative regulation of signal transduction|transcription factor binding|response to hormone|cell death|response to hypoxia|regulation of catalytic activity|cell projection organization|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|diencephalon development|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|cell morphogenesis|neuron projection development|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of neuron death|metal ion binding|response to lipid|dopamine metabolic process|central nervous system development|negative regulation of gene expression|hormone receptor binding|negative regulation of programmed cell death|general adaptation syndrome|negative regulation of apoptotic signaling pathway|protein heterodimerization activity|regulation of RNA metabolic process|amine metabolic process|retinoic acid receptor binding|neuron death|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of gene expression|neuron migration|nuclear lumen|response to peptide hormone|cellular response to oxidative stress|nucleoplasm|phenol-containing compound metabolic process|regulation of neuron death|programmed cell death|response to organic cyclic compound|response to amine|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|cell projection morphogenesis|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|cell maturation|RNA metabolic process|catecholamine metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|regulation of programmed cell death|response to steroid hormone|intracellular receptor signaling pathway|apoptotic signaling pathway|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|central nervous system neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|neuron maturation|fat cell differentiation|dopamine biosynthetic process|catecholamine biosynthetic process|cellular response to peptide|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nuclear hormone receptor binding|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|axon development|retinoid X receptor binding|central nervous system neuron development|cellular response to peptide hormone stimulus|response to amphetamine|regulation of apoptotic process|transition metal ion binding|negative regulation of apoptotic process|neuron apoptotic process|negative regulation of neuron apoptotic process|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|cellular response to lipid|regulation of dopamine metabolic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|catechol-containing compound metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|steroid hormone receptor binding|central nervous system neuron axonogenesis|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|cellular response to corticotropin-releasing hormone stimulus|zinc ion binding|dopaminergic neuron differentiation|central nervous system projection neuron axonogenesis|transcription initiation from RNA polymerase II promoter|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|glucocorticoid receptor binding|core promoter sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding K08558 nuclear receptor subfamily 4 group A member 2[-] hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human) 2:156324432-156342348 243 252 346 48 56 67 1.70882633047672 1.61053783914162 2.19371759177644 0.30243092640461 0.323108244591842 0.441565669978161 1.83769392046493 0.355701613658204 2.36915707227437 1.35825644096615e-18 9.3003183001384e-17 UP ENSG00000174032 SLC25A30 solute carrier family 25 member 30 [Source:HGNC Symbol;Acc:HGNC:27371] GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0003735|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0006810|GO:0034641|GO:0043231|GO:0005737|GO:0031966|GO:0051649|GO:0016021|GO:0044249|GO:0019538|GO:0005740|GO:0034645|GO:0006518|GO:0046907|GO:0005743|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0043043|GO:0006839|GO:0006412 structural molecule activity|cell|membrane|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|transport|cellular nitrogen compound metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|establishment of localization in cell|integral component of membrane|cellular biosynthetic process|protein metabolic process|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|intracellular transport|mitochondrial inner membrane|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|peptide biosynthetic process|mitochondrial transport|translation - - - - 13:45393316-45418455 940 919 1124 260 366 309 5.08237127844327 4.51579315788722 5.47922200492252 1.25953104134133 1.62363052226107 1.5657596823916 5.02579548041767 1.48297374866467 1.76085890373127 1.37422085233831e-18 9.38809824386912e-17 UP ENSG00000132561 MATN2 matrilin 2 [Source:HGNC Symbol;Acc:HGNC:6908] GO:0040011|GO:0032502|GO:0031012|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0005604|GO:0051716|GO:0005578|GO:0006950|GO:0043167|GO:0048870|GO:0009653|GO:0016043|GO:0009605|GO:0005515|GO:0048856|GO:0006935|GO:0048468|GO:0007275|GO:0016358|GO:0033554|GO:0043169|GO:0009611|GO:0006928|GO:0016477|GO:0030030|GO:0048869|GO:0000902|GO:0031175|GO:0046872|GO:0031102|GO:0048678|GO:0031104|GO:0000904|GO:0001764|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0048666|GO:0008347|GO:0030182|GO:0007411|GO:0005509|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699|GO:0042063 locomotion|developmental process|extracellular matrix|cellular process|extracellular region|response to stimulus|binding|basement membrane|cellular response to stimulus|proteinaceous extracellular matrix|response to stress|ion binding|cell motility|anatomical structure morphogenesis|cellular component organization|response to external stimulus|protein binding|anatomical structure development|chemotaxis|cell development|multicellular organism development|dendrite development|cellular response to stress|cation binding|response to wounding|movement of cell or subcellular component|cell migration|cell projection organization|cellular developmental process|cell morphogenesis|neuron projection development|metal ion binding|neuron projection regeneration|response to axon injury|dendrite regeneration|cell morphogenesis involved in differentiation|neuron migration|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|neuron development|glial cell migration|neuron differentiation|axon guidance|calcium ion binding|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons|gliogenesis - - - - 8:97868840-98036716 171 182 308 990 971 979 0.913112590186597 0.883240656630984 1.48283430423174 4.73653870157537 4.25417386119145 4.89936775630955 1.09306251701644 4.63002677302546 -2.08264461846503 1.51424285173961e-18 1.03185741690876e-16 DOWN ENSG00000150093 ITGB1 integrin subunit beta 1 [Source:HGNC Symbol;Acc:HGNC:6153] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0032991|GO:0000003|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0005604|GO:1903561|GO:0051716|GO:0042995|GO:0033218|GO:0004872|GO:0014823|GO:0050840|GO:0030055|GO:0048523|GO:0031594|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0005578|GO:0051050|GO:0006950|GO:0043209|GO:0016049|GO:0044702|GO:0071704|GO:0050900|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0009986|GO:0019953|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0005911|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0031252|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:1903829|GO:0005515|GO:0035748|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0097060|GO:0048646|GO:0048609|GO:0019222|GO:0016032|GO:0048514|GO:0007507|GO:0060341|GO:0008284|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:0050817|GO:0016337|GO:0042277|GO:0006935|GO:0045595|GO:0009897|GO:0009888|GO:0045123|GO:0048468|GO:0009314|GO:0006810|GO:0022402|GO:0031623|GO:0051130|GO:0009612|GO:0001568|GO:0010941|GO:0009991|GO:0098797|GO:0007275|GO:0060627|GO:0045596|GO:0048513|GO:0050877|GO:0044291|GO:0005102|GO:0016358|GO:0005924|GO:0043062|GO:0030902|GO:0006952|GO:0030155|GO:0001618|GO:0005912|GO:0031982|GO:0031325|GO:0051128|GO:2000147|GO:0007632|GO:0055094|GO:0007420|GO:0022607|GO:0010942|GO:0045807|GO:0098609|GO:0051668|GO:0030141|GO:0061061|GO:0005887|GO:0045597|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0033627|GO:0031668|GO:0009611|GO:0060322|GO:0032880|GO:0001726|GO:0043235|GO:0071559|GO:0006928|GO:0032403|GO:0042592|GO:0001775|GO:0043005|GO:0031589|GO:0009966|GO:0048729|GO:0030027|GO:0046983|GO:0048598|GO:0045184|GO:0050839|GO:0042383|GO:0001968|GO:0043197|GO:0019725|GO:0030056|GO:0036477|GO:0060135|GO:0048871|GO:0019904|GO:0060548|GO:0042493|GO:0044236|GO:0010646|GO:0031226|GO:0043085|GO:0050776|GO:0001525|GO:0008104|GO:0046649|GO:0007154|GO:0001704|GO:0007565|GO:0061024|GO:0051270|GO:0007276|GO:0016477|GO:0007165|GO:0048588|GO:0090004|GO:0043236|GO:0001669|GO:0009968|GO:0070062|GO:0051649|GO:0045785|GO:0008092|GO:0009725|GO:0008219|GO:0007611|GO:0071437|GO:0031256|GO:0008285|GO:0050790|GO:0030030|GO:0031253|GO:0001948|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031323|GO:0010256|GO:0050878|GO:0032154|GO:0005768|GO:0006996|GO:0051701|GO:0007584|GO:0060560|GO:0050768|GO:0000165|GO:0016192|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0030574|GO:0007186|GO:0098742|GO:0031344|GO:0044259|GO:0042113|GO:0002040|GO:0090132|GO:0045216|GO:0034698|GO:0090150|GO:0046872|GO:0010712|GO:0007166|GO:0033993|GO:1903047|GO:0001944|GO:0043412|GO:0007010|GO:0044309|GO:0030097|GO:0072358|GO:0030098|GO:0007417|GO:0031410|GO:0051345|GO:0007612|GO:0008277|GO:0010720|GO:0007498|GO:0008354|GO:0042692|GO:0043069|GO:0046982|GO:0048878|GO:0048813|GO:0001894|GO:0007596|GO:0035051|GO:0048738|GO:0003779|GO:0044770|GO:0010721|GO:0005518|GO:0071402|GO:0015031|GO:0014704|GO:0031346|GO:0000904|GO:0009790|GO:0050901|GO:0030334|GO:0001667|GO:0007009|GO:0016023|GO:0036211|GO:0031670|GO:0000278|GO:0070201|GO:0060537|GO:0007369|GO:0007160|GO:0042060|GO:0046907|GO:0005178|GO:0055082|GO:0033273|GO:0031345|GO:0042805|GO:0034329|GO:0002020|GO:0010710|GO:0055037|GO:0001707|GO:0072657|GO:0050769|GO:0007599|GO:0001708|GO:0030425|GO:0071478|GO:0007159|GO:0030100|GO:0010810|GO:0051247|GO:0048471|GO:0070848|GO:0031988|GO:0030175|GO:0055001|GO:0030036|GO:0034613|GO:0032587|GO:0070925|GO:0019900|GO:0008305|GO:0032270|GO:0012501|GO:0014070|GO:0006796|GO:1903078|GO:0034113|GO:0055098|GO:0010212|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0032594|GO:0071438|GO:0007399|GO:0033631|GO:0019058|GO:0021535|GO:0071310|GO:0050890|GO:0097485|GO:0006968|GO:1902532|GO:0030198|GO:0051246|GO:0071260|GO:0010811|GO:0030154|GO:0048858|GO:0045121|GO:0030239|GO:0030335|GO:0043068|GO:0031669|GO:1903827|GO:1902531|GO:0072359|GO:0031667|GO:0009416|GO:0043067|GO:1990138|GO:0097305|GO:0048332|GO:0051960|GO:0045165|GO:0005925|GO:0008542|GO:0043112|GO:0048666|GO:0030182|GO:0055002|GO:0002521|GO:0007411|GO:0090003|GO:0033280|GO:0010975|GO:0009792|GO:0031401|GO:0043065|GO:0051393|GO:0021943|GO:0034666|GO:0034679|GO:0034665|GO:0043408|GO:0030183|GO:0072659|GO:0090002|GO:0046718|GO:0044772|GO:0008306|GO:0048333|GO:0034681|GO:0043087|GO:0016310|GO:0071404|GO:0007229|GO:0071407|GO:0002042|GO:0061564|GO:0034680|GO:0006886|GO:0043547|GO:0007156|GO:0043410|GO:0034667|GO:0071295|GO:0051146|GO:0010631|GO:0042981|GO:0050801|GO:0043066|GO:1903076|GO:0071479|GO:0045665|GO:0006897|GO:0031032|GO:0051056|GO:0098639|GO:0019901|GO:0014706|GO:0022008|GO:0030260|GO:0048667|GO:0007264|GO:0055007|GO:0006464|GO:0051058|GO:0045214|GO:0050767|GO:0048812|GO:0034678|GO:0071396|GO:0007043|GO:1990778|GO:0010976|GO:0007161|GO:0006915|GO:0034677|GO:0006873|GO:0048675|GO:0032963|GO:0045666|GO:0070830|GO:0007265|GO:0046578|GO:0043297|GO:0007409|GO:0006468|GO:0048699|GO:2000209|GO:0042325|GO:0001932|GO:0042470|GO:0018193|GO:0006898|GO:0000082|GO:0043276|GO:0043009|GO:0001934|GO:0043542|GO:0045664|GO:0030003|GO:0042327|GO:2000811|GO:0046580|GO:0071305|GO:0050731|GO:0035024|GO:0050730|GO:0055065|GO:0006875|GO:0035023|GO:0001701|GO:0007266|GO:0018108|GO:0043534|GO:0006874|GO:0055074 locomotion|developmental process|extracellular matrix|growth|macromolecular complex|reproduction|immune system process|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|basement membrane|extracellular vesicle|cellular response to stimulus|cell projection|amide binding|receptor activity|response to activity|extracellular matrix binding|cell-substrate junction|negative regulation of cellular process|neuromuscular junction|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|proteinaceous extracellular matrix|positive regulation of transport|response to stress|myelin sheath|cell growth|single organism reproductive process|organic substance metabolic process|leukocyte migration|catabolic process|ion binding|immune response|response to abiotic stimulus|cell surface|sexual reproduction|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cell-cell junction|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|cell leading edge|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|positive regulation of cellular protein localization|protein binding|myelin sheath abaxonal region|plasma membrane|protein complex|endomembrane system|anatomical structure development|synaptic membrane|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|viral process|blood vessel morphogenesis|heart development|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|coagulation|single organismal cell-cell adhesion|peptide binding|chemotaxis|regulation of cell differentiation|external side of plasma membrane|tissue development|cellular extravasation|cell development|response to radiation|transport|cell cycle process|receptor internalization|positive regulation of cellular component organization|response to mechanical stimulus|blood vessel development|regulation of cell death|response to extracellular stimulus|plasma membrane protein complex|multicellular organism development|regulation of vesicle-mediated transport|negative regulation of cell differentiation|animal organ development|neurological system process|cell-cell contact zone|receptor binding|dendrite development|cell-substrate adherens junction|extracellular structure organization|hindbrain development|defense response|regulation of cell adhesion|virus receptor activity|adherens junction|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|visual behavior|response to lipoprotein particle|brain development|cellular component assembly|positive regulation of cell death|positive regulation of endocytosis|cell-cell adhesion|localization within membrane|secretory granule|muscle structure development|integral component of plasma membrane|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|cell adhesion mediated by integrin|cellular response to extracellular stimulus|response to wounding|head development|regulation of protein localization|ruffle|receptor complex|response to transforming growth factor beta|movement of cell or subcellular component|protein complex binding|homeostatic process|cell activation|neuron projection|cell-substrate adhesion|regulation of signal transduction|tissue morphogenesis|lamellipodium|protein dimerization activity|embryonic morphogenesis|establishment of protein localization|cell adhesion molecule binding|sarcolemma|fibronectin binding|dendritic spine|cellular homeostasis|hemidesmosome|somatodendritic compartment|maternal process involved in female pregnancy|multicellular organismal homeostasis|protein domain specific binding|negative regulation of cell death|response to drug|multicellular organism metabolic process|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|regulation of immune response|angiogenesis|protein localization|lymphocyte activation|cell communication|formation of primary germ layer|female pregnancy|membrane organization|regulation of cellular component movement|gamete generation|cell migration|signal transduction|developmental cell growth|positive regulation of establishment of protein localization to plasma membrane|laminin binding|acrosomal vesicle|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|positive regulation of cell adhesion|cytoskeletal protein binding|response to hormone|cell death|learning or memory|invadopodium|leading edge membrane|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|cell projection membrane|glycoprotein binding|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|regulation of cellular metabolic process|endomembrane system organization|regulation of body fluid levels|cleavage furrow|endosome|organelle organization|interaction with host|response to nutrient|developmental growth involved in morphogenesis|negative regulation of neurogenesis|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|collagen catabolic process|G-protein coupled receptor signaling pathway|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of cell projection organization|multicellular organismal macromolecule metabolic process|B cell activation|sprouting angiogenesis|epithelium migration|cell-cell junction organization|response to gonadotropin|establishment of protein localization to membrane|metal ion binding|regulation of collagen metabolic process|cell surface receptor signaling pathway|response to lipid|mitotic cell cycle process|vasculature development|macromolecule modification|cytoskeleton organization|neuron spine|hemopoiesis|cardiovascular system development|lymphocyte differentiation|central nervous system development|cytoplasmic vesicle|positive regulation of hydrolase activity|learning|regulation of G-protein coupled receptor protein signaling pathway|positive regulation of cell development|mesoderm development|germ cell migration|muscle cell differentiation|negative regulation of programmed cell death|protein heterodimerization activity|chemical homeostasis|dendrite morphogenesis|tissue homeostasis|blood coagulation|cardiocyte differentiation|cardiac muscle tissue development|actin binding|cell cycle phase transition|negative regulation of cell development|collagen binding|cellular response to lipoprotein particle stimulus|protein transport|intercalated disc|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|embryo development|leukocyte tethering or rolling|regulation of cell migration|ameboidal-type cell migration|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|protein modification process|cellular response to nutrient|mitotic cell cycle|regulation of establishment of protein localization|muscle tissue development|gastrulation|cell-matrix adhesion|wound healing|intracellular transport|integrin binding|cellular chemical homeostasis|response to vitamin|negative regulation of cell projection organization|actinin binding|cell junction assembly|protease binding|regulation of collagen catabolic process|recycling endosome|mesoderm formation|protein localization to membrane|positive regulation of neurogenesis|hemostasis|cell fate specification|dendrite|cellular response to radiation|leukocyte cell-cell adhesion|regulation of endocytosis|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|perinuclear region of cytoplasm|response to growth factor|membrane-bounded vesicle|filopodium|muscle cell development|actin cytoskeleton organization|cellular protein localization|ruffle membrane|organelle assembly|kinase binding|integrin complex|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|positive regulation of protein localization to plasma membrane|heterotypic cell-cell adhesion|response to low-density lipoprotein particle|response to ionizing radiation|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|protein transport within lipid bilayer|invadopodium membrane|nervous system development|cell-cell adhesion mediated by integrin|viral life cycle|cell migration in hindbrain|cellular response to organic substance|cognition|neuron projection guidance|cellular defense response|negative regulation of intracellular signal transduction|extracellular matrix organization|regulation of protein metabolic process|cellular response to mechanical stimulus|positive regulation of cell-substrate adhesion|cell differentiation|cell projection morphogenesis|membrane raft|myofibril assembly|positive regulation of cell migration|positive regulation of programmed cell death|cellular response to nutrient levels|regulation of cellular protein localization|regulation of intracellular signal transduction|circulatory system development|response to nutrient levels|response to light stimulus|regulation of programmed cell death|neuron projection extension|response to alcohol|mesoderm morphogenesis|regulation of nervous system development|cell fate commitment|focal adhesion|visual learning|receptor metabolic process|neuron development|neuron differentiation|striated muscle cell development|leukocyte differentiation|axon guidance|regulation of establishment of protein localization to plasma membrane|response to vitamin D|regulation of neuron projection development|embryo development ending in birth or egg hatching|positive regulation of protein modification process|positive regulation of apoptotic process|alpha-actinin binding|formation of radial glial scaffolds|integrin alpha2-beta1 complex|integrin alpha9-beta1 complex|integrin alpha1-beta1 complex|regulation of MAPK cascade|B cell differentiation|protein localization to plasma membrane|establishment of protein localization to plasma membrane|viral entry into host cell|mitotic cell cycle phase transition|associative learning|mesodermal cell differentiation|integrin alpha11-beta1 complex|regulation of GTPase activity|phosphorylation|cellular response to low-density lipoprotein particle stimulus|integrin-mediated signaling pathway|cellular response to organic cyclic compound|cell migration involved in sprouting angiogenesis|axon development|integrin alpha10-beta1 complex|intracellular protein transport|positive regulation of GTPase activity|homophilic cell adhesion via plasma membrane adhesion molecules|positive regulation of MAPK cascade|integrin alpha3-beta1 complex|cellular response to vitamin|striated muscle cell differentiation|epithelial cell migration|regulation of apoptotic process|ion homeostasis|negative regulation of apoptotic process|regulation of protein localization to plasma membrane|cellular response to ionizing radiation|negative regulation of neuron differentiation|endocytosis|actomyosin structure organization|regulation of small GTPase mediated signal transduction|collagen binding involved in cell-matrix adhesion|protein kinase binding|striated muscle tissue development|neurogenesis|entry into host cell|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cardiac muscle cell differentiation|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|sarcomere organization|regulation of neurogenesis|neuron projection morphogenesis|integrin alpha8-beta1 complex|cellular response to lipid|cell-cell junction assembly|protein localization to cell periphery|positive regulation of neuron projection development|calcium-independent cell-matrix adhesion|apoptotic process|integrin alpha7-beta1 complex|cellular ion homeostasis|axon extension|collagen metabolic process|positive regulation of neuron differentiation|bicellular tight junction assembly|Ras protein signal transduction|regulation of Ras protein signal transduction|apical junction assembly|axonogenesis|protein phosphorylation|generation of neurons|regulation of anoikis|regulation of phosphorylation|regulation of protein phosphorylation|melanosome|peptidyl-amino acid modification|receptor-mediated endocytosis|G1/S transition of mitotic cell cycle|anoikis|chordate embryonic development|positive regulation of protein phosphorylation|endothelial cell migration|regulation of neuron differentiation|cellular cation homeostasis|positive regulation of phosphorylation|negative regulation of anoikis|negative regulation of Ras protein signal transduction|cellular response to vitamin D|positive regulation of peptidyl-tyrosine phosphorylation|negative regulation of Rho protein signal transduction|regulation of peptidyl-tyrosine phosphorylation|metal ion homeostasis|cellular metal ion homeostasis|regulation of Rho protein signal transduction|in utero embryonic development|Rho protein signal transduction|peptidyl-tyrosine phosphorylation|blood vessel endothelial cell migration|cellular calcium ion homeostasis|calcium ion homeostasis K05719 integrin beta 1[-] hsa05200|hsa04151|hsa04810|hsa04015|hsa05205|hsa04510|hsa04360|hsa04145|hsa04514|hsa04611|hsa05145|hsa04670|hsa05414|hsa05222|hsa05410|hsa04512|hsa05100|hsa05133|hsa05412|hsa05140|hsa05131|hsa05130 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Cell adhesion molecules (CAMs) - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human) 10:32900319-33005792 1987 1931 3464 10374 11375 10433 13.2174267708736 11.6737758546147 20.7750076883764 61.8291122853052 62.0823893695215 65.041006033687 15.2220701046216 62.9841692295046 -2.04882469013492 1.51733572058333e-18 1.03185741690876e-16 DOWN ENSG00000168803 ADAL adenosine deaminase-like [Source:HGNC Symbol;Acc:HGNC:31853] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016787|GO:0009058|GO:0019239|GO:0005622|GO:0006725|GO:1901360|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0043169|GO:0005737|GO:0016810|GO:0004000|GO:0006139|GO:0055086|GO:0017144|GO:0044249|GO:0005829|GO:0046872|GO:0009116|GO:0006796|GO:1901137|GO:0019439|GO:0016814|GO:0043101|GO:0009117|GO:0006144|GO:0042278|GO:0046130|GO:0046085|GO:0046103|GO:0006154 cell|cellular process|metabolic process|binding|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|hydrolase activity|biosynthetic process|deaminase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|cation binding|cytoplasm|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|adenosine deaminase activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|drug metabolic process|cellular biosynthetic process|cytosol|metal ion binding|nucleoside metabolic process|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|aromatic compound catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|purine-containing compound salvage|nucleotide metabolic process|purine nucleobase metabolic process|purine nucleoside metabolic process|purine ribonucleoside catabolic process|adenosine metabolic process|inosine biosynthetic process|adenosine catabolic process - - - - 15:43330674-43354555 25 26 37 189 204 185 0.162644942989743 0.153726648952065 0.217028837459904 1.10167979162269 1.08891600740382 1.12796967381465 0.177800143133904 1.10618849094705 -2.63726884640682 1.57731441516332e-18 1.07020783068831e-16 DOWN ENSG00000070882 OSBPL3 oxysterol binding protein like 3 [Source:HGNC Symbol;Acc:HGNC:16370] GO:0005623|GO:0016020|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043227|GO:0008289|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0005496|GO:0043231|GO:0043178|GO:0005737|GO:0005635|GO:0005783|GO:0031965|GO:0010876|GO:0005829|GO:0032934|GO:0006869|GO:0048471|GO:0097038|GO:0005634|GO:0015485 cell|membrane|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|lipid binding|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|transport|steroid binding|intracellular membrane-bounded organelle|alcohol binding|cytoplasm|nuclear envelope|endoplasmic reticulum|nuclear membrane|lipid localization|cytosol|sterol binding|lipid transport|perinuclear region of cytoplasm|perinuclear endoplasmic reticulum|nucleus|cholesterol binding - - - - 7:24796539-24981634 307 323 488 1445 1630 1387 1.90409740199865 1.82067768489236 2.72888105165729 8.03000633788619 8.29480067112621 8.0622440671601 2.15121871284943 8.12901702539083 -1.9179266997227 1.80081236059824e-18 1.21908054905442e-16 DOWN ENSG00000112902 SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A [Source:HGNC Symbol;Acc:HGNC:10736] GO:0040011|GO:0032502|GO:0040007|GO:0045499|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0040013|GO:0048523|GO:0048521|GO:0008283|GO:0050794|GO:0040012|GO:0051050|GO:0016049|GO:0048520|GO:0043167|GO:0051641|GO:0050795|GO:0048870|GO:0023051|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0031224|GO:0050793|GO:0048589|GO:1903829|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0048514|GO:0060341|GO:0008284|GO:0051272|GO:0042127|GO:0006935|GO:0045595|GO:0009888|GO:0048468|GO:0006810|GO:0051130|GO:0001568|GO:0010941|GO:0007275|GO:0010632|GO:0045596|GO:0048513|GO:0032535|GO:0005102|GO:0043168|GO:0030307|GO:0030155|GO:0030900|GO:0045545|GO:0031982|GO:0051128|GO:2000147|GO:0007420|GO:0045597|GO:0030308|GO:0032970|GO:0007267|GO:0060322|GO:0050920|GO:0032880|GO:0051222|GO:0006928|GO:0009966|GO:0050673|GO:0045184|GO:0048639|GO:0008037|GO:0060548|GO:0032388|GO:0010646|GO:0007162|GO:0001525|GO:1900182|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0070062|GO:0048638|GO:0051649|GO:0050922|GO:0008219|GO:0051271|GO:0090316|GO:0010634|GO:0048640|GO:0035373|GO:0030030|GO:0001948|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0009967|GO:0043395|GO:0005539|GO:0001558|GO:0021536|GO:0050921|GO:0006996|GO:0060560|GO:0050768|GO:0050679|GO:1902533|GO:0000902|GO:0042307|GO:0031175|GO:0031344|GO:0002040|GO:0090132|GO:0007166|GO:0032956|GO:0001944|GO:0072594|GO:0007010|GO:0072358|GO:0007417|GO:0010720|GO:0043069|GO:0032386|GO:0010721|GO:0051223|GO:0015031|GO:0031346|GO:0000904|GO:0050919|GO:0030334|GO:0001935|GO:0001667|GO:0030517|GO:0043394|GO:0070201|GO:0046907|GO:0031345|GO:0045766|GO:1990256|GO:0060485|GO:0060326|GO:0050769|GO:0045765|GO:2001028|GO:0008361|GO:0008038|GO:0022604|GO:0050678|GO:0043244|GO:1904591|GO:0030036|GO:0034613|GO:0012501|GO:1901342|GO:0035556|GO:0033043|GO:0048864|GO:0017038|GO:0050918|GO:0030516|GO:0032990|GO:0030215|GO:0007399|GO:0097485|GO:0010594|GO:0010770|GO:0030154|GO:0030832|GO:0048858|GO:0030335|GO:0043243|GO:1903827|GO:1902531|GO:0072359|GO:1902667|GO:0043067|GO:1990138|GO:0006606|GO:0051960|GO:0010595|GO:0045773|GO:0010638|GO:0048666|GO:0030182|GO:0051896|GO:0007411|GO:0043491|GO:1904589|GO:0043241|GO:0001755|GO:0048863|GO:0010975|GO:0033365|GO:0033157|GO:0051169|GO:0010769|GO:0048841|GO:0007413|GO:1901881|GO:0014031|GO:0051897|GO:0006605|GO:0002043|GO:0035767|GO:0008064|GO:0061564|GO:0016482|GO:0001936|GO:0048842|GO:0006886|GO:0051493|GO:0010631|GO:0042981|GO:1901879|GO:0043066|GO:0001938|GO:0048762|GO:0042306|GO:0045665|GO:0071526|GO:1900180|GO:0050772|GO:0022008|GO:0035413|GO:0048667|GO:0007015|GO:0050767|GO:0048843|GO:0051495|GO:0048812|GO:0010976|GO:0035411|GO:0010977|GO:0006915|GO:0050771|GO:0048675|GO:0046824|GO:0045666|GO:0014033|GO:0030836|GO:1903533|GO:0014032|GO:0006913|GO:0007409|GO:0048699|GO:0043624|GO:0035412|GO:0030834|GO:0048846|GO:0043542|GO:0050770|GO:0045664|GO:0034504|GO:0046822|GO:1904036|GO:0008154|GO:0072577|GO:0051170|GO:2000351|GO:2000352|GO:0030042|GO:0051261 locomotion|developmental process|growth|chemorepellent activity|behavior|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|negative regulation of cellular process|negative regulation of behavior|cell proliferation|regulation of cellular process|regulation of locomotion|positive regulation of transport|cell growth|positive regulation of behavior|ion binding|cellular localization|regulation of behavior|cell motility|regulation of signaling|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|intrinsic component of membrane|regulation of developmental process|developmental growth|positive regulation of cellular protein localization|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|chemotaxis|regulation of cell differentiation|tissue development|cell development|transport|positive regulation of cellular component organization|blood vessel development|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|negative regulation of cell differentiation|animal organ development|regulation of cellular component size|receptor binding|anion binding|positive regulation of cell growth|regulation of cell adhesion|forebrain development|syndecan binding|vesicle|regulation of cellular component organization|positive regulation of cell motility|brain development|positive regulation of cell differentiation|negative regulation of cell growth|regulation of actin filament-based process|cell-cell signaling|head development|regulation of chemotaxis|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|regulation of signal transduction|epithelial cell proliferation|establishment of protein localization|positive regulation of developmental growth|cell recognition|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|negative regulation of cell adhesion|angiogenesis|positive regulation of protein localization to nucleus|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|extracellular exosome|regulation of developmental growth|establishment of localization in cell|negative regulation of chemotaxis|cell death|negative regulation of cellular component movement|positive regulation of intracellular protein transport|positive regulation of epithelial cell migration|negative regulation of developmental growth|chondroitin sulfate proteoglycan binding|cell projection organization|glycoprotein binding|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|positive regulation of signal transduction|heparan sulfate proteoglycan binding|glycosaminoglycan binding|regulation of cell growth|diencephalon development|positive regulation of chemotaxis|organelle organization|developmental growth involved in morphogenesis|negative regulation of neurogenesis|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|cell morphogenesis|positive regulation of protein import into nucleus|neuron projection development|regulation of cell projection organization|sprouting angiogenesis|epithelium migration|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|vasculature development|establishment of protein localization to organelle|cytoskeleton organization|cardiovascular system development|central nervous system development|positive regulation of cell development|negative regulation of programmed cell death|regulation of intracellular transport|negative regulation of cell development|regulation of protein transport|protein transport|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|negative chemotaxis|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|negative regulation of axon extension|proteoglycan binding|regulation of establishment of protein localization|intracellular transport|negative regulation of cell projection organization|positive regulation of angiogenesis|signal clustering|mesenchyme development|cell chemotaxis|positive regulation of neurogenesis|regulation of angiogenesis|positive regulation of endothelial cell chemotaxis|regulation of cell size|neuron recognition|regulation of cell morphogenesis|regulation of epithelial cell proliferation|regulation of protein complex disassembly|positive regulation of protein import|actin cytoskeleton organization|cellular protein localization|programmed cell death|regulation of vasculature development|intracellular signal transduction|regulation of organelle organization|stem cell development|protein import|positive chemotaxis|regulation of axon extension|cell part morphogenesis|semaphorin receptor binding|nervous system development|neuron projection guidance|regulation of endothelial cell migration|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|regulation of actin filament length|cell projection morphogenesis|positive regulation of cell migration|positive regulation of protein complex disassembly|regulation of cellular protein localization|regulation of intracellular signal transduction|circulatory system development|regulation of axon guidance|regulation of programmed cell death|neuron projection extension|protein import into nucleus|regulation of nervous system development|positive regulation of endothelial cell migration|positive regulation of axon extension|positive regulation of organelle organization|neuron development|neuron differentiation|regulation of protein kinase B signaling|axon guidance|protein kinase B signaling|regulation of protein import|protein complex disassembly|neural crest cell migration|stem cell differentiation|regulation of neuron projection development|protein localization to organelle|regulation of intracellular protein transport|nuclear transport|regulation of cell morphogenesis involved in differentiation|regulation of axon extension involved in axon guidance|axonal fasciculation|positive regulation of protein depolymerization|mesenchymal cell development|positive regulation of protein kinase B signaling|protein targeting|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell chemotaxis|regulation of actin polymerization or depolymerization|axon development|cytosolic transport|regulation of endothelial cell proliferation|positive regulation of axon extension involved in axon guidance|intracellular protein transport|regulation of cytoskeleton organization|epithelial cell migration|regulation of apoptotic process|regulation of protein depolymerization|negative regulation of apoptotic process|positive regulation of endothelial cell proliferation|mesenchymal cell differentiation|regulation of protein import into nucleus|negative regulation of neuron differentiation|semaphorin-plexin signaling pathway|regulation of protein localization to nucleus|positive regulation of axonogenesis|neurogenesis|positive regulation of catenin import into nucleus|cell morphogenesis involved in neuron differentiation|actin filament organization|regulation of neurogenesis|negative regulation of axon extension involved in axon guidance|positive regulation of cytoskeleton organization|neuron projection morphogenesis|positive regulation of neuron projection development|catenin import into nucleus|negative regulation of neuron projection development|apoptotic process|negative regulation of axonogenesis|axon extension|positive regulation of nucleocytoplasmic transport|positive regulation of neuron differentiation|neural crest cell differentiation|positive regulation of actin filament depolymerization|regulation of protein targeting|neural crest cell development|nucleocytoplasmic transport|axonogenesis|generation of neurons|cellular protein complex disassembly|regulation of catenin import into nucleus|regulation of actin filament depolymerization|axon extension involved in axon guidance|endothelial cell migration|regulation of axonogenesis|regulation of neuron differentiation|protein localization to nucleus|regulation of nucleocytoplasmic transport|negative regulation of epithelial cell apoptotic process|actin polymerization or depolymerization|endothelial cell apoptotic process|nuclear import|regulation of endothelial cell apoptotic process|negative regulation of endothelial cell apoptotic process|actin filament depolymerization|protein depolymerization K06841 semaphorin 5[-] hsa04360 Axon guidance - Homo sapiens (human) 5:9035026-9546075 34 29 83 553 594 1634 0.195900762575174 0.151858123723294 0.431164897356266 2.85480372278706 2.80807022234898 8.82337034129013 0.259641261218245 4.82874809547539 -4.21705762906916 1.8229055971667e-18 1.23124488004106e-16 DOWN ENSG00000178977 LINC00324 long intergenic non-protein coding RNA 324 [Source:HGNC Symbol;Acc:HGNC:26628] - - - - - - 17:8220642-8224043 179 155 169 31 20 27 6.08159029096406 4.78605295240809 5.17684458206185 0.943664867192031 0.55751270871597 0.859715021829776 5.348162608478 0.786964199245926 2.764673419664 1.90702430650362e-18 1.28515358118192e-16 UP ENSG00000114019 AMOTL2 angiomotin like 2 [Source:HGNC Symbol;Acc:HGNC:17812] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0045177|GO:0005911|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0042802|GO:0016324|GO:0031982|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0043296|GO:0005768|GO:0005829|GO:0007166|GO:0031410|GO:0055037|GO:0035556|GO:0005923|GO:0016055|GO:0035329 signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|apical part of cell|cell-cell junction|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|identical protein binding|apical plasma membrane|vesicle|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|apical junction complex|endosome|cytosol|cell surface receptor signaling pathway|cytoplasmic vesicle|recycling endosome|intracellular signal transduction|bicellular tight junction|Wnt signaling pathway|hippo signaling - - - - 3:134355874-134375479 6657 6649 7100 1318 2355 1956 32.2045703590169 29.2331315546596 30.967885478485 5.71283973016538 9.34755216741778 8.8682264620544 30.8018624640538 7.97620611987919 1.94924299026063 1.92930075912776e-18 1.29723749691442e-16 UP ENSG00000066926 FECH ferrochelatase [Source:HGNC Symbol;Acc:HGNC:3647] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0031090|GO:0006725|GO:0019866|GO:0009314|GO:1901360|GO:0051536|GO:0046685|GO:0034641|GO:0044281|GO:0046483|GO:0043231|GO:0043169|GO:0042168|GO:0005737|GO:0031966|GO:0051186|GO:0042493|GO:0004325|GO:0009725|GO:0006091|GO:0010035|GO:0044249|GO:0010033|GO:0009636|GO:0005740|GO:0046872|GO:0051597|GO:0033993|GO:0010038|GO:0006778|GO:0005743|GO:0006783|GO:0005759|GO:0005739|GO:0014070|GO:0071310|GO:0017085|GO:0051537|GO:0032870|GO:0009416|GO:0048545|GO:0097305|GO:0006779|GO:0033014|GO:0070541|GO:0071383|GO:0071407|GO:0045471|GO:0010288|GO:0046914|GO:0046501|GO:0071396|GO:0031960|GO:0071548|GO:0051384|GO:0005506|GO:0071549|GO:0071384|GO:0071385|GO:0008198 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|response to radiation|organic cyclic compound metabolic process|iron-sulfur cluster binding|response to arsenic-containing substance|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|heme metabolic process|cytoplasm|mitochondrial membrane|cofactor metabolic process|response to drug|ferrochelatase activity|response to hormone|generation of precursor metabolites and energy|response to inorganic substance|cellular biosynthetic process|response to organic substance|response to toxic substance|mitochondrial envelope|metal ion binding|response to methylmercury|response to lipid|response to metal ion|porphyrin-containing compound metabolic process|mitochondrial inner membrane|heme biosynthetic process|mitochondrial matrix|mitochondrion|response to organic cyclic compound|cellular response to organic substance|response to insecticide|2 iron, 2 sulfur cluster binding|cellular response to hormone stimulus|response to light stimulus|response to steroid hormone|response to alcohol|porphyrin-containing compound biosynthetic process|tetrapyrrole biosynthetic process|response to platinum ion|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|response to ethanol|response to lead ion|transition metal ion binding|protoporphyrinogen IX metabolic process|cellular response to lipid|response to corticosteroid|response to dexamethasone|response to glucocorticoid|iron ion binding|cellular response to dexamethasone stimulus|cellular response to corticosteroid stimulus|cellular response to glucocorticoid stimulus|ferrous iron binding K01772 ferrochelatase[4.99.1.1] hsa01100|hsa00860 Metabolic pathways - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human) 18:57548283-57586772 161 189 175 785 849 649 1.37046938529137 1.46213363629386 1.34306362597269 5.98703612078773 5.92953162519924 5.17748237544163 1.39188888251931 5.69801670714287 -2.03341580945291 1.99539108279649e-18 1.33866079518666e-16 DOWN ENSG00000120256 LRP11 LDL receptor related protein 11 [Source:HGNC Symbol;Acc:HGNC:16936] GO:0005623|GO:0016020|GO:0050896|GO:0005488|GO:0006950|GO:0009628|GO:0071944|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0051219|GO:0009612|GO:0009991|GO:0009414|GO:0035902|GO:0009408|GO:0033555|GO:0009409|GO:0016021|GO:0010035|GO:0009266|GO:0042594|GO:0031667 cell|membrane|response to stimulus|binding|response to stress|response to abiotic stimulus|cell periphery|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|phosphoprotein binding|response to mechanical stimulus|response to extracellular stimulus|response to water deprivation|response to immobilization stress|response to heat|multicellular organismal response to stress|response to cold|integral component of membrane|response to inorganic substance|response to temperature stimulus|response to starvation|response to nutrient levels - - - - 6:149818798-149864026 106 106 235 817 945 1405 2.00109126694689 1.81864265289068 3.99985991547428 13.8191602158934 14.6373351156117 24.8580672634803 2.60653127843728 17.7715208649951 -2.76936407319971 2.07505785706463e-18 1.38898603732752e-16 DOWN ENSG00000147586 MRPS28 mitochondrial ribosomal protein S28 [Source:HGNC Symbol;Acc:HGNC:14513] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0031090|GO:0019866|GO:0003676|GO:0034641|GO:0005761|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0031966|GO:0044249|GO:0019538|GO:0006996|GO:0005740|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0005840|GO:0005743|GO:0005759|GO:0005739|GO:0070124|GO:0043603|GO:0044267|GO:0010467|GO:0005763|GO:0009059|GO:0015935|GO:0032543|GO:0043241|GO:0043043|GO:0070125|GO:0006412|GO:0044822|GO:0070126|GO:0006414|GO:0043624|GO:0006415 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|organelle membrane|organelle inner membrane|nucleic acid binding|cellular nitrogen compound metabolic process|mitochondrial ribosome|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|cellular biosynthetic process|protein metabolic process|organelle organization|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|ribosome|mitochondrial inner membrane|mitochondrial matrix|mitochondrion|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|mitochondrial small ribosomal subunit|macromolecule biosynthetic process|small ribosomal subunit|mitochondrial translation|protein complex disassembly|peptide biosynthetic process|mitochondrial translational elongation|translation|poly(A) RNA binding|mitochondrial translational termination|translational elongation|cellular protein complex disassembly|translational termination - - - - 8:79918717-80030289 56 64 93 378 465 337 0.989330246739245 1.02756926400111 1.48131667452797 5.98329888826846 6.74020393529901 5.57969951606071 1.16607206175611 6.10106744654273 -2.38740473158374 2.53632546457839e-18 1.69394766039202e-16 DOWN ENSG00000173163 COMMD1 copper metabolism (Murr1) domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23024] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0051051|GO:0044237|GO:0051641|GO:0043227|GO:0008289|GO:1903828|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0042802|GO:0060341|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0043168|GO:0005543|GO:0031982|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0032880|GO:0042592|GO:0046983|GO:0045184|GO:0009890|GO:2000009|GO:0006139|GO:0008104|GO:0044092|GO:0055085|GO:0070062|GO:0051649|GO:0010008|GO:0000151|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0034763|GO:0043271|GO:0005768|GO:0051090|GO:0016192|GO:0032268|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0030163|GO:0031410|GO:0010629|GO:0005769|GO:0031461|GO:0048878|GO:0035091|GO:0051252|GO:0015031|GO:0044265|GO:0016023|GO:0036211|GO:0046907|GO:0006811|GO:0055037|GO:0010766|GO:0031981|GO:1990234|GO:0034766|GO:0051247|GO:0006508|GO:0031988|GO:0034765|GO:0005654|GO:0043433|GO:0043269|GO:0034613|GO:0032270|GO:0044267|GO:0042176|GO:0010467|GO:0070300|GO:0051246|GO:0009059|GO:1903827|GO:0016070|GO:0005634|GO:0042803|GO:0034220|GO:0044257|GO:2000008|GO:0098655|GO:0031462|GO:0031401|GO:0048227|GO:0010498|GO:0045892|GO:0032774|GO:0030162|GO:0006812|GO:2001141|GO:1902679|GO:0048193|GO:0034394|GO:0051603|GO:0016197|GO:1901981|GO:0032088|GO:0046914|GO:0050801|GO:0006464|GO:1902306|GO:0006351|GO:0006355|GO:1903507|GO:0005507|GO:0019941|GO:1902936|GO:1903506|GO:0002028|GO:1902305|GO:0030001|GO:0005547|GO:0006892|GO:0061136|GO:0015672|GO:0043161|GO:0032446|GO:0006511|GO:0031398|GO:0035725|GO:0006814|GO:0055065|GO:0031396|GO:0032434|GO:0080025|GO:0006893|GO:0005546|GO:0043325|GO:0016567|GO:0055070 macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|negative regulation of transport|cellular metabolic process|cellular localization|membrane-bounded organelle|lipid binding|negative regulation of cellular protein localization|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|identical protein binding|regulation of cellular localization|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|phospholipid binding|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|regulation of protein localization|homeostatic process|protein dimerization activity|establishment of protein localization|negative regulation of biosynthetic process|negative regulation of protein localization to cell surface|nucleobase-containing compound metabolic process|protein localization|negative regulation of molecular function|transmembrane transport|extracellular exosome|establishment of localization in cell|endosome membrane|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of transmembrane transport|negative regulation of ion transport|endosome|regulation of sequence-specific DNA binding transcription factor activity|vesicle-mediated transport|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|protein catabolic process|cytoplasmic vesicle|negative regulation of gene expression|early endosome|cullin-RING ubiquitin ligase complex|chemical homeostasis|phosphatidylinositol binding|regulation of RNA metabolic process|protein transport|cellular macromolecule catabolic process|cytoplasmic, membrane-bounded vesicle|protein modification process|intracellular transport|ion transport|recycling endosome|negative regulation of sodium ion transport|nuclear lumen|transferase complex|negative regulation of ion transmembrane transport|positive regulation of protein metabolic process|proteolysis|membrane-bounded vesicle|regulation of ion transmembrane transport|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of ion transport|cellular protein localization|positive regulation of cellular protein metabolic process|cellular protein metabolic process|regulation of protein catabolic process|gene expression|phosphatidic acid binding|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of cellular protein localization|RNA metabolic process|nucleus|protein homodimerization activity|ion transmembrane transport|cellular protein catabolic process|regulation of protein localization to cell surface|cation transmembrane transport|Cul2-RING ubiquitin ligase complex|positive regulation of protein modification process|plasma membrane to endosome transport|proteasomal protein catabolic process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of proteolysis|cation transport|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|Golgi vesicle transport|protein localization to cell surface|proteolysis involved in cellular protein catabolic process|endosomal transport|phosphatidylinositol phosphate binding|negative regulation of NF-kappaB transcription factor activity|transition metal ion binding|ion homeostasis|cellular protein modification process|negative regulation of sodium ion transmembrane transport|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|copper ion binding|modification-dependent protein catabolic process|phosphatidylinositol bisphosphate binding|regulation of nucleic acid-templated transcription|regulation of sodium ion transport|regulation of sodium ion transmembrane transport|metal ion transport|phosphatidylinositol-3,4,5-trisphosphate binding|post-Golgi vesicle-mediated transport|regulation of proteasomal protein catabolic process|monovalent inorganic cation transport|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|sodium ion transmembrane transport|sodium ion transport|metal ion homeostasis|regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process|phosphatidylinositol-3,5-bisphosphate binding|Golgi to plasma membrane transport|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|protein ubiquitination|copper ion homeostasis - - - - 2:61888724-62147247 5 10 12 125 105 86 0.078252421507804 0.14222854442272 0.169322261938177 1.75272523095136 1.348235273375 1.26134497123623 0.129934409289567 1.45410182518753 -3.48427285755447 2.58138862776531e-18 1.72019589493986e-16 DOWN ENSG00000005020 SKAP2 src kinase associated phosphoprotein 2 [Source:HGNC Symbol;Acc:HGNC:15687] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006955|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0035591|GO:0002757|GO:0042127|GO:0022607|GO:0043231|GO:0005737|GO:0001775|GO:0009966|GO:0030674|GO:0010646|GO:0050776|GO:0046649|GO:0007154|GO:0007165|GO:0050778|GO:0008285|GO:0009967|GO:0005829|GO:0042113|GO:0031981|GO:0005654|GO:0002764|GO:0006461|GO:0005070|GO:0005634 immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|binding, bridging|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|immune response|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|signaling adaptor activity|immune response-activating signal transduction|regulation of cell proliferation|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cell activation|regulation of signal transduction|protein binding, bridging|regulation of cell communication|regulation of immune response|lymphocyte activation|cell communication|signal transduction|positive regulation of immune response|negative regulation of cell proliferation|positive regulation of signal transduction|cytosol|B cell activation|nuclear lumen|nucleoplasm|immune response-regulating signaling pathway|protein complex assembly|SH3/SH2 adaptor activity|nucleus - - - - 7:26667062-26995239 166 174 456 1710 1836 2292 1.8307298935121 1.74399603395044 4.53415302129876 16.8970382319303 16.613354184053 23.6897471850778 2.7029596495871 19.0667132003537 -2.81844428703048 2.5917890229974e-18 1.72128990289301e-16 DOWN ENSG00000148339 SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 [Source:HGNC Symbol;Acc:HGNC:20663] GO:0032502|GO:0040007|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0014823|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0003735|GO:0043227|GO:0009605|GO:0009058|GO:0031224|GO:0048589|GO:0005622|GO:0048856|GO:0031090|GO:0006725|GO:0019866|GO:0009888|GO:0006810|GO:1901360|GO:0009991|GO:0007275|GO:0048513|GO:0034641|GO:0015980|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0007423|GO:0035264|GO:0031966|GO:0006139|GO:0055086|GO:0055085|GO:0002021|GO:0070062|GO:0006091|GO:0016021|GO:0032094|GO:0044249|GO:0019538|GO:0055114|GO:0005740|GO:0034645|GO:0006518|GO:0046872|GO:0001654|GO:0019693|GO:0009116|GO:0006811|GO:0005743|GO:0005739|GO:0006796|GO:0043603|GO:0044267|GO:0010467|GO:0045333|GO:0009059|GO:0061448|GO:0031667|GO:0060612|GO:0034220|GO:0098655|GO:0043043|GO:0009259|GO:0043010|GO:0009117|GO:0006812|GO:0005509|GO:0006412|GO:0006163|GO:0042278|GO:0030001|GO:0046034|GO:0070588|GO:0006816 developmental process|growth|structural molecule activity|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|response to activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|response to external stimulus|biosynthetic process|intrinsic component of membrane|developmental growth|intracellular|anatomical structure development|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|tissue development|transport|organic cyclic compound metabolic process|response to extracellular stimulus|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|sensory organ development|multicellular organism growth|mitochondrial membrane|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|transmembrane transport|response to dietary excess|extracellular exosome|generation of precursor metabolites and energy|integral component of membrane|response to food|cellular biosynthetic process|protein metabolic process|oxidation-reduction process|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|eye development|ribose phosphate metabolic process|nucleoside metabolic process|ion transport|mitochondrial inner membrane|mitochondrion|phosphate-containing compound metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|cellular respiration|macromolecule biosynthetic process|connective tissue development|response to nutrient levels|adipose tissue development|ion transmembrane transport|cation transmembrane transport|peptide biosynthetic process|ribonucleotide metabolic process|camera-type eye development|nucleotide metabolic process|cation transport|calcium ion binding|translation|purine nucleotide metabolic process|purine nucleoside metabolic process|metal ion transport|ATP metabolic process|calcium ion transmembrane transport|calcium ion transport - - - - 9:128068201-128109245 1041 1035 1073 333 384 338 8.77885687504865 7.93245695348242 8.15833106355502 2.51610473994247 2.65696605251173 2.67136416400629 8.28988163069536 2.6148116521535 1.66464447070288 2.59456172138359e-18 1.72128990289301e-16 UP ENSG00000132485 ZRANB2 zinc finger, RAN-binding domain containing 2 [Source:HGNC Symbol;Acc:HGNC:13058] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0003723|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006396|GO:0032774|GO:2001141|GO:0016071|GO:0046914|GO:0044822|GO:0006351|GO:0006355|GO:1903506|GO:0006397|GO:0008380|GO:0008270 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA processing|RNA biosynthetic process|regulation of RNA biosynthetic process|mRNA metabolic process|transition metal ion binding|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|mRNA processing|RNA splicing|zinc ion binding - - - - 1:71063291-71081297 507 559 903 2615 3193 2474 2.87414698420553 2.87999938186069 4.61532930878932 13.2822022137617 14.851406682109 13.1440555341875 3.45649189161851 13.7592214766861 -1.99301839545066 2.75875160946259e-18 1.82615899221499e-16 DOWN ENSG00000172461 FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) [Source:HGNC Symbol;Acc:HGNC:4020] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0006486|GO:0007275|GO:0044281|GO:0043231|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0043412|GO:0009100|GO:0036211|GO:0016758|GO:0005996|GO:0070085|GO:0016052|GO:0005795|GO:1901137|GO:0044267|GO:0007399|GO:0000139|GO:0009059|GO:0019318|GO:0009101|GO:0008417|GO:0043413|GO:0036065|GO:0031985|GO:0032580|GO:0006464|GO:0006004|GO:0046920|GO:0042355 developmental process|cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|anatomical structure development|organelle membrane|protein glycosylation|multicellular organism development|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|macromolecule modification|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|monosaccharide metabolic process|glycosylation|carbohydrate catabolic process|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|nervous system development|Golgi membrane|macromolecule biosynthetic process|hexose metabolic process|glycoprotein biosynthetic process|fucosyltransferase activity|macromolecule glycosylation|fucosylation|Golgi cisterna|Golgi cisterna membrane|cellular protein modification process|fucose metabolic process|alpha-(1->3)-fucosyltransferase activity|L-fucose catabolic process K03663 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase[2.4.1.152] hsa01100|hsa00514|hsa00601|hsa00603 Metabolic pathways - Homo sapiens (human)|Other types of O-glycan biosynthesis - Homo sapiens (human)|Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human)|Glycosphingolipid biosynthesis - globo series - Homo sapiens (human) 6:96015984-96215612 82 117 230 791 926 1047 0.422801749802837 0.548264798302281 1.06921433552895 3.65424267653525 3.91743992454887 5.05940079360891 0.680093627878023 4.21036113156434 -2.63013870192168 2.85896487269158e-18 1.88830834755164e-16 DOWN ENSG00000115464 USP34 ubiquitin specific peptidase 34 [Source:HGNC Symbol;Acc:HGNC:20066] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0016570|GO:0034641|GO:0046483|GO:0043231|GO:0008233|GO:0005737|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009967|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0030111|GO:0005829|GO:0010468|GO:0036459|GO:0034645|GO:0007166|GO:0016578|GO:0043412|GO:0030163|GO:0051252|GO:0006325|GO:0044265|GO:0036211|GO:0031981|GO:1990234|GO:0006508|GO:0005654|GO:0044267|GO:0010467|GO:0000123|GO:0030177|GO:0009059|GO:0016070|GO:0005634|GO:0016055|GO:0044257|GO:0060828|GO:0032774|GO:2001141|GO:0051603|GO:0004175|GO:0070646|GO:0016568|GO:0070461|GO:0004843|GO:0008234|GO:0006464|GO:0090263|GO:0006351|GO:0006355|GO:0019941|GO:1903506|GO:0060070|GO:0016579|GO:0000124|GO:0004197|GO:0006511|GO:0071108 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of Wnt signaling pathway|cytosol|regulation of gene expression|thiol-dependent ubiquitinyl hydrolase activity|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|histone deubiquitination|macromolecule modification|protein catabolic process|regulation of RNA metabolic process|chromatin organization|cellular macromolecule catabolic process|protein modification process|nuclear lumen|transferase complex|proteolysis|nucleoplasm|cellular protein metabolic process|gene expression|histone acetyltransferase complex|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|RNA metabolic process|nucleus|Wnt signaling pathway|cellular protein catabolic process|regulation of canonical Wnt signaling pathway|RNA biosynthetic process|regulation of RNA biosynthetic process|proteolysis involved in cellular protein catabolic process|endopeptidase activity|protein modification by small protein removal|chromatin modification|SAGA-type complex|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|positive regulation of canonical Wnt signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|protein deubiquitination|SAGA complex|cysteine-type endopeptidase activity|ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination - - - - 2:61187463-61470769 605 719 994 2798 2996 3004 1.73768988722516 1.87683127413955 2.57405047002963 7.2004897921148 7.060351512908 8.08621944782596 2.06285721046478 7.44902025094959 -1.85240672202291 2.91079566167057e-18 1.91829787380824e-16 DOWN ENSG00000162946 DISC1 disrupted in schizophrenia 1 [Source:HGNC Symbol;Acc:HGNC:2888] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0008021|GO:0044877|GO:0008283|GO:0050794|GO:0060076|GO:0043229|GO:0016049|GO:0071704|GO:0009056|GO:0009628|GO:0032947|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009893|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0097060|GO:0005929|GO:0048646|GO:0019222|GO:0008284|GO:0042127|GO:0045595|GO:0051602|GO:0048468|GO:0051130|GO:0007275|GO:0048513|GO:0032535|GO:0016358|GO:0030307|GO:0005874|GO:0030155|GO:0030900|GO:0031982|GO:0031325|GO:0051128|GO:0045211|GO:0007420|GO:0022607|GO:0050803|GO:0045597|GO:0043231|GO:0030133|GO:0005737|GO:0097546|GO:0060322|GO:0021987|GO:0006928|GO:0032403|GO:0042592|GO:0043005|GO:0031589|GO:0009966|GO:0019725|GO:0048639|GO:0014069|GO:0036064|GO:0010646|GO:0005875|GO:0008104|GO:0007154|GO:0060996|GO:0016477|GO:0007165|GO:0048588|GO:0005783|GO:0048638|GO:0050808|GO:0045785|GO:0008092|GO:0061351|GO:0021543|GO:0030030|GO:0048869|GO:0021537|GO:0009967|GO:0007017|GO:0019538|GO:0001558|GO:0031323|GO:0006996|GO:0072089|GO:0060560|GO:0032268|GO:0030111|GO:0000902|GO:0060998|GO:0045732|GO:0031175|GO:0022029|GO:0005813|GO:0031344|GO:0005871|GO:0007166|GO:0030424|GO:0043412|GO:0007010|GO:0050807|GO:0050773|GO:0030163|GO:0007417|GO:0031410|GO:0010720|GO:0048878|GO:0005815|GO:0007405|GO:0044265|GO:0031346|GO:0000904|GO:0016023|GO:0021885|GO:0036211|GO:0044782|GO:0070382|GO:0007160|GO:0001764|GO:0055082|GO:0050769|GO:0030031|GO:0008361|GO:0010810|GO:0051247|GO:0030286|GO:0048471|GO:0006508|GO:0031988|GO:0021846|GO:0022604|GO:0005739|GO:0034613|GO:0021872|GO:0070925|GO:0032270|GO:0021795|GO:0042384|GO:0035556|GO:0044267|GO:0042176|GO:0030516|GO:0019894|GO:0032990|GO:2000179|GO:0007399|GO:0051246|GO:0030177|GO:0010770|GO:0010811|GO:0030154|GO:0048858|GO:2000177|GO:0000226|GO:0060074|GO:0005856|GO:0005634|GO:1990138|GO:0051960|GO:2000648|GO:0045773|GO:0072091|GO:0048666|GO:0008347|GO:0030182|GO:0060271|GO:0016055|GO:0021953|GO:0044257|GO:0035058|GO:0010975|GO:0033365|GO:0031401|GO:0031929|GO:0021799|GO:0010769|GO:1902692|GO:1903364|GO:0021852|GO:0030162|GO:0045862|GO:0061564|GO:0051603|GO:0001952|GO:0015630|GO:0021954|GO:0001954|GO:0090128|GO:0050801|GO:0021879|GO:0050772|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0010976|GO:0006873|GO:0048675|GO:0002052|GO:0045666|GO:0021859|GO:1903052|GO:0007409|GO:0019941|GO:0048699|GO:0060070|GO:0021801|GO:0044380|GO:0042063|GO:0021884|GO:0050770|GO:0045664|GO:0030003|GO:0032446|GO:0006511|GO:0031398|GO:0021860|GO:2000058|GO:0055065|GO:0031396|GO:0006875|GO:2000060|GO:0071539|GO:0006874|GO:0042787|GO:0055074|GO:0016567|GO:0051560 locomotion|developmental process|growth|macromolecular complex|synapse|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|synaptic vesicle|macromolecular complex binding|cell proliferation|regulation of cellular process|excitatory synapse|intracellular organelle|cell growth|organic substance metabolic process|catabolic process|response to abiotic stimulus|protein complex scaffold|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|positive regulation of metabolic process|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|synaptic membrane|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|regulation of cell differentiation|response to electrical stimulus|cell development|positive regulation of cellular component organization|multicellular organism development|animal organ development|regulation of cellular component size|dendrite development|positive regulation of cell growth|microtubule|regulation of cell adhesion|forebrain development|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|postsynaptic membrane|brain development|cellular component assembly|regulation of synapse structure or activity|positive regulation of cell differentiation|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|ciliary base|head development|cerebral cortex development|movement of cell or subcellular component|protein complex binding|homeostatic process|neuron projection|cell-substrate adhesion|regulation of signal transduction|cellular homeostasis|positive regulation of developmental growth|postsynaptic density|ciliary basal body|regulation of cell communication|microtubule associated complex|protein localization|cell communication|dendritic spine development|cell migration|signal transduction|developmental cell growth|endoplasmic reticulum|regulation of developmental growth|synapse organization|positive regulation of cell adhesion|cytoskeletal protein binding|neural precursor cell proliferation|pallium development|cell projection organization|cellular developmental process|telencephalon development|positive regulation of signal transduction|microtubule-based process|protein metabolic process|regulation of cell growth|regulation of cellular metabolic process|organelle organization|stem cell proliferation|developmental growth involved in morphogenesis|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|regulation of dendritic spine development|positive regulation of protein catabolic process|neuron projection development|telencephalon cell migration|centrosome|regulation of cell projection organization|kinesin complex|cell surface receptor signaling pathway|axon|macromolecule modification|cytoskeleton organization|regulation of synapse organization|regulation of dendrite development|protein catabolic process|central nervous system development|cytoplasmic vesicle|positive regulation of cell development|chemical homeostasis|microtubule organizing center|neuroblast proliferation|cellular macromolecule catabolic process|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|cytoplasmic, membrane-bounded vesicle|forebrain cell migration|protein modification process|cilium organization|exocytic vesicle|cell-matrix adhesion|neuron migration|cellular chemical homeostasis|positive regulation of neurogenesis|cell projection assembly|regulation of cell size|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|dynein complex|perinuclear region of cytoplasm|proteolysis|membrane-bounded vesicle|cell proliferation in forebrain|regulation of cell morphogenesis|mitochondrion|cellular protein localization|forebrain generation of neurons|organelle assembly|positive regulation of cellular protein metabolic process|cerebral cortex cell migration|cilium assembly|intracellular signal transduction|cellular protein metabolic process|regulation of protein catabolic process|regulation of axon extension|kinesin binding|cell part morphogenesis|positive regulation of neural precursor cell proliferation|nervous system development|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|positive regulation of cell morphogenesis involved in differentiation|positive regulation of cell-substrate adhesion|cell differentiation|cell projection morphogenesis|regulation of neural precursor cell proliferation|microtubule cytoskeleton organization|synapse maturation|cytoskeleton|nucleus|neuron projection extension|regulation of nervous system development|positive regulation of stem cell proliferation|positive regulation of axon extension|regulation of stem cell proliferation|neuron development|glial cell migration|neuron differentiation|cilium morphogenesis|Wnt signaling pathway|central nervous system neuron differentiation|cellular protein catabolic process|nonmotile primary cilium assembly|regulation of neuron projection development|protein localization to organelle|positive regulation of protein modification process|TOR signaling|cerebral cortex radially oriented cell migration|regulation of cell morphogenesis involved in differentiation|regulation of neuroblast proliferation|positive regulation of cellular protein catabolic process|pyramidal neuron migration|regulation of proteolysis|positive regulation of proteolysis|axon development|proteolysis involved in cellular protein catabolic process|regulation of cell-matrix adhesion|microtubule cytoskeleton|central nervous system neuron development|positive regulation of cell-matrix adhesion|regulation of synapse maturation|ion homeostasis|forebrain neuron differentiation|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|cellular ion homeostasis|axon extension|positive regulation of neuroblast proliferation|positive regulation of neuron differentiation|pyramidal neuron differentiation|positive regulation of proteolysis involved in cellular protein catabolic process|axonogenesis|modification-dependent protein catabolic process|generation of neurons|canonical Wnt signaling pathway|cerebral cortex radial glia guided migration|protein localization to cytoskeleton|gliogenesis|forebrain neuron development|regulation of axonogenesis|regulation of neuron differentiation|cellular cation homeostasis|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|pyramidal neuron development|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|metal ion homeostasis|regulation of protein ubiquitination|cellular metal ion homeostasis|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein localization to centrosome|cellular calcium ion homeostasis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|calcium ion homeostasis|protein ubiquitination|mitochondrial calcium ion homeostasis - - - - 1:231626815-232041272 4 7 6 71 75 76 0.00952768897469896 0.0151549548495203 0.012886190462698 0.151531527463468 0.146581431359798 0.169664308306176 0.0125229447623058 0.155925755709814 -3.63821349502474 2.97801131769476e-18 1.95827202375461e-16 DOWN ENSG00000089006 SNX5 sorting nexin 5 [Source:HGNC Symbol;Acc:HGNC:14969] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0019898|GO:0042995|GO:0043229|GO:0030905|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0030904|GO:0031252|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0009898|GO:0006810|GO:0043168|GO:0005543|GO:0031982|GO:0043231|GO:0005737|GO:0012506|GO:0001726|GO:0031234|GO:0098562|GO:0046983|GO:0045184|GO:0019897|GO:0001891|GO:0008104|GO:0051649|GO:0008092|GO:0070685|GO:0010008|GO:0005768|GO:0006996|GO:0016192|GO:0016050|GO:0031410|GO:0005769|GO:0046982|GO:0035091|GO:0015031|GO:0016023|GO:0046907|GO:0097422|GO:0031988|GO:0031901|GO:0031313|GO:0034613|GO:0030659|GO:0034452|GO:0042147|GO:0016482|GO:0006886|GO:0016197|GO:0006897|GO:0006907 macromolecular complex|cell|membrane|cellular process|binding|extrinsic component of membrane|cell projection|intracellular organelle|retromer, tubulation complex|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|retromer complex|cell leading edge|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|cytoplasmic side of plasma membrane|transport|anion binding|phospholipid binding|vesicle|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|ruffle|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|protein dimerization activity|establishment of protein localization|extrinsic component of plasma membrane|phagocytic cup|protein localization|establishment of localization in cell|cytoskeletal protein binding|macropinocytic cup|endosome membrane|endosome|organelle organization|vesicle-mediated transport|vesicle organization|cytoplasmic vesicle|early endosome|protein heterodimerization activity|phosphatidylinositol binding|protein transport|cytoplasmic, membrane-bounded vesicle|intracellular transport|tubular endosome|membrane-bounded vesicle|early endosome membrane|extrinsic component of endosome membrane|cellular protein localization|cytoplasmic vesicle membrane|dynactin binding|retrograde transport, endosome to Golgi|cytosolic transport|intracellular protein transport|endosomal transport|endocytosis|pinocytosis K17920 sorting nexin-5/6/32[-] hsa04144 Endocytosis - Homo sapiens (human) 20:17941597-17968980 1008 1157 1336 4444 4819 3685 4.5966183921606 4.79502964024349 5.49286196312119 18.1572343662578 18.0302938090453 15.7486878870111 4.96150333184176 17.3120720207714 -1.80292917861895 2.99247697695597e-18 1.96345950923173e-16 DOWN ENSG00000032389 TSSC1 tumor suppressing subtransferable candidate 1 [Source:HGNC Symbol;Acc:HGNC:12383] GO:0005488|GO:0005515 binding|protein binding - - - - 2:3188925-3377882 76 77 103 461 573 362 0.668825059449631 0.615843827413065 0.81723967215441 3.63493147791293 4.13733185278022 2.98562727631267 0.700636186339035 3.58596353566861 -2.35562341080492 3.10458424667898e-18 2.03254951974461e-16 DOWN ENSG00000120725 SIL1 SIL1 nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:24624] GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:0043229|GO:0051641|GO:0006457|GO:0043227|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0005783|GO:0051649|GO:0051082|GO:0015031|GO:0046907|GO:0034613|GO:0005788|GO:0006886 cell|cellular process|extracellular region|binding|intracellular organelle|cellular localization|protein folding|membrane-bounded organelle|extracellular space|intracellular|protein binding|endomembrane system|transport|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|endoplasmic reticulum|establishment of localization in cell|unfolded protein binding|protein transport|intracellular transport|cellular protein localization|endoplasmic reticulum lumen|intracellular protein transport K14001 nucleotide exchange factor SIL1[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 5:138946720-139293557 37 55 71 305 330 304 0.390866371043228 0.528051379779972 0.676245754067511 2.88687078910665 2.86030643239065 3.00976780135017 0.531721168296904 2.91898167428249 -2.45672334579487 3.16396384158957e-18 2.066892265357e-16 DOWN ENSG00000203875 SNHG5 small nucleolar RNA host gene 5 [Source:HGNC Symbol;Acc:HGNC:21026] - - - - - - 6:85660950-85678736 781 773 622 201 167 183 5.17812950689375 4.65781008352182 3.71815044677568 1.194032674627 0.908461361839316 1.13711151678988 4.51803001239708 1.07986851775207 2.06483819037541 3.42102538208394e-18 2.22994086805096e-16 UP ENSG00000119986 AVPI1 arginine vasopressin induced 1 [Source:HGNC Symbol;Acc:HGNC:30898] GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0023051|GO:0009893|GO:0005515|GO:0019222|GO:0007049|GO:0031325|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0043412|GO:0051347|GO:0036211|GO:0051247|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:1902531|GO:0031401|GO:0043408|GO:0016310|GO:0043410|GO:0006464|GO:0043549|GO:0033674|GO:0045859|GO:0045860|GO:0043406|GO:0006468|GO:0043405|GO:0042325|GO:0001932|GO:0001934|GO:0042327|GO:0000187|GO:0071902|GO:0071900|GO:0032147 signaling|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|regulation of signaling|positive regulation of metabolic process|protein binding|regulation of metabolic process|cell cycle|positive regulation of cellular metabolic process|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|macromolecule modification|positive regulation of transferase activity|protein modification process|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of intracellular signal transduction|positive regulation of protein modification process|regulation of MAPK cascade|phosphorylation|positive regulation of MAPK cascade|cellular protein modification process|regulation of kinase activity|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity - - - - 10:97677424-97687323 1374 1300 1450 436 477 455 66.7072211635579 57.3600647916416 63.46998795779 18.9657446557304 19.0008143856252 20.7026918677992 62.5124246376632 19.5564169697183 1.67650088965178 3.473802126936e-18 2.25940933981584e-16 UP ENSG00000197329 PELI1 pellino E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:8827] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0051707|GO:0007155|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0016874|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0019222|GO:0008284|GO:0002757|GO:0042127|GO:0016337|GO:0045087|GO:0006725|GO:0070661|GO:0050867|GO:1901360|GO:0034123|GO:0070489|GO:0034641|GO:0006952|GO:0030155|GO:0031325|GO:0046483|GO:0001817|GO:0098609|GO:0043231|GO:0005737|GO:0002218|GO:0001816|GO:0002696|GO:0001775|GO:0009966|GO:0009890|GO:0001819|GO:0010646|GO:0006139|GO:0009617|GO:0007162|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0002695|GO:0008285|GO:0019787|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0051090|GO:1902533|GO:0051249|GO:0032268|GO:0005829|GO:0042113|GO:0010468|GO:0034645|GO:0032943|GO:0007166|GO:0033993|GO:0043412|GO:0002758|GO:0010629|GO:0004842|GO:0002237|GO:0051252|GO:0034109|GO:0034145|GO:0036211|GO:0043331|GO:0051251|GO:0051250|GO:0022408|GO:0022407|GO:0007159|GO:0051247|GO:0070664|GO:0043433|GO:0002764|GO:0032270|GO:0042110|GO:0014070|GO:0035556|GO:0044267|GO:0010467|GO:0051246|GO:0046651|GO:0009059|GO:0034121|GO:1902531|GO:0016070|GO:0032496|GO:0005634|GO:0045089|GO:0045088|GO:0034141|GO:1903038|GO:0042098|GO:0031401|GO:0050863|GO:0043122|GO:0061630|GO:0045892|GO:0032774|GO:0050868|GO:2001141|GO:1902679|GO:0050871|GO:0002221|GO:0070486|GO:0008063|GO:0043123|GO:0007249|GO:0050864|GO:0032088|GO:0042100|GO:0034111|GO:0032945|GO:0006464|GO:0050671|GO:0050672|GO:0006351|GO:0006355|GO:0032946|GO:0030890|GO:1903507|GO:0002224|GO:1903506|GO:0030888|GO:0042130|GO:0042129|GO:0071593|GO:0032446|GO:0031398|GO:0034166|GO:0034134|GO:0038124|GO:0031396|GO:0034138|GO:0002755|GO:0034146|GO:0034142|GO:0038123|GO:0034162|GO:0016567|GO:0000209|GO:0070936 immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|response to other organism|cell adhesion|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|ligase activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|transferase activity|regulation of metabolic process|positive regulation of cell proliferation|immune response-activating signal transduction|regulation of cell proliferation|single organismal cell-cell adhesion|innate immune response|cellular aromatic compound metabolic process|leukocyte proliferation|positive regulation of cell activation|organic cyclic compound metabolic process|positive regulation of toll-like receptor signaling pathway|T cell aggregation|cellular nitrogen compound metabolic process|defense response|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cytokine production|cell-cell adhesion|intracellular membrane-bounded organelle|cytoplasm|activation of innate immune response|cytokine production|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|negative regulation of biosynthetic process|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|negative regulation of cell adhesion|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|negative regulation of leukocyte activation|negative regulation of cell proliferation|ubiquitin-like protein transferase activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|mononuclear cell proliferation|cell surface receptor signaling pathway|response to lipid|macromolecule modification|innate immune response-activating signal transduction|negative regulation of gene expression|ubiquitin-protein transferase activity|response to molecule of bacterial origin|regulation of RNA metabolic process|homotypic cell-cell adhesion|positive regulation of toll-like receptor 4 signaling pathway|protein modification process|response to dsRNA|positive regulation of lymphocyte activation|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|negative regulation of leukocyte proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|T cell activation|response to organic cyclic compound|intracellular signal transduction|cellular protein metabolic process|gene expression|regulation of protein metabolic process|lymphocyte proliferation|macromolecule biosynthetic process|regulation of toll-like receptor signaling pathway|regulation of intracellular signal transduction|RNA metabolic process|response to lipopolysaccharide|nucleus|positive regulation of innate immune response|regulation of innate immune response|positive regulation of toll-like receptor 3 signaling pathway|negative regulation of leukocyte cell-cell adhesion|T cell proliferation|positive regulation of protein modification process|regulation of T cell activation|regulation of I-kappaB kinase/NF-kappaB signaling|ubiquitin protein ligase activity|negative regulation of transcription, DNA-templated|RNA biosynthetic process|negative regulation of T cell activation|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|positive regulation of B cell activation|pattern recognition receptor signaling pathway|leukocyte aggregation|Toll signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|regulation of B cell activation|negative regulation of NF-kappaB transcription factor activity|B cell proliferation|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|cellular protein modification process|positive regulation of lymphocyte proliferation|negative regulation of lymphocyte proliferation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of mononuclear cell proliferation|positive regulation of B cell proliferation|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|regulation of nucleic acid-templated transcription|regulation of B cell proliferation|negative regulation of T cell proliferation|regulation of T cell proliferation|lymphocyte aggregation|protein modification by small protein conjugation|positive regulation of protein ubiquitination|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|regulation of protein ubiquitination|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|protein ubiquitination|protein polyubiquitination|protein K48-linked ubiquitination - - - - 2:64092652-64144454 602 642 733 167 157 215 8.3644849191244 8.10695517267302 9.1824940618831 2.07901192991066 1.78982016873225 2.79968536141611 8.55131138456017 2.22283915335301 1.94374212373274 3.76241386202502e-18 2.44180659645424e-16 UP ENSG00000018699 TTC27 tetratricopeptide repeat domain 27 [Source:HGNC Symbol;Acc:HGNC:25986] GO:0005488|GO:0005515 binding|protein binding - - - - 2:32628032-32821051 57 55 118 523 538 416 1.07462119947166 0.94238593790157 2.00575956571188 8.83450528908949 8.32210348812076 7.3502999461355 1.3409222343617 8.16896957444858 -2.60692853795235 3.90809867637229e-18 2.53085418404378e-16 DOWN ENSG00000055917 PUM2 pumilio RNA binding family member 2 [Source:HGNC Symbol;Acc:HGNC:14958] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0002757|GO:0045087|GO:0050688|GO:0003676|GO:0034641|GO:0006952|GO:0039528|GO:0022607|GO:0098542|GO:0001817|GO:0043231|GO:1900246|GO:0005737|GO:0002218|GO:0001816|GO:0030529|GO:0005635|GO:0009615|GO:0009966|GO:0009890|GO:0001819|GO:0016458|GO:0010646|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0060968|GO:0031965|GO:0051607|GO:0009967|GO:0044249|GO:0022613|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0035770|GO:1902533|GO:0032268|GO:2000637|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0002758|GO:0031047|GO:0010629|GO:0039529|GO:0032269|GO:0022618|GO:0098586|GO:0048471|GO:0002764|GO:0070925|GO:0043603|GO:0035556|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:1902531|GO:0005634|GO:0036464|GO:0045089|GO:0016441|GO:0030522|GO:0045088|GO:0043043|GO:0034622|GO:0017148|GO:0034063|GO:0010608|GO:0002221|GO:0006412|GO:0040029|GO:0006417|GO:0060964|GO:0044822|GO:0010494|GO:0035194|GO:0039535|GO:0003729|GO:0035195|GO:0003730 macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|immune response-activating signal transduction|innate immune response|regulation of defense response to virus|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|cytoplasmic pattern recognition receptor signaling pathway in response to virus|cellular component assembly|defense response to other organism|regulation of cytokine production|intracellular membrane-bounded organelle|positive regulation of RIG-I signaling pathway|cytoplasm|activation of innate immune response|cytokine production|intracellular ribonucleoprotein complex|nuclear envelope|response to virus|regulation of signal transduction|negative regulation of biosynthetic process|positive regulation of cytokine production|gene silencing|regulation of cell communication|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|regulation of gene silencing|nuclear membrane|defense response to virus|positive regulation of signal transduction|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|ribonucleoprotein granule|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|positive regulation of gene silencing by miRNA|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|innate immune response-activating signal transduction|gene silencing by RNA|negative regulation of gene expression|RIG-I signaling pathway|negative regulation of cellular protein metabolic process|ribonucleoprotein complex assembly|cellular response to virus|perinuclear region of cytoplasm|immune response-regulating signaling pathway|organelle assembly|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|nucleus|cytoplasmic ribonucleoprotein granule|positive regulation of innate immune response|posttranscriptional gene silencing|intracellular receptor signaling pathway|regulation of innate immune response|peptide biosynthetic process|cellular macromolecular complex assembly|negative regulation of translation|stress granule assembly|posttranscriptional regulation of gene expression|pattern recognition receptor signaling pathway|translation|regulation of gene expression, epigenetic|regulation of translation|regulation of gene silencing by miRNA|poly(A) RNA binding|cytoplasmic stress granule|posttranscriptional gene silencing by RNA|regulation of RIG-I signaling pathway|mRNA binding|gene silencing by miRNA|mRNA 3'-UTR binding - - - - 2:20248691-20352234 479 631 678 2710 2163 2182 2.567083399081 3.0733629848133 3.27603489141285 13.0128297541812 9.5110640235169 10.959443119614 2.97216042510238 11.161112299104 -1.90889691718996 4.15922597610082e-18 2.68765221408038e-16 DOWN ENSG00000110075 PPP6R3 protein phosphatase 6 regulatory subunit 3 [Source:HGNC Symbol;Acc:HGNC:1173] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0006486|GO:0051640|GO:0006810|GO:0022607|GO:0051668|GO:0043231|GO:0019899|GO:0005737|GO:0006903|GO:0005975|GO:0051656|GO:0061024|GO:0051649|GO:0050790|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0006996|GO:0016192|GO:0051650|GO:0032268|GO:0005829|GO:0034645|GO:0006900|GO:0016050|GO:0043412|GO:0006487|GO:0090114|GO:0030163|GO:0044265|GO:0009100|GO:0036211|GO:0046907|GO:0048199|GO:0019902|GO:0031981|GO:0005654|GO:0070085|GO:0006461|GO:0006796|GO:1901137|GO:0044267|GO:0051174|GO:0000139|GO:0051648|GO:0051246|GO:0009059|GO:0005634|GO:0009101|GO:0016311|GO:0043413|GO:0048208|GO:0018279|GO:0006516|GO:0048193|GO:0019903|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0043666|GO:0018193|GO:0043687|GO:0006888|GO:0035303 cell|membrane|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|biosynthetic process|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|protein glycosylation|organelle localization|transport|cellular component assembly|localization within membrane|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|vesicle targeting|carbohydrate metabolic process|establishment of organelle localization|membrane organization|establishment of localization in cell|regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|vesicle-mediated transport|establishment of vesicle localization|regulation of cellular protein metabolic process|cytosol|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|macromolecule modification|protein N-linked glycosylation|COPII-coated vesicle budding|protein catabolic process|cellular macromolecule catabolic process|glycoprotein metabolic process|protein modification process|intracellular transport|vesicle targeting, to, from or within Golgi|phosphatase binding|nuclear lumen|nucleoplasm|glycosylation|protein complex assembly|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|Golgi membrane|vesicle localization|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|glycoprotein biosynthetic process|dephosphorylation|macromolecule glycosylation|COPII vesicle coating|protein N-linked glycosylation via asparagine|glycoprotein catabolic process|Golgi vesicle transport|protein phosphatase binding|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|peptidyl-amino acid modification|post-translational protein modification|ER to Golgi vesicle-mediated transport|regulation of dephosphorylation - - - - 11:68460731-68615334 747 961 1233 3542 4128 3414 2.26598294557498 2.6493498251194 3.3721987343865 9.62680277818033 10.2740918335737 9.70573150520783 2.76251050169363 9.86887537232062 -1.83690573988852 4.55671670880027e-18 2.9381473137046e-16 DOWN ENSG00000147050 KDM6A lysine (K)-specific demethylase 6A [Source:HGNC Symbol;Acc:HGNC:12637] GO:0032502|GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0097159|GO:0032451|GO:0044877|GO:0016491|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0007507|GO:0007585|GO:0001756|GO:0035239|GO:0009888|GO:0051213|GO:0035295|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0032452|GO:0006482|GO:0043231|GO:0043169|GO:0007389|GO:0009887|GO:0035264|GO:0021915|GO:0048729|GO:0048598|GO:0070988|GO:0048568|GO:0003682|GO:0007154|GO:0001704|GO:0035148|GO:0007165|GO:0003016|GO:0048869|GO:0019538|GO:0006996|GO:0055114|GO:0051276|GO:0003677|GO:0010468|GO:0046872|GO:0007166|GO:0002009|GO:0043412|GO:0032525|GO:0072358|GO:0007498|GO:0009798|GO:0071558|GO:0009880|GO:0016571|GO:0006479|GO:0006325|GO:0003007|GO:0009790|GO:0010628|GO:0072175|GO:0036211|GO:0030903|GO:0007369|GO:0003002|GO:0001707|GO:0031981|GO:0016331|GO:1990234|GO:0005654|GO:0016577|GO:0001841|GO:0060429|GO:0044267|GO:0010467|GO:0048562|GO:0007399|GO:0060562|GO:0030154|GO:0060606|GO:0035097|GO:0072359|GO:0005634|GO:0048332|GO:0031490|GO:0016055|GO:0000975|GO:0000578|GO:0009792|GO:0043566|GO:0001843|GO:0048570|GO:0043565|GO:0048333|GO:0001838|GO:0003690|GO:0061053|GO:0070076|GO:0018022|GO:0009948|GO:0034968|GO:0009952|GO:0016568|GO:0006464|GO:0035282|GO:0051568|GO:0044212|GO:0060070|GO:0018193|GO:0071557|GO:0043009|GO:0000976|GO:0001012|GO:0001701|GO:0001159|GO:0018205|GO:0000977|GO:0000987|GO:0000978 developmental process|growth|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|methylation|organic cyclic compound binding|demethylase activity|macromolecular complex binding|oxidoreductase activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|heart development|respiratory gaseous exchange|somitogenesis|tube morphogenesis|tissue development|dioxygenase activity|tube development|multicellular organism development|histone modification|nucleic acid binding|animal organ development|histone demethylase activity|protein demethylation|intracellular membrane-bounded organelle|cation binding|pattern specification process|organ morphogenesis|multicellular organism growth|neural tube development|tissue morphogenesis|embryonic morphogenesis|demethylation|embryonic organ development|chromatin binding|cell communication|formation of primary germ layer|tube formation|signal transduction|respiratory system process|cellular developmental process|protein metabolic process|organelle organization|oxidation-reduction process|chromosome organization|DNA binding|regulation of gene expression|metal ion binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|macromolecule modification|somite rostral/caudal axis specification|cardiovascular system development|mesoderm development|axis specification|histone demethylase activity (H3-K27 specific)|embryonic pattern specification|histone methylation|protein methylation|chromatin organization|heart morphogenesis|embryo development|positive regulation of gene expression|epithelial tube formation|protein modification process|notochord development|gastrulation|regionalization|mesoderm formation|nuclear lumen|morphogenesis of embryonic epithelium|transferase complex|nucleoplasm|histone demethylation|neural tube formation|epithelium development|cellular protein metabolic process|gene expression|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|cell differentiation|tube closure|histone methyltransferase complex|circulatory system development|nucleus|mesoderm morphogenesis|chromatin DNA binding|Wnt signaling pathway|regulatory region DNA binding|embryonic axis specification|embryo development ending in birth or egg hatching|structure-specific DNA binding|neural tube closure|notochord morphogenesis|sequence-specific DNA binding|mesodermal cell differentiation|embryonic epithelial tube formation|double-stranded DNA binding|somite development|histone lysine demethylation|peptidyl-lysine methylation|anterior/posterior axis specification|histone lysine methylation|anterior/posterior pattern specification|chromatin modification|cellular protein modification process|segmentation|histone H3-K4 methylation|transcription regulatory region DNA binding|canonical Wnt signaling pathway|peptidyl-amino acid modification|histone H3-K27 demethylation|chordate embryonic development|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|core promoter proximal region DNA binding|peptidyl-lysine modification|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K11447 histone demethylase [EC:1.14.11.-][-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) X:44873177-45112602 72 78 86 365 410 366 0.484455586042374 0.476972278338002 0.521713970799 2.20043847844042 2.26344866649133 2.30796300090479 0.494380611726459 2.25728338194551 -2.19089347663234 5.02729586320342e-18 3.23458816163955e-16 DOWN ENSG00000147676 MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:13634] GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0045177|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0016324|GO:0031982|GO:0005737|GO:0070062|GO:0016021|GO:0098857|GO:0048471|GO:0045121 cell|membrane|extracellular region|binding|extracellular vesicle|apical part of cell|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|apical plasma membrane|vesicle|cytoplasm|extracellular exosome|integral component of membrane|membrane microdomain|perinuclear region of cytoplasm|membrane raft - - - - 8:119165034-119245673 1749 1767 3807 11694 13627 12936 31.8862714351599 29.2772718806714 62.5764784103248 191.018217598358 203.836618877742 221.025794145367 41.2466739087187 205.293543540489 -2.31533856390851 5.07966423313872e-18 3.26125367776609e-16 DOWN ENSG00000173898 SPTBN2 spectrin, beta, non-erythrocytic 2 [Source:HGNC Symbol;Acc:HGNC:11276] GO:0040011|GO:0032502|GO:0040007|GO:0002376|GO:0045202|GO:0007610|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0005200|GO:0051716|GO:0008021|GO:0048523|GO:0050794|GO:0019882|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0045177|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0008289|GO:0071944|GO:0009605|GO:0009893|GO:0005615|GO:0048589|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0006935|GO:0045087|GO:0021692|GO:0048468|GO:0043025|GO:0030534|GO:0019884|GO:0006810|GO:0016324|GO:0005938|GO:0007275|GO:0048513|GO:0032535|GO:0043168|GO:0021587|GO:0030902|GO:0006952|GO:0005543|GO:0031982|GO:0031325|GO:0051128|GO:0007420|GO:0022607|GO:0043231|GO:0030133|GO:0010243|GO:0005737|GO:0032970|GO:0060322|GO:0006928|GO:0035264|GO:0009966|GO:0036477|GO:0010646|GO:0043085|GO:0021696|GO:0050776|GO:0021695|GO:0007154|GO:0022037|GO:0007165|GO:0050808|GO:0008092|GO:0009725|GO:0002504|GO:0050790|GO:0048002|GO:0030030|GO:0021549|GO:0048869|GO:0030029|GO:0009967|GO:0019538|GO:0043254|GO:0021680|GO:0023014|GO:0010033|GO:0031323|GO:0021575|GO:0005794|GO:0005768|GO:0006996|GO:0071774|GO:0000165|GO:0016192|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0031333|GO:0030864|GO:0007416|GO:0007166|GO:0032956|GO:0043412|GO:0007010|GO:0007417|GO:0031410|GO:0003779|GO:1901652|GO:0000904|GO:0071417|GO:0016023|GO:0051347|GO:0036211|GO:0070382|GO:0043242|GO:0043434|GO:0044344|GO:0051247|GO:0048471|GO:0070848|GO:0031988|GO:0002764|GO:0006461|GO:0043244|GO:0030036|GO:0032270|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0000139|GO:0051246|GO:0030154|GO:0030832|GO:0048858|GO:0008091|GO:1902531|GO:0032870|GO:0005856|GO:0097305|GO:0002495|GO:0048666|GO:0030182|GO:0015629|GO:0007411|GO:0043241|GO:0031401|GO:0008543|GO:0034622|GO:1901653|GO:0043408|GO:0043623|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0008064|GO:0061564|GO:0045471|GO:0051494|GO:0051493|GO:0007167|GO:0019886|GO:0032272|GO:0071375|GO:0043410|GO:1901879|GO:0032868|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0030863|GO:0007015|GO:0048812|GO:0030833|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0051258|GO:0007265|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043624|GO:0043405|GO:0042325|GO:0001932|GO:0071361|GO:0032869|GO:0030837|GO:0038093|GO:0030834|GO:0001934|GO:0042327|GO:0007169|GO:0008154|GO:0030835|GO:0048010|GO:0038095|GO:0051693|GO:0071900|GO:0030042|GO:0030041|GO:0032147|GO:0008286|GO:0038127|GO:0051261|GO:0007173 locomotion|developmental process|growth|immune system process|synapse|behavior|structural molecule activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|structural constituent of cytoskeleton|cellular response to stimulus|synaptic vesicle|negative regulation of cellular process|regulation of cellular process|antigen processing and presentation|intracellular organelle|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|apical part of cell|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|lipid binding|cell periphery|response to external stimulus|positive regulation of metabolic process|extracellular space|developmental growth|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|chemotaxis|innate immune response|cerebellar Purkinje cell layer morphogenesis|cell development|neuronal cell body|adult behavior|antigen processing and presentation of exogenous antigen|transport|apical plasma membrane|cell cortex|multicellular organism development|animal organ development|regulation of cellular component size|anion binding|cerebellum morphogenesis|hindbrain development|defense response|phospholipid binding|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|brain development|cellular component assembly|intracellular membrane-bounded organelle|transport vesicle|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|head development|movement of cell or subcellular component|multicellular organism growth|regulation of signal transduction|somatodendritic compartment|regulation of cell communication|positive regulation of catalytic activity|cerebellar cortex morphogenesis|regulation of immune response|cerebellar cortex development|cell communication|metencephalon development|signal transduction|synapse organization|cytoskeletal protein binding|response to hormone|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|regulation of catalytic activity|antigen processing and presentation of peptide antigen|cell projection organization|cerebellum development|cellular developmental process|actin filament-based process|positive regulation of signal transduction|protein metabolic process|regulation of protein complex assembly|cerebellar Purkinje cell layer development|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|hindbrain morphogenesis|Golgi apparatus|endosome|organelle organization|response to fibroblast growth factor|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|negative regulation of protein complex assembly|cortical actin cytoskeleton|synapse assembly|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|macromolecule modification|cytoskeleton organization|central nervous system development|cytoplasmic vesicle|actin binding|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|protein modification process|exocytic vesicle|negative regulation of protein complex disassembly|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|perinuclear region of cytoplasm|response to growth factor|membrane-bounded vesicle|immune response-regulating signaling pathway|protein complex assembly|regulation of protein complex disassembly|actin cytoskeleton organization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|Golgi membrane|regulation of protein metabolic process|cell differentiation|regulation of actin filament length|cell projection morphogenesis|spectrin|regulation of intracellular signal transduction|cellular response to hormone stimulus|cytoskeleton|response to alcohol|antigen processing and presentation of peptide antigen via MHC class II|neuron development|neuron differentiation|actin cytoskeleton|axon guidance|protein complex disassembly|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular macromolecular complex assembly|cellular response to peptide|regulation of MAPK cascade|cellular protein complex assembly|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|regulation of actin polymerization or depolymerization|axon development|response to ethanol|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class II|negative regulation of protein polymerization|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of protein depolymerization|response to insulin|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|cortical cytoskeleton|actin filament organization|neuron projection morphogenesis|regulation of actin filament polymerization|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|protein polymerization|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|cellular protein complex disassembly|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to ethanol|cellular response to insulin stimulus|negative regulation of actin filament polymerization|Fc receptor signaling pathway|regulation of actin filament depolymerization|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|actin filament capping|regulation of protein serine/threonine kinase activity|actin filament depolymerization|actin filament polymerization|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|protein depolymerization|epidermal growth factor receptor signaling pathway - - - - 11:66685248-66729226 362 500 640 1785 2098 2043 1.93843622137138 2.43328628984485 3.08984748707319 8.56404291215619 9.21756636269393 10.2527458246423 2.48718999942981 9.34478503316414 -1.90964475571731 6.17042031059503e-18 3.95304137237133e-16 DOWN ENSG00000134775 FHOD3 formin homology 2 domain containing 3 [Source:HGNC Symbol;Acc:HGNC:26178] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0030017|GO:0007507|GO:0030018|GO:0009888|GO:0048468|GO:0007275|GO:0048513|GO:0032535|GO:0051128|GO:0022607|GO:0061061|GO:0005737|GO:0032970|GO:0031674|GO:0008092|GO:0048869|GO:0030029|GO:0043254|GO:0006996|GO:0031333|GO:0032956|GO:0007010|GO:0072358|GO:0042692|GO:0035051|GO:0048738|GO:0003779|GO:0055006|GO:0060537|GO:0043292|GO:0006461|GO:0055001|GO:0030036|GO:0070925|GO:0033043|GO:0030154|GO:0030832|GO:0030239|GO:0072359|GO:0005856|GO:0055002|GO:0055003|GO:0030016|GO:0034622|GO:0055013|GO:0043623|GO:0008064|GO:0051494|GO:0051493|GO:0032272|GO:0051146|GO:0031032|GO:0014706|GO:0055007|GO:0007015|GO:0045214|GO:0030833|GO:0051258|GO:0030837|GO:0051639|GO:0008154|GO:0030041 developmental process|cell|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|sarcomere|heart development|Z disc|tissue development|cell development|multicellular organism development|animal organ development|regulation of cellular component size|regulation of cellular component organization|cellular component assembly|muscle structure development|cytoplasm|regulation of actin filament-based process|I band|cytoskeletal protein binding|cellular developmental process|actin filament-based process|regulation of protein complex assembly|organelle organization|negative regulation of protein complex assembly|regulation of actin cytoskeleton organization|cytoskeleton organization|cardiovascular system development|muscle cell differentiation|cardiocyte differentiation|cardiac muscle tissue development|actin binding|cardiac cell development|muscle tissue development|contractile fiber|protein complex assembly|muscle cell development|actin cytoskeleton organization|organelle assembly|regulation of organelle organization|cell differentiation|regulation of actin filament length|myofibril assembly|circulatory system development|cytoskeleton|striated muscle cell development|cardiac myofibril assembly|myofibril|cellular macromolecular complex assembly|cardiac muscle cell development|cellular protein complex assembly|regulation of actin polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|striated muscle cell differentiation|actomyosin structure organization|striated muscle tissue development|cardiac muscle cell differentiation|actin filament organization|sarcomere organization|regulation of actin filament polymerization|protein polymerization|negative regulation of actin filament polymerization|actin filament network formation|actin polymerization or depolymerization|actin filament polymerization - - - - 18:36297714-36780055 28 25 41 217 197 202 0.195847525313707 0.158925440189321 0.258558292231252 1.35994898932985 1.13057604266371 1.32417808447629 0.204443752578093 1.27156770548995 -2.63683239878911 6.19884389603851e-18 3.96274701653819e-16 DOWN ENSG00000006194 ZNF263 zinc finger protein 263 [Source:HGNC Symbol;Acc:HGNC:13056] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0015630|GO:0006351|GO:0006355|GO:1903507|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|microtubule cytoskeleton|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription - - - - 16:3263800-3301401 1297 1318 1108 337 413 398 7.01795341352207 6.4813574419678 5.40536062164825 1.63379560690467 1.83353227202841 2.01828508740157 6.30155715904604 1.82853765544488 1.78501803605175 6.25526666055078e-18 3.99027202743767e-16 UP ENSG00000147459 DOCK5 dedicator of cytokinesis 5 [Source:HGNC Symbol;Acc:HGNC:23476] GO:0040011|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0040012|GO:0048870|GO:0040017|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0019222|GO:0051272|GO:2000147|GO:0005737|GO:0003012|GO:0006928|GO:0043085|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0045932|GO:0050790|GO:2000145|GO:0003013|GO:0035150|GO:0006936|GO:0051345|GO:0090257|GO:0030334|GO:0045906|GO:0035556|GO:0045986|GO:0030335|GO:0008015|GO:0006939|GO:0006937|GO:1904694|GO:0014909|GO:0043087|GO:0014910|GO:0019229|GO:0043547|GO:0014911|GO:0007264|GO:0050880|GO:0003056|GO:0006940|GO:0014829|GO:0042310 locomotion|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of locomotion|cell motility|positive regulation of locomotion|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|positive regulation of cellular component movement|positive regulation of cell motility|cytoplasm|muscle system process|movement of cell or subcellular component|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of muscle contraction|regulation of catalytic activity|regulation of cell motility|circulatory system process|regulation of tube size|muscle contraction|positive regulation of hydrolase activity|regulation of muscle system process|regulation of cell migration|negative regulation of vasoconstriction|intracellular signal transduction|negative regulation of smooth muscle contraction|positive regulation of cell migration|blood circulation|smooth muscle contraction|regulation of muscle contraction|negative regulation of vascular smooth muscle contraction|smooth muscle cell migration|regulation of GTPase activity|regulation of smooth muscle cell migration|regulation of vasoconstriction|positive regulation of GTPase activity|positive regulation of smooth muscle cell migration|small GTPase mediated signal transduction|regulation of blood vessel size|regulation of vascular smooth muscle contraction|regulation of smooth muscle contraction|vascular smooth muscle contraction|vasoconstriction - - - - 8:25184723-25418082 299 436 733 2141 2647 2566 1.00233619758591 1.32834105283115 2.21544368840561 6.43068200460034 7.28055764924165 8.06173116035242 1.51537364627422 7.2576569380648 -2.25983030028371 6.44848042935449e-18 4.10475340592642e-16 DOWN ENSG00000118985 ELL2 elongation factor, RNA polymerase II, 2 [Source:HGNC Symbol;Acc:HGNC:17064] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0019222|GO:0008023|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0005813|GO:0010468|GO:0034645|GO:0051252|GO:0005815|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0032774|GO:0034660|GO:2001141|GO:0015630|GO:0006351|GO:0006355|GO:0006366|GO:1903506|GO:0006354|GO:0016073|GO:0006368|GO:0009301|GO:0042795 macromolecular complex|cell|cellular process|metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|regulation of metabolic process|transcription elongation factor complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|centrosome|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|microtubule organizing center|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|microtubule cytoskeleton|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|DNA-templated transcription, elongation|snRNA metabolic process|transcription elongation from RNA polymerase II promoter|snRNA transcription|snRNA transcription from RNA polymerase II promoter - - - - 5:95885098-95962071 483 466 838 2510 2737 2328 3.70120984034913 3.24536275789862 5.78968755907458 17.2332958632156 17.2083707839488 16.7189478220873 4.24542005244078 17.0535381564172 -2.00609188142746 6.69384777478512e-18 4.25187513762628e-16 DOWN ENSG00000071054 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6866] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0048468|GO:0010941|GO:0007275|GO:0043168|GO:0001882|GO:0016772|GO:0033554|GO:0005737|GO:0009966|GO:0060548|GO:0010646|GO:0007154|GO:0007165|GO:0008219|GO:0000166|GO:0030030|GO:0048869|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:0032268|GO:0000902|GO:0031175|GO:0035639|GO:0043412|GO:0043069|GO:0001883|GO:0036211|GO:0000278|GO:0032549|GO:0031098|GO:0007346|GO:0016301|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0017076|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0016773|GO:0043067|GO:0048666|GO:0030182|GO:0004111|GO:0043408|GO:0005524|GO:0030554|GO:0016310|GO:0032872|GO:0042981|GO:0043066|GO:0004672|GO:0022008|GO:0006464|GO:0048812|GO:0051403|GO:0006915|GO:0046328|GO:0006468|GO:0048699|GO:0042325|GO:0007254|GO:0001932|GO:0004674 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|cell development|regulation of cell death|multicellular organism development|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular response to stress|cytoplasm|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|cell communication|signal transduction|cell death|nucleotide binding|cell projection organization|cellular developmental process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|purine ribonucleoside triphosphate binding|macromolecule modification|negative regulation of programmed cell death|purine nucleoside binding|protein modification process|mitotic cell cycle|ribonucleoside binding|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|kinase activity|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|regulation of programmed cell death|neuron development|neuron differentiation|creatine kinase activity|regulation of MAPK cascade|ATP binding|adenyl nucleotide binding|phosphorylation|regulation of stress-activated MAPK cascade|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|neurogenesis|cellular protein modification process|neuron projection morphogenesis|stress-activated MAPK cascade|apoptotic process|regulation of JNK cascade|protein phosphorylation|generation of neurons|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity K04407 mitogen-activated protein kinase kinase kinase kinase 4[2.7.11.1] hsa04010 MAPK signaling pathway - Homo sapiens (human) 2:101696850-101894689 345 458 750 2515 2578 2066 1.22333143434371 1.47594592217803 2.39772774468966 7.9902496584031 7.50024411110566 6.86568529938662 1.6990017004038 7.45205968963179 -2.13295193364011 6.72537399189463e-18 4.26283047036141e-16 DOWN ENSG00000138674 SEC31A SEC31 homolog A, COPII coat complex component [Source:HGNC Symbol;Acc:HGNC:17052] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0019882|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006486|GO:0051640|GO:0019884|GO:0006810|GO:0031982|GO:0033554|GO:0022607|GO:0030117|GO:0051668|GO:0043231|GO:0030133|GO:0005737|GO:0012506|GO:0006903|GO:0005975|GO:0051656|GO:0045184|GO:0048306|GO:0030658|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0005783|GO:0051649|GO:0002504|GO:0048002|GO:0010035|GO:0044249|GO:0019538|GO:0010033|GO:0005794|GO:0006996|GO:0016192|GO:0051650|GO:0012507|GO:0005829|GO:0034645|GO:0006900|GO:0016050|GO:0030968|GO:0043412|GO:0006487|GO:0090114|GO:0031410|GO:0015031|GO:0010038|GO:0016023|GO:0009100|GO:0036211|GO:0046907|GO:0048199|GO:0006986|GO:0048471|GO:0031988|GO:0070085|GO:0006461|GO:0002474|GO:0030659|GO:1901137|GO:0044267|GO:0071310|GO:0000139|GO:0051648|GO:0009059|GO:0030120|GO:0035967|GO:0070971|GO:0034976|GO:0030134|GO:0002495|GO:0034620|GO:0009101|GO:0043413|GO:0036498|GO:0048208|GO:0051592|GO:0018279|GO:0048193|GO:0030135|GO:0019886|GO:0030127|GO:0006464|GO:0018193|GO:0043687|GO:0006888 macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|antigen processing and presentation|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|protein glycosylation|organelle localization|antigen processing and presentation of exogenous antigen|transport|vesicle|cellular response to stress|cellular component assembly|membrane coat|localization within membrane|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|vesicle membrane|vesicle targeting|carbohydrate metabolic process|establishment of organelle localization|establishment of protein localization|calcium-dependent protein binding|transport vesicle membrane|protein localization|cell communication|membrane organization|signal transduction|endoplasmic reticulum|establishment of localization in cell|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|antigen processing and presentation of peptide antigen|response to inorganic substance|cellular biosynthetic process|protein metabolic process|response to organic substance|Golgi apparatus|organelle organization|vesicle-mediated transport|establishment of vesicle localization|ER to Golgi transport vesicle membrane|cytosol|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|endoplasmic reticulum unfolded protein response|macromolecule modification|protein N-linked glycosylation|COPII-coated vesicle budding|cytoplasmic vesicle|protein transport|response to metal ion|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|protein modification process|intracellular transport|vesicle targeting, to, from or within Golgi|response to unfolded protein|perinuclear region of cytoplasm|membrane-bounded vesicle|glycosylation|protein complex assembly|antigen processing and presentation of peptide antigen via MHC class I|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular protein metabolic process|cellular response to organic substance|Golgi membrane|vesicle localization|macromolecule biosynthetic process|vesicle coat|cellular response to topologically incorrect protein|endoplasmic reticulum exit site|response to endoplasmic reticulum stress|ER to Golgi transport vesicle|antigen processing and presentation of peptide antigen via MHC class II|cellular response to unfolded protein|glycoprotein biosynthetic process|macromolecule glycosylation|IRE1-mediated unfolded protein response|COPII vesicle coating|response to calcium ion|protein N-linked glycosylation via asparagine|Golgi vesicle transport|coated vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class II|COPII vesicle coat|cellular protein modification process|peptidyl-amino acid modification|post-translational protein modification|ER to Golgi vesicle-mediated transport K14005 protein transport protein SEC31[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 4:82818661-82901166 408 400 631 1772 1904 2019 1.59936929353446 1.425047474699 2.23014221171756 6.22372334967029 6.12383860865242 7.4174398949409 1.75151965998367 6.58833395108787 -1.91130650279435 7.66888646585437e-18 4.85057068965289e-16 DOWN ENSG00000125944 HNRNPR heterogeneous nuclear ribonucleoprotein R [Source:HGNC Symbol;Acc:HGNC:5047] GO:0032991|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0019013|GO:0043229|GO:0006807|GO:0007623|GO:0019028|GO:0071704|GO:0009056|GO:0044237|GO:0030427|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0030426|GO:0043231|GO:0005737|GO:0030529|GO:0043005|GO:0009890|GO:0036477|GO:0006139|GO:0044092|GO:0044306|GO:0050790|GO:0000166|GO:0043086|GO:0044249|GO:0019538|GO:0043487|GO:0031324|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0030424|GO:0010629|GO:0051252|GO:0044265|GO:0032269|GO:0043679|GO:0031981|GO:0030425|GO:0005681|GO:0005654|GO:0043603|GO:0044267|GO:0010467|GO:0050779|GO:0019439|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0043488|GO:0006401|GO:0043043|GO:0006396|GO:0017148|GO:0010608|GO:0061157|GO:0006412|GO:0016071|GO:0006417|GO:0044822|GO:0061014|GO:0071013|GO:0003729|GO:0006402|GO:0006397|GO:0008380|GO:0000375|GO:0003730|GO:0000398 macromolecular complex|cell|rhythmic process|cellular process|metabolic process|binding|small molecule binding|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|viral nucleocapsid|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|viral capsid|organic substance metabolic process|catabolic process|cellular metabolic process|site of polarized growth|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|growth cone|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|neuron projection|negative regulation of biosynthetic process|somatodendritic compartment|nucleobase-containing compound metabolic process|negative regulation of molecular function|neuron projection terminus|regulation of catalytic activity|nucleotide binding|negative regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|regulation of RNA stability|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|axon|negative regulation of gene expression|regulation of RNA metabolic process|cellular macromolecule catabolic process|negative regulation of cellular protein metabolic process|axon terminus|nuclear lumen|dendrite|spliceosomal complex|nucleoplasm|cellular amide metabolic process|cellular protein metabolic process|gene expression|RNA destabilization|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulation of mRNA stability|RNA catabolic process|peptide biosynthetic process|RNA processing|negative regulation of translation|posttranscriptional regulation of gene expression|mRNA destabilization|translation|mRNA metabolic process|regulation of translation|poly(A) RNA binding|positive regulation of mRNA catabolic process|catalytic step 2 spliceosome|mRNA binding|mRNA catabolic process|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|mRNA 3'-UTR binding|mRNA splicing, via spliceosome - - - - 1:23303771-23344336 985 922 724 4693 4678 3329 4.18749763567306 3.56229060437633 2.77505307862572 17.8758523218757 16.317239490282 13.2635951346434 3.50828043955837 15.8188956489337 -2.17281290423269 7.87740906143652e-18 4.97192748668342e-16 DOWN ENSG00000173482 PTPRM protein tyrosine phosphatase, receptor type, M [Source:HGNC Symbol;Acc:HGNC:9675] GO:0040011|GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0040013|GO:0042995|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0071704|GO:0044237|GO:0038023|GO:0048870|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0031252|GO:0016787|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0042802|GO:0048514|GO:0042127|GO:0006935|GO:0060041|GO:0009888|GO:0048468|GO:0001568|GO:0007275|GO:0010632|GO:0048513|GO:0016788|GO:0005912|GO:0098609|GO:0005887|GO:0004888|GO:0005737|GO:0007423|GO:0006928|GO:0009887|GO:0003407|GO:0048729|GO:0030027|GO:0050673|GO:1903524|GO:0050839|GO:0042493|GO:0031226|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0005913|GO:0051271|GO:0010842|GO:0008285|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0010633|GO:0019538|GO:2000146|GO:0003013|GO:0016525|GO:0000902|GO:0031175|GO:0098742|GO:0035150|GO:0090132|GO:0001654|GO:0001944|GO:0043412|GO:0072358|GO:0000904|GO:0030334|GO:0001935|GO:0001667|GO:0036211|GO:0045765|GO:0060042|GO:0048471|GO:0050678|GO:0050680|GO:0030336|GO:0045296|GO:0006796|GO:1901342|GO:0044267|GO:0032990|GO:0007399|GO:0097485|GO:0010594|GO:0030154|GO:0048858|GO:0072359|GO:0008015|GO:0010596|GO:0045909|GO:0042578|GO:0048666|GO:0030182|GO:0007411|GO:0016311|GO:0042312|GO:0043010|GO:0061564|GO:0001936|GO:0007156|GO:0001937|GO:0010631|GO:0016791|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0005001|GO:0048592|GO:0050880|GO:0006470|GO:0007409|GO:0048593|GO:0048699|GO:0042311|GO:0004721|GO:0031290|GO:0043542|GO:0035335|GO:0004725 locomotion|developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of locomotion|cell projection|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|organic substance metabolic process|cellular metabolic process|signaling receptor activity|cell motility|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|cell leading edge|hydrolase activity|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|identical protein binding|blood vessel morphogenesis|regulation of cell proliferation|chemotaxis|retina development in camera-type eye|tissue development|cell development|blood vessel development|multicellular organism development|regulation of epithelial cell migration|animal organ development|hydrolase activity, acting on ester bonds|adherens junction|cell-cell adhesion|integral component of plasma membrane|transmembrane signaling receptor activity|cytoplasm|sensory organ development|movement of cell or subcellular component|organ morphogenesis|neural retina development|tissue morphogenesis|lamellipodium|epithelial cell proliferation|positive regulation of blood circulation|cell adhesion molecule binding|response to drug|intrinsic component of plasma membrane|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|cell-cell adherens junction|negative regulation of cellular component movement|retina layer formation|negative regulation of cell proliferation|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|negative regulation of epithelial cell migration|protein metabolic process|negative regulation of cell motility|circulatory system process|negative regulation of angiogenesis|cell morphogenesis|neuron projection development|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of tube size|epithelium migration|eye development|vasculature development|macromolecule modification|cardiovascular system development|cell morphogenesis involved in differentiation|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|protein modification process|regulation of angiogenesis|retina morphogenesis in camera-type eye|perinuclear region of cytoplasm|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of cell migration|cadherin binding|phosphate-containing compound metabolic process|regulation of vasculature development|cellular protein metabolic process|cell part morphogenesis|nervous system development|neuron projection guidance|regulation of endothelial cell migration|cell differentiation|cell projection morphogenesis|circulatory system development|blood circulation|negative regulation of endothelial cell migration|positive regulation of vasodilation|phosphoric ester hydrolase activity|neuron development|neuron differentiation|axon guidance|dephosphorylation|regulation of vasodilation|camera-type eye development|axon development|regulation of endothelial cell proliferation|homophilic cell adhesion via plasma membrane adhesion molecules|negative regulation of endothelial cell proliferation|epithelial cell migration|phosphatase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|transmembrane receptor protein tyrosine phosphatase activity|eye morphogenesis|regulation of blood vessel size|protein dephosphorylation|axonogenesis|camera-type eye morphogenesis|generation of neurons|vasodilation|phosphoprotein phosphatase activity|retinal ganglion cell axon guidance|endothelial cell migration|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity K05693 receptor-type tyrosine-protein phosphatase mu[3.1.3.48] hsa04514|hsa04520 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Adherens junction - Homo sapiens (human) 18:7566782-8406861 35 28 95 454 479 627 0.163417431987401 0.118814815723693 0.399917364277455 1.89927031751302 1.83500032301489 2.74365548457815 0.227383203996183 2.15930870836869 -3.24737191844231 8.0971703999731e-18 5.09985074094509e-16 DOWN ENSG00000132182 NUP210 nucleoporin 210kDa [Source:HGNC Symbol;Acc:HGNC:30052] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0016032|GO:0007049|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0034641|GO:0044281|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0009408|GO:0005975|GO:0005635|GO:0046983|GO:0045184|GO:0016458|GO:0006139|GO:0008104|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0005783|GO:0006403|GO:0031965|GO:0016021|GO:0044249|GO:0009266|GO:0019538|GO:0010033|GO:0010256|GO:0006996|GO:0051701|GO:1900034|GO:0019048|GO:0006998|GO:0010468|GO:0019054|GO:0007166|GO:1903047|GO:0043412|GO:0034097|GO:0031047|GO:0010629|GO:0015031|GO:0036211|GO:0000278|GO:0019083|GO:0034605|GO:0050658|GO:0044267|GO:0010467|GO:0019058|GO:0071310|GO:0006997|GO:0009059|GO:0016070|GO:0008643|GO:0005634|GO:0005643|GO:0010827|GO:0007077|GO:0019221|GO:0051028|GO:0006396|GO:0032774|GO:0034660|GO:0051081|GO:0071345|GO:0006464|GO:0008645|GO:0006399|GO:0018193|GO:0043687|GO:0008033|GO:0032446|GO:0015758|GO:0018205|GO:0016925 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|viral process|cell cycle|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|response to heat|carbohydrate metabolic process|nuclear envelope|protein dimerization activity|establishment of protein localization|gene silencing|nucleobase-containing compound metabolic process|protein localization|cell communication|transmembrane transport|membrane organization|signal transduction|endoplasmic reticulum|RNA localization|nuclear membrane|integral component of membrane|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|response to organic substance|endomembrane system organization|organelle organization|interaction with host|regulation of cellular response to heat|modulation by virus of host morphology or physiology|nuclear envelope organization|regulation of gene expression|modulation by virus of host process|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|response to cytokine|gene silencing by RNA|negative regulation of gene expression|protein transport|protein modification process|mitotic cell cycle|viral transcription|cellular response to heat|RNA transport|cellular protein metabolic process|gene expression|viral life cycle|cellular response to organic substance|nucleus organization|macromolecule biosynthetic process|RNA metabolic process|carbohydrate transport|nucleus|nuclear pore|regulation of glucose transport|mitotic nuclear envelope disassembly|cytokine-mediated signaling pathway|mRNA transport|RNA processing|RNA biosynthetic process|ncRNA metabolic process|nuclear envelope disassembly|cellular response to cytokine stimulus|cellular protein modification process|hexose transport|tRNA metabolic process|peptidyl-amino acid modification|post-translational protein modification|tRNA processing|protein modification by small protein conjugation|glucose transport|peptidyl-lysine modification|protein sumoylation K14314 nuclear pore complex protein Nup210[-] hsa03013 RNA transport - Homo sapiens (human) 3:13316235-13420309 1002 1019 1576 4197 4871 4687 7.95938721184798 7.35641236300341 11.2870978956794 29.8709145311965 31.7466509523437 34.8927888094707 8.86763249017693 32.1701180976703 -1.85910034662769 8.52432833959468e-18 5.35758522632126e-16 DOWN ENSG00000145996 CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 [Source:HGNC Symbol;Acc:HGNC:21050] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0006725|GO:1901360|GO:0051536|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0005783|GO:0016021|GO:0044249|GO:0019538|GO:0051539|GO:0034645|GO:0006518|GO:0046872|GO:0043412|GO:0005791|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0043043|GO:1990145|GO:0006396|GO:0034660|GO:0009451|GO:0006412|GO:0061712|GO:0006400|GO:0006399|GO:0035598|GO:0008033|GO:0035600 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|iron-sulfur cluster binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|protein metabolic process|4 iron, 4 sulfur cluster binding|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|macromolecule modification|rough endoplasmic reticulum|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|peptide biosynthetic process|maintenance of translational fidelity|RNA processing|ncRNA metabolic process|RNA modification|translation|tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase|tRNA modification|tRNA metabolic process|N6-threonylcarbomyladenosine methylthiotransferase activity|tRNA processing|tRNA methylthiolation - - - - 6:20534457-21232404 40 51 67 289 303 272 0.517460687605047 0.5996128073684 0.781461112152377 3.34975444044638 3.21608340551363 3.2977284708764 0.632844869041941 3.28785543894547 -2.37722307131876 8.57866792581274e-18 5.38041076170617e-16 DOWN ENSG00000257093 KIAA1147 KIAA1147 [Source:HGNC Symbol;Acc:HGNC:29472] - - - - - - 7:141656728-141702153 130 319 307 1284 1357 1666 1.09760811040282 2.44780135926009 2.3369970578107 9.71332748437071 9.40054891893534 13.1828531390675 1.96080217582454 10.7655765141245 -2.45690968490631 9.30744910693827e-18 5.82525336768417e-16 DOWN ENSG00000163584 RPL22L1 ribosomal protein L22 like 1 [Source:HGNC Symbol;Acc:HGNC:27610] GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003735|GO:0009058|GO:0005622|GO:0034641|GO:0005737|GO:0030529|GO:0044249|GO:0019538|GO:0005829|GO:0034645|GO:0006518|GO:0005840|GO:0015934|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0043043|GO:0022626|GO:0006412|GO:0022625|GO:0002181 macromolecular complex|structural molecule activity|cell|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|structural constituent of ribosome|biosynthetic process|intracellular|cellular nitrogen compound metabolic process|cytoplasm|intracellular ribonucleoprotein complex|cellular biosynthetic process|protein metabolic process|cytosol|cellular macromolecule biosynthetic process|peptide metabolic process|ribosome|large ribosomal subunit|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|peptide biosynthetic process|cytosolic ribosome|translation|cytosolic large ribosomal subunit|cytoplasmic translation K02891 large subunit ribosomal protein L22e[-] hsa03010 Ribosome - Homo sapiens (human) 3:170864875-170870483 2095 2123 2424 755 467 608 32.4772602773538 29.9106058376406 33.8799020685534 10.4867211711052 5.93991779328446 8.83340135780879 32.0892560611826 8.42001344073282 1.93019590203994 9.92474486825105e-18 6.1856645782206e-16 UP ENSG00000164684 ZNF704 zinc finger protein 704 [Source:HGNC Symbol;Acc:HGNC:32291] GO:0005488|GO:0043167|GO:0043169|GO:0046872 binding|ion binding|cation binding|metal ion binding - - - - 8:80628451-80874781 70 104 229 844 977 1252 0.313865884205011 0.423800672935042 0.92576107957035 3.39069753360999 3.59427638577659 5.26116821069742 0.554475878903468 4.08204737669467 -2.88009632054779 9.90411281079816e-18 6.1856645782206e-16 DOWN ENSG00000196367 TRRAP transformation/transcription domain-associated protein [Source:HGNC Symbol;Acc:HGNC:12347] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0000989|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0006281|GO:0003712|GO:0006725|GO:1901360|GO:0016570|GO:0034641|GO:0016772|GO:0046483|GO:0033554|GO:0070603|GO:0043231|GO:0005737|GO:0005667|GO:0006139|GO:0000790|GO:0044249|GO:0019538|GO:0005794|GO:0006996|GO:0051276|GO:0034645|GO:0016578|GO:0044798|GO:0043412|GO:0006325|GO:0000812|GO:0016573|GO:0036211|GO:0031981|GO:1990234|GO:0006508|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0016301|GO:0006796|GO:0044267|GO:0010467|GO:0000123|GO:0009059|GO:0016070|GO:0016773|GO:0005634|GO:0006974|GO:0032774|GO:0043968|GO:0043967|GO:0016310|GO:0070646|GO:0016568|GO:0090575|GO:0070461|GO:0006464|GO:0016591|GO:0006351|GO:0033276|GO:0000125|GO:0016579|GO:0018193|GO:0043189|GO:0030914|GO:0035267|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|transferase activity|DNA repair|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|cytoplasm|transcription factor complex|nucleobase-containing compound metabolic process|nuclear chromatin|cellular biosynthetic process|protein metabolic process|Golgi apparatus|organelle organization|chromosome organization|cellular macromolecule biosynthetic process|histone deubiquitination|nuclear transcription factor complex|macromolecule modification|chromatin organization|Swr1 complex|histone acetylation|protein modification process|nuclear lumen|transferase complex|proteolysis|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|histone acetyltransferase complex|macromolecule biosynthetic process|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|cellular response to DNA damage stimulus|RNA biosynthetic process|histone H2A acetylation|histone H4 acetylation|phosphorylation|protein modification by small protein removal|chromatin modification|RNA polymerase II transcription factor complex|SAGA-type complex|cellular protein modification process|DNA-directed RNA polymerase II, holoenzyme|transcription, DNA-templated|transcription factor TFTC complex|PCAF complex|protein deubiquitination|peptidyl-amino acid modification|H4/H2A histone acetyltransferase complex|STAGA complex|NuA4 histone acetyltransferase complex|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation K08874 transformation/transcription domain-associated protein[-] hsa05166 HTLV-I infection - Homo sapiens (human) 7:98877933-99013243 678 763 775 2435 2995 2518 3.13052275137849 3.20178216451068 3.22628516348271 10.0735737900366 11.3462357672104 10.8961129462117 3.18619669312396 10.7719741678196 -1.75737543878502 1.0543212963989e-17 6.55743916306102e-16 DOWN ENSG00000151612 ZNF827 zinc finger protein 827 [Source:HGNC Symbol;Acc:HGNC:27193] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 4:145757627-145938635 51 31 57 300 305 288 0.289579175046449 0.159972450562612 0.291800356500406 1.52621725798121 1.42090322645435 1.5325647967809 0.247117327369822 1.49322842707215 -2.59516680086705 1.06155977847098e-17 6.58873297847665e-16 DOWN ENSG00000107099 DOCK8 dedicator of cytokinesis 8 [Source:HGNC Symbol;Acc:HGNC:19191] GO:0040011|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0006950|GO:0050900|GO:0048870|GO:0007155|GO:0009893|GO:0031252|GO:0005622|GO:0005515|GO:0005085|GO:0019222|GO:0036336|GO:0050817|GO:0016337|GO:0070661|GO:0010941|GO:0070489|GO:0098609|GO:0005737|GO:0009611|GO:0006928|GO:0001775|GO:0008037|GO:0060548|GO:0043085|GO:0046649|GO:0007154|GO:0016477|GO:0007165|GO:0008219|GO:0050790|GO:0050878|GO:0005829|GO:0001771|GO:0032943|GO:0051345|GO:0043069|GO:0007596|GO:0009988|GO:0042060|GO:0007599|GO:0007159|GO:0042110|GO:0012501|GO:0035556|GO:0046651|GO:0043067|GO:0042098|GO:0043087|GO:0070486|GO:0043547|GO:0042981|GO:0043066|GO:0007264|GO:0006915|GO:2000107|GO:0071593|GO:0061485|GO:0070228|GO:0070231|GO:0070233|GO:0070232 locomotion|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|response to stress|leukocyte migration|cell motility|cell adhesion|positive regulation of metabolic process|cell leading edge|intracellular|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|dendritic cell migration|coagulation|single organismal cell-cell adhesion|leukocyte proliferation|regulation of cell death|T cell aggregation|cell-cell adhesion|cytoplasm|response to wounding|movement of cell or subcellular component|cell activation|cell recognition|negative regulation of cell death|positive regulation of catalytic activity|lymphocyte activation|cell communication|cell migration|signal transduction|cell death|regulation of catalytic activity|regulation of body fluid levels|cytosol|immunological synapse formation|mononuclear cell proliferation|positive regulation of hydrolase activity|negative regulation of programmed cell death|blood coagulation|cell-cell recognition|wound healing|hemostasis|leukocyte cell-cell adhesion|T cell activation|programmed cell death|intracellular signal transduction|lymphocyte proliferation|regulation of programmed cell death|T cell proliferation|regulation of GTPase activity|leukocyte aggregation|positive regulation of GTPase activity|regulation of apoptotic process|negative regulation of apoptotic process|small GTPase mediated signal transduction|apoptotic process|negative regulation of leukocyte apoptotic process|lymphocyte aggregation|memory T cell proliferation|regulation of lymphocyte apoptotic process|T cell apoptotic process|negative regulation of T cell apoptotic process|regulation of T cell apoptotic process - - - - 9:214854-465259 28 24 38 193 193 261 0.101102910847244 0.0787593287339289 0.12371103764785 0.624404685285391 0.571790650935098 0.883244796469979 0.101191092409674 0.693146710896823 -2.77607844549404 1.09233352484068e-17 6.75912478527176e-16 DOWN ENSG00000184384 MAML2 mastermind like transcriptional coactivator 2 [Source:HGNC Symbol;Acc:HGNC:16259] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0000988|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0012505|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0031323|GO:0005794|GO:0003713|GO:0010468|GO:0034645|GO:0007166|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0016604|GO:0007219|GO:0006351|GO:0006355|GO:0016607|GO:0045944|GO:0006366|GO:0006352|GO:0007221|GO:0006357|GO:1903506|GO:0006367 signaling|cell|cellular process|metabolic process|response to stimulus|transcription factor activity, protein binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|endomembrane system|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|Golgi apparatus|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear body|Notch signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|positive regulation of transcription of Notch receptor target|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription initiation from RNA polymerase II promoter K06061 mastermind[-] hsa04330 Notch signaling pathway - Homo sapiens (human) 11:95976598-96343180 14 12 64 415 512 657 0.0995913256459381 0.0775792060487564 0.410464785909311 2.6450309971816 2.98828717870819 4.38005179200444 0.195878439201335 3.33778998929808 -4.0908626738654 1.093540989913e-17 6.75912478527176e-16 DOWN ENSG00000085465 OVGP1 oviductal glycoprotein 1 [Source:HGNC Symbol;Acc:HGNC:8524] GO:0000003|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0048523|GO:0050794|GO:0098595|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0009056|GO:0019953|GO:0043227|GO:0071944|GO:0032504|GO:0016787|GO:0005622|GO:0012505|GO:0016798|GO:0031982|GO:0043231|GO:0030133|GO:0005737|GO:0035805|GO:0005975|GO:2000360|GO:0008037|GO:0035036|GO:0007565|GO:0008061|GO:0009566|GO:0005829|GO:0007339|GO:0031410|GO:0016023|GO:0009988|GO:0007338|GO:0006040|GO:0031988|GO:0004553|GO:0006030|GO:0004568|GO:0006032 reproduction|cell|cellular process|extracellular region|reproductive process|metabolic process|binding|catalytic activity|negative regulation of cellular process|regulation of cellular process|perivitelline space|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|catabolic process|sexual reproduction|membrane-bounded organelle|cell periphery|multicellular organism reproduction|hydrolase activity|intracellular|endomembrane system|hydrolase activity, acting on glycosyl bonds|vesicle|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|egg coat|carbohydrate metabolic process|negative regulation of binding of sperm to zona pellucida|cell recognition|sperm-egg recognition|female pregnancy|chitin binding|fertilization|cytosol|binding of sperm to zona pellucida|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|cell-cell recognition|single fertilization|amino sugar metabolic process|membrane-bounded vesicle|hydrolase activity, hydrolyzing O-glycosyl compounds|chitin metabolic process|chitinase activity|chitin catabolic process - - - - 1:111414314-111427777 188 207 182 15 25 39 4.25824725673875 4.2611277473664 3.71670564253384 0.304412657699807 0.464598576615608 0.827888777932441 4.07869354887966 0.532300004082619 2.93779563240677 1.16927249255393e-17 7.19741463767115e-16 UP ENSG00000156299 TIAM1 T-cell lymphoma invasion and metastasis 1 [Source:HGNC Symbol;Acc:HGNC:11805] GO:0040011|GO:0032502|GO:0040007|GO:0004871|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0042995|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0016049|GO:0005057|GO:0048520|GO:0071704|GO:0044237|GO:0051641|GO:0050795|GO:0048870|GO:0023051|GO:0005911|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0030427|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0031252|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0005085|GO:0048856|GO:0019222|GO:0060341|GO:0051272|GO:0009898|GO:0006935|GO:0045595|GO:0048468|GO:0043025|GO:0006810|GO:0051130|GO:0010941|GO:0061178|GO:0007275|GO:0044291|GO:0005102|GO:0016358|GO:0005874|GO:0032940|GO:0031325|GO:0051128|GO:2000147|GO:0030426|GO:0033554|GO:0010942|GO:0045597|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0003012|GO:0007267|GO:0050920|GO:0032880|GO:0001726|GO:0005088|GO:0006928|GO:0032403|GO:0042592|GO:0031234|GO:0098562|GO:0043005|GO:0031589|GO:0009966|GO:0045184|GO:0046883|GO:0019897|GO:0043197|GO:0019725|GO:0036477|GO:0010646|GO:0043085|GO:0008104|GO:0007154|GO:0060996|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0051649|GO:0008092|GO:0008219|GO:0031256|GO:0050790|GO:0030030|GO:0031253|GO:0010817|GO:0048869|GO:2000145|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0050921|GO:0060560|GO:0000165|GO:1902533|GO:0015631|GO:0032268|GO:0000902|GO:0060998|GO:0005829|GO:0031175|GO:0009743|GO:0031344|GO:1904268|GO:0007166|GO:0090276|GO:0060997|GO:0030424|GO:0043412|GO:0044309|GO:0050773|GO:0051345|GO:0010720|GO:0097061|GO:0048878|GO:0048813|GO:0051223|GO:0044295|GO:0015031|GO:0031346|GO:0000904|GO:0008017|GO:0030334|GO:0030971|GO:0051347|GO:0036211|GO:0070201|GO:0007160|GO:0042886|GO:0055082|GO:0044304|GO:0060999|GO:0051046|GO:0043279|GO:0072657|GO:0031098|GO:0060326|GO:0050769|GO:0030425|GO:0009914|GO:0009306|GO:0051247|GO:0070848|GO:0022604|GO:0034613|GO:0032587|GO:0035773|GO:0019900|GO:0032270|GO:0012501|GO:0014070|GO:0006796|GO:0035556|GO:0060359|GO:0044267|GO:0051174|GO:0014896|GO:0032990|GO:0007399|GO:0046903|GO:0071310|GO:0097485|GO:0051246|GO:0010770|GO:0051020|GO:0030154|GO:0048858|GO:1900006|GO:0030335|GO:0005089|GO:0043068|GO:1902531|GO:0005856|GO:0005634|GO:0042220|GO:0043067|GO:1990138|GO:0051960|GO:0097190|GO:0048666|GO:0008347|GO:0030182|GO:0050796|GO:0071322|GO:0002790|GO:0007411|GO:0070304|GO:0030073|GO:0010975|GO:0031401|GO:0001678|GO:0061003|GO:0043065|GO:0043408|GO:0010769|GO:0030676|GO:1903975|GO:0034284|GO:0050708|GO:0071363|GO:0043087|GO:0016310|GO:0015833|GO:0038179|GO:0050775|GO:0070371|GO:0061564|GO:0043547|GO:0007167|GO:0015630|GO:0048814|GO:0031267|GO:0043410|GO:0014015|GO:0032872|GO:0042981|GO:0051056|GO:0019901|GO:0050772|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050767|GO:0048812|GO:0051403|GO:0046879|GO:0010976|GO:0061001|GO:0043549|GO:0006915|GO:0033500|GO:0033674|GO:0045666|GO:0048011|GO:0003300|GO:0071333|GO:0042593|GO:0030072|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0043406|GO:0090630|GO:0017016|GO:0046328|GO:0007409|GO:0006468|GO:0048699|GO:0014013|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:1990782|GO:0042063|GO:0032874|GO:0001934|GO:0070372|GO:0050770|GO:0045664|GO:0042327|GO:1900149|GO:0007169|GO:0046330|GO:0017048|GO:0043507|GO:0048013|GO:0071902|GO:0016601|GO:0009749|GO:0035023|GO:0071900|GO:0043506|GO:0007266|GO:0048365 locomotion|developmental process|growth|signal transducer activity|synapse|behavior|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|cell projection|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|cell growth|receptor signaling protein activity|positive regulation of behavior|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of behavior|cell motility|regulation of signaling|cell-cell junction|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|cell leading edge|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cellular component movement|cytoplasmic side of plasma membrane|chemotaxis|regulation of cell differentiation|cell development|neuronal cell body|transport|positive regulation of cellular component organization|regulation of cell death|regulation of insulin secretion involved in cellular response to glucose stimulus|multicellular organism development|cell-cell contact zone|receptor binding|dendrite development|microtubule|secretion by cell|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|growth cone|cellular response to stress|positive regulation of cell death|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|muscle system process|cell-cell signaling|regulation of chemotaxis|regulation of protein localization|ruffle|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|protein complex binding|homeostatic process|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|neuron projection|cell-substrate adhesion|regulation of signal transduction|establishment of protein localization|regulation of hormone secretion|extrinsic component of plasma membrane|dendritic spine|cellular homeostasis|somatodendritic compartment|regulation of cell communication|positive regulation of catalytic activity|protein localization|cell communication|dendritic spine development|membrane organization|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|establishment of localization in cell|cytoskeletal protein binding|cell death|leading edge membrane|regulation of catalytic activity|cell projection organization|cell projection membrane|regulation of hormone levels|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|positive regulation of chemotaxis|developmental growth involved in morphogenesis|MAPK cascade|positive regulation of intracellular signal transduction|tubulin binding|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|cytosol|neuron projection development|response to carbohydrate|regulation of cell projection organization|positive regulation of Schwann cell chemotaxis|cell surface receptor signaling pathway|regulation of peptide hormone secretion|dendritic spine morphogenesis|axon|macromolecule modification|neuron spine|regulation of dendrite development|positive regulation of hydrolase activity|positive regulation of cell development|dendritic spine organization|chemical homeostasis|dendrite morphogenesis|regulation of protein transport|axonal growth cone|protein transport|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|microtubule binding|regulation of cell migration|receptor tyrosine kinase binding|positive regulation of transferase activity|protein modification process|regulation of establishment of protein localization|cell-matrix adhesion|amide transport|cellular chemical homeostasis|main axon|positive regulation of dendritic spine development|regulation of secretion|response to alkaloid|protein localization to membrane|stress-activated protein kinase signaling cascade|cell chemotaxis|positive regulation of neurogenesis|dendrite|hormone transport|protein secretion|positive regulation of protein metabolic process|response to growth factor|regulation of cell morphogenesis|cellular protein localization|ruffle membrane|insulin secretion involved in cellular response to glucose stimulus|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|response to ammonium ion|cellular protein metabolic process|regulation of phosphorus metabolic process|muscle hypertrophy|cell part morphogenesis|nervous system development|secretion|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|GTPase binding|cell differentiation|cell projection morphogenesis|positive regulation of dendrite development|positive regulation of cell migration|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|cytoskeleton|nucleus|response to cocaine|regulation of programmed cell death|neuron projection extension|regulation of nervous system development|apoptotic signaling pathway|neuron development|glial cell migration|neuron differentiation|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|axon guidance|positive regulation of stress-activated protein kinase signaling cascade|insulin secretion|regulation of neuron projection development|positive regulation of protein modification process|cellular glucose homeostasis|positive regulation of dendritic spine morphogenesis|positive regulation of apoptotic process|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|Rac guanyl-nucleotide exchange factor activity|regulation of glial cell migration|response to monosaccharide|regulation of protein secretion|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|peptide transport|neurotrophin signaling pathway|positive regulation of dendrite morphogenesis|ERK1 and ERK2 cascade|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|regulation of dendrite morphogenesis|small GTPase binding|positive regulation of MAPK cascade|positive regulation of gliogenesis|regulation of stress-activated MAPK cascade|regulation of apoptotic process|regulation of small GTPase mediated signal transduction|protein kinase binding|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|stress-activated MAPK cascade|hormone secretion|positive regulation of neuron projection development|regulation of dendritic spine morphogenesis|regulation of kinase activity|apoptotic process|carbohydrate homeostasis|positive regulation of kinase activity|positive regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|cardiac muscle hypertrophy|cellular response to glucose stimulus|glucose homeostasis|peptide hormone secretion|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|activation of GTPase activity|Ras GTPase binding|regulation of JNK cascade|axonogenesis|protein phosphorylation|generation of neurons|regulation of gliogenesis|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein tyrosine kinase binding|gliogenesis|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|positive regulation of Schwann cell migration|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of JNK cascade|Rho GTPase binding|positive regulation of JUN kinase activity|ephrin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|Rac protein signal transduction|response to glucose|regulation of Rho protein signal transduction|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|Rho protein signal transduction|Rac GTPase binding K05731 T-lymphoma invasion and metastasis-inducing protein 1[-] hsa04810|hsa04015|hsa05205|hsa04024|hsa04062 Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human) 21:31118416-31559977 71 69 144 487 574 669 0.402978005507571 0.35592187018484 0.736882973129407 2.47656401099493 2.67302709301386 3.55859219136445 0.498594282940606 2.90272776512441 -2.54147102830375 1.16913691952961e-17 7.19741463767115e-16 DOWN ENSG00000133195 SLC39A11 solute carrier family 39 member 11 [Source:HGNC Symbol;Acc:HGNC:14463] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0006810|GO:0043231|GO:0005737|GO:0022891|GO:0055085|GO:0016021|GO:0005794|GO:0006811|GO:0015075|GO:0005634|GO:0034220|GO:0098655|GO:0006812|GO:0008324|GO:0022890|GO:0030001|GO:0071577|GO:0046873|GO:0046915|GO:0006829|GO:0005385 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|transport|intracellular membrane-bounded organelle|cytoplasm|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|Golgi apparatus|ion transport|ion transmembrane transporter activity|nucleus|ion transmembrane transport|cation transmembrane transport|cation transport|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|zinc II ion transmembrane transport|metal ion transmembrane transporter activity|transition metal ion transmembrane transporter activity|zinc II ion transport|zinc ion transmembrane transporter activity - - - - 17:72645949-73092712 237 258 406 1108 1191 1265 1.62416357485249 1.60687114284053 2.50854695089404 6.80329512832079 6.6967089400903 8.12458582625685 1.91319388952902 7.20819663155598 -1.91365527811807 1.17566821691867e-17 7.22189278763169e-16 DOWN ENSG00000172493 AFF1 AF4/FMR2 family member 1 [Source:HGNC Symbol;Acc:HGNC:7135] GO:0032991|GO:0005623|GO:0001071|GO:0005488|GO:0003700|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0008023|GO:0043231|GO:0031981|GO:0005654|GO:0005634 macromolecular complex|cell|nucleic acid binding transcription factor activity|binding|transcription factor activity, sequence-specific DNA binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|protein complex|transcription elongation factor complex|intracellular membrane-bounded organelle|nuclear lumen|nucleoplasm|nucleus K15184 AF4/FMR2 family member 1[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 4:86935002-87141054 171 165 364 1128 1223 1646 0.620371447440858 0.54402683699376 1.19061494469279 3.66658966296296 3.64040913861807 5.59647231209878 0.785004409709136 4.30115703789327 -2.4539521425475 1.19331907547105e-17 7.3152664638835e-16 DOWN ENSG00000256542 RP13-895J2.3 - - - - - - - 12:132277349-132280900 0 0 0 28 48 30 0 0 0 0.583942005521331 0.91668784985894 0.654443707908243 0 0.718357854429505 -Inf 1.22243998235074e-17 7.47842689202847e-16 DOWN ENSG00000141002 TCF25 transcription factor 25 (basic helix-loop-helix) [Source:HGNC Symbol;Acc:HGNC:29181] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0007507|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0072358|GO:0010629|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0072359|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|heart development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cardiovascular system development|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|circulatory system development|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 16:89873586-89911384 280 257 302 1052 1062 1016 1.57743909515537 1.31585433728725 1.53396817971737 5.31016349195353 4.90893024185814 5.3643500568501 1.47575387072 5.19448126355392 -1.81552755867674 1.22916310488439e-17 7.50417900474818e-16 DOWN ENSG00000164574 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 [Source:HGNC Symbol;Acc:HGNC:19873] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0008376|GO:0006464|GO:0016266|GO:0004653|GO:0043687 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|acetylgalactosaminyltransferase activity|cellular protein modification process|O-glycan processing|polypeptide N-acetylgalactosaminyltransferase activity|post-translational protein modification K00710 polypeptide N-acetylgalactosaminyltransferase[2.4.1.41] hsa01100|hsa00512 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human) 5:154190730-154420984 692 672 1294 3837 4267 3643 2.61918125273652 2.31158049368347 4.41578807514729 13.012154549756 13.2510486821336 12.9225369261972 3.11551660718909 13.0619133860289 -2.06782293454471 1.27364613667352e-17 7.75988403352065e-16 DOWN ENSG00000112319 EYA4 EYA transcriptional coactivator and phosphatase 4 [Source:HGNC Symbol;Acc:HGNC:3522] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006281|GO:0006725|GO:1901360|GO:0048839|GO:0007275|GO:0048513|GO:0050877|GO:0034641|GO:0016788|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0007423|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0043583|GO:0051252|GO:0006325|GO:0036211|GO:0007600|GO:0006259|GO:0006796|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0042578|GO:0006974|GO:0050953|GO:0016311|GO:0050954|GO:0032774|GO:2001141|GO:0016791|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0006470|GO:0007605|GO:1903506|GO:0004721|GO:0007601|GO:0035335|GO:0004725 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|inner ear development|multicellular organism development|animal organ development|neurological system process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|sensory organ development|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|ear development|regulation of RNA metabolic process|chromatin organization|protein modification process|sensory perception|DNA metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|phosphoric ester hydrolase activity|cellular response to DNA damage stimulus|sensory perception of light stimulus|dephosphorylation|sensory perception of mechanical stimulus|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphatase activity|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|protein dephosphorylation|sensory perception of sound|regulation of nucleic acid-templated transcription|phosphoprotein phosphatase activity|visual perception|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity - - - - 6:133240598-133532120 55 59 39 346 362 285 0.19554240121237 0.190640392406663 0.125015613876908 1.10218162361381 1.05598218009158 0.949629825199202 0.170399469165314 1.03593120963486 -2.60393545859497 1.43290245536723e-17 8.71239712882554e-16 DOWN ENSG00000152404 CWF19L2 CWF19-like 2, cell cycle control (S. pombe) [Source:HGNC Symbol;Acc:HGNC:26508] GO:0008152|GO:0003824 metabolic process|catalytic activity - - - - 11:107326345-107457844 42 39 71 344 330 266 0.582081145321459 0.491229468209557 0.887175072342487 4.27161206826384 3.75247097791689 3.45497537024598 0.653495228624501 3.82635280547557 -2.54972129463833 1.48332804858066e-17 9.00066576470059e-16 DOWN ENSG00000109083 IFT20 intraflagellar transport 20 [Source:HGNC Symbol;Acc:HGNC:30989] GO:0032502|GO:0032991|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0009056|GO:0009628|GO:0044237|GO:0051641|GO:0006914|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0009605|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0005929|GO:0048646|GO:0031090|GO:0019222|GO:0007507|GO:0030992|GO:0010506|GO:0002046|GO:0051640|GO:0001822|GO:0009888|GO:0048468|GO:0009314|GO:1902115|GO:0006810|GO:0009991|GO:0007275|GO:0048513|GO:0050877|GO:0030990|GO:0031982|GO:0051128|GO:0033554|GO:0007632|GO:0022607|GO:0061061|GO:0043231|GO:0031514|GO:0005737|GO:0044292|GO:0097546|GO:0006928|GO:0043005|GO:0009966|GO:0045184|GO:0072372|GO:0036477|GO:0036064|GO:0010646|GO:0008104|GO:0007154|GO:0001750|GO:0010970|GO:0060491|GO:0007165|GO:0070062|GO:0051649|GO:0061351|GO:0097542|GO:0007611|GO:0016236|GO:0030030|GO:0048869|GO:0007017|GO:0031323|GO:0005794|GO:0006996|GO:0030111|GO:0000902|GO:0005813|GO:0031344|GO:0007166|GO:0072358|GO:0007612|GO:0001655|GO:0042692|GO:0005815|GO:0035051|GO:0048738|GO:0015031|GO:2000785|GO:0005801|GO:1902017|GO:0005814|GO:0044782|GO:0060537|GO:0046907|GO:0072001|GO:0016241|GO:0030031|GO:0030425|GO:0007018|GO:0022604|GO:0034613|GO:0070925|GO:0051642|GO:0042384|GO:0033043|GO:0032990|GO:0031503|GO:0007399|GO:0050890|GO:0000139|GO:0030154|GO:0048858|GO:0000045|GO:0072359|GO:0031667|GO:0005856|GO:0009416|GO:0031513|GO:0007033|GO:0008542|GO:0048666|GO:0030182|GO:0060271|GO:0042461|GO:0016055|GO:0033365|GO:0042073|GO:0060828|GO:0032391|GO:0008306|GO:0007224|GO:0044088|GO:0006886|GO:0015630|GO:0036372|GO:0051146|GO:0035845|GO:0014706|GO:0022008|GO:0055007|GO:0030705|GO:0034067|GO:0048699|GO:0060070|GO:0061512 developmental process|macromolecular complex|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|catabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|autophagy|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|response to external stimulus|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|heart development|intraciliary transport particle B|regulation of autophagy|opsin binding|organelle localization|kidney development|tissue development|cell development|response to radiation|regulation of organelle assembly|transport|response to extracellular stimulus|multicellular organism development|animal organ development|neurological system process|intraciliary transport particle|vesicle|regulation of cellular component organization|cellular response to stress|visual behavior|cellular component assembly|muscle structure development|intracellular membrane-bounded organelle|motile cilium|cytoplasm|dendrite terminus|ciliary base|movement of cell or subcellular component|neuron projection|regulation of signal transduction|establishment of protein localization|primary cilium|somatodendritic compartment|ciliary basal body|regulation of cell communication|protein localization|cell communication|photoreceptor outer segment|establishment of localization by movement along microtubule|regulation of cell projection assembly|signal transduction|extracellular exosome|establishment of localization in cell|neural precursor cell proliferation|ciliary tip|learning or memory|macroautophagy|cell projection organization|cellular developmental process|microtubule-based process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|regulation of Wnt signaling pathway|cell morphogenesis|centrosome|regulation of cell projection organization|cell surface receptor signaling pathway|cardiovascular system development|learning|urogenital system development|muscle cell differentiation|microtubule organizing center|cardiocyte differentiation|cardiac muscle tissue development|protein transport|regulation of autophagosome assembly|cis-Golgi network|regulation of cilium assembly|centriole|cilium organization|muscle tissue development|intracellular transport|renal system development|regulation of macroautophagy|cell projection assembly|dendrite|microtubule-based movement|regulation of cell morphogenesis|cellular protein localization|organelle assembly|centrosome localization|cilium assembly|regulation of organelle organization|cell part morphogenesis|protein complex localization|nervous system development|cognition|Golgi membrane|cell differentiation|cell projection morphogenesis|autophagosome assembly|circulatory system development|response to nutrient levels|cytoskeleton|response to light stimulus|nonmotile primary cilium|vacuole organization|visual learning|neuron development|neuron differentiation|cilium morphogenesis|photoreceptor cell development|Wnt signaling pathway|protein localization to organelle|intraciliary transport|regulation of canonical Wnt signaling pathway|photoreceptor connecting cilium|associative learning|smoothened signaling pathway|regulation of vacuole organization|intracellular protein transport|microtubule cytoskeleton|opsin transport|striated muscle cell differentiation|photoreceptor cell outer segment organization|striated muscle tissue development|neurogenesis|cardiac muscle cell differentiation|cytoskeleton-dependent intracellular transport|protein localization to Golgi apparatus|generation of neurons|canonical Wnt signaling pathway|protein localization to cilium - - - - 17:28328325-28335489 54 63 80 323 342 320 0.430401259949026 0.456352727395972 0.574885708510378 2.30663010149647 2.23651605583722 2.39032317266311 0.487213231951792 2.31115644333227 -2.2459896996207 1.49749621057555e-17 9.06280196131205e-16 DOWN ENSG00000177200 CHD9 chromodomain helicase DNA binding protein 9 [Source:HGNC Symbol;Acc:HGNC:25701] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0044255|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0016817|GO:0043231|GO:0005737|GO:0006139|GO:0006629|GO:0000166|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0035639|GO:0051252|GO:0006325|GO:0001883|GO:0016818|GO:0032549|GO:0031981|GO:0005654|GO:0010467|GO:0017076|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0016568|GO:0016462|GO:0006351|GO:0006355|GO:1903506|GO:0017111|GO:0004386 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|cellular lipid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|lipid metabolic process|nucleotide binding|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|nucleoplasm|gene expression|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|chromatin modification|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|helicase activity - - - - 16:53055033-53329150 160 305 387 1280 1401 1814 0.373552715007512 0.647160128020796 0.814623803992594 2.67756070544691 2.68372422440168 3.96915415868264 0.611778882340301 3.11014636284374 -2.3459002616139 1.49963963585722e-17 9.06280196131205e-16 DOWN ENSG00000123643 SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 [Source:HGNC Symbol;Acc:HGNC:18761] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005774|GO:0005737|GO:0022891|GO:0055085|GO:0005783|GO:0016021|GO:0005773|GO:1903825|GO:0006811|GO:0015075|GO:0034220|GO:0098655|GO:0006820|GO:0015711|GO:0098656|GO:0000323|GO:0015293|GO:0015992|GO:0008509|GO:0006812|GO:0046942|GO:0046943|GO:0006865|GO:0005765|GO:0008324|GO:0015824|GO:0032328|GO:0015804|GO:0015193|GO:0015171|GO:0005764|GO:1902600|GO:0003333|GO:0015807|GO:0015187|GO:0022890|GO:0008514|GO:0015672|GO:0035524|GO:0015816|GO:0015175|GO:0015180|GO:0015295|GO:0015808|GO:0015179|GO:0015077|GO:0005280|GO:0015078 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|substrate-specific transmembrane transporter activity|transmembrane transport|endoplasmic reticulum|integral component of membrane|vacuole|organic acid transmembrane transport|ion transport|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|lytic vacuole|symporter activity|proton transport|anion transmembrane transporter activity|cation transport|carboxylic acid transport|carboxylic acid transmembrane transporter activity|amino acid transport|lysosomal membrane|cation transmembrane transporter activity|proline transport|alanine transport|neutral amino acid transport|L-proline transmembrane transporter activity|amino acid transmembrane transporter activity|lysosome|hydrogen ion transmembrane transport|amino acid transmembrane transport|L-amino acid transport|glycine transmembrane transporter activity|inorganic cation transmembrane transporter activity|organic anion transmembrane transporter activity|monovalent inorganic cation transport|proline transmembrane transport|glycine transport|neutral amino acid transmembrane transporter activity|L-alanine transmembrane transporter activity|solute:proton symporter activity|L-alanine transport|L-amino acid transmembrane transporter activity|monovalent inorganic cation transmembrane transporter activity|hydrogen:amino acid symporter activity|hydrogen ion transmembrane transporter activity K14209 solute carrier family 36 (proton-coupled amino acid transporter)[-] hsa04974 Protein digestion and absorption - Homo sapiens (human) 5:151437046-151492381 37 46 56 263 320 225 0.283098022769654 0.319871919484824 0.386317378416681 1.80298747764144 2.00889259933369 1.61343392777149 0.32976244022372 1.80843800158221 -2.45524514813155 1.59813055048022e-17 9.6385029200074e-16 DOWN ENSG00000182158 CREB3L2 cAMP responsive element binding protein 3-like 2 [Source:HGNC Symbol;Acc:HGNC:23720] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0006725|GO:0009888|GO:0006810|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0000981|GO:0006139|GO:0007154|GO:0007165|GO:0005783|GO:0051649|GO:0048869|GO:0016021|GO:0044249|GO:0010033|GO:0031323|GO:0016192|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0051216|GO:0030968|GO:0051252|GO:0010628|GO:0046907|GO:0006986|GO:0031981|GO:0005654|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0001228|GO:0035967|GO:0016070|GO:0034976|GO:0010557|GO:0005634|GO:0034620|GO:0000975|GO:0045893|GO:0002062|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0048193|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0006888|GO:0035497|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|transport|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|endoplasmic reticulum|establishment of localization in cell|cellular developmental process|integral component of membrane|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|vesicle-mediated transport|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|endoplasmic reticulum unfolded protein response|regulation of RNA metabolic process|positive regulation of gene expression|intracellular transport|response to unfolded protein|nuclear lumen|nucleoplasm|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|cellular response to topologically incorrect protein|RNA metabolic process|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to unfolded protein|regulatory region DNA binding|positive regulation of transcription, DNA-templated|chondrocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|Golgi vesicle transport|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|ER to Golgi vesicle-mediated transport|cAMP response element binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09048 cyclic AMP-responsive element-binding protein 3[-] hsa04151|hsa05203|hsa04024|hsa05016|hsa05034|hsa04022|hsa04261|hsa05161|hsa04728|hsa04152|hsa04725|hsa04668|hsa04931|hsa04922|hsa04916|hsa04915|hsa04211|hsa05215|hsa04911|hsa04925|hsa04918|hsa05031|hsa05030|hsa04962 PI3K-Akt signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human)|Vasopressin-regulated water reabsorption - Homo sapiens (human) 7:137874979-138002067 157 149 389 1306 1410 1759 0.649264328557653 0.560002246971016 1.45039626526519 4.83908636674634 4.78420421594771 6.81738050882723 0.88655428026462 5.48022369717376 -2.62795391419877 1.64612137312335e-17 9.90792489379527e-16 DOWN ENSG00000168228 ZCCHC4 zinc finger, CCHC domain containing 4 [Source:HGNC Symbol;Acc:HGNC:22917] GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0043167|GO:0016740|GO:0003676|GO:0043169|GO:0008168|GO:0046872|GO:0046914|GO:0008270 metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|ion binding|transferase activity|nucleic acid binding|cation binding|methyltransferase activity|metal ion binding|transition metal ion binding|zinc ion binding - - - - 4:25312785-25370383 26 22 45 207 212 209 0.264548172842519 0.203440829364144 0.412818213078467 1.88714322802596 1.76986697427068 1.99302124607352 0.293602405095043 1.88334381612339 -2.68136070551606 1.90876474974659e-17 1.14656464464657e-15 DOWN ENSG00000155008 APOOL apolipoprotein O-like [Source:HGNC Symbol;Acc:HGNC:24009] GO:0032991|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0019866|GO:0043231|GO:0005737|GO:0031966|GO:0016021|GO:0031301|GO:0005740|GO:0061617|GO:0005743|GO:0031304|GO:0005739|GO:0032592|GO:0031305 macromolecular complex|cell|membrane|binding|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|organelle membrane|organelle inner membrane|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|integral component of membrane|integral component of organelle membrane|mitochondrial envelope|MICOS complex|mitochondrial inner membrane|intrinsic component of mitochondrial inner membrane|mitochondrion|integral component of mitochondrial membrane|integral component of mitochondrial inner membrane - - - - X:85003826-85093316 16 18 27 138 149 140 0.15783060495322 0.161368210489925 0.240130250973978 1.21966769888202 1.20592680849767 1.29426901933306 0.186443022139041 1.23995450890425 -2.73348048381444 1.98130943809919e-17 1.18775124427737e-15 DOWN ENSG00000187079 TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) [Source:HGNC Symbol;Acc:HGNC:11714] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0035556|GO:0010467|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0003690|GO:0035329|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006352|GO:0006357|GO:1903506|GO:0044212|GO:0006367|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|intracellular signal transduction|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|hippo signaling|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription initiation from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09448 transcriptional enhancer factor[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) 11:12674591-12944483 226 157 475 2304 1965 1711 0.767475472718347 0.484548096546893 1.45433543410326 7.01029991857032 5.4750366500579 5.44547070210546 0.9021196677895 5.97693575691123 -2.72801530867202 2.02494963387923e-17 1.21147988717095e-15 DOWN ENSG00000167291 TBC1D16 TBC1 domain family member 16 [Source:HGNC Symbol;Acc:HGNC:28356] GO:0008152|GO:0005488|GO:0009893|GO:0030234|GO:0005515|GO:0019222|GO:0008047|GO:0043085|GO:0050790|GO:0005096|GO:0051345|GO:0030695|GO:0043087|GO:0043547 metabolic process|binding|positive regulation of metabolic process|enzyme regulator activity|protein binding|regulation of metabolic process|enzyme activator activity|positive regulation of catalytic activity|regulation of catalytic activity|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|regulation of GTPase activity|positive regulation of GTPase activity - - - - 17:79932343-80035848 226 235 426 1119 1334 1349 0.749942022644986 0.708708843328761 1.27450935491433 3.32695827903065 3.63198038288172 4.195275258144 0.911053406962692 3.71807130668546 -2.02894690511092 2.22317037479625e-17 1.32741056738334e-15 DOWN ENSG00000143367 TUFT1 tuftelin 1 [Source:HGNC Symbol;Acc:HGNC:12422] GO:0032502|GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0005201|GO:0050794|GO:0043229|GO:0009653|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0009888|GO:0007275|GO:0048513|GO:0043231|GO:0005737|GO:0009887|GO:0007154|GO:0007165|GO:0001503|GO:0031214|GO:0031981|GO:1990234|GO:0005654|GO:0035556|GO:0042476|GO:0005634|GO:0030282|GO:0030345|GO:0016591 developmental process|macromolecular complex|structural molecule activity|signaling|cell|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|extracellular matrix structural constituent|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|membrane-bounded organelle|intracellular|protein binding|protein complex|anatomical structure development|tissue development|multicellular organism development|animal organ development|intracellular membrane-bounded organelle|cytoplasm|organ morphogenesis|cell communication|signal transduction|ossification|biomineral tissue development|nuclear lumen|transferase complex|nucleoplasm|intracellular signal transduction|odontogenesis|nucleus|bone mineralization|structural constituent of tooth enamel|DNA-directed RNA polymerase II, holoenzyme - - - - 1:151540305-151583583 144 133 246 807 778 808 1.66249337215245 1.39550213826899 2.56063331174622 8.3477474981388 7.36962957544207 8.74254632878805 1.87287627405589 8.15330780078964 -2.12212988474209 2.38404653078811e-17 1.42062525209877e-15 DOWN ENSG00000075223 SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C [Source:HGNC Symbol;Acc:HGNC:10725] GO:0040011|GO:0032502|GO:0040007|GO:0045499|GO:0002376|GO:0007610|GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0040013|GO:0048523|GO:0048521|GO:0050794|GO:0040012|GO:0016049|GO:0006955|GO:0050795|GO:0048870|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0040008|GO:0009605|GO:0005615|GO:0050793|GO:0048589|GO:0005515|GO:0048856|GO:0048646|GO:0007507|GO:0051272|GO:0001756|GO:0006935|GO:0009791|GO:0045595|GO:0009888|GO:0048468|GO:0035295|GO:0001568|GO:0007275|GO:0045596|GO:0048513|GO:0032535|GO:0005102|GO:0031982|GO:0051128|GO:2000147|GO:0060174|GO:0030308|GO:0007389|GO:0001763|GO:0050920|GO:0006928|GO:0009887|GO:0021915|GO:0048729|GO:0048771|GO:0042493|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0003151|GO:0070062|GO:0048638|GO:0050922|GO:0051271|GO:0048640|GO:0030030|GO:0048869|GO:2000145|GO:0001558|GO:0048732|GO:0003205|GO:0060560|GO:0050768|GO:0000902|GO:0031175|GO:0031344|GO:0007166|GO:0002009|GO:0003208|GO:0001944|GO:0072358|GO:0003007|GO:0010721|GO:0061138|GO:0022612|GO:0038191|GO:0000904|GO:0050919|GO:0009790|GO:0030334|GO:0001667|GO:0030517|GO:0060537|GO:0031345|GO:0003002|GO:0007431|GO:0060485|GO:0003231|GO:0008361|GO:0022604|GO:0035272|GO:0001974|GO:0060429|GO:0035108|GO:0048864|GO:0030516|GO:0032990|GO:0030215|GO:0060841|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0060173|GO:0030335|GO:0072359|GO:1902667|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0001755|GO:0048863|GO:0010975|GO:0009792|GO:0010769|GO:0048841|GO:0014031|GO:0061564|GO:0003350|GO:0061053|GO:0060445|GO:0009952|GO:0003215|GO:0048762|GO:0007435|GO:0045665|GO:0071526|GO:0014706|GO:0022008|GO:0048667|GO:0050767|GO:0048843|GO:0048812|GO:0010977|GO:0035282|GO:0050771|GO:0048675|GO:0014033|GO:0014032|GO:0007409|GO:0048699|GO:0060666|GO:0043009|GO:0048846|GO:0050770|GO:0045664 locomotion|developmental process|growth|chemorepellent activity|immune system process|behavior|signaling|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|negative regulation of cellular process|negative regulation of behavior|regulation of cellular process|regulation of locomotion|cell growth|immune response|regulation of behavior|cell motility|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|regulation of growth|response to external stimulus|extracellular space|regulation of developmental process|developmental growth|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|heart development|positive regulation of cellular component movement|somitogenesis|chemotaxis|post-embryonic development|regulation of cell differentiation|tissue development|cell development|tube development|blood vessel development|multicellular organism development|negative regulation of cell differentiation|animal organ development|regulation of cellular component size|receptor binding|vesicle|regulation of cellular component organization|positive regulation of cell motility|limb bud formation|negative regulation of cell growth|pattern specification process|morphogenesis of a branching structure|regulation of chemotaxis|movement of cell or subcellular component|organ morphogenesis|neural tube development|tissue morphogenesis|tissue remodeling|response to drug|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|outflow tract morphogenesis|extracellular exosome|regulation of developmental growth|negative regulation of chemotaxis|negative regulation of cellular component movement|negative regulation of developmental growth|cell projection organization|cellular developmental process|regulation of cell motility|regulation of cell growth|gland development|cardiac chamber development|developmental growth involved in morphogenesis|negative regulation of neurogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|cell surface receptor signaling pathway|morphogenesis of an epithelium|cardiac ventricle morphogenesis|vasculature development|cardiovascular system development|heart morphogenesis|negative regulation of cell development|morphogenesis of a branching epithelium|gland morphogenesis|neuropilin binding|cell morphogenesis involved in differentiation|negative chemotaxis|embryo development|regulation of cell migration|ameboidal-type cell migration|negative regulation of axon extension|muscle tissue development|negative regulation of cell projection organization|regionalization|salivary gland development|mesenchyme development|cardiac ventricle development|regulation of cell size|regulation of cell morphogenesis|exocrine system development|blood vessel remodeling|epithelium development|limb morphogenesis|stem cell development|regulation of axon extension|cell part morphogenesis|semaphorin receptor binding|venous blood vessel development|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|limb development|positive regulation of cell migration|circulatory system development|regulation of axon guidance|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|neural crest cell migration|stem cell differentiation|regulation of neuron projection development|embryo development ending in birth or egg hatching|regulation of cell morphogenesis involved in differentiation|regulation of axon extension involved in axon guidance|mesenchymal cell development|axon development|pulmonary myocardium development|somite development|branching involved in salivary gland morphogenesis|anterior/posterior pattern specification|cardiac right ventricle morphogenesis|mesenchymal cell differentiation|salivary gland morphogenesis|negative regulation of neuron differentiation|semaphorin-plexin signaling pathway|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|negative regulation of axon extension involved in axon guidance|neuron projection morphogenesis|negative regulation of neuron projection development|segmentation|negative regulation of axonogenesis|axon extension|neural crest cell differentiation|neural crest cell development|axonogenesis|generation of neurons|dichotomous subdivision of terminal units involved in salivary gland branching|chordate embryonic development|axon extension involved in axon guidance|regulation of axonogenesis|regulation of neuron differentiation K06840 semaphorin 3[-] hsa04360 Axon guidance - Homo sapiens (human) 7:80742538-80922359 205 274 460 1231 1522 1513 1.86581010606501 2.26643344951943 3.77472589894456 10.0384931360285 11.3656851233253 12.9056813246023 2.635656484843 11.4366198613187 -2.11742646506661 2.47920420651438e-17 1.47438570480638e-15 DOWN ENSG00000104375 STK3 serine/threonine kinase 3 [Source:HGNC Symbol;Acc:HGNC:11406] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0023051|GO:0045926|GO:0009653|GO:0043227|GO:0040008|GO:0023057|GO:0009893|GO:0009058|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0051726|GO:0042127|GO:0007049|GO:0001890|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0060706|GO:0060800|GO:0034641|GO:0043168|GO:0046620|GO:0008047|GO:0003157|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0046621|GO:0010942|GO:0035265|GO:0051098|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0005737|GO:0021915|GO:0009966|GO:0048729|GO:0046983|GO:0048598|GO:0048568|GO:0010646|GO:0006139|GO:0001892|GO:0043085|GO:0007154|GO:0035148|GO:0007165|GO:0009968|GO:0031647|GO:0048638|GO:0008219|GO:0008285|GO:0048640|GO:0050790|GO:0000166|GO:0019207|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031323|GO:0051090|GO:0000165|GO:1902533|GO:2001235|GO:0032268|GO:0030111|GO:0005829|GO:0010468|GO:0034645|GO:0030178|GO:0046872|GO:0007166|GO:0002009|GO:0035639|GO:0043412|GO:0061458|GO:0030097|GO:0072358|GO:0007417|GO:0050821|GO:0019887|GO:0051252|GO:0001883|GO:0009790|GO:0010628|GO:0072175|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0051091|GO:0016331|GO:0031098|GO:0045600|GO:0007346|GO:0051099|GO:0035162|GO:0051247|GO:0016301|GO:0001841|GO:0032270|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0019209|GO:0007399|GO:0060562|GO:0017076|GO:0045598|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0043068|GO:1902531|GO:0016070|GO:0072359|GO:0016773|GO:0010557|GO:0005634|GO:0043067|GO:0097190|GO:0045995|GO:0043393|GO:0051896|GO:0003158|GO:0016055|GO:0043491|GO:0070304|GO:0045893|GO:0045444|GO:0009792|GO:0031401|GO:0090090|GO:0043065|GO:0043408|GO:0060828|GO:0000287|GO:0032774|GO:0005524|GO:2001141|GO:0001838|GO:2001236|GO:0030554|GO:0016310|GO:0051897|GO:2001238|GO:0035329|GO:0032092|GO:0030295|GO:0060215|GO:0043410|GO:0032872|GO:0042981|GO:0004672|GO:0006464|GO:0097191|GO:0051403|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0033674|GO:0045859|GO:0045860|GO:0046328|GO:1902043|GO:0006468|GO:1903506|GO:0043539|GO:0060070|GO:0042325|GO:0007254|GO:0001932|GO:0004674|GO:0043009|GO:0032874|GO:0001934|GO:0042327|GO:0008625|GO:1902041|GO:0046330|GO:0097284|GO:0071902|GO:0071900|GO:0001701 developmental process|growth|macromolecular complex|reproduction|immune system process|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|negative regulation of growth|anatomical structure morphogenesis|membrane-bounded organelle|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|regulation of cell cycle|regulation of cell proliferation|cell cycle|placenta development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|cellular nitrogen compound metabolic process|anion binding|regulation of organ growth|enzyme activator activity|endocardium development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|negative regulation of organ growth|positive regulation of cell death|organ growth|regulation of binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|cytoplasm|neural tube development|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|embryonic organ development|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|positive regulation of catalytic activity|cell communication|tube formation|signal transduction|negative regulation of signal transduction|regulation of protein stability|regulation of developmental growth|cell death|negative regulation of cell proliferation|negative regulation of developmental growth|regulation of catalytic activity|nucleotide binding|kinase regulator activity|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|MAPK cascade|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|metal ion binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|macromolecule modification|reproductive system development|hemopoiesis|cardiovascular system development|central nervous system development|protein stabilization|protein kinase regulator activity|regulation of RNA metabolic process|purine nucleoside binding|embryo development|positive regulation of gene expression|epithelial tube formation|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|positive regulation of sequence-specific DNA binding transcription factor activity|morphogenesis of embryonic epithelium|stress-activated protein kinase signaling cascade|positive regulation of fat cell differentiation|regulation of mitotic cell cycle|positive regulation of binding|embryonic hemopoiesis|positive regulation of protein metabolic process|kinase activity|neural tube formation|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|kinase activator activity|nervous system development|epithelial tube morphogenesis|purine nucleotide binding|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|apoptotic signaling pathway|regulation of embryonic development|regulation of protein binding|regulation of protein kinase B signaling|endothelium development|Wnt signaling pathway|protein kinase B signaling|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|fat cell differentiation|embryo development ending in birth or egg hatching|positive regulation of protein modification process|negative regulation of canonical Wnt signaling pathway|positive regulation of apoptotic process|regulation of MAPK cascade|regulation of canonical Wnt signaling pathway|magnesium ion binding|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|embryonic epithelial tube formation|regulation of extrinsic apoptotic signaling pathway|adenyl nucleotide binding|phosphorylation|positive regulation of protein kinase B signaling|positive regulation of extrinsic apoptotic signaling pathway|hippo signaling|positive regulation of protein binding|protein kinase activator activity|primitive hemopoiesis|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|protein kinase activity|cellular protein modification process|extrinsic apoptotic signaling pathway|stress-activated MAPK cascade|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of JNK cascade|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|protein phosphorylation|regulation of nucleic acid-templated transcription|protein serine/threonine kinase activator activity|canonical Wnt signaling pathway|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity|chordate embryonic development|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|positive regulation of phosphorylation|extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway via death domain receptors|positive regulation of JNK cascade|hepatocyte apoptotic process|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|in utero embryonic development K04412 serine/threonine kinase 3[-] hsa04010|hsa04390 MAPK signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human) 8:98401403-98942827 120 156 324 1027 1168 1182 0.45192062607002 0.53393063537959 1.10012004792127 3.46536354942787 3.60903778196568 4.17183747971671 0.695323769790293 3.74874627037009 -2.43065136743548 2.48789529773861e-17 1.47661284729003e-15 DOWN ENSG00000151422 FER fer (fps/fes related) tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3655] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0042995|GO:0002683|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044089|GO:0071704|GO:0050900|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0000785|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0031252|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0060341|GO:0008284|GO:0051272|GO:0042127|GO:0007049|GO:0036119|GO:0016337|GO:0009898|GO:0006935|GO:0045087|GO:0006725|GO:0051640|GO:0045123|GO:0048468|GO:0006810|GO:0051130|GO:1901360|GO:0005938|GO:0034446|GO:0060627|GO:0032535|GO:0005102|GO:0034641|GO:0043168|GO:0032940|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0022607|GO:0098609|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0032970|GO:0006928|GO:0031234|GO:0051656|GO:0001775|GO:0098562|GO:0031589|GO:0009966|GO:0030027|GO:0002263|GO:0019897|GO:0006979|GO:0010646|GO:0006139|GO:0009617|GO:0050776|GO:0000790|GO:0050904|GO:0050865|GO:0007154|GO:0051270|GO:0060491|GO:0016477|GO:0007165|GO:0002366|GO:0035426|GO:0051649|GO:0050777|GO:0009725|GO:0002695|GO:0000166|GO:0030030|GO:0043299|GO:0048869|GO:0030029|GO:2000145|GO:0044249|GO:0007017|GO:0019538|GO:0031334|GO:0043254|GO:0010033|GO:0031323|GO:0002443|GO:0006996|GO:0051090|GO:0016192|GO:0032268|GO:0000902|GO:0005829|GO:0031344|GO:0010468|GO:0034645|GO:0044331|GO:0007166|GO:0032956|GO:0070851|GO:0033993|GO:0035639|GO:0043412|GO:0007010|GO:0034097|GO:0033004|GO:0002237|GO:0051252|GO:0043303|GO:0032386|GO:0001883|GO:0033003|GO:1901652|GO:0000904|GO:0071417|GO:0010628|GO:0030334|GO:0001667|GO:0006887|GO:0036211|GO:0000278|GO:0046907|GO:0032549|GO:0033007|GO:0045576|GO:0051091|GO:0019902|GO:0017157|GO:0051046|GO:0031981|GO:1901184|GO:0043434|GO:0030031|GO:0034599|GO:0070848|GO:0005694|GO:0002764|GO:0000228|GO:0006461|GO:0016301|GO:0030036|GO:0000302|GO:0097581|GO:0006796|GO:0035556|GO:0032273|GO:0033043|GO:0044267|GO:0051174|GO:0010591|GO:0010467|GO:0046903|GO:0071310|GO:0017076|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0030832|GO:0032418|GO:0030335|GO:0016070|GO:0000226|GO:0016773|GO:0032870|GO:0005856|GO:0010557|GO:0032496|GO:0005634|GO:0010638|GO:0015629|GO:0045893|GO:0019221|GO:0030032|GO:0045055|GO:0043304|GO:0031532|GO:0034622|GO:0030838|GO:1901653|GO:0005154|GO:0042058|GO:0032774|GO:0005524|GO:2001141|GO:0043623|GO:0030554|GO:0016310|GO:0051092|GO:0002768|GO:0008064|GO:0019903|GO:0051493|GO:0007167|GO:0015630|GO:0010762|GO:0071375|GO:0002448|GO:1903305|GO:0071345|GO:0004672|GO:0032868|GO:0034614|GO:0006464|GO:0007015|GO:0051495|GO:0010761|GO:0030833|GO:0006351|GO:0006355|GO:0070741|GO:0051258|GO:0036006|GO:0007259|GO:0038109|GO:0006468|GO:1903506|GO:0008157|GO:0042325|GO:0004713|GO:0071354|GO:0001932|GO:0070102|GO:0032869|GO:0018193|GO:0038093|GO:0007169|GO:0008154|GO:0004715|GO:0048008|GO:0046777|GO:0038095|GO:0007260|GO:0030041|GO:0008286|GO:0038127|GO:0018108|GO:0038083|GO:0007173|GO:0042503|GO:0038028 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|cell projection|negative regulation of immune system process|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|leukocyte migration|ion binding|immune response|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|chromatin|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|cell leading edge|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|cell cycle|response to platelet-derived growth factor|single organismal cell-cell adhesion|cytoplasmic side of plasma membrane|chemotaxis|innate immune response|cellular aromatic compound metabolic process|organelle localization|cellular extravasation|cell development|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|cell cortex|substrate adhesion-dependent cell spreading|regulation of vesicle-mediated transport|regulation of cellular component size|receptor binding|cellular nitrogen compound metabolic process|anion binding|secretion by cell|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|cellular component assembly|cell-cell adhesion|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|movement of cell or subcellular component|extrinsic component of cytoplasmic side of plasma membrane|establishment of organelle localization|cell activation|cytoplasmic side of membrane|cell-substrate adhesion|regulation of signal transduction|lamellipodium|cell activation involved in immune response|extrinsic component of plasma membrane|response to oxidative stress|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|nuclear chromatin|diapedesis|regulation of cell activation|cell communication|regulation of cellular component movement|regulation of cell projection assembly|cell migration|signal transduction|leukocyte activation involved in immune response|extracellular matrix-cell signaling|establishment of localization in cell|negative regulation of immune response|response to hormone|negative regulation of leukocyte activation|nucleotide binding|cell projection organization|leukocyte degranulation|cellular developmental process|actin filament-based process|regulation of cell motility|cellular biosynthetic process|microtubule-based process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|regulation of cellular metabolic process|leukocyte mediated immunity|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|vesicle-mediated transport|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|cell-cell adhesion mediated by cadherin|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|growth factor receptor binding|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|response to cytokine|negative regulation of mast cell activation|response to molecule of bacterial origin|regulation of RNA metabolic process|mast cell degranulation|regulation of intracellular transport|purine nucleoside binding|regulation of mast cell activation|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of gene expression|regulation of cell migration|ameboidal-type cell migration|exocytosis|protein modification process|mitotic cell cycle|intracellular transport|ribonucleoside binding|negative regulation of mast cell activation involved in immune response|mast cell activation|positive regulation of sequence-specific DNA binding transcription factor activity|phosphatase binding|regulation of exocytosis|regulation of secretion|nuclear lumen|regulation of ERBB signaling pathway|response to peptide hormone|cell projection assembly|cellular response to oxidative stress|response to growth factor|chromosome|immune response-regulating signaling pathway|nuclear chromosome|protein complex assembly|kinase activity|actin cytoskeleton organization|response to reactive oxygen species|lamellipodium organization|phosphate-containing compound metabolic process|intracellular signal transduction|positive regulation of protein polymerization|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of lamellipodium assembly|gene expression|secretion|cellular response to organic substance|purine nucleotide binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|regulation of actin filament length|lysosome localization|positive regulation of cell migration|RNA metabolic process|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|positive regulation of organelle organization|actin cytoskeleton|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|lamellipodium assembly|regulated exocytosis|regulation of mast cell degranulation|actin cytoskeleton reorganization|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|cellular response to peptide|epidermal growth factor receptor binding|regulation of epidermal growth factor receptor signaling pathway|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|cellular protein complex assembly|adenyl nucleotide binding|phosphorylation|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|regulation of actin polymerization or depolymerization|protein phosphatase binding|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|regulation of fibroblast migration|cellular response to peptide hormone stimulus|mast cell mediated immunity|regulation of regulated secretory pathway|cellular response to cytokine stimulus|protein kinase activity|response to insulin|cellular response to reactive oxygen species|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|fibroblast migration|regulation of actin filament polymerization|transcription, DNA-templated|regulation of transcription, DNA-templated|response to interleukin-6|protein polymerization|cellular response to macrophage colony-stimulating factor stimulus|JAK-STAT cascade|Kit signaling pathway|protein phosphorylation|regulation of nucleic acid-templated transcription|protein phosphatase 1 binding|regulation of phosphorylation|protein tyrosine kinase activity|cellular response to interleukin-6|regulation of protein phosphorylation|interleukin-6-mediated signaling pathway|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|non-membrane spanning protein tyrosine kinase activity|platelet-derived growth factor receptor signaling pathway|protein autophosphorylation|Fc-epsilon receptor signaling pathway|tyrosine phosphorylation of STAT protein|actin filament polymerization|insulin receptor signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation|epidermal growth factor receptor signaling pathway|tyrosine phosphorylation of Stat3 protein|insulin receptor signaling pathway via phosphatidylinositol 3-kinase K08889 tyrosine-protein kinase Fer[2.7.10.2] hsa04520 Adherens junction - Homo sapiens (human) 5:108747822-109196841 89 47 98 445 501 534 0.388017582536624 0.186227033736464 0.385215137070598 1.73827733103031 1.79211850899174 2.18188170027592 0.319819917781229 1.90409251343266 -2.57377188097985 2.49726273283104e-17 1.47923177829242e-15 DOWN ENSG00000141564 RPTOR regulatory associated protein of MTOR, complex 1 [Source:HGNC Symbol;Acc:HGNC:30287] GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0097159|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0071704|GO:0009628|GO:0044237|GO:0006914|GO:0023051|GO:0044297|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:0043025|GO:0022402|GO:1901360|GO:0009991|GO:0003676|GO:0032535|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0045786|GO:0043231|GO:0019899|GO:0010243|GO:0005774|GO:0005737|GO:0031931|GO:0031668|GO:0009408|GO:0071889|GO:0032403|GO:0043005|GO:0009966|GO:0050673|GO:0036477|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0008134|GO:0009725|GO:0016236|GO:0050790|GO:0009967|GO:0044249|GO:0009266|GO:0019538|GO:0010033|GO:0031323|GO:1900034|GO:0050679|GO:1902533|GO:0032268|GO:0005829|GO:0003677|GO:0001025|GO:0010468|GO:0034645|GO:0007166|GO:0043412|GO:0051252|GO:1901652|GO:0007050|GO:0005773|GO:0071417|GO:0010628|GO:0043200|GO:0001935|GO:0051347|GO:0036211|GO:0031981|GO:0043434|GO:0030425|GO:0008361|GO:0034605|GO:0051247|GO:0005654|GO:0050678|GO:0019900|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0031669|GO:1902531|GO:0016070|GO:0031667|GO:0032870|GO:0010557|GO:0005634|GO:0032006|GO:0001156|GO:0000975|GO:0045893|GO:0031401|GO:0031929|GO:1901653|GO:0000323|GO:0032774|GO:0043565|GO:0032008|GO:2001141|GO:0016310|GO:0003690|GO:0001936|GO:0007167|GO:0071375|GO:0001938|GO:0032868|GO:0019901|GO:0006464|GO:0043549|GO:0071230|GO:0006351|GO:0005765|GO:0006355|GO:0033674|GO:0006366|GO:0045859|GO:0045860|GO:0006352|GO:0006383|GO:0005764|GO:0045945|GO:0006468|GO:1903506|GO:0044212|GO:0042325|GO:0006359|GO:0001932|GO:0032869|GO:0001934|GO:0042327|GO:0007169|GO:0006367|GO:0001016|GO:0000182|GO:0071902|GO:0071900|GO:0008286|GO:0001031|GO:0001032|GO:0001030 growth|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|autophagy|regulation of signaling|cell body|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|organelle membrane|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|neuronal cell body|cell cycle process|organic cyclic compound metabolic process|response to extracellular stimulus|nucleic acid binding|regulation of cellular component size|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|vacuolar membrane|cytoplasm|TORC1 complex|cellular response to extracellular stimulus|response to heat|14-3-3 protein binding|protein complex binding|neuron projection|regulation of signal transduction|epithelial cell proliferation|somatodendritic compartment|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|transcription factor binding|response to hormone|macroautophagy|regulation of catalytic activity|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of cellular response to heat|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|DNA binding|RNA polymerase III transcription factor binding|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|macromolecule modification|regulation of RNA metabolic process|response to peptide|cell cycle arrest|vacuole|cellular response to organonitrogen compound|positive regulation of gene expression|response to amino acid|endothelial cell proliferation|positive regulation of transferase activity|protein modification process|nuclear lumen|response to peptide hormone|dendrite|regulation of cell size|cellular response to heat|positive regulation of protein metabolic process|nucleoplasm|regulation of epithelial cell proliferation|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cellular response to nutrient levels|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|regulation of TOR signaling|TFIIIC-class transcription factor binding|regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|TOR signaling|cellular response to peptide|lytic vacuole|RNA biosynthetic process|sequence-specific DNA binding|positive regulation of TOR signaling|regulation of RNA biosynthetic process|phosphorylation|double-stranded DNA binding|regulation of endothelial cell proliferation|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of endothelial cell proliferation|response to insulin|protein kinase binding|cellular protein modification process|regulation of kinase activity|cellular response to amino acid stimulus|transcription, DNA-templated|lysosomal membrane|regulation of transcription, DNA-templated|positive regulation of kinase activity|transcription from RNA polymerase II promoter|regulation of protein kinase activity|positive regulation of protein kinase activity|DNA-templated transcription, initiation|transcription from RNA polymerase III promoter|lysosome|positive regulation of transcription from RNA polymerase III promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of phosphorylation|regulation of transcription from RNA polymerase III promoter|regulation of protein phosphorylation|cellular response to insulin stimulus|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|transcription initiation from RNA polymerase II promoter|RNA polymerase III regulatory region DNA binding|rDNA binding|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|insulin receptor signaling pathway|RNA polymerase III type 2 promoter DNA binding|RNA polymerase III type 3 promoter DNA binding|RNA polymerase III type 1 promoter DNA binding K07204 regulatory associated protein of mTOR[-] hsa04151|hsa05206|hsa04910|hsa04152|hsa04211|hsa04213|hsa04150 PI3K-Akt signaling pathway - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human) 17:80544819-80966371 215 232 289 840 996 887 1.00385556262831 0.984465615996312 1.21659118246846 3.51406738480554 3.81558023863516 3.88137692467512 1.06830412036436 3.73700818270527 -1.80656131679994 2.60092690102785e-17 1.53758557828288e-15 DOWN ENSG00000184220 CMSS1 cms1 ribosomal small subunit homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:28666] GO:0005488|GO:0097159|GO:0003676|GO:0003723|GO:0044822 binding|organic cyclic compound binding|nucleic acid binding|RNA binding|poly(A) RNA binding - - - - 3:99817834-100178603 82 98 105 704 825 368 1.08561055690532 1.17914198086259 1.25332745438341 8.3508601003808 8.96153313810042 4.56600908090353 1.17269333071711 7.29280077312825 -2.6366471969984 2.63074907312167e-17 1.55214195314178e-15 DOWN ENSG00000010803 SCMH1 sex comb on midleg homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:19003] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0007389|GO:0009890|GO:0016458|GO:0006139|GO:0007276|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0048232|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0036211|GO:0003002|GO:0031981|GO:0005654|GO:0005694|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0007283|GO:0045892|GO:0032774|GO:2001141|GO:0010369|GO:1902679|GO:0009952|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:1903507|GO:1903506|GO:0018193|GO:0043687|GO:0006338|GO:0032446|GO:0018205|GO:0016925 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|pattern specification process|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|gamete generation|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gamete generation|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|protein modification process|regionalization|nuclear lumen|nucleoplasm|chromosome|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|spermatogenesis|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|chromocenter|negative regulation of RNA biosynthetic process|anterior/posterior pattern specification|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|post-translational protein modification|chromatin remodeling|protein modification by small protein conjugation|peptidyl-lysine modification|protein sumoylation - - - - 1:41027200-41242154 87 74 140 475 537 544 0.818366775367074 0.632614408756801 1.18733072267004 4.00331265371806 4.14447726859638 4.7957391698809 0.879437302264638 4.31450969739845 -2.29454398788045 2.6556177016273e-17 1.56372408016531e-15 DOWN ENSG00000111412 C12orf49 chromosome 12 open reading frame 49 [Source:HGNC Symbol;Acc:HGNC:26128] GO:0005576|GO:0005488|GO:0005515 extracellular region|binding|protein binding - - - - 12:116710185-116738070 152 243 284 998 880 1038 0.984257749515953 1.43004804374513 1.65804645995885 5.79018445630021 4.67535813648704 6.299274740239 1.35745075107331 5.58827244434208 -2.04150250064038 2.91461734353407e-17 1.71285405854067e-15 DOWN ENSG00000152377 SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 [Source:HGNC Symbol;Acc:HGNC:11251] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0045202|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0031594|GO:0050794|GO:0060076|GO:0043229|GO:0005578|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0016043|GO:0007155|GO:0040008|GO:0005615|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0004857|GO:0045595|GO:0048468|GO:0007275|GO:0045596|GO:0030155|GO:0051128|GO:0043169|GO:0005737|GO:0006928|GO:0043005|GO:0031589|GO:0014069|GO:0007162|GO:0007154|GO:0044092|GO:0016477|GO:0007165|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0019538|GO:0001558|GO:0031324|GO:0031323|GO:0050768|GO:0032268|GO:0031175|GO:0031344|GO:0016528|GO:0046872|GO:0030424|GO:0007417|GO:0030414|GO:0010721|GO:0010812|GO:0032269|GO:0001764|GO:0044304|GO:0031345|GO:0010810|GO:0051346|GO:0006508|GO:0044267|GO:0007399|GO:0051246|GO:0030154|GO:0051960|GO:0033268|GO:0048666|GO:0030182|GO:0008191|GO:0004866|GO:0021953|GO:0010466|GO:0010975|GO:0030162|GO:0052547|GO:0005509|GO:0045861|GO:0045665|GO:0022008|GO:0050767|GO:0010977|GO:0004869|GO:0048699|GO:0010951|GO:0004867|GO:0045664|GO:0052548 locomotion|developmental process|extracellular matrix|growth|synapse|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|neuromuscular junction|regulation of cellular process|excitatory synapse|intracellular organelle|proteinaceous extracellular matrix|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|cellular component organization|cell adhesion|regulation of growth|extracellular space|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|enzyme inhibitor activity|regulation of cell differentiation|cell development|multicellular organism development|negative regulation of cell differentiation|regulation of cell adhesion|regulation of cellular component organization|cation binding|cytoplasm|movement of cell or subcellular component|neuron projection|cell-substrate adhesion|postsynaptic density|negative regulation of cell adhesion|cell communication|negative regulation of molecular function|cell migration|signal transduction|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|protein metabolic process|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of neurogenesis|regulation of cellular protein metabolic process|neuron projection development|regulation of cell projection organization|sarcoplasm|metal ion binding|axon|central nervous system development|peptidase inhibitor activity|negative regulation of cell development|negative regulation of cell-substrate adhesion|negative regulation of cellular protein metabolic process|neuron migration|main axon|negative regulation of cell projection organization|regulation of cell-substrate adhesion|negative regulation of hydrolase activity|proteolysis|cellular protein metabolic process|nervous system development|regulation of protein metabolic process|cell differentiation|regulation of nervous system development|node of Ranvier|neuron development|neuron differentiation|metalloendopeptidase inhibitor activity|endopeptidase inhibitor activity|central nervous system neuron differentiation|negative regulation of peptidase activity|regulation of neuron projection development|regulation of proteolysis|regulation of peptidase activity|calcium ion binding|negative regulation of proteolysis|negative regulation of neuron differentiation|neurogenesis|regulation of neurogenesis|negative regulation of neuron projection development|cysteine-type endopeptidase inhibitor activity|generation of neurons|negative regulation of endopeptidase activity|serine-type endopeptidase inhibitor activity|regulation of neuron differentiation|regulation of endopeptidase activity - - - - 5:136975298-137598379 20 64 81 454 491 472 0.126655104736992 0.368342643962439 0.462475858625734 2.57600226591963 2.5511837974882 2.80132683583755 0.319157869108388 2.64283763308179 -3.04974566922926 2.95880727632459e-17 1.73540731684468e-15 DOWN ENSG00000107745 MICU1 mitochondrial calcium uptake 1 [Source:HGNC Symbol;Acc:HGNC:1530] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0043229|GO:0006950|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0042802|GO:0019866|GO:0006810|GO:0006952|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0005758|GO:0042592|GO:0046983|GO:0031966|GO:0019725|GO:1902495|GO:0055085|GO:0051649|GO:0016021|GO:0031301|GO:0005740|GO:0046872|GO:1990246|GO:0046982|GO:0048878|GO:0046907|GO:0006811|GO:0055082|GO:0005743|GO:0034702|GO:0005739|GO:0006461|GO:0032592|GO:0034220|GO:0036444|GO:0098655|GO:0051259|GO:0006839|GO:0034703|GO:0006812|GO:0005509|GO:0050801|GO:0006873|GO:0006851|GO:0034704|GO:0030001|GO:0051260|GO:0030003|GO:0070588|GO:0055065|GO:0006875|GO:0006874|GO:0006816|GO:0055074|GO:0051560|GO:0070509|GO:0051561 macromolecular complex|cell|membrane|cellular process|response to stimulus|binding|intracellular organelle|response to stress|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|organelle membrane|identical protein binding|organelle inner membrane|transport|defense response|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|mitochondrial intermembrane space|homeostatic process|protein dimerization activity|mitochondrial membrane|cellular homeostasis|transmembrane transporter complex|transmembrane transport|establishment of localization in cell|integral component of membrane|integral component of organelle membrane|mitochondrial envelope|metal ion binding|uniplex complex|protein heterodimerization activity|chemical homeostasis|intracellular transport|ion transport|cellular chemical homeostasis|mitochondrial inner membrane|ion channel complex|mitochondrion|protein complex assembly|integral component of mitochondrial membrane|ion transmembrane transport|calcium ion transmembrane import into mitochondrion|cation transmembrane transport|protein oligomerization|mitochondrial transport|cation channel complex|cation transport|calcium ion binding|ion homeostasis|cellular ion homeostasis|mitochondrial calcium ion transport|calcium channel complex|metal ion transport|protein homooligomerization|cellular cation homeostasis|calcium ion transmembrane transport|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|mitochondrial calcium ion homeostasis|calcium ion import|positive regulation of mitochondrial calcium ion concentration - - - - 10:72367327-72626191 232 274 417 1019 1426 1342 2.0694806728072 2.22127626351388 3.35368812420117 8.14412873218929 10.4366226867204 11.2189926788728 2.54814835350742 9.93324803259416 -1.9628162619922 3.08634164600389e-17 1.80665967646667e-15 DOWN ENSG00000113649 TCERG1 transcription elongation regulator 1 [Source:HGNC Symbol;Acc:HGNC:15630] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0070064|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0001076|GO:0009890|GO:0006139|GO:0008134|GO:0044249|GO:0031324|GO:0031323|GO:0003713|GO:0005730|GO:0010468|GO:0034645|GO:0003714|GO:0003723|GO:0001104|GO:0001085|GO:0010629|GO:0051252|GO:0070491|GO:0031981|GO:0010467|GO:0009059|GO:0001191|GO:0016070|GO:0005856|GO:0005634|GO:0015629|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0001103|GO:0044822|GO:0001106|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|proline-rich region binding|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor activity, RNA polymerase II transcription factor binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription coactivator activity|nucleolus|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|RNA binding|RNA polymerase II transcription cofactor activity|RNA polymerase II transcription factor binding|negative regulation of gene expression|regulation of RNA metabolic process|repressing transcription factor binding|nuclear lumen|gene expression|macromolecule biosynthetic process|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|cytoskeleton|nucleus|actin cytoskeleton|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|RNA polymerase II repressing transcription factor binding|poly(A) RNA binding|RNA polymerase II transcription corepressor activity|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter K12824 transcription elongation regulator 1[-] hsa03040 Spliceosome - Homo sapiens (human) 5:146447311-146511961 509 550 581 1923 2179 1747 2.48447924336275 2.43983418388104 2.55686450172242 8.40996715003217 8.7265483603579 7.99170049858241 2.49372597632207 8.37607200299083 -1.74797090113467 3.20620965989992e-17 1.8731542697975e-15 DOWN ENSG00000141449 GREB1L growth regulation by estrogen in breast cancer-like [Source:HGNC Symbol;Acc:HGNC:31042] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 18:21242242-21525417 15 32 54 247 293 293 0.0823786160478979 0.15972000516539 0.267387271697888 1.21541347741349 1.32027968883926 1.50808940077139 0.169828630970392 1.34792752234138 -2.98859132058589 3.27156538874358e-17 1.9076037717881e-15 DOWN ENSG00000101974 ATP11C ATPase, class VI, type 11C [Source:HGNC Symbol;Acc:HGNC:13554] GO:0032502|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0045321|GO:0043229|GO:0042175|GO:0043167|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:1903706|GO:0045595|GO:0097035|GO:0050867|GO:0006810|GO:0007275|GO:0048513|GO:0043168|GO:0001882|GO:0016817|GO:0045597|GO:0043231|GO:0043169|GO:0005774|GO:0005737|GO:0002696|GO:0001775|GO:0005319|GO:0046649|GO:0050865|GO:0055085|GO:0061024|GO:0005783|GO:0000166|GO:0048869|GO:0016021|GO:0010876|GO:0005768|GO:0051249|GO:0042113|GO:0046872|GO:0035639|GO:0005548|GO:0030097|GO:0030098|GO:0001883|GO:0005773|GO:0016818|GO:0006811|GO:0032549|GO:0051251|GO:0055037|GO:0006869|GO:0017076|GO:0030154|GO:0034220|GO:0015914|GO:0002521|GO:0045332|GO:0006820|GO:0015711|GO:0030183|GO:0000323|GO:0000287|GO:0005524|GO:0030554|GO:0045619|GO:0050871|GO:0050864|GO:0004012|GO:0045621|GO:0016462|GO:0005765|GO:0045577|GO:0002327|GO:0005764|GO:0017111|GO:0045579|GO:0016887|GO:0002329|GO:0042623|GO:0043492 developmental process|transporter activity|immune system process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|leukocyte activation|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of hemopoiesis|regulation of cell differentiation|regulation of membrane lipid distribution|positive regulation of cell activation|transport|multicellular organism development|animal organ development|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|vacuolar membrane|cytoplasm|positive regulation of leukocyte activation|cell activation|lipid transporter activity|lymphocyte activation|regulation of cell activation|transmembrane transport|membrane organization|endoplasmic reticulum|nucleotide binding|cellular developmental process|integral component of membrane|lipid localization|endosome|regulation of lymphocyte activation|B cell activation|metal ion binding|purine ribonucleoside triphosphate binding|phospholipid transporter activity|hemopoiesis|lymphocyte differentiation|purine nucleoside binding|vacuole|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|ribonucleoside binding|positive regulation of lymphocyte activation|recycling endosome|lipid transport|purine nucleotide binding|cell differentiation|ion transmembrane transport|phospholipid transport|leukocyte differentiation|phospholipid translocation|anion transport|organic anion transport|B cell differentiation|lytic vacuole|magnesium ion binding|ATP binding|adenyl nucleotide binding|regulation of lymphocyte differentiation|positive regulation of B cell activation|regulation of B cell activation|phospholipid-translocating ATPase activity|positive regulation of lymphocyte differentiation|pyrophosphatase activity|lysosomal membrane|regulation of B cell differentiation|immature B cell differentiation|lysosome|nucleoside-triphosphatase activity|positive regulation of B cell differentiation|ATPase activity|pre-B cell differentiation|ATPase activity, coupled|ATPase activity, coupled to movement of substances - - - - X:139726346-139945276 143 165 297 853 949 1032 0.743068864960283 0.779213638999804 1.39143324986196 3.97135384592571 4.04600244955827 5.02574687969985 0.971238584607349 4.34770105839461 -2.16235510405568 3.47655410757788e-17 2.02317829098694e-15 DOWN ENSG00000125630 POLR1B polymerase (RNA) I polypeptide B [Source:HGNC Symbol;Acc:HGNC:20454] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0009892|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0001882|GO:0016772|GO:0046483|GO:0007566|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0007565|GO:0017126|GO:0044249|GO:0006996|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0032549|GO:0031981|GO:1990234|GO:0005654|GO:0010467|GO:0006997|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0005736|GO:0045814|GO:0032774|GO:0034660|GO:0040029|GO:0007000|GO:0006351|GO:0006352|GO:0003899|GO:0006360|GO:0006354|GO:0006353|GO:0009303|GO:0006361|GO:0006362|GO:0006363|GO:0001054 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|embryo implantation|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|female pregnancy|nucleologenesis|cellular biosynthetic process|organelle organization|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|ribonucleoside binding|nuclear lumen|transferase complex|nucleoplasm|gene expression|nucleus organization|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|DNA-directed RNA polymerase I complex|negative regulation of gene expression, epigenetic|RNA biosynthetic process|ncRNA metabolic process|regulation of gene expression, epigenetic|nucleolus organization|transcription, DNA-templated|DNA-templated transcription, initiation|DNA-directed RNA polymerase activity|transcription from RNA polymerase I promoter|DNA-templated transcription, elongation|DNA-templated transcription, termination|rRNA transcription|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|RNA polymerase I activity K03002 DNA-directed RNA polymerase I subunit RPA2[2.7.7.6] hsa01100|hsa00230|hsa00240|hsa03020 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|RNA polymerase - Homo sapiens (human) 2:112541915-112577150 193 199 192 936 1124 650 0.797209175358271 0.747048381803953 0.715039546954762 3.46408702922183 3.80933599711413 2.51627236702468 0.753099034705662 3.26323179778688 -2.11538996924636 3.48393901556302e-17 2.02353142744394e-15 DOWN ENSG00000116922 C1orf109 chromosome 1 open reading frame 109 [Source:HGNC Symbol;Acc:HGNC:26039] GO:0005488|GO:0005515 binding|protein binding - - - - 1:37681570-37692249 932 965 706 240 264 196 5.9026527595433 5.55442186232211 4.0313459789876 1.36188483122428 1.37183868282663 1.16336538448312 5.162806866951 1.29902963284468 1.990721288766 3.6788015199328e-17 2.13256195293347e-15 UP ENSG00000059588 TARBP1 TAR (HIV-1) RNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11568] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0008168|GO:0010468|GO:0034645|GO:0003723|GO:0043412|GO:0051252|GO:0001510|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006396|GO:0032774|GO:0034660|GO:2001141|GO:0009451|GO:0030488|GO:0008173|GO:0008757|GO:0006351|GO:0006355|GO:0006400|GO:0006366|GO:0016423|GO:0006357|GO:1903506|GO:0006399|GO:0008175|GO:0008033 cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|macromolecule modification|regulation of RNA metabolic process|RNA methylation|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA processing|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|RNA modification|tRNA methylation|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|tRNA modification|transcription from RNA polymerase II promoter|tRNA (guanine) methyltransferase activity|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|tRNA metabolic process|tRNA methyltransferase activity|tRNA processing - - - - 1:234391313-234479103 320 468 541 1580 1684 1779 2.16072931639893 2.87194713844218 3.29353045317359 9.55883436937385 9.32954172897327 11.25784169001 2.77540230267157 10.0487392627857 -1.85624569442992 3.92241348096932e-17 2.26664002094759e-15 DOWN ENSG00000156650 KAT6B K(lysine) acetyltransferase 6B [Source:HGNC Symbol;Acc:HGNC:17582] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0016746|GO:0032403|GO:0009890|GO:0006139|GO:0008134|GO:0044249|GO:0000786|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0016573|GO:0010628|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0016747|GO:0005694|GO:0006461|GO:0044267|GO:0010467|GO:0031328|GO:0000123|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0006334|GO:0034622|GO:0045892|GO:0032774|GO:2001141|GO:0034728|GO:0043966|GO:1902679|GO:0016407|GO:0006333|GO:0065004|GO:0016410|GO:0031497|GO:0046914|GO:0016568|GO:0006464|GO:0071103|GO:0006351|GO:0006355|GO:0006323|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0018193|GO:0008080|GO:0070776|GO:0008270|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|protein complex binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|nucleosome|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|histone acetylation|positive regulation of gene expression|protein modification process|nuclear lumen|transferase complex|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|chromosome|protein complex assembly|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|histone acetyltransferase complex|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|nucleosome assembly|cellular macromolecular complex assembly|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nucleosome organization|histone H3 acetylation|negative regulation of RNA biosynthetic process|acetyltransferase activity|chromatin assembly or disassembly|protein-DNA complex assembly|N-acyltransferase activity|chromatin assembly|transition metal ion binding|chromatin modification|cellular protein modification process|DNA conformation change|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA packaging|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|N-acetyltransferase activity|MOZ/MORF histone acetyltransferase complex|zinc ion binding|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity - - - - 10:74825582-75032622 237 262 373 1042 1129 1025 0.656123690643319 0.659202111256554 0.931023415342399 2.58465830217605 2.56448197118717 2.65944274349183 0.748783072414091 2.60286100561835 -1.79747854730413 3.92527932883333e-17 2.26664002094759e-15 DOWN ENSG00000227681 RP11-307P5.1 - - - - - - - 6:147660703-147953937 38 42 61 261 302 231 1.99111697328005 2.00004939801549 2.88174892538438 12.253227796727 12.9833621889727 11.3436378774176 2.29097176555997 12.1934092877058 -2.41206997735953 4.19326210562989e-17 2.4167113301443e-15 DOWN ENSG00000249859 PVT1 Pvt1 oncogene (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:9709] - - - - - - 8:127794533-128101253 39 25 32 286 226 201 0.244306442295588 0.142332002890064 0.180732457982739 1.60523225854005 1.16158799709681 1.18005023228223 0.189123634389464 1.31562349597303 -2.79834510860207 4.56964048664303e-17 2.62855582058268e-15 DOWN ENSG00000174720 LARP7 La ribonucleoprotein domain family member 7 [Source:HGNC Symbol;Acc:HGNC:24912] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0030529|GO:0006139|GO:0000166|GO:0005794|GO:0003723|GO:0031981|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0044822 macromolecular complex|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|endomembrane system|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|nucleotide binding|Golgi apparatus|RNA binding|nuclear lumen|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|poly(A) RNA binding - - - - 4:112636964-112657592 132 130 133 673 741 480 1.29432965564182 1.15849033411132 1.17580361745562 5.91265194685732 5.96150692122199 4.41103094484025 1.20954120240292 5.42839660430652 -2.16606621458471 4.57845232693068e-17 2.62855991861901e-15 DOWN ENSG00000235609 AF127936.9 - - - - - - - 21:14818843-15014430 23 11 13 185 138 236 0.274409063793413 0.119276563927751 0.139834930305348 1.9775747957305 1.35085817603384 2.63879412685996 0.177840186008837 1.98907569954143 -3.48344491524285 4.61364718287797e-17 2.64368182337119e-15 DOWN ENSG00000136492 BRIP1 BRCA1 interacting protein C-terminal helicase 1 [Source:HGNC Symbol;Acc:HGNC:20473] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009605|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0042127|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0009991|GO:0051536|GO:0003676|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0031668|GO:0005635|GO:0006139|GO:0007154|GO:0008285|GO:0031965|GO:0000166|GO:0044249|GO:0031323|GO:0006996|GO:0007584|GO:0051276|GO:0003677|GO:0051539|GO:0010468|GO:0000075|GO:0034645|GO:0046872|GO:0000725|GO:0035639|GO:0051252|GO:0001883|GO:0006302|GO:0016818|GO:0031670|GO:0032549|GO:0033273|GO:0031981|GO:0005654|GO:0006259|GO:0010467|GO:0017076|GO:0009059|GO:0031669|GO:0016070|GO:0031667|GO:0005634|GO:0006974|GO:0000724|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0000077|GO:0071295|GO:0006310|GO:0071103|GO:0016462|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:0032392|GO:1903506|GO:0045003|GO:0017111|GO:0016887|GO:0032508|GO:0004386|GO:0003678|GO:0042623|GO:0008026|GO:0008094|GO:0004003 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|response to external stimulus|hydrolase activity|biosynthetic process|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cell proliferation|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|response to extracellular stimulus|iron-sulfur cluster binding|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular response to extracellular stimulus|nuclear envelope|nucleobase-containing compound metabolic process|cell communication|negative regulation of cell proliferation|nuclear membrane|nucleotide binding|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|response to nutrient|chromosome organization|DNA binding|4 iron, 4 sulfur cluster binding|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|metal ion binding|recombinational repair|purine ribonucleoside triphosphate binding|regulation of RNA metabolic process|purine nucleoside binding|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cellular response to nutrient|ribonucleoside binding|response to vitamin|nuclear lumen|nucleoplasm|DNA metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|cellular response to nutrient levels|RNA metabolic process|response to nutrient levels|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|DNA damage checkpoint|cellular response to vitamin|DNA recombination|DNA conformation change|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|DNA geometric change|regulation of nucleic acid-templated transcription|double-strand break repair via synthesis-dependent strand annealing|nucleoside-triphosphatase activity|ATPase activity|DNA duplex unwinding|helicase activity|DNA helicase activity|ATPase activity, coupled|ATP-dependent helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity K15362 fanconi anemia group J protein[3.6.4.12] hsa03460 Fanconi anemia pathway - Homo sapiens (human) 17:61681266-61863521 61 64 62 295 385 297 0.498668583515452 0.475486806085802 0.456963564901047 2.16072372541336 2.58230607604909 2.27543446936858 0.477039651500767 2.33948809027701 -2.29401179129999 4.81750301308395e-17 2.75310794459475e-15 DOWN ENSG00000198408 MGEA5 meningioma expressed antigen 5 (hyaluronidase) [Source:HGNC Symbol;Acc:HGNC:7056] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0016798|GO:0043231|GO:0005737|GO:0019538|GO:0005829|GO:0043412|GO:0030163|GO:0044265|GO:0009100|GO:0036211|GO:0006040|GO:0004553|GO:0044267|GO:0005634|GO:0006516|GO:0006464|GO:0006517|GO:0004415|GO:0006044|GO:0004563|GO:0016231 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|hydrolase activity, acting on glycosyl bonds|intracellular membrane-bounded organelle|cytoplasm|protein metabolic process|cytosol|macromolecule modification|protein catabolic process|cellular macromolecule catabolic process|glycoprotein metabolic process|protein modification process|amino sugar metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|cellular protein metabolic process|nucleus|glycoprotein catabolic process|cellular protein modification process|protein deglycosylation|hyalurononglucosaminidase activity|N-acetylglucosamine metabolic process|beta-N-acetylhexosaminidase activity|beta-N-acetylglucosaminidase activity K15719 protein O-GlcNAcase / histone acetyltransferase[2.3.1.48] hsa04931 Insulin resistance - Homo sapiens (human) 10:101784443-101818465 639 683 1008 2898 2710 3158 4.0637268671912 3.9475193513137 5.77961051010013 16.5127655657681 14.1403812836502 18.8219622989062 4.59695224286834 16.4917030494415 -1.84299080594582 4.82305706110757e-17 2.75310794459475e-15 DOWN ENSG00000065320 NTN1 netrin 1 [Source:HGNC Symbol;Acc:HGNC:8029] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0005604|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0005578|GO:0016049|GO:0051641|GO:0048870|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0040008|GO:0009605|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0048856|GO:0008284|GO:0051272|GO:0042127|GO:0016337|GO:0006935|GO:0045595|GO:0035239|GO:0051640|GO:0009888|GO:0048468|GO:0035295|GO:0051130|GO:0048839|GO:0007275|GO:0045596|GO:0048513|GO:0032535|GO:0030307|GO:0051128|GO:2000147|GO:0022607|GO:0098609|GO:0045597|GO:0030308|GO:0005737|GO:0007423|GO:0006928|GO:0009887|GO:0051656|GO:0048729|GO:0048598|GO:0048568|GO:0048639|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0048638|GO:0051649|GO:0008219|GO:0048640|GO:0030030|GO:0048869|GO:2000145|GO:0001558|GO:0048732|GO:0060560|GO:0050768|GO:0000902|GO:0031175|GO:0031344|GO:0030879|GO:0002009|GO:0043583|GO:0010720|GO:0010721|GO:0031346|GO:0022612|GO:0000904|GO:0009790|GO:0030334|GO:0030517|GO:0001764|GO:0031345|GO:0042472|GO:0050769|GO:0030031|GO:0008361|GO:0022604|GO:0051647|GO:0012501|GO:0060429|GO:0035556|GO:0006929|GO:0030516|GO:0032990|GO:0048562|GO:0007399|GO:0060562|GO:0097485|GO:0010770|GO:0030154|GO:0048858|GO:1990138|GO:0040023|GO:0051960|GO:0045773|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0006930|GO:0060603|GO:0010769|GO:0061564|GO:0042471|GO:0045665|GO:0050772|GO:0022008|GO:0048667|GO:0007264|GO:0061180|GO:0050767|GO:0048812|GO:0060443|GO:0010976|GO:0010977|GO:0006915|GO:0050771|GO:0048675|GO:0045666|GO:0007265|GO:0007409|GO:0048699|GO:0050770|GO:0045664|GO:0033564|GO:0007266|GO:0032488 locomotion|developmental process|extracellular matrix|growth|signaling|cell|cellular process|extracellular region|response to stimulus|binding|basement membrane|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|cell growth|cellular localization|cell motility|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|regulation of growth|response to external stimulus|regulation of developmental process|developmental growth|intracellular|protein binding|anatomical structure development|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|single organismal cell-cell adhesion|chemotaxis|regulation of cell differentiation|tube morphogenesis|organelle localization|tissue development|cell development|tube development|positive regulation of cellular component organization|inner ear development|multicellular organism development|negative regulation of cell differentiation|animal organ development|regulation of cellular component size|positive regulation of cell growth|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|cell-cell adhesion|positive regulation of cell differentiation|negative regulation of cell growth|cytoplasm|sensory organ development|movement of cell or subcellular component|organ morphogenesis|establishment of organelle localization|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|positive regulation of developmental growth|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|regulation of developmental growth|establishment of localization in cell|cell death|negative regulation of developmental growth|cell projection organization|cellular developmental process|regulation of cell motility|regulation of cell growth|gland development|developmental growth involved in morphogenesis|negative regulation of neurogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|mammary gland development|morphogenesis of an epithelium|ear development|positive regulation of cell development|negative regulation of cell development|positive regulation of cell projection organization|gland morphogenesis|cell morphogenesis involved in differentiation|embryo development|regulation of cell migration|negative regulation of axon extension|neuron migration|negative regulation of cell projection organization|inner ear morphogenesis|positive regulation of neurogenesis|cell projection assembly|regulation of cell size|regulation of cell morphogenesis|nucleus localization|programmed cell death|epithelium development|intracellular signal transduction|substrate-dependent cell migration|regulation of axon extension|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|neuron projection guidance|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|cell projection morphogenesis|neuron projection extension|establishment of nucleus localization|regulation of nervous system development|positive regulation of axon extension|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|substrate-dependent cell migration, cell extension|mammary gland duct morphogenesis|regulation of cell morphogenesis involved in differentiation|axon development|ear morphogenesis|negative regulation of neuron differentiation|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|mammary gland epithelium development|regulation of neurogenesis|neuron projection morphogenesis|mammary gland morphogenesis|positive regulation of neuron projection development|negative regulation of neuron projection development|apoptotic process|negative regulation of axonogenesis|axon extension|positive regulation of neuron differentiation|Ras protein signal transduction|axonogenesis|generation of neurons|regulation of axonogenesis|regulation of neuron differentiation|anterior/posterior axon guidance|Rho protein signal transduction|Cdc42 protein signal transduction K06843 netrin 1[-] hsa04360 Axon guidance - Homo sapiens (human) 17:9021542-9244000 45 59 140 535 630 608 0.493515656595298 0.588059108112088 1.38429876503545 5.25699753115438 5.66884098778794 6.24911789080334 0.821957843247612 5.72498546991522 -2.80013572397573 5.11219616169752e-17 2.90703817545367e-15 DOWN ENSG00000269378 ITGB1P1 integrin subunit beta 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:3781] - - - - - - 19:14621634-14622242 355 405 591 1678 1729 1624 41.2341123369529 42.7526892720542 61.8913971739384 174.629688102453 164.775074036765 176.784219555815 48.6260662609818 172.062993898344 -1.82313505537483 5.10289368653113e-17 2.90703817545367e-15 DOWN ENSG00000249961 CCDC79 coiled-coil domain containing 79 [Source:HGNC Symbol;Acc:HGNC:26675] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0097159|GO:0043229|GO:0044702|GO:0051321|GO:0051641|GO:0016043|GO:0090220|GO:0005622|GO:0005515|GO:0007049|GO:0051640|GO:0022402|GO:0003676|GO:0051656|GO:0070192|GO:0045141|GO:0007126|GO:0051649|GO:0007059|GO:0006996|GO:0051276|GO:0003677|GO:0007129|GO:0007127|GO:0045132|GO:0005694|GO:0051303|GO:0000781|GO:0045143 reproduction|cell|cellular process|reproductive process|binding|organic cyclic compound binding|intracellular organelle|single organism reproductive process|meiotic cell cycle|cellular localization|cellular component organization|chromosome localization to nuclear envelope involved in homologous chromosome segregation|intracellular|protein binding|cell cycle|organelle localization|cell cycle process|nucleic acid binding|establishment of organelle localization|chromosome organization involved in meiotic cell cycle|meiotic telomere clustering|meiotic nuclear division|establishment of localization in cell|chromosome segregation|organelle organization|chromosome organization|DNA binding|synapsis|meiosis I|meiotic chromosome segregation|chromosome|establishment of chromosome localization|chromosome, telomeric region|homologous chromosome segregation - - - - 16:66754976-66801620 55 58 35 1 2 3 0.945676133816559 0.906335323428787 0.542585912909116 0.0153983455276646 0.0282130125959581 0.0483367127207473 0.798199123384821 0.0306493569481233 4.70281998415393 5.51480649492511e-17 3.13001964067479e-15 UP ENSG00000119917 IFIT3 interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0006955|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0005515|GO:0042802|GO:0042127|GO:0045087|GO:0010941|GO:0003676|GO:0006952|GO:0098542|GO:0043231|GO:0005737|GO:0009615|GO:0060548|GO:0007154|GO:0007165|GO:0008219|GO:0008285|GO:0051607|GO:0010033|GO:0005829|GO:0034340|GO:0003723|GO:0007166|GO:0034097|GO:0043069|GO:0005739|GO:0012501|GO:0071310|GO:0043067|GO:0019221|GO:0071357|GO:0042981|GO:0071345|GO:0043066|GO:0035455|GO:0006915|GO:0035457|GO:0060337 immune system process|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|immune response|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|protein binding|identical protein binding|regulation of cell proliferation|innate immune response|regulation of cell death|nucleic acid binding|defense response|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|response to virus|negative regulation of cell death|cell communication|signal transduction|cell death|negative regulation of cell proliferation|defense response to virus|response to organic substance|cytosol|response to type I interferon|RNA binding|cell surface receptor signaling pathway|response to cytokine|negative regulation of programmed cell death|mitochondrion|programmed cell death|cellular response to organic substance|regulation of programmed cell death|cytokine-mediated signaling pathway|cellular response to type I interferon|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|response to interferon-alpha|apoptotic process|cellular response to interferon-alpha|type I interferon signaling pathway - - - - 10:89327894-89340971 237 283 285 72 58 59 6.35023349228312 6.89141549736157 6.88494098727663 1.72852013305606 1.27508112354891 1.48157295247658 6.70886332564044 1.49505806969385 2.16586683173774 5.66976419097747e-17 3.21186224207669e-15 UP ENSG00000158987 RAPGEF6 Rap guanine nucleotide exchange factor 6 [Source:HGNC Symbol;Acc:HGNC:20655] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0045177|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0005085|GO:0019222|GO:0016324|GO:0043168|GO:0005543|GO:0031982|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0030742|GO:0043085|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0050790|GO:0030030|GO:0010256|GO:0005829|GO:0031410|GO:0051345|GO:0032528|GO:0007009|GO:0016023|GO:0072657|GO:0030031|GO:0031988|GO:0034613|GO:0035556|GO:0070300|GO:0051020|GO:0030033|GO:0030139|GO:0072659|GO:0043087|GO:0043547|GO:0031267|GO:0007264|GO:1990778|GO:0007265|GO:0017016 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|ion binding|cellular localization|apical part of cell|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|regulation of metabolic process|apical plasma membrane|anion binding|phospholipid binding|vesicle|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|GTP-dependent protein binding|positive regulation of catalytic activity|protein localization|cell communication|membrane organization|signal transduction|regulation of catalytic activity|cell projection organization|endomembrane system organization|cytosol|cytoplasmic vesicle|positive regulation of hydrolase activity|microvillus organization|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|protein localization to membrane|cell projection assembly|membrane-bounded vesicle|cellular protein localization|intracellular signal transduction|phosphatidic acid binding|GTPase binding|microvillus assembly|endocytic vesicle|protein localization to plasma membrane|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase binding|small GTPase mediated signal transduction|protein localization to cell periphery|Ras protein signal transduction|Ras GTPase binding K08020 Rap guanine nucleotide exchange factor 6[-] hsa04015 Rap1 signaling pathway - Homo sapiens (human) 5:131423921-131635236 87 123 95 477 629 437 0.343058038394582 0.440792049745438 0.337741683973657 1.68524850109669 2.03500859942008 1.61494718775203 0.373863924037892 1.77840142942293 -2.24999584276005 6.04325926448768e-17 3.41695950912908e-15 DOWN ENSG00000170522 ELOVL6 ELOVL fatty acid elongase 6 [Source:HGNC Symbol;Acc:HGNC:15829] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0006082|GO:0044281|GO:0043231|GO:0031227|GO:0016746|GO:0005737|GO:0051186|GO:0030176|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0031301|GO:0006790|GO:0046486|GO:0006637|GO:0006631|GO:0006638|GO:0016747|GO:0008610|GO:0001676|GO:0009108|GO:0006633|GO:0019752|GO:0006639|GO:0046949|GO:0032787|GO:0030497|GO:0035336|GO:0006641|GO:0042759|GO:0019432|GO:0019367|GO:0035338 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|transferase activity, transferring acyl groups|cytoplasm|cofactor metabolic process|integral component of endoplasmic reticulum membrane|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|integral component of organelle membrane|sulfur compound metabolic process|glycerolipid metabolic process|acyl-CoA metabolic process|fatty acid metabolic process|neutral lipid metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|lipid biosynthetic process|long-chain fatty acid metabolic process|coenzyme biosynthetic process|fatty acid biosynthetic process|carboxylic acid metabolic process|acylglycerol metabolic process|fatty-acyl-CoA biosynthetic process|monocarboxylic acid metabolic process|fatty acid elongation|long-chain fatty-acyl-CoA metabolic process|triglyceride metabolic process|long-chain fatty acid biosynthetic process|triglyceride biosynthetic process|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process K10203 elongation of very long chain fatty acids protein 6[2.3.1.199] hsa01212|hsa00062|hsa01040 Fatty acid metabolism - Homo sapiens (human)|Fatty acid elongation - Homo sapiens (human)|Biosynthesis of unsaturated fatty acids - Homo sapiens (human) 4:110045846-110199199 255 296 449 1275 1375 1131 1.64040440284133 1.73054214399823 2.60418131506515 7.34884158327595 7.25740923686497 6.81871837638714 1.99170928730157 7.14165639884269 -1.84225163932096 6.53233727926727e-17 3.68651034282127e-15 DOWN ENSG00000123219 CENPK centromere protein K [Source:HGNC Symbol;Acc:HGNC:29479] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0000776|GO:0022607|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0006996|GO:0051276|GO:0005829|GO:0006325|GO:0000278|GO:0031981|GO:0005654|GO:0005694|GO:0006461|GO:0035556|GO:0005634|GO:0000777|GO:0006334|GO:0034622|GO:0000793|GO:0034728|GO:0034508|GO:0006333|GO:0065004|GO:0031497|GO:0016568|GO:0007264|GO:0071103|GO:0000775|GO:0006336|GO:0006323|GO:0043486|GO:0000779|GO:0006338|GO:0034080|GO:0043044 macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|kinetochore|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|organelle organization|chromosome organization|cytosol|chromatin organization|mitotic cell cycle|nuclear lumen|nucleoplasm|chromosome|protein complex assembly|intracellular signal transduction|nucleus|condensed chromosome kinetochore|nucleosome assembly|cellular macromolecular complex assembly|condensed chromosome|nucleosome organization|centromere complex assembly|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|chromatin modification|small GTPase mediated signal transduction|DNA conformation change|chromosome, centromeric region|DNA replication-independent nucleosome assembly|DNA packaging|histone exchange|condensed chromosome, centromeric region|chromatin remodeling|CENP-A containing nucleosome assembly|ATP-dependent chromatin remodeling - - - - 5:65517766-65563171 114 134 129 536 669 473 0.946926226137177 1.01156628447573 0.966079742641846 3.98907736841787 4.55936593534981 3.68214026558046 0.974857417751584 4.07686118978271 -2.06419570492454 6.55178521630977e-17 3.69050935561721e-15 DOWN ENSG00000100441 KHNYN KH and NYN domain containing [Source:HGNC Symbol;Acc:HGNC:20166] GO:0005488|GO:0097159|GO:0003676|GO:0003723 binding|organic cyclic compound binding|nucleic acid binding|RNA binding - - - - 14:24429286-24441834 93 111 273 925 1045 1364 0.591912860216789 0.642065948842413 1.56658037887381 5.27490849881723 5.45706857092671 8.13614449271389 0.933519729311004 6.28937385415261 -2.75216397681491 7.2850614392832e-17 4.09582343141922e-15 DOWN ENSG00000198718 FAM179B family with sequence similarity 179 member B [Source:HGNC Symbol;Acc:HGNC:19959] GO:0005488 binding - - - - 14:44962208-45074431 130 145 179 606 590 677 0.436894752420888 0.442877671328532 0.542377942788859 1.8247583768292 1.6268786322757 2.13232093124037 0.474050122179426 1.86131931344842 -1.97321406309186 7.67068064829225e-17 4.3045206780849e-15 DOWN ENSG00000258366 RTEL1 regulator of telomere elongation helicase 1 [Source:HGNC Symbol;Acc:HGNC:15888] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0032205|GO:0006281|GO:0006725|GO:0051130|GO:1901360|GO:0051536|GO:0003676|GO:0034641|GO:0043168|GO:0032204|GO:0044281|GO:0001882|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0016817|GO:0032206|GO:0043231|GO:0000723|GO:0043169|GO:0042592|GO:0006139|GO:0000166|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:1904506|GO:0051539|GO:0034645|GO:0051053|GO:0046872|GO:0000725|GO:0010833|GO:0035639|GO:0090656|GO:0001883|GO:0006302|GO:0016818|GO:1904358|GO:0032549|GO:1904535|GO:0031981|GO:2001020|GO:0005654|GO:0006259|GO:0006282|GO:0051054|GO:0033043|GO:1904430|GO:0017076|GO:1904355|GO:1904356|GO:0009059|GO:0016233|GO:0005634|GO:0006974|GO:0090657|GO:0043247|GO:0010638|GO:2001252|GO:0000724|GO:0032200|GO:0006260|GO:2001251|GO:0005524|GO:0030554|GO:0033044|GO:2000779|GO:0000018|GO:0006310|GO:0071103|GO:0016462|GO:0010569|GO:0032392|GO:0045003|GO:0017111|GO:0016887|GO:0032508|GO:0004386|GO:0003678|GO:0042623|GO:0008026|GO:0008094|GO:0004003 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|regulation of metabolic process|negative regulation of telomere maintenance|DNA repair|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|iron-sulfur cluster binding|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|regulation of telomere maintenance|small molecule metabolic process|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|hydrolase activity, acting on acid anhydrides|positive regulation of telomere maintenance|intracellular membrane-bounded organelle|telomere maintenance|cation binding|homeostatic process|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|negative regulation of telomere maintenance in response to DNA damage|4 iron, 4 sulfur cluster binding|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|metal ion binding|recombinational repair|telomere maintenance via telomere lengthening|purine ribonucleoside triphosphate binding|t-circle formation|purine nucleoside binding|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|positive regulation of telomere maintenance via telomere lengthening|ribonucleoside binding|positive regulation of telomeric loop disassembly|nuclear lumen|regulation of response to DNA damage stimulus|nucleoplasm|DNA metabolic process|regulation of DNA repair|positive regulation of DNA metabolic process|regulation of organelle organization|negative regulation of t-circle formation|purine nucleotide binding|positive regulation of telomere capping|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|telomere capping|nucleus|cellular response to DNA damage stimulus|telomeric loop disassembly|telomere maintenance in response to DNA damage|positive regulation of organelle organization|positive regulation of chromosome organization|double-strand break repair via homologous recombination|telomere organization|DNA replication|negative regulation of chromosome organization|ATP binding|adenyl nucleotide binding|regulation of chromosome organization|regulation of double-strand break repair|regulation of DNA recombination|DNA recombination|DNA conformation change|pyrophosphatase activity|regulation of double-strand break repair via homologous recombination|DNA geometric change|double-strand break repair via synthesis-dependent strand annealing|nucleoside-triphosphatase activity|ATPase activity|DNA duplex unwinding|helicase activity|DNA helicase activity|ATPase activity, coupled|ATP-dependent helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity - - - - 20:63657810-63696253 47 43 73 313 353 260 0.356836225280241 0.296703275094758 0.499699224345764 2.12917608937563 2.19893580468376 1.85000320032942 0.384412908240254 2.0593716981296 -2.42147556055211 7.70604913476551e-17 4.31625498816678e-15 DOWN ENSG00000125703 ATG4C autophagy related 4C, cysteine peptidase [Source:HGNC Symbol;Acc:HGNC:16040] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0016787|GO:0009058|GO:0005622|GO:0006810|GO:0022607|GO:0008233|GO:0005737|GO:0045184|GO:0008104|GO:0061024|GO:0000422|GO:0051649|GO:0044804|GO:0016236|GO:0044249|GO:0019538|GO:0006996|GO:0005829|GO:0034645|GO:0090150|GO:1903008|GO:0043412|GO:0007005|GO:0051604|GO:0015031|GO:0036211|GO:0046907|GO:0042157|GO:0072657|GO:0006508|GO:0034613|GO:0070925|GO:0044267|GO:0010467|GO:0009059|GO:0000045|GO:0007033|GO:0016485|GO:0006605|GO:0006886|GO:0004175|GO:0042158|GO:0008234|GO:0006464|GO:0006612|GO:0051697|GO:0004197|GO:0043687|GO:0006497|GO:0006501 cell|cellular process|extracellular region|metabolic process|catalytic activity|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|hydrolase activity|biosynthetic process|intracellular|transport|cellular component assembly|peptidase activity|cytoplasm|establishment of protein localization|protein localization|membrane organization|mitophagy|establishment of localization in cell|nucleophagy|macroautophagy|cellular biosynthetic process|protein metabolic process|organelle organization|cytosol|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|organelle disassembly|macromolecule modification|mitochondrion organization|protein maturation|protein transport|protein modification process|intracellular transport|lipoprotein metabolic process|protein localization to membrane|proteolysis|cellular protein localization|organelle assembly|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|autophagosome assembly|vacuole organization|protein processing|protein targeting|intracellular protein transport|endopeptidase activity|lipoprotein biosynthetic process|cysteine-type peptidase activity|cellular protein modification process|protein targeting to membrane|protein delipidation|cysteine-type endopeptidase activity|post-translational protein modification|protein lipidation|C-terminal protein lipidation K08342 cysteine protease ATG4 [EC:3.4.22.-][-] hsa04140 Regulation of autophagy - Homo sapiens (human) 1:62784135-62865513 43 40 99 384 424 407 0.857060822525596 0.724568070770014 1.77905333242894 6.85754124098843 6.93383271031576 7.60261571506074 1.12022740857485 7.13132988878831 -2.67037951108448 7.88857494126655e-17 4.40388503935735e-15 DOWN ENSG00000140386 SCAPER S-phase cyclin A-associated protein in the ER [Source:HGNC Symbol;Acc:HGNC:13081] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0012505|GO:0003676|GO:0043231|GO:0043169|GO:0005737|GO:0005783|GO:0046872|GO:0005634|GO:0046914|GO:0008270 cell|binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|endomembrane system|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|endoplasmic reticulum|metal ion binding|nucleus|transition metal ion binding|zinc ion binding - - - - 15:76347904-76905444 15 19 46 218 218 288 0.0634136131183914 0.073003177394226 0.175336101093419 0.825757652450732 0.756175006370374 1.14108846750517 0.103917630535345 0.907673708775425 -3.12673332877158 7.89200273349026e-17 4.40388503935735e-15 DOWN ENSG00000095787 WAC WW domain containing adaptor with coiled-coil [Source:HGNC Symbol;Acc:HGNC:17327] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0007049|GO:0010506|GO:0006725|GO:0022402|GO:1901360|GO:0009991|GO:0016570|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0010508|GO:0030529|GO:0032403|GO:0003682|GO:0010646|GO:0006139|GO:0007154|GO:0016236|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0010468|GO:0000075|GO:0034645|GO:0043412|GO:0030163|GO:0051252|GO:0006325|GO:0044265|GO:0010628|GO:0036211|GO:0032269|GO:0016239|GO:0016241|GO:0070063|GO:0031981|GO:0005681|GO:0006508|GO:0016574|GO:0005654|GO:0044267|GO:0042176|GO:0010467|GO:0000993|GO:0031328|GO:0051246|GO:0009059|GO:0016070|GO:0042177|GO:0031667|GO:0010557|GO:0005634|GO:0006974|GO:0044257|GO:0045893|GO:0010498|GO:0032774|GO:1903363|GO:0030162|GO:2001141|GO:0043175|GO:0000077|GO:0016604|GO:0010390|GO:0051603|GO:0045861|GO:0016568|GO:0033523|GO:0006464|GO:0006351|GO:0006355|GO:0016607|GO:0019941|GO:1903506|GO:0044783|GO:0071894|GO:1901799|GO:1903051|GO:0061136|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0032435|GO:0016567|GO:0006513 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cell cycle|regulation of autophagy|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|response to extracellular stimulus|histone modification|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|positive regulation of autophagy|intracellular ribonucleoprotein complex|protein complex binding|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|macroautophagy|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|macromolecule modification|protein catabolic process|regulation of RNA metabolic process|chromatin organization|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|positive regulation of macroautophagy|regulation of macroautophagy|RNA polymerase binding|nuclear lumen|spliceosomal complex|proteolysis|histone ubiquitination|nucleoplasm|cellular protein metabolic process|regulation of protein catabolic process|gene expression|RNA polymerase II core binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|negative regulation of protein catabolic process|response to nutrient levels|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|cellular protein catabolic process|positive regulation of transcription, DNA-templated|proteasomal protein catabolic process|RNA biosynthetic process|negative regulation of cellular protein catabolic process|regulation of proteolysis|regulation of RNA biosynthetic process|RNA polymerase core enzyme binding|DNA damage checkpoint|nuclear body|histone monoubiquitination|proteolysis involved in cellular protein catabolic process|negative regulation of proteolysis|chromatin modification|histone H2B ubiquitination|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|G1 DNA damage checkpoint|histone H2B conserved C-terminal lysine ubiquitination|negative regulation of proteasomal protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|protein monoubiquitination - - - - 10:28532493-28623112 391 531 718 1971 2282 1966 1.31398713483947 1.62176767678482 2.17546866184964 5.934698120822 6.29213235498798 6.19193953625764 1.70374115782464 6.13959000402254 -1.84943614734335 8.13988205139028e-17 4.53373206645906e-15 DOWN ENSG00000261578 RP11-21L23.2 - - - - - - - 11:76800364-76804555 41 48 46 270 300 559 0.691851558503581 0.736114145943544 0.699838655413904 4.08212145513763 4.15349967111005 8.84026378141005 0.709268119953676 5.69196163588591 -3.00452292987352 8.16027705530204e-17 4.53662776925488e-15 DOWN ENSG00000251369 ZNF550 zinc finger protein 550 [Source:HGNC Symbol;Acc:HGNC:28643] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57535257-57559863 1640 1790 1836 496 565 677 11.3444563242569 11.2531187580839 11.4505606338445 3.07410648184874 3.20668315822603 4.38891951503494 11.3493785720618 3.5565697183699 1.67405495618862 8.49785531701765e-17 4.7155199374395e-15 UP ENSG00000078142 PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 [Source:HGNC Symbol;Acc:HGNC:8974] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0030496|GO:0051716|GO:0019898|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0005929|GO:0060341|GO:0002757|GO:0051726|GO:0007049|GO:0044255|GO:0045087|GO:0006810|GO:0022402|GO:0005930|GO:0009991|GO:0051302|GO:0043168|GO:0044281|GO:0032940|GO:0006952|GO:0001882|GO:0016772|GO:0031982|GO:0019637|GO:0033554|GO:0022607|GO:0043231|GO:0010243|GO:0005737|GO:0002218|GO:0031668|GO:0032880|GO:0005942|GO:0045184|GO:0050776|GO:0008104|GO:0007154|GO:0006629|GO:0007165|GO:0050778|GO:0051649|GO:0009725|GO:0016236|GO:0030242|GO:0000166|GO:0051301|GO:0044249|GO:0019538|GO:0010033|GO:0010256|GO:0042594|GO:0005768|GO:0006996|GO:0016192|GO:0005829|GO:0008654|GO:0046486|GO:0007166|GO:0035032|GO:0035639|GO:0043412|GO:0002758|GO:0031410|GO:0001883|GO:0051223|GO:0051604|GO:0015031|GO:1901652|GO:0005773|GO:0071417|GO:0043200|GO:0016023|GO:0036211|GO:0070201|GO:0046907|GO:0032549|GO:0032465|GO:0051046|GO:0005770|GO:0043434|GO:1990234|GO:0007031|GO:0010564|GO:0009306|GO:0006508|GO:0031988|GO:0002764|GO:0009267|GO:0016301|GO:0070925|GO:0006796|GO:0035556|GO:0044267|GO:0010467|GO:0008610|GO:0046903|GO:0071310|GO:0017076|GO:0000407|GO:0031669|GO:0030258|GO:0000045|GO:0007032|GO:0031667|GO:0016773|GO:0032870|GO:0000910|GO:0006644|GO:0045089|GO:0007033|GO:0045088|GO:0034271|GO:0042149|GO:0030139|GO:1901653|GO:0016485|GO:0046474|GO:0005777|GO:0035004|GO:0005524|GO:0050708|GO:0030554|GO:0045022|GO:0016310|GO:0002221|GO:0016482|GO:0048017|GO:0007167|GO:0034272|GO:0005776|GO:0016197|GO:0071375|GO:0004672|GO:0032868|GO:0046834|GO:0006897|GO:0043201|GO:0006464|GO:0006650|GO:0016303|GO:0048015|GO:0002224|GO:0046854|GO:0046488|GO:0006468|GO:0006661|GO:0045335|GO:0032869|GO:0007169|GO:0036092|GO:0034162|GO:0008286 macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|midbody|cellular response to stimulus|extrinsic component of membrane|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|endomembrane system|transferase activity|cilium|regulation of cellular localization|immune response-activating signal transduction|regulation of cell cycle|cell cycle|cellular lipid metabolic process|innate immune response|transport|cell cycle process|axoneme|response to extracellular stimulus|regulation of cell division|anion binding|small molecule metabolic process|secretion by cell|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|activation of innate immune response|cellular response to extracellular stimulus|regulation of protein localization|phosphatidylinositol 3-kinase complex|establishment of protein localization|regulation of immune response|protein localization|cell communication|lipid metabolic process|signal transduction|positive regulation of immune response|establishment of localization in cell|response to hormone|macroautophagy|pexophagy|nucleotide binding|cell division|cellular biosynthetic process|protein metabolic process|response to organic substance|endomembrane system organization|response to starvation|endosome|organelle organization|vesicle-mediated transport|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|cell surface receptor signaling pathway|phosphatidylinositol 3-kinase complex, class III|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|cytoplasmic vesicle|purine nucleoside binding|regulation of protein transport|protein maturation|protein transport|response to peptide|vacuole|cellular response to organonitrogen compound|response to amino acid|cytoplasmic, membrane-bounded vesicle|protein modification process|regulation of establishment of protein localization|intracellular transport|ribonucleoside binding|regulation of cytokinesis|regulation of secretion|late endosome|response to peptide hormone|transferase complex|peroxisome organization|regulation of cell cycle process|protein secretion|proteolysis|membrane-bounded vesicle|immune response-regulating signaling pathway|cellular response to starvation|kinase activity|organelle assembly|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|lipid biosynthetic process|secretion|cellular response to organic substance|purine nucleotide binding|pre-autophagosomal structure|cellular response to nutrient levels|lipid modification|autophagosome assembly|endosome organization|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|cytokinesis|phospholipid metabolic process|positive regulation of innate immune response|vacuole organization|regulation of innate immune response|phosphatidylinositol 3-kinase complex, class III, type I|cellular response to glucose starvation|endocytic vesicle|cellular response to peptide|protein processing|glycerophospholipid biosynthetic process|peroxisome|phosphatidylinositol 3-kinase activity|ATP binding|regulation of protein secretion|adenyl nucleotide binding|early endosome to late endosome transport|phosphorylation|pattern recognition receptor signaling pathway|cytosolic transport|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|phosphatidylinositol 3-kinase complex, class III, type II|autophagosome|endosomal transport|cellular response to peptide hormone stimulus|protein kinase activity|response to insulin|lipid phosphorylation|endocytosis|response to leucine|cellular protein modification process|glycerophospholipid metabolic process|1-phosphatidylinositol-3-kinase activity|phosphatidylinositol-mediated signaling|toll-like receptor signaling pathway|phosphatidylinositol phosphorylation|phosphatidylinositol metabolic process|protein phosphorylation|phosphatidylinositol biosynthetic process|phagocytic vesicle|cellular response to insulin stimulus|transmembrane receptor protein tyrosine kinase signaling pathway|phosphatidylinositol-3-phosphate biosynthetic process|toll-like receptor 9 signaling pathway|insulin receptor signaling pathway K00914 phosphatidylinositol 3-kinase[2.7.1.137] hsa01100|hsa05152|hsa04145|hsa04070|hsa00562|hsa04140 Metabolic pathways - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human)|Regulation of autophagy - Homo sapiens (human) 18:41955206-42087830 106 119 189 611 632 598 0.399599711002451 0.407707278409035 0.642387095490675 2.0637596738131 1.95481511545517 2.1127628664013 0.483231361634054 2.04377921855652 -2.08045336253324 8.66909369682152e-17 4.80161638636196e-15 DOWN ENSG00000175806 MSRA methionine sulfoxide reductase A [Source:HGNC Symbol;Acc:HGNC:7377] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0003824|GO:1903561|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0006082|GO:0044281|GO:0031982|GO:0043231|GO:0005737|GO:0006520|GO:0016667|GO:0006979|GO:0070062|GO:0019538|GO:0006790|GO:0055114|GO:0043412|GO:0036211|GO:0000096|GO:0031981|GO:0005654|GO:0005739|GO:0016671|GO:0044267|GO:0005856|GO:0005634|GO:0015629|GO:0008113|GO:0019752|GO:0006555|GO:0030091|GO:0006464 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|catalytic activity|extracellular vesicle|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|organic acid metabolic process|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|oxidoreductase activity, acting on a sulfur group of donors|response to oxidative stress|extracellular exosome|protein metabolic process|sulfur compound metabolic process|oxidation-reduction process|macromolecule modification|protein modification process|sulfur amino acid metabolic process|nuclear lumen|nucleoplasm|mitochondrion|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|cellular protein metabolic process|cytoskeleton|nucleus|actin cytoskeleton|peptide-methionine (S)-S-oxide reductase activity|carboxylic acid metabolic process|methionine metabolic process|protein repair|cellular protein modification process - - - - 8:10054268-10428891 6 9 6 88 104 64 0.0578518780928286 0.0788735200885353 0.0521630741521648 0.760267540180659 0.822786287904942 0.578360392336038 0.0629628241111762 0.720471406807213 -3.51636901809234 8.9019147238565e-17 4.92144004011133e-15 DOWN ENSG00000196935 SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 [Source:HGNC Symbol;Acc:HGNC:17382] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0048523|GO:0050794|GO:0040012|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0009605|GO:0030234|GO:0005622|GO:0005515|GO:0048856|GO:0006935|GO:0048468|GO:0007275|GO:0008047|GO:0019899|GO:0005737|GO:0006928|GO:0009966|GO:0010646|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0051271|GO:0030030|GO:0048869|GO:2000145|GO:2000146|GO:0000902|GO:0005829|GO:0031175|GO:0005096|GO:0030695|GO:0000904|GO:0030334|GO:0030336|GO:0035556|GO:0032990|GO:0007399|GO:0097485|GO:0051020|GO:0030154|GO:0048858|GO:1902531|GO:0048666|GO:0030182|GO:0007411|GO:0061564|GO:0031267|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0048812|GO:0017016|GO:0007409|GO:0048699|GO:0017048|GO:0048365 locomotion|developmental process|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to external stimulus|enzyme regulator activity|intracellular|protein binding|anatomical structure development|chemotaxis|cell development|multicellular organism development|enzyme activator activity|enzyme binding|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of cellular component movement|cell projection organization|cellular developmental process|regulation of cell motility|negative regulation of cell motility|cell morphogenesis|cytosol|neuron projection development|GTPase activator activity|GTPase regulator activity|cell morphogenesis involved in differentiation|regulation of cell migration|negative regulation of cell migration|intracellular signal transduction|cell part morphogenesis|nervous system development|neuron projection guidance|GTPase binding|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|neuron development|neuron differentiation|axon guidance|axon development|small GTPase binding|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|neuron projection morphogenesis|Ras GTPase binding|axonogenesis|generation of neurons|Rho GTPase binding|Rac GTPase binding K07526 SLIT-ROBO Rho GTPase activating protein[-] hsa04360 Axon guidance - Homo sapiens (human) 12:63844293-64162221 66 111 175 597 684 670 0.131825891216309 0.201494309062109 0.315144959249839 1.06839245238304 1.12094033233832 1.25418665046881 0.216155053176086 1.14783981173006 -2.40878285046869 8.92288764292801e-17 4.92391659319728e-15 DOWN ENSG00000147202 DIAPH2 diaphanous related formin 2 [Source:HGNC Symbol;Acc:HGNC:2877] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0044702|GO:0019953|GO:0003006|GO:0016043|GO:0043227|GO:0032504|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0048609|GO:0007049|GO:0048468|GO:0022402|GO:0007275|GO:0005102|GO:0043231|GO:0019899|GO:0005737|GO:0007154|GO:0007276|GO:0007165|GO:0008092|GO:0051301|GO:0048869|GO:0030029|GO:0007281|GO:0005794|GO:0005768|GO:0006996|GO:0005730|GO:0005829|GO:0007010|GO:0005769|GO:0003779|GO:0048477|GO:0031981|GO:0005739|GO:0030036|GO:0035556|GO:0051020|GO:0030154|GO:0007292|GO:0000910|GO:0005634|GO:0031267|GO:0007264|GO:0007015|GO:0017016|GO:0017048 developmental process|reproduction|signaling|cell|cellular process|reproductive process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|single organism reproductive process|sexual reproduction|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|intracellular|protein binding|endomembrane system|anatomical structure development|multicellular organismal reproductive process|cell cycle|cell development|cell cycle process|multicellular organism development|receptor binding|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|cell communication|gamete generation|signal transduction|cytoskeletal protein binding|cell division|cellular developmental process|actin filament-based process|germ cell development|Golgi apparatus|endosome|organelle organization|nucleolus|cytosol|cytoskeleton organization|early endosome|actin binding|oogenesis|nuclear lumen|mitochondrion|actin cytoskeleton organization|intracellular signal transduction|GTPase binding|cell differentiation|female gamete generation|cytokinesis|nucleus|small GTPase binding|small GTPase mediated signal transduction|actin filament organization|Ras GTPase binding|Rho GTPase binding K05741 diaphanous 2[-] hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) X:96684663-97604997 31 24 97 463 539 710 0.181963309502652 0.128030474640915 0.513343637274655 2.43501293873353 2.59585059455758 3.90580056636077 0.274445807139407 2.97888803321729 -3.44018069461589 9.92338724312262e-17 5.46591887004027e-15 DOWN ENSG00000074590 NUAK1 NUAK family, SNF1-like kinase, 1 [Source:HGNC Symbol;Acc:HGNC:14311] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0007155|GO:0043227|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0042127|GO:0002039|GO:0043168|GO:0030155|GO:0001882|GO:0016772|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0050790|GO:0000166|GO:0048869|GO:0019538|GO:0031323|GO:0007568|GO:0005730|GO:0032268|GO:2000772|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0007569|GO:0031981|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:0016773|GO:0005856|GO:0005634|GO:0090398|GO:0006974|GO:0016311|GO:0005524|GO:0030554|GO:0016310|GO:0015630|GO:0004672|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0006468|GO:0043666|GO:0004674|GO:0035303|GO:0035507 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cell adhesion|membrane-bounded organelle|regulation of developmental process|intracellular|protein binding|transferase activity|regulation of metabolic process|regulation of cell proliferation|p53 binding|anion binding|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell communication|signal transduction|regulation of catalytic activity|nucleotide binding|cellular developmental process|protein metabolic process|regulation of cellular metabolic process|aging|nucleolus|regulation of cellular protein metabolic process|regulation of cellular senescence|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|cell aging|nuclear lumen|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|cellular senescence|cellular response to DNA damage stimulus|dephosphorylation|ATP binding|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|protein kinase activity|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|protein phosphorylation|regulation of phosphoprotein phosphatase activity|protein serine/threonine kinase activity|regulation of dephosphorylation|regulation of myosin-light-chain-phosphatase activity - - - - 12:106063340-106140033 51 67 81 293 352 413 0.454813081534123 0.543025676242502 0.651267692996653 2.3411473387277 2.57557005353684 3.45177359578508 0.549702150257759 2.78949699601654 -2.34328296990423 1.01942193533417e-16 5.60475551702877e-15 DOWN ENSG00000106688 SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 [Source:HGNC Symbol;Acc:HGNC:10939] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0036094|GO:1903561|GO:0022857|GO:0043167|GO:0051641|GO:0045177|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0007269|GO:0005515|GO:0005886|GO:0006810|GO:0016324|GO:0043168|GO:0032940|GO:0031982|GO:0022607|GO:0005887|GO:0007267|GO:0043177|GO:1903524|GO:0022891|GO:0031226|GO:0007154|GO:0055085|GO:0070062|GO:0051649|GO:0001505|GO:0002027|GO:0016021|GO:0003013|GO:0006836|GO:0045823|GO:1903825|GO:0006811|GO:0015075|GO:0006461|GO:0031406|GO:0046903|GO:0010460|GO:0008015|GO:0014047|GO:0034220|GO:0008016|GO:0098655|GO:0006820|GO:0015711|GO:0033229|GO:0098656|GO:0051259|GO:0015293|GO:0060047|GO:0008509|GO:0006812|GO:0046942|GO:0046943|GO:0016597|GO:0006865|GO:0005343|GO:0046717|GO:0008324|GO:0015804|GO:0015171|GO:0005283|GO:0015501|GO:0017153|GO:0006835|GO:0003333|GO:0016595|GO:0015807|GO:0042883|GO:0022890|GO:1903712|GO:0008514|GO:0051260|GO:0005310|GO:0007268|GO:0015813|GO:0070779|GO:0015810|GO:0015175|GO:0005313|GO:1902475|GO:0015179|GO:0015077|GO:0046873|GO:0089711|GO:0051938|GO:0015081 transporter activity|signaling|cell|membrane|cellular process|extracellular region|binding|small molecule binding|extracellular vesicle|transmembrane transporter activity|ion binding|cellular localization|apical part of cell|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|neurotransmitter secretion|protein binding|plasma membrane|transport|apical plasma membrane|anion binding|secretion by cell|vesicle|cellular component assembly|integral component of plasma membrane|cell-cell signaling|organic acid binding|positive regulation of blood circulation|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|cell communication|transmembrane transport|extracellular exosome|establishment of localization in cell|regulation of neurotransmitter levels|regulation of heart rate|integral component of membrane|circulatory system process|neurotransmitter transport|positive regulation of heart contraction|organic acid transmembrane transport|ion transport|ion transmembrane transporter activity|protein complex assembly|carboxylic acid binding|secretion|positive regulation of heart rate|blood circulation|glutamate secretion|ion transmembrane transport|regulation of heart contraction|cation transmembrane transport|anion transport|organic anion transport|cysteine transmembrane transporter activity|anion transmembrane transport|protein oligomerization|symporter activity|heart contraction|anion transmembrane transporter activity|cation transport|carboxylic acid transport|carboxylic acid transmembrane transporter activity|amino acid binding|amino acid transport|organic acid:sodium symporter activity|acid secretion|cation transmembrane transporter activity|neutral amino acid transport|amino acid transmembrane transporter activity|sodium:amino acid symporter activity|glutamate:sodium symporter activity|sodium:dicarboxylate symporter activity|dicarboxylic acid transport|amino acid transmembrane transport|glutamate binding|L-amino acid transport|cysteine transport|inorganic cation transmembrane transporter activity|cysteine transmembrane transport|organic anion transmembrane transporter activity|protein homooligomerization|dicarboxylic acid transmembrane transporter activity|synaptic transmission|L-glutamate transport|D-aspartate import|aspartate transport|neutral amino acid transmembrane transporter activity|L-glutamate transmembrane transporter activity|L-alpha-amino acid transmembrane transport|L-amino acid transmembrane transporter activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|L-glutamate transmembrane transport|L-glutamate import|sodium ion transmembrane transporter activity K05612 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1[-] hsa04724|hsa04974 Glutamatergic synapse - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human) 9:4490444-4587469 33 35 47 190 228 243 0.543114697234247 0.523519310708539 0.697410032879229 2.80176297953148 3.07880874756559 3.7481342746736 0.588014680274005 3.20956866725689 -2.44845534842105 1.03938478505115e-16 5.70400613472741e-15 DOWN ENSG00000164050 PLXNB1 plexin B1 [Source:HGNC Symbol;Acc:HGNC:9103] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0016049|GO:0038023|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0009893|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0042127|GO:0008360|GO:0006935|GO:0045595|GO:0048468|GO:0051130|GO:0007275|GO:0033687|GO:0048513|GO:0005102|GO:0030155|GO:0051128|GO:0005887|GO:0045597|GO:0004888|GO:0043235|GO:0006928|GO:0009966|GO:0032794|GO:0010646|GO:0031226|GO:0043085|GO:0007162|GO:0007154|GO:0051270|GO:0061383|GO:0016477|GO:0007165|GO:0048588|GO:0001503|GO:0060348|GO:0008285|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0006996|GO:0060560|GO:0043931|GO:1902533|GO:0000902|GO:0031175|GO:0031344|GO:0017154|GO:0033688|GO:0007166|GO:0007010|GO:0051345|GO:0010720|GO:0070977|GO:0031346|GO:0000904|GO:0061430|GO:0030334|GO:0050769|GO:0022604|GO:0002116|GO:0035556|GO:0033043|GO:0032990|GO:0030215|GO:0007399|GO:0097485|GO:0010770|GO:0030154|GO:0001501|GO:0048858|GO:1902531|GO:1990138|GO:0033689|GO:0051960|GO:0048666|GO:0030182|GO:1900220|GO:0007411|GO:0010975|GO:0010769|GO:0014068|GO:1902285|GO:0043087|GO:0061564|GO:0048017|GO:0043547|GO:0051493|GO:0014066|GO:0071526|GO:0050772|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0010976|GO:0048675|GO:0045666|GO:0048015|GO:0007409|GO:0048699|GO:1902287|GO:0050770|GO:0045664|GO:0014065 locomotion|developmental process|growth|macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|cell growth|signaling receptor activity|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|regulation of cell shape|chemotaxis|regulation of cell differentiation|cell development|positive regulation of cellular component organization|multicellular organism development|osteoblast proliferation|animal organ development|receptor binding|regulation of cell adhesion|regulation of cellular component organization|integral component of plasma membrane|positive regulation of cell differentiation|transmembrane signaling receptor activity|receptor complex|movement of cell or subcellular component|regulation of signal transduction|GTPase activating protein binding|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|negative regulation of cell adhesion|cell communication|regulation of cellular component movement|trabecula morphogenesis|cell migration|signal transduction|developmental cell growth|ossification|bone development|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|organelle organization|developmental growth involved in morphogenesis|ossification involved in bone maturation|positive regulation of intracellular signal transduction|cell morphogenesis|neuron projection development|regulation of cell projection organization|semaphorin receptor activity|regulation of osteoblast proliferation|cell surface receptor signaling pathway|cytoskeleton organization|positive regulation of hydrolase activity|positive regulation of cell development|bone maturation|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|bone trabecula morphogenesis|regulation of cell migration|positive regulation of neurogenesis|regulation of cell morphogenesis|semaphorin receptor complex|intracellular signal transduction|regulation of organelle organization|cell part morphogenesis|semaphorin receptor binding|nervous system development|neuron projection guidance|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|skeletal system development|cell projection morphogenesis|regulation of intracellular signal transduction|neuron projection extension|negative regulation of osteoblast proliferation|regulation of nervous system development|neuron development|neuron differentiation|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|axon guidance|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|positive regulation of phosphatidylinositol 3-kinase signaling|semaphorin-plexin signaling pathway involved in neuron projection guidance|regulation of GTPase activity|axon development|inositol lipid-mediated signaling|positive regulation of GTPase activity|regulation of cytoskeleton organization|regulation of phosphatidylinositol 3-kinase signaling|semaphorin-plexin signaling pathway|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|axon extension|positive regulation of neuron differentiation|phosphatidylinositol-mediated signaling|axonogenesis|generation of neurons|semaphorin-plexin signaling pathway involved in axon guidance|regulation of axonogenesis|regulation of neuron differentiation|phosphatidylinositol 3-kinase signaling K06821 plexin B[-] hsa04360 Axon guidance - Homo sapiens (human) 3:48403854-48430051 176 208 199 691 757 822 0.742158177491334 0.797124222500534 0.756574186572529 2.61071012657763 2.61907098191371 3.24850806708037 0.765285528854799 2.82609639185724 -1.88474064919678 1.12937842981758e-16 6.18650709060075e-15 DOWN ENSG00000184985 SORCS2 sortilin-related VPS10 domain containing receptor 2 [Source:HGNC Symbol;Acc:HGNC:16698] GO:0004871|GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0031224|GO:0005515|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0008528|GO:0004930|GO:0008188|GO:0007218 signal transducer activity|signaling|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|intrinsic component of membrane|protein binding|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|G-protein coupled peptide receptor activity|G-protein coupled receptor activity|neuropeptide receptor activity|neuropeptide signaling pathway - - - - 4:7192538-7742836 34 32 49 236 240 407 0.241449017381328 0.206524813425381 0.313725973828768 1.50159303980691 1.39837246474294 2.70873237353183 0.253899934878492 1.86956595936056 -2.88037144113486 1.21029795789166e-16 6.617625500897e-15 DOWN ENSG00000047346 FAM214A family with sequence similarity 214 member A [Source:HGNC Symbol;Acc:HGNC:25609] GO:0005488|GO:0005515 binding|protein binding - - - - 15:52581317-52709817 107 116 141 479 505 574 0.545345894565358 0.537310111763964 0.647919281814145 2.18736469244089 2.11177026270124 2.74175466430128 0.576858429381156 2.34696320648114 -2.02450601864988 1.21855505071228e-16 6.65059277586186e-15 DOWN ENSG00000119522 DENND1A DENN/MADD domain containing 1A [Source:HGNC Symbol;Acc:HGNC:29324] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0051641|GO:0023051|GO:0044297|GO:0043227|GO:0071944|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0005085|GO:0097060|GO:0031090|GO:0019222|GO:0051640|GO:0043025|GO:0006810|GO:0031982|GO:0043231|GO:0005737|GO:0042734|GO:0012506|GO:0005088|GO:0051656|GO:0043005|GO:0009966|GO:0045184|GO:0036477|GO:0019904|GO:0010646|GO:0043085|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0050790|GO:0016192|GO:0051650|GO:0031410|GO:0051345|GO:0017124|GO:0015031|GO:0048489|GO:0017112|GO:0016023|GO:0030665|GO:0046907|GO:0030425|GO:0031988|GO:0035556|GO:0030659|GO:0051648|GO:1902531|GO:0043087|GO:0016482|GO:0043547|GO:0030135|GO:0036465|GO:0006897|GO:0051056|GO:0007264|GO:0030136|GO:0007265|GO:0046578|GO:0048488|GO:0006898|GO:0032482|GO:0072583|GO:0032483 synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|cellular localization|regulation of signaling|cell body|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|synaptic membrane|organelle membrane|regulation of metabolic process|organelle localization|neuronal cell body|transport|vesicle|intracellular membrane-bounded organelle|cytoplasm|presynaptic membrane|vesicle membrane|Ras guanyl-nucleotide exchange factor activity|establishment of organelle localization|neuron projection|regulation of signal transduction|establishment of protein localization|somatodendritic compartment|protein domain specific binding|regulation of cell communication|positive regulation of catalytic activity|protein localization|cell communication|signal transduction|establishment of localization in cell|regulation of catalytic activity|vesicle-mediated transport|establishment of vesicle localization|cytoplasmic vesicle|positive regulation of hydrolase activity|SH3 domain binding|protein transport|synaptic vesicle transport|Rab guanyl-nucleotide exchange factor activity|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|intracellular transport|dendrite|membrane-bounded vesicle|intracellular signal transduction|cytoplasmic vesicle membrane|vesicle localization|regulation of intracellular signal transduction|regulation of GTPase activity|cytosolic transport|positive regulation of GTPase activity|coated vesicle|synaptic vesicle recycling|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|clathrin-coated vesicle|Ras protein signal transduction|regulation of Ras protein signal transduction|synaptic vesicle endocytosis|receptor-mediated endocytosis|Rab protein signal transduction|clathrin-mediated endocytosis|regulation of Rab protein signal transduction - - - - 9:123379654-123930152 77 71 141 453 539 525 0.465411967899671 0.39002212016336 0.768390302682947 2.45326261630432 2.67304071733858 2.97397149122677 0.541274796915326 2.70009160828989 -2.31857523633768 1.27238176430586e-16 6.93169437802687e-15 DOWN ENSG00000105137 SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) [Source:HGNC Symbol;Acc:HGNC:25824] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0023051|GO:0009893|GO:0030234|GO:0005622|GO:0019222|GO:0008047|GO:0005737|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005829|GO:0005096|GO:0051345|GO:0030695|GO:0035556|GO:1902531|GO:0043087|GO:0043547|GO:0051056|GO:0007264|GO:0090630 signaling|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of metabolic process|enzyme activator activity|cytoplasm|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cytosol|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|activation of GTPase activity - - - - 19:15107403-15114988 514 530 684 165 185 184 4.08250327195466 3.82577261971958 4.89816447829985 1.1742070547902 1.20559705762301 1.36965287648877 4.26881345665803 1.24981899630066 1.7721159462268 1.32997990910009e-16 7.23228054759089e-15 UP ENSG00000267374 RP11-244M2.1 - - - - - - - 18:39206924-39800318 1 0 1 33 35 55 0.0179383253289262 0 0.016158346722394 0.530157657467041 0.514915372678919 0.924243116926972 0.0113655573504401 0.656438715690977 -5.85191999050048 1.3536157015982e-16 7.34742602827505e-15 DOWN ENSG00000230937 MIR205HG MIR205 host gene [Source:HGNC Symbol;Acc:HGNC:43562] - - - - - - 1:209428820-209432838 596 663 1051 2775 2890 3360 5.35831105053042 5.41719772535345 8.51918706369749 22.3533216890381 21.3180361614143 28.3106379790344 6.43156527986045 23.9939986098289 -1.8994318026147 1.42823632350162e-16 7.73839695132803e-15 DOWN ENSG00000109680 TBC1D19 TBC1 domain family member 19 [Source:HGNC Symbol;Acc:HGNC:25624] GO:0008152|GO:0005488|GO:0009893|GO:0030234|GO:0005515|GO:0019222|GO:0008047|GO:0043085|GO:0050790|GO:0005096|GO:0051345|GO:0030695|GO:0043087|GO:0043547 metabolic process|binding|positive regulation of metabolic process|enzyme regulator activity|protein binding|regulation of metabolic process|enzyme activator activity|positive regulation of catalytic activity|regulation of catalytic activity|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|regulation of GTPase activity|positive regulation of GTPase activity - - - - 4:26576437-26755351 3 3 6 47 77 81 0.047532770284198 0.0432009699653031 0.0857039892453037 0.667145329272825 1.00088477479963 1.2026540969987 0.0588125764982683 0.956894733690385 -4.02416362560492 1.44918298600072e-16 7.83766464928722e-15 DOWN ENSG00000169398 PTK2 protein tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:9611] GO:0040011|GO:0032502|GO:0040007|GO:0004871|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0042995|GO:0097159|GO:0030055|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0045177|GO:0003006|GO:0048870|GO:0023051|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0031252|GO:0002684|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0008284|GO:0051272|GO:0002757|GO:0042127|GO:0044255|GO:0050817|GO:0001890|GO:0016337|GO:0009898|GO:0008360|GO:0006935|GO:0045087|GO:0045595|GO:0051640|GO:0048468|GO:0006810|GO:0001568|GO:0010941|GO:0016324|GO:0005938|GO:0034446|GO:0007275|GO:0010632|GO:0045596|GO:0048513|GO:0005102|GO:0043168|GO:0046620|GO:0097194|GO:0005924|GO:0043062|GO:0006952|GO:0030155|GO:0005912|GO:0001882|GO:0016772|GO:0019637|GO:0031325|GO:0051128|GO:2000147|GO:0022607|GO:0046621|GO:0035265|GO:0098609|GO:0050803|GO:0043231|GO:0048608|GO:0019899|GO:0010243|GO:0005737|GO:0033627|GO:0009611|GO:0071559|GO:0006928|GO:0051963|GO:0009887|GO:0031234|GO:0051656|GO:0001775|GO:0098562|GO:1901888|GO:0031589|GO:0009966|GO:0030027|GO:0019897|GO:0019904|GO:0060548|GO:0010646|GO:0043085|GO:0007162|GO:0050776|GO:0001525|GO:0007163|GO:0007154|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0050778|GO:0030278|GO:0048638|GO:0050808|GO:0001503|GO:0051649|GO:0008092|GO:0009725|GO:0008219|GO:0048640|GO:0050790|GO:0000166|GO:0030030|GO:0048869|GO:2000145|GO:0009967|GO:0007017|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0050878|GO:0006996|GO:0071774|GO:0050768|GO:0000165|GO:0016192|GO:1902533|GO:0032268|GO:0000902|GO:0006909|GO:0005829|GO:0045732|GO:0031175|GO:0031344|GO:0090132|GO:0045216|GO:0030168|GO:0007416|GO:0007166|GO:0035639|GO:0001944|GO:0043412|GO:0007010|GO:0050807|GO:0061458|GO:0072358|GO:0030163|GO:0007417|GO:0043069|GO:0007596|GO:0005815|GO:0001883|GO:0003779|GO:0003007|GO:0010721|GO:0045667|GO:0044265|GO:1901652|GO:0000904|GO:0009790|GO:0071417|GO:0030334|GO:0001667|GO:0090218|GO:0051347|GO:0036211|GO:0032432|GO:0033628|GO:0071560|GO:0007160|GO:0042060|GO:0001764|GO:0032549|GO:0007172|GO:0001649|GO:0031345|GO:0034329|GO:0002429|GO:0022408|GO:0022407|GO:0030010|GO:0043434|GO:0007599|GO:0051964|GO:0044344|GO:0001570|GO:0010810|GO:0051247|GO:0070848|GO:0006508|GO:0022604|GO:0051647|GO:0002764|GO:0006461|GO:0016301|GO:0042641|GO:0019900|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0042169|GO:0033043|GO:0044267|GO:0051174|GO:0042176|GO:0032990|GO:1900024|GO:0007399|GO:0019216|GO:0071310|GO:0097485|GO:0017076|GO:0010594|GO:0030198|GO:0051246|GO:0006921|GO:0030154|GO:0048858|GO:0030335|GO:1902531|GO:0072359|GO:0000226|GO:0016773|GO:0032870|GO:0005856|GO:0005634|GO:0043067|GO:0038096|GO:0006644|GO:0040023|GO:0051960|GO:0005925|GO:0048666|GO:0030182|GO:0051896|GO:0015629|GO:0007411|GO:0043491|GO:0021953|GO:0044257|GO:0010975|GO:0031401|GO:0008543|GO:0034622|GO:1901653|GO:0043408|GO:0010769|GO:0034332|GO:0014068|GO:0043552|GO:1903364|GO:0005524|GO:0043550|GO:0030162|GO:0043623|GO:0045862|GO:0071363|GO:0043087|GO:0030554|GO:0016310|GO:0051897|GO:0007229|GO:0002768|GO:0038179|GO:0007179|GO:0060416|GO:0061564|GO:0048017|GO:0051493|GO:0051603|GO:0007167|GO:0001952|GO:0001725|GO:0007044|GO:0015630|GO:0021954|GO:0071375|GO:0043410|GO:0010631|GO:0042981|GO:0048041|GO:1903725|GO:0043066|GO:0004672|GO:0032868|GO:0002431|GO:0014066|GO:0045665|GO:0006897|GO:0019901|GO:0022008|GO:0048667|GO:0007264|GO:0051893|GO:0006464|GO:0038007|GO:0050767|GO:0048812|GO:0010977|GO:0043549|GO:0006915|GO:0050771|GO:0034333|GO:0033674|GO:0043551|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:1903052|GO:0048015|GO:0045860|GO:0021955|GO:0008432|GO:0007409|GO:0019941|GO:0006468|GO:0048699|GO:2000209|GO:0043405|GO:0042325|GO:0004713|GO:0071378|GO:0001932|GO:0032869|GO:0018193|GO:0038093|GO:0043276|GO:0001934|GO:0007178|GO:0043542|GO:0050770|GO:0045664|GO:0042327|GO:2000811|GO:0007169|GO:0004715|GO:0032446|GO:0048010|GO:0006511|GO:0031398|GO:0038094|GO:2000058|GO:0048013|GO:0046777|GO:0038095|GO:0031396|GO:0060396|GO:0014065|GO:2000060|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0018108|GO:0038083|GO:0007173|GO:0042787|GO:0016567 locomotion|developmental process|growth|signal transducer activity|reproduction|immune system process|signaling|cell|membrane|cellular process|reproductive process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|cell projection|organic cyclic compound binding|cell-substrate junction|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|cellular localization|apical part of cell|developmental process involved in reproduction|cell motility|regulation of signaling|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|cell leading edge|positive regulation of immune system process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|protein binding|plasma membrane|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|positive regulation of cellular component movement|immune response-activating signal transduction|regulation of cell proliferation|cellular lipid metabolic process|coagulation|placenta development|single organismal cell-cell adhesion|cytoplasmic side of plasma membrane|regulation of cell shape|chemotaxis|innate immune response|regulation of cell differentiation|organelle localization|cell development|transport|blood vessel development|regulation of cell death|apical plasma membrane|cell cortex|substrate adhesion-dependent cell spreading|multicellular organism development|regulation of epithelial cell migration|negative regulation of cell differentiation|animal organ development|receptor binding|anion binding|regulation of organ growth|execution phase of apoptosis|cell-substrate adherens junction|extracellular structure organization|defense response|regulation of cell adhesion|adherens junction|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|negative regulation of organ growth|organ growth|cell-cell adhesion|regulation of synapse structure or activity|intracellular membrane-bounded organelle|reproductive structure development|enzyme binding|response to organonitrogen compound|cytoplasm|cell adhesion mediated by integrin|response to wounding|response to transforming growth factor beta|movement of cell or subcellular component|regulation of synapse assembly|organ morphogenesis|extrinsic component of cytoplasmic side of plasma membrane|establishment of organelle localization|cell activation|cytoplasmic side of membrane|regulation of cell junction assembly|cell-substrate adhesion|regulation of signal transduction|lamellipodium|extrinsic component of plasma membrane|protein domain specific binding|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|negative regulation of cell adhesion|regulation of immune response|angiogenesis|establishment or maintenance of cell polarity|cell communication|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|positive regulation of immune response|regulation of ossification|regulation of developmental growth|synapse organization|ossification|establishment of localization in cell|cytoskeletal protein binding|response to hormone|cell death|negative regulation of developmental growth|regulation of catalytic activity|nucleotide binding|cell projection organization|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|organelle organization|response to fibroblast growth factor|negative regulation of neurogenesis|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|phagocytosis|cytosol|positive regulation of protein catabolic process|neuron projection development|regulation of cell projection organization|epithelium migration|cell-cell junction organization|platelet activation|synapse assembly|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|vasculature development|macromolecule modification|cytoskeleton organization|regulation of synapse organization|reproductive system development|cardiovascular system development|protein catabolic process|central nervous system development|negative regulation of programmed cell death|blood coagulation|microtubule organizing center|purine nucleoside binding|actin binding|heart morphogenesis|negative regulation of cell development|regulation of osteoblast differentiation|cellular macromolecule catabolic process|response to peptide|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|regulation of cell migration|ameboidal-type cell migration|positive regulation of lipid kinase activity|positive regulation of transferase activity|protein modification process|actin filament bundle|regulation of cell adhesion mediated by integrin|cellular response to transforming growth factor beta stimulus|cell-matrix adhesion|wound healing|neuron migration|ribonucleoside binding|signal complex assembly|osteoblast differentiation|negative regulation of cell projection organization|cell junction assembly|immune response-activating cell surface receptor signaling pathway|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|establishment of cell polarity|response to peptide hormone|hemostasis|negative regulation of synapse assembly|cellular response to fibroblast growth factor stimulus|vasculogenesis|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|response to growth factor|proteolysis|regulation of cell morphogenesis|nucleus localization|immune response-regulating signaling pathway|protein complex assembly|kinase activity|actomyosin|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|SH2 domain binding|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|cell part morphogenesis|regulation of substrate adhesion-dependent cell spreading|nervous system development|regulation of lipid metabolic process|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|regulation of endothelial cell migration|extracellular matrix organization|regulation of protein metabolic process|cellular component disassembly involved in execution phase of apoptosis|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|regulation of intracellular signal transduction|circulatory system development|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|cytoskeleton|nucleus|regulation of programmed cell death|Fc-gamma receptor signaling pathway involved in phagocytosis|phospholipid metabolic process|establishment of nucleus localization|regulation of nervous system development|focal adhesion|neuron development|neuron differentiation|regulation of protein kinase B signaling|actin cytoskeleton|axon guidance|protein kinase B signaling|central nervous system neuron differentiation|cellular protein catabolic process|regulation of neuron projection development|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular macromolecular complex assembly|cellular response to peptide|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|adherens junction organization|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of cellular protein catabolic process|ATP binding|regulation of lipid kinase activity|regulation of proteolysis|cellular protein complex assembly|positive regulation of proteolysis|cellular response to growth factor stimulus|regulation of GTPase activity|adenyl nucleotide binding|phosphorylation|positive regulation of protein kinase B signaling|integrin-mediated signaling pathway|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|transforming growth factor beta receptor signaling pathway|response to growth hormone|axon development|inositol lipid-mediated signaling|regulation of cytoskeleton organization|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|stress fiber|cell-substrate junction assembly|microtubule cytoskeleton|central nervous system neuron development|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|epithelial cell migration|regulation of apoptotic process|focal adhesion assembly|regulation of phospholipid metabolic process|negative regulation of apoptotic process|protein kinase activity|response to insulin|Fc receptor mediated stimulatory signaling pathway|regulation of phosphatidylinositol 3-kinase signaling|negative regulation of neuron differentiation|endocytosis|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|regulation of focal adhesion assembly|cellular protein modification process|netrin-activated signaling pathway|regulation of neurogenesis|neuron projection morphogenesis|negative regulation of neuron projection development|regulation of kinase activity|apoptotic process|negative regulation of axonogenesis|adherens junction assembly|positive regulation of kinase activity|regulation of phosphatidylinositol 3-kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of proteolysis involved in cellular protein catabolic process|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|central nervous system neuron axonogenesis|JUN kinase binding|axonogenesis|modification-dependent protein catabolic process|protein phosphorylation|generation of neurons|regulation of anoikis|regulation of MAP kinase activity|regulation of phosphorylation|protein tyrosine kinase activity|cellular response to growth hormone stimulus|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|anoikis|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|endothelial cell migration|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|negative regulation of anoikis|transmembrane receptor protein tyrosine kinase signaling pathway|non-membrane spanning protein tyrosine kinase activity|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|Fc-gamma receptor signaling pathway|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ephrin receptor signaling pathway|protein autophosphorylation|Fc-epsilon receptor signaling pathway|regulation of protein ubiquitination|growth hormone receptor signaling pathway|phosphatidylinositol 3-kinase signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation|epidermal growth factor receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination K05725 focal adhesion kinase 1[2.7.10.2] hsa05200|hsa04151|hsa04810|hsa05205|hsa04510|hsa04062|hsa05202|hsa04360|hsa04670|hsa05146|hsa04012|hsa05222|hsa05100|hsa04370 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human) 8:140657900-141002216 644 672 1384 3922 4095 4703 1.46350547399309 1.38789886100332 2.83569102449399 7.98571351040022 7.63537361954917 10.0164165293116 1.89569845316347 8.545834553087 -2.17249189234359 1.65823847945253e-16 8.95208889070088e-15 DOWN ENSG00000144161 ZC3H8 zinc finger CCCH-type containing 8 [Source:HGNC Symbol;Acc:HGNC:30941] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0002683|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0001776|GO:0000785|GO:0007155|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:1903706|GO:0008023|GO:0016337|GO:0045595|GO:0006725|GO:1901360|GO:0010941|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0070489|GO:0034641|GO:0030155|GO:0031325|GO:0046483|GO:0010942|GO:0098609|GO:0043231|GO:0043169|GO:0000981|GO:0042592|GO:0001775|GO:0009890|GO:0006139|GO:0007162|GO:0046649|GO:0050865|GO:0002260|GO:0008219|GO:0002695|GO:0048869|GO:0035327|GO:0044249|GO:0031324|GO:0031323|GO:0009636|GO:0051249|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0003723|GO:0030097|GO:0030098|GO:0010629|GO:0051252|GO:0034109|GO:0010628|GO:0048872|GO:0051250|GO:0022408|GO:0022407|GO:0043029|GO:0031981|GO:0007159|GO:0005654|GO:0005694|GO:0046677|GO:0042110|GO:0012501|GO:0010467|GO:0001227|GO:0031328|GO:0009059|GO:0030154|GO:0043068|GO:0016070|GO:0010557|GO:0005634|GO:0043067|GO:0002521|GO:1903038|GO:0000975|GO:0045893|GO:0050863|GO:0043065|GO:0045892|GO:0045620|GO:0032774|GO:0043565|GO:0034660|GO:0050868|GO:2001141|GO:0030217|GO:0045619|GO:1902679|GO:0016604|GO:0070486|GO:0003690|GO:0033085|GO:0033081|GO:0042981|GO:0033077|GO:0044822|GO:0034111|GO:0006351|GO:0006915|GO:0006355|GO:2000108|GO:0006366|GO:1903507|GO:0035363|GO:0006357|GO:0006383|GO:0015030|GO:0045945|GO:0045580|GO:1903506|GO:0044212|GO:0045581|GO:0006359|GO:0016073|GO:0000122|GO:0071593|GO:0044213|GO:0070230|GO:0000976|GO:0001012|GO:0042796|GO:0009301|GO:0070228|GO:0042795|GO:0070231|GO:0070234|GO:0000977|GO:0001161|GO:0070232|GO:0070242|GO:0001162|GO:0070243|GO:0070245 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|leukocyte homeostasis|chromatin|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|regulation of hemopoiesis|transcription elongation factor complex|single organismal cell-cell adhesion|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell death|cell-cell adhesion|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|homeostatic process|cell activation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|negative regulation of cell adhesion|lymphocyte activation|regulation of cell activation|lymphocyte homeostasis|cell death|negative regulation of leukocyte activation|cellular developmental process|transcriptionally active chromatin|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to toxic substance|regulation of lymphocyte activation|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|hemopoiesis|lymphocyte differentiation|negative regulation of gene expression|regulation of RNA metabolic process|homotypic cell-cell adhesion|positive regulation of gene expression|homeostasis of number of cells|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|T cell homeostasis|nuclear lumen|leukocyte cell-cell adhesion|nucleoplasm|chromosome|response to antibiotic|T cell activation|programmed cell death|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|leukocyte differentiation|negative regulation of leukocyte cell-cell adhesion|regulatory region DNA binding|positive regulation of transcription, DNA-templated|regulation of T cell activation|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|negative regulation of lymphocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|ncRNA metabolic process|negative regulation of T cell activation|regulation of RNA biosynthetic process|T cell differentiation|regulation of lymphocyte differentiation|negative regulation of RNA biosynthetic process|nuclear body|leukocyte aggregation|double-stranded DNA binding|negative regulation of T cell differentiation in thymus|regulation of T cell differentiation in thymus|regulation of apoptotic process|T cell differentiation in thymus|poly(A) RNA binding|negative regulation of homotypic cell-cell adhesion|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of leukocyte apoptotic process|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|histone locus body|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter|Cajal body|positive regulation of transcription from RNA polymerase III promoter|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of T cell differentiation|regulation of transcription from RNA polymerase III promoter|snRNA metabolic process|negative regulation of transcription from RNA polymerase II promoter|lymphocyte aggregation|intronic transcription regulatory region DNA binding|positive regulation of lymphocyte apoptotic process|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|snRNA transcription from RNA polymerase III promoter|snRNA transcription|regulation of lymphocyte apoptotic process|snRNA transcription from RNA polymerase II promoter|T cell apoptotic process|positive regulation of T cell apoptotic process|RNA polymerase II regulatory region sequence-specific DNA binding|intronic transcription regulatory region sequence-specific DNA binding|regulation of T cell apoptotic process|thymocyte apoptotic process|RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding|regulation of thymocyte apoptotic process|positive regulation of thymocyte apoptotic process - - - - 2:112211525-112255136 24 32 32 172 224 156 0.173586070726468 0.210347000667712 0.208673917744488 1.11463414510259 1.32929705603767 1.05744842335698 0.197535663046223 1.16712654149908 -2.56277594277794 1.67028986697509e-16 9.0008725069809e-15 DOWN ENSG00000104047 DTWD1 DTW domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30926] - - - - - - 15:49620980-49656232 27 30 40 206 236 160 0.106782153137862 0.107828416771334 0.142628610729889 0.729956771191079 0.7657941033387 0.593036960678325 0.119079726879695 0.696262611736035 -2.54770373717257 1.70876223295041e-16 9.19160138783814e-15 DOWN ENSG00000102452 NALCN sodium leak channel, non selective [Source:HGNC Symbol;Acc:HGNC:19082] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0022857|GO:0050794|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0042391|GO:0006810|GO:0022891|GO:0055085|GO:0016021|GO:0051899|GO:0001508|GO:0015267|GO:0006811|GO:0015075|GO:0034765|GO:0043269|GO:0034220|GO:0098655|GO:0005216|GO:0086010|GO:0006812|GO:0008324|GO:0005244|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0005272|GO:0035725|GO:0006814|GO:0015077|GO:0046873|GO:0006816|GO:0015081 transporter activity|cell|membrane|cellular process|binding|transmembrane transporter activity|regulation of cellular process|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|regulation of membrane potential|transport|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|membrane depolarization|action potential|channel activity|ion transport|ion transmembrane transporter activity|regulation of ion transmembrane transport|regulation of ion transport|ion transmembrane transport|cation transmembrane transport|ion channel activity|membrane depolarization during action potential|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|sodium channel activity|sodium ion transmembrane transport|sodium ion transport|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|calcium ion transport|sodium ion transmembrane transporter activity - - - - 13:101053776-101416492 67 105 103 396 490 406 0.503172378261833 0.716657515974112 0.697417187045031 2.66461238937785 3.01929269685824 2.85756422416104 0.639082360426992 2.84715643679904 -2.15544799140248 1.77599204351777e-16 9.5360551199963e-15 DOWN ENSG00000119922 IFIT2 interferon induced protein with tetratricopeptide repeats 2 [Source:HGNC Symbol;Acc:HGNC:5409] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0006955|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0005515|GO:0012505|GO:0045087|GO:0010941|GO:0003676|GO:0006952|GO:0010942|GO:0098542|GO:0051098|GO:0043231|GO:0005737|GO:0009615|GO:0007154|GO:0044092|GO:0007165|GO:0005783|GO:0008219|GO:0051607|GO:0010033|GO:0006996|GO:0005829|GO:0034340|GO:0003723|GO:0007166|GO:0051100|GO:0034097|GO:0007005|GO:0012501|GO:0071310|GO:0043068|GO:0043067|GO:0043393|GO:0019221|GO:0043065|GO:0008637|GO:0071357|GO:0042981|GO:0071345|GO:0044822|GO:0035455|GO:0032091|GO:0006915|GO:0035457|GO:0060337 immune system process|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|immune response|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|protein binding|endomembrane system|innate immune response|regulation of cell death|nucleic acid binding|defense response|positive regulation of cell death|defense response to other organism|regulation of binding|intracellular membrane-bounded organelle|cytoplasm|response to virus|cell communication|negative regulation of molecular function|signal transduction|endoplasmic reticulum|cell death|defense response to virus|response to organic substance|organelle organization|cytosol|response to type I interferon|RNA binding|cell surface receptor signaling pathway|negative regulation of binding|response to cytokine|mitochondrion organization|programmed cell death|cellular response to organic substance|positive regulation of programmed cell death|regulation of programmed cell death|regulation of protein binding|cytokine-mediated signaling pathway|positive regulation of apoptotic process|apoptotic mitochondrial changes|cellular response to type I interferon|regulation of apoptotic process|cellular response to cytokine stimulus|poly(A) RNA binding|response to interferon-alpha|negative regulation of protein binding|apoptotic process|cellular response to interferon-alpha|type I interferon signaling pathway - - - - 10:89301955-89309276 512 602 454 133 153 140 5.54883418924206 5.92937286669459 4.43611174729843 1.29146083418949 1.36047767908324 1.42197075802625 5.30477293441169 1.35796975709966 1.96583964916829 1.87634677491439e-16 1.00568144736614e-14 UP ENSG00000103852 TTC23 tetratricopeptide repeat domain 23 [Source:HGNC Symbol;Acc:HGNC:25730] GO:0005488|GO:0005515 binding|protein binding - - - - 15:99136323-99251223 23 26 48 190 219 209 0.103840396938419 0.106680485962204 0.195384206502969 0.768571437709109 0.811232029242626 0.884317315720138 0.135301696467864 0.821373594223958 -2.60185863932281 1.99650153200052e-16 1.06816409921763e-14 DOWN ENSG00000107960 OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1 [Source:HGNC Symbol;Acc:HGNC:26200] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0030234|GO:0032993|GO:0005622|GO:0005515|GO:0019222|GO:0004857|GO:0006725|GO:0051130|GO:1901360|GO:0003676|GO:0034641|GO:0032204|GO:0031325|GO:0046483|GO:0051128|GO:0032206|GO:0043231|GO:0000723|GO:0042592|GO:0009890|GO:0006139|GO:0043085|GO:0044092|GO:0050790|GO:0043086|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0003677|GO:0007004|GO:0034645|GO:0051053|GO:0010833|GO:0051347|GO:1904358|GO:0031981|GO:0010521|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0051054|GO:0033043|GO:0031328|GO:1904356|GO:0009059|GO:0005856|GO:0010557|GO:0005634|GO:0000783|GO:0010638|GO:2001252|GO:0008156|GO:0032200|GO:0006260|GO:0000781|GO:2000279|GO:0051972|GO:0003697|GO:0043565|GO:0051973|GO:0033044|GO:0032212|GO:2000278|GO:1990879|GO:0006275|GO:0045111|GO:0000784|GO:2000573|GO:0045740|GO:0071897|GO:0051974|GO:0032210|GO:0006278|GO:0042162|GO:0043047 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|protein-DNA complex|intracellular|protein binding|regulation of metabolic process|enzyme inhibitor activity|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|regulation of telomere maintenance|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of telomere maintenance|intracellular membrane-bounded organelle|telomere maintenance|homeostatic process|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|DNA binding|telomere maintenance via telomerase|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|telomere maintenance via telomere lengthening|positive regulation of transferase activity|positive regulation of telomere maintenance via telomere lengthening|nuclear lumen|telomerase inhibitor activity|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|positive regulation of DNA metabolic process|regulation of organelle organization|positive regulation of cellular biosynthetic process|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|nuclear telomere cap complex|positive regulation of organelle organization|positive regulation of chromosome organization|negative regulation of DNA replication|telomere organization|DNA replication|chromosome, telomeric region|negative regulation of DNA biosynthetic process|regulation of telomerase activity|single-stranded DNA binding|sequence-specific DNA binding|positive regulation of telomerase activity|regulation of chromosome organization|positive regulation of telomere maintenance via telomerase|regulation of DNA biosynthetic process|CST complex|regulation of DNA replication|intermediate filament cytoskeleton|nuclear chromosome, telomeric region|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|DNA biosynthetic process|negative regulation of telomerase activity|regulation of telomere maintenance via telomerase|RNA-dependent DNA replication|telomeric DNA binding|single-stranded telomeric DNA binding - - - - 10:103882542-103918205 110 141 155 482 632 588 3.35533558820295 3.9088141517062 4.26277034939737 13.1731544049597 15.8172276094872 16.8093505553583 3.84230669643551 15.2665775232684 -1.99033208760403 2.0976310001417e-16 1.1202625380721e-14 DOWN ENSG00000011677 GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 [Source:HGNC Symbol;Acc:HGNC:4077] GO:0032991|GO:0004871|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0051716|GO:0004872|GO:0022857|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0043234|GO:0097060|GO:0030594|GO:0006810|GO:0045211|GO:0005887|GO:0004888|GO:0007267|GO:0043235|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0016021|GO:0007186|GO:0016917|GO:0015267|GO:0006811|GO:0015075|GO:1902710|GO:0034702|GO:0008503|GO:0034220|GO:0015276|GO:0006820|GO:0005216|GO:0098656|GO:0034707|GO:0008509|GO:0004890|GO:0007214|GO:1902711|GO:0005253|GO:0005230|GO:0015698|GO:0007268|GO:0005254|GO:1902476|GO:0006821|GO:0015108 macromolecular complex|signal transducer activity|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|cellular response to stimulus|receptor activity|transmembrane transporter activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|protein complex|synaptic membrane|neurotransmitter receptor activity|transport|postsynaptic membrane|integral component of plasma membrane|transmembrane signaling receptor activity|cell-cell signaling|receptor complex|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|GABA receptor activity|channel activity|ion transport|ion transmembrane transporter activity|GABA receptor complex|ion channel complex|benzodiazepine receptor activity|ion transmembrane transport|ligand-gated ion channel activity|anion transport|ion channel activity|anion transmembrane transport|chloride channel complex|anion transmembrane transporter activity|GABA-A receptor activity|gamma-aminobutyric acid signaling pathway|GABA-A receptor complex|anion channel activity|extracellular ligand-gated ion channel activity|inorganic anion transport|synaptic transmission|chloride channel activity|chloride transmembrane transport|chloride transport|chloride transmembrane transporter activity K05175 gamma-aminobutyric acid receptor subunit alpha[-] hsa04080|hsa04723|hsa05032|hsa04727|hsa04742|hsa05033 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Taste transduction - Homo sapiens (human)|Nicotine addiction - Homo sapiens (human) X:152166234-152451358 3 8 11 77 88 138 0.0447656231425741 0.108478889819143 0.147969879305416 1.02935358683741 1.07727386968225 1.92966908460905 0.100404797422378 1.34543218037624 -3.74416956124433 2.26019486435368e-16 1.20492602643598e-14 DOWN ENSG00000137776 SLTM SAFB-like, transcription modulator [Source:HGNC Symbol;Acc:HGNC:20709] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0008219|GO:0000166|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0003723|GO:0051252|GO:0031981|GO:0005654|GO:0012501|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0044822|GO:0006351|GO:0006915|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cell death|nucleotide binding|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|programmed cell death|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|poly(A) RNA binding|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 15:58879045-58933653 497 592 532 1909 2000 1784 2.08246677991269 2.25436226040308 2.00977703670495 7.1668034664129 6.87574662752781 7.00560649142186 2.11553535900691 7.01605219512086 -1.72963668152208 2.31661269606164e-16 1.23280134453163e-14 DOWN ENSG00000125968 ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein [Source:HGNC Symbol;Acc:HGNC:5360] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0044089|GO:0007623|GO:0071704|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0007507|GO:0047485|GO:0008284|GO:0042127|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0008022|GO:0070849|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0030324|GO:0045596|GO:0048513|GO:0030279|GO:0016358|GO:0034641|GO:0046483|GO:0051128|GO:0007420|GO:0022607|GO:0051098|GO:0043231|GO:0010243|GO:0005737|GO:0032970|GO:0060322|GO:0071559|GO:0006928|GO:0009887|GO:0032403|GO:1990089|GO:0031589|GO:0009966|GO:0046983|GO:0050673|GO:0009890|GO:0030323|GO:0060548|GO:0032231|GO:0044236|GO:0010646|GO:0006139|GO:0001525|GO:0008104|GO:0007154|GO:0044092|GO:0016477|GO:0007165|GO:0032233|GO:0043621|GO:0030278|GO:0031647|GO:0001503|GO:0008134|GO:0008219|GO:0030030|GO:0048869|GO:0030029|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0005794|GO:0006996|GO:0051090|GO:0009636|GO:0051017|GO:0050768|GO:0000165|GO:0060425|GO:0050679|GO:0032268|GO:0000902|GO:0031175|GO:0005813|GO:0060426|GO:2000171|GO:0031344|GO:0044259|GO:0010468|GO:0090132|GO:0071773|GO:0034645|GO:0051101|GO:0045668|GO:0007166|GO:0032956|GO:0051100|GO:0001944|GO:0043412|GO:1990090|GO:0007010|GO:0072358|GO:0050773|GO:0007417|GO:0010629|GO:0043069|GO:0002064|GO:0048813|GO:0051252|GO:0060541|GO:0005815|GO:0010721|GO:0045667|GO:1901652|GO:0000904|GO:0071417|GO:0010628|GO:0001667|GO:0071869|GO:0036211|GO:0071560|GO:0030856|GO:0001649|GO:0071364|GO:0031345|GO:0031981|GO:0045765|GO:0071867|GO:0070848|GO:0005654|GO:0022604|GO:0043433|GO:0050678|GO:0030036|GO:0034613|GO:0046677|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:1901342|GO:0035556|GO:0060359|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0070628|GO:0007399|GO:0071310|GO:0031648|GO:0051246|GO:0009059|GO:0030154|GO:0048858|GO:1902531|GO:0016070|GO:0072359|GO:0005856|GO:0030857|GO:0005634|GO:0042803|GO:0043067|GO:0036164|GO:0051960|GO:0043393|GO:0010638|GO:0048666|GO:0030182|GO:0003158|GO:0010975|GO:0001885|GO:2000677|GO:0071242|GO:0043496|GO:0030855|GO:1901653|GO:0043408|GO:0010769|GO:0045892|GO:0032774|GO:2001141|GO:0071363|GO:0016310|GO:1902679|GO:0071407|GO:0007179|GO:0003382|GO:0030509|GO:0051493|GO:0007167|GO:0015630|GO:0048814|GO:0010631|GO:0042981|GO:0043066|GO:0050774|GO:0045665|GO:0022008|GO:0048667|GO:0006464|GO:0045601|GO:0007015|GO:0050767|GO:0051495|GO:0048812|GO:0032091|GO:0010621|GO:0010977|GO:0045602|GO:0071870|GO:0006351|GO:0006915|GO:0006355|GO:0032963|GO:0043392|GO:0090074|GO:0001886|GO:0045446|GO:0006366|GO:1903507|GO:0006357|GO:0006468|GO:0048699|GO:1903506|GO:0042325|GO:0001932|GO:1903351|GO:0007178|GO:0000122|GO:2000678|GO:0061572|GO:0043542|GO:0045664|GO:1903025|GO:1903026|GO:0043534 locomotion|developmental process|signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|circadian rhythm|organic substance metabolic process|cellular metabolic process|cellular localization|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|heart development|protein N-terminus binding|positive regulation of cell proliferation|regulation of cell proliferation|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|protein C-terminus binding|response to epidermal growth factor|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|lung development|negative regulation of cell differentiation|animal organ development|negative regulation of ossification|dendrite development|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|cellular component assembly|regulation of binding|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|head development|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|protein complex binding|response to nerve growth factor|cell-substrate adhesion|regulation of signal transduction|protein dimerization activity|epithelial cell proliferation|negative regulation of biosynthetic process|respiratory tube development|negative regulation of cell death|regulation of actin filament bundle assembly|multicellular organism metabolic process|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|protein localization|cell communication|negative regulation of molecular function|cell migration|signal transduction|positive regulation of actin filament bundle assembly|protein self-association|regulation of ossification|regulation of protein stability|ossification|transcription factor binding|cell death|cell projection organization|cellular developmental process|actin filament-based process|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|response to toxic substance|actin filament bundle assembly|negative regulation of neurogenesis|MAPK cascade|lung morphogenesis|positive regulation of epithelial cell proliferation|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|centrosome|lung vasculature development|negative regulation of dendrite development|regulation of cell projection organization|multicellular organismal macromolecule metabolic process|regulation of gene expression|epithelium migration|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|regulation of DNA binding|negative regulation of osteoblast differentiation|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|negative regulation of binding|vasculature development|macromolecule modification|cellular response to nerve growth factor stimulus|cytoskeleton organization|cardiovascular system development|regulation of dendrite development|central nervous system development|negative regulation of gene expression|negative regulation of programmed cell death|epithelial cell development|dendrite morphogenesis|regulation of RNA metabolic process|respiratory system development|microtubule organizing center|negative regulation of cell development|regulation of osteoblast differentiation|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of gene expression|ameboidal-type cell migration|response to catecholamine|protein modification process|cellular response to transforming growth factor beta stimulus|regulation of epithelial cell differentiation|osteoblast differentiation|cellular response to epidermal growth factor stimulus|negative regulation of cell projection organization|nuclear lumen|regulation of angiogenesis|response to monoamine|response to growth factor|nucleoplasm|regulation of cell morphogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of epithelial cell proliferation|actin cytoskeleton organization|cellular protein localization|response to antibiotic|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|response to ammonium ion|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|proteasome binding|nervous system development|cellular response to organic substance|protein destabilization|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|cytoskeleton|negative regulation of epithelial cell differentiation|nucleus|protein homodimerization activity|regulation of programmed cell death|cell-abiotic substrate adhesion|regulation of nervous system development|regulation of protein binding|positive regulation of organelle organization|neuron development|neuron differentiation|endothelium development|regulation of neuron projection development|endothelial cell development|regulation of transcription regulatory region DNA binding|cellular response to ammonium ion|regulation of protein homodimerization activity|epithelial cell differentiation|cellular response to peptide|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|phosphorylation|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|transforming growth factor beta receptor signaling pathway|epithelial cell morphogenesis|BMP signaling pathway|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|regulation of dendrite morphogenesis|epithelial cell migration|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of dendrite morphogenesis|negative regulation of neuron differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of endothelial cell differentiation|actin filament organization|regulation of neurogenesis|positive regulation of cytoskeleton organization|neuron projection morphogenesis|negative regulation of protein binding|negative regulation of transcription by transcription factor localization|negative regulation of neuron projection development|negative regulation of endothelial cell differentiation|cellular response to catecholamine stimulus|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|collagen metabolic process|negative regulation of DNA binding|negative regulation of protein homodimerization activity|endothelial cell morphogenesis|endothelial cell differentiation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to dopamine|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|actin filament bundle organization|endothelial cell migration|regulation of neuron differentiation|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|blood vessel endothelial cell migration K04680 DNA-binding protein inhibitor ID1[-] hsa04015|hsa04390|hsa04550|hsa04350 Rap1 signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human) 20:31605283-31606515 331 357 467 1386 1547 2467 10.5136518372247 10.3056117049329 13.3738584087998 39.4445048384907 40.3165900912684 73.4384617068691 11.3977073169858 51.0665188788761 -2.16363406510055 2.34463162124353e-16 1.24549168008193e-14 DOWN ENSG00000196284 SUPT3H SPT3 homolog, SAGA and STAGA complex component [Source:HGNC Symbol;Acc:HGNC:11466] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0000989|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0050688|GO:0016570|GO:0003676|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0098542|GO:0043231|GO:0016746|GO:0005667|GO:0009615|GO:0046983|GO:0006139|GO:0000422|GO:0016236|GO:0051607|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0003713|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:1903008|GO:0098792|GO:0016578|GO:0000423|GO:0044798|GO:0043412|GO:0007005|GO:0046982|GO:0051252|GO:0006325|GO:0016573|GO:0010628|GO:0036211|GO:0031981|GO:1990234|GO:0006508|GO:0005654|GO:0016747|GO:0044267|GO:0010467|GO:0031328|GO:0000123|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0050691|GO:0045893|GO:0032774|GO:2001141|GO:0043966|GO:0002230|GO:0016407|GO:0070646|GO:0016410|GO:0016568|GO:0090575|GO:0070461|GO:0006464|GO:0098779|GO:0016591|GO:0006351|GO:0006355|GO:0006366|GO:0033276|GO:0006357|GO:1903506|GO:0016579|GO:0000124|GO:0018193|GO:0008080|GO:0030914|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402 macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|transcription factor activity, transcription factor binding|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|regulation of immune system process|protein binding|protein complex|transferase activity|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of defense response to virus|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|defense response to other organism|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|transcription factor complex|response to virus|protein dimerization activity|nucleobase-containing compound metabolic process|mitophagy|macroautophagy|defense response to virus|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|organelle disassembly|xenophagy|histone deubiquitination|macromitophagy|nuclear transcription factor complex|macromolecule modification|mitochondrion organization|protein heterodimerization activity|regulation of RNA metabolic process|chromatin organization|histone acetylation|positive regulation of gene expression|protein modification process|nuclear lumen|transferase complex|proteolysis|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|histone acetyltransferase complex|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of defense response to virus by host|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|histone H3 acetylation|positive regulation of defense response to virus by host|acetyltransferase activity|protein modification by small protein removal|N-acyltransferase activity|chromatin modification|RNA polymerase II transcription factor complex|SAGA-type complex|cellular protein modification process|mitophagy in response to mitochondrial depolarization|DNA-directed RNA polymerase II, holoenzyme|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription factor TFTC complex|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|protein deubiquitination|SAGA complex|peptidyl-amino acid modification|N-acetyltransferase activity|STAGA complex|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity K11313 transcription initiation protein SPT3[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 6:44809317-45377953 2 3 8 76 71 53 0.0181834352051838 0.0247933587268738 0.0655815444696283 0.619119851347468 0.529651336333174 0.451615373460343 0.036186112800562 0.533462187046995 -3.88187796996195 2.37092424482435e-16 1.25722153472444e-14 DOWN ENSG00000162415 ZSWIM5 zinc finger, SWIM-type containing 5 [Source:HGNC Symbol;Acc:HGNC:29299] GO:0005576|GO:0005488|GO:0043167|GO:0005615|GO:0043169|GO:0046872|GO:0046914|GO:0008270 extracellular region|binding|ion binding|extracellular space|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 1:45016399-45306209 2 0 2 39 43 45 0.0227842045250975 0 0.0205437435969443 0.398092619479543 0.401935010548788 0.480465634683415 0.0144426493740139 0.426831088237249 -4.88525793763294 2.51411336933988e-16 1.3307861795793e-14 DOWN ENSG00000122417 ODF2L outer dense fiber of sperm tails 2-like [Source:HGNC Symbol;Acc:HGNC:29225] GO:0005623|GO:0043229|GO:0005622|GO:0005813|GO:0005815|GO:0005856|GO:0015630 cell|intracellular organelle|intracellular|centrosome|microtubule organizing center|cytoskeleton|microtubule cytoskeleton - - - - 1:86346824-86396342 158 133 218 697 995 642 0.559437032405709 0.427982861206032 0.695929602238205 2.21117967208833 2.89057850574323 2.13038381246999 0.561116498616649 2.41071399676718 -2.10308826368759 2.60951992788777e-16 1.37884261817985e-14 DOWN ENSG00000105643 ARRDC2 arrestin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25225] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0031982|GO:0005737|GO:0007154|GO:0007165|GO:0031410 signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|vesicle|cytoplasm|cell communication|signal transduction|cytoplasmic vesicle - - - - 19:18001132-18014102 1154 1237 1131 423 421 416 8.86322568037673 8.63447165535098 7.83182133335521 2.91087632341112 2.65299030700397 2.99438929401742 8.44317288969431 2.85275197481084 1.56543093532155 2.95630959280806e-16 1.55932273116063e-14 UP ENSG00000165895 ARHGAP42 Rho GTPase activating protein 42 [Source:HGNC Symbol;Acc:HGNC:26545] GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0009893|GO:0030234|GO:0005515|GO:0019222|GO:0008047|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005096|GO:0051345|GO:0030695|GO:0043087|GO:0043547 signaling|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|positive regulation of metabolic process|enzyme regulator activity|protein binding|regulation of metabolic process|enzyme activator activity|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|regulation of GTPase activity|positive regulation of GTPase activity - - - - 11:100687653-100991937 133 204 252 741 829 837 0.935839507437958 1.30454686403364 1.59869378424842 4.67160458425041 4.78600083018592 5.51956132890081 1.27969338524001 4.99238891444571 -1.96393214500083 2.99881064764016e-16 1.57895049514373e-14 DOWN ENSG00000149548 CCDC15 coiled-coil domain containing 15 [Source:HGNC Symbol;Acc:HGNC:25798] GO:0005623|GO:0043229|GO:0005622|GO:0005813|GO:0005815|GO:0005856|GO:0015630 cell|intracellular organelle|intracellular|centrosome|microtubule organizing center|cytoskeleton|microtubule cytoskeleton - - - - 11:124954121-125041489 11 15 15 108 130 90 0.118486724974001 0.14684634625307 0.145673428624004 1.04231393462616 1.14892108884202 0.908556839995287 0.137002166617025 1.03326395448782 -2.91493823386075 3.11241288568837e-16 1.63587982903769e-14 DOWN ENSG00000251022 THAP9-AS1 THAP9 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44172] - - - - - - 4:82893009-82900960 1499 1138 1188 398 415 377 11.4718757221673 7.91507859619307 8.19716434813775 2.7290647842436 2.60584612420721 2.70398131138892 9.19470622216604 2.67963073994658 1.77876927290523 3.14332215229634e-16 1.64922213593418e-14 UP ENSG00000141627 DYM dymeclin [Source:HGNC Symbol;Acc:HGNC:21317] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0007275|GO:0048513|GO:0043231|GO:0019899|GO:0005737|GO:0060348|GO:0010256|GO:0005794|GO:0006996|GO:0007030|GO:0001501 developmental process|cell|membrane|cellular process|binding|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|anatomical structure development|multicellular organism development|animal organ development|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|bone development|endomembrane system organization|Golgi apparatus|organelle organization|Golgi organization|skeletal system development - - - - 18:49041474-49461347 56 57 163 612 665 784 0.340784438054365 0.315244893596424 0.894315391248493 3.33687194005006 3.32031706094722 4.47131645164473 0.516781574299761 3.70950181754734 -2.84359891014794 3.16975046092685e-16 1.66017070632474e-14 DOWN ENSG00000185104 FAF1 Fas (TNFRSF6) associated factor 1 [Source:HGNC Symbol;Acc:HGNC:3578] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0044089|GO:0042175|GO:0071704|GO:0009056|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:1903828|GO:0023057|GO:0031224|GO:0030234|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:1900181|GO:0032182|GO:0006810|GO:0051130|GO:0010941|GO:0098797|GO:0030155|GO:0051128|GO:0022607|GO:0010942|GO:0043231|GO:0019899|GO:0051651|GO:0005737|GO:0032880|GO:0034098|GO:0005635|GO:0009966|GO:0045184|GO:0019904|GO:0032387|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0009968|GO:0051649|GO:0008134|GO:0008219|GO:0090317|GO:0050790|GO:0031072|GO:0019207|GO:0016021|GO:0009967|GO:0019538|GO:0031334|GO:0043254|GO:0051224|GO:0031323|GO:2001235|GO:0032268|GO:0005829|GO:0042308|GO:0007166|GO:0043412|GO:0072594|GO:0030163|GO:0019887|GO:0043130|GO:0032386|GO:0051223|GO:0015031|GO:0044265|GO:0036211|GO:0070201|GO:0046907|GO:0042886|GO:0032507|GO:0048471|GO:0006508|GO:0051059|GO:0006461|GO:0034613|GO:0019900|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0042176|GO:0017038|GO:0031503|GO:1902532|GO:0051246|GO:0043068|GO:1903827|GO:1902531|GO:0031264|GO:0005634|GO:0043067|GO:0006606|GO:0097190|GO:0044389|GO:0031625|GO:0051220|GO:1904589|GO:0044257|GO:0043124|GO:0033365|GO:0033157|GO:0043122|GO:0043065|GO:0010498|GO:0051169|GO:2001236|GO:0016310|GO:0015833|GO:0006605|GO:2001238|GO:0031265|GO:0016482|GO:0006886|GO:0051603|GO:0007249|GO:0042981|GO:0042992|GO:0042306|GO:0042345|GO:1900180|GO:0019901|GO:0006464|GO:0097191|GO:0042991|GO:0043549|GO:0006915|GO:1903533|GO:0006913|GO:0045859|GO:1902043|GO:0019941|GO:0006468|GO:0042325|GO:0001932|GO:0042990|GO:0042994|GO:0042347|GO:0007253|GO:0008625|GO:0034504|GO:0046822|GO:0043161|GO:1902041|GO:0006511|GO:0051170 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|negative regulation of cellular protein localization|negative regulation of signaling|intrinsic component of membrane|enzyme regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|negative regulation of protein localization to nucleus|ubiquitin-like protein binding|transport|positive regulation of cellular component organization|regulation of cell death|plasma membrane protein complex|regulation of cell adhesion|regulation of cellular component organization|cellular component assembly|positive regulation of cell death|intracellular membrane-bounded organelle|enzyme binding|maintenance of location in cell|cytoplasm|regulation of protein localization|VCP-NPL4-UFD1 AAA ATPase complex|nuclear envelope|regulation of signal transduction|establishment of protein localization|protein domain specific binding|negative regulation of intracellular transport|regulation of cell communication|protein localization|cell communication|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|establishment of localization in cell|transcription factor binding|cell death|negative regulation of intracellular protein transport|regulation of catalytic activity|heat shock protein binding|kinase regulator activity|integral component of membrane|positive regulation of signal transduction|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|negative regulation of protein transport|regulation of cellular metabolic process|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cytosol|negative regulation of protein import into nucleus|cell surface receptor signaling pathway|macromolecule modification|establishment of protein localization to organelle|protein catabolic process|protein kinase regulator activity|ubiquitin binding|regulation of intracellular transport|regulation of protein transport|protein transport|cellular macromolecule catabolic process|protein modification process|regulation of establishment of protein localization|intracellular transport|amide transport|maintenance of protein location in cell|perinuclear region of cytoplasm|proteolysis|NF-kappaB binding|protein complex assembly|cellular protein localization|kinase binding|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|protein import|protein complex localization|negative regulation of intracellular signal transduction|regulation of protein metabolic process|positive regulation of programmed cell death|regulation of cellular protein localization|regulation of intracellular signal transduction|death-inducing signaling complex|nucleus|regulation of programmed cell death|protein import into nucleus|apoptotic signaling pathway|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cytoplasmic sequestering of protein|regulation of protein import|cellular protein catabolic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|protein localization to organelle|regulation of intracellular protein transport|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of apoptotic process|proteasomal protein catabolic process|nuclear transport|regulation of extrinsic apoptotic signaling pathway|phosphorylation|peptide transport|protein targeting|positive regulation of extrinsic apoptotic signaling pathway|CD95 death-inducing signaling complex|cytosolic transport|intracellular protein transport|proteolysis involved in cellular protein catabolic process|I-kappaB kinase/NF-kappaB signaling|regulation of apoptotic process|negative regulation of transcription factor import into nucleus|regulation of protein import into nucleus|regulation of NF-kappaB import into nucleus|regulation of protein localization to nucleus|protein kinase binding|cellular protein modification process|extrinsic apoptotic signaling pathway|transcription factor import into nucleus|regulation of kinase activity|apoptotic process|regulation of protein targeting|nucleocytoplasmic transport|regulation of protein kinase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|modification-dependent protein catabolic process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|regulation of transcription factor import into nucleus|cytoplasmic sequestering of transcription factor|negative regulation of NF-kappaB import into nucleus|cytoplasmic sequestering of NF-kappaB|extrinsic apoptotic signaling pathway via death domain receptors|protein localization to nucleus|regulation of nucleocytoplasmic transport|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of extrinsic apoptotic signaling pathway via death domain receptors|ubiquitin-dependent protein catabolic process|nuclear import - - - - 1:50437028-50960263 340 444 572 1672 1960 1428 2.98541929475017 3.54315081584193 4.52831569825817 13.1540708712454 14.120508133749 11.7512365603525 3.68562860295009 13.008605188449 -1.81948367688843 3.32103069723003e-16 1.73635815122776e-14 DOWN ENSG00000203697 CAPN8 calpain 8 [Source:HGNC Symbol;Acc:HGNC:1485] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0043227|GO:0016787|GO:0005622|GO:0012505|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0007586|GO:0019538|GO:0005794|GO:0046872|GO:0006508|GO:0005509|GO:0004175|GO:0008234|GO:0004197|GO:0004198 cell|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|membrane-bounded organelle|hydrolase activity|intracellular|endomembrane system|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|digestion|protein metabolic process|Golgi apparatus|metal ion binding|proteolysis|calcium ion binding|endopeptidase activity|cysteine-type peptidase activity|cysteine-type endopeptidase activity|calcium-dependent cysteine-type endopeptidase activity - - - - 1:223538007-223665734 511 592 1373 4553 4428 6495 5.0789012674876 5.34749805818812 12.3036339150321 40.5456383321334 36.1097397904172 60.5002111248893 7.57667774690261 45.7185297491466 -2.59314171577369 3.34503391580484e-16 1.74585039374891e-14 DOWN ENSG00000134882 UBAC2 UBA domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20486] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0051051|GO:0051641|GO:0043227|GO:1903828|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:0006810|GO:0033554|GO:0043231|GO:1903573|GO:0005737|GO:0032880|GO:0045184|GO:0032387|GO:0008104|GO:0005783|GO:0051649|GO:0090317|GO:0016021|GO:0019538|GO:0010033|GO:0051224|GO:0036503|GO:0030163|GO:0030970|GO:0032386|GO:0051223|GO:0015031|GO:0070201|GO:0046907|GO:0034613|GO:0042176|GO:1904292|GO:1904293|GO:0051246|GO:1903827|GO:0042177|GO:0034976|GO:0033365|GO:0033157|GO:0032527|GO:0016482|GO:0006886|GO:1904152|GO:1904153|GO:0070972|GO:0070861 cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|negative regulation of transport|cellular localization|membrane-bounded organelle|negative regulation of cellular protein localization|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|transport|cellular response to stress|intracellular membrane-bounded organelle|negative regulation of response to endoplasmic reticulum stress|cytoplasm|regulation of protein localization|establishment of protein localization|negative regulation of intracellular transport|protein localization|endoplasmic reticulum|establishment of localization in cell|negative regulation of intracellular protein transport|integral component of membrane|protein metabolic process|response to organic substance|negative regulation of protein transport|ERAD pathway|protein catabolic process|retrograde protein transport, ER to cytosol|regulation of intracellular transport|regulation of protein transport|protein transport|regulation of establishment of protein localization|intracellular transport|cellular protein localization|regulation of protein catabolic process|regulation of ERAD pathway|negative regulation of ERAD pathway|regulation of protein metabolic process|regulation of cellular protein localization|negative regulation of protein catabolic process|response to endoplasmic reticulum stress|protein localization to organelle|regulation of intracellular protein transport|protein exit from endoplasmic reticulum|cytosolic transport|intracellular protein transport|regulation of retrograde protein transport, ER to cytosol|negative regulation of retrograde protein transport, ER to cytosol|protein localization to endoplasmic reticulum|regulation of protein exit from endoplasmic reticulum - - - - 13:99200774-99386434 221 230 407 1073 1138 1269 2.11769346403521 2.00299098864616 3.51625119275916 9.2123243904912 8.94708959748941 11.3962596040212 2.54564521514684 9.85189119733394 -1.95236932922161 3.42886943332786e-16 1.78648286322111e-14 DOWN ENSG00000167220 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25364] GO:0005576|GO:0005488|GO:1903561|GO:0043167|GO:0043227|GO:0005515|GO:0031982|GO:0043169|GO:0019899|GO:0070062|GO:0046872 extracellular region|binding|extracellular vesicle|ion binding|membrane-bounded organelle|protein binding|vesicle|cation binding|enzyme binding|extracellular exosome|metal ion binding - - - - 18:47107403-47150520 38 42 79 352 349 265 0.281084169604525 0.282345151868756 0.526860397909627 2.33287573973243 2.11809560018812 1.83707085060731 0.363429906460969 2.09601406350929 -2.52789934867271 3.4796894709394e-16 1.8098022554952e-14 DOWN ENSG00000232931 LINC00342 long intergenic non-protein coding RNA 342 [Source:HGNC Symbol;Acc:HGNC:42470] - - - - - - 2:95807118-95816215 11 7 12 105 89 168 0.275922809540519 0.159589198301899 0.271395965943462 2.35984578367925 1.8317087389177 3.94943814129953 0.23563599126196 2.71366422129883 -3.52561039838734 3.50256037316308e-16 1.81852934574627e-14 DOWN ENSG00000133884 DPF2 D4, zinc and double PHD fingers family 2 [Source:HGNC Symbol;Acc:HGNC:9964] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0000790|GO:0007154|GO:0007165|GO:0008219|GO:0044249|GO:0031323|GO:0003677|GO:0005813|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0005815|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0012501|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0097190|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0015630|GO:0046914|GO:0006351|GO:0006915|GO:0006355|GO:1903506|GO:0044212|GO:0008270|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|nuclear chromatin|cell communication|signal transduction|cell death|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|centrosome|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|microtubule organizing center|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|programmed cell death|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|apoptotic signaling pathway|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|microtubule cytoskeleton|transition metal ion binding|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|zinc ion binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 11:65333754-65353249 3002 2871 2774 1042 1084 877 14.0611858596065 12.2214976322086 11.7147206067061 4.3729707508211 4.16589829370191 3.84981674204083 12.6658013661737 4.12956192885461 1.61687770809488 3.7095742015888e-16 1.92266715649708e-14 UP ENSG00000150893 FREM2 FRAS1 related extracellular matrix protein 2 [Source:HGNC Symbol;Acc:HGNC:25396] GO:0032502|GO:0031012|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0005604|GO:1903561|GO:0005578|GO:0043167|GO:0009653|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005886|GO:0048856|GO:0007507|GO:0009888|GO:0048839|GO:0007275|GO:0048513|GO:0031982|GO:0098609|GO:0043169|GO:0007423|GO:0048729|GO:0007154|GO:0070062|GO:0016021|GO:0098742|GO:0046872|GO:0002009|GO:0072358|GO:0043583|GO:0060429|GO:0072359|GO:0005509|GO:0007156 developmental process|extracellular matrix|cell|membrane|cellular process|extracellular region|binding|basement membrane|extracellular vesicle|proteinaceous extracellular matrix|ion binding|anatomical structure morphogenesis|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|plasma membrane|anatomical structure development|heart development|tissue development|inner ear development|multicellular organism development|animal organ development|vesicle|cell-cell adhesion|cation binding|sensory organ development|tissue morphogenesis|cell communication|extracellular exosome|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|metal ion binding|morphogenesis of an epithelium|cardiovascular system development|ear development|epithelium development|circulatory system development|calcium ion binding|homophilic cell adhesion via plasma membrane adhesion molecules - - - - 13:38687129-38887131 20 18 61 284 317 474 0.0872056660242988 0.0713290659818314 0.239805279496327 1.10951026791793 1.134073877793 1.936965557977 0.132780003834152 1.39351656789598 -3.39162035139127 3.86745951014039e-16 2.0010248910872e-14 DOWN ENSG00000148481 FAM188A family with sequence similarity 188 member A [Source:HGNC Symbol;Acc:HGNC:23578] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0005635|GO:0008219|GO:0031965|GO:0031981|GO:0005654|GO:0012501|GO:0005634|GO:0006915 cell|membrane|cellular process|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|nuclear envelope|cell death|nuclear membrane|nuclear lumen|nucleoplasm|programmed cell death|nucleus|apoptotic process - - - - 10:15778170-15860520 35 19 39 189 219 226 0.490252295962203 0.241879042407958 0.492536763107913 2.37199294540861 2.51690761072742 2.96682819952973 0.408222700492691 2.61857625188859 -2.68135430084104 3.89670879050022e-16 2.01267031542549e-14 DOWN ENSG00000068489 PRR11 proline rich 11 [Source:HGNC Symbol;Acc:HGNC:25619] GO:0005623|GO:0016020|GO:0009987|GO:0050794|GO:0043229|GO:0043227|GO:0005622|GO:0051726|GO:0007049|GO:0043231|GO:0005737|GO:0005634 cell|membrane|cellular process|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intracellular|regulation of cell cycle|cell cycle|intracellular membrane-bounded organelle|cytoplasm|nucleus - - - - 17:59155499-59204705 223 232 267 838 989 776 2.58723085752881 2.44622832251011 2.79289913380732 8.71106432255047 9.41442879879925 8.43762931837727 2.60878610461541 8.85437414657566 -1.76301167473848 3.957735407272e-16 2.04066032553883e-14 DOWN ENSG00000158062 UBXN11 UBX domain protein 11 [Source:HGNC Symbol;Acc:HGNC:30600] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0005622|GO:0005515|GO:0032182|GO:0005737|GO:0019538|GO:0030163|GO:0043130|GO:0044265|GO:0006508|GO:0044267|GO:0005856|GO:0044257|GO:0010498|GO:0051603|GO:0019941|GO:0043161|GO:0006511 cell|cellular process|metabolic process|binding|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|intracellular|protein binding|ubiquitin-like protein binding|cytoplasm|protein metabolic process|protein catabolic process|ubiquitin binding|cellular macromolecule catabolic process|proteolysis|cellular protein metabolic process|cytoskeleton|cellular protein catabolic process|proteasomal protein catabolic process|proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process - - - - 1:26281328-26318363 103 110 110 505 504 404 0.982327277724139 0.953431741768592 0.945852160520058 4.31525854334 3.94381210324863 3.61100524964506 0.960537060004263 3.95669196541123 -2.04238157065865 4.05605994600555e-16 2.08775195910431e-14 DOWN ENSG00000082438 COBLL1 cordon-bleu WH2 repeat protein like 1 [Source:HGNC Symbol;Acc:HGNC:23571] GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0016043|GO:0043227|GO:0005515|GO:0031982|GO:0022607|GO:0070062|GO:0008092|GO:0030029|GO:0006996|GO:0007010|GO:0003779|GO:0006461|GO:0030036|GO:0003785|GO:0034622|GO:0043623|GO:0007015|GO:0051258|GO:0051639|GO:0008154|GO:0030041 cellular process|extracellular region|binding|extracellular vesicle|cellular component organization|membrane-bounded organelle|protein binding|vesicle|cellular component assembly|extracellular exosome|cytoskeletal protein binding|actin filament-based process|organelle organization|cytoskeleton organization|actin binding|protein complex assembly|actin cytoskeleton organization|actin monomer binding|cellular macromolecular complex assembly|cellular protein complex assembly|actin filament organization|protein polymerization|actin filament network formation|actin polymerization or depolymerization|actin filament polymerization - - - - 2:164653624-164843679 21 22 16 129 141 143 0.0433799852042639 0.0413012687110013 0.0297993468037442 0.238752524656216 0.238972365585468 0.276838581175403 0.0381602002396698 0.251521157139029 -2.72053911314239 4.08666778628217e-16 2.09988606009756e-14 DOWN ENSG00000204520 MICA MHC class I polypeptide-related sequence A [Source:HGNC Symbol;Acc:HGNC:7090] GO:0002376|GO:0016020|GO:0050896|GO:0005488|GO:0006955|GO:0031224|GO:0005515|GO:0016021 immune system process|membrane|response to stimulus|binding|immune response|intrinsic component of membrane|protein binding|integral component of membrane K07985 MHC class I-related protein[-] hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) 6:31399784-31415315 450 500 547 148 175 116 11.7070838792019 11.8218874177457 12.8303395878731 3.44981448869118 3.73545631706204 2.82829485043065 12.1197702949402 3.33785521872796 1.8603690722895 4.38179481671553e-16 2.24766499069116e-14 UP ENSG00000167969 ECI1 enoyl-CoA delta isomerase 1 [Source:HGNC Symbol;Acc:HGNC:2703] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016853|GO:0005622|GO:0005515|GO:0031090|GO:0042802|GO:0044255|GO:0019866|GO:0006082|GO:0044281|GO:0031982|GO:0043231|GO:0005737|GO:0031966|GO:0016860|GO:0006629|GO:0070062|GO:0055114|GO:0005740|GO:0016042|GO:0044242|GO:0006631|GO:0034440|GO:0005743|GO:0016863|GO:0005759|GO:0005739|GO:0030258|GO:0004165|GO:0046395|GO:0019752|GO:0009062|GO:0019395|GO:0006635|GO:0032787 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|isomerase activity|intracellular|protein binding|organelle membrane|identical protein binding|cellular lipid metabolic process|organelle inner membrane|organic acid metabolic process|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|intramolecular oxidoreductase activity|lipid metabolic process|extracellular exosome|oxidation-reduction process|mitochondrial envelope|lipid catabolic process|cellular lipid catabolic process|fatty acid metabolic process|lipid oxidation|mitochondrial inner membrane|intramolecular oxidoreductase activity, transposing C=C bonds|mitochondrial matrix|mitochondrion|lipid modification|dodecenoyl-CoA delta-isomerase activity|carboxylic acid catabolic process|carboxylic acid metabolic process|fatty acid catabolic process|fatty acid oxidation|fatty acid beta-oxidation|monocarboxylic acid metabolic process K13238 3,2-trans-enoyl-CoA isomerase, mitochondrial[5.3.3.8] hsa00071 Fatty acid degradation - Homo sapiens (human) 16:2239395-2252300 205 249 286 816 1095 819 2.93841461891333 3.2436815891279 3.69605990528549 10.4796442827663 12.8777712113818 11.0019991062087 3.29271870444224 11.4531382001189 -1.79839178251423 4.770042763587e-16 2.44262189818399e-14 DOWN ENSG00000002822 MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) [Source:HGNC Symbol;Acc:HGNC:6762] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0007155|GO:0043227|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0019222|GO:0060341|GO:0051726|GO:0042127|GO:0007049|GO:0016337|GO:0051640|GO:0070661|GO:0022402|GO:0007275|GO:0048513|GO:0070489|GO:0051302|GO:0000776|GO:0030155|GO:0051128|GO:0098609|GO:0045786|GO:0043231|GO:0005737|GO:0005635|GO:0051656|GO:0001775|GO:0051782|GO:0007162|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0051983|GO:0051649|GO:0002695|GO:0008285|GO:0007059|GO:0051301|GO:0019538|GO:0031324|GO:0031323|GO:0048732|GO:0006996|GO:0051276|GO:0051249|GO:0032268|GO:0005829|GO:0005813|GO:0000819|GO:0048538|GO:0000075|GO:0032943|GO:1903047|GO:0030163|GO:0051304|GO:0005815|GO:0034109|GO:0044770|GO:0044265|GO:0032269|GO:0000278|GO:0090235|GO:0051250|GO:0022408|GO:0022407|GO:0007346|GO:0010564|GO:0007159|GO:0045930|GO:0006508|GO:0070664|GO:0005694|GO:0042110|GO:0035556|GO:0033043|GO:0044267|GO:0042176|GO:0007067|GO:0051246|GO:0046651|GO:0042177|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0000777|GO:0005643|GO:0051303|GO:0010948|GO:1903038|GO:0015629|GO:0044257|GO:0031577|GO:0042098|GO:0050863|GO:0072686|GO:2001251|GO:0010498|GO:0007093|GO:0007088|GO:0000793|GO:1903363|GO:0044772|GO:0050868|GO:0030162|GO:0007094|GO:0071174|GO:0033044|GO:0070486|GO:1901990|GO:0051603|GO:0045839|GO:0015630|GO:0000070|GO:0051310|GO:0051306|GO:0045861|GO:1901987|GO:0007091|GO:0034111|GO:0032945|GO:0007264|GO:0050672|GO:1901991|GO:0000775|GO:0030071|GO:0071173|GO:0000779|GO:0010965|GO:0019941|GO:1901799|GO:2000816|GO:0042130|GO:0042129|GO:1903051|GO:0071593|GO:0061136|GO:0043161|GO:0006511|GO:0032434|GO:0032435 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|cell adhesion|membrane-bounded organelle|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|regulation of cell proliferation|cell cycle|single organismal cell-cell adhesion|organelle localization|leukocyte proliferation|cell cycle process|multicellular organism development|animal organ development|T cell aggregation|regulation of cell division|kinetochore|regulation of cell adhesion|regulation of cellular component organization|cell-cell adhesion|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|establishment of organelle localization|cell activation|negative regulation of cell division|negative regulation of cell adhesion|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|regulation of chromosome segregation|establishment of localization in cell|negative regulation of leukocyte activation|negative regulation of cell proliferation|chromosome segregation|cell division|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|organelle organization|chromosome organization|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|centrosome|sister chromatid segregation|thymus development|cell cycle checkpoint|mononuclear cell proliferation|mitotic cell cycle process|protein catabolic process|chromosome separation|microtubule organizing center|homotypic cell-cell adhesion|cell cycle phase transition|cellular macromolecule catabolic process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of metaphase plate congression|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of mitotic cell cycle|regulation of cell cycle process|leukocyte cell-cell adhesion|negative regulation of mitotic cell cycle|proteolysis|negative regulation of leukocyte proliferation|chromosome|T cell activation|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|mitotic nuclear division|regulation of protein metabolic process|lymphocyte proliferation|negative regulation of protein catabolic process|cytoskeleton|spindle pole|nucleus|spindle|condensed chromosome kinetochore|nuclear pore|establishment of chromosome localization|negative regulation of cell cycle process|negative regulation of leukocyte cell-cell adhesion|actin cytoskeleton|cellular protein catabolic process|spindle checkpoint|T cell proliferation|regulation of T cell activation|mitotic spindle|negative regulation of chromosome organization|proteasomal protein catabolic process|mitotic cell cycle checkpoint|regulation of mitotic nuclear division|condensed chromosome|negative regulation of cellular protein catabolic process|mitotic cell cycle phase transition|negative regulation of T cell activation|regulation of proteolysis|mitotic spindle assembly checkpoint|mitotic spindle checkpoint|regulation of chromosome organization|leukocyte aggregation|regulation of mitotic cell cycle phase transition|proteolysis involved in cellular protein catabolic process|negative regulation of mitotic nuclear division|microtubule cytoskeleton|mitotic sister chromatid segregation|metaphase plate congression|mitotic sister chromatid separation|negative regulation of proteolysis|regulation of cell cycle phase transition|metaphase/anaphase transition of mitotic cell cycle|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|small GTPase mediated signal transduction|negative regulation of lymphocyte proliferation|negative regulation of mitotic cell cycle phase transition|chromosome, centromeric region|regulation of mitotic metaphase/anaphase transition|spindle assembly checkpoint|condensed chromosome, centromeric region|regulation of mitotic sister chromatid separation|modification-dependent protein catabolic process|negative regulation of proteasomal protein catabolic process|negative regulation of mitotic sister chromatid separation|negative regulation of T cell proliferation|regulation of T cell proliferation|negative regulation of proteolysis involved in cellular protein catabolic process|lymphocyte aggregation|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process K06638 mitotic spindle assembly checkpoint protein MAD1[-] hsa05203|hsa04110|hsa04914 Viral carcinogenesis - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human) 7:1815793-2233243 71 86 128 434 478 402 0.510813149170145 0.562317735842146 0.830287877391997 2.79763958262791 2.82162833476813 2.71055572916106 0.634472920801429 2.7766078821857 -2.12969295491166 4.90283882187878e-16 2.50632448952687e-14 DOWN ENSG00000133103 COG6 component of oligomeric golgi complex 6 [Source:HGNC Symbol;Acc:HGNC:18621] GO:0032991|GO:0005623|GO:0016020|GO:0008152|GO:0043229|GO:0071704|GO:0051641|GO:0043227|GO:0005622|GO:0043234|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0005975|GO:0045184|GO:0008104|GO:0051649|GO:0017119|GO:0005794|GO:0016192|GO:0015031|GO:0046907|GO:0070085|GO:0000139|GO:0048193|GO:0006891 macromolecular complex|cell|membrane|metabolic process|intracellular organelle|organic substance metabolic process|cellular localization|membrane-bounded organelle|intracellular|protein complex|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|establishment of protein localization|protein localization|establishment of localization in cell|Golgi transport complex|Golgi apparatus|vesicle-mediated transport|protein transport|intracellular transport|glycosylation|Golgi membrane|Golgi vesicle transport|intra-Golgi vesicle-mediated transport - - - - 13:39655627-39791665 162 215 330 908 950 1159 0.970474871713577 1.17054542442901 1.78236984858448 4.87363572329307 4.66939671850205 6.50701555619752 1.30779671490902 5.35001599933088 -2.03240490147301 5.15493407612685e-16 2.6306906309178e-14 DOWN ENSG00000131558 EXOC4 exocyst complex component 4 [Source:HGNC Symbol;Acc:HGNC:30389] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0043209|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0030427|GO:0071944|GO:0005622|GO:0005515|GO:0035748|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0047485|GO:0009888|GO:0006810|GO:0000145|GO:0005938|GO:0007275|GO:0048513|GO:0032940|GO:0030426|GO:0019899|GO:0005737|GO:0009887|GO:0022406|GO:0043005|GO:0048729|GO:0048598|GO:0045184|GO:0019904|GO:0008104|GO:0001704|GO:0061024|GO:0032584|GO:0019538|GO:0006996|GO:0016192|GO:0005829|GO:0048278|GO:0007498|GO:0030165|GO:0015031|GO:0009790|GO:0006887|GO:0007369|GO:0001707|GO:0060485|GO:0044267|GO:0046903|GO:0005902|GO:0051020|GO:0048332|GO:0006904|GO:0048339|GO:0031267|GO:0048341|GO:0048340|GO:0017016|GO:0017160 developmental process|macromolecular complex|cell|membrane|cellular process|metabolic process|binding|cell projection|myelin sheath|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell periphery|intracellular|protein binding|myelin sheath abaxonal region|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|protein N-terminus binding|tissue development|transport|exocyst|cell cortex|multicellular organism development|animal organ development|secretion by cell|growth cone|enzyme binding|cytoplasm|organ morphogenesis|membrane docking|neuron projection|tissue morphogenesis|embryonic morphogenesis|establishment of protein localization|protein domain specific binding|protein localization|formation of primary germ layer|membrane organization|growth cone membrane|protein metabolic process|organelle organization|vesicle-mediated transport|cytosol|vesicle docking|mesoderm development|PDZ domain binding|protein transport|embryo development|exocytosis|gastrulation|mesoderm formation|mesenchyme development|cellular protein metabolic process|secretion|microvillus|GTPase binding|mesoderm morphogenesis|vesicle docking involved in exocytosis|paraxial mesoderm development|small GTPase binding|paraxial mesoderm formation|paraxial mesoderm morphogenesis|Ras GTPase binding|Ral GTPase binding K06111 exocyst complex component 4[-] hsa04530 Tight junction - Homo sapiens (human) 7:133253073-134066589 169 192 386 1123 1101 1422 0.932491057434128 0.96280514814207 1.92025433597457 5.55181693015005 4.98439983850458 7.35336792052907 1.27185018051692 5.96319489639457 -2.22915675322467 5.27676367421986e-16 2.6882679646785e-14 DOWN ENSG00000197702 PARVA parvin alpha [Source:HGNC Symbol;Acc:HGNC:14652] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0030055|GO:0043229|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0009605|GO:0031252|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0048514|GO:0007507|GO:0016337|GO:0006935|GO:0048468|GO:0001568|GO:0034446|GO:0007275|GO:0060411|GO:0048513|GO:0005924|GO:0005912|GO:0098609|GO:0043231|GO:0005737|GO:0006928|GO:0009887|GO:0031589|GO:0030027|GO:0001525|GO:0007163|GO:0016477|GO:0003151|GO:0003279|GO:0008092|GO:0048869|GO:0030029|GO:0006996|GO:0003205|GO:0000902|GO:0002040|GO:0001944|GO:0007010|GO:0072358|GO:0003148|GO:0030048|GO:0003779|GO:0003007|GO:0000904|GO:0060326|GO:0030036|GO:0034113|GO:0030154|GO:0072359|GO:0005856|GO:0005634|GO:0005925|GO:0015629|GO:0070252|GO:0031532|GO:0014909|GO:0071670 locomotion|developmental process|cell|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|cell-substrate junction|intracellular organelle|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|response to external stimulus|cell leading edge|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|heart development|single organismal cell-cell adhesion|chemotaxis|cell development|blood vessel development|substrate adhesion-dependent cell spreading|multicellular organism development|cardiac septum morphogenesis|animal organ development|cell-substrate adherens junction|adherens junction|cell-cell adhesion|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|organ morphogenesis|cell-substrate adhesion|lamellipodium|angiogenesis|establishment or maintenance of cell polarity|cell migration|outflow tract morphogenesis|cardiac septum development|cytoskeletal protein binding|cellular developmental process|actin filament-based process|organelle organization|cardiac chamber development|cell morphogenesis|sprouting angiogenesis|vasculature development|cytoskeleton organization|cardiovascular system development|outflow tract septum morphogenesis|actin filament-based movement|actin binding|heart morphogenesis|cell morphogenesis involved in differentiation|cell chemotaxis|actin cytoskeleton organization|heterotypic cell-cell adhesion|cell differentiation|circulatory system development|cytoskeleton|nucleus|focal adhesion|actin cytoskeleton|actin-mediated cell contraction|actin cytoskeleton reorganization|smooth muscle cell migration|smooth muscle cell chemotaxis K06275 parvin[-] hsa04510 Focal adhesion - Homo sapiens (human) 11:12377185-12530801 80 75 72 515 540 301 0.628702375252616 0.535671378801031 0.510152899350727 3.62626563979659 3.48190207990766 2.21692567067077 0.558175551134791 3.10836446345834 -2.4773648343907 5.48078573155827e-16 2.78745106013527e-14 DOWN ENSG00000146094 DOK3 docking protein 3 [Source:HGNC Symbol;Acc:HGNC:24583] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0050794|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0005102|GO:0005737|GO:0032403|GO:0007154|GO:0007165|GO:0005158|GO:0035556|GO:0007264|GO:0007265 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|cell periphery|intracellular|protein binding|plasma membrane|receptor binding|cytoplasm|protein complex binding|cell communication|signal transduction|insulin receptor binding|intracellular signal transduction|small GTPase mediated signal transduction|Ras protein signal transduction - - - - 5:177501907-177511274 238 237 183 41 51 41 1.70796217034088 1.54571583822637 1.18404008803964 0.263621667805839 0.300288722443486 0.275750039995785 1.47923936553563 0.279886810081703 2.40194011806249 5.51260473188114e-16 2.79886567458469e-14 UP ENSG00000137942 FNBP1L formin binding protein 1-like [Source:HGNC Symbol;Acc:HGNC:20851] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0050794|GO:0043229|GO:0044089|GO:0051641|GO:0006914|GO:0009653|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0005085|GO:0048856|GO:0048646|GO:0019222|GO:0051640|GO:0006810|GO:0051130|GO:0005938|GO:0031982|GO:0051491|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0006928|GO:0051656|GO:0005086|GO:0043085|GO:0061024|GO:0060491|GO:0070062|GO:0051649|GO:0050790|GO:0030030|GO:0048869|GO:0030029|GO:0010256|GO:0005794|GO:0006996|GO:0016192|GO:0051650|GO:0000902|GO:0031344|GO:0005802|GO:0006900|GO:0016050|GO:0031410|GO:0051345|GO:0030048|GO:0031346|GO:0007009|GO:0016023|GO:0044782|GO:0046907|GO:0030031|GO:0010324|GO:0031988|GO:0070925|GO:0042384|GO:0032990|GO:0051648|GO:0048858|GO:0005856|GO:0051489|GO:0060271|GO:0030050|GO:0043087|GO:0043547|GO:0046847|GO:0097320|GO:0006897|GO:0030705|GO:0006898|GO:0072583 developmental process|cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|cellular localization|autophagy|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|endomembrane system|guanyl-nucleotide exchange factor activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|organelle localization|transport|positive regulation of cellular component organization|cell cortex|vesicle|positive regulation of filopodium assembly|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|establishment of organelle localization|ARF guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|membrane organization|regulation of cell projection assembly|extracellular exosome|establishment of localization in cell|regulation of catalytic activity|cell projection organization|cellular developmental process|actin filament-based process|endomembrane system organization|Golgi apparatus|organelle organization|vesicle-mediated transport|establishment of vesicle localization|cell morphogenesis|regulation of cell projection organization|trans-Golgi network|membrane budding|vesicle organization|cytoplasmic vesicle|positive regulation of hydrolase activity|actin filament-based movement|positive regulation of cell projection organization|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|cilium organization|intracellular transport|cell projection assembly|membrane invagination|membrane-bounded vesicle|organelle assembly|cilium assembly|cell part morphogenesis|vesicle localization|cell projection morphogenesis|cytoskeleton|regulation of filopodium assembly|cilium morphogenesis|vesicle transport along actin filament|regulation of GTPase activity|positive regulation of GTPase activity|filopodium assembly|membrane tubulation|endocytosis|cytoskeleton-dependent intracellular transport|receptor-mediated endocytosis|clathrin-mediated endocytosis - - - - 1:93448131-93554661 471 568 960 2573 2937 2468 3.02140793333498 3.31143995921168 5.55231050660699 14.788560048087 15.4582495499677 14.8375569027455 3.96171946638455 15.0281221669334 -1.92346611895782 5.79174911015335e-16 2.93560064404954e-14 DOWN ENSG00000005436 GCFC2 GC-rich sequence DNA-binding factor 2 [Source:HGNC Symbol;Acc:HGNC:1317] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0000981|GO:0030529|GO:0009890|GO:0006139|GO:0044249|GO:0022613|GO:0031324|GO:0031323|GO:0000982|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0022618|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0001227|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0034622|GO:0001078|GO:0006396|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0071014|GO:1902679|GO:0003690|GO:0005684|GO:0016071|GO:0006351|GO:0000245|GO:0006355|GO:0006366|GO:1903507|GO:0071008|GO:0006357|GO:1903506|GO:0044212|GO:0006397|GO:0008380|GO:0000122|GO:0000375|GO:0000976|GO:0001012|GO:0001159|GO:0000398|GO:0000977|GO:0000987|GO:0000978 macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|intracellular ribonucleoprotein complex|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|ribonucleoprotein complex assembly|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|cellular macromolecular complex assembly|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|RNA processing|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|post-mRNA release spliceosomal complex|negative regulation of RNA biosynthetic process|double-stranded DNA binding|U2-type spliceosomal complex|mRNA metabolic process|transcription, DNA-templated|spliceosomal complex assembly|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|U2-type post-mRNA release spliceosomal complex|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|mRNA processing|RNA splicing|negative regulation of transcription from RNA polymerase II promoter|RNA splicing, via transesterification reactions|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|mRNA splicing, via spliceosome|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 2:75652000-75710989 102 89 90 484 530 369 0.651246026307187 0.516436529442644 0.51808747928484 2.76877938174161 2.77644199212935 2.20800999922336 0.561923345011557 2.58441045769811 -2.20138997478047 5.89951528748726e-16 2.98515473546855e-14 DOWN ENSG00000166352 C11orf74 chromosome 11 open reading frame 74 [Source:HGNC Symbol;Acc:HGNC:25142] - - - - - - 11:36594493-36659290 11 6 15 85 113 91 0.18447186413093 0.0914470868834559 0.226798815972934 1.27719586914434 1.55483564981842 1.43024620996367 0.167572588995773 1.42075924297548 -3.08380401923183 6.35090183749513e-16 3.20811884021285e-14 DOWN ENSG00000167601 AXL AXL receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:905] GO:0040011|GO:0032502|GO:0004871|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0002683|GO:0097159|GO:0004872|GO:0048523|GO:0050794|GO:0045321|GO:0051050|GO:0006950|GO:0044702|GO:0044216|GO:0071704|GO:0043167|GO:0006955|GO:0009986|GO:0042698|GO:0019953|GO:0044237|GO:0038023|GO:0003006|GO:0048870|GO:0023051|GO:0009653|GO:0072341|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0002262|GO:0009607|GO:0009605|GO:0032504|GO:0031224|GO:0005615|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0048609|GO:0016032|GO:0001818|GO:1903706|GO:0050817|GO:0045087|GO:0045595|GO:0060760|GO:0048468|GO:0050867|GO:0006810|GO:0051130|GO:0010941|GO:0034446|GO:0009991|GO:0007275|GO:0060627|GO:0048513|GO:0034101|GO:0044228|GO:0043168|GO:0032940|GO:0006952|GO:0030900|GO:0001618|GO:0005543|GO:0001882|GO:0016772|GO:0031982|GO:0051128|GO:0007420|GO:0001817|GO:0045807|GO:0005887|GO:0045597|GO:0048608|GO:0004888|GO:0001816|GO:0031668|GO:0009611|GO:0060322|GO:0006928|GO:0042592|GO:0043177|GO:0002696|GO:0001775|GO:0031589|GO:0009966|GO:0046983|GO:0007548|GO:0048771|GO:0043657|GO:0060548|GO:0010646|GO:0031226|GO:0009617|GO:0046649|GO:0050865|GO:0001786|GO:0007154|GO:0007276|GO:0016477|GO:0007165|GO:0070062|GO:0008219|GO:0002695|GO:0000166|GO:0048869|GO:0016021|GO:0048806|GO:0009967|GO:0019538|GO:0010033|GO:0050878|GO:0051701|GO:0016192|GO:1902533|GO:0051249|GO:0000902|GO:0006909|GO:0030540|GO:0030168|GO:1901215|GO:0030101|GO:0048232|GO:0007166|GO:0001959|GO:0033993|GO:0035639|GO:0043412|GO:0061458|GO:0030097|GO:0034097|GO:0030098|GO:0007417|GO:0002237|GO:0043069|GO:0046982|GO:0007596|GO:1903556|GO:0001883|GO:0070997|GO:0000904|GO:0048549|GO:0021885|GO:0036211|GO:0001961|GO:0042060|GO:0071219|GO:0001764|GO:0048872|GO:0006954|GO:0032549|GO:0051251|GO:0051250|GO:0007599|GO:0030100|GO:0016301|GO:1901214|GO:0001974|GO:0032689|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0032609|GO:0031406|GO:0007399|GO:0046903|GO:0019058|GO:0071310|GO:0017076|GO:0030154|GO:0048469|GO:1902531|GO:0016773|GO:0032496|GO:0043067|GO:0032649|GO:0060068|GO:0032680|GO:0002521|GO:0051896|GO:0032720|GO:0043491|GO:0007283|GO:0019221|GO:0032816|GO:0043523|GO:0046718|GO:0005524|GO:0030554|GO:0016310|GO:0051897|GO:0045619|GO:0032640|GO:0007167|GO:0001779|GO:0042981|GO:0071345|GO:0016597|GO:0043066|GO:0004672|GO:0043277|GO:0051402|GO:0035455|GO:0043524|GO:0006897|GO:0022008|GO:0030260|GO:0004714|GO:0006464|GO:0071396|GO:0045621|GO:0006915|GO:0071222|GO:2000107|GO:0097028|GO:0032825|GO:0035457|GO:0006468|GO:0048699|GO:0004713|GO:0018193|GO:0006907|GO:0007169|GO:0048010|GO:2000669|GO:0018108 locomotion|developmental process|signal transducer activity|reproduction|immune system process|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|receptor activity|negative regulation of cellular process|regulation of cellular process|leukocyte activation|positive regulation of transport|response to stress|single organism reproductive process|other organism cell|organic substance metabolic process|ion binding|immune response|cell surface|ovulation cycle|sexual reproduction|cellular metabolic process|signaling receptor activity|developmental process involved in reproduction|cell motility|regulation of signaling|anatomical structure morphogenesis|modified amino acid binding|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|multicellular organism reproduction|intrinsic component of membrane|extracellular space|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|transferase activity|anatomical structure development|multicellular organismal reproductive process|viral process|negative regulation of cytokine production|regulation of hemopoiesis|coagulation|innate immune response|regulation of cell differentiation|positive regulation of response to cytokine stimulus|cell development|positive regulation of cell activation|transport|positive regulation of cellular component organization|regulation of cell death|substrate adhesion-dependent cell spreading|response to extracellular stimulus|multicellular organism development|regulation of vesicle-mediated transport|animal organ development|erythrocyte homeostasis|host cell surface|anion binding|secretion by cell|defense response|forebrain development|virus receptor activity|phospholipid binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|regulation of cellular component organization|brain development|regulation of cytokine production|positive regulation of endocytosis|integral component of plasma membrane|positive regulation of cell differentiation|reproductive structure development|transmembrane signaling receptor activity|cytokine production|cellular response to extracellular stimulus|response to wounding|head development|movement of cell or subcellular component|homeostatic process|organic acid binding|positive regulation of leukocyte activation|cell activation|cell-substrate adhesion|regulation of signal transduction|protein dimerization activity|sex differentiation|tissue remodeling|host cell|negative regulation of cell death|regulation of cell communication|intrinsic component of plasma membrane|response to bacterium|lymphocyte activation|regulation of cell activation|phosphatidylserine binding|cell communication|gamete generation|cell migration|signal transduction|extracellular exosome|cell death|negative regulation of leukocyte activation|nucleotide binding|cellular developmental process|integral component of membrane|genitalia development|positive regulation of signal transduction|protein metabolic process|response to organic substance|regulation of body fluid levels|interaction with host|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|cell morphogenesis|phagocytosis|female genitalia development|platelet activation|negative regulation of neuron death|natural killer cell activation|male gamete generation|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|reproductive system development|hemopoiesis|response to cytokine|lymphocyte differentiation|central nervous system development|response to molecule of bacterial origin|negative regulation of programmed cell death|protein heterodimerization activity|blood coagulation|negative regulation of tumor necrosis factor superfamily cytokine production|purine nucleoside binding|neuron death|cell morphogenesis involved in differentiation|positive regulation of pinocytosis|forebrain cell migration|protein modification process|positive regulation of cytokine-mediated signaling pathway|wound healing|cellular response to molecule of bacterial origin|neuron migration|homeostasis of number of cells|inflammatory response|ribonucleoside binding|positive regulation of lymphocyte activation|negative regulation of lymphocyte activation|hemostasis|regulation of endocytosis|kinase activity|regulation of neuron death|blood vessel remodeling|negative regulation of interferon-gamma production|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|interferon-gamma production|carboxylic acid binding|nervous system development|secretion|viral life cycle|cellular response to organic substance|purine nucleotide binding|cell differentiation|cell maturation|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|response to lipopolysaccharide|regulation of programmed cell death|regulation of interferon-gamma production|vagina development|regulation of tumor necrosis factor production|leukocyte differentiation|regulation of protein kinase B signaling|negative regulation of tumor necrosis factor production|protein kinase B signaling|spermatogenesis|cytokine-mediated signaling pathway|positive regulation of natural killer cell activation|regulation of neuron apoptotic process|viral entry into host cell|ATP binding|adenyl nucleotide binding|phosphorylation|positive regulation of protein kinase B signaling|regulation of lymphocyte differentiation|tumor necrosis factor production|enzyme linked receptor protein signaling pathway|natural killer cell differentiation|regulation of apoptotic process|cellular response to cytokine stimulus|amino acid binding|negative regulation of apoptotic process|protein kinase activity|apoptotic cell clearance|neuron apoptotic process|response to interferon-alpha|negative regulation of neuron apoptotic process|endocytosis|neurogenesis|entry into host cell|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|cellular response to lipid|positive regulation of lymphocyte differentiation|apoptotic process|cellular response to lipopolysaccharide|negative regulation of leukocyte apoptotic process|dendritic cell differentiation|positive regulation of natural killer cell differentiation|cellular response to interferon-alpha|protein phosphorylation|generation of neurons|protein tyrosine kinase activity|peptidyl-amino acid modification|pinocytosis|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|negative regulation of dendritic cell apoptotic process|peptidyl-tyrosine phosphorylation - - - - 19:41219203-41261766 149 200 330 1107 1204 819 1.48468767944687 1.81116501138384 2.96467434456762 9.88311924510866 9.84335273016819 7.64824138458094 2.08684234513278 9.12490445328593 -2.12848783932279 6.51698322674159e-16 3.28645299410715e-14 DOWN ENSG00000138759 FRAS1 Fraser extracellular matrix complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:19185] GO:0032502|GO:0031012|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0005604|GO:0061618|GO:0005578|GO:0043167|GO:0009653|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0001822|GO:0009888|GO:0006810|GO:0007275|GO:0048513|GO:0043169|GO:0009887|GO:0048729|GO:0048598|GO:0045184|GO:0008104|GO:0007154|GO:0016021|GO:0060021|GO:0046872|GO:0002009|GO:0001655|GO:0015031|GO:0009790|GO:0001656|GO:0072001|GO:0043588|GO:0060993|GO:0060429|GO:0035108|GO:0060173|GO:0003338|GO:0030326 developmental process|extracellular matrix|cell|membrane|cellular process|extracellular region|binding|basement membrane|sublamina densa|proteinaceous extracellular matrix|ion binding|anatomical structure morphogenesis|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|kidney development|tissue development|transport|multicellular organism development|animal organ development|cation binding|organ morphogenesis|tissue morphogenesis|embryonic morphogenesis|establishment of protein localization|protein localization|cell communication|integral component of membrane|palate development|metal ion binding|morphogenesis of an epithelium|urogenital system development|protein transport|embryo development|metanephros development|renal system development|skin development|kidney morphogenesis|epithelium development|limb morphogenesis|limb development|metanephros morphogenesis|embryonic limb morphogenesis - - - - 4:78057570-78544269 24 27 57 227 248 356 0.0703610648087226 0.0719407982755614 0.150665154230855 0.596277049699981 0.596545982119676 0.978145186421772 0.0976556724383797 0.723656072747143 -2.8895284478215 6.59343330536293e-16 3.31939895275388e-14 DOWN ENSG00000170836 PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D [Source:HGNC Symbol;Acc:HGNC:9277] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0016787|GO:0005622|GO:0005515|GO:0042127|GO:0007049|GO:0009314|GO:0022402|GO:0009991|GO:0016788|GO:0033554|GO:0043231|GO:0043169|GO:0019899|GO:0031668|GO:0009617|GO:0007154|GO:0008285|GO:0019538|GO:0042594|GO:0046872|GO:1903047|GO:0043412|GO:0044770|GO:0036211|GO:0000278|GO:0009267|GO:0019900|GO:0006796|GO:0044267|GO:0031669|GO:0031667|GO:0005634|GO:0042578|GO:0016311|GO:0000086|GO:0044772|GO:0016791|GO:0019901|GO:0006464|GO:0006470|GO:0004721|GO:0051019|GO:0004722|GO:0035970 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|hydrolase activity|intracellular|protein binding|regulation of cell proliferation|cell cycle|response to radiation|cell cycle process|response to extracellular stimulus|hydrolase activity, acting on ester bonds|cellular response to stress|intracellular membrane-bounded organelle|cation binding|enzyme binding|cellular response to extracellular stimulus|response to bacterium|cell communication|negative regulation of cell proliferation|protein metabolic process|response to starvation|metal ion binding|mitotic cell cycle process|macromolecule modification|cell cycle phase transition|protein modification process|mitotic cell cycle|cellular response to starvation|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|cellular response to nutrient levels|response to nutrient levels|nucleus|phosphoric ester hydrolase activity|dephosphorylation|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|phosphatase activity|protein kinase binding|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|mitogen-activated protein kinase binding|protein serine/threonine phosphatase activity|peptidyl-threonine dephosphorylation K10147 protein phosphatase 1D[3.1.3.16] hsa04115 p53 signaling pathway - Homo sapiens (human) 17:60600183-60666280 566 581 546 161 187 179 5.50035058871144 5.13133025588642 4.78388266427438 1.40183605159145 1.4910174102226 1.63025542991757 5.13852116962408 1.50770296391054 1.76900099375769 7.24904261296482e-16 3.64331512066417e-14 UP ENSG00000154310 TNIK TRAF2 and NCK interacting kinase [Source:HGNC Symbol;Acc:HGNC:30765] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0006914|GO:0045177|GO:0023051|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0045595|GO:0048468|GO:0010941|GO:0016324|GO:0007275|GO:0050688|GO:0016358|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0051128|GO:0033554|GO:0022607|GO:0098542|GO:0043231|GO:0005737|GO:0009615|GO:0009966|GO:0010646|GO:0043085|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0070062|GO:0008219|GO:0016236|GO:0051607|GO:0050790|GO:0000166|GO:0030030|GO:0048869|GO:0030029|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0010256|GO:0005768|GO:0006996|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0031344|GO:0098792|GO:0007166|GO:0035639|GO:0043412|GO:0007010|GO:0050773|GO:0048813|GO:0032528|GO:0001883|GO:0000904|GO:0007009|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0055037|GO:0072657|GO:0031981|GO:0031098|GO:0007346|GO:0030031|GO:0051247|GO:0005654|GO:0022604|GO:0016301|GO:0030036|GO:0034613|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0017076|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0016773|GO:0005856|GO:0005634|GO:0043067|GO:0051960|GO:0050691|GO:0048666|GO:0030182|GO:0016055|GO:0070304|GO:0010975|GO:0030033|GO:0031401|GO:0031532|GO:0043408|GO:0010769|GO:0072659|GO:0005524|GO:0030554|GO:0016310|GO:0002230|GO:0048814|GO:0043410|GO:0032872|GO:0042981|GO:0004672|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:1990778|GO:0051403|GO:0043549|GO:0006915|GO:0033674|GO:0000186|GO:0045859|GO:0045860|GO:0046328|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0004674|GO:0032874|GO:0001934|GO:0045664|GO:0042327|GO:0046330|GO:0046777|GO:0007256|GO:0071900|GO:0043506|GO:0032147 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|autophagy|apical part of cell|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|regulation of cell differentiation|cell development|regulation of cell death|apical plasma membrane|multicellular organism development|regulation of defense response to virus|dendrite development|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|response to virus|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|protein localization|cell communication|membrane organization|signal transduction|extracellular exosome|cell death|macroautophagy|defense response to virus|regulation of catalytic activity|nucleotide binding|cell projection organization|cellular developmental process|actin filament-based process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|endomembrane system organization|endosome|organelle organization|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|regulation of cell projection organization|xenophagy|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|regulation of dendrite development|dendrite morphogenesis|microvillus organization|purine nucleoside binding|cell morphogenesis involved in differentiation|plasma membrane organization|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|recycling endosome|protein localization to membrane|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|cell projection assembly|positive regulation of protein metabolic process|nucleoplasm|regulation of cell morphogenesis|kinase activity|actin cytoskeleton organization|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|regulation of programmed cell death|regulation of nervous system development|regulation of defense response to virus by host|neuron development|neuron differentiation|Wnt signaling pathway|positive regulation of stress-activated protein kinase signaling cascade|regulation of neuron projection development|microvillus assembly|positive regulation of protein modification process|actin cytoskeleton reorganization|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|protein localization to plasma membrane|ATP binding|adenyl nucleotide binding|phosphorylation|positive regulation of defense response to virus by host|regulation of dendrite morphogenesis|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|protein kinase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|protein localization to cell periphery|stress-activated MAPK cascade|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|activation of MAPKK activity|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of JNK cascade|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|regulation of neuron differentiation|positive regulation of phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|activation of JNKK activity|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|activation of protein kinase activity - - - - 3:171061339-171460408 105 114 186 583 563 706 0.609501767994114 0.60140755268455 0.973443618055147 3.03215056332264 2.68139452176265 3.84076720227739 0.728117646244604 3.18477076245423 -2.12894605296868 7.39826471309976e-16 3.71206377722488e-14 DOWN ENSG00000188158 NHS NHS actin remodeling regulator [Source:HGNC Symbol;Acc:HGNC:7820] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0042995|GO:0030055|GO:0045177|GO:0005911|GO:0071944|GO:0031252|GO:0005622|GO:0005886|GO:0048856|GO:0016324|GO:0002088|GO:0007275|GO:0048513|GO:0005924|GO:0005912|GO:0005737|GO:0007423|GO:0030027|GO:0048869|GO:0043296|GO:0001654|GO:0030154|GO:0005923|GO:0005925|GO:0043010 developmental process|cell|membrane|cellular process|cell junction|cell projection|cell-substrate junction|apical part of cell|cell-cell junction|cell periphery|cell leading edge|intracellular|plasma membrane|anatomical structure development|apical plasma membrane|lens development in camera-type eye|multicellular organism development|animal organ development|cell-substrate adherens junction|adherens junction|cytoplasm|sensory organ development|lamellipodium|cellular developmental process|apical junction complex|eye development|cell differentiation|bicellular tight junction|focal adhesion|camera-type eye development - - - - X:17375420-17735994 46 60 120 435 491 412 0.173901791326674 0.206148154815038 0.409019613839154 1.47345097375332 1.52299305317424 1.45973931999303 0.263023186660289 1.48539444897353 -2.49758420177549 7.44354151518704e-16 3.72851490594621e-14 DOWN ENSG00000140836 ZFHX3 zinc finger homeobox 3 [Source:HGNC Symbol;Acc:HGNC:777] GO:0032502|GO:0032991|GO:0007610|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0042752|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0007622|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0043167|GO:0044237|GO:0050795|GO:0043227|GO:0044708|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0007626|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0045595|GO:0006725|GO:0048468|GO:1904059|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0045475|GO:0034641|GO:0031325|GO:0046483|GO:0007420|GO:0032922|GO:0061061|GO:0045786|GO:0045597|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0000981|GO:0060322|GO:0071559|GO:0005667|GO:0009890|GO:0006139|GO:0048869|GO:0044249|GO:0048512|GO:0010033|GO:0031324|GO:0031323|GO:0005730|GO:0003677|GO:0051149|GO:0010468|GO:0034645|GO:0046872|GO:0007417|GO:0010629|GO:0042692|GO:0051252|GO:0007050|GO:0010628|GO:0051147|GO:0003705|GO:0031981|GO:0070848|GO:0005654|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0007517|GO:0016070|GO:0010557|GO:0005634|GO:0051148|GO:0051960|GO:0030182|GO:0000975|GO:0045893|GO:0045445|GO:0045663|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0045661|GO:0016604|GO:0003690|GO:0046914|GO:0022008|GO:0050767|GO:0045662|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0000122|GO:0008270|GO:0045664|GO:0001047|GO:0000976|GO:0001046 developmental process|macromolecular complex|behavior|cell|rhythmic process|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|regulation of circadian rhythm|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|rhythmic behavior|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|ion binding|cellular metabolic process|regulation of behavior|membrane-bounded organelle|single-organism behavior|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|locomotory behavior|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|regulation of locomotor rhythm|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|locomotor rhythm|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|circadian regulation of gene expression|muscle structure development|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|response to transforming growth factor beta|transcription factor complex|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|circadian behavior|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|nucleolus|DNA binding|positive regulation of muscle cell differentiation|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|central nervous system development|negative regulation of gene expression|muscle cell differentiation|regulation of RNA metabolic process|cell cycle arrest|positive regulation of gene expression|regulation of muscle cell differentiation|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nuclear lumen|response to growth factor|nucleoplasm|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|muscle organ development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|negative regulation of muscle cell differentiation|regulation of nervous system development|neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|myoblast differentiation|positive regulation of myoblast differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of myoblast differentiation|nuclear body|double-stranded DNA binding|transition metal ion binding|neurogenesis|regulation of neurogenesis|negative regulation of myoblast differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|regulation of neuron differentiation|core promoter binding|transcription regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding K09378 AT-binding transcription factor 1[-] hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) 16:72782885-73059698 332 394 495 1302 1472 1284 1.30993993049828 1.41283232198065 1.76089365149216 4.60280639284811 4.76529250042359 4.74797052716706 1.4945553013237 4.70535647347959 -1.65458774394247 7.70168637746529e-16 3.85135921462058e-14 DOWN ENSG00000231683 RP1-27K12.2 - - - - - - - 6:53561289-53617171 77 91 171 529 575 725 0.51617856902292 0.554413847029302 1.03352412091037 3.1773454283837 3.16261768067354 4.55489289607469 0.701372178987531 3.63161866837731 -2.37236061286153 7.84002873761304e-16 3.9139835774699e-14 DOWN ENSG00000134030 CTIF CBP80/20-dependent translation initiation factor [Source:HGNC Symbol;Acc:HGNC:23925] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0006413|GO:0005737|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0006446|GO:0044265|GO:0048471|GO:0043603|GO:0044267|GO:0010467|GO:0019439|GO:0051246|GO:0009059|GO:0016070|GO:0006401|GO:0043043|GO:0010608|GO:0006412|GO:0016071|GO:0006417|GO:0006402|GO:0000956|GO:0000184 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|translational initiation|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|regulation of translational initiation|cellular macromolecule catabolic process|perinuclear region of cytoplasm|cellular amide metabolic process|cellular protein metabolic process|gene expression|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|RNA catabolic process|peptide biosynthetic process|posttranscriptional regulation of gene expression|translation|mRNA metabolic process|regulation of translation|mRNA catabolic process|nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay - - - - 18:48539046-48863217 75 53 110 398 439 629 0.355412951995278 0.22826136764578 0.469979599020384 1.68987377240997 1.70689167110487 2.79352529524448 0.351217972887147 2.06343024625311 -2.55460609027316 8.07684164559897e-16 4.02547630196513e-14 DOWN ENSG00000177694 NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 [Source:HGNC Symbol;Acc:HGNC:23219] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 3:174438573-175810552 9 7 24 124 130 204 0.0361088535538503 0.0255255821684168 0.08681336847413 0.445747220826914 0.427937427850125 0.767057141345592 0.049482601398799 0.546913930007544 -3.46632055552922 8.71170710538535e-16 4.3346550654029e-14 DOWN ENSG00000027869 SH2D2A SH2 domain containing 2A [Source:HGNC Symbol;Acc:HGNC:10821] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0008283|GO:0050794|GO:0023051|GO:0009653|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0048514|GO:0035591|GO:0001568|GO:0007275|GO:0005737|GO:0009966|GO:0030674|GO:0019904|GO:0010646|GO:0001525|GO:0007154|GO:0007165|GO:0048869|GO:0009967|GO:0005829|GO:0007166|GO:0001944|GO:0072358|GO:0017124|GO:0030154|GO:0072359|GO:0005070|GO:0007167|GO:0007169|GO:0048010 developmental process|signaling|cell|cellular process|response to stimulus|binding|binding, bridging|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of signaling|anatomical structure morphogenesis|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|signaling adaptor activity|blood vessel development|multicellular organism development|cytoplasm|regulation of signal transduction|protein binding, bridging|protein domain specific binding|regulation of cell communication|angiogenesis|cell communication|signal transduction|cellular developmental process|positive regulation of signal transduction|cytosol|cell surface receptor signaling pathway|vasculature development|cardiovascular system development|SH3 domain binding|cell differentiation|circulatory system development|SH3/SH2 adaptor activity|enzyme linked receptor protein signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway K08273 SH2 domain protein 2A[-] hsa04370 VEGF signaling pathway - Homo sapiens (human) 1:156806243-156816862 3 5 5 62 72 47 0.0537436868369065 0.0814046429610578 0.0807437036735119 0.995058147682872 1.05817944397479 0.789023330781251 0.0719640111571587 0.947420307479638 -3.7186570882734 8.77775052701529e-16 4.36024898891039e-14 DOWN ENSG00000114529 C3orf52 chromosome 3 open reading frame 52 [Source:HGNC Symbol;Acc:HGNC:26255] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0042175|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0005737|GO:0005783|GO:0016021 cell|membrane|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane - - - - 3:112086335-112131004 71 52 101 352 418 384 0.51258571980413 0.341185926527007 0.657421553458228 2.27692291274355 2.47601217467354 2.59817304335699 0.503731066596455 2.45036937692469 -2.28227362816956 9.71641077587545e-16 4.81850045353797e-14 DOWN ENSG00000123636 BAZ2B bromodomain adjacent to zinc finger domain 2B [Source:HGNC Symbol;Acc:HGNC:963] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0008270 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 2:159318979-159616692 80 103 109 390 412 479 0.227358380058208 0.266035457565369 0.279294527792584 0.993077500197226 0.960695225578268 1.27580922019686 0.257562788472054 1.07652731532412 -2.06338884682284 1.06029204344062e-15 5.24866377886991e-14 DOWN ENSG00000260917 RP11-57H14.4 - - - - - - - 10:112823490-112827726 6 11 21 108 109 153 0.100165536391076 0.166908366185422 0.316097644029765 1.61550049768467 1.49307531349883 2.39390803500073 0.194390515535421 1.83416128206141 -3.23809076847711 1.0618988820384e-15 5.24866377886991e-14 DOWN ENSG00000141198 TOM1L1 target of myb1 like 1 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11983] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0051726|GO:0007049|GO:0032182|GO:0006810|GO:0022402|GO:0051302|GO:0008047|GO:0031982|GO:0031325|GO:0051128|GO:0030276|GO:0045786|GO:0043231|GO:0019899|GO:0005737|GO:0051782|GO:0045184|GO:0019904|GO:0043085|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0051649|GO:0010008|GO:0050790|GO:0051301|GO:0019207|GO:0019538|GO:0031323|GO:0005794|GO:0005768|GO:0006996|GO:0032268|GO:0005829|GO:1903047|GO:0043412|GO:0030163|GO:0019887|GO:0043130|GO:0017124|GO:0015031|GO:0044265|GO:0005773|GO:0051347|GO:0036211|GO:0000278|GO:0046907|GO:0007346|GO:0010564|GO:0051247|GO:0045930|GO:0006508|GO:0034613|GO:0019900|GO:0032270|GO:0006796|GO:0005795|GO:0033043|GO:0044267|GO:0051174|GO:0007067|GO:0019209|GO:0051246|GO:0010948|GO:0044257|GO:0031401|GO:0000323|GO:0007088|GO:0016310|GO:0006886|GO:0051603|GO:0045839|GO:0030295|GO:0019901|GO:0006464|GO:0043549|GO:0033674|GO:0045859|GO:0045860|GO:0005764|GO:0019941|GO:0006468|GO:0042325|GO:0001932|GO:0001934|GO:0042327|GO:0006511|GO:0046777|GO:0031952|GO:0031954|GO:0032147|GO:0043162 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cell cycle|cell cycle|ubiquitin-like protein binding|transport|cell cycle process|regulation of cell division|enzyme activator activity|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|clathrin binding|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|negative regulation of cell division|establishment of protein localization|protein domain specific binding|positive regulation of catalytic activity|protein localization|cell communication|signal transduction|extracellular exosome|establishment of localization in cell|endosome membrane|regulation of catalytic activity|cell division|kinase regulator activity|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|endosome|organelle organization|regulation of cellular protein metabolic process|cytosol|mitotic cell cycle process|macromolecule modification|protein catabolic process|protein kinase regulator activity|ubiquitin binding|SH3 domain binding|protein transport|cellular macromolecule catabolic process|vacuole|positive regulation of transferase activity|protein modification process|mitotic cell cycle|intracellular transport|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|proteolysis|cellular protein localization|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|Golgi stack|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|kinase activator activity|regulation of protein metabolic process|negative regulation of cell cycle process|cellular protein catabolic process|positive regulation of protein modification process|lytic vacuole|regulation of mitotic nuclear division|phosphorylation|intracellular protein transport|proteolysis involved in cellular protein catabolic process|negative regulation of mitotic nuclear division|protein kinase activator activity|protein kinase binding|cellular protein modification process|regulation of kinase activity|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|lysosome|modification-dependent protein catabolic process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|ubiquitin-dependent protein catabolic process|protein autophosphorylation|regulation of protein autophosphorylation|positive regulation of protein autophosphorylation|activation of protein kinase activity|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway - - - - 17:54899387-54961956 310 330 466 1181 1264 1251 1.62072420015999 1.56798297753828 2.19658324096258 5.53216956831456 5.42204312871049 6.12963074254137 1.79509680622028 5.69461447985547 -1.66553652811946 1.07132256502324e-15 5.28648989358742e-14 DOWN ENSG00000240875 LINC00886 long intergenic non-protein coding RNA 886 [Source:HGNC Symbol;Acc:HGNC:48572] - - - - - - 3:156747346-156817062 31 26 54 200 238 237 0.500191569985507 0.381265933863095 0.785572093856932 2.89135987542943 3.15078961362586 3.58387229095129 0.555676532568511 3.20867392666886 -2.52965996832201 1.08008288333272e-15 5.32092316815431e-14 DOWN ENSG00000151276 MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 [Source:HGNC Symbol;Acc:HGNC:946] GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0032947|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0008022|GO:0043168|GO:0005912|GO:0001882|GO:0022607|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0008092|GO:0008219|GO:0000166|GO:0043296|GO:0007166|GO:0035639|GO:0001883|GO:0070997|GO:0032549|GO:0042805|GO:0031981|GO:0005654|GO:0006461|GO:0017076|GO:0005923|GO:0005634|GO:0051393|GO:0005524|GO:0030554 structural molecule activity|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|protein complex scaffold|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein C-terminus binding|anion binding|adherens junction|nucleoside binding|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|cytoskeletal protein binding|cell death|nucleotide binding|apical junction complex|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|purine nucleoside binding|neuron death|ribonucleoside binding|actinin binding|nuclear lumen|nucleoplasm|protein complex assembly|purine nucleotide binding|bicellular tight junction|nucleus|alpha-actinin binding|ATP binding|adenyl nucleotide binding - - - - 3:65353525-66038834 55 44 115 384 507 472 0.194486683389388 0.141403783817189 0.366642127011483 1.21662736773985 1.4709721960533 1.56422819217684 0.23417753140602 1.41727591865666 -2.59744608734882 1.09712123944227e-15 5.39595675161606e-14 DOWN ENSG00000150630 VEGFC vascular endothelial growth factor C [Source:HGNC Symbol;Acc:HGNC:12682] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0042056|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0006950|GO:0048520|GO:0071704|GO:0050900|GO:0044237|GO:0051641|GO:0050795|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0007155|GO:0043227|GO:0009605|GO:0009893|GO:0005615|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0001946|GO:0060341|GO:0008284|GO:0051272|GO:0042127|GO:0050817|GO:0006935|GO:0045595|GO:0009888|GO:0002685|GO:0048468|GO:0006810|GO:0001568|GO:0007275|GO:0010632|GO:0048513|GO:0051302|GO:0001945|GO:0005102|GO:0032940|GO:0030155|GO:0031982|GO:0031325|GO:2000147|GO:0090287|GO:0030141|GO:0045597|GO:0043231|GO:0005737|GO:0009611|GO:0050920|GO:0032880|GO:0051222|GO:0006928|GO:0009887|GO:0002687|GO:0001775|GO:0031589|GO:0009966|GO:0048729|GO:0048598|GO:0050673|GO:0045184|GO:0042493|GO:0010646|GO:0001525|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0045785|GO:0061351|GO:0010634|GO:0008285|GO:0008217|GO:0030595|GO:0051047|GO:0036303|GO:0031983|GO:0051781|GO:0051301|GO:0048869|GO:2000145|GO:0019538|GO:0010033|GO:0031323|GO:0050878|GO:0003013|GO:0050921|GO:0072089|GO:0016192|GO:0050679|GO:0032268|GO:0005126|GO:0090132|GO:0030168|GO:0002688|GO:0007166|GO:0002009|GO:0070851|GO:0001944|GO:0043412|GO:0072358|GO:0031410|GO:0010720|GO:1901492|GO:0030947|GO:0002690|GO:0007596|GO:0007405|GO:0051223|GO:0015031|GO:0009790|GO:0030334|GO:0050927|GO:0001667|GO:0016023|GO:0006887|GO:0036211|GO:0070201|GO:0007160|GO:0042060|GO:0050714|GO:0045766|GO:0051046|GO:0016331|GO:0002551|GO:0060326|GO:0050769|GO:0045765|GO:0045776|GO:0007599|GO:0009306|GO:0010810|GO:0051247|GO:0070848|GO:0031988|GO:0050678|GO:0032270|GO:0060429|GO:0006796|GO:1901342|GO:0006929|GO:0060205|GO:0044267|GO:0051174|GO:0050918|GO:2000179|GO:0007399|GO:0046903|GO:0071310|GO:0010594|GO:0051246|GO:0010811|GO:0030154|GO:0034774|GO:0030335|GO:2000177|GO:0097531|GO:0008083|GO:0072359|GO:0031091|GO:0008015|GO:0051960|GO:2000648|GO:0010595|GO:0072091|GO:0043536|GO:0045055|GO:0031401|GO:0050930|GO:1902692|GO:0050708|GO:0071363|GO:0043535|GO:0016310|GO:0007167|GO:0001952|GO:0060753|GO:0001954|GO:0010631|GO:0022008|GO:0006464|GO:0050767|GO:0031093|GO:0005172|GO:0060754|GO:0002052|GO:0006468|GO:0048699|GO:0042325|GO:0043185|GO:0001932|GO:0018193|GO:0001934|GO:0002576|GO:0043542|GO:0042327|GO:0007169|GO:0048010|GO:0050731|GO:0050730|GO:0046777|GO:0031952|GO:0031954|GO:0018108|GO:0043534 locomotion|developmental process|immune system process|behavior|signaling|chemoattractant activity|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|response to stress|positive regulation of behavior|organic substance metabolic process|leukocyte migration|cellular metabolic process|cellular localization|regulation of behavior|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cell adhesion|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|extracellular space|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|lymphangiogenesis|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|coagulation|chemotaxis|regulation of cell differentiation|tissue development|regulation of leukocyte migration|cell development|transport|blood vessel development|multicellular organism development|regulation of epithelial cell migration|animal organ development|regulation of cell division|lymph vessel development|receptor binding|secretion by cell|regulation of cell adhesion|vesicle|positive regulation of cellular metabolic process|positive regulation of cell motility|regulation of cellular response to growth factor stimulus|secretory granule|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|response to wounding|regulation of chemotaxis|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|organ morphogenesis|positive regulation of leukocyte migration|cell activation|cell-substrate adhesion|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|epithelial cell proliferation|establishment of protein localization|response to drug|regulation of cell communication|angiogenesis|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|positive regulation of cell adhesion|neural precursor cell proliferation|positive regulation of epithelial cell migration|negative regulation of cell proliferation|regulation of blood pressure|leukocyte chemotaxis|positive regulation of secretion|lymph vessel morphogenesis|vesicle lumen|positive regulation of cell division|cell division|cellular developmental process|regulation of cell motility|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|positive regulation of chemotaxis|stem cell proliferation|vesicle-mediated transport|positive regulation of epithelial cell proliferation|regulation of cellular protein metabolic process|cytokine receptor binding|epithelium migration|platelet activation|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|morphogenesis of an epithelium|growth factor receptor binding|vasculature development|macromolecule modification|cardiovascular system development|cytoplasmic vesicle|positive regulation of cell development|positive regulation of lymphangiogenesis|regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of leukocyte chemotaxis|blood coagulation|neuroblast proliferation|regulation of protein transport|protein transport|embryo development|regulation of cell migration|positive regulation of positive chemotaxis|ameboidal-type cell migration|cytoplasmic, membrane-bounded vesicle|exocytosis|protein modification process|regulation of establishment of protein localization|cell-matrix adhesion|wound healing|positive regulation of protein secretion|positive regulation of angiogenesis|regulation of secretion|morphogenesis of embryonic epithelium|mast cell chemotaxis|cell chemotaxis|positive regulation of neurogenesis|regulation of angiogenesis|negative regulation of blood pressure|hemostasis|protein secretion|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|response to growth factor|membrane-bounded vesicle|regulation of epithelial cell proliferation|positive regulation of cellular protein metabolic process|epithelium development|phosphate-containing compound metabolic process|regulation of vasculature development|substrate-dependent cell migration|cytoplasmic membrane-bounded vesicle lumen|cellular protein metabolic process|regulation of phosphorus metabolic process|positive chemotaxis|positive regulation of neural precursor cell proliferation|nervous system development|secretion|cellular response to organic substance|regulation of endothelial cell migration|regulation of protein metabolic process|positive regulation of cell-substrate adhesion|cell differentiation|secretory granule lumen|positive regulation of cell migration|regulation of neural precursor cell proliferation|mast cell migration|growth factor activity|circulatory system development|platelet alpha granule|blood circulation|regulation of nervous system development|positive regulation of stem cell proliferation|positive regulation of endothelial cell migration|regulation of stem cell proliferation|positive regulation of blood vessel endothelial cell migration|regulated exocytosis|positive regulation of protein modification process|induction of positive chemotaxis|regulation of neuroblast proliferation|regulation of protein secretion|cellular response to growth factor stimulus|regulation of blood vessel endothelial cell migration|phosphorylation|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|regulation of mast cell chemotaxis|positive regulation of cell-matrix adhesion|epithelial cell migration|neurogenesis|cellular protein modification process|regulation of neurogenesis|platelet alpha granule lumen|vascular endothelial growth factor receptor binding|positive regulation of mast cell chemotaxis|positive regulation of neuroblast proliferation|protein phosphorylation|generation of neurons|regulation of phosphorylation|vascular endothelial growth factor receptor 3 binding|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|platelet degranulation|endothelial cell migration|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of protein autophosphorylation|positive regulation of protein autophosphorylation|peptidyl-tyrosine phosphorylation|blood vessel endothelial cell migration K05449 vascular endothelial growth factor C/D[-] hsa05200|hsa04151|hsa04060|hsa04014|hsa04015|hsa04510|hsa04668|hsa04933 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) 4:176683538-176792727 121 92 161 527 611 526 3.45128702132895 2.38485152873967 4.14033578719064 13.4679787318916 14.2989298948669 14.060755688389 3.32549144575309 13.9425547717158 -2.06785547348815 1.10406280086994e-15 5.42116625940314e-14 DOWN ENSG00000127666 TICAM1 toll-like receptor adaptor molecule 1 [Source:HGNC Symbol;Acc:HGNC:18348] GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0008284|GO:1903409|GO:0002757|GO:0042127|GO:0045087|GO:0006725|GO:0070661|GO:0050867|GO:1901360|GO:0010941|GO:0002281|GO:0034641|GO:0006952|GO:2001057|GO:0031982|GO:0031325|GO:0046483|GO:0010942|GO:0098542|GO:0001817|GO:0051098|GO:0043231|GO:0019899|GO:0005737|GO:0002218|GO:0001816|GO:0072593|GO:0009615|GO:0002696|GO:0001775|GO:0009966|GO:0002263|GO:0001819|GO:0010646|GO:0006139|GO:0043085|GO:0009617|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0002366|GO:0050778|GO:0008219|GO:0051607|GO:0010008|GO:0050790|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0005768|GO:0051090|GO:0042107|GO:1902533|GO:0051249|GO:2001235|GO:0032268|GO:0005829|GO:0042113|GO:0010468|GO:0034645|GO:0030101|GO:0032943|GO:0042089|GO:0032479|GO:0007166|GO:0033993|GO:0032675|GO:0043412|GO:0002758|GO:0031410|GO:0051345|GO:0032635|GO:0002237|GO:0032642|GO:0051252|GO:0051604|GO:0005773|GO:0032481|GO:0010628|GO:0032755|GO:0045359|GO:0036211|GO:2000377|GO:0043331|GO:0071219|GO:0006954|GO:0046209|GO:0032602|GO:0051251|GO:1903428|GO:0051091|GO:0042035|GO:0032606|GO:0051099|GO:0051247|GO:0006508|GO:0045428|GO:0002764|GO:0042116|GO:0042108|GO:0019900|GO:0032270|GO:0012501|GO:0014070|GO:0097342|GO:0035556|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0006809|GO:0051246|GO:0046651|GO:0009059|GO:0043068|GO:1902531|GO:0016070|GO:0010557|GO:0032496|GO:0043067|GO:0045089|GO:1903426|GO:0032722|GO:0097190|GO:0045088|GO:0043393|GO:2000379|GO:0032680|GO:0045893|GO:0031401|GO:0043122|GO:0032816|GO:0043065|GO:0043496|GO:0016485|GO:0097296|GO:0045351|GO:0032774|GO:0032728|GO:0030162|GO:2001141|GO:0045862|GO:0051092|GO:0052547|GO:0050871|GO:0032640|GO:0002221|GO:0005776|GO:0043123|GO:0032092|GO:0007249|GO:0050864|GO:2001269|GO:0045080|GO:0032608|GO:0050755|GO:0042981|GO:0045429|GO:0042100|GO:0032760|GO:0019901|GO:0043330|GO:0006464|GO:0010952|GO:0032648|GO:0071396|GO:0042033|GO:0097191|GO:0050671|GO:0006351|GO:0006915|GO:0006355|GO:0071222|GO:0032946|GO:0031663|GO:0030890|GO:0010950|GO:0002224|GO:0043281|GO:1903506|GO:0031638|GO:0030888|GO:0043280|GO:0006919|GO:0052548|GO:0032446|GO:0031398|GO:2001056|GO:0002756|GO:0031396|GO:0034138|GO:2000116|GO:0034142|GO:0097202|GO:0016567|GO:0035666 macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|positive regulation of cell proliferation|reactive oxygen species biosynthetic process|immune response-activating signal transduction|regulation of cell proliferation|innate immune response|cellular aromatic compound metabolic process|leukocyte proliferation|positive regulation of cell activation|organic cyclic compound metabolic process|regulation of cell death|macrophage activation involved in immune response|cellular nitrogen compound metabolic process|defense response|reactive nitrogen species metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell death|defense response to other organism|regulation of cytokine production|regulation of binding|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|activation of innate immune response|cytokine production|reactive oxygen species metabolic process|response to virus|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|cell activation involved in immune response|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|cell death|defense response to virus|endosome membrane|regulation of catalytic activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|endosome|regulation of sequence-specific DNA binding transcription factor activity|cytokine metabolic process|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cytosol|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|natural killer cell activation|mononuclear cell proliferation|cytokine biosynthetic process|regulation of type I interferon production|cell surface receptor signaling pathway|response to lipid|regulation of interleukin-6 production|macromolecule modification|innate immune response-activating signal transduction|cytoplasmic vesicle|positive regulation of hydrolase activity|interleukin-6 production|response to molecule of bacterial origin|regulation of chemokine production|regulation of RNA metabolic process|protein maturation|vacuole|positive regulation of type I interferon production|positive regulation of gene expression|positive regulation of interleukin-6 production|positive regulation of interferon-beta biosynthetic process|protein modification process|regulation of reactive oxygen species metabolic process|response to dsRNA|cellular response to molecule of bacterial origin|inflammatory response|nitric oxide metabolic process|chemokine production|positive regulation of lymphocyte activation|positive regulation of reactive oxygen species biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of cytokine biosynthetic process|type I interferon production|positive regulation of binding|positive regulation of protein metabolic process|proteolysis|regulation of nitric oxide biosynthetic process|immune response-regulating signaling pathway|macrophage activation|positive regulation of cytokine biosynthetic process|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|ripoptosome|intracellular signal transduction|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|lymphocyte proliferation|macromolecule biosynthetic process|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|regulation of programmed cell death|positive regulation of innate immune response|regulation of reactive oxygen species biosynthetic process|positive regulation of chemokine production|apoptotic signaling pathway|regulation of innate immune response|regulation of protein binding|positive regulation of reactive oxygen species metabolic process|regulation of tumor necrosis factor production|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of natural killer cell activation|positive regulation of apoptotic process|regulation of protein homodimerization activity|protein processing|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|type I interferon biosynthetic process|RNA biosynthetic process|positive regulation of interferon-beta production|regulation of proteolysis|regulation of RNA biosynthetic process|positive regulation of proteolysis|positive regulation of NF-kappaB transcription factor activity|regulation of peptidase activity|positive regulation of B cell activation|tumor necrosis factor production|pattern recognition receptor signaling pathway|autophagosome|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of protein binding|I-kappaB kinase/NF-kappaB signaling|regulation of B cell activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|positive regulation of chemokine biosynthetic process|interferon-beta production|chemokine metabolic process|regulation of apoptotic process|positive regulation of nitric oxide biosynthetic process|B cell proliferation|positive regulation of tumor necrosis factor production|protein kinase binding|response to exogenous dsRNA|cellular protein modification process|positive regulation of peptidase activity|regulation of interferon-beta production|cellular response to lipid|chemokine biosynthetic process|extrinsic apoptotic signaling pathway|positive regulation of lymphocyte proliferation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular response to lipopolysaccharide|positive regulation of mononuclear cell proliferation|lipopolysaccharide-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of endopeptidase activity|toll-like receptor signaling pathway|regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of nucleic acid-templated transcription|zymogen activation|regulation of B cell proliferation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of endopeptidase activity|protein modification by small protein conjugation|positive regulation of protein ubiquitination|positive regulation of cysteine-type endopeptidase activity|MyD88-independent toll-like receptor signaling pathway|regulation of protein ubiquitination|toll-like receptor 3 signaling pathway|regulation of cysteine-type endopeptidase activity|toll-like receptor 4 signaling pathway|activation of cysteine-type endopeptidase activity|protein ubiquitination|TRIF-dependent toll-like receptor signaling pathway K05842 toll-like receptor adapter molecule 1[-] hsa05168|hsa05164|hsa05161|hsa05160|hsa04620|hsa05142|hsa04064|hsa05133 Herpes simplex infection - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Pertussis - Homo sapiens (human) 19:4815932-4831704 969 957 890 341 332 259 15.8446685512699 14.2216919472129 13.1208963969701 4.99586994440409 4.45415631186028 3.96906936479229 14.3957522984843 4.47303187368555 1.68631823998694 1.12462896997181e-15 5.51308263867628e-14 UP ENSG00000148219 ASTN2 astrotactin 2 [Source:HGNC Symbol;Acc:HGNC:17021] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0051641|GO:0043227|GO:0060187|GO:1903828|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0060341|GO:0043231|GO:0005737|GO:0032880|GO:2000009|GO:0008104|GO:0016021|GO:0005768|GO:0034613|GO:1903827|GO:2000008|GO:0034394 cell|membrane|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|cellular localization|membrane-bounded organelle|cell pole|negative regulation of cellular protein localization|intrinsic component of membrane|intracellular|protein binding|endomembrane system|regulation of cellular localization|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|negative regulation of protein localization to cell surface|protein localization|integral component of membrane|endosome|cellular protein localization|regulation of cellular protein localization|regulation of protein localization to cell surface|protein localization to cell surface - - - - 9:116425225-117415070 4 7 7 72 58 75 0.0249677243022115 0.0397142198386301 0.039394016043075 0.402690888745853 0.297053844526042 0.438763285746777 0.0346919867279722 0.379502673006224 -3.45143567938656 1.2277985262697e-15 6.00896675463205e-14 DOWN ENSG00000155111 CDK19 cyclin-dependent kinase 19 [Source:HGNC Symbol;Acc:HGNC:19338] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0005515|GO:0016740|GO:0051726|GO:0007049|GO:0010941|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0010942|GO:0043231|GO:0019899|GO:0005737|GO:0009611|GO:0009617|GO:0008219|GO:0000166|GO:0019538|GO:0010033|GO:0005829|GO:0033993|GO:0035639|GO:0043412|GO:0050727|GO:0002237|GO:0001883|GO:0036211|GO:0071219|GO:0006954|GO:0032549|GO:0050729|GO:0016301|GO:0012501|GO:0006796|GO:0044267|GO:0071310|GO:0017076|GO:0043068|GO:0016773|GO:0032496|GO:0005634|GO:0043067|GO:0043065|GO:0005524|GO:0030554|GO:0016310|GO:0042981|GO:0004672|GO:0006464|GO:0071396|GO:0006915|GO:0071222|GO:0006468|GO:0004674|GO:0097472|GO:0004693 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|protein binding|transferase activity|regulation of cell cycle|cell cycle|regulation of cell death|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cell death|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|response to wounding|response to bacterium|cell death|nucleotide binding|protein metabolic process|response to organic substance|cytosol|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|regulation of inflammatory response|response to molecule of bacterial origin|purine nucleoside binding|protein modification process|cellular response to molecule of bacterial origin|inflammatory response|ribonucleoside binding|positive regulation of inflammatory response|kinase activity|programmed cell death|phosphate-containing compound metabolic process|cellular protein metabolic process|cellular response to organic substance|purine nucleotide binding|positive regulation of programmed cell death|phosphotransferase activity, alcohol group as acceptor|response to lipopolysaccharide|nucleus|regulation of programmed cell death|positive regulation of apoptotic process|ATP binding|adenyl nucleotide binding|phosphorylation|regulation of apoptotic process|protein kinase activity|cellular protein modification process|cellular response to lipid|apoptotic process|cellular response to lipopolysaccharide|protein phosphorylation|protein serine/threonine kinase activity|cyclin-dependent protein kinase activity|cyclin-dependent protein serine/threonine kinase activity - - - - 6:110609978-110815958 87 95 227 689 813 1048 0.760330880993378 0.754549557965094 1.78863981805145 5.3951031364391 5.82962730820397 8.58366756027902 1.10117341900331 6.60279933497403 -2.58403611126343 1.30959575407244e-15 6.39880059608488e-14 DOWN ENSG00000158528 PPP1R9A protein phosphatase 1 regulatory subunit 9A [Source:HGNC Symbol;Acc:HGNC:14946] GO:0032502|GO:0045202|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0044326|GO:0042995|GO:1900454|GO:0048523|GO:0031594|GO:0044877|GO:0050794|GO:0060076|GO:0043229|GO:1900272|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0030427|GO:0071944|GO:0023057|GO:0009893|GO:0031252|GO:0050793|GO:0005622|GO:0007269|GO:0005515|GO:0048856|GO:0019222|GO:0042802|GO:0060341|GO:0050804|GO:0042391|GO:0045595|GO:0048468|GO:0008022|GO:0043025|GO:0044325|GO:0006810|GO:0051130|GO:0005938|GO:0007275|GO:0032535|GO:0016358|GO:0032940|GO:0061669|GO:0031325|GO:0051128|GO:0030426|GO:0050806|GO:0022607|GO:0050803|GO:0045597|GO:0019899|GO:0005737|GO:0032970|GO:0007267|GO:0051963|GO:0032403|GO:0043005|GO:0030027|GO:0046983|GO:0043197|GO:0036477|GO:0014069|GO:0019904|GO:0032231|GO:0010646|GO:0043085|GO:0007154|GO:0060996|GO:0060491|GO:0007165|GO:0050808|GO:0051649|GO:0008092|GO:0001505|GO:1990761|GO:0050790|GO:0051048|GO:1903531|GO:0030030|GO:0046929|GO:0050805|GO:0048869|GO:0030029|GO:0019538|GO:0043254|GO:0051589|GO:0031323|GO:0006996|GO:0007568|GO:0009636|GO:0046928|GO:0051017|GO:0006836|GO:0032268|GO:0000902|GO:0060998|GO:0005829|GO:0031175|GO:0060292|GO:0031344|GO:0048167|GO:0030864|GO:0007416|GO:0007166|GO:0032956|GO:0060997|GO:0043412|GO:0007010|GO:0050807|GO:0044309|GO:0050773|GO:0010720|GO:0097061|GO:0048813|GO:0060078|GO:0003779|GO:0031346|GO:0000904|GO:0051347|GO:0036211|GO:0032232|GO:0060999|GO:0019902|GO:0051046|GO:1904049|GO:0050769|GO:0030031|GO:0097237|GO:0030425|GO:0051247|GO:0022604|GO:0030175|GO:0006461|GO:0030036|GO:0051015|GO:0019900|GO:0032270|GO:0060291|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0046903|GO:0051246|GO:0051020|GO:0030154|GO:0030832|GO:0048858|GO:1900006|GO:0005856|GO:0051492|GO:0042803|GO:0051960|GO:0051489|GO:0048666|GO:0030182|GO:0015629|GO:0010975|GO:0031401|GO:0034622|GO:0010769|GO:0051497|GO:0043623|GO:0016310|GO:0008064|GO:0019903|GO:0051494|GO:0051493|GO:0046847|GO:0048814|GO:1900271|GO:1900452|GO:0060079|GO:0031032|GO:0019901|GO:0022008|GO:0030038|GO:0048667|GO:0006464|GO:0030863|GO:0019932|GO:0007015|GO:0051823|GO:0050767|GO:0048812|GO:0010976|GO:0030833|GO:0061001|GO:0043549|GO:0033674|GO:0045666|GO:0051258|GO:0045859|GO:0045860|GO:0006468|GO:0048699|GO:0008157|GO:0042325|GO:0001932|GO:0043149|GO:0001934|GO:0019722|GO:0061572|GO:0045664|GO:0042327|GO:0007268|GO:0008154|GO:0030041 developmental process|synapse|signaling|cell|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|dendritic spine neck|cell projection|positive regulation of long term synaptic depression|negative regulation of cellular process|neuromuscular junction|macromolecular complex binding|regulation of cellular process|excitatory synapse|intracellular organelle|negative regulation of long-term synaptic potentiation|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell periphery|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|regulation of developmental process|intracellular|neurotransmitter secretion|protein binding|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cellular localization|modulation of synaptic transmission|regulation of membrane potential|regulation of cell differentiation|cell development|protein C-terminus binding|neuronal cell body|ion channel binding|transport|positive regulation of cellular component organization|cell cortex|multicellular organism development|regulation of cellular component size|dendrite development|secretion by cell|spontaneous neurotransmitter secretion|positive regulation of cellular metabolic process|regulation of cellular component organization|growth cone|positive regulation of synaptic transmission|cellular component assembly|regulation of synapse structure or activity|positive regulation of cell differentiation|enzyme binding|cytoplasm|regulation of actin filament-based process|cell-cell signaling|regulation of synapse assembly|protein complex binding|neuron projection|lamellipodium|protein dimerization activity|dendritic spine|somatodendritic compartment|postsynaptic density|protein domain specific binding|regulation of actin filament bundle assembly|regulation of cell communication|positive regulation of catalytic activity|cell communication|dendritic spine development|regulation of cell projection assembly|signal transduction|synapse organization|establishment of localization in cell|cytoskeletal protein binding|regulation of neurotransmitter levels|growth cone lamellipodium|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|cell projection organization|negative regulation of neurotransmitter secretion|negative regulation of synaptic transmission|cellular developmental process|actin filament-based process|protein metabolic process|regulation of protein complex assembly|negative regulation of neurotransmitter transport|regulation of cellular metabolic process|organelle organization|aging|response to toxic substance|regulation of neurotransmitter secretion|actin filament bundle assembly|neurotransmitter transport|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|cytosol|neuron projection development|long term synaptic depression|regulation of cell projection organization|regulation of synaptic plasticity|cortical actin cytoskeleton|synapse assembly|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|dendritic spine morphogenesis|macromolecule modification|cytoskeleton organization|regulation of synapse organization|neuron spine|regulation of dendrite development|positive regulation of cell development|dendritic spine organization|dendrite morphogenesis|regulation of postsynaptic membrane potential|actin binding|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|positive regulation of transferase activity|protein modification process|negative regulation of actin filament bundle assembly|positive regulation of dendritic spine development|phosphatase binding|regulation of secretion|negative regulation of spontaneous neurotransmitter secretion|positive regulation of neurogenesis|cell projection assembly|cellular response to toxic substance|dendrite|positive regulation of protein metabolic process|regulation of cell morphogenesis|filopodium|protein complex assembly|actin cytoskeleton organization|actin filament binding|kinase binding|positive regulation of cellular protein metabolic process|long-term synaptic potentiation|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|secretion|regulation of protein metabolic process|GTPase binding|cell differentiation|regulation of actin filament length|cell projection morphogenesis|positive regulation of dendrite development|cytoskeleton|regulation of stress fiber assembly|protein homodimerization activity|regulation of nervous system development|regulation of filopodium assembly|neuron development|neuron differentiation|actin cytoskeleton|regulation of neuron projection development|positive regulation of protein modification process|cellular macromolecular complex assembly|regulation of cell morphogenesis involved in differentiation|negative regulation of stress fiber assembly|cellular protein complex assembly|phosphorylation|regulation of actin polymerization or depolymerization|protein phosphatase binding|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|filopodium assembly|regulation of dendrite morphogenesis|regulation of long-term synaptic potentiation|regulation of long term synaptic depression|excitatory postsynaptic potential|actomyosin structure organization|protein kinase binding|neurogenesis|contractile actin filament bundle assembly|cell morphogenesis involved in neuron differentiation|cellular protein modification process|cortical cytoskeleton|second-messenger-mediated signaling|actin filament organization|regulation of synapse structural plasticity|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|regulation of actin filament polymerization|regulation of dendritic spine morphogenesis|regulation of kinase activity|positive regulation of kinase activity|positive regulation of neuron differentiation|protein polymerization|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|generation of neurons|protein phosphatase 1 binding|regulation of phosphorylation|regulation of protein phosphorylation|stress fiber assembly|positive regulation of protein phosphorylation|calcium-mediated signaling|actin filament bundle organization|regulation of neuron differentiation|positive regulation of phosphorylation|synaptic transmission|actin polymerization or depolymerization|actin filament polymerization - - - - 7:94907202-95296415 56 63 118 392 455 385 0.14059550338754 0.143749084494738 0.26710239185629 0.881790973739933 0.937262706885162 0.905880575836364 0.183815659912856 0.908311418820486 -2.30492733686737 1.33103500645801e-15 6.49292795470547e-14 DOWN ENSG00000138246 DNAJC13 DnaJ heat shock protein family (Hsp40) member C13 [Source:HGNC Symbol;Acc:HGNC:30343] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0050794|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0060341|GO:0006810|GO:0060627|GO:0031982|GO:0043231|GO:0005774|GO:0005737|GO:0045184|GO:0071203|GO:0008104|GO:0070062|GO:0001503|GO:0051649|GO:0010008|GO:0048869|GO:0016021|GO:0010256|GO:0005768|GO:0006996|GO:0016192|GO:0005769|GO:0032386|GO:0015031|GO:0005773|GO:0046907|GO:0001649|GO:2000641|GO:1902954|GO:0031901|GO:0030154|GO:0007032|GO:0000323|GO:0045022|GO:0016482|GO:0016197|GO:0005765|GO:0061502|GO:0005764 developmental process|macromolecular complex|cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|regulation of cellular process|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|regulation of cellular localization|transport|regulation of vesicle-mediated transport|vesicle|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|establishment of protein localization|WASH complex|protein localization|extracellular exosome|ossification|establishment of localization in cell|endosome membrane|cellular developmental process|integral component of membrane|endomembrane system organization|endosome|organelle organization|vesicle-mediated transport|early endosome|regulation of intracellular transport|protein transport|vacuole|intracellular transport|osteoblast differentiation|regulation of early endosome to late endosome transport|regulation of early endosome to recycling endosome transport|early endosome membrane|cell differentiation|endosome organization|lytic vacuole|early endosome to late endosome transport|cytosolic transport|endosomal transport|lysosomal membrane|early endosome to recycling endosome transport|lysosome - - - - 3:132417526-132539032 673 809 1241 3123 3438 3242 4.36551193084852 4.76923600696385 7.25781996360683 18.1505458356704 18.2975919849504 19.7088853214091 5.46418930047307 18.71900771401 -1.77642459025211 1.35905907304597e-15 6.61881722132374e-14 DOWN ENSG00000122545 SEPT7 septin 7 [Source:HGNC Symbol;Acc:HGNC:1717] GO:0032502|GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0036094|GO:1903561|GO:0030496|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0009986|GO:0045177|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0042802|GO:0007049|GO:0031105|GO:0008360|GO:0022402|GO:0016324|GO:0005930|GO:0005938|GO:0007275|GO:0043168|GO:0000776|GO:0001882|GO:0031982|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0070062|GO:0000166|GO:0030030|GO:0051301|GO:0048869|GO:0032154|GO:0006996|GO:0005730|GO:0000902|GO:0005829|GO:0035639|GO:1903047|GO:0001883|GO:0009790|GO:0032432|GO:0000278|GO:0032549|GO:0031981|GO:0016476|GO:0022604|GO:0005694|GO:0006461|GO:0042641|GO:0007067|GO:0032990|GO:0017076|GO:0048858|GO:0005856|GO:0000910|GO:0005634|GO:0005819|GO:0000777|GO:0045995|GO:0060271|GO:0015629|GO:0032561|GO:0051259|GO:0000793|GO:0001725|GO:0015630|GO:0005525|GO:0019001|GO:0000775|GO:0000779|GO:0051291 developmental process|macromolecular complex|structural molecule activity|cell|membrane|cellular process|extracellular region|binding|small molecule binding|extracellular vesicle|midbody|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|cell surface|apical part of cell|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|identical protein binding|cell cycle|septin complex|regulation of cell shape|cell cycle process|apical plasma membrane|axoneme|cell cortex|multicellular organism development|anion binding|kinetochore|nucleoside binding|vesicle|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|extracellular exosome|nucleotide binding|cell projection organization|cell division|cellular developmental process|cleavage furrow|organelle organization|nucleolus|cell morphogenesis|cytosol|purine ribonucleoside triphosphate binding|mitotic cell cycle process|purine nucleoside binding|embryo development|actin filament bundle|mitotic cell cycle|ribonucleoside binding|nuclear lumen|regulation of embryonic cell shape|regulation of cell morphogenesis|chromosome|protein complex assembly|actomyosin|mitotic nuclear division|cell part morphogenesis|purine nucleotide binding|cell projection morphogenesis|cytoskeleton|cytokinesis|nucleus|spindle|condensed chromosome kinetochore|regulation of embryonic development|cilium morphogenesis|actin cytoskeleton|guanyl ribonucleotide binding|protein oligomerization|condensed chromosome|stress fiber|microtubule cytoskeleton|GTP binding|guanyl nucleotide binding|chromosome, centromeric region|condensed chromosome, centromeric region|protein heterooligomerization - - - - 7:35800932-35907105 887 959 1226 3456 3591 3030 4.05556324395633 3.98497924942158 5.05396479202111 14.1578988439555 13.4713385306225 12.9837149176608 4.36483576179967 13.5376507640796 -1.63297812984521 1.38063410885916e-15 6.71293985112076e-14 DOWN ENSG00000114209 PDCD10 programmed cell death 10 [Source:HGNC Symbol;Acc:HGNC:8761] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0040013|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0042802|GO:0048514|GO:0047485|GO:0008284|GO:0051272|GO:0042127|GO:0051640|GO:0009888|GO:0001568|GO:0010941|GO:0007275|GO:0010632|GO:0031982|GO:0031325|GO:2000147|GO:0033554|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0009611|GO:0006928|GO:0051656|GO:0009966|GO:0048729|GO:0046983|GO:0050673|GO:0006979|GO:0060548|GO:0010646|GO:0043085|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0070062|GO:0031647|GO:0051649|GO:0008219|GO:0051271|GO:0008285|GO:0050790|GO:2000145|GO:0010035|GO:0009967|GO:0010633|GO:0019538|GO:0023014|GO:0031323|GO:2000146|GO:0010256|GO:0005794|GO:0006996|GO:0016525|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0002040|GO:0010468|GO:0090132|GO:0007166|GO:0002009|GO:0001944|GO:0043412|GO:0007030|GO:0072358|GO:0042542|GO:0010629|GO:0050821|GO:0051645|GO:0043069|GO:0010628|GO:0030334|GO:0044319|GO:0001935|GO:0001667|GO:0051347|GO:0036211|GO:0042060|GO:0031098|GO:0045765|GO:0045747|GO:0034599|GO:0051247|GO:0008593|GO:0050678|GO:0050680|GO:0030336|GO:0019900|GO:0032270|GO:0012501|GO:0060429|GO:0000302|GO:0006796|GO:1901342|GO:0035556|GO:0044267|GO:0051174|GO:0090168|GO:0010467|GO:0000139|GO:0010594|GO:0051683|GO:0051246|GO:0030335|GO:1902531|GO:0072359|GO:0010596|GO:0042803|GO:0043067|GO:0097190|GO:0070304|GO:0097193|GO:0031401|GO:0008631|GO:0043408|GO:0002011|GO:0043537|GO:0043535|GO:0016310|GO:0002043|GO:0002042|GO:0001936|GO:0043410|GO:0001937|GO:0010631|GO:0032872|GO:0042981|GO:0043066|GO:1903671|GO:0034614|GO:0007219|GO:0019901|GO:0006464|GO:0051403|GO:0043549|GO:0070301|GO:0006915|GO:0033674|GO:0045859|GO:0045860|GO:0043406|GO:0006468|GO:0043405|GO:0090051|GO:1903588|GO:0042325|GO:0001932|GO:0018193|GO:0036481|GO:0032874|GO:0001934|GO:0090049|GO:0043542|GO:0042327|GO:0033138|GO:0071902|GO:0018105|GO:0033135|GO:0071900|GO:0043534 locomotion|developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|protein N-terminus binding|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|organelle localization|tissue development|blood vessel development|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|vesicle|positive regulation of cellular metabolic process|positive regulation of cell motility|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|response to wounding|movement of cell or subcellular component|establishment of organelle localization|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|epithelial cell proliferation|response to oxidative stress|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|extracellular exosome|regulation of protein stability|establishment of localization in cell|cell death|negative regulation of cellular component movement|negative regulation of cell proliferation|regulation of catalytic activity|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|negative regulation of epithelial cell migration|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|negative regulation of cell motility|endomembrane system organization|Golgi apparatus|organelle organization|negative regulation of angiogenesis|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|sprouting angiogenesis|regulation of gene expression|epithelium migration|cell surface receptor signaling pathway|morphogenesis of an epithelium|vasculature development|macromolecule modification|Golgi organization|cardiovascular system development|response to hydrogen peroxide|negative regulation of gene expression|protein stabilization|Golgi localization|negative regulation of programmed cell death|positive regulation of gene expression|regulation of cell migration|wound healing, spreading of cells|endothelial cell proliferation|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|wound healing|stress-activated protein kinase signaling cascade|regulation of angiogenesis|positive regulation of Notch signaling pathway|cellular response to oxidative stress|positive regulation of protein metabolic process|regulation of Notch signaling pathway|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of cell migration|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|response to reactive oxygen species|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|Golgi reassembly|gene expression|Golgi membrane|regulation of endothelial cell migration|establishment of Golgi localization|regulation of protein metabolic process|positive regulation of cell migration|regulation of intracellular signal transduction|circulatory system development|negative regulation of endothelial cell migration|protein homodimerization activity|regulation of programmed cell death|apoptotic signaling pathway|positive regulation of stress-activated protein kinase signaling cascade|intrinsic apoptotic signaling pathway|positive regulation of protein modification process|intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of MAPK cascade|morphogenesis of an epithelial sheet|negative regulation of blood vessel endothelial cell migration|regulation of blood vessel endothelial cell migration|phosphorylation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cell migration involved in sprouting angiogenesis|regulation of endothelial cell proliferation|positive regulation of MAPK cascade|negative regulation of endothelial cell proliferation|epithelial cell migration|regulation of stress-activated MAPK cascade|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of sprouting angiogenesis|cellular response to reactive oxygen species|Notch signaling pathway|protein kinase binding|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|cellular response to hydrogen peroxide|apoptotic process|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|protein phosphorylation|regulation of MAP kinase activity|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|intrinsic apoptotic signaling pathway in response to hydrogen peroxide|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|regulation of cell migration involved in sprouting angiogenesis|endothelial cell migration|positive regulation of phosphorylation|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein serine/threonine kinase activity|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|regulation of protein serine/threonine kinase activity|blood vessel endothelial cell migration - - - - 3:167683298-167734939 331 371 475 1306 1363 1161 3.30751555890655 3.36920744398823 4.27939074620299 11.6926927960441 11.1747427382822 10.8726389572448 3.65203791636592 11.2466914971904 -1.62272700916874 1.52336449422218e-15 7.39488188788762e-14 DOWN ENSG00000100629 CEP128 centrosomal protein 128kDa [Source:HGNC Symbol;Acc:HGNC:20359] GO:0005623|GO:0043229|GO:0005622|GO:0005737|GO:0005813|GO:0005815|GO:0005814|GO:0005856|GO:0000922|GO:0005819|GO:0015630 cell|intracellular organelle|intracellular|cytoplasm|centrosome|microtubule organizing center|centriole|cytoskeleton|spindle pole|spindle|microtubule cytoskeleton - - - - 14:80476983-80959517 10 7 12 116 121 67 0.0533556332112583 0.0339474646761225 0.0577307553715442 0.554569090257573 0.529729820288309 0.335046320759623 0.048344617752975 0.473115077101835 -3.29076394969252 1.69522335783109e-15 8.21577891634569e-14 DOWN ENSG00000156026 MCU mitochondrial calcium uniporter [Source:HGNC Symbol;Acc:HGNC:23526] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0022857|GO:0050794|GO:0043229|GO:0051050|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0042802|GO:0060341|GO:0046887|GO:0019866|GO:0006810|GO:0032940|GO:0022607|GO:0043231|GO:0005737|GO:0007267|GO:0032880|GO:0051222|GO:0042592|GO:0031966|GO:0045184|GO:0046883|GO:0019725|GO:0022891|GO:0010646|GO:0008104|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0051649|GO:0051047|GO:0010817|GO:0016021|GO:0031301|GO:0005740|GO:0090276|GO:0002793|GO:1990246|GO:0048878|GO:0051223|GO:0015031|GO:0070201|GO:0015267|GO:0046907|GO:0042886|GO:0006811|GO:0055082|GO:0050714|GO:0015075|GO:0051046|GO:0005743|GO:0031304|GO:0009914|GO:0009306|GO:0034702|GO:0005739|GO:0006461|GO:0032592|GO:0035556|GO:0046903|GO:0034220|GO:0090277|GO:0050796|GO:0002790|GO:0036444|GO:0030073|GO:0098655|GO:0005216|GO:0015292|GO:0006839|GO:0034703|GO:0006812|GO:0050708|GO:0015833|GO:0031305|GO:0032024|GO:0050801|GO:0035786|GO:0019932|GO:0046879|GO:0006873|GO:0008324|GO:0033500|GO:0042593|GO:0030072|GO:0006851|GO:0034704|GO:0022890|GO:0030001|GO:0019722|GO:0005261|GO:0030003|GO:0005262|GO:0070588|GO:0055065|GO:0006875|GO:0046873|GO:0006874|GO:0006816|GO:0055074|GO:0015085|GO:0051560|GO:0070509|GO:0051561 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|transmembrane transporter activity|regulation of cellular process|intracellular organelle|positive regulation of transport|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|organelle membrane|identical protein binding|regulation of cellular localization|positive regulation of hormone secretion|organelle inner membrane|transport|secretion by cell|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|regulation of protein localization|positive regulation of protein transport|homeostatic process|mitochondrial membrane|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|substrate-specific transmembrane transporter activity|regulation of cell communication|protein localization|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|establishment of localization in cell|positive regulation of secretion|regulation of hormone levels|integral component of membrane|integral component of organelle membrane|mitochondrial envelope|regulation of peptide hormone secretion|positive regulation of peptide secretion|uniplex complex|chemical homeostasis|regulation of protein transport|protein transport|regulation of establishment of protein localization|channel activity|intracellular transport|amide transport|ion transport|cellular chemical homeostasis|positive regulation of protein secretion|ion transmembrane transporter activity|regulation of secretion|mitochondrial inner membrane|intrinsic component of mitochondrial inner membrane|hormone transport|protein secretion|ion channel complex|mitochondrion|protein complex assembly|integral component of mitochondrial membrane|intracellular signal transduction|secretion|ion transmembrane transport|positive regulation of peptide hormone secretion|regulation of insulin secretion|peptide secretion|calcium ion transmembrane import into mitochondrion|insulin secretion|cation transmembrane transport|ion channel activity|uniporter activity|mitochondrial transport|cation channel complex|cation transport|regulation of protein secretion|peptide transport|integral component of mitochondrial inner membrane|positive regulation of insulin secretion|ion homeostasis|protein complex oligomerization|second-messenger-mediated signaling|hormone secretion|cellular ion homeostasis|cation transmembrane transporter activity|carbohydrate homeostasis|glucose homeostasis|peptide hormone secretion|mitochondrial calcium ion transport|calcium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|calcium-mediated signaling|cation channel activity|cellular cation homeostasis|calcium channel activity|calcium ion transmembrane transport|metal ion homeostasis|cellular metal ion homeostasis|metal ion transmembrane transporter activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|calcium ion transmembrane transporter activity|mitochondrial calcium ion homeostasis|calcium ion import|positive regulation of mitochondrial calcium ion concentration - - - - 10:72692131-72887694 231 250 525 1529 1649 1404 1.70887001066079 1.68080166489933 3.50162896836427 10.134499651343 10.0088828704775 9.73404018938328 2.29710021464146 9.95914090373459 -2.1162074998286 1.92019322303595e-15 9.29099651223909e-14 DOWN ENSG00000115808 STRN striatin [Source:HGNC Symbol;Acc:HGNC:11424] GO:0032502|GO:0032991|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0060076|GO:0043229|GO:0005911|GO:0044297|GO:0016043|GO:0071944|GO:0008287|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0007626|GO:0048856|GO:0097060|GO:0042127|GO:0048468|GO:0043025|GO:0007275|GO:0005102|GO:0016358|GO:0045211|GO:0022607|GO:0019899|GO:0005737|GO:0032403|GO:0043005|GO:0043197|GO:0036477|GO:0014069|GO:0000159|GO:0019904|GO:0005516|GO:0007154|GO:0007165|GO:0008285|GO:0030030|GO:0048869|GO:0043296|GO:0031175|GO:0045216|GO:0007166|GO:0044309|GO:0051427|GO:0034329|GO:0019902|GO:0030425|GO:0007399|GO:0030154|GO:0005923|GO:0070016|GO:0048666|GO:0030182|GO:0016055|GO:0035257|GO:0019903|GO:0022008|GO:0007043|GO:0070830|GO:0035258|GO:0043297|GO:0048699|GO:0051721|GO:0030331 developmental process|macromolecular complex|synapse|behavior|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|excitatory synapse|intracellular organelle|cell-cell junction|cell body|cellular component organization|cell periphery|protein serine/threonine phosphatase complex|intracellular|protein binding|plasma membrane|protein complex|locomotory behavior|anatomical structure development|synaptic membrane|regulation of cell proliferation|cell development|neuronal cell body|multicellular organism development|receptor binding|dendrite development|postsynaptic membrane|cellular component assembly|enzyme binding|cytoplasm|protein complex binding|neuron projection|dendritic spine|somatodendritic compartment|postsynaptic density|protein phosphatase type 2A complex|protein domain specific binding|calmodulin binding|cell communication|signal transduction|negative regulation of cell proliferation|cell projection organization|cellular developmental process|apical junction complex|neuron projection development|cell-cell junction organization|cell surface receptor signaling pathway|neuron spine|hormone receptor binding|cell junction assembly|phosphatase binding|dendrite|nervous system development|cell differentiation|bicellular tight junction|armadillo repeat domain binding|neuron development|neuron differentiation|Wnt signaling pathway|nuclear hormone receptor binding|protein phosphatase binding|neurogenesis|cell-cell junction assembly|bicellular tight junction assembly|steroid hormone receptor binding|apical junction assembly|generation of neurons|protein phosphatase 2A binding|estrogen receptor binding - - - - 2:36843640-36966472 345 414 685 1698 1991 1886 2.68178448172776 2.92472570440115 4.80074698039103 11.8260475811339 12.6982437366001 13.7396308810677 3.46908572217331 12.7546407329339 -1.87839486670352 1.94220139979092e-15 9.38227841251751e-14 DOWN ENSG00000103888 CEMIP cell migration inducing protein, hyaluronan binding [Source:HGNC Symbol;Acc:HGNC:29213] GO:0040011|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0033218|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0048870|GO:0040017|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0016787|GO:0009058|GO:0005905|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:0051272|GO:0051282|GO:0042277|GO:0006810|GO:0051130|GO:0010524|GO:0050877|GO:0016798|GO:0044281|GO:0043270|GO:0031982|GO:0031325|GO:0051128|GO:2000147|GO:0030276|GO:0043231|GO:0005737|GO:0032880|GO:0012506|GO:0005975|GO:0051222|GO:0006928|GO:0042592|GO:0045184|GO:0019725|GO:0032388|GO:0043085|GO:0008104|GO:0055085|GO:0061024|GO:0051270|GO:0016477|GO:0005783|GO:0051649|GO:2000021|GO:0090316|GO:0050790|GO:0051238|GO:2000145|GO:0019538|GO:0005539|GO:0031323|GO:0032268|GO:0030214|GO:0090150|GO:0043412|GO:0031410|GO:0005540|GO:0048878|GO:0032386|GO:0051223|GO:0015031|GO:0051208|GO:0030334|GO:0034767|GO:0005048|GO:0016023|GO:0051347|GO:0036211|GO:0030665|GO:0070201|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0032050|GO:0007600|GO:0051279|GO:0072657|GO:0051247|GO:0031988|GO:0034765|GO:0043269|GO:0034613|GO:0032270|GO:0006796|GO:0004553|GO:0030659|GO:1901137|GO:0044267|GO:0051174|GO:0051281|GO:0051246|GO:0009059|GO:0010522|GO:0030335|GO:1903827|GO:0051928|GO:0090314|GO:0005634|GO:0034220|GO:0098655|GO:0046923|GO:0033157|GO:0031401|GO:0050954|GO:0090280|GO:0006812|GO:0016310|GO:0006605|GO:0060402|GO:0016482|GO:0006886|GO:0030135|GO:0006024|GO:0050801|GO:0030203|GO:1904427|GO:0006464|GO:0006612|GO:0043549|GO:0006873|GO:0090279|GO:0033674|GO:0030136|GO:1903533|GO:1903169|GO:0045859|GO:0045860|GO:0007605|GO:0006027|GO:0006468|GO:0042325|GO:0001932|GO:0018193|GO:0030001|GO:0001934|GO:0051924|GO:0004415|GO:0030213|GO:0030003|GO:0042327|GO:0070588|GO:0030212|GO:0055065|GO:0071902|GO:0097553|GO:0006875|GO:0071900|GO:0018107|GO:0010800|GO:1900020|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 locomotion|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|amide binding|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cell motility|positive regulation of locomotion|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|hydrolase activity|biosynthetic process|coated pit|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|positive regulation of cellular component movement|regulation of sequestering of calcium ion|peptide binding|transport|positive regulation of cellular component organization|positive regulation of calcium ion transport into cytosol|neurological system process|hydrolase activity, acting on glycosyl bonds|small molecule metabolic process|positive regulation of ion transport|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|clathrin binding|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|vesicle membrane|carbohydrate metabolic process|positive regulation of protein transport|movement of cell or subcellular component|homeostatic process|establishment of protein localization|cellular homeostasis|positive regulation of intracellular transport|positive regulation of catalytic activity|protein localization|transmembrane transport|membrane organization|regulation of cellular component movement|cell migration|endoplasmic reticulum|establishment of localization in cell|regulation of ion homeostasis|positive regulation of intracellular protein transport|regulation of catalytic activity|sequestering of metal ion|regulation of cell motility|protein metabolic process|glycosaminoglycan binding|regulation of cellular metabolic process|regulation of cellular protein metabolic process|hyaluronan catabolic process|establishment of protein localization to membrane|macromolecule modification|cytoplasmic vesicle|hyaluronic acid binding|chemical homeostasis|regulation of intracellular transport|regulation of protein transport|protein transport|sequestering of calcium ion|regulation of cell migration|positive regulation of ion transmembrane transport|signal sequence binding|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|protein modification process|clathrin-coated vesicle membrane|regulation of establishment of protein localization|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|clathrin heavy chain binding|sensory perception|regulation of release of sequestered calcium ion into cytosol|protein localization to membrane|positive regulation of protein metabolic process|membrane-bounded vesicle|regulation of ion transmembrane transport|regulation of ion transport|cellular protein localization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of release of sequestered calcium ion into cytosol|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|positive regulation of cell migration|regulation of cellular protein localization|positive regulation of calcium ion transport|positive regulation of protein targeting to membrane|nucleus|ion transmembrane transport|cation transmembrane transport|ER retention sequence binding|regulation of intracellular protein transport|positive regulation of protein modification process|sensory perception of mechanical stimulus|positive regulation of calcium ion import|cation transport|phosphorylation|protein targeting|calcium ion transport into cytosol|cytosolic transport|intracellular protein transport|coated vesicle|glycosaminoglycan biosynthetic process|ion homeostasis|glycosaminoglycan metabolic process|positive regulation of calcium ion transmembrane transport|cellular protein modification process|protein targeting to membrane|regulation of kinase activity|cellular ion homeostasis|regulation of calcium ion import|positive regulation of kinase activity|clathrin-coated vesicle|regulation of protein targeting|regulation of calcium ion transmembrane transport|regulation of protein kinase activity|positive regulation of protein kinase activity|sensory perception of sound|glycosaminoglycan catabolic process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|metal ion transport|positive regulation of protein phosphorylation|regulation of calcium ion transport|hyalurononglucosaminidase activity|hyaluronan biosynthetic process|cellular cation homeostasis|positive regulation of phosphorylation|calcium ion transmembrane transport|hyaluronan metabolic process|metal ion homeostasis|positive regulation of protein serine/threonine kinase activity|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein kinase C activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration - - - - 15:80779343-80951776 131 113 181 594 630 531 0.976348903421921 0.765408867305102 1.21626035652864 3.96659404532914 3.85249440219494 3.7090057265666 0.986006042418554 3.84269805803023 -1.96245122751974 2.03924777669188e-15 9.83517013333755e-14 DOWN ENSG00000055130 CUL1 cullin 1 [Source:HGNC Symbol;Acc:HGNC:2551] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0007623|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0016032|GO:0002757|GO:0051726|GO:0042127|GO:0007049|GO:0045087|GO:0022402|GO:0007275|GO:0048513|GO:0006952|GO:0031325|GO:0033554|GO:0045786|GO:0043231|GO:0019899|GO:0005737|GO:0002218|GO:0009887|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0008219|GO:0008285|GO:0019787|GO:0050790|GO:0000151|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0000165|GO:0032268|GO:0005829|GO:0045732|GO:0007166|GO:1903047|GO:0043412|GO:0002758|GO:0034097|GO:0030163|GO:0004842|GO:0031461|GO:0044770|GO:0044265|GO:0007050|GO:0051347|GO:0036211|GO:0000278|GO:0002429|GO:0031981|GO:0031098|GO:0051351|GO:0007346|GO:1990234|GO:0010564|GO:0051247|GO:0006508|GO:0005654|GO:0002764|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0042176|GO:0071310|GO:0051246|GO:0005634|GO:1990452|GO:0045089|GO:0097190|GO:0045088|GO:0044389|GO:0031625|GO:0044257|GO:0019005|GO:0097193|GO:0019221|GO:0031401|GO:0061630|GO:0010498|GO:0038061|GO:0000086|GO:1903364|GO:0044772|GO:0030162|GO:0045862|GO:0051439|GO:0016310|GO:0002768|GO:0002221|GO:1901990|GO:0051603|GO:0071345|GO:1901987|GO:0051438|GO:0034612|GO:0051443|GO:0007219|GO:0006464|GO:0050851|GO:0051403|GO:0006915|GO:0002223|GO:1903052|GO:0002224|GO:0019941|GO:0006468|GO:0071356|GO:0038093|GO:0000082|GO:0033209|GO:0050852|GO:0051437|GO:0043161|GO:0032446|GO:0006511|GO:0031146|GO:0031398|GO:0034166|GO:0034134|GO:0038124|GO:2000058|GO:0038095|GO:0002756|GO:0031396|GO:0034138|GO:0002755|GO:2000060|GO:0034146|GO:0034142|GO:0038123|GO:0034162|GO:0031145|GO:0042787|GO:0016567|GO:0035666|GO:0006513 developmental process|macromolecular complex|immune system process|signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|circadian rhythm|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|viral process|immune response-activating signal transduction|regulation of cell cycle|regulation of cell proliferation|cell cycle|innate immune response|cell cycle process|multicellular organism development|animal organ development|defense response|positive regulation of cellular metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|activation of innate immune response|organ morphogenesis|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|cell death|negative regulation of cell proliferation|ubiquitin-like protein transferase activity|regulation of catalytic activity|ubiquitin ligase complex|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|cytosol|positive regulation of protein catabolic process|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|innate immune response-activating signal transduction|response to cytokine|protein catabolic process|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|cell cycle phase transition|cellular macromolecule catabolic process|cell cycle arrest|positive regulation of transferase activity|protein modification process|mitotic cell cycle|immune response-activating cell surface receptor signaling pathway|nuclear lumen|stress-activated protein kinase signaling cascade|positive regulation of ligase activity|regulation of mitotic cell cycle|transferase complex|regulation of cell cycle process|positive regulation of protein metabolic process|proteolysis|nucleoplasm|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of protein catabolic process|cellular response to organic substance|regulation of protein metabolic process|nucleus|Parkin-FBXW7-Cul1 ubiquitin ligase complex|positive regulation of innate immune response|apoptotic signaling pathway|regulation of innate immune response|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|SCF ubiquitin ligase complex|intrinsic apoptotic signaling pathway|cytokine-mediated signaling pathway|positive regulation of protein modification process|ubiquitin protein ligase activity|proteasomal protein catabolic process|NIK/NF-kappaB signaling|G2/M transition of mitotic cell cycle|positive regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of proteolysis|positive regulation of proteolysis|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphorylation|immune response-regulating cell surface receptor signaling pathway|pattern recognition receptor signaling pathway|regulation of mitotic cell cycle phase transition|proteolysis involved in cellular protein catabolic process|cellular response to cytokine stimulus|regulation of cell cycle phase transition|regulation of ubiquitin-protein transferase activity|response to tumor necrosis factor|positive regulation of ubiquitin-protein transferase activity|Notch signaling pathway|cellular protein modification process|antigen receptor-mediated signaling pathway|stress-activated MAPK cascade|apoptotic process|stimulatory C-type lectin receptor signaling pathway|positive regulation of proteolysis involved in cellular protein catabolic process|toll-like receptor signaling pathway|modification-dependent protein catabolic process|protein phosphorylation|cellular response to tumor necrosis factor|Fc receptor signaling pathway|G1/S transition of mitotic cell cycle|tumor necrosis factor-mediated signaling pathway|T cell receptor signaling pathway|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Fc-epsilon receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of protein ubiquitination|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|TRIF-dependent toll-like receptor signaling pathway|protein monoubiquitination K03347 cullin 1[-] hsa05168|hsa04141|hsa04310|hsa04120|hsa04110|hsa04114|hsa04350|hsa04710 Herpes simplex infection - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human)|Circadian rhythm - Homo sapiens (human) 7:148697914-148801036 811 915 917 3397 3722 2449 12.1387226236547 12.4466721701909 12.3747295478263 45.5559625239844 45.7084317189847 34.3534002900757 12.320041447224 41.8725981776816 -1.76499932992388 2.07834750291249e-15 1.00075784438628e-13 DOWN ENSG00000157423 HYDIN HYDIN, axonemal central pair apparatus protein [Source:HGNC Symbol;Acc:HGNC:19368] GO:0032502|GO:0005623|GO:0009987|GO:0042995|GO:0009653|GO:0016043|GO:0048856|GO:0005929|GO:0048646|GO:0009888|GO:0048468|GO:0005930|GO:0007275|GO:0048513|GO:0007420|GO:0022607|GO:0060322|GO:0006928|GO:0060438|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:1990718|GO:0007010|GO:0007417|GO:0002064|GO:0060541|GO:0035082|GO:1990716|GO:0044782|GO:0030031|GO:0007018|GO:1904158|GO:0070925|GO:0060429|GO:0042384|GO:0021591|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0000226|GO:0060271|GO:0030855|GO:0001578|GO:0003341 developmental process|cell|cellular process|cell projection|anatomical structure morphogenesis|cellular component organization|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|tissue development|cell development|axoneme|multicellular organism development|animal organ development|brain development|cellular component assembly|head development|movement of cell or subcellular component|trachea development|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|axonemal central pair projection|cytoskeleton organization|central nervous system development|epithelial cell development|respiratory system development|axoneme assembly|axonemal central apparatus|cilium organization|cell projection assembly|microtubule-based movement|axonemal central apparatus assembly|organelle assembly|epithelium development|cilium assembly|ventricular system development|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|microtubule cytoskeleton organization|cilium morphogenesis|epithelial cell differentiation|microtubule bundle formation|cilium movement - - - - 16:70807378-71230722 15 25 48 196 217 213 0.0352949429411524 0.0534632751192405 0.101832205025897 0.413219289583371 0.418942750948199 0.469716808070454 0.0635301410287633 0.433959616200675 -2.77204766646715 2.08326232980708e-15 1.00150907558874e-13 DOWN ENSG00000185261 KIAA0825 KIAA0825 [Source:HGNC Symbol;Acc:HGNC:28532] - - - - - - 5:94152966-94618604 1 2 0 40 36 36 0.00602577430369668 0.0109481100270895 0 0.215869378922117 0.177907548659209 0.203216016740417 0.00565796144359539 0.198997648107248 -5.13632522440538 2.10563112391378e-15 1.01063523429778e-13 DOWN ENSG00000105738 SIPA1L3 signal-induced proliferation-associated 1 like 3 [Source:HGNC Symbol;Acc:HGNC:23801] GO:0032502|GO:0002376|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0009653|GO:0016043|GO:0009893|GO:0005615|GO:0030234|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0009888|GO:0048468|GO:0007275|GO:0048513|GO:0008047|GO:0007423|GO:0009966|GO:0010646|GO:0043085|GO:0007163|GO:0007154|GO:0007165|GO:0050790|GO:0048869|GO:0006996|GO:0000902|GO:0005096|GO:0001654|GO:0007010|GO:0030097|GO:0051345|GO:0002064|GO:0030695|GO:0000904|GO:0030010|GO:0060429|GO:0035556|GO:0030154|GO:1902531|GO:0030855|GO:0043087|GO:0003382|GO:0043547|GO:0002244|GO:0051056|GO:0007264|GO:0090162 developmental process|immune system process|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|positive regulation of metabolic process|extracellular space|enzyme regulator activity|immune system development|protein binding|anatomical structure development|regulation of metabolic process|tissue development|cell development|multicellular organism development|animal organ development|enzyme activator activity|sensory organ development|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|establishment or maintenance of cell polarity|cell communication|signal transduction|regulation of catalytic activity|cellular developmental process|organelle organization|cell morphogenesis|GTPase activator activity|eye development|cytoskeleton organization|hemopoiesis|positive regulation of hydrolase activity|epithelial cell development|GTPase regulator activity|cell morphogenesis involved in differentiation|establishment of cell polarity|epithelium development|intracellular signal transduction|cell differentiation|regulation of intracellular signal transduction|epithelial cell differentiation|regulation of GTPase activity|epithelial cell morphogenesis|positive regulation of GTPase activity|hematopoietic progenitor cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|establishment of epithelial cell polarity K17703 signal-induced proliferation-associated 1 like protein 3[-] hsa04015 Rap1 signaling pathway - Homo sapiens (human) 19:37907228-38208372 223 240 500 1264 1596 1422 1.22158650494487 1.19483872833398 2.4694668177892 6.20388017735098 7.17330780891818 7.30040863789845 1.62863068368935 6.89253220805587 -2.0813746154866 2.1916734732494e-15 1.05024429968519e-13 DOWN ENSG00000150477 KIAA1328 KIAA1328 [Source:HGNC Symbol;Acc:HGNC:29248] GO:0005488|GO:0005515 binding|protein binding - - - - 18:36829106-37232172 8 9 11 63 124 110 0.0295940852249004 0.0302607679184925 0.0366887295532127 0.208819278212461 0.376379885412177 0.381379044469652 0.0321811942322019 0.32219273603143 -3.32363419820822 2.19888660506038e-15 1.05201219082488e-13 DOWN ENSG00000160741 CRTC2 CREB regulated transcription coactivator 2 [Source:HGNC Symbol;Acc:HGNC:27301] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0016032|GO:0006725|GO:0006810|GO:1901360|GO:0016570|GO:0034641|GO:0044281|GO:0031982|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0005975|GO:0042592|GO:0003682|GO:0006139|GO:0070062|GO:0008134|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051090|GO:0051276|GO:0010468|GO:0034645|GO:1901998|GO:0043412|GO:0048878|GO:0051252|GO:0006325|GO:0008140|GO:0016573|GO:0010628|GO:0036211|GO:0051091|GO:0031981|GO:0005996|GO:0005654|GO:0006461|GO:0044267|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0016051|GO:0061647|GO:0019318|GO:0045893|GO:0051259|GO:0032774|GO:2001141|GO:0043966|GO:0043970|GO:0032793|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0033500|GO:0042593|GO:0045944|GO:0006366|GO:0019319|GO:0006357|GO:1903506|GO:0006006|GO:0018193|GO:0051260|GO:0051262|GO:0051289|GO:0006094|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393 cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|homeostatic process|chromatin binding|nucleobase-containing compound metabolic process|extracellular exosome|transcription factor binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|toxin transport|macromolecule modification|chemical homeostasis|regulation of RNA metabolic process|chromatin organization|cAMP response element binding protein binding|histone acetylation|positive regulation of gene expression|protein modification process|positive regulation of sequence-specific DNA binding transcription factor activity|nuclear lumen|monosaccharide metabolic process|nucleoplasm|protein complex assembly|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|carbohydrate biosynthetic process|histone H3-K9 modification|hexose metabolic process|positive regulation of transcription, DNA-templated|protein oligomerization|RNA biosynthetic process|regulation of RNA biosynthetic process|histone H3 acetylation|histone H3-K9 acetylation|positive regulation of CREB transcription factor activity|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|carbohydrate homeostasis|glucose homeostasis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|hexose biosynthetic process|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|glucose metabolic process|peptidyl-amino acid modification|protein homooligomerization|protein tetramerization|protein homotetramerization|gluconeogenesis|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation K16333 CREB-regulated transcription coactivator 2[-] hsa04151|hsa05166|hsa04152|hsa04931|hsa04922 PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human) 1:153947669-153958625 1629 1679 1580 533 598 628 15.5317843441093 14.5489327825916 13.5822508382547 4.55329186827498 4.67809877172368 5.61162775801816 14.5543226549852 4.94767279933894 1.55662569936656 2.43296662819324e-15 1.1621405714893e-13 UP ENSG00000122729 ACO1 aconitase 1 [Source:HGNC Symbol;Acc:HGNC:117] GO:0032502|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0009791|GO:0006810|GO:0006082|GO:0051536|GO:0007275|GO:0003676|GO:0034641|GO:0015980|GO:0044281|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0042592|GO:0019725|GO:0006099|GO:0005783|GO:0070062|GO:0007586|GO:0050892|GO:0006091|GO:0010035|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0055114|GO:0032268|GO:0005829|GO:0051539|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0003723|GO:0048878|GO:0010038|GO:0055082|GO:0016836|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0045333|GO:0051246|GO:0010039|GO:0009059|GO:0043043|GO:0009060|GO:0003994|GO:0010608|GO:0006412|GO:0006417|GO:0050801|GO:0019752|GO:0044822|GO:0010040|GO:0006873|GO:0072350|GO:0003729|GO:0030003|GO:0055065|GO:0006875|GO:0006101|GO:0030350|GO:0006879|GO:0055072 developmental process|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|post-embryonic development|transport|organic acid metabolic process|iron-sulfur cluster binding|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|homeostatic process|cellular homeostasis|tricarboxylic acid cycle|endoplasmic reticulum|extracellular exosome|digestion|intestinal absorption|generation of precursor metabolites and energy|response to inorganic substance|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|oxidation-reduction process|regulation of cellular protein metabolic process|cytosol|4 iron, 4 sulfur cluster binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|RNA binding|chemical homeostasis|response to metal ion|cellular chemical homeostasis|hydro-lyase activity|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|cellular respiration|regulation of protein metabolic process|response to iron ion|macromolecule biosynthetic process|peptide biosynthetic process|aerobic respiration|aconitate hydratase activity|posttranscriptional regulation of gene expression|translation|regulation of translation|ion homeostasis|carboxylic acid metabolic process|poly(A) RNA binding|response to iron(II) ion|cellular ion homeostasis|tricarboxylic acid metabolic process|mRNA binding|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|citrate metabolic process|iron-responsive element binding|cellular iron ion homeostasis|iron ion homeostasis K01681 aconitate hydratase[4.2.1.3] hsa01100|hsa01200|hsa01230|hsa00020|hsa00630|hsa01210 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Citrate cycle (TCA cycle) - Homo sapiens (human)|Glyoxylate and dicarboxylate metabolism - Homo sapiens (human)|2-Oxocarboxylic acid metabolism - Homo sapiens (human) 9:32384603-32454769 223 258 531 1501 1692 1437 1.67580437037641 1.762044399915 3.59771002947832 10.1063871022151 10.4324394441733 10.1205358499256 2.34518626658991 10.219787465438 -2.12359077519361 2.63744613185744e-15 1.25780058818645e-13 DOWN ENSG00000178502 KLHL11 kelch like family member 11 [Source:HGNC Symbol;Acc:HGNC:19008] GO:0005488|GO:0005515 binding|protein binding - - - - 17:41853545-41865431 283 353 319 82 100 86 8.40057033071327 9.52305835441435 8.53743095858102 2.18088021784486 2.43551134722246 2.39247976080058 8.82035321456955 2.33629044195597 1.91661679252684 2.71604269334529e-15 1.29321752100686e-13 UP ENSG00000120029 C10orf76 chromosome 10 open reading frame 76 [Source:HGNC Symbol;Acc:HGNC:25788] GO:0016020|GO:0005488|GO:0031224|GO:0016021 membrane|binding|intrinsic component of membrane|integral component of membrane - - - - 10:101845599-102056193 110 135 168 576 590 477 1.48719862940418 1.6587951462791 2.04786806996042 6.97747569868271 6.54482825920086 6.04400792874504 1.73128728188123 6.52210396220954 -1.91349229902496 2.81604274248093e-15 1.3386964973571e-13 DOWN ENSG00000130338 TULP4 tubby like protein 4 [Source:HGNC Symbol;Acc:HGNC:15530] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0042995|GO:0003700|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0008289|GO:0009058|GO:0005622|GO:0005515|GO:0005929|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0005543|GO:0046483|GO:0005737|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0044249|GO:0019538|GO:0031323|GO:0010468|GO:0034645|GO:0043412|GO:0035091|GO:0051252|GO:0036211|GO:0034613|GO:0035556|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0033365|GO:0032774|GO:2001141|GO:0006464|GO:0006351|GO:0006355|GO:1903506|GO:0061512|GO:0032446|GO:0016567 signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|cell projection|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|lipid binding|biosynthetic process|intracellular|protein binding|cilium|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|phospholipid binding|heterocycle metabolic process|cytoplasm|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|phosphatidylinositol binding|regulation of RNA metabolic process|protein modification process|cellular protein localization|intracellular signal transduction|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|protein localization to organelle|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|protein localization to cilium|protein modification by small protein conjugation|protein ubiquitination - - - - 6:158232236-158511828 71 111 131 416 492 467 0.284502060989116 0.404232762444603 0.473273165599693 1.4935442717654 1.61755997538818 1.75377111610868 0.387335996344471 1.62162512108742 -2.06578285645028 2.89935652349911e-15 1.37611112325187e-13 DOWN ENSG00000133706 LARS leucyl-tRNA synthetase [Source:HGNC Symbol;Acc:HGNC:6512] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0016788|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0006139|GO:0006450|GO:0000166|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0035639|GO:0001883|GO:0032549|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0051246|GO:0009059|GO:0016070|GO:0016876|GO:0005634|GO:0052689|GO:0043043|GO:0002161|GO:0043039|GO:0005524|GO:0034660|GO:0030554|GO:0010608|GO:0006412|GO:0006417|GO:0019752|GO:0004812|GO:0006414|GO:0006418|GO:0006399|GO:0004823|GO:0006429 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|ligase activity|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|regulation of translational fidelity|nucleotide binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|ligase activity, forming aminoacyl-tRNA and related compounds|nucleus|carboxylic ester hydrolase activity|peptide biosynthetic process|aminoacyl-tRNA editing activity|tRNA aminoacylation|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|posttranscriptional regulation of gene expression|translation|regulation of translation|carboxylic acid metabolic process|aminoacyl-tRNA ligase activity|translational elongation|tRNA aminoacylation for protein translation|tRNA metabolic process|leucine-tRNA ligase activity|leucyl-tRNA aminoacylation K01869 leucyl-tRNA synthetase[6.1.1.4] hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) 5:146113038-146182660 683 879 1144 3297 3465 2678 3.79612188539206 4.44005891423554 5.73271175692116 16.4186100495415 15.8012296915593 13.9495175150983 4.65629751884959 15.3897857520664 -1.72471799865176 2.93521285199637e-15 1.39091816640476e-13 DOWN ENSG00000013503 POLR3B polymerase (RNA) III (DNA directed) polypeptide B [Source:HGNC Symbol;Acc:HGNC:30348] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0043234|GO:0016740|GO:0045087|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0006952|GO:0001882|GO:0016772|GO:0046483|GO:0098542|GO:0001817|GO:0043231|GO:0043169|GO:0005737|GO:0001816|GO:0009615|GO:0001819|GO:0006139|GO:0050776|GO:0050778|GO:0051607|GO:0044249|GO:0005829|GO:0003677|GO:0034645|GO:0032479|GO:0046872|GO:0032481|GO:0032549|GO:0031981|GO:1990234|GO:0032606|GO:0005654|GO:0010467|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0045089|GO:0045088|GO:0032774|GO:0032728|GO:0032608|GO:0032648|GO:0006351|GO:0005666|GO:0003899|GO:0006383|GO:0006354|GO:0006353|GO:0001056|GO:0006385|GO:0006386 macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein complex|transferase activity|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|defense response to other organism|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|cytoplasm|cytokine production|response to virus|positive regulation of cytokine production|nucleobase-containing compound metabolic process|regulation of immune response|positive regulation of immune response|defense response to virus|cellular biosynthetic process|cytosol|DNA binding|cellular macromolecule biosynthetic process|regulation of type I interferon production|metal ion binding|positive regulation of type I interferon production|ribonucleoside binding|nuclear lumen|transferase complex|type I interferon production|nucleoplasm|gene expression|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|positive regulation of innate immune response|regulation of innate immune response|RNA biosynthetic process|positive regulation of interferon-beta production|interferon-beta production|regulation of interferon-beta production|transcription, DNA-templated|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase activity|transcription from RNA polymerase III promoter|DNA-templated transcription, elongation|DNA-templated transcription, termination|RNA polymerase III activity|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription K03021 DNA-directed RNA polymerase III subunit RPC2[2.7.7.6] hsa01100|hsa05169|hsa00230|hsa00240|hsa04623|hsa03020 Metabolic pathways - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Cytosolic DNA-sensing pathway - Homo sapiens (human)|RNA polymerase - Homo sapiens (human) 12:106357658-106510198 50 50 42 343 388 205 0.605618265292132 0.550404983553677 0.458666341696615 3.72241354190167 3.85596336257824 2.32710106240443 0.538229863514141 3.30182598896145 -2.61696974433388 3.18684781791373e-15 1.50776790421547e-13 DOWN ENSG00000184205 TSPYL2 TSPY-like 2 [Source:HGNC Symbol;Acc:HGNC:24358] GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0071704|GO:0044237|GO:0023051|GO:0045926|GO:0016043|GO:0043227|GO:0071944|GO:0040008|GO:0009058|GO:0005622|GO:0005886|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0045786|GO:0043231|GO:0030308|GO:0005737|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0050790|GO:0044249|GO:0019538|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0032268|GO:0003677|GO:0005813|GO:0010468|GO:0034645|GO:0051053|GO:0030968|GO:0043412|GO:0051252|GO:0006325|GO:0005815|GO:0036211|GO:0006986|GO:0031981|GO:0005654|GO:0006259|GO:0006461|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0051246|GO:0009059|GO:0035967|GO:0016070|GO:0034976|GO:0005856|GO:0005634|GO:0034620|GO:0008156|GO:0006260|GO:0006334|GO:0034622|GO:0036498|GO:0032774|GO:0043565|GO:2001141|GO:0034728|GO:0016310|GO:0003690|GO:0006333|GO:0015630|GO:0065004|GO:0006275|GO:0031497|GO:0016568|GO:0006464|GO:0071103|GO:0043549|GO:0006351|GO:0006355|GO:0006323|GO:0045859|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0000182 growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|organic substance metabolic process|cellular metabolic process|regulation of signaling|negative regulation of growth|cellular component organization|membrane-bounded organelle|cell periphery|regulation of growth|biosynthetic process|intracellular|plasma membrane|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|negative regulation of cell cycle|intracellular membrane-bounded organelle|negative regulation of cell growth|cytoplasm|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|regulation of cellular protein metabolic process|DNA binding|centrosome|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|endoplasmic reticulum unfolded protein response|macromolecule modification|regulation of RNA metabolic process|chromatin organization|microtubule organizing center|protein modification process|response to unfolded protein|nuclear lumen|nucleoplasm|DNA metabolic process|protein complex assembly|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|regulation of protein metabolic process|macromolecule biosynthetic process|cellular response to topologically incorrect protein|RNA metabolic process|response to endoplasmic reticulum stress|cytoskeleton|nucleus|cellular response to unfolded protein|negative regulation of DNA replication|DNA replication|nucleosome assembly|cellular macromolecular complex assembly|IRE1-mediated unfolded protein response|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nucleosome organization|phosphorylation|double-stranded DNA binding|chromatin assembly or disassembly|microtubule cytoskeleton|protein-DNA complex assembly|regulation of DNA replication|chromatin assembly|chromatin modification|cellular protein modification process|DNA conformation change|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA packaging|regulation of protein kinase activity|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|rDNA binding - - - - X:53082367-53088540 611 648 606 202 231 174 4.16259538864203 4.01215762270565 3.72228626453841 1.23302353838932 1.29122541048754 1.1109699072986 3.9656797586287 1.21173961872515 1.71048845738468 3.20565537241875e-15 1.5142663843068e-13 UP ENSG00000267041 ZNF850 zinc finger protein 850 [Source:HGNC Symbol;Acc:HGNC:27994] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:36714383-36772825 272 333 416 84 78 104 1.26084251475658 1.40286382811193 1.7385977815921 0.348872822040497 0.296655021344414 0.451806272626966 1.46743470815354 0.365778038670626 2.00425595035398 3.2645394602107e-15 1.53964551414108e-13 UP ENSG00000180357 ZNF609 zinc finger protein 609 [Source:HGNC Symbol;Acc:HGNC:29003] GO:0005623|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0043231|GO:0043169|GO:0046872|GO:0005634 cell|binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cation binding|metal ion binding|nucleus - - - - 15:64460742-64686068 236 258 406 1051 1119 1020 1.19703972373109 1.18931047873225 1.85667730009525 4.77635163439378 4.65687201898068 4.84869656498786 1.41434250085286 4.76064007278744 -1.75102402912228 3.35944857323193e-15 1.58159126703156e-13 DOWN ENSG00000237298 TTN-AS1 TTN antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44124] - - - - - - 2:178521183-178779963 34 61 57 252 283 247 0.0644584493496839 0.10510173272623 0.0974284101973109 0.428051616402926 0.440201613470248 0.438856777821023 0.0889961974244083 0.435703335898066 -2.29153055916717 3.36407333879895e-15 1.58159126703156e-13 DOWN ENSG00000196628 TCF4 transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:11634] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0045595|GO:0003712|GO:0006725|GO:0048468|GO:0008022|GO:1901360|GO:0001568|GO:0007275|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0090287|GO:0022607|GO:0045597|GO:0043231|GO:0000981|GO:0001076|GO:0005667|GO:0001775|GO:0009966|GO:0046983|GO:0009890|GO:0003682|GO:0010646|GO:0006139|GO:0001525|GO:0007154|GO:0007165|GO:0043621|GO:0008134|GO:0048869|GO:0044249|GO:0010033|GO:0001011|GO:0031324|GO:0031323|GO:0016525|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0007166|GO:0001944|GO:0072358|GO:0001085|GO:0010629|GO:0010720|GO:0046982|GO:0051252|GO:0043425|GO:0010628|GO:0050769|GO:0045765|GO:0070848|GO:1901342|GO:0010467|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0042118|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0042803|GO:1900746|GO:0051960|GO:0030182|GO:0000975|GO:0045893|GO:0034622|GO:0045892|GO:0032774|GO:0043565|GO:0001087|GO:2001141|GO:0001077|GO:0071363|GO:1902679|GO:0003690|GO:0007167|GO:0065004|GO:0022008|GO:0050767|GO:0006351|GO:0006355|GO:0045666|GO:0045944|GO:0006366|GO:1903507|GO:0006352|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0035924|GO:0000122|GO:0001093|GO:0045664|GO:0007169|GO:0006367|GO:0000976|GO:0001012|GO:0070888|GO:0001159|GO:0038084|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|protein C-terminus binding|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor activity, RNA polymerase II transcription factor binding|transcription factor complex|cell activation|regulation of signal transduction|protein dimerization activity|negative regulation of biosynthetic process|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|cell communication|signal transduction|protein self-association|transcription factor binding|cellular developmental process|cellular biosynthetic process|response to organic substance|transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of angiogenesis|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|cell surface receptor signaling pathway|vasculature development|cardiovascular system development|RNA polymerase II transcription factor binding|negative regulation of gene expression|positive regulation of cell development|protein heterodimerization activity|regulation of RNA metabolic process|bHLH transcription factor binding|positive regulation of gene expression|positive regulation of neurogenesis|regulation of angiogenesis|response to growth factor|regulation of vasculature development|gene expression|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|endothelial cell activation|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|regulation of vascular endothelial growth factor signaling pathway|regulation of nervous system development|neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|cellular macromolecular complex assembly|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|transcription factor activity, TFIIB-class binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cellular response to growth factor stimulus|negative regulation of RNA biosynthetic process|double-stranded DNA binding|enzyme linked receptor protein signaling pathway|protein-DNA complex assembly|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|cellular response to vascular endothelial growth factor stimulus|negative regulation of transcription from RNA polymerase II promoter|TFIIB-class transcription factor binding|regulation of neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|transcription initiation from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|E-box binding|core promoter proximal region DNA binding|vascular endothelial growth factor signaling pathway|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 18:55222331-55664787 3 4 22 167 213 111 0.00409773172666082 0.00496494136883899 0.0270895757259467 0.204356761245248 0.238683225751843 0.142077779906202 0.0120507496071488 0.195039255634431 -4.01656972900934 3.40514611522356e-15 1.59838415289126e-13 DOWN ENSG00000005156 LIG3 ligase III, DNA, ATP-dependent [Source:HGNC Symbol;Acc:HGNC:6600] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0007049|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0051128|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0009890|GO:0006139|GO:0000166|GO:0051301|GO:0070421|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0003677|GO:0034645|GO:0051053|GO:0046872|GO:0000725|GO:0035639|GO:0007005|GO:0001883|GO:0003909|GO:0006284|GO:0006302|GO:0032549|GO:0051103|GO:0043504|GO:0031981|GO:0005654|GO:0006259|GO:0005739|GO:0033043|GO:0017076|GO:0009059|GO:0006289|GO:0005634|GO:0006974|GO:0000002|GO:1901858|GO:0006303|GO:0000724|GO:0008156|GO:0006260|GO:0006297|GO:0005524|GO:0030554|GO:0010823|GO:0006283|GO:0070911|GO:0010821|GO:0006288|GO:0003910|GO:0006266|GO:0032042|GO:0006275|GO:0006310|GO:0046914|GO:0071897|GO:0006261|GO:0090298|GO:0097681|GO:0006264|GO:0008270 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|protein binding|protein complex|regulation of metabolic process|cell cycle|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|nucleotide binding|cell division|DNA ligase III-XRCC1 complex|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|DNA binding|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|metal ion binding|recombinational repair|purine ribonucleoside triphosphate binding|mitochondrion organization|purine nucleoside binding|DNA ligase activity|base-excision repair|double-strand break repair|ribonucleoside binding|DNA ligation involved in DNA repair|mitochondrial DNA repair|nuclear lumen|nucleoplasm|DNA metabolic process|mitochondrion|regulation of organelle organization|purine nucleotide binding|macromolecule biosynthetic process|nucleotide-excision repair|nucleus|cellular response to DNA damage stimulus|mitochondrial genome maintenance|regulation of mitochondrial DNA metabolic process|double-strand break repair via nonhomologous end joining|double-strand break repair via homologous recombination|negative regulation of DNA replication|DNA replication|nucleotide-excision repair, DNA gap filling|ATP binding|adenyl nucleotide binding|negative regulation of mitochondrion organization|transcription-coupled nucleotide-excision repair|global genome nucleotide-excision repair|regulation of mitochondrion organization|base-excision repair, DNA ligation|DNA ligase (ATP) activity|DNA ligation|mitochondrial DNA metabolic process|regulation of DNA replication|DNA recombination|transition metal ion binding|DNA biosynthetic process|DNA-dependent DNA replication|negative regulation of mitochondrial DNA replication|double-strand break repair via alternative nonhomologous end joining|mitochondrial DNA replication|zinc ion binding K10776 DNA ligase 3[6.5.1.1] hsa03410 Base excision repair - Homo sapiens (human) 17:34980494-35009743 64 87 95 335 386 340 0.257927689809096 0.318654609476807 0.34518847247057 1.20965407155031 1.27636495576784 1.28418266285553 0.307256923918824 1.25673389672456 -2.03216177638087 3.50760560941014e-15 1.64389415798007e-13 DOWN ENSG00000163808 KIF15 kinesin family member 15 [Source:HGNC Symbol;Acc:HGNC:17273] GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0044877|GO:0008283|GO:0019882|GO:0043229|GO:0006950|GO:0043167|GO:0016043|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0050817|GO:0019884|GO:0022402|GO:0003676|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0005737|GO:0009611|GO:0006928|GO:0032403|GO:0005875|GO:0008092|GO:0002504|GO:0048002|GO:0000166|GO:0007017|GO:0050878|GO:0006996|GO:0015631|GO:0005829|GO:0003677|GO:0005813|GO:0005871|GO:0035639|GO:1903047|GO:0007596|GO:0005815|GO:0001883|GO:0008017|GO:0016818|GO:0000278|GO:0042060|GO:0032549|GO:0007599|GO:0007018|GO:0007067|GO:0017076|GO:0005856|GO:0005819|GO:0002495|GO:0005873|GO:0005524|GO:0030554|GO:0019886|GO:0015630|GO:0016462|GO:0017111|GO:0016887|GO:0003774|GO:0003777 macromolecular complex|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|macromolecular complex binding|cell proliferation|antigen processing and presentation|intracellular organelle|response to stress|ion binding|cellular component organization|hydrolase activity|intracellular|protein binding|protein complex|cell cycle|coagulation|antigen processing and presentation of exogenous antigen|cell cycle process|nucleic acid binding|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|cytoplasm|response to wounding|movement of cell or subcellular component|protein complex binding|microtubule associated complex|cytoskeletal protein binding|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|antigen processing and presentation of peptide antigen|nucleotide binding|microtubule-based process|regulation of body fluid levels|organelle organization|tubulin binding|cytosol|DNA binding|centrosome|kinesin complex|purine ribonucleoside triphosphate binding|mitotic cell cycle process|blood coagulation|microtubule organizing center|purine nucleoside binding|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|wound healing|ribonucleoside binding|hemostasis|microtubule-based movement|mitotic nuclear division|purine nucleotide binding|cytoskeleton|spindle|antigen processing and presentation of peptide antigen via MHC class II|plus-end kinesin complex|ATP binding|adenyl nucleotide binding|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|motor activity|microtubule motor activity - - - - 3:44761717-44873376 116 163 205 620 692 591 1.17928871337748 1.50601619194398 1.87900740778682 5.64742485395007 5.77212321448545 5.63090136400683 1.52143743770276 5.68348314414745 -1.90134035118227 3.56621825827438e-15 1.66874419878563e-13 DOWN ENSG00000115760 BIRC6 baculoviral IAP repeat containing 6 [Source:HGNC Symbol;Acc:HGNC:13516] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0030496|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0044702|GO:0071704|GO:0044237|GO:0003006|GO:0023051|GO:0016043|GO:0043227|GO:0023057|GO:0030234|GO:0016874|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0001890|GO:0004857|GO:0009888|GO:0022402|GO:0010941|GO:0007275|GO:0048513|GO:0051302|GO:0043231|GO:0048608|GO:0005737|GO:0009966|GO:0048568|GO:0060548|GO:0010646|GO:0001892|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0008219|GO:0019787|GO:0050790|GO:0051301|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0060711|GO:0005794|GO:0005768|GO:0006996|GO:0032268|GO:0005802|GO:0007166|GO:1903047|GO:0043412|GO:0061458|GO:0004842|GO:0030414|GO:0043069|GO:2001234|GO:0060712|GO:0005815|GO:0009790|GO:0036211|GO:0032269|GO:0000278|GO:0032465|GO:0010564|GO:0051346|GO:0006508|GO:0012501|GO:0006796|GO:0044267|GO:0007067|GO:0051246|GO:0005856|GO:0000910|GO:0000922|GO:0005819|GO:0043067|GO:0097190|GO:2001237|GO:0004866|GO:0010466|GO:0009792|GO:0061631|GO:0030162|GO:2001236|GO:0016310|GO:0052547|GO:0015630|GO:0042981|GO:0045861|GO:0043066|GO:0006464|GO:0097191|GO:0006915|GO:0004869|GO:0006468|GO:0010951|GO:0043009|GO:0052548|GO:0032446|GO:0001701|GO:0016567 developmental process|reproduction|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|midbody|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|single organism reproductive process|organic substance metabolic process|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of signaling|enzyme regulator activity|ligase activity|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|placenta development|enzyme inhibitor activity|tissue development|cell cycle process|regulation of cell death|multicellular organism development|animal organ development|regulation of cell division|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|regulation of signal transduction|embryonic organ development|negative regulation of cell death|regulation of cell communication|embryonic placenta development|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|cell death|ubiquitin-like protein transferase activity|regulation of catalytic activity|cell division|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|labyrinthine layer development|Golgi apparatus|endosome|organelle organization|regulation of cellular protein metabolic process|trans-Golgi network|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|reproductive system development|ubiquitin-protein transferase activity|peptidase inhibitor activity|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|spongiotrophoblast layer development|microtubule organizing center|embryo development|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of cytokinesis|regulation of cell cycle process|negative regulation of hydrolase activity|proteolysis|programmed cell death|phosphate-containing compound metabolic process|cellular protein metabolic process|mitotic nuclear division|regulation of protein metabolic process|cytoskeleton|cytokinesis|spindle pole|spindle|regulation of programmed cell death|apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|endopeptidase inhibitor activity|negative regulation of peptidase activity|embryo development ending in birth or egg hatching|ubiquitin conjugating enzyme activity|regulation of proteolysis|regulation of extrinsic apoptotic signaling pathway|phosphorylation|regulation of peptidase activity|microtubule cytoskeleton|regulation of apoptotic process|negative regulation of proteolysis|negative regulation of apoptotic process|cellular protein modification process|extrinsic apoptotic signaling pathway|apoptotic process|cysteine-type endopeptidase inhibitor activity|protein phosphorylation|negative regulation of endopeptidase activity|chordate embryonic development|regulation of endopeptidase activity|protein modification by small protein conjugation|in utero embryonic development|protein ubiquitination K10586 baculoviral IAP repeat-containing protein 6 (apollon)[2.3.2.23] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 2:32357028-32618899 815 1080 1377 3326 3845 4191 2.6859176934022 3.23473476960076 4.09150553397645 9.82098391021223 10.3967920641681 12.9443936204559 3.33738599899314 11.0540565316121 -1.72778543371456 3.7378478186549e-15 1.74631782125388e-13 DOWN ENSG00000181031 RPH3AL rabphilin 3A-like (without C2 domains) [Source:HGNC Symbol;Acc:HGNC:10296] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0043167|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0060341|GO:0006810|GO:0060627|GO:0032940|GO:0031982|GO:0030276|GO:0030141|GO:0043231|GO:0043169|GO:0030133|GO:0019899|GO:0005737|GO:0032880|GO:0012506|GO:0051222|GO:0042592|GO:0009966|GO:0045184|GO:0030658|GO:0019904|GO:0042493|GO:0010646|GO:0000149|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0051649|GO:0008092|GO:0030667|GO:0051047|GO:0016192|GO:0007186|GO:0046872|GO:0031410|GO:0008277|GO:0048878|GO:0051223|GO:0015031|GO:0016023|GO:0006887|GO:0070201|GO:0046907|GO:0050714|GO:0017157|GO:0051046|GO:0009306|GO:0045744|GO:0031988|GO:0034613|GO:0030659|GO:0046903|GO:0051020|GO:0030274|GO:0019905|GO:0045055|GO:0050708|GO:0005509|GO:0006886|GO:0031267|GO:1903305|GO:0033500|GO:0042593|GO:0017016|GO:0017156|GO:0017158|GO:0017137 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|ion binding|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|intracellular|protein binding|endomembrane system|organelle membrane|regulation of cellular localization|transport|regulation of vesicle-mediated transport|secretion by cell|vesicle|clathrin binding|secretory granule|intracellular membrane-bounded organelle|cation binding|transport vesicle|enzyme binding|cytoplasm|regulation of protein localization|vesicle membrane|positive regulation of protein transport|homeostatic process|regulation of signal transduction|establishment of protein localization|transport vesicle membrane|protein domain specific binding|response to drug|regulation of cell communication|SNARE binding|protein localization|cell communication|signal transduction|negative regulation of signal transduction|establishment of localization in cell|cytoskeletal protein binding|secretory granule membrane|positive regulation of secretion|vesicle-mediated transport|G-protein coupled receptor signaling pathway|metal ion binding|cytoplasmic vesicle|regulation of G-protein coupled receptor protein signaling pathway|chemical homeostasis|regulation of protein transport|protein transport|cytoplasmic, membrane-bounded vesicle|exocytosis|regulation of establishment of protein localization|intracellular transport|positive regulation of protein secretion|regulation of exocytosis|regulation of secretion|protein secretion|negative regulation of G-protein coupled receptor protein signaling pathway|membrane-bounded vesicle|cellular protein localization|cytoplasmic vesicle membrane|secretion|GTPase binding|LIM domain binding|syntaxin binding|regulated exocytosis|regulation of protein secretion|calcium ion binding|intracellular protein transport|small GTPase binding|regulation of regulated secretory pathway|carbohydrate homeostasis|glucose homeostasis|Ras GTPase binding|calcium ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|Rab GTPase binding - - - - 17:212389-386254 71 97 137 417 479 452 0.489027739302908 0.607195591657995 0.850765287664233 2.57341284724318 2.7069381590726 2.91771122672832 0.648996206208379 2.7326874110147 -2.07403849116413 3.83128262764273e-15 1.78717361821322e-13 DOWN ENSG00000139946 PELI2 pellino E3 ubiquitin protein ligase family member 2 [Source:HGNC Symbol;Acc:HGNC:8828] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009893|GO:0016874|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0019222|GO:0002757|GO:0045087|GO:0006952|GO:0031325|GO:0005737|GO:0002218|GO:0009966|GO:0010646|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0007166|GO:0043412|GO:0002758|GO:0036211|GO:0051247|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:1902531|GO:0045089|GO:0045088|GO:0031401|GO:0043122|GO:0043408|GO:0016310|GO:0002221|GO:0008063|GO:0043123|GO:0007249|GO:0043410|GO:0006464|GO:0002224|GO:0006468|GO:0042325|GO:0001932|GO:0001934|GO:0042327|GO:0032446|GO:0034166|GO:0034134|GO:0038124|GO:0002755|GO:0034146|GO:0034142|GO:0038123|GO:0034162|GO:0016567 immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|positive regulation of metabolic process|ligase activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|regulation of metabolic process|immune response-activating signal transduction|innate immune response|defense response|positive regulation of cellular metabolic process|cytoplasm|activation of innate immune response|regulation of signal transduction|regulation of cell communication|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|cell surface receptor signaling pathway|macromolecule modification|innate immune response-activating signal transduction|protein modification process|positive regulation of protein metabolic process|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of intracellular signal transduction|positive regulation of innate immune response|regulation of innate immune response|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of MAPK cascade|phosphorylation|pattern recognition receptor signaling pathway|Toll signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|cellular protein modification process|toll-like receptor signaling pathway|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|protein modification by small protein conjugation|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|protein ubiquitination - - - - 14:56117814-56301526 56 97 130 455 447 602 0.620792713985886 0.977260417854194 1.2993177424403 4.51924370848191 4.06567078982313 6.25435282975471 0.965790291426793 4.94642244268658 -2.35660359040266 3.96610282712793e-15 1.84429959191709e-13 DOWN ENSG00000167513 CDT1 chromatin licensing and DNA replication factor 1 [Source:HGNC Symbol;Acc:HGNC:24576] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0005829|GO:0003677|GO:0010468|GO:0000075|GO:0034645|GO:1903047|GO:0051252|GO:0044770|GO:0033260|GO:0000278|GO:0031981|GO:0010564|GO:0005654|GO:0006259|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000083|GO:0006270|GO:0033262|GO:0006260|GO:0032774|GO:0044772|GO:2001141|GO:0006275|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:0006261|GO:1903506|GO:0000082|GO:0030174|GO:0000076 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|cytosol|DNA binding|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|mitotic cell cycle process|regulation of RNA metabolic process|cell cycle phase transition|nuclear DNA replication|mitotic cell cycle|nuclear lumen|regulation of cell cycle process|nucleoplasm|DNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulation of transcription involved in G1/S transition of mitotic cell cycle|DNA replication initiation|regulation of nuclear cell cycle DNA replication|DNA replication|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|regulation of DNA replication|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication|regulation of nucleic acid-templated transcription|G1/S transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|DNA replication checkpoint - - - - 16:88803213-88809258 2438 2723 3226 973 1244 919 45.2522813021367 45.9340164087933 53.9865273873258 16.1814446981261 18.9450280954884 15.9864119158138 48.3909416994186 17.0376282364761 1.50601249893211 3.96603989697554e-15 1.84429959191709e-13 UP ENSG00000155974 GRIP1 glutamate receptor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:18708] GO:0032502|GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0032947|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0097060|GO:0019222|GO:0003712|GO:0006725|GO:0008013|GO:0048468|GO:0008022|GO:1901360|GO:0030159|GO:0007275|GO:0005102|GO:0016358|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0045211|GO:0043231|GO:0005737|GO:0007267|GO:0043005|GO:0036477|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0009725|GO:0030030|GO:0048869|GO:0044249|GO:0010033|GO:0098857|GO:0031323|GO:0005768|GO:0003713|GO:0005829|GO:0031175|GO:0010468|GO:0034645|GO:0033993|GO:0031410|GO:0051427|GO:0051252|GO:0010628|GO:0016023|GO:0055037|GO:0030425|GO:0031988|GO:0014070|GO:0035556|GO:0010467|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0009755|GO:0045121|GO:0016070|GO:0032870|GO:0010557|GO:0048545|GO:0030522|GO:0048666|GO:0030182|GO:0043401|GO:0045893|GO:0032774|GO:2001141|GO:0035257|GO:0071383|GO:0071407|GO:0030518|GO:0022008|GO:0071396|GO:0006351|GO:0006355|GO:0035258|GO:0048699|GO:1903506|GO:0030521|GO:0007268|GO:0050681|GO:0035259 developmental process|synapse|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|protein complex scaffold|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|synaptic membrane|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|beta-catenin binding|cell development|protein C-terminus binding|organic cyclic compound metabolic process|receptor signaling complex scaffold activity|multicellular organism development|receptor binding|dendrite development|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|postsynaptic membrane|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|neuron projection|somatodendritic compartment|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|endoplasmic reticulum|response to hormone|cell projection organization|cellular developmental process|cellular biosynthetic process|response to organic substance|membrane microdomain|regulation of cellular metabolic process|endosome|transcription coactivator activity|cytosol|neuron projection development|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|cytoplasmic vesicle|hormone receptor binding|regulation of RNA metabolic process|positive regulation of gene expression|cytoplasmic, membrane-bounded vesicle|recycling endosome|dendrite|membrane-bounded vesicle|response to organic cyclic compound|intracellular signal transduction|gene expression|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|membrane raft|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to steroid hormone|intracellular receptor signaling pathway|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|neurogenesis|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|steroid hormone receptor binding|generation of neurons|regulation of nucleic acid-templated transcription|androgen receptor signaling pathway|synaptic transmission|androgen receptor binding|glucocorticoid receptor binding - - - - 12:66347431-66804186 4 2 5 68 59 43 0.0303154668158856 0.0137763424577455 0.034164457924215 0.461777535716347 0.366899967186699 0.305436583627332 0.026085422399282 0.378038028843459 -3.85721566994637 4.17150912154347e-15 1.93679989602735e-13 DOWN ENSG00000167123 CERCAM cerebral endothelial cell adhesion molecule [Source:HGNC Symbol;Acc:HGNC:23723] GO:0005623|GO:0016020|GO:0009987|GO:0043229|GO:0007155|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0012505|GO:0016337|GO:0098609|GO:0043231|GO:0005737|GO:0006928|GO:0005783|GO:0007159|GO:0005788 cell|membrane|cellular process|intracellular organelle|cell adhesion|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|endomembrane system|single organismal cell-cell adhesion|cell-cell adhesion|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|endoplasmic reticulum|leukocyte cell-cell adhesion|endoplasmic reticulum lumen - - - - 9:128411751-128437351 89 79 245 814 925 1347 0.568501469808265 0.458617237574892 1.41097967084121 4.65868546417177 4.84786843934456 8.0637629751761 0.812699459408122 5.85677229289748 -2.84931196486887 4.3715064416581e-15 2.02650548616865e-13 DOWN ENSG00000196693 ZNF33B zinc finger protein 33B [Source:HGNC Symbol;Acc:HGNC:13097] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 10:42574185-42638568 130 163 170 560 583 578 0.976506397892625 1.11275997276693 1.15132227312587 3.76893482147166 3.59310536509453 4.06901942947312 1.08019621459514 3.81035320534644 -1.81863133861962 4.42819081617194e-15 2.04960013373639e-13 DOWN ENSG00000145982 FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:21062] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0006082|GO:0003676|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006520|GO:0006139|GO:0000166|GO:0044249|GO:0019538|GO:0034645|GO:0006518|GO:0046872|GO:0003723|GO:0035639|GO:0001883|GO:0032549|GO:0005759|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0016070|GO:0016876|GO:0043043|GO:0000049|GO:0043039|GO:0006396|GO:0000287|GO:0005524|GO:0034660|GO:0030554|GO:0006412|GO:0019752|GO:0004812|GO:0006418|GO:0004826|GO:0006399|GO:0008033|GO:0006432 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|mitochondrial matrix|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|ligase activity, forming aminoacyl-tRNA and related compounds|peptide biosynthetic process|tRNA binding|tRNA aminoacylation|RNA processing|magnesium ion binding|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|translation|carboxylic acid metabolic process|aminoacyl-tRNA ligase activity|tRNA aminoacylation for protein translation|phenylalanine-tRNA ligase activity|tRNA metabolic process|tRNA processing|phenylalanyl-tRNA aminoacylation K01889 phenylalanyl-tRNA synthetase alpha chain[6.1.1.20] hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) 6:5261044-5771580 37 32 76 287 308 274 0.927770726871838 0.729242703484659 1.71818449310271 6.44796014716311 6.33666925082326 6.43904671021184 1.1250659744864 6.40789203606607 -2.50984023622465 4.46605628863417e-15 2.06392638453382e-13 DOWN ENSG00000112365 ZBTB24 zinc finger and BTB domain containing 24 [Source:HGNC Symbol;Acc:HGNC:21143] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0030097|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0002244|GO:0006351|GO:0006355|GO:1903506 developmental process|immune system process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|immune system development|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|hemopoiesis|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|hematopoietic progenitor cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 6:109462594-109483237 807 857 637 206 238 254 10.3432993055988 9.98266156110458 7.36104086291422 2.3656471841862 2.50281965322264 3.05104091836428 9.2290005765392 2.63983591859104 1.80572616419627 4.8961096959781e-15 2.25917247084591e-13 UP ENSG00000152749 GPR180 G protein-coupled receptor 180 [Source:HGNC Symbol;Acc:HGNC:28899] GO:0023052|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:1903561|GO:0051716|GO:0050794|GO:0043227|GO:0031224|GO:0031982|GO:0007154|GO:0007165|GO:0070062|GO:0016021|GO:0010033|GO:0007186|GO:0019236 signaling|membrane|cellular process|extracellular region|response to stimulus|extracellular vesicle|cellular response to stimulus|regulation of cellular process|membrane-bounded organelle|intrinsic component of membrane|vesicle|cell communication|signal transduction|extracellular exosome|integral component of membrane|response to organic substance|G-protein coupled receptor signaling pathway|response to pheromone - - - - 13:94601903-94634645 136 144 225 617 743 617 1.09048156739886 1.04935065737769 1.62658066009011 4.43263110803334 4.8880502452409 4.6365282952654 1.25547096162222 4.65240321617988 -1.88974747802628 5.06706999046986e-15 2.33444918974517e-13 DOWN ENSG00000167962 ZNF598 zinc finger protein 598 [Source:HGNC Symbol;Acc:HGNC:28079] GO:0005488|GO:0097159|GO:0043167|GO:0005515|GO:0003676|GO:0043169|GO:0046872|GO:0003723|GO:0046914|GO:0044822|GO:0008270 binding|organic cyclic compound binding|ion binding|protein binding|nucleic acid binding|cation binding|metal ion binding|RNA binding|transition metal ion binding|poly(A) RNA binding|zinc ion binding - - - - 16:1997654-2009823 2907 3269 2897 1095 1272 1018 15.6612370295074 16.0057474728407 14.0716103676456 5.28558212412371 5.62258758477387 5.13993532403391 15.2461982899979 5.3493683443105 1.51100909220485 5.13996363841586e-15 2.3643832736713e-13 UP ENSG00000099204 ABLIM1 actin binding LIM protein 1 [Source:HGNC Symbol;Acc:HGNC:78] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0042995|GO:0043229|GO:0043167|GO:0009653|GO:0016043|GO:0009605|GO:0031252|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0006935|GO:0048468|GO:0007275|GO:0048513|GO:0050877|GO:0022607|GO:0043169|GO:0005737|GO:0006928|GO:0009887|GO:0030027|GO:0008092|GO:0030030|GO:0048869|GO:0006996|GO:0000902|GO:0031175|GO:0046872|GO:0007010|GO:0003779|GO:0000904|GO:0044782|GO:0032432|GO:0007600|GO:0030031|GO:0042641|GO:0070925|GO:0097581|GO:0042384|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0005856|GO:0048666|GO:0030182|GO:0060271|GO:0015629|GO:0007411|GO:0050953|GO:0030032|GO:0061564|GO:0001725|GO:0046914|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699|GO:0007601|GO:0008270 locomotion|developmental process|cell|cellular process|response to stimulus|binding|cell projection|intracellular organelle|ion binding|anatomical structure morphogenesis|cellular component organization|response to external stimulus|cell leading edge|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|chemotaxis|cell development|multicellular organism development|animal organ development|neurological system process|cellular component assembly|cation binding|cytoplasm|movement of cell or subcellular component|organ morphogenesis|lamellipodium|cytoskeletal protein binding|cell projection organization|cellular developmental process|organelle organization|cell morphogenesis|neuron projection development|metal ion binding|cytoskeleton organization|actin binding|cell morphogenesis involved in differentiation|cilium organization|actin filament bundle|sensory perception|cell projection assembly|actomyosin|organelle assembly|lamellipodium organization|cilium assembly|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|cytoskeleton|neuron development|neuron differentiation|cilium morphogenesis|actin cytoskeleton|axon guidance|sensory perception of light stimulus|lamellipodium assembly|axon development|stress fiber|transition metal ion binding|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons|visual perception|zinc ion binding K07520 actin-binding LIM protein[-] hsa04360 Axon guidance - Homo sapiens (human) 10:114431113-114685003 152 66 138 705 720 657 0.749793002490395 0.295882980280236 0.613749716212361 3.11589918478629 2.91405203923044 3.03732461783069 0.553141899660997 3.02242528061581 -2.44998514082267 5.16304455901265e-15 2.37134665022713e-13 DOWN ENSG00000163660 CCNL1 cyclin L1 [Source:HGNC Symbol;Acc:HGNC:20569] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0019899|GO:0045787|GO:0006139|GO:0043085|GO:0000307|GO:0050790|GO:0019207|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0043412|GO:0019887|GO:0051252|GO:0010628|GO:0051347|GO:0036211|GO:0045737|GO:0031981|GO:1990234|GO:0051247|GO:0005654|GO:0019900|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:1904031|GO:0031401|GO:0006396|GO:0032774|GO:2001141|GO:0016310|GO:0016604|GO:0016538|GO:0019901|GO:0006464|GO:0000079|GO:0043549|GO:0006351|GO:0006355|GO:0033674|GO:0016607|GO:0045944|GO:0006366|GO:0045859|GO:0045860|GO:0006357|GO:1902911|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0001934|GO:0042327|GO:0070816|GO:1901409|GO:1902554|GO:0071902|GO:1901407|GO:0071900 macromolecular complex|cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|positive regulation of cell cycle|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cyclin-dependent protein kinase holoenzyme complex|regulation of catalytic activity|kinase regulator activity|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|protein kinase regulator activity|regulation of RNA metabolic process|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|positive regulation of cyclin-dependent protein serine/threonine kinase activity|nuclear lumen|transferase complex|positive regulation of protein metabolic process|nucleoplasm|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein modification process|RNA processing|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorylation|nuclear body|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|cellular protein modification process|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of kinase activity|nuclear speck|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein kinase complex|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of phosphorylation of RNA polymerase II C-terminal domain|serine/threonine protein kinase complex|positive regulation of protein serine/threonine kinase activity|regulation of phosphorylation of RNA polymerase II C-terminal domain|regulation of protein serine/threonine kinase activity - - - - 3:157146508-157160760 3091 3272 3184 1124 1301 1244 8.67133111752663 8.34219141976181 8.05330336853423 2.82521142003714 2.99455296492132 3.27066560429071 8.35560863527422 3.03014332974972 1.4633588835428 5.43041323514124e-15 2.49031577145786e-13 UP ENSG00000185404 SP140L SP140 nuclear body protein like [Source:HGNC Symbol;Acc:HGNC:25105] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0043169|GO:0003677|GO:0046872|GO:0005634|GO:0046914|GO:0008270 cell|binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|DNA binding|metal ion binding|nucleus|transition metal ion binding|zinc ion binding - - - - 2:230327184-230403732 80 80 101 390 400 325 0.65376040661377 0.594152514593988 0.744156236227324 2.85555672133883 2.68198869705689 2.4890881335806 0.664023052478361 2.67554451732544 -2.01052730086302 5.44540758751715e-15 2.49336193432112e-13 DOWN ENSG00000169169 CPT1C carnitine palmitoyltransferase 1C [Source:HGNC Symbol;Acc:HGNC:18540] GO:0032991|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0003824|GO:0042995|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0019867|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0006082|GO:0098797|GO:0034641|GO:0044281|GO:0005887|GO:0043231|GO:0016746|GO:0005737|GO:0043235|GO:0043005|GO:0031966|GO:0036477|GO:0031226|GO:1902495|GO:0006629|GO:0005783|GO:0016021|GO:0055114|GO:0005740|GO:0008328|GO:0030424|GO:0016042|GO:0005741|GO:0044242|GO:0006631|GO:0006577|GO:0034440|GO:0030425|GO:0009437|GO:0034702|GO:0005739|GO:0016747|GO:0030258|GO:0016409|GO:0046395|GO:0032281|GO:0019752|GO:0009062|GO:0019395|GO:0008374|GO:0006635|GO:0032787|GO:0004095 macromolecular complex|synapse|cell|membrane|cellular process|metabolic process|cell junction|binding|catalytic activity|cell projection|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|outer membrane|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|organic acid metabolic process|plasma membrane protein complex|cellular nitrogen compound metabolic process|small molecule metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|receptor complex|neuron projection|mitochondrial membrane|somatodendritic compartment|intrinsic component of plasma membrane|transmembrane transporter complex|lipid metabolic process|endoplasmic reticulum|integral component of membrane|oxidation-reduction process|mitochondrial envelope|ionotropic glutamate receptor complex|axon|lipid catabolic process|mitochondrial outer membrane|cellular lipid catabolic process|fatty acid metabolic process|amino-acid betaine metabolic process|lipid oxidation|dendrite|carnitine metabolic process|ion channel complex|mitochondrion|transferase activity, transferring acyl groups other than amino-acyl groups|lipid modification|palmitoyltransferase activity|carboxylic acid catabolic process|AMPA glutamate receptor complex|carboxylic acid metabolic process|fatty acid catabolic process|fatty acid oxidation|O-acyltransferase activity|fatty acid beta-oxidation|monocarboxylic acid metabolic process|carnitine O-palmitoyltransferase activity K19524 carnitine O-palmitoyltransferase 1, brain isoform[2.3.1.21] hsa04152|hsa04922|hsa04920|hsa03320|hsa01212|hsa00071 AMPK signaling pathway - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Fatty acid metabolism - Homo sapiens (human)|Fatty acid degradation - Homo sapiens (human) 19:49690898-49713731 116 86 69 13 7 9 0.63692392049061 0.429147557152835 0.341580801462596 0.0639539722722059 0.0315352192069912 0.0463123670845195 0.46921742636868 0.0472671861879055 3.31134570609181 5.5213500671107e-15 2.52426316850724e-13 UP ENSG00000047579 DTNBP1 dystrobrevin binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17328] GO:0032502|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0030672|GO:0008021|GO:0050794|GO:0060076|GO:0043229|GO:0051050|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0030427|GO:0043473|GO:0043227|GO:0071944|GO:0009893|GO:0005622|GO:0007269|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0097060|GO:0031090|GO:0019222|GO:0060341|GO:0050817|GO:0050804|GO:0033162|GO:0051640|GO:0048468|GO:0006810|GO:0007275|GO:0032940|GO:0001956|GO:0031982|GO:0030426|GO:0033554|GO:0045211|GO:0050806|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0009611|GO:0012506|GO:0006928|GO:0051656|GO:0043005|GO:0009966|GO:0042383|GO:0043197|GO:0036477|GO:0030658|GO:0014069|GO:0033059|GO:0010646|GO:0007154|GO:0061024|GO:0010970|GO:0007165|GO:0005783|GO:0051649|GO:0001505|GO:0010008|GO:0051047|GO:0050790|GO:0030030|GO:0048869|GO:0030029|GO:0007017|GO:0019538|GO:0023014|GO:0031323|GO:0010256|GO:0050878|GO:0005768|GO:0006996|GO:0046928|GO:0000165|GO:0016192|GO:0006836|GO:0051650|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007186|GO:0010468|GO:0016528|GO:0016050|GO:0033363|GO:0030424|GO:0043412|GO:0007010|GO:0050432|GO:0044309|GO:0031410|GO:0015844|GO:0008277|GO:0007596|GO:0048489|GO:0010628|GO:0016023|GO:0036211|GO:0070382|GO:0042060|GO:0046907|GO:0006811|GO:0051046|GO:0008088|GO:0048753|GO:0031098|GO:0007599|GO:0030425|GO:0007018|GO:0031988|GO:0030036|GO:0043269|GO:0006796|GO:0035556|GO:0030659|GO:0031083|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0007399|GO:0046903|GO:0051648|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0072384|GO:0005634|GO:0015837|GO:0048666|GO:0030182|GO:0060159|GO:0006820|GO:0032438|GO:0031532|GO:0043408|GO:0047496|GO:0006812|GO:0015696|GO:0008089|GO:0016310|GO:0048193|GO:0016482|GO:0032872|GO:0044070|GO:0060155|GO:0022008|GO:0006464|GO:0030705|GO:0048812|GO:0051403|GO:0043549|GO:0007212|GO:0045859|GO:0046328|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0042470|GO:0014059|GO:0048490|GO:0006892|GO:0015872|GO:0015672|GO:0007268|GO:0071900|GO:0043506 developmental process|macromolecular complex|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|synaptic vesicle membrane|synaptic vesicle|regulation of cellular process|excitatory synapse|intracellular organelle|positive regulation of transport|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|site of polarized growth|pigmentation|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|intracellular|neurotransmitter secretion|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|synaptic membrane|organelle membrane|regulation of metabolic process|regulation of cellular localization|coagulation|modulation of synaptic transmission|melanosome membrane|organelle localization|cell development|transport|multicellular organism development|secretion by cell|positive regulation of neurotransmitter secretion|vesicle|growth cone|cellular response to stress|postsynaptic membrane|positive regulation of synaptic transmission|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|response to wounding|vesicle membrane|movement of cell or subcellular component|establishment of organelle localization|neuron projection|regulation of signal transduction|sarcolemma|dendritic spine|somatodendritic compartment|transport vesicle membrane|postsynaptic density|cellular pigmentation|regulation of cell communication|cell communication|membrane organization|establishment of localization by movement along microtubule|signal transduction|endoplasmic reticulum|establishment of localization in cell|regulation of neurotransmitter levels|endosome membrane|positive regulation of secretion|regulation of catalytic activity|cell projection organization|cellular developmental process|actin filament-based process|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|endomembrane system organization|regulation of body fluid levels|endosome|organelle organization|regulation of neurotransmitter secretion|MAPK cascade|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|regulation of gene expression|sarcoplasm|vesicle organization|secretory granule organization|axon|macromolecule modification|cytoskeleton organization|catecholamine secretion|neuron spine|cytoplasmic vesicle|monoamine transport|regulation of G-protein coupled receptor protein signaling pathway|blood coagulation|synaptic vesicle transport|positive regulation of gene expression|cytoplasmic, membrane-bounded vesicle|protein modification process|exocytic vesicle|wound healing|intracellular transport|ion transport|regulation of secretion|axo-dendritic transport|pigment granule organization|stress-activated protein kinase signaling cascade|hemostasis|dendrite|microtubule-based movement|membrane-bounded vesicle|actin cytoskeleton organization|regulation of ion transport|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic vesicle membrane|BLOC-1 complex|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|nervous system development|secretion|vesicle localization|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|organelle transport along microtubule|nucleus|amine transport|neuron development|neuron differentiation|regulation of dopamine receptor signaling pathway|anion transport|melanosome organization|actin cytoskeleton reorganization|regulation of MAPK cascade|vesicle transport along microtubule|cation transport|ammonium transport|anterograde axonal transport|phosphorylation|Golgi vesicle transport|cytosolic transport|regulation of stress-activated MAPK cascade|regulation of anion transport|platelet dense granule organization|neurogenesis|cellular protein modification process|cytoskeleton-dependent intracellular transport|neuron projection morphogenesis|stress-activated MAPK cascade|regulation of kinase activity|dopamine receptor signaling pathway|regulation of protein kinase activity|regulation of JNK cascade|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|melanosome|regulation of dopamine secretion|anterograde synaptic vesicle transport|post-Golgi vesicle-mediated transport|dopamine transport|monovalent inorganic cation transport|synaptic transmission|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity - - - - 6:15522801-15663058 17 27 22 180 204 111 0.151486986721246 0.218668125572278 0.17675112063164 1.43715907784807 1.49153234423051 0.927013662721332 0.182302077641721 1.28523502826664 -2.81762929765429 6.00704177543908e-15 2.7421135346171e-13 DOWN ENSG00000141027 NCOR1 nuclear receptor corepressor 1 [Source:HGNC Symbol;Acc:HGNC:7672] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0000989|GO:0000785|GO:0016043|GO:0043227|GO:0023057|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0008284|GO:0044262|GO:0042127|GO:0007049|GO:0044255|GO:0003712|GO:0006725|GO:0009888|GO:0006810|GO:0022402|GO:1901360|GO:0006082|GO:0007275|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0005874|GO:0044281|GO:0030902|GO:0019637|GO:0046483|GO:0033554|GO:0007420|GO:0022607|GO:0061061|GO:0043231|GO:0019899|GO:0005737|GO:0060322|GO:0017053|GO:0005975|GO:0071559|GO:0009966|GO:0009890|GO:0051186|GO:0003682|GO:0019904|GO:0010646|GO:0006139|GO:0055086|GO:0000790|GO:0007154|GO:0022037|GO:0006629|GO:0007165|GO:0009968|GO:0008134|GO:0021549|GO:0006091|GO:0044249|GO:0010876|GO:0007017|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0048732|GO:0050878|GO:0006996|GO:0000165|GO:0051276|GO:0032268|GO:0016922|GO:0006109|GO:0003677|GO:0030879|GO:0010468|GO:0034645|GO:0003714|GO:0007166|GO:0043412|GO:0007010|GO:0007589|GO:0007417|GO:0001085|GO:0010629|GO:0019693|GO:0051427|GO:0051252|GO:0006325|GO:0042974|GO:0070822|GO:0042975|GO:0044275|GO:0036211|GO:0032269|GO:0071560|GO:0009116|GO:0060537|GO:0006811|GO:0031981|GO:0031098|GO:0032368|GO:0006869|GO:0042826|GO:0048471|GO:0070848|GO:0005654|GO:0005876|GO:0007051|GO:0005694|GO:0016052|GO:0000228|GO:0006461|GO:0007595|GO:0043269|GO:0046966|GO:0070925|GO:0043467|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0000118|GO:0007399|GO:0046903|GO:0071310|GO:1902532|GO:0019439|GO:0051246|GO:0009059|GO:0007517|GO:1902531|GO:0016070|GO:0000226|GO:0046434|GO:0033613|GO:0005856|GO:0005634|GO:0005819|GO:0006757|GO:0006110|GO:0060538|GO:0000975|GO:0051225|GO:0016580|GO:0006820|GO:0001102|GO:0015711|GO:0009259|GO:0043408|GO:0045892|GO:0009117|GO:0032774|GO:2001141|GO:0035257|GO:0071363|GO:0072368|GO:0016310|GO:1902679|GO:0015908|GO:0007179|GO:0046942|GO:0007167|GO:0015630|GO:0009132|GO:0046965|GO:0006163|GO:0032872|GO:0044070|GO:0043409|GO:0019752|GO:0016568|GO:2000191|GO:0009166|GO:0006096|GO:0007219|GO:0014706|GO:0006464|GO:0051403|GO:0042278|GO:0006351|GO:0006355|GO:0015718|GO:0006366|GO:1903507|GO:0046939|GO:0035258|GO:0006352|GO:1903578|GO:0046328|GO:0006357|GO:0006468|GO:0007519|GO:1903506|GO:0044212|GO:0072362|GO:0042325|GO:0007254|GO:0001932|GO:0042326|GO:0032787|GO:0007178|GO:0001933|GO:0000122|GO:0006165|GO:0032873|GO:0006367|GO:0046034|GO:0001012|GO:0046031|GO:0030331|GO:0006090|GO:0046329 developmental process|macromolecular complex|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|chromatin|cellular component organization|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|cellular carbohydrate metabolic process|regulation of cell proliferation|cell cycle|cellular lipid metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|transport|cell cycle process|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|microtubule|small molecule metabolic process|hindbrain development|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|brain development|cellular component assembly|muscle structure development|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|head development|transcriptional repressor complex|carbohydrate metabolic process|response to transforming growth factor beta|regulation of signal transduction|negative regulation of biosynthetic process|cofactor metabolic process|chromatin binding|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|nuclear chromatin|cell communication|metencephalon development|lipid metabolic process|signal transduction|negative regulation of signal transduction|transcription factor binding|cerebellum development|generation of precursor metabolites and energy|cellular biosynthetic process|lipid localization|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|regulation of body fluid levels|organelle organization|MAPK cascade|chromosome organization|regulation of cellular protein metabolic process|ligand-dependent nuclear receptor binding|regulation of carbohydrate metabolic process|DNA binding|mammary gland development|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|cell surface receptor signaling pathway|macromolecule modification|cytoskeleton organization|body fluid secretion|central nervous system development|RNA polymerase II transcription factor binding|negative regulation of gene expression|ribose phosphate metabolic process|hormone receptor binding|regulation of RNA metabolic process|chromatin organization|retinoic acid receptor binding|Sin3-type complex|peroxisome proliferator activated receptor binding|cellular carbohydrate catabolic process|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|nucleoside metabolic process|muscle tissue development|ion transport|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of lipid transport|lipid transport|histone deacetylase binding|perinuclear region of cytoplasm|response to growth factor|nucleoplasm|spindle microtubule|spindle organization|chromosome|carbohydrate catabolic process|nuclear chromosome|protein complex assembly|lactation|regulation of ion transport|thyroid hormone receptor binding|organelle assembly|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|histone deacetylase complex|nervous system development|secretion|cellular response to organic substance|negative regulation of intracellular signal transduction|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|muscle organ development|regulation of intracellular signal transduction|RNA metabolic process|microtubule cytoskeleton organization|organophosphate catabolic process|activating transcription factor binding|cytoskeleton|nucleus|spindle|ATP generation from ADP|regulation of glycolytic process|skeletal muscle organ development|regulatory region DNA binding|spindle assembly|Sin3 complex|anion transport|RNA polymerase II activating transcription factor binding|organic anion transport|ribonucleotide metabolic process|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|nucleotide metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|cellular response to growth factor stimulus|regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter|phosphorylation|negative regulation of RNA biosynthetic process|fatty acid transport|transforming growth factor beta receptor signaling pathway|carboxylic acid transport|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|nucleoside diphosphate metabolic process|retinoid X receptor binding|purine nucleotide metabolic process|regulation of stress-activated MAPK cascade|regulation of anion transport|negative regulation of MAPK cascade|carboxylic acid metabolic process|chromatin modification|regulation of fatty acid transport|nucleotide catabolic process|glycolytic process|Notch signaling pathway|striated muscle tissue development|cellular protein modification process|stress-activated MAPK cascade|purine nucleoside metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|monocarboxylic acid transport|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|nucleotide phosphorylation|steroid hormone receptor binding|DNA-templated transcription, initiation|regulation of ATP metabolic process|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|monocarboxylic acid metabolic process|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|nucleoside diphosphate phosphorylation|negative regulation of stress-activated MAPK cascade|transcription initiation from RNA polymerase II promoter|ATP metabolic process|RNA polymerase II regulatory region DNA binding|ADP metabolic process|estrogen receptor binding|pyruvate metabolic process|negative regulation of JNK cascade K04650 nuclear receptor co-repressor 1[-] hsa05202|hsa04919 Transcriptional misregulation in cancer - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human) 17:16029157-16218185 746 970 1268 3099 3425 3397 1.981141673466 2.34114521196926 3.03606024676629 7.37387843496148 7.46285888436825 8.45475875750937 2.45278237740052 7.76383202561303 -1.66234966820057 6.38375618267041e-15 2.90962835232737e-13 DOWN ENSG00000072840 EVC Ellis van Creveld protein [Source:HGNC Symbol;Acc:HGNC:3497] GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0071944|GO:0031224|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0031090|GO:0009888|GO:0007275|GO:0048513|GO:0060170|GO:0035265|GO:0061061|GO:0005737|GO:0009966|GO:0036064|GO:0010646|GO:0007154|GO:0007165|GO:0031253|GO:0016021|GO:0009967|GO:0051216|GO:0007166|GO:0005815|GO:0045880|GO:0008589|GO:0098868|GO:0001501|GO:0061448|GO:0007517|GO:0005856|GO:0007224|GO:0015630|GO:0003416 developmental process|growth|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|cell periphery|intrinsic component of membrane|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|cilium|organelle membrane|tissue development|multicellular organism development|animal organ development|ciliary membrane|organ growth|muscle structure development|cytoplasm|regulation of signal transduction|ciliary basal body|regulation of cell communication|cell communication|signal transduction|cell projection membrane|integral component of membrane|positive regulation of signal transduction|cartilage development|cell surface receptor signaling pathway|microtubule organizing center|positive regulation of smoothened signaling pathway|regulation of smoothened signaling pathway|bone growth|skeletal system development|connective tissue development|muscle organ development|cytoskeleton|smoothened signaling pathway|microtubule cytoskeleton|endochondral bone growth - - - - 4:5711197-5814305 7 12 2 84 84 76 0.0606006695767476 0.094412877854465 0.0156108314763709 0.65154806808689 0.596648971793417 0.61661379261537 0.0568747929691945 0.621603610831892 -3.45013359049355 6.47184654198314e-15 2.94528211378604e-13 DOWN ENSG00000138463 DIRC2 disrupted in renal carcinoma 2 [Source:HGNC Symbol;Acc:HGNC:16628] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0006810|GO:0043231|GO:0005774|GO:0005737|GO:0016021|GO:0005773|GO:0000323|GO:0005765|GO:0005764 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|transport|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|integral component of membrane|vacuole|lytic vacuole|lysosomal membrane|lysosome - - - - 3:122794795-122881139 73 93 149 421 523 498 1.13890207510745 1.31864788663682 2.09587475259643 5.88496013087842 6.69473590687195 7.28153102919658 1.51780823811357 6.62040902231565 -2.12493082213557 6.83488939241388e-15 3.10576541736871e-13 DOWN ENSG00000115977 AAK1 AP2 associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:19679] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0031252|GO:0005905|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0006810|GO:0043195|GO:0060627|GO:0005102|GO:0043168|GO:0001882|GO:0016772|GO:0031982|GO:0051128|GO:0043231|GO:0005737|GO:0032880|GO:0032403|GO:0043005|GO:0009966|GO:0019897|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0031647|GO:0044306|GO:0000166|GO:0009967|GO:0019538|GO:0005112|GO:0016192|GO:0035612|GO:0007166|GO:0035639|GO:0030424|GO:0043412|GO:0031410|GO:0050821|GO:0001883|GO:0016023|GO:0036211|GO:0032549|GO:0043679|GO:0045747|GO:0030100|GO:0031988|GO:0008593|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0048259|GO:0005524|GO:0030554|GO:0016310|GO:0030135|GO:0004672|GO:0006897|GO:0007219|GO:0006464|GO:0030136|GO:0006468|GO:0006898|GO:0004674|GO:2000369|GO:0072583|GO:0046777 synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|cell leading edge|coated pit|intracellular|protein binding|plasma membrane|endomembrane system|transferase activity|transport|terminal bouton|regulation of vesicle-mediated transport|receptor binding|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|protein complex binding|neuron projection|regulation of signal transduction|extrinsic component of plasma membrane|regulation of cell communication|protein localization|cell communication|signal transduction|regulation of protein stability|neuron projection terminus|nucleotide binding|positive regulation of signal transduction|protein metabolic process|Notch binding|vesicle-mediated transport|AP-2 adaptor complex binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|axon|macromolecule modification|cytoplasmic vesicle|protein stabilization|purine nucleoside binding|cytoplasmic, membrane-bounded vesicle|protein modification process|ribonucleoside binding|axon terminus|positive regulation of Notch signaling pathway|regulation of endocytosis|membrane-bounded vesicle|regulation of Notch signaling pathway|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|regulation of receptor-mediated endocytosis|ATP binding|adenyl nucleotide binding|phosphorylation|coated vesicle|protein kinase activity|endocytosis|Notch signaling pathway|cellular protein modification process|clathrin-coated vesicle|protein phosphorylation|receptor-mediated endocytosis|protein serine/threonine kinase activity|regulation of clathrin-mediated endocytosis|clathrin-mediated endocytosis|protein autophosphorylation - - - - 2:69457997-69674349 222 73 298 1397 1587 1786 0.575581125423543 0.172012002947987 0.696601995988141 3.24524684216868 3.37596991436781 4.33974344019863 0.481398374786557 3.65365339891171 -2.92403660391672 7.02244815837901e-15 3.18614236049007e-13 DOWN ENSG00000278561 PTPN20CP protein tyrosine phosphatase, non-receptor type 20C, pseudogene [Source:HGNC Symbol;Acc:HGNC:23424] - - - - - - 10:48064308-48119455 5 4 5 58 55 52 0.384457549147037 0.279510009039433 0.34658357152902 3.99561001605687 3.46965500517933 3.74704550015625 0.33685037657183 3.73743684046415 -3.47186938192862 7.04835026626339e-15 3.19304171242833e-13 DOWN ENSG00000137261 KIAA0319 KIAA0319 [Source:HGNC Symbol;Acc:HGNC:21580] GO:0040011|GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0048870|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0045595|GO:0048468|GO:0007275|GO:0045596|GO:0016358|GO:0051128|GO:0043231|GO:0005737|GO:0006928|GO:0016477|GO:0010008|GO:0030030|GO:0048869|GO:0016021|GO:0005768|GO:0050768|GO:0031175|GO:2000171|GO:0031344|GO:0050773|GO:0005769|GO:0010721|GO:0001764|GO:0031345|GO:0031901|GO:0007399|GO:0030154|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0045665|GO:0022008|GO:0050767|GO:0010977|GO:0048699|GO:0045664 locomotion|developmental process|cell|membrane|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|cell motility|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of cell differentiation|cell development|multicellular organism development|negative regulation of cell differentiation|dendrite development|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|cell migration|endosome membrane|cell projection organization|cellular developmental process|integral component of membrane|endosome|negative regulation of neurogenesis|neuron projection development|negative regulation of dendrite development|regulation of cell projection organization|regulation of dendrite development|early endosome|negative regulation of cell development|neuron migration|negative regulation of cell projection organization|early endosome membrane|nervous system development|cell differentiation|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|negative regulation of neuron differentiation|neurogenesis|regulation of neurogenesis|negative regulation of neuron projection development|generation of neurons|regulation of neuron differentiation - - - - 6:24544104-24646155 87 74 112 385 396 392 0.475258178296424 0.367384381330693 0.551621096499398 1.88437923978537 1.77489376575303 2.00689288428326 0.464754552042172 1.88872196327389 -2.02286943895876 7.07131363816001e-15 3.19859086899438e-13 DOWN ENSG00000144278 GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 [Source:HGNC Symbol;Acc:HGNC:23242] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0008376|GO:0006464|GO:0016266|GO:0004653|GO:0043687 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|acetylgalactosaminyltransferase activity|cellular protein modification process|O-glycan processing|polypeptide N-acetylgalactosaminyltransferase activity|post-translational protein modification K00710 polypeptide N-acetylgalactosaminyltransferase[2.4.1.41] hsa01100|hsa00512 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human) 2:153871913-154453849 3 4 13 91 127 62 0.0201647334269781 0.0244322288186487 0.0787725702404187 0.54797464831162 0.700316696344079 0.390518748757371 0.0411231774953485 0.54627003113769 -3.73159062991774 7.14090829567978e-15 3.22518420967056e-13 DOWN ENSG00000171889 MIR31HG MIR31 host gene [Source:HGNC Symbol;Acc:HGNC:37187] - - - - - - 9:21455642-21559669 40 53 35 268 260 204 3.79795307358979 4.57349991254839 2.99623952444041 22.7993173620447 20.2549390346995 18.1529992739116 3.78923083685953 20.4024185568853 -2.42876324779174 7.35189242280961e-15 3.31105329563981e-13 DOWN ENSG00000204764 RANBP17 RAN binding protein 17 [Source:HGNC Symbol;Acc:HGNC:14428] GO:0005215|GO:0005623|GO:0005488|GO:0036094|GO:0097159|GO:0005487|GO:0043229|GO:0043167|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0008565|GO:0006810|GO:0043168|GO:0001882|GO:0043231|GO:0019899|GO:0005737|GO:0005635|GO:0045184|GO:0008104|GO:0005049|GO:0051649|GO:0006403|GO:0000166|GO:0035639|GO:0072594|GO:0001883|GO:0015031|GO:0046907|GO:0032549|GO:0034613|GO:0050658|GO:0017038|GO:0017076|GO:0051020|GO:0005634|GO:0006606|GO:0005643|GO:0032561|GO:0033365|GO:0051028|GO:0051169|GO:0006605|GO:0006611|GO:0006886|GO:0031267|GO:0005525|GO:0019001|GO:0006913|GO:0017016|GO:0034504|GO:0051170|GO:0051168|GO:0008536 transporter activity|cell|binding|small molecule binding|organic cyclic compound binding|nucleocytoplasmic transporter activity|intracellular organelle|ion binding|cellular localization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|protein transporter activity|transport|anion binding|nucleoside binding|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|nuclear envelope|establishment of protein localization|protein localization|nuclear export signal receptor activity|establishment of localization in cell|RNA localization|nucleotide binding|purine ribonucleoside triphosphate binding|establishment of protein localization to organelle|purine nucleoside binding|protein transport|intracellular transport|ribonucleoside binding|cellular protein localization|RNA transport|protein import|purine nucleotide binding|GTPase binding|nucleus|protein import into nucleus|nuclear pore|guanyl ribonucleotide binding|protein localization to organelle|mRNA transport|nuclear transport|protein targeting|protein export from nucleus|intracellular protein transport|small GTPase binding|GTP binding|guanyl nucleotide binding|nucleocytoplasmic transport|Ras GTPase binding|protein localization to nucleus|nuclear import|nuclear export|Ran GTPase binding - - - - 5:170861870-171300015 17 8 24 109 154 133 0.0820541590305872 0.0350937165904166 0.104442613412991 0.471394644858603 0.609887481334745 0.601646701006 0.0738634963446649 0.560976275733116 -2.92500629950278 7.35321342201779e-15 3.31105329563981e-13 DOWN ENSG00000068784 SRBD1 S1 RNA binding domain 1 [Source:HGNC Symbol;Acc:HGNC:25521] GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0006807|GO:0071704|GO:0044237|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0006139|GO:0003723 cellular process|metabolic process|binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|RNA binding - - - - 2:45388680-45612165 84 99 122 409 499 368 0.96131440405136 1.02968343803361 1.25881282940266 4.19380409647837 4.68549659837748 3.94696432927804 1.08327022382921 4.2754216747113 -1.98067354573225 7.41226087082362e-15 3.33261500056579e-13 DOWN ENSG00000122965 RBM19 RNA binding motif protein 19 [Source:HGNC Symbol;Acc:HGNC:29098] GO:0032502|GO:0005623|GO:0016020|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043227|GO:0050793|GO:0005622|GO:0048856|GO:0007275|GO:0003676|GO:0043231|GO:0005737|GO:0000166|GO:0040019|GO:0005730|GO:0003723|GO:0009790|GO:0031981|GO:0005654|GO:0005694|GO:0005634|GO:0045995|GO:0044822 developmental process|cell|membrane|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|regulation of developmental process|intracellular|anatomical structure development|multicellular organism development|nucleic acid binding|intracellular membrane-bounded organelle|cytoplasm|nucleotide binding|positive regulation of embryonic development|nucleolus|RNA binding|embryo development|nuclear lumen|nucleoplasm|chromosome|nucleus|regulation of embryonic development|poly(A) RNA binding - - - - 12:113816738-113966371 74 85 103 401 484 309 0.584800435924456 0.610484985071922 0.733881408197648 2.83933150480149 3.13824765823925 2.28855255555015 0.643055609731342 2.7553772395303 -2.09923444365889 8.26023551782624e-15 3.70828678419826e-13 DOWN ENSG00000129991 TNNI3 troponin I type 3 (cardiac) [Source:HGNC Symbol;Acc:HGNC:11947] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0043229|GO:0043167|GO:0009653|GO:0016247|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0048514|GO:0030017|GO:0007507|GO:0009888|GO:0001568|GO:0007275|GO:0048513|GO:0050877|GO:0061061|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0005246|GO:0006928|GO:0009887|GO:0042592|GO:0048729|GO:0048306|GO:0019725|GO:0019904|GO:0044092|GO:0008092|GO:0008217|GO:0050790|GO:0043086|GO:0048869|GO:0030029|GO:0005861|GO:0016248|GO:0003013|GO:0003205|GO:0005829|GO:0006936|GO:0046872|GO:0005865|GO:0003208|GO:0001944|GO:0072358|GO:0019855|GO:0048878|GO:0030048|GO:0048738|GO:0003779|GO:0003007|GO:0090257|GO:0008200|GO:0001976|GO:0060537|GO:0055082|GO:0031014|GO:0043292|GO:0003231|GO:0030172|GO:0001570|GO:0051346|GO:0019900|GO:0060415|GO:0030154|GO:0007517|GO:0072359|GO:0008015|GO:0005856|GO:0050881|GO:0003073|GO:0048644|GO:0006941|GO:0015629|GO:0070252|GO:0030016|GO:0032780|GO:0006939|GO:0006937|GO:0003009|GO:0060047|GO:0001980|GO:0030049|GO:0050801|GO:0003229|GO:0055008|GO:0019901|GO:0014706|GO:0055010|GO:0006873|GO:0043462|GO:0006940|GO:0033275|GO:0060048|GO:0030003|GO:0055065|GO:0006875|GO:0006874|GO:0055074 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|negative regulation of metabolic process|intracellular organelle|ion binding|anatomical structure morphogenesis|channel regulator activity|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|blood vessel morphogenesis|sarcomere|heart development|tissue development|blood vessel development|multicellular organism development|animal organ development|neurological system process|muscle structure development|cation binding|enzyme binding|cytoplasm|muscle system process|calcium channel regulator activity|movement of cell or subcellular component|organ morphogenesis|homeostatic process|tissue morphogenesis|calcium-dependent protein binding|cellular homeostasis|protein domain specific binding|negative regulation of molecular function|cytoskeletal protein binding|regulation of blood pressure|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|troponin complex|channel inhibitor activity|circulatory system process|cardiac chamber development|cytosol|muscle contraction|metal ion binding|striated muscle thin filament|cardiac ventricle morphogenesis|vasculature development|cardiovascular system development|calcium channel inhibitor activity|chemical homeostasis|actin filament-based movement|cardiac muscle tissue development|actin binding|heart morphogenesis|regulation of muscle system process|ion channel inhibitor activity|neurological system process involved in regulation of systemic arterial blood pressure|muscle tissue development|cellular chemical homeostasis|troponin T binding|contractile fiber|cardiac ventricle development|troponin C binding|vasculogenesis|negative regulation of hydrolase activity|kinase binding|muscle tissue morphogenesis|cell differentiation|muscle organ development|circulatory system development|blood circulation|cytoskeleton|musculoskeletal movement|regulation of systemic arterial blood pressure|muscle organ morphogenesis|striated muscle contraction|actin cytoskeleton|actin-mediated cell contraction|myofibril|negative regulation of ATPase activity|smooth muscle contraction|regulation of muscle contraction|skeletal muscle contraction|heart contraction|regulation of systemic arterial blood pressure by ischemic conditions|muscle filament sliding|ion homeostasis|ventricular cardiac muscle tissue development|cardiac muscle tissue morphogenesis|protein kinase binding|striated muscle tissue development|ventricular cardiac muscle tissue morphogenesis|cellular ion homeostasis|regulation of ATPase activity|regulation of smooth muscle contraction|actin-myosin filament sliding|cardiac muscle contraction|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis K12044 troponin I, cardiac muscle[-] hsa04024|hsa04261|hsa05414|hsa05410|hsa04260 cAMP signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human) 19:55151767-55157773 129 111 166 23 18 32 2.33556701215284 1.82644508713452 2.70972348042987 0.373106616547524 0.267384982269485 0.542980782976347 2.29057852657241 0.394490793931119 2.53764848461403 8.63968885693772e-15 3.87281187890418e-13 UP ENSG00000069020 MAST4 microtubule associated serine/threonine kinase family member 4 [Source:HGNC Symbol;Acc:HGNC:19037] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0043168|GO:0001882|GO:0016772|GO:0001817|GO:0043169|GO:0005737|GO:0001816|GO:0007154|GO:0007165|GO:0000166|GO:0044249|GO:0019538|GO:0031323|GO:0042107|GO:0042089|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0032655|GO:0032615|GO:0036211|GO:0032549|GO:0042035|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0051246|GO:0009059|GO:0016773|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0045075|GO:0004672|GO:0006464|GO:0006468|GO:0018193|GO:0004674|GO:0018105 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cytokine production|cation binding|cytoplasm|cytokine production|cell communication|signal transduction|nucleotide binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|cytokine metabolic process|cytokine biosynthetic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|regulation of interleukin-12 production|interleukin-12 production|protein modification process|ribonucleoside binding|regulation of cytokine biosynthetic process|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|phosphotransferase activity, alcohol group as acceptor|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|regulation of interleukin-12 biosynthetic process|protein kinase activity|cellular protein modification process|protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|peptidyl-serine phosphorylation - - - - 5:66596361-67169595 77 101 126 415 403 479 0.179374815094018 0.213833292759555 0.264641340573841 0.866200831087561 0.770273920690915 1.0457728137889 0.219283149475805 0.894082521855792 -2.02761304086752 8.67883388788035e-15 3.88308535427734e-13 DOWN ENSG00000114771 AADAC arylacetamide deacetylase [Source:HGNC Symbol;Acc:HGNC:17] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0009893|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0019222|GO:0044255|GO:0009410|GO:0016788|GO:0044281|GO:0031325|GO:0043231|GO:0019213|GO:0005737|GO:0006629|GO:0005783|GO:0006805|GO:0016021|GO:0031323|GO:0017171|GO:0090207|GO:0046486|GO:0016042|GO:0050996|GO:0044242|GO:0050994|GO:0006638|GO:0071466|GO:0016298|GO:0019216|GO:0052689|GO:0046461|GO:0004806|GO:0010898|GO:0006639|GO:0046464|GO:0006641|GO:0019433 cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|regulation of metabolic process|cellular lipid metabolic process|response to xenobiotic stimulus|hydrolase activity, acting on ester bonds|small molecule metabolic process|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|deacetylase activity|cytoplasm|lipid metabolic process|endoplasmic reticulum|xenobiotic metabolic process|integral component of membrane|regulation of cellular metabolic process|serine hydrolase activity|regulation of triglyceride metabolic process|glycerolipid metabolic process|lipid catabolic process|positive regulation of lipid catabolic process|cellular lipid catabolic process|regulation of lipid catabolic process|neutral lipid metabolic process|cellular response to xenobiotic stimulus|lipase activity|regulation of lipid metabolic process|carboxylic ester hydrolase activity|neutral lipid catabolic process|triglyceride lipase activity|positive regulation of triglyceride catabolic process|acylglycerol metabolic process|acylglycerol catabolic process|triglyceride metabolic process|triglyceride catabolic process - - - - 3:151814037-151828488 39 33 44 228 226 171 1.33399823326972 1.02587591550637 1.35694755295051 6.98758290554253 6.34267488550151 5.48175667050185 1.2389405672422 6.27067148718196 -2.33951295838196 8.70132337239202e-15 3.88308535427734e-13 DOWN ENSG00000144893 MED12L mediator complex subunit 12 like [Source:HGNC Symbol;Acc:HGNC:16050] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0003712|GO:0006725|GO:0008013|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0016592|GO:0001076|GO:0006139|GO:0044249|GO:0031323|GO:0003713|GO:0010468|GO:0034645|GO:0001104|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0010467|GO:0031328|GO:0009059|GO:0001191|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0001105|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0001190 macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|beta-catenin binding|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|mediator complex|transcription factor activity, RNA polymerase II transcription factor binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|RNA polymerase II transcription cofactor activity|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|RNA polymerase II transcription coactivator activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcriptional activator activity, RNA polymerase II transcription factor binding K15162 mediator of RNA polymerase II transcription subunit 12[-] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) 3:151085697-151437072 24 16 52 250 214 236 0.116183395271343 0.0703939798292576 0.226963588521446 1.08436218217987 0.849998873456718 1.07072340392504 0.137846987874016 1.00169481985388 -2.86130339038093 8.70162826425785e-15 3.88308535427734e-13 DOWN ENSG00000101557 USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) [Source:HGNC Symbol;Acc:HGNC:12612] GO:0040011|GO:0032991|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0009986|GO:0044237|GO:0050795|GO:0043227|GO:0071944|GO:0009605|GO:0016787|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0019222|GO:0004857|GO:0006935|GO:0016772|GO:0031982|GO:0033554|GO:0043231|GO:0008233|GO:1903573|GO:0005737|GO:0007267|GO:0050920|GO:0032403|GO:0000502|GO:0007154|GO:0044092|GO:0070062|GO:0050790|GO:0043086|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0036503|GO:0032268|GO:0036459|GO:0043412|GO:0030163|GO:0031410|GO:0030414|GO:0044265|GO:0016023|GO:0036211|GO:0032269|GO:0030433|GO:0051346|GO:0006508|GO:0031988|GO:0044267|GO:0042176|GO:1904292|GO:0070628|GO:1904293|GO:0051246|GO:0016779|GO:0042177|GO:0034976|GO:0004866|GO:0044257|GO:0010466|GO:0010498|GO:1903363|GO:0030162|GO:0052547|GO:1903070|GO:0051603|GO:0004175|GO:0070646|GO:1903069|GO:0045861|GO:0004843|GO:0008234|GO:0006464|GO:0019941|GO:0016579|GO:0010951|GO:0004197|GO:0008192|GO:1901799|GO:1903051|GO:0061136|GO:0043161|GO:0007268|GO:0052548|GO:0006511|GO:0008193|GO:0032434|GO:0032435 locomotion|macromolecular complex|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cell surface|cellular metabolic process|regulation of behavior|membrane-bounded organelle|cell periphery|response to external stimulus|hydrolase activity|enzyme regulator activity|intracellular|protein binding|plasma membrane|protein complex|transferase activity|regulation of metabolic process|enzyme inhibitor activity|chemotaxis|transferase activity, transferring phosphorus-containing groups|vesicle|cellular response to stress|intracellular membrane-bounded organelle|peptidase activity|negative regulation of response to endoplasmic reticulum stress|cytoplasm|cell-cell signaling|regulation of chemotaxis|protein complex binding|proteasome complex|cell communication|negative regulation of molecular function|extracellular exosome|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|ERAD pathway|regulation of cellular protein metabolic process|thiol-dependent ubiquitinyl hydrolase activity|macromolecule modification|protein catabolic process|cytoplasmic vesicle|peptidase inhibitor activity|cellular macromolecule catabolic process|cytoplasmic, membrane-bounded vesicle|protein modification process|negative regulation of cellular protein metabolic process|ER-associated ubiquitin-dependent protein catabolic process|negative regulation of hydrolase activity|proteolysis|membrane-bounded vesicle|cellular protein metabolic process|regulation of protein catabolic process|regulation of ERAD pathway|proteasome binding|negative regulation of ERAD pathway|regulation of protein metabolic process|nucleotidyltransferase activity|negative regulation of protein catabolic process|response to endoplasmic reticulum stress|endopeptidase inhibitor activity|cellular protein catabolic process|negative regulation of peptidase activity|proteasomal protein catabolic process|negative regulation of cellular protein catabolic process|regulation of proteolysis|regulation of peptidase activity|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|proteolysis involved in cellular protein catabolic process|endopeptidase activity|protein modification by small protein removal|regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of proteolysis|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|modification-dependent protein catabolic process|protein deubiquitination|negative regulation of endopeptidase activity|cysteine-type endopeptidase activity|RNA guanylyltransferase activity|negative regulation of proteasomal protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|synaptic transmission|regulation of endopeptidase activity|ubiquitin-dependent protein catabolic process|tRNA guanylyltransferase activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process - - - - 18:158383-214629 516 611 599 2081 2341 1588 3.49084174310678 3.75665378681803 3.65360417893097 12.6139152696142 12.9942015430275 10.0683770363563 3.63369990295193 11.8921646163327 -1.7105001574051 8.80159582202185e-15 3.92183345777075e-13 DOWN ENSG00000079482 OPHN1 oligophrenin 1 [Source:HGNC Symbol;Acc:HGNC:8148] GO:0040011|GO:0032502|GO:0045202|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0008289|GO:0009605|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0050804|GO:0006935|GO:0051640|GO:0048468|GO:0006810|GO:0043195|GO:0007275|GO:0060627|GO:0005102|GO:0043168|GO:0008047|GO:0005543|GO:0051128|GO:0022607|GO:0005737|GO:0007267|GO:0006928|GO:0051656|GO:0043005|GO:0009966|GO:0043197|GO:0036477|GO:0010646|GO:0043085|GO:0007154|GO:0016477|GO:0007165|GO:0051649|GO:0008092|GO:0044306|GO:0050790|GO:0030030|GO:0048869|GO:0030029|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0016192|GO:0051650|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0005096|GO:0030424|GO:0007010|GO:0044309|GO:0030163|GO:0051345|GO:0030695|GO:0003779|GO:0048489|GO:0044265|GO:0000904|GO:0032269|GO:0046907|GO:0043679|GO:0030031|GO:0051966|GO:0030425|GO:0030100|GO:0006508|GO:0030036|GO:0035556|GO:0006929|GO:0044267|GO:0042176|GO:0032990|GO:0007399|GO:0097485|GO:0051648|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0042177|GO:0005856|GO:0035254|GO:0048666|GO:0030182|GO:0015629|GO:0007411|GO:0044257|GO:0006930|GO:0010498|GO:0035255|GO:1903363|GO:0030162|GO:0043087|GO:0061564|GO:0016482|GO:0043547|GO:0051603|GO:0036465|GO:0045861|GO:0006897|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0048812|GO:0007409|GO:0048488|GO:0048699|GO:0006898|GO:1901799|GO:1903051|GO:0061136|GO:0007268|GO:0007270|GO:0072583|GO:0035249 locomotion|developmental process|synapse|signaling|cell|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|lipid binding|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|anatomical structure development|regulation of metabolic process|modulation of synaptic transmission|chemotaxis|organelle localization|cell development|transport|terminal bouton|multicellular organism development|regulation of vesicle-mediated transport|receptor binding|anion binding|enzyme activator activity|phospholipid binding|regulation of cellular component organization|cellular component assembly|cytoplasm|cell-cell signaling|movement of cell or subcellular component|establishment of organelle localization|neuron projection|regulation of signal transduction|dendritic spine|somatodendritic compartment|regulation of cell communication|positive regulation of catalytic activity|cell communication|cell migration|signal transduction|establishment of localization in cell|cytoskeletal protein binding|neuron projection terminus|regulation of catalytic activity|cell projection organization|cellular developmental process|actin filament-based process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|vesicle-mediated transport|establishment of vesicle localization|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|GTPase activator activity|axon|cytoskeleton organization|neuron spine|protein catabolic process|positive regulation of hydrolase activity|GTPase regulator activity|actin binding|synaptic vesicle transport|cellular macromolecule catabolic process|cell morphogenesis involved in differentiation|negative regulation of cellular protein metabolic process|intracellular transport|axon terminus|cell projection assembly|regulation of synaptic transmission, glutamatergic|dendrite|regulation of endocytosis|proteolysis|actin cytoskeleton organization|intracellular signal transduction|substrate-dependent cell migration|cellular protein metabolic process|regulation of protein catabolic process|cell part morphogenesis|nervous system development|neuron projection guidance|vesicle localization|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|negative regulation of protein catabolic process|cytoskeleton|glutamate receptor binding|neuron development|neuron differentiation|actin cytoskeleton|axon guidance|cellular protein catabolic process|substrate-dependent cell migration, cell extension|proteasomal protein catabolic process|ionotropic glutamate receptor binding|negative regulation of cellular protein catabolic process|regulation of proteolysis|regulation of GTPase activity|axon development|cytosolic transport|positive regulation of GTPase activity|proteolysis involved in cellular protein catabolic process|synaptic vesicle recycling|negative regulation of proteolysis|endocytosis|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|neuron projection morphogenesis|axonogenesis|synaptic vesicle endocytosis|generation of neurons|receptor-mediated endocytosis|negative regulation of proteasomal protein catabolic process|negative regulation of proteolysis involved in cellular protein catabolic process|regulation of proteasomal protein catabolic process|synaptic transmission|neuron-neuron synaptic transmission|clathrin-mediated endocytosis|synaptic transmission, glutamatergic - - - - X:68042344-68433913 19 16 70 358 343 565 0.154764028844955 0.118447355281565 0.514086842821565 2.61280237387175 2.29238658472948 4.31323937824593 0.262432742316028 3.07280944561572 -3.54953867017145 8.91925693579019e-15 3.96833824979255e-13 DOWN ENSG00000070476 ZXDC ZXD family zinc finger C [Source:HGNC Symbol;Acc:HGNC:28160] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0019904|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0030275|GO:0010628|GO:0070742|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|protein domain specific binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|LRR domain binding|positive regulation of gene expression|C2H2 zinc finger domain binding|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 3:126437601-126475919 173 246 375 949 1122 1026 1.10736309909494 1.43106291841925 2.16416029222759 5.44262142794378 5.89257176877746 6.15489161925051 1.56752876991393 5.83002827199058 -1.8950109575848 9.10753595108363e-15 4.04607705779242e-13 DOWN ENSG00000107815 C10orf2 chromosome 10 open reading frame 2 [Source:HGNC Symbol;Acc:HGNC:1160] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0042645|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0016817|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0042592|GO:0019725|GO:0006139|GO:0000166|GO:0044249|GO:0010033|GO:0006996|GO:0051276|GO:0003677|GO:0009743|GO:0034645|GO:0035639|GO:0007005|GO:0048878|GO:0001883|GO:0016818|GO:0032549|GO:0055082|GO:0002020|GO:0006390|GO:0005759|GO:0006259|GO:0005739|GO:0006461|GO:0010467|GO:0071310|GO:0017076|GO:0009059|GO:0016070|GO:0000002|GO:0071322|GO:0006260|GO:0001678|GO:0051259|GO:0003697|GO:0032774|GO:0005524|GO:0034284|GO:0030554|GO:0032042|GO:0071103|GO:0016462|GO:0006351|GO:0033500|GO:0071333|GO:0042593|GO:0034214|GO:0006261|GO:0032392|GO:0017111|GO:0006264|GO:0051260|GO:0006268|GO:0032508|GO:0009749|GO:0004386|GO:0003678|GO:0043139 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|mitochondrial nucleoid|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|homeostatic process|cellular homeostasis|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|response to organic substance|organelle organization|chromosome organization|DNA binding|response to carbohydrate|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|mitochondrion organization|chemical homeostasis|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|cellular chemical homeostasis|protease binding|transcription from mitochondrial promoter|mitochondrial matrix|DNA metabolic process|mitochondrion|protein complex assembly|gene expression|cellular response to organic substance|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|mitochondrial genome maintenance|cellular response to carbohydrate stimulus|DNA replication|cellular glucose homeostasis|protein oligomerization|single-stranded DNA binding|RNA biosynthetic process|ATP binding|response to monosaccharide|adenyl nucleotide binding|mitochondrial DNA metabolic process|DNA conformation change|pyrophosphatase activity|transcription, DNA-templated|carbohydrate homeostasis|cellular response to glucose stimulus|glucose homeostasis|protein hexamerization|DNA-dependent DNA replication|DNA geometric change|nucleoside-triphosphatase activity|mitochondrial DNA replication|protein homooligomerization|DNA unwinding involved in DNA replication|DNA duplex unwinding|response to glucose|helicase activity|DNA helicase activity|5'-3' DNA helicase activity - - - - 10:100987367-100994401 1385 1477 1288 292 547 254 22.2559117578846 21.5703083357735 18.6606076838817 4.20412716471497 7.21191932082974 3.82523735312414 20.8289425925133 5.08042794622295 2.03556766939202 9.18636041900884e-15 4.07503126224502e-13 UP ENSG00000115137 DNAJC27 DnaJ heat shock protein family (Hsp40) member C27 [Source:HGNC Symbol;Acc:HGNC:30290] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0009893|GO:0016787|GO:0005622|GO:0005515|GO:0019222|GO:0060341|GO:0006810|GO:0043168|GO:0001882|GO:0031325|GO:0016817|GO:0043231|GO:0005737|GO:0032880|GO:0009966|GO:0045184|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0000166|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0035639|GO:0043412|GO:0032386|GO:0001883|GO:0051223|GO:0015031|GO:0016818|GO:0036211|GO:0070201|GO:0046907|GO:0032549|GO:0051247|GO:0005739|GO:0034613|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:1903827|GO:1902531|GO:0005634|GO:0032561|GO:0033157|GO:0031401|GO:0051169|GO:0043408|GO:0016310|GO:0006611|GO:0070371|GO:0016482|GO:0006886|GO:0043410|GO:0005525|GO:0007264|GO:0006464|GO:0019001|GO:0016462|GO:0006913|GO:0006468|GO:0046825|GO:0017111|GO:0042325|GO:0070374|GO:0001932|GO:0001934|GO:0045204|GO:0070372|GO:0042327|GO:0046822|GO:0071701|GO:0051168|GO:0003924 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|intracellular|protein binding|regulation of metabolic process|regulation of cellular localization|transport|anion binding|nucleoside binding|positive regulation of cellular metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|regulation of signal transduction|establishment of protein localization|regulation of cell communication|protein localization|cell communication|signal transduction|establishment of localization in cell|nucleotide binding|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|regulation of intracellular transport|purine nucleoside binding|regulation of protein transport|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|regulation of establishment of protein localization|intracellular transport|ribonucleoside binding|positive regulation of protein metabolic process|mitochondrion|cellular protein localization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|regulation of cellular protein localization|regulation of intracellular signal transduction|nucleus|guanyl ribonucleotide binding|regulation of intracellular protein transport|positive regulation of protein modification process|nuclear transport|regulation of MAPK cascade|phosphorylation|protein export from nucleus|ERK1 and ERK2 cascade|cytosolic transport|intracellular protein transport|positive regulation of MAPK cascade|GTP binding|small GTPase mediated signal transduction|cellular protein modification process|guanyl nucleotide binding|pyrophosphatase activity|nucleocytoplasmic transport|protein phosphorylation|regulation of protein export from nucleus|nucleoside-triphosphatase activity|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|positive regulation of protein phosphorylation|MAPK export from nucleus|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|regulation of nucleocytoplasmic transport|regulation of MAPK export from nucleus|nuclear export|GTPase activity - - - - 2:24943636-24972094 264 329 322 92 91 84 2.69124110255819 3.04806929077269 2.95950407207261 0.840300631963202 0.761130851357209 0.802523098318538 2.89960482180116 0.80131819387965 1.85540915469984 9.78910738357471e-15 4.3359645671994e-13 UP ENSG00000140950 TLDC1 TBC/LysM-associated domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29325] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0031090|GO:0043231|GO:0005774|GO:0005737|GO:0005773|GO:0000323|GO:0005765|GO:0005764 cell|membrane|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|organelle membrane|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|vacuole|lytic vacuole|lysosomal membrane|lysosome - - - - 16:84476421-84554033 149 95 237 716 850 820 0.995447472269865 0.576815651886047 1.42756244874155 4.28590400731059 4.65928135936815 5.13422283098959 0.999941857632487 4.69313606588944 -2.23063617249608 9.96442248634973e-15 4.40707953937015e-13 DOWN ENSG00000120129 DUSP1 dual specificity phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:3064] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0009888|GO:0009314|GO:0019838|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0051302|GO:0034641|GO:0016788|GO:0046483|GO:0051128|GO:0010942|GO:0045786|GO:0043231|GO:0010243|GO:0005737|GO:0009966|GO:0048598|GO:0051782|GO:0009890|GO:0051445|GO:0006979|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0001704|GO:0044092|GO:0007165|GO:0009968|GO:0051983|GO:0009725|GO:0008219|GO:0050790|GO:0007059|GO:0051301|GO:0043086|GO:0010035|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0051447|GO:0006996|GO:0000165|GO:0051276|GO:0032268|GO:0000819|GO:0000075|GO:0034645|GO:0051053|GO:0014074|GO:0033993|GO:1903047|GO:0043412|GO:0030163|GO:0042542|GO:0051304|GO:0043069|GO:0046683|GO:0044770|GO:0044265|GO:0007492|GO:0007050|GO:0009790|GO:0010038|GO:0036211|GO:0032269|GO:0000278|GO:0007369|GO:0007346|GO:0010564|GO:0001706|GO:0045930|GO:0006508|GO:0006259|GO:0051591|GO:0012501|GO:0014070|GO:0000302|GO:0006796|GO:0032526|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0042176|GO:0007067|GO:0071310|GO:1902532|GO:0051246|GO:0009059|GO:0043068|GO:1902531|GO:0042177|GO:0032870|GO:0005634|GO:0009416|GO:0042578|GO:0043067|GO:0048545|GO:0097305|GO:0010948|GO:0044257|GO:0031577|GO:0016311|GO:0043065|GO:2001251|GO:0010498|GO:0071850|GO:2000279|GO:0043408|GO:0007093|GO:0007088|GO:1903363|GO:0044772|GO:0030162|GO:0051592|GO:0007094|GO:0016310|GO:0043627|GO:0071174|GO:0033044|GO:0070371|GO:0090266|GO:1901990|GO:2000278|GO:0051603|GO:0045839|GO:0000070|GO:0032355|GO:0042981|GO:0051306|GO:0045861|GO:0043066|GO:0016791|GO:0043409|GO:0033673|GO:1901987|GO:0051438|GO:0007091|GO:0033574|GO:0006464|GO:0031960|GO:0071897|GO:0043549|GO:0006915|GO:1901976|GO:1901991|GO:0006470|GO:0030071|GO:0051384|GO:0071173|GO:0090231|GO:0045859|GO:0006469|GO:0010965|GO:0019941|GO:0006468|GO:0043407|GO:0043405|GO:0042325|GO:0004721|GO:0001932|GO:0042326|GO:1901799|GO:2000816|GO:0001933|GO:0070372|GO:1903051|GO:0070373|GO:0061136|GO:0043161|GO:0032446|GO:0035335|GO:0006511|GO:0071901|GO:0031396|GO:0032434|GO:0032435|GO:0035970|GO:0000188|GO:0008138|GO:0033549|GO:0071900|GO:0004725|GO:0008330|GO:0016567|GO:0004726|GO:0017017 developmental process|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|hydrolase activity|biosynthetic process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|tissue development|response to radiation|growth factor binding|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|regulation of cell division|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|regulation of signal transduction|embryonic morphogenesis|negative regulation of cell division|negative regulation of biosynthetic process|regulation of meiotic cell cycle|response to oxidative stress|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|formation of primary germ layer|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|regulation of chromosome segregation|response to hormone|cell death|regulation of catalytic activity|chromosome segregation|cell division|negative regulation of catalytic activity|response to inorganic substance|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of meiotic cell cycle|organelle organization|MAPK cascade|chromosome organization|regulation of cellular protein metabolic process|sister chromatid segregation|cell cycle checkpoint|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|response to purine-containing compound|response to lipid|mitotic cell cycle process|macromolecule modification|protein catabolic process|response to hydrogen peroxide|chromosome separation|negative regulation of programmed cell death|response to organophosphorus|cell cycle phase transition|cellular macromolecule catabolic process|endoderm development|cell cycle arrest|embryo development|response to metal ion|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|gastrulation|regulation of mitotic cell cycle|regulation of cell cycle process|endoderm formation|negative regulation of mitotic cell cycle|proteolysis|DNA metabolic process|response to cAMP|programmed cell death|response to organic cyclic compound|response to reactive oxygen species|phosphate-containing compound metabolic process|response to retinoic acid|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|mitotic nuclear division|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of programmed cell death|regulation of intracellular signal transduction|negative regulation of protein catabolic process|cellular response to hormone stimulus|nucleus|response to light stimulus|phosphoric ester hydrolase activity|regulation of programmed cell death|response to steroid hormone|response to alcohol|negative regulation of cell cycle process|cellular protein catabolic process|spindle checkpoint|dephosphorylation|positive regulation of apoptotic process|negative regulation of chromosome organization|proteasomal protein catabolic process|mitotic cell cycle arrest|negative regulation of DNA biosynthetic process|regulation of MAPK cascade|mitotic cell cycle checkpoint|regulation of mitotic nuclear division|negative regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of proteolysis|response to calcium ion|mitotic spindle assembly checkpoint|phosphorylation|response to estrogen|mitotic spindle checkpoint|regulation of chromosome organization|ERK1 and ERK2 cascade|regulation of mitotic cell cycle spindle assembly checkpoint|regulation of mitotic cell cycle phase transition|regulation of DNA biosynthetic process|proteolysis involved in cellular protein catabolic process|negative regulation of mitotic nuclear division|mitotic sister chromatid segregation|response to estradiol|regulation of apoptotic process|mitotic sister chromatid separation|negative regulation of proteolysis|negative regulation of apoptotic process|phosphatase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|regulation of cell cycle phase transition|regulation of ubiquitin-protein transferase activity|metaphase/anaphase transition of mitotic cell cycle|response to testosterone|cellular protein modification process|response to corticosteroid|DNA biosynthetic process|regulation of kinase activity|apoptotic process|regulation of cell cycle checkpoint|negative regulation of mitotic cell cycle phase transition|protein dephosphorylation|regulation of mitotic metaphase/anaphase transition|response to glucocorticoid|spindle assembly checkpoint|regulation of spindle checkpoint|regulation of protein kinase activity|negative regulation of protein kinase activity|regulation of mitotic sister chromatid separation|modification-dependent protein catabolic process|protein phosphorylation|negative regulation of MAP kinase activity|regulation of MAP kinase activity|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of proteasomal protein catabolic process|negative regulation of mitotic sister chromatid separation|negative regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|negative regulation of proteolysis involved in cellular protein catabolic process|negative regulation of ERK1 and ERK2 cascade|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|peptidyl-tyrosine dephosphorylation|ubiquitin-dependent protein catabolic process|negative regulation of protein serine/threonine kinase activity|regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|peptidyl-threonine dephosphorylation|inactivation of MAPK activity|protein tyrosine/serine/threonine phosphatase activity|MAP kinase phosphatase activity|regulation of protein serine/threonine kinase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity|protein ubiquitination|non-membrane spanning protein tyrosine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity K04459 dual specificity MAP kinase phosphatase[3.1.3.48] hsa04010|hsa04726 MAPK signaling pathway - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human) 5:172768090-172771195 255 269 381 76 95 78 8.93406974425127 8.5652871143772 12.0350686980621 2.38571195813933 2.73086857117742 2.5611306538958 9.84480851889686 2.55923706107085 1.94364935623086 1.01775379522576e-14 4.49467778146004e-13 UP ENSG00000197714 ZNF460 zinc finger protein 460 [Source:HGNC Symbol;Acc:HGNC:21628] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 19:57280051-57293569 12 16 11 88 95 115 0.1492385753036 0.180836292768128 0.12333424714961 0.980541961105014 0.969343116245995 1.34033895093938 0.151136371740446 1.09674134276346 -2.85930051901046 1.05400150018802e-14 4.64788194780105e-13 DOWN ENSG00000105662 CRTC1 CREB regulated transcription coactivator 1 [Source:HGNC Symbol;Acc:HGNC:16062] GO:0032502|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0042752|GO:0042995|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0009628|GO:0044237|GO:0023051|GO:1900273|GO:0044297|GO:0016043|GO:0043227|GO:0044708|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0016032|GO:0050804|GO:0042391|GO:0045595|GO:0006725|GO:0048468|GO:0043025|GO:0009314|GO:0051130|GO:1901360|GO:0007275|GO:0050877|GO:0016358|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0050806|GO:0022607|GO:0050803|GO:0045597|GO:0043231|GO:0005737|GO:0007267|GO:0043005|GO:0036477|GO:0010646|GO:0006139|GO:0007154|GO:0008134|GO:0007611|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0009649|GO:0051090|GO:0031175|GO:0031344|GO:0010468|GO:0034645|GO:0048167|GO:0050773|GO:0060081|GO:0010720|GO:0051252|GO:0008140|GO:0031346|GO:0010628|GO:0007613|GO:0051091|GO:0031981|GO:0050769|GO:0030425|GO:0005654|GO:0006461|GO:0060291|GO:0010467|GO:0007399|GO:0050890|GO:0031328|GO:0009059|GO:0030154|GO:1900006|GO:0016070|GO:0010557|GO:0005634|GO:0009416|GO:0051960|GO:0043153|GO:0048666|GO:0030182|GO:0045893|GO:0010975|GO:0051259|GO:0032774|GO:2001141|GO:0009648|GO:0032793|GO:1900271|GO:0022008|GO:0050767|GO:0010976|GO:0006351|GO:0006355|GO:0045666|GO:0045944|GO:0006366|GO:0006357|GO:0048699|GO:1903506|GO:0051260|GO:0051262|GO:0045664|GO:0007268|GO:0051289 developmental process|synapse|behavior|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|regulation of circadian rhythm|cell projection|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|positive regulation of long-term synaptic potentiation|cell body|cellular component organization|membrane-bounded organelle|single-organism behavior|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|viral process|modulation of synaptic transmission|regulation of membrane potential|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|neuronal cell body|response to radiation|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|neurological system process|dendrite development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of synaptic transmission|cellular component assembly|regulation of synapse structure or activity|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|neuron projection|somatodendritic compartment|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|transcription factor binding|learning or memory|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|entrainment of circadian clock|regulation of sequence-specific DNA binding transcription factor activity|neuron projection development|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of synaptic plasticity|regulation of dendrite development|membrane hyperpolarization|positive regulation of cell development|regulation of RNA metabolic process|cAMP response element binding protein binding|positive regulation of cell projection organization|positive regulation of gene expression|memory|positive regulation of sequence-specific DNA binding transcription factor activity|nuclear lumen|positive regulation of neurogenesis|dendrite|nucleoplasm|protein complex assembly|long-term synaptic potentiation|gene expression|nervous system development|cognition|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of dendrite development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|regulation of nervous system development|entrainment of circadian clock by photoperiod|neuron development|neuron differentiation|positive regulation of transcription, DNA-templated|regulation of neuron projection development|protein oligomerization|RNA biosynthetic process|regulation of RNA biosynthetic process|photoperiodism|positive regulation of CREB transcription factor activity|regulation of long-term synaptic potentiation|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|protein homooligomerization|protein tetramerization|regulation of neuron differentiation|synaptic transmission|protein homotetramerization K15309 CREB-regulated transcription coactivator 1[-] hsa05166 HTLV-I infection - Homo sapiens (human) 19:18683677-18782333 41 32 37 172 217 221 0.334669020683939 0.237386760504295 0.272300317297661 1.2579185251677 1.45329528952282 1.69062810569884 0.281452032828632 1.46728064012979 -2.38218386172404 1.06826508650009e-14 4.70383272748872e-13 DOWN ENSG00000071242 RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 [Source:HGNC Symbol;Acc:HGNC:10431] GO:0040011|GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0006955|GO:0019953|GO:0044237|GO:0003006|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0032504|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0048609|GO:0019222|GO:0007507|GO:0002757|GO:0051726|GO:0042127|GO:0007049|GO:0006935|GO:0045087|GO:0001556|GO:0048468|GO:0009994|GO:0022402|GO:0010941|GO:0007275|GO:0048513|GO:0050877|GO:0051302|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0051128|GO:0033554|GO:0010942|GO:0045786|GO:0043231|GO:0043169|GO:0005737|GO:0002218|GO:0030529|GO:0007267|GO:0005635|GO:0006928|GO:0051782|GO:0051445|GO:0050776|GO:0007154|GO:0007276|GO:0007165|GO:0007126|GO:0050778|GO:0008219|GO:0008285|GO:0008217|GO:0031965|GO:0000166|GO:0030030|GO:0051301|GO:0048869|GO:0019538|GO:0023014|GO:0010033|GO:0007281|GO:0003013|GO:0051447|GO:0006996|GO:0000165|GO:0000902|GO:0005829|GO:0031175|GO:0009743|GO:0040020|GO:0010468|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0002758|GO:0072358|GO:0005840|GO:0001883|GO:0051604|GO:0000904|GO:0048477|GO:0010628|GO:0036211|GO:0001976|GO:0032549|GO:0031981|GO:0031098|GO:0010564|GO:0070848|GO:0006508|GO:0005654|GO:0045835|GO:0002764|GO:0016301|GO:0012501|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0017076|GO:0051246|GO:0030154|GO:0048858|GO:0043068|GO:0048599|GO:0048469|GO:0072359|GO:0016773|GO:0007292|GO:0008015|GO:0005856|GO:0005634|GO:0005819|GO:0043067|GO:0045089|GO:0003073|GO:0045088|GO:0010948|GO:0048666|GO:0030182|GO:0071322|GO:0007411|GO:0043065|GO:0016485|GO:0003081|GO:0000287|GO:0005524|GO:0060047|GO:0030162|GO:0071363|GO:0030554|GO:0016310|GO:0038179|GO:0002221|GO:0002035|GO:0061564|GO:0007167|GO:0015630|GO:0042981|GO:0004672|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0051403|GO:0006915|GO:0048011|GO:0002224|GO:0007409|GO:0006468|GO:0048699|GO:0004712|GO:0070613|GO:0018193|GO:0002016|GO:0004674|GO:0010657|GO:0007268|GO:0007169|GO:0034166|GO:0034134|GO:0038124|GO:0002756|GO:0018105|GO:0034138|GO:0002755|GO:0034146|GO:0034142|GO:0038123|GO:0034162|GO:0004711|GO:0010659|GO:0035666 locomotion|developmental process|macromolecular complex|reproduction|immune system process|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|immune response|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|heart development|immune response-activating signal transduction|regulation of cell cycle|regulation of cell proliferation|cell cycle|chemotaxis|innate immune response|oocyte maturation|cell development|oocyte differentiation|cell cycle process|regulation of cell death|multicellular organism development|animal organ development|neurological system process|regulation of cell division|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|cellular response to stress|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|cytoplasm|activation of innate immune response|intracellular ribonucleoprotein complex|cell-cell signaling|nuclear envelope|movement of cell or subcellular component|negative regulation of cell division|regulation of meiotic cell cycle|regulation of immune response|cell communication|gamete generation|signal transduction|meiotic nuclear division|positive regulation of immune response|cell death|negative regulation of cell proliferation|regulation of blood pressure|nuclear membrane|nucleotide binding|cell projection organization|cell division|cellular developmental process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|germ cell development|circulatory system process|negative regulation of meiotic cell cycle|organelle organization|MAPK cascade|cell morphogenesis|cytosol|neuron projection development|response to carbohydrate|regulation of meiotic nuclear division|regulation of gene expression|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|cardiovascular system development|ribosome|purine nucleoside binding|protein maturation|cell morphogenesis involved in differentiation|oogenesis|positive regulation of gene expression|protein modification process|neurological system process involved in regulation of systemic arterial blood pressure|ribonucleoside binding|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of cell cycle process|response to growth factor|proteolysis|nucleoplasm|negative regulation of meiotic nuclear division|immune response-regulating signaling pathway|kinase activity|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|oocyte development|cell maturation|circulatory system development|phosphotransferase activity, alcohol group as acceptor|female gamete generation|blood circulation|cytoskeleton|nucleus|spindle|regulation of programmed cell death|positive regulation of innate immune response|regulation of systemic arterial blood pressure|regulation of innate immune response|negative regulation of cell cycle process|neuron development|neuron differentiation|cellular response to carbohydrate stimulus|axon guidance|positive regulation of apoptotic process|protein processing|regulation of systemic arterial blood pressure by renin-angiotensin|magnesium ion binding|ATP binding|heart contraction|regulation of proteolysis|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|neurotrophin signaling pathway|pattern recognition receptor signaling pathway|brain renin-angiotensin system|axon development|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|regulation of apoptotic process|protein kinase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|stress-activated MAPK cascade|apoptotic process|neurotrophin TRK receptor signaling pathway|toll-like receptor signaling pathway|axonogenesis|protein phosphorylation|generation of neurons|protein serine/threonine/tyrosine kinase activity|regulation of protein processing|peptidyl-amino acid modification|regulation of blood volume by renin-angiotensin|protein serine/threonine kinase activity|muscle cell apoptotic process|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|MyD88-independent toll-like receptor signaling pathway|peptidyl-serine phosphorylation|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|ribosomal protein S6 kinase activity|cardiac muscle cell apoptotic process|TRIF-dependent toll-like receptor signaling pathway K04373 p90 ribosomal S6 kinase[2.7.11.1] hsa04010|hsa04114|hsa04722|hsa04931|hsa04914|hsa04720|hsa04150 MAPK signaling pathway - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human) 6:166409364-166906451 24 34 52 194 228 343 0.111902430407017 0.14407542486905 0.218600748498805 0.810460793385648 0.872237821965388 1.49883536580142 0.158192867924957 1.06051132705082 -2.74500356706496 1.07838005125295e-14 4.74137821061938e-13 DOWN ENSG00000197976 AKAP17A A-kinase anchoring protein 17A [Source:HGNC Symbol;Acc:HGNC:18783] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0030529|GO:0051018|GO:0001775|GO:0006139|GO:0046649|GO:0007154|GO:0007165|GO:0000166|GO:0044249|GO:0031323|GO:0042113|GO:0010468|GO:0034645|GO:0003723|GO:0051252|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006396|GO:0032774|GO:2001141|GO:0043484|GO:0016604|GO:0016071|GO:0044822|GO:0006351|GO:0006355|GO:0016607|GO:1903506|GO:0006397|GO:0008380 macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|protein kinase A binding|cell activation|nucleobase-containing compound metabolic process|lymphocyte activation|cell communication|signal transduction|nucleotide binding|cellular biosynthetic process|regulation of cellular metabolic process|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|regulation of RNA metabolic process|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA processing|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of RNA splicing|nuclear body|mRNA metabolic process|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|regulation of nucleic acid-templated transcription|mRNA processing|RNA splicing - - - - X:1591593-1602514 3062 2672 2356 833 1061 825 33.2100952792876 26.3379200479204 23.0385187212113 8.09483087559983 9.44166252844763 8.38586017500865 27.5288446828064 8.64078452635204 1.67170985421814 1.11974636080286e-14 4.91601586108948e-13 UP ENSG00000111596 CNOT2 CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0044089|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0016787|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:1902117|GO:0001824|GO:0045595|GO:0003712|GO:0006725|GO:0048468|GO:1902115|GO:0051130|GO:1901360|GO:0007275|GO:0034641|GO:0016788|GO:0046483|GO:0051128|GO:0001825|GO:0022607|GO:0043231|GO:0030014|GO:2000036|GO:0005737|GO:0030529|GO:0001076|GO:0009966|GO:0030015|GO:0009890|GO:0016458|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0008134|GO:0009725|GO:0048869|GO:0044249|GO:0022613|GO:0019827|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0035770|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:2000736|GO:0033993|GO:0010603|GO:0001104|GO:0031047|GO:0010629|GO:0051252|GO:0044265|GO:0009790|GO:0032269|GO:0022618|GO:0004518|GO:0033143|GO:0010606|GO:0033144|GO:0001221|GO:0070925|GO:0014070|GO:0043603|GO:0033043|GO:0044267|GO:0010467|GO:0071310|GO:0019439|GO:0051246|GO:0009059|GO:0030154|GO:0009755|GO:0016070|GO:0032870|GO:0005634|GO:0001829|GO:0036464|GO:0048545|GO:0030522|GO:0010638|GO:0043401|GO:0006401|GO:0001222|GO:0048863|GO:0043043|GO:0090501|GO:0009792|GO:0034622|GO:0045892|GO:0032774|GO:0017148|GO:2001141|GO:0010608|GO:1902679|GO:0071383|GO:0071407|GO:0030518|GO:0006412|GO:0004527|GO:0016071|GO:0006417|GO:0004540|GO:0090305|GO:0033962|GO:0033147|GO:0071396|GO:0006351|GO:0006355|GO:0000932|GO:0033146|GO:0030520|GO:0004532|GO:0006366|GO:1903507|GO:0006357|GO:0008408|GO:1903506|GO:0006402|GO:0001226|GO:0043009|GO:0090503|GO:0000122|GO:0000956|GO:0000175|GO:0001701|GO:0016896|GO:0000289|GO:0004535|GO:0000288 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|hydrolase activity|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of organelle assembly|blastocyst development|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|regulation of organelle assembly|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|regulation of cellular component organization|blastocyst formation|cellular component assembly|intracellular membrane-bounded organelle|CCR4-NOT complex|regulation of stem cell population maintenance|cytoplasm|intracellular ribonucleoprotein complex|transcription factor activity, RNA polymerase II transcription factor binding|regulation of signal transduction|CCR4-NOT core complex|negative regulation of biosynthetic process|gene silencing|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|transcription factor binding|response to hormone|cellular developmental process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|stem cell population maintenance|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|ribonucleoprotein granule|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|regulation of stem cell differentiation|response to lipid|regulation of cytoplasmic mRNA processing body assembly|RNA polymerase II transcription cofactor activity|gene silencing by RNA|negative regulation of gene expression|regulation of RNA metabolic process|cellular macromolecule catabolic process|embryo development|negative regulation of cellular protein metabolic process|ribonucleoprotein complex assembly|nuclease activity|regulation of intracellular steroid hormone receptor signaling pathway|positive regulation of cytoplasmic mRNA processing body assembly|negative regulation of intracellular steroid hormone receptor signaling pathway|transcription cofactor binding|organelle assembly|response to organic cyclic compound|cellular amide metabolic process|regulation of organelle organization|cellular protein metabolic process|gene expression|cellular response to organic substance|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|nucleus|trophectodermal cell differentiation|cytoplasmic ribonucleoprotein granule|response to steroid hormone|intracellular receptor signaling pathway|positive regulation of organelle organization|steroid hormone mediated signaling pathway|RNA catabolic process|transcription corepressor binding|stem cell differentiation|peptide biosynthetic process|RNA phosphodiester bond hydrolysis|embryo development ending in birth or egg hatching|cellular macromolecular complex assembly|negative regulation of transcription, DNA-templated|RNA biosynthetic process|negative regulation of translation|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|translation|exonuclease activity|mRNA metabolic process|regulation of translation|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|cytoplasmic mRNA processing body assembly|negative regulation of intracellular estrogen receptor signaling pathway|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|cytoplasmic mRNA processing body|regulation of intracellular estrogen receptor signaling pathway|intracellular estrogen receptor signaling pathway|exoribonuclease activity|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|3'-5' exonuclease activity|regulation of nucleic acid-templated transcription|mRNA catabolic process|RNA polymerase II transcription corepressor binding|chordate embryonic development|RNA phosphodiester bond hydrolysis, exonucleolytic|negative regulation of transcription from RNA polymerase II promoter|nuclear-transcribed mRNA catabolic process|3'-5'-exoribonuclease activity|in utero embryonic development|exoribonuclease activity, producing 5'-phosphomonoesters|nuclear-transcribed mRNA poly(A) tail shortening|poly(A)-specific ribonuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K12605 CCR4-NOT transcription complex subunit 2[-] hsa03018 RNA degradation - Homo sapiens (human) 12:70242994-70354993 286 343 408 1056 1181 1033 0.873256211700254 0.951809687822277 1.12318287784874 2.88893409657685 2.95865187596638 2.95600543957922 0.98274959245709 2.93453047070748 -1.57823392294063 1.17088852929097e-14 5.13299649830436e-13 DOWN ENSG00000179889 PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28995] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0005622|GO:0012505|GO:0016830|GO:0006082|GO:0043168|GO:0044281|GO:0043231|GO:0005737|GO:0030170|GO:0005794|GO:0016831|GO:0019752 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|intracellular|endomembrane system|carbon-carbon lyase activity|organic acid metabolic process|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|pyridoxal phosphate binding|Golgi apparatus|carboxy-lyase activity|carboxylic acid metabolic process - - - - 16:14974591-15139339 627 724 987 2458 2484 2757 2.44714363211155 2.56809024247197 3.47314621419607 8.59550198710064 7.95446972825116 10.0845684148229 2.8294600295932 8.87818004339157 -1.649737208511 1.19182667808249e-14 5.2171251682514e-13 DOWN ENSG00000008086 CDKL5 cyclin-dependent kinase-like 5 [Source:HGNC Symbol;Acc:HGNC:11411] GO:0040011|GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0009653|GO:0016043|GO:0030427|GO:0045927|GO:0043227|GO:0071944|GO:0040008|GO:0009893|GO:0031252|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0045595|GO:0048468|GO:0051130|GO:0007275|GO:0032535|GO:0016358|GO:0043168|GO:0030307|GO:0001882|GO:0016772|GO:0051128|GO:0030426|GO:0032839|GO:0045597|GO:0043231|GO:0019899|GO:0005737|GO:0044292|GO:0001726|GO:0006928|GO:0043005|GO:0048639|GO:0036477|GO:0043085|GO:0032838|GO:0016477|GO:0048588|GO:0048638|GO:0031256|GO:0050790|GO:0000166|GO:0030030|GO:0031253|GO:0048869|GO:0019538|GO:0001558|GO:0060560|GO:0000902|GO:0031175|GO:0031344|GO:0035639|GO:0043412|GO:0050773|GO:0051345|GO:0010720|GO:0048813|GO:0001883|GO:0031346|GO:0000904|GO:0036211|GO:0001764|GO:0032549|GO:0031981|GO:0050769|GO:0030425|GO:0008361|GO:0005654|GO:0022604|GO:0016301|GO:0044294|GO:0032587|GO:0006796|GO:0044267|GO:0030516|GO:0032990|GO:0007399|GO:0017076|GO:0010770|GO:0051020|GO:0030154|GO:0048858|GO:1900006|GO:0016773|GO:0005634|GO:1990138|GO:0051960|GO:0045773|GO:0048666|GO:0030182|GO:0010975|GO:0010769|GO:0005524|GO:0043087|GO:0030554|GO:0016310|GO:0050775|GO:0061564|GO:0043547|GO:0048814|GO:0031267|GO:0004672|GO:0050772|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0010976|GO:0048675|GO:0045666|GO:0017016|GO:0007409|GO:0006468|GO:0048699|GO:0004674|GO:0097472|GO:0050770|GO:0045664|GO:0017048|GO:0004693|GO:0046777|GO:0048365 locomotion|developmental process|growth|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|anatomical structure morphogenesis|cellular component organization|site of polarized growth|positive regulation of growth|membrane-bounded organelle|cell periphery|regulation of growth|positive regulation of metabolic process|cell leading edge|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|regulation of cell differentiation|cell development|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component size|dendrite development|anion binding|positive regulation of cell growth|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|growth cone|dendrite cytoplasm|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|dendrite terminus|ruffle|movement of cell or subcellular component|neuron projection|positive regulation of developmental growth|somatodendritic compartment|positive regulation of catalytic activity|cell projection cytoplasm|cell migration|developmental cell growth|regulation of developmental growth|leading edge membrane|regulation of catalytic activity|nucleotide binding|cell projection organization|cell projection membrane|cellular developmental process|protein metabolic process|regulation of cell growth|developmental growth involved in morphogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|purine ribonucleoside triphosphate binding|macromolecule modification|regulation of dendrite development|positive regulation of hydrolase activity|positive regulation of cell development|dendrite morphogenesis|purine nucleoside binding|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|protein modification process|neuron migration|ribonucleoside binding|nuclear lumen|positive regulation of neurogenesis|dendrite|regulation of cell size|nucleoplasm|regulation of cell morphogenesis|kinase activity|dendritic growth cone|ruffle membrane|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of axon extension|cell part morphogenesis|nervous system development|purine nucleotide binding|positive regulation of cell morphogenesis involved in differentiation|GTPase binding|cell differentiation|cell projection morphogenesis|positive regulation of dendrite development|phosphotransferase activity, alcohol group as acceptor|nucleus|neuron projection extension|regulation of nervous system development|positive regulation of axon extension|neuron development|neuron differentiation|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|ATP binding|regulation of GTPase activity|adenyl nucleotide binding|phosphorylation|positive regulation of dendrite morphogenesis|axon development|positive regulation of GTPase activity|regulation of dendrite morphogenesis|small GTPase binding|protein kinase activity|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|axon extension|positive regulation of neuron differentiation|Ras GTPase binding|axonogenesis|protein phosphorylation|generation of neurons|protein serine/threonine kinase activity|cyclin-dependent protein kinase activity|regulation of axonogenesis|regulation of neuron differentiation|Rho GTPase binding|cyclin-dependent protein serine/threonine kinase activity|protein autophosphorylation|Rac GTPase binding - - - - X:18425583-18653629 67 21 42 356 355 483 0.276413194380509 0.0787392842831173 0.156223692727647 1.31592290385446 1.20165363502032 1.86749297050103 0.170458723797091 1.4616898364586 -3.10014286958945 1.2064297986267e-14 5.27331701437797e-13 DOWN ENSG00000180957 PITPNB phosphatidylinositol transfer protein beta [Source:HGNC Symbol;Acc:HGNC:9002] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0008289|GO:0009058|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0044255|GO:0006810|GO:0044281|GO:0031982|GO:0019637|GO:0043231|GO:0005737|GO:0006629|GO:0005783|GO:0070062|GO:0044249|GO:0010876|GO:0005794|GO:0008654|GO:0046486|GO:0006811|GO:0006869|GO:0006796|GO:0008610|GO:0000139|GO:0006644|GO:0015914|GO:0006820|GO:0015711|GO:0046474|GO:0006650 cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|lipid binding|biosynthetic process|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|transport|small molecule metabolic process|vesicle|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|endoplasmic reticulum|extracellular exosome|cellular biosynthetic process|lipid localization|Golgi apparatus|phospholipid biosynthetic process|glycerolipid metabolic process|ion transport|lipid transport|phosphate-containing compound metabolic process|lipid biosynthetic process|Golgi membrane|phospholipid metabolic process|phospholipid transport|anion transport|organic anion transport|glycerophospholipid biosynthetic process|glycerophospholipid metabolic process - - - - 22:27851669-27920134 237 195 376 1127 1272 884 1.97532890534081 1.47708899847725 2.82549155362091 8.41614427417827 8.69854777755165 6.90514111652463 2.09263648581299 8.00661105608485 -1.93587000367153 1.24575416055833e-14 5.43724337855385e-13 DOWN ENSG00000102910 LONP2 lon peptidase 2, peroxisomal [Source:HGNC Symbol;Acc:HGNC:20598] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0019222|GO:0044255|GO:0006810|GO:0006082|GO:0005102|GO:0043168|GO:0044281|GO:0001882|GO:0016817|GO:0043231|GO:0008233|GO:0019899|GO:0005737|GO:0045184|GO:0008104|GO:0055085|GO:0006629|GO:0042180|GO:0051649|GO:0000166|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0055114|GO:0017171|GO:0035639|GO:0072594|GO:0030163|GO:0016042|GO:0044242|GO:0006631|GO:0001883|GO:0051604|GO:0015031|GO:0044265|GO:0050994|GO:0016818|GO:0034440|GO:0046907|GO:0032549|GO:0002020|GO:0007031|GO:0006508|GO:0034613|GO:0010565|GO:0014070|GO:0008236|GO:0044267|GO:0010467|GO:0017038|GO:0019216|GO:0017076|GO:0030258|GO:0071806|GO:0005634|GO:0019217|GO:0044257|GO:0004252|GO:0006625|GO:0033365|GO:0016485|GO:0005777|GO:0005524|GO:0046395|GO:0030554|GO:0005782|GO:0006605|GO:0006886|GO:0051603|GO:0065002|GO:0031998|GO:0004175|GO:0072663|GO:0019752|GO:0009062|GO:0019395|GO:0016462|GO:0004176|GO:0006635|GO:0046320|GO:0017111|GO:0016558|GO:0032787|GO:0006515|GO:0016887|GO:0042623 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|regulation of metabolic process|cellular lipid metabolic process|transport|organic acid metabolic process|receptor binding|anion binding|small molecule metabolic process|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|peptidase activity|enzyme binding|cytoplasm|establishment of protein localization|protein localization|transmembrane transport|lipid metabolic process|cellular ketone metabolic process|establishment of localization in cell|nucleotide binding|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|serine hydrolase activity|purine ribonucleoside triphosphate binding|establishment of protein localization to organelle|protein catabolic process|lipid catabolic process|cellular lipid catabolic process|fatty acid metabolic process|purine nucleoside binding|protein maturation|protein transport|cellular macromolecule catabolic process|regulation of lipid catabolic process|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|lipid oxidation|intracellular transport|ribonucleoside binding|protease binding|peroxisome organization|proteolysis|cellular protein localization|regulation of cellular ketone metabolic process|response to organic cyclic compound|serine-type peptidase activity|cellular protein metabolic process|gene expression|protein import|regulation of lipid metabolic process|purine nucleotide binding|lipid modification|protein transmembrane transport|nucleus|regulation of fatty acid metabolic process|cellular protein catabolic process|serine-type endopeptidase activity|protein targeting to peroxisome|protein localization to organelle|protein processing|peroxisome|ATP binding|carboxylic acid catabolic process|adenyl nucleotide binding|peroxisomal matrix|protein targeting|intracellular protein transport|proteolysis involved in cellular protein catabolic process|intracellular protein transmembrane transport|regulation of fatty acid beta-oxidation|endopeptidase activity|establishment of protein localization to peroxisome|carboxylic acid metabolic process|fatty acid catabolic process|fatty acid oxidation|pyrophosphatase activity|ATP-dependent peptidase activity|fatty acid beta-oxidation|regulation of fatty acid oxidation|nucleoside-triphosphatase activity|protein import into peroxisome matrix|monocarboxylic acid metabolic process|misfolded or incompletely synthesized protein catabolic process|ATPase activity|ATPase activity, coupled - - - - 16:48244296-48363122 323 426 778 2075 2205 2085 1.47463754601227 1.76755205466628 3.20240455884356 8.48785419797631 8.25959361176337 8.921074366409 2.14819805317404 8.55617405871623 -1.99383882286449 1.34400657945094e-14 5.85751422232531e-13 DOWN ENSG00000175193 PARL presenilin associated, rhomboid-like [Source:HGNC Symbol;Acc:HGNC:18253] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0023051|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0031090|GO:0019222|GO:0060341|GO:0010506|GO:0019866|GO:0006810|GO:0010941|GO:0009991|GO:0051128|GO:0033554|GO:0043231|GO:0008233|GO:0005737|GO:0032880|GO:0072593|GO:0009966|GO:0031966|GO:0045184|GO:0060548|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0000422|GO:0009968|GO:0051649|GO:0008219|GO:0016236|GO:0016021|GO:0019538|GO:0031323|GO:0006996|GO:0017171|GO:0005740|GO:1903008|GO:0072594|GO:0007005|GO:0043069|GO:2001234|GO:0032386|GO:0051223|GO:0051604|GO:0015031|GO:1903146|GO:2000377|GO:0070201|GO:0046907|GO:0016241|GO:0005743|GO:0006508|GO:0005739|GO:0034613|GO:0012501|GO:0008236|GO:0035556|GO:0033043|GO:0010467|GO:1902532|GO:0006626|GO:0051246|GO:1903827|GO:1902531|GO:0031667|GO:0005634|GO:0043067|GO:0097190|GO:0090201|GO:0004252|GO:0097193|GO:2001242|GO:0033365|GO:0033157|GO:0016485|GO:0006839|GO:0030162|GO:2001243|GO:0008637|GO:0006605|GO:0072655|GO:0033619|GO:0010823|GO:0016482|GO:0006886|GO:0004175|GO:0010821|GO:0001836|GO:0042981|GO:0043066|GO:1903214|GO:0006915|GO:1903533|GO:0070585 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|regulation of signaling|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|organelle membrane|regulation of metabolic process|regulation of cellular localization|regulation of autophagy|organelle inner membrane|transport|regulation of cell death|response to extracellular stimulus|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|regulation of protein localization|reactive oxygen species metabolic process|regulation of signal transduction|mitochondrial membrane|establishment of protein localization|negative regulation of cell death|regulation of cell communication|protein localization|cell communication|signal transduction|mitophagy|negative regulation of signal transduction|establishment of localization in cell|cell death|macroautophagy|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|organelle organization|serine hydrolase activity|mitochondrial envelope|organelle disassembly|establishment of protein localization to organelle|mitochondrion organization|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of intracellular transport|regulation of protein transport|protein maturation|protein transport|regulation of mitophagy|regulation of reactive oxygen species metabolic process|regulation of establishment of protein localization|intracellular transport|regulation of macroautophagy|mitochondrial inner membrane|proteolysis|mitochondrion|cellular protein localization|programmed cell death|serine-type peptidase activity|intracellular signal transduction|regulation of organelle organization|gene expression|negative regulation of intracellular signal transduction|protein targeting to mitochondrion|regulation of protein metabolic process|regulation of cellular protein localization|regulation of intracellular signal transduction|response to nutrient levels|nucleus|regulation of programmed cell death|apoptotic signaling pathway|negative regulation of release of cytochrome c from mitochondria|serine-type endopeptidase activity|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|protein localization to organelle|regulation of intracellular protein transport|protein processing|mitochondrial transport|regulation of proteolysis|negative regulation of intrinsic apoptotic signaling pathway|apoptotic mitochondrial changes|protein targeting|establishment of protein localization to mitochondrion|membrane protein proteolysis|negative regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|endopeptidase activity|regulation of mitochondrion organization|release of cytochrome c from mitochondria|regulation of apoptotic process|negative regulation of apoptotic process|regulation of protein targeting to mitochondrion|apoptotic process|regulation of protein targeting|protein localization to mitochondrion - - - - 3:183829385-183884933 229 262 330 1055 1052 780 4.0741317696283 4.23623570038134 5.29331568714425 16.8170330240651 15.3561690961577 13.0053744807991 4.53456105238463 15.059525533674 -1.73164150801286 1.35418617017305e-14 5.8932760822662e-13 DOWN ENSG00000071189 SNX13 sorting nexin 13 [Source:HGNC Symbol;Acc:HGNC:21335] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0023051|GO:0043227|GO:0008289|GO:0023057|GO:0009893|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0019222|GO:0006810|GO:0043168|GO:0005543|GO:0043231|GO:0005737|GO:0009966|GO:0045184|GO:0010646|GO:0043085|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0051649|GO:0010008|GO:0050790|GO:0016021|GO:0005768|GO:0051345|GO:0005769|GO:0035091|GO:0015031|GO:0046907|GO:0031901|GO:0034613|GO:0043087|GO:0006886|GO:0043547|GO:1901981|GO:0032266 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|ion binding|cellular localization|regulation of signaling|membrane-bounded organelle|lipid binding|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|regulation of metabolic process|transport|anion binding|phospholipid binding|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|establishment of protein localization|regulation of cell communication|positive regulation of catalytic activity|protein localization|cell communication|signal transduction|negative regulation of signal transduction|establishment of localization in cell|endosome membrane|regulation of catalytic activity|integral component of membrane|endosome|positive regulation of hydrolase activity|early endosome|phosphatidylinositol binding|protein transport|intracellular transport|early endosome membrane|cellular protein localization|regulation of GTPase activity|intracellular protein transport|positive regulation of GTPase activity|phosphatidylinositol phosphate binding|phosphatidylinositol-3-phosphate binding - - - - 7:17790761-17940501 232 308 471 1179 1181 1408 0.74874449016156 0.903389407808806 1.37050346219473 3.40922951702173 3.12725102703318 4.25869309573838 1.0075457867217 3.59839121326443 -1.83650664158045 1.43073474494303e-14 6.21734426135798e-13 DOWN ENSG00000182022 CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 [Source:HGNC Symbol;Acc:HGNC:18137] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006082|GO:0043168|GO:0044281|GO:0001882|GO:0043231|GO:0005737|GO:0005975|GO:0050656|GO:0000166|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0034645|GO:0001883|GO:0030204|GO:0009100|GO:0032549|GO:0005996|GO:1901137|GO:0008146|GO:0000139|GO:0017076|GO:0009059|GO:0016051|GO:0019318|GO:0009101|GO:0030206|GO:0030554|GO:0050659|GO:0050650|GO:0006024|GO:0006029|GO:0030203|GO:0019319|GO:0030166 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|organic acid metabolic process|anion binding|small molecule metabolic process|nucleoside binding|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|3'-phosphoadenosine 5'-phosphosulfate binding|nucleotide binding|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|cellular macromolecule biosynthetic process|purine nucleoside binding|chondroitin sulfate metabolic process|glycoprotein metabolic process|ribonucleoside binding|monosaccharide metabolic process|carbohydrate derivative biosynthetic process|sulfotransferase activity|Golgi membrane|purine nucleotide binding|macromolecule biosynthetic process|carbohydrate biosynthetic process|hexose metabolic process|glycoprotein biosynthetic process|chondroitin sulfate biosynthetic process|adenyl nucleotide binding|N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity|chondroitin sulfate proteoglycan biosynthetic process|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|glycosaminoglycan metabolic process|hexose biosynthetic process|proteoglycan biosynthetic process K08106 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase[2.8.2.33] hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human) 10:124007666-124093607 212 257 352 885 983 920 1.39681857446431 1.53892204349653 2.09102771680882 5.22449357952621 5.31403774808781 5.68094002173011 1.67558944492322 5.40649044978138 -1.69002369054411 1.43649237411056e-14 6.23329118265941e-13 DOWN ENSG00000139433 GLTP glycolipid transfer protein [Source:HGNC Symbol;Acc:HGNC:24867] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0044255|GO:0017089|GO:0006810|GO:0044281|GO:0031982|GO:0005737|GO:0005319|GO:0006629|GO:0070062|GO:0051861|GO:0010876|GO:0005829|GO:0006665|GO:0006643|GO:0006869|GO:1901264|GO:0006687|GO:0006664|GO:0046836 transporter activity|cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|lipid binding|intracellular|protein binding|cellular lipid metabolic process|glycolipid transporter activity|transport|small molecule metabolic process|vesicle|cytoplasm|lipid transporter activity|lipid metabolic process|extracellular exosome|glycolipid binding|lipid localization|cytosol|sphingolipid metabolic process|membrane lipid metabolic process|lipid transport|carbohydrate derivative transport|glycosphingolipid metabolic process|glycolipid metabolic process|glycolipid transport - - - - 12:109850943-109880488 134 127 156 572 492 726 2.08324423333987 1.79439951399993 2.18661738858733 7.96761086705068 6.27577719681924 10.5779155131336 2.02142037864238 8.27376785900117 -2.03317510108954 1.49201140097047e-14 6.46480527787699e-13 DOWN ENSG00000018510 AGPS alkylglycerone phosphate synthase [Source:HGNC Symbol;Acc:HGNC:327] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0031090|GO:0044255|GO:0043168|GO:0044281|GO:0016614|GO:0043231|GO:0005737|GO:0006629|GO:0050662|GO:0016765|GO:0000166|GO:0044249|GO:0055114|GO:0005730|GO:0006662|GO:0050660|GO:0031981|GO:0008609|GO:0005739|GO:0008611|GO:0008610|GO:0005634|GO:0046485|GO:0005778|GO:0005777|GO:0005782|GO:0071949 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|biosynthetic process|intracellular|protein binding|transferase activity|organelle membrane|cellular lipid metabolic process|anion binding|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|coenzyme binding|transferase activity, transferring alkyl or aryl (other than methyl) groups|nucleotide binding|cellular biosynthetic process|oxidation-reduction process|nucleolus|glycerol ether metabolic process|flavin adenine dinucleotide binding|nuclear lumen|alkylglycerone-phosphate synthase activity|mitochondrion|ether lipid biosynthetic process|lipid biosynthetic process|nucleus|ether lipid metabolic process|peroxisomal membrane|peroxisome|peroxisomal matrix|FAD binding K00803 alkyldihydroxyacetonephosphate synthase[2.5.1.26] hsa01100|hsa04146|hsa00565 Metabolic pathways - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|Ether lipid metabolism - Homo sapiens (human) 2:177392644-177543836 635 922 1089 3128 3479 2562 4.98699896657878 6.58076533431973 7.71094293823617 22.0105072343873 22.4175404399425 18.8570418248401 6.42623574637823 21.0950298330566 -1.71485731570751 1.55825898100668e-14 6.74206719115557e-13 DOWN ENSG00000172059 KLF11 Kruppel-like factor 11 [Source:HGNC Symbol;Acc:HGNC:11811] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0042127|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0010941|GO:0003676|GO:0034641|GO:0046483|GO:0010942|GO:0043231|GO:0043169|GO:0000981|GO:0009890|GO:0006139|GO:0008219|GO:0008285|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:1903047|GO:0010629|GO:0051252|GO:0044770|GO:0000278|GO:0012501|GO:0010467|GO:0009059|GO:0043068|GO:0016070|GO:0005634|GO:0043067|GO:0000083|GO:0000975|GO:0043065|GO:0045892|GO:0032774|GO:0044772|GO:2001141|GO:1902679|GO:0042981|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000082|GO:0000122 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell death|negative regulation of cell proliferation|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|mitotic cell cycle process|negative regulation of gene expression|regulation of RNA metabolic process|cell cycle phase transition|mitotic cell cycle|programmed cell death|gene expression|macromolecule biosynthetic process|positive regulation of programmed cell death|RNA metabolic process|nucleus|regulation of programmed cell death|regulation of transcription involved in G1/S transition of mitotic cell cycle|regulatory region DNA binding|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of apoptotic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter - - - - 2:10042849-10054836 763 805 1058 248 277 357 10.2745466048037 9.85177411909852 12.8451253674711 2.99218322878329 3.06046023231345 4.50542029380587 10.9904820304578 3.51935458496754 1.64287188054795 1.58802880412099e-14 6.86092791870161e-13 UP ENSG00000095261 PSMD5 proteasome 26S subunit, non-ATPase 5 [Source:HGNC Symbol;Acc:HGNC:9563] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0019882|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0002757|GO:0051726|GO:0007049|GO:0006935|GO:0045087|GO:0048468|GO:0019884|GO:0022402|GO:0010941|GO:0006082|GO:0007275|GO:0034641|GO:0044281|GO:0006952|GO:0031325|GO:0033554|GO:0022607|GO:0045786|GO:0043231|GO:0010243|GO:0005737|GO:0006520|GO:0002218|GO:0006928|GO:0009966|GO:0005838|GO:0000502|GO:0045787|GO:0060548|GO:0010646|GO:0043085|GO:0022624|GO:0050776|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0009968|GO:0042180|GO:0008540|GO:0009725|GO:0008219|GO:0050790|GO:0048002|GO:0030030|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0043487|GO:0010033|GO:0031324|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0030111|GO:0000902|GO:0005829|GO:0045732|GO:0031175|GO:0010468|GO:0000075|GO:0030178|GO:0090068|GO:0007166|GO:1903047|GO:0043412|GO:0002758|GO:0034097|GO:0030163|GO:0043069|GO:0009308|GO:0044770|GO:0044265|GO:1901652|GO:0007050|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0006521|GO:0002429|GO:0031981|GO:0051351|GO:0007346|GO:0043434|GO:0044344|GO:0010564|GO:0051247|GO:0045930|GO:0070848|GO:0006508|GO:0005654|GO:0002764|GO:0006461|GO:0002474|GO:0010565|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0042176|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030177|GO:0030154|GO:0048858|GO:0072395|GO:1902531|GO:0032870|GO:0005634|GO:0043067|GO:0045089|GO:0006974|GO:0045088|GO:0043488|GO:0010948|GO:0048666|GO:0030182|GO:0007411|GO:0016055|GO:0044257|GO:0019221|GO:0042590|GO:0031401|GO:0008543|GO:0090090|GO:0034622|GO:0071156|GO:0010498|GO:0051436|GO:1901653|GO:0043408|GO:0060828|GO:0007093|GO:0072331|GO:0042770|GO:0038061|GO:1903364|GO:0044772|GO:0030162|GO:0051444|GO:0043623|GO:0045862|GO:0051439|GO:0071363|GO:0016310|GO:0010608|GO:0002768|GO:0044774|GO:0038179|GO:0000077|GO:0061564|GO:1901990|GO:0051603|GO:0007167|GO:0006576|GO:0071375|GO:0043410|GO:0042981|GO:0071345|GO:0043066|GO:0019752|GO:0032868|GO:1901987|GO:0051438|GO:0034612|GO:0051443|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050851|GO:0090263|GO:0048812|GO:0043549|GO:0006915|GO:0044773|GO:1901991|GO:0071158|GO:0033674|GO:0048011|GO:0000186|GO:2000045|GO:0007265|GO:0002223|GO:0045859|GO:1903052|GO:0045860|GO:0043248|GO:0007409|GO:0044819|GO:0019941|GO:0006468|GO:0048699|GO:0071356|GO:0060070|GO:0044783|GO:0043405|GO:0042325|GO:0002479|GO:0001932|GO:1902806|GO:0032869|GO:0038093|GO:2000134|GO:0000082|GO:0033209|GO:0001934|GO:0050852|GO:0031571|GO:0042327|GO:1902807|GO:0006977|GO:0030330|GO:0051437|GO:0043161|GO:0072422|GO:0006595|GO:0007169|GO:0032446|GO:0048010|GO:0072431|GO:0006511|GO:0031398|GO:2000058|GO:0038095|GO:0031396|GO:0070682|GO:0031397|GO:2000060|GO:0071900|GO:0032147|GO:0008286|GO:0031145|GO:0038127|GO:0007173|GO:0042787|GO:0016567|GO:0000209 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|antigen processing and presentation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|anatomical structure development|regulation of metabolic process|viral process|immune response-activating signal transduction|regulation of cell cycle|cell cycle|chemotaxis|innate immune response|cell development|antigen processing and presentation of exogenous antigen|cell cycle process|regulation of cell death|organic acid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|positive regulation of cellular metabolic process|cellular response to stress|cellular component assembly|negative regulation of cell cycle|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|activation of innate immune response|movement of cell or subcellular component|regulation of signal transduction|proteasome regulatory particle|proteasome complex|positive regulation of cell cycle|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|proteasome accessory complex|regulation of immune response|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|negative regulation of signal transduction|cellular ketone metabolic process|proteasome regulatory particle, base subcomplex|response to hormone|cell death|regulation of catalytic activity|antigen processing and presentation of peptide antigen|cell projection organization|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of RNA stability|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|positive regulation of protein catabolic process|neuron projection development|regulation of gene expression|cell cycle checkpoint|negative regulation of Wnt signaling pathway|positive regulation of cell cycle process|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|innate immune response-activating signal transduction|response to cytokine|protein catabolic process|negative regulation of programmed cell death|amine metabolic process|cell cycle phase transition|cellular macromolecule catabolic process|response to peptide|cell cycle arrest|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of cellular amino acid metabolic process|immune response-activating cell surface receptor signaling pathway|nuclear lumen|positive regulation of ligase activity|regulation of mitotic cell cycle|response to peptide hormone|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|response to growth factor|proteolysis|nucleoplasm|immune response-regulating signaling pathway|protein complex assembly|antigen processing and presentation of peptide antigen via MHC class I|regulation of cellular ketone metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|cell differentiation|cell projection morphogenesis|signal transduction involved in cell cycle checkpoint|regulation of intracellular signal transduction|cellular response to hormone stimulus|nucleus|regulation of programmed cell death|positive regulation of innate immune response|cellular response to DNA damage stimulus|regulation of innate immune response|regulation of mRNA stability|negative regulation of cell cycle process|neuron development|neuron differentiation|axon guidance|Wnt signaling pathway|cellular protein catabolic process|cytokine-mediated signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|cellular macromolecular complex assembly|regulation of cell cycle arrest|proteasomal protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|cellular response to peptide|regulation of MAPK cascade|regulation of canonical Wnt signaling pathway|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|NIK/NF-kappaB signaling|positive regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of proteolysis|negative regulation of ubiquitin-protein transferase activity|cellular protein complex assembly|positive regulation of proteolysis|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|cellular response to growth factor stimulus|phosphorylation|posttranscriptional regulation of gene expression|immune response-regulating cell surface receptor signaling pathway|mitotic DNA integrity checkpoint|neurotrophin signaling pathway|DNA damage checkpoint|axon development|regulation of mitotic cell cycle phase transition|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|cellular biogenic amine metabolic process|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|carboxylic acid metabolic process|response to insulin|regulation of cell cycle phase transition|regulation of ubiquitin-protein transferase activity|response to tumor necrosis factor|positive regulation of ubiquitin-protein transferase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|antigen receptor-mediated signaling pathway|positive regulation of canonical Wnt signaling pathway|neuron projection morphogenesis|regulation of kinase activity|apoptotic process|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|regulation of G1/S transition of mitotic cell cycle|Ras protein signal transduction|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|positive regulation of proteolysis involved in cellular protein catabolic process|positive regulation of protein kinase activity|proteasome assembly|axonogenesis|mitotic G1/S transition checkpoint|modification-dependent protein catabolic process|protein phosphorylation|generation of neurons|cellular response to tumor necrosis factor|canonical Wnt signaling pathway|G1 DNA damage checkpoint|regulation of MAP kinase activity|regulation of phosphorylation|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|cellular response to insulin stimulus|Fc receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|tumor necrosis factor-mediated signaling pathway|positive regulation of protein phosphorylation|T cell receptor signaling pathway|mitotic G1 DNA damage checkpoint|positive regulation of phosphorylation|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|proteasome-mediated ubiquitin-dependent protein catabolic process|signal transduction involved in DNA damage checkpoint|polyamine metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|signal transduction involved in mitotic G1 DNA damage checkpoint|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Fc-epsilon receptor signaling pathway|regulation of protein ubiquitination|proteasome regulatory particle assembly|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 9:120815496-120842984 461 576 623 1703 2040 1604 5.15730877596936 5.85632561234537 6.28383548860819 17.0700568259464 18.7249466210687 16.8172802865231 5.76582329230764 17.5374279111794 -1.60483864583773 1.60740237951988e-14 6.93459402285931e-13 DOWN ENSG00000121879 PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [Source:HGNC Symbol;Acc:HGNC:8975] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0042995|GO:0032259|GO:0097159|GO:0048523|GO:0050794|GO:0045321|GO:0006807|GO:0006950|GO:0071704|GO:0050900|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0006914|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0031252|GO:0009058|GO:0030234|GO:0002684|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0002757|GO:0002250|GO:0044255|GO:0050817|GO:0016337|GO:0006935|GO:0045087|GO:0006725|GO:0009888|GO:0050867|GO:0006810|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0048513|GO:0070489|GO:0034641|GO:0043168|GO:0015980|GO:0008047|GO:0044281|GO:0006952|GO:0030155|GO:0001882|GO:0016772|GO:0019637|GO:0031325|GO:0046483|GO:0033554|GO:0098609|GO:0010243|GO:0005737|GO:0003012|GO:0009611|GO:0005942|GO:0005975|GO:0006928|GO:0035264|GO:0042592|GO:0002696|GO:0001775|GO:0030027|GO:0019725|GO:0048871|GO:0060548|GO:0006139|GO:0043085|GO:0050776|GO:0001525|GO:0046649|GO:0050865|GO:0007154|GO:0006629|GO:0016477|GO:0007165|GO:0050778|GO:0000422|GO:0048638|GO:0043560|GO:0045785|GO:0009725|GO:0040014|GO:0008219|GO:0016236|GO:0050790|GO:0031295|GO:0000166|GO:0006091|GO:0019207|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0048732|GO:0050878|GO:0003013|GO:0006996|GO:0055114|GO:0071774|GO:0016192|GO:0051249|GO:0032268|GO:0006909|GO:0005829|GO:0009743|GO:0010468|GO:0006936|GO:0090132|GO:0008654|GO:0030168|GO:1901215|GO:0046486|GO:1903008|GO:0007166|GO:2000653|GO:0035639|GO:0000423|GO:0001944|GO:0043412|GO:0072358|GO:0007005|GO:0019887|GO:0043069|GO:0048878|GO:0007596|GO:0001883|GO:0034109|GO:0070997|GO:1901652|GO:0001889|GO:0071417|GO:0001667|GO:0051347|GO:0036211|GO:0006306|GO:0042060|GO:0006954|GO:0032549|GO:0055082|GO:0051251|GO:0002429|GO:0022407|GO:0060326|GO:0043434|GO:1990234|GO:0007599|GO:0044344|GO:0007159|GO:0005996|GO:0051247|GO:0070848|GO:0071514|GO:0006259|GO:0002764|GO:0016301|GO:1901214|GO:0032270|GO:0042110|GO:0012501|GO:0043467|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0097009|GO:0008610|GO:0019209|GO:0071310|GO:0017076|GO:0045333|GO:0051246|GO:0022409|GO:0061448|GO:0030258|GO:0072359|GO:0016773|GO:0008015|GO:0032870|GO:0043067|GO:0038096|GO:0006644|GO:0060612|GO:0006941|GO:0071322|GO:0043491|GO:0019318|GO:0044030|GO:0031401|GO:0050863|GO:0001678|GO:0008543|GO:1901653|GO:0046474|GO:0043523|GO:0035004|GO:0005524|GO:0060047|GO:0034284|GO:0071363|GO:0030554|GO:0016310|GO:0002768|GO:0038179|GO:0034112|GO:0006304|GO:0070486|GO:0005943|GO:0048017|GO:0043457|GO:0007167|GO:0016307|GO:0030295|GO:0071375|GO:0010631|GO:0042981|GO:0043066|GO:0004672|GO:0032868|GO:0051402|GO:0046834|GO:0002431|GO:0043524|GO:0006897|GO:0006464|GO:0050870|GO:0098779|GO:0050851|GO:0043549|GO:0006650|GO:0006915|GO:0033500|GO:1903039|GO:0033674|GO:0048011|GO:0071333|GO:0042593|GO:0044346|GO:0045859|GO:0016303|GO:0048015|GO:0045860|GO:0046854|GO:0046488|GO:2000269|GO:0006468|GO:2000209|GO:0006006|GO:0046934|GO:0006661|GO:0060048|GO:0042325|GO:0001932|GO:0032869|GO:0018193|GO:0038093|GO:0043276|GO:0004674|GO:0001934|GO:2000270|GO:0050852|GO:0043542|GO:0071593|GO:0042327|GO:2000811|GO:0007169|GO:0035005|GO:0048010|GO:0036092|GO:0038094|GO:0044029|GO:0033138|GO:0038095|GO:0009749|GO:0018105|GO:0014065|GO:0033135|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0038028 locomotion|developmental process|growth|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|cell projection|methylation|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|leukocyte activation|nitrogen compound metabolic process|response to stress|organic substance metabolic process|leukocyte migration|catabolic process|ion binding|immune response|cellular metabolic process|autophagy|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|cell leading edge|biosynthetic process|enzyme regulator activity|positive regulation of immune system process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|immune response-activating signal transduction|adaptive immune response|cellular lipid metabolic process|coagulation|single organismal cell-cell adhesion|chemotaxis|innate immune response|cellular aromatic compound metabolic process|tissue development|positive regulation of cell activation|transport|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|enzyme activator activity|small molecule metabolic process|defense response|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cell-cell adhesion|response to organonitrogen compound|cytoplasm|muscle system process|response to wounding|phosphatidylinositol 3-kinase complex|carbohydrate metabolic process|movement of cell or subcellular component|multicellular organism growth|homeostatic process|positive regulation of leukocyte activation|cell activation|lamellipodium|cellular homeostasis|multicellular organismal homeostasis|negative regulation of cell death|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|angiogenesis|lymphocyte activation|regulation of cell activation|cell communication|lipid metabolic process|cell migration|signal transduction|positive regulation of immune response|mitophagy|regulation of developmental growth|insulin receptor substrate binding|positive regulation of cell adhesion|response to hormone|regulation of multicellular organism growth|cell death|macroautophagy|regulation of catalytic activity|T cell costimulation|nucleotide binding|generation of precursor metabolites and energy|kinase regulator activity|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|gland development|regulation of body fluid levels|circulatory system process|organelle organization|oxidation-reduction process|response to fibroblast growth factor|vesicle-mediated transport|regulation of lymphocyte activation|regulation of cellular protein metabolic process|phagocytosis|cytosol|response to carbohydrate|regulation of gene expression|muscle contraction|epithelium migration|phospholipid biosynthetic process|platelet activation|negative regulation of neuron death|glycerolipid metabolic process|organelle disassembly|cell surface receptor signaling pathway|regulation of genetic imprinting|purine ribonucleoside triphosphate binding|macromitophagy|vasculature development|macromolecule modification|cardiovascular system development|mitochondrion organization|protein kinase regulator activity|negative regulation of programmed cell death|chemical homeostasis|blood coagulation|purine nucleoside binding|homotypic cell-cell adhesion|neuron death|response to peptide|liver development|cellular response to organonitrogen compound|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|DNA methylation|wound healing|inflammatory response|ribonucleoside binding|cellular chemical homeostasis|positive regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|regulation of cell-cell adhesion|cell chemotaxis|response to peptide hormone|transferase complex|hemostasis|cellular response to fibroblast growth factor stimulus|leukocyte cell-cell adhesion|monosaccharide metabolic process|positive regulation of protein metabolic process|response to growth factor|genetic imprinting|DNA metabolic process|immune response-regulating signaling pathway|kinase activity|regulation of neuron death|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|energy homeostasis|lipid biosynthetic process|kinase activator activity|cellular response to organic substance|purine nucleotide binding|cellular respiration|regulation of protein metabolic process|positive regulation of cell-cell adhesion|connective tissue development|lipid modification|circulatory system development|phosphotransferase activity, alcohol group as acceptor|blood circulation|cellular response to hormone stimulus|regulation of programmed cell death|Fc-gamma receptor signaling pathway involved in phagocytosis|phospholipid metabolic process|adipose tissue development|striated muscle contraction|cellular response to carbohydrate stimulus|protein kinase B signaling|hexose metabolic process|regulation of DNA methylation|positive regulation of protein modification process|regulation of T cell activation|cellular glucose homeostasis|fibroblast growth factor receptor signaling pathway|cellular response to peptide|glycerophospholipid biosynthetic process|regulation of neuron apoptotic process|phosphatidylinositol 3-kinase activity|ATP binding|heart contraction|response to monosaccharide|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|positive regulation of homotypic cell-cell adhesion|DNA modification|leukocyte aggregation|phosphatidylinositol 3-kinase complex, class IA|inositol lipid-mediated signaling|regulation of cellular respiration|enzyme linked receptor protein signaling pathway|phosphatidylinositol phosphate kinase activity|protein kinase activator activity|cellular response to peptide hormone stimulus|epithelial cell migration|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|response to insulin|neuron apoptotic process|lipid phosphorylation|Fc receptor mediated stimulatory signaling pathway|negative regulation of neuron apoptotic process|endocytosis|cellular protein modification process|positive regulation of T cell activation|mitophagy in response to mitochondrial depolarization|antigen receptor-mediated signaling pathway|regulation of kinase activity|glycerophospholipid metabolic process|apoptotic process|carbohydrate homeostasis|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|cellular response to glucose stimulus|glucose homeostasis|fibroblast apoptotic process|regulation of protein kinase activity|1-phosphatidylinositol-3-kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|phosphatidylinositol phosphorylation|phosphatidylinositol metabolic process|regulation of fibroblast apoptotic process|protein phosphorylation|regulation of anoikis|glucose metabolic process|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|phosphatidylinositol biosynthetic process|cardiac muscle contraction|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|anoikis|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|negative regulation of fibroblast apoptotic process|T cell receptor signaling pathway|endothelial cell migration|lymphocyte aggregation|positive regulation of phosphorylation|negative regulation of anoikis|transmembrane receptor protein tyrosine kinase signaling pathway|1-phosphatidylinositol-4-phosphate 3-kinase activity|vascular endothelial growth factor receptor signaling pathway|phosphatidylinositol-3-phosphate biosynthetic process|Fc-gamma receptor signaling pathway|hypomethylation of CpG island|positive regulation of peptidyl-serine phosphorylation|Fc-epsilon receptor signaling pathway|response to glucose|peptidyl-serine phosphorylation|phosphatidylinositol 3-kinase signaling|regulation of peptidyl-serine phosphorylation|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway via phosphatidylinositol 3-kinase K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase[2.7.1.153] hsa05200|hsa04151|hsa05166|hsa05206|hsa04014|hsa04810|hsa04015|hsa05203|hsa05205|hsa04510|hsa05169|hsa04024|hsa04062|hsa05164|hsa04022|hsa04630|hsa04921|hsa04932|hsa04261|hsa05161|hsa04072|hsa04550|hsa04210|hsa04910|hsa05162|hsa04650|hsa04068|hsa05160|hsa04380|hsa04152|hsa04611|hsa04722|hsa04071|hsa05145|hsa04670|hsa04919|hsa04725|hsa04668|hsa04931|hsa04620|hsa05142|hsa04660|hsa04066|hsa05231|hsa04933|hsa04915|hsa04750|hsa04070|hsa05146|hsa04914|hsa04211|hsa04666|hsa05215|hsa04012|hsa05222|hsa05100|hsa05220|hsa04662|hsa04917|hsa05218|hsa00562|hsa05230|hsa04664|hsa05211|hsa05212|hsa05214|hsa04213|hsa05210|hsa04370|hsa04150|hsa05221|hsa04923|hsa05223|hsa05213|hsa04930|hsa04973|hsa04960 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Influenza A - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Measles - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Melanoma - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Glioma - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Regulation of lipolysis in adipocytes - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Type II diabetes mellitus - Homo sapiens (human)|Carbohydrate digestion and absorption - Homo sapiens (human)|Aldosterone-regulated sodium reabsorption - Homo sapiens (human) 3:179148114-179240093 229 291 406 941 1120 1136 1.5882682533623 1.83426172464625 2.53880004187943 5.84756962244848 6.37344271820178 7.38406275062669 1.98711000662933 6.53502503042565 -1.71752101928069 1.72243593721596e-14 7.42014465651446e-13 DOWN ENSG00000162980 ARL5A ADP ribosylation factor like GTPase 5A [Source:HGNC Symbol;Acc:HGNC:696] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0005622|GO:0043168|GO:0001882|GO:0007154|GO:0007165|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0035556|GO:0017076|GO:0032561|GO:0005525|GO:0007264|GO:0019001 signaling|cell|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|intracellular|anion binding|nucleoside binding|cell communication|signal transduction|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding - - - - 2:151788984-151828492 354 425 459 1236 1521 1172 2.89422954007519 3.15789803609135 3.38342097323434 9.05410367260215 10.2029636559061 8.98019242883045 3.14518284980029 9.4124199191129 -1.58142179265777 1.74781700304903e-14 7.51863527507574e-13 DOWN ENSG00000133640 LRRIQ1 leucine-rich repeats and IQ motif containing 1 [Source:HGNC Symbol;Acc:HGNC:25708] GO:0005488|GO:0005515 binding|protein binding - - - - 12:85036314-85263224 3 3 2 37 49 47 0.0233634763671228 0.0212342944622499 0.0140418432401395 0.258145681322635 0.313064465357295 0.343004528099423 0.0195465380231707 0.304738224926451 -3.96258546329244 1.8096783009418e-14 7.77354474767142e-13 DOWN ENSG00000196449 YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing [Source:HGNC Symbol;Acc:HGNC:28905] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0051051|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0016772|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0006450|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0043412|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0016779|GO:0016070|GO:0043043|GO:0000049|GO:0070525|GO:0006396|GO:0034660|GO:0010608|GO:0009451|GO:0006412|GO:0003725|GO:0006417|GO:0006414|GO:0006400|GO:0002949|GO:0006399|GO:0008033 cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|negative regulation of transport|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|regulation of translational fidelity|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|macromolecule modification|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|peptide biosynthetic process|tRNA binding|tRNA threonylcarbamoyladenosine metabolic process|RNA processing|ncRNA metabolic process|posttranscriptional regulation of gene expression|RNA modification|translation|double-stranded RNA binding|regulation of translation|translational elongation|tRNA modification|tRNA threonylcarbamoyladenosine modification|tRNA metabolic process|tRNA processing - - - - 1:37802944-37808185 1355 1399 847 355 375 283 52.4909366970505 49.2541220605651 29.5830092834671 12.3217225169703 11.9191099044934 10.2744759006887 43.7760226803609 11.5051027740508 1.92786701171214 1.83935572889085e-14 7.88967326584879e-13 UP ENSG00000165591 FAAH2 fatty acid amide hydrolase 2 [Source:HGNC Symbol;Acc:HGNC:26440] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0016787|GO:0031224|GO:0016874|GO:0005622|GO:0044255|GO:0006082|GO:0044281|GO:0006629|GO:0016021|GO:0016884|GO:0006631|GO:0005811|GO:0006690|GO:0033559|GO:0001676|GO:0019369|GO:0019752|GO:0032787 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|hydrolase activity|intrinsic component of membrane|ligase activity|intracellular|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|lipid metabolic process|integral component of membrane|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid metabolic process|lipid particle|icosanoid metabolic process|unsaturated fatty acid metabolic process|long-chain fatty acid metabolic process|arachidonic acid metabolic process|carboxylic acid metabolic process|monocarboxylic acid metabolic process - - - - X:57286706-57489196 14 9 28 133 120 165 0.383405397686105 0.224009347026518 0.691335155847557 3.26340103165111 2.69630855593409 4.23479976987268 0.43291663352006 3.39816978581929 -2.97259679904814 1.85316370449585e-14 7.93749630330259e-13 DOWN ENSG00000186522 SEPT10 septin 10 [Source:HGNC Symbol;Acc:HGNC:14349] GO:0005623|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0005622|GO:0005515|GO:0007049|GO:0043168|GO:0001882|GO:0005737|GO:0000166|GO:0051301|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005856|GO:0032561|GO:0005525|GO:0019001 cell|cellular process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|intracellular|protein binding|cell cycle|anion binding|nucleoside binding|cytoplasm|nucleotide binding|cell division|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|cytoskeleton|guanyl ribonucleotide binding|GTP binding|guanyl nucleotide binding - - - - 2:109542982-109614206 185 193 433 993 1619 1836 1.59336888158104 1.5107122520295 3.36237619102188 7.66285628619059 11.4408616531732 14.8199111954618 2.15548577487747 11.3078763782752 -2.39124306971439 1.91530053886356e-14 8.19188857983275e-13 DOWN ENSG00000162783 IER5 immediate early response 5 [Source:HGNC Symbol;Acc:HGNC:5393] - - - - - - 1:181088712-181092899 4740 5020 5110 1811 2016 2052 80.0603294406145 77.0589021924878 77.8169457168771 27.4066009835599 27.9381469335796 32.4821906801993 78.3120591166598 29.2756461991129 1.41953346675805 1.96889801317523e-14 8.40908172894611e-13 UP ENSG00000114948 ADAM23 ADAM metallopeptidase domain 23 [Source:HGNC Symbol;Acc:HGNC:202] GO:0032502|GO:0005623|GO:0016020|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0044877|GO:0071704|GO:0043167|GO:0007155|GO:0071944|GO:0016787|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0007275|GO:0005102|GO:0005887|GO:0043169|GO:0008233|GO:0032403|GO:0050839|GO:0031226|GO:0016021|GO:0019538|GO:0046872|GO:0007417|GO:0005178|GO:0006508|GO:0007399|GO:0008237|GO:0004175|GO:0046914|GO:0008270|GO:0004222 developmental process|cell|membrane|extracellular region|metabolic process|binding|catalytic activity|macromolecular complex binding|organic substance metabolic process|ion binding|cell adhesion|cell periphery|hydrolase activity|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|multicellular organism development|receptor binding|integral component of plasma membrane|cation binding|peptidase activity|protein complex binding|cell adhesion molecule binding|intrinsic component of plasma membrane|integral component of membrane|protein metabolic process|metal ion binding|central nervous system development|integrin binding|proteolysis|nervous system development|metallopeptidase activity|endopeptidase activity|transition metal ion binding|zinc ion binding|metalloendopeptidase activity - - - - 2:206443539-206621130 8 7 16 71 102 90 0.0780831383448766 0.0621003917774743 0.140809829163435 0.620930073072327 0.816874827411465 0.82330519777136 0.093664453095262 0.753703366085051 -3.00842330092748 1.98656521730763e-14 8.47241685678602e-13 DOWN ENSG00000119685 TTLL5 tubulin tyrosine ligase like 5 [Source:HGNC Symbol;Acc:HGNC:19963] GO:0040011|GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0032504|GO:0009058|GO:0016874|GO:0005622|GO:0048856|GO:0005929|GO:0048646|GO:0048609|GO:0006725|GO:0048468|GO:1901360|GO:0034641|GO:0043168|GO:0005874|GO:0001882|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0030317|GO:0006928|GO:0048515|GO:0006139|GO:0007276|GO:0009566|GO:0000166|GO:0030030|GO:0048869|GO:0007288|GO:0044249|GO:0007017|GO:0019538|GO:0007281|GO:0006996|GO:0000902|GO:0005813|GO:0007286|GO:0034645|GO:0048232|GO:0035639|GO:0043412|GO:0007010|GO:0005815|GO:0001883|GO:0035082|GO:0036211|GO:0044782|GO:0032549|GO:0030031|GO:0070925|GO:0042384|GO:0044267|GO:0010467|GO:0032990|GO:0017076|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0000226|GO:0005856|GO:0005634|GO:0060271|GO:0007283|GO:0032774|GO:0005524|GO:0030554|GO:0015630|GO:0001578|GO:0006464|GO:0006351|GO:0018193|GO:0018095 locomotion|developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|ligase activity|intracellular|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|microtubule|nucleoside binding|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|sperm motility|movement of cell or subcellular component|spermatid differentiation|nucleobase-containing compound metabolic process|gamete generation|fertilization|nucleotide binding|cell projection organization|cellular developmental process|sperm axoneme assembly|cellular biosynthetic process|microtubule-based process|protein metabolic process|germ cell development|organelle organization|cell morphogenesis|centrosome|spermatid development|cellular macromolecule biosynthetic process|male gamete generation|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|microtubule organizing center|purine nucleoside binding|axoneme assembly|protein modification process|cilium organization|ribonucleoside binding|cell projection assembly|organelle assembly|cilium assembly|cellular protein metabolic process|gene expression|cell part morphogenesis|purine nucleotide binding|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|microtubule cytoskeleton organization|cytoskeleton|nucleus|cilium morphogenesis|spermatogenesis|RNA biosynthetic process|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|microtubule bundle formation|cellular protein modification process|transcription, DNA-templated|peptidyl-amino acid modification|protein polyglutamylation - - - - 14:75633625-75955078 246 314 517 1217 1376 1338 1.04093148391669 1.20752604252125 1.97238849840756 4.61397983100616 4.7772049528116 5.30606382496562 1.4069486749485 4.89908286959446 -1.79994199502071 2.40922671459296e-14 1.02603501194662e-12 DOWN ENSG00000113360 DROSHA drosha, ribonuclease type III [Source:HGNC Symbol;Acc:HGNC:17904] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051707|GO:0043227|GO:0008289|GO:0009607|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0042802|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0006952|GO:0046483|GO:0098542|GO:0043231|GO:0043169|GO:0046983|GO:0009890|GO:0016458|GO:0006139|GO:0009617|GO:0001530|GO:0044249|GO:0022613|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0005730|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0003723|GO:0031047|GO:0010629|GO:0051252|GO:0044265|GO:0042254|GO:0010628|GO:0032269|GO:0043331|GO:0031981|GO:0004518|GO:0005654|GO:0070877|GO:0014070|GO:0043603|GO:0044267|GO:0010467|GO:0071310|GO:0019439|GO:0051246|GO:0042742|GO:0009059|GO:0016070|GO:0005634|GO:0042803|GO:0016441|GO:0006401|GO:0043043|GO:0070878|GO:0090501|GO:2000628|GO:0006396|GO:0017148|GO:0034660|GO:0071359|GO:0010608|GO:0071407|GO:0006412|GO:0040029|GO:0003725|GO:0030422|GO:0050830|GO:0006417|GO:0004519|GO:0004540|GO:0035196|GO:0050829|GO:0044822|GO:0090305|GO:0035194|GO:0016246|GO:0090502|GO:0004521|GO:0016072|GO:0031054|GO:0035195|GO:0031053|GO:0010586|GO:0004525|GO:0016891|GO:0016075 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|response to other organism|membrane-bounded organelle|lipid binding|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|defense response|heterocycle metabolic process|defense response to other organism|intracellular membrane-bounded organelle|cation binding|protein dimerization activity|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|response to bacterium|lipopolysaccharide binding|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|nucleolus|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|RNA binding|gene silencing by RNA|negative regulation of gene expression|regulation of RNA metabolic process|cellular macromolecule catabolic process|ribosome biogenesis|positive regulation of gene expression|negative regulation of cellular protein metabolic process|response to dsRNA|nuclear lumen|nuclease activity|nucleoplasm|microprocessor complex|response to organic cyclic compound|cellular amide metabolic process|cellular protein metabolic process|gene expression|cellular response to organic substance|aromatic compound catabolic process|regulation of protein metabolic process|defense response to bacterium|macromolecule biosynthetic process|RNA metabolic process|nucleus|protein homodimerization activity|posttranscriptional gene silencing|RNA catabolic process|peptide biosynthetic process|primary miRNA binding|RNA phosphodiester bond hydrolysis|regulation of miRNA metabolic process|RNA processing|negative regulation of translation|ncRNA metabolic process|cellular response to dsRNA|posttranscriptional regulation of gene expression|cellular response to organic cyclic compound|translation|regulation of gene expression, epigenetic|double-stranded RNA binding|production of siRNA involved in RNA interference|defense response to Gram-positive bacterium|regulation of translation|endonuclease activity|ribonuclease activity|production of miRNAs involved in gene silencing by miRNA|defense response to Gram-negative bacterium|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|posttranscriptional gene silencing by RNA|RNA interference|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|rRNA metabolic process|pre-miRNA processing|gene silencing by miRNA|primary miRNA processing|miRNA metabolic process|ribonuclease III activity|endoribonuclease activity, producing 5'-phosphomonoesters|rRNA catabolic process K03685 ribonuclease III[3.1.26.3] hsa05205|hsa03008 Proteoglycans in cancer - Homo sapiens (human)|Ribosome biogenesis in eukaryotes - Homo sapiens (human) 5:31400497-31532196 286 328 329 1177 1362 840 1.48875757277649 1.55171352431634 1.54407327587843 5.48949377061363 5.81705782162515 4.09794740419258 1.52818145765709 5.13483299881045 -1.74850149578302 2.46037121724679e-14 1.0463236797676e-12 DOWN ENSG00000117479 SLC19A2 solute carrier family 19 (thiamine transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:10938] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0022857|GO:0006807|GO:0071704|GO:0051183|GO:0044237|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0015238|GO:0006725|GO:0006810|GO:1901360|GO:0008517|GO:0034641|GO:0042723|GO:0044281|GO:0046483|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0006790|GO:0015234|GO:0042886|GO:0051181|GO:0006811|GO:0035461|GO:0051180|GO:0015403|GO:0072531|GO:0006766|GO:0006820|GO:0015711|GO:0015888|GO:0046942|GO:0071934|GO:0006865|GO:0015884|GO:0006767|GO:0006835 transporter activity|cell|membrane|cellular process|metabolic process|binding|transmembrane transporter activity|nitrogen compound metabolic process|organic substance metabolic process|vitamin transporter activity|cellular metabolic process|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|drug transmembrane transporter activity|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|folic acid transporter activity|cellular nitrogen compound metabolic process|thiamine-containing compound metabolic process|small molecule metabolic process|heterocycle metabolic process|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|sulfur compound metabolic process|thiamine transmembrane transporter activity|amide transport|cofactor transport|ion transport|vitamin transmembrane transport|vitamin transport|thiamine uptake transmembrane transporter activity|pyrimidine-containing compound transmembrane transport|vitamin metabolic process|anion transport|organic anion transport|thiamine transport|carboxylic acid transport|thiamine transmembrane transport|amino acid transport|folic acid transport|water-soluble vitamin metabolic process|dicarboxylic acid transport K14610 solute carrier family 19 (thiamine transporter), member 2/3[-] hsa04977 Vitamin digestion and absorption - Homo sapiens (human) 1:169463909-169486003 594 703 900 247 286 261 6.90058432562458 7.42223744231298 9.42663464169156 2.57095181295546 2.72605258058893 2.84164321938691 7.91648546987637 2.71288253764377 1.54503350362614 2.46806813786126e-14 1.04810392870142e-12 UP ENSG00000165914 TTC7B tetratricopeptide repeat domain 7B [Source:HGNC Symbol;Acc:HGNC:19858] GO:0005488|GO:0005515 binding|protein binding - - - - 14:90524564-90816479 11 8 28 116 134 149 0.0308991471250999 0.020423255366236 0.0709125052638488 0.291951490332168 0.30883573417779 0.392258174997507 0.0407449692517282 0.331015133169155 -3.02220332781773 2.56776844297721e-14 1.08889430535002e-12 DOWN ENSG00000176946 THAP4 THAP domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23187] GO:0005488|GO:0097159|GO:0043167|GO:0003676|GO:0043169|GO:0003677|GO:0046872 binding|organic cyclic compound binding|ion binding|nucleic acid binding|cation binding|DNA binding|metal ion binding - - - - 2:241584405-241637449 231 255 312 954 1126 739 3.35321466077128 3.36410680378013 4.08336101706232 12.4078148171834 13.4108363237735 10.0536221611776 3.60022749387124 11.9574244340448 -1.73174669747702 2.83184866889662e-14 1.1991774490956e-12 DOWN ENSG00000110422 HIPK3 homeodomain interacting protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:4915] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0023057|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0010941|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0009966|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0008219|GO:0050790|GO:0000166|GO:0043086|GO:0044249|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0000165|GO:0032268|GO:0010468|GO:0034645|GO:0035639|GO:0043412|GO:0043069|GO:0051252|GO:0001883|GO:0036211|GO:0032269|GO:0032549|GO:0031981|GO:0031098|GO:0005654|GO:0016301|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:1902532|GO:0017076|GO:0051246|GO:0009059|GO:1902531|GO:0016070|GO:0016773|GO:0005634|GO:0043067|GO:0043408|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0016310|GO:0016604|GO:0032872|GO:0042981|GO:0043066|GO:0004672|GO:0043409|GO:0033673|GO:0006464|GO:0051403|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0009299|GO:0045859|GO:0006469|GO:0046328|GO:0006468|GO:0043407|GO:1903506|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0018193|GO:0042326|GO:0016605|GO:0004674|GO:0001933|GO:0032873|GO:0071901|GO:0018105|GO:0071900|GO:0018107|GO:0043506|GO:0043508|GO:0046329 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|cell death|regulation of catalytic activity|nucleotide binding|negative regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|macromolecule modification|negative regulation of programmed cell death|regulation of RNA metabolic process|purine nucleoside binding|protein modification process|negative regulation of cellular protein metabolic process|ribonucleoside binding|nuclear lumen|stress-activated protein kinase signaling cascade|nucleoplasm|kinase activity|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|negative regulation of intracellular signal transduction|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|regulation of programmed cell death|regulation of MAPK cascade|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|nuclear body|regulation of stress-activated MAPK cascade|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|mRNA transcription|regulation of protein kinase activity|negative regulation of protein kinase activity|regulation of JNK cascade|protein phosphorylation|negative regulation of MAP kinase activity|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|PML body|protein serine/threonine kinase activity|negative regulation of protein phosphorylation|negative regulation of stress-activated MAPK cascade|negative regulation of protein serine/threonine kinase activity|peptidyl-serine phosphorylation|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|regulation of JUN kinase activity|negative regulation of JUN kinase activity|negative regulation of JNK cascade - - - - 11:33256672-33357023 937 1068 1332 3167 3728 3379 5.21277464542308 5.39983479903751 6.68109811749501 15.7861105571746 17.0166190661998 17.6175910196398 5.76456918731853 16.8067735476714 -1.54375809437574 2.85952397024746e-14 1.20918170832532e-12 DOWN ENSG00000163697 APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 [Source:HGNC Symbol;Acc:HGNC:582] GO:0040011|GO:0032502|GO:0040007|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0033218|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0048870|GO:0045926|GO:0009653|GO:0016043|GO:0030427|GO:0043227|GO:0040008|GO:0009605|GO:0031252|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0042277|GO:0006935|GO:0006725|GO:0048468|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0034641|GO:0043062|GO:0046483|GO:0051128|GO:0030426|GO:0010942|GO:0045786|GO:0043231|GO:0030308|GO:0005737|GO:0006928|GO:0043005|GO:0030027|GO:0060548|GO:0006139|GO:0007154|GO:0016477|GO:0007165|GO:0008134|GO:0008219|GO:0030030|GO:0048869|GO:0044249|GO:0001558|GO:0031323|GO:0000902|GO:0031175|GO:0010468|GO:0034645|GO:0043069|GO:0051252|GO:0007050|GO:0000904|GO:0001764|GO:0012501|GO:0035556|GO:0010467|GO:0032990|GO:0007399|GO:0097485|GO:0030198|GO:0009059|GO:0030154|GO:0048858|GO:0043068|GO:0016070|GO:0005634|GO:0043067|GO:0001540|GO:0048666|GO:0030182|GO:0007411|GO:0043065|GO:0032774|GO:2001141|GO:0061564|GO:0042981|GO:0043066|GO:0022008|GO:0048667|GO:0048812|GO:0006351|GO:0006915|GO:0006355|GO:0007409|GO:0048699|GO:1903506 locomotion|developmental process|growth|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|amide binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|cell motility|negative regulation of growth|anatomical structure morphogenesis|cellular component organization|site of polarized growth|membrane-bounded organelle|regulation of growth|response to external stimulus|cell leading edge|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|peptide binding|chemotaxis|cellular aromatic compound metabolic process|cell development|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|cellular nitrogen compound metabolic process|extracellular structure organization|heterocycle metabolic process|regulation of cellular component organization|growth cone|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|negative regulation of cell growth|cytoplasm|movement of cell or subcellular component|neuron projection|lamellipodium|negative regulation of cell death|nucleobase-containing compound metabolic process|cell communication|cell migration|signal transduction|transcription factor binding|cell death|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cell growth|regulation of cellular metabolic process|cell morphogenesis|neuron projection development|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of programmed cell death|regulation of RNA metabolic process|cell cycle arrest|cell morphogenesis involved in differentiation|neuron migration|programmed cell death|intracellular signal transduction|gene expression|cell part morphogenesis|nervous system development|neuron projection guidance|extracellular matrix organization|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|RNA metabolic process|nucleus|regulation of programmed cell death|beta-amyloid binding|neuron development|neuron differentiation|axon guidance|positive regulation of apoptotic process|RNA biosynthetic process|regulation of RNA biosynthetic process|axon development|regulation of apoptotic process|negative regulation of apoptotic process|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription - - - - 4:40810027-41216714 103 135 223 619 704 618 0.238499506330156 0.284094936178999 0.46555168677605 1.28421334054417 1.33748546038523 1.3411155313172 0.329382043095068 1.32093811074887 -2.00372906331572 2.92753215713062e-14 1.23618875557252e-12 DOWN ENSG00000197386 HTT huntingtin [Source:HGNC Symbol;Acc:HGNC:4851] GO:0032502|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0051050|GO:0044089|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0042802|GO:0060341|GO:0007049|GO:1902117|GO:0051282|GO:0051640|GO:0043025|GO:1902115|GO:0044325|GO:0006810|GO:0022402|GO:0051130|GO:0010941|GO:0007275|GO:0010524|GO:0048513|GO:0005102|GO:0002039|GO:0043270|GO:0031982|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0030529|GO:0045502|GO:0012506|GO:0006928|GO:0042592|GO:0051656|GO:0043005|GO:0009966|GO:0019725|GO:0036477|GO:0014069|GO:0060548|GO:0032388|GO:0010646|GO:0032838|GO:0007163|GO:0007154|GO:0044092|GO:0055085|GO:0010970|GO:0060491|GO:0007165|GO:0005783|GO:0009968|GO:0051649|GO:0008134|GO:0045724|GO:0008092|GO:2000021|GO:0005522|GO:0006403|GO:0008219|GO:0050790|GO:0030030|GO:0051238|GO:0043086|GO:0048869|GO:0071598|GO:0009967|GO:0010469|GO:0007017|GO:0019538|GO:0031324|GO:0031323|GO:0010256|GO:0032411|GO:0005794|GO:0005768|GO:0006996|GO:0035770|GO:0016192|GO:1902533|GO:0051650|GO:0015631|GO:0032268|GO:0000902|GO:0005829|GO:0051653|GO:0005813|GO:0031344|GO:0007166|GO:1903047|GO:0030424|GO:0043412|GO:0007010|GO:0007030|GO:0007417|GO:0031410|GO:0043069|GO:2001234|GO:0048878|GO:0005815|GO:0032386|GO:0031346|GO:0005773|GO:1902017|GO:0051208|GO:0045505|GO:0034767|GO:0016023|GO:0005814|GO:0036211|GO:0044782|GO:0032269|GO:0000278|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0051279|GO:0005770|GO:0031981|GO:0030010|GO:0031585|GO:0030031|GO:0030425|GO:0007018|GO:0051346|GO:0006508|GO:0031988|GO:0034765|GO:0005654|GO:0022604|GO:0043269|GO:0051293|GO:0070925|GO:0012501|GO:0050658|GO:0006796|GO:0042384|GO:0035556|GO:0030659|GO:0033043|GO:0044267|GO:0051174|GO:0051281|GO:0032990|GO:0007399|GO:0032414|GO:0051648|GO:0051246|GO:0010522|GO:0048858|GO:1902531|GO:0051928|GO:0000226|GO:0072384|GO:0005856|GO:0005634|GO:0036464|GO:0043067|GO:0022898|GO:0097190|GO:0034452|GO:2000273|GO:0034220|GO:0010638|GO:0060271|GO:2001237|GO:0050850|GO:0010466|GO:0016311|GO:0098655|GO:0048487|GO:0051028|GO:0047496|GO:0051294|GO:0090280|GO:0030162|GO:0006812|GO:1901021|GO:2001236|GO:0052547|GO:0048193|GO:0060402|GO:0016482|GO:0032412|GO:0005776|GO:0030135|GO:0015630|GO:0031587|GO:2001259|GO:0040001|GO:0000132|GO:0042981|GO:0045861|GO:0050801|GO:0043066|GO:1904427|GO:0006464|GO:0030705|GO:0019932|GO:0097191|GO:0050848|GO:0006915|GO:0006873|GO:0090279|GO:0010921|GO:0006470|GO:0030136|GO:0035304|GO:1903169|GO:0043666|GO:0006890|GO:0010951|GO:1901019|GO:0030001|GO:0019722|GO:0051924|GO:2001257|GO:0030003|GO:0035303|GO:0052548|GO:0034047|GO:2000117|GO:0070588|GO:0055065|GO:0097553|GO:0006875|GO:2000116|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|macromolecular complex|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|positive regulation of transport|positive regulation of cellular component biogenesis|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|identical protein binding|regulation of cellular localization|cell cycle|positive regulation of organelle assembly|regulation of sequestering of calcium ion|organelle localization|neuronal cell body|regulation of organelle assembly|ion channel binding|transport|cell cycle process|positive regulation of cellular component organization|regulation of cell death|multicellular organism development|positive regulation of calcium ion transport into cytosol|animal organ development|receptor binding|p53 binding|positive regulation of ion transport|vesicle|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|dynein binding|vesicle membrane|movement of cell or subcellular component|homeostatic process|establishment of organelle localization|neuron projection|regulation of signal transduction|cellular homeostasis|somatodendritic compartment|postsynaptic density|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|cell projection cytoplasm|establishment or maintenance of cell polarity|cell communication|negative regulation of molecular function|transmembrane transport|establishment of localization by movement along microtubule|regulation of cell projection assembly|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|establishment of localization in cell|transcription factor binding|positive regulation of cilium assembly|cytoskeletal protein binding|regulation of ion homeostasis|profilin binding|RNA localization|cell death|regulation of catalytic activity|cell projection organization|sequestering of metal ion|negative regulation of catalytic activity|cellular developmental process|neuronal ribonucleoprotein granule|positive regulation of signal transduction|regulation of receptor activity|microtubule-based process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endomembrane system organization|positive regulation of transporter activity|Golgi apparatus|endosome|organelle organization|ribonucleoprotein granule|vesicle-mediated transport|positive regulation of intracellular signal transduction|establishment of vesicle localization|tubulin binding|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|spindle localization|centrosome|regulation of cell projection organization|cell surface receptor signaling pathway|mitotic cell cycle process|axon|macromolecule modification|cytoskeleton organization|Golgi organization|central nervous system development|cytoplasmic vesicle|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|chemical homeostasis|microtubule organizing center|regulation of intracellular transport|positive regulation of cell projection organization|vacuole|regulation of cilium assembly|sequestering of calcium ion|dynein intermediate chain binding|positive regulation of ion transmembrane transport|cytoplasmic, membrane-bounded vesicle|centriole|protein modification process|cilium organization|negative regulation of cellular protein metabolic process|mitotic cell cycle|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|regulation of release of sequestered calcium ion into cytosol|late endosome|nuclear lumen|establishment of cell polarity|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|cell projection assembly|dendrite|microtubule-based movement|negative regulation of hydrolase activity|proteolysis|membrane-bounded vesicle|regulation of ion transmembrane transport|nucleoplasm|regulation of cell morphogenesis|regulation of ion transport|establishment of spindle localization|organelle assembly|programmed cell death|RNA transport|phosphate-containing compound metabolic process|cilium assembly|intracellular signal transduction|cytoplasmic vesicle membrane|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of release of sequestered calcium ion into cytosol|cell part morphogenesis|nervous system development|positive regulation of ion transmembrane transporter activity|vesicle localization|regulation of protein metabolic process|regulation of calcium ion transport into cytosol|cell projection morphogenesis|regulation of intracellular signal transduction|positive regulation of calcium ion transport|microtubule cytoskeleton organization|organelle transport along microtubule|cytoskeleton|nucleus|cytoplasmic ribonucleoprotein granule|regulation of programmed cell death|regulation of transmembrane transporter activity|apoptotic signaling pathway|dynactin binding|positive regulation of receptor activity|ion transmembrane transport|positive regulation of organelle organization|cilium morphogenesis|negative regulation of extrinsic apoptotic signaling pathway|positive regulation of calcium-mediated signaling|negative regulation of peptidase activity|dephosphorylation|cation transmembrane transport|beta-tubulin binding|mRNA transport|vesicle transport along microtubule|establishment of spindle orientation|positive regulation of calcium ion import|regulation of proteolysis|cation transport|positive regulation of calcium ion transmembrane transporter activity|regulation of extrinsic apoptotic signaling pathway|regulation of peptidase activity|Golgi vesicle transport|calcium ion transport into cytosol|cytosolic transport|regulation of ion transmembrane transporter activity|autophagosome|coated vesicle|microtubule cytoskeleton|positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|positive regulation of cation channel activity|establishment of mitotic spindle localization|establishment of mitotic spindle orientation|regulation of apoptotic process|negative regulation of proteolysis|ion homeostasis|negative regulation of apoptotic process|positive regulation of calcium ion transmembrane transport|cellular protein modification process|cytoskeleton-dependent intracellular transport|second-messenger-mediated signaling|extrinsic apoptotic signaling pathway|regulation of calcium-mediated signaling|apoptotic process|cellular ion homeostasis|regulation of calcium ion import|regulation of phosphatase activity|protein dephosphorylation|clathrin-coated vesicle|regulation of protein dephosphorylation|regulation of calcium ion transmembrane transport|regulation of phosphoprotein phosphatase activity|retrograde vesicle-mediated transport, Golgi to ER|negative regulation of endopeptidase activity|regulation of calcium ion transmembrane transporter activity|metal ion transport|calcium-mediated signaling|regulation of calcium ion transport|regulation of cation channel activity|cellular cation homeostasis|regulation of dephosphorylation|regulation of endopeptidase activity|regulation of protein phosphatase type 2A activity|negative regulation of cysteine-type endopeptidase activity|calcium ion transmembrane transport|metal ion homeostasis|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|regulation of cysteine-type endopeptidase activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K04533 huntingtin[-] hsa05016 Huntington,s disease - Homo sapiens (human) 4:3074681-3243959 373 485 734 1745 2024 1867 1.03652896512356 1.22488202447482 1.83900564506857 4.34475886401579 4.61478030615245 4.86234532725547 1.36680554488898 4.60729483247457 -1.75311191695773 3.1315135159648e-14 1.32045486589849e-12 DOWN ENSG00000130675 MNX1 motor neuron and pancreas homeobox 1 [Source:HGNC Symbol;Acc:HGNC:4979] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0006955|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006959|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0021517|GO:0046483|GO:0043231|GO:0005737|GO:0031018|GO:0006139|GO:0031016|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0005730|GO:0000902|GO:0031175|GO:0003677|GO:0010468|GO:0034645|GO:0007417|GO:0051252|GO:0021510|GO:0035270|GO:0031981|GO:0001708|GO:0010467|GO:0032990|GO:0007399|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0021522|GO:0005634|GO:0045165|GO:0048666|GO:0030182|GO:0021953|GO:0021520|GO:0032774|GO:0043565|GO:2001141|GO:0021515|GO:0048663|GO:0048665|GO:0022008|GO:0048812|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:0048699|GO:1903506 developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|immune response|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|humoral immune response|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|ventral spinal cord development|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|endocrine pancreas development|nucleobase-containing compound metabolic process|pancreas development|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|nucleolus|cell morphogenesis|neuron projection development|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|central nervous system development|regulation of RNA metabolic process|spinal cord development|endocrine system development|nuclear lumen|cell fate specification|gene expression|cell part morphogenesis|nervous system development|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|spinal cord motor neuron differentiation|nucleus|cell fate commitment|neuron development|neuron differentiation|central nervous system neuron differentiation|spinal cord motor neuron cell fate specification|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|cell differentiation in spinal cord|neuron fate commitment|neuron fate specification|neurogenesis|neuron projection morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription K08025 homeobox protein HB9[-] hsa04950 Maturity onset diabetes of the young - Homo sapiens (human) 7:156994051-157010651 414 466 388 131 141 114 5.01285288265443 5.12802869191409 4.23574404162743 1.42119191364963 1.40078221278822 1.29364801280642 4.79220853873198 1.37187404641476 1.80454265827107 3.14732342134797e-14 1.32524955459693e-12 UP ENSG00000054392 HHAT hedgehog acyltransferase [Source:HGNC Symbol;Acc:HGNC:18270] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:1903829|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0060341|GO:0006810|GO:0051130|GO:0007275|GO:0043168|GO:0001882|GO:0051128|GO:0043231|GO:0016746|GO:0005737|GO:0032880|GO:0051222|GO:0045184|GO:0032388|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0051649|GO:0090316|GO:0000166|GO:0016021|GO:0044249|GO:0019538|GO:0006996|GO:0034645|GO:0007166|GO:0035639|GO:0043412|GO:0072594|GO:0007005|GO:0032386|GO:0001883|GO:0051223|GO:1903955|GO:0015031|GO:0036211|GO:0070201|GO:0046907|GO:0032549|GO:0042157|GO:0016747|GO:0034613|GO:0033043|GO:0044267|GO:0017076|GO:0006626|GO:0009059|GO:1903827|GO:0010638|GO:0032561|GO:0033365|GO:0033157|GO:0006839|GO:0007224|GO:0016409|GO:0006605|GO:0072655|GO:0010822|GO:0016482|GO:0006886|GO:0010821|GO:0042158|GO:0005525|GO:0006464|GO:1903214|GO:0019001|GO:1903533|GO:0006497|GO:0070585|GO:0018345 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|positive regulation of cellular protein localization|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of cellular localization|transport|positive regulation of cellular component organization|multicellular organism development|anion binding|nucleoside binding|regulation of cellular component organization|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|positive regulation of intracellular transport|protein localization|cell communication|signal transduction|endoplasmic reticulum|establishment of localization in cell|positive regulation of intracellular protein transport|nucleotide binding|integral component of membrane|cellular biosynthetic process|protein metabolic process|organelle organization|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|establishment of protein localization to organelle|mitochondrion organization|regulation of intracellular transport|purine nucleoside binding|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|protein modification process|regulation of establishment of protein localization|intracellular transport|ribonucleoside binding|lipoprotein metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein localization|regulation of organelle organization|cellular protein metabolic process|purine nucleotide binding|protein targeting to mitochondrion|macromolecule biosynthetic process|regulation of cellular protein localization|positive regulation of organelle organization|guanyl ribonucleotide binding|protein localization to organelle|regulation of intracellular protein transport|mitochondrial transport|smoothened signaling pathway|palmitoyltransferase activity|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|lipoprotein biosynthetic process|GTP binding|cellular protein modification process|regulation of protein targeting to mitochondrion|guanyl nucleotide binding|regulation of protein targeting|protein lipidation|protein localization to mitochondrion|protein palmitoylation - - - - 1:210328252-210676296 8 8 15 92 74 129 0.0808961406126262 0.0735237193184497 0.136760172376531 0.833573421757349 0.613984125529123 1.22257596926114 0.0970600107692023 0.890044505515871 -3.19692855268095 3.31846860071849e-14 1.39534593811056e-12 DOWN ENSG00000198753 PLXNB3 plexin B3 [Source:HGNC Symbol;Acc:HGNC:9105] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0038023|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0008360|GO:0006935|GO:0045595|GO:0048468|GO:0051130|GO:0007275|GO:0030155|GO:0051128|GO:0022607|GO:0005887|GO:0045597|GO:0004888|GO:0043235|GO:0006928|GO:0050673|GO:0019904|GO:0031226|GO:0007162|GO:0007154|GO:0044092|GO:0051270|GO:0060491|GO:0016477|GO:0007165|GO:0051271|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0016021|GO:2000145|GO:2000146|GO:0050679|GO:0000902|GO:0031175|GO:0031344|GO:0017154|GO:0007166|GO:0010720|GO:0031346|GO:0000904|GO:0030334|GO:0001935|GO:0051022|GO:0031345|GO:0060326|GO:0050769|GO:0030031|GO:0051346|GO:0022604|GO:0050678|GO:0002116|GO:0030336|GO:0097581|GO:0010591|GO:0050918|GO:0032990|GO:0007399|GO:0097485|GO:0010770|GO:0030154|GO:0048858|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0030032|GO:0010769|GO:1902285|GO:0043087|GO:0061564|GO:0001936|GO:0001938|GO:0071526|GO:0010593|GO:0050772|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0010976|GO:0034260|GO:0045666|GO:0007409|GO:0048699|GO:1902287|GO:0050770|GO:0045664 locomotion|developmental process|macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|signaling receptor activity|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|regulation of cell shape|chemotaxis|regulation of cell differentiation|cell development|positive regulation of cellular component organization|multicellular organism development|regulation of cell adhesion|regulation of cellular component organization|cellular component assembly|integral component of plasma membrane|positive regulation of cell differentiation|transmembrane signaling receptor activity|receptor complex|movement of cell or subcellular component|epithelial cell proliferation|protein domain specific binding|intrinsic component of plasma membrane|negative regulation of cell adhesion|cell communication|negative regulation of molecular function|regulation of cellular component movement|regulation of cell projection assembly|cell migration|signal transduction|negative regulation of cellular component movement|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|regulation of cell motility|negative regulation of cell motility|positive regulation of epithelial cell proliferation|cell morphogenesis|neuron projection development|regulation of cell projection organization|semaphorin receptor activity|cell surface receptor signaling pathway|positive regulation of cell development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|regulation of cell migration|endothelial cell proliferation|Rho GDP-dissociation inhibitor binding|negative regulation of cell projection organization|cell chemotaxis|positive regulation of neurogenesis|cell projection assembly|negative regulation of hydrolase activity|regulation of cell morphogenesis|regulation of epithelial cell proliferation|semaphorin receptor complex|negative regulation of cell migration|lamellipodium organization|regulation of lamellipodium assembly|positive chemotaxis|cell part morphogenesis|nervous system development|neuron projection guidance|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|cell projection morphogenesis|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|lamellipodium assembly|regulation of cell morphogenesis involved in differentiation|semaphorin-plexin signaling pathway involved in neuron projection guidance|regulation of GTPase activity|axon development|regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|semaphorin-plexin signaling pathway|negative regulation of lamellipodium assembly|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|negative regulation of GTPase activity|positive regulation of neuron differentiation|axonogenesis|generation of neurons|semaphorin-plexin signaling pathway involved in axon guidance|regulation of axonogenesis|regulation of neuron differentiation K06821 plexin B[-] hsa04360 Axon guidance - Homo sapiens (human) X:153764196-153779346 225 221 398 969 1023 1184 1.55838770823945 1.39112152982789 2.48536152072404 6.01331267346826 5.81347795005512 7.68551795479041 1.81162358626379 6.50410285943793 -1.8440668455053 3.50305712623788e-14 1.47088983750641e-12 DOWN ENSG00000131480 AOC2 amine oxidase, copper containing 2 [Source:HGNC Symbol;Acc:HGNC:549] GO:0009055|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0016491|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0048037|GO:0071944|GO:0005622|GO:0005886|GO:0048038|GO:0006725|GO:1901360|GO:0009410|GO:0050877|GO:0044281|GO:0043169|GO:0005737|GO:0006805|GO:0016638|GO:0055114|GO:0016641|GO:0046872|GO:0009308|GO:0007600|GO:0071466|GO:0018958|GO:0006584|GO:0052593|GO:0008131|GO:0050953|GO:0052596|GO:0046914|GO:0052595|GO:0052594|GO:0009712|GO:0005507|GO:0007601 electron carrier activity|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|oxidoreductase activity|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cofactor binding|cell periphery|intracellular|plasma membrane|quinone binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|response to xenobiotic stimulus|neurological system process|small molecule metabolic process|cation binding|cytoplasm|xenobiotic metabolic process|oxidoreductase activity, acting on the CH-NH2 group of donors|oxidation-reduction process|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|metal ion binding|amine metabolic process|sensory perception|cellular response to xenobiotic stimulus|phenol-containing compound metabolic process|catecholamine metabolic process|tryptamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|sensory perception of light stimulus|phenethylamine:oxygen oxidoreductase (deaminating) activity|transition metal ion binding|aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|catechol-containing compound metabolic process|copper ion binding|visual perception K00276 primary-amine oxidase[1.4.3.21] hsa01100|hsa00260|hsa00350|hsa00410|hsa00360 Metabolic pathways - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human)|Tyrosine metabolism - Homo sapiens (human)|beta-Alanine metabolism - Homo sapiens (human)|Phenylalanine metabolism - Homo sapiens (human) 17:42844600-42850707 203 212 224 29 28 60 2.81616180004725 2.67285899995347 2.8017029137363 0.360465319963166 0.318704239296856 0.780082043521455 2.76357457124567 0.486417200927159 2.50626939011556 3.62634836759504e-14 1.52051972143515e-12 UP ENSG00000129245 FXR2 fragile X mental retardation, autosomal homolog 2 [Source:HGNC Symbol;Acc:HGNC:4024] GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0006914|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0005622|GO:0002682|GO:0005515|GO:0019222|GO:0042802|GO:0050688|GO:0003676|GO:0034641|GO:0006952|GO:0031982|GO:0098542|GO:0043231|GO:0005737|GO:0030529|GO:0009615|GO:0009890|GO:0070062|GO:0016236|GO:0051607|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0098792|GO:0003723|GO:0010629|GO:0005840|GO:0032269|GO:0005844|GO:0015934|GO:0043603|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0005634|GO:0050691|GO:0043043|GO:0017148|GO:0022626|GO:0010608|GO:0006412|GO:0002230|GO:0006417|GO:0022625|GO:0044822|GO:0003729 macromolecular complex|immune system process|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|autophagy|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|intracellular|regulation of immune system process|protein binding|regulation of metabolic process|identical protein binding|regulation of defense response to virus|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|vesicle|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|response to virus|negative regulation of biosynthetic process|extracellular exosome|macroautophagy|defense response to virus|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|xenophagy|RNA binding|negative regulation of gene expression|ribosome|negative regulation of cellular protein metabolic process|polysome|large ribosomal subunit|cellular amide metabolic process|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|regulation of defense response to virus by host|peptide biosynthetic process|negative regulation of translation|cytosolic ribosome|posttranscriptional regulation of gene expression|translation|positive regulation of defense response to virus by host|regulation of translation|cytosolic large ribosomal subunit|poly(A) RNA binding|mRNA binding K15516 fragile X mental retardation protein[-] hsa03013 RNA transport - Homo sapiens (human) 17:7591230-7614871 3422 3501 3190 1309 1411 1088 41.5484924081589 38.6320148301996 34.9204793596929 14.2400870099764 14.0562781224459 12.3803496592875 38.3669955326838 13.5589049305699 1.50062512830824 3.81084088295564e-14 1.59563595679884e-12 UP ENSG00000271430 RP3-368A4.5 - - - - - - - X:74200229-74242148 51 48 57 204 284 257 0.92573193808793 0.791837439003165 0.93283265108598 3.31774316251218 4.22962941477707 4.37196614436377 0.883467342725692 3.97311290721767 -2.1690210804505 3.83240988932746e-14 1.60241967557398e-12 DOWN ENSG00000133216 EPHB2 EPH receptor B2 [Source:HGNC Symbol;Acc:HGNC:3393] GO:0040011|GO:0032502|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0004872|GO:0048523|GO:0050794|GO:0044089|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0044708|GO:0071944|GO:0009605|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0048646|GO:0042802|GO:0048514|GO:0050804|GO:0006935|GO:0045595|GO:0048468|GO:0043025|GO:0051130|GO:0048839|GO:0001568|GO:0007275|GO:0045596|GO:0048513|GO:0050877|GO:0005102|GO:0016358|GO:0043168|GO:0030900|GO:0001882|GO:0016772|GO:0051128|GO:0007420|GO:0022607|GO:0050803|GO:0005887|GO:0045597|GO:0004888|GO:0005737|GO:0007267|GO:0060322|GO:0007423|GO:0006928|GO:0051963|GO:0009887|GO:0022038|GO:0043005|GO:0048598|GO:0048568|GO:0036477|GO:0008037|GO:0010646|GO:0031226|GO:0001525|GO:0007154|GO:0060996|GO:0007165|GO:0051965|GO:0050808|GO:0021675|GO:0007611|GO:0021602|GO:0000166|GO:0030030|GO:0048869|GO:0016021|GO:0021537|GO:0019538|GO:0050878|GO:0060021|GO:0050768|GO:0008046|GO:0000902|GO:0005829|GO:0031175|GO:0031344|GO:0048167|GO:0007416|GO:0007166|GO:0001654|GO:0021631|GO:0035639|GO:0060997|GO:0030424|GO:0001944|GO:0043412|GO:0050807|GO:0072358|GO:0007417|GO:0007612|GO:0001655|GO:0043583|GO:0010720|GO:0097061|GO:0048813|GO:0001883|GO:0010721|GO:0000904|GO:0009790|GO:0036211|GO:0032549|GO:0031345|GO:0042472|GO:0050769|GO:0030425|GO:0008038|GO:0022604|GO:0016301|GO:0006796|GO:0044267|GO:0032990|GO:0048562|GO:0007399|GO:0050890|GO:0097485|GO:0017076|GO:0030154|GO:0048858|GO:0072359|GO:0016773|GO:0051960|GO:0021545|GO:0048666|GO:0030182|GO:0007411|GO:0021953|GO:0010975|GO:0048168|GO:0010769|GO:0043010|GO:0007413|GO:0005524|GO:0021554|GO:0048170|GO:0030554|GO:0016310|GO:0061564|GO:0042471|GO:0007167|GO:0021954|GO:0004672|GO:0045665|GO:0022008|GO:0048667|GO:0004714|GO:0006464|GO:0050767|GO:0048812|GO:0010977|GO:0050771|GO:0048592|GO:0048169|GO:0021955|GO:0007409|GO:0048593|GO:0006468|GO:0048699|GO:0004713|GO:0018193|GO:0071679|GO:0005003|GO:0031290|GO:0050770|GO:0045664|GO:0007268|GO:0007169|GO:0021952|GO:0005005|GO:0048013|GO:0018108 locomotion|developmental process|signal transducer activity|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|receptor activity|negative regulation of cellular process|regulation of cellular process|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|single-organism behavior|cell periphery|response to external stimulus|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|identical protein binding|blood vessel morphogenesis|modulation of synaptic transmission|chemotaxis|regulation of cell differentiation|cell development|neuronal cell body|positive regulation of cellular component organization|inner ear development|blood vessel development|multicellular organism development|negative regulation of cell differentiation|animal organ development|neurological system process|receptor binding|dendrite development|anion binding|forebrain development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|brain development|cellular component assembly|regulation of synapse structure or activity|integral component of plasma membrane|positive regulation of cell differentiation|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|head development|sensory organ development|movement of cell or subcellular component|regulation of synapse assembly|organ morphogenesis|corpus callosum development|neuron projection|embryonic morphogenesis|embryonic organ development|somatodendritic compartment|cell recognition|regulation of cell communication|intrinsic component of plasma membrane|angiogenesis|cell communication|dendritic spine development|signal transduction|positive regulation of synapse assembly|synapse organization|nerve development|learning or memory|cranial nerve morphogenesis|nucleotide binding|cell projection organization|cellular developmental process|integral component of membrane|telencephalon development|protein metabolic process|regulation of body fluid levels|palate development|negative regulation of neurogenesis|axon guidance receptor activity|cell morphogenesis|cytosol|neuron projection development|regulation of cell projection organization|regulation of synaptic plasticity|synapse assembly|cell surface receptor signaling pathway|eye development|optic nerve morphogenesis|purine ribonucleoside triphosphate binding|dendritic spine morphogenesis|axon|vasculature development|macromolecule modification|regulation of synapse organization|cardiovascular system development|central nervous system development|learning|urogenital system development|ear development|positive regulation of cell development|dendritic spine organization|dendrite morphogenesis|purine nucleoside binding|negative regulation of cell development|cell morphogenesis involved in differentiation|embryo development|protein modification process|ribonucleoside binding|negative regulation of cell projection organization|inner ear morphogenesis|positive regulation of neurogenesis|dendrite|neuron recognition|regulation of cell morphogenesis|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|cognition|neuron projection guidance|purine nucleotide binding|cell differentiation|cell projection morphogenesis|circulatory system development|phosphotransferase activity, alcohol group as acceptor|regulation of nervous system development|cranial nerve development|neuron development|neuron differentiation|axon guidance|central nervous system neuron differentiation|regulation of neuron projection development|regulation of neuronal synaptic plasticity|regulation of cell morphogenesis involved in differentiation|camera-type eye development|axonal fasciculation|ATP binding|optic nerve development|positive regulation of long-term neuronal synaptic plasticity|adenyl nucleotide binding|phosphorylation|axon development|ear morphogenesis|enzyme linked receptor protein signaling pathway|central nervous system neuron development|protein kinase activity|negative regulation of neuron differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|negative regulation of neuron projection development|negative regulation of axonogenesis|eye morphogenesis|regulation of long-term neuronal synaptic plasticity|central nervous system neuron axonogenesis|axonogenesis|camera-type eye morphogenesis|protein phosphorylation|generation of neurons|protein tyrosine kinase activity|peptidyl-amino acid modification|commissural neuron axon guidance|ephrin receptor activity|retinal ganglion cell axon guidance|regulation of axonogenesis|regulation of neuron differentiation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|central nervous system projection neuron axonogenesis|transmembrane-ephrin receptor activity|ephrin receptor signaling pathway|peptidyl-tyrosine phosphorylation K05111 Eph receptor B2[2.7.10.1] hsa04360 Axon guidance - Homo sapiens (human) 1:22710839-22921500 146 177 296 710 941 795 0.71121575766644 0.783615652685984 1.30003692256394 3.09888206829857 3.76102884713234 3.62948806210479 0.931622777638788 3.49646632584523 -1.90807979263477 4.29690138302066e-14 1.79412159284893e-12 DOWN ENSG00000175198 PCCA propionyl-CoA carboxylase alpha subunit [Source:HGNC Symbol;Acc:HGNC:8653] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0031640|GO:0019835|GO:0033218|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0044255|GO:1901360|GO:0009374|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0043177|GO:0051186|GO:0019842|GO:0006629|GO:0000166|GO:0006790|GO:0055114|GO:0051701|GO:0005829|GO:0006768|GO:0046872|GO:0035639|GO:0004075|GO:0016042|GO:0044242|GO:0006631|GO:0001883|GO:0034440|GO:0032549|GO:0005759|GO:0005739|GO:0043603|GO:0031406|GO:0017076|GO:0030258|GO:0006766|GO:0019836|GO:0005524|GO:0046395|GO:0030554|GO:0004658|GO:0046459|GO:0019752|GO:0009062|GO:0006767|GO:0019395|GO:0006635|GO:0019626|GO:0032787 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|killing of cells of other organism|cytolysis|amide binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|ligase activity|intracellular|protein binding|cellular lipid metabolic process|organic cyclic compound metabolic process|biotin binding|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|organic acid binding|cofactor metabolic process|vitamin binding|lipid metabolic process|nucleotide binding|sulfur compound metabolic process|oxidation-reduction process|interaction with host|cytosol|biotin metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|biotin carboxylase activity|lipid catabolic process|cellular lipid catabolic process|fatty acid metabolic process|purine nucleoside binding|lipid oxidation|ribonucleoside binding|mitochondrial matrix|mitochondrion|cellular amide metabolic process|carboxylic acid binding|purine nucleotide binding|lipid modification|vitamin metabolic process|hemolysis by symbiont of host erythrocytes|ATP binding|carboxylic acid catabolic process|adenyl nucleotide binding|propionyl-CoA carboxylase activity|short-chain fatty acid metabolic process|carboxylic acid metabolic process|fatty acid catabolic process|water-soluble vitamin metabolic process|fatty acid oxidation|fatty acid beta-oxidation|short-chain fatty acid catabolic process|monocarboxylic acid metabolic process K01965 propionyl-CoA carboxylase alpha chain[6.4.1.3] hsa01100|hsa01200|hsa00280|hsa00640|hsa00630 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Valine, leucine and isoleucine degradation - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human)|Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) 13:100089015-100530435 15 20 41 160 162 233 0.153929577063242 0.186529238587174 0.379341362155034 1.47114693544659 1.36401775340777 2.24090427129255 0.239933392601817 1.69202298671564 -2.81804330507101 4.51436806023337e-14 1.88228972165094e-12 DOWN ENSG00000124574 ABCC10 ATP binding cassette subfamily C member 10 [Source:HGNC Symbol;Acc:HGNC:52] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0043167|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005886|GO:0031090|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005774|GO:0005737|GO:0055085|GO:0000166|GO:0016021|GO:0016820|GO:0035639|GO:0001883|GO:0005773|GO:0016818|GO:0032549|GO:0017076|GO:0000323|GO:0005524|GO:0030554|GO:0042626|GO:0016462|GO:0005765|GO:0005764|GO:0017111|GO:0016887|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|ion binding|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|plasma membrane|organelle membrane|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|transmembrane transport|nucleotide binding|integral component of membrane|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|purine ribonucleoside triphosphate binding|purine nucleoside binding|vacuole|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|purine nucleotide binding|lytic vacuole|ATP binding|adenyl nucleotide binding|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|lysosomal membrane|lysosome|nucleoside-triphosphatase activity|ATPase activity|ATPase activity, coupled|ATPase activity, coupled to movement of substances K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10[-] - - 6:43427366-43450430 80 76 151 433 476 493 0.436075370243415 0.376499572937449 0.742101582204335 2.1147398832307 2.12885732092321 2.51852989463962 0.518225508461733 2.25404236626451 -2.12086269647084 4.56392312127384e-14 1.90029791997921e-12 DOWN ENSG00000133812 SBF2 SET binding factor 2 [Source:HGNC Symbol;Acc:HGNC:2135] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0008289|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0005085|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0007275|GO:0019208|GO:0043168|GO:0005543|GO:0022607|GO:0043231|GO:0019899|GO:0005774|GO:0005737|GO:0005088|GO:0046983|GO:0043085|GO:0050790|GO:0051345|GO:0035091|GO:0005773|GO:0017112|GO:0019902|GO:0006461|GO:0007399|GO:0042803|GO:0008366|GO:0051259|GO:0043087|GO:0043547|GO:0042552|GO:0051262 developmental process|cell|membrane|cellular process|metabolic process|binding|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|lipid binding|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|guanyl-nucleotide exchange factor activity|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|multicellular organism development|phosphatase regulator activity|anion binding|phospholipid binding|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|vacuolar membrane|cytoplasm|Ras guanyl-nucleotide exchange factor activity|protein dimerization activity|positive regulation of catalytic activity|regulation of catalytic activity|positive regulation of hydrolase activity|phosphatidylinositol binding|vacuole|Rab guanyl-nucleotide exchange factor activity|phosphatase binding|protein complex assembly|nervous system development|protein homodimerization activity|axon ensheathment|protein oligomerization|regulation of GTPase activity|positive regulation of GTPase activity|myelination|protein tetramerization - - - - 11:9778667-10294207 64 71 196 661 648 959 0.221495514043214 0.223319578857664 0.611583954674258 2.04967468630299 1.84004871169372 3.11052391066232 0.352133015858379 2.33341576955301 -2.7282509853788 4.59239367674941e-14 1.90948914798993e-12 DOWN ENSG00000113621 TXNDC15 thioredoxin domain containing 15 [Source:HGNC Symbol;Acc:HGNC:20652] GO:0005623|GO:0016020|GO:0009987|GO:0050794|GO:0031224|GO:0042592|GO:0019725|GO:0016021|GO:0045454 cell|membrane|cellular process|regulation of cellular process|intrinsic component of membrane|homeostatic process|cellular homeostasis|integral component of membrane|cell redox homeostasis - - - - 5:134873803-134901525 43 36 23 253 283 178 0.264128938793274 0.200967599413555 0.12737598313195 1.3923941216331 1.42625934367852 1.02469117132618 0.19749084044626 1.28111487887927 -2.69754220113768 4.91807531798912e-14 2.04206148182541e-12 DOWN ENSG00000168564 CDKN2AIP CDKN2A interacting protein [Source:HGNC Symbol;Acc:HGNC:24325] GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0016049|GO:0023051|GO:0045926|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0005622|GO:0005515|GO:0003676|GO:0002039|GO:0030307|GO:0051128|GO:0033554|GO:0043231|GO:0030308|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0031647|GO:0009967|GO:0001558|GO:0005730|GO:0003723|GO:0031981|GO:0005654|GO:0005634|GO:0006974|GO:0001652 growth|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|cell growth|regulation of signaling|negative regulation of growth|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|intracellular|protein binding|nucleic acid binding|p53 binding|positive regulation of cell growth|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|negative regulation of cell growth|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|regulation of protein stability|positive regulation of signal transduction|regulation of cell growth|nucleolus|RNA binding|nuclear lumen|nucleoplasm|nucleus|cellular response to DNA damage stimulus|granular component - - - - 4:183444591-183448198 1124 1124 931 361 319 408 15.1415416809895 13.7610072815665 11.3075219620315 4.35720554435665 3.5258329562475 5.15101293432266 13.4033569748625 4.34468381164227 1.62527128760395 5.26774145340216e-14 2.18421046319261e-12 UP ENSG00000182247 UBE2E2 ubiquitin conjugating enzyme E2E 2 [Source:HGNC Symbol;Acc:HGNC:12478] GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016874|GO:0005515|GO:0016740|GO:0051726|GO:0007049|GO:0022402|GO:0043168|GO:0001882|GO:0033554|GO:0045787|GO:0019787|GO:0000166|GO:0019538|GO:0042296|GO:0090068|GO:0035639|GO:1903047|GO:0043412|GO:0004842|GO:0001883|GO:0044770|GO:0036211|GO:0000278|GO:0032549|GO:0007346|GO:0010564|GO:0044267|GO:0017076|GO:0045931|GO:0006974|GO:0061631|GO:0005524|GO:0044772|GO:0030554|GO:1901990|GO:1901989|GO:1901992|GO:1901987|GO:0006464|GO:1900087|GO:2000045|GO:0032020|GO:1902808|GO:1902806|GO:0000082|GO:0032446|GO:0016567|GO:0000209|GO:0070534|GO:0070936|GO:0070979 cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|ligase activity|protein binding|transferase activity|regulation of cell cycle|cell cycle|cell cycle process|anion binding|nucleoside binding|cellular response to stress|positive regulation of cell cycle|ubiquitin-like protein transferase activity|nucleotide binding|protein metabolic process|ISG15 transferase activity|positive regulation of cell cycle process|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|ubiquitin-protein transferase activity|purine nucleoside binding|cell cycle phase transition|protein modification process|mitotic cell cycle|ribonucleoside binding|regulation of mitotic cell cycle|regulation of cell cycle process|cellular protein metabolic process|purine nucleotide binding|positive regulation of mitotic cell cycle|cellular response to DNA damage stimulus|ubiquitin conjugating enzyme activity|ATP binding|mitotic cell cycle phase transition|adenyl nucleotide binding|regulation of mitotic cell cycle phase transition|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|regulation of cell cycle phase transition|cellular protein modification process|positive regulation of G1/S transition of mitotic cell cycle|regulation of G1/S transition of mitotic cell cycle|ISG15-protein conjugation|positive regulation of cell cycle G1/S phase transition|regulation of cell cycle G1/S phase transition|G1/S transition of mitotic cell cycle|protein modification by small protein conjugation|protein ubiquitination|protein polyubiquitination|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination K06689 ubiquitin-conjugating enzyme E2 D/E[2.3.2.23] hsa04141|hsa04120 Protein processing in endoplasmic reticulum - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human) 3:23203020-23591793 29 34 82 266 331 331 0.368554207136208 0.392700012700029 0.939573619659187 3.02887706243436 3.45142238187625 3.94238804766266 0.566942613165141 3.47422916399109 -2.61541830316539 5.3722093172513e-14 2.22443740578669e-12 DOWN ENSG00000172915 NBEA neurobeachin [Source:HGNC Symbol;Acc:HGNC:7648] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0043231|GO:0019899|GO:0005737|GO:0008104|GO:0005794|GO:0005829|GO:0005802|GO:0019900|GO:0019901 cell|membrane|binding|intracellular organelle|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein localization|Golgi apparatus|cytosol|trans-Golgi network|kinase binding|protein kinase binding - - - - 13:34942287-35673022 71 56 178 638 640 1230 0.326760890217362 0.23422829644944 0.738596373584909 2.63081571117161 2.41668341975797 5.30524995077433 0.43319518675057 3.45091636056797 -2.99389038947195 5.40019135907062e-14 2.23292677054978e-12 DOWN ENSG00000137834 SMAD6 SMAD family member 6 [Source:HGNC Symbol;Acc:HGNC:6772] GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0005057|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0016043|GO:0007155|GO:0043227|GO:0023057|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042802|GO:0007507|GO:0042127|GO:0006725|GO:0001822|GO:0009888|GO:0035295|GO:1901360|GO:0001568|GO:0010941|GO:0034405|GO:0007275|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0005072|GO:0046483|GO:0051128|GO:0090287|GO:0022607|GO:0043231|GO:0046332|GO:0043169|GO:0019899|GO:0005737|GO:0007389|GO:0003170|GO:0071559|GO:0005667|GO:0031589|GO:0009966|GO:0003682|GO:0060548|GO:0010646|GO:0090288|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0003279|GO:0009725|GO:0008219|GO:0008285|GO:0048869|GO:0044249|GO:0019538|GO:0043254|GO:0010033|GO:0031324|GO:0031323|GO:0003205|GO:0032268|GO:0005829|GO:0003677|GO:0031333|GO:0010468|GO:0005126|GO:0071773|GO:0034645|GO:0046872|GO:0070410|GO:0090101|GO:0007166|GO:0033993|GO:0001944|GO:0043412|GO:0030514|GO:0072164|GO:0072358|GO:0001655|GO:0060976|GO:0043069|GO:0009798|GO:0051252|GO:0009880|GO:0009790|GO:0036211|GO:0032269|GO:0060840|GO:0071560|GO:0072001|GO:0003002|GO:0033612|GO:0003231|GO:0070848|GO:0030617|GO:0006461|GO:0034616|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0072073|GO:0044267|GO:0070411|GO:0051174|GO:0010467|GO:0071310|GO:0030510|GO:0051246|GO:0009059|GO:0030154|GO:0003281|GO:0070412|GO:0001823|GO:0016070|GO:0072359|GO:0005634|GO:0043067|GO:0048545|GO:0044389|GO:0031625|GO:0000975|GO:0045444|GO:0000578|GO:0060393|GO:0034622|GO:0001657|GO:0032774|GO:0043565|GO:0010991|GO:2001141|GO:0043623|GO:0071363|GO:0072163|GO:0016310|GO:0043627|GO:0007179|GO:0003690|GO:0030512|GO:0030509|GO:0007167|GO:0009953|GO:0060394|GO:0042981|GO:0035904|GO:0043066|GO:0005160|GO:0009950|GO:0006464|GO:0017015|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:0007183|GO:0006357|GO:0006468|GO:1903506|GO:0044212|GO:0034713|GO:0042325|GO:0001932|GO:0042326|GO:0007352|GO:0007178|GO:0001933|GO:0000976|GO:0001012|GO:0060389|GO:0070698|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|receptor signaling protein activity|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cellular component organization|cell adhesion|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|identical protein binding|heart development|regulation of cell proliferation|cellular aromatic compound metabolic process|kidney development|tissue development|tube development|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to fluid shear stress|multicellular organism development|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|transforming growth factor beta receptor, cytoplasmic mediator activity|heterocycle metabolic process|regulation of cellular component organization|regulation of cellular response to growth factor stimulus|cellular component assembly|intracellular membrane-bounded organelle|SMAD binding|cation binding|enzyme binding|cytoplasm|pattern specification process|heart valve development|response to transforming growth factor beta|transcription factor complex|cell-substrate adhesion|regulation of signal transduction|chromatin binding|negative regulation of cell death|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|cardiac septum development|response to hormone|cell death|negative regulation of cell proliferation|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of protein complex assembly|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cardiac chamber development|regulation of cellular protein metabolic process|cytosol|DNA binding|negative regulation of protein complex assembly|regulation of gene expression|cytokine receptor binding|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|metal ion binding|co-SMAD binding|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|response to lipid|vasculature development|macromolecule modification|negative regulation of BMP signaling pathway|mesonephric tubule development|cardiovascular system development|urogenital system development|coronary vasculature development|negative regulation of programmed cell death|axis specification|regulation of RNA metabolic process|embryonic pattern specification|embryo development|protein modification process|negative regulation of cellular protein metabolic process|artery development|cellular response to transforming growth factor beta stimulus|renal system development|regionalization|receptor serine/threonine kinase binding|cardiac ventricle development|response to growth factor|transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity|protein complex assembly|response to laminar fluid shear stress|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|kidney epithelium development|cellular protein metabolic process|I-SMAD binding|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|regulation of BMP signaling pathway|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|ventricular septum development|R-SMAD binding|mesonephros development|RNA metabolic process|circulatory system development|nucleus|regulation of programmed cell death|response to steroid hormone|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|regulatory region DNA binding|fat cell differentiation|embryonic axis specification|regulation of pathway-restricted SMAD protein phosphorylation|cellular macromolecular complex assembly|ureteric bud development|RNA biosynthetic process|sequence-specific DNA binding|negative regulation of SMAD protein complex assembly|regulation of RNA biosynthetic process|cellular protein complex assembly|cellular response to growth factor stimulus|mesonephric epithelium development|phosphorylation|response to estrogen|transforming growth factor beta receptor signaling pathway|double-stranded DNA binding|negative regulation of transforming growth factor beta receptor signaling pathway|BMP signaling pathway|enzyme linked receptor protein signaling pathway|dorsal/ventral pattern formation|negative regulation of pathway-restricted SMAD protein phosphorylation|regulation of apoptotic process|aorta development|negative regulation of apoptotic process|transforming growth factor beta receptor binding|dorsal/ventral axis specification|cellular protein modification process|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|SMAD protein complex assembly|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|type I transforming growth factor beta receptor binding|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|zygotic specification of dorsal/ventral axis|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|pathway-restricted SMAD protein phosphorylation|type I activin receptor binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K04677 mothers against decapentaplegic homolog 6[-] hsa04350 TGF-beta signaling pathway - Homo sapiens (human) 15:66702228-66782848 55 73 96 292 338 339 0.352688932510318 0.42543771883147 0.555032136250297 1.67768722500909 1.7783415108845 2.03732103644842 0.444386262530695 1.83111659078067 -2.04283752929122 5.65818766264788e-14 2.33636977151715e-12 DOWN ENSG00000011105 TSPAN9 tetraspanin 9 [Source:HGNC Symbol;Acc:HGNC:21640] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0051716|GO:0030055|GO:0050794|GO:0071944|GO:0031224|GO:0005886|GO:0005924|GO:0005912|GO:0005887|GO:0031226|GO:0007154|GO:0007165|GO:0016021|GO:0097197|GO:0007166|GO:0005925 signaling|cell|membrane|cellular process|cell junction|response to stimulus|cellular response to stimulus|cell-substrate junction|regulation of cellular process|cell periphery|intrinsic component of membrane|plasma membrane|cell-substrate adherens junction|adherens junction|integral component of plasma membrane|intrinsic component of plasma membrane|cell communication|signal transduction|integral component of membrane|tetraspanin-enriched microdomain|cell surface receptor signaling pathway|focal adhesion - - - - 12:3077355-3286564 28 33 70 239 250 319 0.203118246692392 0.217568597402027 0.457833057436414 1.55343481555155 1.48800428575565 2.1687860129225 0.292839967176944 1.73674170474323 -2.56819883350051 5.90430410263007e-14 2.43127027144715e-12 DOWN ENSG00000107929 LARP4B La ribonucleoprotein domain family member 4B [Source:HGNC Symbol;Acc:HGNC:28987] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003676|GO:0034641|GO:0031325|GO:0043231|GO:0005737|GO:0030529|GO:0000166|GO:0044249|GO:0019538|GO:0031323|GO:0035770|GO:0005730|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0005840|GO:0010628|GO:0031981|GO:0005844|GO:0051247|GO:0032270|GO:0043603|GO:0044267|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0010557|GO:0005634|GO:0036464|GO:0043043|GO:0045727|GO:0010608|GO:0006412|GO:0006417|GO:0042788|GO:0044822|GO:0010494 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleotide binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|ribonucleoprotein granule|nucleolus|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|ribosome|positive regulation of gene expression|nuclear lumen|polysome|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of macromolecule biosynthetic process|nucleus|cytoplasmic ribonucleoprotein granule|peptide biosynthetic process|positive regulation of translation|posttranscriptional regulation of gene expression|translation|regulation of translation|polysomal ribosome|poly(A) RNA binding|cytoplasmic stress granule - - - - 10:806914-931705 202 249 418 1279 1050 1020 0.645007101747769 0.722591461307551 1.20338366140427 3.65916063107162 2.75087166489881 3.0524047440672 0.856994074819863 3.15414568001254 -1.8798921603672 5.90038782359133e-14 2.43127027144715e-12 DOWN ENSG00000113569 NUP155 nucleoporin 155kDa [Source:HGNC Symbol;Acc:HGNC:8063] GO:0005215|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0017056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0016032|GO:0007049|GO:0042391|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0071166|GO:0034641|GO:0044281|GO:0046483|GO:0033554|GO:0043231|GO:0003012|GO:0007267|GO:0009408|GO:0005975|GO:0005635|GO:0006928|GO:0045184|GO:0016458|GO:0006139|GO:0008104|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0051649|GO:0006403|GO:0031965|GO:0030029|GO:0044249|GO:0009266|GO:0019538|GO:0010033|GO:0010256|GO:0003013|GO:0006996|GO:0051701|GO:1900034|GO:0019048|GO:0006998|GO:0010468|GO:0006936|GO:0019054|GO:0086019|GO:0007166|GO:1903047|GO:0043412|GO:0072594|GO:0034097|GO:0061337|GO:0031047|GO:0010629|GO:0030048|GO:0015031|GO:0001508|GO:0036211|GO:0000278|GO:0046907|GO:0019083|GO:0034605|GO:0034613|GO:0050658|GO:0044267|GO:0010467|GO:0017038|GO:0019058|GO:0071310|GO:0006997|GO:0009059|GO:0016070|GO:0008643|GO:0008015|GO:0005634|GO:0006606|GO:0005643|GO:0086065|GO:0010827|GO:0006941|GO:0008016|GO:0070252|GO:0007077|GO:0086001|GO:0019221|GO:0033365|GO:0051028|GO:0051169|GO:0006396|GO:0032774|GO:0060047|GO:0034660|GO:0006605|GO:0006886|GO:0051081|GO:0086066|GO:0071345|GO:0006406|GO:0006464|GO:0006405|GO:0086003|GO:0006913|GO:0008645|GO:0086002|GO:0060048|GO:0006399|GO:0018193|GO:0043687|GO:0034504|GO:0086014|GO:0008033|GO:0032446|GO:0051170|GO:0051168|GO:0015758|GO:0018205|GO:0016925 transporter activity|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|structural constituent of nuclear pore|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|viral process|cell cycle|regulation of membrane potential|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|ribonucleoprotein complex localization|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|muscle system process|cell-cell signaling|response to heat|carbohydrate metabolic process|nuclear envelope|movement of cell or subcellular component|establishment of protein localization|gene silencing|nucleobase-containing compound metabolic process|protein localization|cell communication|transmembrane transport|membrane organization|signal transduction|establishment of localization in cell|RNA localization|nuclear membrane|actin filament-based process|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|response to organic substance|endomembrane system organization|circulatory system process|organelle organization|interaction with host|regulation of cellular response to heat|modulation by virus of host morphology or physiology|nuclear envelope organization|regulation of gene expression|muscle contraction|modulation by virus of host process|cell-cell signaling involved in cardiac conduction|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|establishment of protein localization to organelle|response to cytokine|cardiac conduction|gene silencing by RNA|negative regulation of gene expression|actin filament-based movement|protein transport|action potential|protein modification process|mitotic cell cycle|intracellular transport|viral transcription|cellular response to heat|cellular protein localization|RNA transport|cellular protein metabolic process|gene expression|protein import|viral life cycle|cellular response to organic substance|nucleus organization|macromolecule biosynthetic process|RNA metabolic process|carbohydrate transport|blood circulation|nucleus|protein import into nucleus|nuclear pore|cell communication involved in cardiac conduction|regulation of glucose transport|striated muscle contraction|regulation of heart contraction|actin-mediated cell contraction|mitotic nuclear envelope disassembly|cardiac muscle cell action potential|cytokine-mediated signaling pathway|protein localization to organelle|mRNA transport|nuclear transport|RNA processing|RNA biosynthetic process|heart contraction|ncRNA metabolic process|protein targeting|intracellular protein transport|nuclear envelope disassembly|atrial cardiac muscle cell to AV node cell communication|cellular response to cytokine stimulus|mRNA export from nucleus|cellular protein modification process|RNA export from nucleus|cardiac muscle cell contraction|nucleocytoplasmic transport|hexose transport|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|tRNA metabolic process|peptidyl-amino acid modification|post-translational protein modification|protein localization to nucleus|atrial cardiac muscle cell action potential|tRNA processing|protein modification by small protein conjugation|nuclear import|nuclear export|glucose transport|peptidyl-lysine modification|protein sumoylation K14312 nuclear pore complex protein Nup155[-] hsa03013 RNA transport - Homo sapiens (human) 5:37288137-37371181 381 445 615 1671 1834 1343 2.34823676141897 2.49262698003344 3.41748430587226 9.22765933129322 9.27437356475527 7.75751225978821 2.75278268244156 8.75318171861223 -1.66891680022575 5.97073738216773e-14 2.4552395841217e-12 DOWN ENSG00000169155 ZBTB43 zinc finger and BTB domain containing 43 [Source:HGNC Symbol;Acc:HGNC:17908] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 9:126805006-126838210 711 925 1266 280 354 369 3.96327151456511 4.6860398500483 6.36256458856371 1.39842881528805 1.6190299447182 1.92770234683969 5.00395865105904 1.64838703561531 1.60201484607292 6.29512250324332e-14 2.58506997540339e-12 UP ENSG00000149328 GLB1L2 galactosidase beta 1 like 2 [Source:HGNC Symbol;Acc:HGNC:25129] GO:0005576|GO:0008152|GO:0003824|GO:0071704|GO:0016787|GO:0016798|GO:0005975|GO:0004553|GO:0004565 extracellular region|metabolic process|catalytic activity|organic substance metabolic process|hydrolase activity|hydrolase activity, acting on glycosyl bonds|carbohydrate metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|beta-galactosidase activity - - - - 11:134331874-134378341 184 210 344 860 893 910 1.33973977673726 1.38963802744257 2.25826548138814 5.6104656524682 5.33485182845985 6.20973480041343 1.66254776185599 5.71835076044716 -1.78220332968071 6.4731515693287e-14 2.65452564492773e-12 DOWN ENSG00000164308 ERAP2 endoplasmic reticulum aminopeptidase 2 [Source:HGNC Symbol;Acc:HGNC:29499] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0033218|GO:0019882|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005886|GO:0012505|GO:0031090|GO:0002250|GO:0042277|GO:0034641|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0005783|GO:0019883|GO:0008217|GO:0048002|GO:0016021|GO:0019538|GO:0003013|GO:0006518|GO:0046872|GO:0043171|GO:0006508|GO:0002474|GO:0043603|GO:0005788|GO:0008015|GO:0008237|GO:0008238|GO:0046914|GO:0019885|GO:0008235|GO:0004177|GO:0008270|GO:0070006 immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|amide binding|antigen processing and presentation|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|plasma membrane|endomembrane system|organelle membrane|adaptive immune response|peptide binding|cellular nitrogen compound metabolic process|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|endoplasmic reticulum|antigen processing and presentation of endogenous antigen|regulation of blood pressure|antigen processing and presentation of peptide antigen|integral component of membrane|protein metabolic process|circulatory system process|peptide metabolic process|metal ion binding|peptide catabolic process|proteolysis|antigen processing and presentation of peptide antigen via MHC class I|cellular amide metabolic process|endoplasmic reticulum lumen|blood circulation|metallopeptidase activity|exopeptidase activity|transition metal ion binding|antigen processing and presentation of endogenous peptide antigen via MHC class I|metalloexopeptidase activity|aminopeptidase activity|zinc ion binding|metalloaminopeptidase activity - - - - 5:96875939-96919716 204 267 347 891 915 911 1.4193281647403 1.68827973637941 2.17669092965996 5.5542882055114 5.22326107080298 5.94019178205415 1.76143294359322 5.57258035278951 -1.66159596072874 6.65264422650343e-14 2.7243901335807e-12 DOWN ENSG00000185085 INTS5 integrator complex subunit 5 [Source:HGNC Symbol;Acc:HGNC:29352] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0032039|GO:0016021|GO:0031981|GO:1990234|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0034660|GO:0016591|GO:0016073|GO:0016180 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|integrator complex|integral component of membrane|nuclear lumen|transferase complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|ncRNA metabolic process|DNA-directed RNA polymerase II, holoenzyme|snRNA metabolic process|snRNA processing - - - - 11:62646848-62653302 1318 1440 1164 405 503 501 28.380865426898 28.1807722047158 22.5983917266107 7.8138142191493 8.88681617723311 10.1105993675831 26.3866764527415 8.9370765879885 1.56193475379379 6.84445835079048e-14 2.799102186363e-12 UP ENSG00000178764 ZHX2 zinc fingers and homeoboxes 2 [Source:HGNC Symbol;Acc:HGNC:18513] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0000989|GO:0043227|GO:0071944|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0042802|GO:0045595|GO:0003712|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0046983|GO:0009890|GO:0006139|GO:0048869|GO:0044249|GO:0019827|GO:0031324|GO:0031323|GO:0050768|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0046872|GO:0010629|GO:0046982|GO:0051252|GO:0010721|GO:0044265|GO:0031981|GO:0005654|GO:0035019|GO:0010467|GO:0007399|GO:0019439|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0042803|GO:0051960|GO:0030182|GO:0006401|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0016071|GO:0045665|GO:0022008|GO:0050767|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:1903506|GO:0006402|GO:0000122|GO:0045664 developmental process|cell|membrane|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|cell periphery|biosynthetic process|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein dimerization activity|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|stem cell population maintenance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of neurogenesis|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|metal ion binding|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|negative regulation of cell development|cellular macromolecule catabolic process|nuclear lumen|nucleoplasm|somatic stem cell population maintenance|gene expression|nervous system development|aromatic compound catabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|protein homodimerization activity|regulation of nervous system development|neuron differentiation|RNA catabolic process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|mRNA metabolic process|negative regulation of neuron differentiation|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|mRNA catabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of neuron differentiation - - - - 8:122781394-122974512 25 22 61 227 230 250 0.321709744429229 0.257289548069771 0.707724404087487 2.61724079591798 2.42837699306106 3.01501761814473 0.428907898862162 2.68687846904126 -2.64719127756023 6.96765747005697e-14 2.8455874980996e-12 DOWN ENSG00000145431 PDGFC platelet derived growth factor C [Source:HGNC Symbol;Acc:HGNC:8801] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0009986|GO:0044237|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0008284|GO:0051272|GO:0042127|GO:0048565|GO:0006725|GO:0035295|GO:1901360|GO:0007275|GO:0048513|GO:0051302|GO:0005102|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:2000147|GO:0022607|GO:0043231|GO:0010243|GO:0048144|GO:0005737|GO:0006928|GO:0009887|GO:0009966|GO:0046983|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0070062|GO:0060348|GO:0050790|GO:0051781|GO:0051301|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0005794|GO:0000165|GO:1902533|GO:0032268|GO:0034645|GO:0055123|GO:0007166|GO:0070851|GO:0043412|GO:0007417|GO:0009790|GO:0071417|GO:0030334|GO:0043200|GO:0051347|GO:0036211|GO:0048145|GO:0051247|GO:0048146|GO:0006259|GO:0006461|GO:0032270|GO:0051054|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0005788|GO:0007399|GO:0071310|GO:0000139|GO:0031328|GO:0051246|GO:0009059|GO:0001501|GO:0030335|GO:1902531|GO:0008083|GO:0010557|GO:0005634|GO:0042803|GO:0031401|GO:0006260|GO:0034622|GO:0043408|GO:0014068|GO:0043623|GO:0016310|GO:0070371|GO:0048017|GO:0007167|GO:0043410|GO:0006275|GO:0014066|GO:0045740|GO:0006464|GO:0043549|GO:0071230|GO:0005161|GO:0033674|GO:0045859|GO:0048015|GO:0045860|GO:0043406|GO:0006468|GO:0043405|GO:0042325|GO:0070374|GO:0001932|GO:0018193|GO:0001934|GO:0007171|GO:0070372|GO:0042327|GO:0007169|GO:0050730|GO:0048008|GO:0046777|GO:0031952|GO:0071902|GO:0014065|GO:0071900|GO:0031954|GO:0032147|GO:0018108 locomotion|developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cell surface|cellular metabolic process|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|extracellular space|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|digestive tract development|cellular aromatic compound metabolic process|tube development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell motility|cellular component assembly|intracellular membrane-bounded organelle|response to organonitrogen compound|fibroblast proliferation|cytoplasm|movement of cell or subcellular component|organ morphogenesis|regulation of signal transduction|protein dimerization activity|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|extracellular exosome|bone development|regulation of catalytic activity|positive regulation of cell division|cell division|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cellular macromolecule biosynthetic process|digestive system development|cell surface receptor signaling pathway|growth factor receptor binding|macromolecule modification|central nervous system development|embryo development|cellular response to organonitrogen compound|regulation of cell migration|response to amino acid|positive regulation of transferase activity|protein modification process|regulation of fibroblast proliferation|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|DNA metabolic process|protein complex assembly|positive regulation of cellular protein metabolic process|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|endoplasmic reticulum lumen|nervous system development|cellular response to organic substance|Golgi membrane|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|skeletal system development|positive regulation of cell migration|regulation of intracellular signal transduction|growth factor activity|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|positive regulation of protein modification process|DNA replication|cellular macromolecular complex assembly|regulation of MAPK cascade|positive regulation of phosphatidylinositol 3-kinase signaling|cellular protein complex assembly|phosphorylation|ERK1 and ERK2 cascade|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|regulation of DNA replication|regulation of phosphatidylinositol 3-kinase signaling|positive regulation of DNA replication|cellular protein modification process|regulation of kinase activity|cellular response to amino acid stimulus|platelet-derived growth factor receptor binding|positive regulation of kinase activity|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|activation of transmembrane receptor protein tyrosine kinase activity|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of peptidyl-tyrosine phosphorylation|platelet-derived growth factor receptor signaling pathway|protein autophosphorylation|regulation of protein autophosphorylation|positive regulation of protein serine/threonine kinase activity|phosphatidylinositol 3-kinase signaling|regulation of protein serine/threonine kinase activity|positive regulation of protein autophosphorylation|activation of protein kinase activity|peptidyl-tyrosine phosphorylation K05450 platelet derived growth factor C/D[-] hsa04151|hsa04060|hsa04014|hsa04810|hsa04015|hsa04510|hsa04072|hsa05231|hsa05215|hsa04540|hsa05218 PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Melanoma - Homo sapiens (human) 4:156760454-156971394 17 22 48 171 187 207 0.127316432037401 0.14974278938481 0.324116437002489 1.14746142356829 1.14908583684598 1.45292130176784 0.200391886141567 1.2498228540607 -2.64082762617302 7.0523297904985e-14 2.87623297220686e-12 DOWN ENSG00000117595 IRF6 interferon regulatory factor 6 [Source:HGNC Symbol;Acc:HGNC:6121] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:1903561|GO:0051716|GO:0097159|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0051726|GO:0042127|GO:0007049|GO:0045087|GO:0006725|GO:0009888|GO:0048468|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0006952|GO:0031982|GO:0031325|GO:0046483|GO:0045786|GO:0043231|GO:0005737|GO:0050673|GO:0006139|GO:0007154|GO:0007165|GO:0070062|GO:0008285|GO:0048869|GO:0044249|GO:0010033|GO:0031323|GO:0048732|GO:0005829|GO:0003677|GO:0030879|GO:0034340|GO:0010468|GO:0034645|GO:0007166|GO:0034097|GO:0051252|GO:0007050|GO:0010628|GO:0034341|GO:0043588|GO:0060429|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0043616|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0019221|GO:0071346|GO:0030855|GO:0032774|GO:0030216|GO:2001141|GO:0071357|GO:0008544|GO:0071345|GO:0061180|GO:0006351|GO:0006355|GO:0060644|GO:0060333|GO:1903506|GO:0060337|GO:0009913 developmental process|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|innate immune response|cellular aromatic compound metabolic process|tissue development|cell development|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|defense response|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|epithelial cell proliferation|nucleobase-containing compound metabolic process|cell communication|signal transduction|extracellular exosome|negative regulation of cell proliferation|cellular developmental process|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|gland development|cytosol|DNA binding|mammary gland development|response to type I interferon|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|response to cytokine|regulation of RNA metabolic process|cell cycle arrest|positive regulation of gene expression|response to interferon-gamma|skin development|epithelium development|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|keratinocyte proliferation|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|cellular response to interferon-gamma|epithelial cell differentiation|RNA biosynthetic process|keratinocyte differentiation|regulation of RNA biosynthetic process|cellular response to type I interferon|epidermis development|cellular response to cytokine stimulus|mammary gland epithelium development|transcription, DNA-templated|regulation of transcription, DNA-templated|mammary gland epithelial cell differentiation|interferon-gamma-mediated signaling pathway|regulation of nucleic acid-templated transcription|type I interferon signaling pathway|epidermal cell differentiation - - - - 1:209785623-209806175 2324 2467 2992 851 989 1143 19.3175582021926 18.6365437369764 22.4229133015265 6.33787052871599 6.74497912882244 8.90412770012174 20.1256717468985 7.32899245255339 1.45735015400627 7.2048279466735e-14 2.93441928403807e-12 UP ENSG00000281344 HELLPAR HELLP associated long non-coding RNA [Source:HGNC Symbol;Acc:HGNC:43984] - - - - - - 12:102197585-102402596 15 17 30 111 131 150 0.00517548521402125 0.00533097847931853 0.0093325015684334 0.0343153094726967 0.0370857706768868 0.0485051173012553 0.00661298842059106 0.0399687324836129 -2.59549754121423 7.37293102667591e-14 2.99879404455562e-12 DOWN ENSG00000135473 PAN2 PAN2 poly(A) specific ribonuclease subunit [Source:HGNC Symbol;Acc:HGNC:20074] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0044089|GO:0071704|GO:0009056|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:1902117|GO:0006725|GO:1902115|GO:0051130|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0030529|GO:0006139|GO:0022613|GO:0031251|GO:0006996|GO:0035770|GO:0005829|GO:0010603|GO:0044265|GO:0022618|GO:0004518|GO:0010606|GO:0070925|GO:0033043|GO:0010467|GO:0019439|GO:0016070|GO:0005634|GO:0036464|GO:0010638|GO:0006401|GO:0090501|GO:0034622|GO:0006396|GO:0004527|GO:0016071|GO:0004540|GO:0090305|GO:0033962|GO:0000932|GO:0004532|GO:0008408|GO:0006402|GO:0006397|GO:0090503|GO:0000956|GO:0000175|GO:0016896|GO:0000289|GO:0004535|GO:0000288 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|positive regulation of organelle assembly|cellular aromatic compound metabolic process|regulation of organelle assembly|positive regulation of cellular component organization|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|PAN complex|organelle organization|ribonucleoprotein granule|cytosol|regulation of cytoplasmic mRNA processing body assembly|cellular macromolecule catabolic process|ribonucleoprotein complex assembly|nuclease activity|positive regulation of cytoplasmic mRNA processing body assembly|organelle assembly|regulation of organelle organization|gene expression|aromatic compound catabolic process|RNA metabolic process|nucleus|cytoplasmic ribonucleoprotein granule|positive regulation of organelle organization|RNA catabolic process|RNA phosphodiester bond hydrolysis|cellular macromolecular complex assembly|RNA processing|exonuclease activity|mRNA metabolic process|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|cytoplasmic mRNA processing body assembly|cytoplasmic mRNA processing body|exoribonuclease activity|3'-5' exonuclease activity|mRNA catabolic process|mRNA processing|RNA phosphodiester bond hydrolysis, exonucleolytic|nuclear-transcribed mRNA catabolic process|3'-5'-exoribonuclease activity|exoribonuclease activity, producing 5'-phosphomonoesters|nuclear-transcribed mRNA poly(A) tail shortening|poly(A)-specific ribonuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K12571 PAB-dependent poly(A)-specific ribonuclease subunit 2[3.1.13.4] hsa03018 RNA degradation - Homo sapiens (human) 12:56316223-56334053 43 44 58 195 251 316 0.172159206426497 0.160099688220458 0.209364968726265 0.699504725489839 0.824518509055223 1.18569756956779 0.180541287791073 0.903240268037617 -2.32278100221746 7.39449053122961e-14 3.00347102475277e-12 DOWN ENSG00000140350 ANP32A acidic nuclear phosphoprotein 32 family member A [Source:HGNC Symbol;Acc:HGNC:13233] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0005783|GO:0051649|GO:0044249|GO:0043487|GO:0031323|GO:0010468|GO:0034645|GO:0003723|GO:0051252|GO:0046907|GO:0031981|GO:0048471|GO:0005654|GO:0035556|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0043488|GO:0051169|GO:0032774|GO:2001141|GO:0010608|GO:0044822|GO:0006351|GO:0006355|GO:0006913|GO:1903506 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|endoplasmic reticulum|establishment of localization in cell|cellular biosynthetic process|regulation of RNA stability|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|regulation of RNA metabolic process|intracellular transport|nuclear lumen|perinuclear region of cytoplasm|nucleoplasm|intracellular signal transduction|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulation of mRNA stability|nuclear transport|RNA biosynthetic process|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|regulation of nucleic acid-templated transcription - - - - 15:68778535-68820897 908 926 977 3040 3705 2501 5.41195289009389 5.01601808009219 5.25021245922839 16.2345227490193 18.1185910352022 13.9704627259051 5.22606114313816 16.1078588367089 -1.62396882529762 8.23528331212504e-14 3.34043679348072e-12 DOWN ENSG00000149600 COMMD7 COMM domain containing 7 [Source:HGNC Symbol;Acc:HGNC:16223] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0009890|GO:0006139|GO:0007154|GO:0044092|GO:0007165|GO:0070062|GO:0008134|GO:0016021|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0051090|GO:0010468|GO:0034645|GO:0007166|GO:0034097|GO:0031410|GO:0010629|GO:0051252|GO:0016023|GO:0031988|GO:0043433|GO:0051059|GO:0010467|GO:0071310|GO:0009059|GO:0016070|GO:0019221|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0071345|GO:0032088|GO:0034612|GO:0006351|GO:0006355|GO:1903507|GO:0071356|GO:1903506|GO:0033209 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|negative regulation of molecular function|signal transduction|extracellular exosome|transcription factor binding|integral component of membrane|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|response to cytokine|cytoplasmic vesicle|negative regulation of gene expression|regulation of RNA metabolic process|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|negative regulation of sequence-specific DNA binding transcription factor activity|NF-kappaB binding|gene expression|cellular response to organic substance|macromolecule biosynthetic process|RNA metabolic process|cytokine-mediated signaling pathway|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|cellular response to cytokine stimulus|negative regulation of NF-kappaB transcription factor activity|response to tumor necrosis factor|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|tumor necrosis factor-mediated signaling pathway - - - - 20:32702691-32743997 144 151 197 593 600 539 2.16725465769746 2.0654070294888 2.67318635654484 7.996509636323 7.40912406834846 7.60266592140761 2.30194934791037 7.66943320869302 -1.73626387394562 9.03902930853896e-14 3.66148142438429e-12 DOWN ENSG00000271533 RP3-368A4.6 - - - - - - - X:74209976-74213660 22 23 32 111 185 179 0.42230790931032 0.401258717089951 0.55382114397316 1.90910453883758 2.91371706789431 3.22025217757666 0.459129256791144 2.68102459476952 -2.54581218215651 9.61106025694575e-14 3.88792131315526e-12 DOWN ENSG00000131791 PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9379] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0042802|GO:0051726|GO:0007049|GO:0044255|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0006082|GO:0034641|GO:0015980|GO:0044281|GO:0016772|GO:0046483|GO:0045786|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0031588|GO:0006139|GO:0007154|GO:0055085|GO:0061024|GO:0006629|GO:0007165|GO:0042180|GO:0051649|GO:0009725|GO:0016236|GO:0050790|GO:0006091|GO:0005952|GO:0044249|GO:0010876|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0055114|GO:0032268|GO:0005829|GO:0034645|GO:0007166|GO:0043412|GO:0007005|GO:0015697|GO:0006631|GO:1901652|GO:0007050|GO:1903825|GO:0071417|GO:0036211|GO:0046907|GO:0006811|GO:0031981|GO:0043434|GO:1990234|GO:0006869|GO:0005654|GO:0016301|GO:0010565|GO:0019900|GO:0006112|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0008610|GO:0019216|GO:0071310|GO:0046890|GO:0051246|GO:0009059|GO:0016070|GO:0016773|GO:0032870|GO:0005634|GO:0034220|GO:0019217|GO:0098655|GO:0006820|GO:0015711|GO:0098656|GO:1901653|GO:0032774|GO:0006839|GO:0015879|GO:0006812|GO:0015696|GO:0016310|GO:0015908|GO:0046942|GO:0007167|GO:0006633|GO:0071375|GO:0004672|GO:0019752|GO:0032868|GO:0019901|GO:0006464|GO:0042304|GO:0043549|GO:0006853|GO:0006351|GO:0015718|GO:0006366|GO:0045859|GO:1902603|GO:0006352|GO:1902911|GO:0072488|GO:0006468|GO:0042325|GO:0001932|GO:0032869|GO:0004674|GO:0032787|GO:0015672|GO:0007169|GO:0015909|GO:0006367|GO:1902554|GO:0004679|GO:0008286 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|identical protein binding|regulation of cell cycle|cell cycle|cellular lipid metabolic process|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|nucleotide-activated protein kinase complex|nucleobase-containing compound metabolic process|cell communication|transmembrane transport|membrane organization|lipid metabolic process|signal transduction|cellular ketone metabolic process|establishment of localization in cell|response to hormone|macroautophagy|regulation of catalytic activity|generation of precursor metabolites and energy|cAMP-dependent protein kinase complex|cellular biosynthetic process|lipid localization|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|regulation of cellular protein metabolic process|cytosol|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|macromolecule modification|mitochondrion organization|quaternary ammonium group transport|fatty acid metabolic process|response to peptide|cell cycle arrest|organic acid transmembrane transport|cellular response to organonitrogen compound|protein modification process|intracellular transport|ion transport|nuclear lumen|response to peptide hormone|transferase complex|lipid transport|nucleoplasm|kinase activity|regulation of cellular ketone metabolic process|kinase binding|energy reserve metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|cellular response to organic substance|regulation of lipid biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|nucleus|ion transmembrane transport|regulation of fatty acid metabolic process|cation transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|cellular response to peptide|RNA biosynthetic process|mitochondrial transport|carnitine transport|cation transport|ammonium transport|phosphorylation|fatty acid transport|carboxylic acid transport|enzyme linked receptor protein signaling pathway|fatty acid biosynthetic process|cellular response to peptide hormone stimulus|protein kinase activity|carboxylic acid metabolic process|response to insulin|protein kinase binding|cellular protein modification process|regulation of fatty acid biosynthetic process|regulation of kinase activity|carnitine shuttle|transcription, DNA-templated|monocarboxylic acid transport|transcription from RNA polymerase II promoter|regulation of protein kinase activity|carnitine transmembrane transport|DNA-templated transcription, initiation|protein kinase complex|ammonium transmembrane transport|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|protein serine/threonine kinase activity|monocarboxylic acid metabolic process|monovalent inorganic cation transport|transmembrane receptor protein tyrosine kinase signaling pathway|long-chain fatty acid transport|transcription initiation from RNA polymerase II promoter|serine/threonine protein kinase complex|AMP-activated protein kinase activity|insulin receptor signaling pathway K07199 5'-AMP-activated protein kinase, regulatory beta subunit[-] hsa04921|hsa04932|hsa04910|hsa04068|hsa04152|hsa04931|hsa04922|hsa04211|hsa05410|hsa04920|hsa04213|hsa04710 Oxytocin signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Circadian rhythm - Homo sapiens (human) 1:147155106-147172550 83 78 259 887 861 1088 0.957310272129095 0.817611211832287 2.69331185436972 9.16630112098598 8.14786824224249 11.7606256505803 1.48941111277703 9.69159833793626 -2.70199258753696 9.74826501285841e-14 3.93808800668302e-12 DOWN ENSG00000254615 RP11-395G23.3 - - - - - - - 8:106270144-106272899 267 248 396 93 66 55 9.67559212600932 8.16764903463588 12.9382382721113 3.019567048511 1.96236968381001 1.86789912719104 10.2604931442522 2.28327861983735 2.16792125001744 1.01939217784322e-13 4.11255865909886e-12 UP ENSG00000141219 C17orf80 chromosome 17 open reading frame 80 [Source:HGNC Symbol;Acc:HGNC:29601] GO:0016020|GO:0005576|GO:1903561|GO:0043227|GO:0031224|GO:0031982|GO:0070062|GO:0016021 membrane|extracellular region|extracellular vesicle|membrane-bounded organelle|intrinsic component of membrane|vesicle|extracellular exosome|integral component of membrane - - - - 17:73232233-73248947 50 62 63 356 317 214 0.415167351720395 0.467873310118829 0.471641877363816 2.64852847863465 2.1596526023519 1.66532602765486 0.451560846401013 2.15783570288047 -2.25659271800782 1.02213735414294e-13 4.1180686330072e-12 DOWN ENSG00000146416 AIG1 androgen-induced 1 [Source:HGNC Symbol;Acc:HGNC:21607] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 6:143060496-143340304 61 57 119 383 377 379 0.419500219051061 0.356251861089328 0.737839910239604 2.35991299540804 2.12719842693221 2.44268624848563 0.504530663459998 2.30993255694196 -2.19483687127471 1.04351371582229e-13 4.19852540056047e-12 DOWN ENSG00000131374 TBC1D5 TBC1 domain family member 5 [Source:HGNC Symbol;Acc:HGNC:19166] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0071944|GO:0030904|GO:0009605|GO:0009893|GO:0030234|GO:0005905|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0030119|GO:0010506|GO:0006810|GO:0031623|GO:0051130|GO:0009991|GO:0098797|GO:0060627|GO:0008047|GO:0031982|GO:0031325|GO:0051128|GO:0033554|GO:0030117|GO:0045807|GO:0043231|GO:0005737|GO:0010508|GO:0012506|GO:0032403|GO:0030666|GO:0045184|GO:0043085|GO:0008104|GO:0030132|GO:0000422|GO:0051649|GO:0016236|GO:0010008|GO:0050790|GO:0031323|GO:0042594|GO:0005768|GO:0006996|GO:0016192|GO:0035612|GO:0005096|GO:1903008|GO:0000423|GO:0031410|GO:0051345|GO:0002090|GO:1990316|GO:0030131|GO:0007005|GO:0030695|GO:0048260|GO:0015031|GO:0005773|GO:0016023|GO:0030665|GO:0046907|GO:1990234|GO:0030100|GO:0031988|GO:0002092|GO:0030118|GO:0030669|GO:0030659|GO:0030122|GO:0030120|GO:0031667|GO:0043112|GO:0030139|GO:0048259|GO:0042147|GO:0030125|GO:0043087|GO:0016482|GO:0043547|GO:0005776|GO:0030135|GO:0016197|GO:0030128|GO:0006897|GO:0098779|GO:0030136|GO:1902911|GO:0006898|GO:0045334|GO:1902554 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|cell periphery|retromer complex|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|coated pit|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|AP-type membrane coat adaptor complex|regulation of autophagy|transport|receptor internalization|positive regulation of cellular component organization|response to extracellular stimulus|plasma membrane protein complex|regulation of vesicle-mediated transport|enzyme activator activity|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|membrane coat|positive regulation of endocytosis|intracellular membrane-bounded organelle|cytoplasm|positive regulation of autophagy|vesicle membrane|protein complex binding|endocytic vesicle membrane|establishment of protein localization|positive regulation of catalytic activity|protein localization|clathrin coat of coated pit|mitophagy|establishment of localization in cell|macroautophagy|endosome membrane|regulation of catalytic activity|regulation of cellular metabolic process|response to starvation|endosome|organelle organization|vesicle-mediated transport|AP-2 adaptor complex binding|GTPase activator activity|organelle disassembly|macromitophagy|cytoplasmic vesicle|positive regulation of hydrolase activity|regulation of receptor internalization|ATG1/ULK1 kinase complex|clathrin adaptor complex|mitochondrion organization|GTPase regulator activity|positive regulation of receptor-mediated endocytosis|protein transport|vacuole|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|intracellular transport|transferase complex|regulation of endocytosis|membrane-bounded vesicle|positive regulation of receptor internalization|clathrin coat|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle membrane|AP-2 adaptor complex|vesicle coat|response to nutrient levels|receptor metabolic process|endocytic vesicle|regulation of receptor-mediated endocytosis|retrograde transport, endosome to Golgi|clathrin vesicle coat|regulation of GTPase activity|cytosolic transport|positive regulation of GTPase activity|autophagosome|coated vesicle|endosomal transport|clathrin coat of endocytic vesicle|endocytosis|mitophagy in response to mitochondrial depolarization|clathrin-coated vesicle|protein kinase complex|receptor-mediated endocytosis|clathrin-coated endocytic vesicle|serine/threonine protein kinase complex - - - - 3:17157162-18444817 59 77 134 390 458 403 0.25960723229124 0.307921913706533 0.531603553278079 1.53755281039493 1.65349019208096 1.66188978547149 0.366377566425284 1.61764426264913 -2.14249130456363 1.05045155629443e-13 4.2207511119265e-12 DOWN ENSG00000125775 SDCBP2 syndecan binding protein 2 [Source:HGNC Symbol;Acc:HGNC:15756] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0051641|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0042802|GO:0008022|GO:0006810|GO:0007275|GO:0031982|GO:0005737|GO:0046983|GO:0007154|GO:0007165|GO:0070062|GO:0051649|GO:0046982|GO:0046907|GO:0035556|GO:0007399|GO:0042803 developmental process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|cellular localization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|identical protein binding|protein C-terminus binding|transport|multicellular organism development|vesicle|cytoplasm|protein dimerization activity|cell communication|signal transduction|extracellular exosome|establishment of localization in cell|protein heterodimerization activity|intracellular transport|intracellular signal transduction|nervous system development|protein homodimerization activity - - - - 20:1309909-1329239 31 25 56 200 201 229 0.562555116166358 0.412317336232583 0.916240165074966 3.25185266646553 2.99272760058944 3.89464844632075 0.630370872491302 3.37974290445857 -2.42264072658578 1.07661910186443e-13 4.32007885309954e-12 DOWN ENSG00000139973 SYT16 synaptotagmin 16 [Source:HGNC Symbol;Acc:HGNC:23142] GO:0005623|GO:0009987|GO:0005488|GO:0043167|GO:0008289|GO:0005515|GO:0042802|GO:0006810|GO:0043168|GO:0032940|GO:0005543|GO:0030276|GO:0043169|GO:0046983|GO:0000149|GO:0016192|GO:0046872|GO:0046982|GO:0006887|GO:0046903|GO:0019905|GO:0042803|GO:0005509 cell|cellular process|binding|ion binding|lipid binding|protein binding|identical protein binding|transport|anion binding|secretion by cell|phospholipid binding|clathrin binding|cation binding|protein dimerization activity|SNARE binding|vesicle-mediated transport|metal ion binding|protein heterodimerization activity|exocytosis|secretion|syntaxin binding|protein homodimerization activity|calcium ion binding - - - - 14:61995823-62112550 19 32 76 281 348 306 0.0768246728300895 0.117594241827496 0.277066334459972 1.01802963641855 1.15452640888388 1.15959624377479 0.157161749705853 1.11071742969241 -2.82116979700345 1.08805619731348e-13 4.36011137108678e-12 DOWN ENSG00000038532 CLEC16A C-type lectin domain family 16 member A [Source:HGNC Symbol;Acc:HGNC:29013] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0006914|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0005774|GO:0005737|GO:0010008|GO:0005768|GO:0005773|GO:0000323|GO:0005765|GO:0005764 cell|membrane|cellular process|binding|intracellular organelle|autophagy|membrane-bounded organelle|intracellular|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|endosome membrane|endosome|vacuole|lytic vacuole|lysosomal membrane|lysosome - - - - 16:10944488-11182189 95 96 207 539 646 725 0.365176972847827 0.33537555698243 0.717405154188356 1.85638286525232 2.03742143044991 2.61184815994893 0.472652561339538 2.16855081855039 -2.19787927391611 1.1415891187903e-13 4.56849886760931e-12 DOWN ENSG00000158966 CACHD1 cache domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29314] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 1:64470792-64693058 7 4 13 66 83 64 0.0593584357602019 0.0308258461179906 0.0993863943635107 0.501439467229322 0.577458106082433 0.508613262787961 0.0631902254139011 0.529170278699905 -3.06595871634242 1.19512187475149e-13 4.77632777092786e-12 DOWN ENSG00000105732 ZNF574 zinc finger protein 574 [Source:HGNC Symbol;Acc:HGNC:26166] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:42068477-42081565 1438 1358 1081 431 479 442 7.38436065675739 6.33773342446518 5.00488605278209 1.98302851248429 2.01816732440477 2.12718448841904 6.24232671133489 2.04279344176937 1.61154053459842 1.2371592888843e-13 4.93772104416468e-12 UP ENSG00000115993 TRAK2 trafficking protein, kinesin binding 2 [Source:HGNC Symbol;Acc:HGNC:13206] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0071944|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0019222|GO:0006486|GO:0006725|GO:0006810|GO:1901360|GO:0005102|GO:0034641|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0005975|GO:0045184|GO:0006139|GO:0008104|GO:0051649|GO:0044249|GO:0019538|GO:0031323|GO:0005768|GO:0010468|GO:0034645|GO:0043412|GO:0005769|GO:0051252|GO:0015031|GO:0006493|GO:0009100|GO:0036211|GO:0046907|GO:0050811|GO:0070085|GO:0005739|GO:0034613|GO:1901137|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0009101|GO:0043413|GO:0032774|GO:2001141|GO:0006605|GO:0006886|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 cell|membrane|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|cell periphery|biosynthetic process|intracellular|protein binding|plasma membrane|endomembrane system|regulation of metabolic process|protein glycosylation|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|carbohydrate metabolic process|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|establishment of localization in cell|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|endosome|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|early endosome|regulation of RNA metabolic process|protein transport|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|intracellular transport|GABA receptor binding|glycosylation|mitochondrion|cellular protein localization|carbohydrate derivative biosynthetic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|glycoprotein biosynthetic process|macromolecule glycosylation|RNA biosynthetic process|regulation of RNA biosynthetic process|protein targeting|intracellular protein transport|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription K15374 trafficking kinesin-binding protein 2[-] hsa01100|hsa04727 Metabolic pathways - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human) 2:201377207-201451611 210 194 317 1007 816 799 1.49503933460182 1.25520698503819 2.03473650063458 6.42334647896327 4.76641857830184 5.3310123924451 1.59499427342486 5.50692581657007 -1.78769592994048 1.33080505897515e-13 5.30438641263606e-12 DOWN ENSG00000126226 PCID2 PCI domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25653] GO:0032502|GO:0002376|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0016043|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:1903706|GO:0045595|GO:0006725|GO:0050867|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0051302|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0045786|GO:0045597|GO:0002696|GO:0001775|GO:0051782|GO:0045787|GO:0060548|GO:0006139|GO:0046649|GO:0050865|GO:0044092|GO:0051983|GO:0008219|GO:0050790|GO:0007059|GO:0051301|GO:0043086|GO:0048869|GO:0044249|GO:0019538|GO:0043487|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0051249|GO:0032268|GO:0000819|GO:0042113|GO:0010468|GO:0000075|GO:0034645|GO:0090068|GO:1903047|GO:0043412|GO:0030097|GO:0030163|GO:0030098|GO:0051304|GO:0043069|GO:0051252|GO:0048536|GO:0044770|GO:0044265|GO:0010628|GO:0036211|GO:0032269|GO:0000278|GO:0051251|GO:0007346|GO:0010564|GO:0045930|GO:0051346|GO:0006508|GO:0012501|GO:0033043|GO:0044267|GO:0042176|GO:0007067|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0016070|GO:0045931|GO:0042177|GO:0010557|GO:0043067|GO:0043488|GO:0010948|GO:0090267|GO:0002521|GO:0044257|GO:0031577|GO:0010466|GO:0045893|GO:2001251|GO:0010498|GO:0030183|GO:0007093|GO:0007088|GO:1901978|GO:0032774|GO:1903363|GO:0044772|GO:0030162|GO:2001141|GO:0007094|GO:0045619|GO:0071174|GO:0033044|GO:0010608|GO:0052547|GO:0050871|GO:0090266|GO:1901990|GO:0051603|GO:0045839|GO:0050864|GO:0000070|GO:0042981|GO:0051306|GO:0045861|GO:0043066|GO:1901987|GO:0051438|GO:0007091|GO:0006464|GO:0045621|GO:0006351|GO:0006915|GO:0006355|GO:1901976|GO:1901991|GO:0030071|GO:0071173|GO:0045577|GO:0090231|GO:0010965|GO:0019941|GO:1903506|GO:0090232|GO:0010951|GO:1901799|GO:2000816|GO:1903051|GO:0045579|GO:0061136|GO:0043161|GO:0052548|GO:0032446|GO:0006511|GO:2000117|GO:0031396|GO:0032434|GO:0032435|GO:2000116|GO:0016567 developmental process|immune system process|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular component organization|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|regulation of hemopoiesis|regulation of cell differentiation|cellular aromatic compound metabolic process|positive regulation of cell activation|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|regulation of cell division|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|negative regulation of cell cycle|positive regulation of cell differentiation|positive regulation of leukocyte activation|cell activation|negative regulation of cell division|positive regulation of cell cycle|negative regulation of cell death|nucleobase-containing compound metabolic process|lymphocyte activation|regulation of cell activation|negative regulation of molecular function|regulation of chromosome segregation|cell death|regulation of catalytic activity|chromosome segregation|cell division|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of RNA stability|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of lymphocyte activation|regulation of cellular protein metabolic process|sister chromatid segregation|B cell activation|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|mitotic cell cycle process|macromolecule modification|hemopoiesis|protein catabolic process|lymphocyte differentiation|chromosome separation|negative regulation of programmed cell death|regulation of RNA metabolic process|spleen development|cell cycle phase transition|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|positive regulation of lymphocyte activation|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|negative regulation of hydrolase activity|proteolysis|programmed cell death|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|mitotic nuclear division|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|positive regulation of mitotic cell cycle|negative regulation of protein catabolic process|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|regulation of mRNA stability|negative regulation of cell cycle process|positive regulation of mitotic cell cycle spindle assembly checkpoint|leukocyte differentiation|cellular protein catabolic process|spindle checkpoint|negative regulation of peptidase activity|positive regulation of transcription, DNA-templated|negative regulation of chromosome organization|proteasomal protein catabolic process|B cell differentiation|mitotic cell cycle checkpoint|regulation of mitotic nuclear division|positive regulation of cell cycle checkpoint|RNA biosynthetic process|negative regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of proteolysis|regulation of RNA biosynthetic process|mitotic spindle assembly checkpoint|regulation of lymphocyte differentiation|mitotic spindle checkpoint|regulation of chromosome organization|posttranscriptional regulation of gene expression|regulation of peptidase activity|positive regulation of B cell activation|regulation of mitotic cell cycle spindle assembly checkpoint|regulation of mitotic cell cycle phase transition|proteolysis involved in cellular protein catabolic process|negative regulation of mitotic nuclear division|regulation of B cell activation|mitotic sister chromatid segregation|regulation of apoptotic process|mitotic sister chromatid separation|negative regulation of proteolysis|negative regulation of apoptotic process|regulation of cell cycle phase transition|regulation of ubiquitin-protein transferase activity|metaphase/anaphase transition of mitotic cell cycle|cellular protein modification process|positive regulation of lymphocyte differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of cell cycle checkpoint|negative regulation of mitotic cell cycle phase transition|regulation of mitotic metaphase/anaphase transition|spindle assembly checkpoint|regulation of B cell differentiation|regulation of spindle checkpoint|regulation of mitotic sister chromatid separation|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|positive regulation of spindle checkpoint|negative regulation of endopeptidase activity|negative regulation of proteasomal protein catabolic process|negative regulation of mitotic sister chromatid separation|negative regulation of proteolysis involved in cellular protein catabolic process|positive regulation of B cell differentiation|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of endopeptidase activity|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|negative regulation of cysteine-type endopeptidase activity|regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of cysteine-type endopeptidase activity|protein ubiquitination - - - - 13:113177539-113208715 245 334 442 1154 1140 1032 1.56018645878301 1.93301754540954 2.53773539346923 6.58435968817335 5.9563813235944 6.15911885788208 2.01031313255393 6.23328662321661 -1.63257281573436 1.35943621486977e-13 5.41128116782963e-12 DOWN ENSG00000100280 AP1B1 adaptor related protein complex 1 beta 1 subunit [Source:HGNC Symbol;Acc:HGNC:554] GO:0032502|GO:0032991|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0019882|GO:0043229|GO:0006950|GO:0051641|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0016032|GO:0030119|GO:0007507|GO:0008565|GO:0019884|GO:0006810|GO:0007275|GO:0050688|GO:0048513|GO:0006952|GO:0031982|GO:0030117|GO:0098542|GO:0043231|GO:0019899|GO:0005774|GO:0005737|GO:0007389|GO:0012506|GO:0009615|GO:0030666|GO:0045184|GO:0008104|GO:0061024|GO:0051649|GO:0002504|GO:0051607|GO:0048002|GO:0005794|GO:0016192|GO:0005829|GO:0005802|GO:0072358|GO:0031410|GO:0030131|GO:0015031|GO:0005773|GO:0016023|GO:0030665|GO:0046907|GO:0031988|GO:0034613|GO:0019900|GO:0030118|GO:0030669|GO:0030659|GO:0000139|GO:0072359|GO:0050690|GO:0002495|GO:0030139|GO:0000323|GO:0048193|GO:0006886|GO:0030135|GO:0019886|GO:0009855|GO:0019901|GO:0032588|GO:0005765|GO:0030136|GO:0005764|GO:0007368|GO:0006892|GO:0045334 developmental process|macromolecular complex|transporter activity|immune system process|cell|membrane|cellular process|response to stimulus|binding|antigen processing and presentation|intracellular organelle|response to stress|cellular localization|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|regulation of immune system process|protein binding|protein complex|endomembrane system|anatomical structure development|organelle membrane|viral process|AP-type membrane coat adaptor complex|heart development|protein transporter activity|antigen processing and presentation of exogenous antigen|transport|multicellular organism development|regulation of defense response to virus|animal organ development|defense response|vesicle|membrane coat|defense response to other organism|intracellular membrane-bounded organelle|enzyme binding|vacuolar membrane|cytoplasm|pattern specification process|vesicle membrane|response to virus|endocytic vesicle membrane|establishment of protein localization|protein localization|membrane organization|establishment of localization in cell|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|defense response to virus|antigen processing and presentation of peptide antigen|Golgi apparatus|vesicle-mediated transport|cytosol|trans-Golgi network|cardiovascular system development|cytoplasmic vesicle|clathrin adaptor complex|protein transport|vacuole|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|intracellular transport|membrane-bounded vesicle|cellular protein localization|kinase binding|clathrin coat|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle membrane|Golgi membrane|circulatory system development|regulation of defense response to virus by virus|antigen processing and presentation of peptide antigen via MHC class II|endocytic vesicle|lytic vacuole|Golgi vesicle transport|intracellular protein transport|coated vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class II|determination of bilateral symmetry|protein kinase binding|trans-Golgi network membrane|lysosomal membrane|clathrin-coated vesicle|lysosome|determination of left/right symmetry|post-Golgi vesicle-mediated transport|clathrin-coated endocytic vesicle K12392 AP-1 complex subunit beta-1[-] hsa04142 Lysosome - Homo sapiens (human) 22:29327680-29423179 1014 1076 1358 3336 3914 3149 6.73304664196792 6.49330685125265 8.12994697902092 19.8471235496915 21.3236988574257 19.5963620037157 7.1187668240805 20.2557281369443 -1.50863069530115 1.44570799518616e-13 5.7470261635536e-12 DOWN ENSG00000173950 XXYLT1 xyloside xylosyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:26639] GO:0005623|GO:0016020|GO:0008152|GO:0003824|GO:0043229|GO:0042175|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0043231|GO:0005737|GO:0005783|GO:0016757|GO:0016021|GO:0016763 cell|membrane|metabolic process|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|transferase activity, transferring glycosyl groups|integral component of membrane|transferase activity, transferring pentosyl groups - - - - 3:195068279-195271167 50 53 78 261 281 243 0.348145552643572 0.335392994866478 0.489669707553517 1.62829584856595 1.60534838743795 1.58573492593239 0.391069418354522 1.60645972064543 -2.03838818126049 1.53011677933941e-13 6.07448222478706e-12 DOWN ENSG00000068028 RASSF1 Ras association (RalGDS/AF-6) domain family member 1 [Source:HGNC Symbol;Acc:HGNC:9882] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0042802|GO:0047485|GO:0051726|GO:0007049|GO:0022402|GO:0005874|GO:0031325|GO:0033554|GO:0045786|GO:0043231|GO:0043169|GO:0005737|GO:0045787|GO:0007154|GO:0007165|GO:0031647|GO:0019538|GO:0031323|GO:0032268|GO:0046872|GO:0043412|GO:0050821|GO:0005815|GO:0007050|GO:0036211|GO:0010564|GO:0051247|GO:0032270|GO:0035556|GO:0044267|GO:0051246|GO:0071157|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0006974|GO:0010948|GO:0031401|GO:0071156|GO:0015630|GO:0046914|GO:0007264|GO:0006464|GO:0007265|GO:0008270|GO:0032446|GO:0031398|GO:0031396|GO:0016567 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|identical protein binding|protein N-terminus binding|regulation of cell cycle|cell cycle|cell cycle process|microtubule|positive regulation of cellular metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|cytoplasm|positive regulation of cell cycle|cell communication|signal transduction|regulation of protein stability|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|metal ion binding|macromolecule modification|protein stabilization|microtubule organizing center|cell cycle arrest|protein modification process|regulation of cell cycle process|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of protein metabolic process|negative regulation of cell cycle arrest|cytoskeleton|spindle pole|nucleus|spindle|cellular response to DNA damage stimulus|negative regulation of cell cycle process|positive regulation of protein modification process|regulation of cell cycle arrest|microtubule cytoskeleton|transition metal ion binding|small GTPase mediated signal transduction|cellular protein modification process|Ras protein signal transduction|zinc ion binding|protein modification by small protein conjugation|positive regulation of protein ubiquitination|regulation of protein ubiquitination|protein ubiquitination K09850 Ras association domain-containing protein 1[-] hsa05200|hsa05206|hsa04014|hsa04390|hsa05223|hsa05219 Pathways in cancer - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Bladder cancer - Homo sapiens (human) 3:50329782-50340980 676 654 525 182 225 190 4.94193276407835 4.34517945525291 3.4603737283484 1.19211765865767 1.34958541087565 1.30176136732899 4.24916198255989 1.28115481228744 1.72973352305217 1.54047209813978e-13 6.10747065310292e-12 UP ENSG00000224531 SMIM13 small integral membrane protein 13 [Source:HGNC Symbol;Acc:HGNC:27356] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 6:11094033-11138733 1378 1457 1298 521 599 437 16.4127555964129 15.771468471543 13.9386724270777 5.55990943583938 5.85365853089785 4.8780160971685 15.3742988316779 5.43052802130191 1.50135622950672 1.54484512040997e-13 6.1166851756922e-12 UP ENSG00000118961 LDAH lipid droplet associated hydrolase [Source:HGNC Symbol;Acc:HGNC:26145] GO:0005623|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0043227|GO:0016787|GO:0005622|GO:0012505|GO:0016788|GO:0043231|GO:0005737|GO:0006629|GO:0005783|GO:0019915|GO:0010876|GO:0016042|GO:0005811|GO:0016298 cell|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|membrane-bounded organelle|hydrolase activity|intracellular|endomembrane system|hydrolase activity, acting on ester bonds|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|endoplasmic reticulum|lipid storage|lipid localization|lipid catabolic process|lipid particle|lipase activity - - - - 2:20684014-20823130 65 73 79 275 342 272 0.383607000246277 0.39154042019272 0.420354245387098 1.45412358950985 1.65602202532583 1.50442009667547 0.398500555275365 1.53818857050372 -1.94857873824933 1.64513577741015e-13 6.50515013229173e-12 DOWN ENSG00000139624 CERS5 ceramide synthase 5 [Source:HGNC Symbol;Acc:HGNC:23749] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0003676|GO:0034641|GO:0044281|GO:0043231|GO:0016746|GO:0005737|GO:0005635|GO:0006629|GO:0005783|GO:0031965|GO:0016021|GO:0044249|GO:0003677|GO:0006665|GO:0006643|GO:0016747|GO:0043603|GO:0008610|GO:0005634|GO:0006672|GO:0016410|GO:0030148|GO:0046513|GO:0050291 cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|nuclear envelope|lipid metabolic process|endoplasmic reticulum|nuclear membrane|integral component of membrane|cellular biosynthetic process|DNA binding|sphingolipid metabolic process|membrane lipid metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|cellular amide metabolic process|lipid biosynthetic process|nucleus|ceramide metabolic process|N-acyltransferase activity|sphingolipid biosynthetic process|ceramide biosynthetic process|sphingosine N-acyltransferase activity K04710 ceramide synthetase[2.3.1.24] hsa01100|hsa04071|hsa00600 Metabolic pathways - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human) 12:50129306-50167533 55 34 89 338 309 355 0.208763233232524 0.117287415254795 0.304576076240779 1.14949682768714 0.962320625893796 1.26284617474816 0.210208908242699 1.1248878761097 -2.41988549278938 1.65894745008706e-13 6.55108692789668e-12 DOWN ENSG00000143819 EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) [Source:HGNC Symbol;Acc:HGNC:3401] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0043229|GO:0042175|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0006725|GO:0009410|GO:0044281|GO:0043231|GO:0005737|GO:0005783|GO:0006805|GO:0016021|GO:0010033|GO:0009636|GO:0071466|GO:0014070|GO:0019439|GO:0033961|GO:0004301 cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|response to xenobiotic stimulus|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|xenobiotic metabolic process|integral component of membrane|response to organic substance|response to toxic substance|cellular response to xenobiotic stimulus|response to organic cyclic compound|aromatic compound catabolic process|cis-stilbene-oxide hydrolase activity|epoxide hydrolase activity K01253 microsomal epoxide hydrolase[3.3.2.9] hsa05204|hsa00980|hsa04976 Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Bile secretion - Homo sapiens (human) 1:225810092-225845563 1804 1876 1957 5579 5528 6037 34.9423086100467 33.0238667163969 34.1759064793023 96.8208879422772 87.8518671719037 109.588533211479 34.0473606019153 98.0870961085533 -1.52652039166738 1.66192729634615e-13 6.5541846109799e-12 DOWN ENSG00000117000 RLF rearranged L-myc fusion [Source:HGNC Symbol;Acc:HGNC:10025] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010628|GO:0006259|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0015074|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0008270 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|positive regulation of gene expression|DNA metabolic process|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|DNA integration|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 1:40161373-40240921 1753 1885 2014 693 781 826 19.8529832982968 19.4014916013985 20.5644667473093 7.03192828667201 7.25709155440102 8.76704071782493 19.9396472156682 7.68535351963265 1.37545635564378 1.78144053672924e-13 7.01624350705999e-12 UP ENSG00000186806 VSIG10L V-set and immunoglobulin domain containing 10 like [Source:HGNC Symbol;Acc:HGNC:27111] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 19:51331536-51342124 555 654 694 1893 2031 3076 8.545700829849 9.1519278208592 9.63448701865599 26.1157776400246 25.6585766047354 44.3884524079793 9.1107052231214 32.0542688842464 -1.8148818664215 1.79291158230293e-13 7.05211889039154e-12 DOWN ENSG00000151348 EXT2 exostosin glycosyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:3513] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0031090|GO:0006486|GO:0044262|GO:0009888|GO:0043541|GO:0006082|GO:0007275|GO:0044281|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0048729|GO:0046983|GO:0048598|GO:0007154|GO:0001704|GO:0007165|GO:0005783|GO:0070062|GO:0001503|GO:0016757|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0005976|GO:0034645|GO:0046872|GO:0043412|GO:0015012|GO:0007498|GO:0046982|GO:0008194|GO:0009790|GO:0009100|GO:0036211|GO:0007369|GO:0016758|GO:0001707|GO:0033692|GO:0030201|GO:0070085|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0030154|GO:0016051|GO:0048332|GO:0009101|GO:0043413|GO:0000271|GO:0008375|GO:0015020|GO:0015014|GO:0006024|GO:0006029|GO:0030203|GO:0006464|GO:0050508|GO:0050509|GO:0042328|GO:0030166 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|protein glycosylation|cellular carbohydrate metabolic process|tissue development|UDP-N-acetylglucosamine transferase complex|organic acid metabolic process|multicellular organism development|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|cell communication|formation of primary germ layer|signal transduction|endoplasmic reticulum|extracellular exosome|ossification|transferase activity, transferring glycosyl groups|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|polysaccharide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|heparan sulfate proteoglycan biosynthetic process|mesoderm development|protein heterodimerization activity|UDP-glycosyltransferase activity|embryo development|glycoprotein metabolic process|protein modification process|gastrulation|transferase activity, transferring hexosyl groups|mesoderm formation|cellular polysaccharide biosynthetic process|heparan sulfate proteoglycan metabolic process|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|cell differentiation|carbohydrate biosynthetic process|mesoderm morphogenesis|glycoprotein biosynthetic process|macromolecule glycosylation|polysaccharide biosynthetic process|acetylglucosaminyltransferase activity|glucuronosyltransferase activity|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|glycosaminoglycan metabolic process|cellular protein modification process|glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|proteoglycan biosynthetic process K02367 glucuronyl/N-acetylglucosaminyl transferase EXT2[2.4.1.225] hsa01100|hsa00534 Metabolic pathways - Homo sapiens (human)|Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human) 11:44095549-44245429 794 896 1078 2599 2784 2801 5.33077383806474 5.46711119135934 6.52533578653248 15.6341391134986 15.3358276363057 17.6243084517247 5.77440693865219 16.198091733843 -1.48807917494646 1.85524768231472e-13 7.2877058299768e-12 DOWN ENSG00000176390 CRLF3 cytokine receptor-like factor 3 [Source:HGNC Symbol;Acc:HGNC:17177] GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0023051|GO:0045926|GO:0016043|GO:0071944|GO:0040008|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0045786|GO:0030308|GO:0005737|GO:0009966|GO:0045787|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0016021|GO:0009967|GO:0044249|GO:0001558|GO:0031323|GO:1902533|GO:0010468|GO:0034645|GO:0090068|GO:1903047|GO:0051252|GO:0044770|GO:0007050|GO:0010628|GO:0000278|GO:0010564|GO:0035556|GO:0010467|GO:0031328|GO:0009059|GO:1902531|GO:0016070|GO:0010557|GO:0045893|GO:0071156|GO:0032774|GO:0044772|GO:2001141|GO:0006351|GO:0006355|GO:0071158|GO:0045944|GO:0006366|GO:0007259|GO:0006357|GO:1903506|GO:0046425|GO:0000082|GO:0046427 growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|regulation of signaling|negative regulation of growth|cellular component organization|cell periphery|regulation of growth|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|negative regulation of cell cycle|negative regulation of cell growth|cytoplasm|regulation of signal transduction|positive regulation of cell cycle|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|regulation of cell growth|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|regulation of gene expression|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|mitotic cell cycle process|regulation of RNA metabolic process|cell cycle phase transition|cell cycle arrest|positive regulation of gene expression|mitotic cell cycle|regulation of cell cycle process|intracellular signal transduction|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|positive regulation of transcription, DNA-templated|regulation of cell cycle arrest|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|regulation of JAK-STAT cascade|G1/S transition of mitotic cell cycle|positive regulation of JAK-STAT cascade - - - - 17:30769388-30824776 644 790 903 295 311 308 8.09139163214618 9.02078676585802 10.2291437149331 3.32091339182981 3.20601696589282 3.62674035157223 9.11377403764577 3.38455690309829 1.42908162905849 1.86496638286028e-13 7.31625576792522e-12 UP ENSG00000138758 SEPT11 septin 11 [Source:HGNC Symbol;Acc:HGNC:25589] GO:0045202|GO:0005623|GO:0009987|GO:0005576|GO:0030054|GO:0005488|GO:0036094|GO:1903561|GO:0042995|GO:0097159|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0007049|GO:0043168|GO:0001882|GO:0031982|GO:0022607|GO:0005737|GO:0043005|GO:0043197|GO:0036477|GO:0070062|GO:0000166|GO:0051301|GO:0035639|GO:0030424|GO:0044309|GO:0001883|GO:0032432|GO:0032549|GO:0030425|GO:0006461|GO:0042641|GO:0017076|GO:0005856|GO:0015629|GO:0032561|GO:0051259|GO:0001725|GO:0005525|GO:0019001|GO:0051291 synapse|cell|cellular process|extracellular region|cell junction|binding|small molecule binding|extracellular vesicle|cell projection|organic cyclic compound binding|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|intracellular|protein binding|cell cycle|anion binding|nucleoside binding|vesicle|cellular component assembly|cytoplasm|neuron projection|dendritic spine|somatodendritic compartment|extracellular exosome|nucleotide binding|cell division|purine ribonucleoside triphosphate binding|axon|neuron spine|purine nucleoside binding|actin filament bundle|ribonucleoside binding|dendrite|protein complex assembly|actomyosin|purine nucleotide binding|cytoskeleton|actin cytoskeleton|guanyl ribonucleotide binding|protein oligomerization|stress fiber|GTP binding|guanyl nucleotide binding|protein heterooligomerization K16939 septin 6/8/11[-] hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) 4:76949703-77040384 491 596 652 1785 1981 1562 2.61200291801136 2.88149905154856 3.1271882325485 8.5080098420383 8.64658330545335 7.78756932857559 2.87356340070281 8.31405415868908 -1.53271126552702 1.87194985889702e-13 7.33401457841359e-12 DOWN ENSG00000104856 RELB v-rel avian reticuloendotheliosis viral oncogene homolog B [Source:HGNC Symbol;Acc:HGNC:9956] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0045321|GO:0019882|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0071704|GO:0006955|GO:0009628|GO:0044237|GO:0000989|GO:0007155|GO:0043227|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0001818|GO:0002757|GO:0002250|GO:0016337|GO:0002286|GO:0045087|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0070489|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0032922|GO:0001817|GO:0098609|GO:0033256|GO:0043231|GO:0005737|GO:0000981|GO:0002218|GO:0001816|GO:0001775|GO:0002263|GO:0009890|GO:0003682|GO:0006139|GO:0050776|GO:0046649|GO:0007154|GO:0007165|GO:0002366|GO:0050778|GO:0006970|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0002292|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0032479|GO:0007166|GO:0030097|GO:0002758|GO:0034097|GO:0030098|GO:0010629|GO:0051252|GO:0005815|GO:0010628|GO:0006954|GO:0002429|GO:0031981|GO:0071470|GO:0032480|GO:0007159|GO:0032606|GO:0005654|GO:0002764|GO:0002460|GO:0042110|GO:0035556|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0042093|GO:0016070|GO:0001773|GO:0005856|GO:0010557|GO:0005634|GO:0045089|GO:0045088|GO:0032688|GO:0002521|GO:0043011|GO:0000975|GO:0045893|GO:0019221|GO:0045892|GO:0038061|GO:0032774|GO:0043565|GO:2001141|GO:0030217|GO:0002768|GO:1902679|GO:0070486|GO:0003690|GO:0046631|GO:0015630|GO:0007249|GO:0032608|GO:0071345|GO:0042088|GO:0034612|GO:0030099|GO:0045063|GO:0032648|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0097028|GO:0002573|GO:0002223|GO:1903507|GO:0006357|GO:0046632|GO:0071356|GO:1903506|GO:0044212|GO:0033209|GO:0035710|GO:0000122|GO:0071593|GO:0001047|GO:0000976|GO:0001012|GO:0043367|GO:0000977 developmental process|macromolecular complex|immune system process|signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|leukocyte activation|antigen processing and presentation|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|organic substance metabolic process|immune response|response to abiotic stimulus|cellular metabolic process|transcription factor activity, transcription factor binding|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|negative regulation of cytokine production|immune response-activating signal transduction|adaptive immune response|single organismal cell-cell adhesion|T cell activation involved in immune response|innate immune response|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|circadian regulation of gene expression|regulation of cytokine production|cell-cell adhesion|I-kappaB/NF-kappaB complex|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|cytokine production|cell activation|cell activation involved in immune response|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|regulation of immune response|lymphocyte activation|cell communication|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|response to osmotic stress|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|T cell differentiation involved in immune response|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|regulation of type I interferon production|cell surface receptor signaling pathway|hemopoiesis|innate immune response-activating signal transduction|response to cytokine|lymphocyte differentiation|negative regulation of gene expression|regulation of RNA metabolic process|microtubule organizing center|positive regulation of gene expression|inflammatory response|immune response-activating cell surface receptor signaling pathway|nuclear lumen|cellular response to osmotic stress|negative regulation of type I interferon production|leukocyte cell-cell adhesion|type I interferon production|nucleoplasm|immune response-regulating signaling pathway|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|T cell activation|intracellular signal transduction|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|T-helper cell differentiation|RNA metabolic process|myeloid dendritic cell activation|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of innate immune response|regulation of innate immune response|negative regulation of interferon-beta production|leukocyte differentiation|myeloid dendritic cell differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|negative regulation of transcription, DNA-templated|NIK/NF-kappaB signaling|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|T cell differentiation|immune response-regulating cell surface receptor signaling pathway|negative regulation of RNA biosynthetic process|leukocyte aggregation|double-stranded DNA binding|alpha-beta T cell activation|microtubule cytoskeleton|I-kappaB kinase/NF-kappaB signaling|interferon-beta production|cellular response to cytokine stimulus|T-helper 1 type immune response|response to tumor necrosis factor|myeloid cell differentiation|T-helper 1 cell differentiation|regulation of interferon-beta production|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|dendritic cell differentiation|myeloid leukocyte differentiation|stimulatory C-type lectin receptor signaling pathway|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|alpha-beta T cell differentiation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|tumor necrosis factor-mediated signaling pathway|CD4-positive, alpha-beta T cell activation|negative regulation of transcription from RNA polymerase II promoter|lymphocyte aggregation|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|CD4-positive, alpha-beta T cell differentiation|RNA polymerase II regulatory region sequence-specific DNA binding K09253 transcription factor RelB[-] hsa05166|hsa04010|hsa05169|hsa04380|hsa04064 HTLV-I infection - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human) 19:45001430-45038198 675 769 641 242 280 190 6.91089517032848 7.15545325991866 5.91702080335945 2.21995272617711 2.35210175718595 1.82310652630993 6.66112307786886 2.13172033655766 1.64374725761564 1.87914226972632e-13 7.34292059167663e-12 UP ENSG00000156831 NSMCE2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase [Source:HGNC Symbol;Acc:HGNC:26513] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:0051130|GO:1901360|GO:0051302|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0030915|GO:0043231|GO:0000723|GO:0043169|GO:0042592|GO:0045787|GO:0006139|GO:0051983|GO:0019787|GO:0007059|GO:0051781|GO:0051301|GO:0048869|GO:0051984|GO:0019538|GO:0031323|GO:0006996|GO:0007568|GO:0051276|GO:0032268|GO:0045732|GO:0000819|GO:0090068|GO:0046872|GO:0000725|GO:1903047|GO:0043412|GO:0030163|GO:0051304|GO:0019789|GO:0000722|GO:0044770|GO:0044265|GO:0006302|GO:0036211|GO:0000278|GO:0007569|GO:0031981|GO:0007062|GO:0007346|GO:0010564|GO:0051247|GO:0006508|GO:0005654|GO:0006259|GO:0005694|GO:0032270|GO:0033043|GO:0044267|GO:0042176|GO:0007067|GO:1901970|GO:0045876|GO:0051246|GO:0045931|GO:0005634|GO:0090398|GO:0006974|GO:0010638|GO:2001252|GO:0044257|GO:0000724|GO:0007063|GO:0032200|GO:0000781|GO:0010498|GO:0007088|GO:1903364|GO:0000793|GO:0044772|GO:0030162|GO:0007064|GO:0045862|GO:0033044|GO:0016604|GO:1901990|GO:1901989|GO:0051603|GO:1901992|GO:0006310|GO:0000070|GO:0045840|GO:0051306|GO:0046914|GO:1901987|GO:0045842|GO:0007091|GO:0006464|GO:0034088|GO:0030071|GO:1903052|GO:0010965|GO:0019941|GO:1901800|GO:0018193|GO:0006312|GO:0016605|GO:0043687|GO:0034184|GO:0061136|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0032436|GO:0018205|GO:0016925 developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|ligase activity|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell division|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|Smc5-Smc6 complex|intracellular membrane-bounded organelle|telomere maintenance|cation binding|homeostatic process|positive regulation of cell cycle|nucleobase-containing compound metabolic process|regulation of chromosome segregation|ubiquitin-like protein transferase activity|chromosome segregation|positive regulation of cell division|cell division|cellular developmental process|positive regulation of chromosome segregation|protein metabolic process|regulation of cellular metabolic process|organelle organization|aging|chromosome organization|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|sister chromatid segregation|positive regulation of cell cycle process|metal ion binding|recombinational repair|mitotic cell cycle process|macromolecule modification|protein catabolic process|chromosome separation|SUMO transferase activity|telomere maintenance via recombination|cell cycle phase transition|cellular macromolecule catabolic process|double-strand break repair|protein modification process|mitotic cell cycle|cell aging|nuclear lumen|sister chromatid cohesion|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|proteolysis|nucleoplasm|DNA metabolic process|chromosome|positive regulation of cellular protein metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|mitotic nuclear division|positive regulation of mitotic sister chromatid separation|positive regulation of sister chromatid cohesion|regulation of protein metabolic process|positive regulation of mitotic cell cycle|nucleus|cellular senescence|cellular response to DNA damage stimulus|positive regulation of organelle organization|positive regulation of chromosome organization|cellular protein catabolic process|double-strand break repair via homologous recombination|regulation of sister chromatid cohesion|telomere organization|chromosome, telomeric region|proteasomal protein catabolic process|regulation of mitotic nuclear division|positive regulation of cellular protein catabolic process|condensed chromosome|mitotic cell cycle phase transition|regulation of proteolysis|mitotic sister chromatid cohesion|positive regulation of proteolysis|regulation of chromosome organization|nuclear body|regulation of mitotic cell cycle phase transition|positive regulation of cell cycle phase transition|proteolysis involved in cellular protein catabolic process|positive regulation of mitotic cell cycle phase transition|DNA recombination|mitotic sister chromatid segregation|positive regulation of mitotic nuclear division|mitotic sister chromatid separation|transition metal ion binding|regulation of cell cycle phase transition|positive regulation of mitotic metaphase/anaphase transition|metaphase/anaphase transition of mitotic cell cycle|cellular protein modification process|maintenance of mitotic sister chromatid cohesion|regulation of mitotic metaphase/anaphase transition|positive regulation of proteolysis involved in cellular protein catabolic process|regulation of mitotic sister chromatid separation|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|peptidyl-amino acid modification|mitotic recombination|PML body|post-translational protein modification|positive regulation of maintenance of mitotic sister chromatid cohesion|regulation of proteasomal protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|peptidyl-lysine modification|protein sumoylation - - - - 8:125091679-125367120 101 111 214 616 579 645 1.12334186996598 1.12200015022556 2.14593858263019 6.13856269235177 5.28366013114886 6.72321777384571 1.46376020094058 6.04848019911545 -2.04689345721635 1.87819246257203e-13 7.34292059167663e-12 DOWN ENSG00000011376 LARS2 leucyl-tRNA synthetase 2 [Source:HGNC Symbol;Acc:HGNC:17095] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0016874|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0016788|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0006139|GO:0006450|GO:0000166|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0035639|GO:0001883|GO:0032549|GO:0005759|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0051246|GO:0009059|GO:0016070|GO:0016876|GO:0052689|GO:0043043|GO:0002161|GO:0043039|GO:0005524|GO:0034660|GO:0030554|GO:0010608|GO:0006412|GO:0006417|GO:0019752|GO:0004812|GO:0006414|GO:0006418|GO:0006399|GO:0004823|GO:0006429 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|ligase activity|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|regulation of translational fidelity|nucleotide binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|mitochondrial matrix|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|ligase activity, forming aminoacyl-tRNA and related compounds|carboxylic ester hydrolase activity|peptide biosynthetic process|aminoacyl-tRNA editing activity|tRNA aminoacylation|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|posttranscriptional regulation of gene expression|translation|regulation of translation|carboxylic acid metabolic process|aminoacyl-tRNA ligase activity|translational elongation|tRNA aminoacylation for protein translation|tRNA metabolic process|leucine-tRNA ligase activity|leucyl-tRNA aminoacylation K01869 leucyl-tRNA synthetase[6.1.1.4] hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) 3:45388506-45549421 88 93 155 525 554 379 0.765942978126506 0.735665007753332 1.21636082690446 4.0942322566602 3.95633531184154 3.09160462063778 0.905989604261433 3.71405739637984 -2.03542970925996 1.93409561985758e-13 7.5477765536246e-12 DOWN ENSG00000104312 RIPK2 receptor interacting serine/threonine kinase 2 [Source:HGNC Symbol;Acc:HGNC:10020] GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0006914|GO:0023051|GO:0051707|GO:0007155|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0042802|GO:0008284|GO:0002757|GO:0042127|GO:0002250|GO:1903706|GO:0016337|GO:0002286|GO:0010506|GO:0045087|GO:0045595|GO:0006725|GO:0070661|GO:0060760|GO:0050867|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0048513|GO:0070489|GO:0005102|GO:0034641|GO:0043168|GO:0006952|GO:0030155|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0098542|GO:0001817|GO:0098609|GO:0045597|GO:0010243|GO:0005737|GO:0002218|GO:0001816|GO:0010508|GO:0002696|GO:0001775|GO:0009966|GO:0046983|GO:0002263|GO:0001819|GO:0019904|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0009617|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:1904417|GO:0007165|GO:0002366|GO:0050778|GO:0045785|GO:0008219|GO:0016236|GO:0050790|GO:0000166|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0002292|GO:0051090|GO:0032735|GO:0000165|GO:1902533|GO:0051249|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0032943|GO:0032479|GO:0098792|GO:0007166|GO:0001959|GO:0033993|GO:0035639|GO:0032675|GO:0043412|GO:0030097|GO:0002758|GO:0034097|GO:0030098|GO:0032623|GO:0032635|GO:0002237|GO:0032642|GO:0043069|GO:0051252|GO:0001883|GO:0034109|GO:0032655|GO:1901652|GO:0045622|GO:0032481|GO:0071417|GO:0010628|GO:0032755|GO:0032615|GO:0051347|GO:0036211|GO:0001961|GO:0043331|GO:0071219|GO:0006954|GO:0016239|GO:0032549|GO:0032602|GO:0016241|GO:0051251|GO:0051091|GO:0002429|GO:0032743|GO:0022407|GO:0031098|GO:0007159|GO:0032606|GO:0051247|GO:0070848|GO:0002764|GO:0016301|GO:0002821|GO:0002460|GO:0032270|GO:0042110|GO:0012501|GO:0014070|GO:0006796|GO:0035556|GO:0044267|GO:0032609|GO:0051174|GO:0045624|GO:0010467|GO:0050700|GO:0071310|GO:0017076|GO:0002819|GO:0032494|GO:0031328|GO:0051246|GO:0042742|GO:0046651|GO:0009059|GO:0030154|GO:0022409|GO:0042093|GO:0043068|GO:0032729|GO:1902531|GO:0016070|GO:0030274|GO:0031667|GO:0016773|GO:0005856|GO:0010557|GO:0032496|GO:0042803|GO:0043067|GO:0045089|GO:0032722|GO:0030522|GO:0045088|GO:0032649|GO:0032680|GO:0002521|GO:0070304|GO:0032607|GO:0042098|GO:0032727|GO:0045893|GO:0070671|GO:0045627|GO:0071224|GO:0019221|GO:0045625|GO:0031401|GO:0050863|GO:0070555|GO:0043122|GO:0043065|GO:0032495|GO:1901653|GO:0043408|GO:0032774|GO:0005524|GO:0032728|GO:2001141|GO:0030217|GO:0071363|GO:0030554|GO:0016310|GO:0045619|GO:0051092|GO:0002768|GO:0038179|GO:0034112|GO:0070371|GO:0032640|GO:0035872|GO:0002221|GO:0070673|GO:0070486|GO:0046631|GO:0007167|GO:0043123|GO:0050830|GO:0007249|GO:0043410|GO:0032608|GO:0032872|GO:0042981|GO:0071345|GO:0043066|GO:0004672|GO:0042088|GO:0032760|GO:0045063|GO:0043330|GO:0006464|GO:0050870|GO:0050851|GO:0032648|GO:0071396|GO:0045621|GO:0051403|GO:0050671|GO:0043549|GO:0006351|GO:0071223|GO:0006915|GO:0006355|GO:0071222|GO:1903039|GO:0033674|GO:0032946|GO:0031663|GO:0048011|GO:0045582|GO:0045944|GO:0006366|GO:0045859|GO:0045860|GO:0002224|GO:0043406|GO:0046328|GO:0006357|GO:0006468|GO:0046632|GO:0045580|GO:1903506|GO:0043405|GO:0042325|GO:0004713|GO:0070374|GO:0007254|GO:0001932|GO:0070423|GO:0018193|GO:0004674|GO:0032874|GO:0001934|GO:0071225|GO:0050852|GO:0042129|GO:0035710|GO:0070372|GO:0071593|GO:0042327|GO:0042102|GO:0046633|GO:0007169|GO:0002827|GO:0004715|GO:0032446|GO:0050731|GO:0046330|GO:0033091|GO:0031398|GO:0050730|GO:0034166|GO:0034134|GO:0038124|GO:0046638|GO:0046641|GO:0070427|GO:0000187|GO:0033138|GO:0070431|GO:0002756|GO:0031396|GO:0071902|GO:0018105|GO:0034138|GO:0002755|GO:0034146|GO:0033135|GO:0071900|GO:0018107|GO:0034142|GO:0043367|GO:0038123|GO:2000516|GO:0034162|GO:0032147|GO:0018108|GO:0010800|GO:0043372|GO:0043370|GO:0016567|GO:0035666 developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|autophagy|regulation of signaling|response to other organism|cell adhesion|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|identical protein binding|positive regulation of cell proliferation|immune response-activating signal transduction|regulation of cell proliferation|adaptive immune response|regulation of hemopoiesis|single organismal cell-cell adhesion|T cell activation involved in immune response|regulation of autophagy|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|leukocyte proliferation|positive regulation of response to cytokine stimulus|positive regulation of cell activation|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|animal organ development|T cell aggregation|receptor binding|cellular nitrogen compound metabolic process|anion binding|defense response|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|defense response to other organism|regulation of cytokine production|cell-cell adhesion|positive regulation of cell differentiation|response to organonitrogen compound|cytoplasm|activation of innate immune response|cytokine production|positive regulation of autophagy|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|protein dimerization activity|cell activation involved in immune response|positive regulation of cytokine production|protein domain specific binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|positive regulation of xenophagy|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|positive regulation of cell adhesion|cell death|macroautophagy|regulation of catalytic activity|nucleotide binding|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|T cell differentiation involved in immune response|regulation of sequence-specific DNA binding transcription factor activity|positive regulation of interleukin-12 production|MAPK cascade|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|mononuclear cell proliferation|regulation of type I interferon production|xenophagy|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|response to lipid|purine ribonucleoside triphosphate binding|regulation of interleukin-6 production|macromolecule modification|hemopoiesis|innate immune response-activating signal transduction|response to cytokine|lymphocyte differentiation|interleukin-2 production|interleukin-6 production|response to molecule of bacterial origin|regulation of chemokine production|negative regulation of programmed cell death|regulation of RNA metabolic process|purine nucleoside binding|homotypic cell-cell adhesion|regulation of interleukin-12 production|response to peptide|regulation of T-helper cell differentiation|positive regulation of type I interferon production|cellular response to organonitrogen compound|positive regulation of gene expression|positive regulation of interleukin-6 production|interleukin-12 production|positive regulation of transferase activity|protein modification process|positive regulation of cytokine-mediated signaling pathway|response to dsRNA|cellular response to molecule of bacterial origin|inflammatory response|positive regulation of macroautophagy|ribonucleoside binding|chemokine production|regulation of macroautophagy|positive regulation of lymphocyte activation|positive regulation of sequence-specific DNA binding transcription factor activity|immune response-activating cell surface receptor signaling pathway|positive regulation of interleukin-2 production|regulation of cell-cell adhesion|stress-activated protein kinase signaling cascade|leukocyte cell-cell adhesion|type I interferon production|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|kinase activity|positive regulation of adaptive immune response|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|interferon-gamma production|regulation of phosphorus metabolic process|positive regulation of T-helper cell differentiation|gene expression|CARD domain binding|cellular response to organic substance|purine nucleotide binding|regulation of adaptive immune response|response to peptidoglycan|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|defense response to bacterium|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|T-helper cell differentiation|positive regulation of programmed cell death|positive regulation of interferon-gamma production|regulation of intracellular signal transduction|RNA metabolic process|LIM domain binding|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|protein homodimerization activity|regulation of programmed cell death|positive regulation of innate immune response|positive regulation of chemokine production|intracellular receptor signaling pathway|regulation of innate immune response|regulation of interferon-gamma production|regulation of tumor necrosis factor production|leukocyte differentiation|positive regulation of stress-activated protein kinase signaling cascade|interferon-alpha production|T cell proliferation|positive regulation of interferon-alpha production|positive regulation of transcription, DNA-templated|response to interleukin-12|positive regulation of T-helper 1 cell differentiation|cellular response to peptidoglycan|cytokine-mediated signaling pathway|regulation of T-helper 1 cell differentiation|positive regulation of protein modification process|regulation of T cell activation|response to interleukin-1|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of apoptotic process|response to muramyl dipeptide|cellular response to peptide|regulation of MAPK cascade|RNA biosynthetic process|ATP binding|positive regulation of interferon-beta production|regulation of RNA biosynthetic process|T cell differentiation|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|regulation of lymphocyte differentiation|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|positive regulation of homotypic cell-cell adhesion|ERK1 and ERK2 cascade|tumor necrosis factor production|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|pattern recognition receptor signaling pathway|response to interleukin-18|leukocyte aggregation|alpha-beta T cell activation|enzyme linked receptor protein signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|defense response to Gram-positive bacterium|I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|interferon-beta production|regulation of stress-activated MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|protein kinase activity|T-helper 1 type immune response|positive regulation of tumor necrosis factor production|T-helper 1 cell differentiation|response to exogenous dsRNA|cellular protein modification process|positive regulation of T cell activation|antigen receptor-mediated signaling pathway|regulation of interferon-beta production|cellular response to lipid|positive regulation of lymphocyte differentiation|stress-activated MAPK cascade|positive regulation of lymphocyte proliferation|regulation of kinase activity|transcription, DNA-templated|cellular response to lipoteichoic acid|apoptotic process|regulation of transcription, DNA-templated|cellular response to lipopolysaccharide|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|positive regulation of mononuclear cell proliferation|lipopolysaccharide-mediated signaling pathway|neurotrophin TRK receptor signaling pathway|positive regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|alpha-beta T cell differentiation|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|protein tyrosine kinase activity|positive regulation of ERK1 and ERK2 cascade|JNK cascade|regulation of protein phosphorylation|nucleotide-binding oligomerization domain containing signaling pathway|peptidyl-amino acid modification|protein serine/threonine kinase activity|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|cellular response to muramyl dipeptide|T cell receptor signaling pathway|regulation of T cell proliferation|CD4-positive, alpha-beta T cell activation|regulation of ERK1 and ERK2 cascade|lymphocyte aggregation|positive regulation of phosphorylation|positive regulation of T cell proliferation|alpha-beta T cell proliferation|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of T-helper 1 type immune response|non-membrane spanning protein tyrosine kinase activity|protein modification by small protein conjugation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of JNK cascade|positive regulation of immature T cell proliferation|positive regulation of protein ubiquitination|regulation of peptidyl-tyrosine phosphorylation|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|positive regulation of alpha-beta T cell differentiation|positive regulation of alpha-beta T cell proliferation|nucleotide-binding oligomerization domain containing 1 signaling pathway|activation of MAPK activity|positive regulation of peptidyl-serine phosphorylation|nucleotide-binding oligomerization domain containing 2 signaling pathway|MyD88-independent toll-like receptor signaling pathway|regulation of protein ubiquitination|positive regulation of protein serine/threonine kinase activity|peptidyl-serine phosphorylation|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|regulation of peptidyl-serine phosphorylation|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|toll-like receptor 4 signaling pathway|CD4-positive, alpha-beta T cell differentiation|toll-like receptor TLR1:TLR2 signaling pathway|positive regulation of CD4-positive, alpha-beta T cell activation|toll-like receptor 9 signaling pathway|activation of protein kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of CD4-positive, alpha-beta T cell differentiation|regulation of CD4-positive, alpha-beta T cell differentiation|protein ubiquitination|TRIF-dependent toll-like receptor signaling pathway K08846 receptor-interacting serine/threonine-protein kinase 2[2.7.11.1] hsa05152|hsa04722|hsa05131|hsa04621 Tuberculosis - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|NOD-like receptor signaling pathway - Homo sapiens (human) 8:89757747-89791063 2281 2184 1972 774 926 604 35.1144238743122 30.5557454382231 27.370413028985 10.6757590520516 11.6960518661341 8.71416689824162 31.0135274471734 10.3619926054758 1.58159616678939 1.97280223202136e-13 7.68877778521746e-12 UP ENSG00000198668 CALM1 calmodulin 1 (phosphorylase kinase, delta) [Source:HGNC Symbol;Acc:HGNC:1442] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0051606|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0030427|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0030017|GO:0047485|GO:0060341|GO:0044262|GO:0002757|GO:0051726|GO:0007049|GO:0051282|GO:0050817|GO:0006935|GO:0045087|GO:0006725|GO:0048468|GO:0009314|GO:0044325|GO:0006810|GO:0022402|GO:1901360|GO:0007275|GO:0019208|GO:0010524|GO:0048513|GO:0048857|GO:0043647|GO:0051302|GO:0005102|GO:0034641|GO:0015980|GO:0008047|GO:0005874|GO:0044281|GO:0032940|GO:0006952|GO:2001057|GO:0043270|GO:0016772|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0030426|GO:0007420|GO:0009582|GO:0043231|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0003012|GO:0002218|GO:0007267|GO:0009611|GO:0060322|GO:0005975|GO:0006928|GO:0042592|GO:0072593|GO:0001775|GO:0043005|GO:0009966|GO:0048306|GO:0019725|GO:0030901|GO:0019904|GO:0032387|GO:0032388|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0055086|GO:0030235|GO:1902495|GO:0007154|GO:0044092|GO:0055085|GO:0061024|GO:0009593|GO:0007165|GO:0050778|GO:0010523|GO:0009968|GO:0070062|GO:0051649|GO:0008092|GO:2000021|GO:0009725|GO:0050790|GO:0030030|GO:0006091|GO:0032410|GO:0051238|GO:0043548|GO:0002027|GO:0051301|GO:0019207|GO:0048869|GO:0016021|GO:0010035|GO:0009967|GO:0044249|GO:1903779|GO:0010469|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0050878|GO:0032411|GO:0003013|GO:0034763|GO:0043271|GO:0055114|GO:0051284|GO:0071774|GO:0000165|GO:0016192|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0005813|GO:0005976|GO:0007186|GO:0006936|GO:0030168|GO:0005513|GO:0046872|GO:0007166|GO:0033993|GO:0051349|GO:0043412|GO:0009583|GO:0002758|GO:0031996|GO:0061337|GO:0007417|GO:0051345|GO:0019693|GO:0008277|GO:0019887|GO:0048878|GO:0007596|GO:0006066|GO:0051280|GO:0043274|GO:0005815|GO:0010644|GO:0032386|GO:0050998|GO:1901652|GO:0031997|GO:0000904|GO:0090257|GO:0071417|GO:0051208|GO:0010038|GO:0031279|GO:0044275|GO:0034767|GO:0051926|GO:0006887|GO:0051347|GO:0036211|GO:0032269|GO:0021762|GO:0042060|GO:0046907|GO:0006811|GO:0008179|GO:0051209|GO:0055082|GO:0046209|GO:0007602|GO:0002429|GO:1901844|GO:0032413|GO:0051279|GO:0032465|GO:0043292|GO:0031981|GO:0022400|GO:0043434|GO:2000272|GO:0007599|GO:0044344|GO:0010564|GO:0071478|GO:0005977|GO:0005996|GO:0034766|GO:0051247|GO:0070848|GO:0034765|GO:0005654|GO:0001664|GO:0034702|GO:0005876|GO:0016052|GO:0002764|GO:0016301|GO:0051353|GO:0010649|GO:0043269|GO:0051341|GO:0019900|GO:0006112|GO:0032270|GO:0014070|GO:0006796|GO:0035556|GO:1901137|GO:0044267|GO:0014075|GO:0051174|GO:0051281|GO:0019211|GO:0032990|GO:0019209|GO:0007399|GO:0046903|GO:0071310|GO:0019888|GO:0031432|GO:0097485|GO:0032414|GO:1902532|GO:0031281|GO:0031328|GO:0051246|GO:0010522|GO:0030154|GO:0048858|GO:1902531|GO:0051928|GO:0008015|GO:0032870|GO:0005856|GO:0000910|GO:0000922|GO:0005634|GO:0060314|GO:0009416|GO:0005819|GO:0045089|GO:0048545|GO:0097305|GO:0035254|GO:0022898|GO:0086065|GO:0045088|GO:2000273|GO:0034220|GO:0048666|GO:0006941|GO:0030182|GO:0008016|GO:0050850|GO:0060315|GO:0007411|GO:0019318|GO:0051343|GO:0016311|GO:0098655|GO:0030016|GO:0045055|GO:0031401|GO:0090281|GO:0008543|GO:0006937|GO:0009259|GO:1901653|GO:0043408|GO:0051412|GO:2001258|GO:0009117|GO:0010922|GO:0032770|GO:0005980|GO:0046390|GO:0090280|GO:0060047|GO:0016056|GO:0034703|GO:0006812|GO:0051592|GO:1901021|GO:0010880|GO:0071363|GO:0016310|GO:1903170|GO:0002768|GO:0038179|GO:0014808|GO:0060402|GO:0005509|GO:0035256|GO:0061564|GO:0016482|GO:0032412|GO:0007167|GO:0015630|GO:0045761|GO:0009584|GO:0030295|GO:0071375|GO:2001259|GO:0043410|GO:0071482|GO:1901020|GO:0001975|GO:0006163|GO:0045762|GO:0050801|GO:0050849|GO:0032868|GO:0007603|GO:1904427|GO:0019901|GO:0072542|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0019932|GO:0048812|GO:0009165|GO:0050848|GO:0031960|GO:0000272|GO:0060316|GO:0060193|GO:0043549|GO:0006873|GO:0090279|GO:0086064|GO:0010921|GO:0033674|GO:0070296|GO:0051000|GO:0048011|GO:0006470|GO:0051384|GO:0035304|GO:0000186|GO:1903169|GO:0007265|GO:0010881|GO:0006164|GO:0002223|GO:0030801|GO:0045859|GO:0045860|GO:0007409|GO:0010517|GO:0006468|GO:0048699|GO:0035307|GO:0006006|GO:0043666|GO:0043539|GO:0006942|GO:0032516|GO:0043405|GO:0060048|GO:0042325|GO:0031800|GO:0001932|GO:0007190|GO:0032869|GO:0018193|GO:0051385|GO:0042326|GO:0038093|GO:0034704|GO:0050999|GO:0055117|GO:1901019|GO:0009187|GO:0030001|GO:0001934|GO:0019722|GO:0035306|GO:0051924|GO:0010518|GO:0001933|GO:0002576|GO:2001257|GO:0030003|GO:0042327|GO:0035303|GO:0030802|GO:0007268|GO:0007169|GO:0009190|GO:0048010|GO:0010863|GO:1901385|GO:0070588|GO:0046058|GO:0010882|GO:0055065|GO:0030819|GO:0046777|GO:0038095|GO:0009152|GO:0031952|GO:0071902|GO:0030817|GO:0097553|GO:0052652|GO:0006875|GO:0030814|GO:0010801|GO:0071900|GO:0018107|GO:0030816|GO:0031954|GO:0032147|GO:0008286|GO:0038127|GO:0010800|GO:0006171|GO:0007173|GO:1901841|GO:0006874|GO:0006816|GO:0007202|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|detection of stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|site of polarized growth|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|sarcomere|protein N-terminus binding|regulation of cellular localization|cellular carbohydrate metabolic process|immune response-activating signal transduction|regulation of cell cycle|cell cycle|regulation of sequestering of calcium ion|coagulation|chemotaxis|innate immune response|cellular aromatic compound metabolic process|cell development|response to radiation|ion channel binding|transport|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|phosphatase regulator activity|positive regulation of calcium ion transport into cytosol|animal organ development|neural nucleus development|inositol phosphate metabolic process|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|enzyme activator activity|microtubule|small molecule metabolic process|secretion by cell|defense response|reactive nitrogen species metabolic process|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|growth cone|brain development|detection of abiotic stimulus|intracellular membrane-bounded organelle|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|muscle system process|activation of innate immune response|cell-cell signaling|response to wounding|head development|carbohydrate metabolic process|movement of cell or subcellular component|homeostatic process|reactive oxygen species metabolic process|cell activation|neuron projection|regulation of signal transduction|calcium-dependent protein binding|cellular homeostasis|midbrain development|protein domain specific binding|negative regulation of intracellular transport|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|nucleobase-containing small molecule metabolic process|nitric-oxide synthase regulator activity|transmembrane transporter complex|cell communication|negative regulation of molecular function|transmembrane transport|membrane organization|detection of chemical stimulus|signal transduction|positive regulation of immune response|negative regulation of calcium ion transport into cytosol|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|regulation of ion homeostasis|response to hormone|regulation of catalytic activity|cell projection organization|generation of precursor metabolites and energy|negative regulation of transporter activity|sequestering of metal ion|phosphatidylinositol 3-kinase binding|regulation of heart rate|cell division|kinase regulator activity|cellular developmental process|integral component of membrane|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|regulation of cardiac conduction|regulation of receptor activity|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|positive regulation of transporter activity|circulatory system process|negative regulation of transmembrane transport|negative regulation of ion transport|oxidation-reduction process|positive regulation of sequestering of calcium ion|response to fibroblast growth factor|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|centrosome|polysaccharide metabolic process|G-protein coupled receptor signaling pathway|muscle contraction|platelet activation|detection of calcium ion|metal ion binding|cell surface receptor signaling pathway|response to lipid|positive regulation of lyase activity|macromolecule modification|detection of light stimulus|innate immune response-activating signal transduction|thioesterase binding|cardiac conduction|central nervous system development|positive regulation of hydrolase activity|ribose phosphate metabolic process|regulation of G-protein coupled receptor protein signaling pathway|protein kinase regulator activity|chemical homeostasis|blood coagulation|alcohol metabolic process|negative regulation of release of sequestered calcium ion into cytosol|phospholipase binding|microtubule organizing center|cell communication by electrical coupling|regulation of intracellular transport|nitric-oxide synthase binding|response to peptide|N-terminal myristoylation domain binding|cell morphogenesis involved in differentiation|regulation of muscle system process|cellular response to organonitrogen compound|sequestering of calcium ion|response to metal ion|regulation of cyclase activity|cellular carbohydrate catabolic process|positive regulation of ion transmembrane transport|negative regulation of calcium ion transport|exocytosis|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|substantia nigra development|wound healing|intracellular transport|ion transport|adenylate cyclase binding|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|nitric oxide metabolic process|phototransduction|immune response-activating cell surface receptor signaling pathway|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol|regulation of cytokinesis|contractile fiber|nuclear lumen|regulation of rhodopsin mediated signaling pathway|response to peptide hormone|negative regulation of receptor activity|hemostasis|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|cellular response to radiation|glycogen metabolic process|monosaccharide metabolic process|negative regulation of ion transmembrane transport|positive regulation of protein metabolic process|response to growth factor|regulation of ion transmembrane transport|nucleoplasm|G-protein coupled receptor binding|ion channel complex|spindle microtubule|carbohydrate catabolic process|immune response-regulating signaling pathway|kinase activity|positive regulation of oxidoreductase activity|regulation of cell communication by electrical coupling|regulation of ion transport|regulation of oxidoreductase activity|kinase binding|energy reserve metabolic process|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|cellular protein metabolic process|response to amine|regulation of phosphorus metabolic process|positive regulation of release of sequestered calcium ion into cytosol|phosphatase activator activity|cell part morphogenesis|kinase activator activity|nervous system development|secretion|cellular response to organic substance|protein phosphatase regulator activity|titin binding|neuron projection guidance|positive regulation of ion transmembrane transporter activity|negative regulation of intracellular signal transduction|positive regulation of cyclase activity|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|regulation of calcium ion transport into cytosol|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|positive regulation of calcium ion transport|blood circulation|cellular response to hormone stimulus|cytoskeleton|cytokinesis|spindle pole|nucleus|regulation of ryanodine-sensitive calcium-release channel activity|response to light stimulus|spindle|positive regulation of innate immune response|response to steroid hormone|response to alcohol|glutamate receptor binding|regulation of transmembrane transporter activity|cell communication involved in cardiac conduction|regulation of innate immune response|positive regulation of receptor activity|ion transmembrane transport|neuron development|striated muscle contraction|neuron differentiation|regulation of heart contraction|positive regulation of calcium-mediated signaling|negative regulation of ryanodine-sensitive calcium-release channel activity|axon guidance|hexose metabolic process|positive regulation of cyclic-nucleotide phosphodiesterase activity|dephosphorylation|cation transmembrane transport|myofibril|regulated exocytosis|positive regulation of protein modification process|negative regulation of calcium ion import|fibroblast growth factor receptor signaling pathway|regulation of muscle contraction|ribonucleotide metabolic process|cellular response to peptide|regulation of MAPK cascade|response to corticosterone|negative regulation of cation channel activity|nucleotide metabolic process|positive regulation of phosphatase activity|positive regulation of monooxygenase activity|glycogen catabolic process|ribose phosphate biosynthetic process|positive regulation of calcium ion import|heart contraction|rhodopsin mediated signaling pathway|cation channel complex|cation transport|response to calcium ion|positive regulation of calcium ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|cellular response to growth factor stimulus|phosphorylation|negative regulation of calcium ion transmembrane transport|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|calcium ion transport into cytosol|calcium ion binding|G-protein coupled glutamate receptor binding|axon development|cytosolic transport|regulation of ion transmembrane transporter activity|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|regulation of adenylate cyclase activity|detection of visible light|protein kinase activator activity|cellular response to peptide hormone stimulus|positive regulation of cation channel activity|positive regulation of MAPK cascade|cellular response to light stimulus|negative regulation of calcium ion transmembrane transporter activity|response to amphetamine|purine nucleotide metabolic process|positive regulation of adenylate cyclase activity|ion homeostasis|negative regulation of calcium-mediated signaling|response to insulin|phototransduction, visible light|positive regulation of calcium ion transmembrane transport|protein kinase binding|protein phosphatase activator activity|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|second-messenger-mediated signaling|neuron projection morphogenesis|nucleotide biosynthetic process|regulation of calcium-mediated signaling|response to corticosteroid|polysaccharide catabolic process|positive regulation of ryanodine-sensitive calcium-release channel activity|positive regulation of lipase activity|regulation of kinase activity|cellular ion homeostasis|regulation of calcium ion import|cell communication by electrical coupling involved in cardiac conduction|regulation of phosphatase activity|positive regulation of kinase activity|sarcoplasmic reticulum calcium ion transport|positive regulation of nitric-oxide synthase activity|neurotrophin TRK receptor signaling pathway|protein dephosphorylation|response to glucocorticoid|regulation of protein dephosphorylation|activation of MAPKK activity|regulation of calcium ion transmembrane transport|Ras protein signal transduction|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|purine nucleotide biosynthetic process|stimulatory C-type lectin receptor signaling pathway|positive regulation of cyclic nucleotide metabolic process|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|regulation of phospholipase activity|protein phosphorylation|generation of neurons|positive regulation of protein dephosphorylation|glucose metabolic process|regulation of phosphoprotein phosphatase activity|protein serine/threonine kinase activator activity|regulation of striated muscle contraction|positive regulation of phosphoprotein phosphatase activity|regulation of MAP kinase activity|cardiac muscle contraction|regulation of phosphorylation|type 3 metabotropic glutamate receptor binding|regulation of protein phosphorylation|activation of adenylate cyclase activity|cellular response to insulin stimulus|peptidyl-amino acid modification|response to mineralocorticoid|negative regulation of phosphorylation|Fc receptor signaling pathway|calcium channel complex|regulation of nitric-oxide synthase activity|regulation of cardiac muscle contraction|regulation of calcium ion transmembrane transporter activity|cyclic nucleotide metabolic process|metal ion transport|positive regulation of protein phosphorylation|calcium-mediated signaling|positive regulation of dephosphorylation|regulation of calcium ion transport|positive regulation of phospholipase activity|negative regulation of protein phosphorylation|platelet degranulation|regulation of cation channel activity|cellular cation homeostasis|positive regulation of phosphorylation|regulation of dephosphorylation|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|cyclic nucleotide biosynthetic process|vascular endothelial growth factor receptor signaling pathway|positive regulation of phospholipase C activity|regulation of voltage-gated calcium channel activity|calcium ion transmembrane transport|cAMP metabolic process|regulation of cardiac muscle contraction by calcium ion signaling|metal ion homeostasis|positive regulation of cAMP biosynthetic process|protein autophosphorylation|Fc-epsilon receptor signaling pathway|purine ribonucleotide biosynthetic process|regulation of protein autophosphorylation|positive regulation of protein serine/threonine kinase activity|regulation of cAMP biosynthetic process|calcium ion transmembrane import into cytosol|cyclic purine nucleotide metabolic process|cellular metal ion homeostasis|regulation of cAMP metabolic process|negative regulation of peptidyl-threonine phosphorylation|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|positive regulation of cAMP metabolic process|positive regulation of protein autophosphorylation|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|positive regulation of peptidyl-threonine phosphorylation|cAMP biosynthetic process|epidermal growth factor receptor signaling pathway|regulation of high voltage-gated calcium channel activity|cellular calcium ion homeostasis|calcium ion transport|activation of phospholipase C activity|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K02183 calmodulin[-] hsa04740|hsa04014|hsa04015|hsa04024|hsa04020|hsa05034|hsa05152|hsa05010|hsa04022|hsa04921|hsa04261|hsa04910|hsa04728|hsa04114|hsa04722|hsa04270|hsa04922|hsa04916|hsa04915|hsa04750|hsa04070|hsa04713|hsa04912|hsa04970|hsa04925|hsa05133|hsa04971|hsa05031|hsa04720|hsa05214|hsa04924|hsa04744 Olfactory transduction - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Glioma - Homo sapiens (human)|Renin secretion - Homo sapiens (human)|Phototransduction - Homo sapiens (human) 14:90396502-90408261 861 1206 1203 3437 3642 2985 4.39108967474393 5.58980591247219 5.53158092830649 15.7053099404767 15.2397277825801 14.2673231325616 5.1708255051742 15.0707869518728 -1.54328822663896 2.00113923316435e-13 7.78904963062432e-12 DOWN ENSG00000139697 SBNO1 strawberry notch homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:22973] GO:0009987|GO:0008152|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cellular process|metabolic process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 12:123289109-123364843 3634 4244 3847 1556 1501 1647 21.9557306734227 23.3033545541053 20.9555681212483 8.42306734789959 7.44066451070663 9.3257860340519 22.0715511162588 8.39650596421937 1.39432701147904 2.00572503183008e-13 7.79673373701241e-12 UP ENSG00000123358 NR4A1 nuclear receptor subfamily 4 group A member 1 [Source:HGNC Symbol;Acc:HGNC:7980] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0038023|GO:0048870|GO:0009653|GO:0043227|GO:0009605|GO:0004879|GO:0009893|GO:0009058|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0042802|GO:0098531|GO:0048514|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006935|GO:0045087|GO:0006725|GO:0003707|GO:0009888|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0010942|GO:0061061|GO:0045786|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0000981|GO:0005635|GO:0006928|GO:0005667|GO:0046983|GO:0050673|GO:0060548|GO:0006139|GO:0050776|GO:0001525|GO:0007154|GO:0044092|GO:0016477|GO:0007165|GO:0008134|GO:0009725|GO:0008219|GO:0031965|GO:0050790|GO:0043086|GO:0048869|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0071774|GO:0050679|GO:0000982|GO:0032268|GO:0003677|GO:0002040|GO:0010468|GO:0090132|GO:0034645|GO:0046872|GO:0007166|GO:0033993|GO:0001944|GO:0072358|GO:0051427|GO:0043069|GO:0046982|GO:0051252|GO:1901652|GO:0071417|GO:0010628|GO:0001935|GO:0001667|GO:0032269|GO:0060537|GO:0031981|GO:0060326|GO:0043434|GO:0044344|GO:0051346|GO:0070848|GO:0006508|GO:0005654|GO:0050678|GO:0002764|GO:0044342|GO:0012501|GO:0014070|GO:0035556|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0009755|GO:0001228|GO:0043068|GO:0007517|GO:0016070|GO:0072359|GO:0032870|GO:0010557|GO:0005634|GO:0042803|GO:0043067|GO:0048545|GO:0030522|GO:0043401|GO:0060538|GO:0010466|GO:0045893|GO:0045444|GO:0008543|GO:0043065|GO:1901653|GO:0032774|GO:0043565|GO:0030162|GO:2001141|GO:0035257|GO:0001077|GO:0071363|GO:0002768|GO:0038179|GO:0052547|GO:0071383|GO:0071407|GO:0002042|GO:0035767|GO:0001936|GO:0048017|GO:0007167|GO:0071375|GO:0035914|GO:0010631|GO:0042981|GO:0045861|GO:0046914|GO:0043066|GO:0001938|GO:0014706|GO:0061469|GO:0071396|GO:0006351|GO:0006915|GO:0006355|GO:0048011|GO:0045944|GO:0006366|GO:0048015|GO:0035258|GO:0006352|GO:0006357|GO:0043281|GO:0007519|GO:1903506|GO:0035924|GO:0010951|GO:0038093|GO:0071376|GO:0043154|GO:0043542|GO:0008270|GO:0007169|GO:0052548|GO:0006367|GO:2000117|GO:0038095|GO:0035259|GO:2000116|GO:0038127|GO:0043534|GO:0007173 locomotion|developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|signaling receptor activity|cell motility|anatomical structure morphogenesis|membrane-bounded organelle|response to external stimulus|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|positive regulation of metabolic process|biosynthetic process|intracellular|regulation of immune system process|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|identical protein binding|transcription factor activity, direct ligand regulated sequence-specific DNA binding|blood vessel morphogenesis|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|chemotaxis|innate immune response|cellular aromatic compound metabolic process|steroid hormone receptor activity|tissue development|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell death|muscle structure development|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nuclear envelope|movement of cell or subcellular component|transcription factor complex|protein dimerization activity|epithelial cell proliferation|negative regulation of cell death|nucleobase-containing compound metabolic process|regulation of immune response|angiogenesis|cell communication|negative regulation of molecular function|cell migration|signal transduction|transcription factor binding|response to hormone|cell death|nuclear membrane|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|positive regulation of epithelial cell proliferation|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of cellular protein metabolic process|DNA binding|sprouting angiogenesis|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|response to lipid|vasculature development|cardiovascular system development|hormone receptor binding|negative regulation of programmed cell death|protein heterodimerization activity|regulation of RNA metabolic process|response to peptide|cellular response to organonitrogen compound|positive regulation of gene expression|endothelial cell proliferation|ameboidal-type cell migration|negative regulation of cellular protein metabolic process|muscle tissue development|nuclear lumen|cell chemotaxis|response to peptide hormone|cellular response to fibroblast growth factor stimulus|negative regulation of hydrolase activity|response to growth factor|proteolysis|nucleoplasm|regulation of epithelial cell proliferation|immune response-regulating signaling pathway|type B pancreatic cell proliferation|programmed cell death|response to organic cyclic compound|intracellular signal transduction|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of programmed cell death|muscle organ development|RNA metabolic process|circulatory system development|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|regulation of programmed cell death|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|skeletal muscle organ development|negative regulation of peptidase activity|positive regulation of transcription, DNA-templated|fat cell differentiation|fibroblast growth factor receptor signaling pathway|positive regulation of apoptotic process|cellular response to peptide|RNA biosynthetic process|sequence-specific DNA binding|regulation of proteolysis|regulation of RNA biosynthetic process|nuclear hormone receptor binding|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cellular response to growth factor stimulus|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|regulation of peptidase activity|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|cell migration involved in sprouting angiogenesis|endothelial cell chemotaxis|regulation of endothelial cell proliferation|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|skeletal muscle cell differentiation|epithelial cell migration|regulation of apoptotic process|negative regulation of proteolysis|transition metal ion binding|negative regulation of apoptotic process|positive regulation of endothelial cell proliferation|striated muscle tissue development|regulation of type B pancreatic cell proliferation|cellular response to lipid|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|neurotrophin TRK receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|phosphatidylinositol-mediated signaling|steroid hormone receptor binding|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of cysteine-type endopeptidase activity involved in apoptotic process|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|cellular response to vascular endothelial growth factor stimulus|negative regulation of endopeptidase activity|Fc receptor signaling pathway|cellular response to corticotropin-releasing hormone stimulus|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|endothelial cell migration|zinc ion binding|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|transcription initiation from RNA polymerase II promoter|negative regulation of cysteine-type endopeptidase activity|Fc-epsilon receptor signaling pathway|glucocorticoid receptor binding|regulation of cysteine-type endopeptidase activity|ERBB signaling pathway|blood vessel endothelial cell migration|epidermal growth factor receptor signaling pathway K04465 nuclear receptor subfamily 4 group A member 1[-] hsa04151|hsa04010|hsa04925 PI3K-Akt signaling pathway - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human) 12:52022832-52059507 352 399 805 100 138 131 1.16504494637307 1.20019951123931 2.40220991317876 0.296551230865026 0.374753795887359 0.406348979774336 1.58915145693038 0.359218002175574 2.14532507235163 2.05018635820138e-13 7.95920202051287e-12 UP ENSG00000120675 DNAJC15 DnaJ heat shock protein family (Hsp40) member C15 [Source:HGNC Symbol;Acc:HGNC:20325] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009605|GO:0031224|GO:0005622|GO:0005515|GO:0031090|GO:0019222|GO:0006725|GO:0019866|GO:0006810|GO:1901360|GO:0009991|GO:0034641|GO:0015980|GO:0044281|GO:0019637|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0043231|GO:0005737|GO:0031668|GO:0031966|GO:0045184|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0006629|GO:0006091|GO:0016021|GO:0022900|GO:0043254|GO:0031324|GO:0031323|GO:0042594|GO:0055114|GO:0005740|GO:0031333|GO:1901856|GO:0019693|GO:0015031|GO:0009116|GO:0022904|GO:0005743|GO:0005739|GO:0009267|GO:0006461|GO:0043467|GO:0006796|GO:0051174|GO:0019216|GO:0006119|GO:0045333|GO:0031669|GO:0031667|GO:0002082|GO:0009259|GO:0009117|GO:0045980|GO:0042773|GO:0016310|GO:0043457|GO:1902957|GO:0006163|GO:0090324|GO:0006120|GO:0042278|GO:1903578|GO:0042775|GO:0042325|GO:1903579|GO:0042326|GO:0046034 cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|response to external stimulus|intrinsic component of membrane|intracellular|protein binding|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organelle inner membrane|transport|organic cyclic compound metabolic process|response to extracellular stimulus|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cellular response to extracellular stimulus|mitochondrial membrane|establishment of protein localization|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|lipid metabolic process|generation of precursor metabolites and energy|integral component of membrane|electron transport chain|regulation of protein complex assembly|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to starvation|oxidation-reduction process|mitochondrial envelope|negative regulation of protein complex assembly|negative regulation of cellular respiration|ribose phosphate metabolic process|protein transport|nucleoside metabolic process|respiratory electron transport chain|mitochondrial inner membrane|mitochondrion|cellular response to starvation|protein complex assembly|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|regulation of lipid metabolic process|oxidative phosphorylation|cellular respiration|cellular response to nutrient levels|response to nutrient levels|regulation of oxidative phosphorylation|ribonucleotide metabolic process|nucleotide metabolic process|negative regulation of nucleotide metabolic process|ATP synthesis coupled electron transport|phosphorylation|regulation of cellular respiration|negative regulation of mitochondrial electron transport, NADH to ubiquinone|purine nucleotide metabolic process|negative regulation of oxidative phosphorylation|mitochondrial electron transport, NADH to ubiquinone|purine nucleoside metabolic process|regulation of ATP metabolic process|mitochondrial ATP synthesis coupled electron transport|regulation of phosphorylation|negative regulation of ATP metabolic process|negative regulation of phosphorylation|ATP metabolic process - - - - 13:43023203-43114224 145 145 151 624 595 454 1.2633161207785 1.14813267965549 1.18613773029507 4.87108086515727 4.2533173082909 3.70704967434483 1.19919551024302 4.27714928259767 -1.83458267455694 2.14659710357493e-13 8.3226636272891e-12 DOWN ENSG00000110497 AMBRA1 autophagy/beclin-1 regulator 1 [Source:HGNC Symbol;Acc:HGNC:25990] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0019867|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0031090|GO:0019222|GO:0042127|GO:0044255|GO:0010506|GO:0009888|GO:1902115|GO:0035295|GO:0051130|GO:0010941|GO:0005930|GO:0009991|GO:0007275|GO:0031982|GO:0019637|GO:0031325|GO:0051128|GO:0033554|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0010508|GO:0021915|GO:0031966|GO:0060548|GO:0010646|GO:0043085|GO:0007154|GO:0006629|GO:0000422|GO:0008219|GO:0008285|GO:0016236|GO:0050790|GO:0048869|GO:0031323|GO:0006996|GO:0005740|GO:0005829|GO:1901215|GO:1903008|GO:0000423|GO:0031410|GO:0007005|GO:0043069|GO:0005741|GO:0070997|GO:2000785|GO:1903146|GO:0005773|GO:0009790|GO:0016023|GO:0090218|GO:0051347|GO:0016239|GO:0016241|GO:0048471|GO:0031988|GO:0005739|GO:1901214|GO:0070925|GO:1903599|GO:0012501|GO:0060429|GO:0006796|GO:0033043|GO:0051174|GO:0007399|GO:0019216|GO:0030154|GO:0000045|GO:0031667|GO:0043067|GO:0006644|GO:0007033|GO:0044389|GO:0010638|GO:0031625|GO:0009792|GO:0030139|GO:0043523|GO:0043552|GO:0043550|GO:0016310|GO:0010822|GO:0044088|GO:0005776|GO:0010821|GO:0042981|GO:1903725|GO:0043066|GO:0051402|GO:0043524|GO:0098779|GO:0043549|GO:0006915|GO:0033674|GO:0043551|GO:0045335|GO:0042325|GO:0043009|GO:0061734|GO:0042327 developmental process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|outer membrane|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|anatomical structure development|cilium|organelle membrane|regulation of metabolic process|regulation of cell proliferation|cellular lipid metabolic process|regulation of autophagy|tissue development|regulation of organelle assembly|tube development|positive regulation of cellular component organization|regulation of cell death|axoneme|response to extracellular stimulus|multicellular organism development|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|positive regulation of autophagy|neural tube development|mitochondrial membrane|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|cell communication|lipid metabolic process|mitophagy|cell death|negative regulation of cell proliferation|macroautophagy|regulation of catalytic activity|cellular developmental process|regulation of cellular metabolic process|organelle organization|mitochondrial envelope|cytosol|negative regulation of neuron death|organelle disassembly|macromitophagy|cytoplasmic vesicle|mitochondrion organization|negative regulation of programmed cell death|mitochondrial outer membrane|neuron death|regulation of autophagosome assembly|regulation of mitophagy|vacuole|embryo development|cytoplasmic, membrane-bounded vesicle|positive regulation of lipid kinase activity|positive regulation of transferase activity|positive regulation of macroautophagy|regulation of macroautophagy|perinuclear region of cytoplasm|membrane-bounded vesicle|mitochondrion|regulation of neuron death|organelle assembly|positive regulation of mitophagy|programmed cell death|epithelium development|phosphate-containing compound metabolic process|regulation of organelle organization|regulation of phosphorus metabolic process|nervous system development|regulation of lipid metabolic process|cell differentiation|autophagosome assembly|response to nutrient levels|regulation of programmed cell death|phospholipid metabolic process|vacuole organization|ubiquitin-like protein ligase binding|positive regulation of organelle organization|ubiquitin protein ligase binding|embryo development ending in birth or egg hatching|endocytic vesicle|regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase activity|regulation of lipid kinase activity|phosphorylation|positive regulation of mitochondrion organization|regulation of vacuole organization|autophagosome|regulation of mitochondrion organization|regulation of apoptotic process|regulation of phospholipid metabolic process|negative regulation of apoptotic process|neuron apoptotic process|negative regulation of neuron apoptotic process|mitophagy in response to mitochondrial depolarization|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of phosphatidylinositol 3-kinase activity|phagocytic vesicle|regulation of phosphorylation|chordate embryonic development|parkin-mediated mitophagy in response to mitochondrial depolarization|positive regulation of phosphorylation - - - - 11:46396414-46594125 152 189 279 689 767 728 0.812762238696218 0.918461752029783 1.34504820037673 3.30092711363959 3.36497523552056 3.64820372481014 1.02542406370091 3.4380353579901 -1.74536372301178 2.26651937338409e-13 8.77622170856143e-12 DOWN ENSG00000148840 PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 [Source:HGNC Symbol;Acc:HGNC:30025] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0001076|GO:0006139|GO:0008134|GO:0000166|GO:0044249|GO:0031323|GO:0006996|GO:0051090|GO:0003713|GO:0010468|GO:0034645|GO:0003723|GO:0001104|GO:0007005|GO:0051252|GO:0010628|GO:0051091|GO:0031981|GO:0005654|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0030374|GO:0044822|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506 cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor activity, RNA polymerase II transcription factor binding|nucleobase-containing compound metabolic process|transcription factor binding|nucleotide binding|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|RNA polymerase II transcription cofactor activity|mitochondrion organization|regulation of RNA metabolic process|positive regulation of gene expression|positive regulation of sequence-specific DNA binding transcription factor activity|nuclear lumen|nucleoplasm|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|ligand-dependent nuclear receptor transcription coactivator activity|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 10:102132994-102150331 2977 3080 2280 1045 981 706 25.6934590515678 24.1587522938991 17.7416000361571 8.08086614151131 6.94673510610676 5.71054040104347 22.5312704605413 6.91271388288718 1.704604545589 2.28625566914806e-13 8.84117574439719e-12 UP ENSG00000173227 SYT12 synaptotagmin 12 [Source:HGNC Symbol;Acc:HGNC:18381] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0030672|GO:0008021|GO:0050794|GO:0043229|GO:0016079|GO:0043167|GO:0051641|GO:0023051|GO:0043227|GO:0008289|GO:0031224|GO:0005622|GO:0007269|GO:0005515|GO:0012505|GO:0031090|GO:0060341|GO:0050804|GO:0051640|GO:0006810|GO:0043168|GO:0032940|GO:0005543|GO:0031982|GO:0030276|GO:0050806|GO:0050803|GO:0043231|GO:0043169|GO:0030133|GO:0005737|GO:0007267|GO:0012506|GO:0051656|GO:0030658|GO:0010646|GO:0000149|GO:0007154|GO:0051649|GO:0001505|GO:0016021|GO:0048792|GO:0046928|GO:0016192|GO:0006836|GO:0051650|GO:0048167|GO:0046872|GO:0031410|GO:0048489|GO:0016023|GO:0006887|GO:0070382|GO:0046907|GO:0051046|GO:0031988|GO:0005544|GO:0060291|GO:0030659|GO:0046903|GO:0051648|GO:0019905|GO:0045055|GO:0005509|GO:0016482|GO:0036465|GO:0006897|GO:0048488|GO:0017156|GO:0006898|GO:0007268|GO:0072583 synapse|signaling|cell|membrane|cellular process|cell junction|binding|synaptic vesicle membrane|synaptic vesicle|regulation of cellular process|intracellular organelle|synaptic vesicle exocytosis|ion binding|cellular localization|regulation of signaling|membrane-bounded organelle|lipid binding|intrinsic component of membrane|intracellular|neurotransmitter secretion|protein binding|endomembrane system|organelle membrane|regulation of cellular localization|modulation of synaptic transmission|organelle localization|transport|anion binding|secretion by cell|phospholipid binding|vesicle|clathrin binding|positive regulation of synaptic transmission|regulation of synapse structure or activity|intracellular membrane-bounded organelle|cation binding|transport vesicle|cytoplasm|cell-cell signaling|vesicle membrane|establishment of organelle localization|transport vesicle membrane|regulation of cell communication|SNARE binding|cell communication|establishment of localization in cell|regulation of neurotransmitter levels|integral component of membrane|spontaneous exocytosis of neurotransmitter|regulation of neurotransmitter secretion|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|regulation of synaptic plasticity|metal ion binding|cytoplasmic vesicle|synaptic vesicle transport|cytoplasmic, membrane-bounded vesicle|exocytosis|exocytic vesicle|intracellular transport|regulation of secretion|membrane-bounded vesicle|calcium-dependent phospholipid binding|long-term synaptic potentiation|cytoplasmic vesicle membrane|secretion|vesicle localization|syntaxin binding|regulated exocytosis|calcium ion binding|cytosolic transport|synaptic vesicle recycling|endocytosis|synaptic vesicle endocytosis|calcium ion regulated exocytosis|receptor-mediated endocytosis|synaptic transmission|clathrin-mediated endocytosis - - - - 11:67006778-67050863 44 51 98 298 310 379 0.243005097721507 0.255987104207559 0.487985290363089 1.47461374880671 1.40473237745098 1.96170133915703 0.328992497430718 1.61368248847157 -2.29423014961056 2.34138171381348e-13 9.0426403213697e-12 DOWN ENSG00000165525 NEMF nuclear export mediator factor [Source:HGNC Symbol;Acc:HGNC:10663] GO:0005623|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0006810|GO:0043231|GO:0051649|GO:0046907|GO:0005634|GO:0051169|GO:0006913|GO:0051168 cell|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|transport|intracellular membrane-bounded organelle|establishment of localization in cell|intracellular transport|nucleus|nuclear transport|nucleocytoplasmic transport|nuclear export - - - - 14:49782083-49853203 467 493 529 1663 1772 1299 2.10663420885735 2.02115109684581 2.1515010779597 6.72143353895782 6.55848699501865 5.49173983218336 2.09309546122095 6.25722012205328 -1.57988374627593 2.35461979736731e-13 9.08201801428988e-12 DOWN ENSG00000162642 C1orf52 chromosome 1 open reading frame 52 [Source:HGNC Symbol;Acc:HGNC:24871] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0003723|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|RNA binding|nucleus|poly(A) RNA binding - - - - 1:85249953-85259672 779 827 823 312 315 333 11.684477646979 11.273471181799 11.1297643028082 4.19299932807718 3.87659291467686 4.68106517473405 11.3625710438621 4.2502191391627 1.41868018190856 2.39069100549185e-13 9.20925022941339e-12 UP ENSG00000049618 ARID1B AT-rich interaction domain 1B [Source:HGNC Symbol;Acc:HGNC:18040] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0070603|GO:0043231|GO:0005737|GO:0006139|GO:0071565|GO:0044249|GO:0031323|GO:0006996|GO:0003713|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0006325|GO:0010628|GO:0031981|GO:0005654|GO:0010467|GO:0007399|GO:0090544|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0040029|GO:0045815|GO:0016568|GO:0016514|GO:0006351|GO:0006355|GO:1903506|GO:0048096|GO:0006338 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nBAF complex|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|chromatin organization|positive regulation of gene expression|nuclear lumen|nucleoplasm|gene expression|nervous system development|BAF-type complex|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|chromatin modification|SWI/SNF complex|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|chromatin-mediated maintenance of transcription|chromatin remodeling - - - - 6:156777374-157210779 194 205 194 657 787 609 0.521567930577819 0.500890401386003 0.470244701668265 1.58260201516976 1.73600611803417 1.53445692452051 0.497567677877362 1.61768835257481 -1.70096902375833 2.49703031683473e-13 9.60648751015259e-12 DOWN ENSG00000139173 TMEM117 transmembrane protein 117 [Source:HGNC Symbol;Acc:HGNC:25308] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0043231|GO:0005737|GO:0005783|GO:0016021 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane - - - - 12:43835967-44389762 5 7 8 51 80 55 0.0453346507581741 0.0576828427597227 0.0653966182996293 0.414294707207191 0.595114340026207 0.467333901086504 0.0561380372725087 0.492247649439967 -3.13233378746288 2.57279717341303e-13 9.88523639833625e-12 DOWN ENSG00000129295 LRRC6 leucine rich repeat containing 6 [Source:HGNC Symbol;Acc:HGNC:16725] GO:0040011|GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0042995|GO:0044702|GO:0003006|GO:0048870|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0045137|GO:0007275|GO:0048513|GO:0022607|GO:0048608|GO:0005737|GO:0007389|GO:0030317|GO:0006928|GO:0007548|GO:0008406|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0008584|GO:0070286|GO:0046661|GO:0007010|GO:0061458|GO:0035082|GO:0044782|GO:0030031|GO:0007018|GO:0006461|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0000226|GO:0046546|GO:0060271|GO:0036159|GO:0034622|GO:0036158|GO:0043623|GO:0009855|GO:0001578|GO:0044458|GO:0003341|GO:0003351|GO:0007368|GO:0060287 locomotion|developmental process|reproduction|cell|cellular process|reproductive process|binding|cell projection|single organism reproductive process|developmental process involved in reproduction|cell motility|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|development of primary sexual characteristics|multicellular organism development|animal organ development|cellular component assembly|reproductive structure development|cytoplasm|pattern specification process|sperm motility|movement of cell or subcellular component|sex differentiation|gonad development|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|male gonad development|axonemal dynein complex assembly|male sex differentiation|cytoskeleton organization|reproductive system development|axoneme assembly|cilium organization|cell projection assembly|microtubule-based movement|protein complex assembly|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|microtubule cytoskeleton organization|development of primary male sexual characteristics|cilium morphogenesis|inner dynein arm assembly|cellular macromolecular complex assembly|outer dynein arm assembly|cellular protein complex assembly|determination of bilateral symmetry|microtubule bundle formation|motile cilium assembly|cilium movement|epithelial cilium movement|determination of left/right symmetry|epithelial cilium movement involved in determination of left/right asymmetry - - - - 8:132571953-132675617 0 2 1 31 25 37 0 0.0237310085194055 0.0117653521262171 0.362626477204468 0.267800176221954 0.452723264299959 0.0118321202152075 0.36104997257546 -4.93141801232577 2.58735699586759e-13 9.92840048260039e-12 DOWN ENSG00000226979 LTA lymphotoxin alpha [Source:HGNC Symbol;Acc:HGNC:6709] GO:0032502|GO:0040007|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0006955|GO:0009628|GO:0045926|GO:0051707|GO:0071944|GO:0040008|GO:0009607|GO:0009605|GO:0005615|GO:0002684|GO:0050793|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0008284|GO:0042127|GO:0002250|GO:0006959|GO:0045595|GO:0048468|GO:0010941|GO:0009991|GO:0007275|GO:0048513|GO:0005102|GO:0006952|GO:0010942|GO:0098542|GO:0001817|GO:0045597|GO:0002437|GO:0048144|GO:0001816|GO:0007267|GO:0009611|GO:0001819|GO:0014009|GO:0042493|GO:0009617|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0008219|GO:0008285|GO:0001666|GO:0048869|GO:0044146|GO:0010033|GO:0002443|GO:0007584|GO:0005126|GO:0060252|GO:0007166|GO:0033993|GO:0034097|GO:0050727|GO:0002237|GO:0048535|GO:0010720|GO:0002439|GO:0005125|GO:0060251|GO:0006954|GO:0048145|GO:0050769|GO:0050729|GO:0044117|GO:0002863|GO:0002821|GO:0002460|GO:0012501|GO:0002922|GO:0032609|GO:0007399|GO:0071310|GO:0002819|GO:0048147|GO:0042742|GO:0030154|GO:0043068|GO:0032729|GO:0031667|GO:0002455|GO:0032496|GO:0002920|GO:0043067|GO:0051960|GO:0032649|GO:0044130|GO:0019221|GO:0002678|GO:0043065|GO:0002676|GO:0032813|GO:0002876|GO:0002544|GO:0002925|GO:0050830|GO:0014015|GO:0042981|GO:0071345|GO:0034612|GO:0019724|GO:0022008|GO:0050767|GO:0006915|GO:0016064|GO:0005164|GO:0048699|GO:0014013|GO:0071356|GO:0042063|GO:0033209|GO:0002891 developmental process|growth|immune system process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|immune response|response to abiotic stimulus|negative regulation of growth|response to other organism|cell periphery|regulation of growth|response to biotic stimulus|response to external stimulus|extracellular space|positive regulation of immune system process|regulation of developmental process|regulation of immune system process|immune system development|protein binding|plasma membrane|anatomical structure development|positive regulation of cell proliferation|regulation of cell proliferation|adaptive immune response|humoral immune response|regulation of cell differentiation|cell development|regulation of cell death|response to extracellular stimulus|multicellular organism development|animal organ development|receptor binding|defense response|positive regulation of cell death|defense response to other organism|regulation of cytokine production|positive regulation of cell differentiation|inflammatory response to antigenic stimulus|fibroblast proliferation|cytokine production|cell-cell signaling|response to wounding|positive regulation of cytokine production|glial cell proliferation|response to drug|response to bacterium|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|cell death|negative regulation of cell proliferation|response to hypoxia|cellular developmental process|negative regulation of growth of symbiont involved in interaction with host|response to organic substance|leukocyte mediated immunity|response to nutrient|cytokine receptor binding|positive regulation of glial cell proliferation|cell surface receptor signaling pathway|response to lipid|response to cytokine|regulation of inflammatory response|response to molecule of bacterial origin|lymph node development|positive regulation of cell development|chronic inflammatory response to antigenic stimulus|cytokine activity|regulation of glial cell proliferation|inflammatory response|regulation of fibroblast proliferation|positive regulation of neurogenesis|positive regulation of inflammatory response|growth of symbiont in host|positive regulation of inflammatory response to antigenic stimulus|positive regulation of adaptive immune response|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|programmed cell death|positive regulation of humoral immune response|interferon-gamma production|nervous system development|cellular response to organic substance|regulation of adaptive immune response|negative regulation of fibroblast proliferation|defense response to bacterium|cell differentiation|positive regulation of programmed cell death|positive regulation of interferon-gamma production|response to nutrient levels|humoral immune response mediated by circulating immunoglobulin|response to lipopolysaccharide|regulation of humoral immune response|regulation of programmed cell death|regulation of nervous system development|regulation of interferon-gamma production|negative regulation of growth of symbiont in host|cytokine-mediated signaling pathway|positive regulation of chronic inflammatory response|positive regulation of apoptotic process|regulation of chronic inflammatory response|tumor necrosis factor receptor superfamily binding|positive regulation of chronic inflammatory response to antigenic stimulus|chronic inflammatory response|positive regulation of humoral immune response mediated by circulating immunoglobulin|defense response to Gram-positive bacterium|positive regulation of gliogenesis|regulation of apoptotic process|cellular response to cytokine stimulus|response to tumor necrosis factor|B cell mediated immunity|neurogenesis|regulation of neurogenesis|apoptotic process|immunoglobulin mediated immune response|tumor necrosis factor receptor binding|generation of neurons|regulation of gliogenesis|cellular response to tumor necrosis factor|gliogenesis|tumor necrosis factor-mediated signaling pathway|positive regulation of immunoglobulin mediated immune response - - - - 6:31572054-31574324 36 31 23 2 1 0 1.18059378211949 0.923939169730656 0.680047205260798 0.0587675962974823 0.0269185107020642 0 0.928193385703648 0.0285620356665155 5.02225470535804 2.61319204322214e-13 1.00146643463869e-11 UP ENSG00000153936 HS2ST1 heparan sulfate 2-O-sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:5193] GO:0005623|GO:0016020|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0044281|GO:0043231|GO:0005737|GO:0005975|GO:0016021|GO:0005794|GO:1901137|GO:0008146|GO:0000139|GO:0009059|GO:0006024|GO:0030203 cell|membrane|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|integral component of membrane|Golgi apparatus|carbohydrate derivative biosynthetic process|sulfotransferase activity|Golgi membrane|macromolecule biosynthetic process|glycosaminoglycan biosynthetic process|glycosaminoglycan metabolic process K02513 heparan sulfate 2-O-sulfotransferase HS2ST1 [EC:2.8.2.-][-] hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin - Homo sapiens (human) 1:86914648-87109998 338 378 715 1729 1852 1717 2.96197605458512 3.01048823528295 5.64917481187559 13.5755460059495 13.3159884202704 14.1014543748604 3.87387970058122 13.6643296003601 -1.81856362174847 2.68034974654454e-13 1.02588668376078e-11 DOWN ENSG00000054611 TBC1D22A TBC1 domain family member 22A [Source:HGNC Symbol;Acc:HGNC:1309] GO:0008152|GO:0005488|GO:0009893|GO:0030234|GO:0005515|GO:0019222|GO:0042802|GO:0008047|GO:0046983|GO:0043085|GO:0050790|GO:0005096|GO:0051345|GO:0030695|GO:0042803|GO:0043087|GO:0043547 metabolic process|binding|positive regulation of metabolic process|enzyme regulator activity|protein binding|regulation of metabolic process|identical protein binding|enzyme activator activity|protein dimerization activity|positive regulation of catalytic activity|regulation of catalytic activity|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|protein homodimerization activity|regulation of GTPase activity|positive regulation of GTPase activity - - - - 22:46762617-47175699 153 140 306 811 859 796 0.902496004685289 0.750518870169257 1.62738074751204 4.28619981765441 4.15733885889372 4.40044045156783 1.09346520745553 4.28132637603865 -1.96915050335456 2.69503426323308e-13 1.03018633667811e-11 DOWN ENSG00000104205 SGK3 serum/glucocorticoid regulated kinase family member 3 [Source:HGNC Symbol;Acc:HGNC:10812] GO:0040011|GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0016043|GO:0043227|GO:0008289|GO:0040008|GO:0009058|GO:0016247|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0019222|GO:0042127|GO:0006725|GO:0006810|GO:1901360|GO:0010941|GO:0034641|GO:0043168|GO:0005543|GO:0001882|GO:0043270|GO:0016772|GO:0031982|GO:0046483|GO:0051128|GO:0043231|GO:0005737|GO:0005246|GO:0006928|GO:0042592|GO:0015459|GO:0019725|GO:0006139|GO:0007154|GO:0055085|GO:0051270|GO:0016477|GO:0007165|GO:0008219|GO:0017080|GO:0000166|GO:0017081|GO:2000145|GO:0044249|GO:0019538|GO:0001558|GO:0031323|GO:0032411|GO:0005768|GO:0051090|GO:0005829|GO:0010468|GO:0034645|GO:0035639|GO:0043412|GO:0031410|GO:0005769|GO:0048878|GO:0035091|GO:0051252|GO:0001883|GO:0030334|GO:0016023|GO:0036211|GO:0006811|GO:0032549|GO:0055082|GO:0055037|GO:0031988|GO:0016301|GO:0043269|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0010467|GO:0010765|GO:0017076|GO:0009059|GO:0016070|GO:0016773|GO:0043067|GO:0034220|GO:0032774|GO:0005524|GO:0006812|GO:2001141|GO:0030554|GO:0016310|GO:0042981|GO:0050801|GO:0004672|GO:0006464|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0006468|GO:1903506|GO:0018193|GO:0004674|GO:0002028|GO:0030001|GO:0030003|GO:0015672|GO:0006814|GO:0055065|GO:0006875|GO:0018105|GO:0006883|GO:0055078 locomotion|growth|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|cellular component organization|membrane-bounded organelle|lipid binding|regulation of growth|biosynthetic process|channel regulator activity|intracellular|protein binding|endomembrane system|transferase activity|regulation of metabolic process|regulation of cell proliferation|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|phospholipid binding|nucleoside binding|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|vesicle|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|calcium channel regulator activity|movement of cell or subcellular component|homeostatic process|potassium channel regulator activity|cellular homeostasis|nucleobase-containing compound metabolic process|cell communication|transmembrane transport|regulation of cellular component movement|cell migration|signal transduction|cell death|sodium channel regulator activity|nucleotide binding|chloride channel regulator activity|regulation of cell motility|cellular biosynthetic process|protein metabolic process|regulation of cell growth|regulation of cellular metabolic process|positive regulation of transporter activity|endosome|regulation of sequence-specific DNA binding transcription factor activity|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|macromolecule modification|cytoplasmic vesicle|early endosome|chemical homeostasis|phosphatidylinositol binding|regulation of RNA metabolic process|purine nucleoside binding|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|protein modification process|ion transport|ribonucleoside binding|cellular chemical homeostasis|recycling endosome|membrane-bounded vesicle|kinase activity|regulation of ion transport|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|positive regulation of sodium ion transport|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|regulation of programmed cell death|ion transmembrane transport|RNA biosynthetic process|ATP binding|cation transport|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|regulation of apoptotic process|ion homeostasis|protein kinase activity|cellular protein modification process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|protein phosphorylation|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|protein serine/threonine kinase activity|regulation of sodium ion transport|metal ion transport|cellular cation homeostasis|monovalent inorganic cation transport|sodium ion transport|metal ion homeostasis|cellular metal ion homeostasis|peptidyl-serine phosphorylation|cellular sodium ion homeostasis|sodium ion homeostasis K13304 serum/glucocorticoid-regulated kinase 3[2.7.11.1] hsa04151|hsa04068 PI3K-Akt signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human) 8:66712418-66862022 12 0 15 115 126 106 0.0602804300757618 0 0.0679333479458765 0.517580857551756 0.519303232693226 0.499020432310278 0.0427379260072128 0.511968174185087 -3.58246532633287 2.70568452450082e-13 1.03293485670649e-11 DOWN ENSG00000197157 SND1 staphylococcal nuclease and tudor domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30646] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0000988|GO:0003824|GO:1903561|GO:0097159|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0016032|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0030529|GO:0016458|GO:0006139|GO:0070062|GO:0001503|GO:0048869|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0003723|GO:0031410|GO:0031047|GO:0010629|GO:0097433|GO:0051252|GO:0016023|GO:0001649|GO:0004518|GO:0031988|GO:0005739|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0016442|GO:0032774|GO:2001141|GO:0044822|GO:0090305|GO:0006351|GO:0006355|GO:1903506|GO:0042470 developmental process|macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|transcription factor activity, protein binding|catalytic activity|extracellular vesicle|organic cyclic compound binding|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|regulation of metabolic process|viral process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|gene silencing|nucleobase-containing compound metabolic process|extracellular exosome|ossification|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|cytoplasmic vesicle|gene silencing by RNA|negative regulation of gene expression|dense body|regulation of RNA metabolic process|cytoplasmic, membrane-bounded vesicle|osteoblast differentiation|nuclease activity|membrane-bounded vesicle|mitochondrion|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RISC complex|RNA biosynthetic process|regulation of RNA biosynthetic process|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|melanosome K15979 staphylococcal nuclease domain-containing protein 1[-] hsa05203|hsa05169 Viral carcinogenesis - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human) 7:127652180-128092609 795 896 1823 4133 4807 5345 6.20156592978305 6.35217065639193 12.8213885906389 28.8866616199704 30.7663706927265 39.0760702595288 8.45837505893796 32.9097008574086 -1.96006047422883 3.11536369159268e-13 1.18781695592347e-11 DOWN ENSG00000144535 DIS3L2 DIS3 like 3'-5' exoribonuclease 2 [Source:HGNC Symbol;Acc:HGNC:28648] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0016787|GO:0005622|GO:0005515|GO:0042127|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043169|GO:0005737|GO:0030529|GO:0006139|GO:0008285|GO:0007059|GO:0051301|GO:0022613|GO:0019827|GO:0006996|GO:0035770|GO:0051276|GO:0000819|GO:0046872|GO:0003723|GO:1903047|GO:0051304|GO:0044265|GO:0042254|GO:0000278|GO:0004518|GO:0005844|GO:0007067|GO:0010467|GO:0019439|GO:0016070|GO:0036464|GO:0006401|GO:0006364|GO:0090501|GO:0006396|GO:0000287|GO:0034660|GO:0004527|GO:0016071|GO:0000070|GO:0004540|GO:0051306|GO:0090305|GO:0003727|GO:0000932|GO:0004532|GO:1990074|GO:0008408|GO:0006402|GO:0016072|GO:0008187|GO:0090503|GO:0010586|GO:0000956|GO:0010587|GO:0016075|GO:0000175|GO:0016896|GO:0008266|GO:0000291|GO:0034427 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|hydrolase activity|intracellular|protein binding|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cation binding|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|negative regulation of cell proliferation|chromosome segregation|cell division|ribonucleoprotein complex biogenesis|stem cell population maintenance|organelle organization|ribonucleoprotein granule|chromosome organization|sister chromatid segregation|metal ion binding|RNA binding|mitotic cell cycle process|chromosome separation|cellular macromolecule catabolic process|ribosome biogenesis|mitotic cell cycle|nuclease activity|polysome|mitotic nuclear division|gene expression|aromatic compound catabolic process|RNA metabolic process|cytoplasmic ribonucleoprotein granule|RNA catabolic process|rRNA processing|RNA phosphodiester bond hydrolysis|RNA processing|magnesium ion binding|ncRNA metabolic process|exonuclease activity|mRNA metabolic process|mitotic sister chromatid segregation|ribonuclease activity|mitotic sister chromatid separation|nucleic acid phosphodiester bond hydrolysis|single-stranded RNA binding|cytoplasmic mRNA processing body|exoribonuclease activity|polyuridylation-dependent mRNA catabolic process|3'-5' exonuclease activity|mRNA catabolic process|rRNA metabolic process|poly-pyrimidine tract binding|RNA phosphodiester bond hydrolysis, exonucleolytic|miRNA metabolic process|nuclear-transcribed mRNA catabolic process|miRNA catabolic process|rRNA catabolic process|3'-5'-exoribonuclease activity|exoribonuclease activity, producing 5'-phosphomonoesters|poly(U) RNA binding|nuclear-transcribed mRNA catabolic process, exonucleolytic|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' - - - - 2:231961245-232344350 77 83 107 320 366 334 0.29200215838363 0.286059963395735 0.365843815620222 1.08728716741836 1.138795803503 1.1870577981785 0.314635312466529 1.13771358969995 -1.8543849134569 3.30341488236615e-13 1.25791004972142e-11 DOWN ENSG00000160058 BSDC1 BSD domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25501] - - - - - - 1:32365103-32394731 389 481 661 1501 1764 1556 2.0617899052405 2.31696558704408 3.15871354877798 7.1280849537802 7.67116013129473 7.7291768986815 2.51248968035419 7.50947399458548 -1.57959418620998 3.40719807875177e-13 1.29577696105803e-11 DOWN ENSG00000162231 NXF1 nuclear RNA export factor 1 [Source:HGNC Symbol;Acc:HGNC:8071] GO:0032991|GO:0005215|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0005487|GO:0043229|GO:0071704|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0016032|GO:0006810|GO:0003676|GO:0071166|GO:0043231|GO:0016234|GO:0005737|GO:0000346|GO:0005635|GO:0051649|GO:0006403|GO:0000166|GO:0005829|GO:0042405|GO:0003723|GO:0046907|GO:0031981|GO:0005654|GO:0050658|GO:0010467|GO:0005634|GO:0005643|GO:0051028|GO:0051169|GO:0016973|GO:0016604|GO:0044822|GO:0006406|GO:0006405|GO:0003727|GO:0016607|GO:0006913|GO:0003729|GO:0051168 macromolecular complex|transporter activity|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|nucleocytoplasmic transporter activity|intracellular organelle|organic substance metabolic process|cellular localization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|viral process|transport|nucleic acid binding|ribonucleoprotein complex localization|intracellular membrane-bounded organelle|inclusion body|cytoplasm|transcription export complex|nuclear envelope|establishment of localization in cell|RNA localization|nucleotide binding|cytosol|nuclear inclusion body|RNA binding|intracellular transport|nuclear lumen|nucleoplasm|RNA transport|gene expression|nucleus|nuclear pore|mRNA transport|nuclear transport|poly(A)+ mRNA export from nucleus|nuclear body|poly(A) RNA binding|mRNA export from nucleus|RNA export from nucleus|single-stranded RNA binding|nuclear speck|nucleocytoplasmic transport|mRNA binding|nuclear export K14284 nuclear RNA export factor[-] hsa05168|hsa05164|hsa03013|hsa03015|hsa03008 Herpes simplex infection - Homo sapiens (human)|Influenza A - Homo sapiens (human)|RNA transport - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human)|Ribosome biogenesis in eukaryotes - Homo sapiens (human) 11:62792123-62806302 2753 2535 2036 882 956 769 17.705113502666 14.8166673100324 11.8055013818773 5.08228498691507 5.0445040071716 4.63498092733446 14.7757607315252 4.92058997380704 1.58632920087642 3.43422146842439e-13 1.30439246460995e-11 UP ENSG00000046604 DSG2 desmoglein 2 [Source:HGNC Symbol;Acc:HGNC:3049] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0098900|GO:0050794|GO:0044702|GO:0043167|GO:0009986|GO:0045177|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0032504|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0048609|GO:0007507|GO:0016337|GO:0042391|GO:0009888|GO:0016324|GO:0007275|GO:0048513|GO:0044291|GO:0097194|GO:0031982|GO:0098609|GO:0043169|GO:0032970|GO:0003012|GO:0003161|GO:0006928|GO:0098901|GO:0050839|GO:0060135|GO:0007154|GO:0007565|GO:0051270|GO:0070062|GO:0016328|GO:0030057|GO:0009725|GO:0008219|GO:0002027|GO:0016021|GO:0030029|GO:0010033|GO:0003013|GO:0098742|GO:0006936|GO:0045216|GO:0046872|GO:0033993|GO:0072358|GO:0061337|GO:0030048|GO:0048738|GO:0034109|GO:0014704|GO:0090257|GO:0001508|GO:0003165|GO:0086091|GO:0098632|GO:0060537|GO:0012501|GO:0014070|GO:0034113|GO:0006921|GO:0072359|GO:0008015|GO:0048545|GO:0098911|GO:0086065|GO:0006941|GO:0008016|GO:0086080|GO:0070252|GO:0086001|GO:0086073|GO:0006937|GO:0032570|GO:0060047|GO:0086069|GO:0005509|GO:0086004|GO:0007156|GO:0003229|GO:0014706|GO:0002934|GO:0086042|GO:0006915|GO:0086003|GO:0006942|GO:0086002|GO:0060048|GO:0055117|GO:0086083|GO:0086005 developmental process|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|cell junction|response to stimulus|binding|extracellular vesicle|regulation of action potential|regulation of cellular process|single organism reproductive process|ion binding|cell surface|apical part of cell|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|multicellular organism reproduction|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|multicellular organismal reproductive process|heart development|single organismal cell-cell adhesion|regulation of membrane potential|tissue development|apical plasma membrane|multicellular organism development|animal organ development|cell-cell contact zone|execution phase of apoptosis|vesicle|cell-cell adhesion|cation binding|regulation of actin filament-based process|muscle system process|cardiac conduction system development|movement of cell or subcellular component|regulation of cardiac muscle cell action potential|cell adhesion molecule binding|maternal process involved in female pregnancy|cell communication|female pregnancy|regulation of cellular component movement|extracellular exosome|lateral plasma membrane|desmosome|response to hormone|cell death|regulation of heart rate|integral component of membrane|actin filament-based process|response to organic substance|circulatory system process|cell-cell adhesion via plasma-membrane adhesion molecules|muscle contraction|cell-cell junction organization|metal ion binding|response to lipid|cardiovascular system development|cardiac conduction|actin filament-based movement|cardiac muscle tissue development|homotypic cell-cell adhesion|intercalated disc|regulation of muscle system process|action potential|Purkinje myocyte development|regulation of heart rate by cardiac conduction|protein binding involved in cell-cell adhesion|muscle tissue development|programmed cell death|response to organic cyclic compound|heterotypic cell-cell adhesion|cellular component disassembly involved in execution phase of apoptosis|circulatory system development|blood circulation|response to steroid hormone|regulation of ventricular cardiac muscle cell action potential|cell communication involved in cardiac conduction|striated muscle contraction|regulation of heart contraction|protein binding involved in heterotypic cell-cell adhesion|actin-mediated cell contraction|cardiac muscle cell action potential|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|regulation of muscle contraction|response to progesterone|heart contraction|bundle of His cell to Purkinje myocyte communication|calcium ion binding|regulation of cardiac muscle cell contraction|homophilic cell adhesion via plasma membrane adhesion molecules|ventricular cardiac muscle tissue development|striated muscle tissue development|desmosome organization|cardiac muscle cell-cardiac muscle cell adhesion|apoptotic process|cardiac muscle cell contraction|regulation of striated muscle contraction|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|regulation of cardiac muscle contraction|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|ventricular cardiac muscle cell action potential K07597 desmoglein 2[-] hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 18:31498043-31549008 587 662 1727 4725 5251 5239 6.45361457080593 6.61458732136458 17.1187222557181 46.5440519037763 47.3668668497746 53.9811313934743 10.0623080492962 49.2973500490084 -2.29254883510089 3.46101142017159e-13 1.31289752144603e-11 DOWN ENSG00000069702 TGFBR3 transforming growth factor beta receptor III [Source:HGNC Symbol;Acc:HGNC:11774] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0004872|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0005578|GO:0006807|GO:0006950|GO:0016049|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0009986|GO:0044237|GO:0038023|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0002262|GO:0023057|GO:0009058|GO:0031224|GO:0005615|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0042127|GO:0008201|GO:0009897|GO:0006725|GO:0009888|GO:0048468|GO:0019838|GO:1901360|GO:0098797|GO:0007275|GO:0048513|GO:0034101|GO:0005102|GO:0034641|GO:0043168|GO:0016772|GO:0031982|GO:0046483|GO:0090287|GO:0022607|GO:0035265|GO:0051098|GO:0061061|GO:0005887|GO:0055017|GO:0046332|GO:0004888|GO:0005737|GO:0043235|GO:0071559|GO:0006928|GO:0009887|GO:0032403|GO:0042592|GO:0009966|GO:0048729|GO:0050673|GO:0019904|GO:0010646|GO:0090288|GO:0006139|GO:0031226|GO:0007154|GO:0051270|GO:0061383|GO:0016477|GO:0007165|GO:0009968|GO:0070062|GO:0019955|GO:0009725|GO:0051271|GO:0008285|GO:0001666|GO:0015026|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0005539|GO:0010033|GO:0031323|GO:0048732|GO:0060021|GO:0003205|GO:0000902|GO:0010468|GO:0005126|GO:0071773|GO:0034645|GO:0034698|GO:0030218|GO:0034673|GO:0090101|GO:0007166|GO:0050431|GO:0033993|GO:0003208|GO:0043412|GO:0030097|GO:0072358|GO:0060347|GO:0051252|GO:0031100|GO:0048738|GO:0003007|GO:0030165|GO:0000904|GO:0001889|GO:0036211|GO:0071560|GO:0060537|GO:0048872|GO:0060485|GO:0003231|GO:0070848|GO:0050678|GO:0006461|GO:0016301|GO:0050680|GO:0030511|GO:0060038|GO:0070542|GO:0006796|GO:0035556|GO:0044267|GO:0048864|GO:0048185|GO:0010467|GO:0071310|GO:0060415|GO:0009059|GO:0030154|GO:0007517|GO:0016070|GO:0072359|GO:0016773|GO:0017134|GO:0061384|GO:0048644|GO:0043393|GO:0048863|GO:0032354|GO:0060317|GO:0034622|GO:0032774|GO:2001141|GO:0014031|GO:0043623|GO:0071363|GO:0034699|GO:0016310|GO:0004675|GO:0007179|GO:0030512|GO:0030509|GO:0060318|GO:0007167|GO:0034695|GO:0003229|GO:0004672|GO:0048762|GO:0005160|GO:0030099|GO:0060216|GO:0055008|GO:0014706|GO:0006464|GO:0055010|GO:0001837|GO:0017015|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:0005114|GO:0006468|GO:1903506|GO:0007181|GO:0004674|GO:0005024|GO:0007178|GO:0060389|GO:0070123 locomotion|developmental process|extracellular matrix|growth|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|receptor activity|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|proteinaceous extracellular matrix|nitrogen compound metabolic process|response to stress|cell growth|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cell surface|cellular metabolic process|signaling receptor activity|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|myeloid cell homeostasis|negative regulation of signaling|biosynthetic process|intrinsic component of membrane|extracellular space|developmental growth|intracellular|immune system development|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|regulation of cell proliferation|heparin binding|external side of plasma membrane|cellular aromatic compound metabolic process|tissue development|cell development|growth factor binding|organic cyclic compound metabolic process|plasma membrane protein complex|multicellular organism development|animal organ development|erythrocyte homeostasis|receptor binding|cellular nitrogen compound metabolic process|anion binding|transferase activity, transferring phosphorus-containing groups|vesicle|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|cellular component assembly|organ growth|regulation of binding|muscle structure development|integral component of plasma membrane|cardiac muscle tissue growth|SMAD binding|transmembrane signaling receptor activity|cytoplasm|receptor complex|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|protein complex binding|homeostatic process|regulation of signal transduction|tissue morphogenesis|epithelial cell proliferation|protein domain specific binding|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|cell communication|regulation of cellular component movement|trabecula morphogenesis|cell migration|signal transduction|negative regulation of signal transduction|extracellular exosome|cytokine binding|response to hormone|negative regulation of cellular component movement|negative regulation of cell proliferation|response to hypoxia|coreceptor activity|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|glycosaminoglycan binding|response to organic substance|regulation of cellular metabolic process|gland development|palate development|cardiac chamber development|cell morphogenesis|regulation of gene expression|cytokine receptor binding|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|response to gonadotropin|erythrocyte differentiation|inhibin-betaglycan-ActRII complex|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|transforming growth factor beta binding|response to lipid|cardiac ventricle morphogenesis|macromolecule modification|hemopoiesis|cardiovascular system development|heart trabecula formation|regulation of RNA metabolic process|organ regeneration|cardiac muscle tissue development|heart morphogenesis|PDZ domain binding|cell morphogenesis involved in differentiation|liver development|protein modification process|cellular response to transforming growth factor beta stimulus|muscle tissue development|homeostasis of number of cells|mesenchyme development|cardiac ventricle development|response to growth factor|regulation of epithelial cell proliferation|protein complex assembly|kinase activity|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|cardiac muscle cell proliferation|response to fatty acid|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|stem cell development|activin binding|gene expression|cellular response to organic substance|muscle tissue morphogenesis|macromolecule biosynthetic process|cell differentiation|muscle organ development|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|fibroblast growth factor binding|heart trabecula morphogenesis|muscle organ morphogenesis|regulation of protein binding|stem cell differentiation|response to follicle-stimulating hormone|cardiac epithelial to mesenchymal transition|cellular macromolecular complex assembly|RNA biosynthetic process|regulation of RNA biosynthetic process|mesenchymal cell development|cellular protein complex assembly|cellular response to growth factor stimulus|response to luteinizing hormone|phosphorylation|transmembrane receptor protein serine/threonine kinase activity|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|BMP signaling pathway|definitive erythrocyte differentiation|enzyme linked receptor protein signaling pathway|response to prostaglandin E|ventricular cardiac muscle tissue development|protein kinase activity|mesenchymal cell differentiation|transforming growth factor beta receptor binding|myeloid cell differentiation|definitive hemopoiesis|cardiac muscle tissue morphogenesis|striated muscle tissue development|cellular protein modification process|ventricular cardiac muscle tissue morphogenesis|epithelial to mesenchymal transition|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|type II transforming growth factor beta receptor binding|protein phosphorylation|regulation of nucleic acid-templated transcription|transforming growth factor beta receptor complex assembly|protein serine/threonine kinase activity|transforming growth factor beta-activated receptor activity|transmembrane receptor protein serine/threonine kinase signaling pathway|pathway-restricted SMAD protein phosphorylation|transforming growth factor beta receptor activity, type III - - - - 1:91680343-91906335 88 79 163 471 459 563 0.339541732571544 0.277026525331607 0.567038788407379 1.62828711861302 1.45309078896683 2.0358658568255 0.39453568210351 1.70574792146845 -2.11217676863485 3.54245623759792e-13 1.34208741773158e-11 DOWN ENSG00000109685 WHSC1 Wolf-Hirschhorn syndrome candidate 1 [Source:HGNC Symbol;Acc:HGNC:12766] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0007507|GO:0002250|GO:0045830|GO:0003149|GO:0006281|GO:0016445|GO:0006725|GO:0050867|GO:1901360|GO:0045190|GO:0007275|GO:0060411|GO:0016570|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0002377|GO:0032880|GO:0009887|GO:0002696|GO:0001775|GO:0002312|GO:0002263|GO:0045184|GO:0009890|GO:0003682|GO:0006139|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0002366|GO:0050778|GO:0003279|GO:0060348|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0002443|GO:0006996|GO:0003205|GO:0048298|GO:0051276|GO:0051249|GO:0003677|GO:0008168|GO:0042113|GO:0010468|GO:0034645|GO:0046872|GO:0000725|GO:0043412|GO:0072358|GO:0010629|GO:0016447|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0003007|GO:0006302|GO:0036211|GO:0070201|GO:0060412|GO:0060413|GO:0051251|GO:0031981|GO:0003231|GO:2001020|GO:0005654|GO:0003209|GO:0006259|GO:0005694|GO:0002821|GO:0003283|GO:0002460|GO:0006282|GO:0045191|GO:0051054|GO:0002381|GO:0044267|GO:0002639|GO:0010467|GO:0002819|GO:0002637|GO:0009059|GO:0001501|GO:0003281|GO:0016070|GO:0072359|GO:0005634|GO:0006974|GO:0006303|GO:0000724|GO:0045892|GO:0032774|GO:0043565|GO:0003290|GO:2001141|GO:1902679|GO:0050871|GO:2000779|GO:0003285|GO:0018022|GO:0000018|GO:0050864|GO:0008276|GO:0006310|GO:0034968|GO:0046914|GO:0016568|GO:0019724|GO:0003284|GO:0006464|GO:0003289|GO:0002204|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0016064|GO:0006366|GO:1903507|GO:0006357|GO:0016279|GO:1903506|GO:0034770|GO:0018193|GO:0016444|GO:0042054|GO:0000122|GO:2001032|GO:0008270|GO:0010452|GO:0018024|GO:0002891|GO:0018205|GO:0042799 developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|methylation|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|heart development|adaptive immune response|positive regulation of isotype switching|membranous septum morphogenesis|DNA repair|somatic diversification of immunoglobulins|cellular aromatic compound metabolic process|positive regulation of cell activation|organic cyclic compound metabolic process|isotype switching|multicellular organism development|cardiac septum morphogenesis|histone modification|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|immunoglobulin production|regulation of protein localization|organ morphogenesis|positive regulation of leukocyte activation|cell activation|B cell activation involved in immune response|cell activation involved in immune response|establishment of protein localization|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|leukocyte activation involved in immune response|positive regulation of immune response|cardiac septum development|bone development|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|leukocyte mediated immunity|organelle organization|cardiac chamber development|positive regulation of isotype switching to IgA isotypes|chromosome organization|regulation of lymphocyte activation|DNA binding|methyltransferase activity|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|recombinational repair|macromolecule modification|cardiovascular system development|negative regulation of gene expression|somatic recombination of immunoglobulin gene segments|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|heart morphogenesis|double-strand break repair|protein modification process|regulation of establishment of protein localization|ventricular septum morphogenesis|atrial septum morphogenesis|positive regulation of lymphocyte activation|nuclear lumen|cardiac ventricle development|regulation of response to DNA damage stimulus|nucleoplasm|cardiac atrium morphogenesis|DNA metabolic process|chromosome|positive regulation of adaptive immune response|atrial septum development|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|regulation of DNA repair|regulation of isotype switching|positive regulation of DNA metabolic process|immunoglobulin production involved in immunoglobulin mediated immune response|cellular protein metabolic process|positive regulation of immunoglobulin production|gene expression|regulation of adaptive immune response|regulation of immunoglobulin production|macromolecule biosynthetic process|skeletal system development|ventricular septum development|RNA metabolic process|circulatory system development|nucleus|cellular response to DNA damage stimulus|double-strand break repair via nonhomologous end joining|double-strand break repair via homologous recombination|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|atrial septum secundum morphogenesis|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|positive regulation of B cell activation|regulation of double-strand break repair|septum secundum development|peptidyl-lysine methylation|regulation of DNA recombination|regulation of B cell activation|protein methyltransferase activity|DNA recombination|histone lysine methylation|transition metal ion binding|chromatin modification|B cell mediated immunity|septum primum development|cellular protein modification process|atrial septum primum morphogenesis|somatic recombination of immunoglobulin genes involved in immune response|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|immunoglobulin mediated immune response|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|protein-lysine N-methyltransferase activity|regulation of nucleic acid-templated transcription|histone H4-K20 methylation|peptidyl-amino acid modification|somatic cell DNA recombination|histone methyltransferase activity|negative regulation of transcription from RNA polymerase II promoter|regulation of double-strand break repair via nonhomologous end joining|zinc ion binding|histone H3-K36 methylation|histone-lysine N-methyltransferase activity|positive regulation of immunoglobulin mediated immune response|peptidyl-lysine modification|histone methyltransferase activity (H4-K20 specific) K11424 histone-lysine N-methyltransferase NSD2[2.1.1.43] hsa05202|hsa00310 Transcriptional misregulation in cancer - Homo sapiens (human)|Lysine degradation - Homo sapiens (human) 4:1871424-1982207 501 919 721 2355 2699 2363 0.944716189861613 1.57492394329002 1.22578325896196 3.97880400419722 4.17575235251803 4.17596274627222 1.24847446403786 4.11017303432916 -1.71903281818811 3.57937625146015e-13 1.35435612941814e-11 DOWN ENSG00000142794 NBPF3 neuroblastoma breakpoint family member 3 [Source:HGNC Symbol;Acc:HGNC:25076] GO:0005623|GO:0009987|GO:0050794|GO:0051050|GO:0051641|GO:0016043|GO:0005622|GO:1903829|GO:0060341|GO:0006810|GO:0051130|GO:0051128|GO:0005737|GO:0032880|GO:0051222|GO:0045184|GO:0032388|GO:0008104|GO:0051649|GO:0090316|GO:0006996|GO:0072594|GO:0007005|GO:0032386|GO:0051223|GO:1903955|GO:0015031|GO:0070201|GO:0046907|GO:0034613|GO:0033043|GO:0006626|GO:1903827|GO:0010638|GO:0033365|GO:0033157|GO:0006839|GO:0006605|GO:0072655|GO:0010822|GO:0016482|GO:0006886|GO:0010821|GO:1903214|GO:1903533|GO:0070585 cell|cellular process|regulation of cellular process|positive regulation of transport|cellular localization|cellular component organization|intracellular|positive regulation of cellular protein localization|regulation of cellular localization|transport|positive regulation of cellular component organization|regulation of cellular component organization|cytoplasm|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|positive regulation of intracellular transport|protein localization|establishment of localization in cell|positive regulation of intracellular protein transport|organelle organization|establishment of protein localization to organelle|mitochondrion organization|regulation of intracellular transport|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|regulation of establishment of protein localization|intracellular transport|cellular protein localization|regulation of organelle organization|protein targeting to mitochondrion|regulation of cellular protein localization|positive regulation of organelle organization|protein localization to organelle|regulation of intracellular protein transport|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|regulation of protein targeting to mitochondrion|regulation of protein targeting|protein localization to mitochondrion - - - - 1:21440128-21485005 171 135 190 575 599 619 0.972894915322276 0.698046827421559 0.974623673900658 2.93113005258546 2.79617775396142 3.30057300020806 0.881855138881498 3.00929360225165 -1.77081127948154 3.61572966262689e-13 1.36637966263371e-11 DOWN ENSG00000214113 LYRM4 LYR motif containing 4 [Source:HGNC Symbol;Acc:HGNC:21365] GO:0005623|GO:0008152|GO:0043229|GO:0043227|GO:0005622|GO:0044281|GO:0043231|GO:0005737|GO:0005759|GO:0005739|GO:0005634 cell|metabolic process|intracellular organelle|membrane-bounded organelle|intracellular|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial matrix|mitochondrion|nucleus - - - - 6:5102593-5260939 47 41 105 397 390 302 0.225889598514472 0.179087498974026 0.454989033073147 1.70956195740255 1.53790558304638 1.36029580833573 0.286655376853882 1.53592111626155 -2.42171487691285 3.72226425396475e-13 1.40486064523216e-11 DOWN ENSG00000107854 TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 [Source:HGNC Symbol;Acc:HGNC:15677] GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0006486|GO:0032205|GO:0006725|GO:0051130|GO:1901360|GO:0034641|GO:0032204|GO:0031325|GO:0046483|GO:0051128|GO:0032206|GO:0043231|GO:0000723|GO:0043169|GO:0019899|GO:0005737|GO:0005975|GO:0005635|GO:0035264|GO:0042592|GO:0009966|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0048638|GO:0016757|GO:0040014|GO:0009967|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0005794|GO:0006996|GO:0051276|GO:0030111|GO:0005829|GO:0005813|GO:0007004|GO:0034645|GO:0051053|GO:0046872|GO:0007166|GO:0010833|GO:0043412|GO:0005815|GO:0009100|GO:0036211|GO:1904358|GO:0031981|GO:0048471|GO:0070085|GO:0006259|GO:0005694|GO:0000228|GO:0034613|GO:0006471|GO:0051054|GO:1901137|GO:0033043|GO:0044267|GO:0016763|GO:0000139|GO:0031328|GO:1904355|GO:0030177|GO:1904356|GO:0009059|GO:0016233|GO:0005856|GO:0010557|GO:0005634|GO:1904357|GO:0010638|GO:2001252|GO:0016055|GO:0009101|GO:0043413|GO:0033365|GO:0032200|GO:0006260|GO:0000781|GO:2001251|GO:0060828|GO:0033044|GO:0070213|GO:0032212|GO:0015630|GO:0006275|GO:0000784|GO:0045740|GO:0006464|GO:0000242|GO:0090263|GO:0032210|GO:0003950|GO:0006278|GO:0034502|GO:0060070|GO:0032446|GO:0070198|GO:0016567|GO:0000209 developmental process|growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|protein glycosylation|negative regulation of telomere maintenance|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|regulation of telomere maintenance|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of telomere maintenance|intracellular membrane-bounded organelle|telomere maintenance|cation binding|enzyme binding|cytoplasm|carbohydrate metabolic process|nuclear envelope|multicellular organism growth|homeostatic process|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|regulation of developmental growth|transferase activity, transferring glycosyl groups|regulation of multicellular organism growth|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|chromosome organization|regulation of Wnt signaling pathway|cytosol|centrosome|telomere maintenance via telomerase|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|metal ion binding|cell surface receptor signaling pathway|telomere maintenance via telomere lengthening|macromolecule modification|microtubule organizing center|glycoprotein metabolic process|protein modification process|positive regulation of telomere maintenance via telomere lengthening|nuclear lumen|perinuclear region of cytoplasm|glycosylation|DNA metabolic process|chromosome|nuclear chromosome|cellular protein localization|protein ADP-ribosylation|positive regulation of DNA metabolic process|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|transferase activity, transferring pentosyl groups|Golgi membrane|positive regulation of cellular biosynthetic process|positive regulation of telomere capping|positive regulation of Wnt signaling pathway|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|telomere capping|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|negative regulation of telomere maintenance via telomere lengthening|positive regulation of organelle organization|positive regulation of chromosome organization|Wnt signaling pathway|glycoprotein biosynthetic process|macromolecule glycosylation|protein localization to organelle|telomere organization|DNA replication|chromosome, telomeric region|negative regulation of chromosome organization|regulation of canonical Wnt signaling pathway|regulation of chromosome organization|protein auto-ADP-ribosylation|positive regulation of telomere maintenance via telomerase|microtubule cytoskeleton|regulation of DNA replication|nuclear chromosome, telomeric region|positive regulation of DNA replication|cellular protein modification process|pericentriolar material|positive regulation of canonical Wnt signaling pathway|regulation of telomere maintenance via telomerase|NAD+ ADP-ribosyltransferase activity|RNA-dependent DNA replication|protein localization to chromosome|canonical Wnt signaling pathway|protein modification by small protein conjugation|protein localization to chromosome, telomeric region|protein ubiquitination|protein polyubiquitination - - - - 10:91798312-91865276 575 683 1175 2588 2895 3130 6.60608853861272 7.13143702203384 12.1710641578209 26.6402683742492 27.2893468269014 33.7015435623121 8.63619657282249 29.2103862544876 -1.7580134485682 3.87330816356483e-13 1.46002199387707e-11 DOWN ENSG00000172123 SLFN12 schlafen family member 12 [Source:HGNC Symbol;Acc:HGNC:25500] GO:0005488|GO:0036094|GO:0097159|GO:0043167|GO:0043168|GO:0001882|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005524|GO:0030554 binding|small molecule binding|organic cyclic compound binding|ion binding|anion binding|nucleoside binding|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|ATP binding|adenyl nucleotide binding - - - - 17:35411060-35433283 11 24 18 128 147 90 0.0904244419412277 0.179302178953825 0.133411381283073 0.942764980921169 0.991473888427311 0.693375103805816 0.134379334059375 0.875871324384765 -2.704407650961 3.87829182416899e-13 1.46005705067769e-11 DOWN ENSG00000198542 ITGBL1 integrin subunit beta like 1 [Source:HGNC Symbol;Acc:HGNC:6164] GO:0005576|GO:0005488|GO:0007155|GO:0005515 extracellular region|binding|cell adhesion|protein binding - - - - 13:101452593-101720856 40 68 107 356 416 312 0.270814992326225 0.418408933898997 0.65314746293683 2.15953427541047 2.31086322297392 1.97968622488638 0.447457129720684 2.15002790775692 -2.26453401498728 4.04614135237027e-13 1.52132876490758e-11 DOWN ENSG00000165102 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase [Source:HGNC Symbol;Acc:HGNC:26527] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0051641|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0016740|GO:0031090|GO:0006810|GO:0044281|GO:0022607|GO:0043231|GO:0016746|GO:0005774|GO:0005737|GO:0005975|GO:0051649|GO:0016021|GO:0005773|GO:0046907|GO:0016747|GO:0006461|GO:0051259|GO:0000323|GO:0016407|GO:0016410|GO:0030203|GO:0007034|GO:0005765|GO:0007041|GO:0005764|GO:0006027|GO:0008080|GO:0015019 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular localization|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|transferase activity|organelle membrane|transport|small molecule metabolic process|cellular component assembly|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|vacuolar membrane|cytoplasm|carbohydrate metabolic process|establishment of localization in cell|integral component of membrane|vacuole|intracellular transport|transferase activity, transferring acyl groups other than amino-acyl groups|protein complex assembly|protein oligomerization|lytic vacuole|acetyltransferase activity|N-acyltransferase activity|glycosaminoglycan metabolic process|vacuolar transport|lysosomal membrane|lysosomal transport|lysosome|glycosaminoglycan catabolic process|N-acetyltransferase activity|heparan-alpha-glucosaminide N-acetyltransferase activity K10532 heparan-alpha-glucosaminide N-acetyltransferase[2.3.1.78] hsa01100|hsa04142|hsa00531 Metabolic pathways - Homo sapiens (human)|Lysosome - Homo sapiens (human)|Glycosaminoglycan degradation - Homo sapiens (human) 8:43140455-43202855 105 112 137 416 465 392 0.58185574185478 0.564056234457954 0.68447783034169 2.06545530979041 2.11420106203974 2.03582107000266 0.610129935551475 2.07182581394427 -1.76371429318065 4.13207721008758e-13 1.55168595006232e-11 DOWN ENSG00000144233 AMMECR1L AMMECR1 like [Source:HGNC Symbol;Acc:HGNC:28658] - - - - - - 2:127861630-127885922 2731 2876 2125 961 1009 820 23.1911571152478 22.1957411976791 16.2694905407497 7.31175456341857 7.03007369097547 6.52594853955796 20.5521296178922 6.955925597984 1.56297348767385 4.34411602980437e-13 1.62926180846457e-11 UP ENSG00000149289 ZC3H12C zinc finger CCCH-type containing 12C [Source:HGNC Symbol;Acc:HGNC:29362] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0006725|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0043169|GO:0006139|GO:0046872|GO:0004518|GO:0004519|GO:0090305 cellular process|metabolic process|binding|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cation binding|nucleobase-containing compound metabolic process|metal ion binding|nuclease activity|endonuclease activity|nucleic acid phosphodiester bond hydrolysis - - - - 11:110093361-110171841 144 160 207 520 635 592 0.520655126312515 0.52575998429008 0.67479501366664 1.68457132211967 1.88377756422286 2.00603646678273 0.573736708089745 1.85812845104175 -1.69538950687798 4.42826796765777e-13 1.65873917072089e-11 DOWN ENSG00000115128 SF3B6 splicing factor 3b subunit 6 [Source:HGNC Symbol;Acc:HGNC:30096] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0005622|GO:0048856|GO:0048646|GO:0001824|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0001825|GO:0043231|GO:0030529|GO:0006139|GO:0000166|GO:0003723|GO:0030532|GO:0009790|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0097525|GO:0009792|GO:0006396|GO:0071011|GO:0005689|GO:0005684|GO:0016071|GO:0044822|GO:0071013|GO:0005686|GO:0006397|GO:0043009|GO:0008380|GO:0000375|GO:0001701|GO:0000398 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|blastocyst development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|blastocyst formation|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|nucleotide binding|RNA binding|small nuclear ribonucleoprotein complex|embryo development|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|spliceosomal snRNP complex|embryo development ending in birth or egg hatching|RNA processing|precatalytic spliceosome|U12-type spliceosomal complex|U2-type spliceosomal complex|mRNA metabolic process|poly(A) RNA binding|catalytic step 2 spliceosome|U2 snRNP|mRNA processing|chordate embryonic development|RNA splicing|RNA splicing, via transesterification reactions|in utero embryonic development|mRNA splicing, via spliceosome K12833 pre-mRNA branch site protein p14[-] hsa03040 Spliceosome - Homo sapiens (human) 2:24067584-24076443 529 566 742 1976 2106 1602 25.1139669226343 24.420586460449 31.7598074571773 84.0512301671882 82.0324718844395 71.2772427925707 27.0981202800869 79.1203149480661 -1.5458553895541 4.46526231745209e-13 1.6705005166067e-11 DOWN ENSG00000223546 LINC00630 long intergenic non-protein coding RNA 630 [Source:HGNC Symbol;Acc:HGNC:44263] - - - - - - X:102769161-102885406 8 8 6 78 52 83 0.11838253213082 0.107593811010995 0.0800561322134479 1.03420798089895 0.63138267044138 1.15113431670599 0.102010825118421 0.938908322682107 -3.20226204116904 4.65931222362828e-13 1.74091498278096e-11 DOWN ENSG00000111790 FGFR1OP2 FGFR1 oncogene partner 2 [Source:HGNC Symbol;Acc:HGNC:23098] GO:0005623|GO:0050896|GO:0005488|GO:0006950|GO:0005622|GO:0005515|GO:0042802|GO:0005737|GO:0009611|GO:0046983|GO:0005829|GO:0042060|GO:0042803 cell|response to stimulus|binding|response to stress|intracellular|protein binding|identical protein binding|cytoplasm|response to wounding|protein dimerization activity|cytosol|wound healing|protein homodimerization activity - - - - 12:26938383-26966650 2288 2171 2211 903 998 794 16.6645331315461 14.3706698709087 14.5191140011795 5.89280830915407 5.96397332672389 5.41984250457639 15.1847723345448 5.75887471348478 1.39876643721787 4.86007899183804e-13 1.81365997777916e-11 UP ENSG00000164379 FOXQ1 forkhead box Q1 [Source:HGNC Symbol;Acc:HGNC:20951] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031069|GO:0046483|GO:0043231|GO:0001942|GO:0000981|GO:0048729|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0002009|GO:0022405|GO:0051252|GO:0043588|GO:0060429|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0042633|GO:0032774|GO:0043565|GO:2001141|GO:0008544|GO:0048730|GO:0006351|GO:0006355|GO:0098773|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|hair follicle morphogenesis|heterocycle metabolic process|intracellular membrane-bounded organelle|hair follicle development|RNA polymerase II transcription factor activity, sequence-specific DNA binding|tissue morphogenesis|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|morphogenesis of an epithelium|hair cycle process|regulation of RNA metabolic process|skin development|epithelium development|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|hair cycle|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|epidermis development|epidermis morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|skin epidermis development|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 6:1312473-1314187 334 476 360 1216 1348 1175 13.776172863451 17.8430417719841 13.3874623811272 44.9378938327797 45.6183453527562 45.4201473161076 15.0022256721874 45.3254621672145 -1.59514518142319 4.89769170126883e-13 1.82541433270511e-11 DOWN ENSG00000145781 COMMD10 COMM domain containing 10 [Source:HGNC Symbol;Acc:HGNC:30201] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 5:116084991-116412762 36 34 17 198 225 162 0.531636907731052 0.456319054423458 0.226345200368948 2.61982463228997 2.72621888009035 2.24209406460292 0.404767054174486 2.52937919232775 -2.64361956266238 4.96451405232302e-13 1.84801250022508e-11 DOWN ENSG00000030419 IKZF2 IKAROS family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:13177] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0046983|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0046982|GO:0051252|GO:0010628|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0042803|GO:0000975|GO:0045893|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|protein dimerization activity|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|protein heterodimerization activity|regulation of RNA metabolic process|positive regulation of gene expression|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding - - - - 2:212999691-213152427 48 34 63 225 252 403 0.160210614042831 0.103136331368299 0.189586993500795 0.672873635160075 0.690114571991841 1.26063040585286 0.150977979637308 0.874539537668259 -2.53418546375004 4.98756901485298e-13 1.85428250771384e-11 DOWN ENSG00000049167 ERCC8 excision repair cross-complementation group 8 [Source:HGNC Symbol;Acc:HGNC:3439] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006281|GO:0006725|GO:0009314|GO:1901360|GO:2001022|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0032403|GO:0006979|GO:0006139|GO:0019787|GO:0000151|GO:0019538|GO:1990391|GO:0031323|GO:0043412|GO:0030163|GO:0004842|GO:0031461|GO:0044265|GO:0036211|GO:0045739|GO:0031981|GO:2001020|GO:1990234|GO:0006508|GO:0005654|GO:0006259|GO:0016363|GO:0006282|GO:0051054|GO:0010212|GO:0044267|GO:0034399|GO:0006289|GO:0005634|GO:0009416|GO:0006974|GO:0000109|GO:0044257|GO:0009411|GO:0010498|GO:0006283|GO:0051603|GO:0010165|GO:0080008|GO:0006464|GO:0019941|GO:0031464|GO:0043161|GO:0032446|GO:0006511|GO:0016567|GO:0051865|GO:0000209 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|protein complex binding|response to oxidative stress|nucleobase-containing compound metabolic process|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|DNA repair complex|regulation of cellular metabolic process|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|cellular macromolecule catabolic process|protein modification process|positive regulation of DNA repair|nuclear lumen|regulation of response to DNA damage stimulus|transferase complex|proteolysis|nucleoplasm|DNA metabolic process|nuclear matrix|regulation of DNA repair|positive regulation of DNA metabolic process|response to ionizing radiation|cellular protein metabolic process|nuclear periphery|nucleotide-excision repair|nucleus|response to light stimulus|cellular response to DNA damage stimulus|nucleotide-excision repair complex|cellular protein catabolic process|response to UV|proteasomal protein catabolic process|transcription-coupled nucleotide-excision repair|proteolysis involved in cellular protein catabolic process|response to X-ray|Cul4-RING E3 ubiquitin ligase complex|cellular protein modification process|modification-dependent protein catabolic process|Cul4A-RING E3 ubiquitin ligase complex|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein autoubiquitination|protein polyubiquitination K10570 DNA excision repair protein ERCC-8[-] hsa04120|hsa03420 Ubiquitin mediated proteolysis - Homo sapiens (human)|Nucleotide excision repair - Homo sapiens (human) 5:60873831-60945073 38 66 50 249 295 208 0.367666244553148 0.580353157874242 0.436169587126513 2.15856754128019 2.34185073533982 1.8860891748496 0.461396329851301 2.12883581715654 -2.20598625532776 5.07500416418419e-13 1.88444246663625e-11 DOWN ENSG00000115504 EHBP1 EH domain binding protein 1 [Source:HGNC Symbol;Acc:HGNC:29144] GO:0005623|GO:0016020|GO:0005488|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0005737 cell|membrane|binding|cell periphery|intracellular|protein binding|plasma membrane|cytoplasm - - - - 2:62673851-63046487 266 436 529 1445 1442 1295 1.58410415360731 2.35976802119802 2.84035093479424 7.71023928974507 7.04588505620473 7.22771757256747 2.26140770319986 7.32794730617242 -1.69618801413295 5.11764585796259e-13 1.8979155210387e-11 DOWN ENSG00000172456 FGGY FGGY carbohydrate kinase domain containing [Source:HGNC Symbol;Acc:HGNC:25610] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0071704|GO:0044237|GO:0005622|GO:0016740|GO:0016772|GO:0005737|GO:0005975|GO:0042592|GO:0019725|GO:0070050|GO:0016301|GO:0006796|GO:0016773|GO:0016310 cell|cellular process|metabolic process|catalytic activity|organic substance metabolic process|cellular metabolic process|intracellular|transferase activity|transferase activity, transferring phosphorus-containing groups|cytoplasm|carbohydrate metabolic process|homeostatic process|cellular homeostasis|neuron cellular homeostasis|kinase activity|phosphate-containing compound metabolic process|phosphotransferase activity, alcohol group as acceptor|phosphorylation - - - - 1:59296638-59810647 23 17 29 119 150 114 0.0859104097175595 0.0577101362341351 0.0976623790119243 0.398252035403484 0.459695123559626 0.399064932454065 0.0804276416545396 0.419004030472392 -2.38120079928239 5.16410877812833e-13 1.91277051441989e-11 DOWN ENSG00000068366 ACSL4 acyl-CoA synthetase long-chain family member 4 [Source:HGNC Symbol;Acc:HGNC:3571] GO:0032502|GO:0040007|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0050794|GO:0043229|GO:0016049|GO:0044702|GO:0042175|GO:0071704|GO:0043167|GO:0051051|GO:0044237|GO:0044297|GO:0044232|GO:0016043|GO:0045927|GO:0043227|GO:0019867|GO:0040008|GO:0009605|GO:0032504|GO:0009058|GO:0031224|GO:0016874|GO:0005622|GO:0005789|GO:0012505|GO:0048856|GO:0031090|GO:0048609|GO:0044255|GO:0060136|GO:0048468|GO:0043025|GO:0032369|GO:0006810|GO:0006082|GO:0009991|GO:0007275|GO:0016358|GO:0043168|GO:0030307|GO:0044281|GO:0001882|GO:0031982|GO:0051128|GO:0043231|GO:0005737|GO:0031966|GO:0036477|GO:0051186|GO:0060996|GO:0007565|GO:0006629|GO:0005783|GO:0070062|GO:0044233|GO:0051048|GO:0000166|GO:0030030|GO:0048869|GO:0016021|GO:0044249|GO:0010876|GO:0010033|GO:0001558|GO:0043271|GO:0006790|GO:0007584|GO:0005740|GO:0031175|GO:0046486|GO:0035639|GO:0034097|GO:0006637|GO:0005741|GO:0006631|GO:0005811|GO:0001883|GO:0009790|GO:0006811|GO:0032549|GO:0051046|GO:0006638|GO:0032368|GO:0006869|GO:0016878|GO:0005739|GO:0043269|GO:0032304|GO:0008610|GO:0007399|GO:0046903|GO:0017076|GO:0030154|GO:0031667|GO:0015645|GO:0005778|GO:0048666|GO:0030182|GO:0006820|GO:0015711|GO:0047676|GO:0009792|GO:0005777|GO:0031957|GO:0070672|GO:0005524|GO:0001676|GO:0030554|GO:0015908|GO:0009108|GO:0032307|GO:0046942|GO:0044070|GO:0019752|GO:2000191|GO:0006639|GO:0022008|GO:0046717|GO:0004467|GO:0015732|GO:0015718|GO:0048699|GO:0046949|GO:0032787|GO:0035336|GO:0006641|GO:0019432|GO:0035338 developmental process|growth|reproduction|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|regulation of cellular process|intracellular organelle|cell growth|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|negative regulation of transport|cellular metabolic process|cell body|organelle membrane contact site|cellular component organization|positive regulation of growth|membrane-bounded organelle|outer membrane|regulation of growth|response to external stimulus|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|ligase activity|intracellular|endoplasmic reticulum membrane|endomembrane system|anatomical structure development|organelle membrane|multicellular organismal reproductive process|cellular lipid metabolic process|embryonic process involved in female pregnancy|cell development|neuronal cell body|negative regulation of lipid transport|transport|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|dendrite development|anion binding|positive regulation of cell growth|small molecule metabolic process|nucleoside binding|vesicle|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|somatodendritic compartment|cofactor metabolic process|dendritic spine development|female pregnancy|lipid metabolic process|endoplasmic reticulum|extracellular exosome|ER-mitochondrion membrane contact site|negative regulation of secretion|nucleotide binding|cell projection organization|cellular developmental process|integral component of membrane|cellular biosynthetic process|lipid localization|response to organic substance|regulation of cell growth|negative regulation of ion transport|sulfur compound metabolic process|response to nutrient|mitochondrial envelope|neuron projection development|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|response to cytokine|acyl-CoA metabolic process|mitochondrial outer membrane|fatty acid metabolic process|lipid particle|purine nucleoside binding|embryo development|ion transport|ribonucleoside binding|regulation of secretion|neutral lipid metabolic process|regulation of lipid transport|lipid transport|acid-thiol ligase activity|mitochondrion|regulation of ion transport|negative regulation of icosanoid secretion|lipid biosynthetic process|nervous system development|secretion|purine nucleotide binding|cell differentiation|response to nutrient levels|fatty acid ligase activity|peroxisomal membrane|neuron development|neuron differentiation|anion transport|organic anion transport|arachidonate-CoA ligase activity|embryo development ending in birth or egg hatching|peroxisome|very long-chain fatty acid-CoA ligase activity|response to interleukin-15|ATP binding|long-chain fatty acid metabolic process|adenyl nucleotide binding|fatty acid transport|coenzyme biosynthetic process|negative regulation of prostaglandin secretion|carboxylic acid transport|regulation of anion transport|carboxylic acid metabolic process|regulation of fatty acid transport|acylglycerol metabolic process|neurogenesis|acid secretion|long-chain fatty acid-CoA ligase activity|prostaglandin transport|monocarboxylic acid transport|generation of neurons|fatty-acyl-CoA biosynthetic process|monocarboxylic acid metabolic process|long-chain fatty-acyl-CoA metabolic process|triglyceride metabolic process|triglyceride biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process K01897 long-chain acyl-CoA synthetase[6.2.1.3] hsa01100|hsa04146|hsa04920|hsa03320|hsa01212|hsa00071|hsa00061 Metabolic pathways - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Fatty acid metabolism - Homo sapiens (human)|Fatty acid degradation - Homo sapiens (human)|Fatty acid biosynthesis - Homo sapiens (human) X:109624244-109733403 275 360 721 1580 2192 2265 2.01539829398627 2.39778582143235 4.76407038887692 10.3748807349317 13.1806537702195 15.5569872827278 3.05908483476518 13.0375072626263 -2.09149603491941 5.35027003055141e-13 1.97926841997623e-11 DOWN ENSG00000011114 BTBD7 BTB (POZ) domain containing 7 [Source:HGNC Symbol;Acc:HGNC:18269] GO:0032502|GO:0005623|GO:0005488|GO:0043229|GO:0009653|GO:0043227|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0009888|GO:0007275|GO:0048513|GO:0043231|GO:0001763|GO:0009887|GO:0048729|GO:0060688|GO:0048732|GO:0002009|GO:0060693|GO:0061138|GO:0022612|GO:2000027|GO:0007431|GO:0035272|GO:0060429|GO:0005634|GO:0060445|GO:0007435 developmental process|cell|binding|intracellular organelle|anatomical structure morphogenesis|membrane-bounded organelle|regulation of developmental process|intracellular|protein binding|anatomical structure development|tissue development|multicellular organism development|animal organ development|intracellular membrane-bounded organelle|morphogenesis of a branching structure|organ morphogenesis|tissue morphogenesis|regulation of morphogenesis of a branching structure|gland development|morphogenesis of an epithelium|regulation of branching involved in salivary gland morphogenesis|morphogenesis of a branching epithelium|gland morphogenesis|regulation of organ morphogenesis|salivary gland development|exocrine system development|epithelium development|nucleus|branching involved in salivary gland morphogenesis|salivary gland morphogenesis - - - - 14:93237550-93333092 157 197 256 652 691 681 0.674911354602166 0.769652320524738 0.992207889458294 2.51126741409853 2.43721483432424 2.74361798494428 0.812257188195066 2.56403341112235 -1.65840655031394 5.47747422319912e-13 2.02381826063597e-11 DOWN ENSG00000119471 HSDL2 hydroxysteroid dehydrogenase like 2 [Source:HGNC Symbol;Acc:HGNC:18572] GO:0005623|GO:0016020|GO:0008152|GO:0003824|GO:0016491|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0055114|GO:0005739|GO:0005777 cell|membrane|metabolic process|catalytic activity|oxidoreductase activity|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|oxidation-reduction process|mitochondrion|peroxisome - - - - 9:112379937-112472410 714 789 1181 2626 2961 2687 8.77603528726347 8.81368768277314 13.0877342018564 28.919642165265 29.8611634951659 30.9525893379333 10.2258190572977 29.9111316661214 -1.54846609149629 5.57494547472909e-13 2.05728581214539e-11 DOWN ENSG00000088356 PDRG1 p53 and DNA damage regulated 1 [Source:HGNC Symbol;Acc:HGNC:16119] GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0006457|GO:0005622|GO:0005515|GO:0043234|GO:0005737|GO:0016272|GO:0051082 macromolecular complex|cell|cellular process|binding|protein folding|intracellular|protein binding|protein complex|cytoplasm|prefoldin complex|unfolded protein binding - - - - 20:31944342-31952092 992 967 699 292 319 200 35.1205912067446 31.1140702624794 22.3121572820382 9.26254643597361 9.26634076739522 6.6360567955722 29.5156062504207 8.38831466631368 1.81502508843808 5.58621721109491e-13 2.05890035333367e-11 UP ENSG00000141682 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 [Source:HGNC Symbol;Acc:HGNC:9108] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0044089|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0051641|GO:0001776|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0019867|GO:0009607|GO:0009605|GO:0009893|GO:0005622|GO:1903829|GO:0005515|GO:0031090|GO:0019222|GO:0060341|GO:0044262|GO:0042127|GO:0042391|GO:0009314|GO:0006810|GO:0051130|GO:2001022|GO:0010941|GO:0009991|GO:0044281|GO:0006952|GO:0031325|GO:0051128|GO:0033554|GO:0022607|GO:0010942|GO:0098542|GO:0043231|GO:0048144|GO:0005737|GO:0031668|GO:0032880|GO:0005975|GO:0042592|GO:0072593|GO:0009615|GO:0009966|GO:0031966|GO:0045184|GO:0032388|GO:0010646|GO:0043085|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0002260|GO:0090559|GO:0051649|GO:0008219|GO:0008285|GO:0001666|GO:0051607|GO:0050790|GO:0051204|GO:0009967|GO:0019538|GO:0031334|GO:0043254|GO:0010033|GO:0031323|GO:0042594|GO:0006996|GO:1902533|GO:2001235|GO:0032268|GO:0005740|GO:0045837|GO:0006109|GO:0005829|GO:0090150|GO:0007166|GO:0072594|GO:0030163|GO:0051345|GO:0007005|GO:0005741|GO:0032386|GO:1901216|GO:0070997|GO:0051604|GO:0032461|GO:0044265|GO:0046902|GO:0043331|GO:0071456|GO:0070201|GO:0046907|GO:0001844|GO:0048872|GO:1902235|GO:0043517|GO:0048145|GO:0043029|GO:0032459|GO:0072657|GO:2001020|GO:0051205|GO:0005996|GO:1900740|GO:0051247|GO:0006508|GO:0005739|GO:0009267|GO:0006461|GO:1901214|GO:0051881|GO:0071453|GO:0034613|GO:0032270|GO:0012501|GO:0014070|GO:1901030|GO:0010212|GO:0035556|GO:0033043|GO:0044267|GO:0010467|GO:0048147|GO:0051246|GO:0043068|GO:0031669|GO:1903827|GO:1902531|GO:0031667|GO:0034976|GO:0005634|GO:0009416|GO:0043067|GO:0006974|GO:0097190|GO:0007006|GO:0010638|GO:0070059|GO:0019318|GO:0044257|GO:1901028|GO:0097193|GO:2001242|GO:0033365|GO:1901798|GO:0042149|GO:0043065|GO:0009411|GO:0010498|GO:2001244|GO:0051259|GO:0016485|GO:0043523|GO:0072331|GO:0042770|GO:0006839|GO:0030162|GO:0008637|GO:0045862|GO:2001236|GO:0043525|GO:0072655|GO:1902237|GO:0052547|GO:2001238|GO:0010822|GO:0010917|GO:0010906|GO:0097345|GO:0051603|GO:0090200|GO:1902108|GO:0035794|GO:0010821|GO:0008630|GO:1901796|GO:0001836|GO:0042981|GO:0051402|GO:0010165|GO:0010952|GO:0097191|GO:0006915|GO:0043516|GO:0010907|GO:0036294|GO:0072332|GO:0010950|GO:1902043|GO:0043281|GO:0042771|GO:0006006|GO:1902110|GO:0031638|GO:0043280|GO:0006919|GO:0030330|GO:0008625|GO:0070585|GO:1902041|GO:0052548|GO:2001056|GO:2000116|GO:0097202 immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|leukocyte homeostasis|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|outer membrane|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|intracellular|positive regulation of cellular protein localization|protein binding|organelle membrane|regulation of metabolic process|regulation of cellular localization|cellular carbohydrate metabolic process|regulation of cell proliferation|regulation of membrane potential|response to radiation|transport|positive regulation of cellular component organization|positive regulation of response to DNA damage stimulus|regulation of cell death|response to extracellular stimulus|small molecule metabolic process|defense response|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|positive regulation of cell death|defense response to other organism|intracellular membrane-bounded organelle|fibroblast proliferation|cytoplasm|cellular response to extracellular stimulus|regulation of protein localization|carbohydrate metabolic process|homeostatic process|reactive oxygen species metabolic process|response to virus|regulation of signal transduction|mitochondrial membrane|establishment of protein localization|positive regulation of intracellular transport|regulation of cell communication|positive regulation of catalytic activity|protein localization|cell communication|membrane organization|signal transduction|lymphocyte homeostasis|regulation of membrane permeability|establishment of localization in cell|cell death|negative regulation of cell proliferation|response to hypoxia|defense response to virus|regulation of catalytic activity|protein insertion into mitochondrial membrane|positive regulation of signal transduction|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|regulation of cellular metabolic process|response to starvation|organelle organization|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|mitochondrial envelope|negative regulation of membrane potential|regulation of carbohydrate metabolic process|cytosol|establishment of protein localization to membrane|cell surface receptor signaling pathway|establishment of protein localization to organelle|protein catabolic process|positive regulation of hydrolase activity|mitochondrion organization|mitochondrial outer membrane|regulation of intracellular transport|positive regulation of neuron death|neuron death|protein maturation|positive regulation of protein oligomerization|cellular macromolecule catabolic process|regulation of mitochondrial membrane permeability|response to dsRNA|cellular response to hypoxia|regulation of establishment of protein localization|intracellular transport|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|homeostasis of number of cells|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|positive regulation of DNA damage response, signal transduction by p53 class mediator|regulation of fibroblast proliferation|T cell homeostasis|regulation of protein oligomerization|protein localization to membrane|regulation of response to DNA damage stimulus|protein insertion into membrane|monosaccharide metabolic process|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of protein metabolic process|proteolysis|mitochondrion|cellular response to starvation|protein complex assembly|regulation of neuron death|regulation of mitochondrial membrane potential|cellular response to oxygen levels|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|response to ionizing radiation|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|gene expression|negative regulation of fibroblast proliferation|regulation of protein metabolic process|positive regulation of programmed cell death|cellular response to nutrient levels|regulation of cellular protein localization|regulation of intracellular signal transduction|response to nutrient levels|response to endoplasmic reticulum stress|nucleus|response to light stimulus|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|mitochondrial membrane organization|positive regulation of organelle organization|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|hexose metabolic process|cellular protein catabolic process|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|protein localization to organelle|positive regulation of signal transduction by p53 class mediator|cellular response to glucose starvation|positive regulation of apoptotic process|response to UV|proteasomal protein catabolic process|positive regulation of intrinsic apoptotic signaling pathway|protein oligomerization|protein processing|regulation of neuron apoptotic process|signal transduction by p53 class mediator|signal transduction in response to DNA damage|mitochondrial transport|regulation of proteolysis|apoptotic mitochondrial changes|positive regulation of proteolysis|regulation of extrinsic apoptotic signaling pathway|positive regulation of neuron apoptotic process|establishment of protein localization to mitochondrion|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|regulation of peptidase activity|positive regulation of extrinsic apoptotic signaling pathway|positive regulation of mitochondrion organization|negative regulation of mitochondrial membrane potential|regulation of glucose metabolic process|mitochondrial outer membrane permeabilization|proteolysis involved in cellular protein catabolic process|positive regulation of release of cytochrome c from mitochondria|regulation of mitochondrial membrane permeability involved in apoptotic process|positive regulation of mitochondrial membrane permeability|regulation of mitochondrion organization|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of signal transduction by p53 class mediator|release of cytochrome c from mitochondria|regulation of apoptotic process|neuron apoptotic process|response to X-ray|positive regulation of peptidase activity|extrinsic apoptotic signaling pathway|apoptotic process|regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of glucose metabolic process|cellular response to decreased oxygen levels|intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of endopeptidase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of cysteine-type endopeptidase activity involved in apoptotic process|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|glucose metabolic process|positive regulation of mitochondrial membrane permeability involved in apoptotic process|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|DNA damage response, signal transduction by p53 class mediator|extrinsic apoptotic signaling pathway via death domain receptors|protein localization to mitochondrion|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity K10131 phorbol-12-myristate-13-acetate-induced protein 1[-] hsa05203|hsa04210|hsa04115 Viral carcinogenesis - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 18:59899948-59904306 1266 1258 1299 399 545 540 22.3101308251514 20.1478693856754 20.6391430548666 6.29997374047445 7.88011971013273 8.91848918186185 21.0323810885645 7.69952754415634 1.44977036022873 5.62278155957719e-13 2.06982146337383e-11 UP ENSG00000254929 RP11-144G6.12 - - - - - - - 10:47517816-47553514 2 0 1 34 26 50 0.0801967833879422 0 0.0361364386733812 1.22159006259656 0.855444774577606 1.87908751099111 0.0387777406871078 1.31870744938843 -5.0877519830861 5.70899931231891e-13 2.09897124963016e-11 DOWN ENSG00000159873 CCDC117 coiled-coil domain containing 117 [Source:HGNC Symbol;Acc:HGNC:26599] GO:0005488|GO:0005515 binding|protein binding - - - - 22:28772674-28789301 2357 2739 2184 938 1060 862 19.798930475041 20.9100027748695 16.5405131397364 7.05964280734325 7.30560025922706 6.78607115831065 19.083148796549 7.05043807496032 1.43651443504302 6.14068166649324e-13 2.2549066478658e-11 UP ENSG00000197594 ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:3356] GO:0032502|GO:0040007|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0004872|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009986|GO:0051051|GO:0044237|GO:0023051|GO:0045926|GO:0016043|GO:0030246|GO:0043227|GO:0071944|GO:0040008|GO:0023057|GO:0016787|GO:0009058|GO:0031224|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0044262|GO:0045595|GO:0006725|GO:0009888|GO:0016323|GO:0006810|GO:1901360|GO:0006082|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0005102|GO:0034641|GO:0043168|GO:0015980|GO:0016788|GO:0044281|GO:0001882|GO:0019637|GO:0046483|GO:0051128|GO:0016817|GO:1900076|GO:0005887|GO:0043231|GO:0043169|GO:0010243|GO:0005774|GO:0030308|GO:0005737|GO:0005975|GO:0032403|GO:0042592|GO:0006771|GO:0009966|GO:0046983|GO:0009890|GO:0019725|GO:0010646|GO:0006139|GO:0031226|GO:0055086|GO:0007154|GO:0007165|GO:0030278|GO:0009968|GO:0001503|GO:0009725|GO:0030247|GO:0019915|GO:0050656|GO:0010829|GO:0000166|GO:0006091|GO:0048869|GO:0016021|GO:0044249|GO:0010876|GO:0019538|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0038024|GO:0006790|GO:0055114|GO:0016192|GO:0032268|GO:0006109|GO:0005976|GO:0034645|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0019693|GO:0048878|GO:0050427|GO:0001883|GO:1901652|GO:0031214|GO:0005773|GO:0071417|GO:0016818|GO:0036211|GO:0045599|GO:0032269|GO:0009116|GO:0006811|GO:0032549|GO:0055082|GO:0005158|GO:0033692|GO:0004518|GO:0043434|GO:0005977|GO:0005996|GO:0006112|GO:0043467|GO:0006796|GO:0030730|GO:0044267|GO:0051174|GO:0071310|GO:0017076|GO:0045598|GO:0046627|GO:0019439|GO:0051246|GO:0009059|GO:0030154|GO:0046626|GO:0008643|GO:0046325|GO:0046434|GO:0032870|GO:0016051|GO:0042803|GO:0030282|GO:0042578|GO:0005044|GO:0030500|GO:0010827|GO:0006766|GO:0005978|GO:0019318|GO:0006820|GO:0045444|GO:0008081|GO:0009259|GO:1901653|GO:0000323|GO:0000271|GO:0009117|GO:0005524|GO:0009143|GO:0030554|GO:0046324|GO:0016310|GO:0005509|GO:0004527|GO:0010906|GO:0007167|GO:0071375|GO:0006163|GO:0046914|GO:0050801|GO:0045719|GO:0032868|GO:0090305|GO:0006897|GO:0006464|GO:0006767|GO:0070873|GO:0016462|GO:0042278|GO:0005765|GO:0006873|GO:0004528|GO:0005979|GO:0008645|GO:0047429|GO:0005764|GO:0006468|GO:0006006|GO:0042325|GO:0001932|GO:0055081|GO:0032869|GO:0042326|GO:0006898|GO:0004551|GO:0001933|GO:0015698|GO:0008270|GO:0007169|GO:0035529|GO:0015758|GO:0046777|GO:0031952|GO:0031953|GO:0030505|GO:0008286|GO:0046323|GO:0030643|GO:0055062 developmental process|growth|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|catabolic process|ion binding|immune response|cell surface|negative regulation of transport|cellular metabolic process|regulation of signaling|negative regulation of growth|cellular component organization|carbohydrate binding|membrane-bounded organelle|cell periphery|regulation of growth|negative regulation of signaling|hydrolase activity|biosynthetic process|intrinsic component of membrane|extracellular space|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|cellular carbohydrate metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|basolateral plasma membrane|transport|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|receptor binding|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|hydrolase activity, acting on ester bonds|small molecule metabolic process|nucleoside binding|organophosphate metabolic process|heterocycle metabolic process|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|regulation of cellular response to insulin stimulus|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|vacuolar membrane|negative regulation of cell growth|cytoplasm|carbohydrate metabolic process|protein complex binding|homeostatic process|riboflavin metabolic process|regulation of signal transduction|protein dimerization activity|negative regulation of biosynthetic process|cellular homeostasis|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|regulation of ossification|negative regulation of signal transduction|ossification|response to hormone|polysaccharide binding|lipid storage|3'-phosphoadenosine 5'-phosphosulfate binding|negative regulation of glucose transport|nucleotide binding|generation of precursor metabolites and energy|cellular developmental process|integral component of membrane|cellular biosynthetic process|lipid localization|protein metabolic process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cargo receptor activity|sulfur compound metabolic process|oxidation-reduction process|vesicle-mediated transport|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|polysaccharide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|ribose phosphate metabolic process|chemical homeostasis|3'-phosphoadenosine 5'-phosphosulfate metabolic process|purine nucleoside binding|response to peptide|biomineral tissue development|vacuole|cellular response to organonitrogen compound|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|negative regulation of fat cell differentiation|negative regulation of cellular protein metabolic process|nucleoside metabolic process|ion transport|ribonucleoside binding|cellular chemical homeostasis|insulin receptor binding|cellular polysaccharide biosynthetic process|nuclease activity|response to peptide hormone|glycogen metabolic process|monosaccharide metabolic process|energy reserve metabolic process|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|sequestering of triglyceride|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|purine nucleotide binding|regulation of fat cell differentiation|negative regulation of insulin receptor signaling pathway|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|regulation of insulin receptor signaling pathway|carbohydrate transport|negative regulation of glucose import|organophosphate catabolic process|cellular response to hormone stimulus|carbohydrate biosynthetic process|protein homodimerization activity|bone mineralization|phosphoric ester hydrolase activity|scavenger receptor activity|regulation of bone mineralization|regulation of glucose transport|vitamin metabolic process|glycogen biosynthetic process|hexose metabolic process|anion transport|fat cell differentiation|phosphoric diester hydrolase activity|ribonucleotide metabolic process|cellular response to peptide|lytic vacuole|polysaccharide biosynthetic process|nucleotide metabolic process|ATP binding|nucleoside triphosphate catabolic process|adenyl nucleotide binding|regulation of glucose import|phosphorylation|calcium ion binding|exonuclease activity|regulation of glucose metabolic process|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|purine nucleotide metabolic process|transition metal ion binding|ion homeostasis|negative regulation of glycogen biosynthetic process|response to insulin|nucleic acid phosphodiester bond hydrolysis|endocytosis|cellular protein modification process|water-soluble vitamin metabolic process|regulation of glycogen metabolic process|pyrophosphatase activity|purine nucleoside metabolic process|lysosomal membrane|cellular ion homeostasis|phosphodiesterase I activity|regulation of glycogen biosynthetic process|hexose transport|nucleoside-triphosphate diphosphatase activity|lysosome|protein phosphorylation|glucose metabolic process|regulation of phosphorylation|regulation of protein phosphorylation|anion homeostasis|cellular response to insulin stimulus|negative regulation of phosphorylation|receptor-mediated endocytosis|nucleotide diphosphatase activity|negative regulation of protein phosphorylation|inorganic anion transport|zinc ion binding|transmembrane receptor protein tyrosine kinase signaling pathway|NADH pyrophosphatase activity|glucose transport|protein autophosphorylation|regulation of protein autophosphorylation|negative regulation of protein autophosphorylation|inorganic diphosphate transport|insulin receptor signaling pathway|glucose import|cellular phosphate ion homeostasis|phosphate ion homeostasis K01513 ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3[3.6.1.9] hsa01100|hsa00230|hsa00500 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human) 6:131808016-131895155 4 4 7 41 57 56 0.0297888241516804 0.0270740375148745 0.0470007359233655 0.273585889614883 0.348299740849101 0.390871273784484 0.0346211991966401 0.337585634749489 -3.2855259122473 6.32737959779343e-13 2.32060922005559e-11 DOWN ENSG00000241360 PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase [Source:HGNC Symbol;Acc:HGNC:30259] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0030496|GO:0051716|GO:0042995|GO:0050794|GO:0070938|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0009986|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0006081|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:0051130|GO:1901360|GO:0051302|GO:0032535|GO:0034641|GO:0016788|GO:0031982|GO:0019637|GO:0046483|GO:0051128|GO:0022607|GO:0043169|GO:0010243|GO:0005737|GO:0032970|GO:0001726|GO:0030027|GO:0051186|GO:0070062|GO:0031256|GO:0031072|GO:0031253|GO:0051301|GO:0030029|GO:0019538|GO:0010033|GO:0032154|GO:0006996|GO:0051017|GO:0005829|GO:0046872|GO:0032956|GO:0014074|GO:0031258|GO:1903047|GO:0043412|GO:0007010|GO:0046683|GO:0071417|GO:0036211|GO:0000278|GO:0032465|GO:0007346|GO:0010564|GO:0033198|GO:0043244|GO:0030036|GO:0032587|GO:0014070|GO:0006796|GO:0033043|GO:0044267|GO:0007067|GO:0071310|GO:0019439|GO:0030832|GO:0043243|GO:0046434|GO:0005856|GO:0000910|GO:0042578|GO:0046185|GO:0010638|GO:0015629|GO:0043241|GO:0031247|GO:0016311|GO:0000287|GO:0007088|GO:1901881|GO:0071318|GO:0071407|GO:0008064|GO:0051493|GO:1901879|GO:0016791|GO:0006464|GO:0007015|GO:0051495|GO:0032361|GO:0006470|GO:0030836|GO:0043624|GO:0004647|GO:0004721|GO:0033883|GO:0030834|GO:0061572|GO:0008154|GO:0030042|GO:0051261 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|midbody|cellular response to stimulus|cell projection|regulation of cellular process|contractile ring|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cell surface|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|intracellular|protein binding|plasma membrane|cellular aldehyde metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell division|regulation of cellular component size|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|vesicle|organophosphate metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|cation binding|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|ruffle|lamellipodium|cofactor metabolic process|extracellular exosome|leading edge membrane|heat shock protein binding|cell projection membrane|cell division|actin filament-based process|protein metabolic process|response to organic substance|cleavage furrow|organelle organization|actin filament bundle assembly|cytosol|metal ion binding|regulation of actin cytoskeleton organization|response to purine-containing compound|lamellipodium membrane|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|response to organophosphorus|cellular response to organonitrogen compound|protein modification process|mitotic cell cycle|regulation of cytokinesis|regulation of mitotic cell cycle|regulation of cell cycle process|response to ATP|regulation of protein complex disassembly|actin cytoskeleton organization|ruffle membrane|response to organic cyclic compound|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|mitotic nuclear division|cellular response to organic substance|aromatic compound catabolic process|regulation of actin filament length|positive regulation of protein complex disassembly|organophosphate catabolic process|cytoskeleton|cytokinesis|phosphoric ester hydrolase activity|aldehyde catabolic process|positive regulation of organelle organization|actin cytoskeleton|protein complex disassembly|actin rod assembly|dephosphorylation|magnesium ion binding|regulation of mitotic nuclear division|positive regulation of protein depolymerization|cellular response to ATP|cellular response to organic cyclic compound|regulation of actin polymerization or depolymerization|regulation of cytoskeleton organization|regulation of protein depolymerization|phosphatase activity|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|pyridoxal phosphate catabolic process|protein dephosphorylation|positive regulation of actin filament depolymerization|cellular protein complex disassembly|phosphoserine phosphatase activity|phosphoprotein phosphatase activity|pyridoxal phosphatase activity|regulation of actin filament depolymerization|actin filament bundle organization|actin polymerization or depolymerization|actin filament depolymerization|protein depolymerization K07758 pyridoxal phosphatase[3.1.3.74] hsa01100|hsa00750 Metabolic pathways - Homo sapiens (human)|Vitamin B6 metabolism - Homo sapiens (human) 22:37658727-37666934 1173 1295 1099 455 534 349 23.1707192414711 23.2482958576846 19.5728130591065 8.05286068244152 8.65467624121462 6.46093725875177 21.9972760527541 7.7228247274693 1.51012434993944 6.53717416067819e-13 2.39461101095566e-11 UP ENSG00000008277 ADAM22 ADAM metallopeptidase domain 22 [Source:HGNC Symbol;Acc:HGNC:201] GO:0032502|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0042995|GO:0048523|GO:0044877|GO:0050794|GO:0071704|GO:0043167|GO:0007155|GO:0044708|GO:0071944|GO:0016787|GO:0031224|GO:0005515|GO:0005886|GO:0007626|GO:0048856|GO:0008344|GO:0048468|GO:0030534|GO:0007275|GO:0005102|GO:0030155|GO:0043169|GO:0008233|GO:0032403|GO:0043005|GO:0050839|GO:0007162|GO:0048869|GO:0016021|GO:0019538|GO:0046872|GO:0030424|GO:0007417|GO:0021782|GO:0005178|GO:0006508|GO:0007399|GO:0030154|GO:0008366|GO:0007422|GO:0008237|GO:0014044|GO:0010001|GO:0004175|GO:0046914|GO:0042552|GO:0022008|GO:0014037|GO:0022011|GO:0042063|GO:0008270|GO:0004222 developmental process|behavior|cell|membrane|cellular process|metabolic process|binding|catalytic activity|cell projection|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|organic substance metabolic process|ion binding|cell adhesion|single-organism behavior|cell periphery|hydrolase activity|intrinsic component of membrane|protein binding|plasma membrane|locomotory behavior|anatomical structure development|adult locomotory behavior|cell development|adult behavior|multicellular organism development|receptor binding|regulation of cell adhesion|cation binding|peptidase activity|protein complex binding|neuron projection|cell adhesion molecule binding|negative regulation of cell adhesion|cellular developmental process|integral component of membrane|protein metabolic process|metal ion binding|axon|central nervous system development|glial cell development|integrin binding|proteolysis|nervous system development|cell differentiation|axon ensheathment|peripheral nervous system development|metallopeptidase activity|Schwann cell development|glial cell differentiation|endopeptidase activity|transition metal ion binding|myelination|neurogenesis|Schwann cell differentiation|myelination in peripheral nervous system|gliogenesis|zinc ion binding|metalloendopeptidase activity - - - - 7:87934143-88202889 66 85 168 471 488 703 0.319352482209836 0.37379103231266 0.732912356661394 2.04195825607309 1.937386249257 3.18795621388735 0.475351957061297 2.38910023973915 -2.32939938112239 6.56960214943926e-13 2.40354047266372e-11 DOWN ENSG00000163689 C3orf67 chromosome 3 open reading frame 67 [Source:HGNC Symbol;Acc:HGNC:24763] - - - - - - 3:58717365-59050084 6 7 7 57 54 62 0.0303642682756665 0.0321987221300248 0.0319391135293787 0.258468370986013 0.224231058061785 0.29406953070554 0.03150070131169 0.258922986584446 -3.03906719672305 6.66994471584813e-13 2.43726474353648e-11 DOWN ENSG00000135549 PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta [Source:HGNC Symbol;Acc:HGNC:9018] GO:0005623|GO:0009987|GO:0008152|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0030234|GO:0005622|GO:0019222|GO:0051726|GO:0007049|GO:0004857|GO:0006725|GO:0051130|GO:1901360|GO:0034641|GO:0032204|GO:0031325|GO:0046483|GO:0051128|GO:0032206|GO:0043231|GO:0000723|GO:0005737|GO:0042592|GO:0006139|GO:0043085|GO:0044092|GO:0050790|GO:0019207|GO:0043086|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0007004|GO:0019210|GO:0034645|GO:0010833|GO:0043412|GO:0019887|GO:0051347|GO:0036211|GO:0032269|GO:1904358|GO:0006259|GO:0051054|GO:0006796|GO:0033043|GO:0044267|GO:0051174|GO:0031328|GO:1904355|GO:0051246|GO:1904356|GO:0009059|GO:0016233|GO:0010557|GO:0005634|GO:0010638|GO:2001252|GO:0032200|GO:0006260|GO:0051972|GO:0051973|GO:0016310|GO:0033044|GO:1904030|GO:0032212|GO:2000278|GO:0004860|GO:0006275|GO:0033673|GO:2000573|GO:0045740|GO:0006464|GO:0071897|GO:0032210|GO:0043549|GO:0030291|GO:0006278|GO:0045859|GO:0006469|GO:0006468|GO:0042325|GO:0001932|GO:0042326|GO:0001933|GO:0071901|GO:0071900|GO:0004862|GO:2000480|GO:2000479 cell|cellular process|metabolic process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|intracellular|regulation of metabolic process|regulation of cell cycle|cell cycle|enzyme inhibitor activity|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|regulation of telomere maintenance|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of telomere maintenance|intracellular membrane-bounded organelle|telomere maintenance|cytoplasm|homeostatic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|negative regulation of molecular function|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|telomere maintenance via telomerase|kinase inhibitor activity|cellular macromolecule biosynthetic process|telomere maintenance via telomere lengthening|macromolecule modification|protein kinase regulator activity|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|positive regulation of telomere maintenance via telomere lengthening|DNA metabolic process|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of cellular biosynthetic process|positive regulation of telomere capping|regulation of protein metabolic process|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|telomere capping|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of organelle organization|positive regulation of chromosome organization|telomere organization|DNA replication|regulation of telomerase activity|positive regulation of telomerase activity|phosphorylation|regulation of chromosome organization|negative regulation of cyclin-dependent protein kinase activity|positive regulation of telomere maintenance via telomerase|regulation of DNA biosynthetic process|protein kinase inhibitor activity|regulation of DNA replication|negative regulation of kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|cellular protein modification process|DNA biosynthetic process|regulation of telomere maintenance via telomerase|regulation of kinase activity|protein serine/threonine kinase inhibitor activity|RNA-dependent DNA replication|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|cAMP-dependent protein kinase inhibitor activity|negative regulation of cAMP-dependent protein kinase activity|regulation of cAMP-dependent protein kinase activity - - - - 6:122471917-122726373 69 54 101 301 385 308 0.66388027159202 0.472186386326136 0.876144774317699 2.59479915579853 3.03926747497997 2.77727804398145 0.670737144078618 2.80378155825332 -2.06355455086897 6.7013937346947e-13 2.44576294077721e-11 DOWN ENSG00000102096 PIM2 Pim-2 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8987] GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0006914|GO:0023051|GO:0016043|GO:0051707|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0051726|GO:0042127|GO:0007049|GO:0010506|GO:0006725|GO:0022402|GO:1901360|GO:0010941|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0005737|GO:0010508|GO:0009615|GO:0009966|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0007126|GO:0031647|GO:0008219|GO:0008285|GO:0000166|GO:0009967|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:1902533|GO:0010468|GO:0034645|GO:0035639|GO:1903047|GO:0043412|GO:0050821|GO:0043069|GO:0051252|GO:0001883|GO:0044770|GO:0010628|GO:0036211|GO:0000278|GO:0032549|GO:0007140|GO:0007346|GO:0016301|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0010467|GO:0017076|GO:0031328|GO:0009059|GO:1902531|GO:0016070|GO:0016773|GO:0010557|GO:0043067|GO:0045893|GO:0043122|GO:0032774|GO:0005524|GO:0044772|GO:2001141|GO:0030554|GO:0016310|GO:0043123|GO:0007249|GO:0042981|GO:0043066|GO:0004672|GO:0006464|GO:0006351|GO:0006915|GO:0006355|GO:0006468|GO:1903506|GO:0000082|GO:0004674|GO:0046777 reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|autophagy|regulation of signaling|cellular component organization|response to other organism|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of autophagy|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cytoplasm|positive regulation of autophagy|response to virus|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|meiotic nuclear division|regulation of protein stability|cell death|negative regulation of cell proliferation|nucleotide binding|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|positive regulation of intracellular signal transduction|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|protein stabilization|negative regulation of programmed cell death|regulation of RNA metabolic process|purine nucleoside binding|cell cycle phase transition|positive regulation of gene expression|protein modification process|mitotic cell cycle|ribonucleoside binding|male meiosis|regulation of mitotic cell cycle|kinase activity|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|positive regulation of transcription, DNA-templated|regulation of I-kappaB kinase/NF-kappaB signaling|RNA biosynthetic process|ATP binding|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|cellular protein modification process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|protein phosphorylation|regulation of nucleic acid-templated transcription|G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|protein autophosphorylation K08806 proto-oncogene serine/threonine-protein kinase Pim-2[2.7.11.1] hsa05221 Acute myeloid leukemia - Homo sapiens (human) X:48913182-48919024 159 179 239 53 59 52 3.05794819626835 3.12872688874696 4.14425973661473 0.913292281360569 0.931016148383214 0.93727076132239 3.44364494054335 0.927193063688724 1.89299472157922 6.73661526529196e-13 2.45561553272315e-11 UP ENSG00000254901 BORCS8 BLOC-1 related complex subunit 8 [Source:HGNC Symbol;Acc:HGNC:37247] GO:0032502|GO:0005488|GO:0005515|GO:0048856|GO:0007507|GO:0007275|GO:0048513|GO:0072358|GO:0072359 developmental process|binding|protein binding|anatomical structure development|heart development|multicellular organism development|animal organ development|cardiovascular system development|circulatory system development - - - - 19:19176903-19192591 31 26 28 138 173 129 0.208921478926873 0.159248271156232 0.17013326100936 0.833292403647386 0.956610067732753 0.81477885908743 0.179434337030822 0.868227110155856 -2.27461647642825 6.84499849493431e-13 2.4920803057045e-11 DOWN ENSG00000142677 IL22RA1 interleukin 22 receptor subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:13700] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0006950|GO:0038023|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0006952|GO:0098542|GO:0004888|GO:0009617|GO:0007154|GO:0007165|GO:0019955|GO:0016021|GO:0010033|GO:0007166|GO:0004896|GO:0034097|GO:0042015|GO:0071310|GO:0042742|GO:0004904|GO:0019221|GO:0071345|GO:0050829 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|response to stress|signaling receptor activity|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|defense response|defense response to other organism|transmembrane signaling receptor activity|response to bacterium|cell communication|signal transduction|cytokine binding|integral component of membrane|response to organic substance|cell surface receptor signaling pathway|cytokine receptor activity|response to cytokine|interleukin-20 binding|cellular response to organic substance|defense response to bacterium|interferon receptor activity|cytokine-mediated signaling pathway|cellular response to cytokine stimulus|defense response to Gram-negative bacterium K05138 interleukin 22 receptor alpha 1[-] hsa04060|hsa04630 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human) 1:24119771-24143121 1 8 11 56 73 72 0.0252918847114417 0.183809298296124 0.250723801925296 1.26847730863426 1.51422939665504 1.70591057941348 0.153274994977621 1.49620576156759 -3.28711432903626 6.97168033173596e-13 2.53511016593965e-11 DOWN ENSG00000164953 TMEM67 transmembrane protein 67 [Source:HGNC Symbol;Acc:HGNC:28396] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0005929|GO:0048646|GO:0031090|GO:0051726|GO:0007049|GO:0022402|GO:0060170|GO:0031982|GO:0051128|GO:0033554|GO:0022607|GO:0045786|GO:0043231|GO:0005737|GO:0032886|GO:0012506|GO:0072372|GO:0036038|GO:0005783|GO:0035869|GO:0051082|GO:0008092|GO:0030030|GO:0031253|GO:0048869|GO:0016021|GO:0007017|GO:0019538|GO:0010033|GO:0036503|GO:0006996|GO:0031023|GO:0000902|GO:0005813|GO:0031005|GO:0007010|GO:0030163|GO:0031410|GO:0070507|GO:0005815|GO:0007098|GO:0044265|GO:0016023|GO:0044782|GO:0030433|GO:0030031|GO:0010564|GO:0006508|GO:0031988|GO:0070925|GO:0042384|GO:0030659|GO:0033043|GO:0044267|GO:0051298|GO:0032990|GO:0048858|GO:0000226|GO:0034976|GO:0005856|GO:0031513|GO:0010948|GO:0060271|GO:0044257|GO:0010498|GO:0010826|GO:0051494|GO:0051493|GO:0051603|GO:0015630|GO:0051297|GO:0010824|GO:0046605|GO:0019941|GO:0043161|GO:0006511 developmental process|macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of cell cycle|cell cycle|cell cycle process|ciliary membrane|vesicle|regulation of cellular component organization|cellular response to stress|cellular component assembly|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|regulation of microtubule-based process|vesicle membrane|primary cilium|TCTN-B9D complex|endoplasmic reticulum|ciliary transition zone|unfolded protein binding|cytoskeletal protein binding|cell projection organization|cell projection membrane|cellular developmental process|integral component of membrane|microtubule-based process|protein metabolic process|response to organic substance|ERAD pathway|organelle organization|microtubule organizing center organization|cell morphogenesis|centrosome|filamin binding|cytoskeleton organization|protein catabolic process|cytoplasmic vesicle|regulation of microtubule cytoskeleton organization|microtubule organizing center|centrosome cycle|cellular macromolecule catabolic process|cytoplasmic, membrane-bounded vesicle|cilium organization|ER-associated ubiquitin-dependent protein catabolic process|cell projection assembly|regulation of cell cycle process|proteolysis|membrane-bounded vesicle|organelle assembly|cilium assembly|cytoplasmic vesicle membrane|regulation of organelle organization|cellular protein metabolic process|centrosome duplication|cell part morphogenesis|cell projection morphogenesis|microtubule cytoskeleton organization|response to endoplasmic reticulum stress|cytoskeleton|nonmotile primary cilium|negative regulation of cell cycle process|cilium morphogenesis|cellular protein catabolic process|proteasomal protein catabolic process|negative regulation of centrosome duplication|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|centrosome organization|regulation of centrosome duplication|regulation of centrosome cycle|modification-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process - - - - 8:93754844-93819234 87 104 119 340 397 409 0.481128774197514 0.522701854133627 0.593340733072048 1.68468333875313 1.80135740757723 2.11979162407208 0.532390453801063 1.86861079013415 -1.81140949591312 6.98687330374002e-13 2.53754398552134e-11 DOWN ENSG00000170128 GPR25 G protein-coupled receptor 25 [Source:HGNC Symbol;Acc:HGNC:4480] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0005887|GO:0004888|GO:0031226|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0004930 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|integral component of plasma membrane|transmembrane signaling receptor activity|intrinsic component of plasma membrane|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor activity - - - - 1:200873038-200874123 48 32 20 0 0 2 3.126467351206 1.89428514413464 1.17454976052879 0 0 0.1220731959074 2.06510075195648 0.0406910653024667 5.66535630818696 7.73622320933939e-13 2.80628441909621e-11 UP ENSG00000148737 TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) [Source:HGNC Symbol;Acc:HGNC:11641] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0042445|GO:0023051|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0032993|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0060341|GO:0051726|GO:0042127|GO:0007049|GO:0045595|GO:0006725|GO:0046887|GO:0009888|GO:0008013|GO:0048468|GO:0010718|GO:0006810|GO:0022402|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0006082|GO:0043570|GO:0007275|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0044281|GO:0032940|GO:0031325|GO:0046483|GO:0051128|GO:0032350|GO:0051098|GO:0061061|GO:0045786|GO:0045597|GO:0043231|GO:0019899|GO:0005737|GO:0007267|GO:0032880|GO:0051222|GO:0005667|GO:0042592|GO:0009966|GO:0045184|GO:0009890|GO:0046883|GO:0019904|GO:0060548|GO:0032388|GO:0010646|GO:0006139|GO:0000790|GO:0008104|GO:0007154|GO:0044092|GO:0007165|GO:0071664|GO:0009968|GO:0051649|GO:0008134|GO:0008219|GO:0090316|GO:0031016|GO:0051047|GO:0010817|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0006790|GO:0051090|GO:0045295|GO:0051276|GO:1902533|GO:0030111|GO:0000902|GO:0003677|GO:0009743|GO:0044334|GO:0010468|GO:0034645|GO:0048660|GO:0030178|GO:0007166|GO:0090276|GO:2000736|GO:0002793|GO:0044798|GO:0001944|GO:0072358|GO:0015012|GO:0001085|GO:1903020|GO:0010629|GO:0010720|GO:0051427|GO:0042692|GO:0043069|GO:2001234|GO:0048878|GO:0051252|GO:0032386|GO:0070491|GO:0010717|GO:0051223|GO:0015031|GO:0048659|GO:0007050|GO:0000904|GO:0010628|GO:0009100|GO:0070201|GO:0046907|GO:0042886|GO:0050714|GO:0051046|GO:0060485|GO:0031981|GO:0046827|GO:0030201|GO:0009914|GO:0070369|GO:0009306|GO:0051099|GO:0051247|GO:0005654|GO:0022604|GO:0006259|GO:0043433|GO:0005694|GO:0000228|GO:0034613|GO:0019900|GO:0012501|GO:0035556|GO:1901137|GO:0048864|GO:0010467|GO:0046903|GO:0031328|GO:0051246|GO:0010770|GO:0009059|GO:0030154|GO:1903827|GO:1902531|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0043067|GO:0070016|GO:0045165|GO:0097190|GO:2000738|GO:0090277|GO:0043393|GO:0050796|GO:2001237|GO:0002790|GO:0051896|GO:0010909|GO:0016055|GO:0043491|GO:0000975|GO:0009101|GO:0045893|GO:0048863|GO:0030073|GO:0010560|GO:0045444|GO:0033157|GO:0090090|GO:0045445|GO:0051169|GO:0010769|GO:0060828|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0035257|GO:0014031|GO:0034284|GO:2001236|GO:0050708|GO:0051897|GO:0015833|GO:0006611|GO:1902679|GO:0016604|GO:0003690|GO:0016482|GO:0006886|GO:0032092|GO:0032024|GO:0042981|GO:0010559|GO:0006029|GO:0043066|GO:0001103|GO:0048762|GO:0090575|GO:0019901|GO:0001837|GO:0097191|GO:0046879|GO:0006351|GO:0006915|GO:0006355|GO:0033500|GO:0048625|GO:0046824|GO:0042593|GO:0045944|GO:0006366|GO:0030072|GO:0006913|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0046825|GO:0060070|GO:0016605|GO:0000122|GO:0030166|GO:1990907|GO:0046822|GO:1904036|GO:0097050|GO:2000675|GO:0051168|GO:0000976|GO:0001012|GO:0009749|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|hormone metabolic process|regulation of signaling|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|protein-DNA complex|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|protein complex|anatomical structure development|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of cell differentiation|cellular aromatic compound metabolic process|positive regulation of hormone secretion|tissue development|beta-catenin binding|cell development|positive regulation of epithelial to mesenchymal transition|transport|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|organic acid metabolic process|maintenance of DNA repeat elements|multicellular organism development|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|regulation of hormone metabolic process|regulation of binding|muscle structure development|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|cell-cell signaling|regulation of protein localization|positive regulation of protein transport|transcription factor complex|homeostatic process|regulation of signal transduction|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|protein domain specific binding|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|nuclear chromatin|protein localization|cell communication|negative regulation of molecular function|signal transduction|catenin-TCF7L2 complex|negative regulation of signal transduction|establishment of localization in cell|transcription factor binding|cell death|positive regulation of intracellular protein transport|pancreas development|positive regulation of secretion|regulation of hormone levels|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|sulfur compound metabolic process|regulation of sequence-specific DNA binding transcription factor activity|gamma-catenin binding|chromosome organization|positive regulation of intracellular signal transduction|regulation of Wnt signaling pathway|cell morphogenesis|DNA binding|response to carbohydrate|canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|regulation of peptide hormone secretion|regulation of stem cell differentiation|positive regulation of peptide secretion|nuclear transcription factor complex|vasculature development|cardiovascular system development|heparan sulfate proteoglycan biosynthetic process|RNA polymerase II transcription factor binding|positive regulation of glycoprotein metabolic process|negative regulation of gene expression|positive regulation of cell development|hormone receptor binding|muscle cell differentiation|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|chemical homeostasis|regulation of RNA metabolic process|regulation of intracellular transport|repressing transcription factor binding|regulation of epithelial to mesenchymal transition|regulation of protein transport|protein transport|smooth muscle cell proliferation|cell cycle arrest|cell morphogenesis involved in differentiation|positive regulation of gene expression|glycoprotein metabolic process|regulation of establishment of protein localization|intracellular transport|amide transport|positive regulation of protein secretion|regulation of secretion|mesenchyme development|nuclear lumen|positive regulation of protein export from nucleus|heparan sulfate proteoglycan metabolic process|hormone transport|beta-catenin-TCF7L2 complex|protein secretion|positive regulation of binding|positive regulation of protein metabolic process|nucleoplasm|regulation of cell morphogenesis|DNA metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|chromosome|nuclear chromosome|cellular protein localization|kinase binding|programmed cell death|intracellular signal transduction|carbohydrate derivative biosynthetic process|stem cell development|gene expression|secretion|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|armadillo repeat domain binding|cell fate commitment|apoptotic signaling pathway|positive regulation of stem cell differentiation|positive regulation of peptide hormone secretion|regulation of protein binding|regulation of insulin secretion|negative regulation of extrinsic apoptotic signaling pathway|peptide secretion|regulation of protein kinase B signaling|positive regulation of heparan sulfate proteoglycan biosynthetic process|Wnt signaling pathway|protein kinase B signaling|regulatory region DNA binding|glycoprotein biosynthetic process|positive regulation of transcription, DNA-templated|stem cell differentiation|insulin secretion|positive regulation of glycoprotein biosynthetic process|fat cell differentiation|regulation of intracellular protein transport|negative regulation of canonical Wnt signaling pathway|myoblast differentiation|nuclear transport|regulation of cell morphogenesis involved in differentiation|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nuclear hormone receptor binding|mesenchymal cell development|response to monosaccharide|regulation of extrinsic apoptotic signaling pathway|regulation of protein secretion|positive regulation of protein kinase B signaling|peptide transport|protein export from nucleus|negative regulation of RNA biosynthetic process|nuclear body|double-stranded DNA binding|cytosolic transport|intracellular protein transport|positive regulation of protein binding|positive regulation of insulin secretion|regulation of apoptotic process|regulation of glycoprotein biosynthetic process|proteoglycan metabolic process|negative regulation of apoptotic process|RNA polymerase II repressing transcription factor binding|mesenchymal cell differentiation|RNA polymerase II transcription factor complex|protein kinase binding|epithelial to mesenchymal transition|extrinsic apoptotic signaling pathway|hormone secretion|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|carbohydrate homeostasis|myoblast fate commitment|positive regulation of nucleocytoplasmic transport|glucose homeostasis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of protein export from nucleus|canonical Wnt signaling pathway|PML body|negative regulation of transcription from RNA polymerase II promoter|proteoglycan biosynthetic process|beta-catenin-TCF complex|regulation of nucleocytoplasmic transport|negative regulation of epithelial cell apoptotic process|type B pancreatic cell apoptotic process|negative regulation of type B pancreatic cell apoptotic process|nuclear export|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|response to glucose|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K04491 transcription factor 7-like 2[-] hsa05200|hsa04390|hsa04310|hsa04916|hsa05215|hsa04520|hsa05412|hsa05210|hsa05221|hsa05217|hsa05213|hsa05216 Pathways in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Thyroid cancer - Homo sapiens (human) 10:112950250-113167678 18 30 63 217 240 237 0.100273302411078 0.151883687381642 0.316421259510344 1.08309687581452 1.09695921572724 1.23733628315722 0.189526083101021 1.13913079156633 -2.58746508762173 7.78202159942709e-13 2.81947175763709e-11 DOWN ENSG00000267649 CTD-2587H24.10 - - - - - - - 19:55216660-55221616 69 72 44 9 7 7 3.04102663971622 2.88391635494891 1.74839099034371 0.355386675610897 0.253126622457114 0.28914064448251 2.55777799500295 0.299217980850174 3.09562227089288 7.87649283930549e-13 2.85024020878335e-11 UP ENSG00000026297 RNASET2 ribonuclease T2 [Source:HGNC Symbol;Acc:HGNC:21686] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005615|GO:0005622|GO:0012505|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0005783|GO:0070062|GO:0003723|GO:0044265|GO:0005773|GO:0004518|GO:0005788|GO:0005775|GO:0019439|GO:0016070|GO:0006401|GO:0090501|GO:0000323|GO:0043202|GO:0004519|GO:0004540|GO:0090305|GO:0005764|GO:0090502|GO:0004521|GO:0016892|GO:0033897 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|extracellular space|intracellular|endomembrane system|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|endoplasmic reticulum|extracellular exosome|RNA binding|cellular macromolecule catabolic process|vacuole|nuclease activity|endoplasmic reticulum lumen|vacuolar lumen|aromatic compound catabolic process|RNA metabolic process|RNA catabolic process|RNA phosphodiester bond hydrolysis|lytic vacuole|lysosomal lumen|endonuclease activity|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|lysosome|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|endoribonuclease activity, producing 3'-phosphomonoesters|ribonuclease T2 activity - - - - 6:166929504-166957191 74 96 130 388 367 414 0.370168213136257 0.436431723328666 0.586305531045297 1.73898149174 1.50625990738462 1.94086372301428 0.464301822503407 1.72870170737963 -1.8965541001606 8.22482155584242e-13 2.97268550518305e-11 DOWN ENSG00000138134 STAMBPL1 STAM binding protein like 1 [Source:HGNC Symbol;Acc:HGNC:24105] GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0043167|GO:0016787|GO:0005515|GO:0043169|GO:0008233|GO:0019538|GO:0046872|GO:0006508|GO:0008237 membrane|metabolic process|binding|catalytic activity|organic substance metabolic process|ion binding|hydrolase activity|protein binding|cation binding|peptidase activity|protein metabolic process|metal ion binding|proteolysis|metallopeptidase activity - - - - 10:88879734-88975153 124 154 215 688 682 489 1.19500808872832 1.34880715533743 1.86810818301742 5.94067464231952 5.39264762070054 4.41659665684298 1.47064114236106 5.24997297328768 -1.83586474469497 8.38997357797237e-13 3.02686542853782e-11 DOWN ENSG00000228409 CCT6P1 chaperonin containing TCP1, subunit 6 (zeta) pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:33094] - - - - - - 7:65751142-65763354 178 217 155 51 41 40 4.93384426070277 5.46644787453603 3.87357540762246 1.26658593480819 0.932424038666791 1.03909968607395 4.75795584762042 1.07936988651631 2.14015254101079 8.39500427021276e-13 3.02686542853782e-11 UP ENSG00000181788 SIAH2 siah E3 ubiquitin protein ligase 2 [Source:HGNC Symbol;Acc:HGNC:10858] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0000989|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:0007049|GO:0006935|GO:0003712|GO:0006725|GO:0048468|GO:0043025|GO:1901360|GO:0010941|GO:0007275|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0006928|GO:0043005|GO:0009966|GO:0009890|GO:0036477|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0008219|GO:0019787|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0005768|GO:0032268|GO:0030111|GO:0000902|GO:0005829|GO:0031175|GO:0030178|GO:0003714|GO:0046872|GO:0007166|GO:0043412|GO:0030163|GO:0004842|GO:0005769|GO:0043069|GO:2001234|GO:0051252|GO:0044265|GO:0000904|GO:0036211|GO:0032269|GO:0031981|GO:0051346|GO:0006508|GO:0005654|GO:0012501|GO:0035556|GO:0044267|GO:0044390|GO:0032990|GO:0007399|GO:0097485|GO:0051246|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0005634|GO:0043067|GO:0097190|GO:0048666|GO:0030182|GO:2001237|GO:0007411|GO:0016055|GO:0044257|GO:0010466|GO:0090090|GO:0061630|GO:0010498|GO:0060828|GO:0032774|GO:0030162|GO:2001141|GO:2001236|GO:1902679|GO:0052547|GO:0061564|GO:0051603|GO:0042981|GO:0045861|GO:0046914|GO:0043066|GO:0022008|GO:0031624|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0097191|GO:0006915|GO:1903507|GO:0007409|GO:0043281|GO:0019941|GO:0048699|GO:1903506|GO:0060070|GO:0010951|GO:0043154|GO:0008270|GO:0043161|GO:0052548|GO:0032446|GO:0006511|GO:2000117|GO:0031396|GO:2000116|GO:0042787|GO:0016567 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|biosynthetic process|ligase activity|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|cell cycle|chemotaxis|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|neuronal cell body|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|movement of cell or subcellular component|neuron projection|regulation of signal transduction|negative regulation of biosynthetic process|somatodendritic compartment|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|cell death|ubiquitin-like protein transferase activity|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endosome|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|neuron projection development|negative regulation of Wnt signaling pathway|transcription corepressor activity|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|early endosome|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|cellular macromolecule catabolic process|cell morphogenesis involved in differentiation|protein modification process|negative regulation of cellular protein metabolic process|nuclear lumen|negative regulation of hydrolase activity|proteolysis|nucleoplasm|programmed cell death|intracellular signal transduction|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|cell part morphogenesis|nervous system development|neuron projection guidance|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|nucleus|regulation of programmed cell death|apoptotic signaling pathway|neuron development|neuron differentiation|negative regulation of extrinsic apoptotic signaling pathway|axon guidance|Wnt signaling pathway|cellular protein catabolic process|negative regulation of peptidase activity|negative regulation of canonical Wnt signaling pathway|ubiquitin protein ligase activity|proteasomal protein catabolic process|regulation of canonical Wnt signaling pathway|RNA biosynthetic process|regulation of proteolysis|regulation of RNA biosynthetic process|regulation of extrinsic apoptotic signaling pathway|negative regulation of RNA biosynthetic process|regulation of peptidase activity|axon development|proteolysis involved in cellular protein catabolic process|regulation of apoptotic process|negative regulation of proteolysis|transition metal ion binding|negative regulation of apoptotic process|neurogenesis|ubiquitin conjugating enzyme binding|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|apoptotic process|negative regulation of nucleic acid-templated transcription|axonogenesis|regulation of cysteine-type endopeptidase activity involved in apoptotic process|modification-dependent protein catabolic process|generation of neurons|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|negative regulation of endopeptidase activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of endopeptidase activity|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|negative regulation of cysteine-type endopeptidase activity|regulation of protein ubiquitination|regulation of cysteine-type endopeptidase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - 3:150741127-150763477 1267 1387 1227 490 588 479 26.3909203664992 26.2563543161493 23.0428839738452 9.14475615016381 10.0490032382127 9.35067476169019 25.2300528854979 9.51481138335557 1.40689626773183 8.65625726283045e-13 3.11729679522968e-11 UP ENSG00000181381 DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like [Source:HGNC Symbol;Acc:HGNC:26429] GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043167|GO:0016787|GO:0003676|GO:0043168|GO:0001882|GO:0016817|GO:0000166|GO:0003723|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0017076|GO:0005524|GO:0030554|GO:0016462|GO:0017111|GO:0004386 metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|ion binding|hydrolase activity|nucleic acid binding|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|nucleotide binding|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|purine nucleotide binding|ATP binding|adenyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|helicase activity - - - - 4:168356735-168537786 153 218 276 659 775 764 0.744546786473995 0.96413262611703 1.21094352728514 2.87332163775076 3.0943580659968 3.48435993231376 0.973207646625388 3.15067987868711 -1.69484361749662 8.66835607628783e-13 3.11789279881322e-11 DOWN ENSG00000186409 CCDC30 coiled-coil domain containing 30 [Source:HGNC Symbol;Acc:HGNC:26103] GO:0005576|GO:1903561|GO:0043227|GO:0031982|GO:0070062 extracellular region|extracellular vesicle|membrane-bounded organelle|vesicle|extracellular exosome - - - - 1:42463330-42654664 10 11 13 63 82 94 0.0391550306936978 0.0391470106574943 0.0458943427500917 0.221025929626376 0.263445912798463 0.344956310531964 0.0413987947004279 0.276476050985601 -2.73949384588944 9.00647781452853e-13 3.23561237875974e-11 DOWN ENSG00000100220 RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase [Source:HGNC Symbol;Acc:HGNC:26935] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0044702|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0043227|GO:0016874|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0072669|GO:0001890|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0043231|GO:0048608|GO:0043169|GO:0005737|GO:0005635|GO:0006139|GO:0005783|GO:0008092|GO:0000166|GO:0046872|GO:0003723|GO:0035639|GO:0061458|GO:0001883|GO:0009790|GO:0032549|GO:0031981|GO:0017166|GO:0005654|GO:0010467|GO:0017076|GO:0016070|GO:0005634|GO:0008452|GO:0009792|GO:0006396|GO:0005524|GO:0034660|GO:0030554|GO:0044822|GO:0003972|GO:0006399|GO:0043009|GO:0008380|GO:0008033|GO:0001701|GO:0006388 developmental process|macromolecular complex|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|membrane-bounded organelle|ligase activity|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|anatomical structure development|organelle membrane|tRNA-splicing ligase complex|placenta development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|reproductive structure development|cation binding|cytoplasm|nuclear envelope|nucleobase-containing compound metabolic process|endoplasmic reticulum|cytoskeletal protein binding|nucleotide binding|metal ion binding|RNA binding|purine ribonucleoside triphosphate binding|reproductive system development|purine nucleoside binding|embryo development|ribonucleoside binding|nuclear lumen|vinculin binding|nucleoplasm|gene expression|purine nucleotide binding|RNA metabolic process|nucleus|RNA ligase activity|embryo development ending in birth or egg hatching|RNA processing|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|poly(A) RNA binding|RNA ligase (ATP) activity|tRNA metabolic process|chordate embryonic development|RNA splicing|tRNA processing|in utero embryonic development|tRNA splicing, via endonucleolytic cleavage and ligation - - - - 22:32387582-32412255 342 374 322 1251 1329 906 6.10600832014228 6.06852898205142 5.18324047352646 20.0118086081147 19.4681287043578 15.1596240798853 5.78592592524005 18.2131871307859 -1.65436364373628 9.03070723909016e-13 3.23652741795676e-11 DOWN ENSG00000115761 NOL10 nucleolar protein 10 [Source:HGNC Symbol;Acc:HGNC:25862] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 2:10570766-10689987 237 308 335 973 1121 757 2.64009707395708 3.11818725044935 3.36457953667595 9.71141507788326 10.2457961433897 7.90308429003439 3.04095462036079 9.28676517043578 -1.61065186726432 9.02454510798653e-13 3.23652741795676e-11 DOWN ENSG00000085831 TTC39A tetratricopeptide repeat domain 39A [Source:HGNC Symbol;Acc:HGNC:18657] GO:0005488|GO:0005515 binding|protein binding - - - - 1:51287258-51345116 82 112 159 407 476 581 0.480644448586769 0.596633894005285 0.840278144534253 2.13748271587 2.28920960006799 3.19165426916075 0.639185495708769 2.53944886169958 -1.99020884553779 9.18061248879259e-13 3.28630701727115e-11 DOWN ENSG00000092969 TGFB2 transforming growth factor beta 2 [Source:HGNC Symbol;Acc:HGNC:11768] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0004871|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0002683|GO:0033218|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0001502|GO:0005057|GO:0044702|GO:0071704|GO:0050900|GO:0006955|GO:0009628|GO:0042698|GO:0044237|GO:0051641|GO:0001776|GO:0048870|GO:0023051|GO:0045926|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0043227|GO:0040008|GO:0009605|GO:0009893|GO:0032504|GO:0009058|GO:0005615|GO:0002684|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:0022602|GO:1903829|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0048609|GO:0019222|GO:0042802|GO:0048514|GO:0007507|GO:0060341|GO:0008284|GO:0001818|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:0048565|GO:0003179|GO:0050817|GO:0042277|GO:0006935|GO:0045595|GO:0006725|GO:0061037|GO:0009888|GO:0048468|GO:0045684|GO:0043025|GO:0010718|GO:0006810|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0010632|GO:0048513|GO:0070235|GO:0070237|GO:0051302|GO:0005102|GO:0060325|GO:0030307|GO:0043062|GO:0032940|GO:0030155|GO:0031069|GO:0016772|GO:0031982|GO:0031325|GO:0051128|GO:2000147|GO:0033554|GO:0010942|GO:0001817|GO:0035265|GO:0051098|GO:0030141|GO:0055017|GO:0045786|GO:0045597|GO:0043231|GO:0030308|GO:0001942|GO:0005737|GO:0032970|GO:0001816|GO:0007267|GO:0033627|GO:0009611|GO:0003170|GO:0060322|GO:0007423|GO:0032880|GO:0051222|GO:0071559|GO:0006928|GO:0009887|GO:0042592|GO:0001775|GO:0043005|GO:0009966|GO:0048729|GO:0046983|GO:0048568|GO:0002367|GO:0050673|GO:1903524|GO:0045184|GO:0048771|GO:0036477|GO:0045787|GO:0042637|GO:0042493|GO:0010646|GO:0010171|GO:0043085|GO:0050776|GO:0001525|GO:1900182|GO:0008104|GO:0007154|GO:0044092|GO:0045778|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0030278|GO:0002260|GO:0001503|GO:0051649|GO:0045785|GO:0060323|GO:0004702|GO:0050777|GO:0009725|GO:0008219|GO:0010634|GO:0008285|GO:0001666|GO:0030595|GO:0051047|GO:0050790|GO:0030030|GO:0031983|GO:0051781|GO:0060324|GO:0051301|GO:0043086|GO:0048869|GO:0030029|GO:2000145|GO:0042634|GO:0009967|GO:0044249|GO:0042704|GO:0019538|GO:0023014|GO:0010033|GO:0051891|GO:0001558|GO:0031324|GO:0042635|GO:0031323|GO:0010256|GO:0048732|GO:0050878|GO:0003013|GO:0005768|GO:0006996|GO:0000165|GO:0016192|GO:1902533|GO:2001235|GO:0032268|GO:0000902|GO:0031175|GO:0048705|GO:0045682|GO:0010468|GO:0005126|GO:0090132|GO:0045216|GO:0030168|GO:0051216|GO:0055123|GO:0007166|GO:0001654|GO:0032956|GO:2000736|GO:0002009|GO:0033993|GO:0030424|GO:0001944|GO:0043412|GO:0072594|GO:0022617|GO:0051795|GO:0033630|GO:0007010|GO:0030097|GO:0072358|GO:0042417|GO:0031410|GO:0010629|GO:0010720|GO:0022405|GO:1903053|GO:0046982|GO:0007596|GO:0035051|GO:0048738|GO:1901216|GO:0010717|GO:0003007|GO:0070997|GO:0051223|GO:0045823|GO:0015031|GO:0005125|GO:0048820|GO:0022612|GO:0007050|GO:0000904|GO:0009790|GO:0010628|GO:0030334|GO:0001667|GO:0007009|GO:0016023|GO:0006887|GO:0045726|GO:0051347|GO:0002718|GO:0051798|GO:0036211|GO:0032269|GO:0033628|GO:0071560|GO:0070201|GO:0060537|GO:0042060|GO:0046907|GO:0048872|GO:0050714|GO:0007431|GO:0051046|GO:0043029|GO:0060485|GO:0031098|GO:0060326|GO:0007599|GO:0009306|GO:0051099|GO:0051247|GO:0051346|GO:0070848|GO:0031988|GO:0022604|GO:0050678|GO:0018958|GO:0016301|GO:0035272|GO:0050680|GO:0043588|GO:1901214|GO:0001974|GO:0030036|GO:0034613|GO:0060038|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0060205|GO:0042476|GO:0033043|GO:0044267|GO:0051174|GO:0048864|GO:0010467|GO:0017038|GO:0032990|GO:0007399|GO:0046903|GO:0071310|GO:0060395|GO:0097485|GO:0030198|GO:0051246|GO:0010770|GO:0017145|GO:0009059|GO:0030154|GO:0034774|GO:0001501|GO:0048858|GO:0061448|GO:0030335|GO:0061035|GO:0043068|GO:1903827|GO:0048566|GO:1902531|GO:0008083|GO:0072359|GO:0031091|GO:0016773|GO:0008015|GO:0006584|GO:0051797|GO:0010557|GO:0042803|GO:0043067|GO:0048545|GO:0006606|GO:0045165|GO:0097190|GO:2000738|GO:0071621|GO:1904424|GO:0001540|GO:0042633|GO:0048666|GO:0008347|GO:0030182|GO:0008016|GO:0007411|GO:0070304|GO:0010715|GO:0048863|GO:0010923|GO:0016311|GO:0010934|GO:0045113|GO:0060317|GO:0060393|GO:0033365|GO:0045055|GO:0031401|GO:1990266|GO:0042416|GO:0043065|GO:0051169|GO:0042423|GO:0043408|GO:0010769|GO:0043523|GO:0014068|GO:0048103|GO:0032570|GO:0060047|GO:0045112|GO:0010936|GO:0097192|GO:0014031|GO:2001236|GO:0043525|GO:0050708|GO:0071363|GO:0016310|GO:0006605|GO:2001238|GO:0008544|GO:0030593|GO:0007179|GO:0048663|GO:0061564|GO:0006886|GO:0048017|GO:0051493|GO:0090091|GO:0007167|GO:0010862|GO:0030199|GO:0043410|GO:0048730|GO:0010631|GO:0032872|GO:0042981|GO:0004672|GO:0048762|GO:0007435|GO:0051402|GO:0005160|GO:0014066|GO:1900180|GO:0014706|GO:0022008|GO:1904426|GO:0048667|GO:0006464|GO:0007184|GO:0032909|GO:0031093|GO:0048812|GO:0001837|GO:0097191|GO:0051403|GO:0006924|GO:0043549|GO:0010002|GO:0006915|GO:0098773|GO:0010921|GO:0033674|GO:0009712|GO:0006470|GO:0035304|GO:2000108|GO:0034714|GO:0006913|GO:0045859|GO:0048015|GO:0045860|GO:0007409|GO:0005114|GO:0006468|GO:0048699|GO:2001239|GO:0042325|GO:2001241|GO:0010693|GO:0001932|GO:0042063|GO:0004674|GO:0032874|GO:0001934|GO:0007178|GO:0035305|GO:0002576|GO:0042327|GO:0035303|GO:0034504|GO:0035308|GO:0051170|GO:0070230|GO:0060389|GO:0014065|GO:0032147|GO:0070228|GO:0070231|GO:0070234|GO:0070232 locomotion|developmental process|extracellular matrix|growth|signal transducer activity|reproduction|immune system process|signaling|cell|rhythmic process|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of immune system process|amide binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|cartilage condensation|receptor signaling protein activity|single organism reproductive process|organic substance metabolic process|leukocyte migration|immune response|response to abiotic stimulus|ovulation cycle|cellular metabolic process|cellular localization|leukocyte homeostasis|cell motility|regulation of signaling|negative regulation of growth|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|membrane-bounded organelle|regulation of growth|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|extracellular space|positive regulation of immune system process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|ovulation cycle process|positive regulation of cellular protein localization|protein binding|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|heart development|regulation of cellular localization|positive regulation of cell proliferation|negative regulation of cytokine production|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|digestive tract development|heart valve morphogenesis|coagulation|peptide binding|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|negative regulation of cartilage development|tissue development|cell development|positive regulation of epidermis development|neuronal cell body|positive regulation of epithelial to mesenchymal transition|transport|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|animal organ development|regulation of activation-induced cell death of T cells|positive regulation of activation-induced cell death of T cells|regulation of cell division|receptor binding|face morphogenesis|positive regulation of cell growth|extracellular structure organization|secretion by cell|regulation of cell adhesion|hair follicle morphogenesis|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|positive regulation of cell death|regulation of cytokine production|organ growth|regulation of binding|secretory granule|cardiac muscle tissue growth|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|negative regulation of cell growth|hair follicle development|cytoplasm|regulation of actin filament-based process|cytokine production|cell-cell signaling|cell adhesion mediated by integrin|response to wounding|heart valve development|head development|sensory organ development|regulation of protein localization|positive regulation of protein transport|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|homeostatic process|cell activation|neuron projection|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic organ development|cytokine production involved in immune response|epithelial cell proliferation|positive regulation of blood circulation|establishment of protein localization|tissue remodeling|somatodendritic compartment|positive regulation of cell cycle|catagen|response to drug|regulation of cell communication|body morphogenesis|positive regulation of catalytic activity|regulation of immune response|angiogenesis|positive regulation of protein localization to nucleus|protein localization|cell communication|negative regulation of molecular function|positive regulation of ossification|membrane organization|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|regulation of ossification|lymphocyte homeostasis|ossification|establishment of localization in cell|positive regulation of cell adhesion|head morphogenesis|receptor signaling protein serine/threonine kinase activity|negative regulation of immune response|response to hormone|cell death|positive regulation of epithelial cell migration|negative regulation of cell proliferation|response to hypoxia|leukocyte chemotaxis|positive regulation of secretion|regulation of catalytic activity|cell projection organization|vesicle lumen|positive regulation of cell division|face development|cell division|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|regulation of cell motility|regulation of hair cycle|positive regulation of signal transduction|cellular biosynthetic process|uterine wall breakdown|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|positive regulation of cardioblast differentiation|regulation of cell growth|negative regulation of cellular metabolic process|positive regulation of hair cycle|regulation of cellular metabolic process|endomembrane system organization|gland development|regulation of body fluid levels|circulatory system process|endosome|organelle organization|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|skeletal system morphogenesis|regulation of epidermis development|regulation of gene expression|cytokine receptor binding|epithelium migration|cell-cell junction organization|platelet activation|cartilage development|digestive system development|cell surface receptor signaling pathway|eye development|regulation of actin cytoskeleton organization|regulation of stem cell differentiation|morphogenesis of an epithelium|response to lipid|axon|vasculature development|macromolecule modification|establishment of protein localization to organelle|extracellular matrix disassembly|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|cytoskeleton organization|hemopoiesis|cardiovascular system development|dopamine metabolic process|cytoplasmic vesicle|negative regulation of gene expression|positive regulation of cell development|hair cycle process|regulation of extracellular matrix organization|protein heterodimerization activity|blood coagulation|cardiocyte differentiation|cardiac muscle tissue development|positive regulation of neuron death|regulation of epithelial to mesenchymal transition|heart morphogenesis|neuron death|regulation of protein transport|positive regulation of heart contraction|protein transport|cytokine activity|hair follicle maturation|gland morphogenesis|cell cycle arrest|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|regulation of cell migration|ameboidal-type cell migration|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|exocytosis|positive regulation of integrin biosynthetic process|positive regulation of transferase activity|regulation of cytokine production involved in immune response|positive regulation of hair follicle development|protein modification process|negative regulation of cellular protein metabolic process|regulation of cell adhesion mediated by integrin|cellular response to transforming growth factor beta stimulus|regulation of establishment of protein localization|muscle tissue development|wound healing|intracellular transport|homeostasis of number of cells|positive regulation of protein secretion|salivary gland development|regulation of secretion|T cell homeostasis|mesenchyme development|stress-activated protein kinase signaling cascade|cell chemotaxis|hemostasis|protein secretion|positive regulation of binding|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|membrane-bounded vesicle|regulation of cell morphogenesis|regulation of epithelial cell proliferation|phenol-containing compound metabolic process|kinase activity|exocrine system development|negative regulation of epithelial cell proliferation|skin development|regulation of neuron death|blood vessel remodeling|actin cytoskeleton organization|cellular protein localization|cardiac muscle cell proliferation|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic membrane-bounded vesicle lumen|odontogenesis|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|gene expression|protein import|cell part morphogenesis|nervous system development|secretion|cellular response to organic substance|SMAD protein signal transduction|neuron projection guidance|extracellular matrix organization|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|stem cell division|macromolecule biosynthetic process|cell differentiation|secretory granule lumen|skeletal system development|cell projection morphogenesis|connective tissue development|positive regulation of cell migration|regulation of cartilage development|positive regulation of programmed cell death|regulation of cellular protein localization|embryonic digestive tract development|regulation of intracellular signal transduction|growth factor activity|circulatory system development|platelet alpha granule|phosphotransferase activity, alcohol group as acceptor|blood circulation|catecholamine metabolic process|regulation of hair follicle development|positive regulation of macromolecule biosynthetic process|protein homodimerization activity|regulation of programmed cell death|response to steroid hormone|protein import into nucleus|cell fate commitment|apoptotic signaling pathway|positive regulation of stem cell differentiation|granulocyte chemotaxis|regulation of GTP binding|beta-amyloid binding|hair cycle|neuron development|glial cell migration|neuron differentiation|regulation of heart contraction|axon guidance|positive regulation of stress-activated protein kinase signaling cascade|regulation of extracellular matrix disassembly|stem cell differentiation|negative regulation of phosphatase activity|dephosphorylation|macrophage cytokine production|regulation of integrin biosynthetic process|cardiac epithelial to mesenchymal transition|regulation of pathway-restricted SMAD protein phosphorylation|protein localization to organelle|regulated exocytosis|positive regulation of protein modification process|neutrophil migration|dopamine biosynthetic process|positive regulation of apoptotic process|nuclear transport|catecholamine biosynthetic process|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|somatic stem cell division|response to progesterone|heart contraction|integrin biosynthetic process|negative regulation of macrophage cytokine production|extrinsic apoptotic signaling pathway in absence of ligand|mesenchymal cell development|regulation of extrinsic apoptotic signaling pathway|positive regulation of neuron apoptotic process|regulation of protein secretion|cellular response to growth factor stimulus|phosphorylation|protein targeting|positive regulation of extrinsic apoptotic signaling pathway|epidermis development|neutrophil chemotaxis|transforming growth factor beta receptor signaling pathway|neuron fate commitment|axon development|intracellular protein transport|inositol lipid-mediated signaling|regulation of cytoskeleton organization|positive regulation of extracellular matrix disassembly|enzyme linked receptor protein signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|collagen fibril organization|positive regulation of MAPK cascade|epidermis morphogenesis|epithelial cell migration|regulation of stress-activated MAPK cascade|regulation of apoptotic process|protein kinase activity|mesenchymal cell differentiation|salivary gland morphogenesis|neuron apoptotic process|transforming growth factor beta receptor binding|regulation of phosphatidylinositol 3-kinase signaling|regulation of protein localization to nucleus|striated muscle tissue development|neurogenesis|positive regulation of GTP binding|cell morphogenesis involved in neuron differentiation|cellular protein modification process|SMAD protein import into nucleus|regulation of transforming growth factor beta2 production|platelet alpha granule lumen|neuron projection morphogenesis|epithelial to mesenchymal transition|extrinsic apoptotic signaling pathway|stress-activated MAPK cascade|activation-induced cell death of T cells|regulation of kinase activity|cardioblast differentiation|apoptotic process|skin epidermis development|regulation of phosphatase activity|positive regulation of kinase activity|catechol-containing compound metabolic process|protein dephosphorylation|regulation of protein dephosphorylation|positive regulation of leukocyte apoptotic process|type III transforming growth factor beta receptor binding|nucleocytoplasmic transport|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|axonogenesis|type II transforming growth factor beta receptor binding|protein phosphorylation|generation of neurons|regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of phosphorylation|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of alkaline phosphatase activity|regulation of protein phosphorylation|gliogenesis|protein serine/threonine kinase activity|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of dephosphorylation|platelet degranulation|positive regulation of phosphorylation|regulation of dephosphorylation|protein localization to nucleus|negative regulation of protein dephosphorylation|nuclear import|positive regulation of lymphocyte apoptotic process|pathway-restricted SMAD protein phosphorylation|phosphatidylinositol 3-kinase signaling|activation of protein kinase activity|regulation of lymphocyte apoptotic process|T cell apoptotic process|positive regulation of T cell apoptotic process|regulation of T cell apoptotic process K13376 transforming growth factor beta-2[-] hsa05200|hsa04060|hsa05166|hsa04144|hsa05206|hsa04010|hsa05205|hsa05152|hsa04390|hsa05161|hsa04068|hsa04380|hsa04110|hsa05145|hsa05142|hsa04933|hsa05146|hsa05414|hsa05323|hsa04350|hsa05410|hsa05220|hsa05140|hsa05211|hsa05212|hsa05321|hsa05210|hsa05144 Pathways in cancer - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Inflammatory bowel disease (IBD) - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Malaria - Homo sapiens (human) 1:218346235-218444619 25 29 92 371 414 304 0.278100088870494 0.293184806565637 0.922699683439246 3.69767177850057 3.77854576167052 3.16927271549627 0.497994859625126 3.54849675188912 -2.83300522999637 9.26543172930427e-13 3.31269699217545e-11 DOWN ENSG00000204172 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 [Source:HGNC Symbol;Acc:HGNC:23463] GO:0008152|GO:0005488|GO:0043167|GO:0009893|GO:0030234|GO:0019222|GO:0008047|GO:0043169|GO:0043085|GO:0050790|GO:0005096|GO:0046872|GO:0051345|GO:0030695|GO:0043087|GO:0043547 metabolic process|binding|ion binding|positive regulation of metabolic process|enzyme regulator activity|regulation of metabolic process|enzyme activator activity|cation binding|positive regulation of catalytic activity|regulation of catalytic activity|GTPase activator activity|metal ion binding|positive regulation of hydrolase activity|GTPase regulator activity|regulation of GTPase activity|positive regulation of GTPase activity - - - - 10:47501854-47523638 42 43 70 203 241 261 1.24463433838321 1.15809988020857 1.8702681789118 5.38998588638842 5.85973742251357 7.24874971212689 1.42433413250119 6.16615767367629 -2.11408415503663 9.52548762296033e-13 3.40160176430452e-11 DOWN ENSG00000187134 AKR1C1 aldo-keto reductase family 1, member C1 [Source:HGNC Symbol;Acc:HGNC:384] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0051606|GO:0016491|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0042445|GO:0016043|GO:0043227|GO:0008289|GO:0009605|GO:0005622|GO:0005515|GO:0048856|GO:0006081|GO:0044255|GO:0009888|GO:0009314|GO:0006810|GO:1901360|GO:0006082|GO:0009410|GO:0005496|GO:0043168|GO:0044281|GO:0031982|GO:0016614|GO:0022607|GO:0009582|GO:0005737|GO:0016705|GO:0016229|GO:0042592|GO:0043177|GO:0030638|GO:0051186|GO:0016651|GO:0004497|GO:0007154|GO:0006629|GO:0007165|GO:0008207|GO:0070062|GO:0042180|GO:0016627|GO:0007586|GO:0009725|GO:0006805|GO:0050892|GO:0010817|GO:0048869|GO:0010876|GO:0010033|GO:0055114|GO:0005829|GO:0009583|GO:0032052|GO:0044597|GO:0048878|GO:0006720|GO:0046683|GO:0016709|GO:0006811|GO:0044241|GO:0007602|GO:0016616|GO:0071466|GO:0044598|GO:0006869|GO:0016655|GO:0042574|GO:0042448|GO:0006461|GO:0008202|GO:0060429|GO:0031406|GO:0016628|GO:1901661|GO:0071310|GO:0030154|GO:0008206|GO:0032870|GO:0009416|GO:0016137|GO:0018636|GO:0047115|GO:0071395|GO:0006820|GO:0015711|GO:0051259|GO:0030855|GO:0015721|GO:0030299|GO:0046942|GO:0009584|GO:0015918|GO:0019752|GO:0047086|GO:0055088|GO:0047718|GO:0004033|GO:0007603|GO:0047023|GO:0047006|GO:0015718|GO:0008106|GO:0047042|GO:0030301|GO:0016101|GO:0032787|GO:0051260|GO:0055092|GO:0001523|GO:0042632|GO:0004032 developmental process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|detection of stimulus|oxidoreductase activity|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|hormone metabolic process|cellular component organization|membrane-bounded organelle|lipid binding|response to external stimulus|intracellular|protein binding|anatomical structure development|cellular aldehyde metabolic process|cellular lipid metabolic process|tissue development|response to radiation|transport|organic cyclic compound metabolic process|organic acid metabolic process|response to xenobiotic stimulus|steroid binding|anion binding|small molecule metabolic process|vesicle|oxidoreductase activity, acting on CH-OH group of donors|cellular component assembly|detection of abiotic stimulus|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|steroid dehydrogenase activity|homeostatic process|organic acid binding|polyketide metabolic process|cofactor metabolic process|oxidoreductase activity, acting on NAD(P)H|monooxygenase activity|cell communication|lipid metabolic process|signal transduction|C21-steroid hormone metabolic process|extracellular exosome|cellular ketone metabolic process|oxidoreductase activity, acting on the CH-CH group of donors|digestion|response to hormone|xenobiotic metabolic process|intestinal absorption|regulation of hormone levels|cellular developmental process|lipid localization|response to organic substance|oxidation-reduction process|cytosol|detection of light stimulus|bile acid binding|daunorubicin metabolic process|chemical homeostasis|isoprenoid metabolic process|response to organophosphorus|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|ion transport|lipid digestion|phototransduction|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|cellular response to xenobiotic stimulus|doxorubicin metabolic process|lipid transport|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|retinal metabolic process|progesterone metabolic process|protein complex assembly|steroid metabolic process|epithelium development|carboxylic acid binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|quinone metabolic process|cellular response to organic substance|cell differentiation|bile acid metabolic process|cellular response to hormone stimulus|response to light stimulus|glycoside metabolic process|phenanthrene 9,10-monooxygenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|cellular response to jasmonic acid stimulus|anion transport|organic anion transport|protein oligomerization|epithelial cell differentiation|bile acid and bile salt transport|intestinal cholesterol absorption|carboxylic acid transport|detection of visible light|sterol transport|carboxylic acid metabolic process|ketosteroid monooxygenase activity|lipid homeostasis|indanol dehydrogenase activity|aldo-keto reductase (NADP) activity|phototransduction, visible light|androsterone dehydrogenase activity|17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity|monocarboxylic acid transport|alcohol dehydrogenase (NADP+) activity|androsterone dehydrogenase (B-specific) activity|cholesterol transport|diterpenoid metabolic process|monocarboxylic acid metabolic process|protein homooligomerization|sterol homeostasis|retinoid metabolic process|cholesterol homeostasis|alditol:NADP+ 1-oxidoreductase activity K00212 20alpha/3alpha-hydroxysteroid dehydrogenase / dihydrodiol dehydrogenase[1.3.1.20] hsa00980|hsa00140 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human) 10:4963253-5107522 4753 5559 4758 15942 14450 18611 32.8011995519066 34.8657140124308 29.6046922043533 98.574000535372 81.8196626917111 120.370627563448 32.4238685895636 100.254763596844 -1.62854264931024 9.82596080971181e-13 3.50471008378896e-11 DOWN ENSG00000143751 SDE2 SDE2 telomere maintenance homolog (S. pombe) [Source:HGNC Symbol;Acc:HGNC:26643] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - 1:225982702-225999331 2557 2585 2059 913 1010 812 45.5029188599984 41.8070160621383 33.035363904658 14.5571730376284 14.7468118423673 13.5423383282379 40.1150996089316 14.2821077360779 1.48993647332945 1.0053733485963e-12 3.5799032708277e-11 UP ENSG00000160563 MED27 mediator complex subunit 27 [Source:HGNC Symbol;Acc:HGNC:2377] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0003824|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0016592|GO:0005667|GO:0006139|GO:0019787|GO:0000151|GO:0044249|GO:0019827|GO:0019538|GO:0031323|GO:0003713|GO:0005730|GO:0010468|GO:0034645|GO:0043412|GO:0004842|GO:0051252|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0061630|GO:0032774|GO:2001141|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:0006352|GO:0006357|GO:1903506|GO:0032446|GO:0006367|GO:0016567 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|catalytic activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|mediator complex|transcription factor complex|nucleobase-containing compound metabolic process|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|regulation of cellular metabolic process|transcription coactivator activity|nucleolus|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|ubiquitin-protein transferase activity|regulation of RNA metabolic process|protein modification process|nuclear lumen|transferase complex|nucleoplasm|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|ubiquitin protein ligase activity|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|protein modification by small protein conjugation|transcription initiation from RNA polymerase II promoter|protein ubiquitination K15170 mediator of RNA polymerase II transcription subunit 27[-] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) 9:131860107-132079908 66 83 76 378 415 242 1.99855048691164 2.28419370600198 2.07491372219296 10.2556201834876 10.3107173484791 6.86780623594582 2.11921930503553 9.14471458930417 -2.10940525239369 1.00607585054748e-12 3.5799032708277e-11 DOWN ENSG00000221955 SLC12A8 solute carrier family 12, member 8 [Source:HGNC Symbol;Acc:HGNC:15595] GO:0005215|GO:0016020|GO:0009987|GO:0022857|GO:0031224|GO:0006810|GO:0055085|GO:0016021|GO:0006811|GO:0015293|GO:0006812|GO:0030001|GO:0015672|GO:0006813 transporter activity|membrane|cellular process|transmembrane transporter activity|intrinsic component of membrane|transport|transmembrane transport|integral component of membrane|ion transport|symporter activity|cation transport|metal ion transport|monovalent inorganic cation transport|potassium ion transport - - - - 3:125082636-125212864 110 140 170 484 495 473 0.610180617083018 0.705789075523034 0.850219718163923 2.40552907546387 2.25289506014207 2.45899517735909 0.722063136923325 2.37247310432168 -1.71619483570267 1.00823033738256e-12 3.58329863002606e-11 DOWN ENSG00000116954 RRAGC Ras-related GTP binding C [Source:HGNC Symbol;Acc:HGNC:19902] GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0006914|GO:0023051|GO:0043227|GO:0009605|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0009991|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0045786|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0031668|GO:0009966|GO:0046983|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:1990131|GO:0009725|GO:0008219|GO:0016236|GO:0000166|GO:0044249|GO:0010033|GO:0042594|GO:0005829|GO:0034645|GO:0046872|GO:0007166|GO:0035639|GO:0046982|GO:0001883|GO:1901652|GO:0007050|GO:0005773|GO:0071417|GO:0043200|GO:0016818|GO:0032549|GO:0043434|GO:0009267|GO:0034613|GO:0012501|GO:0035556|GO:0010467|GO:0071310|GO:0017076|GO:0009059|GO:0019003|GO:0031669|GO:1902531|GO:0016070|GO:0031667|GO:0032870|GO:0005634|GO:0032006|GO:0032561|GO:0031929|GO:0006396|GO:1901653|GO:0000323|GO:0000287|GO:0032774|GO:0007167|GO:0071375|GO:0034198|GO:0032868|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0071230|GO:0006351|GO:0006915|GO:0006366|GO:0006352|GO:0005764|GO:0017111|GO:0032869|GO:0008380|GO:0007169|GO:0006367|GO:0003924|GO:0008286 growth|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|autophagy|regulation of signaling|membrane-bounded organelle|response to external stimulus|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|response to extracellular stimulus|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|cellular response to extracellular stimulus|regulation of signal transduction|protein dimerization activity|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|Gtr1-Gtr2 GTPase complex|response to hormone|cell death|macroautophagy|nucleotide binding|cellular biosynthetic process|response to organic substance|response to starvation|cytosol|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|protein heterodimerization activity|purine nucleoside binding|response to peptide|cell cycle arrest|vacuole|cellular response to organonitrogen compound|response to amino acid|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|response to peptide hormone|cellular response to starvation|cellular protein localization|programmed cell death|intracellular signal transduction|gene expression|cellular response to organic substance|purine nucleotide binding|macromolecule biosynthetic process|GDP binding|cellular response to nutrient levels|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|cellular response to hormone stimulus|nucleus|regulation of TOR signaling|guanyl ribonucleotide binding|TOR signaling|RNA processing|cellular response to peptide|lytic vacuole|magnesium ion binding|RNA biosynthetic process|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|cellular response to amino acid starvation|response to insulin|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|cellular response to amino acid stimulus|transcription, DNA-templated|apoptotic process|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|lysosome|nucleoside-triphosphatase activity|cellular response to insulin stimulus|RNA splicing|transmembrane receptor protein tyrosine kinase signaling pathway|transcription initiation from RNA polymerase II promoter|GTPase activity|insulin receptor signaling pathway K16186 Ras-related GTP-binding protein C/D[-] hsa04150 mTOR signaling pathway - Homo sapiens (human) 1:38838198-38859823 1874 1830 1657 656 765 723 22.3542764305411 19.8391138874611 17.820819915999 7.01120214324091 7.48721569256014 8.08272981987763 20.0047367446671 7.52704921855956 1.41018533320838 1.02955999167973e-12 3.65475433907333e-11 UP ENSG00000164144 ARFIP1 ADP ribosylation factor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21496] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0044089|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0060341|GO:0006810|GO:0051130|GO:0032535|GO:0043168|GO:0032940|GO:0005543|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0032970|GO:0032880|GO:0045184|GO:0019904|GO:0008104|GO:0051649|GO:0030029|GO:0031334|GO:0043254|GO:0005794|GO:0006996|GO:0005829|GO:0005802|GO:0032956|GO:0007010|GO:0035091|GO:0051223|GO:0015031|GO:0070201|GO:0046907|GO:0051046|GO:0009306|GO:0006461|GO:0030036|GO:0034613|GO:0032273|GO:0033043|GO:0046903|GO:0000139|GO:0030832|GO:0010638|GO:0034622|GO:0030838|GO:0043623|GO:0050708|GO:0008064|GO:0006886|GO:0051493|GO:1901981|GO:0007015|GO:0051495|GO:0030833|GO:0032588|GO:0051125|GO:0051258|GO:0045010|GO:0070273|GO:0008154|GO:0034314|GO:0030041|GO:0034315 cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|lipid binding|intracellular|protein binding|endomembrane system|organelle membrane|regulation of cellular localization|transport|positive regulation of cellular component organization|regulation of cellular component size|anion binding|secretion by cell|phospholipid binding|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|regulation of actin filament-based process|regulation of protein localization|establishment of protein localization|protein domain specific binding|protein localization|establishment of localization in cell|actin filament-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|Golgi apparatus|organelle organization|cytosol|trans-Golgi network|regulation of actin cytoskeleton organization|cytoskeleton organization|phosphatidylinositol binding|regulation of protein transport|protein transport|regulation of establishment of protein localization|intracellular transport|regulation of secretion|protein secretion|protein complex assembly|actin cytoskeleton organization|cellular protein localization|positive regulation of protein polymerization|regulation of organelle organization|secretion|Golgi membrane|regulation of actin filament length|positive regulation of organelle organization|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|cellular protein complex assembly|regulation of protein secretion|regulation of actin polymerization or depolymerization|intracellular protein transport|regulation of cytoskeleton organization|phosphatidylinositol phosphate binding|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|trans-Golgi network membrane|regulation of actin nucleation|protein polymerization|actin nucleation|phosphatidylinositol-4-phosphate binding|actin polymerization or depolymerization|Arp2/3 complex-mediated actin nucleation|actin filament polymerization|regulation of Arp2/3 complex-mediated actin nucleation - - - - 4:152687727-152918463 168 202 306 847 690 913 1.15477297278038 1.26188271499097 1.89637060773146 5.21637885423629 3.89139120311156 5.88149852676125 1.43767543183427 4.9964228613697 -1.7971575703174 1.03084739064186e-12 3.65497838482448e-11 DOWN ENSG00000185955 C7orf61 chromosome 7 open reading frame 61 [Source:HGNC Symbol;Acc:HGNC:22135] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - 7:100456615-100464271 63 63 82 10 13 16 2.82590131836115 2.56825013039902 3.31621228092773 0.40190775273833 0.478423101143299 0.672614432177738 2.90345457656263 0.517648428686456 2.48772596346843 1.03361845124703e-12 3.66045613802238e-11 UP ENSG00000111647 UHRF1BP1L UHRF1 binding protein 1-like [Source:HGNC Symbol;Acc:HGNC:29102] - - - - - - 12:100028455-100142848 93 120 200 515 551 572 0.790782489295515 0.927332161255961 1.53327042403823 3.92355054980275 3.84409250125401 4.55826920243804 1.08379502486324 4.1086374178316 -1.92256809047817 1.06067264952104e-12 3.75181531739349e-11 DOWN ENSG00000197019 SERTAD1 SERTA domain containing 1 [Source:HGNC Symbol;Acc:HGNC:17932] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0050790|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0043412|GO:0051252|GO:0010628|GO:0036211|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0016310|GO:0006464|GO:0000079|GO:0043549|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0045859|GO:0006357|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0071900 cell|cellular process|metabolic process|binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|regulation of RNA metabolic process|positive regulation of gene expression|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorylation|cellular protein modification process|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|regulation of protein serine/threonine kinase activity - - - - 19:40421592-40426025 929 818 579 236 250 150 31.0854120685757 24.8756262771971 17.4676084460586 7.07538707167296 6.86354294721065 4.7039409215539 24.4762155972771 6.21429031347917 1.97771896559191 1.09049950292479e-12 3.85275410181264e-11 UP ENSG00000174912 METTL15P1 methyltransferase like 15 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:31926] - - - - - - 3:156713884-156714928 5 10 8 56 70 59 0.338469804033755 0.615189493579612 0.488253029639912 3.39636316704177 3.8877342492217 3.74292114309874 0.48063744241776 3.67567285312074 -2.93498742158787 1.09813687245129e-12 3.87515108630742e-11 DOWN ENSG00000250033 SLC7A11-AS1 SLC7A11 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44064] - - - - - - 4:138057464-138178177 7 9 10 57 66 83 0.0702166862041413 0.082049935248085 0.0904396653385047 0.512281965580191 0.543185709415362 0.78026404337133 0.0809020955969103 0.611910572788961 -2.91907184853803 1.1159336679141e-12 3.93330386327125e-11 DOWN ENSG00000166908 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma [Source:HGNC Symbol;Acc:HGNC:23786] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0019222|GO:0042802|GO:1902117|GO:0044255|GO:0010506|GO:1902115|GO:0051130|GO:0009991|GO:0043168|GO:0001882|GO:0016772|GO:0031982|GO:0019637|GO:0031325|GO:0051128|GO:0033554|GO:0022607|GO:0043231|GO:0005737|GO:0010508|GO:0010646|GO:0007154|GO:0006629|GO:0005783|GO:0070062|GO:0016236|GO:0000166|GO:0031323|GO:0006996|GO:0046486|GO:0035639|GO:0001883|GO:2000785|GO:0005773|GO:0016239|GO:0032549|GO:0016241|GO:0016301|GO:0070925|GO:0006796|GO:0033043|GO:0017076|GO:2000786|GO:0030258|GO:0000045|GO:0031667|GO:0016773|GO:0006644|GO:0007033|GO:0010638|GO:0044090|GO:0005524|GO:0030554|GO:0016310|GO:0044088|GO:0005776|GO:0016307|GO:0046834|GO:0006650|GO:0016309|GO:0046854|GO:0046488|GO:0016308 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|endomembrane system|transferase activity|regulation of metabolic process|identical protein binding|positive regulation of organelle assembly|cellular lipid metabolic process|regulation of autophagy|regulation of organelle assembly|positive regulation of cellular component organization|response to extracellular stimulus|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|positive regulation of autophagy|regulation of cell communication|cell communication|lipid metabolic process|endoplasmic reticulum|extracellular exosome|macroautophagy|nucleotide binding|regulation of cellular metabolic process|organelle organization|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|purine nucleoside binding|regulation of autophagosome assembly|vacuole|positive regulation of macroautophagy|ribonucleoside binding|regulation of macroautophagy|kinase activity|organelle assembly|phosphate-containing compound metabolic process|regulation of organelle organization|purine nucleotide binding|positive regulation of autophagosome assembly|lipid modification|autophagosome assembly|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|phospholipid metabolic process|vacuole organization|positive regulation of organelle organization|positive regulation of vacuole organization|ATP binding|adenyl nucleotide binding|phosphorylation|regulation of vacuole organization|autophagosome|phosphatidylinositol phosphate kinase activity|lipid phosphorylation|glycerophospholipid metabolic process|1-phosphatidylinositol-5-phosphate 4-kinase activity|phosphatidylinositol phosphorylation|phosphatidylinositol metabolic process|1-phosphatidylinositol-4-phosphate 5-kinase activity K00920 1-phosphatidylinositol-5-phosphate 4-kinase[2.7.1.149] hsa04810|hsa04070|hsa00562 Regulation of actin cytoskeleton - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 12:57591174-57603418 308 363 533 1175 1243 1244 2.95255878876112 3.16253165460904 4.6066947569417 10.0921492266777 9.77658745688059 11.1762885502359 3.57392840010395 10.3483417445981 -1.53381696671291 1.13732928779794e-12 4.00398921673581e-11 DOWN ENSG00000172409 CLP1 cleavage and polyadenylation factor I subunit 1 [Source:HGNC Symbol;Acc:HGNC:16999] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0009892|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0030902|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0007420|GO:0022607|GO:0043231|GO:0005737|GO:0005849|GO:0060322|GO:0051186|GO:0016458|GO:0006139|GO:0021695|GO:0022037|GO:0000166|GO:0021549|GO:0044249|GO:0022613|GO:0019538|GO:0010468|GO:0034645|GO:0035639|GO:0007417|GO:0031047|GO:0010629|GO:0001883|GO:0006777|GO:0032549|GO:0022618|GO:0031981|GO:0005654|GO:0016301|GO:0006796|GO:0044267|GO:0010467|GO:0007399|GO:0017076|GO:0009059|GO:0016070|GO:0043545|GO:0016773|GO:0005634|GO:0016441|GO:0000214|GO:0043631|GO:0032561|GO:0090501|GO:0034622|GO:0006396|GO:0051731|GO:0032774|GO:0005524|GO:0034660|GO:0030554|GO:0016310|GO:0010608|GO:0019205|GO:0032324|GO:0030423|GO:0009108|GO:0040029|GO:0016071|GO:0005525|GO:0090305|GO:0019001|GO:0006351|GO:0035194|GO:0006378|GO:0016246|GO:0006366|GO:0051733|GO:0006399|GO:0006397|GO:0006379|GO:0008380|GO:0006353|GO:0035087|GO:0031123|GO:0008033|GO:0000375|GO:0046404|GO:0051736|GO:0031124|GO:0006369|GO:0000398|GO:0006388 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|hindbrain development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|brain development|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|mRNA cleavage factor complex|head development|cofactor metabolic process|gene silencing|nucleobase-containing compound metabolic process|cerebellar cortex development|metencephalon development|nucleotide binding|cerebellum development|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|central nervous system development|gene silencing by RNA|negative regulation of gene expression|purine nucleoside binding|Mo-molybdopterin cofactor biosynthetic process|ribonucleoside binding|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|nervous system development|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|molybdopterin cofactor metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|posttranscriptional gene silencing|tRNA-intron endonuclease complex|RNA polyadenylation|guanyl ribonucleotide binding|RNA phosphodiester bond hydrolysis|cellular macromolecular complex assembly|RNA processing|polynucleotide 5'-hydroxyl-kinase activity|RNA biosynthetic process|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|phosphorylation|posttranscriptional regulation of gene expression|nucleobase-containing compound kinase activity|molybdopterin cofactor biosynthetic process|targeting of mRNA for destruction involved in RNA interference|coenzyme biosynthetic process|regulation of gene expression, epigenetic|mRNA metabolic process|GTP binding|nucleic acid phosphodiester bond hydrolysis|guanyl nucleotide binding|transcription, DNA-templated|posttranscriptional gene silencing by RNA|mRNA polyadenylation|RNA interference|transcription from RNA polymerase II promoter|polydeoxyribonucleotide kinase activity|tRNA metabolic process|mRNA processing|mRNA cleavage|RNA splicing|DNA-templated transcription, termination|siRNA loading onto RISC involved in RNA interference|RNA 3'-end processing|tRNA processing|RNA splicing, via transesterification reactions|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity|mRNA 3'-end processing|termination of RNA polymerase II transcription|mRNA splicing, via spliceosome|tRNA splicing, via endonucleolytic cleavage and ligation K14399 polyribonucleotide 5'-hydroxyl-kinase[2.7.1.78] hsa03015 mRNA surveillance pathway - Homo sapiens (human) 11:57648992-57661868 729 831 802 328 342 263 6.6710460431885 6.91110469620703 6.61690332914482 2.6892903434294 2.56779818829953 2.25554166282048 6.73301802284678 2.5042100648498 1.42689773926684 1.14074236323118e-12 4.01127473638443e-11 UP ENSG00000118922 KLF12 Kruppel-like factor 12 [Source:HGNC Symbol;Acc:HGNC:6346] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0000981|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0046872|GO:0010629|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0010467|GO:0001227|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0000977 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 13:73686089-74133905 32 68 55 287 298 741 0.196289155067558 0.379078784371898 0.30417037264036 1.57732358438667 1.49977473876809 4.25978774559262 0.293179437359939 2.44562868958246 -3.06034955538618 1.24431522559959e-12 4.37032785235883e-11 DOWN ENSG00000183044 ABAT 4-aminobutyrate aminotransferase [Source:HGNC Symbol;Acc:HGNC:23] GO:0032502|GO:0032991|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0019953|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0007155|GO:0043227|GO:0044708|GO:0048037|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0007269|GO:0005515|GO:0043234|GO:0016740|GO:0007626|GO:0048856|GO:0019222|GO:0042802|GO:0060341|GO:0007618|GO:0050817|GO:0042133|GO:0016337|GO:0050804|GO:0042391|GO:0006725|GO:0046887|GO:0030534|GO:0006810|GO:1901360|GO:0006082|GO:0051536|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0032940|GO:0030902|GO:0030155|GO:0043270|GO:0031982|GO:0031325|GO:0007420|GO:0050806|GO:0098609|GO:0035640|GO:0043231|GO:0043169|GO:0019899|GO:0010243|GO:0031652|GO:0005737|GO:0006520|GO:0003012|GO:0007267|GO:0009611|GO:0060322|GO:0032880|GO:0051222|GO:0042592|GO:0050819|GO:0001775|GO:0043005|GO:0009966|GO:0046983|GO:0045184|GO:0046883|GO:0048871|GO:0042493|GO:0010646|GO:0007162|GO:0008104|GO:0050865|GO:0007154|GO:0022037|GO:0007165|GO:0070062|GO:0030170|GO:0051649|GO:0032144|GO:0001505|GO:0001666|GO:0008217|GO:0051047|GO:0051048|GO:1903531|GO:0021549|GO:0010817|GO:0010035|GO:0009967|GO:0044249|GO:0010033|GO:0031323|GO:0050878|GO:0003013|GO:0043271|GO:0007568|GO:0006836|GO:0006936|GO:0030193|GO:0030168|GO:0046872|GO:0042135|GO:0007166|GO:0090276|GO:0048148|GO:0002793|GO:0050432|GO:0042417|GO:0007417|GO:0015844|GO:0010544|GO:0007596|GO:0009308|GO:0001659|GO:0060078|GO:0034109|GO:0051223|GO:0015031|GO:0051957|GO:0032145|GO:0090257|GO:0010038|GO:1904450|GO:0014053|GO:0070201|GO:0008483|GO:0042060|GO:0042886|GO:0006811|GO:0050714|GO:0030195|GO:0022408|GO:0022407|GO:0051046|GO:0043279|GO:0009063|GO:0045776|GO:1990234|GO:0007599|GO:0097151|GO:0009914|GO:0009306|GO:0033604|GO:0008652|GO:0005759|GO:0005739|GO:0018958|GO:0007620|GO:0043269|GO:0045987|GO:0061045|GO:0010543|GO:0014070|GO:0060359|GO:0007399|GO:0046903|GO:0010039|GO:0008015|GO:0006584|GO:0042803|GO:0042220|GO:0097305|GO:0015837|GO:0009448|GO:0090277|GO:0050796|GO:0002790|GO:0030073|GO:0006820|GO:0015711|GO:0070459|GO:0006939|GO:0070527|GO:0006937|GO:0006812|GO:0015696|GO:0045964|GO:0046395|GO:0050708|GO:0090330|GO:0015833|GO:0046942|GO:0045471|GO:0003867|GO:1902722|GO:0032024|GO:0009449|GO:0060080|GO:0035094|GO:0044070|GO:0070474|GO:0019752|GO:0006865|GO:0009450|GO:0034111|GO:0090331|GO:0031649|GO:0046717|GO:0046879|GO:0042053|GO:0047298|GO:0033602|GO:0061041|GO:0009712|GO:0015718|GO:0030072|GO:0006940|GO:0006835|GO:0015812|GO:0014051|GO:0070471|GO:0014059|GO:0032787|GO:0015872|GO:0015672|GO:0007268|GO:0015810|GO:0070472 developmental process|macromolecular complex|reproduction|behavior|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|sexual reproduction|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cell adhesion|membrane-bounded organelle|single-organism behavior|cofactor binding|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|neurotransmitter secretion|protein binding|protein complex|transferase activity|locomotory behavior|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cellular localization|mating|coagulation|neurotransmitter metabolic process|single organismal cell-cell adhesion|modulation of synaptic transmission|regulation of membrane potential|cellular aromatic compound metabolic process|positive regulation of hormone secretion|adult behavior|transport|organic cyclic compound metabolic process|organic acid metabolic process|iron-sulfur cluster binding|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|secretion by cell|hindbrain development|regulation of cell adhesion|positive regulation of ion transport|vesicle|positive regulation of cellular metabolic process|brain development|positive regulation of synaptic transmission|cell-cell adhesion|exploration behavior|intracellular membrane-bounded organelle|cation binding|enzyme binding|response to organonitrogen compound|positive regulation of heat generation|cytoplasm|cellular amino acid metabolic process|muscle system process|cell-cell signaling|response to wounding|head development|regulation of protein localization|positive regulation of protein transport|homeostatic process|negative regulation of coagulation|cell activation|neuron projection|regulation of signal transduction|protein dimerization activity|establishment of protein localization|regulation of hormone secretion|multicellular organismal homeostasis|response to drug|regulation of cell communication|negative regulation of cell adhesion|protein localization|regulation of cell activation|cell communication|metencephalon development|signal transduction|extracellular exosome|pyridoxal phosphate binding|establishment of localization in cell|4-aminobutyrate transaminase complex|regulation of neurotransmitter levels|response to hypoxia|regulation of blood pressure|positive regulation of secretion|negative regulation of secretion|negative regulation of secretion by cell|cerebellum development|regulation of hormone levels|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|negative regulation of ion transport|aging|neurotransmitter transport|muscle contraction|regulation of blood coagulation|platelet activation|metal ion binding|neurotransmitter catabolic process|cell surface receptor signaling pathway|regulation of peptide hormone secretion|behavioral response to cocaine|positive regulation of peptide secretion|catecholamine secretion|dopamine metabolic process|central nervous system development|monoamine transport|negative regulation of platelet activation|blood coagulation|amine metabolic process|temperature homeostasis|regulation of postsynaptic membrane potential|homotypic cell-cell adhesion|regulation of protein transport|protein transport|positive regulation of amino acid transport|succinate-semialdehyde dehydrogenase binding|regulation of muscle system process|response to metal ion|positive regulation of aspartate secretion|negative regulation of gamma-aminobutyric acid secretion|regulation of establishment of protein localization|transaminase activity|wound healing|amide transport|ion transport|positive regulation of protein secretion|negative regulation of blood coagulation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of secretion|response to alkaloid|cellular amino acid catabolic process|negative regulation of blood pressure|transferase complex|hemostasis|positive regulation of inhibitory postsynaptic potential|hormone transport|protein secretion|negative regulation of catecholamine secretion|cellular amino acid biosynthetic process|mitochondrial matrix|mitochondrion|phenol-containing compound metabolic process|copulation|regulation of ion transport|positive regulation of smooth muscle contraction|negative regulation of wound healing|regulation of platelet activation|response to organic cyclic compound|response to ammonium ion|nervous system development|secretion|response to iron ion|blood circulation|catecholamine metabolic process|protein homodimerization activity|response to cocaine|response to alcohol|amine transport|gamma-aminobutyric acid metabolic process|positive regulation of peptide hormone secretion|regulation of insulin secretion|peptide secretion|insulin secretion|anion transport|organic anion transport|prolactin secretion|smooth muscle contraction|platelet aggregation|regulation of muscle contraction|cation transport|ammonium transport|positive regulation of dopamine metabolic process|carboxylic acid catabolic process|regulation of protein secretion|regulation of platelet aggregation|peptide transport|carboxylic acid transport|response to ethanol|4-aminobutyrate transaminase activity|positive regulation of prolactin secretion|positive regulation of insulin secretion|gamma-aminobutyric acid biosynthetic process|inhibitory postsynaptic potential|response to nicotine|regulation of anion transport|positive regulation of uterine smooth muscle contraction|carboxylic acid metabolic process|amino acid transport|gamma-aminobutyric acid catabolic process|negative regulation of homotypic cell-cell adhesion|negative regulation of platelet aggregation|heat generation|acid secretion|hormone secretion|regulation of dopamine metabolic process|(S)-3-amino-2-methylpropionate transaminase activity|negative regulation of dopamine secretion|regulation of wound healing|catechol-containing compound metabolic process|monocarboxylic acid transport|peptide hormone secretion|regulation of smooth muscle contraction|dicarboxylic acid transport|gamma-aminobutyric acid transport|gamma-aminobutyric acid secretion|uterine smooth muscle contraction|regulation of dopamine secretion|monocarboxylic acid metabolic process|dopamine transport|monovalent inorganic cation transport|synaptic transmission|aspartate transport|regulation of uterine smooth muscle contraction K13524 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase[2.6.1.22] hsa01100|hsa04727|hsa00280|hsa00250|hsa00640|hsa00410|hsa00650 Metabolic pathways - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Valine, leucine and isoleucine degradation - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human)|beta-Alanine metabolism - Homo sapiens (human)|Butanoate metabolism - Homo sapiens (human) 16:8674565-8784575 52 57 89 561 240 430 0.254117033240157 0.253154172239367 0.392129862302118 2.45633658898179 0.962292789036578 1.96935867818233 0.299800355927214 1.79599601873357 -2.58271015080725 1.25785087205862e-12 4.41267684305969e-11 DOWN ENSG00000135976 ANKRD36 ankyrin repeat domain 36 [Source:HGNC Symbol;Acc:HGNC:24079] GO:0005488|GO:0005515 binding|protein binding - - - - 2:97113496-97264521 57 67 119 346 336 470 0.347824252969087 0.371573469975459 0.654711983844424 1.89173616144067 1.68226508564071 2.68790361877153 0.458036568929657 2.08730162195097 -2.18810439917242 1.28297265021074e-12 4.49552411964688e-11 DOWN ENSG00000140525 FANCI Fanconi anemia complementation group I [Source:HGNC Symbol;Acc:HGNC:25568] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0045786|GO:0043231|GO:0019899|GO:0005737|GO:0006139|GO:0019538|GO:0031323|GO:0032268|GO:0003677|GO:0000075|GO:1903047|GO:0043412|GO:0070182|GO:0044770|GO:0036211|GO:0000278|GO:0036297|GO:0031981|GO:0007346|GO:0010564|GO:0051247|GO:0045930|GO:0005654|GO:0006259|GO:0032270|GO:0044267|GO:0051246|GO:0005634|GO:0006974|GO:0010948|GO:0031401|GO:0007093|GO:0000086|GO:0044772|GO:0044774|GO:0000077|GO:1901990|GO:0007095|GO:1901987|GO:0006464|GO:0044773|GO:1901991|GO:0010389|GO:0044818|GO:0010972|GO:1902750|GO:1902749|GO:0031572|GO:0032446|GO:0031398|GO:0031396|GO:0016567 cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|nucleobase-containing compound metabolic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|DNA binding|cell cycle checkpoint|mitotic cell cycle process|macromolecule modification|DNA polymerase binding|cell cycle phase transition|protein modification process|mitotic cell cycle|interstrand cross-link repair|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|nucleoplasm|DNA metabolic process|positive regulation of cellular protein metabolic process|cellular protein metabolic process|regulation of protein metabolic process|nucleus|cellular response to DNA damage stimulus|negative regulation of cell cycle process|positive regulation of protein modification process|mitotic cell cycle checkpoint|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|mitotic DNA integrity checkpoint|DNA damage checkpoint|regulation of mitotic cell cycle phase transition|mitotic G2 DNA damage checkpoint|regulation of cell cycle phase transition|cellular protein modification process|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|regulation of G2/M transition of mitotic cell cycle|mitotic G2/M transition checkpoint|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of cell cycle G2/M phase transition|regulation of cell cycle G2/M phase transition|G2 DNA damage checkpoint|protein modification by small protein conjugation|positive regulation of protein ubiquitination|regulation of protein ubiquitination|protein ubiquitination K10895 fanconi anemia group I protein[-] hsa03460 Fanconi anemia pathway - Homo sapiens (human) 15:89243949-89317261 979 1139 1298 3611 3869 2790 5.81699888973332 6.15063656799948 6.95353007512932 19.2239002535681 18.8617959776429 15.5363653603289 6.30705517762071 17.8740205305133 -1.50282572666089 1.28825817146152e-12 4.50875257336604e-11 DOWN ENSG00000164961 KIAA0196 KIAA0196 [Source:HGNC Symbol;Acc:HGNC:28984] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0043229|GO:0044702|GO:0051321|GO:0019953|GO:0051641|GO:0003006|GO:0016043|GO:0043227|GO:0032504|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048609|GO:0007049|GO:0001556|GO:0000212|GO:0048468|GO:0009994|GO:0006810|GO:0022402|GO:0033206|GO:0022607|GO:0043231|GO:0005737|GO:0045184|GO:0071203|GO:0008104|GO:0007276|GO:0007126|GO:0005783|GO:0051649|GO:0051301|GO:0048869|GO:0007017|GO:0007281|GO:0005768|GO:0006996|GO:0005829|GO:0007010|GO:0005769|GO:0015031|GO:0040038|GO:0048477|GO:0046907|GO:0007143|GO:0007051|GO:0006461|GO:0070925|GO:0090306|GO:0030154|GO:0048599|GO:0048469|GO:0000226|GO:0007292|GO:0000910|GO:0051225|GO:0016197 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|binding|intracellular organelle|single organism reproductive process|meiotic cell cycle|sexual reproduction|cellular localization|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|multicellular organismal reproductive process|cell cycle|oocyte maturation|meiotic spindle organization|cell development|oocyte differentiation|transport|cell cycle process|meiotic cytokinesis|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|WASH complex|protein localization|gamete generation|meiotic nuclear division|endoplasmic reticulum|establishment of localization in cell|cell division|cellular developmental process|microtubule-based process|germ cell development|endosome|organelle organization|cytosol|cytoskeleton organization|early endosome|protein transport|polar body extrusion after meiotic divisions|oogenesis|intracellular transport|female meiotic division|spindle organization|protein complex assembly|organelle assembly|spindle assembly involved in meiosis|cell differentiation|oocyte development|cell maturation|microtubule cytoskeleton organization|female gamete generation|cytokinesis|spindle assembly|endosomal transport K18464 WASH complex subunit strumpellin[-] hsa04144 Endocytosis - Homo sapiens (human) 8:125024260-125091840 434 499 587 1485 1622 1337 4.45700117020607 4.65728718962159 5.43506804165819 13.6639651959427 13.6669466200516 12.8680579582713 4.84978546716195 13.3996565914219 -1.46620319209183 1.29928617913574e-12 4.5420245423792e-11 DOWN ENSG00000047644 WWC3 WWC family member 3 [Source:HGNC Symbol;Acc:HGNC:29237] GO:0032502|GO:0040007|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0032947|GO:0044237|GO:0023051|GO:0045926|GO:0040008|GO:0023057|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046620|GO:0046483|GO:0046621|GO:0035265|GO:0019899|GO:0005737|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0048638|GO:0048640|GO:0044249|GO:0031324|GO:0031323|GO:0005829|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0019900|GO:0035556|GO:0010467|GO:1902532|GO:0009059|GO:1902531|GO:0016070|GO:0045892|GO:0032774|GO:0035331|GO:2001141|GO:1902679|GO:0035329|GO:0035330|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 developmental process|growth|structural molecule activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|protein complex scaffold|cellular metabolic process|regulation of signaling|negative regulation of growth|regulation of growth|negative regulation of signaling|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|regulation of organ growth|heterocycle metabolic process|negative regulation of organ growth|organ growth|enzyme binding|cytoplasm|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|regulation of developmental growth|negative regulation of developmental growth|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|kinase binding|intracellular signal transduction|gene expression|negative regulation of intracellular signal transduction|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|negative regulation of hippo signaling|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|hippo signaling|regulation of hippo signaling|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - X:10015562-10144478 361 415 725 1647 1673 1885 3.34240520823211 3.49204984129211 6.05208371746425 13.662927984411 12.7091458450315 16.3565910042328 4.29551292232949 14.2428882778918 -1.72933941896668 1.30295642595596e-12 4.54952761877067e-11 DOWN ENSG00000149177 PTPRJ protein tyrosine phosphatase, receptor type, J [Source:HGNC Symbol;Acc:HGNC:9673] GO:0040011|GO:0040007|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0040013|GO:0042995|GO:0002683|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0016049|GO:0044089|GO:0071704|GO:0006955|GO:0009986|GO:0044237|GO:0048870|GO:0023051|GO:0045926|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0023057|GO:0031252|GO:0016787|GO:0031224|GO:0002684|GO:0002682|GO:0005515|GO:0005886|GO:0019222|GO:0002757|GO:0042127|GO:0006935|GO:0008013|GO:0051130|GO:0005102|GO:0016788|GO:0030155|GO:1901890|GO:0031982|GO:0051128|GO:0022607|GO:0005887|GO:0019899|GO:0030308|GO:0001726|GO:0006928|GO:1901888|GO:0031589|GO:0009966|GO:0001772|GO:0010646|GO:0031226|GO:0050776|GO:0007154|GO:0044092|GO:0070097|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0009968|GO:0070062|GO:0045785|GO:0060242|GO:0043114|GO:0051271|GO:0031256|GO:0008285|GO:0050790|GO:0031253|GO:0043086|GO:0016021|GO:2000145|GO:0009967|GO:0019538|GO:0023014|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0003013|GO:0045295|GO:0000165|GO:1902533|GO:0032268|GO:0045216|GO:0007166|GO:0070851|GO:0043412|GO:0030334|GO:0036211|GO:0032269|GO:0007160|GO:0010640|GO:0010642|GO:0034329|GO:0002429|GO:0050860|GO:1901184|GO:0010810|GO:1901185|GO:0002764|GO:0030336|GO:0032587|GO:0019900|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0050918|GO:1903393|GO:1902532|GO:0051246|GO:0051894|GO:0010811|GO:1902531|GO:0008015|GO:0042578|GO:0043116|GO:0051896|GO:0043491|GO:0016311|GO:0051898|GO:0050856|GO:0043408|GO:0034332|GO:0042058|GO:0016310|GO:0051897|GO:0002768|GO:0007167|GO:0001952|GO:0007044|GO:0042059|GO:0001954|GO:0048041|GO:0016791|GO:0043409|GO:0033673|GO:0019901|GO:0051893|GO:0006464|GO:0050851|GO:0043549|GO:0005161|GO:0034333|GO:0006470|GO:0045859|GO:0006469|GO:0006468|GO:0043407|GO:0043405|GO:0042325|GO:0004721|GO:0001932|GO:0051019|GO:0042326|GO:0050852|GO:0001933|GO:0007169|GO:0035335|GO:0048008|GO:0071901|GO:0071900|GO:0004725|GO:0038127|GO:0007173 locomotion|growth|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|cell projection|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|cell growth|positive regulation of cellular component biogenesis|organic substance metabolic process|immune response|cell surface|cellular metabolic process|cell motility|regulation of signaling|negative regulation of growth|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|negative regulation of signaling|cell leading edge|hydrolase activity|intrinsic component of membrane|positive regulation of immune system process|regulation of immune system process|protein binding|plasma membrane|regulation of metabolic process|immune response-activating signal transduction|regulation of cell proliferation|chemotaxis|beta-catenin binding|positive regulation of cellular component organization|receptor binding|hydrolase activity, acting on ester bonds|regulation of cell adhesion|positive regulation of cell junction assembly|vesicle|regulation of cellular component organization|cellular component assembly|integral component of plasma membrane|enzyme binding|negative regulation of cell growth|ruffle|movement of cell or subcellular component|regulation of cell junction assembly|cell-substrate adhesion|regulation of signal transduction|immunological synapse|regulation of cell communication|intrinsic component of plasma membrane|regulation of immune response|cell communication|negative regulation of molecular function|delta-catenin binding|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|negative regulation of signal transduction|extracellular exosome|positive regulation of cell adhesion|contact inhibition|regulation of vascular permeability|negative regulation of cellular component movement|leading edge membrane|negative regulation of cell proliferation|regulation of catalytic activity|cell projection membrane|negative regulation of catalytic activity|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|circulatory system process|gamma-catenin binding|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell-cell junction organization|cell surface receptor signaling pathway|growth factor receptor binding|macromolecule modification|regulation of cell migration|protein modification process|negative regulation of cellular protein metabolic process|cell-matrix adhesion|regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of platelet-derived growth factor receptor signaling pathway|cell junction assembly|immune response-activating cell surface receptor signaling pathway|negative regulation of T cell receptor signaling pathway|regulation of ERBB signaling pathway|regulation of cell-substrate adhesion|negative regulation of ERBB signaling pathway|immune response-regulating signaling pathway|negative regulation of cell migration|ruffle membrane|kinase binding|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|positive chemotaxis|positive regulation of adherens junction organization|negative regulation of intracellular signal transduction|regulation of protein metabolic process|positive regulation of focal adhesion assembly|positive regulation of cell-substrate adhesion|regulation of intracellular signal transduction|blood circulation|phosphoric ester hydrolase activity|negative regulation of vascular permeability|regulation of protein kinase B signaling|protein kinase B signaling|dephosphorylation|negative regulation of protein kinase B signaling|regulation of T cell receptor signaling pathway|regulation of MAPK cascade|adherens junction organization|regulation of epidermal growth factor receptor signaling pathway|phosphorylation|positive regulation of protein kinase B signaling|immune response-regulating cell surface receptor signaling pathway|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|cell-substrate junction assembly|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of cell-matrix adhesion|focal adhesion assembly|phosphatase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|protein kinase binding|regulation of focal adhesion assembly|cellular protein modification process|antigen receptor-mediated signaling pathway|regulation of kinase activity|platelet-derived growth factor receptor binding|adherens junction assembly|protein dephosphorylation|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|negative regulation of MAP kinase activity|regulation of MAP kinase activity|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|mitogen-activated protein kinase binding|negative regulation of phosphorylation|T cell receptor signaling pathway|negative regulation of protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|peptidyl-tyrosine dephosphorylation|platelet-derived growth factor receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|protein tyrosine phosphatase activity|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K05698 receptor-type tyrosine-protein phosphatase eta[3.1.3.48] hsa04520 Adherens junction - Homo sapiens (human) 11:47980558-48170841 146 136 200 522 578 550 0.751861096176062 0.636507941376925 0.928601969829209 2.4085406997061 2.44220102852878 2.65446589593194 0.772323669127399 2.50173587472227 -1.69565199148472 1.31190849606808e-12 4.57009524406258e-11 DOWN ENSG00000186416 NKRF NFKB repressing factor [Source:HGNC Symbol;Acc:HGNC:19374] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0009890|GO:0006139|GO:0005783|GO:0044249|GO:0031324|GO:0031323|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0003723|GO:0010629|GO:0051252|GO:0031981|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0044822|GO:0006351|GO:0006355|GO:1903507|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|endoplasmic reticulum|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription - - - - X:119588337-119605895 2583 2650 2481 1038 1202 898 17.2143685346753 16.0506495107214 14.9075976992737 6.19814215832606 6.57262980004185 5.60882552522456 16.0575385815568 6.12653249453082 1.39010809184449 1.31187355858025e-12 4.57009524406258e-11 UP ENSG00000128596 CCDC136 coiled-coil domain containing 136 [Source:HGNC Symbol;Acc:HGNC:22225] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 7:128790757-128822132 19 35 33 129 154 181 0.119093560167442 0.199387328083766 0.186499099841797 0.724487501491136 0.79201604244224 1.06328761764514 0.168326662697668 0.859930387192839 -2.35295616040122 1.31344482635796e-12 4.57011443427628e-11 DOWN ENSG00000136631 VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:14579] GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0043229|GO:0006950|GO:0051641|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0050817|GO:0006810|GO:0032940|GO:0043231|GO:0005737|GO:0009611|GO:0022406|GO:0045184|GO:0008104|GO:0051649|GO:0010008|GO:0016021|GO:0050878|GO:0005794|GO:0005768|GO:0016192|GO:0048278|GO:0007596|GO:0015031|GO:0006887|GO:0042060|GO:0046907|GO:0007599|GO:0034613|GO:0046903|GO:0000139|GO:0006904|GO:0006886 cell|membrane|cellular process|response to stimulus|binding|intracellular organelle|response to stress|cellular localization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|coagulation|transport|secretion by cell|intracellular membrane-bounded organelle|cytoplasm|response to wounding|membrane docking|establishment of protein localization|protein localization|establishment of localization in cell|endosome membrane|integral component of membrane|regulation of body fluid levels|Golgi apparatus|endosome|vesicle-mediated transport|vesicle docking|blood coagulation|protein transport|exocytosis|wound healing|intracellular transport|hemostasis|cellular protein localization|secretion|Golgi membrane|vesicle docking involved in exocytosis|intracellular protein transport K12479 vacuolar protein sorting-associated protein 45[-] hsa04144 Endocytosis - Homo sapiens (human) 1:150067293-150145327 173 195 200 577 639 615 1.11665933096981 1.14390494845117 1.16390881080153 3.33693782726606 3.38410082435401 3.72031035040387 1.14149103007417 3.48044966734131 -1.60835418871818 1.33100774763151e-12 4.62583297995238e-11 DOWN ENSG00000180573 HIST1H2AC histone cluster 1, H2ac [Source:HGNC Symbol;Acc:HGNC:4733] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0042127|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0046983|GO:0009890|GO:0016458|GO:0006139|GO:0000790|GO:0070062|GO:0008285|GO:0044249|GO:0000786|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0046982|GO:0051252|GO:0006325|GO:0031981|GO:0005694|GO:0000228|GO:0006342|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045814|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0040029|GO:0006351|GO:0006355|GO:1903507|GO:1903506 macromolecular complex|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|protein dimerization activity|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|nuclear chromatin|extracellular exosome|negative regulation of cell proliferation|cellular biosynthetic process|nucleosome|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|chromatin organization|nuclear lumen|chromosome|nuclear chromosome|chromatin silencing|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription K11251 histone H2A[-] hsa05034|hsa05322 Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 6:26124145-26139116 166 153 305 751 812 758 2.80983525651749 2.35367017055647 4.65465547890514 11.3896590795228 11.2770993841511 12.0246161730309 3.27272030199303 11.5637915455683 -1.82105229240083 1.3764872749524e-12 4.77833152400335e-11 DOWN ENSG00000129493 HEATR5A HEAT repeat containing 5A [Source:HGNC Symbol;Acc:HGNC:20276] GO:0005488 binding - - - - 14:31291791-31420582 423 560 656 1591 1589 1721 2.1500123401218 2.58683265169179 3.00620350191739 7.24549156952861 6.62661891984744 8.19803712692278 2.58101616457699 7.35671587209961 -1.5111226964131 1.4594944194247e-12 5.06059772328747e-11 DOWN ENSG00000214960 ISPD isoprenoid synthase domain containing [Source:HGNC Symbol;Acc:HGNC:37276] GO:0040011|GO:0032502|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0009605|GO:0009058|GO:0016740|GO:0048856|GO:0006486|GO:0044255|GO:0006935|GO:0048468|GO:0007275|GO:0016772|GO:0005975|GO:0006928|GO:0006629|GO:0030030|GO:0048869|GO:0044249|GO:0019538|GO:0000902|GO:0031175|GO:0034645|GO:0043412|GO:0006720|GO:0000904|GO:0006493|GO:0009100|GO:0036211|GO:0008299|GO:0070085|GO:0035268|GO:1901137|GO:0044267|GO:0032990|GO:0008610|GO:0007399|GO:0097485|GO:0009059|GO:0030154|GO:0048858|GO:0016779|GO:0048666|GO:0030182|GO:0007411|GO:0097502|GO:0009101|GO:0043413|GO:0061564|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0035269|GO:0007409|GO:0048699|GO:0050518 locomotion|developmental process|cellular process|metabolic process|response to stimulus|catalytic activity|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|response to external stimulus|biosynthetic process|transferase activity|anatomical structure development|protein glycosylation|cellular lipid metabolic process|chemotaxis|cell development|multicellular organism development|transferase activity, transferring phosphorus-containing groups|carbohydrate metabolic process|movement of cell or subcellular component|lipid metabolic process|cell projection organization|cellular developmental process|cellular biosynthetic process|protein metabolic process|cell morphogenesis|neuron projection development|cellular macromolecule biosynthetic process|macromolecule modification|isoprenoid metabolic process|cell morphogenesis involved in differentiation|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|isoprenoid biosynthetic process|glycosylation|protein mannosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|cell part morphogenesis|lipid biosynthetic process|nervous system development|neuron projection guidance|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|nucleotidyltransferase activity|neuron development|neuron differentiation|axon guidance|mannosylation|glycoprotein biosynthetic process|macromolecule glycosylation|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|protein O-linked mannosylation|axonogenesis|generation of neurons|2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity - - - - 7:16087527-16421322 1 5 5 70 71 32 0.0102308361171915 0.0464749074820323 0.0460975691494432 0.641395322546529 0.595733323214123 0.306697400475435 0.0342677709162223 0.514608682078696 -3.90855154313799 1.46543980670632e-12 5.07531786420075e-11 DOWN ENSG00000185630 PBX1 pre-B-cell leukemia homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8632] GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003006|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0045595|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0022402|GO:0035295|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0072028|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0007389|GO:0001763|GO:0009887|GO:0005667|GO:0048729|GO:0046983|GO:0048598|GO:0072006|GO:0048568|GO:0007548|GO:0009890|GO:0045787|GO:0006139|GO:0044092|GO:0006629|GO:0030278|GO:0001503|GO:0008134|GO:0048869|GO:0044249|GO:0019827|GO:0031324|GO:0031323|GO:0048732|GO:0051090|GO:0050768|GO:0000982|GO:0003677|GO:0048538|GO:0010468|GO:0034645|GO:0090068|GO:0002009|GO:1903047|GO:0072164|GO:0030097|GO:0001655|GO:0010629|GO:0046982|GO:0051252|GO:0048536|GO:0044770|GO:0048754|GO:0010721|GO:0061138|GO:0009790|GO:0010628|GO:0000278|GO:0072001|GO:0003002|GO:0035270|GO:0031981|GO:0007346|GO:0010564|GO:0035162|GO:0005654|GO:0043433|GO:0035019|GO:0030325|GO:0061326|GO:0008202|GO:0060993|GO:0060429|GO:0072073|GO:0035108|GO:0010467|GO:0008610|GO:0007399|GO:0060562|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0001228|GO:0001823|GO:0060173|GO:0016070|GO:0045931|GO:0010557|GO:0005634|GO:0051960|GO:0030182|GO:0048706|GO:0000975|GO:0045893|GO:0009792|GO:0001657|GO:0045892|GO:0000086|GO:0032774|GO:0044772|GO:0043565|GO:2001141|GO:0072078|GO:0001077|GO:0072163|GO:0001658|GO:1902679|GO:0003690|GO:1901990|GO:0006694|GO:0061333|GO:1901989|GO:1901992|GO:0072080|GO:0009952|GO:1901987|GO:0045665|GO:0009954|GO:0022008|GO:0050767|GO:0030326|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0010389|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0060675|GO:1902751|GO:0043009|GO:0010971|GO:1902749|GO:0045664|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|cell cycle process|tube development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|nephron morphogenesis|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|morphogenesis of a branching structure|organ morphogenesis|transcription factor complex|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|nephron development|embryonic organ development|sex differentiation|negative regulation of biosynthetic process|positive regulation of cell cycle|nucleobase-containing compound metabolic process|negative regulation of molecular function|lipid metabolic process|regulation of ossification|ossification|transcription factor binding|cellular developmental process|cellular biosynthetic process|stem cell population maintenance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|regulation of sequence-specific DNA binding transcription factor activity|negative regulation of neurogenesis|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|thymus development|regulation of gene expression|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|morphogenesis of an epithelium|mitotic cell cycle process|mesonephric tubule development|hemopoiesis|urogenital system development|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|spleen development|cell cycle phase transition|branching morphogenesis of an epithelial tube|negative regulation of cell development|morphogenesis of a branching epithelium|embryo development|positive regulation of gene expression|mitotic cell cycle|renal system development|regionalization|endocrine system development|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|embryonic hemopoiesis|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|somatic stem cell population maintenance|adrenal gland development|renal tubule development|steroid metabolic process|kidney morphogenesis|epithelium development|kidney epithelium development|limb morphogenesis|gene expression|lipid biosynthetic process|nervous system development|epithelial tube morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|mesonephros development|limb development|RNA metabolic process|positive regulation of mitotic cell cycle|positive regulation of macromolecule biosynthetic process|nucleus|regulation of nervous system development|neuron differentiation|embryonic skeletal system development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|ureteric bud development|negative regulation of transcription, DNA-templated|G2/M transition of mitotic cell cycle|RNA biosynthetic process|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of RNA biosynthetic process|nephron tubule morphogenesis|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|mesonephric epithelium development|branching involved in ureteric bud morphogenesis|negative regulation of RNA biosynthetic process|double-stranded DNA binding|regulation of mitotic cell cycle phase transition|steroid biosynthetic process|renal tubule morphogenesis|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|nephron tubule development|anterior/posterior pattern specification|regulation of cell cycle phase transition|negative regulation of neuron differentiation|proximal/distal pattern formation|neurogenesis|regulation of neurogenesis|embryonic limb morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of G2/M transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|ureteric bud morphogenesis|positive regulation of cell cycle G2/M phase transition|chordate embryonic development|positive regulation of G2/M transition of mitotic cell cycle|regulation of cell cycle G2/M phase transition|regulation of neuron differentiation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09355 pre-B-cell leukemia transcription factor 1[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 1:164555584-164899296 115 76 152 394 576 659 0.22500205161968 0.135139540797955 0.268130688446244 0.690690446156339 0.924655777895988 1.20838099547623 0.209424093621293 0.941242406509519 -2.16813889125689 1.48902450476735e-12 5.15102405160189e-11 DOWN ENSG00000170962 PDGFD platelet derived growth factor D [Source:HGNC Symbol;Acc:HGNC:30620] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0048520|GO:0071704|GO:0050900|GO:0044237|GO:0050795|GO:0048870|GO:0023051|GO:0040017|GO:0043227|GO:0009605|GO:0009893|GO:0005615|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0008284|GO:0051272|GO:0042127|GO:0036119|GO:0006935|GO:0001822|GO:0009888|GO:0002685|GO:0045123|GO:0001568|GO:0032835|GO:0007275|GO:0048513|GO:0051302|GO:0005102|GO:0031982|GO:0031325|GO:2000147|GO:0033554|GO:0043231|GO:0072111|GO:0010243|GO:0048144|GO:0005737|GO:0050920|GO:0071559|GO:0006928|GO:0002687|GO:0009966|GO:0072006|GO:0006979|GO:0010646|GO:0043085|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0070062|GO:0050790|GO:0051781|GO:0051301|GO:2000145|GO:0010035|GO:0009967|GO:0090184|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0005794|GO:0050921|GO:0000165|GO:1902533|GO:1901724|GO:0032268|GO:0048660|GO:0007166|GO:0002691|GO:0070851|GO:0036120|GO:0001944|GO:0043412|GO:0072358|GO:0035696|GO:0042542|GO:0001655|GO:0072110|GO:0072126|GO:0048659|GO:0071417|GO:0030334|GO:0043200|GO:0048661|GO:0051347|GO:0036211|GO:0071560|GO:0072001|GO:0048145|GO:0060326|GO:0072012|GO:0034599|GO:0051247|GO:0048146|GO:0070848|GO:0071673|GO:0090193|GO:0032270|GO:0000302|GO:0006796|GO:1901342|GO:0035556|GO:0002693|GO:0044267|GO:0051174|GO:0005788|GO:0071310|GO:0000139|GO:0051246|GO:0061448|GO:0030335|GO:1902531|GO:0008083|GO:0072359|GO:0031401|GO:0043408|GO:0014068|GO:0014909|GO:0071363|GO:0016310|GO:0014910|GO:0070371|GO:0071670|GO:0048017|GO:0007167|GO:0014911|GO:0043410|GO:2000439|GO:0014066|GO:0034614|GO:0006464|GO:0043549|GO:0071230|GO:0005161|GO:0070301|GO:0033674|GO:0045859|GO:0048015|GO:0045860|GO:0043406|GO:0006468|GO:0043405|GO:0042325|GO:0070374|GO:0001932|GO:0018193|GO:0001934|GO:0070372|GO:0042327|GO:0007169|GO:0050730|GO:0048008|GO:0046777|GO:0031952|GO:0071902|GO:0014065|GO:0071900|GO:0031954|GO:0018108 locomotion|developmental process|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|positive regulation of behavior|organic substance metabolic process|leukocyte migration|cellular metabolic process|regulation of behavior|cell motility|regulation of signaling|positive regulation of locomotion|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|extracellular space|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|response to platelet-derived growth factor|chemotaxis|kidney development|tissue development|regulation of leukocyte migration|cellular extravasation|blood vessel development|glomerulus development|multicellular organism development|animal organ development|regulation of cell division|receptor binding|vesicle|positive regulation of cellular metabolic process|positive regulation of cell motility|cellular response to stress|intracellular membrane-bounded organelle|cell proliferation involved in kidney development|response to organonitrogen compound|fibroblast proliferation|cytoplasm|regulation of chemotaxis|response to transforming growth factor beta|movement of cell or subcellular component|positive regulation of leukocyte migration|regulation of signal transduction|nephron development|response to oxidative stress|regulation of cell communication|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|extracellular exosome|regulation of catalytic activity|positive regulation of cell division|cell division|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|positive regulation of kidney development|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|positive regulation of chemotaxis|MAPK cascade|positive regulation of intracellular signal transduction|positive regulation of cell proliferation involved in kidney development|regulation of cellular protein metabolic process|regulation of smooth muscle cell proliferation|cell surface receptor signaling pathway|regulation of cellular extravasation|growth factor receptor binding|cellular response to platelet-derived growth factor stimulus|vasculature development|macromolecule modification|cardiovascular system development|monocyte extravasation|response to hydrogen peroxide|urogenital system development|glomerular mesangial cell proliferation|positive regulation of glomerular mesangial cell proliferation|smooth muscle cell proliferation|cellular response to organonitrogen compound|regulation of cell migration|response to amino acid|positive regulation of smooth muscle cell proliferation|positive regulation of transferase activity|protein modification process|cellular response to transforming growth factor beta stimulus|renal system development|regulation of fibroblast proliferation|cell chemotaxis|glomerulus vasculature development|cellular response to oxidative stress|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|response to growth factor|positive regulation of smooth muscle cell chemotaxis|positive regulation of glomerulus development|positive regulation of cellular protein metabolic process|response to reactive oxygen species|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|positive regulation of cellular extravasation|cellular protein metabolic process|regulation of phosphorus metabolic process|endoplasmic reticulum lumen|cellular response to organic substance|Golgi membrane|regulation of protein metabolic process|connective tissue development|positive regulation of cell migration|regulation of intracellular signal transduction|growth factor activity|circulatory system development|positive regulation of protein modification process|regulation of MAPK cascade|positive regulation of phosphatidylinositol 3-kinase signaling|smooth muscle cell migration|cellular response to growth factor stimulus|phosphorylation|regulation of smooth muscle cell migration|ERK1 and ERK2 cascade|smooth muscle cell chemotaxis|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|positive regulation of smooth muscle cell migration|positive regulation of MAPK cascade|positive regulation of monocyte extravasation|regulation of phosphatidylinositol 3-kinase signaling|cellular response to reactive oxygen species|cellular protein modification process|regulation of kinase activity|cellular response to amino acid stimulus|platelet-derived growth factor receptor binding|cellular response to hydrogen peroxide|positive regulation of kinase activity|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of peptidyl-tyrosine phosphorylation|platelet-derived growth factor receptor signaling pathway|protein autophosphorylation|regulation of protein autophosphorylation|positive regulation of protein serine/threonine kinase activity|phosphatidylinositol 3-kinase signaling|regulation of protein serine/threonine kinase activity|positive regulation of protein autophosphorylation|peptidyl-tyrosine phosphorylation K05450 platelet derived growth factor C/D[-] hsa04151|hsa04014|hsa04810|hsa04015|hsa04510|hsa04072|hsa05231|hsa05215|hsa04540|hsa05218 PI3K-Akt signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Melanoma - Homo sapiens (human) 11:103907186-104164379 14 4 19 79 130 118 0.133306789907553 0.0346142426055025 0.163110730079511 0.673970529063108 1.01560974430281 1.05299571800732 0.110343920864189 0.914191997124413 -3.05049003962776 1.49945635126407e-12 5.18110762854601e-11 DOWN ENSG00000198961 PJA2 praja ring finger 2, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:17481] GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0060076|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0044708|GO:0071944|GO:0016874|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0097060|GO:0031090|GO:0050877|GO:0045211|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0051018|GO:0009966|GO:0014069|GO:0010646|GO:0007154|GO:0007165|GO:0005783|GO:0007611|GO:0019787|GO:0019538|GO:0005794|GO:0046872|GO:0043412|GO:0034236|GO:0004842|GO:0034237|GO:0036211|GO:0007613|GO:0019900|GO:0035556|GO:0044267|GO:0050890|GO:0000139|GO:1902531|GO:0005856|GO:0010737|GO:0061630|GO:0035329|GO:0045111|GO:0046914|GO:0007616|GO:0019901|GO:0006464|GO:0010738|GO:0008270|GO:0032446|GO:0016567 synapse|behavior|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|excitatory synapse|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|single-organism behavior|cell periphery|ligase activity|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|transferase activity|synaptic membrane|organelle membrane|neurological system process|postsynaptic membrane|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|protein kinase A binding|regulation of signal transduction|postsynaptic density|regulation of cell communication|cell communication|signal transduction|endoplasmic reticulum|learning or memory|ubiquitin-like protein transferase activity|protein metabolic process|Golgi apparatus|metal ion binding|macromolecule modification|protein kinase A catalytic subunit binding|ubiquitin-protein transferase activity|protein kinase A regulatory subunit binding|protein modification process|memory|kinase binding|intracellular signal transduction|cellular protein metabolic process|cognition|Golgi membrane|regulation of intracellular signal transduction|cytoskeleton|protein kinase A signaling|ubiquitin protein ligase activity|hippo signaling|intermediate filament cytoskeleton|transition metal ion binding|long-term memory|protein kinase binding|cellular protein modification process|regulation of protein kinase A signaling|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 5:109334709-109409994 212 235 574 1455 1505 2205 1.81354991116808 1.82701008746393 4.42709727526439 11.1520172704874 10.5632406287329 17.6778815954738 2.6892190912988 13.1310464982314 -2.28772269672547 1.51803919141527e-12 5.23925341277589e-11 DOWN ENSG00000129103 SUMF2 sulfatase modifying factor 2 [Source:HGNC Symbol;Acc:HGNC:20415] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0042802|GO:0043231|GO:0043169|GO:0005737|GO:0046983|GO:0005783|GO:0019538|GO:0046872|GO:0043412|GO:0036211|GO:0044267|GO:0005788|GO:0042803|GO:0006464|GO:0043687 cell|cellular process|metabolic process|binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|endomembrane system|identical protein binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein dimerization activity|endoplasmic reticulum|protein metabolic process|metal ion binding|macromolecule modification|protein modification process|cellular protein metabolic process|endoplasmic reticulum lumen|protein homodimerization activity|cellular protein modification process|post-translational protein modification - - - - 7:56064002-56080670 1112 1321 1943 4996 4248 4532 6.33889647437738 6.84371160612655 9.98610022841954 25.5169712306025 19.8683304429917 24.2118401574086 7.72290276964116 23.1990472770009 -1.58685044567274 1.5393766938251e-12 5.30676117984462e-11 DOWN ENSG00000165733 BMS1 BMS1, ribosome biogenesis factor [Source:HGNC Symbol;Acc:HGNC:23505] GO:0005623|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0005622|GO:0003676|GO:0043168|GO:0001882|GO:0022607|GO:0043231|GO:0000166|GO:0022613|GO:0006996|GO:0005730|GO:0003723|GO:0035639|GO:0001883|GO:0042254|GO:0032549|GO:0022618|GO:0031981|GO:0070925|GO:0017076|GO:0005634|GO:0034622|GO:0042255|GO:0005524|GO:0030554|GO:0044822 cell|cellular process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|intracellular|nucleic acid binding|anion binding|nucleoside binding|cellular component assembly|intracellular membrane-bounded organelle|nucleotide binding|ribonucleoprotein complex biogenesis|organelle organization|nucleolus|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribosome biogenesis|ribonucleoside binding|ribonucleoprotein complex assembly|nuclear lumen|organelle assembly|purine nucleotide binding|nucleus|cellular macromolecular complex assembly|ribosome assembly|ATP binding|adenyl nucleotide binding|poly(A) RNA binding K14569 ribosome biogenesis protein BMS1[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 10:42782801-42834937 491 615 690 2111 2323 1452 4.47978883023308 5.09953839846325 5.67596042250984 17.2568630877182 17.3897381770695 12.4157049726255 5.08509588373539 15.6874354124711 -1.62526263661 1.56882036696058e-12 5.40202574800937e-11 DOWN ENSG00000164442 CITED2 Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2 [Source:HGNC Symbol;Acc:HGNC:1987] GO:0040011|GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0040013|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0009628|GO:0044237|GO:0003006|GO:0048870|GO:0023051|GO:0000989|GO:0009653|GO:0000785|GO:0007155|GO:0043227|GO:0002262|GO:0009605|GO:0009893|GO:0032504|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0048646|GO:0048609|GO:0019222|GO:0048514|GO:0007507|GO:0045137|GO:0001893|GO:0046697|GO:0051726|GO:0007049|GO:0060136|GO:0001890|GO:0016337|GO:0001824|GO:0035802|GO:0007530|GO:2000020|GO:0035239|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:0009612|GO:1901360|GO:0001568|GO:0010941|GO:0034405|GO:0002088|GO:0007275|GO:0060411|GO:0048513|GO:0034101|GO:0034641|GO:0030155|GO:0031325|GO:0046483|GO:0033554|GO:0001825|GO:0090287|GO:0098609|GO:0061061|GO:0043231|GO:0048608|GO:0046332|GO:0019899|GO:0002089|GO:0005737|GO:0007389|GO:0001076|GO:0007423|GO:0071559|GO:0006928|GO:0009887|GO:0042592|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0007548|GO:0009890|GO:0045787|GO:0003682|GO:0060135|GO:0019904|GO:0060548|GO:0010646|GO:0006139|GO:0001892|GO:0000790|GO:0008406|GO:0007154|GO:0035148|GO:0007565|GO:0051270|GO:0016477|GO:0007165|GO:0003151|GO:0003279|GO:0045785|GO:0008134|GO:0009725|GO:0021675|GO:0008219|GO:0051271|GO:0048645|GO:0021602|GO:0060348|GO:0001666|GO:0048869|GO:2000145|GO:0009967|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:2000146|GO:0048732|GO:0007568|GO:0003205|GO:0003713|GO:0048705|GO:0003143|GO:0048538|GO:0010468|GO:0034645|GO:0003156|GO:0008584|GO:0030218|GO:0003714|GO:0007166|GO:0001654|GO:0002009|GO:0033993|GO:0001944|GO:0046661|GO:0061458|GO:0030097|GO:0072358|GO:0001104|GO:0007417|GO:0001085|GO:0010629|GO:0007498|GO:0043620|GO:0035035|GO:0043069|GO:0009798|GO:0051252|GO:0048536|GO:0035050|GO:0035051|GO:0003007|GO:0061308|GO:0009790|GO:0001889|GO:0010628|GO:0030334|GO:0072175|GO:0060840|GO:0071560|GO:0071456|GO:0060412|GO:0060537|GO:0048844|GO:2000027|GO:0048872|GO:0050693|GO:0035358|GO:0003002|GO:0022407|GO:0035360|GO:0007569|GO:0060485|GO:0035270|GO:0031981|GO:0016331|GO:0003231|GO:0001570|GO:0070848|GO:0061371|GO:0005694|GO:0000228|GO:0030325|GO:0030511|GO:0071453|GO:0030336|GO:0001841|GO:0012501|GO:0003197|GO:0014070|GO:0060429|GO:0048864|GO:0010467|GO:0048562|GO:0007399|GO:0060562|GO:0071310|GO:0060349|GO:0031328|GO:0009059|GO:0030154|GO:0022409|GO:0001501|GO:0060606|GO:0003281|GO:0007517|GO:0001191|GO:0016070|GO:0072359|GO:0033613|GO:0010557|GO:0005634|GO:0001829|GO:0043067|GO:0048545|GO:0030522|GO:0046546|GO:0007422|GO:0031076|GO:0021545|GO:0002521|GO:0060971|GO:0060538|GO:0045893|GO:0048863|GO:0001102|GO:0009792|GO:0061156|GO:0001843|GO:0045892|GO:0043010|GO:0032774|GO:0035357|GO:2001141|GO:0048368|GO:0001838|GO:0014031|GO:0071363|GO:0061418|GO:0043627|GO:1902679|GO:0007179|GO:0048048|GO:0001947|GO:0007167|GO:0001105|GO:0009855|GO:0035914|GO:0042981|GO:0070986|GO:0043066|GO:0002244|GO:0048762|GO:0060972|GO:0048821|GO:0030099|GO:0014706|GO:0001106|GO:0048596|GO:0017015|GO:0006351|GO:0006915|GO:0006355|GO:0048592|GO:0043618|GO:0036294|GO:0014033|GO:0014032|GO:0045944|GO:0006366|GO:0002573|GO:0003140|GO:0097201|GO:1903507|GO:0006357|GO:0048593|GO:0007519|GO:0007368|GO:1903506|GO:0001190|GO:0061428|GO:0043009|GO:0007178|GO:0000122|GO:0032924|GO:1900164|GO:0030851|GO:0001701|GO:0038092 locomotion|developmental process|macromolecular complex|reproduction|immune system process|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|developmental process involved in reproduction|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cell adhesion|membrane-bounded organelle|myeloid cell homeostasis|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|blood vessel morphogenesis|heart development|development of primary sexual characteristics|maternal placenta development|decidualization|regulation of cell cycle|cell cycle|embryonic process involved in female pregnancy|placenta development|single organismal cell-cell adhesion|blastocyst development|adrenal cortex formation|sex determination|positive regulation of male gonad development|tube morphogenesis|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|tube development|response to mechanical stimulus|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to fluid shear stress|lens development in camera-type eye|multicellular organism development|cardiac septum morphogenesis|animal organ development|erythrocyte homeostasis|cellular nitrogen compound metabolic process|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|blastocyst formation|regulation of cellular response to growth factor stimulus|cell-cell adhesion|muscle structure development|intracellular membrane-bounded organelle|reproductive structure development|SMAD binding|enzyme binding|lens morphogenesis in camera-type eye|cytoplasm|pattern specification process|transcription factor activity, RNA polymerase II transcription factor binding|sensory organ development|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|homeostatic process|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|sex differentiation|negative regulation of biosynthetic process|positive regulation of cell cycle|chromatin binding|maternal process involved in female pregnancy|protein domain specific binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|nuclear chromatin|gonad development|cell communication|tube formation|female pregnancy|regulation of cellular component movement|cell migration|signal transduction|outflow tract morphogenesis|cardiac septum development|positive regulation of cell adhesion|transcription factor binding|response to hormone|nerve development|cell death|negative regulation of cellular component movement|organ formation|cranial nerve morphogenesis|bone development|response to hypoxia|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|gland development|aging|cardiac chamber development|transcription coactivator activity|skeletal system morphogenesis|embryonic heart tube morphogenesis|thymus development|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of organ formation|male gonad development|erythrocyte differentiation|transcription corepressor activity|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|response to lipid|vasculature development|male sex differentiation|reproductive system development|hemopoiesis|cardiovascular system development|RNA polymerase II transcription cofactor activity|central nervous system development|RNA polymerase II transcription factor binding|negative regulation of gene expression|mesoderm development|regulation of DNA-templated transcription in response to stress|histone acetyltransferase binding|negative regulation of programmed cell death|axis specification|regulation of RNA metabolic process|spleen development|embryonic heart tube development|cardiocyte differentiation|heart morphogenesis|cardiac neural crest cell development involved in heart development|embryo development|liver development|positive regulation of gene expression|regulation of cell migration|epithelial tube formation|artery development|cellular response to transforming growth factor beta stimulus|cellular response to hypoxia|ventricular septum morphogenesis|muscle tissue development|artery morphogenesis|regulation of organ morphogenesis|homeostasis of number of cells|LBD domain binding|regulation of peroxisome proliferator activated receptor signaling pathway|regionalization|regulation of cell-cell adhesion|positive regulation of peroxisome proliferator activated receptor signaling pathway|cell aging|mesenchyme development|endocrine system development|nuclear lumen|morphogenesis of embryonic epithelium|cardiac ventricle development|vasculogenesis|response to growth factor|determination of heart left/right asymmetry|chromosome|nuclear chromosome|adrenal gland development|positive regulation of transforming growth factor beta receptor signaling pathway|cellular response to oxygen levels|negative regulation of cell migration|neural tube formation|programmed cell death|endocardial cushion development|response to organic cyclic compound|epithelium development|stem cell development|gene expression|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|bone morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|skeletal system development|tube closure|ventricular septum development|muscle organ development|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|circulatory system development|activating transcription factor binding|positive regulation of macromolecule biosynthetic process|nucleus|trophectodermal cell differentiation|regulation of programmed cell death|response to steroid hormone|intracellular receptor signaling pathway|development of primary male sexual characteristics|peripheral nervous system development|embryonic camera-type eye development|cranial nerve development|leukocyte differentiation|embryonic heart tube left/right pattern formation|skeletal muscle organ development|positive regulation of transcription, DNA-templated|stem cell differentiation|RNA polymerase II activating transcription factor binding|embryo development ending in birth or egg hatching|pulmonary artery morphogenesis|neural tube closure|negative regulation of transcription, DNA-templated|camera-type eye development|RNA biosynthetic process|peroxisome proliferator activated receptor signaling pathway|regulation of RNA biosynthetic process|lateral mesoderm development|embryonic epithelial tube formation|mesenchymal cell development|cellular response to growth factor stimulus|regulation of transcription from RNA polymerase II promoter in response to hypoxia|response to estrogen|negative regulation of RNA biosynthetic process|transforming growth factor beta receptor signaling pathway|embryonic eye morphogenesis|heart looping|enzyme linked receptor protein signaling pathway|RNA polymerase II transcription coactivator activity|determination of bilateral symmetry|skeletal muscle cell differentiation|regulation of apoptotic process|left/right axis specification|negative regulation of apoptotic process|hematopoietic progenitor cell differentiation|mesenchymal cell differentiation|left/right pattern formation|erythrocyte development|myeloid cell differentiation|striated muscle tissue development|RNA polymerase II transcription corepressor activity|embryonic camera-type eye morphogenesis|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|eye morphogenesis|regulation of transcription from RNA polymerase II promoter in response to stress|cellular response to decreased oxygen levels|neural crest cell differentiation|neural crest cell development|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|myeloid leukocyte differentiation|determination of left/right asymmetry in lateral mesoderm|negative regulation of transcription from RNA polymerase II promoter in response to stress|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|camera-type eye morphogenesis|skeletal muscle tissue development|determination of left/right symmetry|regulation of nucleic acid-templated transcription|transcriptional activator activity, RNA polymerase II transcription factor binding|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|chordate embryonic development|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|activin receptor signaling pathway|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|granulocyte differentiation|in utero embryonic development|nodal signaling pathway - - - - 6:139371807-139374620 1516 1471 2385 687 718 680 20.8876219323306 18.4197065604987 29.627324208242 8.48095112604683 8.11674713428043 8.78066774384115 22.9782175670238 8.4594553347228 1.44163020870202 1.61815556105296e-12 5.56548572807315e-11 UP ENSG00000100417 PMM1 phosphomannomutase 1 [Source:HGNC Symbol;Acc:HGNC:9114] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0044297|GO:0016853|GO:0009058|GO:0005622|GO:0005515|GO:0006486|GO:0044255|GO:0006725|GO:0043025|GO:1901360|GO:0016866|GO:0034641|GO:0044281|GO:0046483|GO:0043169|GO:0005737|GO:0005975|GO:0036477|GO:0006139|GO:0006629|GO:0044249|GO:0019538|GO:0016868|GO:0005829|GO:0006490|GO:0034645|GO:0046872|GO:0009225|GO:0043412|GO:0006487|GO:0009100|GO:0036211|GO:0005996|GO:0070085|GO:1901137|GO:0044267|GO:0009059|GO:0019318|GO:0009101|GO:0043413|GO:0006488|GO:0018279|GO:0004615|GO:0019673|GO:0006464|GO:0018193|GO:0009298|GO:0043687|GO:0006013 cell|cellular process|metabolic process|binding|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cell body|isomerase activity|biosynthetic process|intracellular|protein binding|protein glycosylation|cellular lipid metabolic process|cellular aromatic compound metabolic process|neuronal cell body|organic cyclic compound metabolic process|intramolecular transferase activity|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|cation binding|cytoplasm|carbohydrate metabolic process|somatodendritic compartment|nucleobase-containing compound metabolic process|lipid metabolic process|cellular biosynthetic process|protein metabolic process|intramolecular transferase activity, phosphotransferases|cytosol|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|metal ion binding|nucleotide-sugar metabolic process|macromolecule modification|protein N-linked glycosylation|glycoprotein metabolic process|protein modification process|monosaccharide metabolic process|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|hexose metabolic process|glycoprotein biosynthetic process|macromolecule glycosylation|dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|phosphomannomutase activity|GDP-mannose metabolic process|cellular protein modification process|peptidyl-amino acid modification|GDP-mannose biosynthetic process|post-translational protein modification|mannose metabolic process K17497 phosphomannomutase[5.4.2.8] hsa01100|hsa00520|hsa00051 Metabolic pathways - Homo sapiens (human)|Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)|Fructose and mannose metabolism - Homo sapiens (human) 22:41576894-41589890 51 62 172 527 549 674 0.428657006027645 0.473599421209875 1.30341705679893 3.96870095711634 3.78599538784605 5.30920077526309 0.735224494678817 4.35463237340849 -2.56629419157511 1.68030911221272e-12 5.7726062411966e-11 DOWN ENSG00000139722 VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:25754] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0030496|GO:0050794|GO:0043229|GO:0051050|GO:0044089|GO:0071704|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0016032|GO:0006810|GO:0051130|GO:0000813|GO:1903772|GO:0060627|GO:0031982|GO:0048524|GO:0051128|GO:1903774|GO:0022607|GO:0043231|GO:0005737|GO:0045184|GO:0048306|GO:0008104|GO:0061024|GO:0070062|GO:0051649|GO:0010008|GO:0019538|GO:0050792|GO:0005768|GO:0006996|GO:0016192|GO:0006900|GO:0016050|GO:0019068|GO:0051604|GO:0015031|GO:0019076|GO:0046907|GO:0005770|GO:0006508|GO:0033043|GO:1903902|GO:0010467|GO:0019058|GO:0046755|GO:0031902|GO:0010638|GO:0019082|GO:1902186|GO:0039702|GO:0016485|GO:0075733|GO:0016197|GO:1902188 macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|midbody|regulation of cellular process|intracellular organelle|positive regulation of transport|positive regulation of cellular component biogenesis|organic substance metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|viral process|transport|positive regulation of cellular component organization|ESCRT I complex|regulation of viral budding via host ESCRT complex|regulation of vesicle-mediated transport|vesicle|positive regulation of viral process|regulation of cellular component organization|positive regulation of viral budding via host ESCRT complex|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|calcium-dependent protein binding|protein localization|membrane organization|extracellular exosome|establishment of localization in cell|endosome membrane|protein metabolic process|regulation of viral process|endosome|organelle organization|vesicle-mediated transport|membrane budding|vesicle organization|virion assembly|protein maturation|protein transport|viral release from host cell|intracellular transport|late endosome|proteolysis|regulation of organelle organization|positive regulation of viral life cycle|gene expression|viral life cycle|viral budding|late endosome membrane|positive regulation of organelle organization|viral protein processing|regulation of viral release from host cell|viral budding via host ESCRT complex|protein processing|intracellular transport of virus|endosomal transport|positive regulation of viral release from host cell K12185 ESCRT-I complex subunit VPS37[-] hsa04144 Endocytosis - Homo sapiens (human) 12:122865328-122896444 771 895 921 330 422 307 7.6663098228237 8.08788679150138 8.25668878985297 2.93997414393069 3.442803479771 2.86087467444109 8.00362846805935 3.08121743271426 1.37715370542379 1.70729581666495e-12 5.85857578284086e-11 UP ENSG00000148400 NOTCH1 notch 1 [Source:HGNC Symbol;Acc:HGNC:7881] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0040013|GO:0002683|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0048521|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0042175|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0009986|GO:0019953|GO:0051051|GO:0044237|GO:0051641|GO:0050795|GO:0045177|GO:0003006|GO:0048870|GO:0023051|GO:0000989|GO:0040017|GO:0009653|GO:0016043|GO:0051707|GO:0045927|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0048609|GO:0019222|GO:0016032|GO:0048514|GO:0007507|GO:0060341|GO:0008284|GO:0051272|GO:0042127|GO:1903706|GO:0048565|GO:0003179|GO:0004857|GO:0001756|GO:0006935|GO:0006959|GO:0045595|GO:0003188|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0045684|GO:0010718|GO:0006810|GO:0035295|GO:0051130|GO:1901360|GO:0048839|GO:0001568|GO:0010941|GO:0016324|GO:0060742|GO:0032835|GO:0007275|GO:0010632|GO:0030324|GO:0060627|GO:0060411|GO:0003676|GO:0045596|GO:0048513|GO:0030279|GO:0005102|GO:0034641|GO:0046620|GO:0043062|GO:0032940|GO:0006952|GO:0030155|GO:0030900|GO:0005912|GO:0003157|GO:0031069|GO:0031982|GO:0048524|GO:0031325|GO:0046483|GO:0051128|GO:1902742|GO:2000147|GO:0042246|GO:0033554|GO:0090287|GO:0007420|GO:0022607|GO:0010942|GO:0007440|GO:0035265|GO:0030141|GO:0061061|GO:0055017|GO:0045597|GO:0043231|GO:0060740|GO:0002437|GO:0048608|GO:0043169|GO:0019899|GO:0010243|GO:1901201|GO:0001942|GO:0005737|GO:0007389|GO:0001763|GO:0001816|GO:0009611|GO:0003170|GO:0060322|GO:0050920|GO:0001076|GO:0007423|GO:0003161|GO:0043235|GO:0060512|GO:0006928|GO:0009887|GO:0021915|GO:0031589|GO:0009966|GO:0048729|GO:0046983|GO:0048598|GO:0072006|GO:0048568|GO:0050673|GO:0045184|GO:0009890|GO:0048639|GO:0003682|GO:0060561|GO:0030323|GO:0003207|GO:0014009|GO:0060548|GO:0010646|GO:0090288|GO:0006139|GO:0009617|GO:0007162|GO:0001525|GO:0008104|GO:0007154|GO:0044092|GO:0035148|GO:0046622|GO:0051270|GO:0007276|GO:0061383|GO:0016477|GO:0007165|GO:0005783|GO:0030278|GO:0060768|GO:0001669|GO:0009968|GO:0048638|GO:1901863|GO:0003279|GO:0001503|GO:0050922|GO:0061351|GO:0009725|GO:0008219|GO:0051271|GO:0048645|GO:0008285|GO:0001666|GO:0050790|GO:0051048|GO:1903531|GO:0030030|GO:0051301|GO:0043086|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0002193|GO:0044249|GO:0010633|GO:0030850|GO:0019827|GO:0019538|GO:0050792|GO:0010033|GO:0031324|GO:0031323|GO:2000146|GO:0048732|GO:0072044|GO:0003272|GO:0005794|GO:0072089|GO:0003162|GO:0003205|GO:0060560|GO:0005112|GO:0050768|GO:0016525|GO:0016192|GO:0050679|GO:1902533|GO:0030111|GO:0000902|GO:0060043|GO:0005829|GO:0031175|GO:0003677|GO:0060039|GO:0045682|GO:0003143|GO:0002040|GO:0010468|GO:0090132|GO:0071773|GO:0034645|GO:0003156|GO:0030178|GO:0034698|GO:2001027|GO:0072143|GO:1901533|GO:0048232|GO:0055123|GO:0060113|GO:0046872|GO:0045668|GO:0090101|GO:0042733|GO:0007166|GO:2000736|GO:0002009|GO:0033993|GO:0003208|GO:0001944|GO:0003241|GO:0048845|GO:0030514|GO:0061458|GO:0030097|GO:0072358|GO:0061005|GO:0007417|GO:0003180|GO:0031410|GO:0001655|GO:0010629|GO:0061314|GO:0002085|GO:0043583|GO:0002237|GO:0010623|GO:0010720|GO:0043620|GO:0060976|GO:0042692|GO:0045605|GO:0043069|GO:0002064|GO:0022405|GO:1903053|GO:0046982|GO:0009798|GO:1901522|GO:0051252|GO:1902263|GO:0060541|GO:0035050|GO:0060421|GO:0021510|GO:0035051|GO:0031100|GO:0048738|GO:0007405|GO:0010717|GO:0003007|GO:0060973|GO:0048754|GO:0010721|GO:0032633|GO:0045667|GO:0060420|GO:0015031|GO:0097150|GO:1901652|GO:0060045|GO:0007492|GO:0061138|GO:0055006|GO:0022612|GO:0000904|GO:0009790|GO:0001889|GO:0060251|GO:0010628|GO:0045844|GO:0030334|GO:0051147|GO:0003181|GO:0010812|GO:0001667|GO:0016023|GO:0006887|GO:0060528|GO:0060840|GO:0071456|GO:0030856|GO:0060412|GO:0060537|GO:0042060|GO:0048844|GO:2000027|GO:0072001|GO:0019083|GO:0006954|GO:0001649|GO:0003273|GO:0060914|GO:0017157|GO:0003002|GO:0051046|GO:0060485|GO:0031981|GO:0060326|GO:0050769|GO:0003231|GO:0045765|GO:0060977|GO:0072012|GO:0045747|GO:0001708|GO:0001570|GO:0009306|GO:0010810|GO:0070848|GO:0031988|GO:0061371|GO:0008593|GO:0005654|GO:0022604|GO:0003209|GO:0030858|GO:0050678|GO:0085029|GO:0003171|GO:0003198|GO:0072141|GO:0043588|GO:0055001|GO:0061326|GO:0014807|GO:0071453|GO:0003176|GO:0030336|GO:0060038|GO:0050663|GO:0012501|GO:0003197|GO:0014070|GO:0060429|GO:1901342|GO:0035556|GO:0072073|GO:0035108|GO:0044267|GO:1903902|GO:0048864|GO:0010467|GO:0032990|GO:0019079|GO:0048562|GO:2000179|GO:0060841|GO:0007399|GO:0060562|GO:0046903|GO:0019058|GO:0071310|GO:0045606|GO:0003190|GO:0000139|GO:2000737|GO:0010594|GO:0030198|GO:0060956|GO:0003344|GO:0060415|GO:0031328|GO:0030510|GO:0045920|GO:0010770|GO:0017145|GO:0009059|GO:0003211|GO:0030154|GO:0048858|GO:0061448|GO:0003281|GO:0060173|GO:0030335|GO:0060837|GO:0043068|GO:0007517|GO:0001191|GO:0048546|GO:1902531|GO:2000177|GO:0016070|GO:0072359|GO:0060253|GO:0032870|GO:0003184|GO:0010557|GO:0030857|GO:0010596|GO:0032496|GO:0005634|GO:0051148|GO:0043067|GO:0061384|GO:0048545|GO:0051960|GO:2000648|GO:0045165|GO:0045995|GO:2000738|GO:0048644|GO:0072091|GO:0003160|GO:0042633|GO:0016202|GO:1901532|GO:0048505|GO:0031490|GO:0048666|GO:0003174|GO:0030182|GO:0060948|GO:0071371|GO:0060271|GO:0003158|GO:0016055|GO:0007283|GO:0060538|GO:0000975|GO:0055024|GO:0051153|GO:0045893|GO:0048863|GO:2000981|GO:0032354|GO:0060317|GO:0003192|GO:0045055|GO:0009792|GO:0090090|GO:0003219|GO:0045445|GO:0010001|GO:0051154|GO:0043065|GO:0043566|GO:0032495|GO:0003270|GO:0060947|GO:0030855|GO:0010769|GO:0060828|GO:0051145|GO:0045892|GO:1902692|GO:0002011|GO:0048103|GO:0046782|GO:0007220|GO:0032774|GO:0043565|GO:0030216|GO:2001141|GO:0014031|GO:0003256|GO:0045608|GO:0071363|GO:0060843|GO:0043537|GO:0043535|GO:0061418|GO:0060979|GO:0045069|GO:0003169|GO:0021515|GO:1902679|GO:0008544|GO:0005509|GO:0045661|GO:0045604|GO:0002042|GO:0035767|GO:0048663|GO:0061564|GO:0003214|GO:0001947|GO:0061053|GO:0030509|GO:0007167|GO:0045070|GO:2000973|GO:0009855|GO:0003222|GO:1903305|GO:2000974|GO:0045618|GO:0014015|GO:0048730|GO:0072080|GO:0035914|GO:0051146|GO:0010631|GO:0048709|GO:0042981|GO:0009952|GO:0097084|GO:0070986|GO:0003215|GO:0072144|GO:0042491|GO:0003229|GO:0043066|GO:0072148|GO:0002244|GO:1903671|GO:0048762|GO:0060972|GO:0003264|GO:0045603|GO:0045665|GO:0060982|GO:0061419|GO:0003213|GO:0055008|GO:0007219|GO:0014706|GO:0050434|GO:0022008|GO:0048667|GO:0045601|GO:2000826|GO:0055010|GO:0050767|GO:0048812|GO:0035137|GO:0001837|GO:0030326|GO:0031960|GO:0045662|GO:0003183|GO:0048708|GO:0006351|GO:0003203|GO:0072602|GO:0060842|GO:0010002|GO:0035282|GO:0006915|GO:0006355|GO:0030513|GO:0043618|GO:0098773|GO:0002052|GO:0036294|GO:0035886|GO:0060379|GO:0048715|GO:0045686|GO:0035116|GO:0048710|GO:0045616|GO:0045607|GO:0045944|GO:0045446|GO:0006366|GO:0007259|GO:0072017|GO:1903507|GO:0006352|GO:0009912|GO:0007221|GO:0006357|GO:0007409|GO:0048699|GO:0007519|GO:0014013|GO:0007368|GO:2000209|GO:0010832|GO:0002320|GO:1903506|GO:0071372|GO:0046425|GO:0003266|GO:0045685|GO:0044212|GO:0060070|GO:0045955|GO:0036003|GO:0048711|GO:0090051|GO:0017156|GO:0001190|GO:0035924|GO:0007386|GO:0046533|GO:0017158|GO:0045687|GO:0035315|GO:0043276|GO:0014902|GO:0042063|GO:0046427|GO:0043009|GO:0010830|GO:0042490|GO:0090049|GO:0007178|GO:0000122|GO:0043542|GO:0045664|GO:0048713|GO:2000811|GO:0009913|GO:0006367|GO:0002067|GO:0001047|GO:0002328|GO:0060563|GO:0001701|GO:0043534 locomotion|developmental process|growth|macromolecular complex|reproduction|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of immune system process|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|negative regulation of behavior|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cell surface|sexual reproduction|negative regulation of transport|cellular metabolic process|cellular localization|regulation of behavior|apical part of cell|developmental process involved in reproduction|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to other organism|positive regulation of growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|viral process|blood vessel morphogenesis|heart development|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|regulation of hemopoiesis|digestive tract development|heart valve morphogenesis|enzyme inhibitor activity|somitogenesis|chemotaxis|humoral immune response|regulation of cell differentiation|heart valve formation|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|positive regulation of epidermis development|positive regulation of epithelial to mesenchymal transition|transport|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|inner ear development|blood vessel development|regulation of cell death|apical plasma membrane|epithelial cell differentiation involved in prostate gland development|glomerulus development|multicellular organism development|regulation of epithelial cell migration|lung development|regulation of vesicle-mediated transport|cardiac septum morphogenesis|nucleic acid binding|negative regulation of cell differentiation|animal organ development|negative regulation of ossification|receptor binding|cellular nitrogen compound metabolic process|regulation of organ growth|extracellular structure organization|secretion by cell|defense response|regulation of cell adhesion|forebrain development|adherens junction|endocardium development|hair follicle morphogenesis|vesicle|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|apoptotic process involved in development|positive regulation of cell motility|tissue regeneration|cellular response to stress|regulation of cellular response to growth factor stimulus|brain development|cellular component assembly|positive regulation of cell death|foregut morphogenesis|organ growth|secretory granule|muscle structure development|cardiac muscle tissue growth|positive regulation of cell differentiation|intracellular membrane-bounded organelle|prostate gland epithelium morphogenesis|inflammatory response to antigenic stimulus|reproductive structure development|cation binding|enzyme binding|response to organonitrogen compound|regulation of extracellular matrix assembly|hair follicle development|cytoplasm|pattern specification process|morphogenesis of a branching structure|cytokine production|response to wounding|heart valve development|head development|regulation of chemotaxis|transcription factor activity, RNA polymerase II transcription factor binding|sensory organ development|cardiac conduction system development|receptor complex|prostate gland morphogenesis|movement of cell or subcellular component|organ morphogenesis|neural tube development|cell-substrate adhesion|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|nephron development|embryonic organ development|epithelial cell proliferation|establishment of protein localization|negative regulation of biosynthetic process|positive regulation of developmental growth|chromatin binding|apoptotic process involved in morphogenesis|respiratory tube development|cardiac chamber formation|glial cell proliferation|negative regulation of cell death|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|response to bacterium|negative regulation of cell adhesion|angiogenesis|protein localization|cell communication|negative regulation of molecular function|tube formation|positive regulation of organ growth|regulation of cellular component movement|gamete generation|trabecula morphogenesis|cell migration|signal transduction|endoplasmic reticulum|regulation of ossification|regulation of epithelial cell proliferation involved in prostate gland development|acrosomal vesicle|negative regulation of signal transduction|regulation of developmental growth|positive regulation of muscle tissue development|cardiac septum development|ossification|negative regulation of chemotaxis|neural precursor cell proliferation|response to hormone|cell death|negative regulation of cellular component movement|organ formation|negative regulation of cell proliferation|response to hypoxia|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|cell projection organization|cell division|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|MAML1-RBP-Jkappa- ICN1 complex|cellular biosynthetic process|negative regulation of epithelial cell migration|prostate gland development|stem cell population maintenance|protein metabolic process|regulation of viral process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|gland development|collecting duct development|endocardial cushion formation|Golgi apparatus|stem cell proliferation|atrioventricular node development|cardiac chamber development|developmental growth involved in morphogenesis|Notch binding|negative regulation of neurogenesis|negative regulation of angiogenesis|vesicle-mediated transport|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of Wnt signaling pathway|cell morphogenesis|regulation of cardiac muscle cell proliferation|cytosol|neuron projection development|DNA binding|pericardium development|regulation of epidermis development|embryonic heart tube morphogenesis|sprouting angiogenesis|regulation of gene expression|epithelium migration|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|regulation of organ formation|negative regulation of Wnt signaling pathway|response to gonadotropin|negative regulation of endothelial cell chemotaxis|mesangial cell development|negative regulation of hematopoietic progenitor cell differentiation|male gamete generation|digestive system development|inner ear receptor cell differentiation|metal ion binding|negative regulation of osteoblast differentiation|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|embryonic digit morphogenesis|cell surface receptor signaling pathway|regulation of stem cell differentiation|morphogenesis of an epithelium|response to lipid|cardiac ventricle morphogenesis|vasculature development|growth involved in heart morphogenesis|venous blood vessel morphogenesis|negative regulation of BMP signaling pathway|reproductive system development|hemopoiesis|cardiovascular system development|cell differentiation involved in kidney development|central nervous system development|aortic valve morphogenesis|cytoplasmic vesicle|urogenital system development|negative regulation of gene expression|Notch signaling involved in heart development|inhibition of neuroepithelial cell differentiation|ear development|response to molecule of bacterial origin|developmental programmed cell death|positive regulation of cell development|regulation of DNA-templated transcription in response to stress|coronary vasculature development|muscle cell differentiation|negative regulation of epidermal cell differentiation|negative regulation of programmed cell death|epithelial cell development|hair cycle process|regulation of extracellular matrix organization|protein heterodimerization activity|axis specification|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|regulation of RNA metabolic process|apoptotic process involved in embryonic digit morphogenesis|respiratory system development|embryonic heart tube development|positive regulation of heart growth|spinal cord development|cardiocyte differentiation|organ regeneration|cardiac muscle tissue development|neuroblast proliferation|regulation of epithelial to mesenchymal transition|heart morphogenesis|cell migration involved in heart development|branching morphogenesis of an epithelial tube|negative regulation of cell development|interleukin-4 production|regulation of osteoblast differentiation|regulation of heart growth|protein transport|neuronal stem cell population maintenance|response to peptide|positive regulation of cardiac muscle cell proliferation|endoderm development|morphogenesis of a branching epithelium|cardiac cell development|gland morphogenesis|cell morphogenesis involved in differentiation|embryo development|liver development|regulation of glial cell proliferation|positive regulation of gene expression|positive regulation of striated muscle tissue development|regulation of cell migration|regulation of muscle cell differentiation|atrioventricular valve morphogenesis|negative regulation of cell-substrate adhesion|ameboidal-type cell migration|cytoplasmic, membrane-bounded vesicle|exocytosis|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|artery development|cellular response to hypoxia|regulation of epithelial cell differentiation|ventricular septum morphogenesis|muscle tissue development|wound healing|artery morphogenesis|regulation of organ morphogenesis|renal system development|viral transcription|inflammatory response|osteoblast differentiation|cell migration involved in endocardial cushion formation|heart formation|regulation of exocytosis|regionalization|regulation of secretion|mesenchyme development|nuclear lumen|cell chemotaxis|positive regulation of neurogenesis|cardiac ventricle development|regulation of angiogenesis|coronary vasculature morphogenesis|glomerulus vasculature development|positive regulation of Notch signaling pathway|cell fate specification|vasculogenesis|protein secretion|regulation of cell-substrate adhesion|response to growth factor|membrane-bounded vesicle|determination of heart left/right asymmetry|regulation of Notch signaling pathway|nucleoplasm|regulation of cell morphogenesis|cardiac atrium morphogenesis|positive regulation of epithelial cell differentiation|regulation of epithelial cell proliferation|extracellular matrix assembly|atrioventricular valve development|epithelial to mesenchymal transition involved in endocardial cushion formation|renal interstitial fibroblast development|skin development|muscle cell development|renal tubule development|regulation of somitogenesis|cellular response to oxygen levels|aortic valve development|negative regulation of cell migration|cardiac muscle cell proliferation|cytokine secretion|programmed cell death|endocardial cushion development|response to organic cyclic compound|epithelium development|regulation of vasculature development|intracellular signal transduction|kidney epithelium development|limb morphogenesis|cellular protein metabolic process|positive regulation of viral life cycle|stem cell development|gene expression|cell part morphogenesis|viral genome replication|embryonic organ morphogenesis|positive regulation of neural precursor cell proliferation|venous blood vessel development|nervous system development|epithelial tube morphogenesis|secretion|viral life cycle|cellular response to organic substance|positive regulation of epidermal cell differentiation|atrioventricular valve formation|Golgi membrane|negative regulation of stem cell differentiation|regulation of endothelial cell migration|extracellular matrix organization|endocardial cell differentiation|pericardium morphogenesis|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|regulation of BMP signaling pathway|negative regulation of exocytosis|positive regulation of cell morphogenesis involved in differentiation|stem cell division|macromolecule biosynthetic process|cardiac ventricle formation|cell differentiation|cell projection morphogenesis|connective tissue development|ventricular septum development|limb development|positive regulation of cell migration|blood vessel endothelial cell differentiation|positive regulation of programmed cell death|muscle organ development|transcriptional repressor activity, RNA polymerase II transcription factor binding|digestive tract morphogenesis|regulation of intracellular signal transduction|regulation of neural precursor cell proliferation|RNA metabolic process|circulatory system development|negative regulation of glial cell proliferation|cellular response to hormone stimulus|pulmonary valve morphogenesis|positive regulation of macromolecule biosynthetic process|negative regulation of epithelial cell differentiation|negative regulation of endothelial cell migration|response to lipopolysaccharide|nucleus|negative regulation of muscle cell differentiation|regulation of programmed cell death|heart trabecula morphogenesis|response to steroid hormone|regulation of nervous system development|positive regulation of stem cell proliferation|cell fate commitment|regulation of embryonic development|positive regulation of stem cell differentiation|muscle organ morphogenesis|regulation of stem cell proliferation|endocardium morphogenesis|hair cycle|regulation of striated muscle tissue development|regulation of hematopoietic progenitor cell differentiation|regulation of timing of cell differentiation|chromatin DNA binding|neuron development|mitral valve development|neuron differentiation|cardiac vascular smooth muscle cell development|cellular response to gonadotropin stimulus|cilium morphogenesis|endothelium development|Wnt signaling pathway|spermatogenesis|skeletal muscle organ development|regulatory region DNA binding|regulation of cardiac muscle tissue development|regulation of striated muscle cell differentiation|positive regulation of transcription, DNA-templated|stem cell differentiation|negative regulation of inner ear receptor cell differentiation|response to follicle-stimulating hormone|cardiac epithelial to mesenchymal transition|mitral valve formation|regulated exocytosis|embryo development ending in birth or egg hatching|negative regulation of canonical Wnt signaling pathway|cardiac right ventricle formation|myoblast differentiation|glial cell differentiation|negative regulation of striated muscle cell differentiation|positive regulation of apoptotic process|structure-specific DNA binding|response to muramyl dipeptide|Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation|cardiac vascular smooth muscle cell differentiation|epithelial cell differentiation|regulation of cell morphogenesis involved in differentiation|regulation of canonical Wnt signaling pathway|smooth muscle cell differentiation|negative regulation of transcription, DNA-templated|regulation of neuroblast proliferation|morphogenesis of an epithelial sheet|somatic stem cell division|regulation of viral transcription|Notch receptor processing|RNA biosynthetic process|sequence-specific DNA binding|keratinocyte differentiation|regulation of RNA biosynthetic process|mesenchymal cell development|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|negative regulation of auditory receptor cell differentiation|cellular response to growth factor stimulus|venous endothelial cell differentiation|negative regulation of blood vessel endothelial cell migration|regulation of blood vessel endothelial cell migration|regulation of transcription from RNA polymerase II promoter in response to hypoxia|vasculogenesis involved in coronary vascular morphogenesis|regulation of viral genome replication|coronary vein morphogenesis|cell differentiation in spinal cord|negative regulation of RNA biosynthetic process|epidermis development|calcium ion binding|regulation of myoblast differentiation|regulation of epidermal cell differentiation|cell migration involved in sprouting angiogenesis|endothelial cell chemotaxis|neuron fate commitment|axon development|cardiac left ventricle morphogenesis|heart looping|somite development|BMP signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of viral genome replication|regulation of pro-B cell differentiation|determination of bilateral symmetry|ventricular trabecula myocardium morphogenesis|regulation of regulated secretory pathway|negative regulation of pro-B cell differentiation|positive regulation of keratinocyte differentiation|positive regulation of gliogenesis|epidermis morphogenesis|nephron tubule development|skeletal muscle cell differentiation|striated muscle cell differentiation|epithelial cell migration|oligodendrocyte differentiation|regulation of apoptotic process|anterior/posterior pattern specification|vascular smooth muscle cell development|left/right axis specification|cardiac right ventricle morphogenesis|glomerular mesangial cell development|auditory receptor cell differentiation|ventricular cardiac muscle tissue development|negative regulation of apoptotic process|epithelial cell fate commitment|hematopoietic progenitor cell differentiation|negative regulation of sprouting angiogenesis|mesenchymal cell differentiation|left/right pattern formation|regulation of cardioblast proliferation|positive regulation of endothelial cell differentiation|negative regulation of neuron differentiation|coronary artery morphogenesis|positive regulation of transcription from RNA polymerase II promoter in response to hypoxia|cardiac right atrium morphogenesis|cardiac muscle tissue morphogenesis|Notch signaling pathway|striated muscle tissue development|positive regulation of viral transcription|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of endothelial cell differentiation|regulation of heart morphogenesis|ventricular cardiac muscle tissue morphogenesis|regulation of neurogenesis|neuron projection morphogenesis|hindlimb morphogenesis|epithelial to mesenchymal transition|embryonic limb morphogenesis|response to corticosteroid|negative regulation of myoblast differentiation|mitral valve morphogenesis|astrocyte differentiation|transcription, DNA-templated|endocardial cushion morphogenesis|interleukin-4 secretion|arterial endothelial cell differentiation|cardioblast differentiation|segmentation|apoptotic process|regulation of transcription, DNA-templated|positive regulation of BMP signaling pathway|regulation of transcription from RNA polymerase II promoter in response to stress|skin epidermis development|positive regulation of neuroblast proliferation|cellular response to decreased oxygen levels|vascular smooth muscle cell differentiation|cardiac muscle cell myoblast differentiation|negative regulation of oligodendrocyte differentiation|negative regulation of glial cell differentiation|embryonic hindlimb morphogenesis|regulation of astrocyte differentiation|regulation of keratinocyte differentiation|regulation of auditory receptor cell differentiation|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|JAK-STAT cascade|distal tubule development|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|auditory receptor cell fate commitment|positive regulation of transcription of Notch receptor target|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|skeletal muscle tissue development|regulation of gliogenesis|determination of left/right symmetry|regulation of anoikis|negative regulation of myotube differentiation|lymphoid progenitor cell differentiation|regulation of nucleic acid-templated transcription|cellular response to follicle-stimulating hormone stimulus|regulation of JAK-STAT cascade|regulation of secondary heart field cardioblast proliferation|regulation of glial cell differentiation|transcription regulatory region DNA binding|canonical Wnt signaling pathway|negative regulation of calcium ion-dependent exocytosis|positive regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of astrocyte differentiation|negative regulation of cell migration involved in sprouting angiogenesis|calcium ion regulated exocytosis|transcriptional activator activity, RNA polymerase II transcription factor binding|cellular response to vascular endothelial growth factor stimulus|compartment pattern specification|negative regulation of photoreceptor cell differentiation|regulation of calcium ion-dependent exocytosis|positive regulation of glial cell differentiation|hair cell differentiation|anoikis|myotube differentiation|gliogenesis|positive regulation of JAK-STAT cascade|chordate embryonic development|regulation of myotube differentiation|mechanoreceptor differentiation|regulation of cell migration involved in sprouting angiogenesis|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|endothelial cell migration|regulation of neuron differentiation|regulation of oligodendrocyte differentiation|negative regulation of anoikis|epidermal cell differentiation|transcription initiation from RNA polymerase II promoter|glandular epithelial cell differentiation|core promoter binding|pro-B cell differentiation|neuroepithelial cell differentiation|in utero embryonic development|blood vessel endothelial cell migration K02599 Notch[-] hsa05206|hsa04919|hsa04330|hsa05020|hsa04320 MicroRNAs in cancer - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Notch signaling pathway - Homo sapiens (human)|Prion diseases - Homo sapiens (human)|Dorso-ventral axis formation - Homo sapiens (human) 9:136494444-136545862 1767 2044 2223 699 907 904 11.7728175155351 12.3767003859438 13.35357493219 4.17271443856027 4.95814467095929 5.64470746102949 12.5010309445563 4.92518885684968 1.34379612604365 1.75622556745439e-12 6.01955890824149e-11 UP ENSG00000072858 SIDT1 SID1 transmembrane family member 1 [Source:HGNC Symbol;Acc:HGNC:25967] GO:0005215|GO:0016020|GO:0022857|GO:0031224|GO:0006810|GO:0022891|GO:0006403|GO:0016021|GO:0050658|GO:0015932|GO:0033227|GO:0051033 transporter activity|membrane|transmembrane transporter activity|intrinsic component of membrane|transport|substrate-specific transmembrane transporter activity|RNA localization|integral component of membrane|RNA transport|nucleobase-containing compound transmembrane transporter activity|dsRNA transport|RNA transmembrane transporter activity - - - - 3:113532296-113629578 5 13 17 89 73 91 0.0324050339180279 0.0765703482992005 0.0993306009864646 0.516787502196809 0.388164347397233 0.552705315036809 0.0694353277345643 0.485885721543617 -2.8068752593962 1.78414556713748e-12 6.10824332125257e-11 DOWN ENSG00000133710 SPINK5 serine peptidase inhibitor, Kazal type 5 [Source:HGNC Symbol;Acc:HGNC:15464] GO:0032502|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0002683|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0006955|GO:0044237|GO:0009653|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0030234|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005789|GO:0005515|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0048514|GO:1903706|GO:0016337|GO:0004857|GO:0006959|GO:0045595|GO:0009888|GO:0001568|GO:0005938|GO:0007275|GO:0048513|GO:0070489|GO:0043062|GO:0006952|GO:0030155|GO:0002759|GO:0031982|GO:0098542|GO:0098609|GO:0030141|GO:0043231|GO:0001942|GO:0005737|GO:1900425|GO:0001775|GO:1900424|GO:0009617|GO:0042640|GO:0050776|GO:0001525|GO:0046649|GO:0050865|GO:0044092|GO:0005783|GO:0070062|GO:0019730|GO:0050777|GO:0050790|GO:0043086|GO:0048869|GO:0019538|GO:0031324|GO:0031323|GO:0016525|GO:0051249|GO:0032268|GO:0005829|GO:0001944|GO:0030097|GO:0072358|GO:0030098|GO:0031410|GO:0030414|GO:0022405|GO:0034109|GO:0048820|GO:0002787|GO:0016023|GO:0032269|GO:0022407|GO:0045765|GO:0042599|GO:0007159|GO:0048471|GO:0051346|GO:0006508|GO:0031988|GO:0043588|GO:0042110|GO:0060429|GO:1901342|GO:0044267|GO:0007399|GO:0002778|GO:0030198|GO:0051246|GO:0042742|GO:0030154|GO:0072359|GO:0002920|GO:0019731|GO:0042633|GO:0030182|GO:0002521|GO:0004866|GO:0010466|GO:0050863|GO:0030855|GO:0030162|GO:0030217|GO:0045619|GO:0052547|GO:0008544|GO:0070486|GO:0045861|GO:0097209|GO:0022008|GO:0098773|GO:1902572|GO:0048699|GO:0045580|GO:0010951|GO:0035315|GO:0004867|GO:0071593|GO:0052548|GO:0009913|GO:1900004 developmental process|immune system process|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|immune response|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|enzyme regulator activity|regulation of developmental process|intracellular|regulation of immune system process|immune system development|endoplasmic reticulum membrane|protein binding|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|regulation of hemopoiesis|single organismal cell-cell adhesion|enzyme inhibitor activity|humoral immune response|regulation of cell differentiation|tissue development|blood vessel development|cell cortex|multicellular organism development|animal organ development|T cell aggregation|extracellular structure organization|defense response|regulation of cell adhesion|regulation of antimicrobial humoral response|vesicle|defense response to other organism|cell-cell adhesion|secretory granule|intracellular membrane-bounded organelle|hair follicle development|cytoplasm|negative regulation of defense response to bacterium|cell activation|regulation of defense response to bacterium|response to bacterium|anagen|regulation of immune response|angiogenesis|lymphocyte activation|regulation of cell activation|negative regulation of molecular function|endoplasmic reticulum|extracellular exosome|antimicrobial humoral response|negative regulation of immune response|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of angiogenesis|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|vasculature development|hemopoiesis|cardiovascular system development|lymphocyte differentiation|cytoplasmic vesicle|peptidase inhibitor activity|hair cycle process|homotypic cell-cell adhesion|hair follicle maturation|negative regulation of antibacterial peptide production|cytoplasmic, membrane-bounded vesicle|negative regulation of cellular protein metabolic process|regulation of cell-cell adhesion|regulation of angiogenesis|lamellar body|leukocyte cell-cell adhesion|perinuclear region of cytoplasm|negative regulation of hydrolase activity|proteolysis|membrane-bounded vesicle|skin development|T cell activation|epithelium development|regulation of vasculature development|cellular protein metabolic process|nervous system development|antibacterial peptide production|extracellular matrix organization|regulation of protein metabolic process|defense response to bacterium|cell differentiation|circulatory system development|regulation of humoral immune response|antibacterial humoral response|hair cycle|neuron differentiation|leukocyte differentiation|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of T cell activation|epithelial cell differentiation|regulation of proteolysis|T cell differentiation|regulation of lymphocyte differentiation|regulation of peptidase activity|epidermis development|leukocyte aggregation|negative regulation of proteolysis|epidermal lamellar body|neurogenesis|skin epidermis development|negative regulation of serine-type peptidase activity|generation of neurons|regulation of T cell differentiation|negative regulation of endopeptidase activity|hair cell differentiation|serine-type endopeptidase inhibitor activity|lymphocyte aggregation|regulation of endopeptidase activity|epidermal cell differentiation|negative regulation of serine-type endopeptidase activity - - - - 5:148025683-148137289 0 0 4 28 31 31 0 0 0.047640001491476 0.331391177363086 0.335985896840111 0.383779677630414 0.0158800004971587 0.350385583944537 -4.46366055601565 1.79810946318951e-12 6.14899884468036e-11 DOWN ENSG00000166224 SGPL1 sphingosine-1-phosphate lyase 1 [Source:HGNC Symbol;Acc:HGNC:10817] GO:0040011|GO:0032502|GO:0040007|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0016829|GO:0044702|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0042698|GO:0019953|GO:0044237|GO:0042445|GO:0003006|GO:0048870|GO:0009653|GO:0043227|GO:0048037|GO:0040008|GO:0032504|GO:0009058|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0002520|GO:0022602|GO:0005789|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0048609|GO:0048514|GO:0045137|GO:0016830|GO:0044255|GO:0008209|GO:0033327|GO:0009791|GO:0001822|GO:1901360|GO:0001568|GO:0006082|GO:0007275|GO:0048513|GO:0060325|GO:0034641|GO:0043168|GO:0044281|GO:0043231|GO:0048608|GO:0031227|GO:0001553|GO:0005737|GO:0060322|GO:0006928|GO:0009887|GO:0035264|GO:0007548|GO:0008210|GO:0010171|GO:0030176|GO:0008406|GO:0007154|GO:0007276|GO:0006629|GO:0016477|GO:0007165|GO:0005783|GO:0048638|GO:0030170|GO:0060323|GO:0040014|GO:0008219|GO:0060324|GO:0010817|GO:0048869|GO:0016021|GO:0044249|GO:0031301|GO:0060021|GO:0048705|GO:0006665|GO:0008584|GO:0048232|GO:0007166|GO:0001944|GO:0008585|GO:0046661|GO:0061458|GO:0030097|GO:0072358|GO:0001655|GO:0016042|GO:0044242|GO:0006631|GO:0046545|GO:0006643|GO:0001667|GO:0072001|GO:0001570|GO:0016831|GO:0008202|GO:0012501|GO:0043603|GO:0008610|GO:0030154|GO:0001501|GO:0072359|GO:0097190|GO:0046546|GO:0007283|GO:0006672|GO:0007167|GO:0030149|GO:0019752|GO:0030148|GO:0046466|GO:0008117|GO:0010761|GO:0006915|GO:0032787|GO:0007169|GO:0048008 locomotion|developmental process|growth|reproduction|immune system process|signaling|cell|rhythmic process|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|lyase activity|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|ovulation cycle|sexual reproduction|cellular metabolic process|hormone metabolic process|developmental process involved in reproduction|cell motility|anatomical structure morphogenesis|membrane-bounded organelle|cofactor binding|regulation of growth|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|immune system development|ovulation cycle process|endoplasmic reticulum membrane|protein binding|endomembrane system|anatomical structure development|organelle membrane|multicellular organismal reproductive process|blood vessel morphogenesis|development of primary sexual characteristics|carbon-carbon lyase activity|cellular lipid metabolic process|androgen metabolic process|Leydig cell differentiation|post-embryonic development|kidney development|organic cyclic compound metabolic process|blood vessel development|organic acid metabolic process|multicellular organism development|animal organ development|face morphogenesis|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|reproductive structure development|intrinsic component of endoplasmic reticulum membrane|luteinization|cytoplasm|head development|movement of cell or subcellular component|organ morphogenesis|multicellular organism growth|sex differentiation|estrogen metabolic process|body morphogenesis|integral component of endoplasmic reticulum membrane|gonad development|cell communication|gamete generation|lipid metabolic process|cell migration|signal transduction|endoplasmic reticulum|regulation of developmental growth|pyridoxal phosphate binding|head morphogenesis|regulation of multicellular organism growth|cell death|face development|regulation of hormone levels|cellular developmental process|integral component of membrane|cellular biosynthetic process|integral component of organelle membrane|palate development|skeletal system morphogenesis|sphingolipid metabolic process|male gonad development|male gamete generation|cell surface receptor signaling pathway|vasculature development|female gonad development|male sex differentiation|reproductive system development|hemopoiesis|cardiovascular system development|urogenital system development|lipid catabolic process|cellular lipid catabolic process|fatty acid metabolic process|development of primary female sexual characteristics|membrane lipid metabolic process|ameboidal-type cell migration|renal system development|vasculogenesis|carboxy-lyase activity|steroid metabolic process|programmed cell death|cellular amide metabolic process|lipid biosynthetic process|cell differentiation|skeletal system development|circulatory system development|apoptotic signaling pathway|development of primary male sexual characteristics|spermatogenesis|ceramide metabolic process|enzyme linked receptor protein signaling pathway|sphingolipid catabolic process|carboxylic acid metabolic process|sphingolipid biosynthetic process|membrane lipid catabolic process|sphinganine-1-phosphate aldolase activity|fibroblast migration|apoptotic process|monocarboxylic acid metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|platelet-derived growth factor receptor signaling pathway - - hsa01100|hsa04071|hsa00600 Metabolic pathways - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human) 10:70815961-70881173 805 905 1152 2622 2699 3120 6.5998070793642 6.74317334904167 8.51534309202081 19.2604331537636 18.1554239684758 23.9728182362805 7.28610784014223 20.4628917861733 -1.48978978568451 1.80656952642598e-12 6.17086117184453e-11 DOWN ENSG00000198879 SFMBT2 Scm-like with four mbt domains 2 [Source:HGNC Symbol;Acc:HGNC:20256] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:0042393|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0016234|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0016235|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|inclusion body|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|aggresome|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 10:7158624-7411486 23 27 22 111 152 117 0.162016663934589 0.172852776418318 0.139718223020709 0.700562659392202 0.878487809578966 0.772397873301996 0.158195887791205 0.783816114091055 -2.30880313461329 1.8116373354749e-12 6.18109954437345e-11 DOWN ENSG00000177666 PNPLA2 patatin like phospholipase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30802] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0016043|GO:0010888|GO:0043227|GO:0071944|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0044255|GO:0010883|GO:0016788|GO:0044281|GO:0019637|GO:0031325|GO:0043231|GO:0005737|GO:0006629|GO:0005783|GO:0019915|GO:0010891|GO:0016021|GO:0044249|GO:0010876|GO:0031323|GO:0006996|GO:0090207|GO:0005829|GO:0008654|GO:0046486|GO:0016042|GO:0050996|GO:0044242|GO:0005811|GO:0050994|GO:0006638|GO:0034389|GO:0016298|GO:0006796|GO:0030730|GO:0008610|GO:0019216|GO:0052689|GO:0006644|GO:0046474|GO:0046461|GO:0004806|GO:0010898|GO:0006639|GO:0006650|GO:0046464|GO:0036155|GO:0006641|GO:0019433 cell|membrane|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|cellular component organization|negative regulation of lipid storage|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|cellular lipid metabolic process|regulation of lipid storage|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|endoplasmic reticulum|lipid storage|negative regulation of sequestering of triglyceride|integral component of membrane|cellular biosynthetic process|lipid localization|regulation of cellular metabolic process|organelle organization|regulation of triglyceride metabolic process|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|lipid catabolic process|positive regulation of lipid catabolic process|cellular lipid catabolic process|lipid particle|regulation of lipid catabolic process|neutral lipid metabolic process|lipid particle organization|lipase activity|phosphate-containing compound metabolic process|sequestering of triglyceride|lipid biosynthetic process|regulation of lipid metabolic process|carboxylic ester hydrolase activity|phospholipid metabolic process|glycerophospholipid biosynthetic process|neutral lipid catabolic process|triglyceride lipase activity|positive regulation of triglyceride catabolic process|acylglycerol metabolic process|glycerophospholipid metabolic process|acylglycerol catabolic process|acylglycerol acyl-chain remodeling|triglyceride metabolic process|triglyceride catabolic process K16816 patatin-like phospholipase domain-containing protein 2[3.1.1.3] hsa01100|hsa04923 Metabolic pathways - Homo sapiens (human)|Regulation of lipolysis in adipocytes - Homo sapiens (human) 11:818902-825573 329 323 661 1416 1734 2323 2.91451916288079 2.60047952363147 5.27942279549041 11.2391075435582 12.6034016108034 19.2863003258672 3.59814049400089 14.3762698267429 -1.99836596733454 1.82200250970891e-12 6.20936791379564e-11 DOWN ENSG00000063761 ADCK1 aarF domain containing kinase 1 [Source:HGNC Symbol;Acc:HGNC:19038] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0005739|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|mitochondrion|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 14:77800083-77935012 40 67 61 259 253 216 0.373035601822597 0.567868116539951 0.512901918163338 2.16415238238204 1.93588152298055 1.88786867769903 0.484601878841962 1.99596752768721 -2.04221634635849 1.87689042708436e-12 6.3891319053793e-11 DOWN ENSG00000115339 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:4125] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0070062|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0048471|GO:0070085|GO:0005795|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0018242|GO:0005509|GO:0031985|GO:0032580|GO:0046914|GO:0018243|GO:0008376|GO:0006464|GO:0016266|GO:0004653|GO:0030145|GO:0018193|GO:0043687 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|protein glycosylation|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|extracellular exosome|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|perinuclear region of cytoplasm|glycosylation|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|protein O-linked glycosylation via serine|calcium ion binding|Golgi cisterna|Golgi cisterna membrane|transition metal ion binding|protein O-linked glycosylation via threonine|acetylgalactosaminyltransferase activity|cellular protein modification process|O-glycan processing|polypeptide N-acetylgalactosaminyltransferase activity|manganese ion binding|peptidyl-amino acid modification|post-translational protein modification K00710 polypeptide N-acetylgalactosaminyltransferase[2.4.1.41] hsa01100|hsa00512 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human) 2:165747591-165794682 301 400 835 1957 2268 2293 2.62246129217351 3.16725972175681 6.55909657297748 15.2767740865484 16.2126564209945 18.7230353726403 4.11627252896927 16.7374886267277 -2.02367266718729 1.88128338566127e-12 6.39679204960497e-11 DOWN ENSG00000240498 CDKN2B-AS1 CDKN2B antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:34341] - - - - - - 9:21994778-22121097 15 17 16 87 95 86 0.169874571677381 0.174978315722391 0.163376373990941 0.882800813522976 0.88274473986667 0.912788868073611 0.169409753796904 0.892778140487752 -2.3977847629842 1.96321197007459e-12 6.66777362395982e-11 DOWN ENSG00000126778 SIX1 SIX homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10887] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0031128|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0008284|GO:0042127|GO:0090102|GO:0045595|GO:0035239|GO:0006725|GO:0061197|GO:0001822|GO:0009888|GO:0048468|GO:0035295|GO:1901360|GO:0048839|GO:0001568|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0072028|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0050803|GO:0061061|GO:0043231|GO:0005737|GO:0000981|GO:0007389|GO:0001763|GO:0072189|GO:0007423|GO:0032880|GO:0006928|GO:0051963|GO:0009887|GO:0005667|GO:0048729|GO:0048598|GO:0072006|GO:0048568|GO:0050673|GO:0009890|GO:0003682|GO:0060548|GO:0061196|GO:0006139|GO:0008104|GO:0035148|GO:0016477|GO:0003151|GO:0048638|GO:0050808|GO:0021675|GO:0008219|GO:0048645|GO:0021602|GO:0060688|GO:2000729|GO:0001759|GO:0048869|GO:0044249|GO:0090184|GO:0061055|GO:0051124|GO:0031324|GO:0040019|GO:0031323|GO:0048732|GO:0072089|GO:0060560|GO:0000982|GO:0005730|GO:0060677|GO:0003677|GO:0048705|GO:0048538|GO:0010468|GO:0034645|GO:0003156|GO:1901215|GO:0007416|GO:0043584|GO:0002009|GO:0001944|GO:0050807|GO:0072164|GO:0072358|GO:0007417|GO:0007528|GO:0001655|GO:0010629|GO:0043583|GO:0042692|GO:0043069|GO:0048483|GO:0051252|GO:0060541|GO:0003007|GO:0070997|GO:0010463|GO:0048754|GO:0072198|GO:0061138|GO:0090103|GO:0009790|GO:0001656|GO:0010628|GO:0030878|GO:0072513|GO:0042474|GO:0072175|GO:0072095|GO:0048486|GO:0060840|GO:0060537|GO:0048844|GO:0060037|GO:2000027|GO:0072001|GO:0042472|GO:0060914|GO:0003002|GO:0007600|GO:0030910|GO:0060485|GO:0035270|GO:0031981|GO:0016331|GO:0090189|GO:0001708|GO:0061548|GO:0072107|GO:0010092|GO:0050678|GO:1901214|GO:0061326|GO:0034613|GO:0008582|GO:0060993|GO:0012501|GO:0060429|GO:0072073|GO:0010467|GO:0048562|GO:0003401|GO:2001014|GO:0007399|GO:0060562|GO:0048701|GO:0043586|GO:0031328|GO:0071599|GO:0009059|GO:0030154|GO:0001501|GO:0001228|GO:0001823|GO:0007517|GO:0021610|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0043067|GO:0051960|GO:2000648|GO:0045165|GO:0045995|GO:0072091|GO:0016202|GO:0021545|GO:0030182|GO:0060602|GO:0060538|GO:0048706|GO:0000975|GO:0051451|GO:0045893|GO:0033365|GO:0009792|GO:0048641|GO:0001657|GO:0050954|GO:0030855|GO:0051145|GO:0045892|GO:0043523|GO:0032774|GO:0043565|GO:2001141|GO:0001838|GO:0072078|GO:0001077|GO:0061550|GO:0072163|GO:0001658|GO:1902679|GO:0090191|GO:0003690|GO:0048663|GO:0061053|GO:0014856|GO:0042471|GO:0061333|GO:0002053|GO:0048665|GO:0072075|GO:0035909|GO:0072080|GO:0035914|GO:0042981|GO:0035904|GO:0043066|GO:0048745|GO:0048704|GO:0051402|GO:0003264|GO:0043524|GO:0014842|GO:0014706|GO:0022008|GO:2000826|GO:0072193|GO:0050767|GO:0043587|GO:0090190|GO:0006351|GO:0006915|GO:0006355|GO:0010464|GO:0060681|GO:0014841|GO:0045944|GO:0006366|GO:0061551|GO:1903507|GO:0007605|GO:0006357|GO:0048699|GO:0007519|GO:1903506|GO:0003266|GO:0044212|GO:0060675|GO:0043009|GO:0000122|GO:0072172|GO:0072079|GO:0045664|GO:0034504|GO:0060676|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|growth|macromolecular complex|immune system process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|developmental induction|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|regulation of cell proliferation|cochlea development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|fungiform papilla morphogenesis|kidney development|tissue development|cell development|tube development|organic cyclic compound metabolic process|inner ear development|blood vessel development|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|nephron morphogenesis|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|regulation of synapse structure or activity|muscle structure development|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|morphogenesis of a branching structure|ureter development|sensory organ development|regulation of protein localization|movement of cell or subcellular component|regulation of synapse assembly|organ morphogenesis|transcription factor complex|tissue morphogenesis|embryonic morphogenesis|nephron development|embryonic organ development|epithelial cell proliferation|negative regulation of biosynthetic process|chromatin binding|negative regulation of cell death|fungiform papilla development|nucleobase-containing compound metabolic process|protein localization|tube formation|cell migration|outflow tract morphogenesis|regulation of developmental growth|synapse organization|nerve development|cell death|organ formation|cranial nerve morphogenesis|regulation of morphogenesis of a branching structure|positive regulation of mesenchymal cell proliferation involved in ureter development|organ induction|cellular developmental process|cellular biosynthetic process|positive regulation of kidney development|myotome development|synaptic growth at neuromuscular junction|negative regulation of cellular metabolic process|positive regulation of embryonic development|regulation of cellular metabolic process|gland development|stem cell proliferation|developmental growth involved in morphogenesis|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nucleolus|ureteric bud elongation|DNA binding|skeletal system morphogenesis|thymus development|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of organ formation|negative regulation of neuron death|synapse assembly|nose development|morphogenesis of an epithelium|vasculature development|regulation of synapse organization|mesonephric tubule development|cardiovascular system development|central nervous system development|neuromuscular junction development|urogenital system development|negative regulation of gene expression|ear development|muscle cell differentiation|negative regulation of programmed cell death|autonomic nervous system development|regulation of RNA metabolic process|respiratory system development|heart morphogenesis|neuron death|mesenchymal cell proliferation|branching morphogenesis of an epithelial tube|mesenchymal cell proliferation involved in ureter development|morphogenesis of a branching epithelium|cochlea morphogenesis|embryo development|metanephros development|positive regulation of gene expression|thyroid gland development|positive regulation of secondary heart field cardioblast proliferation|middle ear morphogenesis|epithelial tube formation|regulation of branch elongation involved in ureteric bud branching|parasympathetic nervous system development|artery development|muscle tissue development|artery morphogenesis|pharyngeal system development|regulation of organ morphogenesis|renal system development|inner ear morphogenesis|heart formation|regionalization|sensory perception|olfactory placode formation|mesenchyme development|endocrine system development|nuclear lumen|morphogenesis of embryonic epithelium|regulation of branching involved in ureteric bud morphogenesis|cell fate specification|ganglion development|positive regulation of ureteric bud formation|specification of organ identity|regulation of epithelial cell proliferation|regulation of neuron death|renal tubule development|cellular protein localization|regulation of synaptic growth at neuromuscular junction|kidney morphogenesis|programmed cell death|epithelium development|kidney epithelium development|gene expression|embryonic organ morphogenesis|axis elongation|regulation of skeletal muscle cell differentiation|nervous system development|epithelial tube morphogenesis|embryonic cranial skeleton morphogenesis|tongue development|positive regulation of cellular biosynthetic process|otic vesicle development|macromolecule biosynthetic process|cell differentiation|skeletal system development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|mesonephros development|muscle organ development|facial nerve morphogenesis|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|regulation of nervous system development|positive regulation of stem cell proliferation|cell fate commitment|regulation of embryonic development|regulation of stem cell proliferation|regulation of striated muscle tissue development|cranial nerve development|neuron differentiation|branch elongation of an epithelium|skeletal muscle organ development|embryonic skeletal system development|regulatory region DNA binding|myoblast migration|positive regulation of transcription, DNA-templated|protein localization to organelle|embryo development ending in birth or egg hatching|regulation of skeletal muscle tissue development|ureteric bud development|sensory perception of mechanical stimulus|epithelial cell differentiation|smooth muscle cell differentiation|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|embryonic epithelial tube formation|nephron tubule morphogenesis|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cranial ganglion development|mesonephric epithelium development|branching involved in ureteric bud morphogenesis|negative regulation of RNA biosynthetic process|negative regulation of branching involved in ureteric bud morphogenesis|double-stranded DNA binding|neuron fate commitment|somite development|skeletal muscle cell proliferation|ear morphogenesis|renal tubule morphogenesis|positive regulation of mesenchymal cell proliferation|neuron fate specification|metanephric mesenchyme development|aorta morphogenesis|nephron tubule development|skeletal muscle cell differentiation|regulation of apoptotic process|aorta development|negative regulation of apoptotic process|smooth muscle tissue development|embryonic skeletal system morphogenesis|neuron apoptotic process|regulation of cardioblast proliferation|negative regulation of neuron apoptotic process|regulation of skeletal muscle satellite cell proliferation|striated muscle tissue development|neurogenesis|regulation of heart morphogenesis|ureter smooth muscle cell differentiation|regulation of neurogenesis|tongue morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of mesenchymal cell proliferation|branch elongation involved in ureteric bud branching|skeletal muscle satellite cell proliferation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|trigeminal ganglion development|negative regulation of nucleic acid-templated transcription|sensory perception of sound|regulation of transcription from RNA polymerase II promoter|generation of neurons|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|regulation of secondary heart field cardioblast proliferation|transcription regulatory region DNA binding|ureteric bud morphogenesis|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|mesonephric tubule formation|nephron tubule formation|regulation of neuron differentiation|protein localization to nucleus|ureteric bud formation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K15614 homeobox protein SIX1[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 14:60643415-60658259 449 497 619 162 223 188 2.93647010309507 2.95403287333168 3.64992414815854 0.949276768791327 1.19660873722384 1.15229950994081 3.18014237486176 1.09939500531866 1.53238152619226 1.99375207800051e-12 6.76380392461674e-11 UP ENSG00000125247 TMTC4 transmembrane and tetratricopeptide repeat containing 4 [Source:HGNC Symbol;Acc:HGNC:25904] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 13:100603927-100675093 75 101 157 400 477 445 0.543014240986031 0.664590372020869 1.02486392469252 2.59483188392808 2.83359125484707 3.01953880049702 0.74415617923314 2.81598731309072 -1.91996349140566 2.06238584048196e-12 6.98870225672513e-11 DOWN ENSG00000166263 STXBP4 syntaxin binding protein 4 [Source:HGNC Symbol;Acc:HGNC:19694] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0051641|GO:0023051|GO:0043227|GO:0005622|GO:0005515|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006810|GO:0022402|GO:0061178|GO:0032940|GO:0031982|GO:0033554|GO:0043231|GO:0010243|GO:0005737|GO:0007267|GO:0032880|GO:0042592|GO:0050673|GO:0045184|GO:0046883|GO:0019725|GO:0045787|GO:0010646|GO:0000149|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0031647|GO:0051649|GO:0009725|GO:0010817|GO:0010033|GO:0050679|GO:0009743|GO:0090068|GO:0007166|GO:0090276|GO:0050821|GO:0048878|GO:0044770|GO:0051223|GO:0015031|GO:1901652|GO:0071417|GO:0070201|GO:0046907|GO:0042886|GO:0055082|GO:0051046|GO:0031981|GO:0043434|GO:0010564|GO:0009914|GO:0009306|GO:0005654|GO:0050678|GO:0034613|GO:0035773|GO:0046903|GO:0071310|GO:0019905|GO:0008643|GO:0043616|GO:0032870|GO:0005856|GO:0005634|GO:0006974|GO:0050796|GO:0071322|GO:0002790|GO:0010837|GO:0030073|GO:0001678|GO:1901653|GO:0034284|GO:0050708|GO:0015833|GO:0006605|GO:0006886|GO:1901989|GO:0007167|GO:0071375|GO:0045111|GO:0010838|GO:0032868|GO:1901987|GO:0046879|GO:0033500|GO:0071333|GO:0042593|GO:0030072|GO:0008645|GO:1902808|GO:1902806|GO:0032869|GO:0007169|GO:0015758|GO:0009749|GO:0008286 signaling|cell|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|cellular localization|regulation of signaling|membrane-bounded organelle|intracellular|protein binding|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|transport|cell cycle process|regulation of insulin secretion involved in cellular response to glucose stimulus|secretion by cell|vesicle|cellular response to stress|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|cell-cell signaling|regulation of protein localization|homeostatic process|epithelial cell proliferation|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|positive regulation of cell cycle|regulation of cell communication|SNARE binding|protein localization|cell communication|signal transduction|extracellular exosome|regulation of protein stability|establishment of localization in cell|response to hormone|regulation of hormone levels|response to organic substance|positive regulation of epithelial cell proliferation|response to carbohydrate|positive regulation of cell cycle process|cell surface receptor signaling pathway|regulation of peptide hormone secretion|protein stabilization|chemical homeostasis|cell cycle phase transition|regulation of protein transport|protein transport|response to peptide|cellular response to organonitrogen compound|regulation of establishment of protein localization|intracellular transport|amide transport|cellular chemical homeostasis|regulation of secretion|nuclear lumen|response to peptide hormone|regulation of cell cycle process|hormone transport|protein secretion|nucleoplasm|regulation of epithelial cell proliferation|cellular protein localization|insulin secretion involved in cellular response to glucose stimulus|secretion|cellular response to organic substance|syntaxin binding|carbohydrate transport|keratinocyte proliferation|cellular response to hormone stimulus|cytoskeleton|nucleus|cellular response to DNA damage stimulus|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|regulation of keratinocyte proliferation|insulin secretion|cellular glucose homeostasis|cellular response to peptide|response to monosaccharide|regulation of protein secretion|peptide transport|protein targeting|intracellular protein transport|positive regulation of cell cycle phase transition|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|intermediate filament cytoskeleton|positive regulation of keratinocyte proliferation|response to insulin|regulation of cell cycle phase transition|hormone secretion|carbohydrate homeostasis|cellular response to glucose stimulus|glucose homeostasis|peptide hormone secretion|hexose transport|positive regulation of cell cycle G1/S phase transition|regulation of cell cycle G1/S phase transition|cellular response to insulin stimulus|transmembrane receptor protein tyrosine kinase signaling pathway|glucose transport|response to glucose|insulin receptor signaling pathway - - - - 17:54968727-55173632 36 74 102 300 400 359 0.127003181289299 0.23725800976765 0.324430754506187 0.948262660212955 1.157812286755 1.18695049095395 0.229563981854379 1.09767514597397 -2.2574829469531 2.07527419090821e-12 7.02440314006506e-11 DOWN ENSG00000163877 SNIP1 Smad nuclear interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:30587] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:1903829|GO:0005515|GO:0019222|GO:0060341|GO:0006725|GO:0006810|GO:0051130|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0051128|GO:0043231|GO:0005737|GO:0032880|GO:0051222|GO:0045184|GO:0009890|GO:0032388|GO:0016458|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0090316|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0072594|GO:0031047|GO:0010629|GO:0007005|GO:0051252|GO:0032386|GO:0051223|GO:1903955|GO:0015031|GO:0032269|GO:0043331|GO:0070201|GO:0046907|GO:0031981|GO:0005654|GO:0034613|GO:0014070|GO:0043603|GO:0035556|GO:0033043|GO:0044267|GO:0010467|GO:0071310|GO:0006626|GO:0051246|GO:0009059|GO:1903827|GO:0016070|GO:0005634|GO:0016441|GO:0010638|GO:0043043|GO:0033365|GO:0033157|GO:0006396|GO:0032774|GO:0017148|GO:0006839|GO:0071359|GO:2001141|GO:0006605|GO:0072655|GO:0010608|GO:0010822|GO:0071407|GO:0016482|GO:0006412|GO:0006886|GO:0040029|GO:0010821|GO:0007249|GO:0006417|GO:0035196|GO:0044822|GO:1903214|GO:0006351|GO:0035194|GO:0006355|GO:1903533|GO:1903506|GO:0035195|GO:0070585 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|positive regulation of cellular protein localization|protein binding|regulation of metabolic process|regulation of cellular localization|cellular aromatic compound metabolic process|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|negative regulation of biosynthetic process|positive regulation of intracellular transport|gene silencing|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|establishment of localization in cell|positive regulation of intracellular protein transport|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|establishment of protein localization to organelle|gene silencing by RNA|negative regulation of gene expression|mitochondrion organization|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|negative regulation of cellular protein metabolic process|response to dsRNA|regulation of establishment of protein localization|intracellular transport|nuclear lumen|nucleoplasm|cellular protein localization|response to organic cyclic compound|cellular amide metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|gene expression|cellular response to organic substance|protein targeting to mitochondrion|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of cellular protein localization|RNA metabolic process|nucleus|posttranscriptional gene silencing|positive regulation of organelle organization|peptide biosynthetic process|protein localization to organelle|regulation of intracellular protein transport|RNA processing|RNA biosynthetic process|negative regulation of translation|mitochondrial transport|cellular response to dsRNA|regulation of RNA biosynthetic process|protein targeting|establishment of protein localization to mitochondrion|posttranscriptional regulation of gene expression|positive regulation of mitochondrion organization|cellular response to organic cyclic compound|cytosolic transport|translation|intracellular protein transport|regulation of gene expression, epigenetic|regulation of mitochondrion organization|I-kappaB kinase/NF-kappaB signaling|regulation of translation|production of miRNAs involved in gene silencing by miRNA|poly(A) RNA binding|regulation of protein targeting to mitochondrion|transcription, DNA-templated|posttranscriptional gene silencing by RNA|regulation of transcription, DNA-templated|regulation of protein targeting|regulation of nucleic acid-templated transcription|gene silencing by miRNA|protein localization to mitochondrion - - - - 1:37534449-37554302 885 995 827 373 373 337 11.2009457077121 11.4449734912592 9.43694411523179 4.22978288507761 3.87336309747454 3.99733706607749 10.694287771401 4.03349434954321 1.40673826369408 2.08204134509844e-12 7.0393275556703e-11 UP ENSG00000038382 TRIO trio Rho guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:12303] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0016740|GO:0005085|GO:0048856|GO:0019222|GO:0006935|GO:0048468|GO:0010941|GO:0007275|GO:0043168|GO:0001882|GO:0016772|GO:0010942|GO:0019899|GO:0005737|GO:0005088|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0000166|GO:0030030|GO:0048869|GO:0019538|GO:0010033|GO:0000902|GO:0005829|GO:0031175|GO:0007166|GO:0035639|GO:0043412|GO:0051345|GO:0001883|GO:0000904|GO:0036211|GO:0032549|GO:0070848|GO:0016301|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0017076|GO:0030154|GO:0048858|GO:0005089|GO:0043068|GO:1902531|GO:0016773|GO:0043067|GO:0097190|GO:0048666|GO:0030182|GO:0007411|GO:0043065|GO:0005524|GO:0071363|GO:0043087|GO:0030554|GO:0016310|GO:0038179|GO:0061564|GO:0043547|GO:0007167|GO:0042981|GO:0004672|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0006915|GO:0048011|GO:0007265|GO:0046578|GO:0007409|GO:0006468|GO:0048699|GO:0004674|GO:0007185|GO:0007169|GO:0035023|GO:0007266 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|transferase activity|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|chemotaxis|cell development|regulation of cell death|multicellular organism development|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cell death|enzyme binding|cytoplasm|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|nucleotide binding|cell projection organization|cellular developmental process|protein metabolic process|response to organic substance|cell morphogenesis|cytosol|neuron projection development|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|positive regulation of hydrolase activity|purine nucleoside binding|cell morphogenesis involved in differentiation|protein modification process|ribonucleoside binding|response to growth factor|kinase activity|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|regulation of programmed cell death|apoptotic signaling pathway|neuron development|neuron differentiation|axon guidance|positive regulation of apoptotic process|ATP binding|cellular response to growth factor stimulus|regulation of GTPase activity|adenyl nucleotide binding|phosphorylation|neurotrophin signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of apoptotic process|protein kinase activity|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|apoptotic process|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|axonogenesis|protein phosphorylation|generation of neurons|protein serine/threonine kinase activity|transmembrane receptor protein tyrosine phosphatase signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction - - - - 5:14143702-14532128 642 694 952 2053 2406 2224 1.64023071344265 1.61142227370932 2.19291015784959 4.69955207513658 5.04351694763276 5.32517223337309 1.81485438166719 5.02274708538081 -1.46862283614613 2.14508288606206e-12 7.23607960231602e-11 DOWN ENSG00000184445 KNTC1 kinetochore associated 1 [Source:HGNC Symbol;Acc:HGNC:17255] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0051726|GO:0007049|GO:0022402|GO:0051302|GO:0005874|GO:0000776|GO:0051128|GO:0022607|GO:0045786|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:1990423|GO:0051301|GO:0006996|GO:0005829|GO:0000075|GO:1903047|GO:0044770|GO:0000278|GO:0007346|GO:0010564|GO:0045930|GO:0005876|GO:0005694|GO:0006461|GO:0035556|GO:0033043|GO:0007067|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0000777|GO:0015629|GO:0007093|GO:0007088|GO:0000793|GO:0044772|GO:1901990|GO:0015630|GO:0005828|GO:1901987|GO:0007264|GO:0010458|GO:0000775|GO:0000779|GO:0007096 macromolecular complex|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|regulation of cell cycle|cell cycle|cell cycle process|regulation of cell division|microtubule|kinetochore|regulation of cellular component organization|cellular component assembly|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|RZZ complex|cell division|organelle organization|cytosol|cell cycle checkpoint|mitotic cell cycle process|cell cycle phase transition|mitotic cell cycle|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|spindle microtubule|chromosome|protein complex assembly|intracellular signal transduction|regulation of organelle organization|mitotic nuclear division|cytoskeleton|spindle pole|nucleus|spindle|condensed chromosome kinetochore|actin cytoskeleton|mitotic cell cycle checkpoint|regulation of mitotic nuclear division|condensed chromosome|mitotic cell cycle phase transition|regulation of mitotic cell cycle phase transition|microtubule cytoskeleton|kinetochore microtubule|regulation of cell cycle phase transition|small GTPase mediated signal transduction|exit from mitosis|chromosome, centromeric region|condensed chromosome, centromeric region|regulation of exit from mitosis - - - - 12:122527246-122626396 302 381 549 1200 1281 1253 1.50123189912715 1.72125737995666 2.46052350269995 5.34465624734503 5.22465998249784 5.83741921555448 1.89433759392792 5.46891181513245 -1.52956033971298 2.14394634579007e-12 7.23607960231602e-11 DOWN ENSG00000153157 SYCP2L synaptonemal complex protein 2 like [Source:HGNC Symbol;Acc:HGNC:21537] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0031981|GO:0005654|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nuclear lumen|nucleoplasm|nucleus - - - - 6:10886831-10979320 9 9 40 164 172 243 0.127403481490481 0.115792704296477 0.510517376728998 2.08007589282783 1.99771346101412 3.22383052082192 0.251237854171985 2.43387329155462 -3.27612830518296 2.1983571393466e-12 7.40742144899023e-11 DOWN ENSG00000170577 SIX2 SIX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10888] GO:0040011|GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0008284|GO:0042127|GO:0048565|GO:0035988|GO:0045595|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0072028|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0007389|GO:0001763|GO:0007423|GO:0005635|GO:0006928|GO:0009887|GO:0032403|GO:0048729|GO:0048598|GO:0072006|GO:0048568|GO:0045184|GO:0006139|GO:0008104|GO:0001704|GO:0016477|GO:0030278|GO:0001503|GO:0051649|GO:0008134|GO:0031965|GO:0060688|GO:0048869|GO:0044249|GO:0019827|GO:0031323|GO:0072089|GO:0000982|GO:0000902|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0051216|GO:0055123|GO:0002009|GO:0072594|GO:0072164|GO:0061005|GO:0001655|GO:0043583|GO:0072273|GO:0007498|GO:0072210|GO:0002064|GO:0009798|GO:0072038|GO:0051252|GO:0048754|GO:0060795|GO:0015031|GO:0061138|GO:0000904|GO:0009790|GO:0001656|GO:0010628|GO:0042474|GO:0007369|GO:0046907|GO:2000027|GO:0072001|GO:0032330|GO:0097168|GO:0003002|GO:0001707|GO:0060485|GO:0031981|GO:1902732|GO:0090189|GO:0001708|GO:0072077|GO:0005654|GO:0035019|GO:0061326|GO:0034613|GO:0060993|GO:0060429|GO:0072073|GO:0072161|GO:0010467|GO:0017038|GO:0048562|GO:0060562|GO:0048701|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0001228|GO:0001823|GO:0061035|GO:0048566|GO:0048546|GO:0016070|GO:0010557|GO:0005634|GO:0048332|GO:0006606|GO:0045165|GO:0048706|GO:0000975|GO:0045893|GO:0048863|GO:0033365|GO:0009792|GO:0051169|GO:0001657|GO:0030855|GO:0002062|GO:0032774|GO:0043565|GO:0048333|GO:2001141|GO:0072078|GO:0001077|GO:0072163|GO:0001658|GO:0006605|GO:0003690|GO:0048557|GO:0003382|GO:0006886|GO:0042471|GO:0061333|GO:2001012|GO:0009948|GO:0072080|GO:0009952|GO:0048704|GO:0048762|GO:0001710|GO:0007501|GO:0003338|GO:0072283|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006913|GO:0060231|GO:0006357|GO:1903506|GO:0044212|GO:0003337|GO:0060675|GO:0043009|GO:0034504|GO:0051170|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|cell|membrane|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|digestive tract development|chondrocyte proliferation|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|transport|tube development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|nephron morphogenesis|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|morphogenesis of a branching structure|sensory organ development|nuclear envelope|movement of cell or subcellular component|organ morphogenesis|protein complex binding|tissue morphogenesis|embryonic morphogenesis|nephron development|embryonic organ development|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|formation of primary germ layer|cell migration|regulation of ossification|ossification|establishment of localization in cell|transcription factor binding|nuclear membrane|regulation of morphogenesis of a branching structure|cellular developmental process|cellular biosynthetic process|stem cell population maintenance|regulation of cellular metabolic process|stem cell proliferation|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|cell morphogenesis|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|digestive system development|morphogenesis of an epithelium|establishment of protein localization to organelle|mesonephric tubule development|cell differentiation involved in kidney development|urogenital system development|ear development|metanephric nephron morphogenesis|mesoderm development|metanephric nephron development|epithelial cell development|axis specification|mesenchymal stem cell maintenance involved in nephron morphogenesis|regulation of RNA metabolic process|branching morphogenesis of an epithelial tube|cell fate commitment involved in formation of primary germ layer|protein transport|morphogenesis of a branching epithelium|cell morphogenesis involved in differentiation|embryo development|metanephros development|positive regulation of gene expression|middle ear morphogenesis|gastrulation|intracellular transport|regulation of organ morphogenesis|renal system development|regulation of chondrocyte differentiation|mesenchymal stem cell proliferation|regionalization|mesoderm formation|mesenchyme development|nuclear lumen|positive regulation of chondrocyte proliferation|regulation of branching involved in ureteric bud morphogenesis|cell fate specification|renal vesicle morphogenesis|nucleoplasm|somatic stem cell population maintenance|renal tubule development|cellular protein localization|kidney morphogenesis|epithelium development|kidney epithelium development|mesenchymal cell differentiation involved in kidney development|gene expression|protein import|embryonic organ morphogenesis|epithelial tube morphogenesis|embryonic cranial skeleton morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|mesonephros development|regulation of cartilage development|embryonic digestive tract development|digestive tract morphogenesis|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|mesoderm morphogenesis|protein import into nucleus|cell fate commitment|embryonic skeletal system development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|stem cell differentiation|protein localization to organelle|embryo development ending in birth or egg hatching|nuclear transport|ureteric bud development|epithelial cell differentiation|chondrocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|mesodermal cell differentiation|regulation of RNA biosynthetic process|nephron tubule morphogenesis|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|mesonephric epithelium development|branching involved in ureteric bud morphogenesis|protein targeting|double-stranded DNA binding|embryonic digestive tract morphogenesis|epithelial cell morphogenesis|intracellular protein transport|ear morphogenesis|renal tubule morphogenesis|mesenchymal cell differentiation involved in renal system development|anterior/posterior axis specification|nephron tubule development|anterior/posterior pattern specification|embryonic skeletal system morphogenesis|mesenchymal cell differentiation|mesodermal cell fate commitment|mesodermal cell fate specification|metanephros morphogenesis|metanephric renal vesicle morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|mesenchymal to epithelial transition|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|mesenchymal to epithelial transition involved in metanephros morphogenesis|ureteric bud morphogenesis|chordate embryonic development|protein localization to nucleus|nuclear import|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 2:45005161-45009430 283 306 277 90 95 96 9.07871160911099 8.92150314566678 8.01183062983689 2.58688634012652 2.50050958966314 2.88626178708179 8.67068179487155 2.65788590562382 1.70586626445792 2.20965905766492e-12 7.43710952734255e-11 UP ENSG00000155330 C16orf87 chromosome 16 open reading frame 87 [Source:HGNC Symbol;Acc:HGNC:33754] GO:0005488|GO:0005515 binding|protein binding - - - - 16:46796607-46831411 560 605 606 225 251 220 4.44088010734771 4.36029688144562 4.33279128752268 1.59867835761743 1.63313823071611 1.63505576441799 4.37798942543867 1.62229078425051 1.43223603414282 2.23444194823684e-12 7.51205291921875e-11 UP ENSG00000184995 IFNE interferon, epsilon [Source:HGNC Symbol;Acc:HGNC:18163] GO:0032502|GO:0002376|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0051707|GO:0007155|GO:0009607|GO:0009605|GO:0009893|GO:0005615|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0002250|GO:0016337|GO:0002286|GO:0006959|GO:0070661|GO:0007275|GO:0048513|GO:0070489|GO:0005102|GO:0006952|GO:0031325|GO:0098542|GO:0098609|GO:0032403|GO:0009615|GO:0001775|GO:0009966|GO:0002263|GO:0002323|GO:0010646|GO:0009617|GO:0046649|GO:0007154|GO:0007165|GO:0002366|GO:0051607|GO:0048869|GO:0019538|GO:0010033|GO:0031323|GO:0032268|GO:0042113|GO:0005126|GO:0030101|GO:0032943|GO:0007166|GO:0043412|GO:0030097|GO:0034097|GO:0030098|GO:0005125|GO:0036211|GO:0043331|GO:0007159|GO:0051247|GO:0005132|GO:0032270|GO:0042110|GO:0014070|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:0051246|GO:0042742|GO:0046651|GO:0030154|GO:1902531|GO:0002521|GO:0019221|GO:0031401|GO:0030183|GO:0016310|GO:0070486|GO:0071345|GO:0042100|GO:0043330|GO:0006464|GO:0007259|GO:0006468|GO:0046425|GO:0042325|GO:0001932|GO:0018193|GO:0001934|GO:0071593|GO:0042327|GO:0033138|GO:0042501|GO:0018105|GO:0033135|GO:0033141 developmental process|immune system process|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|response to other organism|cell adhesion|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|extracellular space|immune system development|protein binding|anatomical structure development|regulation of metabolic process|adaptive immune response|single organismal cell-cell adhesion|T cell activation involved in immune response|humoral immune response|leukocyte proliferation|multicellular organism development|animal organ development|T cell aggregation|receptor binding|defense response|positive regulation of cellular metabolic process|defense response to other organism|cell-cell adhesion|protein complex binding|response to virus|cell activation|regulation of signal transduction|cell activation involved in immune response|natural killer cell activation involved in immune response|regulation of cell communication|response to bacterium|lymphocyte activation|cell communication|signal transduction|leukocyte activation involved in immune response|defense response to virus|cellular developmental process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of cellular protein metabolic process|B cell activation|cytokine receptor binding|natural killer cell activation|mononuclear cell proliferation|cell surface receptor signaling pathway|macromolecule modification|hemopoiesis|response to cytokine|lymphocyte differentiation|cytokine activity|protein modification process|response to dsRNA|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|type I interferon receptor binding|positive regulation of cellular protein metabolic process|T cell activation|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of protein metabolic process|defense response to bacterium|lymphocyte proliferation|cell differentiation|regulation of intracellular signal transduction|leukocyte differentiation|cytokine-mediated signaling pathway|positive regulation of protein modification process|B cell differentiation|phosphorylation|leukocyte aggregation|cellular response to cytokine stimulus|B cell proliferation|response to exogenous dsRNA|cellular protein modification process|JAK-STAT cascade|protein phosphorylation|regulation of JAK-STAT cascade|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|lymphocyte aggregation|positive regulation of phosphorylation|positive regulation of peptidyl-serine phosphorylation|serine phosphorylation of STAT protein|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-serine phosphorylation of STAT protein K05442 interferon epsilon[-] hsa04060|hsa04630|hsa04622 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|RIG-I-like receptor signaling pathway - Homo sapiens (human) 9:21480839-21482313 12 23 21 90 113 130 0.575504417848731 1.00246669320439 0.908003876443468 3.86717585083321 4.44630289554854 5.84285061041314 0.82865832916553 4.71877645226496 -2.50956354658671 2.32949574891609e-12 7.82280833387413e-11 DOWN ENSG00000109189 USP46 ubiquitin specific peptidase 46 [Source:HGNC Symbol;Acc:HGNC:20075] GO:0007610|GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0007631|GO:0050794|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0044708|GO:0009605|GO:0016787|GO:0005515|GO:0050804|GO:0030534|GO:0006952|GO:0008343|GO:0060004|GO:0008233|GO:0007267|GO:0001662|GO:0010646|GO:0007154|GO:0033555|GO:0019538|GO:0010033|GO:0036459|GO:0043412|GO:0030163|GO:0042596|GO:0044265|GO:0048149|GO:0036211|GO:0006508|GO:0060013|GO:0044267|GO:0032228|GO:0097305|GO:0044257|GO:0045471|GO:0051603|GO:0070646|GO:0004843|GO:0008234|GO:0006464|GO:0019941|GO:0016579|GO:0007268|GO:0006511|GO:0007270|GO:0051932 behavior|signaling|cellular process|metabolic process|response to stimulus|binding|catalytic activity|feeding behavior|regulation of cellular process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|single-organism behavior|response to external stimulus|hydrolase activity|protein binding|modulation of synaptic transmission|adult behavior|defense response|adult feeding behavior|reflex|peptidase activity|cell-cell signaling|behavioral fear response|regulation of cell communication|cell communication|multicellular organismal response to stress|protein metabolic process|response to organic substance|thiol-dependent ubiquitinyl hydrolase activity|macromolecule modification|protein catabolic process|fear response|cellular macromolecule catabolic process|behavioral response to ethanol|protein modification process|proteolysis|righting reflex|cellular protein metabolic process|regulation of synaptic transmission, GABAergic|response to alcohol|cellular protein catabolic process|response to ethanol|proteolysis involved in cellular protein catabolic process|protein modification by small protein removal|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|modification-dependent protein catabolic process|protein deubiquitination|synaptic transmission|ubiquitin-dependent protein catabolic process|neuron-neuron synaptic transmission|synaptic transmission, GABAergic - - - - 4:52590972-52659335 197 270 286 693 820 885 0.871327542037332 1.08532305141929 1.14050244685699 2.7462905070064 2.97575637226578 3.66849361603966 1.0323843467712 3.13018016510395 -1.60026552509205 2.35385185257318e-12 7.89571833783369e-11 DOWN ENSG00000164610 RP9 retinitis pigmentosa 9 (autosomal dominant) [Source:HGNC Symbol;Acc:HGNC:10288] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006725|GO:1901360|GO:0003676|GO:0050877|GO:0034641|GO:0030867|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0005785|GO:0005783|GO:0046872|GO:0003723|GO:0005791|GO:0010467|GO:0050890|GO:0016070|GO:0005634|GO:0006396|GO:0046914|GO:0044822|GO:0008380|GO:0008270 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|neurological system process|cellular nitrogen compound metabolic process|rough endoplasmic reticulum membrane|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|signal recognition particle receptor complex|endoplasmic reticulum|metal ion binding|RNA binding|rough endoplasmic reticulum|gene expression|cognition|RNA metabolic process|nucleus|RNA processing|transition metal ion binding|poly(A) RNA binding|RNA splicing|zinc ion binding K19604 retinitis pigmentosa 9 protein[-] hsa03040 Spliceosome - Homo sapiens (human) 7:33094797-33109401 595 571 554 210 232 150 17.0329521052815 14.8555564191852 14.2987075391449 5.38629308779886 5.44915283880066 4.02433472608861 15.3957386878705 4.95326021756271 1.63608077009406 2.39430574888632e-12 8.02240222528085e-11 UP ENSG00000104899 AMH anti-Mullerian hormone [Source:HGNC Symbol;Acc:HGNC:464] GO:0032502|GO:0040007|GO:0000003|GO:0023052|GO:0048511|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0050794|GO:0006807|GO:0044702|GO:0071704|GO:0042698|GO:0019953|GO:0001546|GO:0044237|GO:0003006|GO:0009653|GO:0009893|GO:0032504|GO:0009058|GO:0005615|GO:0050793|GO:0022602|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0022605|GO:0007530|GO:0060033|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0048608|GO:0001541|GO:0007267|GO:2000194|GO:0007548|GO:0042493|GO:0006139|GO:0008406|GO:0007154|GO:0007276|GO:0001880|GO:0048869|GO:0044249|GO:0010033|GO:0007281|GO:0031323|GO:0051090|GO:0007568|GO:2000195|GO:0010468|GO:0005126|GO:0034645|GO:0008585|GO:0046661|GO:0061458|GO:0001655|GO:0007498|GO:2000354|GO:0051252|GO:0005179|GO:0048477|GO:0046545|GO:0010628|GO:0051091|GO:0060485|GO:2000355|GO:0007506|GO:0014070|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0008083|GO:0007292|GO:0010557|GO:0045893|GO:0032774|GO:2001141|GO:0051092|GO:0005160|GO:0006351|GO:0006355|GO:1903506 developmental process|growth|reproduction|signaling|rhythmic process|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|regulation of cellular process|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ovulation cycle|sexual reproduction|preantral ovarian follicle growth|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|extracellular space|regulation of developmental process|ovulation cycle process|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|oogenesis stage|sex determination|anatomical structure regression|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|reproductive structure development|ovarian follicle development|cell-cell signaling|regulation of female gonad development|sex differentiation|response to drug|nucleobase-containing compound metabolic process|gonad development|cell communication|gamete generation|Mullerian duct regression|cellular developmental process|cellular biosynthetic process|response to organic substance|germ cell development|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|aging|negative regulation of female gonad development|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|female gonad development|male sex differentiation|reproductive system development|urogenital system development|mesoderm development|regulation of ovarian follicle development|regulation of RNA metabolic process|hormone activity|oogenesis|development of primary female sexual characteristics|positive regulation of gene expression|positive regulation of sequence-specific DNA binding transcription factor activity|mesenchyme development|negative regulation of ovarian follicle development|gonadal mesoderm development|response to organic cyclic compound|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|growth factor activity|female gamete generation|positive regulation of macromolecule biosynthetic process|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|positive regulation of NF-kappaB transcription factor activity|transforming growth factor beta receptor binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription K04665 anti-mullerian hormone[-] hsa04060|hsa04024|hsa04390|hsa04350 Cytokine-cytokine receptor interaction - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human) 19:2249309-2252073 127 87 48 7 12 6 2.31476248146993 1.44113004522982 0.788786330195442 0.114309175249116 0.179455842377625 0.102495488022858 1.5148929522984 0.132086835216533 3.51965726250954 2.42192551487038e-12 8.0995240026574e-11 UP ENSG00000240230 COX19 COX19 cytochrome c oxidase assembly factor [Source:HGNC Symbol;Acc:HGNC:28074] GO:0005623|GO:0009987|GO:0008152|GO:0043229|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0015980|GO:0022607|GO:0043231|GO:0005737|GO:0005758|GO:0006091|GO:0006996|GO:0055114|GO:0005740|GO:0005829|GO:0007005|GO:0005739|GO:0006461|GO:0045333|GO:0009060|GO:0034622|GO:0043623|GO:0033108|GO:0033617|GO:0017004|GO:0008535 cell|cellular process|metabolic process|intracellular organelle|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|energy derivation by oxidation of organic compounds|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|mitochondrial intermembrane space|generation of precursor metabolites and energy|organelle organization|oxidation-reduction process|mitochondrial envelope|cytosol|mitochondrion organization|mitochondrion|protein complex assembly|cellular respiration|aerobic respiration|cellular macromolecular complex assembly|cellular protein complex assembly|mitochondrial respiratory chain complex assembly|mitochondrial respiratory chain complex IV assembly|cytochrome complex assembly|respiratory chain complex IV assembly - - - - 7:898778-975599 1083 1201 734 305 325 362 12.503344807186 12.6014592901805 7.64026255838427 3.15496765200883 3.07857221740883 3.91683891741492 10.9150222185836 3.38345959561086 1.68974400160069 2.42274902337143e-12 8.0995240026574e-11 UP ENSG00000171435 KSR2 kinase suppressor of ras 2 [Source:HGNC Symbol;Acc:HGNC:18610] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0005622|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0000166|GO:0019538|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|intracellular|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|cytoplasm|cell communication|signal transduction|nucleotide binding|protein metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity K18529 kinase suppressor of Ras 2[2.7.11.1] hsa04014 Ras signaling pathway - Homo sapiens (human) 12:117453012-117968983 10 7 5 48 79 87 0.021549342843092 0.013710746381043 0.0097141386121953 0.0926807424050687 0.139684951660374 0.175711827180279 0.0149914092787768 0.136025840415241 -3.18167282548733 2.43855960629121e-12 8.14326157563958e-11 DOWN ENSG00000136261 BZW2 basic leucine zipper and W2 domains 2 [Source:HGNC Symbol;Acc:HGNC:18808] GO:0032502|GO:0016020|GO:0009987|GO:0005488|GO:0005515|GO:0048856|GO:0007275|GO:0048869|GO:0007399|GO:0030154 developmental process|membrane|cellular process|binding|protein binding|anatomical structure development|multicellular organism development|cellular developmental process|nervous system development|cell differentiation - - - - 7:16646131-16706523 895 986 1380 3294 3759 2773 9.39170560018301 9.40325481371877 13.0561403814623 30.970104655628 32.3639605077822 27.27094361516 10.6170335984547 30.2016695928567 -1.50824757293704 2.50993478109523e-12 8.37224502288456e-11 DOWN ENSG00000122507 BBS9 Bardet-Biedl syndrome 9 [Source:HGNC Symbol;Acc:HGNC:30000] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0042995|GO:0043229|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0031090|GO:0006810|GO:0050877|GO:0060170|GO:0022607|GO:0005737|GO:0045184|GO:0072372|GO:0008104|GO:0035869|GO:0030030|GO:0031253|GO:0048869|GO:0034464|GO:0006996|GO:0000902|GO:0005829|GO:0005813|GO:0005815|GO:0015031|GO:0044782|GO:0007600|GO:0030031|GO:0034613|GO:0070925|GO:0042384|GO:0032990|GO:0030154|GO:0048858|GO:0005856|GO:0031513|GO:0060271|GO:0050953|GO:0045444|GO:0033365|GO:0015630|GO:0034451|GO:0000242|GO:0061512|GO:0007601 developmental process|macromolecular complex|cell|membrane|cellular process|response to stimulus|binding|cell projection|intracellular organelle|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|organelle membrane|transport|neurological system process|ciliary membrane|cellular component assembly|cytoplasm|establishment of protein localization|primary cilium|protein localization|ciliary transition zone|cell projection organization|cell projection membrane|cellular developmental process|BBSome|organelle organization|cell morphogenesis|cytosol|centrosome|microtubule organizing center|protein transport|cilium organization|sensory perception|cell projection assembly|cellular protein localization|organelle assembly|cilium assembly|cell part morphogenesis|cell differentiation|cell projection morphogenesis|cytoskeleton|nonmotile primary cilium|cilium morphogenesis|sensory perception of light stimulus|fat cell differentiation|protein localization to organelle|microtubule cytoskeleton|centriolar satellite|pericentriolar material|protein localization to cilium|visual perception - - - - 7:33129244-33606068 16 12 41 131 179 213 0.112326644315159 0.0765628845721352 0.259507742093554 0.823997931673396 1.03104827250211 1.40141193769492 0.149465756993616 1.08548604729014 -2.86045427975654 2.51317072041181e-12 8.37368288919354e-11 DOWN ENSG00000110851 PRDM4 PR domain containing 4 [Source:HGNC Symbol;Acc:HGNC:9348] GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0045926|GO:0016043|GO:0043227|GO:0040008|GO:0009605|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:1901360|GO:0009991|GO:0016570|GO:0003676|GO:0005102|GO:0034641|GO:0046483|GO:0051128|GO:0045786|GO:0043231|GO:0043169|GO:0019899|GO:0030308|GO:0005737|GO:0031668|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0019538|GO:0010033|GO:0001558|GO:0031323|GO:0006996|GO:0007584|GO:0051276|GO:0003677|GO:0008168|GO:0010468|GO:0005126|GO:0034645|GO:0046872|GO:0007166|GO:0043412|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0031670|GO:0031981|GO:1990234|GO:0070848|GO:0005654|GO:0044267|GO:0010467|GO:0071310|GO:0009059|GO:1990226|GO:0035097|GO:0031669|GO:0016070|GO:0031667|GO:0005634|GO:0032813|GO:0032774|GO:2001141|GO:0071363|GO:0038179|GO:0034969|GO:0007167|GO:0046914|GO:0016568|GO:0006464|GO:0018216|GO:0006351|GO:0006355|GO:0048011|GO:0006366|GO:0043985|GO:1903506|GO:0018193|GO:0008270|GO:0007169|GO:0005123 growth|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|methylation|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|negative regulation of growth|cellular component organization|membrane-bounded organelle|regulation of growth|response to external stimulus|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|response to extracellular stimulus|histone modification|nucleic acid binding|receptor binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|enzyme binding|negative regulation of cell growth|cytoplasm|cellular response to extracellular stimulus|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|organelle organization|response to nutrient|chromosome organization|DNA binding|methyltransferase activity|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|protein modification process|cellular response to nutrient|nuclear lumen|transferase complex|response to growth factor|nucleoplasm|cellular protein metabolic process|gene expression|cellular response to organic substance|macromolecule biosynthetic process|histone methyltransferase binding|histone methyltransferase complex|cellular response to nutrient levels|RNA metabolic process|response to nutrient levels|nucleus|tumor necrosis factor receptor superfamily binding|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|neurotrophin signaling pathway|histone arginine methylation|enzyme linked receptor protein signaling pathway|transition metal ion binding|chromatin modification|cellular protein modification process|peptidyl-arginine methylation|transcription, DNA-templated|regulation of transcription, DNA-templated|neurotrophin TRK receptor signaling pathway|transcription from RNA polymerase II promoter|histone H4-R3 methylation|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|zinc ion binding|transmembrane receptor protein tyrosine kinase signaling pathway|death receptor binding K12463 PR domain zinc finger protein 4[-] hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) 12:107732866-107761272 1429 1479 928 416 471 320 14.2250116591367 13.3803928930809 8.32880622583931 3.71032043758438 3.84688735693731 2.98538110855405 11.9780702593523 3.51419630102525 1.76912881297825 2.54756317294747e-12 8.47881281663028e-11 UP ENSG00000136059 VILL villin-like [Source:HGNC Symbol;Acc:HGNC:30906] GO:0005198|GO:0005623|GO:0009987|GO:0005488|GO:0005200|GO:0048523|GO:0050794|GO:0043229|GO:0016043|GO:0005622|GO:0005515|GO:0032535|GO:0051128|GO:0022607|GO:0032970|GO:0008092|GO:0030029|GO:0043254|GO:0006996|GO:0031333|GO:0032956|GO:0007010|GO:0003779|GO:0043242|GO:0006461|GO:0043244|GO:0030036|GO:0033043|GO:0030832|GO:0005856|GO:0015629|GO:0043241|GO:0034622|GO:0043623|GO:0008064|GO:0051494|GO:0051493|GO:0032272|GO:1901879|GO:0007015|GO:0030833|GO:0051258|GO:0043624|GO:0030837|GO:0030834|GO:0008154|GO:0030835|GO:0051693|GO:0030042|GO:0030041|GO:0051261 structural molecule activity|cell|cellular process|binding|structural constituent of cytoskeleton|negative regulation of cellular process|regulation of cellular process|intracellular organelle|cellular component organization|intracellular|protein binding|regulation of cellular component size|regulation of cellular component organization|cellular component assembly|regulation of actin filament-based process|cytoskeletal protein binding|actin filament-based process|regulation of protein complex assembly|organelle organization|negative regulation of protein complex assembly|regulation of actin cytoskeleton organization|cytoskeleton organization|actin binding|negative regulation of protein complex disassembly|protein complex assembly|regulation of protein complex disassembly|actin cytoskeleton organization|regulation of organelle organization|regulation of actin filament length|cytoskeleton|actin cytoskeleton|protein complex disassembly|cellular macromolecular complex assembly|cellular protein complex assembly|regulation of actin polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|regulation of protein depolymerization|actin filament organization|regulation of actin filament polymerization|protein polymerization|cellular protein complex disassembly|negative regulation of actin filament polymerization|regulation of actin filament depolymerization|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|actin filament capping|actin filament depolymerization|actin filament polymerization|protein depolymerization - - - - 3:37988059-38007188 40 23 99 379 358 520 0.268706081654739 0.140421497861013 0.599606863892715 2.28115305416332 1.97318943850546 3.27377864370256 0.336244814469489 2.50937371212378 -2.89974341833195 2.56802167253704e-12 8.53738519063705e-11 DOWN ENSG00000143797 MBOAT2 membrane bound O-acyltransferase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25193] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0034641|GO:0044281|GO:0019637|GO:0043231|GO:0016746|GO:0005737|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0008654|GO:0046486|GO:0006066|GO:0009308|GO:0046470|GO:0016747|GO:0006796|GO:0008610|GO:0006644|GO:0036152|GO:0071617|GO:0046474|GO:0006576|GO:0036151|GO:0006650|GO:0008374|GO:0042171|GO:0003841 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|phospholipid biosynthetic process|glycerolipid metabolic process|alcohol metabolic process|amine metabolic process|phosphatidylcholine metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|phosphate-containing compound metabolic process|lipid biosynthetic process|phospholipid metabolic process|phosphatidylethanolamine acyl-chain remodeling|lysophospholipid acyltransferase activity|glycerophospholipid biosynthetic process|cellular biogenic amine metabolic process|phosphatidylcholine acyl-chain remodeling|glycerophospholipid metabolic process|O-acyltransferase activity|lysophosphatidic acid acyltransferase activity|1-acylglycerol-3-phosphate O-acyltransferase activity K13517 lysophospholipid acyltransferase 1/2 [EC:2.3.1.51 2.3.1.-][-] hsa01100|hsa00564|hsa00561 Metabolic pathways - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human) 2:8852690-9003813 229 238 607 1468 1658 1737 1.46250884037939 1.38139923210713 3.49514652966072 8.40013992727005 8.68790850220017 10.3966048803655 2.11301820071575 9.16155110327857 -2.11628668142764 2.62090216387054e-12 8.70349423806353e-11 DOWN ENSG00000085382 HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:21033] GO:0040011|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0048870|GO:0016043|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0006928|GO:0006139|GO:0007154|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0019787|GO:2000145|GO:0044249|GO:0019538|GO:0031323|GO:0010256|GO:0005794|GO:0006996|GO:0061025|GO:0010468|GO:0034645|GO:0043412|GO:0007030|GO:0030163|GO:0004842|GO:0051252|GO:0044265|GO:0030334|GO:0036211|GO:0006508|GO:0035556|GO:0005795|GO:0044267|GO:0010467|GO:0000139|GO:0009059|GO:0051020|GO:0016070|GO:0044257|GO:0032774|GO:2001141|GO:0031985|GO:0051603|GO:0031267|GO:0032580|GO:0007264|GO:0006464|GO:0006351|GO:0006355|GO:0007265|GO:0017016|GO:0019941|GO:1903506|GO:0032446|GO:0017137|GO:0006511|GO:0017048|GO:0016601|GO:0048365|GO:0042787|GO:0016567|GO:0000209|GO:0070936 locomotion|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cell motility|cellular component organization|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|movement of cell or subcellular component|nucleobase-containing compound metabolic process|cell communication|membrane organization|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|ubiquitin-like protein transferase activity|regulation of cell motility|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|membrane fusion|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|Golgi organization|protein catabolic process|ubiquitin-protein transferase activity|regulation of RNA metabolic process|cellular macromolecule catabolic process|regulation of cell migration|protein modification process|proteolysis|intracellular signal transduction|Golgi stack|cellular protein metabolic process|gene expression|Golgi membrane|macromolecule biosynthetic process|GTPase binding|RNA metabolic process|cellular protein catabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|Golgi cisterna|proteolysis involved in cellular protein catabolic process|small GTPase binding|Golgi cisterna membrane|small GTPase mediated signal transduction|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|Ras protein signal transduction|Ras GTPase binding|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|protein modification by small protein conjugation|Rab GTPase binding|ubiquitin-dependent protein catabolic process|Rho GTPase binding|Rac protein signal transduction|Rac GTPase binding|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination|protein K48-linked ubiquitination - - - - 6:104728093-104859919 54 46 86 287 250 288 0.22586395352694 0.174859028833798 0.324312853300017 1.07554964375279 0.857942868401332 1.1289434861812 0.241678611886918 1.02081199944511 -2.07855548490763 2.64338097743898e-12 8.76838841116259e-11 DOWN ENSG00000127928 GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:4411] GO:0032502|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0019898|GO:0042995|GO:0051606|GO:0050794|GO:0006950|GO:0009628|GO:0023051|GO:0009653|GO:0043227|GO:0071944|GO:0009605|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0031090|GO:0009898|GO:0048468|GO:0009314|GO:0098797|GO:0007275|GO:0048513|GO:0060170|GO:0033554|GO:0016817|GO:0009582|GO:0007267|GO:0007423|GO:0009887|GO:0031234|GO:0001917|GO:0098562|GO:0009966|GO:0072372|GO:0097381|GO:0019897|GO:0010646|GO:0008104|GO:0007154|GO:0001750|GO:0007165|GO:0005834|GO:0008219|GO:0001666|GO:0031253|GO:0048869|GO:0007186|GO:0001654|GO:0009583|GO:0008277|GO:0016818|GO:0071456|GO:0007602|GO:0022400|GO:0071478|GO:0071453|GO:0012501|GO:0007399|GO:0030154|GO:0009416|GO:0031513|GO:0048666|GO:0030182|GO:0042461|GO:0016056|GO:0009584|GO:0071482|GO:0007603|GO:0022008|GO:0016462|GO:0006915|GO:0048592|GO:0036294|GO:0048699|GO:0017111|GO:0001754|GO:0042462|GO:0010657|GO:0007268|GO:0003924|GO:0010659 developmental process|macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|cellular response to stimulus|extrinsic component of membrane|cell projection|detection of stimulus|regulation of cellular process|response to stress|response to abiotic stimulus|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|response to external stimulus|hydrolase activity|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|organelle membrane|cytoplasmic side of plasma membrane|cell development|response to radiation|plasma membrane protein complex|multicellular organism development|animal organ development|ciliary membrane|cellular response to stress|hydrolase activity, acting on acid anhydrides|detection of abiotic stimulus|cell-cell signaling|sensory organ development|organ morphogenesis|extrinsic component of cytoplasmic side of plasma membrane|photoreceptor inner segment|cytoplasmic side of membrane|regulation of signal transduction|primary cilium|photoreceptor disc membrane|extrinsic component of plasma membrane|regulation of cell communication|protein localization|cell communication|photoreceptor outer segment|signal transduction|heterotrimeric G-protein complex|cell death|response to hypoxia|cell projection membrane|cellular developmental process|G-protein coupled receptor signaling pathway|eye development|detection of light stimulus|regulation of G-protein coupled receptor protein signaling pathway|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cellular response to hypoxia|phototransduction|regulation of rhodopsin mediated signaling pathway|cellular response to radiation|cellular response to oxygen levels|programmed cell death|nervous system development|cell differentiation|response to light stimulus|nonmotile primary cilium|neuron development|neuron differentiation|photoreceptor cell development|rhodopsin mediated signaling pathway|detection of visible light|cellular response to light stimulus|phototransduction, visible light|neurogenesis|pyrophosphatase activity|apoptotic process|eye morphogenesis|cellular response to decreased oxygen levels|generation of neurons|nucleoside-triphosphatase activity|eye photoreceptor cell differentiation|eye photoreceptor cell development|muscle cell apoptotic process|synaptic transmission|GTPase activity|cardiac muscle cell apoptotic process K04548 guanine nucleotide-binding protein G(T) subunit gamma-T1[-] hsa05200|hsa04151|hsa04014|hsa04062|hsa05034|hsa04728|hsa04724|hsa04726|hsa04725|hsa04723|hsa04713|hsa05032|hsa04727|hsa04744 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Phototransduction - Homo sapiens (human) 7:93591573-93911265 2 2 3 37 36 32 0.0325511104225334 0.0295845844818543 0.0440176672372921 0.539575556634794 0.480751553486828 0.488132977240816 0.0353844540472266 0.502820029120813 -3.82885455361319 2.64781269371203e-12 8.77334075006426e-11 DOWN ENSG00000105879 CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:21225] GO:0040011|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0040017|GO:0016043|GO:0007155|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0042802|GO:0051272|GO:0016337|GO:0006810|GO:0051130|GO:0060627|GO:0003676|GO:0030155|GO:0051128|GO:2000147|GO:0045807|GO:0098609|GO:0043231|GO:0043169|GO:0006928|GO:0007162|GO:0051270|GO:0016477|GO:0019787|GO:0000151|GO:2000145|GO:0019538|GO:0016192|GO:0046872|GO:0043412|GO:0004842|GO:0030334|GO:0036211|GO:0031981|GO:1990234|GO:0030100|GO:0005654|GO:0044267|GO:0030335|GO:0005634|GO:0061630|GO:0016604|GO:0046914|GO:0006897|GO:0006464|GO:0016607|GO:0008270|GO:0032446|GO:0016567 locomotion|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|positive regulation of locomotion|cellular component organization|cell adhesion|membrane-bounded organelle|ligase activity|intracellular|protein binding|protein complex|transferase activity|identical protein binding|positive regulation of cellular component movement|single organismal cell-cell adhesion|transport|positive regulation of cellular component organization|regulation of vesicle-mediated transport|nucleic acid binding|regulation of cell adhesion|regulation of cellular component organization|positive regulation of cell motility|positive regulation of endocytosis|cell-cell adhesion|intracellular membrane-bounded organelle|cation binding|movement of cell or subcellular component|negative regulation of cell adhesion|regulation of cellular component movement|cell migration|ubiquitin-like protein transferase activity|ubiquitin ligase complex|regulation of cell motility|protein metabolic process|vesicle-mediated transport|metal ion binding|macromolecule modification|ubiquitin-protein transferase activity|regulation of cell migration|protein modification process|nuclear lumen|transferase complex|regulation of endocytosis|nucleoplasm|cellular protein metabolic process|positive regulation of cell migration|nucleus|ubiquitin protein ligase activity|nuclear body|transition metal ion binding|endocytosis|cellular protein modification process|nuclear speck|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 7:107743697-107761667 1449 1571 1208 561 559 513 11.5023757569002 11.3338013342506 8.64570579748825 3.99006532662007 3.64081887269219 3.81650644153786 10.4939609628797 3.81579688028337 1.45950304632503 2.70010615827689e-12 8.93669282141888e-11 UP ENSG00000112773 FAM46A family with sequence similarity 46 member A [Source:HGNC Symbol;Acc:HGNC:18345] GO:0008152|GO:0050896|GO:0005488|GO:0097159|GO:0006950|GO:0071704|GO:0009605|GO:0005515|GO:0019222|GO:0050817|GO:0003676|GO:0009611|GO:0050878|GO:0010468|GO:0030193|GO:0003723|GO:0007596|GO:0042060|GO:0007599|GO:0010467|GO:0044822|GO:0061041 metabolic process|response to stimulus|binding|organic cyclic compound binding|response to stress|organic substance metabolic process|response to external stimulus|protein binding|regulation of metabolic process|coagulation|nucleic acid binding|response to wounding|regulation of body fluid levels|regulation of gene expression|regulation of blood coagulation|RNA binding|blood coagulation|wound healing|hemostasis|gene expression|poly(A) RNA binding|regulation of wound healing - - - - 6:81491439-81752774 555 646 926 242 286 273 5.56864533508174 5.8907316301269 8.37687105486819 2.17555367165357 2.35445874655404 2.56712979065672 6.61208267335894 2.36571406962144 1.48282904941619 2.7033993286238e-12 8.93768367184219e-11 UP ENSG00000229001 ACTBP14 actin, beta pseudogene 14 [Source:HGNC Symbol;Acc:HGNC:45086] - - - - - - 10:69022778-69023866 58 35 12 0 0 0 3.76744300628124 2.06619467164858 0.702788451754419 0 0 0 2.17880870989475 0 Inf 2.72772128457656e-12 9.00811849886601e-11 UP ENSG00000219545 UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 [Source:HGNC Symbol;Acc:HGNC:48955] - - - - - - 7:7640711-8004059 17 13 25 99 103 102 0.296694720106897 0.206209067773445 0.393392036945712 1.54810757323821 1.47494574434622 1.66839186516952 0.298765274942018 1.56381506091798 -2.38798552686855 2.81047552183658e-12 9.27115317446512e-11 DOWN ENSG00000102543 CDADC1 cytidine and dCMP deaminase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20299] GO:0008152|GO:0005488|GO:0003824|GO:0043167|GO:0016787|GO:0043169|GO:0046872|GO:0046914|GO:0008270 metabolic process|binding|catalytic activity|ion binding|hydrolase activity|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 13:49247925-49293485 256 277 246 83 75 83 3.43292009612624 3.37585082475073 2.97421806655338 0.997241795419368 0.82519093567025 1.04311318177339 3.26099632914345 0.955181970954336 1.77146530594164 2.8166738009176e-12 9.28134433251591e-11 UP ENSG00000049246 PER3 period circadian clock 3 [Source:HGNC Symbol;Acc:HGNC:8847] GO:0007610|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0042752|GO:0009892|GO:0048523|GO:0007622|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0044237|GO:0050795|GO:0043227|GO:0044708|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0030431|GO:0032922|GO:0043231|GO:0019899|GO:0005737|GO:0009890|GO:0006139|GO:0044249|GO:0048512|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0045187|GO:0019900|GO:0010467|GO:0009059|GO:0042745|GO:0016070|GO:0005634|GO:0044389|GO:0022410|GO:0031625|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 behavior|cell|rhythmic process|cellular process|metabolic process|response to stimulus|binding|regulation of circadian rhythm|negative regulation of metabolic process|negative regulation of cellular process|rhythmic behavior|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|cellular metabolic process|regulation of behavior|membrane-bounded organelle|single-organism behavior|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|sleep|circadian regulation of gene expression|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|circadian behavior|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|regulation of circadian sleep/wake cycle, sleep|kinase binding|gene expression|macromolecule biosynthetic process|circadian sleep/wake cycle|RNA metabolic process|nucleus|ubiquitin-like protein ligase binding|circadian sleep/wake cycle process|ubiquitin protein ligase binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter K02633 period circadian protein[-] hsa05168|hsa04713|hsa04710 Herpes simplex infection - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Circadian rhythm - Homo sapiens (human) 1:7784320-7845177 39 83 85 291 332 506 0.212289984332573 0.410609965157417 0.417157949121686 1.4192550200519 1.4827764682653 2.58136346026545 0.346685966203892 1.82779831619422 -2.39840554586846 2.86235823443061e-12 9.42148210922727e-11 DOWN ENSG00000001036 FUCA2 fucosidase, alpha-L- 2, plasma [Source:HGNC Symbol;Acc:HGNC:4008] GO:0040011|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0040012|GO:0071704|GO:0009056|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0016787|GO:0005615|GO:0005515|GO:0016798|GO:0044281|GO:0031982|GO:0005975|GO:0009617|GO:0070062|GO:2000535|GO:0051701|GO:0005996|GO:0004553|GO:0016137|GO:0016139|GO:0015928|GO:0019318|GO:0030260|GO:0006004|GO:0004560 locomotion|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|regulation of locomotion|organic substance metabolic process|catabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|hydrolase activity|extracellular space|protein binding|hydrolase activity, acting on glycosyl bonds|small molecule metabolic process|vesicle|carbohydrate metabolic process|response to bacterium|extracellular exosome|regulation of entry of bacterium into host cell|interaction with host|monosaccharide metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|glycoside metabolic process|glycoside catabolic process|fucosidase activity|hexose metabolic process|entry into host cell|fucose metabolic process|alpha-L-fucosidase activity K01206 alpha-L-fucosidase[3.2.1.51] hsa00511 Other glycan degradation - Homo sapiens (human) 6:143494811-143511690 319 313 298 1259 1342 768 7.32630961856252 6.53310258941773 6.17058190147548 25.9070884825341 25.2880516744054 16.5304771020695 6.67666470315191 22.575205753003 -1.75753964050053 2.97697082624787e-12 9.77717129227765e-11 DOWN ENSG00000168005 C11orf84 chromosome 11 open reading frame 84 [Source:HGNC Symbol;Acc:HGNC:25115] - - - - - - 11:63813388-63827718 2064 2245 1869 817 936 646 47.006063278107 46.4665827881893 38.3767145471374 16.6710860685617 17.489922728263 13.788136119458 43.9497868711446 15.9830483054276 1.45931358224913 2.97669190533007e-12 9.77717129227765e-11 UP ENSG00000149948 HMGA2 high mobility group AT-hook 2 [Source:HGNC Symbol;Acc:HGNC:5009] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0051606|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0044702|GO:0071704|GO:0009628|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0023051|GO:0000989|GO:0009653|GO:0000785|GO:0016043|GO:0051707|GO:0045927|GO:0043227|GO:0040008|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0016787|GO:0009058|GO:0032993|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0048609|GO:0019222|GO:0016032|GO:0045137|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0040018|GO:0006281|GO:0035988|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0009314|GO:0006810|GO:0022402|GO:1901360|GO:2001022|GO:0010941|GO:0007275|GO:0051702|GO:0016570|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0016788|GO:0042769|GO:0032940|GO:0030900|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0007420|GO:0022607|GO:0010942|GO:0051098|GO:0045786|GO:0043231|GO:2001023|GO:0048608|GO:0046332|GO:0019899|GO:2000036|GO:0000981|GO:0007267|GO:0060322|GO:0032403|GO:0035264|GO:0009615|GO:0009966|GO:0048729|GO:0048598|GO:0007548|GO:2000683|GO:0090343|GO:0009890|GO:0046883|GO:0048639|GO:0045787|GO:0003682|GO:0019904|GO:0060548|GO:0042493|GO:0010646|GO:0006139|GO:0008406|GO:0007154|GO:0001704|GO:0044092|GO:0007276|GO:0007165|GO:0009968|GO:0048638|GO:0008134|GO:0061351|GO:0009725|GO:0040014|GO:0048525|GO:0008219|GO:0051301|GO:0010817|GO:0048869|GO:0044249|GO:0071141|GO:2000774|GO:0019827|GO:0019538|GO:0000792|GO:0050792|GO:0010033|GO:0031324|GO:0031323|GO:0021536|GO:2001038|GO:0048732|GO:2000685|GO:0006996|GO:0051090|GO:0072089|GO:0007568|GO:0050768|GO:0051276|GO:0000982|GO:0003131|GO:0000902|GO:0003677|GO:0010468|GO:0000075|GO:0034645|GO:2000772|GO:0051053|GO:0008584|GO:0051216|GO:0090068|GO:0045738|GO:0048232|GO:0051101|GO:0090276|GO:0051575|GO:2000736|GO:0051100|GO:0033993|GO:1903047|GO:0043412|GO:0046661|GO:0061458|GO:0007417|GO:0010629|GO:0016572|GO:0007498|GO:0043069|GO:0051252|GO:0006325|GO:0003906|GO:0044770|GO:0010721|GO:0006284|GO:0007492|GO:0007050|GO:0000904|GO:0009790|GO:0010628|GO:0006302|GO:0036211|GO:0000278|GO:0007369|GO:0070742|GO:0042886|GO:0019083|GO:0051091|GO:0021983|GO:0001707|GO:0051046|GO:0007569|GO:0039692|GO:0060485|GO:0035270|GO:0031981|GO:2001020|GO:0004518|GO:0007346|GO:0010564|GO:0071478|GO:0009914|GO:0001706|GO:0051099|GO:0045930|GO:0021846|GO:0005654|GO:0031491|GO:0006259|GO:0033143|GO:0005694|GO:0000228|GO:0016301|GO:0035019|GO:0033144|GO:0030325|GO:0006282|GO:0012501|GO:0014070|GO:0006796|GO:0010212|GO:0035501|GO:0035556|GO:0044267|GO:0007067|GO:0048864|GO:0010467|GO:0019079|GO:0007399|GO:0046903|GO:0019058|GO:0071310|GO:0001227|GO:1902532|GO:0035985|GO:0031328|GO:0035690|GO:0009059|GO:0030154|GO:0009755|GO:0001501|GO:0061448|GO:0001228|GO:0043068|GO:1902531|GO:0016070|GO:0016773|GO:0032870|GO:0035500|GO:0010557|GO:0005634|GO:0030261|GO:0090398|GO:0043067|GO:0048545|GO:0006974|GO:0048332|GO:0051960|GO:2000648|GO:0030522|GO:0060612|GO:0046546|GO:0072091|GO:0010948|GO:0031490|GO:0043401|GO:0002790|GO:0007283|GO:0006303|GO:0000975|GO:0045893|GO:0048863|GO:0045444|GO:2000677|GO:0004536|GO:0060613|GO:0010001|GO:0043065|GO:0071156|GO:0043566|GO:0001078|GO:0035404|GO:0045892|GO:0007093|GO:0000086|GO:0046782|GO:0035987|GO:0002062|GO:0032774|GO:0044772|GO:0043565|GO:0048333|GO:0045091|GO:2001141|GO:0014031|GO:0001077|GO:0016310|GO:0015833|GO:0045069|GO:0044774|GO:1902679|GO:0000077|GO:0043388|GO:0071383|GO:2000779|GO:0071407|GO:0031492|GO:0003690|GO:0030518|GO:1901990|GO:0045071|GO:0006333|GO:0008301|GO:0031052|GO:0004519|GO:0031497|GO:0042981|GO:0032897|GO:0043066|GO:0004672|GO:0016568|GO:0007095|GO:0048762|GO:1901987|GO:0071479|GO:0060123|GO:0090402|GO:0010165|GO:0022008|GO:0006464|GO:0050767|GO:0001837|GO:0071396|GO:0070828|GO:0071103|GO:0046879|GO:0045869|GO:0048708|GO:0006351|GO:0006915|GO:2000780|GO:0006355|GO:0044773|GO:1901991|GO:0071158|GO:0043392|GO:0004520|GO:0006323|GO:0045686|GO:0048710|GO:0045944|GO:0006366|GO:0030072|GO:0007259|GO:1903507|GO:0010389|GO:0044818|GO:0010972|GO:0006357|GO:0006468|GO:0048699|GO:0014013|GO:1903506|GO:0046425|GO:0045685|GO:1902750|GO:0044212|GO:2001033|GO:0031507|GO:0046426|GO:2000679|GO:0018193|GO:0042063|GO:0004674|GO:0035978|GO:1902749|GO:0006338|GO:0000122|GO:0043922|GO:2001032|GO:0071481|GO:0031572|GO:0048712|GO:0030252|GO:0035986|GO:0035497|GO:0001047|GO:0018105|GO:0003680|GO:0004677 developmental process|growth|macromolecular complex|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|detection of stimulus|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cellular component organization|response to other organism|positive regulation of growth|membrane-bounded organelle|regulation of growth|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|biosynthetic process|protein-DNA complex|regulation of developmental process|developmental growth|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|viral process|development of primary sexual characteristics|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|positive regulation of multicellular organism growth|DNA repair|chondrocyte proliferation|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|response to radiation|transport|cell cycle process|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|regulation of cell death|multicellular organism development|interaction with symbiont|histone modification|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|DNA damage response, detection of DNA damage|secretion by cell|forebrain development|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|brain development|cellular component assembly|positive regulation of cell death|regulation of binding|negative regulation of cell cycle|intracellular membrane-bounded organelle|regulation of response to drug|reproductive structure development|SMAD binding|enzyme binding|regulation of stem cell population maintenance|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cell-cell signaling|head development|protein complex binding|multicellular organism growth|response to virus|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|sex differentiation|regulation of cellular response to X-ray|positive regulation of cell aging|negative regulation of biosynthetic process|regulation of hormone secretion|positive regulation of developmental growth|positive regulation of cell cycle|chromatin binding|protein domain specific binding|negative regulation of cell death|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|gonad development|cell communication|formation of primary germ layer|negative regulation of molecular function|gamete generation|signal transduction|negative regulation of signal transduction|regulation of developmental growth|transcription factor binding|neural precursor cell proliferation|response to hormone|regulation of multicellular organism growth|negative regulation of viral process|cell death|cell division|regulation of hormone levels|cellular developmental process|cellular biosynthetic process|SMAD protein complex|positive regulation of cellular senescence|stem cell population maintenance|protein metabolic process|heterochromatin|regulation of viral process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|diencephalon development|regulation of cellular response to drug|gland development|positive regulation of cellular response to X-ray|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|stem cell proliferation|aging|negative regulation of neurogenesis|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|mesodermal-endodermal cell signaling|cell morphogenesis|DNA binding|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|regulation of cellular senescence|negative regulation of DNA metabolic process|male gonad development|cartilage development|positive regulation of cell cycle process|negative regulation of DNA repair|male gamete generation|regulation of DNA binding|regulation of peptide hormone secretion|5'-deoxyribose-5-phosphate lyase activity|regulation of stem cell differentiation|negative regulation of binding|response to lipid|mitotic cell cycle process|macromolecule modification|male sex differentiation|reproductive system development|central nervous system development|negative regulation of gene expression|histone phosphorylation|mesoderm development|negative regulation of programmed cell death|regulation of RNA metabolic process|chromatin organization|DNA-(apurinic or apyrimidinic site) lyase activity|cell cycle phase transition|negative regulation of cell development|base-excision repair|endoderm development|cell cycle arrest|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|double-strand break repair|protein modification process|mitotic cell cycle|gastrulation|C2H2 zinc finger domain binding|amide transport|viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|pituitary gland development|mesoderm formation|regulation of secretion|cell aging|single stranded viral RNA replication via double stranded DNA intermediate|mesenchyme development|endocrine system development|nuclear lumen|regulation of response to DNA damage stimulus|nuclease activity|regulation of mitotic cell cycle|regulation of cell cycle process|cellular response to radiation|hormone transport|endoderm formation|positive regulation of binding|negative regulation of mitotic cell cycle|cell proliferation in forebrain|nucleoplasm|nucleosome binding|DNA metabolic process|regulation of intracellular steroid hormone receptor signaling pathway|chromosome|nuclear chromosome|kinase activity|somatic stem cell population maintenance|negative regulation of intracellular steroid hormone receptor signaling pathway|adrenal gland development|regulation of DNA repair|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|response to ionizing radiation|MH1 domain binding|intracellular signal transduction|cellular protein metabolic process|mitotic nuclear division|stem cell development|gene expression|viral genome replication|nervous system development|secretion|viral life cycle|cellular response to organic substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|negative regulation of intracellular signal transduction|senescence-associated heterochromatin focus|positive regulation of cellular biosynthetic process|cellular response to drug|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|skeletal system development|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|MH2 domain binding|positive regulation of macromolecule biosynthetic process|nucleus|chromosome condensation|cellular senescence|regulation of programmed cell death|response to steroid hormone|cellular response to DNA damage stimulus|mesoderm morphogenesis|regulation of nervous system development|positive regulation of stem cell proliferation|intracellular receptor signaling pathway|adipose tissue development|development of primary male sexual characteristics|regulation of stem cell proliferation|negative regulation of cell cycle process|chromatin DNA binding|steroid hormone mediated signaling pathway|peptide secretion|spermatogenesis|double-strand break repair via nonhomologous end joining|regulatory region DNA binding|positive regulation of transcription, DNA-templated|stem cell differentiation|fat cell differentiation|regulation of transcription regulatory region DNA binding|deoxyribonuclease activity|fat pad development|glial cell differentiation|positive regulation of apoptotic process|regulation of cell cycle arrest|structure-specific DNA binding|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|histone-serine phosphorylation|negative regulation of transcription, DNA-templated|mitotic cell cycle checkpoint|G2/M transition of mitotic cell cycle|regulation of viral transcription|endodermal cell differentiation|chondrocyte differentiation|RNA biosynthetic process|mitotic cell cycle phase transition|sequence-specific DNA binding|mesodermal cell differentiation|regulation of single stranded viral RNA replication via double stranded DNA intermediate|regulation of RNA biosynthetic process|mesenchymal cell development|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|phosphorylation|peptide transport|regulation of viral genome replication|mitotic DNA integrity checkpoint|negative regulation of RNA biosynthetic process|DNA damage checkpoint|positive regulation of DNA binding|cellular response to steroid hormone stimulus|regulation of double-strand break repair|cellular response to organic cyclic compound|nucleosomal DNA binding|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|regulation of mitotic cell cycle phase transition|negative regulation of viral genome replication|chromatin assembly or disassembly|DNA binding, bending|chromosome breakage|endonuclease activity|chromatin assembly|regulation of apoptotic process|negative regulation of viral transcription|negative regulation of apoptotic process|protein kinase activity|chromatin modification|mitotic G2 DNA damage checkpoint|mesenchymal cell differentiation|regulation of cell cycle phase transition|cellular response to ionizing radiation|regulation of growth hormone secretion|oncogene-induced cell senescence|response to X-ray|neurogenesis|cellular protein modification process|regulation of neurogenesis|epithelial to mesenchymal transition|cellular response to lipid|heterochromatin organization|DNA conformation change|hormone secretion|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|astrocyte differentiation|transcription, DNA-templated|apoptotic process|negative regulation of double-strand break repair|regulation of transcription, DNA-templated|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|negative regulation of DNA binding|endodeoxyribonuclease activity|DNA packaging|negative regulation of glial cell differentiation|regulation of astrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|JAK-STAT cascade|negative regulation of nucleic acid-templated transcription|regulation of G2/M transition of mitotic cell cycle|mitotic G2/M transition checkpoint|negative regulation of G2/M transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|generation of neurons|regulation of gliogenesis|regulation of nucleic acid-templated transcription|regulation of JAK-STAT cascade|regulation of glial cell differentiation|negative regulation of cell cycle G2/M phase transition|transcription regulatory region DNA binding|negative regulation of double-strand break repair via nonhomologous end joining|heterochromatin assembly|negative regulation of JAK-STAT cascade|positive regulation of transcription regulatory region DNA binding|peptidyl-amino acid modification|gliogenesis|protein serine/threonine kinase activity|histone H2A-S139 phosphorylation|regulation of cell cycle G2/M phase transition|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|negative regulation by host of viral transcription|regulation of double-strand break repair via nonhomologous end joining|cellular response to X-ray|G2 DNA damage checkpoint|negative regulation of astrocyte differentiation|growth hormone secretion|senescence-associated heterochromatin focus assembly|cAMP response element binding|core promoter binding|peptidyl-serine phosphorylation|AT DNA binding|DNA-dependent protein kinase activity K09283 high mobility group AT-hook protein 2[-] hsa05206|hsa05202 MicroRNAs in cancer - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human) 12:65824131-65966295 590 621 717 2646 3367 1515 2.20003815007567 2.10450421801582 2.41052689433069 8.84027905087109 10.3012385386328 5.29443999713046 2.23835642080739 8.14531919554478 -1.86353145596884 2.98030924940754e-12 9.77737937712229e-11 DOWN ENSG00000087589 CASS4 Cas scaffolding protein family member 4 [Source:HGNC Symbol;Acc:HGNC:15878] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0004872|GO:0030055|GO:0050794|GO:0043229|GO:0005057|GO:0071704|GO:0044237|GO:0038023|GO:0007155|GO:0005622|GO:0005515|GO:0016740|GO:0005924|GO:0005912|GO:0016772|GO:0005737|GO:0007154|GO:0007165|GO:0000155|GO:0019538|GO:0023014|GO:0043412|GO:0036211|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0016773|GO:0005856|GO:0005925|GO:0016310|GO:0000160|GO:0004672|GO:0004673|GO:0006464|GO:0006468 signal transducer activity|signaling|cell|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|receptor activity|cell-substrate junction|regulation of cellular process|intracellular organelle|receptor signaling protein activity|organic substance metabolic process|cellular metabolic process|signaling receptor activity|cell adhesion|intracellular|protein binding|transferase activity|cell-substrate adherens junction|adherens junction|transferase activity, transferring phosphorus-containing groups|cytoplasm|cell communication|signal transduction|phosphorelay sensor kinase activity|protein metabolic process|signal transduction by protein phosphorylation|macromolecule modification|protein modification process|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|focal adhesion|phosphorylation|phosphorelay signal transduction system|protein kinase activity|protein histidine kinase activity|cellular protein modification process|protein phosphorylation - - - - 20:56412112-56460387 40 48 28 1 1 6 0.394847200645325 0.430615475829659 0.24919323298273 0.00884018887814848 0.00810259943962496 0.0555100459135795 0.358218636485905 0.0241509447437843 3.89068886508771 3.00256895403562e-12 9.83959314531057e-11 UP ENSG00000120162 MOB3B MOB kinase activator 3B [Source:HGNC Symbol;Acc:HGNC:23825] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872 binding|ion binding|protein binding|cation binding|metal ion binding - - - - 9:27325209-27529781 0 2 8 39 55 42 0 0.0176371199119532 0.0699896318208104 0.339061327071123 0.437871413548009 0.381941548644193 0.0292089172442545 0.386291429754442 -3.72520888585769 3.03346923903728e-12 9.92995511647138e-11 DOWN ENSG00000027001 MIPEP mitochondrial intermediate peptidase [Source:HGNC Symbol;Acc:HGNC:7104] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0006810|GO:0034641|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0045184|GO:0008104|GO:0051649|GO:0019538|GO:0006996|GO:0006518|GO:0046872|GO:0072594|GO:0007005|GO:0051604|GO:0015031|GO:0046907|GO:0006508|GO:0005759|GO:0005739|GO:0034613|GO:0043603|GO:0044267|GO:0010467|GO:0006626|GO:0008237|GO:0006627|GO:0033365|GO:0016485|GO:0006839|GO:0006605|GO:0072655|GO:0006886|GO:0004175|GO:0034982|GO:0004222|GO:0070585 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|transport|cellular nitrogen compound metabolic process|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|establishment of protein localization|protein localization|establishment of localization in cell|protein metabolic process|organelle organization|peptide metabolic process|metal ion binding|establishment of protein localization to organelle|mitochondrion organization|protein maturation|protein transport|intracellular transport|proteolysis|mitochondrial matrix|mitochondrion|cellular protein localization|cellular amide metabolic process|cellular protein metabolic process|gene expression|protein targeting to mitochondrion|metallopeptidase activity|protein processing involved in protein targeting to mitochondrion|protein localization to organelle|protein processing|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|intracellular protein transport|endopeptidase activity|mitochondrial protein processing|metalloendopeptidase activity|protein localization to mitochondrion - - - - 13:23730189-23889419 130 127 156 514 488 422 2.45351140580439 2.17836653914079 2.65451150428825 8.6917471265497 7.55673681373746 7.4642770509384 2.42879648307781 7.90425366374185 -1.70238763988353 3.3866263715972e-12 1.10738602078491e-10 DOWN ENSG00000150054 MPP7 membrane protein, palmitoylated 7 [Source:HGNC Symbol;Acc:HGNC:26542] GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0050794|GO:0044089|GO:0032947|GO:0023051|GO:0005911|GO:0016043|GO:0071944|GO:0005515|GO:0005886|GO:0043234|GO:0035591|GO:0051130|GO:0098797|GO:0005912|GO:0051128|GO:0022607|GO:0009966|GO:0046983|GO:0019904|GO:0010646|GO:0008104|GO:0007163|GO:0007154|GO:0007165|GO:0009967|GO:0031334|GO:0043254|GO:0043296|GO:0045216|GO:0046982|GO:0097025|GO:0034329|GO:0030010|GO:0006461|GO:1902414|GO:0005923|GO:0071896|GO:0007043|GO:0070830|GO:0043297 macromolecular complex|structural molecule activity|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|binding, bridging|cellular response to stimulus|regulation of cellular process|positive regulation of cellular component biogenesis|protein complex scaffold|regulation of signaling|cell-cell junction|cellular component organization|cell periphery|protein binding|plasma membrane|protein complex|signaling adaptor activity|positive regulation of cellular component organization|plasma membrane protein complex|adherens junction|regulation of cellular component organization|cellular component assembly|regulation of signal transduction|protein dimerization activity|protein domain specific binding|regulation of cell communication|protein localization|establishment or maintenance of cell polarity|cell communication|signal transduction|positive regulation of signal transduction|positive regulation of protein complex assembly|regulation of protein complex assembly|apical junction complex|cell-cell junction organization|protein heterodimerization activity|MPP7-DLG1-LIN7 complex|cell junction assembly|establishment of cell polarity|protein complex assembly|protein localization to cell junction|bicellular tight junction|protein localization to adherens junction|cell-cell junction assembly|bicellular tight junction assembly|apical junction assembly - - - - 10:28050993-28334486 13 7 13 69 77 108 0.0901361937659865 0.0441130699089744 0.0812665459498536 0.42865306159003 0.438046512397603 0.701801334890098 0.0718386032082715 0.522833636292577 -2.86352075486008 3.56265073965046e-12 1.16366931270815e-10 DOWN ENSG00000198000 NOL8 nucleolar protein 8 [Source:HGNC Symbol;Acc:HGNC:23387] GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0009058|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0030307|GO:0046483|GO:0051128|GO:0043231|GO:0005737|GO:0006139|GO:0000166|GO:0044249|GO:0022613|GO:0001558|GO:0005730|GO:0034645|GO:0003723|GO:0042254|GO:0031981|GO:0006259|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006364|GO:0006260|GO:0006396|GO:0034660|GO:0044822|GO:0016072 growth|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|biosynthetic process|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cell growth|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of cell growth|nucleolus|cellular macromolecule biosynthetic process|RNA binding|ribosome biogenesis|nuclear lumen|DNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|rRNA processing|DNA replication|RNA processing|ncRNA metabolic process|poly(A) RNA binding|rRNA metabolic process - - - - 9:92297358-92325636 3131 3422 2315 1099 1156 764 12.8975709974527 12.8110559026994 8.59785420114441 4.05620875263054 3.90706654179727 2.94949079758402 11.4354937004322 3.63758869733728 1.65246432045153 3.78929081086783e-12 1.23634412970107e-10 UP ENSG00000100311 PDGFB platelet-derived growth factor beta polypeptide [Source:HGNC Symbol;Acc:HGNC:8800] GO:0040011|GO:0032502|GO:0040007|GO:0000003|GO:0002376|GO:0007610|GO:0023052|GO:0042056|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0048520|GO:0044702|GO:0071704|GO:0050900|GO:0006955|GO:0009628|GO:0009986|GO:0044237|GO:0050795|GO:0003006|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0005615|GO:0030234|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0007507|GO:0008284|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:0044255|GO:0050817|GO:0001890|GO:0003014|GO:0006935|GO:0045087|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0019838|GO:0016323|GO:0006810|GO:0022402|GO:0051130|GO:1901360|GO:0001568|GO:0032835|GO:0007275|GO:0010632|GO:0048513|GO:0051302|GO:0005102|GO:0034641|GO:0008047|GO:0043062|GO:0032940|GO:0006952|GO:0043270|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0051098|GO:0030141|GO:0043231|GO:0048608|GO:0072111|GO:0010243|GO:0048144|GO:0005737|GO:0007267|GO:0009611|GO:0050920|GO:0005975|GO:0071559|GO:0006928|GO:0032403|GO:0072593|GO:0050819|GO:0001775|GO:0009966|GO:0046983|GO:0072006|GO:0048568|GO:0050673|GO:0009890|GO:0045787|GO:0042493|GO:0010646|GO:0006139|GO:0001892|GO:0043085|GO:0050776|GO:0050865|GO:0007154|GO:0044092|GO:0055085|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0005783|GO:0009725|GO:0010634|GO:0001666|GO:0008217|GO:0030595|GO:0050790|GO:0030030|GO:0031983|GO:0051781|GO:0051301|GO:0045833|GO:0048869|GO:2000145|GO:0009967|GO:0044249|GO:0003104|GO:0090184|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0050878|GO:0003013|GO:0005794|GO:0050921|GO:0006996|GO:0071774|GO:0000165|GO:0016192|GO:0050679|GO:1902533|GO:1901724|GO:0032268|GO:0000902|GO:0006109|GO:0031175|GO:0005976|GO:0010468|GO:0090132|GO:0030193|GO:0008654|GO:0034645|GO:0035787|GO:0048660|GO:0030168|GO:0046486|GO:0090068|GO:0072143|GO:0007166|GO:0051100|GO:0070851|GO:0033993|GO:1903047|GO:0003071|GO:0001944|GO:0043412|GO:0097205|GO:0061458|GO:0072358|GO:0061005|GO:0031410|GO:0001655|GO:0010629|GO:0010544|GO:0072210|GO:0002064|GO:0046982|GO:0072110|GO:0007596|GO:0051252|GO:0072126|GO:0005518|GO:0038001|GO:1901652|GO:0048659|GO:0000904|GO:0009790|GO:0071417|GO:0001656|GO:0010628|GO:0030334|GO:0034767|GO:0051055|GO:0001935|GO:0001667|GO:0016023|GO:0006887|GO:0048661|GO:0090218|GO:0051347|GO:0036211|GO:2000377|GO:0000278|GO:0071560|GO:0042060|GO:0072001|GO:0006811|GO:0045737|GO:0048145|GO:0030195|GO:0060326|GO:0007346|GO:0043434|GO:0072012|GO:0007599|GO:0044344|GO:0010564|GO:0051247|GO:0048146|GO:0070848|GO:0031988|GO:0034765|GO:0006259|GO:0050678|GO:0072141|GO:0002764|GO:0016176|GO:0043269|GO:0090193|GO:0061045|GO:0010543|GO:0002548|GO:0032270|GO:0014070|GO:0060429|GO:0051054|GO:0006796|GO:1901342|GO:0035556|GO:0060205|GO:1901137|GO:0033043|GO:0044267|GO:0051174|GO:0007067|GO:0010467|GO:0050918|GO:0032990|GO:0005788|GO:0008610|GO:0007399|GO:0019216|GO:0046903|GO:0072224|GO:0071310|GO:0097485|GO:0000139|GO:0010594|GO:0030198|GO:0046890|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0034774|GO:0048858|GO:0061448|GO:0030335|GO:1902531|GO:0016070|GO:0045931|GO:0051928|GO:0008083|GO:0072359|GO:0031091|GO:0008015|GO:0032870|GO:0010557|GO:0016051|GO:0042803|GO:0006644|GO:1900127|GO:0048545|GO:0097305|GO:0010595|GO:0003073|GO:0034220|GO:0048407|GO:0043393|GO:2000379|GO:0010638|GO:0048666|GO:0030182|GO:0007411|GO:0043536|GO:0003093|GO:0045893|GO:0072239|GO:1904031|GO:0071071|GO:0045055|GO:0009792|GO:0031401|GO:0006260|GO:0008543|GO:0072202|GO:0030855|GO:1901653|GO:0043408|GO:0045892|GO:0046474|GO:0000271|GO:0014068|GO:0043552|GO:0007088|GO:0032774|GO:0090280|GO:0043550|GO:0014909|GO:0071072|GO:0006812|GO:2001141|GO:0071363|GO:0043535|GO:0016310|GO:0043627|GO:0014910|GO:0002768|GO:0038179|GO:1902679|GO:0070371|GO:0071407|GO:0007179|GO:0061564|GO:0001936|GO:0048017|GO:2000278|GO:0007167|GO:0014911|GO:0070528|GO:0071375|GO:0043410|GO:0006275|GO:0032355|GO:0010631|GO:0006024|GO:0045840|GO:0071506|GO:0072144|GO:1903725|GO:0001938|GO:0032868|GO:2000573|GO:0030203|GO:0014066|GO:0045740|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:2000591|GO:0031093|GO:0048812|GO:0032091|GO:0003094|GO:0071897|GO:0000079|GO:0043549|GO:0006351|GO:0005161|GO:0006650|GO:0006355|GO:0090279|GO:0061041|GO:0033674|GO:0043551|GO:0048011|GO:0000186|GO:0035793|GO:0007265|GO:0045859|GO:1903507|GO:0048015|GO:0045860|GO:0043406|GO:0046488|GO:0007409|GO:0006468|GO:0048699|GO:0010512|GO:1903506|GO:0043405|GO:0006661|GO:0042325|GO:0070374|GO:0001932|GO:0072255|GO:0032869|GO:0018193|GO:0038093|GO:0043009|GO:0030001|GO:0072254|GO:0035789|GO:0001934|GO:0007178|GO:0051924|GO:0002576|GO:0070372|GO:0043542|GO:0030213|GO:0042327|GO:0007169|GO:0048010|GO:0050731|GO:0050730|GO:0030212|GO:0061097|GO:0048008|GO:0046777|GO:0038095|GO:0031952|GO:0071902|GO:0018105|GO:0014065|GO:0071900|GO:0001701|GO:0061098|GO:0031954|GO:0032147|GO:0008286|GO:0038127|GO:0018108|GO:0043534|GO:0032148|GO:0035791|GO:0007173|GO:0006816|GO:0070509 locomotion|developmental process|growth|reproduction|immune system process|behavior|signaling|chemoattractant activity|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|positive regulation of behavior|single organism reproductive process|organic substance metabolic process|leukocyte migration|immune response|response to abiotic stimulus|cell surface|cellular metabolic process|regulation of behavior|developmental process involved in reproduction|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|extracellular space|enzyme regulator activity|regulation of developmental process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|heart development|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular lipid metabolic process|coagulation|placenta development|renal system process|chemotaxis|innate immune response|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|growth factor binding|basolateral plasma membrane|transport|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|glomerulus development|multicellular organism development|regulation of epithelial cell migration|animal organ development|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|enzyme activator activity|extracellular structure organization|secretion by cell|defense response|positive regulation of ion transport|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|regulation of binding|secretory granule|intracellular membrane-bounded organelle|reproductive structure development|cell proliferation involved in kidney development|response to organonitrogen compound|fibroblast proliferation|cytoplasm|cell-cell signaling|response to wounding|regulation of chemotaxis|carbohydrate metabolic process|response to transforming growth factor beta|movement of cell or subcellular component|protein complex binding|reactive oxygen species metabolic process|negative regulation of coagulation|cell activation|regulation of signal transduction|protein dimerization activity|nephron development|embryonic organ development|epithelial cell proliferation|negative regulation of biosynthetic process|positive regulation of cell cycle|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|positive regulation of catalytic activity|regulation of immune response|regulation of cell activation|cell communication|negative regulation of molecular function|transmembrane transport|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|endoplasmic reticulum|response to hormone|positive regulation of epithelial cell migration|response to hypoxia|regulation of blood pressure|leukocyte chemotaxis|regulation of catalytic activity|cell projection organization|vesicle lumen|positive regulation of cell division|cell division|negative regulation of lipid metabolic process|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|positive regulation of glomerular filtration|positive regulation of kidney development|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|Golgi apparatus|positive regulation of chemotaxis|organelle organization|response to fibroblast growth factor|MAPK cascade|vesicle-mediated transport|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|positive regulation of cell proliferation involved in kidney development|regulation of cellular protein metabolic process|cell morphogenesis|regulation of carbohydrate metabolic process|neuron projection development|polysaccharide metabolic process|regulation of gene expression|epithelium migration|regulation of blood coagulation|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|cell migration involved in kidney development|regulation of smooth muscle cell proliferation|platelet activation|glycerolipid metabolic process|positive regulation of cell cycle process|mesangial cell development|cell surface receptor signaling pathway|negative regulation of binding|growth factor receptor binding|response to lipid|mitotic cell cycle process|renal system process involved in regulation of systemic arterial blood pressure|vasculature development|macromolecule modification|renal filtration|reproductive system development|cardiovascular system development|cell differentiation involved in kidney development|cytoplasmic vesicle|urogenital system development|negative regulation of gene expression|negative regulation of platelet activation|metanephric nephron development|epithelial cell development|protein heterodimerization activity|glomerular mesangial cell proliferation|blood coagulation|regulation of RNA metabolic process|positive regulation of glomerular mesangial cell proliferation|collagen binding|paracrine signaling|response to peptide|smooth muscle cell proliferation|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|metanephros development|positive regulation of gene expression|regulation of cell migration|positive regulation of ion transmembrane transport|negative regulation of lipid biosynthetic process|endothelial cell proliferation|ameboidal-type cell migration|cytoplasmic, membrane-bounded vesicle|exocytosis|positive regulation of smooth muscle cell proliferation|positive regulation of lipid kinase activity|positive regulation of transferase activity|protein modification process|regulation of reactive oxygen species metabolic process|mitotic cell cycle|cellular response to transforming growth factor beta stimulus|wound healing|renal system development|ion transport|positive regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of fibroblast proliferation|negative regulation of blood coagulation|cell chemotaxis|regulation of mitotic cell cycle|response to peptide hormone|glomerulus vasculature development|hemostasis|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|response to growth factor|membrane-bounded vesicle|regulation of ion transmembrane transport|DNA metabolic process|regulation of epithelial cell proliferation|renal interstitial fibroblast development|immune response-regulating signaling pathway|superoxide-generating NADPH oxidase activator activity|regulation of ion transport|positive regulation of glomerulus development|negative regulation of wound healing|regulation of platelet activation|monocyte chemotaxis|positive regulation of cellular protein metabolic process|response to organic cyclic compound|epithelium development|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|cytoplasmic membrane-bounded vesicle lumen|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|gene expression|positive chemotaxis|cell part morphogenesis|endoplasmic reticulum lumen|lipid biosynthetic process|nervous system development|regulation of lipid metabolic process|secretion|metanephric glomerulus development|cellular response to organic substance|neuron projection guidance|Golgi membrane|regulation of endothelial cell migration|extracellular matrix organization|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|secretory granule lumen|cell projection morphogenesis|connective tissue development|positive regulation of cell migration|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of mitotic cell cycle|positive regulation of calcium ion transport|growth factor activity|circulatory system development|platelet alpha granule|blood circulation|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|carbohydrate biosynthetic process|protein homodimerization activity|phospholipid metabolic process|positive regulation of hyaluronan biosynthetic process|response to steroid hormone|response to alcohol|positive regulation of endothelial cell migration|regulation of systemic arterial blood pressure|ion transmembrane transport|platelet-derived growth factor binding|regulation of protein binding|positive regulation of reactive oxygen species metabolic process|positive regulation of organelle organization|neuron development|neuron differentiation|axon guidance|positive regulation of blood vessel endothelial cell migration|regulation of glomerular filtration|positive regulation of transcription, DNA-templated|metanephric glomerulus vasculature development|positive regulation of cyclin-dependent protein kinase activity|regulation of phospholipid biosynthetic process|regulated exocytosis|embryo development ending in birth or egg hatching|positive regulation of protein modification process|DNA replication|fibroblast growth factor receptor signaling pathway|cell differentiation involved in metanephros development|epithelial cell differentiation|cellular response to peptide|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|glycerophospholipid biosynthetic process|polysaccharide biosynthetic process|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of phosphatidylinositol 3-kinase activity|regulation of mitotic nuclear division|RNA biosynthetic process|positive regulation of calcium ion import|regulation of lipid kinase activity|smooth muscle cell migration|negative regulation of phospholipid biosynthetic process|cation transport|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|regulation of blood vessel endothelial cell migration|phosphorylation|response to estrogen|regulation of smooth muscle cell migration|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|negative regulation of RNA biosynthetic process|ERK1 and ERK2 cascade|cellular response to organic cyclic compound|transforming growth factor beta receptor signaling pathway|axon development|regulation of endothelial cell proliferation|inositol lipid-mediated signaling|regulation of DNA biosynthetic process|enzyme linked receptor protein signaling pathway|positive regulation of smooth muscle cell migration|protein kinase C signaling|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of DNA replication|response to estradiol|epithelial cell migration|glycosaminoglycan biosynthetic process|positive regulation of mitotic nuclear division|cellular response to mycophenolic acid|glomerular mesangial cell development|regulation of phospholipid metabolic process|positive regulation of endothelial cell proliferation|response to insulin|positive regulation of DNA biosynthetic process|glycosaminoglycan metabolic process|regulation of phosphatidylinositol 3-kinase signaling|positive regulation of DNA replication|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|positive regulation of metanephric mesenchymal cell migration|platelet alpha granule lumen|neuron projection morphogenesis|negative regulation of protein binding|glomerular filtration|DNA biosynthetic process|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|transcription, DNA-templated|platelet-derived growth factor receptor binding|glycerophospholipid metabolic process|regulation of transcription, DNA-templated|regulation of calcium ion import|regulation of wound healing|positive regulation of kinase activity|regulation of phosphatidylinositol 3-kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|Ras protein signal transduction|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|phosphatidylinositol metabolic process|axonogenesis|protein phosphorylation|generation of neurons|negative regulation of phosphatidylinositol biosynthetic process|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|phosphatidylinositol biosynthetic process|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|metanephric glomerular mesangial cell development|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|chordate embryonic development|metal ion transport|metanephric glomerular mesangial cell differentiation|metanephric mesenchymal cell migration|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|regulation of calcium ion transport|platelet degranulation|regulation of ERK1 and ERK2 cascade|endothelial cell migration|hyaluronan biosynthetic process|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|hyaluronan metabolic process|regulation of protein tyrosine kinase activity|platelet-derived growth factor receptor signaling pathway|protein autophosphorylation|Fc-epsilon receptor signaling pathway|regulation of protein autophosphorylation|positive regulation of protein serine/threonine kinase activity|peptidyl-serine phosphorylation|phosphatidylinositol 3-kinase signaling|regulation of protein serine/threonine kinase activity|in utero embryonic development|positive regulation of protein tyrosine kinase activity|positive regulation of protein autophosphorylation|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|blood vessel endothelial cell migration|activation of protein kinase B activity|platelet-derived growth factor receptor-beta signaling pathway|epidermal growth factor receptor signaling pathway|calcium ion transport|calcium ion import K17386 platelet-derived growth factor subunit B[-] hsa05200|hsa04151|hsa04060|hsa05166|hsa05206|hsa04010|hsa04014|hsa04810|hsa04015|hsa04510|hsa04072|hsa05231|hsa05215|hsa04540|hsa05218|hsa05211|hsa05214 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Melanoma - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Glioma - Homo sapiens (human) 22:39223359-39244751 230 270 394 834 984 953 3.82360713243615 4.07933526706199 5.90549588793602 12.4225230938103 13.4217561671105 14.8480102791447 4.60281276247805 13.5640965133552 -1.55920529322911 3.7972330621878e-12 1.23758292400169e-10 DOWN ENSG00000164086 DUSP7 dual specificity phosphatase 7 [Source:HGNC Symbol;Acc:HGNC:3073] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0016787|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0019222|GO:0002757|GO:0006935|GO:0045087|GO:0048468|GO:0007275|GO:0016788|GO:0006952|GO:0031325|GO:0033554|GO:0043231|GO:0010243|GO:0005737|GO:0002218|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0009968|GO:0009725|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007166|GO:0043412|GO:0002758|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0032269|GO:0031981|GO:0031098|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0005654|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:1902532|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0005634|GO:0042578|GO:0045089|GO:0045088|GO:0048666|GO:0030182|GO:0007411|GO:0016311|GO:0031401|GO:0008543|GO:1901653|GO:0043408|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0002221|GO:0061564|GO:0007167|GO:0071375|GO:0043410|GO:0016791|GO:0043409|GO:0033673|GO:0032868|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0051403|GO:0043549|GO:0033674|GO:0048011|GO:0006470|GO:0000186|GO:0007265|GO:0045859|GO:0045860|GO:0002224|GO:0043406|GO:0006469|GO:0007409|GO:0006468|GO:0043407|GO:0048699|GO:0043405|GO:0042325|GO:0004721|GO:0001932|GO:0032869|GO:0042326|GO:0038093|GO:0001934|GO:0001933|GO:0042327|GO:0007169|GO:0048010|GO:0035335|GO:0034166|GO:0034134|GO:0038124|GO:0000187|GO:0038095|GO:0002756|GO:0071901|GO:0071902|GO:0000188|GO:0034138|GO:0002755|GO:0008138|GO:0034146|GO:0033549|GO:0071900|GO:0034142|GO:0038123|GO:0034162|GO:0004725|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0035666|GO:0017017 locomotion|developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|anatomical structure development|regulation of metabolic process|immune response-activating signal transduction|chemotaxis|innate immune response|cell development|multicellular organism development|hydrolase activity, acting on ester bonds|defense response|positive regulation of cellular metabolic process|cellular response to stress|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|activation of innate immune response|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|negative regulation of signal transduction|response to hormone|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|cell surface receptor signaling pathway|macromolecule modification|innate immune response-activating signal transduction|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|nuclear lumen|stress-activated protein kinase signaling cascade|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|nucleoplasm|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|nucleus|phosphoric ester hydrolase activity|positive regulation of innate immune response|regulation of innate immune response|neuron development|neuron differentiation|axon guidance|dephosphorylation|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular response to peptide|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|pattern recognition receptor signaling pathway|axon development|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|phosphatase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|response to insulin|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|stress-activated MAPK cascade|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|protein dephosphorylation|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|negative regulation of protein kinase activity|axonogenesis|protein phosphorylation|negative regulation of MAP kinase activity|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|cellular response to insulin stimulus|negative regulation of phosphorylation|Fc receptor signaling pathway|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|peptidyl-tyrosine dephosphorylation|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|activation of MAPK activity|Fc-epsilon receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|inactivation of MAPK activity|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|protein tyrosine/serine/threonine phosphatase activity|toll-like receptor 5 signaling pathway|MAP kinase phosphatase activity|regulation of protein serine/threonine kinase activity|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|protein tyrosine phosphatase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|TRIF-dependent toll-like receptor signaling pathway|MAP kinase tyrosine/serine/threonine phosphatase activity K04459 dual specificity MAP kinase phosphatase[3.1.3.48] hsa04010 MAPK signaling pathway - Homo sapiens (human) 3:52048919-52056550 693 749 565 240 267 196 7.66067278103069 7.52481333508308 5.63113479090701 2.37707324268541 2.42165929206044 2.03057164858446 6.93887363567359 2.27643472777677 1.6079254003627 3.82523834202223e-12 1.24535076840493e-10 UP ENSG00000158246 FAM46B family with sequence similarity 46 member B [Source:HGNC Symbol;Acc:HGNC:28273] GO:0005488|GO:0005515 binding|protein binding - - - - 1:27005020-27012836 164 137 210 31 45 51 4.8990010181969 3.71933733508885 5.6558518486238 0.829691830022723 1.10293113837252 1.42778552143836 4.75806340063652 1.12013616327787 2.08670037929187 3.86068860743049e-12 1.25552285061253e-10 UP ENSG00000120802 TMPO thymopoietin [Source:HGNC Symbol;Acc:HGNC:11875] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0000785|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:0019866|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005521|GO:0005737|GO:0005635|GO:0006139|GO:0005783|GO:0031965|GO:0016021|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0005637|GO:0005694|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|chromatin|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organelle inner membrane|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|lamin binding|cytoplasm|nuclear envelope|nucleobase-containing compound metabolic process|endoplasmic reticulum|nuclear membrane|integral component of membrane|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|nuclear inner membrane|chromosome|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 12:98515512-98550379 806 982 942 2396 3246 2436 3.6337732424587 4.02359410394914 3.8290242045104 9.67848268891092 12.0071298183749 10.2926950009074 3.82879718363941 10.6594358360644 -1.47716793778907 3.92614384505368e-12 1.27542000381102e-10 DOWN ENSG00000074054 CLASP1 cytoplasmic linker associated protein 1 [Source:HGNC Symbol;Acc:HGNC:17088] GO:0040011|GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0040013|GO:0045178|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0006950|GO:0044089|GO:0051641|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0060341|GO:0051272|GO:0007049|GO:0006935|GO:0045595|GO:0051640|GO:0009888|GO:0048468|GO:0006810|GO:0022402|GO:0051130|GO:0005938|GO:0007275|GO:1903690|GO:0010632|GO:0060627|GO:0048513|GO:0005924|GO:0043062|GO:0005874|GO:0000776|GO:0032940|GO:0030155|GO:0005912|GO:0031982|GO:0051128|GO:2000147|GO:0022607|GO:0043231|GO:1901201|GO:0005737|GO:0032970|GO:0009611|GO:0032886|GO:0006903|GO:0006928|GO:0032403|GO:0051656|GO:1901888|GO:1901203|GO:0031589|GO:0048729|GO:0048598|GO:0032231|GO:0010171|GO:0007163|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0070062|GO:0051649|GO:0008092|GO:0051271|GO:0010634|GO:0051047|GO:0030030|GO:0001948|GO:0051301|GO:0048869|GO:0030029|GO:2000145|GO:0007017|GO:0031334|GO:0043254|GO:0040019|GO:2000146|GO:0010256|GO:0005794|GO:0006996|GO:0045180|GO:0051017|GO:0016192|GO:0031023|GO:0051650|GO:0015631|GO:0000902|GO:0005829|GO:0051653|GO:0031175|GO:1990752|GO:0005813|GO:0010172|GO:0090132|GO:0045216|GO:0032956|GO:2000736|GO:0002009|GO:1903047|GO:0022617|GO:0007010|GO:0007030|GO:0070507|GO:1903053|GO:0005815|GO:0010717|GO:0044770|GO:0000904|GO:0045921|GO:0009790|GO:0008017|GO:0030334|GO:0044319|GO:0001667|GO:0006887|GO:0032232|GO:0000278|GO:0007369|GO:0007160|GO:0042060|GO:1904261|GO:0034329|GO:0017157|GO:0051046|GO:0060485|GO:0030010|GO:0043242|GO:0030981|GO:0010810|GO:0043515|GO:0022604|GO:0005876|GO:0007051|GO:0085029|GO:0005694|GO:0006461|GO:0043244|GO:0030036|GO:0030336|GO:0051293|GO:0061045|GO:0070925|GO:0035371|GO:0060429|GO:0035556|GO:0032273|GO:0033043|GO:0007067|GO:0048864|GO:0032990|GO:0007399|GO:0046903|GO:0097485|GO:0030198|GO:0051648|GO:0002162|GO:0010470|GO:0030154|GO:0005881|GO:0048858|GO:0030335|GO:0000226|GO:0005856|GO:0051492|GO:0005819|GO:0000777|GO:0005925|GO:0045995|GO:1903689|GO:0010638|GO:0048666|GO:0030182|GO:0034453|GO:0007411|GO:0043241|GO:0051225|GO:0010715|GO:0048863|GO:0034622|GO:0051010|GO:0010769|GO:0034332|GO:0002011|GO:0031113|GO:0000086|GO:0051294|GO:0031122|GO:0070831|GO:0000793|GO:0044772|GO:0051497|GO:0014031|GO:0043623|GO:0031116|GO:0071711|GO:0061564|GO:0007052|GO:0031110|GO:0051494|GO:0051493|GO:0090091|GO:0001952|GO:0007044|GO:0015630|GO:0007020|GO:0031109|GO:0040001|GO:0001578|GO:0010631|GO:0048041|GO:1901879|GO:0005828|GO:0048762|GO:0031032|GO:0022008|GO:0030038|GO:0048667|GO:0007264|GO:0051893|GO:0030863|GO:0090162|GO:0007015|GO:0031592|GO:0051495|GO:0048812|GO:0090307|GO:0001837|GO:0010458|GO:0030953|GO:0034333|GO:0061041|GO:0000775|GO:0035313|GO:0007019|GO:0051258|GO:0000779|GO:0007409|GO:0007026|GO:0048699|GO:0043624|GO:0031111|GO:0043149|GO:0046785|GO:0061572|GO:0051261 locomotion|developmental process|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|basal part of cell|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|response to stress|positive regulation of cellular component biogenesis|cellular localization|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of cellular localization|positive regulation of cellular component movement|cell cycle|chemotaxis|regulation of cell differentiation|organelle localization|tissue development|cell development|transport|cell cycle process|positive regulation of cellular component organization|cell cortex|multicellular organism development|negative regulation of wound healing, spreading of epidermal cells|regulation of epithelial cell migration|regulation of vesicle-mediated transport|animal organ development|cell-substrate adherens junction|extracellular structure organization|microtubule|kinetochore|secretion by cell|regulation of cell adhesion|adherens junction|vesicle|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|intracellular membrane-bounded organelle|regulation of extracellular matrix assembly|cytoplasm|regulation of actin filament-based process|response to wounding|regulation of microtubule-based process|vesicle targeting|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|regulation of cell junction assembly|positive regulation of extracellular matrix assembly|cell-substrate adhesion|tissue morphogenesis|embryonic morphogenesis|regulation of actin filament bundle assembly|body morphogenesis|establishment or maintenance of cell polarity|cell communication|regulation of cellular component movement|cell migration|signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|negative regulation of cellular component movement|positive regulation of epithelial cell migration|positive regulation of secretion|cell projection organization|glycoprotein binding|cell division|cellular developmental process|actin filament-based process|regulation of cell motility|microtubule-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|positive regulation of embryonic development|negative regulation of cell motility|endomembrane system organization|Golgi apparatus|organelle organization|basal cortex|actin filament bundle assembly|vesicle-mediated transport|microtubule organizing center organization|establishment of vesicle localization|tubulin binding|cell morphogenesis|cytosol|spindle localization|neuron projection development|microtubule end|centrosome|embryonic body morphogenesis|epithelium migration|cell-cell junction organization|regulation of actin cytoskeleton organization|regulation of stem cell differentiation|morphogenesis of an epithelium|mitotic cell cycle process|extracellular matrix disassembly|cytoskeleton organization|Golgi organization|regulation of microtubule cytoskeleton organization|regulation of extracellular matrix organization|microtubule organizing center|regulation of epithelial to mesenchymal transition|cell cycle phase transition|cell morphogenesis involved in differentiation|positive regulation of exocytosis|embryo development|microtubule binding|regulation of cell migration|wound healing, spreading of cells|ameboidal-type cell migration|exocytosis|negative regulation of actin filament bundle assembly|mitotic cell cycle|gastrulation|cell-matrix adhesion|wound healing|positive regulation of basement membrane assembly involved in embryonic body morphogenesis|cell junction assembly|regulation of exocytosis|regulation of secretion|mesenchyme development|establishment of cell polarity|negative regulation of protein complex disassembly|cortical microtubule cytoskeleton|regulation of cell-substrate adhesion|kinetochore binding|regulation of cell morphogenesis|spindle microtubule|spindle organization|extracellular matrix assembly|chromosome|protein complex assembly|regulation of protein complex disassembly|actin cytoskeleton organization|negative regulation of cell migration|establishment of spindle localization|negative regulation of wound healing|organelle assembly|microtubule plus-end|epithelium development|intracellular signal transduction|positive regulation of protein polymerization|regulation of organelle organization|mitotic nuclear division|stem cell development|cell part morphogenesis|nervous system development|secretion|neuron projection guidance|extracellular matrix organization|vesicle localization|dystroglycan binding|regulation of gastrulation|cell differentiation|cytoplasmic microtubule|cell projection morphogenesis|positive regulation of cell migration|microtubule cytoskeleton organization|cytoskeleton|regulation of stress fiber assembly|spindle|condensed chromosome kinetochore|focal adhesion|regulation of embryonic development|regulation of wound healing, spreading of epidermal cells|positive regulation of organelle organization|neuron development|neuron differentiation|microtubule anchoring|axon guidance|protein complex disassembly|spindle assembly|regulation of extracellular matrix disassembly|stem cell differentiation|cellular macromolecular complex assembly|microtubule plus-end binding|regulation of cell morphogenesis involved in differentiation|adherens junction organization|morphogenesis of an epithelial sheet|regulation of microtubule polymerization|G2/M transition of mitotic cell cycle|establishment of spindle orientation|cytoplasmic microtubule organization|basement membrane assembly|condensed chromosome|mitotic cell cycle phase transition|negative regulation of stress fiber assembly|mesenchymal cell development|cellular protein complex assembly|positive regulation of microtubule polymerization|basement membrane organization|axon development|mitotic spindle organization|regulation of microtubule polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|positive regulation of extracellular matrix disassembly|regulation of cell-matrix adhesion|cell-substrate junction assembly|microtubule cytoskeleton|microtubule nucleation|microtubule polymerization or depolymerization|establishment of mitotic spindle localization|microtubule bundle formation|epithelial cell migration|focal adhesion assembly|regulation of protein depolymerization|kinetochore microtubule|mesenchymal cell differentiation|actomyosin structure organization|neurogenesis|contractile actin filament bundle assembly|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|regulation of focal adhesion assembly|cortical cytoskeleton|establishment of epithelial cell polarity|actin filament organization|centrosomal corona|positive regulation of cytoskeleton organization|neuron projection morphogenesis|mitotic spindle assembly|epithelial to mesenchymal transition|exit from mitosis|astral microtubule organization|adherens junction assembly|regulation of wound healing|chromosome, centromeric region|wound healing, spreading of epidermal cells|microtubule depolymerization|protein polymerization|condensed chromosome, centromeric region|axonogenesis|negative regulation of microtubule depolymerization|generation of neurons|cellular protein complex disassembly|negative regulation of microtubule polymerization or depolymerization|stress fiber assembly|microtubule polymerization|actin filament bundle organization|protein depolymerization - - - - 2:121337776-121649587 554 593 715 1713 1979 1622 2.80236335668282 2.72614420463001 3.26087951097395 7.76370950502826 8.21349755998236 7.68942703818546 2.92979569076226 7.88887803439869 -1.42902007117772 3.94211125005504e-12 1.27921510064286e-10 DOWN ENSG00000113269 RNF130 ring finger protein 130 [Source:HGNC Symbol;Acc:HGNC:18280] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0031224|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0043231|GO:0043169|GO:0005737|GO:0008219|GO:0019787|GO:0016021|GO:0019538|GO:0046872|GO:0043412|GO:0004842|GO:0036211|GO:0012501|GO:0044267|GO:0005634|GO:0046914|GO:0006464|GO:0006915|GO:0008270|GO:0032446|GO:0016567 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|ligase activity|intracellular|protein binding|transferase activity|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell death|ubiquitin-like protein transferase activity|integral component of membrane|protein metabolic process|metal ion binding|macromolecule modification|ubiquitin-protein transferase activity|protein modification process|programmed cell death|cellular protein metabolic process|nucleus|transition metal ion binding|cellular protein modification process|apoptotic process|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 5:179911651-180072118 201 217 342 760 849 829 0.919252319880759 0.901944460840237 1.41019976699076 3.114233207855 3.18577667326603 3.5532290398699 1.07713218257059 3.28441297366364 -1.60844023515371 3.97029402727072e-12 1.28696154060956e-10 DOWN ENSG00000102466 FGF14 fibroblast growth factor 14 [Source:HGNC Symbol;Acc:HGNC:3671] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0006914|GO:0023051|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0060341|GO:0008201|GO:0050804|GO:0042391|GO:0051640|GO:0006810|GO:0007275|GO:0050688|GO:0060627|GO:0005102|GO:0043168|GO:0006952|GO:0043270|GO:0033554|GO:0098542|GO:0050803|GO:0043231|GO:0007267|GO:0051656|GO:0009615|GO:0010646|GO:0007154|GO:0055085|GO:0007165|GO:0051649|GO:0016236|GO:0051607|GO:0019538|GO:0023014|GO:0005539|GO:0032411|GO:0000165|GO:0016192|GO:0051650|GO:0048167|GO:0098792|GO:0043412|GO:0032386|GO:0060078|GO:0048489|GO:0034767|GO:0036211|GO:0046907|GO:0006811|GO:1902803|GO:0031098|GO:0034765|GO:0043269|GO:0006796|GO:0035556|GO:0044267|GO:0007399|GO:0032414|GO:0051648|GO:0051928|GO:0008083|GO:0005634|GO:0022898|GO:0050691|GO:0034220|GO:0098655|GO:0006812|GO:1901021|GO:0016310|GO:0016482|GO:0032412|GO:0002230|GO:0036465|GO:2001259|GO:1903421|GO:1904427|GO:0006464|GO:0051403|GO:1903169|GO:0006468|GO:0007254|GO:1901019|GO:1901387|GO:0030001|GO:0051924|GO:2001257|GO:0007268|GO:1901385|GO:0070588|GO:1901843|GO:1901841|GO:0006816 developmental process|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|autophagy|regulation of signaling|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|regulation of immune system process|protein binding|anatomical structure development|regulation of cellular localization|heparin binding|modulation of synaptic transmission|regulation of membrane potential|organelle localization|transport|multicellular organism development|regulation of defense response to virus|regulation of vesicle-mediated transport|receptor binding|anion binding|defense response|positive regulation of ion transport|cellular response to stress|defense response to other organism|regulation of synapse structure or activity|intracellular membrane-bounded organelle|cell-cell signaling|establishment of organelle localization|response to virus|regulation of cell communication|cell communication|transmembrane transport|signal transduction|establishment of localization in cell|macroautophagy|defense response to virus|protein metabolic process|signal transduction by protein phosphorylation|glycosaminoglycan binding|positive regulation of transporter activity|MAPK cascade|vesicle-mediated transport|establishment of vesicle localization|regulation of synaptic plasticity|xenophagy|macromolecule modification|regulation of intracellular transport|regulation of postsynaptic membrane potential|synaptic vesicle transport|positive regulation of ion transmembrane transport|protein modification process|intracellular transport|ion transport|regulation of synaptic vesicle transport|stress-activated protein kinase signaling cascade|regulation of ion transmembrane transport|regulation of ion transport|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|nervous system development|positive regulation of ion transmembrane transporter activity|vesicle localization|positive regulation of calcium ion transport|growth factor activity|nucleus|regulation of transmembrane transporter activity|regulation of defense response to virus by host|ion transmembrane transport|cation transmembrane transport|cation transport|positive regulation of calcium ion transmembrane transporter activity|phosphorylation|cytosolic transport|regulation of ion transmembrane transporter activity|positive regulation of defense response to virus by host|synaptic vesicle recycling|positive regulation of cation channel activity|regulation of synaptic vesicle recycling|positive regulation of calcium ion transmembrane transport|cellular protein modification process|stress-activated MAPK cascade|regulation of calcium ion transmembrane transport|protein phosphorylation|JNK cascade|regulation of calcium ion transmembrane transporter activity|positive regulation of voltage-gated calcium channel activity|metal ion transport|regulation of calcium ion transport|regulation of cation channel activity|synaptic transmission|regulation of voltage-gated calcium channel activity|calcium ion transmembrane transport|positive regulation of high voltage-gated calcium channel activity|regulation of high voltage-gated calcium channel activity|calcium ion transport K04358 fibroblast growth factor[-] hsa05200|hsa04151|hsa04010|hsa04014|hsa04810|hsa04015|hsa05218 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Melanoma - Homo sapiens (human) 13:101710804-102402457 29 29 44 143 191 143 0.144087428314963 0.130951898921886 0.197103851900095 0.636592919212134 0.778626853831481 0.665874859434608 0.157381059712315 0.693698210826074 -2.14004623587693 3.98522737418506e-12 1.2904010632204e-10 DOWN ENSG00000070087 PFN2 profilin 2 [Source:HGNC Symbol;Acc:HGNC:8882] GO:0040011|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0036094|GO:1903561|GO:0040013|GO:0042995|GO:0097159|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0044089|GO:0016079|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0016043|GO:0043227|GO:0008289|GO:0009893|GO:0031224|GO:0030234|GO:0005622|GO:0007269|GO:0005515|GO:0019222|GO:0060341|GO:0050804|GO:0051640|GO:0006810|GO:0051130|GO:0043195|GO:0010632|GO:0060627|GO:0032535|GO:0043168|GO:0032940|GO:0005543|GO:0031982|GO:0031325|GO:0051128|GO:0022607|GO:0005737|GO:0032970|GO:0007267|GO:0006928|GO:0051656|GO:0043005|GO:0032231|GO:0010646|GO:0043085|GO:0007154|GO:0051270|GO:0060491|GO:0016477|GO:0032233|GO:0070062|GO:0031647|GO:0051649|GO:0008092|GO:0044306|GO:0051271|GO:0001505|GO:2000300|GO:0050790|GO:0000166|GO:0030030|GO:0016021|GO:0030029|GO:2000145|GO:0010633|GO:0019538|GO:0031334|GO:0043254|GO:0031323|GO:2000146|GO:0006996|GO:0046928|GO:0051017|GO:0016192|GO:0006836|GO:0051650|GO:0032268|GO:0031333|GO:0031344|GO:1900027|GO:0090132|GO:0032956|GO:0030424|GO:0043412|GO:0007010|GO:0051345|GO:0050821|GO:0035091|GO:0032386|GO:0003779|GO:0048489|GO:0030334|GO:0001667|GO:0006887|GO:0036211|GO:0046907|GO:0031345|GO:0043679|GO:0017157|GO:1902803|GO:0051046|GO:0030031|GO:0051247|GO:0006461|GO:0030036|GO:0030336|GO:0032270|GO:0006796|GO:0032273|GO:0033043|GO:0044267|GO:0051174|GO:0046903|GO:0017076|GO:0051648|GO:0051246|GO:0031529|GO:0030832|GO:0051496|GO:0060590|GO:0005856|GO:0051492|GO:0010638|GO:0032781|GO:0045055|GO:0031401|GO:0003785|GO:0034622|GO:0030838|GO:0043623|GO:1900028|GO:0030554|GO:0016310|GO:0008064|GO:0016482|GO:0051494|GO:0051493|GO:0032272|GO:1901981|GO:1903305|GO:0010631|GO:0097178|GO:0000774|GO:0031032|GO:0030038|GO:0006464|GO:0007015|GO:0051495|GO:0030833|GO:0043462|GO:0051258|GO:0006468|GO:1902936|GO:0017156|GO:0042325|GO:0001932|GO:0018193|GO:0017158|GO:0030837|GO:0043149|GO:0001934|GO:0061572|GO:0042327|GO:0007268|GO:0008154|GO:0033138|GO:0018105|GO:0033135|GO:0030041|GO:0005546 locomotion|synapse|signaling|cell|membrane|cellular process|extracellular region|metabolic process|binding|small molecule binding|extracellular vesicle|negative regulation of locomotion|cell projection|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of cellular component biogenesis|synaptic vesicle exocytosis|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cellular component organization|membrane-bounded organelle|lipid binding|positive regulation of metabolic process|intrinsic component of membrane|enzyme regulator activity|intracellular|neurotransmitter secretion|protein binding|regulation of metabolic process|regulation of cellular localization|modulation of synaptic transmission|organelle localization|transport|positive regulation of cellular component organization|terminal bouton|regulation of epithelial cell migration|regulation of vesicle-mediated transport|regulation of cellular component size|anion binding|secretion by cell|phospholipid binding|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|cytoplasm|regulation of actin filament-based process|cell-cell signaling|movement of cell or subcellular component|establishment of organelle localization|neuron projection|regulation of actin filament bundle assembly|regulation of cell communication|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|regulation of cell projection assembly|cell migration|positive regulation of actin filament bundle assembly|extracellular exosome|regulation of protein stability|establishment of localization in cell|cytoskeletal protein binding|neuron projection terminus|negative regulation of cellular component movement|regulation of neurotransmitter levels|regulation of synaptic vesicle exocytosis|regulation of catalytic activity|nucleotide binding|cell projection organization|integral component of membrane|actin filament-based process|regulation of cell motility|negative regulation of epithelial cell migration|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|regulation of cellular metabolic process|negative regulation of cell motility|organelle organization|regulation of neurotransmitter secretion|actin filament bundle assembly|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|regulation of cellular protein metabolic process|negative regulation of protein complex assembly|regulation of cell projection organization|regulation of ruffle assembly|epithelium migration|regulation of actin cytoskeleton organization|axon|macromolecule modification|cytoskeleton organization|positive regulation of hydrolase activity|protein stabilization|phosphatidylinositol binding|regulation of intracellular transport|actin binding|synaptic vesicle transport|regulation of cell migration|ameboidal-type cell migration|exocytosis|protein modification process|intracellular transport|negative regulation of cell projection organization|axon terminus|regulation of exocytosis|regulation of synaptic vesicle transport|regulation of secretion|cell projection assembly|positive regulation of protein metabolic process|protein complex assembly|actin cytoskeleton organization|negative regulation of cell migration|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|positive regulation of protein polymerization|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|secretion|purine nucleotide binding|vesicle localization|regulation of protein metabolic process|ruffle organization|regulation of actin filament length|positive regulation of stress fiber assembly|ATPase regulator activity|cytoskeleton|regulation of stress fiber assembly|positive regulation of organelle organization|positive regulation of ATPase activity|regulated exocytosis|positive regulation of protein modification process|actin monomer binding|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|cellular protein complex assembly|negative regulation of ruffle assembly|adenyl nucleotide binding|phosphorylation|regulation of actin polymerization or depolymerization|cytosolic transport|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|phosphatidylinositol phosphate binding|regulation of regulated secretory pathway|epithelial cell migration|ruffle assembly|adenyl-nucleotide exchange factor activity|actomyosin structure organization|contractile actin filament bundle assembly|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|regulation of ATPase activity|protein polymerization|protein phosphorylation|phosphatidylinositol bisphosphate binding|calcium ion regulated exocytosis|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|regulation of calcium ion-dependent exocytosis|negative regulation of actin filament polymerization|stress fiber assembly|positive regulation of protein phosphorylation|actin filament bundle organization|positive regulation of phosphorylation|synaptic transmission|actin polymerization or depolymerization|positive regulation of peptidyl-serine phosphorylation|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|actin filament polymerization|phosphatidylinositol-4,5-bisphosphate binding K05759 profilin[-] hsa04810|hsa04015|hsa05132|hsa05131 Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Shigellosis - Homo sapiens (human) 3:149964904-150050788 291 332 664 2384 2850 1234 1.49694041172824 1.55213324778206 3.07959846935917 10.9879199531629 12.028853718098 5.94916044227058 2.04289070962316 9.65531137117716 -2.24071075998563 4.05940784324077e-12 1.31299633534247e-10 DOWN ENSG00000048471 SNX29 sorting nexin 29 [Source:HGNC Symbol;Acc:HGNC:30542] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0043167|GO:0043227|GO:0008289|GO:0016787|GO:0005622|GO:0043234|GO:0043168|GO:0005543|GO:0031982|GO:0016817|GO:0006928|GO:0005875|GO:0070062|GO:0007017|GO:0005871|GO:0035091|GO:0016818|GO:0007018|GO:0005856|GO:0015630|GO:0016462|GO:0017111|GO:0003774|GO:0003777 macromolecular complex|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|ion binding|membrane-bounded organelle|lipid binding|hydrolase activity|intracellular|protein complex|anion binding|phospholipid binding|vesicle|hydrolase activity, acting on acid anhydrides|movement of cell or subcellular component|microtubule associated complex|extracellular exosome|microtubule-based process|kinesin complex|phosphatidylinositol binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|microtubule-based movement|cytoskeleton|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|motor activity|microtubule motor activity - - - - 16:11976737-12574289 73 77 200 549 602 600 0.423921025247286 0.406383111792646 1.04714528015549 2.85648977048103 2.86831552869695 3.26545061291432 0.625816472398474 2.99675197069743 -2.25958814461271 4.13399859128289e-12 1.33567525913592e-10 DOWN ENSG00000169692 AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:325] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0044255|GO:0009888|GO:0060760|GO:0044281|GO:0019637|GO:0001817|GO:0043231|GO:0016746|GO:0005737|GO:0001816|GO:0009966|GO:0001819|GO:0042493|GO:0010646|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0016021|GO:0009967|GO:0044249|GO:0010033|GO:0008654|GO:0046486|GO:0007166|GO:0001959|GO:0034097|GO:0001961|GO:0006638|GO:0036276|GO:0016747|GO:0060429|GO:0006796|GO:0008610|GO:0071310|GO:0006644|GO:0019221|GO:0071617|GO:0046474|GO:0008544|GO:0071345|GO:0006639|GO:0006650|GO:0008374|GO:0006654|GO:0016024|GO:0046473|GO:0046341|GO:0006641|GO:0042171|GO:0019432|GO:0003841 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|anatomical structure development|organelle membrane|cellular lipid metabolic process|tissue development|positive regulation of response to cytokine stimulus|small molecule metabolic process|organophosphate metabolic process|regulation of cytokine production|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|cytokine production|regulation of signal transduction|positive regulation of cytokine production|response to drug|regulation of cell communication|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|phospholipid biosynthetic process|glycerolipid metabolic process|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|response to cytokine|positive regulation of cytokine-mediated signaling pathway|neutral lipid metabolic process|response to antidepressant|transferase activity, transferring acyl groups other than amino-acyl groups|epithelium development|phosphate-containing compound metabolic process|lipid biosynthetic process|cellular response to organic substance|phospholipid metabolic process|cytokine-mediated signaling pathway|lysophospholipid acyltransferase activity|glycerophospholipid biosynthetic process|epidermis development|cellular response to cytokine stimulus|acylglycerol metabolic process|glycerophospholipid metabolic process|O-acyltransferase activity|phosphatidic acid biosynthetic process|CDP-diacylglycerol biosynthetic process|phosphatidic acid metabolic process|CDP-diacylglycerol metabolic process|triglyceride metabolic process|lysophosphatidic acid acyltransferase activity|triglyceride biosynthetic process|1-acylglycerol-3-phosphate O-acyltransferase activity K13509 lysophosphatidate acyltransferase[2.3.1.51] hsa01100|hsa04072|hsa00564|hsa00561|hsa04975 Metabolic pathways - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human)|Fat digestion and absorption - Homo sapiens (human) 9:136673143-136687423 367 379 677 1418 1679 1560 6.53586189061712 6.13416865876767 10.8702517255635 22.6261418531031 24.5332525824522 26.0369430693137 7.8467607583161 24.3987791682897 -1.63663984272885 4.23202264892427e-12 1.36586815309173e-10 DOWN ENSG00000067829 IDH3G isocitrate dehydrogenase 3 (NAD+) gamma [Source:HGNC Symbol;Acc:HGNC:5386] GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0045926|GO:0043227|GO:0048037|GO:0040008|GO:0005622|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0015980|GO:0044281|GO:0001882|GO:0019637|GO:0046483|GO:0016614|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0051186|GO:0006139|GO:0055086|GO:0006099|GO:0050662|GO:0000166|GO:0006091|GO:0055114|GO:0005730|GO:0046872|GO:0035639|GO:0001883|GO:0032549|GO:0016616|GO:0031981|GO:0005654|GO:0005759|GO:0005739|GO:0006796|GO:0017076|GO:0045333|GO:0005634|GO:0051287|GO:0004448|GO:0009060|GO:0009117|GO:0000287|GO:0005524|GO:0030554|GO:0019752|GO:0072350|GO:0043648|GO:0004449|GO:0019674|GO:0006103|GO:0006101|GO:0006102|GO:0006734 growth|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|negative regulation of growth|membrane-bounded organelle|cofactor binding|regulation of growth|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|nucleoside binding|organophosphate metabolic process|heterocycle metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|tricarboxylic acid cycle|coenzyme binding|nucleotide binding|generation of precursor metabolites and energy|oxidation-reduction process|nucleolus|metal ion binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|nuclear lumen|nucleoplasm|mitochondrial matrix|mitochondrion|phosphate-containing compound metabolic process|purine nucleotide binding|cellular respiration|nucleus|NAD binding|isocitrate dehydrogenase activity|aerobic respiration|nucleotide metabolic process|magnesium ion binding|ATP binding|adenyl nucleotide binding|carboxylic acid metabolic process|tricarboxylic acid metabolic process|dicarboxylic acid metabolic process|isocitrate dehydrogenase (NAD+) activity|NAD metabolic process|2-oxoglutarate metabolic process|citrate metabolic process|isocitrate metabolic process|NADH metabolic process K00030 isocitrate dehydrogenase (NAD+)[1.1.1.41] hsa01100|hsa01200|hsa01230 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human) X:153785766-153794523 228 258 430 988 1064 916 2.66798696817527 2.74377567186103 4.53661342046248 10.3586710462457 10.2154832838032 10.0455514598897 3.31612535349959 10.2065685966462 -1.62192747144573 4.24849561570046e-12 1.36970397528209e-10 DOWN ENSG00000255284 AP006621.5 - - - - - - - 11:777578-784297 6 6 4 50 50 47 0.254742723702875 0.231526898243948 0.153128576222601 1.90210948014264 1.74182635626716 1.87025998394668 0.213132732723141 1.83806527345216 -3.10836391759785 4.55860950958742e-12 1.46809847140478e-10 DOWN ENSG00000187987 ZSCAN23 zinc finger and SCAN domain containing 23 [Source:HGNC Symbol;Acc:HGNC:21193] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0001071|GO:0005488|GO:1903561|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0070062|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|extracellular region|metabolic process|nucleic acid binding transcription factor activity|binding|extracellular vesicle|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|extracellular exosome|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 6:28431930-28443502 1 3 14 56 84 110 0.0166549054889654 0.0453971124723649 0.21014185171899 0.835302308674665 1.14738026559755 1.716250578796 0.0907312898934401 1.23297771768941 -3.76440274828091 4.67120980541436e-12 1.50274027511681e-10 DOWN ENSG00000171861 RNMTL1 RNA methyltransferase like 1 [Source:HGNC Symbol;Acc:HGNC:18485] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0022613|GO:0008168|GO:0003723|GO:0043412|GO:0042254|GO:0001510|GO:0005739|GO:0010467|GO:0016070|GO:0006364|GO:0006396|GO:0034660|GO:0009451|GO:0044822|GO:0008173|GO:0016072 cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|methyltransferase activity|RNA binding|macromolecule modification|ribosome biogenesis|RNA methylation|mitochondrion|gene expression|RNA metabolic process|rRNA processing|RNA processing|ncRNA metabolic process|RNA modification|poly(A) RNA binding|RNA methyltransferase activity|rRNA metabolic process - - - - 17:782273-792509 1198 1203 752 355 372 243 24.4567728161289 22.3196870635193 13.8412198795981 6.49335218354626 6.23094408240975 4.64920089828201 20.2058932530821 5.79116572141267 1.80285044390291 4.68704531991196e-12 1.50621152831702e-10 UP ENSG00000156510 HKDC1 hexokinase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23302] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0030246|GO:0005622|GO:0016740|GO:0044262|GO:0048029|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0005737|GO:0005975|GO:0042592|GO:0019725|GO:0051186|GO:0006139|GO:0055086|GO:0000166|GO:0006091|GO:0005829|GO:0035639|GO:0005536|GO:0019693|GO:0048878|GO:0001883|GO:0009116|GO:0032549|GO:0055082|GO:0005996|GO:0016052|GO:0016301|GO:0051156|GO:0006796|GO:0017076|GO:0046835|GO:0016773|GO:0006757|GO:0019318|GO:0001678|GO:0009259|GO:0009117|GO:0019200|GO:0005524|GO:0030554|GO:0016310|GO:0009132|GO:0006163|GO:0019752|GO:0006096|GO:0004396|GO:0042278|GO:0033500|GO:0042593|GO:0008865|GO:0046939|GO:0019158|GO:0004340|GO:0032787|GO:0006165|GO:0046034|GO:0046031|GO:0006090 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|carbohydrate binding|intracellular|transferase activity|cellular carbohydrate metabolic process|monosaccharide binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|cytoplasm|carbohydrate metabolic process|homeostatic process|cellular homeostasis|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|nucleotide binding|generation of precursor metabolites and energy|cytosol|purine ribonucleoside triphosphate binding|glucose binding|ribose phosphate metabolic process|chemical homeostasis|purine nucleoside binding|nucleoside metabolic process|ribonucleoside binding|cellular chemical homeostasis|monosaccharide metabolic process|carbohydrate catabolic process|kinase activity|glucose 6-phosphate metabolic process|phosphate-containing compound metabolic process|purine nucleotide binding|carbohydrate phosphorylation|phosphotransferase activity, alcohol group as acceptor|ATP generation from ADP|hexose metabolic process|cellular glucose homeostasis|ribonucleotide metabolic process|nucleotide metabolic process|carbohydrate kinase activity|ATP binding|adenyl nucleotide binding|phosphorylation|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|carboxylic acid metabolic process|glycolytic process|hexokinase activity|purine nucleoside metabolic process|carbohydrate homeostasis|glucose homeostasis|fructokinase activity|nucleotide phosphorylation|mannokinase activity|glucokinase activity|monocarboxylic acid metabolic process|nucleoside diphosphate phosphorylation|ATP metabolic process|ADP metabolic process|pyruvate metabolic process K00844 hexokinase[2.7.1.1] hsa01100|hsa04910|hsa01200|hsa04066|hsa05230|hsa00010|hsa00500|hsa04930|hsa00520|hsa04973|hsa00051|hsa00052 Metabolic pathways - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Type II diabetes mellitus - Homo sapiens (human)|Amino sugar and nucleotide sugar metabolism - Homo sapiens (human)|Carbohydrate digestion and absorption - Homo sapiens (human)|Fructose and mannose metabolism - Homo sapiens (human)|Galactose metabolism - Homo sapiens (human) 10:69220303-69267559 644 750 753 2239 2570 1725 9.31014406069549 9.85398271175513 9.81476360289825 29.0016252155948 30.4839763820085 23.3716117297457 9.65963012511629 27.6190711091163 -1.51562494606783 4.72703930668824e-12 1.51743044582657e-10 DOWN ENSG00000131043 AAR2 AAR2 splicing factor homolog [Source:HGNC Symbol;Acc:HGNC:15886] GO:0009987|GO:0008152|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0022607|GO:0006139|GO:0022613|GO:0022618|GO:0010467|GO:0016070|GO:0034622|GO:0006396|GO:0016071|GO:0000387|GO:0000244|GO:0006397|GO:0008380|GO:0000375|GO:0000398 cellular process|metabolic process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|ribonucleoprotein complex assembly|gene expression|RNA metabolic process|cellular macromolecular complex assembly|RNA processing|mRNA metabolic process|spliceosomal snRNP assembly|spliceosomal tri-snRNP complex assembly|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 20:36236459-36270918 1766 1628 1191 532 612 452 39.5445720576013 33.1306899282547 24.0448530711144 10.6734597844315 11.2438592103531 9.48556324738837 32.2400383523235 10.4676274140577 1.62291898111973 4.73512239010015e-12 1.51839252238507e-10 UP ENSG00000214022 REPIN1 replication initiator 1 [Source:HGNC Symbol;Acc:HGNC:17922] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0012505|GO:0031090|GO:0006725|GO:0000808|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:1900076|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0030529|GO:0005635|GO:0006139|GO:0009725|GO:0031965|GO:0044249|GO:0010876|GO:0010033|GO:0005829|GO:0003677|GO:0034645|GO:0046872|GO:0003723|GO:0005840|GO:0005664|GO:0005811|GO:1901652|GO:0071417|GO:0006811|GO:0031981|GO:0032368|GO:0043434|GO:0006869|GO:0006259|GO:0005694|GO:0000228|GO:0043269|GO:2001273|GO:0071310|GO:0009059|GO:0008643|GO:0032870|GO:0005634|GO:0010827|GO:0006820|GO:0015711|GO:0006260|GO:1901653|GO:0022626|GO:0046324|GO:0015908|GO:0046942|GO:0071375|GO:0044070|GO:0044822|GO:2000191|GO:0032868|GO:0015718|GO:0008645|GO:0032869|GO:0015758|GO:0046323 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|origin recognition complex|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular response to insulin stimulus|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|intracellular ribonucleoprotein complex|nuclear envelope|nucleobase-containing compound metabolic process|response to hormone|nuclear membrane|cellular biosynthetic process|lipid localization|response to organic substance|cytosol|DNA binding|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|ribosome|nuclear origin of replication recognition complex|lipid particle|response to peptide|cellular response to organonitrogen compound|ion transport|nuclear lumen|regulation of lipid transport|response to peptide hormone|lipid transport|DNA metabolic process|chromosome|nuclear chromosome|regulation of ion transport|regulation of glucose import in response to insulin stimulus|cellular response to organic substance|macromolecule biosynthetic process|carbohydrate transport|cellular response to hormone stimulus|nucleus|regulation of glucose transport|anion transport|organic anion transport|DNA replication|cellular response to peptide|cytosolic ribosome|regulation of glucose import|fatty acid transport|carboxylic acid transport|cellular response to peptide hormone stimulus|regulation of anion transport|poly(A) RNA binding|regulation of fatty acid transport|response to insulin|monocarboxylic acid transport|hexose transport|cellular response to insulin stimulus|glucose transport|glucose import - - - - 7:150368189-150374044 2385 2641 2396 1031 1196 884 7.87763352417903 7.92785663818769 7.13523881356253 3.05115086661053 3.24120421996806 2.73645557788311 7.64690965864308 3.00960355482057 1.34530337201108 4.8874897145056e-12 1.56556993494474e-10 UP ENSG00000112658 SRF serum response factor [Source:HGNC Symbol;Acc:HGNC:11291] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0040013|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0044089|GO:0071704|GO:0009628|GO:0044237|GO:0048870|GO:0023051|GO:0000989|GO:0009653|GO:0000785|GO:0016043|GO:0045927|GO:0007155|GO:0043227|GO:0044708|GO:0002262|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0045058|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0007507|GO:0042127|GO:0050817|GO:0016337|GO:0050804|GO:0001824|GO:1900222|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:0021766|GO:0051130|GO:1901360|GO:0001568|GO:0009991|GO:0007275|GO:0090009|GO:0030324|GO:0003676|GO:0048513|GO:0050877|GO:0070489|GO:0034101|GO:0032535|GO:0034641|GO:0030307|GO:0030155|GO:0030900|GO:0051491|GO:0031325|GO:0046483|GO:0051128|GO:0043368|GO:0033554|GO:0001825|GO:0007420|GO:0022607|GO:0098609|GO:0050803|GO:0061061|GO:0045597|GO:0043231|GO:0019899|GO:0005737|GO:0000981|GO:0007389|GO:0003012|GO:0001763|GO:0007267|GO:0031668|GO:0009611|GO:0060322|GO:0001076|GO:0007423|GO:0097242|GO:0006928|GO:0009887|GO:0042592|GO:0001775|GO:0031589|GO:0048729|GO:0046983|GO:0048598|GO:0048568|GO:0009890|GO:0019725|GO:0048639|GO:0021988|GO:0003682|GO:0030323|GO:0048871|GO:0010646|GO:0006139|GO:0001525|GO:0000790|GO:0046649|GO:0007154|GO:0001704|GO:0051270|GO:0061029|GO:0021772|GO:0060491|GO:0061383|GO:0016477|GO:0007165|GO:0048588|GO:0048638|GO:0060438|GO:0030220|GO:0008134|GO:0009725|GO:0051271|GO:0007611|GO:0060348|GO:0008285|GO:0001666|GO:0021543|GO:0030030|GO:0060324|GO:0045061|GO:0050805|GO:0048869|GO:0030029|GO:2000145|GO:0021537|GO:0044249|GO:0031334|GO:0043254|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0048732|GO:0050878|GO:0006996|GO:1900221|GO:0051090|GO:0007568|GO:0003205|GO:0009636|GO:0007584|GO:0060560|GO:0051017|GO:0060425|GO:0000982|GO:0000902|GO:0031175|GO:0022029|GO:0003677|GO:0009743|GO:0003143|GO:0060292|GO:0031344|GO:0002040|GO:0048538|GO:0010468|GO:0006936|GO:0090132|GO:0034645|GO:0045216|GO:0030168|GO:0030218|GO:0051216|GO:0045059|GO:0048167|GO:0003723|GO:0001654|GO:0002009|GO:0001569|GO:0001944|GO:0007010|GO:0030097|GO:0072358|GO:0034097|GO:0060347|GO:0030098|GO:0007417|GO:0007612|GO:0010629|GO:0050891|GO:0010720|GO:0007498|GO:0060976|GO:0042692|GO:0048878|GO:0009798|GO:0001894|GO:0007596|GO:0051252|GO:0060541|GO:0035050|GO:0035051|GO:0048738|GO:2000144|GO:0003007|GO:0048754|GO:0061138|GO:0055006|GO:0021761|GO:0031346|GO:0000904|GO:0060055|GO:0009790|GO:0090257|GO:0000983|GO:0010628|GO:0030334|GO:0030878|GO:0051147|GO:0046716|GO:0001667|GO:0021885|GO:0031670|GO:0007613|GO:0060840|GO:0060537|GO:0007369|GO:0007160|GO:0042060|GO:0048844|GO:0001764|GO:0003705|GO:0048872|GO:0055082|GO:0051091|GO:0034329|GO:0003002|GO:0022028|GO:0001707|GO:0007569|GO:0035270|GO:0031981|GO:0050769|GO:0043589|GO:0007599|GO:0030031|GO:0008361|GO:0007159|GO:0042826|GO:0061371|GO:0005654|GO:0060433|GO:0022604|GO:0005694|GO:0000228|GO:0006461|GO:0043588|GO:0055001|GO:0030036|GO:0030336|GO:0090136|GO:0045987|GO:2000142|GO:0070925|GO:0042110|GO:0061145|GO:0060429|GO:0035556|GO:1901228|GO:0010467|GO:0030516|GO:0032990|GO:0048562|GO:0007399|GO:0060562|GO:0071310|GO:0060534|GO:0050890|GO:0031328|GO:0010770|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0030239|GO:0001228|GO:0031669|GO:0016070|GO:0072359|GO:0031667|GO:0010557|GO:0005634|GO:0001829|GO:0042803|GO:0090398|GO:1990138|GO:0061384|GO:0048332|GO:0051960|GO:0045773|GO:0051489|GO:0031490|GO:0048666|GO:0030182|GO:0055002|GO:0002521|GO:0071322|GO:0000975|GO:0045893|GO:0048863|GO:0070878|GO:0055003|GO:0010975|GO:0009792|GO:0045990|GO:0001678|GO:0045445|GO:0006939|GO:0043566|GO:0060947|GO:0006937|GO:0010769|GO:0051145|GO:0045892|GO:0043010|GO:0002011|GO:0060261|GO:0055013|GO:0032774|GO:0008306|GO:0043565|GO:2001141|GO:0035855|GO:0003256|GO:0030217|GO:0034284|GO:0001077|GO:1902679|GO:0036344|GO:0030104|GO:0002042|GO:0070486|GO:0003690|GO:0061564|GO:0001947|GO:0060532|GO:0046847|GO:0003257|GO:0009948|GO:0009855|GO:0035909|GO:0051146|GO:0010631|GO:0009952|GO:0033077|GO:0035904|GO:0001702|GO:0048745|GO:0007616|GO:0002244|GO:0048821|GO:0030099|GO:0031032|GO:0051150|GO:0014706|GO:0050772|GO:0022008|GO:0030038|GO:0048667|GO:0007264|GO:0055007|GO:0033561|GO:0007015|GO:0045214|GO:0050767|GO:0048812|GO:0007043|GO:0010976|GO:0006351|GO:0010002|GO:0006355|GO:0060218|GO:0048675|GO:0010669|GO:0033500|GO:0035886|GO:0045666|GO:0060379|GO:0071333|GO:0042593|GO:0070830|GO:0009299|GO:0045944|GO:0006366|GO:0035912|GO:1903507|GO:0006352|GO:0006940|GO:0043297|GO:0006357|GO:0007409|GO:0048699|GO:0007368|GO:1903506|GO:0044212|GO:0030219|GO:0035907|GO:0043149|GO:0043009|GO:0000122|GO:0046015|GO:0061572|GO:0043542|GO:0050770|GO:0071593|GO:0045664|GO:0007268|GO:0006367|GO:0010735|GO:0042789|GO:0000976|GO:0046016|GO:0001012|GO:0010736|GO:1902895|GO:0009749|GO:0001701|GO:0001159|GO:1902894|GO:0043534|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|growth|macromolecular complex|immune system process|behavior|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|negative regulation of locomotion|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|positive regulation of cellular component biogenesis|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cellular component organization|positive regulation of growth|cell adhesion|membrane-bounded organelle|single-organism behavior|myeloid cell homeostasis|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|immune system development|protein binding|anatomical structure development|T cell selection|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|heart development|regulation of cell proliferation|coagulation|single organismal cell-cell adhesion|modulation of synaptic transmission|blastocyst development|negative regulation of beta-amyloid clearance|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|tube development|hippocampus development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|response to extracellular stimulus|multicellular organism development|primitive streak formation|lung development|nucleic acid binding|animal organ development|neurological system process|T cell aggregation|erythrocyte homeostasis|regulation of cellular component size|cellular nitrogen compound metabolic process|positive regulation of cell growth|regulation of cell adhesion|forebrain development|positive regulation of filopodium assembly|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive T cell selection|cellular response to stress|blastocyst formation|brain development|cellular component assembly|cell-cell adhesion|regulation of synapse structure or activity|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|muscle system process|morphogenesis of a branching structure|cell-cell signaling|cellular response to extracellular stimulus|response to wounding|head development|transcription factor activity, RNA polymerase II transcription factor binding|sensory organ development|beta-amyloid clearance|movement of cell or subcellular component|organ morphogenesis|homeostatic process|cell activation|cell-substrate adhesion|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|cellular homeostasis|positive regulation of developmental growth|olfactory lobe development|chromatin binding|respiratory tube development|multicellular organismal homeostasis|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|nuclear chromatin|lymphocyte activation|cell communication|formation of primary germ layer|regulation of cellular component movement|eyelid development in camera-type eye|olfactory bulb development|regulation of cell projection assembly|trabecula morphogenesis|cell migration|signal transduction|developmental cell growth|regulation of developmental growth|trachea development|platelet formation|transcription factor binding|response to hormone|negative regulation of cellular component movement|learning or memory|bone development|negative regulation of cell proliferation|response to hypoxia|pallium development|cell projection organization|face development|thymic T cell selection|negative regulation of synaptic transmission|cellular developmental process|actin filament-based process|regulation of cell motility|telencephalon development|cellular biosynthetic process|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|gland development|regulation of body fluid levels|organelle organization|regulation of beta-amyloid clearance|regulation of sequence-specific DNA binding transcription factor activity|aging|cardiac chamber development|response to toxic substance|response to nutrient|developmental growth involved in morphogenesis|actin filament bundle assembly|lung morphogenesis|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|cell morphogenesis|neuron projection development|telencephalon cell migration|DNA binding|response to carbohydrate|embryonic heart tube morphogenesis|long term synaptic depression|regulation of cell projection organization|sprouting angiogenesis|thymus development|regulation of gene expression|muscle contraction|epithelium migration|cellular macromolecule biosynthetic process|cell-cell junction organization|platelet activation|erythrocyte differentiation|cartilage development|positive thymic T cell selection|regulation of synaptic plasticity|RNA binding|eye development|morphogenesis of an epithelium|patterning of blood vessels|vasculature development|cytoskeleton organization|hemopoiesis|cardiovascular system development|response to cytokine|heart trabecula formation|lymphocyte differentiation|central nervous system development|learning|negative regulation of gene expression|multicellular organismal water homeostasis|positive regulation of cell development|mesoderm development|coronary vasculature development|muscle cell differentiation|chemical homeostasis|axis specification|tissue homeostasis|blood coagulation|regulation of RNA metabolic process|respiratory system development|embryonic heart tube development|cardiocyte differentiation|cardiac muscle tissue development|positive regulation of DNA-templated transcription, initiation|heart morphogenesis|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|cardiac cell development|limbic system development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|angiogenesis involved in wound healing|embryo development|regulation of muscle system process|transcription factor activity, RNA polymerase II core promoter sequence-specific|positive regulation of gene expression|regulation of cell migration|thyroid gland development|regulation of muscle cell differentiation|muscle cell cellular homeostasis|ameboidal-type cell migration|forebrain cell migration|cellular response to nutrient|memory|artery development|muscle tissue development|gastrulation|cell-matrix adhesion|wound healing|artery morphogenesis|neuron migration|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|homeostasis of number of cells|cellular chemical homeostasis|positive regulation of sequence-specific DNA binding transcription factor activity|cell junction assembly|regionalization|tangential migration from the subventricular zone to the olfactory bulb|mesoderm formation|cell aging|endocrine system development|nuclear lumen|positive regulation of neurogenesis|skin morphogenesis|hemostasis|cell projection assembly|regulation of cell size|leukocyte cell-cell adhesion|histone deacetylase binding|determination of heart left/right asymmetry|nucleoplasm|bronchus development|regulation of cell morphogenesis|chromosome|nuclear chromosome|protein complex assembly|skin development|muscle cell development|actin cytoskeleton organization|negative regulation of cell migration|epithelial cell-cell adhesion|positive regulation of smooth muscle contraction|regulation of DNA-templated transcription, initiation|organelle assembly|T cell activation|lung smooth muscle development|epithelium development|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter involved in heart development|gene expression|regulation of axon extension|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|trachea cartilage development|cognition|positive regulation of cellular biosynthetic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|myofibril assembly|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|cellular response to nutrient levels|RNA metabolic process|circulatory system development|response to nutrient levels|positive regulation of macromolecule biosynthetic process|nucleus|trophectodermal cell differentiation|protein homodimerization activity|cellular senescence|neuron projection extension|heart trabecula morphogenesis|mesoderm morphogenesis|regulation of nervous system development|positive regulation of axon extension|regulation of filopodium assembly|chromatin DNA binding|neuron development|neuron differentiation|striated muscle cell development|leukocyte differentiation|cellular response to carbohydrate stimulus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|stem cell differentiation|primary miRNA binding|cardiac myofibril assembly|regulation of neuron projection development|embryo development ending in birth or egg hatching|carbon catabolite regulation of transcription|cellular glucose homeostasis|myoblast differentiation|smooth muscle contraction|structure-specific DNA binding|cardiac vascular smooth muscle cell differentiation|regulation of muscle contraction|regulation of cell morphogenesis involved in differentiation|smooth muscle cell differentiation|negative regulation of transcription, DNA-templated|camera-type eye development|morphogenesis of an epithelial sheet|positive regulation of transcription initiation from RNA polymerase II promoter|cardiac muscle cell development|RNA biosynthetic process|associative learning|sequence-specific DNA binding|regulation of RNA biosynthetic process|megakaryocyte development|regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|T cell differentiation|response to monosaccharide|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of RNA biosynthetic process|platelet morphogenesis|water homeostasis|cell migration involved in sprouting angiogenesis|leukocyte aggregation|double-stranded DNA binding|axon development|heart looping|bronchus cartilage development|filopodium assembly|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|anterior/posterior axis specification|determination of bilateral symmetry|aorta morphogenesis|striated muscle cell differentiation|epithelial cell migration|anterior/posterior pattern specification|T cell differentiation in thymus|aorta development|gastrulation with mouth forming second|smooth muscle tissue development|long-term memory|hematopoietic progenitor cell differentiation|erythrocyte development|myeloid cell differentiation|actomyosin structure organization|regulation of smooth muscle cell differentiation|striated muscle tissue development|positive regulation of axonogenesis|neurogenesis|contractile actin filament bundle assembly|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cardiac muscle cell differentiation|regulation of water loss via skin|actin filament organization|sarcomere organization|regulation of neurogenesis|neuron projection morphogenesis|cell-cell junction assembly|positive regulation of neuron projection development|transcription, DNA-templated|cardioblast differentiation|regulation of transcription, DNA-templated|hematopoietic stem cell differentiation|axon extension|epithelial structure maintenance|carbohydrate homeostasis|vascular smooth muscle cell differentiation|positive regulation of neuron differentiation|cardiac muscle cell myoblast differentiation|cellular response to glucose stimulus|glucose homeostasis|bicellular tight junction assembly|mRNA transcription|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|dorsal aorta morphogenesis|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of smooth muscle contraction|apical junction assembly|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|determination of left/right symmetry|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|megakaryocyte differentiation|dorsal aorta development|stress fiber assembly|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription by glucose|actin filament bundle organization|endothelial cell migration|regulation of axonogenesis|lymphocyte aggregation|regulation of neuron differentiation|synaptic transmission|transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|mRNA transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|positive regulation of transcription by glucose|RNA polymerase II regulatory region DNA binding|serum response element binding|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|response to glucose|in utero embryonic development|core promoter proximal region DNA binding|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|blood vessel endothelial cell migration|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K04378 serum response factor[-] hsa05166|hsa04010|hsa05203|hsa04022 HTLV-I infection - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human) 6:43171299-43181507 1676 1954 1812 738 882 725 28.2139341170593 29.8947098549379 27.5018625754704 11.1312389977494 12.1822181382209 11.4381794001381 28.5368355158225 11.5838788453695 1.30070694287724 4.91019430744434e-12 1.5711569223413e-10 UP ENSG00000108557 RAI1 retinoic acid induced 1 [Source:HGNC Symbol;Acc:HGNC:9834] GO:0032502|GO:0040007|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0043167|GO:0044237|GO:0045926|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0032922|GO:0043231|GO:0043169|GO:0005737|GO:0035264|GO:0040015|GO:0006139|GO:0048638|GO:0040014|GO:0048640|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0005739|GO:0010467|GO:0031328|GO:0009059|GO:0001501|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0008270|GO:0035326 developmental process|growth|cell|rhythmic process|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|ion binding|cellular metabolic process|negative regulation of growth|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|circadian regulation of gene expression|intracellular membrane-bounded organelle|cation binding|cytoplasm|multicellular organism growth|negative regulation of multicellular organism growth|nucleobase-containing compound metabolic process|regulation of developmental growth|regulation of multicellular organism growth|negative regulation of developmental growth|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|mitochondrion|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|skeletal system development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|zinc ion binding|enhancer binding - - - - 17:17681473-17811453 676 814 804 1951 2340 2247 3.42414188508572 3.74721981680475 3.67176647606752 8.85441057594311 9.72497730800652 10.6668640746573 3.61437605931933 9.74875065286898 -1.43147072287759 4.94032732793949e-12 1.57910633884696e-10 DOWN ENSG00000137648 TMPRSS4 transmembrane protease, serine 4 [Source:HGNC Symbol;Acc:HGNC:11878] GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0004872|GO:0071704|GO:0016787|GO:0031224|GO:0005515|GO:0006810|GO:0008233|GO:0016021|GO:0019538|GO:0038024|GO:0017171|GO:0016192|GO:0006508|GO:0008236|GO:0005044|GO:0004252|GO:0004175|GO:0006897|GO:0006898 membrane|metabolic process|binding|catalytic activity|receptor activity|organic substance metabolic process|hydrolase activity|intrinsic component of membrane|protein binding|transport|peptidase activity|integral component of membrane|protein metabolic process|cargo receptor activity|serine hydrolase activity|vesicle-mediated transport|proteolysis|serine-type peptidase activity|scavenger receptor activity|serine-type endopeptidase activity|endopeptidase activity|endocytosis|receptor-mediated endocytosis K09635 transmembrane protease serine 4 [EC:3.4.21.-][-] hsa05164 Influenza A - Homo sapiens (human) 11:118077012-118121890 81 89 168 489 436 819 0.298050185865138 0.297627981153509 0.557347364858142 1.61216078725777 1.3163046407188 2.82432717380046 0.38434184395893 1.91759753392568 -2.31883800000243 4.95265943537715e-12 1.58135502442513e-10 DOWN ENSG00000141447 OSBPL1A oxysterol binding protein like 1A [Source:HGNC Symbol;Acc:HGNC:16398] GO:0002376|GO:0005623|GO:0016020|GO:0005576|GO:0008152|GO:0005488|GO:0036094|GO:1903561|GO:0097159|GO:0019882|GO:0043229|GO:0071704|GO:0043167|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019884|GO:0006810|GO:1901360|GO:0005496|GO:0043168|GO:0044281|GO:0005543|GO:0031982|GO:0043231|GO:0043178|GO:0005774|GO:0005737|GO:0006629|GO:0070062|GO:0002504|GO:0048002|GO:0010876|GO:0005768|GO:0016192|GO:0006066|GO:0005773|GO:0032934|GO:0005770|GO:0031981|GO:0006869|GO:0005654|GO:0008202|GO:0005634|GO:0002495|GO:0000323|GO:0019886|GO:0016125|GO:0015485|GO:0005765|GO:0005764|GO:0008203 immune system process|cell|membrane|extracellular region|metabolic process|binding|small molecule binding|extracellular vesicle|organic cyclic compound binding|antigen processing and presentation|intracellular organelle|organic substance metabolic process|ion binding|membrane-bounded organelle|lipid binding|intracellular|protein binding|endomembrane system|organelle membrane|antigen processing and presentation of exogenous antigen|transport|organic cyclic compound metabolic process|steroid binding|anion binding|small molecule metabolic process|phospholipid binding|vesicle|intracellular membrane-bounded organelle|alcohol binding|vacuolar membrane|cytoplasm|lipid metabolic process|extracellular exosome|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|antigen processing and presentation of peptide antigen|lipid localization|endosome|vesicle-mediated transport|alcohol metabolic process|vacuole|sterol binding|late endosome|nuclear lumen|lipid transport|nucleoplasm|steroid metabolic process|nucleus|antigen processing and presentation of peptide antigen via MHC class II|lytic vacuole|antigen processing and presentation of exogenous peptide antigen via MHC class II|sterol metabolic process|cholesterol binding|lysosomal membrane|lysosome|cholesterol metabolic process - - - - 18:24162044-24397880 368 353 687 1441 1643 2065 2.23769826029441 1.95078209048134 3.7663847352834 7.85082943979753 8.1970887136634 11.7680108563643 2.65162169535305 9.27197633660841 -1.8060019223495 5.00024945713359e-12 1.59484452236395e-10 DOWN ENSG00000141867 BRD4 bromodomain containing 4 [Source:HGNC Symbol;Acc:HGNC:13575] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0016032|GO:0051726|GO:0007049|GO:0006725|GO:0042393|GO:0022402|GO:1901360|GO:0002039|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0045786|GO:0043231|GO:0005737|GO:0009611|GO:0009966|GO:0045787|GO:0003682|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009967|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:1902533|GO:0032268|GO:0010468|GO:0000075|GO:0034645|GO:0090068|GO:1903047|GO:0043412|GO:0050727|GO:0070577|GO:0051252|GO:0006325|GO:0044770|GO:0010628|GO:2000002|GO:0036211|GO:0000278|GO:0006954|GO:0031981|GO:2001020|GO:0007346|GO:0010564|GO:0005654|GO:0005694|GO:0000228|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:1902531|GO:0016070|GO:0045931|GO:0010557|GO:0005634|GO:0006974|GO:0010948|GO:0000083|GO:0045893|GO:0043122|GO:0000086|GO:0032774|GO:0000793|GO:0044772|GO:2001141|GO:0016310|GO:2000001|GO:0000077|GO:1901990|GO:0000794|GO:1901989|GO:0043123|GO:1901992|GO:0007249|GO:0016568|GO:1901987|GO:0006464|GO:0006351|GO:0006355|GO:1901976|GO:0045944|GO:0006366|GO:0032784|GO:0010389|GO:0032786|GO:0006357|GO:0006468|GO:1903506|GO:0042325|GO:0006354|GO:0001932|GO:0000082|GO:1902751|GO:0010971|GO:1902749|GO:0006338|GO:0070816|GO:0006368|GO:0032968|GO:0034243|GO:1901407 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|viral process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|histone binding|cell cycle process|organic cyclic compound metabolic process|p53 binding|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|response to wounding|regulation of signal transduction|positive regulation of cell cycle|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|mitotic cell cycle process|macromolecule modification|regulation of inflammatory response|lysine-acetylated histone binding|regulation of RNA metabolic process|chromatin organization|cell cycle phase transition|positive regulation of gene expression|negative regulation of DNA damage checkpoint|protein modification process|mitotic cell cycle|inflammatory response|nuclear lumen|regulation of response to DNA damage stimulus|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|chromosome|nuclear chromosome|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of mitotic cell cycle|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|negative regulation of cell cycle process|regulation of transcription involved in G1/S transition of mitotic cell cycle|positive regulation of transcription, DNA-templated|regulation of I-kappaB kinase/NF-kappaB signaling|G2/M transition of mitotic cell cycle|RNA biosynthetic process|condensed chromosome|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|phosphorylation|regulation of DNA damage checkpoint|DNA damage checkpoint|regulation of mitotic cell cycle phase transition|condensed nuclear chromosome|positive regulation of cell cycle phase transition|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of mitotic cell cycle phase transition|I-kappaB kinase/NF-kappaB signaling|chromatin modification|regulation of cell cycle phase transition|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of cell cycle checkpoint|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|regulation of G2/M transition of mitotic cell cycle|positive regulation of DNA-templated transcription, elongation|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|DNA-templated transcription, elongation|regulation of protein phosphorylation|G1/S transition of mitotic cell cycle|positive regulation of cell cycle G2/M phase transition|positive regulation of G2/M transition of mitotic cell cycle|regulation of cell cycle G2/M phase transition|chromatin remodeling|phosphorylation of RNA polymerase II C-terminal domain|transcription elongation from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription elongation from RNA polymerase II promoter|regulation of phosphorylation of RNA polymerase II C-terminal domain - - - - 19:15235519-15332545 467 530 388 1431 1620 1434 2.38841233671406 2.46347559476701 1.78911262317891 6.55736783062022 6.79790759779449 6.8733769215867 2.21366685155333 6.74288411666714 -1.60692768535907 5.1010794518989e-12 1.62526815322294e-10 DOWN ENSG00000187676 B3GLCT beta 3-glucosyltransferase [Source:HGNC Symbol;Acc:HGNC:20207] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0044281|GO:0043231|GO:0005737|GO:0005975|GO:0005783|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0034645|GO:0043412|GO:0006493|GO:0009100|GO:0036211|GO:0005996|GO:0070085|GO:1901137|GO:0044267|GO:0009059|GO:0019318|GO:0009101|GO:0043413|GO:0036065|GO:0036066|GO:0006464|GO:0006004|GO:0043687 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|protein glycosylation|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|monosaccharide metabolic process|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|hexose metabolic process|glycoprotein biosynthetic process|macromolecule glycosylation|fucosylation|protein O-linked fucosylation|cellular protein modification process|fucose metabolic process|post-translational protein modification K13675 UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase [EC:2.4.1.-][-] hsa00514 Other types of O-glycan biosynthesis - Homo sapiens (human) 13:31199936-31332276 83 99 125 411 380 327 1.25613690606926 1.36167593720277 1.70561037234726 5.57309902129791 4.71854826290733 4.63803784590918 1.4411410718731 4.97656171003814 -1.78793776683316 5.1450122659783e-12 1.63751808303322e-10 DOWN ENSG00000101846 STS steroid sulfatase (microsomal), isozyme S [Source:HGNC Symbol;Acc:HGNC:11425] GO:0032502|GO:0000003|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0044708|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0008284|GO:0042127|GO:0044255|GO:0009888|GO:1901360|GO:0007275|GO:0048513|GO:0050877|GO:0016788|GO:0044281|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0005635|GO:0009268|GO:0007565|GO:0006629|GO:0005783|GO:0009725|GO:0007611|GO:0016021|GO:0019538|GO:0010033|GO:0005794|GO:0005768|GO:0006665|GO:0046872|GO:0033993|GO:0043412|GO:0016042|GO:0008484|GO:1901652|GO:0005773|GO:0006643|GO:0036211|GO:0043434|GO:0043588|GO:0008202|GO:0014070|GO:0060429|GO:0044267|GO:0005788|GO:0050890|GO:0005634|GO:0048545|GO:0006687|GO:0000323|GO:0043627|GO:0008544|GO:0006664|GO:0006706|GO:0004773|GO:0006464|GO:0005764|GO:0043687 developmental process|reproduction|behavior|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|single-organism behavior|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|positive regulation of cell proliferation|regulation of cell proliferation|cellular lipid metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|neurological system process|hydrolase activity, acting on ester bonds|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|nuclear envelope|response to pH|female pregnancy|lipid metabolic process|endoplasmic reticulum|response to hormone|learning or memory|integral component of membrane|protein metabolic process|response to organic substance|Golgi apparatus|endosome|sphingolipid metabolic process|metal ion binding|response to lipid|macromolecule modification|lipid catabolic process|sulfuric ester hydrolase activity|response to peptide|vacuole|membrane lipid metabolic process|protein modification process|response to peptide hormone|skin development|steroid metabolic process|response to organic cyclic compound|epithelium development|cellular protein metabolic process|endoplasmic reticulum lumen|cognition|nucleus|response to steroid hormone|glycosphingolipid metabolic process|lytic vacuole|response to estrogen|epidermis development|glycolipid metabolic process|steroid catabolic process|steryl-sulfatase activity|cellular protein modification process|lysosome|post-translational protein modification K01131 steryl-sulfatase[3.1.6.2] hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) X:7219456-7354810 61 67 101 316 272 389 0.661705145400891 0.660524407906077 0.987795795243631 3.07125350765638 2.4208553450573 3.95466933330023 0.770008449516866 3.14892606200464 -2.03191370073548 5.15457845645642e-12 1.63881560424973e-10 DOWN ENSG00000010539 ZNF200 zinc finger protein 200 [Source:HGNC Symbol;Acc:HGNC:12993] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 16:3222325-3236221 900 914 590 249 295 248 3.54867270880986 3.27528734390107 2.09743865399972 0.879670417742445 0.954362916726279 0.916438675553832 2.97379956890355 0.916824003340852 1.69759069361786 5.37868506541621e-12 1.70824748875463e-10 UP ENSG00000253873 PCDHGA11 protocadherin gamma subfamily A, 11 [Source:HGNC Symbol;Acc:HGNC:8698] GO:0005623|GO:0016020|GO:0005488|GO:0043167|GO:0007155|GO:0071944|GO:0031224|GO:0005886|GO:0098609|GO:0043169|GO:0016021|GO:0098742|GO:0046872|GO:0005509|GO:0007156 cell|membrane|binding|ion binding|cell adhesion|cell periphery|intrinsic component of membrane|plasma membrane|cell-cell adhesion|cation binding|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|metal ion binding|calcium ion binding|homophilic cell adhesion via plasma membrane adhesion molecules - - - - 5:141421047-141512979 7 6 7 57 63 45 0.0476352160761524 0.0371066678667068 0.0429449725637446 0.347533662459982 0.351747384453392 0.286985197282282 0.0425622855022013 0.328755414731885 -2.94936712874026 5.69793119788149e-12 1.80771560022905e-10 DOWN ENSG00000112599 GUCA1B guanylate cyclase activator 1B [Source:HGNC Symbol;Acc:HGNC:4679] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0051606|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0005886|GO:0005929|GO:0031090|GO:0019222|GO:0006725|GO:0009314|GO:0006810|GO:1901360|GO:0050877|GO:0034641|GO:0008047|GO:0060170|GO:0044281|GO:0019637|GO:0031325|GO:0046483|GO:0009582|GO:0043169|GO:0007267|GO:0001917|GO:0009966|GO:0072372|GO:0097381|GO:0010646|GO:0006139|GO:0043085|GO:0055086|GO:0007154|GO:0001750|GO:0007165|GO:0050790|GO:0031253|GO:0044249|GO:0031323|GO:0050878|GO:0007186|GO:0046872|GO:0007166|GO:0051349|GO:0009583|GO:0007589|GO:0019693|GO:0008277|GO:0030249|GO:0030250|GO:0031279|GO:0007602|GO:0007600|GO:0022400|GO:0071478|GO:0006796|GO:1901137|GO:0051174|GO:0046903|GO:0031281|GO:0031328|GO:0009416|GO:0031513|GO:0050953|GO:0009259|GO:0009117|GO:0046390|GO:0016056|GO:0008048|GO:0005509|GO:0031284|GO:0007167|GO:0009584|GO:0071482|GO:0006163|GO:0007603|GO:0009165|GO:0031282|GO:0006164|GO:0030801|GO:0007168|GO:0009187|GO:0007601|GO:0030802|GO:0009190|GO:0030826|GO:0046068|GO:0030828|GO:0009152|GO:0030823|GO:0052652|GO:0030825|GO:0006182 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|detection of stimulus|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|plasma membrane|cilium|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|response to radiation|transport|organic cyclic compound metabolic process|neurological system process|cellular nitrogen compound metabolic process|enzyme activator activity|ciliary membrane|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|detection of abiotic stimulus|cation binding|cell-cell signaling|photoreceptor inner segment|regulation of signal transduction|primary cilium|photoreceptor disc membrane|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|cell communication|photoreceptor outer segment|signal transduction|regulation of catalytic activity|cell projection membrane|cellular biosynthetic process|regulation of cellular metabolic process|regulation of body fluid levels|G-protein coupled receptor signaling pathway|metal ion binding|cell surface receptor signaling pathway|positive regulation of lyase activity|detection of light stimulus|body fluid secretion|ribose phosphate metabolic process|regulation of G-protein coupled receptor protein signaling pathway|guanylate cyclase regulator activity|guanylate cyclase activator activity|regulation of cyclase activity|phototransduction|sensory perception|regulation of rhodopsin mediated signaling pathway|cellular response to radiation|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|secretion|positive regulation of cyclase activity|positive regulation of cellular biosynthetic process|response to light stimulus|nonmotile primary cilium|sensory perception of light stimulus|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|rhodopsin mediated signaling pathway|calcium sensitive guanylate cyclase activator activity|calcium ion binding|positive regulation of guanylate cyclase activity|enzyme linked receptor protein signaling pathway|detection of visible light|cellular response to light stimulus|purine nucleotide metabolic process|phototransduction, visible light|nucleotide biosynthetic process|regulation of guanylate cyclase activity|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|receptor guanylyl cyclase signaling pathway|cyclic nucleotide metabolic process|visual perception|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|regulation of cGMP biosynthetic process|cGMP metabolic process|positive regulation of cGMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cGMP metabolic process|cyclic purine nucleotide metabolic process|positive regulation of cGMP metabolic process|cGMP biosynthetic process K08328 guanylate cyclase activator 1[-] hsa04744 Phototransduction - Homo sapiens (human) 6:42184401-42194916 58 50 59 11 8 10 3.68620434307302 2.88801896132388 3.38077712962757 0.626376747142101 0.417189089513046 0.595622615029275 3.31833347800816 0.546396150561474 2.6024396533393 5.76536179171069e-12 1.82522917210743e-10 UP ENSG00000115221 ITGB6 integrin subunit beta 6 [Source:HGNC Symbol;Acc:HGNC:6161] GO:0040011|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0004872|GO:0044877|GO:0050794|GO:0006950|GO:0009986|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0016032|GO:0009897|GO:0098797|GO:0005102|GO:0043062|GO:0006952|GO:0001618|GO:0031982|GO:0005887|GO:0043235|GO:0032403|GO:0031589|GO:0050839|GO:0031226|GO:0007154|GO:0007165|GO:0070062|GO:0016021|GO:0051701|GO:0007166|GO:0007160|GO:0005178|GO:0006954|GO:0008305|GO:0019058|GO:0030198|GO:0046718|GO:0007229|GO:0030260 locomotion|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|receptor activity|macromolecular complex binding|regulation of cellular process|response to stress|cell surface|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|protein complex|viral process|external side of plasma membrane|plasma membrane protein complex|receptor binding|extracellular structure organization|defense response|virus receptor activity|vesicle|integral component of plasma membrane|receptor complex|protein complex binding|cell-substrate adhesion|cell adhesion molecule binding|intrinsic component of plasma membrane|cell communication|signal transduction|extracellular exosome|integral component of membrane|interaction with host|cell surface receptor signaling pathway|cell-matrix adhesion|integrin binding|inflammatory response|integrin complex|viral life cycle|extracellular matrix organization|viral entry into host cell|integrin-mediated signaling pathway|entry into host cell K06589 integrin beta 6[-] hsa04151|hsa04810|hsa04510|hsa05414|hsa05410|hsa04512|hsa05412 PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 2:160099666-160271888 94 139 285 704 791 1171 0.503810139556903 0.677069663104147 1.37719686364679 3.38071264709309 3.47842049092564 5.88197750786963 0.852692222102613 4.24703688196279 -2.31635963519959 5.76351578509833e-12 1.82522917210743e-10 DOWN ENSG00000144681 STAC SH3 and cysteine rich domain [Source:HGNC Symbol;Acc:HGNC:11353] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0043167|GO:0009628|GO:0005622|GO:0005515|GO:0033554|GO:0043169|GO:0005737|GO:0009408|GO:0007154|GO:0007165|GO:0009266|GO:0005829|GO:0046872|GO:0034605|GO:0035556 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|ion binding|response to abiotic stimulus|intracellular|protein binding|cellular response to stress|cation binding|cytoplasm|response to heat|cell communication|signal transduction|response to temperature stimulus|cytosol|metal ion binding|cellular response to heat|intracellular signal transduction - - - - 3:36380344-36548007 36 44 71 194 267 217 0.41467851946454 0.460615745233522 0.737362248695009 2.0021984524432 2.52339974106738 2.34258918457503 0.537552171131024 2.2893957926952 -2.0904902140967 5.80528177975004e-12 1.83592036284595e-10 DOWN ENSG00000197872 FAM49A family with sequence similarity 49 member A [Source:HGNC Symbol;Acc:HGNC:25373] GO:0005623|GO:0005622 cell|intracellular - - - - 2:16549459-16666331 30 31 40 208 142 353 0.364054408885546 0.34190028977681 0.437648881714668 2.2615832071946 1.41386737256701 4.0147246220366 0.381201193459008 2.56339173393274 -2.74942942497607 5.83223034151301e-12 1.84249105413259e-10 DOWN ENSG00000131016 AKAP12 A-kinase anchoring protein 12 [Source:HGNC Symbol;Acc:HGNC:370] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0030055|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0071944|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0005938|GO:0034641|GO:0005924|GO:0044281|GO:0005912|GO:0019637|GO:0031325|GO:0046483|GO:0019899|GO:0005737|GO:0051018|GO:0009966|GO:0045184|GO:0010646|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0009967|GO:0044249|GO:0031323|GO:1902533|GO:0007186|GO:0019693|GO:0015031|GO:0046907|GO:0008179|GO:0034613|GO:0006796|GO:0035556|GO:1901137|GO:0051174|GO:0031328|GO:1902531|GO:0005856|GO:0005925|GO:0010739|GO:0090036|GO:0010737|GO:0009259|GO:0009117|GO:0046390|GO:0006605|GO:0006886|GO:0070528|GO:0006163|GO:0009165|GO:0010738|GO:0006164|GO:0030801|GO:0009187|GO:0030802|GO:0009190|GO:0046058|GO:0030819|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030816|GO:0006171 signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell-substrate junction|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|cell periphery|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cell cortex|cellular nitrogen compound metabolic process|cell-substrate adherens junction|small molecule metabolic process|adherens junction|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|enzyme binding|cytoplasm|protein kinase A binding|regulation of signal transduction|establishment of protein localization|regulation of cell communication|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|signal transduction|establishment of localization in cell|positive regulation of signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|G-protein coupled receptor signaling pathway|ribose phosphate metabolic process|protein transport|intracellular transport|adenylate cyclase binding|cellular protein localization|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|positive regulation of cellular biosynthetic process|regulation of intracellular signal transduction|cytoskeleton|focal adhesion|positive regulation of protein kinase A signaling|regulation of protein kinase C signaling|protein kinase A signaling|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|protein targeting|intracellular protein transport|protein kinase C signaling|purine nucleotide metabolic process|nucleotide biosynthetic process|regulation of protein kinase A signaling|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|cyclic nucleotide metabolic process|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|cAMP metabolic process|positive regulation of cAMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|positive regulation of cAMP metabolic process|cAMP biosynthetic process - - - - 6:151239999-151358557 1873 2331 3075 970 1093 996 12.3938408606768 14.0181397679061 18.3454072629404 5.75092378352144 5.93411904530867 6.17670003486947 14.9191292971744 5.95391428789986 1.32525298228818 5.85540394018051e-12 1.84785654577324e-10 UP ENSG00000122550 KLHL7 kelch like family member 7 [Source:HGNC Symbol;Acc:HGNC:15646] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0042802|GO:0043231|GO:0005737|GO:0046983|GO:0019787|GO:0000151|GO:0019538|GO:0005730|GO:0043412|GO:0030163|GO:0004842|GO:0031461|GO:0044265|GO:0036211|GO:0031981|GO:1990234|GO:0006508|GO:0005654|GO:0044267|GO:0005634|GO:0042803|GO:0044257|GO:0051603|GO:0006464|GO:0031463|GO:0019941|GO:0032446|GO:0006511|GO:0042787|GO:0016567 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|transferase activity|identical protein binding|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|nucleolus|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|cellular macromolecule catabolic process|protein modification process|nuclear lumen|transferase complex|proteolysis|nucleoplasm|cellular protein metabolic process|nucleus|protein homodimerization activity|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|cellular protein modification process|Cul3-RING ubiquitin ligase complex|modification-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - 7:23105758-23177914 171 218 328 718 837 802 0.921459776201863 1.06761878976439 1.59356037694006 3.46658896431921 3.70061245380804 4.05026791225856 1.19421298096877 3.73915644346194 -1.64665267786803 5.94509613292036e-12 1.87418056971705e-10 DOWN ENSG00000204179 PTPN20 protein tyrosine phosphatase, non-receptor type 20 [Source:HGNC Symbol;Acc:HGNC:23423] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0016788|GO:0005874|GO:0043231|GO:0005737|GO:0019538|GO:0043412|GO:0005815|GO:0036211|GO:0006796|GO:0044267|GO:0005856|GO:0005634|GO:0042578|GO:0016311|GO:0015630|GO:0016791|GO:0006464|GO:0006470|GO:0004721|GO:0035335|GO:0004725 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|hydrolase activity, acting on ester bonds|microtubule|intracellular membrane-bounded organelle|cytoplasm|protein metabolic process|macromolecule modification|microtubule organizing center|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|cytoskeleton|nucleus|phosphoric ester hydrolase activity|dephosphorylation|microtubule cytoskeleton|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity - - - - 10:46911396-47002488 79 85 24 512 506 454 0.631575879998438 0.617591670589826 0.172988980511685 3.66748491468067 3.31909162563459 3.40162028774929 0.474052177033316 3.46273227602152 -2.86879308403227 5.9571762175139e-12 1.87600779322426e-10 DOWN ENSG00000121964 GTDC1 glycosyltransferase like domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20887] GO:0008152|GO:0003824|GO:0016740|GO:0016757 metabolic process|catalytic activity|transferase activity|transferase activity, transferring glycosyl groups - - - - 2:143938068-144332568 28 32 67 216 220 197 0.0903149121521897 0.0938072807355323 0.194848580084323 0.624250585298312 0.582233859571768 0.595527301626526 0.126323590990682 0.600670582165535 -2.24944992135143 6.04151084462167e-12 1.90056127244821e-10 DOWN ENSG00000163050 ADCK3 aarF domain containing kinase 3 [Source:HGNC Symbol;Acc:HGNC:16812] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0016740|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0051186|GO:0042180|GO:0000166|GO:0016021|GO:0044249|GO:0035639|GO:0001883|GO:0032549|GO:0043531|GO:0005739|GO:0016301|GO:0006796|GO:1901661|GO:0017076|GO:0005524|GO:0030554|GO:0016310|GO:0009108|GO:0006743|GO:0006744 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|transferase activity|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|cofactor metabolic process|cellular ketone metabolic process|nucleotide binding|integral component of membrane|cellular biosynthetic process|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|ADP binding|mitochondrion|kinase activity|phosphate-containing compound metabolic process|quinone metabolic process|purine nucleotide binding|ATP binding|adenyl nucleotide binding|phosphorylation|coenzyme biosynthetic process|ubiquinone metabolic process|ubiquinone biosynthetic process - - - - 1:226897536-226987545 1686 1728 2004 740 882 775 10.1846586721019 9.48664215980047 10.9144217577905 4.00514329408681 4.37145009537184 4.38752089598788 10.195240863231 4.25470476181551 1.26076492906475 6.32002582265386e-12 1.98399632922722e-10 UP ENSG00000177463 NR2C2 nuclear receptor subfamily 2 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7972] GO:0032502|GO:0004871|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0004872|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0048520|GO:0044702|GO:0051321|GO:0071704|GO:0009056|GO:0043167|GO:0019953|GO:0044237|GO:0050795|GO:0006914|GO:0038023|GO:0000989|GO:0016043|GO:0043227|GO:0009893|GO:0032504|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0007049|GO:0045595|GO:0003712|GO:0006725|GO:0003707|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0030902|GO:0031325|GO:0046483|GO:0033554|GO:0007420|GO:0061061|GO:0045597|GO:0043231|GO:0043169|GO:0060322|GO:0046983|GO:0006139|GO:0007154|GO:0022037|GO:0007276|GO:0007165|GO:0000422|GO:0009725|GO:0016236|GO:0021549|GO:0048869|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0040019|GO:0031323|GO:0006996|GO:0003713|GO:0000165|GO:0003677|GO:0051149|GO:0010468|GO:0034645|GO:1903008|GO:0048232|GO:0046872|GO:0033993|GO:0000423|GO:0043412|GO:0007417|GO:0007005|GO:0042692|GO:0046982|GO:0051252|GO:0009790|GO:0010628|GO:0051147|GO:0036211|GO:0031981|GO:0031098|GO:0005654|GO:0014070|GO:0006796|GO:0035556|GO:0044267|GO:0010467|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0009755|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0045995|GO:0043401|GO:0007283|GO:0045893|GO:0045445|GO:0045663|GO:0032774|GO:0043565|GO:2001141|GO:0016310|GO:0071383|GO:0071407|GO:0045661|GO:0046914|GO:0006464|GO:0098779|GO:0071396|GO:0051403|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006352|GO:0006357|GO:0038066|GO:0006468|GO:1903506|GO:0008270|GO:0006367 developmental process|signal transducer activity|reproduction|behavior|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of behavior|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|catabolic process|ion binding|sexual reproduction|cellular metabolic process|regulation of behavior|autophagy|signaling receptor activity|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|cell cycle|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|steroid hormone receptor activity|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|hindbrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|brain development|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|head development|protein dimerization activity|nucleobase-containing compound metabolic process|cell communication|metencephalon development|gamete generation|signal transduction|mitophagy|response to hormone|macroautophagy|cerebellum development|cellular developmental process|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|positive regulation of embryonic development|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|MAPK cascade|DNA binding|positive regulation of muscle cell differentiation|regulation of gene expression|cellular macromolecule biosynthetic process|organelle disassembly|male gamete generation|metal ion binding|response to lipid|macromitophagy|macromolecule modification|central nervous system development|mitochondrion organization|muscle cell differentiation|protein heterodimerization activity|regulation of RNA metabolic process|embryo development|positive regulation of gene expression|regulation of muscle cell differentiation|protein modification process|nuclear lumen|stress-activated protein kinase signaling cascade|nucleoplasm|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|regulation of embryonic development|steroid hormone mediated signaling pathway|spermatogenesis|positive regulation of transcription, DNA-templated|myoblast differentiation|positive regulation of myoblast differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|phosphorylation|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|regulation of myoblast differentiation|transition metal ion binding|cellular protein modification process|mitophagy in response to mitochondrial depolarization|cellular response to lipid|stress-activated MAPK cascade|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|p38MAPK cascade|protein phosphorylation|regulation of nucleic acid-templated transcription|zinc ion binding|transcription initiation from RNA polymerase II promoter - - - - 3:14947584-15053600 65 119 120 393 442 355 0.30843989434171 0.513196442749523 0.513394109783619 1.67088008845666 1.72085902023462 1.57874832713536 0.445010148958284 1.65682914527555 -1.89651469348337 6.31983926488897e-12 1.98399632922722e-10 DOWN ENSG00000142871 CYR61 cysteine-rich, angiogenic inducer, 61 [Source:HGNC Symbol;Acc:HGNC:2654] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0000003|GO:0023052|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050840|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0005578|GO:0006807|GO:0006950|GO:0016049|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0008284|GO:0051272|GO:0042127|GO:0044255|GO:0003179|GO:0060674|GO:0001890|GO:0016337|GO:0008201|GO:0006935|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0019838|GO:0060713|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0033687|GO:0060411|GO:0048513|GO:0060710|GO:0005102|GO:0034641|GO:0043168|GO:0043062|GO:0030155|GO:0061036|GO:0031325|GO:0046483|GO:0051128|GO:1902742|GO:2000147|GO:0090287|GO:0010942|GO:0098609|GO:0045597|GO:0048608|GO:0007267|GO:0009611|GO:0003170|GO:0060669|GO:0006928|GO:0009887|GO:0032403|GO:0072593|GO:0031589|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0050839|GO:0060561|GO:0060548|GO:0010646|GO:0006139|GO:0001892|GO:0043085|GO:0001525|GO:0007154|GO:0045778|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0030278|GO:0003279|GO:0001503|GO:0045785|GO:0008219|GO:0050790|GO:0048869|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0005539|GO:0010033|GO:0001558|GO:0031323|GO:0060711|GO:0003205|GO:0000165|GO:0032268|GO:0003278|GO:0010468|GO:0071773|GO:0034645|GO:0006665|GO:0033688|GO:0051216|GO:0005520|GO:0007166|GO:0002009|GO:0001944|GO:0043412|GO:0061458|GO:0072358|GO:0051345|GO:0010623|GO:0043069|GO:0051252|GO:0003007|GO:0045667|GO:0046889|GO:0009790|GO:0006643|GO:0010628|GO:0030334|GO:2000303|GO:0003181|GO:0044319|GO:0051347|GO:0036211|GO:0042060|GO:0005178|GO:0001649|GO:0060413|GO:0033690|GO:0002041|GO:0003231|GO:0010810|GO:0051247|GO:0070848|GO:0006508|GO:0003209|GO:0003171|GO:0045669|GO:0003283|GO:0032270|GO:0012501|GO:0060429|GO:0006796|GO:0043603|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0008610|GO:0019216|GO:0071310|GO:0030198|GO:0046890|GO:0031328|GO:0030510|GO:0051246|GO:0009059|GO:0010811|GO:0030154|GO:0001501|GO:0061448|GO:0003281|GO:0030335|GO:0061035|GO:0043068|GO:1902531|GO:0016070|GO:0060716|GO:0072359|GO:0010557|GO:0043067|GO:0045893|GO:0006672|GO:0060591|GO:0009792|GO:0031401|GO:0043065|GO:2000304|GO:0043408|GO:0002011|GO:0032774|GO:0030162|GO:2001141|GO:0045862|GO:0071363|GO:0016310|GO:0052547|GO:0070371|GO:0030509|GO:0007167|GO:0042981|GO:0043066|GO:0030148|GO:0006464|GO:0010952|GO:0060193|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0030513|GO:0033674|GO:0046513|GO:0045944|GO:0006366|GO:0045859|GO:0010950|GO:0045860|GO:0006357|GO:0010517|GO:0043281|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0043009|GO:0043280|GO:0001934|GO:0007178|GO:0010518|GO:0070372|GO:0042327|GO:0052548|GO:2001056|GO:2000116|GO:0001701 locomotion|developmental process|extracellular matrix|growth|reproduction|signaling|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|extracellular matrix binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|nitrogen compound metabolic process|response to stress|cell growth|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|cellular lipid metabolic process|heart valve morphogenesis|placenta blood vessel development|placenta development|single organismal cell-cell adhesion|heparin binding|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|growth factor binding|labyrinthine layer morphogenesis|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|osteoblast proliferation|cardiac septum morphogenesis|animal organ development|chorio-allantoic fusion|receptor binding|cellular nitrogen compound metabolic process|anion binding|extracellular structure organization|regulation of cell adhesion|positive regulation of cartilage development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|apoptotic process involved in development|positive regulation of cell motility|regulation of cellular response to growth factor stimulus|positive regulation of cell death|cell-cell adhesion|positive regulation of cell differentiation|reproductive structure development|cell-cell signaling|response to wounding|heart valve development|embryonic placenta morphogenesis|movement of cell or subcellular component|organ morphogenesis|protein complex binding|reactive oxygen species metabolic process|cell-substrate adhesion|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|cell adhesion molecule binding|apoptotic process involved in morphogenesis|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|positive regulation of catalytic activity|angiogenesis|cell communication|positive regulation of ossification|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|regulation of ossification|cardiac septum development|ossification|positive regulation of cell adhesion|cell death|regulation of catalytic activity|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|glycosaminoglycan binding|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|labyrinthine layer development|cardiac chamber development|MAPK cascade|regulation of cellular protein metabolic process|apoptotic process involved in heart morphogenesis|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|sphingolipid metabolic process|regulation of osteoblast proliferation|cartilage development|insulin-like growth factor binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|vasculature development|macromolecule modification|reproductive system development|cardiovascular system development|positive regulation of hydrolase activity|developmental programmed cell death|negative regulation of programmed cell death|regulation of RNA metabolic process|heart morphogenesis|regulation of osteoblast differentiation|positive regulation of lipid biosynthetic process|embryo development|membrane lipid metabolic process|positive regulation of gene expression|regulation of cell migration|regulation of ceramide biosynthetic process|atrioventricular valve morphogenesis|wound healing, spreading of cells|positive regulation of transferase activity|protein modification process|wound healing|integrin binding|osteoblast differentiation|atrial septum morphogenesis|positive regulation of osteoblast proliferation|intussusceptive angiogenesis|cardiac ventricle development|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|response to growth factor|proteolysis|cardiac atrium morphogenesis|atrioventricular valve development|positive regulation of osteoblast differentiation|atrial septum development|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|cellular response to organic substance|extracellular matrix organization|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|regulation of BMP signaling pathway|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of cell-substrate adhesion|cell differentiation|skeletal system development|connective tissue development|ventricular septum development|positive regulation of cell migration|regulation of cartilage development|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|labyrinthine layer blood vessel development|circulatory system development|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|positive regulation of transcription, DNA-templated|ceramide metabolic process|chondroblast differentiation|embryo development ending in birth or egg hatching|positive regulation of protein modification process|positive regulation of apoptotic process|positive regulation of ceramide biosynthetic process|regulation of MAPK cascade|morphogenesis of an epithelial sheet|RNA biosynthetic process|regulation of proteolysis|regulation of RNA biosynthetic process|positive regulation of proteolysis|cellular response to growth factor stimulus|phosphorylation|regulation of peptidase activity|ERK1 and ERK2 cascade|BMP signaling pathway|enzyme linked receptor protein signaling pathway|regulation of apoptotic process|negative regulation of apoptotic process|sphingolipid biosynthetic process|cellular protein modification process|positive regulation of peptidase activity|positive regulation of lipase activity|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of BMP signaling pathway|positive regulation of kinase activity|ceramide biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|positive regulation of endopeptidase activity|positive regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|regulation of phospholipase activity|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|chordate embryonic development|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|positive regulation of phospholipase activity|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|regulation of endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|in utero embryonic development - - - - 1:85580761-85583962 1436 1286 1585 630 656 514 32.3703317147663 26.3459503417192 32.2133766267745 12.7242162714636 12.1328964160571 10.8588829336908 30.3098862277533 11.9053318737372 1.34818059896066 6.35619138046221e-12 1.9932535448773e-10 UP ENSG00000075651 PLD1 phospholipase D1 [Source:HGNC Symbol;Acc:HGNC:9067] GO:0040011|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0040012|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0045177|GO:0048870|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0016787|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0044255|GO:0006935|GO:0006810|GO:0016324|GO:0060627|GO:0043168|GO:0016788|GO:0044281|GO:0005543|GO:0031982|GO:0019637|GO:0051128|GO:0022607|GO:0043231|GO:0005774|GO:0005737|GO:0006928|GO:0007154|GO:0051270|GO:0006629|GO:0060491|GO:0016477|GO:0007165|GO:0005783|GO:0010008|GO:0030030|GO:2000145|GO:0044249|GO:0005794|GO:0005768|GO:0016192|GO:0006909|GO:0031344|GO:0008654|GO:0046486|GO:0031410|GO:0016042|GO:0035091|GO:0032528|GO:0005773|GO:0030334|GO:0016023|GO:0005770|GO:0030031|GO:0030100|GO:0048471|GO:0031988|GO:0016298|GO:0006796|GO:0035556|GO:0008610|GO:0000139|GO:0032534|GO:0031902|GO:0042578|GO:0006644|GO:0004620|GO:0030033|GO:0008081|GO:0050764|GO:0030139|GO:0000323|GO:0046474|GO:0048017|GO:0006897|GO:0007264|GO:0005765|GO:0006650|GO:0007265|GO:0006654|GO:0006655|GO:0005764|GO:0004630|GO:0046473|GO:0070290 locomotion|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|regulation of locomotion|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|apical part of cell|cell motility|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|hydrolase activity|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|chemotaxis|transport|apical plasma membrane|regulation of vesicle-mediated transport|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|phospholipid binding|vesicle|organophosphate metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|movement of cell or subcellular component|cell communication|regulation of cellular component movement|lipid metabolic process|regulation of cell projection assembly|cell migration|signal transduction|endoplasmic reticulum|endosome membrane|cell projection organization|regulation of cell motility|cellular biosynthetic process|Golgi apparatus|endosome|vesicle-mediated transport|phagocytosis|regulation of cell projection organization|phospholipid biosynthetic process|glycerolipid metabolic process|cytoplasmic vesicle|lipid catabolic process|phosphatidylinositol binding|microvillus organization|vacuole|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|late endosome|cell projection assembly|regulation of endocytosis|perinuclear region of cytoplasm|membrane-bounded vesicle|lipase activity|phosphate-containing compound metabolic process|intracellular signal transduction|lipid biosynthetic process|Golgi membrane|regulation of microvillus assembly|late endosome membrane|phosphoric ester hydrolase activity|phospholipid metabolic process|phospholipase activity|microvillus assembly|phosphoric diester hydrolase activity|regulation of phagocytosis|endocytic vesicle|lytic vacuole|glycerophospholipid biosynthetic process|inositol lipid-mediated signaling|endocytosis|small GTPase mediated signal transduction|lysosomal membrane|glycerophospholipid metabolic process|Ras protein signal transduction|phosphatidic acid biosynthetic process|phosphatidylglycerol biosynthetic process|lysosome|phospholipase D activity|phosphatidic acid metabolic process|N-acylphosphatidylethanolamine-specific phospholipase D activity K01115 phospholipase D1/2[3.1.4.4] hsa01100|hsa05200|hsa04144|hsa04014|hsa04024|hsa04072|hsa04071|hsa04724|hsa05231|hsa00564|hsa04666|hsa04912|hsa05212|hsa00565 Metabolic pathways - Homo sapiens (human)|Pathways in cancer - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Ether lipid metabolism - Homo sapiens (human) 3:171600405-171810950 49 54 120 384 336 670 0.186510451831271 0.186801243664967 0.41181478661991 1.30958963970447 1.04933366728084 2.39006781243827 0.261708827372049 1.58299703980786 -2.59662406559379 6.36612392040773e-12 1.99427348919048e-10 DOWN ENSG00000144583 MARCH4 membrane associated ring-CH-type finger 4 [Source:HGNC Symbol;Acc:HGNC:29269] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0031224|GO:0016874|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0043231|GO:0043169|GO:0005737|GO:0019787|GO:0016021|GO:0019538|GO:0005794|GO:0005802|GO:0046872|GO:0043412|GO:0004842|GO:0036211|GO:0005795|GO:0044267|GO:0000139|GO:0046914|GO:0006464|GO:0008270|GO:0032446|GO:0016567 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|ligase activity|intracellular|endomembrane system|transferase activity|organelle membrane|intracellular membrane-bounded organelle|cation binding|cytoplasm|ubiquitin-like protein transferase activity|integral component of membrane|protein metabolic process|Golgi apparatus|trans-Golgi network|metal ion binding|macromolecule modification|ubiquitin-protein transferase activity|protein modification process|Golgi stack|cellular protein metabolic process|Golgi membrane|transition metal ion binding|cellular protein modification process|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 2:216257865-216372027 30 48 75 280 328 194 0.477192073171542 0.693903867730006 1.07561362204248 3.99056929750513 4.2807608584367 2.89207476692974 0.748903187648009 3.72113497429052 -2.31289158583566 6.42931645744297e-12 2.01195821300317e-10 DOWN ENSG00000066827 ZFAT zinc finger and AT-hook domain containing [Source:HGNC Symbol;Acc:HGNC:19899] GO:0032502|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0002520|GO:0048856|GO:0019222|GO:0001890|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0048608|GO:0043169|GO:0005737|GO:0000981|GO:0048568|GO:0006139|GO:0001892|GO:0048869|GO:0044249|GO:0031323|GO:0000982|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0061458|GO:0030097|GO:0060712|GO:0051252|GO:0009790|GO:0010628|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0009792|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0003690|GO:0002244|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0043009|GO:0000976|GO:0001012|GO:0001701|GO:0000977 developmental process|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|immune system development|anatomical structure development|regulation of metabolic process|placenta development|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|reproductive structure development|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|embryonic organ development|nucleobase-containing compound metabolic process|embryonic placenta development|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|reproductive system development|hemopoiesis|spongiotrophoblast layer development|regulation of RNA metabolic process|embryo development|positive regulation of gene expression|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|hematopoietic progenitor cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 8:134477788-134713049 69 76 110 309 317 323 0.351266481233863 0.351625401799876 0.504885604503582 1.40942858685034 1.32407920255026 1.54105616362132 0.402592495845774 1.42485465100731 -1.82342257150195 6.4623195589519e-12 2.02016846191571e-10 DOWN ENSG00000109066 TMEM104 transmembrane protein 104 [Source:HGNC Symbol;Acc:HGNC:25984] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 17:74776483-74839779 48 74 78 273 328 226 0.290299550565126 0.406742506314222 0.425321012229495 1.47934025638265 1.6276114515619 1.28099199791597 0.374121023036281 1.46264790195351 -1.96700557355778 6.60850731313631e-12 2.06370687579886e-10 DOWN ENSG00000171763 SPATA5L1 spermatogenesis associated 5-like 1 [Source:HGNC Symbol;Acc:HGNC:28762] GO:0005623|GO:0005488|GO:0036094|GO:0097159|GO:0043167|GO:0005622|GO:0043168|GO:0001882|GO:0005737|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005524|GO:0030554 cell|binding|small molecule binding|organic cyclic compound binding|ion binding|intracellular|anion binding|nucleoside binding|cytoplasm|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|ATP binding|adenyl nucleotide binding - - - - 15:45402331-45421419 826 833 677 288 324 200 7.76563525971414 7.11741279981904 5.73852204331983 2.42597612555129 2.49924890330669 1.76220646963759 6.873856700951 2.22914383283186 1.62463006844297 6.69824693556633e-12 2.08954507852035e-10 UP ENSG00000110911 SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:10908] GO:0032502|GO:0032991|GO:0005215|GO:0002376|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0022857|GO:0045178|GO:0051606|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0009986|GO:0044237|GO:0045177|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0019867|GO:0071944|GO:0002262|GO:0030904|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0005903|GO:0006725|GO:0070826|GO:0008565|GO:0048468|GO:0006810|GO:1901360|GO:0010941|GO:0016324|GO:0007275|GO:0048513|GO:0050877|GO:0034101|GO:0016358|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0005887|GO:0043231|GO:0043169|GO:0042168|GO:0005774|GO:0005737|GO:0042592|GO:0031966|GO:0045184|GO:0019725|GO:0051186|GO:0022891|GO:0006979|GO:0048871|GO:0031226|GO:0043085|GO:0008104|GO:0055085|GO:0009593|GO:0008219|GO:0007611|GO:0001666|GO:0010008|GO:0050790|GO:0030030|GO:0031253|GO:0048869|GO:0016021|GO:0010035|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0005768|GO:0032268|GO:0005740|GO:0000902|GO:0031175|GO:0030218|GO:0005802|GO:0046872|GO:0030097|GO:0031410|GO:0051345|GO:0060586|GO:0005769|GO:0005741|GO:0048878|GO:0048813|GO:0031526|GO:0051604|GO:0015031|GO:0000904|GO:0005773|GO:0010038|GO:0006778|GO:0048872|GO:0006811|GO:0008320|GO:0055082|GO:0015075|GO:0055037|GO:0005770|GO:0034599|GO:0006783|GO:0051247|GO:0048471|GO:0006508|GO:0003032|GO:0005739|GO:0032270|GO:0012501|GO:0044267|GO:0010467|GO:0032990|GO:0007399|GO:0050890|GO:0051246|GO:0010039|GO:0030154|GO:0048858|GO:0043068|GO:0031902|GO:0005634|GO:0043067|GO:0034220|GO:0048666|GO:0030182|GO:0033572|GO:0006779|GO:0098655|GO:0043065|GO:0000323|GO:0016485|GO:0015293|GO:0015992|GO:0033014|GO:0030162|GO:0006812|GO:0045862|GO:0052547|GO:0042981|GO:0046914|GO:0050801|GO:0048821|GO:0030099|GO:0022008|GO:0048667|GO:0015450|GO:0048812|GO:0010952|GO:0005765|GO:0006915|GO:0006873|GO:0008324|GO:0046870|GO:0033570|GO:0010950|GO:0005764|GO:0043281|GO:1902600|GO:0048699|GO:0022890|GO:0031638|GO:0030001|GO:0043280|GO:0006919|GO:0030003|GO:0015672|GO:0052548|GO:0071421|GO:0035444|GO:0006824|GO:0015295|GO:2001056|GO:0070574|GO:0055065|GO:0006875|GO:0035434|GO:2000116|GO:0015692|GO:0034755|GO:0015077|GO:0097202|GO:0071577|GO:0046873|GO:0015086|GO:0015091|GO:0015093|GO:0046915|GO:0015684|GO:0015078|GO:1903874|GO:0006829|GO:0015676|GO:0005385|GO:0006828|GO:0006826|GO:0015675|GO:0015094|GO:0006825|GO:0005384|GO:0015100|GO:0005375|GO:0006879|GO:0055072|GO:0097286|GO:0070627|GO:0015639|GO:0015099|GO:0015087|GO:0005381 developmental process|macromolecular complex|transporter activity|immune system process|behavior|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|transmembrane transporter activity|basal part of cell|detection of stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cell surface|cellular metabolic process|apical part of cell|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|outer membrane|cell periphery|myeloid cell homeostasis|retromer complex|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|immune system development|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|brush border|cellular aromatic compound metabolic process|paraferritin complex|protein transporter activity|cell development|transport|organic cyclic compound metabolic process|regulation of cell death|apical plasma membrane|multicellular organism development|animal organ development|neurological system process|erythrocyte homeostasis|dendrite development|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|heme metabolic process|vacuolar membrane|cytoplasm|homeostatic process|mitochondrial membrane|establishment of protein localization|cellular homeostasis|cofactor metabolic process|substrate-specific transmembrane transporter activity|response to oxidative stress|multicellular organismal homeostasis|intrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|transmembrane transport|detection of chemical stimulus|cell death|learning or memory|response to hypoxia|endosome membrane|regulation of catalytic activity|cell projection organization|cell projection membrane|cellular developmental process|integral component of membrane|response to inorganic substance|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|endosome|regulation of cellular protein metabolic process|mitochondrial envelope|cell morphogenesis|neuron projection development|erythrocyte differentiation|trans-Golgi network|metal ion binding|hemopoiesis|cytoplasmic vesicle|positive regulation of hydrolase activity|multicellular organismal iron ion homeostasis|early endosome|mitochondrial outer membrane|chemical homeostasis|dendrite morphogenesis|brush border membrane|protein maturation|protein transport|cell morphogenesis involved in differentiation|vacuole|response to metal ion|porphyrin-containing compound metabolic process|homeostasis of number of cells|ion transport|protein transmembrane transporter activity|cellular chemical homeostasis|ion transmembrane transporter activity|recycling endosome|late endosome|cellular response to oxidative stress|heme biosynthetic process|positive regulation of protein metabolic process|perinuclear region of cytoplasm|proteolysis|detection of oxygen|mitochondrion|positive regulation of cellular protein metabolic process|programmed cell death|cellular protein metabolic process|gene expression|cell part morphogenesis|nervous system development|cognition|regulation of protein metabolic process|response to iron ion|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|late endosome membrane|nucleus|regulation of programmed cell death|ion transmembrane transport|neuron development|neuron differentiation|transferrin transport|porphyrin-containing compound biosynthetic process|cation transmembrane transport|positive regulation of apoptotic process|lytic vacuole|protein processing|symporter activity|proton transport|tetrapyrrole biosynthetic process|regulation of proteolysis|cation transport|positive regulation of proteolysis|regulation of peptidase activity|regulation of apoptotic process|transition metal ion binding|ion homeostasis|erythrocyte development|myeloid cell differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|neuron projection morphogenesis|positive regulation of peptidase activity|lysosomal membrane|apoptotic process|cellular ion homeostasis|cation transmembrane transporter activity|cadmium ion binding|transferrin transmembrane transporter activity|positive regulation of endopeptidase activity|lysosome|regulation of cysteine-type endopeptidase activity involved in apoptotic process|hydrogen ion transmembrane transport|generation of neurons|inorganic cation transmembrane transporter activity|zymogen activation|metal ion transport|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular cation homeostasis|monovalent inorganic cation transport|regulation of endopeptidase activity|manganese ion transmembrane transport|nickel cation transmembrane transport|cobalt ion transport|solute:proton symporter activity|positive regulation of cysteine-type endopeptidase activity|cadmium ion transmembrane transport|metal ion homeostasis|cellular metal ion homeostasis|copper ion transmembrane transport|regulation of cysteine-type endopeptidase activity|lead ion transport|iron ion transmembrane transport|monovalent inorganic cation transmembrane transporter activity|activation of cysteine-type endopeptidase activity|zinc II ion transmembrane transport|metal ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|ferric iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|transition metal ion transmembrane transporter activity|ferrous iron transport|hydrogen ion transmembrane transporter activity|ferrous iron transmembrane transport|zinc II ion transport|vanadium ion transport|zinc ion transmembrane transporter activity|manganese ion transport|iron ion transport|nickel cation transport|lead ion transmembrane transporter activity|copper ion transport|manganese ion transmembrane transporter activity|vanadium ion transmembrane transporter activity|copper ion transmembrane transporter activity|cellular iron ion homeostasis|iron ion homeostasis|iron ion import|ferrous iron import|ferrous iron uptake transmembrane transporter activity|nickel cation transmembrane transporter activity|cobalt ion transmembrane transporter activity|iron ion transmembrane transporter activity K12347 natural resistance-associated macrophage protein[-] hsa04142|hsa04978 Lysosome - Homo sapiens (human)|Mineral absorption - Homo sapiens (human) 12:50979401-51028566 140 136 273 594 733 875 0.556451235566972 0.49126667880842 0.978309508951143 2.11535337889638 2.39040172349651 3.25938587575404 0.675342474442178 2.58838032604898 -1.93835841545974 6.72694030075829e-12 2.09630559226344e-10 DOWN ENSG00000050344 NFE2L3 nuclear factor, erythroid 2 like 3 [Source:HGNC Symbol;Acc:HGNC:7783] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003713|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0010628|GO:0010467|GO:0001227|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0001078|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription coactivator activity|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 7:26152240-26187125 375 459 796 1643 1923 1953 4.25237446827773 4.73034659810048 8.13818442165906 16.6930500786266 17.8915363973139 20.7554264334765 5.70696849601242 18.4466709698057 -1.69256397568306 6.74743930520829e-12 2.09831305226759e-10 DOWN ENSG00000146376 ARHGAP18 Rho GTPase activating protein 18 [Source:HGNC Symbol;Acc:HGNC:21035] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0040012|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0009893|GO:0030234|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0008360|GO:0032535|GO:0008047|GO:0051128|GO:0022607|GO:0005737|GO:0032970|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0051270|GO:0007165|GO:0050790|GO:0048869|GO:0030029|GO:2000145|GO:0043254|GO:0006996|GO:0000902|GO:0005829|GO:0005096|GO:0032956|GO:0007010|GO:0051345|GO:0030695|GO:0022604|GO:0006461|GO:0030036|GO:0035556|GO:0033043|GO:0030832|GO:1902531|GO:0034622|GO:0043623|GO:0043087|GO:0008064|GO:0043547|GO:0051493|GO:0051056|GO:0007264|GO:0007015|GO:0030833|GO:0051258|GO:0008154|GO:0030041 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of locomotion|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|regulation of cell shape|regulation of cellular component size|enzyme activator activity|regulation of cellular component organization|cellular component assembly|cytoplasm|regulation of actin filament-based process|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|signal transduction|regulation of catalytic activity|cellular developmental process|actin filament-based process|regulation of cell motility|regulation of protein complex assembly|organelle organization|cell morphogenesis|cytosol|GTPase activator activity|regulation of actin cytoskeleton organization|cytoskeleton organization|positive regulation of hydrolase activity|GTPase regulator activity|regulation of cell morphogenesis|protein complex assembly|actin cytoskeleton organization|intracellular signal transduction|regulation of organelle organization|regulation of actin filament length|regulation of intracellular signal transduction|cellular macromolecular complex assembly|cellular protein complex assembly|regulation of GTPase activity|regulation of actin polymerization or depolymerization|positive regulation of GTPase activity|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|actin filament organization|regulation of actin filament polymerization|protein polymerization|actin polymerization or depolymerization|actin filament polymerization - - - - 6:129576132-129710225 162 180 200 582 538 627 2.37450627542352 2.39778582143235 2.64303287558517 7.64327351246352 6.47006470937196 8.61300882539556 2.47177499081368 7.57544901574368 -1.61578398460877 6.74454299652555e-12 2.09831305226759e-10 DOWN ENSG00000143919 CAMKMT calmodulin-lysine N-methyltransferase [Source:HGNC Symbol;Acc:HGNC:26276] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0032259|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0012505|GO:0016740|GO:0043231|GO:0005737|GO:0019538|GO:0005794|GO:0008168|GO:0043412|GO:0006479|GO:0036211|GO:0044267|GO:0005634|GO:0018022|GO:0008276|GO:0006464|GO:0008757|GO:0008170|GO:0016279|GO:0018193|GO:0018025|GO:0018205 cell|cellular process|metabolic process|catalytic activity|methylation|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|endomembrane system|transferase activity|intracellular membrane-bounded organelle|cytoplasm|protein metabolic process|Golgi apparatus|methyltransferase activity|macromolecule modification|protein methylation|protein modification process|cellular protein metabolic process|nucleus|peptidyl-lysine methylation|protein methyltransferase activity|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|N-methyltransferase activity|protein-lysine N-methyltransferase activity|peptidyl-amino acid modification|calmodulin-lysine N-methyltransferase activity|peptidyl-lysine modification K18826 calmodulin-lysine N-methyltransferase[2.1.1.60] hsa00310 Lysine degradation - Homo sapiens (human) 2:44361950-44772592 24 16 20 120 115 97 0.315435111799491 0.191117954898757 0.237005024142377 1.41312631734894 1.24012729556928 1.19481475025884 0.247852696946875 1.28268945439235 -2.3716170666026 6.80134822858814e-12 2.11287669111624e-10 DOWN ENSG00000073711 PPP2R3A protein phosphatase 2 regulatory subunit B'', alpha [Source:HGNC Symbol;Acc:HGNC:9307] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0048523|GO:0050794|GO:0040012|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0040008|GO:0023057|GO:0009893|GO:0008287|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0001756|GO:0009888|GO:0007275|GO:0019208|GO:0048513|GO:0061061|GO:0043169|GO:0007389|GO:0007423|GO:0006928|GO:0009887|GO:0009966|GO:0030674|GO:0000159|GO:0010646|GO:0007154|GO:0051270|GO:0007165|GO:0009968|GO:0048638|GO:0050790|GO:0048869|GO:2000145|GO:0009967|GO:0019538|GO:0031323|GO:0060560|GO:0090245|GO:0032268|GO:0030111|GO:0045732|GO:0030178|GO:0046872|GO:0007166|GO:0001654|GO:0043412|GO:0030163|GO:0009790|GO:0090249|GO:0036211|GO:0003002|GO:0051247|GO:0014807|GO:0060429|GO:0006796|GO:0044267|GO:0051174|GO:0042176|GO:0003401|GO:0007399|GO:0019888|GO:0051246|GO:0030177|GO:0030154|GO:0090244|GO:0045995|GO:0007525|GO:0030182|GO:0016055|GO:0016311|GO:0009792|GO:0090090|GO:0060828|GO:0008601|GO:0005509|GO:0061053|GO:0009952|GO:0022008|GO:0006464|GO:0090263|GO:0035282|GO:0048592|GO:0010921|GO:0006470|GO:0035304|GO:0048699|GO:0043666|GO:0060070|GO:0001754|GO:0043009|GO:0035303|GO:0034047 locomotion|developmental process|growth|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|binding, bridging|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|protein serine/threonine phosphatase complex|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|somitogenesis|tissue development|multicellular organism development|phosphatase regulator activity|animal organ development|muscle structure development|cation binding|pattern specification process|sensory organ development|movement of cell or subcellular component|organ morphogenesis|regulation of signal transduction|protein binding, bridging|protein phosphatase type 2A complex|regulation of cell communication|cell communication|regulation of cellular component movement|signal transduction|negative regulation of signal transduction|regulation of developmental growth|regulation of catalytic activity|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|regulation of cellular metabolic process|developmental growth involved in morphogenesis|axis elongation involved in somitogenesis|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|positive regulation of protein catabolic process|negative regulation of Wnt signaling pathway|metal ion binding|cell surface receptor signaling pathway|eye development|macromolecule modification|protein catabolic process|embryo development|regulation of cell motility involved in somitogenic axis elongation|protein modification process|regionalization|positive regulation of protein metabolic process|regulation of somitogenesis|epithelium development|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|axis elongation|nervous system development|protein phosphatase regulator activity|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|cell differentiation|Wnt signaling pathway involved in somitogenesis|regulation of embryonic development|somatic muscle development|neuron differentiation|Wnt signaling pathway|dephosphorylation|embryo development ending in birth or egg hatching|negative regulation of canonical Wnt signaling pathway|regulation of canonical Wnt signaling pathway|protein phosphatase type 2A regulator activity|calcium ion binding|somite development|anterior/posterior pattern specification|neurogenesis|cellular protein modification process|positive regulation of canonical Wnt signaling pathway|segmentation|eye morphogenesis|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|generation of neurons|regulation of phosphoprotein phosphatase activity|canonical Wnt signaling pathway|eye photoreceptor cell differentiation|chordate embryonic development|regulation of dephosphorylation|regulation of protein phosphatase type 2A activity K11583 serine/threonine-protein phosphatase 2A regulatory subunit B''[-] hsa04151|hsa04261|hsa04728|hsa04152|hsa04071|hsa03015 PI3K-Akt signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human) 3:135965673-136147891 109 137 336 769 1051 1042 0.865744755958784 0.988927780090994 2.40611851381831 5.4725174758869 6.84910433641227 7.75639122432985 1.42026368328936 6.69267101220967 -2.2364232958665 6.81379081149726e-12 2.11454169320623e-10 DOWN ENSG00000131471 AOC3 amine oxidase, copper containing 3 [Source:HGNC Symbol;Acc:HGNC:550] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009986|GO:0044237|GO:0007155|GO:0043227|GO:0048037|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0042802|GO:0048038|GO:0009410|GO:0044281|GO:0006952|GO:0043231|GO:0043169|GO:0005737|GO:0046983|GO:0005783|GO:0006805|GO:0016021|GO:0016638|GO:0005794|GO:0005768|GO:0055114|GO:0009636|GO:0016641|GO:0046872|GO:0005769|GO:0046982|GO:0009308|GO:0006954|GO:0071466|GO:0046677|GO:0005902|GO:0042803|GO:0052593|GO:0008131|GO:0052596|GO:0005509|GO:0046914|GO:0052595|GO:0052594|GO:0005507 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cell surface|cellular metabolic process|cell adhesion|membrane-bounded organelle|cofactor binding|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|identical protein binding|quinone binding|response to xenobiotic stimulus|small molecule metabolic process|defense response|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein dimerization activity|endoplasmic reticulum|xenobiotic metabolic process|integral component of membrane|oxidoreductase activity, acting on the CH-NH2 group of donors|Golgi apparatus|endosome|oxidation-reduction process|response to toxic substance|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|metal ion binding|early endosome|protein heterodimerization activity|amine metabolic process|inflammatory response|cellular response to xenobiotic stimulus|response to antibiotic|microvillus|protein homodimerization activity|tryptamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|calcium ion binding|transition metal ion binding|aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding K00276 primary-amine oxidase[1.4.3.21] hsa01100|hsa00260|hsa00350|hsa00410|hsa00360 Metabolic pathways - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human)|Tyrosine metabolism - Homo sapiens (human)|beta-Alanine metabolism - Homo sapiens (human)|Phenylalanine metabolism - Homo sapiens (human) 17:42851184-42858130 151 179 86 3 12 23 1.1582373630763 1.24782666415217 0.59474940089025 0.0206148881711648 0.0755224597991285 0.165341975052995 1.00027114270624 0.0871597743410961 3.5205848517057 6.92247104105075e-12 2.14603790716022e-10 UP ENSG00000171877 FRMD5 FERM domain containing 5 [Source:HGNC Symbol;Acc:HGNC:28214] GO:0005623|GO:0016020|GO:0005488|GO:0019898|GO:0043229|GO:0031224|GO:0005622|GO:0005515|GO:0005737|GO:0008092|GO:0016021|GO:0005856 cell|membrane|binding|extrinsic component of membrane|intracellular organelle|intrinsic component of membrane|intracellular|protein binding|cytoplasm|cytoskeletal protein binding|integral component of membrane|cytoskeleton - - - - 15:43870761-44195252 16 18 24 121 126 80 0.067683486910629 0.0692005404510974 0.0915325020671802 0.458605109046334 0.437317792296736 0.317156696625467 0.0761388431429689 0.404359865989512 -2.4089352574422 7.06168962688855e-12 2.18692616308227e-10 DOWN ENSG00000082196 C1QTNF3 C1q and tumor necrosis factor related protein 3 [Source:HGNC Symbol;Acc:HGNC:14326] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0051050|GO:0006950|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:1903828|GO:0009605|GO:0023057|GO:0009058|GO:0005615|GO:0005515|GO:0043234|GO:0019222|GO:0060341|GO:0001818|GO:0044262|GO:1900181|GO:0046887|GO:0006810|GO:0070165|GO:0044281|GO:0032940|GO:0006952|GO:0031982|GO:0022607|GO:0001817|GO:0001816|GO:0007267|GO:0009611|GO:0032880|GO:0005975|GO:0051222|GO:0042592|GO:0009966|GO:0045184|GO:0009890|GO:0046883|GO:0019725|GO:0001819|GO:0032387|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0051649|GO:0090317|GO:0051047|GO:0051048|GO:1903531|GO:0010817|GO:0048869|GO:0044249|GO:0005581|GO:0051224|GO:0031324|GO:0031323|GO:0006109|GO:0010468|GO:0042308|GO:0032715|GO:0032675|GO:0072594|GO:0032635|GO:0010629|GO:0050727|GO:0032642|GO:0048878|GO:0032386|GO:0050709|GO:0050710|GO:0051223|GO:0015031|GO:0070201|GO:0046907|GO:0042886|GO:0006954|GO:0055082|GO:0050714|GO:0032602|GO:0050715|GO:0051046|GO:0050728|GO:0009914|GO:0009306|GO:0005996|GO:0006461|GO:0034613|GO:0050663|GO:0035556|GO:0010467|GO:0017038|GO:0031503|GO:0046903|GO:1902532|GO:0030154|GO:0050707|GO:1903827|GO:1902531|GO:0016051|GO:0006606|GO:0032682|GO:1904589|GO:0019318|GO:0043124|GO:0045444|GO:0033365|GO:0033157|GO:0043122|GO:0051169|GO:0051259|GO:0071638|GO:0035356|GO:0050708|GO:0006111|GO:0015833|GO:0006605|GO:0016482|GO:0006886|GO:0010906|GO:0007249|GO:1900165|GO:0042992|GO:0055088|GO:0042306|GO:0042345|GO:1900180|GO:0045721|GO:0042991|GO:0046879|GO:1903533|GO:0019319|GO:0006913|GO:0006006|GO:0055090|GO:0070206|GO:0042990|GO:0042347|GO:0034504|GO:0046822|GO:0051170|GO:0070328|GO:0006094 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|positive regulation of transport|response to stress|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of cellular protein localization|response to external stimulus|negative regulation of signaling|biosynthetic process|extracellular space|protein binding|protein complex|regulation of metabolic process|regulation of cellular localization|negative regulation of cytokine production|cellular carbohydrate metabolic process|negative regulation of protein localization to nucleus|positive regulation of hormone secretion|transport|positive regulation of adiponectin secretion|small molecule metabolic process|secretion by cell|defense response|vesicle|cellular component assembly|regulation of cytokine production|cytokine production|cell-cell signaling|response to wounding|regulation of protein localization|carbohydrate metabolic process|positive regulation of protein transport|homeostatic process|regulation of signal transduction|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|cellular homeostasis|positive regulation of cytokine production|negative regulation of intracellular transport|regulation of cell communication|protein localization|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|negative regulation of intracellular protein transport|positive regulation of secretion|negative regulation of secretion|negative regulation of secretion by cell|regulation of hormone levels|cellular developmental process|cellular biosynthetic process|collagen trimer|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of carbohydrate metabolic process|regulation of gene expression|negative regulation of protein import into nucleus|negative regulation of interleukin-6 production|regulation of interleukin-6 production|establishment of protein localization to organelle|interleukin-6 production|negative regulation of gene expression|regulation of inflammatory response|regulation of chemokine production|chemical homeostasis|regulation of intracellular transport|negative regulation of protein secretion|negative regulation of cytokine secretion|regulation of protein transport|protein transport|regulation of establishment of protein localization|intracellular transport|amide transport|inflammatory response|cellular chemical homeostasis|positive regulation of protein secretion|chemokine production|positive regulation of cytokine secretion|regulation of secretion|negative regulation of inflammatory response|hormone transport|protein secretion|monosaccharide metabolic process|protein complex assembly|cellular protein localization|cytokine secretion|intracellular signal transduction|gene expression|protein import|protein complex localization|secretion|negative regulation of intracellular signal transduction|cell differentiation|regulation of cytokine secretion|regulation of cellular protein localization|regulation of intracellular signal transduction|carbohydrate biosynthetic process|protein import into nucleus|negative regulation of chemokine production|regulation of protein import|hexose metabolic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|fat cell differentiation|protein localization to organelle|regulation of intracellular protein transport|regulation of I-kappaB kinase/NF-kappaB signaling|nuclear transport|protein oligomerization|negative regulation of monocyte chemotactic protein-1 production|cellular triglyceride homeostasis|regulation of protein secretion|regulation of gluconeogenesis|peptide transport|protein targeting|cytosolic transport|intracellular protein transport|regulation of glucose metabolic process|I-kappaB kinase/NF-kappaB signaling|negative regulation of interleukin-6 secretion|negative regulation of transcription factor import into nucleus|lipid homeostasis|regulation of protein import into nucleus|regulation of NF-kappaB import into nucleus|regulation of protein localization to nucleus|negative regulation of gluconeogenesis|transcription factor import into nucleus|hormone secretion|regulation of protein targeting|hexose biosynthetic process|nucleocytoplasmic transport|glucose metabolic process|acylglycerol homeostasis|protein trimerization|regulation of transcription factor import into nucleus|negative regulation of NF-kappaB import into nucleus|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import|triglyceride homeostasis|gluconeogenesis - - - - 5:34019448-34043832 1 1 7 39 36 63 0.00899309866852381 0.00817355785194299 0.0567305870885914 0.31411323857523 0.265516107695229 0.530753027836962 0.0246324145363527 0.370127458035807 -3.90939220967016 8.10224021744663e-12 2.50657284405857e-10 DOWN ENSG00000174501 ANKRD36C ankyrin repeat domain 36C [Source:HGNC Symbol;Acc:HGNC:32946] GO:0005488|GO:0016247|GO:0005515|GO:0016248|GO:0008200 binding|channel regulator activity|protein binding|channel inhibitor activity|ion channel inhibitor activity - - - - 2:95836919-95991831 7 8 31 117 138 248 0.0514567256688771 0.0534447071217454 0.205454248957835 0.770584572509353 0.832301582220164 1.70850149012114 0.103451893916153 1.10379588161689 -3.41544144551751 8.77647926281553e-12 2.71235001979394e-10 DOWN ENSG00000134146 DPH6 diphthamine biosynthesis 6 [Source:HGNC Symbol;Acc:HGNC:30543] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:1903829|GO:0060341|GO:0006810|GO:0051130|GO:0043168|GO:0001882|GO:0051128|GO:0043231|GO:0005737|GO:0032880|GO:0051222|GO:0045184|GO:0032388|GO:0008104|GO:0031647|GO:0051649|GO:0090316|GO:0000166|GO:0017183|GO:0044249|GO:0019538|GO:0006996|GO:0005730|GO:0005829|GO:0035639|GO:0043412|GO:0072594|GO:0007005|GO:0032386|GO:0001883|GO:0051223|GO:1903955|GO:0015031|GO:0016881|GO:0036211|GO:0070201|GO:0046907|GO:0032549|GO:0031981|GO:0034613|GO:0033043|GO:0044267|GO:0017076|GO:0006626|GO:1903827|GO:0005634|GO:0010638|GO:0017178|GO:0033365|GO:0033157|GO:0005524|GO:0006839|GO:0030554|GO:0006605|GO:0072655|GO:0010822|GO:0016482|GO:0006886|GO:0010821|GO:0006464|GO:1903214|GO:1903533|GO:0018193|GO:0043687|GO:0070585 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|positive regulation of cellular protein localization|regulation of cellular localization|transport|positive regulation of cellular component organization|anion binding|nucleoside binding|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|positive regulation of intracellular transport|protein localization|regulation of protein stability|establishment of localization in cell|positive regulation of intracellular protein transport|nucleotide binding|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|cellular biosynthetic process|protein metabolic process|organelle organization|nucleolus|cytosol|purine ribonucleoside triphosphate binding|macromolecule modification|establishment of protein localization to organelle|mitochondrion organization|regulation of intracellular transport|purine nucleoside binding|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|acid-amino acid ligase activity|protein modification process|regulation of establishment of protein localization|intracellular transport|ribonucleoside binding|nuclear lumen|cellular protein localization|regulation of organelle organization|cellular protein metabolic process|purine nucleotide binding|protein targeting to mitochondrion|regulation of cellular protein localization|nucleus|positive regulation of organelle organization|diphthine-ammonia ligase activity|protein localization to organelle|regulation of intracellular protein transport|ATP binding|mitochondrial transport|adenyl nucleotide binding|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|cellular protein modification process|regulation of protein targeting to mitochondrion|regulation of protein targeting|peptidyl-amino acid modification|post-translational protein modification|protein localization to mitochondrion - - - - 15:35217345-35546193 13 14 22 85 136 82 0.0907499702753967 0.0888209048758485 0.138463475335435 0.531650269027024 0.778956853043015 0.536478465259736 0.106011450162227 0.615695195776592 -2.53799621449064 8.94743368862981e-12 2.76060847342038e-10 DOWN ENSG00000213676 ATF6B activating transcription factor 6 beta [Source:HGNC Symbol;Acc:HGNC:2349] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0032993|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0031227|GO:0005737|GO:0006139|GO:0030176|GO:0007154|GO:0007165|GO:0005783|GO:0016021|GO:0044249|GO:0031301|GO:0010033|GO:0031323|GO:0005794|GO:0003677|GO:0010468|GO:0034645|GO:0030968|GO:0043620|GO:0006984|GO:0051252|GO:0010628|GO:0006986|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0035967|GO:0016070|GO:0034976|GO:0010557|GO:0005634|GO:0034620|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0036500|GO:1990440|GO:0006351|GO:0006355|GO:0043618|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0036003|GO:0035497 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|protein-DNA complex|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cytoplasm|nucleobase-containing compound metabolic process|integral component of endoplasmic reticulum membrane|cell communication|signal transduction|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|integral component of organelle membrane|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|endoplasmic reticulum unfolded protein response|regulation of DNA-templated transcription in response to stress|ER-nucleus signaling pathway|regulation of RNA metabolic process|positive regulation of gene expression|response to unfolded protein|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cellular response to topologically incorrect protein|RNA metabolic process|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to unfolded protein|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|ATF6-mediated unfolded protein response|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter in response to stress|cAMP response element binding K09049 cyclic AMP-dependent transcription factor ATF-6 beta[-] hsa04151|hsa05203|hsa05034|hsa04141|hsa04022|hsa04261|hsa05161|hsa04728|hsa04668|hsa04915|hsa04211|hsa04911|hsa04925|hsa04918|hsa05031|hsa05030 PI3K-Akt signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human) 6:32098176-32128253 430 491 654 1450 1553 1467 5.4286674188181 5.63360623692325 7.44418669144937 16.4017773702895 16.0866055924887 17.3573778095542 6.16882011573024 16.6152535907775 -1.42944182970977 8.95112548492976e-12 2.76060847342038e-10 DOWN ENSG00000112769 LAMA4 laminin subunit alpha 4 [Source:HGNC Symbol;Acc:HGNC:6484] GO:0040011|GO:0032502|GO:0031012|GO:0005198|GO:0009987|GO:0005576|GO:0005488|GO:0005604|GO:1903561|GO:0005201|GO:0050794|GO:0040012|GO:0005578|GO:0048870|GO:0016043|GO:0007155|GO:0043227|GO:0050793|GO:0005515|GO:0005605|GO:0048856|GO:0001568|GO:0007275|GO:0005102|GO:0043062|GO:0030155|GO:0031982|GO:0006928|GO:0051270|GO:0016477|GO:0070062|GO:0048869|GO:2000145|GO:0001944|GO:0072358|GO:0009790|GO:0030334|GO:0030198|GO:0030154|GO:0072359|GO:0045995|GO:0045444|GO:0050873 locomotion|developmental process|extracellular matrix|structural molecule activity|cellular process|extracellular region|binding|basement membrane|extracellular vesicle|extracellular matrix structural constituent|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|cell motility|cellular component organization|cell adhesion|membrane-bounded organelle|regulation of developmental process|protein binding|basal lamina|anatomical structure development|blood vessel development|multicellular organism development|receptor binding|extracellular structure organization|regulation of cell adhesion|vesicle|movement of cell or subcellular component|regulation of cellular component movement|cell migration|extracellular exosome|cellular developmental process|regulation of cell motility|vasculature development|cardiovascular system development|embryo development|regulation of cell migration|extracellular matrix organization|cell differentiation|circulatory system development|regulation of embryonic development|fat cell differentiation|brown fat cell differentiation K06241 laminin, alpha 4[-] hsa05200|hsa04151|hsa04510|hsa05145|hsa05146|hsa05222|hsa04512|hsa05143 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|African trypanosomiasis - Homo sapiens (human) 6:112108760-112254939 131 144 281 684 726 666 0.478346450669908 0.477873812687694 0.925108339189407 2.23781893785866 2.17508317386041 2.27915946958714 0.627109534182336 2.23068719376874 -1.8306988619035 9.00002454545792e-12 2.77282489969144e-10 DOWN ENSG00000170835 CEL carboxyl ester lipase [Source:HGNC Symbol;Acc:HGNC:1848] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0044877|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0042445|GO:0043227|GO:0008289|GO:0016787|GO:0005615|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0044255|GO:0034641|GO:0016788|GO:0044281|GO:0031982|GO:0030141|GO:0043231|GO:0005737|GO:0032403|GO:0006629|GO:0005783|GO:0051861|GO:0046625|GO:0010817|GO:0098857|GO:0005794|GO:0005829|GO:0006665|GO:0031410|GO:0016042|GO:0006720|GO:0006066|GO:0044242|GO:0006643|GO:0016023|GO:0042572|GO:0042588|GO:0005791|GO:0031988|GO:0016298|GO:0043603|GO:0043208|GO:0045121|GO:0052689|GO:0004620|GO:0006672|GO:0004622|GO:0050253|GO:0004806|GO:0030149|GO:0046466|GO:0004771|GO:0016101|GO:0046514|GO:0001523 macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|lipid binding|hydrolase activity|extracellular space|intracellular|protein binding|protein complex|endomembrane system|cellular lipid metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|secretory granule|intracellular membrane-bounded organelle|cytoplasm|protein complex binding|lipid metabolic process|endoplasmic reticulum|glycolipid binding|sphingolipid binding|regulation of hormone levels|membrane microdomain|Golgi apparatus|cytosol|sphingolipid metabolic process|cytoplasmic vesicle|lipid catabolic process|isoprenoid metabolic process|alcohol metabolic process|cellular lipid catabolic process|membrane lipid metabolic process|cytoplasmic, membrane-bounded vesicle|retinol metabolic process|zymogen granule|rough endoplasmic reticulum|membrane-bounded vesicle|lipase activity|cellular amide metabolic process|glycosphingolipid binding|membrane raft|carboxylic ester hydrolase activity|phospholipase activity|ceramide metabolic process|lysophospholipase activity|retinyl-palmitate esterase activity|triglyceride lipase activity|sphingolipid catabolic process|membrane lipid catabolic process|sterol esterase activity|diterpenoid metabolic process|ceramide catabolic process|retinoid metabolic process K12298 bile salt-stimulated lipase[3.1.1.13] hsa01100|hsa04972|hsa00561|hsa04975|hsa00100 Metabolic pathways - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human)|Fat digestion and absorption - Homo sapiens (human)|Steroid biosynthesis - Homo sapiens (human) 9:133061978-133087355 93 65 57 5 6 15 2.18700782195791 1.3891971608369 1.20852687542622 0.105343152901646 0.115759641442591 0.330594153645803 1.59491061940701 0.183898982663347 3.11649017215862 9.18344687443356e-12 2.82641879370453e-10 UP ENSG00000074527 NTN4 netrin 4 [Source:HGNC Symbol;Acc:HGNC:13658] GO:0040011|GO:0032502|GO:0031012|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0005604|GO:0050840|GO:0005578|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0006935|GO:0009888|GO:0048468|GO:0007275|GO:0048513|GO:0043062|GO:0001763|GO:0006928|GO:0009887|GO:0048729|GO:0007154|GO:0043236|GO:0035426|GO:0060688|GO:0030030|GO:0048869|GO:0048732|GO:0000902|GO:0031175|GO:0060668|GO:0043237|GO:0002009|GO:0060693|GO:0061138|GO:0022612|GO:0000904|GO:2000027|GO:0007431|GO:0035272|GO:0060429|GO:0032990|GO:0007399|GO:0097485|GO:0030198|GO:0030154|GO:0048858|GO:0048469|GO:0048666|GO:0030182|GO:0007411|GO:0042551|GO:0061564|GO:0060445|GO:0007435|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699|GO:0016322 locomotion|developmental process|extracellular matrix|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|basement membrane|extracellular matrix binding|proteinaceous extracellular matrix|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|chemotaxis|tissue development|cell development|multicellular organism development|animal organ development|extracellular structure organization|morphogenesis of a branching structure|movement of cell or subcellular component|organ morphogenesis|tissue morphogenesis|cell communication|laminin binding|extracellular matrix-cell signaling|regulation of morphogenesis of a branching structure|cell projection organization|cellular developmental process|gland development|cell morphogenesis|neuron projection development|regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling|laminin-1 binding|morphogenesis of an epithelium|regulation of branching involved in salivary gland morphogenesis|morphogenesis of a branching epithelium|gland morphogenesis|cell morphogenesis involved in differentiation|regulation of organ morphogenesis|salivary gland development|exocrine system development|epithelium development|cell part morphogenesis|nervous system development|neuron projection guidance|extracellular matrix organization|cell differentiation|cell projection morphogenesis|cell maturation|neuron development|neuron differentiation|axon guidance|neuron maturation|axon development|branching involved in salivary gland morphogenesis|salivary gland morphogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons|neuron remodeling K06845 netrin 4[-] hsa04360 Axon guidance - Homo sapiens (human) 12:95657807-95791152 282 228 382 880 917 1074 4.18017443517752 3.07156430721455 5.10532588590966 11.6876133415476 11.1527706961489 14.9203365806727 4.11902154276724 12.5869068727897 -1.61155021962423 9.34653389070219e-12 2.87365008005173e-10 DOWN ENSG00000144724 PTPRG protein tyrosine phosphatase, receptor type, G [Source:HGNC Symbol;Acc:HGNC:9671] GO:0040011|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0040013|GO:0004872|GO:0048523|GO:0050794|GO:0040012|GO:0071704|GO:0044237|GO:0038023|GO:0048870|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005515|GO:0005886|GO:0042802|GO:0010632|GO:0016788|GO:0031982|GO:0005887|GO:0004888|GO:0006928|GO:0031226|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0070062|GO:0051271|GO:0016021|GO:2000145|GO:0010633|GO:0019538|GO:2000146|GO:0090132|GO:0007166|GO:0043412|GO:0030334|GO:0001667|GO:0036211|GO:0030336|GO:0006796|GO:0044267|GO:0042578|GO:0016311|GO:0007167|GO:0010631|GO:0016791|GO:0006464|GO:0005001|GO:0006470|GO:0004721|GO:0007169|GO:0035335|GO:0004725 locomotion|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|receptor activity|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|organic substance metabolic process|cellular metabolic process|signaling receptor activity|cell motility|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|protein binding|plasma membrane|identical protein binding|regulation of epithelial cell migration|hydrolase activity, acting on ester bonds|vesicle|integral component of plasma membrane|transmembrane signaling receptor activity|movement of cell or subcellular component|intrinsic component of plasma membrane|cell communication|regulation of cellular component movement|cell migration|signal transduction|extracellular exosome|negative regulation of cellular component movement|integral component of membrane|regulation of cell motility|negative regulation of epithelial cell migration|protein metabolic process|negative regulation of cell motility|epithelium migration|cell surface receptor signaling pathway|macromolecule modification|regulation of cell migration|ameboidal-type cell migration|protein modification process|negative regulation of cell migration|phosphate-containing compound metabolic process|cellular protein metabolic process|phosphoric ester hydrolase activity|dephosphorylation|enzyme linked receptor protein signaling pathway|epithelial cell migration|phosphatase activity|cellular protein modification process|transmembrane receptor protein tyrosine phosphatase activity|protein dephosphorylation|phosphoprotein phosphatase activity|transmembrane receptor protein tyrosine kinase signaling pathway|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity - - - - 3:61561569-62297613 3 4 6 31 64 56 0.0114030635782798 0.013816312503561 0.0205603004502623 0.105561479340953 0.199571199636172 0.199467835719161 0.0152598921773677 0.168200171565429 -3.46236250355954 9.36166664791837e-12 2.8753415237341e-10 DOWN ENSG00000067057 PFKP phosphofructokinase, platelet [Source:HGNC Symbol;Acc:HGNC:8878] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0044877|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0031982|GO:0019637|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0032403|GO:0051186|GO:0006139|GO:0055086|GO:0000422|GO:0070062|GO:0016236|GO:0000166|GO:0006091|GO:0006996|GO:0055114|GO:0005829|GO:1903008|GO:0046872|GO:0035639|GO:0000423|GO:0019693|GO:0007005|GO:0006002|GO:0001883|GO:0009116|GO:0032549|GO:0005996|GO:0016052|GO:0016301|GO:0006796|GO:0017076|GO:0016773|GO:0005634|GO:0006757|GO:0019318|GO:0009259|GO:0009117|GO:0019200|GO:0005524|GO:0030554|GO:0016310|GO:0009132|GO:0061621|GO:0006163|GO:0019752|GO:0006096|GO:0008443|GO:0098779|GO:0042278|GO:0046939|GO:0006006|GO:0003872|GO:0061615|GO:0032787|GO:0006165|GO:0006007|GO:0046034|GO:0019674|GO:0046031|GO:0006090|GO:0006734 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|protein complex binding|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|mitophagy|extracellular exosome|macroautophagy|nucleotide binding|generation of precursor metabolites and energy|organelle organization|oxidation-reduction process|cytosol|organelle disassembly|metal ion binding|purine ribonucleoside triphosphate binding|macromitophagy|ribose phosphate metabolic process|mitochondrion organization|fructose 6-phosphate metabolic process|purine nucleoside binding|nucleoside metabolic process|ribonucleoside binding|monosaccharide metabolic process|carbohydrate catabolic process|kinase activity|phosphate-containing compound metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|ATP generation from ADP|hexose metabolic process|ribonucleotide metabolic process|nucleotide metabolic process|carbohydrate kinase activity|ATP binding|adenyl nucleotide binding|phosphorylation|nucleoside diphosphate metabolic process|canonical glycolysis|purine nucleotide metabolic process|carboxylic acid metabolic process|glycolytic process|phosphofructokinase activity|mitophagy in response to mitochondrial depolarization|purine nucleoside metabolic process|nucleotide phosphorylation|glucose metabolic process|6-phosphofructokinase activity|glycolytic process through fructose-6-phosphate|monocarboxylic acid metabolic process|nucleoside diphosphate phosphorylation|glucose catabolic process|ATP metabolic process|NAD metabolic process|ADP metabolic process|pyruvate metabolic process|NADH metabolic process K00850 6-phosphofructokinase 1[2.7.1.11] hsa01100|hsa04152|hsa04919|hsa01200|hsa03018|hsa01230|hsa05230|hsa00010|hsa00051|hsa00052|hsa00030 Metabolic pathways - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|RNA degradation - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human)|Fructose and mannose metabolism - Homo sapiens (human)|Galactose metabolism - Homo sapiens (human)|Pentose phosphate pathway - Homo sapiens (human) 10:3066333-3137712 480 472 1083 2399 2726 2594 5.08212849541877 4.54178527625154 10.3382519804021 22.757905703628 23.68089594521 25.7396799334566 6.6540552506908 24.0594938607649 -1.85430054234897 9.45117642755225e-12 2.89985016514023e-10 DOWN ENSG00000076826 CAMSAP3 calmodulin regulated spectrin associated protein family member 3 [Source:HGNC Symbol;Acc:HGNC:29307] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0005911|GO:0016043|GO:0007155|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0016337|GO:0048468|GO:0007275|GO:0005912|GO:0051128|GO:0098609|GO:0005737|GO:0032886|GO:0032403|GO:0005516|GO:0044092|GO:0005913|GO:0008092|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0043954|GO:0007017|GO:0019538|GO:0031324|GO:0031323|GO:0043296|GO:0006996|GO:0015631|GO:0032268|GO:0031175|GO:0005813|GO:0045216|GO:0043412|GO:0007010|GO:0070507|GO:0005815|GO:0008017|GO:0036211|GO:0032269|GO:0051346|GO:0090136|GO:0006796|GO:0033043|GO:0044267|GO:0051174|GO:0007399|GO:0051246|GO:0030154|GO:0005915|GO:0000226|GO:0005856|GO:0030507|GO:0048666|GO:0030182|GO:0034453|GO:0010923|GO:0016311|GO:0051493|GO:0015630|GO:0045217|GO:0022008|GO:0006464|GO:0051011|GO:0010921|GO:0006470|GO:0035304|GO:0048699|GO:0035305|GO:0045218|GO:0035303|GO:0035308 developmental process|cell|cellular process|metabolic process|cell junction|binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cell-cell junction|cellular component organization|cell adhesion|intracellular|protein binding|anatomical structure development|regulation of metabolic process|single organismal cell-cell adhesion|cell development|multicellular organism development|adherens junction|regulation of cellular component organization|cell-cell adhesion|cytoplasm|regulation of microtubule-based process|protein complex binding|calmodulin binding|negative regulation of molecular function|cell-cell adherens junction|cytoskeletal protein binding|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|cellular component maintenance|microtubule-based process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|apical junction complex|organelle organization|tubulin binding|regulation of cellular protein metabolic process|neuron projection development|centrosome|cell-cell junction organization|macromolecule modification|cytoskeleton organization|regulation of microtubule cytoskeleton organization|microtubule organizing center|microtubule binding|protein modification process|negative regulation of cellular protein metabolic process|negative regulation of hydrolase activity|epithelial cell-cell adhesion|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|regulation of protein metabolic process|cell differentiation|zonula adherens|microtubule cytoskeleton organization|cytoskeleton|spectrin binding|neuron development|neuron differentiation|microtubule anchoring|negative regulation of phosphatase activity|dephosphorylation|regulation of cytoskeleton organization|microtubule cytoskeleton|cell-cell junction maintenance|neurogenesis|cellular protein modification process|microtubule minus-end binding|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|generation of neurons|negative regulation of dephosphorylation|zonula adherens maintenance|regulation of dephosphorylation|negative regulation of protein dephosphorylation - - - - 19:7595902-7618304 1115 1236 1416 460 540 598 14.2496115934721 14.3557772481231 16.3156974588917 5.26725030279373 5.66225846815698 7.16239971547497 14.9736954334956 6.03063616214189 1.3120482124409 9.55321521273224e-12 2.92814873676497e-10 UP ENSG00000179776 CDH5 cadherin 5, type 2 (vascular endothelium) [Source:HGNC Symbol;Acc:HGNC:1764] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043167|GO:0009986|GO:0005911|GO:0016043|GO:0007155|GO:0071944|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0042127|GO:0016337|GO:0045595|GO:0009897|GO:0009888|GO:0008013|GO:0048468|GO:0044325|GO:0001568|GO:0007275|GO:0005102|GO:0005912|GO:0022607|GO:0098609|GO:0045597|GO:0043169|GO:0019899|GO:0071559|GO:0007163|GO:0007154|GO:0007165|GO:0008285|GO:0048869|GO:0016021|GO:0032878|GO:0010033|GO:0043296|GO:0098742|GO:0045216|GO:2000114|GO:0046872|GO:0001955|GO:0007166|GO:0001944|GO:0072358|GO:0010720|GO:0002064|GO:0071560|GO:0030856|GO:0034329|GO:0019902|GO:0030010|GO:0070848|GO:0030858|GO:0060429|GO:0071310|GO:0030154|GO:0005923|GO:0072359|GO:0003158|GO:0001885|GO:0030855|GO:0034332|GO:0071363|GO:0005509|GO:0007179|GO:0019903|GO:0007167|GO:0007156|GO:0045603|GO:0045601|GO:0007043|GO:0061028|GO:0045446|GO:1903140|GO:0007178|GO:1903142|GO:0007169|GO:0048010 developmental process|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|ion binding|cell surface|cell-cell junction|cellular component organization|cell adhesion|cell periphery|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|regulation of cell proliferation|single organismal cell-cell adhesion|regulation of cell differentiation|external side of plasma membrane|tissue development|beta-catenin binding|cell development|ion channel binding|blood vessel development|multicellular organism development|receptor binding|adherens junction|cellular component assembly|cell-cell adhesion|positive regulation of cell differentiation|cation binding|enzyme binding|response to transforming growth factor beta|establishment or maintenance of cell polarity|cell communication|signal transduction|negative regulation of cell proliferation|cellular developmental process|integral component of membrane|regulation of establishment or maintenance of cell polarity|response to organic substance|apical junction complex|cell-cell adhesion via plasma-membrane adhesion molecules|cell-cell junction organization|regulation of establishment of cell polarity|metal ion binding|blood vessel maturation|cell surface receptor signaling pathway|vasculature development|cardiovascular system development|positive regulation of cell development|epithelial cell development|cellular response to transforming growth factor beta stimulus|regulation of epithelial cell differentiation|cell junction assembly|phosphatase binding|establishment of cell polarity|response to growth factor|positive regulation of epithelial cell differentiation|epithelium development|cellular response to organic substance|cell differentiation|bicellular tight junction|circulatory system development|endothelium development|endothelial cell development|epithelial cell differentiation|adherens junction organization|cellular response to growth factor stimulus|calcium ion binding|transforming growth factor beta receptor signaling pathway|protein phosphatase binding|enzyme linked receptor protein signaling pathway|homophilic cell adhesion via plasma membrane adhesion molecules|positive regulation of endothelial cell differentiation|regulation of endothelial cell differentiation|cell-cell junction assembly|establishment of endothelial barrier|endothelial cell differentiation|regulation of establishment of endothelial barrier|transmembrane receptor protein serine/threonine kinase signaling pathway|positive regulation of establishment of endothelial barrier|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway K06533 cadherin 5, type 2, VE-cadherin[-] hsa04514|hsa04670 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human) 16:66366622-66404786 249 266 372 97 111 84 1.59658134843676 1.55007454251563 2.1505470093903 0.557262353981219 0.583958342740602 0.504777717479364 1.76573430011423 0.548666138067062 1.68626782384282 9.68465124701474e-12 2.96539054695772e-10 UP ENSG00000067221 STOML1 stomatin like 1 [Source:HGNC Symbol;Acc:HGNC:14560] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 15:73978923-73994622 10 15 15 69 81 80 0.042105817577335 0.0574046047886131 0.0569460923729885 0.260320169911392 0.27984327561878 0.315702975234899 0.0521521715796455 0.28528880692169 -2.45162391313071 9.88651615193057e-12 3.02112197178656e-10 DOWN ENSG00000145375 SPATA5 spermatogenesis associated 5 [Source:HGNC Symbol;Acc:HGNC:18119] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0044702|GO:0043167|GO:0019953|GO:0043227|GO:0032504|GO:0005622|GO:0048856|GO:0048609|GO:0007275|GO:0043168|GO:0001882|GO:0043231|GO:0005737|GO:0007276|GO:0000166|GO:0048869|GO:0048232|GO:0035639|GO:0001883|GO:0032549|GO:0005739|GO:0017076|GO:0030154|GO:0007283|GO:0005524|GO:0030554 developmental process|reproduction|cell|cellular process|reproductive process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|single organism reproductive process|ion binding|sexual reproduction|membrane-bounded organelle|multicellular organism reproduction|intracellular|anatomical structure development|multicellular organismal reproductive process|multicellular organism development|anion binding|nucleoside binding|intracellular membrane-bounded organelle|cytoplasm|gamete generation|nucleotide binding|cellular developmental process|male gamete generation|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|mitochondrion|purine nucleotide binding|cell differentiation|spermatogenesis|ATP binding|adenyl nucleotide binding K14575 AAA family ATPase[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 4:122923074-123319450 15 29 43 171 167 132 0.125536745704795 0.220582369255902 0.324462389177482 1.28227320700455 1.14675511943489 1.03535809960544 0.22352716804606 1.15479547534829 -2.36911526410523 9.88690348507895e-12 3.02112197178656e-10 DOWN ENSG00000230551 CTB-89H12.4 - - - - - - - 5:149494314-149504670 254 362 473 974 1154 1227 2.08049865460509 2.69477352963628 3.49308140208169 7.14808923764145 7.7554446735264 9.41904058676104 2.75611786210769 8.10752483264296 -1.55662395303547 9.97170406477989e-12 3.04391874386441e-10 DOWN ENSG00000065000 AP3D1 adaptor related protein complex 3, delta 1 subunit [Source:HGNC Symbol;Acc:HGNC:568] GO:0032502|GO:0032991|GO:0005215|GO:0002376|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0045321|GO:0019882|GO:0043229|GO:0051641|GO:0016043|GO:0043473|GO:0007155|GO:0043227|GO:0009605|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:1903706|GO:0016337|GO:0045595|GO:0051640|GO:0008565|GO:0019884|GO:0050867|GO:0006810|GO:0043195|GO:0007275|GO:0048513|GO:0070489|GO:0030155|GO:0048066|GO:0030117|GO:0098609|GO:0045597|GO:0043231|GO:0005774|GO:0005737|GO:0043482|GO:0006928|GO:0042592|GO:0051656|GO:0002696|GO:0001775|GO:0043005|GO:0045184|GO:0019725|GO:0033059|GO:0008104|GO:0046649|GO:0050865|GO:0061024|GO:0010970|GO:0051649|GO:0045785|GO:2000021|GO:0044306|GO:0061088|GO:0010008|GO:0051238|GO:0048869|GO:0007017|GO:0010256|GO:0005794|GO:0005768|GO:0006996|GO:0016192|GO:0051650|GO:0051249|GO:0048069|GO:0016050|GO:0030424|GO:0030097|GO:0030098|GO:0048499|GO:0048878|GO:0034109|GO:0015031|GO:0048489|GO:0005773|GO:0046907|GO:0055082|GO:0051251|GO:0043679|GO:0022407|GO:0008088|GO:0048753|GO:0072657|GO:0031981|GO:0007018|GO:0007159|GO:0005654|GO:0034613|GO:0042110|GO:0050931|GO:0032119|GO:0000139|GO:0051648|GO:0030154|GO:0022409|GO:0072384|GO:0005634|GO:0048007|GO:0048757|GO:0002521|GO:0033365|GO:0050863|GO:0032438|GO:0000323|GO:0047496|GO:0006726|GO:0030217|GO:0008089|GO:0045619|GO:0034112|GO:0070486|GO:0046631|GO:0016482|GO:0006886|GO:0016197|GO:0050801|GO:0050870|GO:0030705|GO:0045621|GO:0005765|GO:0006873|GO:1903039|GO:0045582|GO:0005764|GO:0046632|GO:0045580|GO:0048490|GO:0035646|GO:0071593|GO:0030003|GO:0046638|GO:0055065|GO:0006875|GO:0001865|GO:0006882|GO:0055069|GO:0051138 developmental process|macromolecular complex|transporter activity|immune system process|synapse|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|leukocyte activation|antigen processing and presentation|intracellular organelle|cellular localization|cellular component organization|pigmentation|cell adhesion|membrane-bounded organelle|response to external stimulus|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of cell differentiation|organelle localization|protein transporter activity|antigen processing and presentation of exogenous antigen|positive regulation of cell activation|transport|terminal bouton|multicellular organism development|animal organ development|T cell aggregation|regulation of cell adhesion|developmental pigmentation|membrane coat|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|cellular pigment accumulation|movement of cell or subcellular component|homeostatic process|establishment of organelle localization|positive regulation of leukocyte activation|cell activation|neuron projection|establishment of protein localization|cellular homeostasis|cellular pigmentation|protein localization|lymphocyte activation|regulation of cell activation|membrane organization|establishment of localization by movement along microtubule|establishment of localization in cell|positive regulation of cell adhesion|regulation of ion homeostasis|neuron projection terminus|regulation of sequestering of zinc ion|endosome membrane|sequestering of metal ion|cellular developmental process|microtubule-based process|endomembrane system organization|Golgi apparatus|endosome|organelle organization|vesicle-mediated transport|establishment of vesicle localization|regulation of lymphocyte activation|eye pigmentation|vesicle organization|axon|hemopoiesis|lymphocyte differentiation|synaptic vesicle membrane organization|chemical homeostasis|homotypic cell-cell adhesion|protein transport|synaptic vesicle transport|vacuole|intracellular transport|cellular chemical homeostasis|positive regulation of lymphocyte activation|axon terminus|regulation of cell-cell adhesion|axo-dendritic transport|pigment granule organization|protein localization to membrane|nuclear lumen|microtubule-based movement|leukocyte cell-cell adhesion|nucleoplasm|cellular protein localization|T cell activation|pigment cell differentiation|sequestering of zinc ion|Golgi membrane|vesicle localization|cell differentiation|positive regulation of cell-cell adhesion|organelle transport along microtubule|nucleus|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|pigment granule maturation|leukocyte differentiation|protein localization to organelle|regulation of T cell activation|melanosome organization|lytic vacuole|vesicle transport along microtubule|eye pigment biosynthetic process|T cell differentiation|anterograde axonal transport|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|alpha-beta T cell activation|cytosolic transport|intracellular protein transport|endosomal transport|ion homeostasis|positive regulation of T cell activation|cytoskeleton-dependent intracellular transport|positive regulation of lymphocyte differentiation|lysosomal membrane|cellular ion homeostasis|positive regulation of leukocyte cell-cell adhesion|positive regulation of T cell differentiation|lysosome|alpha-beta T cell differentiation|regulation of T cell differentiation|anterograde synaptic vesicle transport|endosome to melanosome transport|lymphocyte aggregation|cellular cation homeostasis|positive regulation of alpha-beta T cell differentiation|metal ion homeostasis|cellular metal ion homeostasis|NK T cell differentiation|cellular zinc ion homeostasis|zinc ion homeostasis|positive regulation of NK T cell differentiation K12396 AP-3 complex subunit delta-1[-] hsa04142 Lysosome - Homo sapiens (human) 19:2100988-2164465 817 977 1327 2874 3360 2742 3.27285108716056 3.55695919159726 4.7928024509085 10.3154612664903 11.0436191442304 10.2943912817325 3.87420424322211 10.5511572308177 -1.44542932150886 1.01873944428197e-11 3.10341299689734e-10 DOWN ENSG00000112031 MTRF1L mitochondrial translational release factor 1 like [Source:HGNC Symbol;Acc:HGNC:21051] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0044877|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0003676|GO:0043021|GO:0034641|GO:0043231|GO:0005737|GO:0044249|GO:0019538|GO:0006996|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0005759|GO:0005739|GO:0043022|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0032543|GO:0043241|GO:0043043|GO:0006412|GO:0008135|GO:0070126|GO:0043624|GO:0006415|GO:0008079|GO:0003747|GO:0016149 cell|cellular process|metabolic process|binding|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|nucleic acid binding|ribonucleoprotein complex binding|cellular nitrogen compound metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular biosynthetic process|protein metabolic process|organelle organization|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|mitochondrial matrix|mitochondrion|ribosome binding|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|mitochondrial translation|protein complex disassembly|peptide biosynthetic process|translation|translation factor activity, RNA binding|mitochondrial translational termination|cellular protein complex disassembly|translational termination|translation termination factor activity|translation release factor activity|translation release factor activity, codon specific - - - - 6:152987362-153002685 1125 1297 957 398 537 361 14.8468163804757 15.5561048639042 11.3869453683847 4.70610929118724 5.81463974997104 4.46496013089991 13.9299555375882 4.99523639068606 1.47956579534664 1.01789893706451e-11 3.10341299689734e-10 UP ENSG00000075151 EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 [Source:HGNC Symbol;Acc:HGNC:3298] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0016032|GO:0003676|GO:0034641|GO:0006413|GO:0005737|GO:0016281|GO:0007154|GO:0007165|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0007166|GO:0034097|GO:0006446|GO:0043603|GO:0044267|GO:0010467|GO:0071310|GO:0051246|GO:0009059|GO:0043043|GO:0019221|GO:0000339|GO:0010608|GO:0006412|GO:0006417|GO:0071345|GO:0044822|GO:0008135|GO:0003743 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|viral process|nucleic acid binding|cellular nitrogen compound metabolic process|translational initiation|cytoplasm|eukaryotic translation initiation factor 4F complex|cell communication|signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|cell surface receptor signaling pathway|response to cytokine|regulation of translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|cellular response to organic substance|regulation of protein metabolic process|macromolecule biosynthetic process|peptide biosynthetic process|cytokine-mediated signaling pathway|RNA cap binding|posttranscriptional regulation of gene expression|translation|regulation of translation|cellular response to cytokine stimulus|poly(A) RNA binding|translation factor activity, RNA binding|translation initiation factor activity K03260 translation initiation factor 4G[-] hsa03013|hsa05416 RNA transport - Homo sapiens (human)|Viral myocarditis - Homo sapiens (human) 1:20806292-21176888 428 529 709 1545 1605 2149 2.14505855333297 2.40952339694528 3.20373181022244 6.93780042437575 6.59991925034886 10.0939477165452 2.58610458683356 7.8772224637566 -1.60690639844522 1.02625923716717e-11 3.11995348944896e-10 DOWN ENSG00000186908 ZDHHC17 zinc finger, DHHC-type containing 17 [Source:HGNC Symbol;Acc:HGNC:18412] GO:0004871|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0022857|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0042802|GO:0006810|GO:0030660|GO:0031982|GO:0043231|GO:0043169|GO:0016746|GO:0005737|GO:0012506|GO:0009966|GO:0045184|GO:0022891|GO:0010646|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0005794|GO:1902533|GO:0005798|GO:0034645|GO:0046872|GO:0043412|GO:0031410|GO:0015031|GO:0042953|GO:0016023|GO:0036211|GO:0015075|GO:0042157|GO:0031988|GO:0016747|GO:0035556|GO:0030659|GO:0044267|GO:0000139|GO:0009059|GO:1902531|GO:1903830|GO:0043122|GO:0016409|GO:0043123|GO:0007249|GO:0042158|GO:0046914|GO:0006464|GO:0008324|GO:0019706|GO:0022890|GO:0006497|GO:0008270|GO:0018345|GO:0046873|GO:0015095 signal transducer activity|transporter activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|transmembrane transporter activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|identical protein binding|transport|Golgi-associated vesicle membrane|vesicle|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|cytoplasm|vesicle membrane|regulation of signal transduction|establishment of protein localization|substrate-specific transmembrane transporter activity|regulation of cell communication|protein localization|cell communication|transmembrane transport|signal transduction|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|Golgi apparatus|positive regulation of intracellular signal transduction|Golgi-associated vesicle|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|cytoplasmic vesicle|protein transport|lipoprotein transport|cytoplasmic, membrane-bounded vesicle|protein modification process|ion transmembrane transporter activity|lipoprotein metabolic process|membrane-bounded vesicle|transferase activity, transferring acyl groups other than amino-acyl groups|intracellular signal transduction|cytoplasmic vesicle membrane|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|regulation of intracellular signal transduction|magnesium ion transmembrane transport|regulation of I-kappaB kinase/NF-kappaB signaling|palmitoyltransferase activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|lipoprotein biosynthetic process|transition metal ion binding|cellular protein modification process|cation transmembrane transporter activity|protein-cysteine S-palmitoyltransferase activity|inorganic cation transmembrane transporter activity|protein lipidation|zinc ion binding|protein palmitoylation|metal ion transmembrane transporter activity|magnesium ion transmembrane transporter activity - - - - 12:76763588-76853696 13 12 40 138 203 130 0.0774309067700063 0.0649585403291372 0.214807623064567 0.736463208882028 0.99206134396408 0.725682439403788 0.11906569005457 0.818068997416632 -2.78046478142985 1.02597121776154e-11 3.11995348944896e-10 DOWN ENSG00000179454 KLHL28 kelch like family member 28 [Source:HGNC Symbol;Acc:HGNC:19741] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0009056|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0030163|GO:0004842|GO:0031461|GO:0044265|GO:0036211|GO:1990234|GO:0006508|GO:0044267|GO:0044257|GO:0051603|GO:0006464|GO:0031463|GO:0019941|GO:0032446|GO:0006511|GO:0042787|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|catabolic process|cellular metabolic process|intracellular|protein binding|protein complex|transferase activity|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|cellular macromolecule catabolic process|protein modification process|transferase complex|proteolysis|cellular protein metabolic process|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|cellular protein modification process|Cul3-RING ubiquitin ligase complex|modification-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - 14:44924319-45042322 1217 1399 2505 250 505 572 8.17771016389524 8.54355722262675 15.1761991526227 1.50514868490665 2.78419867730888 3.60218879976081 10.6324888463816 2.63051205399211 2.01506377538883 1.05410023281219e-11 3.20133350461599e-10 UP ENSG00000115419 GLS glutaminase [Source:HGNC Symbol;Acc:HGNC:4331] GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0007631|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0007269|GO:0005515|GO:0043576|GO:0007585|GO:0006725|GO:0006810|GO:1901360|GO:0006082|GO:0050877|GO:0034641|GO:0044281|GO:0032940|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0006520|GO:0007267|GO:0016810|GO:0001967|GO:0006139|GO:0007154|GO:0003016|GO:0051649|GO:0001505|GO:0044249|GO:0006836|GO:0005829|GO:0034645|GO:0002087|GO:0016811|GO:0006811|GO:0009063|GO:0008652|GO:0005759|GO:0005739|GO:0006461|GO:0044065|GO:0010467|GO:0046903|GO:0009059|GO:0016070|GO:0014047|GO:0006820|GO:0015711|GO:0051259|GO:0032774|GO:0046395|GO:0004359|GO:0046942|GO:0019752|GO:0006865|GO:0046717|GO:0006351|GO:0006366|GO:0006541|GO:0006352|GO:0043648|GO:0006835|GO:0051260|GO:0051262|GO:0007268|GO:0006536|GO:0006367|GO:0006543|GO:0051289|GO:0006537 behavior|signaling|cell|cellular process|metabolic process|binding|catalytic activity|feeding behavior|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|neurotransmitter secretion|protein binding|regulation of respiratory gaseous exchange|respiratory gaseous exchange|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|organic acid metabolic process|neurological system process|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|cell-cell signaling|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|suckling behavior|nucleobase-containing compound metabolic process|cell communication|respiratory system process|establishment of localization in cell|regulation of neurotransmitter levels|cellular biosynthetic process|neurotransmitter transport|cytosol|cellular macromolecule biosynthetic process|regulation of respiratory gaseous exchange by neurological system process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|ion transport|cellular amino acid catabolic process|cellular amino acid biosynthetic process|mitochondrial matrix|mitochondrion|protein complex assembly|regulation of respiratory system process|gene expression|secretion|macromolecule biosynthetic process|RNA metabolic process|glutamate secretion|anion transport|organic anion transport|protein oligomerization|RNA biosynthetic process|carboxylic acid catabolic process|glutaminase activity|carboxylic acid transport|carboxylic acid metabolic process|amino acid transport|acid secretion|transcription, DNA-templated|transcription from RNA polymerase II promoter|glutamine metabolic process|DNA-templated transcription, initiation|dicarboxylic acid metabolic process|dicarboxylic acid transport|protein homooligomerization|protein tetramerization|synaptic transmission|glutamate metabolic process|transcription initiation from RNA polymerase II promoter|glutamine catabolic process|protein homotetramerization|glutamate biosynthetic process K01425 glutaminase[3.5.1.2] hsa01100|hsa05206|hsa04724|hsa04727|hsa05230|hsa00250|hsa04964|hsa00220|hsa00471 Metabolic pathways - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human)|Proximal tubule bicarbonate reclamation - Homo sapiens (human)|Arginine biosynthesis - Homo sapiens (human)|D-Glutamine and D-glutamate metabolism - Homo sapiens (human) 2:190880827-190965552 789 982 1432 2942 3193 3963 3.66649576097646 4.14729940158731 5.99972194971483 12.2493880426046 12.1742118367728 17.2594541302776 4.60450570409287 13.8943513365517 -1.59338028757194 1.08907846595538e-11 3.30420208563332e-10 DOWN ENSG00000078618 NRD1 nardilysin convertase [Source:HGNC Symbol;Acc:HGNC:7995] GO:0040011|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0008283|GO:0050794|GO:0042562|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0009986|GO:0044237|GO:0048870|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0005622|GO:0005515|GO:0019222|GO:0019838|GO:0031325|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0006928|GO:0016477|GO:0050808|GO:0050790|GO:0048408|GO:0019538|GO:0031323|GO:0032268|GO:0005829|GO:0045732|GO:0046872|GO:0030163|GO:0007528|GO:0051604|GO:0051247|GO:0006508|GO:0005739|GO:0032270|GO:0044267|GO:0042176|GO:0010467|GO:0051246|GO:0008237|GO:0016485|GO:0030162|GO:0045862|GO:0033619|GO:0052547|GO:0004175|GO:0051044|GO:0046914|GO:0006509|GO:0008270|GO:0004222|GO:0052548 locomotion|cell|cellular process|metabolic process|binding|catalytic activity|cell proliferation|regulation of cellular process|hormone binding|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cell surface|cellular metabolic process|cell motility|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|intracellular|protein binding|regulation of metabolic process|growth factor binding|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|movement of cell or subcellular component|cell migration|synapse organization|regulation of catalytic activity|epidermal growth factor binding|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|positive regulation of protein catabolic process|metal ion binding|protein catabolic process|neuromuscular junction development|protein maturation|positive regulation of protein metabolic process|proteolysis|mitochondrion|positive regulation of cellular protein metabolic process|cellular protein metabolic process|regulation of protein catabolic process|gene expression|regulation of protein metabolic process|metallopeptidase activity|protein processing|regulation of proteolysis|positive regulation of proteolysis|membrane protein proteolysis|regulation of peptidase activity|endopeptidase activity|positive regulation of membrane protein ectodomain proteolysis|transition metal ion binding|membrane protein ectodomain proteolysis|zinc ion binding|metalloendopeptidase activity|regulation of endopeptidase activity - - - - 1:51789191-51878937 1598 1820 2582 5794 5841 5495 10.4239642388538 10.7896599346969 15.1854166692065 33.863545295931 31.2616158948348 33.5933176154161 12.1330136142524 32.9061596020606 -1.43941972934943 1.12624177193838e-11 3.41348445273588e-10 DOWN ENSG00000147475 ERLIN2 ER lipid raft associated 2 [Source:HGNC Symbol;Acc:HGNC:1356] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0044255|GO:0006725|GO:1901360|GO:0006082|GO:0005496|GO:0034641|GO:0044281|GO:0031982|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043178|GO:0019899|GO:0005737|GO:0009890|GO:0006139|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0070062|GO:0042180|GO:0045833|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0006991|GO:0036503|GO:0010468|GO:0034645|GO:0030163|GO:0006984|GO:0051252|GO:0006066|GO:0006631|GO:0044265|GO:0010628|GO:0051055|GO:0032934|GO:0030433|GO:0045939|GO:0006508|GO:0010565|GO:0008202|GO:0044267|GO:0010467|GO:0008610|GO:0019216|GO:0046890|GO:0031328|GO:0045922|GO:0009059|GO:0045121|GO:0016070|GO:0034976|GO:0010557|GO:0044389|GO:0045541|GO:0019217|GO:0031625|GO:0044257|GO:0045893|GO:0010498|GO:0032774|GO:0019218|GO:2001141|GO:0006694|GO:0051603|GO:0006633|GO:0032933|GO:0050810|GO:0016125|GO:0010894|GO:0045717|GO:0019752|GO:0015485|GO:0042304|GO:0006351|GO:0045540|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0019941|GO:1903506|GO:0016126|GO:0090181|GO:0008203|GO:0032787|GO:0043161|GO:0006511|GO:0006695 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|cellular lipid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|steroid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|alcohol binding|enzyme binding|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|extracellular exosome|cellular ketone metabolic process|negative regulation of lipid metabolic process|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to sterol depletion|ERAD pathway|regulation of gene expression|cellular macromolecule biosynthetic process|protein catabolic process|ER-nucleus signaling pathway|regulation of RNA metabolic process|alcohol metabolic process|fatty acid metabolic process|cellular macromolecule catabolic process|positive regulation of gene expression|negative regulation of lipid biosynthetic process|sterol binding|ER-associated ubiquitin-dependent protein catabolic process|negative regulation of steroid metabolic process|proteolysis|regulation of cellular ketone metabolic process|steroid metabolic process|cellular protein metabolic process|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|negative regulation of fatty acid metabolic process|macromolecule biosynthetic process|membrane raft|RNA metabolic process|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|ubiquitin-like protein ligase binding|negative regulation of cholesterol biosynthetic process|regulation of fatty acid metabolic process|ubiquitin protein ligase binding|cellular protein catabolic process|positive regulation of transcription, DNA-templated|proteasomal protein catabolic process|RNA biosynthetic process|regulation of steroid metabolic process|regulation of RNA biosynthetic process|steroid biosynthetic process|proteolysis involved in cellular protein catabolic process|fatty acid biosynthetic process|SREBP signaling pathway|regulation of steroid biosynthetic process|sterol metabolic process|negative regulation of steroid biosynthetic process|negative regulation of fatty acid biosynthetic process|carboxylic acid metabolic process|cholesterol binding|regulation of fatty acid biosynthetic process|transcription, DNA-templated|regulation of cholesterol biosynthetic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|sterol biosynthetic process|regulation of cholesterol metabolic process|cholesterol metabolic process|monocarboxylic acid metabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|cholesterol biosynthetic process - - - - 8:37736599-37759101 247 289 426 935 936 1063 1.09783338423236 1.16739307103418 1.70711378691227 3.72347329335288 3.41336474985767 4.42793351745615 1.3241134140596 3.85492385355557 -1.54167566446772 1.13756921443587e-11 3.44431960727875e-10 DOWN ENSG00000129347 KRI1 KRI1 homolog [Source:HGNC Symbol;Acc:HGNC:25769] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 19:10553078-10566037 1308 1362 1034 452 539 453 8.38077964654694 7.93110752992066 5.97325818001853 2.59485358741926 2.83356843433093 2.72021558368456 7.42838178549538 2.71621253514492 1.45145159485202 1.14994812254817e-11 3.47827266976221e-10 UP ENSG00000110104 CCDC86 coiled-coil domain containing 86 [Source:HGNC Symbol;Acc:HGNC:28359] GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0016032|GO:0003676|GO:0043231|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|cellular process|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|viral process|nucleic acid binding|intracellular membrane-bounded organelle|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 11:60842071-60851081 2818 2660 1913 820 947 486 54.3447265323814 46.6206289333663 33.2617892374347 14.1686390255941 14.9842320098192 8.78377636541546 44.7423815677275 12.6455491336096 1.82301236339873 1.1562694524962e-11 3.4938530602046e-10 UP ENSG00000117877 CD3EAP CD3e molecule, epsilon associated protein [Source:HGNC Symbol;Acc:HGNC:24219] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016772|GO:0046483|GO:0043231|GO:0005737|GO:0005667|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0005730|GO:0010468|GO:0034645|GO:0003723|GO:0007166|GO:0044798|GO:0010629|GO:0031981|GO:1990234|GO:0005654|GO:0005739|GO:0005694|GO:0010467|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0005736|GO:0045814|GO:0032774|GO:0034660|GO:0040029|GO:0007167|GO:0044822|GO:0006351|GO:0000120|GO:0006352|GO:0003899|GO:0006360|GO:0006354|GO:0006353|GO:0007169|GO:0009303|GO:0006361|GO:0006362|GO:0006363 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|transcription factor complex|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|nucleolus|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|cell surface receptor signaling pathway|nuclear transcription factor complex|negative regulation of gene expression|nuclear lumen|transferase complex|nucleoplasm|mitochondrion|chromosome|gene expression|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|DNA-directed RNA polymerase I complex|negative regulation of gene expression, epigenetic|RNA biosynthetic process|ncRNA metabolic process|regulation of gene expression, epigenetic|enzyme linked receptor protein signaling pathway|poly(A) RNA binding|transcription, DNA-templated|RNA polymerase I transcription factor complex|DNA-templated transcription, initiation|DNA-directed RNA polymerase activity|transcription from RNA polymerase I promoter|DNA-templated transcription, elongation|DNA-templated transcription, termination|transmembrane receptor protein tyrosine kinase signaling pathway|rRNA transcription|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription - - - - 19:45406209-45410766 869 960 613 223 274 107 9.42218708663895 9.45982079172631 5.99247567052459 2.16637787319647 2.43753311449087 1.08729176474112 8.29149451629662 1.89706758414282 2.12786108996821 1.17069793460486e-11 3.5338742305049e-10 UP ENSG00000067369 TP53BP1 tumor protein p53 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:11999] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0007049|GO:0006281|GO:0003712|GO:0006725|GO:0042393|GO:0009314|GO:0022402|GO:1901360|GO:0002039|GO:0034641|GO:0000776|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0001076|GO:0006139|GO:0008134|GO:0044249|GO:0031323|GO:0051090|GO:0010468|GO:0000075|GO:0034645|GO:0000725|GO:0001104|GO:0001085|GO:0051252|GO:0010628|GO:0006302|GO:0051091|GO:0031981|GO:0071478|GO:0005654|GO:0006259|GO:0005694|GO:0010212|GO:0010467|GO:0035064|GO:0031328|GO:0009059|GO:0016070|GO:0033613|GO:0010557|GO:0005634|GO:0000777|GO:0006974|GO:0006303|GO:0000724|GO:0045893|GO:0001102|GO:0000781|GO:0032774|GO:0000793|GO:2001141|GO:0000077|GO:0006310|GO:0071479|GO:0010165|GO:0006351|GO:0006355|GO:0000775|GO:0045944|GO:0006366|GO:0000779|GO:0006357|GO:1903506|GO:0071481 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cell cycle|DNA repair|transcription cofactor activity|cellular aromatic compound metabolic process|histone binding|response to radiation|cell cycle process|organic cyclic compound metabolic process|p53 binding|cellular nitrogen compound metabolic process|kinetochore|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|transcription factor activity, RNA polymerase II transcription factor binding|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|recombinational repair|RNA polymerase II transcription cofactor activity|RNA polymerase II transcription factor binding|regulation of RNA metabolic process|positive regulation of gene expression|double-strand break repair|positive regulation of sequence-specific DNA binding transcription factor activity|nuclear lumen|cellular response to radiation|nucleoplasm|DNA metabolic process|chromosome|response to ionizing radiation|gene expression|methylated histone binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|activating transcription factor binding|positive regulation of macromolecule biosynthetic process|nucleus|condensed chromosome kinetochore|cellular response to DNA damage stimulus|double-strand break repair via nonhomologous end joining|double-strand break repair via homologous recombination|positive regulation of transcription, DNA-templated|RNA polymerase II activating transcription factor binding|chromosome, telomeric region|RNA biosynthetic process|condensed chromosome|regulation of RNA biosynthetic process|DNA damage checkpoint|DNA recombination|cellular response to ionizing radiation|response to X-ray|transcription, DNA-templated|regulation of transcription, DNA-templated|chromosome, centromeric region|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|condensed chromosome, centromeric region|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|cellular response to X-ray - - - - 15:43403061-43510728 619 714 831 1922 1956 2134 2.43784290539812 2.55560350391244 2.95073731240005 6.78213324117618 6.32050981893228 7.87659656239361 2.6480612405702 6.99307987416736 -1.4009914964647 1.18220965674441e-11 3.5614215027697e-10 DOWN ENSG00000198156 NPIPB6 nuclear pore complex interacting protein family member B6 [Source:HGNC Symbol;Acc:HGNC:37454] - - - - - - 16:28342555-28363508 94 117 102 13 29 27 3.11441977605246 3.52301862665527 3.04691384477919 0.385910550249568 0.788326942580838 0.838373150093487 3.22811741582897 0.670870214307964 2.2665874579017 1.18128413946927e-11 3.5614215027697e-10 UP ENSG00000134014 ELP3 elongator acetyltransferase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:20696] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0040017|GO:0016043|GO:0043227|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0051272|GO:0008023|GO:0033588|GO:0006725|GO:1901360|GO:0051536|GO:0007275|GO:0016570|GO:0034641|GO:0046483|GO:2000147|GO:0043231|GO:0043169|GO:0019899|GO:0016746|GO:0005737|GO:0006928|GO:0032403|GO:0006139|GO:0051270|GO:0016477|GO:0050790|GO:0019207|GO:0048869|GO:2000145|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0032268|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0007417|GO:0019887|GO:0051252|GO:0006325|GO:0016573|GO:0030334|GO:0036211|GO:0001764|GO:0070063|GO:0031981|GO:1990234|GO:0005654|GO:0016747|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0007399|GO:0000993|GO:0000123|GO:0051246|GO:0009059|GO:0030154|GO:0030335|GO:0016070|GO:0005634|GO:0006396|GO:0032774|GO:0034660|GO:2001141|GO:0043966|GO:0043967|GO:0016310|GO:0043175|GO:0009451|GO:0008607|GO:0016407|GO:0016410|GO:0016568|GO:0022008|GO:0006464|GO:0043549|GO:0006351|GO:0006355|GO:0006400|GO:0006366|GO:0045859|GO:0006357|GO:0006468|GO:0048699|GO:1903506|GO:0042325|GO:0006354|GO:0006399|GO:0001932|GO:0018193|GO:0008080|GO:0008033|GO:0006368|GO:0006473|GO:0018205|GO:0018394|GO:0002098|GO:0006475|GO:0018393|GO:0004402|GO:0010485|GO:0010484 locomotion|developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|positive regulation of locomotion|cellular component organization|membrane-bounded organelle|biosynthetic process|enzyme regulator activity|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|positive regulation of cellular component movement|transcription elongation factor complex|Elongator holoenzyme complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|iron-sulfur cluster binding|multicellular organism development|histone modification|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell motility|intracellular membrane-bounded organelle|cation binding|enzyme binding|transferase activity, transferring acyl groups|cytoplasm|movement of cell or subcellular component|protein complex binding|nucleobase-containing compound metabolic process|regulation of cellular component movement|cell migration|regulation of catalytic activity|kinase regulator activity|cellular developmental process|regulation of cell motility|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|central nervous system development|protein kinase regulator activity|regulation of RNA metabolic process|chromatin organization|histone acetylation|regulation of cell migration|protein modification process|neuron migration|RNA polymerase binding|nuclear lumen|transferase complex|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|nervous system development|RNA polymerase II core binding|histone acetyltransferase complex|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|positive regulation of cell migration|RNA metabolic process|nucleus|RNA processing|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|histone H3 acetylation|histone H4 acetylation|phosphorylation|RNA polymerase core enzyme binding|RNA modification|phosphorylase kinase regulator activity|acetyltransferase activity|N-acyltransferase activity|chromatin modification|neurogenesis|cellular protein modification process|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|tRNA modification|transcription from RNA polymerase II promoter|regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of phosphorylation|DNA-templated transcription, elongation|tRNA metabolic process|regulation of protein phosphorylation|peptidyl-amino acid modification|N-acetyltransferase activity|tRNA processing|transcription elongation from RNA polymerase II promoter|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|tRNA wobble uridine modification|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity|H4 histone acetyltransferase activity|H3 histone acetyltransferase activity - - - - 8:28089673-28191156 110 161 209 571 584 498 0.729038061373807 0.96976352097705 1.24887526949944 3.39072580655558 3.1757030197068 3.09326915453737 0.982558950616766 3.21989932693325 -1.71239970938363 1.20890220175633e-11 3.63816192855177e-10 DOWN ENSG00000236255 AC009404.2 - - - - - - - 2:117833937-117841658 236 252 248 52 75 89 3.72465773921324 3.61454710484728 3.52890593598004 0.735313721359062 0.971191920049212 1.31642280742332 3.62270359334685 1.0076428162772 1.84608243969266 1.24326316196081e-11 3.7378024609444e-10 UP ENSG00000139117 CPNE8 copine VIII [Source:HGNC Symbol;Acc:HGNC:23498] GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0005515|GO:0031982|GO:0070062 extracellular region|binding|extracellular vesicle|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 12:38646822-38907430 60 44 130 361 404 474 0.507620208077574 0.338313753316476 0.991621398697709 2.73647725312962 2.80438115409209 3.75832941598623 0.61251845336392 3.09972927440265 -2.33931700422671 1.27229875420298e-11 3.82124818993719e-10 DOWN ENSG00000065526 SPEN spen family transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:17575] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0031982|GO:0046483|GO:0045597|GO:0043231|GO:0001076|GO:0017053|GO:0009890|GO:0006139|GO:0007154|GO:0007165|GO:0070062|GO:0008134|GO:0000166|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:0003723|GO:0007166|GO:0001085|GO:0010629|GO:0010720|GO:0051252|GO:0031981|GO:0050769|GO:0005654|GO:0010467|GO:0007399|GO:0009059|GO:0030154|GO:0001191|GO:0016070|GO:0005634|GO:0051960|GO:0006396|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0016071|GO:0044822|GO:0007219|GO:0022008|GO:0050767|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:1903506|GO:0006397|GO:0008380|GO:0000122|GO:0000375|GO:0000398 developmental process|macromolecular complex|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|viral process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|positive regulation of cell differentiation|intracellular membrane-bounded organelle|transcription factor activity, RNA polymerase II transcription factor binding|transcriptional repressor complex|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|signal transduction|extracellular exosome|transcription factor binding|nucleotide binding|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|cell surface receptor signaling pathway|RNA polymerase II transcription factor binding|negative regulation of gene expression|positive regulation of cell development|regulation of RNA metabolic process|nuclear lumen|positive regulation of neurogenesis|nucleoplasm|gene expression|nervous system development|macromolecule biosynthetic process|cell differentiation|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|nucleus|regulation of nervous system development|RNA processing|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|mRNA metabolic process|poly(A) RNA binding|Notch signaling pathway|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|mRNA processing|RNA splicing|negative regulation of transcription from RNA polymerase II promoter|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 1:15847864-15940460 2765 3033 2636 1214 1333 1088 13.5102170637667 13.4685128844193 11.6125306638353 5.31476067805592 5.34398443008256 4.98224197796565 12.8637535373404 5.21366236203471 1.30294260887556 1.27841072661087e-11 3.83239338284437e-10 UP ENSG00000171621 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:30628] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0005737|GO:0007154|GO:0007165|GO:0019538|GO:0043412|GO:0036211|GO:0035556|GO:0044267|GO:0006464|GO:0032446|GO:0016567 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|cytoplasm|cell communication|signal transduction|protein metabolic process|macromolecule modification|protein modification process|intracellular signal transduction|cellular protein metabolic process|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination - - - - 1:9292880-9369532 96 118 176 418 483 474 1.22466246127472 1.36806161322456 2.02428677331048 4.77769138587705 5.05544629083212 5.66697786240954 1.53900361593659 5.16670517970624 -1.74724794234496 1.27986072308429e-11 3.83239338284437e-10 DOWN ENSG00000236349 SUCLG2P2 succinate-CoA ligase, GDP-forming, beta subunit pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:43997] - - - - - - 12:94548241-94549536 8 3 9 54 58 52 0.436626931778797 0.148836675073363 0.442877387186383 2.64076991076002 2.59738747389592 2.65993970690104 0.342780331346181 2.63269903051899 -2.9411863668419 1.27968263596892e-11 3.83239338284437e-10 DOWN ENSG00000163961 RNF168 ring finger protein 168, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:26661] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0016874|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0002250|GO:0006281|GO:0032182|GO:0016445|GO:0006725|GO:0042393|GO:0009314|GO:1901360|GO:2001022|GO:0045190|GO:0007275|GO:0016570|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0002377|GO:0032403|GO:0001775|GO:0002312|GO:0002263|GO:0009890|GO:0003682|GO:0006139|GO:0046649|GO:0002366|GO:0019787|GO:0000151|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0002443|GO:0006996|GO:0051276|GO:0042113|GO:0010468|GO:0034645|GO:0046872|GO:0000725|GO:0043412|GO:0030163|GO:0010629|GO:0004842|GO:0016447|GO:0043130|GO:0051252|GO:0006325|GO:0044265|GO:0006302|GO:0036211|GO:0036297|GO:0045739|GO:0035861|GO:0031981|GO:2001020|GO:1990234|GO:0006508|GO:0016574|GO:0005654|GO:0031491|GO:0006259|GO:0005694|GO:0002460|GO:0006282|GO:0051054|GO:0010212|GO:0002381|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006974|GO:0006303|GO:0044257|GO:0000724|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0010390|GO:0033522|GO:0051603|GO:0006310|GO:0046914|GO:0016568|GO:0019724|GO:0031593|GO:0006464|GO:0002204|GO:0006351|GO:0006355|GO:0016064|GO:0006366|GO:0032784|GO:1903507|GO:0032785|GO:0006357|GO:0019941|GO:1903506|GO:0070535|GO:0006354|GO:0018193|GO:0016444|GO:0070530|GO:0035518|GO:0036351|GO:0043687|GO:0000122|GO:0036352|GO:0008270|GO:0032446|GO:0006511|GO:0006368|GO:0034243|GO:0034244|GO:0018205|GO:0016925|GO:0016567|GO:0006513|GO:0000209|GO:0070534 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|ligase activity|intracellular|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|adaptive immune response|DNA repair|ubiquitin-like protein binding|somatic diversification of immunoglobulins|cellular aromatic compound metabolic process|histone binding|response to radiation|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|isotype switching|multicellular organism development|histone modification|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|immunoglobulin production|protein complex binding|cell activation|B cell activation involved in immune response|cell activation involved in immune response|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|lymphocyte activation|leukocyte activation involved in immune response|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|leukocyte mediated immunity|organelle organization|chromosome organization|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|recombinational repair|macromolecule modification|protein catabolic process|negative regulation of gene expression|ubiquitin-protein transferase activity|somatic recombination of immunoglobulin gene segments|ubiquitin binding|regulation of RNA metabolic process|chromatin organization|cellular macromolecule catabolic process|double-strand break repair|protein modification process|interstrand cross-link repair|positive regulation of DNA repair|site of double-strand break|nuclear lumen|regulation of response to DNA damage stimulus|transferase complex|proteolysis|histone ubiquitination|nucleoplasm|nucleosome binding|DNA metabolic process|chromosome|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|regulation of DNA repair|positive regulation of DNA metabolic process|response to ionizing radiation|immunoglobulin production involved in immunoglobulin mediated immune response|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|double-strand break repair via nonhomologous end joining|cellular protein catabolic process|double-strand break repair via homologous recombination|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|histone monoubiquitination|histone H2A ubiquitination|proteolysis involved in cellular protein catabolic process|DNA recombination|transition metal ion binding|chromatin modification|B cell mediated immunity|polyubiquitin binding|cellular protein modification process|somatic recombination of immunoglobulin genes involved in immune response|transcription, DNA-templated|regulation of transcription, DNA-templated|immunoglobulin mediated immune response|transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|negative regulation of nucleic acid-templated transcription|negative regulation of DNA-templated transcription, elongation|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|histone H2A K63-linked ubiquitination|DNA-templated transcription, elongation|peptidyl-amino acid modification|somatic cell DNA recombination|K63-linked polyubiquitin binding|histone H2A monoubiquitination|histone H2A-K13 ubiquitination|post-translational protein modification|negative regulation of transcription from RNA polymerase II promoter|histone H2A-K15 ubiquitination|zinc ion binding|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|transcription elongation from RNA polymerase II promoter|regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter|peptidyl-lysine modification|protein sumoylation|protein ubiquitination|protein monoubiquitination|protein polyubiquitination|protein K63-linked ubiquitination - - - - 3:196468783-196503768 2729 3037 3509 1229 1446 1468 26.9422012064366 27.2492407866092 31.23396287167 10.8712450894923 11.7129403330898 13.5826480966238 28.4751349549053 12.0556111730686 1.23999788757271 1.29213111776144e-11 3.86525875647796e-10 UP ENSG00000111816 FRK fyn-related Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3955] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0019898|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0042127|GO:0009898|GO:0045087|GO:0005102|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031982|GO:0043231|GO:0005737|GO:0031234|GO:0098562|GO:0019897|GO:0007154|GO:0007165|GO:0070062|GO:0008285|GO:0000166|GO:0048869|GO:0019538|GO:0007166|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0030154|GO:0016773|GO:0005634|GO:0005524|GO:0030554|GO:0016310|GO:0007167|GO:0004672|GO:0006464|GO:0006468|GO:0004713|GO:0018193|GO:0007169|GO:0004715|GO:0046777|GO:0018108|GO:0038083 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|transferase activity|regulation of cell proliferation|cytoplasmic side of plasma membrane|innate immune response|receptor binding|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|intracellular membrane-bounded organelle|cytoplasm|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|extrinsic component of plasma membrane|cell communication|signal transduction|extracellular exosome|negative regulation of cell proliferation|nucleotide binding|cellular developmental process|protein metabolic process|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|cell differentiation|phosphotransferase activity, alcohol group as acceptor|nucleus|ATP binding|adenyl nucleotide binding|phosphorylation|enzyme linked receptor protein signaling pathway|protein kinase activity|cellular protein modification process|protein phosphorylation|protein tyrosine kinase activity|peptidyl-amino acid modification|transmembrane receptor protein tyrosine kinase signaling pathway|non-membrane spanning protein tyrosine kinase activity|protein autophosphorylation|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation - - - - 6:115931149-116060758 128 116 273 640 696 904 0.684375935227401 0.563667954737117 1.31602224722627 3.06594098155112 3.05325547951847 4.52984573800077 0.854688712396929 3.54968073302345 -2.05421829652299 1.30379183894449e-11 3.89623639237727e-10 DOWN ENSG00000100784 RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 [Source:HGNC Symbol;Acc:HGNC:10434] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0001818|GO:0002757|GO:0006935|GO:0045087|GO:0006725|GO:0048468|GO:0051130|GO:1901360|GO:0007275|GO:0016570|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0001817|GO:0043231|GO:0043169|GO:0005737|GO:0002218|GO:0001816|GO:0006928|GO:0009890|GO:0006139|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0000166|GO:0030030|GO:0048869|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0051090|GO:0000165|GO:0051276|GO:0032268|GO:0000902|GO:0031175|GO:0010468|GO:0034645|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0002758|GO:0034097|GO:0010629|GO:0016572|GO:0031056|GO:0051252|GO:0006325|GO:0001883|GO:0000904|GO:0031058|GO:0016573|GO:0010628|GO:0036211|GO:0006954|GO:0032549|GO:0051091|GO:0002429|GO:0031981|GO:0031098|GO:0051247|GO:0070848|GO:0005654|GO:0002764|GO:0016301|GO:0032270|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0017076|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0016773|GO:0010557|GO:0005634|GO:0045089|GO:0045088|GO:0010638|GO:0048666|GO:2001252|GO:0030182|GO:0007411|GO:0045893|GO:0019221|GO:0031401|GO:0070555|GO:0035404|GO:0045892|GO:0000287|GO:0032774|GO:0005524|GO:2001141|GO:0071363|GO:0030554|GO:0016310|GO:0033044|GO:0051092|GO:0002768|GO:0038179|GO:1902679|GO:0002221|GO:0035066|GO:0061564|GO:0007167|GO:0032793|GO:0035065|GO:0071345|GO:0004672|GO:0016568|GO:0033129|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0051403|GO:0006351|GO:0006355|GO:0043987|GO:0048011|GO:0045944|GO:0006366|GO:0043990|GO:0002223|GO:1903507|GO:0002224|GO:0071347|GO:0006357|GO:0035173|GO:0043988|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0042325|GO:0001932|GO:0018193|GO:0004674|GO:0001934|GO:1901985|GO:0042327|GO:0070498|GO:0007169|GO:0035174|GO:0034166|GO:0034134|GO:0038124|GO:0002756|GO:0018105|GO:0034138|GO:0002755|GO:0034146|GO:0034142|GO:0006473|GO:0038123|GO:0018205|GO:0034162|GO:0038127|GO:0018394|GO:0007173|GO:0035666|GO:0006475|GO:0035175|GO:0018393 locomotion|developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|negative regulation of cytokine production|immune response-activating signal transduction|chemotaxis|innate immune response|cellular aromatic compound metabolic process|cell development|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|histone modification|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|cytoplasm|activation of innate immune response|cytokine production|movement of cell or subcellular component|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|nucleotide binding|cell projection organization|cellular developmental process|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|MAPK cascade|chromosome organization|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|response to cytokine|negative regulation of gene expression|histone phosphorylation|regulation of histone modification|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|cell morphogenesis involved in differentiation|positive regulation of histone modification|histone acetylation|positive regulation of gene expression|protein modification process|inflammatory response|ribonucleoside binding|positive regulation of sequence-specific DNA binding transcription factor activity|immune response-activating cell surface receptor signaling pathway|nuclear lumen|stress-activated protein kinase signaling cascade|positive regulation of protein metabolic process|response to growth factor|nucleoplasm|immune response-regulating signaling pathway|kinase activity|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of innate immune response|regulation of innate immune response|positive regulation of organelle organization|neuron development|positive regulation of chromosome organization|neuron differentiation|axon guidance|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|positive regulation of protein modification process|response to interleukin-1|histone-serine phosphorylation|negative regulation of transcription, DNA-templated|magnesium ion binding|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|regulation of chromosome organization|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|negative regulation of RNA biosynthetic process|pattern recognition receptor signaling pathway|positive regulation of histone acetylation|axon development|enzyme linked receptor protein signaling pathway|positive regulation of CREB transcription factor activity|regulation of histone acetylation|cellular response to cytokine stimulus|protein kinase activity|chromatin modification|positive regulation of histone phosphorylation|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|stress-activated MAPK cascade|transcription, DNA-templated|regulation of transcription, DNA-templated|histone H3-S10 phosphorylation|neurotrophin TRK receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|histone H2A-S1 phosphorylation|stimulatory C-type lectin receptor signaling pathway|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|cellular response to interleukin-1|regulation of transcription from RNA polymerase II promoter|histone kinase activity|histone H3-S28 phosphorylation|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|positive regulation of protein acetylation|positive regulation of phosphorylation|interleukin-1-mediated signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|histone serine kinase activity|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|MyD88-independent toll-like receptor signaling pathway|peptidyl-serine phosphorylation|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|protein acetylation|toll-like receptor TLR1:TLR2 signaling pathway|peptidyl-lysine modification|toll-like receptor 9 signaling pathway|ERBB signaling pathway|peptidyl-lysine acetylation|epidermal growth factor receptor signaling pathway|TRIF-dependent toll-like receptor signaling pathway|internal protein amino acid acetylation|histone kinase activity (H3-S10 specific)|internal peptidyl-lysine acetylation K04445 ribosomal protein S6 kinase alpha-5[2.7.11.1] hsa05206|hsa04010|hsa04261|hsa04722|hsa04668|hsa04713|hsa05219 MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Bladder cancer - Homo sapiens (human) 14:90847862-91060636 3 7 16 62 69 83 0.00661783034982675 0.0140331006925898 0.0318194210148867 0.122528363741804 0.124871189986041 0.171575367441678 0.0174901173524344 0.139658307056508 -2.99728951516213 1.31416712984249e-11 3.92331454943178e-10 DOWN ENSG00000121542 SEC22A SEC22 homolog A, vesicle trafficking protein [Source:HGNC Symbol;Acc:HGNC:20260] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0042175|GO:0051641|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0005484|GO:0045184|GO:0000149|GO:0008104|GO:0061024|GO:0005783|GO:0051649|GO:0016021|GO:0006996|GO:0061025|GO:0016192|GO:0016050|GO:0015031|GO:0046907|GO:0048284|GO:0048193|GO:0006906|GO:0048280|GO:0006888 transporter activity|cell|membrane|cellular process|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|cellular localization|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|SNAP receptor activity|establishment of protein localization|SNARE binding|protein localization|membrane organization|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|organelle organization|membrane fusion|vesicle-mediated transport|vesicle organization|protein transport|intracellular transport|organelle fusion|Golgi vesicle transport|vesicle fusion|vesicle fusion with Golgi apparatus|ER to Golgi vesicle-mediated transport - - - - 3:123201927-123274130 59 60 110 319 302 308 0.61819669179588 0.571358039511801 1.03916241661639 2.99478873357337 2.59628780256453 3.0245220233079 0.74290571597469 2.87186618648193 -1.95073749744489 1.41361194627204e-11 4.21598112327728e-10 DOWN ENSG00000139865 TTC6 tetratricopeptide repeat domain 6 [Source:HGNC Symbol;Acc:HGNC:19739] GO:0005488|GO:0005515 binding|protein binding - - - - 14:37595847-38041442 8 8 7 60 54 111 0.053748908015323 0.0488505334947337 0.0424024496390697 0.361200885257028 0.297689732003188 0.698958439844408 0.0483339637163755 0.452616352368208 -3.22717949239921 1.4233156635689e-11 4.24068521159541e-10 DOWN ENSG00000174721 FGFBP3 fibroblast growth factor binding protein 3 [Source:HGNC Symbol;Acc:HGNC:23428] GO:0031012|GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043167|GO:0023051|GO:0005515|GO:0008201|GO:0019838|GO:0043168|GO:0090287|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0043114|GO:0009967|GO:0005539|GO:0010033|GO:0003013|GO:0071774|GO:0040036|GO:0007166|GO:0043117|GO:0044344|GO:0070848|GO:0071310|GO:0045743|GO:0008015|GO:0017134|GO:0008543|GO:0071363|GO:0007167|GO:0007169 extracellular matrix|signaling|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|ion binding|regulation of signaling|protein binding|heparin binding|growth factor binding|anion binding|regulation of cellular response to growth factor stimulus|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|regulation of vascular permeability|positive regulation of signal transduction|glycosaminoglycan binding|response to organic substance|circulatory system process|response to fibroblast growth factor|regulation of fibroblast growth factor receptor signaling pathway|cell surface receptor signaling pathway|positive regulation of vascular permeability|cellular response to fibroblast growth factor stimulus|response to growth factor|cellular response to organic substance|positive regulation of fibroblast growth factor receptor signaling pathway|blood circulation|fibroblast growth factor binding|fibroblast growth factor receptor signaling pathway|cellular response to growth factor stimulus|enzyme linked receptor protein signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway - - - - 10:91906589-91909483 187 200 134 44 49 37 5.19756611014593 5.05204731466165 3.35797985166931 1.09575379036883 1.11743717222227 0.96379357405783 4.5358644254923 1.05899484554964 2.09868195224728 1.42801755052004e-11 4.25045223860671e-10 UP ENSG00000104884 ERCC2 excision repair cross-complementation group 2 [Source:HGNC Symbol;Acc:HGNC:3434] GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0002262|GO:0009893|GO:0016787|GO:0009058|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0016032|GO:0047485|GO:0051726|GO:0007049|GO:0006281|GO:0009791|GO:0006725|GO:0009888|GO:0048468|GO:0008022|GO:0009314|GO:0022402|GO:1901360|GO:0051536|GO:0007275|GO:0003676|GO:0048513|GO:0034101|GO:0034641|GO:0043168|GO:0043062|GO:0044281|GO:0001882|GO:0016772|GO:0048524|GO:0031325|GO:0046483|GO:0033554|GO:0016817|GO:0022607|GO:0051098|GO:0043231|GO:0043169|GO:0001942|GO:0000439|GO:0005737|GO:0005667|GO:0035264|GO:0042592|GO:0006979|GO:0006139|GO:0000307|GO:0001503|GO:0008219|GO:0071817|GO:0001666|GO:0007059|GO:0000166|GO:0051301|GO:0048869|GO:0044249|GO:0019538|GO:0050792|GO:0031323|GO:0006996|GO:0007568|GO:0051276|GO:0003677|GO:0019908|GO:0051539|GO:0010468|GO:0034645|GO:0030218|GO:0051101|GO:0046872|GO:0035639|GO:1903047|GO:0044798|GO:0043412|GO:0030097|GO:0007417|GO:0021782|GO:0010629|GO:0022405|GO:0051252|GO:0021510|GO:0001883|GO:0044770|GO:0048820|GO:0031214|GO:0009790|GO:0010628|GO:0016818|GO:0036211|GO:0000278|GO:0048872|GO:0019083|GO:0032549|GO:0031981|GO:0007346|GO:1990234|GO:0010564|GO:0051099|GO:0005654|GO:0006259|GO:0016301|GO:0043588|GO:0012501|GO:0060429|GO:0006796|GO:0044267|GO:0032288|GO:1903902|GO:0010467|GO:0007399|GO:0019058|GO:0017076|GO:0030198|GO:0031328|GO:0040016|GO:0009059|GO:0030154|GO:0048469|GO:0006289|GO:0016070|GO:0016773|GO:0005856|GO:0010557|GO:0005634|GO:0009416|GO:0030282|GO:0005819|GO:0006974|GO:0008366|GO:0042633|GO:0030182|GO:0045814|GO:0045893|GO:0048863|GO:0019907|GO:0009792|GO:0010001|GO:0009411|GO:0006396|GO:0030855|GO:0046782|GO:0032774|GO:0005524|GO:0044772|GO:2001141|GO:0014003|GO:0005675|GO:0030554|GO:0016310|GO:0043388|GO:0008544|GO:0006283|GO:1901990|GO:0040029|GO:0070911|GO:0015630|GO:0016071|GO:0048709|GO:0032289|GO:0033683|GO:0004672|GO:0002244|GO:1901987|GO:0048821|GO:0090575|GO:0090305|GO:0042552|GO:0043249|GO:0030099|GO:0050434|GO:0022008|GO:0006464|GO:0016591|GO:0071103|GO:0016462|GO:0006351|GO:0006915|GO:0006355|GO:0060218|GO:0098773|GO:0022010|GO:0045944|GO:0006366|GO:0006352|GO:0006357|GO:1902911|GO:0006360|GO:0006468|GO:0048699|GO:0032392|GO:1903506|GO:0017111|GO:0006354|GO:0006397|GO:0035315|GO:0042063|GO:0004674|GO:0009650|GO:0043009|GO:0006353|GO:0009913|GO:0006367|GO:0016887|GO:0006368|GO:1902554|GO:0006361|GO:0006370|GO:0006362|GO:0006363|GO:0032508|GO:0008353|GO:0001701|GO:0004386|GO:0009452|GO:0003678|GO:0042623|GO:0008026|GO:0043139|GO:0008094|GO:0004003 developmental process|growth|macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|myeloid cell homeostasis|positive regulation of metabolic process|hydrolase activity|biosynthetic process|developmental growth|intracellular|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|viral process|protein N-terminus binding|regulation of cell cycle|cell cycle|DNA repair|post-embryonic development|cellular aromatic compound metabolic process|tissue development|cell development|protein C-terminus binding|response to radiation|cell cycle process|organic cyclic compound metabolic process|iron-sulfur cluster binding|multicellular organism development|nucleic acid binding|animal organ development|erythrocyte homeostasis|cellular nitrogen compound metabolic process|anion binding|extracellular structure organization|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|cellular component assembly|regulation of binding|intracellular membrane-bounded organelle|cation binding|hair follicle development|core TFIIH complex|cytoplasm|transcription factor complex|multicellular organism growth|homeostatic process|response to oxidative stress|nucleobase-containing compound metabolic process|cyclin-dependent protein kinase holoenzyme complex|ossification|cell death|MMXD complex|response to hypoxia|chromosome segregation|nucleotide binding|cell division|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of viral process|regulation of cellular metabolic process|organelle organization|aging|chromosome organization|DNA binding|nuclear cyclin-dependent protein kinase holoenzyme complex|4 iron, 4 sulfur cluster binding|regulation of gene expression|cellular macromolecule biosynthetic process|erythrocyte differentiation|regulation of DNA binding|metal ion binding|purine ribonucleoside triphosphate binding|mitotic cell cycle process|nuclear transcription factor complex|macromolecule modification|hemopoiesis|central nervous system development|glial cell development|negative regulation of gene expression|hair cycle process|regulation of RNA metabolic process|spinal cord development|purine nucleoside binding|cell cycle phase transition|hair follicle maturation|biomineral tissue development|embryo development|positive regulation of gene expression|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|mitotic cell cycle|homeostasis of number of cells|viral transcription|ribonucleoside binding|nuclear lumen|regulation of mitotic cell cycle|transferase complex|regulation of cell cycle process|positive regulation of binding|nucleoplasm|DNA metabolic process|kinase activity|skin development|programmed cell death|epithelium development|phosphate-containing compound metabolic process|cellular protein metabolic process|myelin assembly|positive regulation of viral life cycle|gene expression|nervous system development|viral life cycle|purine nucleotide binding|extracellular matrix organization|positive regulation of cellular biosynthetic process|embryonic cleavage|macromolecule biosynthetic process|cell differentiation|cell maturation|nucleotide-excision repair|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|bone mineralization|spindle|cellular response to DNA damage stimulus|axon ensheathment|hair cycle|neuron differentiation|negative regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|stem cell differentiation|cyclin-dependent protein kinase activating kinase holoenzyme complex|embryo development ending in birth or egg hatching|glial cell differentiation|response to UV|RNA processing|epithelial cell differentiation|regulation of viral transcription|RNA biosynthetic process|ATP binding|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|oligodendrocyte development|holo TFIIH complex|adenyl nucleotide binding|phosphorylation|positive regulation of DNA binding|epidermis development|transcription-coupled nucleotide-excision repair|regulation of mitotic cell cycle phase transition|regulation of gene expression, epigenetic|global genome nucleotide-excision repair|microtubule cytoskeleton|mRNA metabolic process|oligodendrocyte differentiation|central nervous system myelin formation|nucleotide-excision repair, DNA incision|protein kinase activity|hematopoietic progenitor cell differentiation|regulation of cell cycle phase transition|erythrocyte development|RNA polymerase II transcription factor complex|nucleic acid phosphodiester bond hydrolysis|myelination|erythrocyte maturation|myeloid cell differentiation|positive regulation of viral transcription|neurogenesis|cellular protein modification process|DNA-directed RNA polymerase II, holoenzyme|DNA conformation change|pyrophosphatase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|hematopoietic stem cell differentiation|skin epidermis development|central nervous system myelination|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|protein kinase complex|transcription from RNA polymerase I promoter|protein phosphorylation|generation of neurons|DNA geometric change|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|DNA-templated transcription, elongation|mRNA processing|hair cell differentiation|gliogenesis|protein serine/threonine kinase activity|UV protection|chordate embryonic development|DNA-templated transcription, termination|epidermal cell differentiation|transcription initiation from RNA polymerase II promoter|ATPase activity|transcription elongation from RNA polymerase II promoter|serine/threonine protein kinase complex|transcription initiation from RNA polymerase I promoter|7-methylguanosine mRNA capping|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|DNA duplex unwinding|RNA polymerase II carboxy-terminal domain kinase activity|in utero embryonic development|helicase activity|7-methylguanosine RNA capping|DNA helicase activity|ATPase activity, coupled|ATP-dependent helicase activity|5'-3' DNA helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity K10844 DNA excision repair protein ERCC-2[3.6.4.12] hsa03420|hsa03022 Nucleotide excision repair - Homo sapiens (human)|Basal transcription factors - Homo sapiens (human) 19:45349837-45370918 101 82 173 405 524 515 0.807830652757079 0.596060467037958 1.247546656246 2.90234958275729 3.43871504176185 3.86040936129572 0.883812592013679 3.40049132860495 -1.9439308218937 1.44763575623794e-11 4.3045535723832e-10 DOWN ENSG00000171840 NINJ2 ninjurin 2 [Source:HGNC Symbol;Acc:HGNC:7825] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0050896|GO:0005488|GO:0006950|GO:0007155|GO:0071944|GO:0031224|GO:0048589|GO:0005515|GO:0005886|GO:0048856|GO:0016337|GO:0009888|GO:0007275|GO:0042246|GO:0098609|GO:0005887|GO:0009611|GO:0031226|GO:0016021|GO:0042060|GO:0007158|GO:0007399 developmental process|growth|cell|membrane|response to stimulus|binding|response to stress|cell adhesion|cell periphery|intrinsic component of membrane|developmental growth|protein binding|plasma membrane|anatomical structure development|single organismal cell-cell adhesion|tissue development|multicellular organism development|tissue regeneration|cell-cell adhesion|integral component of plasma membrane|response to wounding|intrinsic component of plasma membrane|integral component of membrane|wound healing|neuron cell-cell adhesion|nervous system development - - - - 12:564296-663779 7 5 6 61 73 38 0.156947090685136 0.101891263091353 0.121289480817839 1.22537930696888 1.34288870105889 0.798459711998382 0.126709278198109 1.12224257334205 -3.146790475178 1.4494293526121e-11 4.30559839730165e-10 DOWN ENSG00000145041 VPRBP Vpr (HIV-1) binding protein [Source:HGNC Symbol;Acc:HGNC:30911] GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0040008|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0016032|GO:0006725|GO:1901360|GO:0007275|GO:0016570|GO:0048513|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0046483|GO:0043231|GO:0005737|GO:0001775|GO:0009890|GO:0006139|GO:0046649|GO:0035212|GO:0000166|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0008180|GO:0006996|GO:0051276|GO:0005730|GO:0042113|GO:0010468|GO:0034645|GO:0035639|GO:0043412|GO:0030097|GO:0030098|GO:0010629|GO:0016572|GO:0051252|GO:0006325|GO:0001883|GO:0033151|GO:0036211|GO:0032549|GO:0031981|GO:0006259|GO:0016301|GO:0006796|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0030154|GO:0016070|GO:0016773|GO:0005634|GO:0002521|GO:0030183|GO:0045892|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0016310|GO:1902679|GO:0006310|GO:0004672|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0035173|GO:0006468|GO:1903506|GO:0018193|GO:0016444|GO:0004674|GO:0000122|GO:1990245|GO:0032446|GO:0018107|GO:0016567|GO:1990244 developmental process|growth|macromolecular complex|immune system process|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|regulation of growth|biosynthetic process|intracellular|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|histone modification|animal organ development|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cell activation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|lymphocyte activation|cell competition in a multicellular organism|nucleotide binding|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|COP9 signalosome|organelle organization|chromosome organization|nucleolus|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|macromolecule modification|hemopoiesis|lymphocyte differentiation|negative regulation of gene expression|histone phosphorylation|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|V(D)J recombination|protein modification process|ribonucleoside binding|nuclear lumen|DNA metabolic process|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|leukocyte differentiation|B cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|negative regulation of RNA biosynthetic process|DNA recombination|protein kinase activity|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|histone kinase activity|protein phosphorylation|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|somatic cell DNA recombination|protein serine/threonine kinase activity|negative regulation of transcription from RNA polymerase II promoter|histone H2A-T120 phosphorylation|protein modification by small protein conjugation|peptidyl-threonine phosphorylation|protein ubiquitination|histone kinase activity (H2A-T120 specific) - - - - 3:51395867-51500002 251 237 331 752 862 787 2.05759097947047 1.76568791486816 2.446397942972 5.52332810349271 5.7977611584087 6.04629037780177 2.08989227910354 5.78912654656773 -1.46991711099116 1.46462043606829e-11 4.34639945311955e-10 DOWN ENSG00000182752 PAPPA pregnancy-associated plasma protein A, pappalysin 1 [Source:HGNC Symbol;Acc:HGNC:8602] GO:0000003|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0043169|GO:0008233|GO:0007565|GO:0019538|GO:0046872|GO:0006508|GO:0044267|GO:0008237|GO:0004175|GO:0046914|GO:0008270|GO:0004222 reproduction|cellular process|extracellular region|reproductive process|metabolic process|binding|catalytic activity|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|cation binding|peptidase activity|female pregnancy|protein metabolic process|metal ion binding|proteolysis|cellular protein metabolic process|metallopeptidase activity|endopeptidase activity|transition metal ion binding|zinc ion binding|metalloendopeptidase activity - - - - 9:116153804-116402322 17 25 44 142 153 137 0.102620216811167 0.13715761876042 0.239474956434686 0.768028714721821 0.757794658762274 0.775070437340315 0.159750930668758 0.766964603608137 -2.26333566107833 1.5122095714392e-11 4.48316827663811e-10 DOWN ENSG00000090530 P3H2 prolyl 3-hydroxylase 2 [Source:HGNC Symbol;Acc:HGNC:19317] GO:0031012|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0005604|GO:0036094|GO:0048523|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0005578|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0030246|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0048029|GO:0042127|GO:0051213|GO:0043168|GO:0043062|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0043177|GO:0019842|GO:0044236|GO:0005783|GO:0008285|GO:0019538|GO:0005794|GO:0055114|GO:0044259|GO:0046872|GO:0043412|GO:0036211|GO:0031418|GO:0016706|GO:0044267|GO:0031406|GO:0005788|GO:0030198|GO:0046914|GO:0006464|GO:0031543|GO:0032963|GO:0005506|GO:0018126|GO:0031544|GO:0018193|GO:0019511|GO:0018208|GO:0019797 extracellular matrix|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|basement membrane|small molecule binding|negative regulation of cellular process|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|carbohydrate binding|membrane-bounded organelle|intracellular|protein binding|endomembrane system|monosaccharide binding|regulation of cell proliferation|dioxygenase activity|anion binding|extracellular structure organization|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|organic acid binding|vitamin binding|multicellular organism metabolic process|endoplasmic reticulum|negative regulation of cell proliferation|protein metabolic process|Golgi apparatus|oxidation-reduction process|multicellular organismal macromolecule metabolic process|metal ion binding|macromolecule modification|protein modification process|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|cellular protein metabolic process|carboxylic acid binding|endoplasmic reticulum lumen|extracellular matrix organization|transition metal ion binding|cellular protein modification process|peptidyl-proline dioxygenase activity|collagen metabolic process|iron ion binding|protein hydroxylation|peptidyl-proline 3-dioxygenase activity|peptidyl-amino acid modification|peptidyl-proline hydroxylation|peptidyl-proline modification|procollagen-proline 3-dioxygenase activity - - - - 3:189956728-190122437 255 275 564 1342 1167 1409 2.14379448700301 2.1011455308298 4.27500437950964 10.1086544899965 8.04974465800165 11.1015356569731 2.83998146578082 9.75331160165708 -1.78001063465086 1.56550998648986e-11 4.63198564288091e-10 DOWN ENSG00000196756 SNHG17 small nucleolar RNA host gene 17 [Source:HGNC Symbol;Acc:HGNC:48600] - - - - - - 20:38420588-38435353 876 833 683 293 291 155 9.75987562819266 8.43462181537856 6.8608140125876 2.92486701697718 2.66012506826743 1.61845327375233 8.35177048538627 2.40114845299898 1.79835746367183 1.56509768636375e-11 4.63198564288091e-10 UP ENSG00000198455 ZXDB zinc finger, X-linked, duplicated B [Source:HGNC Symbol;Acc:HGNC:13199] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:57591652-57597545 1252 1441 1574 601 715 586 15.0258786884856 15.7173555429102 17.0315661107959 6.46260230630484 7.04060168770624 6.5911626140347 15.9249334473972 6.69812220268193 1.24945874087597 1.56838667183703e-11 4.63590254465571e-10 UP ENSG00000091009 RBM27 RNA binding motif protein 27 [Source:HGNC Symbol;Acc:HGNC:29243] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0000166|GO:0046872|GO:0003723|GO:0031981|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0016604|GO:0016071|GO:0044822|GO:0016607|GO:0006397 cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|nucleotide binding|metal ion binding|RNA binding|nuclear lumen|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|nuclear body|mRNA metabolic process|poly(A) RNA binding|nuclear speck|mRNA processing - - - - 5:146203600-146289132 390 504 540 1328 1595 1199 3.99585001561608 4.6930563582223 4.9883082777559 12.1910415788741 13.4082938164797 11.5131260264254 4.55907155053143 12.3708204739264 -1.44012923152185 1.58378306585555e-11 4.67678136973803e-10 DOWN ENSG00000102890 ELMO3 engulfment and cell motility 3 [Source:HGNC Symbol;Acc:HGNC:17289] GO:0040011|GO:0005623|GO:0009987|GO:0005488|GO:0048870|GO:0005622|GO:0005515|GO:0006810|GO:0005737|GO:0006928|GO:0019904|GO:0016477|GO:0008219|GO:0016192|GO:0006909|GO:0017124|GO:0012501|GO:0006897|GO:0006915 locomotion|cell|cellular process|binding|cell motility|intracellular|protein binding|transport|cytoplasm|movement of cell or subcellular component|protein domain specific binding|cell migration|cell death|vesicle-mediated transport|phagocytosis|SH3 domain binding|programmed cell death|endocytosis|apoptotic process K19241 engulfment and cell motility protein 3[-] hsa05100|hsa05131 Bacterial invasion of epithelial cells - Homo sapiens (human)|Shigellosis - Homo sapiens (human) 16:67199111-67204029 320 324 560 1141 1214 1378 7.13837916070488 6.56861743097399 11.2629374459815 22.8051353747192 22.219602908203 28.8089723622867 8.32331134588679 24.6112368817363 -1.56408765541319 1.5882671800157e-11 4.68349192376511e-10 DOWN ENSG00000198887 SMC5 structural maintenance of chromosomes 5 [Source:HGNC Symbol;Acc:HGNC:20465] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:0051130|GO:1901360|GO:0051302|GO:0034641|GO:0043168|GO:0001882|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0030915|GO:0043231|GO:0000723|GO:0042592|GO:0045787|GO:0006139|GO:0051983|GO:0007059|GO:0000166|GO:0051781|GO:0051301|GO:0048869|GO:0051984|GO:0019538|GO:0031323|GO:0006996|GO:0007568|GO:0051276|GO:0032268|GO:0045732|GO:0000819|GO:0090068|GO:0000725|GO:0035639|GO:1903047|GO:0043412|GO:0030163|GO:0051304|GO:0001883|GO:0000722|GO:0044770|GO:0044265|GO:0006302|GO:0036211|GO:0000278|GO:0032549|GO:0035861|GO:0007569|GO:0031981|GO:0007062|GO:0007346|GO:0010564|GO:0051247|GO:0006508|GO:0005654|GO:0006259|GO:0005694|GO:0032270|GO:0033043|GO:0044267|GO:0042176|GO:0007067|GO:1901970|GO:0017076|GO:0045876|GO:0051246|GO:0045931|GO:0005634|GO:0090398|GO:0006974|GO:0010638|GO:2001252|GO:0044257|GO:0000724|GO:0007063|GO:0032200|GO:0000781|GO:0010498|GO:0000803|GO:0007088|GO:1903364|GO:0000793|GO:0005524|GO:0044772|GO:0030162|GO:0007064|GO:0045862|GO:0030554|GO:0033044|GO:0016604|GO:1901990|GO:1901989|GO:0051603|GO:1901992|GO:0006310|GO:0000070|GO:0045840|GO:0051306|GO:1901987|GO:0045842|GO:0007091|GO:0006464|GO:0034088|GO:0030071|GO:1903052|GO:0010965|GO:0019941|GO:1901800|GO:0018193|GO:0006312|GO:0016605|GO:0035061|GO:0043687|GO:0034184|GO:0061136|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0032436|GO:0018205|GO:0016925 developmental process|macromolecular complex|cell|cellular process|metabolic process|cell junction|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell division|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|Smc5-Smc6 complex|intracellular membrane-bounded organelle|telomere maintenance|homeostatic process|positive regulation of cell cycle|nucleobase-containing compound metabolic process|regulation of chromosome segregation|chromosome segregation|nucleotide binding|positive regulation of cell division|cell division|cellular developmental process|positive regulation of chromosome segregation|protein metabolic process|regulation of cellular metabolic process|organelle organization|aging|chromosome organization|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|sister chromatid segregation|positive regulation of cell cycle process|recombinational repair|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|protein catabolic process|chromosome separation|purine nucleoside binding|telomere maintenance via recombination|cell cycle phase transition|cellular macromolecule catabolic process|double-strand break repair|protein modification process|mitotic cell cycle|ribonucleoside binding|site of double-strand break|cell aging|nuclear lumen|sister chromatid cohesion|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|proteolysis|nucleoplasm|DNA metabolic process|chromosome|positive regulation of cellular protein metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|mitotic nuclear division|positive regulation of mitotic sister chromatid separation|purine nucleotide binding|positive regulation of sister chromatid cohesion|regulation of protein metabolic process|positive regulation of mitotic cell cycle|nucleus|cellular senescence|cellular response to DNA damage stimulus|positive regulation of organelle organization|positive regulation of chromosome organization|cellular protein catabolic process|double-strand break repair via homologous recombination|regulation of sister chromatid cohesion|telomere organization|chromosome, telomeric region|proteasomal protein catabolic process|sex chromosome|regulation of mitotic nuclear division|positive regulation of cellular protein catabolic process|condensed chromosome|ATP binding|mitotic cell cycle phase transition|regulation of proteolysis|mitotic sister chromatid cohesion|positive regulation of proteolysis|adenyl nucleotide binding|regulation of chromosome organization|nuclear body|regulation of mitotic cell cycle phase transition|positive regulation of cell cycle phase transition|proteolysis involved in cellular protein catabolic process|positive regulation of mitotic cell cycle phase transition|DNA recombination|mitotic sister chromatid segregation|positive regulation of mitotic nuclear division|mitotic sister chromatid separation|regulation of cell cycle phase transition|positive regulation of mitotic metaphase/anaphase transition|metaphase/anaphase transition of mitotic cell cycle|cellular protein modification process|maintenance of mitotic sister chromatid cohesion|regulation of mitotic metaphase/anaphase transition|positive regulation of proteolysis involved in cellular protein catabolic process|regulation of mitotic sister chromatid separation|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|peptidyl-amino acid modification|mitotic recombination|PML body|interchromatin granule|post-translational protein modification|positive regulation of maintenance of mitotic sister chromatid cohesion|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|peptidyl-lysine modification|protein sumoylation - - - - 9:70258962-70354888 237 251 479 1043 1148 1014 2.39186994145063 2.30220334519964 4.35852750754142 9.43130506357726 9.50603726624549 9.59084146426799 3.0175335980639 9.50939459803025 -1.65598366245833 1.58919317973272e-11 4.68349192376511e-10 DOWN ENSG00000115947 ORC4 origin recognition complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:8490] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0006725|GO:0000808|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0000166|GO:0044249|GO:0005730|GO:0003677|GO:0034645|GO:0035639|GO:1903047|GO:0005664|GO:0001883|GO:0044770|GO:0000278|GO:0032549|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0017076|GO:0009059|GO:0005856|GO:0005634|GO:0015629|GO:0006270|GO:0006260|GO:0000781|GO:0005524|GO:0044772|GO:0043565|GO:0030554|GO:0003690|GO:0000784|GO:0006261|GO:0000082|GO:0003688 macromolecular complex|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|cell cycle|cellular aromatic compound metabolic process|origin recognition complex|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|nucleolus|DNA binding|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|mitotic cell cycle process|nuclear origin of replication recognition complex|purine nucleoside binding|cell cycle phase transition|mitotic cell cycle|ribonucleoside binding|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|purine nucleotide binding|macromolecule biosynthetic process|cytoskeleton|nucleus|actin cytoskeleton|DNA replication initiation|DNA replication|chromosome, telomeric region|ATP binding|mitotic cell cycle phase transition|sequence-specific DNA binding|adenyl nucleotide binding|double-stranded DNA binding|nuclear chromosome, telomeric region|DNA-dependent DNA replication|G1/S transition of mitotic cell cycle|DNA replication origin binding K02606 origin recognition complex subunit 4[-] hsa04110 Cell cycle - Homo sapiens (human) 2:147930397-148021604 165 212 275 706 752 598 0.728746322709345 0.85095579675092 1.09506308908572 2.79379015380471 2.72506966947919 2.47526738418793 0.891588402848662 2.66470906915728 -1.57952827299556 1.64193947093712e-11 4.83416774806281e-10 DOWN ENSG00000183423 LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 [Source:HGNC Symbol;Acc:HGNC:24783] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0042175|GO:0023051|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0050877|GO:0090287|GO:0043231|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0005783|GO:0016021|GO:0010033|GO:0071774|GO:0040036|GO:0007166|GO:0007600|GO:0044344|GO:0070848|GO:0071310|GO:0050953|GO:0008543|GO:0071363|GO:0007167|GO:0007601|GO:0007169 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|regulation of signaling|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|neurological system process|regulation of cellular response to growth factor stimulus|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|endoplasmic reticulum|integral component of membrane|response to organic substance|response to fibroblast growth factor|regulation of fibroblast growth factor receptor signaling pathway|cell surface receptor signaling pathway|sensory perception|cellular response to fibroblast growth factor stimulus|response to growth factor|cellular response to organic substance|sensory perception of light stimulus|fibroblast growth factor receptor signaling pathway|cellular response to growth factor stimulus|enzyme linked receptor protein signaling pathway|visual perception|transmembrane receptor protein tyrosine kinase signaling pathway - - - - 4:109848202-109872315 117 80 38 9 6 5 1.89386528607649 1.17688424858708 0.554576482270338 0.130525312209494 0.0796807783659759 0.0758579504894719 1.20844200564464 0.0953546803549806 3.66370067514116 1.702146774608e-11 5.00649160681254e-10 UP ENSG00000125850 OVOL2 ovo-like zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:15804] GO:0040011|GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0051726|GO:0042127|GO:0007049|GO:0048565|GO:0060674|GO:0001890|GO:0010719|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0045684|GO:0035295|GO:1901360|GO:0001568|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0001842|GO:0003157|GO:0031325|GO:0046483|GO:0051128|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0000981|GO:0007389|GO:0006928|GO:0009887|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0050673|GO:0009890|GO:0060214|GO:0003682|GO:0010646|GO:0006139|GO:0001892|GO:0001525|GO:0007154|GO:0035148|GO:0061383|GO:0016477|GO:0007165|GO:0009968|GO:0008285|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0060711|GO:0072089|GO:0003205|GO:0000902|GO:0003677|GO:0045682|GO:0003143|GO:0010468|GO:0034645|GO:0055123|GO:0046872|GO:0007166|GO:2000736|GO:0002009|GO:0001944|GO:0061458|GO:0072358|GO:0060347|GO:0010629|GO:0045605|GO:0051252|GO:0035050|GO:0010717|GO:0003007|GO:0010721|GO:0000904|GO:0009790|GO:0010628|GO:0001667|GO:0072175|GO:0030856|GO:2000647|GO:0003002|GO:0060485|GO:0016331|GO:0061371|GO:0008593|GO:0022604|GO:0030858|GO:0050678|GO:0043588|GO:0001841|GO:0060429|GO:0048864|GO:0010467|GO:0048562|GO:0007399|GO:0060562|GO:0045606|GO:2000737|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0048566|GO:0048546|GO:0016070|GO:0060716|GO:0072359|GO:0043616|GO:0010557|GO:0030857|GO:0005634|GO:0061384|GO:0045746|GO:0072091|GO:0003160|GO:0003158|GO:0001755|GO:0010837|GO:0000975|GO:0060571|GO:0045893|GO:0048863|GO:0009792|GO:0030855|GO:0010769|GO:0045892|GO:0032774|GO:0030216|GO:2001141|GO:0001838|GO:0014031|GO:1902679|GO:0008544|GO:0045604|GO:0048557|GO:0001947|GO:0045617|GO:0009855|GO:0009953|GO:0045618|GO:0048762|GO:0007219|GO:0001837|GO:0006351|GO:0006355|GO:0014033|GO:0045616|GO:0014032|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:0007368|GO:1903506|GO:0044212|GO:0043009|GO:0010944|GO:0009913|GO:0001701 locomotion|developmental process|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|regulation of cell cycle|regulation of cell proliferation|cell cycle|digestive tract development|placenta blood vessel development|placenta development|negative regulation of epithelial to mesenchymal transition|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|positive regulation of epidermis development|tube development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|neural fold formation|endocardium development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|movement of cell or subcellular component|organ morphogenesis|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|epithelial cell proliferation|negative regulation of biosynthetic process|endocardium formation|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|angiogenesis|cell communication|tube formation|trabecula morphogenesis|cell migration|signal transduction|negative regulation of signal transduction|negative regulation of cell proliferation|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|labyrinthine layer development|stem cell proliferation|cardiac chamber development|cell morphogenesis|DNA binding|regulation of epidermis development|embryonic heart tube morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|digestive system development|metal ion binding|cell surface receptor signaling pathway|regulation of stem cell differentiation|morphogenesis of an epithelium|vasculature development|reproductive system development|cardiovascular system development|heart trabecula formation|negative regulation of gene expression|negative regulation of epidermal cell differentiation|regulation of RNA metabolic process|embryonic heart tube development|regulation of epithelial to mesenchymal transition|heart morphogenesis|negative regulation of cell development|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|ameboidal-type cell migration|epithelial tube formation|regulation of epithelial cell differentiation|negative regulation of stem cell proliferation|regionalization|mesenchyme development|morphogenesis of embryonic epithelium|determination of heart left/right asymmetry|regulation of Notch signaling pathway|regulation of cell morphogenesis|positive regulation of epithelial cell differentiation|regulation of epithelial cell proliferation|skin development|neural tube formation|epithelium development|stem cell development|gene expression|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|positive regulation of epidermal cell differentiation|negative regulation of stem cell differentiation|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|embryonic digestive tract development|digestive tract morphogenesis|RNA metabolic process|labyrinthine layer blood vessel development|circulatory system development|keratinocyte proliferation|positive regulation of macromolecule biosynthetic process|negative regulation of epithelial cell differentiation|nucleus|heart trabecula morphogenesis|negative regulation of Notch signaling pathway|regulation of stem cell proliferation|endocardium morphogenesis|endothelium development|neural crest cell migration|regulation of keratinocyte proliferation|regulatory region DNA binding|morphogenesis of an epithelial fold|positive regulation of transcription, DNA-templated|stem cell differentiation|embryo development ending in birth or egg hatching|epithelial cell differentiation|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|keratinocyte differentiation|regulation of RNA biosynthetic process|embryonic epithelial tube formation|mesenchymal cell development|negative regulation of RNA biosynthetic process|epidermis development|regulation of epidermal cell differentiation|embryonic digestive tract morphogenesis|heart looping|negative regulation of keratinocyte differentiation|determination of bilateral symmetry|dorsal/ventral pattern formation|positive regulation of keratinocyte differentiation|mesenchymal cell differentiation|Notch signaling pathway|epithelial to mesenchymal transition|transcription, DNA-templated|regulation of transcription, DNA-templated|neural crest cell differentiation|regulation of keratinocyte differentiation|neural crest cell development|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|determination of left/right symmetry|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|negative regulation of transcription by competitive promoter binding|epidermal cell differentiation|in utero embryonic development - - - - 20:17956979-18059188 43 57 84 274 283 212 1.01899794276159 1.22760691563311 1.79471452965376 5.8176805863867 5.50244643276445 4.70832192255822 1.34710646268282 5.34281631390312 -1.98773654572335 1.72638015827511e-11 5.07277098869539e-10 DOWN ENSG00000108187 PBLD phenazine biosynthesis-like protein domain containing [Source:HGNC Symbol;Acc:HGNC:23301] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0040013|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:1903828|GO:0016853|GO:0023057|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:0042127|GO:1900181|GO:0010719|GO:0045595|GO:0009888|GO:0048468|GO:0006810|GO:0007275|GO:0010632|GO:0045596|GO:0048513|GO:0031982|GO:0051128|GO:0090287|GO:0005737|GO:0032880|GO:0071559|GO:0006928|GO:0042592|GO:0009966|GO:0050673|GO:0045184|GO:0048871|GO:0032387|GO:0010646|GO:0090288|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0070062|GO:0051649|GO:0007586|GO:0051271|GO:0008285|GO:0090317|GO:0048869|GO:2000145|GO:0010633|GO:0019538|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:2000146|GO:0032268|GO:0000902|GO:0090132|GO:0042308|GO:0090101|GO:0007166|GO:2000736|GO:0043412|GO:0072594|GO:0030277|GO:0001894|GO:0032386|GO:0010717|GO:0010721|GO:0051223|GO:0015031|GO:0000904|GO:0030334|GO:0001667|GO:0036211|GO:0032269|GO:0071560|GO:0070201|GO:0046907|GO:0060485|GO:0070848|GO:0022604|GO:0050678|GO:0050680|GO:0030336|GO:0034613|GO:0006796|GO:0044267|GO:0051174|GO:0048864|GO:0017038|GO:0071310|GO:2000737|GO:0051246|GO:0030154|GO:1903827|GO:0006606|GO:1904589|GO:0048863|GO:0060393|GO:0033365|GO:0033157|GO:0051169|GO:0010769|GO:0060390|GO:0014031|GO:0071363|GO:0016310|GO:0006605|GO:0007179|GO:0030512|GO:0016482|GO:0006886|GO:0007167|GO:0060394|GO:0010631|GO:0060392|GO:0048762|GO:0042306|GO:1900180|GO:0006464|GO:0007184|GO:0001837|GO:0017015|GO:0010669|GO:1903533|GO:0006913|GO:0006468|GO:0042325|GO:0001932|GO:0042326|GO:0007178|GO:0001933|GO:0034504|GO:0046822|GO:0051170|GO:0060389 locomotion|developmental process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of cellular protein localization|isomerase activity|negative regulation of signaling|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|regulation of cell proliferation|negative regulation of protein localization to nucleus|negative regulation of epithelial to mesenchymal transition|regulation of cell differentiation|tissue development|cell development|transport|multicellular organism development|regulation of epithelial cell migration|negative regulation of cell differentiation|animal organ development|vesicle|regulation of cellular component organization|regulation of cellular response to growth factor stimulus|cytoplasm|regulation of protein localization|response to transforming growth factor beta|movement of cell or subcellular component|homeostatic process|regulation of signal transduction|epithelial cell proliferation|establishment of protein localization|multicellular organismal homeostasis|negative regulation of intracellular transport|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|digestion|negative regulation of cellular component movement|negative regulation of cell proliferation|negative regulation of intracellular protein transport|cellular developmental process|regulation of cell motility|negative regulation of epithelial cell migration|protein metabolic process|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|regulation of cellular protein metabolic process|cell morphogenesis|epithelium migration|negative regulation of protein import into nucleus|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|regulation of stem cell differentiation|macromolecule modification|establishment of protein localization to organelle|maintenance of gastrointestinal epithelium|tissue homeostasis|regulation of intracellular transport|regulation of epithelial to mesenchymal transition|negative regulation of cell development|regulation of protein transport|protein transport|cell morphogenesis involved in differentiation|regulation of cell migration|ameboidal-type cell migration|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|regulation of establishment of protein localization|intracellular transport|mesenchyme development|response to growth factor|regulation of cell morphogenesis|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of cell migration|cellular protein localization|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|protein import|cellular response to organic substance|negative regulation of stem cell differentiation|regulation of protein metabolic process|cell differentiation|regulation of cellular protein localization|protein import into nucleus|regulation of protein import|stem cell differentiation|regulation of pathway-restricted SMAD protein phosphorylation|protein localization to organelle|regulation of intracellular protein transport|nuclear transport|regulation of cell morphogenesis involved in differentiation|regulation of SMAD protein import into nucleus|mesenchymal cell development|cellular response to growth factor stimulus|phosphorylation|protein targeting|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|cytosolic transport|intracellular protein transport|enzyme linked receptor protein signaling pathway|negative regulation of pathway-restricted SMAD protein phosphorylation|epithelial cell migration|negative regulation of SMAD protein import into nucleus|mesenchymal cell differentiation|regulation of protein import into nucleus|regulation of protein localization to nucleus|cellular protein modification process|SMAD protein import into nucleus|epithelial to mesenchymal transition|regulation of transforming growth factor beta receptor signaling pathway|epithelial structure maintenance|regulation of protein targeting|nucleocytoplasmic transport|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import|pathway-restricted SMAD protein phosphorylation - - - - 10:68282660-68333049 34 28 22 156 165 120 0.30889720808315 0.231189886747232 0.180201694782168 1.26985517796121 1.22993911323451 1.02174116103671 0.240096263204183 1.17384515074414 -2.28955725094807 1.74876652999963e-11 5.13349813044335e-10 DOWN ENSG00000135931 ARMC9 armadillo repeat containing 9 [Source:HGNC Symbol;Acc:HGNC:20730] GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0005515|GO:0031982|GO:0070062 extracellular region|binding|extracellular vesicle|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 2:231198546-231374837 96 114 179 438 493 441 0.457505446861708 0.493751427407796 0.769114797535532 1.87023187149585 1.92769597465222 1.96966115897019 0.573457223935012 1.92252966837275 -1.74524808196225 1.75636370603871e-11 5.15073497839681e-10 DOWN ENSG00000138640 FAM13A family with sequence similarity 13 member A [Source:HGNC Symbol;Acc:HGNC:19367] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0023051|GO:0009893|GO:0030234|GO:0005622|GO:0019222|GO:0008047|GO:0005737|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005829|GO:0005096|GO:0051345|GO:0030695|GO:0035556|GO:1902531|GO:0043087|GO:0043547|GO:0051056|GO:0007264 signaling|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of metabolic process|enzyme activator activity|cytoplasm|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cytosol|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 4:88725955-89111398 248 230 369 899 833 1413 0.71527027409817 0.602873663792954 0.959531398410943 2.32314666094304 1.97120618990045 3.81935637755985 0.759225112100689 2.70456974280111 -1.83279948399405 1.75992322141942e-11 5.15610871955401e-10 DOWN ENSG00000151665 PIGF phosphatidylinositol glycan anchor biosynthesis class F [Source:HGNC Symbol;Acc:HGNC:8962] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0016772|GO:0019637|GO:0043231|GO:0005737|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0019538|GO:0008654|GO:0034645|GO:0046486|GO:0043412|GO:0006643|GO:0036211|GO:0016780|GO:0042157|GO:0006796|GO:1901137|GO:0044267|GO:0008610|GO:0009059|GO:0006644|GO:0046474|GO:0009247|GO:0006664|GO:0042158|GO:0006464|GO:0006650|GO:0004307|GO:0016254|GO:0006506|GO:0046488|GO:0006661|GO:0006505|GO:0043687|GO:0006497|GO:0006501 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|protein metabolic process|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|glycerolipid metabolic process|macromolecule modification|membrane lipid metabolic process|protein modification process|phosphotransferase activity, for other substituted phosphate groups|lipoprotein metabolic process|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|lipid biosynthetic process|macromolecule biosynthetic process|phospholipid metabolic process|glycerophospholipid biosynthetic process|glycolipid biosynthetic process|glycolipid metabolic process|lipoprotein biosynthetic process|cellular protein modification process|glycerophospholipid metabolic process|ethanolaminephosphotransferase activity|preassembly of GPI anchor in ER membrane|GPI anchor biosynthetic process|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|GPI anchor metabolic process|post-translational protein modification|protein lipidation|C-terminal protein lipidation K05287 phosphatidylinositol glycan, class F [EC:2.7.-.-][-] hsa01100|hsa00563 Metabolic pathways - Homo sapiens (human)|Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human) 2:46580937-46617119 49 72 99 303 266 391 0.509572219469617 0.680488937032197 0.928235853688664 2.82324685366722 2.26964636611444 3.81078656471718 0.706099003396826 2.96789326149961 -2.07149682160153 1.78667446786725e-11 5.2293509376185e-10 DOWN ENSG00000157110 RBPMS RNA binding protein with multiple splicing [Source:HGNC Symbol;Acc:HGNC:19097] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:1903829|GO:0005515|GO:0019222|GO:0060341|GO:0003712|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0032880|GO:0051222|GO:0009966|GO:0045184|GO:0032388|GO:0010646|GO:0006139|GO:1900182|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0090316|GO:0000166|GO:0009967|GO:0044249|GO:0019538|GO:0031323|GO:0003713|GO:0032268|GO:0042307|GO:0010468|GO:0034645|GO:0003723|GO:0007166|GO:0043412|GO:0072594|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0036211|GO:0070201|GO:0046907|GO:0031981|GO:0051247|GO:0005654|GO:1904591|GO:0034613|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0017038|GO:0051246|GO:0009059|GO:1903827|GO:0016070|GO:0005634|GO:0006606|GO:1904589|GO:0060391|GO:0060393|GO:0033365|GO:0033157|GO:0031401|GO:0017069|GO:0051169|GO:0006396|GO:0032774|GO:0060390|GO:2001141|GO:0016310|GO:0006605|GO:0016482|GO:0006886|GO:0007167|GO:0010862|GO:0016071|GO:0044822|GO:0042306|GO:1900180|GO:0006464|GO:0007184|GO:0003727|GO:0006351|GO:0006355|GO:0046824|GO:1903533|GO:0006913|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0006397|GO:0001934|GO:0007178|GO:0008380|GO:0042327|GO:0034504|GO:0046822|GO:0000375|GO:0051170|GO:0060389|GO:0008143|GO:0000398 signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|positive regulation of cellular protein localization|protein binding|regulation of metabolic process|regulation of cellular localization|transcription cofactor activity|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|positive regulation of protein transport|regulation of signal transduction|establishment of protein localization|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of protein localization to nucleus|protein localization|cell communication|signal transduction|establishment of localization in cell|positive regulation of intracellular protein transport|nucleotide binding|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|transcription coactivator activity|regulation of cellular protein metabolic process|positive regulation of protein import into nucleus|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|cell surface receptor signaling pathway|macromolecule modification|establishment of protein localization to organelle|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|protein modification process|regulation of establishment of protein localization|intracellular transport|nuclear lumen|positive regulation of protein metabolic process|nucleoplasm|positive regulation of protein import|cellular protein localization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|protein import|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of cellular protein localization|RNA metabolic process|nucleus|protein import into nucleus|regulation of protein import|positive regulation of SMAD protein import into nucleus|regulation of pathway-restricted SMAD protein phosphorylation|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|snRNA binding|nuclear transport|RNA processing|RNA biosynthetic process|regulation of SMAD protein import into nucleus|regulation of RNA biosynthetic process|phosphorylation|protein targeting|cytosolic transport|intracellular protein transport|enzyme linked receptor protein signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|mRNA metabolic process|poly(A) RNA binding|regulation of protein import into nucleus|regulation of protein localization to nucleus|cellular protein modification process|SMAD protein import into nucleus|single-stranded RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of nucleocytoplasmic transport|regulation of protein targeting|nucleocytoplasmic transport|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|mRNA processing|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|RNA splicing|positive regulation of phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|RNA splicing, via transesterification reactions|nuclear import|pathway-restricted SMAD protein phosphorylation|poly(A) binding|mRNA splicing, via spliceosome - - - - 8:30384479-30572261 89 69 132 379 354 412 0.408115213059557 0.28755699909981 0.545734644010435 1.55714648388045 1.33187410854881 1.77059395931476 0.413802285389934 1.55320485058134 -1.90823459963327 1.78956724759578e-11 5.23268762093285e-10 DOWN ENSG00000106066 CPVL carboxypeptidase, vitellogenic-like [Source:HGNC Symbol;Acc:HGNC:14399] GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0031982|GO:0008233|GO:0070062|GO:0019538|GO:0017171|GO:0030163|GO:0044265|GO:0006508|GO:0008236|GO:0044267|GO:0044257|GO:0051603|GO:0008238|GO:0070008|GO:0004180|GO:0004185 cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|vesicle|peptidase activity|extracellular exosome|protein metabolic process|serine hydrolase activity|protein catabolic process|cellular macromolecule catabolic process|proteolysis|serine-type peptidase activity|cellular protein metabolic process|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|exopeptidase activity|serine-type exopeptidase activity|carboxypeptidase activity|serine-type carboxypeptidase activity - - - - 7:28995231-29195451 442 476 581 1302 1393 1493 5.34091092653992 5.22733458130386 6.32970282865756 14.096192861459 13.8105816696778 16.9075894767687 5.63264944550045 14.9381213359685 -1.40711313009716 1.80595954375430e-11 5.27545168485724e-10 DOWN ENSG00000148156 ACTL7B actin like 7B [Source:HGNC Symbol;Acc:HGNC:162] GO:0005198|GO:0005623|GO:0005200|GO:0043229|GO:0005622|GO:0005737|GO:0005856|GO:0015629 structural molecule activity|cell|structural constituent of cytoskeleton|intracellular organelle|intracellular|cytoplasm|cytoskeleton|actin cytoskeleton - - - - 9:108854589-108856967 43 17 20 1 0 0 1.27856614507917 0.45940082387644 0.536175300518819 0.0266283284997108 0 0 0.758047423158143 0.0088761094999036 6.41621683003064 1.8134571364958e-11 5.29186329997708e-10 UP ENSG00000172985 SH3RF3 SH3 domain containing ring finger 3 [Source:HGNC Symbol;Acc:HGNC:24699] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|protein binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 2:109129348-109504632 4 4 12 46 61 83 0.0487565486459866 0.0443131498046317 0.131886373248417 0.502393759002293 0.610088872578534 0.948203004283064 0.0749853572330118 0.68689521195463 -3.19540922219632 1.81512293802389e-11 5.29186329997708e-10 DOWN ENSG00000272333 KMT2B lysine (K)-specific methyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:15840] GO:0032502|GO:0032991|GO:0000003|GO:0007610|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0009892|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0042698|GO:0019953|GO:0044237|GO:0003006|GO:0016043|GO:0043227|GO:0044708|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0022602|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0006725|GO:0048468|GO:0009994|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0048608|GO:0001541|GO:0043169|GO:0030728|GO:0007548|GO:0016458|GO:0006139|GO:0008406|GO:0007276|GO:0007611|GO:0048869|GO:0044249|GO:0019538|GO:0007281|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0003677|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0008585|GO:0061458|GO:0010629|GO:0031056|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0048477|GO:0046545|GO:0010628|GO:0036211|GO:0007613|GO:0031981|GO:1990234|GO:0005654|GO:0033043|GO:0044267|GO:0010467|GO:0050890|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0035097|GO:0016070|GO:0007292|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0033044|GO:0040029|GO:0031060|GO:0045815|GO:0018022|GO:0008276|GO:0034968|GO:0046914|GO:0016568|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0016279|GO:0051568|GO:1903506|GO:0018193|GO:0042054|GO:0048096|GO:0051569|GO:0006338|GO:0008270|GO:0018023|GO:0018024|GO:0018205|GO:0080182|GO:0042800 developmental process|macromolecular complex|reproduction|behavior|cell|rhythmic process|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|catalytic activity|methylation|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|ovulation cycle|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|single-organism behavior|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|ovulation cycle process|protein binding|protein complex|transferase activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|cellular aromatic compound metabolic process|cell development|oocyte differentiation|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|reproductive structure development|ovarian follicle development|cation binding|ovulation|sex differentiation|gene silencing|nucleobase-containing compound metabolic process|gonad development|gamete generation|learning or memory|cellular developmental process|cellular biosynthetic process|protein metabolic process|germ cell development|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|DNA binding|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|female gonad development|reproductive system development|negative regulation of gene expression|regulation of histone modification|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|oogenesis|development of primary female sexual characteristics|positive regulation of gene expression|protein modification process|memory|nuclear lumen|transferase complex|nucleoplasm|regulation of organelle organization|cellular protein metabolic process|gene expression|cognition|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|histone methyltransferase complex|RNA metabolic process|female gamete generation|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of chromosome organization|regulation of gene expression, epigenetic|regulation of histone methylation|positive regulation of gene expression, epigenetic|peptidyl-lysine methylation|protein methyltransferase activity|histone lysine methylation|transition metal ion binding|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|protein-lysine N-methyltransferase activity|histone H3-K4 methylation|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone methyltransferase activity|chromatin-mediated maintenance of transcription|regulation of histone H3-K4 methylation|chromatin remodeling|zinc ion binding|peptidyl-lysine trimethylation|histone-lysine N-methyltransferase activity|peptidyl-lysine modification|histone H3-K4 trimethylation|histone methyltransferase activity (H3-K4 specific) K14959 histone-lysine N-methyltransferase MLL4[2.1.1.43] hsa00310 Lysine degradation - Homo sapiens (human) 19:35718019-35738878 2480 2512 2530 1045 1274 1016 15.3587275615622 14.1384946043223 14.1266211176151 5.79852730658612 6.47352856959382 5.89693392696636 14.5412810944999 6.0563299343821 1.26363866989194 1.83418271571622e-11 5.34221373609678e-10 UP ENSG00000244165 P2RY11 purinergic receptor P2Y, G-protein coupled, 11 [Source:HGNC Symbol;Acc:HGNC:8540] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0038023|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005886|GO:0019222|GO:0030594|GO:0006725|GO:1901360|GO:0034641|GO:0044281|GO:0006952|GO:0019637|GO:0031325|GO:0046483|GO:0005887|GO:0010243|GO:0004888|GO:0007267|GO:0006139|GO:0031226|GO:0043085|GO:0055086|GO:0007154|GO:0007165|GO:0050790|GO:0016021|GO:0044249|GO:0010033|GO:0031323|GO:0023041|GO:0007186|GO:0007166|GO:0014074|GO:0051349|GO:0019693|GO:0046683|GO:0071417|GO:0031279|GO:0033198|GO:0014070|GO:0006796|GO:0035556|GO:1901137|GO:0051174|GO:0071310|GO:0031281|GO:0031328|GO:0004930|GO:0007200|GO:0001609|GO:0009259|GO:0009117|GO:0046390|GO:0001614|GO:0071318|GO:0071407|GO:0045761|GO:0006163|GO:0045762|GO:0019932|GO:0009165|GO:0035590|GO:0006164|GO:0030801|GO:0035589|GO:0007190|GO:0009187|GO:0045031|GO:0019722|GO:0045028|GO:0001973|GO:0030802|GO:0007268|GO:0009190|GO:0046058|GO:0030819|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030816|GO:0006171 signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|signaling receptor activity|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|plasma membrane|regulation of metabolic process|neurotransmitter receptor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|integral component of plasma membrane|response to organonitrogen compound|transmembrane signaling receptor activity|cell-cell signaling|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|neuronal signal transduction|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|response to purine-containing compound|positive regulation of lyase activity|ribose phosphate metabolic process|response to organophosphorus|cellular response to organonitrogen compound|regulation of cyclase activity|response to ATP|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|cellular response to organic substance|positive regulation of cyclase activity|positive regulation of cellular biosynthetic process|G-protein coupled receptor activity|phospholipase C-activating G-protein coupled receptor signaling pathway|G-protein coupled adenosine receptor activity|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|purinergic nucleotide receptor activity|cellular response to ATP|cellular response to organic cyclic compound|regulation of adenylate cyclase activity|purine nucleotide metabolic process|positive regulation of adenylate cyclase activity|second-messenger-mediated signaling|nucleotide biosynthetic process|purinergic nucleotide receptor signaling pathway|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|G-protein coupled purinergic nucleotide receptor signaling pathway|activation of adenylate cyclase activity|cyclic nucleotide metabolic process|ATP-activated adenosine receptor activity|calcium-mediated signaling|G-protein coupled purinergic nucleotide receptor activity|adenosine receptor signaling pathway|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|cyclic nucleotide biosynthetic process|cAMP metabolic process|positive regulation of cAMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|positive regulation of cAMP metabolic process|cAMP biosynthetic process K08387 purinergic receptor P2Y, G protein-coupled, 11[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 19:10111538-10115372 619 967 103 28 20 44 17.5354811469185 24.8962404423043 2.63074588897763 0.71069273319156 0.464854409109591 1.16817195849884 15.0208224927335 0.781239700266664 4.26505473766973 1.91612334830399e-11 5.57543337624436e-10 UP ENSG00000164649 CDCA7L cell division cycle associated 7-like [Source:HGNC Symbol;Acc:HGNC:30777] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0016021|GO:0044249|GO:0031323|GO:0005730|GO:0010468|GO:0034645|GO:0051252|GO:0031981|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|membrane|cellular process|metabolic process|binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|integral component of membrane|cellular biosynthetic process|regulation of cellular metabolic process|nucleolus|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|nuclear lumen|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 7:21900900-21946084 357 387 681 1530 1497 1476 3.23383807646314 3.1859670033625 5.56175593058333 12.4176507183561 11.1260293793973 12.530417478817 3.99385367013632 12.0246991921901 -1.59014742393622 1.96547059786202e-11 5.71345269995841e-10 DOWN ENSG00000115289 PCGF1 polycomb group ring finger 1 [Source:HGNC Symbol;Acc:HGNC:17615] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:0008022|GO:1901360|GO:0016570|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0031519|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0051252|GO:0006325|GO:0036211|GO:0016574|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0010390|GO:0033522|GO:0046914|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:1903506|GO:0035518|GO:0008270|GO:0032446|GO:0016567|GO:0006513 macromolecular complex|cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|protein C-terminus binding|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|PcG protein complex|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|regulation of RNA metabolic process|chromatin organization|protein modification process|histone ubiquitination|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|histone monoubiquitination|histone H2A ubiquitination|transition metal ion binding|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|histone H2A monoubiquitination|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination|protein monoubiquitination K11487 polycomb group RING finger protein 1[-] hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) 2:74505043-74508580 628 588 577 245 249 206 10.3573633995951 8.81347504588682 8.57984801841326 3.62036928978133 3.36943918959382 3.18408858704117 9.25022882129839 3.39129902213877 1.44765105656377 1.97071980229042e-11 5.723139005601e-10 UP ENSG00000145348 TBCK TBC1 domain containing kinase [Source:HGNC Symbol;Acc:HGNC:28261] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0043167|GO:0044237|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468 cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|ion binding|cellular metabolic process|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation - - - - 4:106041599-106321495 78 65 112 296 326 393 0.323738951695856 0.245186003625969 0.419112924870662 1.10075052452635 1.1101576648653 1.52869457865175 0.329345960064162 1.24653425601447 -1.92024677161736 1.99888657178938e-11 5.79668005347043e-10 DOWN ENSG00000173517 PEAK1 pseudopodium-enriched atypical kinase 1 [Source:HGNC Symbol;Acc:HGNC:29431] GO:0040011|GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0030055|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0048468|GO:0034446|GO:0043168|GO:0005924|GO:0005912|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0006928|GO:0031589|GO:0016477|GO:0000166|GO:0048869|GO:0019538|GO:0000902|GO:0035639|GO:0043412|GO:0001883|GO:0000904|GO:0036211|GO:0032549|GO:0031981|GO:0005654|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0030154|GO:0016773|GO:0005856|GO:0005634|GO:0005925|GO:0015629|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004713|GO:0018193|GO:0004715|GO:0046777|GO:0018108 locomotion|developmental process|cell|membrane|cellular process|metabolic process|cell junction|binding|catalytic activity|small molecule binding|organic cyclic compound binding|cell-substrate junction|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|transferase activity|anatomical structure development|cell development|substrate adhesion-dependent cell spreading|anion binding|cell-substrate adherens junction|adherens junction|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|cell-substrate adhesion|cell migration|nucleotide binding|cellular developmental process|protein metabolic process|cell morphogenesis|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|cell morphogenesis involved in differentiation|protein modification process|ribonucleoside binding|nuclear lumen|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|cell differentiation|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|focal adhesion|actin cytoskeleton|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein tyrosine kinase activity|peptidyl-amino acid modification|non-membrane spanning protein tyrosine kinase activity|protein autophosphorylation|peptidyl-tyrosine phosphorylation - - - - 15:77100656-77420144 38 72 98 280 306 345 0.0674074758363986 0.116074071512225 0.156734849636895 0.445019978082737 0.445361376802484 0.573550501343612 0.11340546566184 0.487977285409611 -2.10532382039099 1.99992646046578e-11 5.79668005347043e-10 DOWN ENSG00000103043 VAC14 Vac14 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:25507] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0004872|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0016032|GO:0044255|GO:0044281|GO:0019637|GO:0043231|GO:0005774|GO:0005737|GO:0005942|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0010008|GO:0050790|GO:0044249|GO:0031323|GO:0005794|GO:0005768|GO:0008654|GO:0046486|GO:0035032|GO:0005769|GO:0005773|GO:0005770|GO:1990234|GO:0070772|GO:0031901|GO:0006796|GO:0051174|GO:0008610|GO:0019216|GO:0000139|GO:0031902|GO:0006644|GO:0046474|GO:0043550|GO:0016310|GO:0043549|GO:0006650|GO:0046488|GO:0006661|GO:0042325 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|receptor activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|viral process|cellular lipid metabolic process|small molecule metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|phosphatidylinositol 3-kinase complex|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|endosome membrane|regulation of catalytic activity|cellular biosynthetic process|regulation of cellular metabolic process|Golgi apparatus|endosome|phospholipid biosynthetic process|glycerolipid metabolic process|phosphatidylinositol 3-kinase complex, class III|early endosome|vacuole|late endosome|transferase complex|PAS complex|early endosome membrane|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|lipid biosynthetic process|regulation of lipid metabolic process|Golgi membrane|late endosome membrane|phospholipid metabolic process|glycerophospholipid biosynthetic process|regulation of lipid kinase activity|phosphorylation|regulation of kinase activity|glycerophospholipid metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|regulation of phosphorylation K15305 vacuole morphology and inheritance protein 14[-] hsa05166|hsa05203 HTLV-I infection - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human) 16:70687439-70801161 275 336 413 891 1182 898 1.58965631556391 1.76518211151159 2.15245849611248 4.61472976917826 5.60603849936656 4.8649239294544 1.83576564106266 5.02856406599974 -1.45376459731842 2.02091684195446e-11 5.85183815710073e-10 DOWN ENSG00000148484 RSU1 Ras suppressor protein 1 [Source:HGNC Symbol;Acc:HGNC:10464] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0030055|GO:0050794|GO:0016043|GO:0007155|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0019222|GO:0005924|GO:0030155|GO:0005912|GO:0031982|GO:0022607|GO:0005737|GO:0031589|GO:0043085|GO:0007154|GO:0007165|GO:0070062|GO:0045785|GO:0050790|GO:0005829|GO:0051345|GO:0034329|GO:0010810|GO:0010811|GO:0005925|GO:0043087|GO:0043547 signaling|cell|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell-substrate junction|regulation of cellular process|cellular component organization|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|regulation of metabolic process|cell-substrate adherens junction|regulation of cell adhesion|adherens junction|vesicle|cellular component assembly|cytoplasm|cell-substrate adhesion|positive regulation of catalytic activity|cell communication|signal transduction|extracellular exosome|positive regulation of cell adhesion|regulation of catalytic activity|cytosol|positive regulation of hydrolase activity|cell junction assembly|regulation of cell-substrate adhesion|positive regulation of cell-substrate adhesion|focal adhesion|regulation of GTPase activity|positive regulation of GTPase activity - - - - 10:16590611-16817528 145 152 226 592 555 547 1.25619884685862 1.19677524997165 1.76527118936128 4.59524585168466 3.94503371793271 4.44125980531389 1.40608176206385 4.32717979164375 -1.62174657715748 2.06457648020779e-11 5.97246765892668e-10 DOWN ENSG00000204104 TRAF3IP1 TRAF3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:17861] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0002683|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0051707|GO:0009607|GO:0009605|GO:0023057|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0019222|GO:0007507|GO:0001818|GO:0030992|GO:0009888|GO:0006810|GO:0035295|GO:0005930|GO:0036342|GO:0007275|GO:0050688|GO:0048513|GO:0030990|GO:0006952|GO:0051128|GO:0022607|GO:0098542|GO:0001817|GO:0007389|GO:0001816|GO:0045992|GO:0032886|GO:0007423|GO:0006928|GO:0032403|GO:0009615|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0045184|GO:0072372|GO:0036064|GO:0010646|GO:0008104|GO:0007154|GO:0010970|GO:0007165|GO:0009968|GO:0051649|GO:0008092|GO:0097542|GO:0050687|GO:0051607|GO:0030030|GO:0048869|GO:0007017|GO:0019538|GO:0043254|GO:0031324|GO:0031323|GO:0006996|GO:0015631|GO:0032268|GO:0000902|GO:0005813|GO:0031333|GO:0032479|GO:0042733|GO:0007166|GO:0001654|GO:0002009|GO:0043412|GO:0007010|GO:0072358|GO:0070507|GO:0035050|GO:0005815|GO:1901621|GO:0015031|GO:0008589|GO:0009790|GO:0008017|GO:0045879|GO:0036211|GO:0044782|GO:0032269|GO:0046907|GO:0003002|GO:0021532|GO:0030031|GO:0032480|GO:0007018|GO:0032606|GO:0006461|GO:0034613|GO:0070925|GO:0060429|GO:0006796|GO:0042384|GO:0033043|GO:0035108|GO:0044267|GO:0051174|GO:0032990|GO:0031503|GO:0007399|GO:0051246|GO:0048858|GO:0060173|GO:0072359|GO:0000226|GO:0005856|GO:0051960|GO:0045995|GO:0031076|GO:0032688|GO:0060271|GO:0009792|GO:0042073|GO:0021904|GO:0043010|GO:0007224|GO:0016310|GO:0006886|GO:0051493|GO:0015630|GO:0009953|GO:0032608|GO:0006464|GO:0030705|GO:0032648|GO:0030326|GO:1901620|GO:0001738|GO:0006468|GO:0060831|GO:0042325|GO:0001932|GO:0042326|GO:0043009|GO:0001933 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to other organism|response to biotic stimulus|response to external stimulus|negative regulation of signaling|regulation of developmental process|intracellular|regulation of immune system process|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|negative regulation of cytokine production|intraciliary transport particle B|tissue development|transport|tube development|axoneme|post-anal tail morphogenesis|multicellular organism development|regulation of defense response to virus|animal organ development|intraciliary transport particle|defense response|regulation of cellular component organization|cellular component assembly|defense response to other organism|regulation of cytokine production|pattern specification process|cytokine production|negative regulation of embryonic development|regulation of microtubule-based process|sensory organ development|movement of cell or subcellular component|protein complex binding|response to virus|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|establishment of protein localization|primary cilium|ciliary basal body|regulation of cell communication|protein localization|cell communication|establishment of localization by movement along microtubule|signal transduction|negative regulation of signal transduction|establishment of localization in cell|cytoskeletal protein binding|ciliary tip|negative regulation of defense response to virus|defense response to virus|cell projection organization|cellular developmental process|microtubule-based process|protein metabolic process|regulation of protein complex assembly|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|tubulin binding|regulation of cellular protein metabolic process|cell morphogenesis|centrosome|negative regulation of protein complex assembly|regulation of type I interferon production|embryonic digit morphogenesis|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|macromolecule modification|cytoskeleton organization|cardiovascular system development|regulation of microtubule cytoskeleton organization|embryonic heart tube development|microtubule organizing center|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|protein transport|regulation of smoothened signaling pathway|embryo development|microtubule binding|negative regulation of smoothened signaling pathway|protein modification process|cilium organization|negative regulation of cellular protein metabolic process|intracellular transport|regionalization|neural tube patterning|cell projection assembly|negative regulation of type I interferon production|microtubule-based movement|type I interferon production|protein complex assembly|cellular protein localization|organelle assembly|epithelium development|phosphate-containing compound metabolic process|cilium assembly|regulation of organelle organization|limb morphogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|protein complex localization|nervous system development|regulation of protein metabolic process|cell projection morphogenesis|limb development|circulatory system development|microtubule cytoskeleton organization|cytoskeleton|regulation of nervous system development|regulation of embryonic development|embryonic camera-type eye development|negative regulation of interferon-beta production|cilium morphogenesis|embryo development ending in birth or egg hatching|intraciliary transport|dorsal/ventral neural tube patterning|camera-type eye development|smoothened signaling pathway|phosphorylation|intracellular protein transport|regulation of cytoskeleton organization|microtubule cytoskeleton|dorsal/ventral pattern formation|interferon-beta production|cellular protein modification process|cytoskeleton-dependent intracellular transport|regulation of interferon-beta production|embryonic limb morphogenesis|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|morphogenesis of a polarized epithelium|protein phosphorylation|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|chordate embryonic development|negative regulation of protein phosphorylation - - - - 2:238320441-238400900 168 207 214 636 682 522 1.56016393105985 1.74707915912108 1.79180377911619 5.29196216036418 5.19653847130655 4.54319694442612 1.69968228976571 5.01056585869895 -1.559708442398 2.08656856091234e-11 6.03024373838112e-10 DOWN ENSG00000166833 NAV2 neuron navigator 2 [Source:HGNC Symbol;Acc:HGNC:15997] GO:0032502|GO:0031012|GO:0007610|GO:0005623|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0005578|GO:0043167|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0007626|GO:0048856|GO:0008201|GO:0007275|GO:0050877|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005614|GO:0021675|GO:0008217|GO:0000166|GO:0005539|GO:0003013|GO:0035639|GO:0007417|GO:0048483|GO:0001883|GO:0016818|GO:0048486|GO:0001976|GO:0032549|GO:0007600|GO:0031981|GO:0005654|GO:0007399|GO:0017076|GO:0008015|GO:0005634|GO:0003073|GO:0021545|GO:0021564|GO:0050954|GO:0005524|GO:0021554|GO:0030554|GO:0021563|GO:0007606|GO:0016462|GO:0003025|GO:0007608|GO:0007605|GO:0017111|GO:0004386 developmental process|extracellular matrix|behavior|cell|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|proteinaceous extracellular matrix|ion binding|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|locomotory behavior|anatomical structure development|heparin binding|multicellular organism development|neurological system process|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|interstitial matrix|nerve development|regulation of blood pressure|nucleotide binding|glycosaminoglycan binding|circulatory system process|purine ribonucleoside triphosphate binding|central nervous system development|autonomic nervous system development|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|parasympathetic nervous system development|neurological system process involved in regulation of systemic arterial blood pressure|ribonucleoside binding|sensory perception|nuclear lumen|nucleoplasm|nervous system development|purine nucleotide binding|blood circulation|nucleus|regulation of systemic arterial blood pressure|cranial nerve development|vagus nerve development|sensory perception of mechanical stimulus|ATP binding|optic nerve development|adenyl nucleotide binding|glossopharyngeal nerve development|sensory perception of chemical stimulus|pyrophosphatase activity|regulation of systemic arterial blood pressure by baroreceptor feedback|sensory perception of smell|sensory perception of sound|nucleoside-triphosphatase activity|helicase activity - - - - 11:19350724-20121598 11 10 66 309 326 653 0.0414855151900333 0.0342755929191029 0.224419808865196 1.04414641790816 1.00876610590207 2.30806256778795 0.100060305658111 1.45365836386606 -3.86074657992073 2.13374692576134e-11 6.16062676225137e-10 DOWN ENSG00000238271 IFNWP19 interferon, omega 1 pseudogene 19 [Source:HGNC Symbol;Acc:HGNC:5451] - - - - - - 9:21455484-21456049 29 31 25 187 155 111 3.62433342212038 3.52108973340817 2.81699280166249 20.9395806874555 15.8938271116539 13.0011209446677 3.32080531906368 16.611509581259 -2.32257813207676 2.20168536430581e-11 6.35063911748654e-10 DOWN ENSG00000103227 LMF1 lipase maturation factor 1 [Source:HGNC Symbol;Acc:HGNC:14154] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0097006|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0006486|GO:0044255|GO:0006810|GO:1901360|GO:0044281|GO:0032940|GO:0043231|GO:0005737|GO:0005975|GO:0045184|GO:0043085|GO:0008104|GO:0006629|GO:0005783|GO:0051649|GO:0007586|GO:0050790|GO:0016021|GO:0034381|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0090207|GO:0016192|GO:0034645|GO:0046486|GO:0043412|GO:0051345|GO:0006066|GO:0051604|GO:0015031|GO:0033578|GO:0009100|GO:0036211|GO:0046907|GO:0044241|GO:0006638|GO:0009306|GO:0070085|GO:0008202|GO:1901137|GO:0044267|GO:0010467|GO:0019216|GO:0046903|GO:0009059|GO:0009101|GO:0043413|GO:0034382|GO:0019218|GO:0048193|GO:0016125|GO:0006639|GO:0006464|GO:0060193|GO:0061365|GO:0090181|GO:0008203|GO:0006888|GO:0006641|GO:0051006 cell|membrane|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of plasma lipoprotein particle levels|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|protein glycosylation|cellular lipid metabolic process|transport|organic cyclic compound metabolic process|small molecule metabolic process|secretion by cell|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|establishment of protein localization|positive regulation of catalytic activity|protein localization|lipid metabolic process|endoplasmic reticulum|establishment of localization in cell|digestion|regulation of catalytic activity|integral component of membrane|plasma lipoprotein particle clearance|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of triglyceride metabolic process|vesicle-mediated transport|cellular macromolecule biosynthetic process|glycerolipid metabolic process|macromolecule modification|positive regulation of hydrolase activity|alcohol metabolic process|protein maturation|protein transport|protein glycosylation in Golgi|glycoprotein metabolic process|protein modification process|intracellular transport|lipid digestion|neutral lipid metabolic process|protein secretion|glycosylation|steroid metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|gene expression|regulation of lipid metabolic process|secretion|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|chylomicron remnant clearance|regulation of steroid metabolic process|Golgi vesicle transport|sterol metabolic process|acylglycerol metabolic process|cellular protein modification process|positive regulation of lipase activity|positive regulation of triglyceride lipase activity|regulation of cholesterol metabolic process|cholesterol metabolic process|ER to Golgi vesicle-mediated transport|triglyceride metabolic process|positive regulation of lipoprotein lipase activity - - - - 16:853634-981318 15 33 35 121 144 181 0.0775498154288061 0.155058572815901 0.163148548875026 0.560502458227803 0.610839149869382 0.8770063415528 0.131918979039911 0.682782649883328 -2.37177426017592 2.22596023879778e-11 6.41446109740048e-10 DOWN ENSG00000175820 CCDC168 coiled-coil domain containing 168 [Source:HGNC Symbol;Acc:HGNC:26851] - - - - - - 13:102729369-102759070 64 61 32 6 2 7 0.210898481856389 0.182686846710198 0.0950727157151353 0.0177156953154294 0.00540707788222173 0.0216188733063649 0.162886014760574 0.0149138821680053 3.44913498743544 2.30713450224113e-11 6.64196657954743e-10 UP ENSG00000188559 RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) [Source:HGNC Symbol;Acc:HGNC:16207] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0016043|GO:0071944|GO:0009893|GO:0005615|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0008047|GO:0005737|GO:0009966|GO:0046983|GO:0010646|GO:0043085|GO:0007154|GO:0061024|GO:0007165|GO:0050790|GO:0005096|GO:0051345|GO:0046982|GO:0030695|GO:0035556|GO:1902531|GO:0043087|GO:0043547|GO:0051056|GO:0007264|GO:0090630 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|cellular component organization|cell periphery|positive regulation of metabolic process|extracellular space|enzyme regulator activity|intracellular|protein binding|plasma membrane|regulation of metabolic process|enzyme activator activity|cytoplasm|regulation of signal transduction|protein dimerization activity|regulation of cell communication|positive regulation of catalytic activity|cell communication|membrane organization|signal transduction|regulation of catalytic activity|GTPase activator activity|positive regulation of hydrolase activity|protein heterodimerization activity|GTPase regulator activity|intracellular signal transduction|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|activation of GTPase activity - - - - 20:20389552-20712488 45 37 138 423 447 742 0.242472271864692 0.181189869102943 0.670412167160668 2.04213672597627 1.97616128198213 3.74697048631187 0.364691436042768 2.58842283142342 -2.82732508107378 2.31970163907448e-11 6.6717122093381e-10 DOWN ENSG00000118777 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) [Source:HGNC Symbol;Acc:HGNC:74] GO:0032502|GO:0000003|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0022857|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0045177|GO:0043227|GO:0071944|GO:0009605|GO:0032504|GO:0016787|GO:0031224|GO:0042910|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0031090|GO:0048609|GO:0042802|GO:0060136|GO:0015238|GO:0006725|GO:0008559|GO:0006810|GO:1901360|GO:0006082|GO:0016324|GO:0009991|GO:0007275|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0016817|GO:0043231|GO:0010243|GO:0005737|GO:0042592|GO:0015232|GO:0046983|GO:0031966|GO:0019725|GO:0042493|GO:0055085|GO:0007565|GO:0009725|GO:0000166|GO:0016021|GO:0010035|GO:0010033|GO:0007584|GO:0005740|GO:0016820|GO:0006855|GO:0033993|GO:0035639|GO:0048878|GO:0001883|GO:0009790|GO:0046415|GO:0010038|GO:0043200|GO:0016818|GO:0051181|GO:0032549|GO:0055082|GO:0033273|GO:0042908|GO:0015893|GO:0005739|GO:0014070|GO:0071310|GO:0017076|GO:0010039|GO:0031667|GO:0032870|GO:0005634|GO:0042803|GO:0048545|GO:0097305|GO:0009792|GO:0015886|GO:0005524|GO:0030554|GO:0071383|GO:0071407|GO:0050801|GO:0042626|GO:0071396|GO:0031960|GO:0016462|GO:0071548|GO:0046618|GO:0006873|GO:0051593|GO:0051384|GO:0071549|GO:0017111|GO:0071384|GO:0030003|GO:0016887|GO:0071385|GO:0055065|GO:0006875|GO:0042623|GO:0006879|GO:0055072|GO:0043492 developmental process|reproduction|transporter activity|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|apical part of cell|membrane-bounded organelle|cell periphery|response to external stimulus|multicellular organism reproduction|hydrolase activity|intrinsic component of membrane|xenobiotic transporter activity|intracellular|protein binding|plasma membrane|anatomical structure development|organelle membrane|multicellular organismal reproductive process|identical protein binding|embryonic process involved in female pregnancy|drug transmembrane transporter activity|cellular aromatic compound metabolic process|xenobiotic-transporting ATPase activity|transport|organic cyclic compound metabolic process|organic acid metabolic process|apical plasma membrane|response to extracellular stimulus|multicellular organism development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|homeostatic process|heme transporter activity|protein dimerization activity|mitochondrial membrane|cellular homeostasis|response to drug|transmembrane transport|female pregnancy|response to hormone|nucleotide binding|integral component of membrane|response to inorganic substance|response to organic substance|response to nutrient|mitochondrial envelope|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|drug transmembrane transport|response to lipid|purine ribonucleoside triphosphate binding|chemical homeostasis|purine nucleoside binding|embryo development|urate metabolic process|response to metal ion|response to amino acid|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cofactor transport|ribonucleoside binding|cellular chemical homeostasis|response to vitamin|xenobiotic transport|drug transport|mitochondrion|response to organic cyclic compound|cellular response to organic substance|purine nucleotide binding|response to iron ion|response to nutrient levels|cellular response to hormone stimulus|nucleus|protein homodimerization activity|response to steroid hormone|response to alcohol|embryo development ending in birth or egg hatching|heme transport|ATP binding|adenyl nucleotide binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|ion homeostasis|ATPase activity, coupled to transmembrane movement of substances|cellular response to lipid|response to corticosteroid|pyrophosphatase activity|response to dexamethasone|drug export|cellular ion homeostasis|response to folic acid|response to glucocorticoid|cellular response to dexamethasone stimulus|nucleoside-triphosphatase activity|cellular response to corticosteroid stimulus|cellular cation homeostasis|ATPase activity|cellular response to glucocorticoid stimulus|metal ion homeostasis|cellular metal ion homeostasis|ATPase activity, coupled|cellular iron ion homeostasis|iron ion homeostasis|ATPase activity, coupled to movement of substances K05681 ATP-binding cassette, subfamily G (WHITE), member 2[-] hsa04976|hsa02010 Bile secretion - Homo sapiens (human)|ABC transporters - Homo sapiens (human) 4:88090264-88231322 443 538 701 1809 1891 1338 4.34624036011629 4.79703597335022 6.20072764958471 15.9018145927788 15.2219409795603 12.30256157586 5.11466799435041 14.4754390493997 -1.50089460750143 2.36857794320192e-11 6.8057291546054e-10 DOWN ENSG00000163938 GNL3 guanine nucleotide binding protein-like 3 (nucleolar) [Source:HGNC Symbol;Acc:HGNC:29931] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0019222|GO:0042127|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0031325|GO:0046483|GO:0016817|GO:0043231|GO:0006139|GO:0000166|GO:0044249|GO:0022613|GO:0031323|GO:0005730|GO:0010468|GO:0034645|GO:0003723|GO:0035639|GO:0051252|GO:0001883|GO:0042254|GO:0010628|GO:0016818|GO:0032549|GO:0031981|GO:0005654|GO:0010467|GO:0017076|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0032561|GO:0045893|GO:0032774|GO:2001141|GO:0044822|GO:0005525|GO:0019001|GO:0016462|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0017111|GO:1902895|GO:0003924 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|extracellular space|intracellular|protein binding|regulation of metabolic process|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|nucleolus|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|purine ribonucleoside triphosphate binding|regulation of RNA metabolic process|purine nucleoside binding|ribosome biogenesis|positive regulation of gene expression|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|nucleoplasm|gene expression|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|guanyl ribonucleotide binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|poly(A) RNA binding|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|GTPase activity K14538 nuclear GTP-binding protein[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 3:52681156-52694492 5954 5877 4959 2390 2535 1906 74.595686686902 66.9176393088691 56.0161382270662 26.8287474802287 26.0585822337849 22.3798258871362 65.8431547409458 25.0890518670499 1.39197550990144 2.42325050602735e-11 6.95612698143658e-10 UP ENSG00000108100 CCNY cyclin Y [Source:HGNC Symbol;Acc:HGNC:23354] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0051726|GO:0007049|GO:0022402|GO:0031982|GO:0031325|GO:0043231|GO:0019899|GO:0005737|GO:0009966|GO:0045787|GO:0010646|GO:0043085|GO:0000307|GO:0007154|GO:0007165|GO:0070062|GO:0050790|GO:0051301|GO:0019207|GO:0019538|GO:0031323|GO:0032268|GO:0030111|GO:0000308|GO:0007166|GO:1903047|GO:0043412|GO:0019887|GO:0044770|GO:0051347|GO:0036211|GO:0000278|GO:0045737|GO:1990234|GO:0051247|GO:0019900|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0005634|GO:0016055|GO:1904031|GO:0031401|GO:0060828|GO:0000086|GO:0044772|GO:0016310|GO:0016538|GO:0019901|GO:0006464|GO:0000079|GO:0043549|GO:0033674|GO:0045859|GO:0045860|GO:1902911|GO:0006468|GO:0060070|GO:0042325|GO:0001932|GO:0001934|GO:0042327|GO:1902554|GO:0071902|GO:0071900 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|protein complex|regulation of metabolic process|regulation of cell cycle|cell cycle|cell cycle process|vesicle|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of signal transduction|positive regulation of cell cycle|regulation of cell communication|positive regulation of catalytic activity|cyclin-dependent protein kinase holoenzyme complex|cell communication|signal transduction|extracellular exosome|regulation of catalytic activity|cell division|kinase regulator activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cytoplasmic cyclin-dependent protein kinase holoenzyme complex|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|protein kinase regulator activity|cell cycle phase transition|positive regulation of transferase activity|protein modification process|mitotic cell cycle|positive regulation of cyclin-dependent protein serine/threonine kinase activity|transferase complex|positive regulation of protein metabolic process|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|nucleus|Wnt signaling pathway|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein modification process|regulation of canonical Wnt signaling pathway|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|phosphorylation|cyclin-dependent protein serine/threonine kinase regulator activity|protein kinase binding|cellular protein modification process|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein kinase complex|protein phosphorylation|canonical Wnt signaling pathway|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|serine/threonine protein kinase complex|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity - - - - 10:35247025-35572669 278 275 384 952 1006 783 2.04331443816235 1.83697407485474 2.54469082327521 6.26938070437668 6.06674795141537 5.3936228358053 2.1416597787641 5.90991716386578 -1.46440859539629 2.51791242337314e-11 7.22091810637672e-10 DOWN ENSG00000265763 ZNF488 zinc finger protein 488 [Source:HGNC Symbol;Acc:HGNC:23535] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0045597|GO:0043231|GO:0043169|GO:0009890|GO:0006139|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0007417|GO:0021782|GO:0010629|GO:0010720|GO:0051252|GO:0050769|GO:0010467|GO:0007399|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0051960|GO:0010001|GO:0045892|GO:0032774|GO:2001141|GO:0014003|GO:1902679|GO:0014015|GO:0048709|GO:0022008|GO:0050767|GO:0006351|GO:0006355|GO:1903507|GO:0048699|GO:0014013|GO:1903506|GO:0045685|GO:0045687|GO:0042063|GO:0048714|GO:0048713 developmental process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|central nervous system development|glial cell development|negative regulation of gene expression|positive regulation of cell development|regulation of RNA metabolic process|positive regulation of neurogenesis|gene expression|nervous system development|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|regulation of nervous system development|glial cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|oligodendrocyte development|negative regulation of RNA biosynthetic process|positive regulation of gliogenesis|oligodendrocyte differentiation|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|generation of neurons|regulation of gliogenesis|regulation of nucleic acid-templated transcription|regulation of glial cell differentiation|positive regulation of glial cell differentiation|gliogenesis|positive regulation of oligodendrocyte differentiation|regulation of oligodendrocyte differentiation - - - - 10:47365496-47384273 262 359 404 916 989 988 2.69846460174067 3.3603919439493 3.75155292998469 8.45295185254618 8.35756732473486 9.53677444568761 3.27013649189155 8.78243120765622 -1.42526951745352 2.5881778672577e-11 7.41530345960761e-10 DOWN ENSG00000120756 PLS1 plastin 1 [Source:HGNC Symbol;Acc:HGNC:9090] GO:0032502|GO:0040007|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0005200|GO:0044877|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0045927|GO:0043227|GO:0071944|GO:0040008|GO:0050793|GO:0048589|GO:0005622|GO:1903829|GO:0005515|GO:0060341|GO:0005903|GO:0040018|GO:0006810|GO:0051130|GO:0005938|GO:0032535|GO:0031982|GO:0051128|GO:0022607|GO:0043169|GO:0005737|GO:0032880|GO:0032403|GO:0035264|GO:0045184|GO:0048639|GO:0008104|GO:0061024|GO:0090004|GO:0070062|GO:0048638|GO:0007586|GO:0008092|GO:0040014|GO:0050892|GO:0030030|GO:0030029|GO:0010256|GO:0006996|GO:0031344|GO:0090150|GO:0030864|GO:0046872|GO:0007010|GO:0032528|GO:0003779|GO:0007009|GO:0070201|GO:0072657|GO:0030036|GO:0034613|GO:0051015|GO:0070925|GO:1903078|GO:0001951|GO:1903827|GO:0008643|GO:0005856|GO:0015629|GO:0090003|GO:0072659|GO:0030866|GO:0090002|GO:0032532|GO:1990357|GO:0005509|GO:1902896|GO:0030865|GO:1903076|GO:0030863|GO:1990778|GO:0008645|GO:0015758 developmental process|growth|structural molecule activity|cell|cellular process|extracellular region|binding|extracellular vesicle|structural constituent of cytoskeleton|macromolecular complex binding|regulation of cellular process|intracellular organelle|ion binding|cellular localization|cellular component organization|positive regulation of growth|membrane-bounded organelle|cell periphery|regulation of growth|regulation of developmental process|developmental growth|intracellular|positive regulation of cellular protein localization|protein binding|regulation of cellular localization|brush border|positive regulation of multicellular organism growth|transport|positive regulation of cellular component organization|cell cortex|regulation of cellular component size|vesicle|regulation of cellular component organization|cellular component assembly|cation binding|cytoplasm|regulation of protein localization|protein complex binding|multicellular organism growth|establishment of protein localization|positive regulation of developmental growth|protein localization|membrane organization|positive regulation of establishment of protein localization to plasma membrane|extracellular exosome|regulation of developmental growth|digestion|cytoskeletal protein binding|regulation of multicellular organism growth|intestinal absorption|cell projection organization|actin filament-based process|endomembrane system organization|organelle organization|regulation of cell projection organization|establishment of protein localization to membrane|cortical actin cytoskeleton|metal ion binding|cytoskeleton organization|microvillus organization|actin binding|plasma membrane organization|regulation of establishment of protein localization|protein localization to membrane|actin cytoskeleton organization|cellular protein localization|actin filament binding|organelle assembly|positive regulation of protein localization to plasma membrane|intestinal D-glucose absorption|regulation of cellular protein localization|carbohydrate transport|cytoskeleton|actin cytoskeleton|regulation of establishment of protein localization to plasma membrane|protein localization to plasma membrane|cortical actin cytoskeleton organization|establishment of protein localization to plasma membrane|regulation of microvillus length|terminal web|calcium ion binding|terminal web assembly|cortical cytoskeleton organization|regulation of protein localization to plasma membrane|cortical cytoskeleton|protein localization to cell periphery|hexose transport|glucose transport - - - - 3:142596387-142713664 599 718 1214 2475 2708 2763 4.72683611155102 5.14930206850598 8.63727718355623 17.4991432897615 17.5331698530647 20.4340141610069 6.17113845453774 18.4887757679444 -1.5830411319239 2.60969054224158e-11 7.46977003337299e-10 DOWN ENSG00000165113 GKAP1 G kinase anchoring protein 1 [Source:HGNC Symbol;Acc:HGNC:17496] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0016772|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0005794|GO:0016301|GO:0006796|GO:0016310 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|endomembrane system|transferase activity|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|Golgi apparatus|kinase activity|phosphate-containing compound metabolic process|phosphorylation - - - - 9:83739421-83829516 4 3 18 66 79 112 0.0598043229322892 0.0407719997664507 0.242655873164414 0.884169950460156 0.969143701817821 1.56941876982872 0.114410731954385 1.1409108073689 -3.31789171966845 2.67030034212087e-11 7.63593356452839e-10 DOWN ENSG00000259768 RP5-991G20.1 - - - - - - - 16:72665170-72791624 40 25 48 181 170 171 0.584360809546551 0.33193163499269 0.632234561645706 2.36916925928517 2.0376922409888 2.34123766926845 0.516175668728316 2.24936638984747 -2.12358463179972 2.69363461797636e-11 7.69528879282932e-10 DOWN ENSG00000064763 FAR2 fatty acyl-CoA reductase 2 [Source:HGNC Symbol;Acc:HGNC:25531] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0044255|GO:0044281|GO:0043231|GO:0005737|GO:0010025|GO:0016903|GO:0051186|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0006790|GO:0055114|GO:0006662|GO:0006637|GO:0016620|GO:0008611|GO:0008610|GO:0046485|GO:0005778|GO:0080019|GO:0005777|GO:0005782|GO:0050062|GO:0035336 cell|membrane|cellular process|metabolic process|catalytic activity|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|wax biosynthetic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors|cofactor metabolic process|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|sulfur compound metabolic process|oxidation-reduction process|glycerol ether metabolic process|acyl-CoA metabolic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|ether lipid biosynthetic process|lipid biosynthetic process|ether lipid metabolic process|peroxisomal membrane|fatty-acyl-CoA reductase (alcohol-forming) activity|peroxisome|peroxisomal matrix|long-chain-fatty-acyl-CoA reductase activity|long-chain fatty-acyl-CoA metabolic process K13356 alcohol-forming fatty acyl-CoA reductase[1.2.1.84] hsa04146 Peroxisome - Homo sapiens (human) 12:29149103-29340980 34 47 68 201 220 192 0.313119862275147 0.393377636033607 0.564610602664893 1.65852553125836 1.66233414144107 1.65713904410638 0.423702700324549 1.65933290560194 -1.96947912934167 2.7008495676963e-11 7.70852418680739e-10 DOWN ENSG00000119771 KLHL29 kelch like family member 29 [Source:HGNC Symbol;Acc:HGNC:29404] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0004842|GO:0031461|GO:0036211|GO:1990234|GO:0044267|GO:0006464|GO:0031463|GO:0032446|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|protein complex|transferase activity|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|protein modification process|transferase complex|cellular protein metabolic process|cellular protein modification process|Cul3-RING ubiquitin ligase complex|protein modification by small protein conjugation|protein ubiquitination - - - - 2:23385217-23708611 38 51 60 173 211 267 0.184704728504643 0.225292574087158 0.262943473610188 0.753420933884158 0.841479555936607 1.21628190420282 0.22431359206733 0.937060798007862 -2.06262561349247 2.78041700170071e-11 7.92803908011203e-10 DOWN ENSG00000102098 SCML2 sex comb on midleg-like 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:10581] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0031519|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 developmental process|macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|PcG protein complex|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:18239314-18354727 197 262 316 73 97 49 2.20982261018126 2.67099161825503 3.19589762831138 0.733688858986492 0.892751661754994 0.515132353950301 2.69223728558256 0.713857624897262 1.91509730008048 2.78373856033103e-11 7.92993616222544e-10 UP ENSG00000139910 NOVA1 neuro-oncological ventral antigen 1 [Source:HGNC Symbol;Acc:HGNC:7886] GO:0032502|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0007626|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0007267|GO:0006139|GO:0007154|GO:0031323|GO:0005730|GO:0010468|GO:0003723|GO:0007417|GO:0051252|GO:0021510|GO:0031981|GO:0010467|GO:0007399|GO:0016070|GO:0005634|GO:0006396|GO:0050684|GO:0016071|GO:0044822|GO:0003729|GO:0006397|GO:0008380|GO:0007268|GO:0000375|GO:0000398 developmental process|behavior|signaling|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|locomotory behavior|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cell-cell signaling|nucleobase-containing compound metabolic process|cell communication|regulation of cellular metabolic process|nucleolus|regulation of gene expression|RNA binding|central nervous system development|regulation of RNA metabolic process|spinal cord development|nuclear lumen|gene expression|nervous system development|RNA metabolic process|nucleus|RNA processing|regulation of mRNA processing|mRNA metabolic process|poly(A) RNA binding|mRNA binding|mRNA processing|RNA splicing|synaptic transmission|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 14:26443093-26597754 38 74 67 230 259 249 0.141347631799341 0.250158298041286 0.224695239062376 0.766529061044098 0.790443621668337 0.868023115360649 0.205400389634334 0.808331932691028 -1.9765089232496 2.85022591124612e-11 8.1115962206236e-10 DOWN ENSG00000157111 TMEM171 transmembrane protein 171 [Source:HGNC Symbol;Acc:HGNC:27031] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 5:73120292-73131817 380 464 442 162 183 155 13.9130501440641 15.4396319948261 14.5906649848117 5.31437760416511 5.49740117048177 5.31861275106291 14.6477823745673 5.3767971752366 1.44586330587625 2.93717604844522e-11 8.34360198516905e-10 UP ENSG00000248360 LINC00504 long intergenic non-protein coding RNA 504 [Source:HGNC Symbol;Acc:HGNC:43555] - - - - - - 4:14470465-14888169 3 3 2 41 27 44 0.0335282494974635 0.0304727221003283 0.0201510432849016 0.410508495981383 0.247552873394995 0.46080969674117 0.0280506716275645 0.372957022039183 -3.73290217075712 2.93733693522231e-11 8.34360198516905e-10 DOWN ENSG00000127124 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 [Source:HGNC Symbol;Acc:HGNC:13561] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0061061|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010628|GO:0060537|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0007517|GO:0016070|GO:0010557|GO:0005634|GO:0060538|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0035914|GO:0014706|GO:0006351|GO:0006355|GO:0006366|GO:0007519|GO:1903506|GO:0044212 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|positive regulation of gene expression|muscle tissue development|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|muscle organ development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|skeletal muscle organ development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|skeletal muscle cell differentiation|striated muscle tissue development|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding - - - - 1:41506365-42035925 31 66 116 344 414 368 0.0835176661645515 0.161599708151226 0.281766216733606 0.830374314306012 0.915134540617872 0.92916615323231 0.175627863683128 0.891558336052065 -2.34380744947505 2.95420596853573e-11 8.3835422989226e-10 DOWN ENSG00000230091 TMEM254-AS1 TMEM254 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:27340] - - - - - - 10:80046860-80078912 1 3 3 40 67 24 0.0109342851394644 0.0298041302371876 0.0295582172146588 0.391713533074991 0.600826750468564 0.245838912131712 0.0234322108637703 0.412793065225089 -4.13885374805966 2.98308191808297e-11 8.45744801352792e-10 DOWN ENSG00000126391 FRMD8 FERM domain containing 8 [Source:HGNC Symbol;Acc:HGNC:25462] GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0005856 cell|binding|intracellular organelle|intracellular|protein binding|cytoskeleton - - - - 11:65386599-65413525 1707 1903 1850 750 887 832 14.3884403006077 14.578037175853 14.0593810497674 5.66420835317265 6.13439948904053 6.57252750188284 14.341952842076 6.12371178136534 1.22776319131462 3.00593505830332e-11 8.50608390811254e-10 UP ENSG00000198836 OPA1 optic atrophy 1 (autosomal dominant) [Source:HGNC Symbol;Acc:HGNC:8140] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0042995|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0043167|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0019867|GO:0023057|GO:0016787|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0031090|GO:0045595|GO:0051640|GO:0019866|GO:0048468|GO:0006810|GO:0051130|GO:0010941|GO:0007275|GO:0050877|GO:0016358|GO:0043168|GO:0010636|GO:0001882|GO:0051128|GO:0033554|GO:0016817|GO:0045597|GO:0043231|GO:0043169|GO:1903573|GO:0005737|GO:0005758|GO:0006928|GO:0051656|GO:0043005|GO:0009966|GO:0031966|GO:0036477|GO:0060548|GO:0010646|GO:0031314|GO:0007154|GO:0061024|GO:0010970|GO:0007165|GO:0009968|GO:0051649|GO:0008219|GO:0000166|GO:0030030|GO:0048869|GO:0016021|GO:0007017|GO:0006996|GO:0007568|GO:0030061|GO:0061025|GO:0051646|GO:0005740|GO:0031175|GO:0008053|GO:0031344|GO:0046872|GO:0035639|GO:0050773|GO:0010720|GO:0007005|GO:0043069|GO:0005741|GO:2001234|GO:0051654|GO:0001883|GO:0031346|GO:0016818|GO:0046907|GO:1902235|GO:0032549|GO:0007600|GO:0005743|GO:0007569|GO:0008088|GO:0031981|GO:0050769|GO:0030425|GO:0007018|GO:0005654|GO:0005739|GO:1902236|GO:0012501|GO:0035556|GO:0033043|GO:0007399|GO:1902532|GO:0017076|GO:0030154|GO:1900006|GO:0048469|GO:1902531|GO:0010635|GO:0072384|GO:0034976|GO:0005634|GO:0090398|GO:0043067|GO:0051960|GO:0097190|GO:0048284|GO:0007006|GO:0010638|GO:0048666|GO:0030182|GO:0000002|GO:0070059|GO:0090201|GO:0032561|GO:0050953|GO:0097193|GO:0010975|GO:0042551|GO:0019896|GO:0000266|GO:2001242|GO:0000287|GO:0047497|GO:2001243|GO:0008637|GO:0007007|GO:0010822|GO:0010823|GO:1903429|GO:0010821|GO:0001836|GO:0042981|GO:0043066|GO:0005525|GO:0022008|GO:0030705|GO:0050767|GO:0019001|GO:0016462|GO:0010976|GO:0006915|GO:0045666|GO:0014041|GO:0048699|GO:0017111|GO:0014042|GO:0007601|GO:0045664|GO:0003924 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|cell projection|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|ion binding|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|outer membrane|negative regulation of signaling|hydrolase activity|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|anatomical structure development|organelle membrane|regulation of cell differentiation|organelle localization|organelle inner membrane|cell development|transport|positive regulation of cellular component organization|regulation of cell death|multicellular organism development|neurological system process|dendrite development|anion binding|positive regulation of mitochondrial fusion|nucleoside binding|regulation of cellular component organization|cellular response to stress|hydrolase activity, acting on acid anhydrides|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|negative regulation of response to endoplasmic reticulum stress|cytoplasm|mitochondrial intermembrane space|movement of cell or subcellular component|establishment of organelle localization|neuron projection|regulation of signal transduction|mitochondrial membrane|somatodendritic compartment|negative regulation of cell death|regulation of cell communication|extrinsic component of mitochondrial inner membrane|cell communication|membrane organization|establishment of localization by movement along microtubule|signal transduction|negative regulation of signal transduction|establishment of localization in cell|cell death|nucleotide binding|cell projection organization|cellular developmental process|integral component of membrane|microtubule-based process|organelle organization|aging|mitochondrial crista|membrane fusion|mitochondrion localization|mitochondrial envelope|neuron projection development|mitochondrial fusion|regulation of cell projection organization|metal ion binding|purine ribonucleoside triphosphate binding|regulation of dendrite development|positive regulation of cell development|mitochondrion organization|negative regulation of programmed cell death|mitochondrial outer membrane|negative regulation of apoptotic signaling pathway|establishment of mitochondrion localization|purine nucleoside binding|positive regulation of cell projection organization|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|ribonucleoside binding|sensory perception|mitochondrial inner membrane|cell aging|axo-dendritic transport|nuclear lumen|positive regulation of neurogenesis|dendrite|microtubule-based movement|nucleoplasm|mitochondrion|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|programmed cell death|intracellular signal transduction|regulation of organelle organization|nervous system development|negative regulation of intracellular signal transduction|purine nucleotide binding|cell differentiation|positive regulation of dendrite development|cell maturation|regulation of intracellular signal transduction|regulation of mitochondrial fusion|organelle transport along microtubule|response to endoplasmic reticulum stress|nucleus|cellular senescence|regulation of programmed cell death|regulation of nervous system development|apoptotic signaling pathway|organelle fusion|mitochondrial membrane organization|positive regulation of organelle organization|neuron development|neuron differentiation|mitochondrial genome maintenance|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of release of cytochrome c from mitochondria|guanyl ribonucleotide binding|sensory perception of light stimulus|intrinsic apoptotic signaling pathway|regulation of neuron projection development|neuron maturation|axon transport of mitochondrion|mitochondrial fission|regulation of intrinsic apoptotic signaling pathway|magnesium ion binding|mitochondrion transport along microtubule|negative regulation of intrinsic apoptotic signaling pathway|apoptotic mitochondrial changes|inner mitochondrial membrane organization|positive regulation of mitochondrion organization|negative regulation of mitochondrion organization|regulation of cell maturation|regulation of mitochondrion organization|release of cytochrome c from mitochondria|regulation of apoptotic process|negative regulation of apoptotic process|GTP binding|neurogenesis|cytoskeleton-dependent intracellular transport|regulation of neurogenesis|guanyl nucleotide binding|pyrophosphatase activity|positive regulation of neuron projection development|apoptotic process|positive regulation of neuron differentiation|regulation of neuron maturation|generation of neurons|nucleoside-triphosphatase activity|positive regulation of neuron maturation|visual perception|regulation of neuron differentiation|GTPase activity - - - - 3:193593144-193697823 1187 1416 1562 3822 4288 3290 4.23358117707772 4.58987250756789 5.02287672228461 12.2136578253614 12.548159809788 10.9971997575681 4.61544346897674 11.9196724642392 -1.36880341397342 3.0035059269276e-11 8.50608390811254e-10 DOWN ENSG00000205903 ZNF316 zinc finger protein 316 [Source:HGNC Symbol;Acc:HGNC:13843] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 7:6637322-6656432 2022 2424 1727 782 863 856 22.5243921852094 24.5405673681278 17.3451746446127 7.8050645141782 7.88770775803039 8.93664885592398 21.47004473265 8.20980704271086 1.38690497757523 3.08602993775565e-11 8.72446380319669e-10 UP ENSG00000146350 TBC1D32 TBC1 domain family member 32 [Source:HGNC Symbol;Acc:HGNC:21485] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0051641|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0007507|GO:0060041|GO:0009888|GO:0035295|GO:0002088|GO:0007275|GO:0048513|GO:0005737|GO:0007389|GO:0007423|GO:0021915|GO:0048598|GO:0008104|GO:0007154|GO:0007165|GO:0030030|GO:0048869|GO:0000902|GO:0003406|GO:0042733|GO:0007166|GO:0001654|GO:0072358|GO:0009790|GO:0003002|GO:0021532|GO:0034613|GO:0060429|GO:0035108|GO:0032990|GO:0007399|GO:0048858|GO:0060173|GO:0072359|GO:0060271|GO:0033365|GO:0009792|GO:0021904|GO:0043010|GO:0007224|GO:0009855|GO:0009953|GO:0030326|GO:0007368|GO:0061512|GO:0060831|GO:0043009 developmental process|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|cellular localization|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|cilium|heart development|retina development in camera-type eye|tissue development|tube development|lens development in camera-type eye|multicellular organism development|animal organ development|cytoplasm|pattern specification process|sensory organ development|neural tube development|embryonic morphogenesis|protein localization|cell communication|signal transduction|cell projection organization|cellular developmental process|cell morphogenesis|retinal pigment epithelium development|embryonic digit morphogenesis|cell surface receptor signaling pathway|eye development|cardiovascular system development|embryo development|regionalization|neural tube patterning|cellular protein localization|epithelium development|limb morphogenesis|cell part morphogenesis|nervous system development|cell projection morphogenesis|limb development|circulatory system development|cilium morphogenesis|protein localization to organelle|embryo development ending in birth or egg hatching|dorsal/ventral neural tube patterning|camera-type eye development|smoothened signaling pathway|determination of bilateral symmetry|dorsal/ventral pattern formation|embryonic limb morphogenesis|determination of left/right symmetry|protein localization to cilium|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|chordate embryonic development - - - - 6:121079494-121334745 15 20 32 109 109 111 0.11746225779884 0.142338762491021 0.225930578494531 0.764783407550407 0.700338769322988 0.814639040704299 0.161910532928131 0.759920405859231 -2.23065147666414 3.09978582147656e-11 8.75506205433881e-10 DOWN ENSG00000175841 FAM172BP family with sequence similarity 172 member B, pseudogene [Source:HGNC Symbol;Acc:HGNC:34336] - - - - - - 3:101521891-101522979 26 31 30 4 3 2 1.68883278016638 1.83006133067863 1.75690983613193 0.232803866324462 0.159900423695247 0.121736906111512 1.75860131565898 0.171480398710407 3.35831287137678 3.1104937382734e-11 8.77700189625841e-10 UP ENSG00000196850 PPTC7 PTC7 protein phosphatase homolog [Source:HGNC Symbol;Acc:HGNC:30695] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0016788|GO:0043231|GO:0043169|GO:0005737|GO:0019538|GO:0046872|GO:0043412|GO:0036211|GO:0005739|GO:0006796|GO:0044267|GO:0042578|GO:0016311|GO:0016791|GO:0006464|GO:0006470|GO:0004721 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|hydrolase activity, acting on ester bonds|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein metabolic process|metal ion binding|macromolecule modification|protein modification process|mitochondrion|phosphate-containing compound metabolic process|cellular protein metabolic process|phosphoric ester hydrolase activity|dephosphorylation|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity - - - - 12:110533245-110583320 1259 1455 1537 625 695 618 14.3340893386522 15.0552352564519 15.7772889276243 6.37561861514965 6.49227535271929 6.59419577759683 15.0555378409095 6.48736324848859 1.2145901201609 3.1348230901577e-11 8.83730014481283e-10 UP ENSG00000171453 POLR1C polymerase (RNA) I polypeptide C [Source:HGNC Symbol;Acc:HGNC:20194] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0097159|GO:0009892|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0045087|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0006952|GO:0016772|GO:0046483|GO:0001817|GO:0043231|GO:0005737|GO:0001816|GO:0046983|GO:0001819|GO:0006139|GO:0044249|GO:0005730|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0032479|GO:0010629|GO:0032481|GO:0031981|GO:1990234|GO:0032606|GO:0005654|GO:0010467|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0005736|GO:0045814|GO:0032774|GO:0040029|GO:0006351|GO:0005666|GO:0006352|GO:0003899|GO:0006383|GO:0006360|GO:0006354|GO:0006353|GO:0001056|GO:0006385|GO:0006361|GO:0006362|GO:0006363|GO:0006386|GO:0001054 macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|organic cyclic compound binding|negative regulation of metabolic process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|regulation of cytokine production|intracellular membrane-bounded organelle|cytoplasm|cytokine production|protein dimerization activity|positive regulation of cytokine production|nucleobase-containing compound metabolic process|cellular biosynthetic process|nucleolus|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of type I interferon production|negative regulation of gene expression|positive regulation of type I interferon production|nuclear lumen|transferase complex|type I interferon production|nucleoplasm|gene expression|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|DNA-directed RNA polymerase I complex|negative regulation of gene expression, epigenetic|RNA biosynthetic process|regulation of gene expression, epigenetic|transcription, DNA-templated|DNA-directed RNA polymerase III complex|DNA-templated transcription, initiation|DNA-directed RNA polymerase activity|transcription from RNA polymerase III promoter|transcription from RNA polymerase I promoter|DNA-templated transcription, elongation|DNA-templated transcription, termination|RNA polymerase III activity|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|termination of RNA polymerase III transcription|RNA polymerase I activity K03027 DNA-directed RNA polymerases I and III subunit RPAC1[-] hsa01100|hsa05169|hsa00230|hsa00240|hsa04623|hsa03020 Metabolic pathways - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Cytosolic DNA-sensing pathway - Homo sapiens (human)|RNA polymerase - Homo sapiens (human) 6:43509702-43529585 1374 1300 1003 446 550 329 14.5497636579796 12.5110201199733 9.57601060150255 4.23157163015982 4.77859287600249 3.26508388960104 12.2122647931518 4.09174946525445 1.57754105855011 3.16730453105698e-11 8.92044428963916e-10 UP ENSG00000148700 ADD3 adducin 3 [Source:HGNC Symbol;Acc:HGNC:245] GO:0045202|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0005200|GO:0042995|GO:0060076|GO:0043229|GO:0005911|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0005903|GO:0006810|GO:0005938|GO:0043231|GO:0019899|GO:0005737|GO:0097481|GO:0014069|GO:0042493|GO:0005516|GO:0055085|GO:0008092|GO:0005829|GO:0003779|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0019900|GO:0005856|GO:0005634|GO:0000793|GO:0000794|GO:0019901|GO:0005080 synapse|structural molecule activity|cell|membrane|cellular process|cell junction|response to stimulus|binding|structural constituent of cytoskeleton|cell projection|excitatory synapse|intracellular organelle|cell-cell junction|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|brush border|transport|cell cortex|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|neuronal postsynaptic density|postsynaptic density|response to drug|calmodulin binding|transmembrane transport|cytoskeletal protein binding|cytosol|actin binding|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|kinase binding|cytoskeleton|nucleus|condensed chromosome|condensed nuclear chromosome|protein kinase binding|protein kinase C binding - - - - 10:109996368-110135565 307 365 718 1499 1616 2110 1.78440680935042 1.92809331828416 3.76264912598792 7.80646871044774 7.70662820017314 11.4938768625994 2.49171641787417 9.00232459107343 -1.85315769934449 3.18464830941007e-11 8.96083794807996e-10 DOWN ENSG00000077458 FAM76B family with sequence similarity 76 member B [Source:HGNC Symbol;Acc:HGNC:28492] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0008233|GO:0005635|GO:0031965|GO:0016021|GO:0019538|GO:0043412|GO:0036211|GO:0031981|GO:0006508|GO:0005654|GO:0044267|GO:0005634|GO:0016604|GO:0004175|GO:0070646|GO:0008234|GO:0006464|GO:0016607|GO:0018193|GO:0016926|GO:0018205|GO:0016929 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|peptidase activity|nuclear envelope|nuclear membrane|integral component of membrane|protein metabolic process|macromolecule modification|protein modification process|nuclear lumen|proteolysis|nucleoplasm|cellular protein metabolic process|nucleus|nuclear body|endopeptidase activity|protein modification by small protein removal|cysteine-type peptidase activity|cellular protein modification process|nuclear speck|peptidyl-amino acid modification|protein desumoylation|peptidyl-lysine modification|SUMO-specific protease activity - - - - 11:95768942-95790409 520 515 507 151 223 202 2.60485627913867 2.34459252144881 2.28982635846697 0.677725096909978 0.916544161306777 0.948333189456037 2.41309171968482 0.847534149224264 1.50953934803426 3.26875605570316e-11 9.18883646769888e-10 UP ENSG00000198648 STK39 serine/threonine kinase 39 [Source:HGNC Symbol;Acc:HGNC:17717] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0005057|GO:0071704|GO:0043167|GO:0009628|GO:0051051|GO:0044237|GO:0045177|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0019222|GO:0051726|GO:0007049|GO:0016323|GO:0006810|GO:0010941|GO:0016324|GO:0043168|GO:0006952|GO:0001882|GO:0043270|GO:0016772|GO:0031325|GO:0033554|GO:0043231|GO:0019899|GO:0005737|GO:0009611|GO:0042592|GO:0043085|GO:0007154|GO:0044092|GO:0055085|GO:0007165|GO:0007586|GO:0004702|GO:2000021|GO:0008219|GO:0006970|GO:0008217|GO:0050790|GO:0051048|GO:0000166|GO:0071804|GO:0032410|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0050878|GO:0003013|GO:0034763|GO:0043271|GO:0032268|GO:0044058|GO:0030157|GO:0035639|GO:0043412|GO:0007589|GO:0043267|GO:0050727|GO:0048878|GO:0001883|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0006811|GO:0006954|GO:0032549|GO:0032413|GO:0051046|GO:0031098|GO:0007346|GO:0071470|GO:0034766|GO:0051247|GO:0034765|GO:0016301|GO:2000681|GO:0043269|GO:0043268|GO:0019900|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0046903|GO:0017076|GO:0051246|GO:0071805|GO:0016773|GO:0008015|GO:0005856|GO:0005634|GO:0043067|GO:0022898|GO:0090188|GO:0006971|GO:0034220|GO:1901380|GO:0098655|GO:0031401|GO:1901379|GO:1901017|GO:0005524|GO:0006812|GO:0030554|GO:0016310|GO:0032412|GO:0071476|GO:0042981|GO:0050801|GO:0004672|GO:0019901|GO:2000687|GO:0006464|GO:0043549|GO:0006915|GO:0033674|GO:1901016|GO:2000680|GO:0045859|GO:0045860|GO:0043266|GO:0006468|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:0004674|GO:0030001|GO:0001934|GO:0001933|GO:0015672|GO:0042327|GO:0035826|GO:0006813|GO:0018105|GO:0018107|GO:0032147 signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|receptor signaling protein activity|organic substance metabolic process|ion binding|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|apical part of cell|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|transferase activity|regulation of metabolic process|regulation of cell cycle|cell cycle|basolateral plasma membrane|transport|regulation of cell death|apical plasma membrane|anion binding|defense response|nucleoside binding|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|response to wounding|homeostatic process|positive regulation of catalytic activity|cell communication|negative regulation of molecular function|transmembrane transport|signal transduction|digestion|receptor signaling protein serine/threonine kinase activity|regulation of ion homeostasis|cell death|response to osmotic stress|regulation of blood pressure|regulation of catalytic activity|negative regulation of secretion|nucleotide binding|cellular potassium ion transport|negative regulation of transporter activity|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|negative regulation of transmembrane transport|negative regulation of ion transport|regulation of cellular protein metabolic process|regulation of digestive system process|pancreatic juice secretion|purine ribonucleoside triphosphate binding|macromolecule modification|body fluid secretion|negative regulation of potassium ion transport|regulation of inflammatory response|chemical homeostasis|purine nucleoside binding|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|ion transport|inflammatory response|ribonucleoside binding|negative regulation of ion transmembrane transporter activity|regulation of secretion|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|cellular response to osmotic stress|negative regulation of ion transmembrane transport|positive regulation of protein metabolic process|regulation of ion transmembrane transport|kinase activity|negative regulation of rubidium ion transport|regulation of ion transport|positive regulation of potassium ion transport|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|secretion|purine nucleotide binding|regulation of protein metabolic process|potassium ion transmembrane transport|phosphotransferase activity, alcohol group as acceptor|blood circulation|cytoskeleton|nucleus|regulation of programmed cell death|regulation of transmembrane transporter activity|negative regulation of pancreatic juice secretion|hypotonic response|ion transmembrane transport|negative regulation of potassium ion transmembrane transport|cation transmembrane transport|positive regulation of protein modification process|regulation of potassium ion transmembrane transport|negative regulation of potassium ion transmembrane transporter activity|ATP binding|cation transport|adenyl nucleotide binding|phosphorylation|regulation of ion transmembrane transporter activity|cellular hypotonic response|regulation of apoptotic process|ion homeostasis|protein kinase activity|protein kinase binding|negative regulation of rubidium ion transmembrane transporter activity|cellular protein modification process|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of potassium ion transmembrane transporter activity|regulation of rubidium ion transport|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of potassium ion transport|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|protein serine/threonine kinase activity|metal ion transport|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|monovalent inorganic cation transport|positive regulation of phosphorylation|rubidium ion transport|potassium ion transport|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|activation of protein kinase activity - - - - 2:167954020-168248141 164 247 470 1063 1114 1260 2.71364547627842 3.71438457033638 7.01166864519544 15.759431608079 15.123868369937 19.5393090460198 4.47989956393675 16.8075363413453 -1.90756997538265 3.31544916199561e-11 9.31132824856227e-10 DOWN ENSG00000144655 CSRNP1 cysteine-serine-rich nuclear protein 1 [Source:HGNC Symbol;Acc:HGNC:14300] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0009791|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0060325|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0060322|GO:0009887|GO:0006139|GO:0010171|GO:0007154|GO:0007165|GO:0060323|GO:0008219|GO:0060324|GO:0044249|GO:0031323|GO:0060021|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0007166|GO:0051252|GO:0010628|GO:0012501|GO:0010467|GO:0031328|GO:0009059|GO:0001501|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0007167|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0007169|GO:0048008 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|post-embryonic development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|face morphogenesis|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|organ morphogenesis|nucleobase-containing compound metabolic process|body morphogenesis|cell communication|signal transduction|head morphogenesis|cell death|face development|cellular biosynthetic process|regulation of cellular metabolic process|palate development|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|regulation of RNA metabolic process|positive regulation of gene expression|programmed cell death|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|skeletal system development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|enzyme linked receptor protein signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transmembrane receptor protein tyrosine kinase signaling pathway|platelet-derived growth factor receptor signaling pathway - - - - 3:39141855-39154562 477 416 677 184 196 198 6.85662805498351 5.43458210002208 8.77395648322259 2.36978097345769 2.31161395892578 2.66738457021894 7.02172221274273 2.44959316753414 1.51928275874794 3.35903461416738e-11 9.41602059824911e-10 UP ENSG00000197603 C5orf42 chromosome 5 open reading frame 42 [Source:HGNC Symbol;Acc:HGNC:25801] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0051641|GO:0009653|GO:0016043|GO:0031224|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0007507|GO:0001822|GO:0009888|GO:0007164|GO:0001568|GO:0007275|GO:0048513|GO:0030902|GO:0007420|GO:0022607|GO:0060322|GO:0048729|GO:0048598|GO:0072372|GO:0008104|GO:0022037|GO:0035869|GO:0003279|GO:0030030|GO:0021549|GO:0048869|GO:0016021|GO:0060021|GO:0006996|GO:0003205|GO:0000902|GO:0042733|GO:0002009|GO:0001944|GO:0072358|GO:0007417|GO:0001655|GO:0060976|GO:0009790|GO:0001736|GO:0044782|GO:0072001|GO:0003231|GO:0030031|GO:0034613|GO:0070925|GO:0060429|GO:0042384|GO:0035108|GO:0032990|GO:0007399|GO:0048858|GO:0003281|GO:0060173|GO:0072359|GO:0031513|GO:0060271|GO:0033365|GO:0030326|GO:0001738|GO:0061512|GO:0097499|GO:1904491 developmental process|cell|membrane|cellular process|binding|cell projection|cellular localization|anatomical structure morphogenesis|cellular component organization|intrinsic component of membrane|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|heart development|kidney development|tissue development|establishment of tissue polarity|blood vessel development|multicellular organism development|animal organ development|hindbrain development|brain development|cellular component assembly|head development|tissue morphogenesis|embryonic morphogenesis|primary cilium|protein localization|metencephalon development|ciliary transition zone|cardiac septum development|cell projection organization|cerebellum development|cellular developmental process|integral component of membrane|palate development|organelle organization|cardiac chamber development|cell morphogenesis|embryonic digit morphogenesis|morphogenesis of an epithelium|vasculature development|cardiovascular system development|central nervous system development|urogenital system development|coronary vasculature development|embryo development|establishment of planar polarity|cilium organization|renal system development|cardiac ventricle development|cell projection assembly|cellular protein localization|organelle assembly|epithelium development|cilium assembly|limb morphogenesis|cell part morphogenesis|nervous system development|cell projection morphogenesis|ventricular septum development|limb development|circulatory system development|nonmotile primary cilium|cilium morphogenesis|protein localization to organelle|embryonic limb morphogenesis|morphogenesis of a polarized epithelium|protein localization to cilium|protein localization to nonmotile primary cilium|protein localization to ciliary transition zone - - - - 5:37106228-37249428 135 178 205 539 563 507 0.488313647687161 0.585147257622948 0.668548452821677 1.74683767060611 1.67086692790957 1.71871057023559 0.580669786043929 1.71213838958376 -1.56000944389134 3.35827642203395e-11 9.41602059824911e-10 DOWN ENSG00000103599 IQCH IQ motif containing H [Source:HGNC Symbol;Acc:HGNC:25721] GO:0005488|GO:0005515 binding|protein binding - - - - 15:67254800-67502260 4 7 14 63 54 69 0.0274320585410762 0.0436340449109323 0.0865709451186726 0.387127537201907 0.303866346570639 0.443502090853768 0.0525456828568937 0.378165324875438 -2.84737294164763 3.54759903459823e-11 9.93527406931477e-10 DOWN ENSG00000259623 RP11-156E6.1 - - - - - - - 17:41848518-41851447 444 483 486 168 218 134 10.7191671296454 10.5975417504602 10.5786117031256 3.63399267190306 4.31819802272666 3.03188332717428 10.6317735277437 3.661358007268 1.53793152630096 3.56997838756091e-11 9.98857870499002e-10 UP ENSG00000102606 ARHGEF7 Rho guanine nucleotide exchange factor 7 [Source:HGNC Symbol;Acc:HGNC:15607] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0030055|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0051641|GO:0048870|GO:0023051|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0031252|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0005085|GO:0048856|GO:0019222|GO:0060341|GO:0051272|GO:0006935|GO:0045595|GO:0046887|GO:0048468|GO:0043025|GO:0006810|GO:0051130|GO:0010941|GO:0005938|GO:0034446|GO:0007275|GO:0048513|GO:0005924|GO:0032940|GO:0030155|GO:0005912|GO:0051128|GO:2000147|GO:0022607|GO:0010942|GO:0051098|GO:0045597|GO:0043231|GO:0019899|GO:0005737|GO:0007267|GO:0001726|GO:0005088|GO:0006928|GO:0043005|GO:0031589|GO:0009966|GO:0030027|GO:2000394|GO:0046883|GO:0036477|GO:0010646|GO:0043085|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0045785|GO:0008219|GO:0051047|GO:0050790|GO:0030030|GO:0010817|GO:0048869|GO:2000145|GO:0010033|GO:0010256|GO:0006996|GO:0000902|GO:0005829|GO:0031175|GO:0031344|GO:0045216|GO:0007166|GO:0090276|GO:0002793|GO:1900026|GO:0007030|GO:0030097|GO:0051345|GO:0010720|GO:0031346|GO:0000904|GO:0005773|GO:0030334|GO:0001667|GO:0007160|GO:0042886|GO:0034329|GO:0051046|GO:1901184|GO:0030031|GO:0009914|GO:0051099|GO:0010810|GO:0070848|GO:0022604|GO:1901185|GO:0019900|GO:0012501|GO:0097581|GO:0035556|GO:0032990|GO:1900024|GO:0007399|GO:0046903|GO:0071310|GO:0097485|GO:0010770|GO:0010811|GO:0030154|GO:0048858|GO:0030335|GO:0005089|GO:0043068|GO:1902531|GO:0043067|GO:0005925|GO:0097190|GO:1904424|GO:0090277|GO:0043393|GO:0048666|GO:0030182|GO:0002790|GO:0007411|GO:0030032|GO:1902745|GO:0043065|GO:0010769|GO:0034332|GO:0042058|GO:0010763|GO:0072673|GO:0071363|GO:0043087|GO:0015833|GO:0038179|GO:0000322|GO:0061564|GO:0043547|GO:0007167|GO:0007044|GO:0042059|GO:0032092|GO:0010762|GO:0042981|GO:0048041|GO:0002244|GO:0060123|GO:0051056|GO:0060124|GO:0019901|GO:0022008|GO:0048667|GO:0007264|GO:0048812|GO:0046879|GO:0010761|GO:0006915|GO:2000392|GO:0034333|GO:0048011|GO:0030072|GO:0007265|GO:0046578|GO:0007409|GO:0048699|GO:0007169|GO:0030252|GO:0048013|GO:0035023|GO:0007266|GO:0038127|GO:0007173 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|cellular localization|cell motility|regulation of signaling|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|regulation of developmental process|intracellular|immune system development|protein binding|plasma membrane|protein complex|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cellular component movement|chemotaxis|regulation of cell differentiation|positive regulation of hormone secretion|cell development|neuronal cell body|transport|positive regulation of cellular component organization|regulation of cell death|cell cortex|substrate adhesion-dependent cell spreading|multicellular organism development|animal organ development|cell-substrate adherens junction|secretion by cell|regulation of cell adhesion|adherens junction|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|positive regulation of cell death|regulation of binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|cell-cell signaling|ruffle|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|neuron projection|cell-substrate adhesion|regulation of signal transduction|lamellipodium|positive regulation of lamellipodium morphogenesis|regulation of hormone secretion|somatodendritic compartment|regulation of cell communication|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|positive regulation of cell adhesion|cell death|positive regulation of secretion|regulation of catalytic activity|cell projection organization|regulation of hormone levels|cellular developmental process|regulation of cell motility|response to organic substance|endomembrane system organization|organelle organization|cell morphogenesis|cytosol|neuron projection development|regulation of cell projection organization|cell-cell junction organization|cell surface receptor signaling pathway|regulation of peptide hormone secretion|positive regulation of peptide secretion|positive regulation of substrate adhesion-dependent cell spreading|Golgi organization|hemopoiesis|positive regulation of hydrolase activity|positive regulation of cell development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|vacuole|regulation of cell migration|ameboidal-type cell migration|cell-matrix adhesion|amide transport|cell junction assembly|regulation of secretion|regulation of ERBB signaling pathway|cell projection assembly|hormone transport|positive regulation of binding|regulation of cell-substrate adhesion|response to growth factor|regulation of cell morphogenesis|negative regulation of ERBB signaling pathway|kinase binding|programmed cell death|lamellipodium organization|intracellular signal transduction|cell part morphogenesis|regulation of substrate adhesion-dependent cell spreading|nervous system development|secretion|cellular response to organic substance|neuron projection guidance|positive regulation of cell morphogenesis involved in differentiation|positive regulation of cell-substrate adhesion|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|regulation of programmed cell death|focal adhesion|apoptotic signaling pathway|regulation of GTP binding|positive regulation of peptide hormone secretion|regulation of protein binding|neuron development|neuron differentiation|peptide secretion|axon guidance|lamellipodium assembly|positive regulation of lamellipodium organization|positive regulation of apoptotic process|regulation of cell morphogenesis involved in differentiation|adherens junction organization|regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast migration|lamellipodium morphogenesis|cellular response to growth factor stimulus|regulation of GTPase activity|peptide transport|neurotrophin signaling pathway|storage vacuole|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|cell-substrate junction assembly|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of protein binding|regulation of fibroblast migration|regulation of apoptotic process|focal adhesion assembly|hematopoietic progenitor cell differentiation|regulation of growth hormone secretion|regulation of small GTPase mediated signal transduction|positive regulation of growth hormone secretion|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|neuron projection morphogenesis|hormone secretion|fibroblast migration|apoptotic process|regulation of lamellipodium morphogenesis|adherens junction assembly|neurotrophin TRK receptor signaling pathway|peptide hormone secretion|Ras protein signal transduction|regulation of Ras protein signal transduction|axonogenesis|generation of neurons|transmembrane receptor protein tyrosine kinase signaling pathway|growth hormone secretion|ephrin receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K13710 Rho guanine nucleotide exchange factor 7[-] hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) 13:111114559-111305737 251 300 471 1019 1102 947 0.780163132166739 0.847446639586996 1.31991804571509 2.83781267449956 2.81035544235931 2.75861230111363 0.982509272489608 2.80226013932417 -1.51204796213744 3.57333726083936e-11 9.9886152233238e-10 DOWN ENSG00000118965 WDR35 WD repeat domain 35 [Source:HGNC Symbol;Acc:HGNC:29250] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0043229|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0008289|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0006810|GO:0005930|GO:0043168|GO:0030990|GO:0005543|GO:0022607|GO:0006928|GO:0030991|GO:0045184|GO:0072372|GO:0036064|GO:0008104|GO:0010970|GO:0051649|GO:0097542|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0005813|GO:0035091|GO:0005815|GO:0015031|GO:0044782|GO:0046907|GO:0030031|GO:0007018|GO:0034613|GO:0070925|GO:0042384|GO:0032990|GO:0031503|GO:0048858|GO:0005856|GO:0060271|GO:0033365|GO:0042073|GO:0006886|GO:0015630|GO:0030705|GO:0061512|GO:0035721 developmental process|macromolecular complex|cell|cellular process|binding|cell projection|intracellular organelle|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|lipid binding|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|transport|axoneme|anion binding|intraciliary transport particle|phospholipid binding|cellular component assembly|movement of cell or subcellular component|intraciliary transport particle A|establishment of protein localization|primary cilium|ciliary basal body|protein localization|establishment of localization by movement along microtubule|establishment of localization in cell|ciliary tip|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|centrosome|phosphatidylinositol binding|microtubule organizing center|protein transport|cilium organization|intracellular transport|cell projection assembly|microtubule-based movement|cellular protein localization|organelle assembly|cilium assembly|cell part morphogenesis|protein complex localization|cell projection morphogenesis|cytoskeleton|cilium morphogenesis|protein localization to organelle|intraciliary transport|intracellular protein transport|microtubule cytoskeleton|cytoskeleton-dependent intracellular transport|protein localization to cilium|intraciliary retrograde transport - - - - 2:19910260-19990131 59 81 64 275 283 230 0.451769416141371 0.563682820205943 0.441833928456613 1.8866773483292 1.77796087917319 1.65053316617623 0.485762054934642 1.77172379789287 -1.86683200903905 3.58066148238999e-11 9.99972571517969e-10 DOWN ENSG00000168843 FSTL5 follistatin-like 5 [Source:HGNC Symbol;Acc:HGNC:21386] GO:0005576|GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0005509 extracellular region|binding|ion binding|protein binding|cation binding|metal ion binding|calcium ion binding - - - - 4:161383897-162164035 81 67 158 327 688 562 0.601103312323899 0.451875751568981 1.05714070730862 2.17424103663538 4.18907244412519 3.90864907761268 0.703373257067167 3.42398751945775 -2.28331505462471 3.58539257914538e-11 1.00035803792342e-09 DOWN ENSG00000143013 LMO4 LIM domain only 4 [Source:HGNC Symbol;Acc:HGNC:6644] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0021517|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0043169|GO:0005667|GO:0001775|GO:0021915|GO:0048729|GO:0048598|GO:0006139|GO:0050865|GO:0035148|GO:0003279|GO:0008134|GO:0048869|GO:0044249|GO:0021516|GO:0043254|GO:0031323|GO:0048732|GO:0003205|GO:0003677|GO:0031333|GO:0048538|GO:0010468|GO:0034645|GO:0010453|GO:0046872|GO:0002009|GO:0072358|GO:0007417|GO:0051252|GO:0021510|GO:0009790|GO:0010628|GO:0072175|GO:0021527|GO:0016331|GO:0003231|GO:0001708|GO:0021514|GO:0006461|GO:0001841|GO:0060429|GO:0010467|GO:0007399|GO:0060562|GO:0031328|GO:0009059|GO:0030154|GO:0060606|GO:0003281|GO:0016070|GO:0072359|GO:0021522|GO:0010557|GO:0045165|GO:0030182|GO:0021953|GO:0000975|GO:0045893|GO:0009792|GO:0001843|GO:0032774|GO:0043565|GO:2001141|GO:0001838|GO:0021515|GO:0003690|GO:0042659|GO:0046914|GO:0022008|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0043009|GO:0008270|GO:0035326|GO:0000976|GO:0001158 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|ventral spinal cord development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|cation binding|transcription factor complex|cell activation|neural tube development|tissue morphogenesis|embryonic morphogenesis|nucleobase-containing compound metabolic process|regulation of cell activation|tube formation|cardiac septum development|transcription factor binding|cellular developmental process|cellular biosynthetic process|dorsal spinal cord development|regulation of protein complex assembly|regulation of cellular metabolic process|gland development|cardiac chamber development|DNA binding|negative regulation of protein complex assembly|thymus development|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of cell fate commitment|metal ion binding|morphogenesis of an epithelium|cardiovascular system development|central nervous system development|regulation of RNA metabolic process|spinal cord development|embryo development|positive regulation of gene expression|epithelial tube formation|spinal cord association neuron differentiation|morphogenesis of embryonic epithelium|cardiac ventricle development|cell fate specification|ventral spinal cord interneuron differentiation|protein complex assembly|neural tube formation|epithelium development|gene expression|nervous system development|epithelial tube morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|tube closure|ventricular septum development|RNA metabolic process|circulatory system development|spinal cord motor neuron differentiation|positive regulation of macromolecule biosynthetic process|cell fate commitment|neuron differentiation|central nervous system neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|neural tube closure|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|embryonic epithelial tube formation|cell differentiation in spinal cord|double-stranded DNA binding|regulation of cell fate specification|transition metal ion binding|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|zinc ion binding|enhancer binding|transcription regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding - - - - 1:87328468-87348923 108 129 135 474 439 352 1.07584229026142 1.16787669241766 1.21247759474979 4.23060107650288 3.58805407331113 3.28623349901051 1.15206552580962 3.70162954960817 -1.68393774589867 3.60301145079329e-11 1.00433523671319e-09 DOWN ENSG00000146802 TMEM168 transmembrane protein 168 [Source:HGNC Symbol;Acc:HGNC:25826] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0031982|GO:0043231|GO:0030133|GO:0005737|GO:0016021|GO:0031410|GO:0016023|GO:0031988 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|vesicle|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|integral component of membrane|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle - - - - 7:112762382-112790592 17 9 48 187 241 164 0.104402127156907 0.0502358172746567 0.265782231940312 1.02898095755338 1.21437690810383 0.943931416930318 0.140140058790625 1.06242976086251 -2.92242615355896 3.612710773748e-11 1.00609950969657e-09 DOWN ENSG00000218305 CDC14C cell division cycle 14C [Source:HGNC Symbol;Acc:HGNC:22427] - - - - - - 7:48919765-48926013 0 2 5 36 27 37 0 0.0747961629773932 0.185489753232518 1.32731039885631 0.911582134142127 1.42690788014961 0.0867619720699704 1.22193347104935 -3.81595908326581 3.69843149270788e-11 1.029011871233e-09 DOWN ENSG00000168734 PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma [Source:HGNC Symbol;Acc:HGNC:9019] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0043227|GO:1903828|GO:0009058|GO:0030234|GO:0005622|GO:0019222|GO:0060341|GO:0051726|GO:0007049|GO:1900181|GO:0004857|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0032880|GO:0045184|GO:0009890|GO:0032387|GO:0006139|GO:0008104|GO:0007154|GO:0044092|GO:0007165|GO:0051649|GO:0090317|GO:0050790|GO:0019207|GO:0043086|GO:0044249|GO:0019538|GO:0051224|GO:0031324|GO:0031323|GO:0032268|GO:0019210|GO:0010468|GO:0034645|GO:0042308|GO:0043412|GO:0072594|GO:0010629|GO:0019887|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0036211|GO:0032269|GO:0070201|GO:0046907|GO:0034613|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0017038|GO:0051246|GO:0009059|GO:1903827|GO:0016070|GO:0005634|GO:0006606|GO:1904589|GO:0033365|GO:0033157|GO:0051169|GO:0045892|GO:0032774|GO:2001141|GO:0016310|GO:0006605|GO:1902679|GO:1904030|GO:0016482|GO:0006886|GO:0004860|GO:0033673|GO:0042306|GO:1900180|GO:0006464|GO:0043549|GO:0006351|GO:0006355|GO:0030291|GO:1903533|GO:0006366|GO:0006913|GO:0045859|GO:1903507|GO:0006469|GO:0006357|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0042326|GO:0001933|GO:0000122|GO:0034504|GO:0046822|GO:0051170|GO:0071901|GO:0071900|GO:0004862|GO:2000480|GO:2000479 signaling|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|membrane-bounded organelle|negative regulation of cellular protein localization|biosynthetic process|enzyme regulator activity|intracellular|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|cell cycle|negative regulation of protein localization to nucleus|enzyme inhibitor activity|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|establishment of protein localization|negative regulation of biosynthetic process|negative regulation of intracellular transport|nucleobase-containing compound metabolic process|protein localization|cell communication|negative regulation of molecular function|signal transduction|establishment of localization in cell|negative regulation of intracellular protein transport|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|kinase inhibitor activity|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of protein import into nucleus|macromolecule modification|establishment of protein localization to organelle|negative regulation of gene expression|protein kinase regulator activity|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|protein modification process|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|intracellular transport|cellular protein localization|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|protein import|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of cellular protein localization|RNA metabolic process|nucleus|protein import into nucleus|regulation of protein import|protein localization to organelle|regulation of intracellular protein transport|nuclear transport|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorylation|protein targeting|negative regulation of RNA biosynthetic process|negative regulation of cyclin-dependent protein kinase activity|cytosolic transport|intracellular protein transport|protein kinase inhibitor activity|negative regulation of kinase activity|regulation of protein import into nucleus|regulation of protein localization to nucleus|cellular protein modification process|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|protein serine/threonine kinase inhibitor activity|regulation of protein targeting|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|negative regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|cAMP-dependent protein kinase inhibitor activity|negative regulation of cAMP-dependent protein kinase activity|regulation of cAMP-dependent protein kinase activity - - - - 20:44531785-44624247 60 61 86 227 264 280 1.3585827656007 1.25529956833582 1.75569109315297 4.60530494723468 4.90463068133504 5.94184883435478 1.4565244756965 5.15059482097483 -1.82220910783723 4.00484664496967e-11 1.11322804226187e-09 DOWN ENSG00000125971 DYNLRB1 dynein, light chain, roadblock-type 1 [Source:HGNC Symbol;Acc:HGNC:15468] GO:0032991|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0042995|GO:0043229|GO:0009628|GO:0016043|GO:0044708|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0005929|GO:0009314|GO:0006810|GO:0005874|GO:0016817|GO:0007632|GO:0005737|GO:0006928|GO:0072372|GO:0005875|GO:0097542|GO:0007017|GO:0006996|GO:0005813|GO:0005815|GO:0016818|GO:0007018|GO:0030286|GO:0005856|GO:0009416|GO:0015630|GO:0005868|GO:0016462|GO:0017111|GO:0003774|GO:0003777 macromolecular complex|behavior|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cell projection|intracellular organelle|response to abiotic stimulus|cellular component organization|single-organism behavior|hydrolase activity|intracellular|protein binding|protein complex|cilium|response to radiation|transport|microtubule|hydrolase activity, acting on acid anhydrides|visual behavior|cytoplasm|movement of cell or subcellular component|primary cilium|microtubule associated complex|ciliary tip|microtubule-based process|organelle organization|centrosome|microtubule organizing center|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|microtubule-based movement|dynein complex|cytoskeleton|response to light stimulus|microtubule cytoskeleton|cytoplasmic dynein complex|pyrophosphatase activity|nucleoside-triphosphatase activity|motor activity|microtubule motor activity - - - - 20:34516409-34540958 257 274 314 809 892 702 6.2343463441494 6.04071356984398 6.8675494993615 17.5834741516838 17.7537799334373 15.9596866068043 6.38086980445163 17.0989802306418 -1.42208528389125 4.02527978312179e-11 1.11786700135179e-09 DOWN ENSG00000059769 DNAJC25 DnaJ heat shock protein family (Hsp40) member C25 [Source:HGNC Symbol;Acc:HGNC:34187] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 9:111631352-111654351 1121 1113 781 355 437 345 17.2120689271884 15.5311175359188 10.8116685514511 4.88375630909221 5.50525366632572 4.96450474106343 14.5182850048528 5.11783823882712 1.50426458930735 4.03337401820432e-11 1.11907386560847e-09 UP ENSG00000078018 MAP2 microtubule associated protein 2 [Source:HGNC Symbol;Acc:HGNC:6839] GO:0032502|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0044877|GO:0043229|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048468|GO:0007275|GO:0016358|GO:0005874|GO:0043231|GO:0005737|GO:0032403|GO:0043005|GO:0005875|GO:0005516|GO:0008092|GO:0030030|GO:0001948|GO:0048869|GO:0007017|GO:0006996|GO:0005730|GO:0015631|GO:0000902|GO:0031175|GO:0007010|GO:0007417|GO:0048813|GO:0000904|GO:0008017|GO:0031981|GO:0032990|GO:0007399|GO:0002162|GO:0030154|GO:0048858|GO:0000226|GO:0005856|GO:0005634|GO:0048666|GO:0030182|GO:0021953|GO:0015630|GO:0021954|GO:0001578|GO:0022008|GO:0048667|GO:0048812|GO:0048699 developmental process|macromolecular complex|structural molecule activity|cell|cellular process|binding|cell projection|macromolecular complex binding|intracellular organelle|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|anatomical structure development|cell development|multicellular organism development|dendrite development|microtubule|intracellular membrane-bounded organelle|cytoplasm|protein complex binding|neuron projection|microtubule associated complex|calmodulin binding|cytoskeletal protein binding|cell projection organization|glycoprotein binding|cellular developmental process|microtubule-based process|organelle organization|nucleolus|tubulin binding|cell morphogenesis|neuron projection development|cytoskeleton organization|central nervous system development|dendrite morphogenesis|cell morphogenesis involved in differentiation|microtubule binding|nuclear lumen|cell part morphogenesis|nervous system development|dystroglycan binding|cell differentiation|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|nucleus|neuron development|neuron differentiation|central nervous system neuron differentiation|microtubule cytoskeleton|central nervous system neuron development|microtubule bundle formation|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|generation of neurons - - - - 2:209424058-209734118 2 9 29 112 170 154 0.006903529469858 0.0282361967289428 0.0902562040663587 0.346398546706876 0.48148086233007 0.498207792781369 0.0417986434217198 0.442029067272772 -3.40261321714166 4.31338857630075e-11 1.19565369133596e-09 DOWN ENSG00000108684 ASIC2 acid sensing ion channel subunit 2 [Source:HGNC Symbol;Acc:HGNC:99] GO:0032502|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0022857|GO:0048523|GO:0051606|GO:0050794|GO:0006950|GO:0044089|GO:0071704|GO:0009628|GO:0044297|GO:0016043|GO:0071944|GO:0009605|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0050817|GO:0042391|GO:0043025|GO:0009314|GO:0006810|GO:0051130|GO:0009612|GO:0010941|GO:0007275|GO:0050877|GO:0051128|GO:0022607|GO:0009582|GO:0050803|GO:0005887|GO:0007267|GO:0009611|GO:0051963|GO:0043005|GO:0043197|GO:0036477|GO:0022891|GO:0060548|GO:0031226|GO:0009268|GO:0008104|GO:0050906|GO:0007154|GO:0055085|GO:0007165|GO:0051965|GO:0050808|GO:0008219|GO:0008217|GO:0016021|GO:0050878|GO:0003013|GO:0035150|GO:0010468|GO:0030193|GO:0007416|GO:0009583|GO:0050807|GO:0044309|GO:0007417|GO:0043069|GO:0007596|GO:0001976|GO:0042060|GO:0015267|GO:0006811|GO:0007602|GO:0015075|GO:0007600|GO:0010447|GO:0007599|GO:0030425|GO:0034765|GO:0035418|GO:0043269|GO:0050982|GO:0012501|GO:0050974|GO:0010467|GO:0007399|GO:0008015|GO:0009416|GO:0043067|GO:0051960|GO:0003073|GO:0007422|GO:0034220|GO:0015276|GO:0003026|GO:0098655|GO:0005216|GO:0050954|GO:0006812|GO:0019229|GO:0042981|GO:0043066|GO:0007606|GO:0003025|GO:0006915|GO:0008324|GO:0050880|GO:0061041|GO:0050909|GO:0015280|GO:0007605|GO:0042310|GO:0022890|GO:0030001|GO:0005261|GO:0022839|GO:0015672|GO:0007268|GO:0005272|GO:0035725|GO:0006814|GO:0050915|GO:0015077|GO:0046873|GO:0015081 developmental process|transporter activity|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|transmembrane transporter activity|negative regulation of cellular process|detection of stimulus|regulation of cellular process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|response to abiotic stimulus|cell body|cellular component organization|cell periphery|response to external stimulus|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|coagulation|regulation of membrane potential|neuronal cell body|response to radiation|transport|positive regulation of cellular component organization|response to mechanical stimulus|regulation of cell death|multicellular organism development|neurological system process|regulation of cellular component organization|cellular component assembly|detection of abiotic stimulus|regulation of synapse structure or activity|integral component of plasma membrane|cell-cell signaling|response to wounding|regulation of synapse assembly|neuron projection|dendritic spine|somatodendritic compartment|substrate-specific transmembrane transporter activity|negative regulation of cell death|intrinsic component of plasma membrane|response to pH|protein localization|detection of stimulus involved in sensory perception|cell communication|transmembrane transport|signal transduction|positive regulation of synapse assembly|synapse organization|cell death|regulation of blood pressure|integral component of membrane|regulation of body fluid levels|circulatory system process|regulation of tube size|regulation of gene expression|regulation of blood coagulation|synapse assembly|detection of light stimulus|regulation of synapse organization|neuron spine|central nervous system development|negative regulation of programmed cell death|blood coagulation|neurological system process involved in regulation of systemic arterial blood pressure|wound healing|channel activity|ion transport|phototransduction|ion transmembrane transporter activity|sensory perception|response to acidic pH|hemostasis|dendrite|regulation of ion transmembrane transport|protein localization to synapse|regulation of ion transport|detection of mechanical stimulus|programmed cell death|detection of mechanical stimulus involved in sensory perception|gene expression|nervous system development|blood circulation|response to light stimulus|regulation of programmed cell death|regulation of nervous system development|regulation of systemic arterial blood pressure|peripheral nervous system development|ion transmembrane transport|ligand-gated ion channel activity|regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback|cation transmembrane transport|ion channel activity|sensory perception of mechanical stimulus|cation transport|regulation of vasoconstriction|regulation of apoptotic process|negative regulation of apoptotic process|sensory perception of chemical stimulus|regulation of systemic arterial blood pressure by baroreceptor feedback|apoptotic process|cation transmembrane transporter activity|regulation of blood vessel size|regulation of wound healing|sensory perception of taste|ligand-gated sodium channel activity|sensory perception of sound|vasoconstriction|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|ion gated channel activity|monovalent inorganic cation transport|synaptic transmission|sodium channel activity|sodium ion transmembrane transport|sodium ion transport|sensory perception of sour taste|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|sodium ion transmembrane transporter activity K04828 acid-sensing ion channel 2[-] hsa04750|hsa04742 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Taste transduction - Homo sapiens (human) 17:33013087-34174964 0 4 4 28 35 39 0 0.0422248289517698 0.0418903461390565 0.291395690439955 0.333553554223044 0.424547890555503 0.0280383916969421 0.349832378406167 -3.64118831994834 4.32297025196151e-11 1.19719808814526e-09 DOWN ENSG00000135525 MAP7 microtubule associated protein 7 [Source:HGNC Symbol;Acc:HGNC:6869] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0043229|GO:0006950|GO:0009628|GO:0051641|GO:0016043|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016323|GO:0005102|GO:0005874|GO:0005737|GO:0005875|GO:0008104|GO:0007163|GO:0061024|GO:0006970|GO:0007017|GO:0010256|GO:0006996|GO:0007010|GO:0007009|GO:0072657|GO:0048471|GO:0034613|GO:0000226|GO:0005856|GO:0072659|GO:0015630|GO:1990778 macromolecular complex|structural molecule activity|cell|membrane|cellular process|response to stimulus|binding|intracellular organelle|response to stress|response to abiotic stimulus|cellular localization|cellular component organization|cell periphery|intracellular|protein binding|plasma membrane|protein complex|basolateral plasma membrane|receptor binding|microtubule|cytoplasm|microtubule associated complex|protein localization|establishment or maintenance of cell polarity|membrane organization|response to osmotic stress|microtubule-based process|endomembrane system organization|organelle organization|cytoskeleton organization|plasma membrane organization|protein localization to membrane|perinuclear region of cytoplasm|cellular protein localization|microtubule cytoskeleton organization|cytoskeleton|protein localization to plasma membrane|microtubule cytoskeleton|protein localization to cell periphery - - - - 6:136342281-136550819 185 225 382 746 955 927 1.36586354497704 1.50972480873067 2.54280504410405 4.93482027861367 5.7850366712552 6.41421274302666 1.80613113260392 5.71135656429851 -1.66093081368635 4.35737514299078e-11 1.20560776199117e-09 DOWN ENSG00000108963 DPH1 diphthamide biosynthesis 1 [Source:HGNC Symbol;Acc:HGNC:3003] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0008283|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0017183|GO:0044249|GO:0019538|GO:0005829|GO:0043412|GO:0036211|GO:0044267|GO:0005634|GO:0006464|GO:0018193|GO:0043687 cell|cellular process|metabolic process|binding|cell proliferation|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|peptidyl-diphthamide biosynthetic process from peptidyl-histidine|cellular biosynthetic process|protein metabolic process|cytosol|macromolecule modification|protein modification process|cellular protein metabolic process|nucleus|cellular protein modification process|peptidyl-amino acid modification|post-translational protein modification - - - - 17:2030110-2043430 1075 1249 1166 503 572 522 5.80164226215331 6.12611059515766 5.67355404943233 2.4322507752147 2.53283056420715 2.64023278596885 5.86710230224777 2.53510470846357 1.21060281122733 4.47791003439892e-11 1.23781042747172e-09 UP ENSG00000132510 KDM6B lysine (K)-specific demethylase 6B [Source:HGNC Symbol;Acc:HGNC:29012] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0014823|GO:0032451|GO:0044877|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0006725|GO:0009888|GO:0008013|GO:0051213|GO:0021766|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0034641|GO:0032452|GO:0006952|GO:0030900|GO:0031325|GO:0046483|GO:0033554|GO:0006482|GO:0007420|GO:0061061|GO:0043231|GO:0002437|GO:0043169|GO:0060322|GO:0048729|GO:0048598|GO:0070988|GO:0003682|GO:0006979|GO:0006139|GO:0001704|GO:0021543|GO:0048869|GO:0010035|GO:0021537|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0055114|GO:0009636|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0072358|GO:0060992|GO:0007417|GO:0042542|GO:0007498|GO:0042692|GO:0071558|GO:0051252|GO:0006325|GO:0035051|GO:0048738|GO:0021761|GO:0009790|GO:0010628|GO:0036211|GO:0060537|GO:0007369|GO:0006954|GO:0001707|GO:0031981|GO:0034599|GO:0005654|GO:0016577|GO:0060429|GO:0000302|GO:0044267|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0048332|GO:0045165|GO:0003158|GO:0045893|GO:0030855|GO:0032774|GO:0043565|GO:0048333|GO:2001141|GO:0070076|GO:0051146|GO:0016568|GO:0034614|GO:0014706|GO:0055007|GO:0006464|GO:0006351|GO:0070301|GO:0006355|GO:0045944|GO:0045446|GO:0006366|GO:0006357|GO:1903506|GO:0071557 developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|response to activity|demethylase activity|macromolecular complex binding|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|cellular aromatic compound metabolic process|tissue development|beta-catenin binding|dioxygenase activity|hippocampus development|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|histone demethylase activity|defense response|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|protein demethylation|brain development|muscle structure development|intracellular membrane-bounded organelle|inflammatory response to antigenic stimulus|cation binding|head development|tissue morphogenesis|embryonic morphogenesis|demethylation|chromatin binding|response to oxidative stress|nucleobase-containing compound metabolic process|formation of primary germ layer|pallium development|cellular developmental process|response to inorganic substance|telencephalon development|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|response to toxic substance|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|cardiovascular system development|response to fungicide|central nervous system development|response to hydrogen peroxide|mesoderm development|muscle cell differentiation|histone demethylase activity (H3-K27 specific)|regulation of RNA metabolic process|chromatin organization|cardiocyte differentiation|cardiac muscle tissue development|limbic system development|embryo development|positive regulation of gene expression|protein modification process|muscle tissue development|gastrulation|inflammatory response|mesoderm formation|nuclear lumen|cellular response to oxidative stress|nucleoplasm|histone demethylation|epithelium development|response to reactive oxygen species|cellular protein metabolic process|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|mesoderm morphogenesis|cell fate commitment|endothelium development|positive regulation of transcription, DNA-templated|epithelial cell differentiation|RNA biosynthetic process|sequence-specific DNA binding|mesodermal cell differentiation|regulation of RNA biosynthetic process|histone lysine demethylation|striated muscle cell differentiation|chromatin modification|cellular response to reactive oxygen species|striated muscle tissue development|cardiac muscle cell differentiation|cellular protein modification process|transcription, DNA-templated|cellular response to hydrogen peroxide|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|histone H3-K27 demethylation - - - - 17:7839904-7854796 1378 1616 2170 556 674 829 12.1328548029744 12.9310930866826 17.2261349790598 4.38617572857496 4.86901942734802 6.84065142639627 14.0966942895723 5.36528219410642 1.39363092811159 4.54782482646181e-11 1.25597374994626e-09 UP ENSG00000185924 RTN4RL1 reticulon 4 receptor-like 1 [Source:HGNC Symbol;Acc:HGNC:21329] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0009986|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0031224|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0031225|GO:0051726|GO:0007049|GO:0004857|GO:0009897|GO:0048468|GO:0007275|GO:0046658|GO:0031982|GO:0033554|GO:0005737|GO:0009611|GO:0009966|GO:0010646|GO:0031226|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0070062|GO:0050790|GO:0030030|GO:0019207|GO:0043086|GO:0048869|GO:0019538|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0032268|GO:0031175|GO:0019210|GO:0007166|GO:0031102|GO:0043412|GO:0034097|GO:0019887|GO:0048678|GO:0036211|GO:0032269|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0007399|GO:0071310|GO:1902532|GO:0051246|GO:0030154|GO:0045121|GO:1902531|GO:0048666|GO:0030182|GO:0019221|GO:0016310|GO:1904030|GO:0061564|GO:0004860|GO:0071345|GO:0033673|GO:0022008|GO:0006464|GO:0031103|GO:0043549|GO:0007259|GO:0045859|GO:0006469|GO:0006468|GO:0048699|GO:0046425|GO:0042325|GO:0046426|GO:0001932|GO:0042326|GO:0001933 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|cell surface|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|intrinsic component of membrane|enzyme regulator activity|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|anchored component of membrane|regulation of cell cycle|cell cycle|enzyme inhibitor activity|external side of plasma membrane|cell development|multicellular organism development|anchored component of plasma membrane|vesicle|cellular response to stress|cytoplasm|response to wounding|regulation of signal transduction|regulation of cell communication|intrinsic component of plasma membrane|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|extracellular exosome|regulation of catalytic activity|cell projection organization|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|protein metabolic process|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|neuron projection development|kinase inhibitor activity|cell surface receptor signaling pathway|neuron projection regeneration|macromolecule modification|response to cytokine|protein kinase regulator activity|response to axon injury|protein modification process|negative regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|membrane raft|regulation of intracellular signal transduction|neuron development|neuron differentiation|cytokine-mediated signaling pathway|phosphorylation|negative regulation of cyclin-dependent protein kinase activity|axon development|protein kinase inhibitor activity|cellular response to cytokine stimulus|negative regulation of kinase activity|neurogenesis|cellular protein modification process|axon regeneration|regulation of kinase activity|JAK-STAT cascade|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|generation of neurons|regulation of JAK-STAT cascade|regulation of phosphorylation|negative regulation of JAK-STAT cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation - - - - 17:1934677-2025345 38 47 59 170 194 257 0.741519424531881 0.833526516517003 1.03801515731738 2.97223730590059 3.10603695394593 4.7000143626443 0.871020366122088 3.59276287416361 -2.04431536190889 4.73841469606568e-11 1.30739955948563e-09 DOWN ENSG00000177830 CHID1 chitinase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28474] GO:0002376|GO:0005623|GO:0016020|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0006955|GO:0030246|GO:0043227|GO:0009605|GO:0016787|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0002532|GO:0001818|GO:0045087|GO:0070492|GO:0016798|GO:0006952|GO:0031982|GO:0001817|GO:0043231|GO:0005737|GO:0001816|GO:0009611|GO:0005975|GO:0008061|GO:0070062|GO:0005794|GO:0005768|GO:0005802|GO:1900016|GO:0050727|GO:0005773|GO:0006954|GO:0006040|GO:0005770|GO:0050728|GO:0004553|GO:1900015|GO:0005634|GO:0002534|GO:0000323|GO:0006030|GO:0004568|GO:0006032|GO:0005764 immune system process|cell|membrane|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|immune response|carbohydrate binding|membrane-bounded organelle|response to external stimulus|hydrolase activity|extracellular space|intracellular|protein binding|endomembrane system|production of molecular mediator involved in inflammatory response|negative regulation of cytokine production|innate immune response|oligosaccharide binding|hydrolase activity, acting on glycosyl bonds|defense response|vesicle|regulation of cytokine production|intracellular membrane-bounded organelle|cytoplasm|cytokine production|response to wounding|carbohydrate metabolic process|chitin binding|extracellular exosome|Golgi apparatus|endosome|trans-Golgi network|negative regulation of cytokine production involved in inflammatory response|regulation of inflammatory response|vacuole|inflammatory response|amino sugar metabolic process|late endosome|negative regulation of inflammatory response|hydrolase activity, hydrolyzing O-glycosyl compounds|regulation of cytokine production involved in inflammatory response|nucleus|cytokine production involved in inflammatory response|lytic vacuole|chitin metabolic process|chitinase activity|chitin catabolic process|lysosome - - - - 11:867860-915058 227 255 324 788 814 702 1.19322886156987 1.21819814630457 1.53552462362379 3.71126140898213 3.51066854872463 3.45830765738586 1.31565054383274 3.56007920503087 -1.43613299988681 4.79688500363349e-11 1.32231029453808e-09 DOWN ENSG00000104133 SPG11 spastic paraplegia 11 (autosomal recessive) [Source:HGNC Symbol;Acc:HGNC:11226] GO:0032502|GO:0040007|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0042995|GO:0043229|GO:0016049|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0031090|GO:0048468|GO:0006810|GO:0007275|GO:0031982|GO:0043231|GO:0005774|GO:0005737|GO:0006928|GO:0043005|GO:0036477|GO:0010970|GO:0048588|GO:0070062|GO:0051649|GO:0030030|GO:0048869|GO:0016021|GO:0007017|GO:0060560|GO:0005730|GO:0000902|GO:0005829|GO:0031175|GO:0030424|GO:0031410|GO:0000904|GO:0005773|GO:0046907|GO:0008088|GO:0031981|GO:0030425|GO:0007018|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0005634|GO:1990138|GO:0048666|GO:0030182|GO:0000323|GO:0061564|GO:0022008|GO:0048667|GO:0030705|GO:0048812|GO:0005765|GO:0048675|GO:0007409|GO:0005764|GO:0048699 developmental process|growth|synapse|cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|cell projection|intracellular organelle|cell growth|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|organelle membrane|cell development|transport|multicellular organism development|vesicle|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|movement of cell or subcellular component|neuron projection|somatodendritic compartment|establishment of localization by movement along microtubule|developmental cell growth|extracellular exosome|establishment of localization in cell|cell projection organization|cellular developmental process|integral component of membrane|microtubule-based process|developmental growth involved in morphogenesis|nucleolus|cell morphogenesis|cytosol|neuron projection development|axon|cytoplasmic vesicle|cell morphogenesis involved in differentiation|vacuole|intracellular transport|axo-dendritic transport|nuclear lumen|dendrite|microtubule-based movement|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|nucleus|neuron projection extension|neuron development|neuron differentiation|lytic vacuole|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|cytoskeleton-dependent intracellular transport|neuron projection morphogenesis|lysosomal membrane|axon extension|axonogenesis|lysosome|generation of neurons - - - - 15:44562696-44663678 190 223 426 884 954 1108 0.665411095588248 0.709778135869411 1.34511911668031 2.77387930865891 2.74128286172199 3.63668895795694 0.906769449379323 3.05061704277928 -1.75029339336676 4.80498484566608e-11 1.32332119541066e-09 DOWN ENSG00000054282 SDCCAG8 serologically defined colon cancer antigen 8 [Source:HGNC Symbol;Acc:HGNC:10671] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0030054|GO:0005488|GO:0043229|GO:0048870|GO:0005911|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0007049|GO:0035239|GO:0022402|GO:0035295|GO:0007275|GO:0005737|GO:0006928|GO:0007163|GO:0035148|GO:0016477|GO:0048869|GO:0007017|GO:0006996|GO:0031023|GO:0005829|GO:0005813|GO:1903047|GO:0007010|GO:0005815|GO:0044770|GO:0005814|GO:0000278|GO:0001764|GO:0030010|GO:0007399|GO:0030154|GO:0000226|GO:0005856|GO:0000086|GO:0044772|GO:0015630|GO:0051297|GO:0034451|GO:0022008|GO:0048699 locomotion|developmental process|cell|cellular process|cell junction|binding|intracellular organelle|cell motility|cell-cell junction|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|cell cycle|tube morphogenesis|cell cycle process|tube development|multicellular organism development|cytoplasm|movement of cell or subcellular component|establishment or maintenance of cell polarity|tube formation|cell migration|cellular developmental process|microtubule-based process|organelle organization|microtubule organizing center organization|cytosol|centrosome|mitotic cell cycle process|cytoskeleton organization|microtubule organizing center|cell cycle phase transition|centriole|mitotic cell cycle|neuron migration|establishment of cell polarity|nervous system development|cell differentiation|microtubule cytoskeleton organization|cytoskeleton|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|microtubule cytoskeleton|centrosome organization|centriolar satellite|neurogenesis|generation of neurons - - - - 1:243256034-243500092 90 115 174 423 480 413 0.852133008851619 0.989569022052049 1.48535859376432 3.58843139320257 3.72886067745415 3.66476618414767 1.10902020822266 3.6606860849348 -1.72282840933852 4.86434149303212e-11 1.3384336491519e-09 DOWN ENSG00000168522 FNTA farnesyltransferase, CAAX box, alpha [Source:HGNC Symbol;Acc:HGNC:3782] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0051606|GO:0044877|GO:0050794|GO:0043229|GO:0071704|GO:0009628|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0009314|GO:0005102|GO:0097194|GO:0031325|GO:0009582|GO:0051668|GO:0019899|GO:0005737|GO:0071559|GO:0032403|GO:0009966|GO:0010646|GO:0043085|GO:0005875|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0050808|GO:0008092|GO:0008219|GO:0016765|GO:0050790|GO:0010469|GO:0019538|GO:0010033|GO:0031323|GO:0005953|GO:0015631|GO:0043113|GO:0032268|GO:0005829|GO:0007186|GO:0005965|GO:0007166|GO:0043412|GO:0009583|GO:0004659|GO:0051345|GO:0007528|GO:0008277|GO:0008017|GO:0030971|GO:0036211|GO:0071560|GO:0007602|GO:0072657|GO:0022400|GO:1990234|GO:0071478|GO:0051247|GO:0070848|GO:0034613|GO:0019900|GO:0018342|GO:0032270|GO:0012501|GO:0001941|GO:0044267|GO:0071310|GO:0051246|GO:0006921|GO:0005856|GO:0009416|GO:0030548|GO:0043112|GO:0071340|GO:0031401|GO:0008318|GO:0016056|GO:0090045|GO:0071363|GO:0018344|GO:0007179|GO:0043014|GO:0007167|GO:0015630|GO:0009584|GO:0071482|GO:0018343|GO:0007603|GO:0019901|GO:0006464|GO:0045213|GO:0006915|GO:0090312|GO:0004660|GO:0090311|GO:1990782|GO:0007178|GO:0004661|GO:0090044|GO:0004662|GO:0090043|GO:0006476|GO:0004663|GO:0090042 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|detection of stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|response to radiation|receptor binding|execution phase of apoptosis|positive regulation of cellular metabolic process|detection of abiotic stimulus|localization within membrane|enzyme binding|cytoplasm|response to transforming growth factor beta|protein complex binding|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|microtubule associated complex|protein localization|cell communication|membrane organization|signal transduction|synapse organization|cytoskeletal protein binding|cell death|transferase activity, transferring alkyl or aryl (other than methyl) groups|regulation of catalytic activity|regulation of receptor activity|protein metabolic process|response to organic substance|regulation of cellular metabolic process|CAAX-protein geranylgeranyltransferase complex|tubulin binding|receptor clustering|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|protein farnesyltransferase complex|cell surface receptor signaling pathway|macromolecule modification|detection of light stimulus|prenyltransferase activity|positive regulation of hydrolase activity|neuromuscular junction development|regulation of G-protein coupled receptor protein signaling pathway|microtubule binding|receptor tyrosine kinase binding|protein modification process|cellular response to transforming growth factor beta stimulus|phototransduction|protein localization to membrane|regulation of rhodopsin mediated signaling pathway|transferase complex|cellular response to radiation|positive regulation of protein metabolic process|response to growth factor|cellular protein localization|kinase binding|protein prenylation|positive regulation of cellular protein metabolic process|programmed cell death|postsynaptic membrane organization|cellular protein metabolic process|cellular response to organic substance|regulation of protein metabolic process|cellular component disassembly involved in execution phase of apoptosis|cytoskeleton|response to light stimulus|acetylcholine receptor regulator activity|receptor metabolic process|skeletal muscle acetylcholine-gated channel clustering|positive regulation of protein modification process|protein prenyltransferase activity|rhodopsin mediated signaling pathway|positive regulation of deacetylase activity|cellular response to growth factor stimulus|protein geranylgeranylation|transforming growth factor beta receptor signaling pathway|alpha-tubulin binding|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|detection of visible light|cellular response to light stimulus|protein farnesylation|phototransduction, visible light|protein kinase binding|cellular protein modification process|neurotransmitter receptor metabolic process|apoptotic process|positive regulation of protein deacetylation|protein farnesyltransferase activity|regulation of protein deacetylation|protein tyrosine kinase binding|transmembrane receptor protein serine/threonine kinase signaling pathway|protein geranylgeranyltransferase activity|positive regulation of tubulin deacetylation|CAAX-protein geranylgeranyltransferase activity|regulation of tubulin deacetylation|protein deacetylation|Rab geranylgeranyltransferase activity|tubulin deacetylation K05955 protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha[2.5.1.59] hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human) 8:43034194-43085788 164 181 351 735 859 826 0.69884544645122 0.700965789215027 1.34852583673733 2.80622625119448 3.00330166240081 3.29873110382738 0.916112357467859 3.03608633914089 -1.72861636319783 5.11287431694886e-11 1.40552255854688e-09 DOWN ENSG00000082805 ERC1 ELKS/RAB6-interacting/CAST family member 1 [Source:HGNC Symbol;Acc:HGNC:17072] GO:0032502|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048786|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0097060|GO:0031090|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0007275|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0042734|GO:0045184|GO:0019904|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0051090|GO:0016192|GO:0005829|GO:0010468|GO:0034645|GO:0043412|GO:0051252|GO:0030165|GO:0030275|GO:0015031|GO:0010628|GO:0036211|GO:0046907|GO:0051091|GO:1990234|GO:0006796|GO:0035556|GO:0044267|GO:0010467|GO:0000139|GO:0031328|GO:0009059|GO:0051020|GO:0016070|GO:0010557|GO:0045893|GO:0008385|GO:0032774|GO:0042147|GO:2001141|GO:0016310|GO:0051092|GO:0016482|GO:0016197|GO:0007249|GO:0031267|GO:0043522|GO:0006464|GO:0006351|GO:0006355|GO:0017016|GO:1902911|GO:0006468|GO:1903506|GO:0007252|GO:0017137|GO:1902554 developmental process|macromolecular complex|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|presynaptic active zone|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|synaptic membrane|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|presynaptic membrane|establishment of protein localization|protein domain specific binding|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|establishment of localization in cell|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of sequence-specific DNA binding transcription factor activity|vesicle-mediated transport|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|regulation of RNA metabolic process|PDZ domain binding|LRR domain binding|protein transport|positive regulation of gene expression|protein modification process|intracellular transport|positive regulation of sequence-specific DNA binding transcription factor activity|transferase complex|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|Golgi membrane|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|GTPase binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|positive regulation of transcription, DNA-templated|IkappaB kinase complex|RNA biosynthetic process|retrograde transport, endosome to Golgi|regulation of RNA biosynthetic process|phosphorylation|positive regulation of NF-kappaB transcription factor activity|cytosolic transport|endosomal transport|I-kappaB kinase/NF-kappaB signaling|small GTPase binding|leucine zipper domain binding|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|Ras GTPase binding|protein kinase complex|protein phosphorylation|regulation of nucleic acid-templated transcription|I-kappaB phosphorylation|Rab GTPase binding|serine/threonine protein kinase complex - - - - 12:990509-1495933 48 75 218 711 752 641 0.099001153003549 0.140587184528461 0.405390762582075 1.3139223065511 1.27258910153892 1.23905184453428 0.214993033371362 1.27518775087477 -2.56834785971809 5.18659822951106e-11 1.42447749350343e-09 DOWN ENSG00000170214 ADRA1B adrenoceptor alpha 1B [Source:HGNC Symbol;Acc:HGNC:278] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0008283|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0038023|GO:0023051|GO:0043227|GO:0071944|GO:0009893|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0007275|GO:0031325|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0003012|GO:0007267|GO:0005635|GO:0042592|GO:0009966|GO:0046983|GO:1903524|GO:0019725|GO:0010646|GO:0031226|GO:0007154|GO:0007165|GO:0008217|GO:0031965|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0003013|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0007186|GO:0035150|GO:0006936|GO:0043412|GO:0046982|GO:0048878|GO:0090257|GO:0036211|GO:0045907|GO:0055082|GO:0045777|GO:0051247|GO:0045987|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:1902531|GO:0008015|GO:0004930|GO:0005634|GO:0003073|GO:0006941|GO:0008016|GO:0007200|GO:0031401|GO:0007187|GO:0006939|GO:0006937|GO:0043408|GO:0060047|GO:0016310|GO:0019229|GO:0043410|GO:0071875|GO:0050801|GO:0006464|GO:0006873|GO:0033500|GO:0050880|GO:0042593|GO:0007188|GO:0006940|GO:0006468|GO:0006942|GO:0060048|GO:0042325|GO:0001932|GO:0042310|GO:0055117|GO:0071880|GO:0001994|GO:0001934|GO:0001993|GO:0030003|GO:0042327|GO:0007189|GO:0055065|GO:0006875|GO:0006874|GO:0055074|GO:0051480|GO:0007204 developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|cell proliferation|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|signaling receptor activity|regulation of signaling|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|multicellular organism development|positive regulation of cellular metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|muscle system process|cell-cell signaling|nuclear envelope|homeostatic process|regulation of signal transduction|protein dimerization activity|positive regulation of blood circulation|cellular homeostasis|regulation of cell communication|intrinsic component of plasma membrane|cell communication|signal transduction|regulation of blood pressure|nuclear membrane|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|circulatory system process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|regulation of tube size|muscle contraction|macromolecule modification|protein heterodimerization activity|chemical homeostasis|regulation of muscle system process|protein modification process|positive regulation of vasoconstriction|cellular chemical homeostasis|positive regulation of blood pressure|positive regulation of protein metabolic process|positive regulation of smooth muscle contraction|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of intracellular signal transduction|blood circulation|G-protein coupled receptor activity|nucleus|regulation of systemic arterial blood pressure|striated muscle contraction|regulation of heart contraction|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of protein modification process|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|smooth muscle contraction|regulation of muscle contraction|regulation of MAPK cascade|heart contraction|phosphorylation|regulation of vasoconstriction|positive regulation of MAPK cascade|adrenergic receptor signaling pathway|ion homeostasis|cellular protein modification process|cellular ion homeostasis|carbohydrate homeostasis|regulation of blood vessel size|glucose homeostasis|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|regulation of smooth muscle contraction|protein phosphorylation|regulation of striated muscle contraction|cardiac muscle contraction|regulation of phosphorylation|regulation of protein phosphorylation|vasoconstriction|regulation of cardiac muscle contraction|adenylate cyclase-activating adrenergic receptor signaling pathway|norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure|positive regulation of protein phosphorylation|regulation of systemic arterial blood pressure by norepinephrine-epinephrine|cellular cation homeostasis|positive regulation of phosphorylation|adenylate cyclase-activating G-protein coupled receptor signaling pathway|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04136 adrenergic receptor alpha-1B[-] hsa04080|hsa04020|hsa04022|hsa04261|hsa04270|hsa04970 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Salivary secretion - Homo sapiens (human) 5:159916783-159972544 6 11 22 66 99 98 0.244189515356151 0.406899164285175 0.807278708615627 2.40679403660932 3.30596105457236 3.73811809437353 0.486122462752318 3.15029106185174 -2.6960934234757 5.23541663105474e-11 1.43656367742195e-09 DOWN ENSG00000175048 ZDHHC14 zinc finger, DHHC-type containing 14 [Source:HGNC Symbol;Acc:HGNC:20341] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0043231|GO:0043169|GO:0016746|GO:0005737|GO:0005783|GO:0016021|GO:0044249|GO:0019538|GO:0034645|GO:0046872|GO:0043412|GO:0036211|GO:0042157|GO:0016747|GO:0044267|GO:0009059|GO:0016409|GO:0042158|GO:0046914|GO:0006464|GO:0019706|GO:0006497|GO:0008270|GO:0018345 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|cytoplasm|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|protein modification process|lipoprotein metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein metabolic process|macromolecule biosynthetic process|palmitoyltransferase activity|lipoprotein biosynthetic process|transition metal ion binding|cellular protein modification process|protein-cysteine S-palmitoyltransferase activity|protein lipidation|zinc ion binding|protein palmitoylation - - - - 6:157381133-157678146 27 35 45 142 153 143 0.0891521071289643 0.105031321356734 0.133964067465878 0.420098047850922 0.414500201249887 0.442517872089367 0.109382498650525 0.425705373730059 -1.96047337813289 5.40167996028312e-11 1.48082418305135e-09 DOWN ENSG00000230638 RP11-486B10.4 - - - - - - - 1:41542069-41544310 4 4 4 38 38 37 0.126197257713051 0.114696346260606 0.113787782331335 1.07422314043161 0.983707719278528 1.0940475673404 0.118227128768331 1.05065947568351 -3.15166213598075 5.47543683158283e-11 1.49966689146857e-09 DOWN ENSG00000273237 CTB-119C2.1 - - - - - - - 7:26173533-26174945 43 51 33 7 5 5 2.15266019755367 2.3203700146429 1.48948502598349 0.313965965422378 0.205378552883153 0.234606683396314 1.98750507939335 0.251317067233948 2.98337799269004 5.57879829741097e-11 1.52657602539786e-09 UP ENSG00000124664 SPDEF SAM pointed domain containing ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:17257] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0048565|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:1901360|GO:0010941|GO:0007275|GO:0030324|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0010942|GO:0045597|GO:0043231|GO:0000981|GO:0009890|GO:0030323|GO:0006139|GO:0008219|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0060575|GO:0060479|GO:0003677|GO:0010468|GO:0034645|GO:0010453|GO:0055123|GO:0010629|GO:0002064|GO:0051252|GO:0060541|GO:0010628|GO:0010454|GO:0010455|GO:0060433|GO:0012501|GO:0060429|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0043068|GO:0016070|GO:0060428|GO:0010557|GO:0005634|GO:0043067|GO:0045165|GO:0060481|GO:0045893|GO:0043065|GO:0030855|GO:0045892|GO:0060487|GO:0032774|GO:0002066|GO:0043565|GO:0060482|GO:2001141|GO:1902679|GO:0042981|GO:0060576|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0061140|GO:0060480|GO:0000122|GO:0002067 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|digestive tract development|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|tube development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|lung development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell death|positive regulation of cell differentiation|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|respiratory tube development|nucleobase-containing compound metabolic process|cell death|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|intestinal epithelial cell differentiation|lung cell differentiation|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of cell fate commitment|digestive system development|negative regulation of gene expression|epithelial cell development|regulation of RNA metabolic process|respiratory system development|positive regulation of gene expression|negative regulation of cell fate commitment|positive regulation of cell fate commitment|bronchus development|programmed cell death|epithelium development|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|RNA metabolic process|lung epithelium development|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|cell fate commitment|lobar bronchus epithelium development|positive regulation of transcription, DNA-templated|positive regulation of apoptotic process|epithelial cell differentiation|negative regulation of transcription, DNA-templated|lung epithelial cell differentiation|RNA biosynthetic process|columnar/cuboidal epithelial cell development|sequence-specific DNA binding|lobar bronchus development|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of apoptotic process|intestinal epithelial cell development|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|lung secretory cell differentiation|lung goblet cell differentiation|negative regulation of transcription from RNA polymerase II promoter|glandular epithelial cell differentiation - - - - 6:34537802-34556333 56 54 62 196 222 294 1.72229491649736 1.50935404881294 1.71917640308207 5.40095577541534 5.60193777140376 8.47412053361443 1.65027512279746 6.49233802681118 -1.97603155551612 5.59807457606322e-11 1.53044797063911e-09 DOWN ENSG00000153093 ACOXL acyl-CoA oxidase-like [Source:HGNC Symbol;Acc:HGNC:25621] GO:0009055|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0005622|GO:0044255|GO:0006082|GO:0043168|GO:0044281|GO:0043231|GO:0005737|GO:0042592|GO:0006629|GO:0016627|GO:0050662|GO:0000166|GO:0000062|GO:0055114|GO:0016042|GO:0050660|GO:0048878|GO:0044242|GO:0006631|GO:0052890|GO:0034440|GO:0003995|GO:0030258|GO:0005777|GO:0046395|GO:0003997|GO:0019752|GO:0055088|GO:0009062|GO:0019395|GO:0006635|GO:0032787|GO:0033539 electron carrier activity|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|intracellular|cellular lipid metabolic process|organic acid metabolic process|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|lipid metabolic process|oxidoreductase activity, acting on the CH-CH group of donors|coenzyme binding|nucleotide binding|fatty-acyl-CoA binding|oxidation-reduction process|lipid catabolic process|flavin adenine dinucleotide binding|chemical homeostasis|cellular lipid catabolic process|fatty acid metabolic process|oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor|lipid oxidation|acyl-CoA dehydrogenase activity|lipid modification|peroxisome|carboxylic acid catabolic process|acyl-CoA oxidase activity|carboxylic acid metabolic process|lipid homeostasis|fatty acid catabolic process|fatty acid oxidation|fatty acid beta-oxidation|monocarboxylic acid metabolic process|fatty acid beta-oxidation using acyl-CoA dehydrogenase - - - - 2:110732573-111118222 34 30 56 165 199 157 0.339939740231153 0.272596333904182 0.504806242185473 1.47809018091328 1.63245001459758 1.47112393534408 0.372447438773603 1.52722137695165 -2.03580045547286 5.6405614253349e-11 1.54065252325662e-09 DOWN ENSG00000178038 ALS2CL ALS2 C-terminal like [Source:HGNC Symbol;Acc:HGNC:20605] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0016043|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0005085|GO:0019222|GO:0042802|GO:0008047|GO:0005737|GO:0005088|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0010256|GO:0006996|GO:0005096|GO:0051345|GO:0030695|GO:0035556|GO:0005089|GO:1902531|GO:0007032|GO:0043087|GO:0043547|GO:0051056|GO:0007264|GO:0007265|GO:0046578|GO:0035023|GO:0007266 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|cellular component organization|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|identical protein binding|enzyme activator activity|cytoplasm|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|endomembrane system organization|organelle organization|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|Rho guanyl-nucleotide exchange factor activity|regulation of intracellular signal transduction|endosome organization|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of Rho protein signal transduction|Rho protein signal transduction - - - - 3:46668997-46693704 44 53 129 340 364 456 0.172738888423635 0.189102976737071 0.456606454009211 1.19595874048126 1.17248805577321 1.6777726604929 0.272816106389972 1.34873981891579 -2.30561134429513 5.66386031489174e-11 1.54560224717347e-09 DOWN ENSG00000136828 RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 [Source:HGNC Symbol;Acc:HGNC:16851] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0023051|GO:0071944|GO:0009893|GO:0005622|GO:0005886|GO:0005085|GO:0019222|GO:0005737|GO:0005088|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0051345|GO:0008321|GO:0035556|GO:1902531|GO:0043087|GO:0043547|GO:0051056|GO:0007264|GO:0007265|GO:0046578|GO:0032485 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of signaling|cell periphery|positive regulation of metabolic process|intracellular|plasma membrane|guanyl-nucleotide exchange factor activity|regulation of metabolic process|cytoplasm|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|positive regulation of hydrolase activity|Ral guanyl-nucleotide exchange factor activity|intracellular signal transduction|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of Ral protein signal transduction - - - - 9:126914774-127223166 24 39 129 449 464 1023 0.0951129907392492 0.140469225488351 0.46092974891243 1.59432310529409 1.50875193732718 3.79958821492544 0.232170655046677 2.30088775251557 -3.30893306323775 5.79654175614112e-11 1.58036490947796e-09 DOWN ENSG00000230257 NFE4 nuclear factor, erythroid 4 [Source:HGNC Symbol;Acc:HGNC:29902] - - - - - - 7:102973522-102988856 189 213 237 631 628 602 12.4713366382628 12.7735314995333 14.0998425441003 37.3059136691733 33.9999589901235 37.2285684763664 13.1149035606321 36.1781470452211 -1.46391131969463 5.81321735537561e-11 1.5834652456878e-09 DOWN ENSG00000234741 GAS5 growth arrest specific 5 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:16355] - - - - - - 1:173863900-173868882 5756 5617 5369 2313 2044 2662 34.7555560359388 30.8239207979515 29.2288049735494 12.5134394296351 10.1263365150667 15.064003111832 31.6027606024799 12.5679263521779 1.33030395634258 5.85265493547988e-11 1.59275442519431e-09 UP ENSG00000159023 EPB41 erythrocyte membrane protein band 4.1 [Source:HGNC Symbol;Acc:HGNC:3377] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0005200|GO:0019898|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0005938|GO:0043168|GO:0005543|GO:0051098|GO:0043231|GO:0005737|GO:0005516|GO:0008092|GO:0030029|GO:0003013|GO:0006996|GO:0030864|GO:0007010|GO:0035091|GO:0003779|GO:0051099|GO:0030036|GO:0008091|GO:0008015|GO:0005856|GO:0005634|GO:0030507|GO:0043393|GO:0015629|GO:0014731|GO:0030866|GO:0005545|GO:0030865|GO:0032092|GO:0030863 macromolecular complex|structural molecule activity|cell|membrane|cellular process|cell junction|binding|structural constituent of cytoskeleton|extrinsic component of membrane|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|intracellular|protein binding|plasma membrane|protein complex|cell cortex|anion binding|phospholipid binding|regulation of binding|intracellular membrane-bounded organelle|cytoplasm|calmodulin binding|cytoskeletal protein binding|actin filament-based process|circulatory system process|organelle organization|cortical actin cytoskeleton|cytoskeleton organization|phosphatidylinositol binding|actin binding|positive regulation of binding|actin cytoskeleton organization|spectrin|blood circulation|cytoskeleton|nucleus|spectrin binding|regulation of protein binding|actin cytoskeleton|spectrin-associated cytoskeleton|cortical actin cytoskeleton organization|1-phosphatidylinositol binding|cortical cytoskeleton organization|positive regulation of protein binding|cortical cytoskeleton K06107 erythrocyte membrane protein band 4.1[-] hsa04530 Tight junction - Homo sapiens (human) 1:28887091-29120046 226 236 416 828 941 997 1.17151649543626 1.11181322663494 1.94423289953799 3.84563613135878 4.00219111015746 4.84355922014747 1.4091875405364 4.2304621538879 -1.58595165388973 5.86720539714105e-11 1.59526001754325e-09 DOWN ENSG00000187240 DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 [Source:HGNC Symbol;Acc:HGNC:2962] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0019882|GO:0043229|GO:0071704|GO:0043167|GO:0051641|GO:0045177|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0005929|GO:0048646|GO:0007507|GO:0019884|GO:0006810|GO:0001568|GO:0005930|GO:0007275|GO:0048513|GO:0043168|GO:0005874|GO:0030900|GO:0021517|GO:0001882|GO:0031982|GO:0016817|GO:0007420|GO:0022607|GO:0043231|GO:0005737|GO:0007389|GO:0060322|GO:0006928|GO:0009966|GO:0048598|GO:0045184|GO:0072372|GO:0010646|GO:0005875|GO:0008104|GO:0007154|GO:0010970|GO:0007165|GO:0070062|GO:0051649|GO:0097542|GO:0002504|GO:0048002|GO:0000166|GO:0030030|GO:0048869|GO:0009967|GO:0007017|GO:0019538|GO:0010256|GO:0005794|GO:0006996|GO:0000902|GO:0005829|GO:0008105|GO:0007166|GO:0035639|GO:0001944|GO:0007030|GO:0072358|GO:0007417|GO:0060976|GO:0021510|GO:0001883|GO:0051604|GO:0045880|GO:0015031|GO:0008589|GO:0031512|GO:0009790|GO:0016818|GO:0044782|GO:0046907|GO:0032549|GO:0003002|GO:0030031|GO:0007018|GO:0030286|GO:0006508|GO:0034613|GO:0070925|GO:0042384|GO:0035108|GO:0010467|GO:0032990|GO:0031503|GO:0007399|GO:0017076|GO:0030154|GO:0048858|GO:0060173|GO:0072359|GO:0021522|GO:0005856|GO:0002495|GO:0030182|GO:0060271|GO:0021953|GO:0042073|GO:0016485|GO:0005524|GO:0007224|GO:0030554|GO:0021515|GO:0006886|GO:0019886|GO:0015630|GO:0009855|GO:0009953|GO:0022008|GO:0030705|GO:0030326|GO:0016462|GO:0048699|GO:0007368|GO:0017111|GO:0035721|GO:0016887|GO:0003774|GO:0003777 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|antigen processing and presentation|intracellular organelle|organic substance metabolic process|ion binding|cellular localization|apical part of cell|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|plasma membrane|protein complex|endomembrane system|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|heart development|antigen processing and presentation of exogenous antigen|transport|blood vessel development|axoneme|multicellular organism development|animal organ development|anion binding|microtubule|forebrain development|ventral spinal cord development|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|brain development|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|head development|movement of cell or subcellular component|regulation of signal transduction|embryonic morphogenesis|establishment of protein localization|primary cilium|regulation of cell communication|microtubule associated complex|protein localization|cell communication|establishment of localization by movement along microtubule|signal transduction|extracellular exosome|establishment of localization in cell|ciliary tip|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|antigen processing and presentation of peptide antigen|nucleotide binding|cell projection organization|cellular developmental process|positive regulation of signal transduction|microtubule-based process|protein metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|cell morphogenesis|cytosol|asymmetric protein localization|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|vasculature development|Golgi organization|cardiovascular system development|central nervous system development|coronary vasculature development|spinal cord development|purine nucleoside binding|protein maturation|positive regulation of smoothened signaling pathway|protein transport|regulation of smoothened signaling pathway|motile primary cilium|embryo development|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cilium organization|intracellular transport|ribonucleoside binding|regionalization|cell projection assembly|microtubule-based movement|dynein complex|proteolysis|cellular protein localization|organelle assembly|cilium assembly|limb morphogenesis|gene expression|cell part morphogenesis|protein complex localization|nervous system development|purine nucleotide binding|cell differentiation|cell projection morphogenesis|limb development|circulatory system development|spinal cord motor neuron differentiation|cytoskeleton|antigen processing and presentation of peptide antigen via MHC class II|neuron differentiation|cilium morphogenesis|central nervous system neuron differentiation|intraciliary transport|protein processing|ATP binding|smoothened signaling pathway|adenyl nucleotide binding|cell differentiation in spinal cord|intracellular protein transport|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule cytoskeleton|determination of bilateral symmetry|dorsal/ventral pattern formation|neurogenesis|cytoskeleton-dependent intracellular transport|embryonic limb morphogenesis|pyrophosphatase activity|generation of neurons|determination of left/right symmetry|nucleoside-triphosphatase activity|intraciliary retrograde transport|ATPase activity|motor activity|microtubule motor activity K10414 dynein heavy chain 2, cytosolic[-] hsa04145|hsa05132|hsa04962 Phagosome - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Vasopressin-regulated water reabsorption - Homo sapiens (human) 11:103109431-103479863 39 55 146 419 425 573 0.155001030812551 0.198664571244336 0.52316713103187 1.49206156008547 1.38589928736347 2.13431437467467 0.292277577696252 1.67075840737454 -2.5150920729294 5.92171759700075e-11 1.60861653449372e-09 DOWN ENSG00000166012 TAF1D TATA-box binding protein associated factor, RNA polymerase I, D [Source:HGNC Symbol;Acc:HGNC:28759] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005667|GO:0009890|GO:0016458|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0044798|GO:0010629|GO:0051252|GO:0006325|GO:0005815|GO:0031981|GO:0005654|GO:0006342|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0045814|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0040029|GO:0015630|GO:0000183|GO:0006351|GO:0006355|GO:0000120|GO:1903507|GO:0006352|GO:0006360|GO:1903506|GO:0006354|GO:0005668|GO:0006353|GO:0006361|GO:0006362|GO:0006363 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor complex|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|nuclear transcription factor complex|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|microtubule organizing center|nuclear lumen|nucleoplasm|chromatin silencing|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|microtubule cytoskeleton|chromatin silencing at rDNA|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA polymerase I transcription factor complex|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|transcription from RNA polymerase I promoter|regulation of nucleic acid-templated transcription|DNA-templated transcription, elongation|RNA polymerase transcription factor SL1 complex|DNA-templated transcription, termination|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription - - - - 11:93729948-93784391 2294 2260 2392 1064 1142 999 7.79246768878529 6.97702099724569 7.32583376024146 3.23832995756101 3.18284720503531 3.18035826973145 7.36510748209081 3.20051181077592 1.20240394670818 6.01222242965843e-11 1.6317171674093e-09 UP ENSG00000204524 ZNF805 zinc finger protein 805 [Source:HGNC Symbol;Acc:HGNC:23272] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 19:57240685-57255135 327 331 310 82 66 125 5.52843412755898 5.08583351167062 4.72530165682392 1.24212178755361 0.915522376385547 1.98058697979703 5.11318976535117 1.3794103812454 1.8901718401821 6.03582919597241e-11 1.63663619270264e-09 UP ENSG00000011295 TTC19 tetratricopeptide repeat domain 19 [Source:HGNC Symbol;Acc:HGNC:26006] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0030496|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0031090|GO:0007049|GO:0019866|GO:0022402|GO:0022607|GO:0043231|GO:0005737|GO:0031966|GO:0051301|GO:0006996|GO:0005740|GO:0005813|GO:0007005|GO:0005815|GO:0097033|GO:0005743|GO:0005739|GO:0006461|GO:0005856|GO:0000910|GO:0034622|GO:0034551|GO:0043623|GO:0015630|GO:0033108|GO:0017004 cell|membrane|cellular process|binding|midbody|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|organelle membrane|cell cycle|organelle inner membrane|cell cycle process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|cell division|organelle organization|mitochondrial envelope|centrosome|mitochondrion organization|microtubule organizing center|mitochondrial respiratory chain complex III biogenesis|mitochondrial inner membrane|mitochondrion|protein complex assembly|cytoskeleton|cytokinesis|cellular macromolecular complex assembly|mitochondrial respiratory chain complex III assembly|cellular protein complex assembly|microtubule cytoskeleton|mitochondrial respiratory chain complex assembly|cytochrome complex assembly - - - - 17:15999380-16045015 159 166 198 561 618 456 0.914698557732188 0.867899491308192 1.02697792400623 2.89162915789781 2.91701483151542 2.45853186375741 0.93652532434887 2.75572528439021 -1.55704216265892 6.49500650773545e-11 1.75954559239505e-09 DOWN ENSG00000117528 ABCD3 ATP binding cassette subfamily D member 3 [Source:HGNC Symbol;Acc:HGNC:67] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0031090|GO:0042802|GO:0044255|GO:0019866|GO:0006810|GO:0006082|GO:0043168|GO:0044281|GO:0001882|GO:0016817|GO:0043231|GO:0005737|GO:0046983|GO:0031966|GO:0005319|GO:0042493|GO:0055085|GO:0006629|GO:0043621|GO:0000166|GO:0016021|GO:0044249|GO:0010876|GO:0010033|GO:0006996|GO:0055114|GO:0005740|GO:0016820|GO:0005829|GO:0035639|GO:0016042|GO:0044242|GO:0006631|GO:0001883|GO:0015245|GO:0016818|GO:0034440|GO:0006811|GO:0032549|GO:0005743|GO:0006869|GO:0007031|GO:0005739|GO:0014070|GO:0008610|GO:0017076|GO:0030258|GO:0042803|GO:0005778|GO:0006820|GO:0015711|GO:0005777|GO:0005524|GO:0046395|GO:0030554|GO:0005782|GO:0015908|GO:0046942|GO:0000038|GO:0006633|GO:0019752|GO:0005324|GO:0042626|GO:0009062|GO:0019395|GO:0016462|GO:0015718|GO:0006635|GO:0042760|GO:0017111|GO:0032787|GO:0015909|GO:0016887|GO:0015910|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|organelle membrane|identical protein binding|cellular lipid metabolic process|organelle inner membrane|transport|organic acid metabolic process|anion binding|small molecule metabolic process|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|mitochondrial membrane|lipid transporter activity|response to drug|transmembrane transport|lipid metabolic process|protein self-association|nucleotide binding|integral component of membrane|cellular biosynthetic process|lipid localization|response to organic substance|organelle organization|oxidation-reduction process|mitochondrial envelope|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|cytosol|purine ribonucleoside triphosphate binding|lipid catabolic process|cellular lipid catabolic process|fatty acid metabolic process|purine nucleoside binding|fatty acid transporter activity|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|lipid oxidation|ion transport|ribonucleoside binding|mitochondrial inner membrane|lipid transport|peroxisome organization|mitochondrion|response to organic cyclic compound|lipid biosynthetic process|purine nucleotide binding|lipid modification|protein homodimerization activity|peroxisomal membrane|anion transport|organic anion transport|peroxisome|ATP binding|carboxylic acid catabolic process|adenyl nucleotide binding|peroxisomal matrix|fatty acid transport|carboxylic acid transport|very long-chain fatty acid metabolic process|fatty acid biosynthetic process|carboxylic acid metabolic process|long-chain fatty acid transporter activity|ATPase activity, coupled to transmembrane movement of substances|fatty acid catabolic process|fatty acid oxidation|pyrophosphatase activity|monocarboxylic acid transport|fatty acid beta-oxidation|very long-chain fatty acid catabolic process|nucleoside-triphosphatase activity|monocarboxylic acid metabolic process|long-chain fatty acid transport|ATPase activity|peroxisomal long-chain fatty acid import|ATPase activity, coupled|ATPase activity, coupled to movement of substances K05677 ATP-binding cassette, subfamily D (ALD), member 3[-] hsa04146|hsa02010 Peroxisome - Homo sapiens (human)|ABC transporters - Homo sapiens (human) 1:94418455-94518666 404 487 730 1574 1639 1476 2.58926199601673 2.83663554744629 4.21824558188218 9.03851842494622 8.61869513609295 8.8656365037675 3.21471437511507 8.84095002160222 -1.45951084465907 6.62752195610955e-11 1.79381723007883e-09 DOWN ENSG00000163682 RPL9 ribosomal protein L9 [Source:HGNC Symbol;Acc:HGNC:10369] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0097159|GO:0030055|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016032|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0005924|GO:0005912|GO:0046483|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0045184|GO:0006139|GO:0008104|GO:0061024|GO:0051649|GO:0044249|GO:0019538|GO:0005730|GO:0005829|GO:0034645|GO:0090150|GO:0006518|GO:0003723|GO:0072594|GO:0045047|GO:0005840|GO:0015031|GO:0044265|GO:0046907|GO:0019083|GO:0072657|GO:0031981|GO:0015934|GO:0034613|GO:0043603|GO:0044267|GO:0010467|GO:0019058|GO:0019439|GO:0009059|GO:0016070|GO:0005634|GO:0005925|GO:0006401|GO:0043241|GO:0043043|GO:0006614|GO:0033365|GO:0032774|GO:0019843|GO:0022626|GO:0006605|GO:0006412|GO:0006886|GO:0016071|GO:0022625|GO:0006612|GO:0072599|GO:0006414|GO:0070972|GO:0006613|GO:0043624|GO:0006402|GO:0006415|GO:0002181|GO:0000956|GO:0000184 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|cell junction|binding|organic cyclic compound binding|cell-substrate junction|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|viral process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|cell-substrate adherens junction|adherens junction|heterocycle metabolic process|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|membrane organization|establishment of localization in cell|cellular biosynthetic process|protein metabolic process|nucleolus|cytosol|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|peptide metabolic process|RNA binding|establishment of protein localization to organelle|protein targeting to ER|ribosome|protein transport|cellular macromolecule catabolic process|intracellular transport|viral transcription|protein localization to membrane|nuclear lumen|large ribosomal subunit|cellular protein localization|cellular amide metabolic process|cellular protein metabolic process|gene expression|viral life cycle|aromatic compound catabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|focal adhesion|RNA catabolic process|protein complex disassembly|peptide biosynthetic process|SRP-dependent cotranslational protein targeting to membrane|protein localization to organelle|RNA biosynthetic process|rRNA binding|cytosolic ribosome|protein targeting|translation|intracellular protein transport|mRNA metabolic process|cytosolic large ribosomal subunit|protein targeting to membrane|establishment of protein localization to endoplasmic reticulum|translational elongation|protein localization to endoplasmic reticulum|cotranslational protein targeting to membrane|cellular protein complex disassembly|mRNA catabolic process|translational termination|cytoplasmic translation|nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay K02940 large subunit ribosomal protein L9e[-] hsa03010 Ribosome - Homo sapiens (human) 4:39454124-39458948 1039 1250 965 457 530 402 12.4716756052964 13.6363905137397 10.4436198185162 4.91499334957352 5.21978632798253 4.52234582201113 12.1838953125174 4.88570849985573 1.31833575639101 6.6885961739351e-11 1.80870788203495e-09 UP ENSG00000259264 RP11-60L3.1 - - - - - - - 15:74202705-74221557 5 4 8 42 44 75 0.129893846939138 0.0944359927713103 0.187375841341795 0.977573151404705 0.937817740757171 1.8259513602947 0.137235227017414 1.24711408415219 -3.18387068613731 6.701228985843e-11 1.81048407369554e-09 DOWN ENSG00000167656 LY6D lymphocyte antigen 6 complex, locus D [Source:HGNC Symbol;Acc:HGNC:13348] GO:0032502|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0045321|GO:0009986|GO:0007155|GO:0071944|GO:0031224|GO:0002520|GO:0005886|GO:0048856|GO:0031225|GO:0007275|GO:0048513|GO:0001775|GO:0046649|GO:0048869|GO:0010033|GO:0030097|GO:0030098|GO:0014070|GO:0030154|GO:0002521|GO:0080184|GO:0035634 developmental process|immune system process|cell|membrane|cellular process|response to stimulus|leukocyte activation|cell surface|cell adhesion|cell periphery|intrinsic component of membrane|immune system development|plasma membrane|anatomical structure development|anchored component of membrane|multicellular organism development|animal organ development|cell activation|lymphocyte activation|cellular developmental process|response to organic substance|hemopoiesis|lymphocyte differentiation|response to organic cyclic compound|cell differentiation|leukocyte differentiation|response to phenylpropanoid|response to stilbenoid - - - - 8:142784880-142786592 298 298 434 901 955 1095 5.94461242887384 5.40259899028841 7.80567973341301 16.1038332186381 15.6306927093334 20.4715137759174 6.38429705085842 17.4020132346296 -1.44665453629783 6.74844799174579e-11 1.82159282410107e-09 DOWN ENSG00000168818 STX18 syntaxin 18 [Source:HGNC Symbol;Acc:HGNC:15942] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0051050|GO:0044089|GO:0042175|GO:0051641|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0060341|GO:0031201|GO:1902117|GO:1902115|GO:0006810|GO:0051130|GO:0060627|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0005484|GO:0045184|GO:0019904|GO:0032388|GO:0008104|GO:0061024|GO:0005783|GO:0051649|GO:0016021|GO:0010256|GO:0005794|GO:0006996|GO:0061025|GO:0016192|GO:0090158|GO:0007030|GO:0032386|GO:0015031|GO:0046907|GO:0034613|GO:0070925|GO:0033043|GO:0007029|GO:0000139|GO:0060628|GO:0010638|GO:1902953|GO:0048193|GO:1903358|GO:0016482|GO:0006886|GO:0006890|GO:0006888 macromolecular complex|cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|positive regulation of transport|positive regulation of cellular component biogenesis|nuclear outer membrane-endoplasmic reticulum membrane network|cellular localization|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|regulation of cellular localization|SNARE complex|positive regulation of organelle assembly|regulation of organelle assembly|transport|positive regulation of cellular component organization|regulation of vesicle-mediated transport|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|SNAP receptor activity|establishment of protein localization|protein domain specific binding|positive regulation of intracellular transport|protein localization|membrane organization|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|endomembrane system organization|Golgi apparatus|organelle organization|membrane fusion|vesicle-mediated transport|endoplasmic reticulum membrane organization|Golgi organization|regulation of intracellular transport|protein transport|intracellular transport|cellular protein localization|organelle assembly|regulation of organelle organization|endoplasmic reticulum organization|Golgi membrane|regulation of ER to Golgi vesicle-mediated transport|positive regulation of organelle organization|positive regulation of ER to Golgi vesicle-mediated transport|Golgi vesicle transport|regulation of Golgi organization|cytosolic transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER|ER to Golgi vesicle-mediated transport K08492 syntaxin 18[-] hsa04145|hsa04130 Phagosome - Homo sapiens (human)|SNARE interactions in vesicular transport - Homo sapiens (human) 4:4415742-4542346 99 112 122 441 397 314 0.706937301245546 0.726850174929919 0.785455491473636 2.8215249632081 2.32598047651124 2.10138634851286 0.739747655883034 2.41629726274407 -1.70769282689128 6.77787156813825e-11 1.82788236490695e-09 DOWN ENSG00000011566 MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0006950|GO:0005057|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0023051|GO:0009893|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0051726|GO:0007049|GO:0009314|GO:0010941|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0033554|GO:0005737|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0004702|GO:0008219|GO:0050790|GO:0000166|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0035639|GO:0043412|GO:0034097|GO:0008349|GO:0001883|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0031098|GO:0007346|GO:0051247|GO:0016301|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:1902531|GO:0016773|GO:0009416|GO:0043067|GO:0031401|GO:0009411|GO:0043408|GO:0005524|GO:0030554|GO:0016310|GO:0043410|GO:0042981|GO:0004672|GO:0034612|GO:0006464|GO:0051403|GO:0043549|GO:0006915|GO:0033674|GO:0045859|GO:0045860|GO:0006468|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0004674|GO:0000185|GO:0001934|GO:0042327|GO:0071902|GO:0071900|GO:0032147 signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|response to stress|receptor signaling protein activity|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|positive regulation of metabolic process|intracellular|protein binding|transferase activity|regulation of metabolic process|regulation of cell cycle|cell cycle|response to radiation|regulation of cell death|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|cellular response to stress|cytoplasm|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|receptor signaling protein serine/threonine kinase activity|cell death|regulation of catalytic activity|nucleotide binding|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|response to cytokine|MAP kinase kinase kinase kinase activity|purine nucleoside binding|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|positive regulation of protein metabolic process|kinase activity|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|response to light stimulus|regulation of programmed cell death|positive regulation of protein modification process|response to UV|regulation of MAPK cascade|ATP binding|adenyl nucleotide binding|phosphorylation|positive regulation of MAPK cascade|regulation of apoptotic process|protein kinase activity|response to tumor necrosis factor|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity|activation of MAPKKK activity|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity K04406 mitogen-activated protein kinase kinase kinase kinase 3[2.7.11.1] hsa04010 MAPK signaling pathway - Homo sapiens (human) 2:39249266-39437312 314 373 618 1193 1419 1320 2.0177506305329 2.17834248729567 3.58047192120847 6.86871588758884 7.48148162033512 7.94950804066593 2.59218834634568 7.4332351828633 -1.51981970759133 6.90998454354777e-11 1.86182922890862e-09 DOWN ENSG00000119900 OGFRL1 opioid growth factor receptor-like 1 [Source:HGNC Symbol;Acc:HGNC:21378] GO:0016020|GO:0004872 membrane|receptor activity - - - - 6:71288803-71308950 649 900 785 322 376 300 5.0282843191893 6.33719964079718 5.48351251090057 2.23526059573585 2.39018158961548 2.17833424968012 5.61633215696235 2.26792547834382 1.30825502535789 7.04922879331978e-11 1.89763459328917e-09 UP ENSG00000138777 PPA2 pyrophosphatase (inorganic) 2 [Source:HGNC Symbol;Acc:HGNC:28883] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0016788|GO:0044281|GO:0031982|GO:0046483|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0006520|GO:0006139|GO:0070062|GO:0044249|GO:0019538|GO:0034645|GO:0071344|GO:0006518|GO:0046872|GO:0043412|GO:0016818|GO:0036211|GO:0005759|GO:0005739|GO:0006796|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0042578|GO:0016311|GO:0043043|GO:0043039|GO:0000287|GO:0034660|GO:0006412|GO:0016791|GO:0019752|GO:0006464|GO:0016462|GO:0006470|GO:0006418|GO:0004721|GO:0006399|GO:0004427|GO:0004722 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|extracellular exosome|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|diphosphate metabolic process|peptide metabolic process|metal ion binding|macromolecule modification|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|mitochondrial matrix|mitochondrion|phosphate-containing compound metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|phosphoric ester hydrolase activity|dephosphorylation|peptide biosynthetic process|tRNA aminoacylation|magnesium ion binding|ncRNA metabolic process|translation|phosphatase activity|carboxylic acid metabolic process|cellular protein modification process|pyrophosphatase activity|protein dephosphorylation|tRNA aminoacylation for protein translation|phosphoprotein phosphatase activity|tRNA metabolic process|inorganic diphosphatase activity|protein serine/threonine phosphatase activity K01507 inorganic pyrophosphatase[3.6.1.1] hsa00190 Oxidative phosphorylation - Homo sapiens (human) 4:105369077-105474081 401 463 509 1334 1353 1056 3.51666883594318 3.69018736514593 4.02457154871131 10.4819286109828 9.7353907978181 8.67921667650267 3.74380924993347 9.63217869510119 -1.36335522673168 7.06653542434495e-11 1.90057971674229e-09 DOWN ENSG00000171853 TRAPPC12 trafficking protein particle complex 12 [Source:HGNC Symbol;Acc:HGNC:24284] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0006810|GO:0043231|GO:0008233|GO:0005737|GO:0019538|GO:0016192|GO:0005793|GO:0006508|GO:0004175 cell|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|transport|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|protein metabolic process|vesicle-mediated transport|endoplasmic reticulum-Golgi intermediate compartment|proteolysis|endopeptidase activity - - - - 2:3379675-3485094 148 145 186 449 533 494 0.751815521936856 0.669421129344556 0.851876763347937 2.04359591428324 2.2214960425282 2.35183110866183 0.757704471543116 2.20564102182442 -1.54149083781248 7.07832345825762e-11 1.90203662036744e-09 DOWN ENSG00000111186 WNT5B wingless-type MMTV integration site family member 5B [Source:HGNC Symbol;Acc:HGNC:16265] GO:0040011|GO:0032502|GO:0031012|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0005578|GO:0006950|GO:0009986|GO:0048870|GO:0023051|GO:0040017|GO:0043227|GO:0071944|GO:0023057|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0051272|GO:0045595|GO:0009888|GO:0048468|GO:0002088|GO:0007275|GO:0048513|GO:0005102|GO:0031982|GO:2000147|GO:0045597|GO:0043231|GO:0005737|GO:0009611|GO:0007423|GO:0012506|GO:0006928|GO:0030666|GO:0009966|GO:0010646|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0009968|GO:0070062|GO:0048869|GO:2000145|GO:0010033|GO:0005794|GO:0030111|GO:0030178|GO:0051216|GO:0007166|GO:0001654|GO:0033993|GO:0031410|GO:0002064|GO:0030334|GO:0016023|GO:0042060|GO:0005796|GO:0045600|GO:0031988|GO:0001664|GO:0070306|GO:0060429|GO:0032526|GO:0030659|GO:0005788|GO:0007399|GO:0071310|GO:0045598|GO:0030154|GO:0001501|GO:0061448|GO:0030335|GO:0045165|GO:0030182|GO:0016055|GO:0045444|GO:0090090|GO:0070307|GO:0030139|GO:0030855|GO:0060828|GO:0043010|GO:0002062|GO:0005109|GO:0071300|GO:0022008|GO:0071396|GO:0048699|GO:0060070 locomotion|developmental process|extracellular matrix|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|proteinaceous extracellular matrix|response to stress|cell surface|cell motility|regulation of signaling|positive regulation of locomotion|membrane-bounded organelle|cell periphery|negative regulation of signaling|extracellular space|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|positive regulation of cellular component movement|regulation of cell differentiation|tissue development|cell development|lens development in camera-type eye|multicellular organism development|animal organ development|receptor binding|vesicle|positive regulation of cell motility|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|response to wounding|sensory organ development|vesicle membrane|movement of cell or subcellular component|endocytic vesicle membrane|regulation of signal transduction|regulation of cell communication|cell communication|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|extracellular exosome|cellular developmental process|regulation of cell motility|response to organic substance|Golgi apparatus|regulation of Wnt signaling pathway|negative regulation of Wnt signaling pathway|cartilage development|cell surface receptor signaling pathway|eye development|response to lipid|cytoplasmic vesicle|epithelial cell development|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|wound healing|Golgi lumen|positive regulation of fat cell differentiation|membrane-bounded vesicle|G-protein coupled receptor binding|lens fiber cell differentiation|epithelium development|response to retinoic acid|cytoplasmic vesicle membrane|endoplasmic reticulum lumen|nervous system development|cellular response to organic substance|regulation of fat cell differentiation|cell differentiation|skeletal system development|connective tissue development|positive regulation of cell migration|cell fate commitment|neuron differentiation|Wnt signaling pathway|fat cell differentiation|negative regulation of canonical Wnt signaling pathway|lens fiber cell development|endocytic vesicle|epithelial cell differentiation|regulation of canonical Wnt signaling pathway|camera-type eye development|chondrocyte differentiation|frizzled binding|cellular response to retinoic acid|neurogenesis|cellular response to lipid|generation of neurons|canonical Wnt signaling pathway K00444 wingless-type MMTV integration site family, member 5[-] hsa05200|hsa05166|hsa05205|hsa04360|hsa04390|hsa04310|hsa04550|hsa04916|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 12:1529891-1647243 174 152 120 43 38 30 1.54509619652533 1.22667209590994 0.96072884691745 0.342114045289458 0.276860746500434 0.249667892082996 1.24416571311757 0.289547561290963 2.10330640301496 7.11267736771241e-11 1.90954919186768e-09 UP ENSG00000078304 PPP2R5C protein phosphatase 2 regulatory subunit B', gamma [Source:HGNC Symbol;Acc:HGNC:9311] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0031224|GO:0008287|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0051726|GO:0042127|GO:0007049|GO:0022402|GO:0019208|GO:0033554|GO:0045786|GO:0043231|GO:0008233|GO:0045787|GO:0000159|GO:0007154|GO:0007165|GO:0008219|GO:0008285|GO:0050790|GO:0016021|GO:0019538|GO:0031323|GO:0032268|GO:0000075|GO:0090068|GO:1903047|GO:0043412|GO:0030163|GO:0044770|GO:0051604|GO:0044265|GO:0007050|GO:0036211|GO:0000278|GO:0007346|GO:0010564|GO:0045930|GO:0006508|GO:0005694|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0019888|GO:0051246|GO:0072395|GO:0005634|GO:0006974|GO:0097190|GO:0010948|GO:0044257|GO:0097193|GO:0016311|GO:0071156|GO:0010498|GO:0016485|GO:0007093|GO:0072331|GO:0042770|GO:0008601|GO:0044772|GO:0044774|GO:0000077|GO:1901990|GO:0051603|GO:0008630|GO:1901987|GO:0006464|GO:0006915|GO:0044773|GO:1901991|GO:0010921|GO:0071158|GO:0000775|GO:0006470|GO:0035304|GO:2000045|GO:0072332|GO:0044819|GO:0019941|GO:0042771|GO:0043666|GO:0044783|GO:1902806|GO:2000134|GO:0000082|GO:0031571|GO:1902807|GO:0006977|GO:0035303|GO:0030330|GO:0043161|GO:0072422|GO:0072431|GO:0006511|GO:0034047 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|protein serine/threonine phosphatase complex|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|cell cycle process|phosphatase regulator activity|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|peptidase activity|positive regulation of cell cycle|protein phosphatase type 2A complex|cell communication|signal transduction|cell death|negative regulation of cell proliferation|regulation of catalytic activity|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cell cycle checkpoint|positive regulation of cell cycle process|mitotic cell cycle process|macromolecule modification|protein catabolic process|cell cycle phase transition|protein maturation|cellular macromolecule catabolic process|cell cycle arrest|protein modification process|mitotic cell cycle|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|proteolysis|chromosome|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|protein phosphatase regulator activity|regulation of protein metabolic process|signal transduction involved in cell cycle checkpoint|nucleus|cellular response to DNA damage stimulus|apoptotic signaling pathway|negative regulation of cell cycle process|cellular protein catabolic process|intrinsic apoptotic signaling pathway|dephosphorylation|regulation of cell cycle arrest|proteasomal protein catabolic process|protein processing|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|protein phosphatase type 2A regulator activity|mitotic cell cycle phase transition|mitotic DNA integrity checkpoint|DNA damage checkpoint|regulation of mitotic cell cycle phase transition|proteolysis involved in cellular protein catabolic process|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of cell cycle phase transition|cellular protein modification process|apoptotic process|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|regulation of phosphatase activity|positive regulation of cell cycle arrest|chromosome, centromeric region|protein dephosphorylation|regulation of protein dephosphorylation|regulation of G1/S transition of mitotic cell cycle|intrinsic apoptotic signaling pathway by p53 class mediator|mitotic G1/S transition checkpoint|modification-dependent protein catabolic process|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of phosphoprotein phosphatase activity|G1 DNA damage checkpoint|regulation of cell cycle G1/S phase transition|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic G1 DNA damage checkpoint|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|regulation of dephosphorylation|DNA damage response, signal transduction by p53 class mediator|proteasome-mediated ubiquitin-dependent protein catabolic process|signal transduction involved in DNA damage checkpoint|signal transduction involved in mitotic G1 DNA damage checkpoint|ubiquitin-dependent protein catabolic process|regulation of protein phosphatase type 2A activity K11584 serine/threonine-protein phosphatase 2A regulatory subunit B'[-] hsa04151|hsa04261|hsa04728|hsa04152|hsa04114|hsa04071|hsa03015 PI3K-Akt signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human) 14:101761798-101927989 1541 1863 2324 5002 5417 4814 3.92473138423393 4.31221271320644 5.33651333750433 11.4142837545177 11.3196778409062 11.4905894636193 4.52448581164823 11.4081836863477 -1.33424336577858 7.45700794014132e-11 2.00019330678328e-09 DOWN ENSG00000108239 TBC1D12 TBC1 domain family member 12 [Source:HGNC Symbol;Acc:HGNC:29082] GO:0008152|GO:0009893|GO:0030234|GO:0019222|GO:0008047|GO:0043085|GO:0050790|GO:0005096|GO:0051345|GO:0030695|GO:0043087|GO:0043547 metabolic process|positive regulation of metabolic process|enzyme regulator activity|regulation of metabolic process|enzyme activator activity|positive regulation of catalytic activity|regulation of catalytic activity|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|regulation of GTPase activity|positive regulation of GTPase activity - - - - 10:94402504-94535930 45 61 108 262 347 297 0.413453173793957 0.509359118259658 0.894639481826711 2.15680040512824 2.61582306396029 2.5573885522076 0.605817257960109 2.44333734043204 -2.01189848168533 7.57794933384771e-11 2.03080879185538e-09 DOWN ENSG00000145349 CAMK2D calcium/calmodulin-dependent protein kinase II delta [Source:HGNC Symbol;Acc:HGNC:1462] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0048523|GO:0031594|GO:0008283|GO:0098900|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0042175|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0005911|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0048589|GO:0016247|GO:0005622|GO:0002682|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0007507|GO:0060341|GO:0008284|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:0051282|GO:0042391|GO:0006935|GO:0045087|GO:0006725|GO:0009888|GO:0048468|GO:0043025|GO:0044325|GO:0006810|GO:0022402|GO:1901360|GO:0010941|GO:0033017|GO:0007275|GO:0016570|GO:0048513|GO:0044291|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0022607|GO:0010942|GO:0035265|GO:0061061|GO:0030315|GO:0055017|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0032970|GO:0003012|GO:0007267|GO:0003254|GO:0012506|GO:0009408|GO:0006928|GO:0042592|GO:0043005|GO:0098901|GO:0030666|GO:0009966|GO:0046983|GO:0042383|GO:0019725|GO:0036477|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0005516|GO:1902495|GO:0007154|GO:0044092|GO:0055085|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0005783|GO:0051649|GO:0008092|GO:2000021|GO:0009725|GO:0002026|GO:0008219|GO:0017080|GO:0001666|GO:0050790|GO:0000166|GO:0030030|GO:0032410|GO:0051238|GO:0002027|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0010035|GO:0009967|GO:0044249|GO:1903779|GO:0009266|GO:0010469|GO:0019538|GO:0023014|GO:0010033|GO:0001558|GO:0031323|GO:0016248|GO:0003013|GO:0034763|GO:0043271|GO:0006996|GO:0071774|GO:1900034|GO:0000165|GO:0051276|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0010468|GO:0006936|GO:0034645|GO:0048660|GO:0016528|GO:0010613|GO:0007166|GO:0051899|GO:0035639|GO:1903047|GO:0030424|GO:0043412|GO:0072358|GO:0034097|GO:0061337|GO:0031410|GO:0042692|GO:0031056|GO:0048878|GO:0051252|GO:0006325|GO:0019871|GO:0035051|GO:0030048|GO:0010644|GO:0032386|GO:0048738|GO:0001883|GO:0061049|GO:0050998|GO:0044770|GO:1901652|GO:0014704|GO:0043194|GO:0048659|GO:0055006|GO:0000904|GO:0090257|GO:0001508|GO:0071417|GO:0051208|GO:0010038|GO:0030334|GO:0016023|GO:0048661|GO:0008200|GO:0086091|GO:0051347|GO:0098909|GO:0036211|GO:0000278|GO:0060537|GO:0046907|GO:0006811|GO:0051209|GO:0032549|GO:0055082|GO:0044304|GO:1901844|GO:0032413|GO:0051279|GO:0010766|GO:0034341|GO:0031981|GO:0007346|GO:0043434|GO:0044344|GO:0010564|GO:0034605|GO:0034766|GO:0051247|GO:0048471|GO:0070848|GO:0031988|GO:0034765|GO:0005654|GO:0034702|GO:0002764|GO:0006461|GO:0016301|GO:0055001|GO:0010649|GO:0043269|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0090075|GO:0030659|GO:0071241|GO:0033043|GO:0044267|GO:0051174|GO:0010611|GO:0014896|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0031432|GO:0097485|GO:0017076|GO:0051246|GO:0009059|GO:0010522|GO:0030154|GO:0048858|GO:0030335|GO:0043068|GO:1902531|GO:0016070|GO:0072359|GO:0016773|GO:0008015|GO:0032870|GO:0016575|GO:0005634|GO:0060314|GO:0016529|GO:0042803|GO:0043067|GO:0022898|GO:0086065|GO:0034220|GO:0048666|GO:0006941|GO:0030182|GO:0008016|GO:0055002|GO:0007411|GO:0031063|GO:0098655|GO:0070252|GO:0086001|GO:0019221|GO:0031401|GO:0008543|GO:0043065|GO:0030139|GO:0071346|GO:0051259|GO:0006937|GO:1901653|GO:0043408|GO:0000086|GO:0055013|GO:0032774|GO:0005524|GO:0044772|GO:0060047|GO:0034703|GO:0014909|GO:0006812|GO:0051592|GO:2001141|GO:0010880|GO:0071363|GO:0030554|GO:2000650|GO:0016310|GO:0033044|GO:0014910|GO:0002768|GO:0038179|GO:1901077|GO:0014808|GO:0060402|GO:0070371|GO:0086004|GO:0061564|GO:0016482|GO:1901990|GO:0032412|GO:0007167|GO:0014911|GO:0055119|GO:0071375|GO:0043410|GO:0051146|GO:0042981|GO:0071345|GO:0050801|GO:0004672|GO:0016568|GO:1901725|GO:0032868|GO:1901987|GO:0051057|GO:0051056|GO:0014706|GO:0022008|GO:0048667|GO:0007264|GO:0055007|GO:0006464|GO:0019932|GO:0048812|GO:1902306|GO:0050848|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0090279|GO:0086064|GO:0071248|GO:0033674|GO:0070296|GO:0086003|GO:0048011|GO:0003300|GO:0000186|GO:1903169|GO:0006366|GO:0007265|GO:0010881|GO:0046578|GO:0045859|GO:0045860|GO:0010389|GO:0060333|GO:0006357|GO:0007409|GO:0006468|GO:0048699|GO:0071277|GO:1903506|GO:0046579|GO:0090311|GO:0006942|GO:0043405|GO:0060048|GO:0042325|GO:0070374|GO:0001932|GO:0032869|GO:0018193|GO:0038093|GO:0000082|GO:0034704|GO:0004674|GO:0055117|GO:0002028|GO:1901019|GO:1901897|GO:1902305|GO:0030001|GO:0001934|GO:0019722|GO:2000649|GO:0010657|GO:0051924|GO:1902749|GO:2001257|GO:0070372|GO:0030003|GO:0015672|GO:0042327|GO:0007268|GO:0007169|GO:0048010|GO:0035725|GO:0070588|GO:0010882|GO:0006814|GO:0055065|GO:1902514|GO:0046777|GO:0038095|GO:0016601|GO:0097553|GO:0006875|GO:0018105|GO:0006476|GO:0035022|GO:0071900|GO:0018107|GO:0004683|GO:0035020|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0030007|GO:0006874|GO:0055075|GO:0006816|GO:0010659|GO:0010666|GO:0055074|GO:0051480|GO:0032469|GO:0070509|GO:0060401|GO:0007204 locomotion|developmental process|growth|macromolecular complex|immune system process|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of cellular process|neuromuscular junction|cell proliferation|regulation of action potential|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cell-cell junction|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|developmental growth|channel regulator activity|intracellular|regulation of immune system process|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|heart development|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of sequestering of calcium ion|regulation of membrane potential|chemotaxis|innate immune response|cellular aromatic compound metabolic process|tissue development|cell development|neuronal cell body|ion channel binding|transport|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|sarcoplasmic reticulum membrane|multicellular organism development|histone modification|animal organ development|cell-cell contact zone|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|cellular component assembly|positive regulation of cell death|organ growth|muscle structure development|T-tubule|cardiac muscle tissue growth|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|muscle system process|cell-cell signaling|regulation of membrane depolarization|vesicle membrane|response to heat|movement of cell or subcellular component|homeostatic process|neuron projection|regulation of cardiac muscle cell action potential|endocytic vesicle membrane|regulation of signal transduction|protein dimerization activity|sarcolemma|cellular homeostasis|somatodendritic compartment|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|calmodulin binding|transmembrane transporter complex|cell communication|negative regulation of molecular function|transmembrane transport|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|endoplasmic reticulum|establishment of localization in cell|cytoskeletal protein binding|regulation of ion homeostasis|response to hormone|regulation of the force of heart contraction|cell death|sodium channel regulator activity|response to hypoxia|regulation of catalytic activity|nucleotide binding|cell projection organization|negative regulation of transporter activity|sequestering of metal ion|regulation of heart rate|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|regulation of cardiac conduction|response to temperature stimulus|regulation of receptor activity|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|channel inhibitor activity|circulatory system process|negative regulation of transmembrane transport|negative regulation of ion transport|organelle organization|response to fibroblast growth factor|regulation of cellular response to heat|MAPK cascade|chromosome organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|sarcoplasm|positive regulation of cardiac muscle hypertrophy|cell surface receptor signaling pathway|membrane depolarization|purine ribonucleoside triphosphate binding|mitotic cell cycle process|axon|macromolecule modification|cardiovascular system development|response to cytokine|cardiac conduction|cytoplasmic vesicle|muscle cell differentiation|regulation of histone modification|chemical homeostasis|regulation of RNA metabolic process|chromatin organization|sodium channel inhibitor activity|cardiocyte differentiation|actin filament-based movement|cell communication by electrical coupling|regulation of intracellular transport|cardiac muscle tissue development|purine nucleoside binding|cell growth involved in cardiac muscle cell development|nitric-oxide synthase binding|cell cycle phase transition|response to peptide|intercalated disc|axon initial segment|smooth muscle cell proliferation|cardiac cell development|cell morphogenesis involved in differentiation|regulation of muscle system process|action potential|cellular response to organonitrogen compound|sequestering of calcium ion|response to metal ion|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|positive regulation of smooth muscle cell proliferation|ion channel inhibitor activity|regulation of heart rate by cardiac conduction|positive regulation of transferase activity|regulation of cardiac muscle cell action potential involved in regulation of contraction|protein modification process|mitotic cell cycle|muscle tissue development|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|ribonucleoside binding|cellular chemical homeostasis|main axon|regulation of cell communication by electrical coupling involved in cardiac conduction|negative regulation of ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol|negative regulation of sodium ion transport|response to interferon-gamma|nuclear lumen|regulation of mitotic cell cycle|response to peptide hormone|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|cellular response to heat|negative regulation of ion transmembrane transport|positive regulation of protein metabolic process|perinuclear region of cytoplasm|response to growth factor|membrane-bounded vesicle|regulation of ion transmembrane transport|nucleoplasm|ion channel complex|immune response-regulating signaling pathway|protein complex assembly|kinase activity|muscle cell development|regulation of cell communication by electrical coupling|regulation of ion transport|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|relaxation of muscle|cytoplasmic vesicle membrane|cellular response to inorganic substance|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of cardiac muscle hypertrophy|muscle hypertrophy|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|titin binding|neuron projection guidance|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|blood circulation|cellular response to hormone stimulus|histone deacetylation|nucleus|regulation of ryanodine-sensitive calcium-release channel activity|sarcoplasmic reticulum|protein homodimerization activity|regulation of programmed cell death|regulation of transmembrane transporter activity|cell communication involved in cardiac conduction|ion transmembrane transport|neuron development|striated muscle contraction|neuron differentiation|regulation of heart contraction|striated muscle cell development|axon guidance|regulation of histone deacetylation|cation transmembrane transport|actin-mediated cell contraction|cardiac muscle cell action potential|cytokine-mediated signaling pathway|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|positive regulation of apoptotic process|endocytic vesicle|cellular response to interferon-gamma|protein oligomerization|regulation of muscle contraction|cellular response to peptide|regulation of MAPK cascade|G2/M transition of mitotic cell cycle|cardiac muscle cell development|RNA biosynthetic process|ATP binding|mitotic cell cycle phase transition|heart contraction|cation channel complex|smooth muscle cell migration|cation transport|response to calcium ion|regulation of RNA biosynthetic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|cellular response to growth factor stimulus|adenyl nucleotide binding|negative regulation of sodium ion transmembrane transporter activity|phosphorylation|regulation of chromosome organization|regulation of smooth muscle cell migration|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|regulation of relaxation of muscle|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|calcium ion transport into cytosol|ERK1 and ERK2 cascade|regulation of cardiac muscle cell contraction|axon development|cytosolic transport|regulation of mitotic cell cycle phase transition|regulation of ion transmembrane transporter activity|enzyme linked receptor protein signaling pathway|positive regulation of smooth muscle cell migration|relaxation of cardiac muscle|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|striated muscle cell differentiation|regulation of apoptotic process|cellular response to cytokine stimulus|ion homeostasis|protein kinase activity|chromatin modification|regulation of histone deacetylase activity|response to insulin|regulation of cell cycle phase transition|positive regulation of small GTPase mediated signal transduction|regulation of small GTPase mediated signal transduction|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cardiac muscle cell differentiation|cellular protein modification process|second-messenger-mediated signaling|neuron projection morphogenesis|negative regulation of sodium ion transmembrane transport|regulation of calcium-mediated signaling|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of calcium ion import|cell communication by electrical coupling involved in cardiac conduction|cellular response to metal ion|positive regulation of kinase activity|sarcoplasmic reticulum calcium ion transport|cardiac muscle cell contraction|neurotrophin TRK receptor signaling pathway|cardiac muscle hypertrophy|activation of MAPKK activity|regulation of calcium ion transmembrane transport|transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of G2/M transition of mitotic cell cycle|interferon-gamma-mediated signaling pathway|regulation of transcription from RNA polymerase II promoter|axonogenesis|protein phosphorylation|generation of neurons|cellular response to calcium ion|regulation of nucleic acid-templated transcription|positive regulation of Ras protein signal transduction|regulation of protein deacetylation|regulation of striated muscle contraction|regulation of MAP kinase activity|cardiac muscle contraction|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|G1/S transition of mitotic cell cycle|calcium channel complex|protein serine/threonine kinase activity|regulation of cardiac muscle contraction|regulation of sodium ion transport|regulation of calcium ion transmembrane transporter activity|regulation of relaxation of cardiac muscle|regulation of sodium ion transmembrane transport|metal ion transport|positive regulation of protein phosphorylation|calcium-mediated signaling|regulation of sodium ion transmembrane transporter activity|muscle cell apoptotic process|regulation of calcium ion transport|regulation of cell cycle G2/M phase transition|regulation of cation channel activity|regulation of ERK1 and ERK2 cascade|cellular cation homeostasis|monovalent inorganic cation transport|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|sodium ion transmembrane transport|calcium ion transmembrane transport|regulation of cardiac muscle contraction by calcium ion signaling|sodium ion transport|metal ion homeostasis|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|protein autophosphorylation|Fc-epsilon receptor signaling pathway|Rac protein signal transduction|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|peptidyl-serine phosphorylation|protein deacetylation|positive regulation of Rac protein signal transduction|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|calmodulin-dependent protein kinase activity|regulation of Rac protein signal transduction|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|cellular potassium ion homeostasis|cellular calcium ion homeostasis|potassium ion homeostasis|calcium ion transport|cardiac muscle cell apoptotic process|positive regulation of cardiac muscle cell apoptotic process|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|endoplasmic reticulum calcium ion homeostasis|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II[2.7.11.17] hsa04740|hsa05205|hsa04024|hsa04020|hsa05152|hsa04360|hsa04921|hsa04261|hsa04310|hsa04728|hsa04114|hsa04722|hsa04725|hsa04066|hsa04922|hsa04916|hsa04750|hsa04713|hsa04912|hsa04012|hsa04911|hsa04925|hsa04971|hsa05031|hsa04720|hsa05214 Olfactory transduction - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Glioma - Homo sapiens (human) 4:113451032-113761927 118 141 264 604 624 1063 0.594639737378134 0.645760491401772 1.19946843974184 2.72713205174092 2.5800256016081 5.02034351573089 0.813289556173915 3.4425003896933 -2.08161582485795 7.80145745943408e-11 2.08883148873493e-09 DOWN ENSG00000144452 ABCA12 ATP binding cassette subfamily A member 12 [Source:HGNC Symbol;Acc:HGNC:14637] GO:0032502|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0050794|GO:0043229|GO:0051050|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0060341|GO:0048286|GO:0019866|GO:0009888|GO:0006810|GO:0035295|GO:0007275|GO:0030324|GO:0048513|GO:0005102|GO:0043168|GO:0032940|GO:0001882|GO:0031982|GO:0016817|GO:0030141|GO:0043231|GO:0005737|GO:0032880|GO:0042592|GO:2000010|GO:0031424|GO:0031966|GO:0019725|GO:0005319|GO:0030323|GO:0048871|GO:0008104|GO:0055085|GO:0061024|GO:0000166|GO:0048869|GO:0016021|GO:0010876|GO:0010256|GO:0050878|GO:0032370|GO:0016192|GO:0005740|GO:0016820|GO:0005829|GO:0035639|GO:0031410|GO:0050891|GO:0048878|GO:0001894|GO:0060541|GO:0001883|GO:0007009|GO:0016023|GO:0006887|GO:0016818|GO:0042886|GO:0006811|GO:0032549|GO:0005743|GO:0072657|GO:0032368|GO:0042599|GO:0006869|GO:0031988|GO:0005739|GO:0043588|GO:0034613|GO:0060429|GO:0046903|GO:0017076|GO:0030154|GO:1903827|GO:0034190|GO:0034040|GO:0015914|GO:2000008|GO:0006820|GO:0015711|GO:0032376|GO:0045055|GO:0030855|GO:0072659|GO:0005524|GO:0030216|GO:0030554|GO:0061436|GO:0008544|GO:0030104|GO:0034394|GO:0048875|GO:0015918|GO:0055088|GO:0097209|GO:0035627|GO:0034191|GO:0042626|GO:0033561|GO:1990778|GO:0016462|GO:0010875|GO:0032374|GO:0017111|GO:0043129|GO:0030301|GO:0033700|GO:0009913|GO:0016887|GO:0033344|GO:0010874|GO:0042623|GO:0043492 developmental process|transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|regulation of cellular process|intracellular organelle|positive regulation of transport|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of cellular localization|lung alveolus development|organelle inner membrane|tissue development|transport|tube development|multicellular organism development|lung development|animal organ development|receptor binding|anion binding|secretion by cell|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|secretory granule|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|homeostatic process|positive regulation of protein localization to cell surface|keratinization|mitochondrial membrane|cellular homeostasis|lipid transporter activity|respiratory tube development|multicellular organismal homeostasis|protein localization|transmembrane transport|membrane organization|nucleotide binding|cellular developmental process|integral component of membrane|lipid localization|endomembrane system organization|regulation of body fluid levels|positive regulation of lipid transport|vesicle-mediated transport|mitochondrial envelope|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|cytosol|purine ribonucleoside triphosphate binding|cytoplasmic vesicle|multicellular organismal water homeostasis|chemical homeostasis|tissue homeostasis|respiratory system development|purine nucleoside binding|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|exocytosis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|amide transport|ion transport|ribonucleoside binding|mitochondrial inner membrane|protein localization to membrane|regulation of lipid transport|lamellar body|lipid transport|membrane-bounded vesicle|mitochondrion|skin development|cellular protein localization|epithelium development|secretion|purine nucleotide binding|cell differentiation|regulation of cellular protein localization|apolipoprotein receptor binding|lipid-transporting ATPase activity|phospholipid transport|regulation of protein localization to cell surface|anion transport|organic anion transport|positive regulation of cholesterol transport|regulated exocytosis|epithelial cell differentiation|protein localization to plasma membrane|ATP binding|keratinocyte differentiation|adenyl nucleotide binding|establishment of skin barrier|epidermis development|water homeostasis|protein localization to cell surface|chemical homeostasis within a tissue|sterol transport|lipid homeostasis|epidermal lamellar body|ceramide transport|apolipoprotein A-I receptor binding|ATPase activity, coupled to transmembrane movement of substances|regulation of water loss via skin|protein localization to cell periphery|pyrophosphatase activity|positive regulation of cholesterol efflux|regulation of cholesterol transport|nucleoside-triphosphatase activity|surfactant homeostasis|cholesterol transport|phospholipid efflux|epidermal cell differentiation|ATPase activity|cholesterol efflux|regulation of cholesterol efflux|ATPase activity, coupled|ATPase activity, coupled to movement of substances K05646 ATP-binding cassette, subfamily A (ABC1), member 12[-] hsa02010 ABC transporters - Homo sapiens (human) 2:214931542-215138428 30 27 49 132 172 226 0.214849969565035 0.175740364563404 0.316394089835816 0.847019952541663 1.01068888981346 1.5169061868609 0.235661474654752 1.12487167640534 -2.2549725956248 7.81530540153271e-11 2.09066422452829e-09 DOWN ENSG00000166889 PATL1 protein associated with topoisomerase II homolog 1 (yeast) [Source:HGNC Symbol;Acc:HGNC:26721] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0030014|GO:0005737|GO:0030529|GO:0006139|GO:0022613|GO:0006996|GO:0035770|GO:0005829|GO:0003723|GO:0044265|GO:0022618|GO:0031981|GO:0005654|GO:0070925|GO:0010467|GO:0019439|GO:0016070|GO:0005634|GO:0036464|GO:0006401|GO:0034622|GO:0016604|GO:0016071|GO:0044822|GO:0033962|GO:0003727|GO:0000932|GO:0016607|GO:0006402|GO:0016605|GO:0008187|GO:0000956|GO:0008266|GO:0034046|GO:0000291|GO:0000290|GO:0000288|GO:0043928 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|CCR4-NOT complex|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|organelle organization|ribonucleoprotein granule|cytosol|RNA binding|cellular macromolecule catabolic process|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|organelle assembly|gene expression|aromatic compound catabolic process|RNA metabolic process|nucleus|cytoplasmic ribonucleoprotein granule|RNA catabolic process|cellular macromolecular complex assembly|nuclear body|mRNA metabolic process|poly(A) RNA binding|cytoplasmic mRNA processing body assembly|single-stranded RNA binding|cytoplasmic mRNA processing body|nuclear speck|mRNA catabolic process|PML body|poly-pyrimidine tract binding|nuclear-transcribed mRNA catabolic process|poly(U) RNA binding|poly(G) binding|nuclear-transcribed mRNA catabolic process, exonucleolytic|deadenylation-dependent decapping of nuclear-transcribed mRNA|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay K12617 DNA topoisomerase 2-associated protein PAT1[-] hsa03018 RNA degradation - Homo sapiens (human) 11:59636716-59668980 2362 2532 2640 1070 1308 1138 37.0302367496868 36.0761729302897 37.3159689450304 15.0299654329963 16.8248938917408 16.7204404885632 36.807459541669 16.1917666044334 1.18473777842825 8.00352670819439e-11 2.13909835583201e-09 UP ENSG00000271971 CTD-2006H14.2 - - - - - - - 8:93715378-93716113 9 13 15 61 81 67 0.864993474195563 1.13555074957306 1.29977908393184 5.25281482810707 6.38734672163028 6.03493080748686 1.10010776923349 5.89169745240807 -2.42103848711041 8.02507339653763e-11 2.142938650986e-09 DOWN ENSG00000151632 AKR1C2 aldo-keto reductase family 1, member C2 [Source:HGNC Symbol;Acc:HGNC:385] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0016491|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0042445|GO:0023051|GO:0008289|GO:0005622|GO:0048856|GO:0008284|GO:0042127|GO:0044255|GO:0009888|GO:1901360|GO:0006082|GO:0005496|GO:0043168|GO:0044281|GO:0016614|GO:0005737|GO:0016705|GO:0043177|GO:0009966|GO:0030638|GO:0051186|GO:0010646|GO:0016651|GO:0004497|GO:0007154|GO:0006629|GO:0007165|GO:0008207|GO:0042180|GO:0016627|GO:0007586|GO:0009725|GO:0010817|GO:0048869|GO:0009967|GO:0010033|GO:0055114|GO:1902533|GO:0007186|GO:0033993|GO:0032052|GO:0044597|GO:0006631|GO:0016709|GO:0016616|GO:0044598|GO:0016655|GO:0042448|GO:0008202|GO:0070542|GO:0060429|GO:0035556|GO:0031406|GO:0016628|GO:1901661|GO:0071310|GO:0030154|GO:1902531|GO:0032870|GO:0006690|GO:0016137|GO:0018636|GO:0051896|GO:0043491|GO:0033559|GO:0047115|GO:0071395|GO:0071398|GO:0030855|GO:0051897|GO:0019752|GO:0047086|GO:0004033|GO:0071379|GO:0071396|GO:0008106|GO:0071799|GO:0032787|GO:0006693|GO:0004032 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|oxidoreductase activity|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|hormone metabolic process|regulation of signaling|lipid binding|intracellular|anatomical structure development|positive regulation of cell proliferation|regulation of cell proliferation|cellular lipid metabolic process|tissue development|organic cyclic compound metabolic process|organic acid metabolic process|steroid binding|anion binding|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|organic acid binding|regulation of signal transduction|polyketide metabolic process|cofactor metabolic process|regulation of cell communication|oxidoreductase activity, acting on NAD(P)H|monooxygenase activity|cell communication|lipid metabolic process|signal transduction|C21-steroid hormone metabolic process|cellular ketone metabolic process|oxidoreductase activity, acting on the CH-CH group of donors|digestion|response to hormone|regulation of hormone levels|cellular developmental process|positive regulation of signal transduction|response to organic substance|oxidation-reduction process|positive regulation of intracellular signal transduction|G-protein coupled receptor signaling pathway|response to lipid|bile acid binding|daunorubicin metabolic process|fatty acid metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|doxorubicin metabolic process|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|progesterone metabolic process|steroid metabolic process|response to fatty acid|epithelium development|intracellular signal transduction|carboxylic acid binding|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|quinone metabolic process|cellular response to organic substance|cell differentiation|regulation of intracellular signal transduction|cellular response to hormone stimulus|icosanoid metabolic process|glycoside metabolic process|phenanthrene 9,10-monooxygenase activity|regulation of protein kinase B signaling|protein kinase B signaling|unsaturated fatty acid metabolic process|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity|cellular response to jasmonic acid stimulus|cellular response to fatty acid|epithelial cell differentiation|positive regulation of protein kinase B signaling|carboxylic acid metabolic process|ketosteroid monooxygenase activity|aldo-keto reductase (NADP) activity|cellular response to prostaglandin stimulus|cellular response to lipid|alcohol dehydrogenase (NADP+) activity|cellular response to prostaglandin D stimulus|monocarboxylic acid metabolic process|prostaglandin metabolic process|alditol:NADP+ 1-oxidoreductase activity K00089 3alpha-hydroxysteroid 3-dehydrogenase[1.1.1.357] hsa05204|hsa00140 Chemical carcinogenesis - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human) 10:4922564-5135226 3151 3785 2861 9184 9415 12640 23.1071767248777 25.2257695459791 18.9160516540851 60.3431609131541 56.6482866630062 86.8709343319465 22.4163326416473 67.9541273027023 -1.60001090848859 8.14090718670188e-11 2.17192710591419e-09 DOWN ENSG00000184304 PRKD1 protein kinase D1 [Source:HGNC Symbol;Acc:HGNC:9407] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0048520|GO:0071704|GO:0043167|GO:0006955|GO:0051051|GO:0044237|GO:0051641|GO:0050795|GO:0048870|GO:0023051|GO:0005911|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0060341|GO:0008284|GO:0051272|GO:0042127|GO:0044255|GO:0051282|GO:0006935|GO:0045087|GO:0045595|GO:0006725|GO:0048468|GO:0006810|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0005938|GO:0007275|GO:0010632|GO:0060627|GO:0016570|GO:0034641|GO:0043168|GO:0045806|GO:0044281|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0005887|GO:0045597|GO:0043231|GO:0043169|GO:0005737|GO:0050920|GO:0006928|GO:0042592|GO:0009966|GO:0050673|GO:0019725|GO:0006979|GO:0060548|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0001525|GO:0007154|GO:0045778|GO:0055085|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0030278|GO:0001503|GO:0051649|GO:2000021|GO:0008219|GO:0010634|GO:0050790|GO:0000166|GO:0030030|GO:0051238|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0010256|GO:0005794|GO:0050921|GO:0006996|GO:0051090|GO:0016192|GO:0050679|GO:0051276|GO:1902533|GO:0032268|GO:0005829|GO:0031175|GO:0031344|GO:0010468|GO:0090132|GO:0034645|GO:0006665|GO:0005802|GO:0046872|GO:0007166|GO:0035639|GO:0001944|GO:0043412|GO:0007030|GO:0072358|GO:0051345|GO:0010720|GO:0031056|GO:0048878|GO:0051252|GO:0006325|GO:0032386|GO:0001883|GO:0045667|GO:0031346|GO:0031058|GO:0051208|GO:0006643|GO:0010628|GO:0030334|GO:0038089|GO:0001935|GO:0001667|GO:0036211|GO:0046907|GO:0006811|GO:0006954|GO:0051209|GO:0032549|GO:0055082|GO:0001649|GO:0051091|GO:0045766|GO:0051279|GO:0060326|GO:0050769|GO:0045765|GO:2001028|GO:0034599|GO:0030100|GO:0051247|GO:0070848|GO:0034765|GO:0050678|GO:0016301|GO:0045669|GO:0043269|GO:0032270|GO:0012501|GO:2001044|GO:0006796|GO:1901342|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0008610|GO:0007399|GO:0071310|GO:0017076|GO:0010594|GO:0031328|GO:0051246|GO:0009059|GO:0010522|GO:0030154|GO:0030335|GO:1902531|GO:0016070|GO:0072359|GO:0043616|GO:0016773|GO:0010557|GO:0016575|GO:0005634|GO:0051960|GO:0010595|GO:0034220|GO:0010638|GO:0048666|GO:2001252|GO:0030182|GO:0031063|GO:0043536|GO:0010837|GO:0045893|GO:0098655|GO:0010975|GO:0031401|GO:0043122|GO:0032774|GO:0005524|GO:0031065|GO:0006812|GO:2001141|GO:0090045|GO:0071363|GO:0030554|GO:0043535|GO:0016310|GO:0007229|GO:0033044|GO:0051092|GO:0048193|GO:0060402|GO:0035767|GO:0016482|GO:0001936|GO:0007167|GO:0043123|GO:0007249|GO:0032793|GO:0010631|GO:0050801|GO:0001938|GO:0004672|GO:0016568|GO:1901725|GO:0038033|GO:0006897|GO:0022008|GO:0030148|GO:0006464|GO:0050767|GO:0010976|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0090279|GO:0089700|GO:0045666|GO:1903169|GO:0045944|GO:0006366|GO:0090312|GO:0006357|GO:0006468|GO:0048699|GO:1903506|GO:0090311|GO:0042325|GO:0035924|GO:0001932|GO:0018193|GO:0004674|GO:0030001|GO:0001934|GO:0051924|GO:1901727|GO:0043542|GO:0045664|GO:0030003|GO:0042327|GO:0007169|GO:0048010|GO:0070588|GO:0055065|GO:0046777|GO:0033138|GO:0097553|GO:0006875|GO:0018105|GO:0006476|GO:0033135|GO:0004697|GO:0038084|GO:0043534|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 locomotion|developmental process|immune system process|behavior|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of behavior|organic substance metabolic process|ion binding|immune response|negative regulation of transport|cellular metabolic process|cellular localization|regulation of behavior|cell motility|regulation of signaling|cell-cell junction|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|cellular lipid metabolic process|regulation of sequestering of calcium ion|chemotaxis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|cell cortex|multicellular organism development|regulation of epithelial cell migration|regulation of vesicle-mediated transport|histone modification|cellular nitrogen compound metabolic process|anion binding|negative regulation of endocytosis|small molecule metabolic process|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|integral component of plasma membrane|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|cytoplasm|regulation of chemotaxis|movement of cell or subcellular component|homeostatic process|regulation of signal transduction|epithelial cell proliferation|cellular homeostasis|response to oxidative stress|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|angiogenesis|cell communication|positive regulation of ossification|transmembrane transport|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|regulation of ossification|ossification|establishment of localization in cell|regulation of ion homeostasis|cell death|positive regulation of epithelial cell migration|regulation of catalytic activity|nucleotide binding|cell projection organization|sequestering of metal ion|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|positive regulation of chemotaxis|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|vesicle-mediated transport|positive regulation of epithelial cell proliferation|chromosome organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|neuron projection development|regulation of cell projection organization|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|sphingolipid metabolic process|trans-Golgi network|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|vasculature development|macromolecule modification|Golgi organization|cardiovascular system development|positive regulation of hydrolase activity|positive regulation of cell development|regulation of histone modification|chemical homeostasis|regulation of RNA metabolic process|chromatin organization|regulation of intracellular transport|purine nucleoside binding|regulation of osteoblast differentiation|positive regulation of cell projection organization|positive regulation of histone modification|sequestering of calcium ion|membrane lipid metabolic process|positive regulation of gene expression|regulation of cell migration|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|endothelial cell proliferation|ameboidal-type cell migration|protein modification process|intracellular transport|ion transport|inflammatory response|release of sequestered calcium ion into cytosol|ribonucleoside binding|cellular chemical homeostasis|osteoblast differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of angiogenesis|regulation of release of sequestered calcium ion into cytosol|cell chemotaxis|positive regulation of neurogenesis|regulation of angiogenesis|positive regulation of endothelial cell chemotaxis|cellular response to oxidative stress|regulation of endocytosis|positive regulation of protein metabolic process|response to growth factor|regulation of ion transmembrane transport|regulation of epithelial cell proliferation|kinase activity|positive regulation of osteoblast differentiation|regulation of ion transport|positive regulation of cellular protein metabolic process|programmed cell death|regulation of integrin-mediated signaling pathway|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|lipid biosynthetic process|nervous system development|cellular response to organic substance|purine nucleotide binding|regulation of endothelial cell migration|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|cell differentiation|positive regulation of cell migration|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|keratinocyte proliferation|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|regulation of nervous system development|positive regulation of endothelial cell migration|ion transmembrane transport|positive regulation of organelle organization|neuron development|positive regulation of chromosome organization|neuron differentiation|regulation of histone deacetylation|positive regulation of blood vessel endothelial cell migration|regulation of keratinocyte proliferation|positive regulation of transcription, DNA-templated|cation transmembrane transport|regulation of neuron projection development|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|RNA biosynthetic process|ATP binding|positive regulation of histone deacetylation|cation transport|regulation of RNA biosynthetic process|positive regulation of deacetylase activity|cellular response to growth factor stimulus|adenyl nucleotide binding|regulation of blood vessel endothelial cell migration|phosphorylation|integrin-mediated signaling pathway|regulation of chromosome organization|positive regulation of NF-kappaB transcription factor activity|Golgi vesicle transport|calcium ion transport into cytosol|endothelial cell chemotaxis|cytosolic transport|regulation of endothelial cell proliferation|enzyme linked receptor protein signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|positive regulation of CREB transcription factor activity|epithelial cell migration|ion homeostasis|positive regulation of endothelial cell proliferation|protein kinase activity|chromatin modification|regulation of histone deacetylase activity|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|endocytosis|neurogenesis|sphingolipid biosynthetic process|cellular protein modification process|regulation of neurogenesis|positive regulation of neuron projection development|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of calcium ion import|protein kinase D signaling|positive regulation of neuron differentiation|regulation of calcium ion transmembrane transport|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|positive regulation of protein deacetylation|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of protein deacetylation|regulation of phosphorylation|cellular response to vascular endothelial growth factor stimulus|regulation of protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|metal ion transport|positive regulation of protein phosphorylation|regulation of calcium ion transport|positive regulation of histone deacetylase activity|endothelial cell migration|regulation of neuron differentiation|cellular cation homeostasis|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|calcium ion transmembrane transport|metal ion homeostasis|protein autophosphorylation|positive regulation of peptidyl-serine phosphorylation|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|peptidyl-serine phosphorylation|protein deacetylation|regulation of peptidyl-serine phosphorylation|protein kinase C activity|vascular endothelial growth factor signaling pathway|blood vessel endothelial cell migration|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K06070 protein kinase D[2.7.11.13] hsa04015|hsa04925 Rap1 signaling pathway - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human) 14:29576479-30191898 19 24 42 129 127 136 0.16496511924507 0.189382011770918 0.328785004972165 1.00354013186786 0.904729744571183 1.10666375836211 0.227710711996051 1.00497787826705 -2.14188967929522 8.23979198697903e-11 2.19634598195779e-09 DOWN ENSG00000130479 MAP1S microtubule associated protein 1S [Source:HGNC Symbol;Acc:HGNC:15715] GO:0032502|GO:0045202|GO:0005623|GO:0009987|GO:0030054|GO:0005488|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0051641|GO:0006914|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0042802|GO:0051640|GO:0048468|GO:0043025|GO:0006810|GO:0007275|GO:0003676|GO:0048513|GO:0005874|GO:0051128|GO:0007420|GO:0043231|GO:0005737|GO:0060322|GO:0006928|GO:0032403|GO:0051656|GO:0043005|GO:0036477|GO:0010970|GO:0051649|GO:0008092|GO:0008219|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0051276|GO:0005730|GO:0015631|GO:0051646|GO:0000902|GO:0005829|GO:0031175|GO:0003677|GO:0007010|GO:0007417|GO:0006325|GO:0051654|GO:0003779|GO:0008017|GO:0046907|GO:0031981|GO:0030425|GO:0007018|GO:0048471|GO:0051015|GO:0012501|GO:0033043|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0000226|GO:0072384|GO:0005856|GO:0005634|GO:0005819|GO:0048666|GO:0030182|GO:0010848|GO:0048487|GO:0047497|GO:0033044|GO:0006333|GO:0015630|GO:0001578|GO:0022008|GO:0030705|GO:0048812|GO:0006915|GO:0048699|GO:0001672 developmental process|synapse|cell|cellular process|cell junction|binding|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|cellular localization|autophagy|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|identical protein binding|organelle localization|cell development|neuronal cell body|transport|multicellular organism development|nucleic acid binding|animal organ development|microtubule|regulation of cellular component organization|brain development|intracellular membrane-bounded organelle|cytoplasm|head development|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|neuron projection|somatodendritic compartment|establishment of localization by movement along microtubule|establishment of localization in cell|cytoskeletal protein binding|cell death|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|chromosome organization|nucleolus|tubulin binding|mitochondrion localization|cell morphogenesis|cytosol|neuron projection development|DNA binding|cytoskeleton organization|central nervous system development|chromatin organization|establishment of mitochondrion localization|actin binding|microtubule binding|intracellular transport|nuclear lumen|dendrite|microtubule-based movement|perinuclear region of cytoplasm|actin filament binding|programmed cell death|regulation of organelle organization|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|microtubule cytoskeleton organization|organelle transport along microtubule|cytoskeleton|nucleus|spindle|neuron development|neuron differentiation|regulation of chromatin disassembly|beta-tubulin binding|mitochondrion transport along microtubule|regulation of chromosome organization|chromatin assembly or disassembly|microtubule cytoskeleton|microtubule bundle formation|neurogenesis|cytoskeleton-dependent intracellular transport|neuron projection morphogenesis|apoptotic process|generation of neurons|regulation of chromatin assembly or disassembly - - - - 19:17719242-17734516 1687 1783 1798 796 814 825 10.6433333466632 10.2233688664173 10.2274289880639 4.49959217653543 4.21361636284225 4.87803960590496 10.3647104003815 4.53041604842755 1.19396435614832 8.37868318877286e-11 2.23137562816793e-09 UP ENSG00000170876 TMEM43 transmembrane protein 43 [Source:HGNC Symbol;Acc:HGNC:28472] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019866|GO:0043231|GO:0005737|GO:0005635|GO:0061024|GO:0005783|GO:0043621|GO:0031965|GO:0016021|GO:0031301|GO:0010256|GO:0005794|GO:0006996|GO:0006998|GO:0005639|GO:0071763|GO:0005637|GO:0005788|GO:0006997|GO:0005634 cell|membrane|cellular process|binding|intracellular organelle|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|organelle inner membrane|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|membrane organization|endoplasmic reticulum|protein self-association|nuclear membrane|integral component of membrane|integral component of organelle membrane|endomembrane system organization|Golgi apparatus|organelle organization|nuclear envelope organization|integral component of nuclear inner membrane|nuclear membrane organization|nuclear inner membrane|endoplasmic reticulum lumen|nucleus organization|nucleus - - - - 3:14124940-14143679 494 523 977 2032 2156 2023 9.15004886622571 8.80395114218675 16.3156641702337 33.7223180043648 32.7651913635391 35.1172863059622 11.4232213928821 33.868265224622 -1.56796453836716 8.4298993478384e-11 2.24301439510132e-09 DOWN ENSG00000174606 ANGEL2 angel homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:30534] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0043227|GO:0005622|GO:0019222|GO:0051726|GO:0007049|GO:0003676|GO:0045786|GO:0043231|GO:0005737|GO:0043487|GO:0010468|GO:0003723|GO:0000278|GO:0031981|GO:0007346|GO:0045930|GO:0005654|GO:0010467|GO:0005634|GO:0043488|GO:0048255|GO:0010608|GO:0016604|GO:0044822|GO:0070935|GO:0015030|GO:0003729|GO:0003730 cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|membrane-bounded organelle|intracellular|regulation of metabolic process|regulation of cell cycle|cell cycle|nucleic acid binding|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|regulation of RNA stability|regulation of gene expression|RNA binding|mitotic cell cycle|nuclear lumen|regulation of mitotic cell cycle|negative regulation of mitotic cell cycle|nucleoplasm|gene expression|nucleus|regulation of mRNA stability|mRNA stabilization|posttranscriptional regulation of gene expression|nuclear body|poly(A) RNA binding|3'-UTR-mediated mRNA stabilization|Cajal body|mRNA binding|mRNA 3'-UTR binding - - - - 1:212992182-213015826 201 208 188 720 764 508 1.31090500014712 1.23287468490194 1.10547114453379 4.20732758987939 4.08825225434688 3.10505160030471 1.21641694319428 3.80021048151033 -1.64344151044397 8.5210444475893e-11 2.26524720336893e-09 DOWN ENSG00000106443 PHF14 PHD finger protein 14 [Source:HGNC Symbol;Acc:HGNC:22203] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0023057|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0042127|GO:0048286|GO:0006725|GO:0035295|GO:1901360|GO:0007275|GO:0030324|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0009966|GO:0009890|GO:0030323|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0008285|GO:2000791|GO:0044249|GO:0031324|GO:0031323|GO:0072089|GO:0010468|GO:0034645|GO:0046872|GO:0007166|GO:0010629|GO:0051252|GO:0060541|GO:0010463|GO:0010640|GO:2000647|GO:0010642|GO:0060916|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0072091|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0007167|GO:0072201|GO:2000584|GO:0046914|GO:0006351|GO:0006355|GO:0010464|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122|GO:0008270|GO:0007169|GO:0048008|GO:0035790 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|lung alveolus development|cellular aromatic compound metabolic process|tube development|organic cyclic compound metabolic process|multicellular organism development|lung development|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|regulation of signal transduction|negative regulation of biosynthetic process|respiratory tube development|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|negative regulation of cell proliferation|negative regulation of mesenchymal cell proliferation involved in lung development|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|stem cell proliferation|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|negative regulation of gene expression|regulation of RNA metabolic process|respiratory system development|mesenchymal cell proliferation|regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of stem cell proliferation|negative regulation of platelet-derived growth factor receptor signaling pathway|mesenchymal cell proliferation involved in lung development|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulation of stem cell proliferation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|enzyme linked receptor protein signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of platelet-derived growth factor receptor-alpha signaling pathway|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of mesenchymal cell proliferation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|transmembrane receptor protein tyrosine kinase signaling pathway|platelet-derived growth factor receptor signaling pathway|platelet-derived growth factor receptor-alpha signaling pathway - - - - 7:10973872-11169630 125 177 126 567 569 411 0.692576647974345 0.891273039292956 0.629422284524531 2.81473778030488 2.58664813699443 2.13416594901009 0.737757323930611 2.51185062210313 -1.76753242788207 8.5428799753803e-11 2.26903148385234e-09 DOWN ENSG00000174307 PHLDA3 pleckstrin homology-like domain, family A, member 3 [Source:HGNC Symbol;Acc:HGNC:8934] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0006950|GO:0043167|GO:0023051|GO:0009653|GO:0043227|GO:0008289|GO:0071944|GO:0023057|GO:0005622|GO:0005886|GO:0048856|GO:0010941|GO:0043168|GO:0005543|GO:0031982|GO:0033554|GO:0010942|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0008219|GO:0035091|GO:0012501|GO:0035556|GO:1902532|GO:0043068|GO:1902531|GO:0043067|GO:0006974|GO:0097190|GO:0051896|GO:0043491|GO:0097193|GO:0051898|GO:0043065|GO:0072331|GO:1901981|GO:0008630|GO:0042981|GO:0006915|GO:0072332|GO:1902936|GO:0042771|GO:0032266|GO:0005547|GO:0010314|GO:0080025|GO:0005546|GO:0043325 developmental process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|response to stress|ion binding|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|lipid binding|cell periphery|negative regulation of signaling|intracellular|plasma membrane|anatomical structure development|regulation of cell death|anion binding|phospholipid binding|vesicle|cellular response to stress|positive regulation of cell death|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|cell death|phosphatidylinositol binding|programmed cell death|intracellular signal transduction|negative regulation of intracellular signal transduction|positive regulation of programmed cell death|regulation of intracellular signal transduction|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|regulation of protein kinase B signaling|protein kinase B signaling|intrinsic apoptotic signaling pathway|negative regulation of protein kinase B signaling|positive regulation of apoptotic process|signal transduction by p53 class mediator|phosphatidylinositol phosphate binding|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of apoptotic process|apoptotic process|intrinsic apoptotic signaling pathway by p53 class mediator|phosphatidylinositol bisphosphate binding|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding - - - - 1:201464383-201469237 111 122 290 1012 670 694 1.64297759415469 1.64114895451904 3.87009161761263 13.4210593887648 8.13675777603566 9.62713740650122 2.38473938876212 10.3949848571006 -2.12398413849234 8.61467995366232e-11 2.28606804743676e-09 DOWN ENSG00000049239 H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:HGNC Symbol;Acc:HGNC:4795] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0030246|GO:0043227|GO:0048037|GO:0016787|GO:0005622|GO:0012505|GO:0006081|GO:0006725|GO:1901360|GO:0034641|GO:0016788|GO:0044281|GO:0019637|GO:0046483|GO:0016614|GO:0043231|GO:0005737|GO:0005975|GO:0051186|GO:0006139|GO:0055086|GO:0005783|GO:0050662|GO:0000166|GO:0010033|GO:0055114|GO:0019693|GO:0050661|GO:0016616|GO:0005996|GO:0005739|GO:0051156|GO:0006796|GO:0005788|GO:0052689|GO:0097305|GO:0019682|GO:0019318|GO:0006098|GO:0009117|GO:0017057|GO:0004345|GO:0047936|GO:0006006|GO:0006739 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|cofactor binding|hydrolase activity|intracellular|endomembrane system|cellular aldehyde metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|endoplasmic reticulum|coenzyme binding|nucleotide binding|response to organic substance|oxidation-reduction process|ribose phosphate metabolic process|NADP binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|monosaccharide metabolic process|mitochondrion|glucose 6-phosphate metabolic process|phosphate-containing compound metabolic process|endoplasmic reticulum lumen|carboxylic ester hydrolase activity|response to alcohol|glyceraldehyde-3-phosphate metabolic process|hexose metabolic process|pentose-phosphate shunt|nucleotide metabolic process|6-phosphogluconolactonase activity|glucose-6-phosphate dehydrogenase activity|glucose 1-dehydrogenase [NAD(P)] activity|glucose metabolic process|NADP metabolic process K13937 hexose-6-phosphate dehydrogenase[3.1.1.31] hsa01100|hsa01200|hsa00030 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Pentose phosphate pathway - Homo sapiens (human) 1:9234775-9271337 238 276 414 829 903 1036 1.02579716750244 1.08111719314058 1.60878905941397 3.20137482087709 3.19330278478767 4.18478157780069 1.23856780668566 3.52648639448848 -1.50955862108137 8.66021091256707e-11 2.29610956113479e-09 DOWN ENSG00000182836 PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 [Source:HGNC Symbol;Acc:HGNC:31822] GO:0004871|GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0050794|GO:0071704|GO:0009056|GO:0016787|GO:0016788|GO:0007154|GO:0006629|GO:0007165|GO:0016042|GO:0042578|GO:0008081 signal transducer activity|signaling|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|catabolic process|hydrolase activity|hydrolase activity, acting on ester bonds|cell communication|lipid metabolic process|signal transduction|lipid catabolic process|phosphoric ester hydrolase activity|phosphoric diester hydrolase activity - - - - 5:41306954-41510628 70 85 233 599 610 941 0.340710671521245 0.376002965759222 1.02249494249561 2.6122535200137 2.43606157790446 4.29248701298612 0.579736193258692 3.11360070363476 -2.42511547945801 8.69032490343615e-11 2.30204933156329e-09 DOWN ENSG00000083817 ZNF416 zinc finger protein 416 [Source:HGNC Symbol;Acc:HGNC:20645] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57571566-57578927 624 656 439 182 204 210 17.2353757786298 16.4672124221731 10.9323951459754 4.50407280951646 4.62310962456141 5.43606772670084 14.8783277822594 4.85441672025957 1.61584252199217 8.7339753871656e-11 2.3115611809259e-09 UP ENSG00000197081 IGF2R insulin like growth factor 2 receptor [Source:HGNC Symbol;Acc:HGNC:5467] GO:0032502|GO:0032991|GO:0004871|GO:0000003|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0004872|GO:0030055|GO:0050794|GO:0043229|GO:0044702|GO:0043167|GO:0009986|GO:0019953|GO:0038023|GO:0030246|GO:0043227|GO:0008289|GO:0071944|GO:0032504|GO:0031224|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0048609|GO:0042802|GO:0051219|GO:0019840|GO:0048029|GO:0009791|GO:0019838|GO:0006810|GO:0010941|GO:0007275|GO:0048513|GO:0043168|GO:0005924|GO:0005912|GO:0016772|GO:0031982|GO:0030117|GO:0010942|GO:0005887|GO:0043231|GO:0030133|GO:0019899|GO:0004888|GO:0005774|GO:0005737|GO:0001965|GO:0005635|GO:0043177|GO:0031226|GO:0007154|GO:0007276|GO:0007165|GO:0070062|GO:0008219|GO:0005641|GO:0001948|GO:0016021|GO:0010033|GO:0048732|GO:0005794|GO:0005768|GO:0016192|GO:0007186|GO:0005798|GO:0005520|GO:0005802|GO:0048232|GO:0007166|GO:0033993|GO:0031410|GO:0005769|GO:0031100|GO:0005773|GO:0001889|GO:0005501|GO:0016023|GO:0005770|GO:0048471|GO:0031988|GO:0016301|GO:0030118|GO:0012501|GO:0032526|GO:0031406|GO:0030140|GO:0043068|GO:0016773|GO:0004930|GO:0005634|GO:0005537|GO:0043067|GO:0005925|GO:0007283|GO:0043065|GO:0030139|GO:0000323|GO:0007167|GO:0030135|GO:0031995|GO:0042981|GO:0004672|GO:0006897|GO:0004714|GO:0005765|GO:0006915|GO:0001972|GO:0030136|GO:0005764|GO:0005010|GO:0004713|GO:0006898|GO:0007169|GO:0048009 developmental process|macromolecular complex|signal transducer activity|reproduction|transporter activity|signaling|cell|membrane|cellular process|extracellular region|reproductive process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|receptor activity|cell-substrate junction|regulation of cellular process|intracellular organelle|single organism reproductive process|ion binding|cell surface|sexual reproduction|signaling receptor activity|carbohydrate binding|membrane-bounded organelle|lipid binding|cell periphery|multicellular organism reproduction|intrinsic component of membrane|extracellular space|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|organelle membrane|multicellular organismal reproductive process|identical protein binding|phosphoprotein binding|isoprenoid binding|monosaccharide binding|post-embryonic development|growth factor binding|transport|regulation of cell death|multicellular organism development|animal organ development|anion binding|cell-substrate adherens junction|adherens junction|transferase activity, transferring phosphorus-containing groups|vesicle|membrane coat|positive regulation of cell death|integral component of plasma membrane|intracellular membrane-bounded organelle|transport vesicle|enzyme binding|transmembrane signaling receptor activity|vacuolar membrane|cytoplasm|G-protein alpha-subunit binding|nuclear envelope|organic acid binding|intrinsic component of plasma membrane|cell communication|gamete generation|signal transduction|extracellular exosome|cell death|nuclear envelope lumen|glycoprotein binding|integral component of membrane|response to organic substance|gland development|Golgi apparatus|endosome|vesicle-mediated transport|G-protein coupled receptor signaling pathway|Golgi-associated vesicle|insulin-like growth factor binding|trans-Golgi network|male gamete generation|cell surface receptor signaling pathway|response to lipid|cytoplasmic vesicle|early endosome|organ regeneration|vacuole|liver development|retinoid binding|cytoplasmic, membrane-bounded vesicle|late endosome|perinuclear region of cytoplasm|membrane-bounded vesicle|kinase activity|clathrin coat|programmed cell death|response to retinoic acid|carboxylic acid binding|trans-Golgi network transport vesicle|positive regulation of programmed cell death|phosphotransferase activity, alcohol group as acceptor|G-protein coupled receptor activity|nucleus|mannose binding|regulation of programmed cell death|focal adhesion|spermatogenesis|positive regulation of apoptotic process|endocytic vesicle|lytic vacuole|enzyme linked receptor protein signaling pathway|coated vesicle|insulin-like growth factor II binding|regulation of apoptotic process|protein kinase activity|endocytosis|transmembrane receptor protein tyrosine kinase activity|lysosomal membrane|apoptotic process|retinoic acid binding|clathrin-coated vesicle|lysosome|insulin-like growth factor-activated receptor activity|protein tyrosine kinase activity|receptor-mediated endocytosis|transmembrane receptor protein tyrosine kinase signaling pathway|insulin-like growth factor receptor signaling pathway K06564 insulin-like growth factor 2 receptor[-] hsa04144|hsa04142 Endocytosis - Homo sapiens (human)|Lysosome - Homo sapiens (human) 6:159969099-160113507 840 1067 1473 2954 3211 3216 3.75048764983351 4.32964985118606 5.92959883079263 11.8172539932973 11.7629605394453 13.4571579561885 4.66991211060407 12.3457908296437 -1.40255195033743 8.86558152241546e-11 2.34431417865537e-09 DOWN ENSG00000140941 MAP1LC3B microtubule associated protein 1 light chain 3 beta [Source:HGNC Symbol;Acc:HGNC:13352] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0009056|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0005622|GO:0005515|GO:0012505|GO:0005929|GO:0031090|GO:0019222|GO:0010506|GO:0005930|GO:0009991|GO:0005874|GO:0031982|GO:0051128|GO:0033554|GO:0022607|GO:0043231|GO:0019899|GO:0005774|GO:0005737|GO:0031668|GO:0032403|GO:0010646|GO:0007154|GO:0000422|GO:0008092|GO:0016236|GO:0031323|GO:0042594|GO:0006996|GO:0015631|GO:0005829|GO:1903008|GO:0000423|GO:0031410|GO:0007005|GO:1903146|GO:0005773|GO:0008017|GO:0000421|GO:0016241|GO:0005739|GO:0009267|GO:0070925|GO:0033043|GO:0031669|GO:0000045|GO:0031667|GO:0005856|GO:0007033|GO:0044389|GO:0031625|GO:0006995|GO:0005776|GO:0015630|GO:0010821 cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|catabolic process|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|intracellular|protein binding|endomembrane system|cilium|organelle membrane|regulation of metabolic process|regulation of autophagy|axoneme|response to extracellular stimulus|microtubule|vesicle|regulation of cellular component organization|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|vacuolar membrane|cytoplasm|cellular response to extracellular stimulus|protein complex binding|regulation of cell communication|cell communication|mitophagy|cytoskeletal protein binding|macroautophagy|regulation of cellular metabolic process|response to starvation|organelle organization|tubulin binding|cytosol|organelle disassembly|macromitophagy|cytoplasmic vesicle|mitochondrion organization|regulation of mitophagy|vacuole|microtubule binding|autophagosome membrane|regulation of macroautophagy|mitochondrion|cellular response to starvation|organelle assembly|regulation of organelle organization|cellular response to nutrient levels|autophagosome assembly|response to nutrient levels|cytoskeleton|vacuole organization|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular response to nitrogen starvation|autophagosome|microtubule cytoskeleton|regulation of mitochondrion organization - - - - 16:87383995-87404779 2116 2161 2113 919 1017 1002 20.1235784616767 18.6777375525892 18.117709005174 7.83074051360765 7.93558016973026 8.93071226741341 18.9730083398133 8.23234431691711 1.20457321989037 8.91708007836288e-11 2.35584520937562e-09 UP ENSG00000148848 ADAM12 ADAM metallopeptidase domain 12 [Source:HGNC Symbol;Acc:HGNC:190] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0009653|GO:0007155|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0006949|GO:0061061|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0019904|GO:0007154|GO:0007165|GO:0048869|GO:0016021|GO:0019538|GO:0046872|GO:0007166|GO:0042692|GO:0017124|GO:0031981|GO:0006508|GO:0005654|GO:0005739|GO:0030154|GO:0005634|GO:0008237|GO:0007520|GO:0007167|GO:0004175|GO:0051146|GO:0046914|GO:0014902|GO:0008270|GO:0004222|GO:0007169|GO:0038127|GO:0007173 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|anatomical structure morphogenesis|cell adhesion|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|syncytium formation|muscle structure development|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|protein domain specific binding|cell communication|signal transduction|cellular developmental process|integral component of membrane|protein metabolic process|metal ion binding|cell surface receptor signaling pathway|muscle cell differentiation|SH3 domain binding|nuclear lumen|proteolysis|nucleoplasm|mitochondrion|cell differentiation|nucleus|metallopeptidase activity|myoblast fusion|enzyme linked receptor protein signaling pathway|endopeptidase activity|striated muscle cell differentiation|transition metal ion binding|myotube differentiation|zinc ion binding|metalloendopeptidase activity|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 10:126012381-126388455 44 40 72 201 214 204 0.296025232225324 0.2445779040482 0.436740179480302 1.21163540095068 1.18129955668153 1.28628347527717 0.325781105251275 1.22640614430313 -1.91246199248988 8.92748518236912e-11 2.35650877660873e-09 DOWN ENSG00000102271 KLHL4 kelch like family member 4 [Source:HGNC Symbol;Acc:HGNC:6355] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0005737|GO:0008092|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0004842|GO:0031461|GO:0003779|GO:0036211|GO:1990234|GO:0044267|GO:0005856|GO:0006464|GO:0031463|GO:0032446|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|protein complex|transferase activity|cytoplasm|cytoskeletal protein binding|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|actin binding|protein modification process|transferase complex|cellular protein metabolic process|cytoskeleton|cellular protein modification process|Cul3-RING ubiquitin ligase complex|protein modification by small protein conjugation|protein ubiquitination - - - - X:87517749-87670050 1 3 2 25 32 31 0.010741756742959 0.0292793459160714 0.0193618858520685 0.240511423203528 0.281907951398636 0.311952060368984 0.0197943295036996 0.278123811657049 -3.81256816207694 9.09711545248282e-11 2.39916329256556e-09 DOWN ENSG00000113712 CSNK1A1 casein kinase 1, alpha 1 [Source:HGNC Symbol;Acc:HGNC:2451] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0005929|GO:0007049|GO:0045103|GO:0006810|GO:0022402|GO:0043168|GO:0000776|GO:0001882|GO:0016772|GO:0005882|GO:0051098|GO:0043231|GO:0005737|GO:0005849|GO:0009966|GO:0072372|GO:0010646|GO:0007154|GO:0007165|GO:0000166|GO:0051301|GO:0009967|GO:0019538|GO:0010256|GO:0006996|GO:0016192|GO:0030111|GO:0006909|GO:0005829|GO:0005813|GO:0007166|GO:0035639|GO:1903047|GO:0043412|GO:0007010|GO:0007030|GO:0005815|GO:0001883|GO:0036211|GO:0000278|GO:0032549|GO:0031981|GO:0005654|GO:0005694|GO:0016301|GO:0045095|GO:0006796|GO:0044267|GO:0007067|GO:0017076|GO:0030177|GO:0005847|GO:0016773|GO:0045104|GO:0005856|GO:0005634|GO:0000777|GO:1904424|GO:0016055|GO:0060828|GO:0000793|GO:0005524|GO:0030554|GO:0016310|GO:0016604|GO:0015630|GO:0045111|GO:0004672|GO:0006897|GO:0006464|GO:0090263|GO:0000775|GO:0016607|GO:0000779|GO:0006468|GO:0060070|GO:0018193|GO:0004674|GO:0018105 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|transferase activity|cilium|cell cycle|intermediate filament-based process|transport|cell cycle process|anion binding|kinetochore|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intermediate filament|regulation of binding|intracellular membrane-bounded organelle|cytoplasm|mRNA cleavage factor complex|regulation of signal transduction|primary cilium|regulation of cell communication|cell communication|signal transduction|nucleotide binding|cell division|positive regulation of signal transduction|protein metabolic process|endomembrane system organization|organelle organization|vesicle-mediated transport|regulation of Wnt signaling pathway|phagocytosis|cytosol|centrosome|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|Golgi organization|microtubule organizing center|purine nucleoside binding|protein modification process|mitotic cell cycle|ribonucleoside binding|nuclear lumen|nucleoplasm|chromosome|kinase activity|keratin filament|phosphate-containing compound metabolic process|cellular protein metabolic process|mitotic nuclear division|purine nucleotide binding|positive regulation of Wnt signaling pathway|mRNA cleavage and polyadenylation specificity factor complex|phosphotransferase activity, alcohol group as acceptor|intermediate filament cytoskeleton organization|cytoskeleton|nucleus|condensed chromosome kinetochore|regulation of GTP binding|Wnt signaling pathway|regulation of canonical Wnt signaling pathway|condensed chromosome|ATP binding|adenyl nucleotide binding|phosphorylation|nuclear body|microtubule cytoskeleton|intermediate filament cytoskeleton|protein kinase activity|endocytosis|cellular protein modification process|positive regulation of canonical Wnt signaling pathway|chromosome, centromeric region|nuclear speck|condensed chromosome, centromeric region|protein phosphorylation|canonical Wnt signaling pathway|peptidyl-amino acid modification|protein serine/threonine kinase activity|peptidyl-serine phosphorylation K08957 casein kinase 1, alpha[2.7.11.1] hsa04310|hsa04340 Wnt signaling pathway - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 5:149492197-149551552 1115 1494 2076 4221 4765 4291 5.18755591751301 6.31711069486723 8.70821922065134 17.5954729179595 18.1894133167181 18.7100687587636 6.73762861101053 18.1649849978137 -1.43084736217463 9.27464442795571e-11 2.44382378422056e-09 DOWN ENSG00000170006 TMEM154 transmembrane protein 154 [Source:HGNC Symbol;Acc:HGNC:26489] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 4:152618632-152680165 65 103 116 302 354 348 0.371939290159511 0.535643305193498 0.598451204219184 1.5483235969215 1.66198754234541 1.86622962127588 0.502011266524064 1.69218025351426 -1.75309160690123 9.29052933123821e-11 2.44585064069476e-09 DOWN ENSG00000082781 ITGB5 integrin subunit beta 5 [Source:HGNC Symbol;Acc:HGNC:6160] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0004872|GO:0030055|GO:0050794|GO:0019882|GO:0043229|GO:0009986|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0016032|GO:0016337|GO:0009888|GO:0019884|GO:0098797|GO:0007275|GO:0005924|GO:0043062|GO:0001618|GO:0005912|GO:0031982|GO:0022607|GO:0098609|GO:0005887|GO:0043231|GO:0005737|GO:0003012|GO:0043235|GO:0071559|GO:0031589|GO:0048598|GO:0031226|GO:0007154|GO:0001704|GO:0007165|GO:0070062|GO:0048002|GO:0048869|GO:0016021|GO:0030029|GO:0010033|GO:0006996|GO:0051701|GO:0051017|GO:0006936|GO:0007166|GO:0007010|GO:0031410|GO:0007492|GO:0009790|GO:0016023|GO:0071560|GO:0007369|GO:0007160|GO:0001706|GO:0070848|GO:0031988|GO:0002474|GO:0030036|GO:0090136|GO:0008305|GO:0019058|GO:0071310|GO:0030198|GO:0030154|GO:0005925|GO:0042590|GO:0030139|GO:0046718|GO:0035987|GO:0071363|GO:0007229|GO:0007179|GO:0007167|GO:0034684|GO:0031032|GO:0030260|GO:0030038|GO:0007015|GO:0045335|GO:0002479|GO:0043149|GO:0007178|GO:0061572 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|receptor activity|cell-substrate junction|regulation of cellular process|antigen processing and presentation|intracellular organelle|cell surface|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|viral process|single organismal cell-cell adhesion|tissue development|antigen processing and presentation of exogenous antigen|plasma membrane protein complex|multicellular organism development|cell-substrate adherens junction|extracellular structure organization|virus receptor activity|adherens junction|vesicle|cellular component assembly|cell-cell adhesion|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|muscle system process|receptor complex|response to transforming growth factor beta|cell-substrate adhesion|embryonic morphogenesis|intrinsic component of plasma membrane|cell communication|formation of primary germ layer|signal transduction|extracellular exosome|antigen processing and presentation of peptide antigen|cellular developmental process|integral component of membrane|actin filament-based process|response to organic substance|organelle organization|interaction with host|actin filament bundle assembly|muscle contraction|cell surface receptor signaling pathway|cytoskeleton organization|cytoplasmic vesicle|endoderm development|embryo development|cytoplasmic, membrane-bounded vesicle|cellular response to transforming growth factor beta stimulus|gastrulation|cell-matrix adhesion|endoderm formation|response to growth factor|membrane-bounded vesicle|antigen processing and presentation of peptide antigen via MHC class I|actin cytoskeleton organization|epithelial cell-cell adhesion|integrin complex|viral life cycle|cellular response to organic substance|extracellular matrix organization|cell differentiation|focal adhesion|antigen processing and presentation of exogenous peptide antigen via MHC class I|endocytic vesicle|viral entry into host cell|endodermal cell differentiation|cellular response to growth factor stimulus|integrin-mediated signaling pathway|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|integrin alphav-beta5 complex|actomyosin structure organization|entry into host cell|contractile actin filament bundle assembly|actin filament organization|phagocytic vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|stress fiber assembly|transmembrane receptor protein serine/threonine kinase signaling pathway|actin filament bundle organization K06588 integrin beta 5[-] hsa04151|hsa04810|hsa05205|hsa04510|hsa04145|hsa05414|hsa05410|hsa04512|hsa05412 PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 3:124761948-124901418 1554 1721 2096 4512 5108 4426 11.9444810295027 12.0220144519578 14.5251902717285 31.0729967652104 32.2132981952104 31.8828119945116 12.8305619177297 31.7230356516441 -1.30594647750977 9.30232235556916e-11 2.44679763527015e-09 DOWN ENSG00000175600 SUGCT succinyl-CoA:glutarate-CoA transferase [Source:HGNC Symbol;Acc:HGNC:16001] GO:0005623|GO:0008152|GO:0003824|GO:0043229|GO:0043227|GO:0005622|GO:0016740|GO:0043231|GO:0005737|GO:0005739|GO:0008410|GO:0047369 cell|metabolic process|catalytic activity|intracellular organelle|membrane-bounded organelle|intracellular|transferase activity|intracellular membrane-bounded organelle|cytoplasm|mitochondrion|CoA-transferase activity|succinate-hydroxymethylglutarate CoA-transferase activity - - - - 7:40134977-40860763 2 3 7 44 33 70 0.0335707465344874 0.0457741649015373 0.105935688134819 0.661768722470024 0.454502328286323 1.10122598729081 0.0617601998569479 0.739165679349052 -3.58114844534939 9.60112872719718e-11 2.52316986814916e-09 DOWN ENSG00000124784 RIOK1 RIO kinase 1 [Source:HGNC Symbol;Acc:HGNC:18656] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0043167|GO:0044237|GO:0005515|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043169|GO:0000166|GO:0019538|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|ion binding|cellular metabolic process|protein binding|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|nucleotide binding|protein metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity K07178 RIO kinase 1[2.7.11.1] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 6:7389496-7418037 1476 1716 1370 674 714 554 24.6651490575859 26.0612171193751 20.641072948611 10.091491626823 9.789568419503 8.67632566218567 23.7891463751907 9.51912856950389 1.32140209164456 9.63797734607366e-11 2.53062599551172e-09 UP ENSG00000260368 RP11-521I2.3 - - - - - - - 8:100913247-100914388 91 78 48 15 10 7 5.63664833848779 4.39090154305378 2.68063025174125 0.832469991240366 0.508230989884231 0.406366667595822 4.23606004442761 0.582355882906806 2.86275006745619 9.75834144144181e-11 2.5599782547698e-09 UP ENSG00000148158 SNX30 sorting nexin family member 30 [Source:HGNC Symbol;Acc:HGNC:23685] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0019898|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0043168|GO:0005543|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0005768|GO:0006996|GO:0016192|GO:0016050|GO:0035091|GO:0015031|GO:0006897 cell|membrane|cellular process|binding|extrinsic component of membrane|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|lipid binding|intracellular|protein binding|endomembrane system|transport|anion binding|phospholipid binding|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|endosome|organelle organization|vesicle-mediated transport|vesicle organization|phosphatidylinositol binding|protein transport|endocytosis - - - - 9:112750838-112881671 194 236 559 1216 1306 1426 1.17380667363211 1.29773358058852 3.0494423029157 6.59212111224165 6.48343622493498 8.08616198124142 1.84032751904544 7.05390643947268 -1.93845989809404 9.89715597317152e-11 2.59411496420599e-09 DOWN ENSG00000102243 VGLL1 vestigial like family member 1 [Source:HGNC Symbol;Acc:HGNC:20985] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:0008022|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003713|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|protein C-terminus binding|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:136532152-136556807 579 645 1117 2441 2539 2116 19.8145241335419 20.0606387351997 34.4645614419938 74.8463645761983 71.2911910786594 67.865634449372 24.7799081035785 71.3343967014099 -1.52542705968313 1.00489494890466e-10 2.63159068461402e-09 DOWN ENSG00000163156 SCNM1 sodium channel modifier 1 [Source:HGNC Symbol;Acc:HGNC:23136] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0006139|GO:0005730|GO:0046872|GO:0031981|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0016604|GO:0016071|GO:0016607|GO:0006397|GO:0008380 cell|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|nucleobase-containing compound metabolic process|nucleolus|metal ion binding|nuclear lumen|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|nuclear body|mRNA metabolic process|nuclear speck|mRNA processing|RNA splicing - - - - 1:151156664-151170297 834 807 757 335 393 283 11.9060561448384 10.4702207975343 9.74344107305105 4.28493405930396 4.60323429519289 3.78631543787235 10.7065726718079 4.22482793078973 1.34153223704212 1.02805138972062e-10 2.6898725844627e-09 UP ENSG00000125484 GTF3C4 general transcription factor IIIC subunit 4 [Source:HGNC Symbol;Acc:HGNC:4667] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0008047|GO:0046483|GO:0043231|GO:0016746|GO:0005667|GO:0006139|GO:0043085|GO:0050790|GO:0044249|GO:0019538|GO:0006996|GO:0051276|GO:0003677|GO:0034645|GO:0044798|GO:0043412|GO:0006325|GO:0016573|GO:0036211|GO:0031981|GO:0005654|GO:0016747|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0034660|GO:0016407|GO:0016410|GO:0016568|GO:0006464|GO:0006351|GO:0006352|GO:0006383|GO:0006399|GO:0018193|GO:0008080|GO:0000127|GO:0009303|GO:0042791|GO:0042797|GO:0006473|GO:0018205|GO:0009304|GO:0006384|GO:0018394|GO:0006475|GO:0018393|GO:0004402 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|enzyme activator activity|heterocycle metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|transcription factor complex|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|organelle organization|chromosome organization|DNA binding|cellular macromolecule biosynthetic process|nuclear transcription factor complex|macromolecule modification|chromatin organization|histone acetylation|protein modification process|nuclear lumen|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|ncRNA metabolic process|acetyltransferase activity|N-acyltransferase activity|chromatin modification|cellular protein modification process|transcription, DNA-templated|DNA-templated transcription, initiation|transcription from RNA polymerase III promoter|tRNA metabolic process|peptidyl-amino acid modification|N-acetyltransferase activity|transcription factor TFIIIC complex|rRNA transcription|5S class rRNA transcription from RNA polymerase III type 1 promoter|tRNA transcription from RNA polymerase III promoter|protein acetylation|peptidyl-lysine modification|tRNA transcription|transcription initiation from RNA polymerase III promoter|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity - - - - 9:132670035-132694955 4063 4385 3412 1681 1872 1534 30.1293445685709 29.5523865328936 22.8121438099087 11.1688427039636 11.3898163444091 10.6609809142722 27.4979583037911 11.0732133208816 1.31225056732466 1.07975705674327e-10 2.82268539159490e-09 UP ENSG00000033867 SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 [Source:HGNC Symbol;Acc:HGNC:11033] GO:0032502|GO:0005215|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0042995|GO:0022857|GO:0032420|GO:0045177|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0048856|GO:0009888|GO:0048468|GO:0016323|GO:0006810|GO:0048839|GO:0016324|GO:0007275|GO:0048513|GO:0032421|GO:0031982|GO:0005737|GO:0007423|GO:0022891|GO:0055085|GO:0048869|GO:0016021|GO:0060113|GO:0031410|GO:0043583|GO:0002064|GO:0006811|GO:0015075|GO:0060429|GO:0007399|GO:0030154|GO:0034220|GO:0048666|GO:0030182|GO:0098655|GO:0006820|GO:0015711|GO:0098656|GO:0030855|GO:0015293|GO:0002066|GO:0015297|GO:0008509|GO:0006812|GO:0008544|GO:0042491|GO:0060119|GO:0022008|GO:0008324|GO:0048699|GO:0015301|GO:0008510|GO:0035315|GO:0060117|GO:0022890|GO:0030001|GO:0008514|GO:0042490|GO:0015701|GO:0015672|GO:0009913|GO:0015106|GO:0035725|GO:0006814|GO:0060563|GO:0015077|GO:0005452|GO:0046873|GO:0015081 developmental process|transporter activity|synapse|cell|membrane|cellular process|cell projection|transmembrane transporter activity|stereocilium|apical part of cell|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|anatomical structure development|tissue development|cell development|basolateral plasma membrane|transport|inner ear development|apical plasma membrane|multicellular organism development|animal organ development|stereocilium bundle|vesicle|cytoplasm|sensory organ development|substrate-specific transmembrane transporter activity|transmembrane transport|cellular developmental process|integral component of membrane|inner ear receptor cell differentiation|cytoplasmic vesicle|ear development|epithelial cell development|ion transport|ion transmembrane transporter activity|epithelium development|nervous system development|cell differentiation|ion transmembrane transport|neuron development|neuron differentiation|cation transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|epithelial cell differentiation|symporter activity|columnar/cuboidal epithelial cell development|antiporter activity|anion transmembrane transporter activity|cation transport|epidermis development|auditory receptor cell differentiation|inner ear receptor cell development|neurogenesis|cation transmembrane transporter activity|generation of neurons|anion:anion antiporter activity|sodium:bicarbonate symporter activity|hair cell differentiation|auditory receptor cell development|inorganic cation transmembrane transporter activity|metal ion transport|organic anion transmembrane transporter activity|mechanoreceptor differentiation|bicarbonate transport|monovalent inorganic cation transport|epidermal cell differentiation|bicarbonate transmembrane transporter activity|sodium ion transmembrane transport|sodium ion transport|neuroepithelial cell differentiation|monovalent inorganic cation transmembrane transporter activity|inorganic anion exchanger activity|metal ion transmembrane transporter activity|sodium ion transmembrane transporter activity - - - - 3:27372721-27484420 106 129 183 441 436 504 0.455091586383223 0.503343796604627 0.708368727106504 1.69640849026095 1.53584853199674 2.0279300897453 0.555601370031451 1.753395704001 -1.65802955642148 1.1127904154288e-10 2.90649563098961e-09 DOWN ENSG00000160223 ICOSLG inducible T-cell co-stimulator ligand [Source:HGNC Symbol;Acc:HGNC:17087] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0008283|GO:0050794|GO:0045321|GO:0006950|GO:0006955|GO:0009628|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0002684|GO:0002682|GO:0005515|GO:0005886|GO:0008284|GO:0042127|GO:0002250|GO:0016337|GO:0070661|GO:0050867|GO:0070489|GO:0005102|GO:0006952|GO:0030155|GO:0031982|GO:0098609|GO:0002696|GO:0001775|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0070062|GO:0045785|GO:0006970|GO:0031295|GO:0016021|GO:0051249|GO:0042113|GO:0032943|GO:0034109|GO:0051251|GO:0022407|GO:0007159|GO:0006972|GO:0042110|GO:0046651|GO:0022409|GO:0042098|GO:0050863|GO:0034112|GO:0070486|GO:0050870|GO:0050671|GO:1903039|GO:0032946|GO:0050798|GO:0042129|GO:0071593|GO:0042102|GO:0046006|GO:0042104 immune system process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell proliferation|regulation of cellular process|leukocyte activation|response to stress|immune response|response to abiotic stimulus|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|positive regulation of immune system process|regulation of immune system process|protein binding|plasma membrane|positive regulation of cell proliferation|regulation of cell proliferation|adaptive immune response|single organismal cell-cell adhesion|leukocyte proliferation|positive regulation of cell activation|T cell aggregation|receptor binding|defense response|regulation of cell adhesion|vesicle|cell-cell adhesion|positive regulation of leukocyte activation|cell activation|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|extracellular exosome|positive regulation of cell adhesion|response to osmotic stress|T cell costimulation|integral component of membrane|regulation of lymphocyte activation|B cell activation|mononuclear cell proliferation|homotypic cell-cell adhesion|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|hyperosmotic response|T cell activation|lymphocyte proliferation|positive regulation of cell-cell adhesion|T cell proliferation|regulation of T cell activation|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|positive regulation of T cell activation|positive regulation of lymphocyte proliferation|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|activated T cell proliferation|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of T cell proliferation|regulation of activated T cell proliferation|positive regulation of activated T cell proliferation K06710 inducible T-cell co-stimulator ligand[-] hsa04514|hsa04672 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Intestinal immune network for IgA production - Homo sapiens (human) 21:44222991-44240966 58 56 95 237 271 278 0.319652936021836 0.280489981801939 0.472048934071168 1.17029849483673 1.22542535859247 1.43589904696291 0.357397283964981 1.27720763346404 -1.83739250478057 1.117482366269e-10 2.916199175052e-09 DOWN ENSG00000109099 PMP22 peripheral myelin protein 22 [Source:HGNC Symbol;Acc:HGNC:9118] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0043218|GO:0048523|GO:0008283|GO:0050794|GO:0043209|GO:0005911|GO:0016043|GO:0071944|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0042127|GO:0045595|GO:0048468|GO:0007275|GO:0045596|GO:0051128|GO:0022607|GO:0007267|GO:0007154|GO:0008219|GO:0008285|GO:0030030|GO:0048869|GO:0016021|GO:0043296|GO:0050768|GO:0031175|GO:0031344|GO:0010721|GO:0031345|GO:0030031|GO:0007399|GO:0030154|GO:0005923|GO:0051960|GO:0008366|GO:0007422|GO:0048666|GO:0030182|GO:0010975|GO:0032060|GO:0042552|GO:0045665|GO:0022008|GO:0050767|GO:0010977|GO:0048699|GO:0045664|GO:0007268 developmental process|signaling|cell|membrane|cellular process|cell junction|binding|compact myelin|negative regulation of cellular process|cell proliferation|regulation of cellular process|myelin sheath|cell-cell junction|cellular component organization|cell periphery|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|regulation of cell proliferation|regulation of cell differentiation|cell development|multicellular organism development|negative regulation of cell differentiation|regulation of cellular component organization|cellular component assembly|cell-cell signaling|cell communication|cell death|negative regulation of cell proliferation|cell projection organization|cellular developmental process|integral component of membrane|apical junction complex|negative regulation of neurogenesis|neuron projection development|regulation of cell projection organization|negative regulation of cell development|negative regulation of cell projection organization|cell projection assembly|nervous system development|cell differentiation|bicellular tight junction|regulation of nervous system development|axon ensheathment|peripheral nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|bleb assembly|myelination|negative regulation of neuron differentiation|neurogenesis|regulation of neurogenesis|negative regulation of neuron projection development|generation of neurons|regulation of neuron differentiation|synaptic transmission - - - - 17:15229777-15265326 183 169 178 51 66 55 2.02485085226478 1.69945009792282 1.77572755545128 0.505604146039497 0.599178104613973 0.5703330355509 1.83334283521296 0.558371762068123 1.71517870651194 1.12104639716315e-10 2.92294490313614e-09 UP ENSG00000134758 RNF138 ring finger protein 138, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:17765] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0031325|GO:0043231|GO:0043169|GO:0019899|GO:0007154|GO:0007165|GO:0019787|GO:0019538|GO:0031323|GO:0032268|GO:0045732|GO:0046872|GO:0007166|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:0051247|GO:0006508|GO:0019900|GO:0032270|GO:0044267|GO:0044390|GO:0042176|GO:0051246|GO:0005634|GO:0016055|GO:0044257|GO:0061630|GO:0010498|GO:1903364|GO:0030162|GO:0045862|GO:0051603|GO:0046914|GO:0019901|GO:0031624|GO:0006464|GO:1903052|GO:0019941|GO:1901800|GO:0061136|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0032436|GO:0016567|GO:0000209 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|ligase activity|intracellular|protein binding|transferase activity|regulation of metabolic process|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cell communication|signal transduction|ubiquitin-like protein transferase activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|positive regulation of protein metabolic process|proteolysis|kinase binding|positive regulation of cellular protein metabolic process|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein catabolic process|regulation of protein metabolic process|nucleus|Wnt signaling pathway|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|positive regulation of cellular protein catabolic process|regulation of proteolysis|positive regulation of proteolysis|proteolysis involved in cellular protein catabolic process|transition metal ion binding|protein kinase binding|ubiquitin conjugating enzyme binding|cellular protein modification process|positive regulation of proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|regulation of proteasomal protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 18:32091855-32131561 846 869 807 269 446 257 7.5779887569965 7.07430122586868 6.51735084463672 2.15890899663621 3.27783211391997 2.15747145303097 7.05654694250063 2.53140418786238 1.47902450624988 1.13912744321427e-10 2.96749656978349e-09 UP ENSG00000253854 RP11-10N23.2 - - - - - - - 8:93719574-93721167 15 18 16 77 78 104 1.12996440329811 1.23234444880005 1.08673997012504 5.19719420148686 4.82103900502211 7.34245337623802 1.14968294074107 5.78689552758233 -2.33155354901019 1.17645661383176e-10 3.06206937657657e-09 DOWN ENSG00000011243 AKAP8L A-kinase anchoring protein 8 like [Source:HGNC Symbol;Acc:HGNC:29857] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0003676|GO:0016772|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0003677|GO:0046872|GO:0003723|GO:0031981|GO:0005654|GO:0016363|GO:0016301|GO:0006796|GO:0017151|GO:0034399|GO:0005634|GO:0016310|GO:0044822 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|nucleic acid binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|DNA binding|metal ion binding|RNA binding|nuclear lumen|nucleoplasm|nuclear matrix|kinase activity|phosphate-containing compound metabolic process|DEAD/H-box RNA helicase binding|nuclear periphery|nucleus|phosphorylation|poly(A) RNA binding K15978 A-kinase anchor protein 8-like protein[-] hsa05169 Epstein-Barr virus infection - Homo sapiens (human) 19:15380048-15419141 1030 1066 1129 513 495 514 6.75683475331576 6.35540432770136 6.67750332710823 3.01523280335671 2.66427875423645 3.1600829681834 6.59658080270845 2.94653150859219 1.1627007342675 1.18439020685337e-10 3.08003355709065e-09 UP ENSG00000117010 ZNF684 zinc finger protein 684 [Source:HGNC Symbol;Acc:HGNC:28418] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 1:40531561-40548169 159 183 142 33 57 46 1.98782846692736 2.07928715184298 1.6006038158569 0.369648631797009 0.584685567088151 0.538970814974733 1.88923981154241 0.497768337953298 1.92425947111348 1.19253613406541e-10 3.09851816765786e-09 UP ENSG00000166503 RP11-382A20.3 Hepatoma-derived growth factor-related protein 3 [Source:UniProtKB/Swiss-Prot;Acc:Q9Y3E1] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0048468|GO:0007275|GO:0005102|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0032886|GO:0032403|GO:0008092|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0015631|GO:0005829|GO:0031175|GO:0007010|GO:0070507|GO:0008017|GO:0031981|GO:0043242|GO:0005654|GO:0006461|GO:0043244|GO:0033043|GO:0007399|GO:0030154|GO:0008083|GO:0000226|GO:0005634|GO:0048666|GO:0030182|GO:0043241|GO:0034622|GO:0043623|GO:0031110|GO:0051494|GO:0051493|GO:0031109|GO:1901879|GO:0022008|GO:0007019|GO:0051258|GO:0007026|GO:0048699|GO:0043624|GO:0031111|GO:0046785|GO:0051261 developmental process|cell|cellular process|binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|cell development|multicellular organism development|receptor binding|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|regulation of microtubule-based process|protein complex binding|cytoskeletal protein binding|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|tubulin binding|cytosol|neuron projection development|cytoskeleton organization|regulation of microtubule cytoskeleton organization|microtubule binding|nuclear lumen|negative regulation of protein complex disassembly|nucleoplasm|protein complex assembly|regulation of protein complex disassembly|regulation of organelle organization|nervous system development|cell differentiation|growth factor activity|microtubule cytoskeleton organization|nucleus|neuron development|neuron differentiation|protein complex disassembly|cellular macromolecular complex assembly|cellular protein complex assembly|regulation of microtubule polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|microtubule polymerization or depolymerization|regulation of protein depolymerization|neurogenesis|microtubule depolymerization|protein polymerization|negative regulation of microtubule depolymerization|generation of neurons|cellular protein complex disassembly|negative regulation of microtubule polymerization or depolymerization|microtubule polymerization|protein depolymerization - - - - 15:83112738-83208018 272 326 403 903 1135 799 1.11306587846728 1.21240659943172 1.48685954512098 3.31082692922043 3.81079150576256 3.06426814366161 1.27077734100666 3.39529552621487 -1.41782588101315 1.19898956242053e-10 3.1125769040437e-09 DOWN ENSG00000156531 PHF6 PHD finger protein 6 [Source:HGNC Symbol;Acc:HGNC:18145] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0051219|GO:0006725|GO:0042393|GO:1901360|GO:0003676|GO:0043021|GO:0034641|GO:0000776|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0097110|GO:0006139|GO:0008092|GO:0044249|GO:0031323|GO:0005730|GO:0015631|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0003723|GO:0051252|GO:0031981|GO:0042826|GO:0005654|GO:0005694|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000777|GO:0032774|GO:0000793|GO:2001141|GO:0046914|GO:0044822|GO:0006351|GO:0006355|GO:0000775|GO:0000779|GO:1903506|GO:0008270 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|phosphoprotein binding|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|nucleic acid binding|ribonucleoprotein complex binding|cellular nitrogen compound metabolic process|kinetochore|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|scaffold protein binding|nucleobase-containing compound metabolic process|cytoskeletal protein binding|cellular biosynthetic process|regulation of cellular metabolic process|nucleolus|tubulin binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|regulation of RNA metabolic process|nuclear lumen|histone deacetylase binding|nucleoplasm|chromosome|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|condensed chromosome kinetochore|RNA biosynthetic process|condensed chromosome|regulation of RNA biosynthetic process|transition metal ion binding|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|chromosome, centromeric region|condensed chromosome, centromeric region|regulation of nucleic acid-templated transcription|zinc ion binding - - - - X:134373253-134428791 997 1144 1606 3253 3574 3261 4.63672861119599 4.83529226016351 6.73404875559319 13.5549609930326 13.6376338190512 14.213344156847 5.40202320898423 13.8019796563103 -1.35330346830923 1.22762681507034e-10 3.18415038550042e-09 DOWN ENSG00000145685 LHFPL2 lipoma HMGIC fusion partner-like 2 [Source:HGNC Symbol;Acc:HGNC:6588] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 5:78485215-78770021 123 86 206 473 559 673 0.624240130491616 0.396664369263881 0.942599007716623 2.15082145578606 2.32768955191276 3.20102435517908 0.654501169157373 2.5598451209593 -1.96758885065557 1.23962210486559e-10 3.21247207627235e-09 DOWN ENSG00000196235 SUPT5H SPT5 homolog, DSIF elongation factor subunit [Source:HGNC Symbol;Acc:HGNC:11469] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0016032|GO:0007049|GO:0008023|GO:0010506|GO:0006725|GO:1901360|GO:0009991|GO:0003676|GO:0034641|GO:0048524|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0010508|GO:0046983|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0016236|GO:0044249|GO:0050792|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0003723|GO:0010629|GO:0046982|GO:0051252|GO:0006325|GO:0010628|GO:0019083|GO:0016239|GO:0016241|GO:0039692|GO:0031981|GO:0005654|GO:0006259|GO:1903902|GO:0010467|GO:0019079|GO:0019058|GO:0032044|GO:0031328|GO:0009059|GO:0016070|GO:0031667|GO:0010557|GO:0005634|GO:0043631|GO:0045893|GO:0006396|GO:0045892|GO:0050684|GO:0046782|GO:0032774|GO:2001141|GO:1902679|GO:0016071|GO:0016568|GO:0044822|GO:0050434|GO:0006351|GO:0006355|GO:0006378|GO:0045944|GO:0006366|GO:0032784|GO:1903507|GO:0032785|GO:0032786|GO:0006357|GO:1903506|GO:0031441|GO:0006354|GO:0031440|GO:0006397|GO:0006338|GO:0000122|GO:0031123|GO:0006368|GO:0006370|GO:0031124|GO:1900364|GO:0009452 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|viral process|cell cycle|transcription elongation factor complex|regulation of autophagy|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|response to extracellular stimulus|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|positive regulation of autophagy|protein dimerization activity|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|macroautophagy|cellular biosynthetic process|regulation of viral process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|chromatin organization|positive regulation of gene expression|viral transcription|positive regulation of macroautophagy|regulation of macroautophagy|single stranded viral RNA replication via double stranded DNA intermediate|nuclear lumen|nucleoplasm|DNA metabolic process|positive regulation of viral life cycle|gene expression|viral genome replication|viral life cycle|DSIF complex|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|response to nutrient levels|positive regulation of macromolecule biosynthetic process|nucleus|RNA polyadenylation|positive regulation of transcription, DNA-templated|RNA processing|negative regulation of transcription, DNA-templated|regulation of mRNA processing|regulation of viral transcription|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|mRNA metabolic process|chromatin modification|poly(A) RNA binding|positive regulation of viral transcription|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA polyadenylation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|negative regulation of nucleic acid-templated transcription|negative regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of mRNA 3'-end processing|DNA-templated transcription, elongation|regulation of mRNA 3'-end processing|mRNA processing|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|RNA 3'-end processing|transcription elongation from RNA polymerase II promoter|7-methylguanosine mRNA capping|mRNA 3'-end processing|negative regulation of mRNA polyadenylation|7-methylguanosine RNA capping - - - - 19:39436156-39476670 5872 5936 5183 2532 2703 2335 35.7212615951757 32.8181898809668 28.4273362861636 13.8007338210091 13.4913306492086 13.3124078156246 32.3222625874354 13.5348240952808 1.25585205381933 1.24873082539837e-10 3.23327060376783e-09 UP ENSG00000104447 TRPS1 trichorhinophalangeal syndrome I [Source:HGNC Symbol;Acc:HGNC:12340] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0048565|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0043169|GO:0000981|GO:0009887|GO:0005667|GO:0045184|GO:0009890|GO:0003682|GO:0006139|GO:0008104|GO:0051649|GO:0008134|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0051216|GO:0055123|GO:0046872|GO:0043412|GO:0072594|GO:0072358|GO:0001085|GO:0010629|GO:0031056|GO:0051252|GO:0006325|GO:0015031|GO:0010628|GO:0036211|GO:0046907|GO:0032330|GO:0031981|GO:0005654|GO:0034613|GO:0033043|GO:0044267|GO:0010467|GO:0017038|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0001228|GO:0061035|GO:0016070|GO:0072359|GO:0010557|GO:0016575|GO:0005634|GO:0006606|GO:0045165|GO:0031063|GO:0000975|GO:0045893|GO:0033365|GO:0051169|GO:0045892|GO:0002062|GO:0032774|GO:0043565|GO:0006607|GO:2001141|GO:0006605|GO:0033044|GO:1902679|GO:0003690|GO:0006886|GO:0046914|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006913|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0090311|GO:0000122|GO:0008270|GO:0034504|GO:0051170|GO:0000976|GO:0001012|GO:0006476|GO:0000977 developmental process|macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|digestive tract development|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|transport|tube development|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|organ morphogenesis|transcription factor complex|establishment of protein localization|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|protein localization|establishment of localization in cell|transcription factor binding|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|digestive system development|metal ion binding|macromolecule modification|establishment of protein localization to organelle|cardiovascular system development|RNA polymerase II transcription factor binding|negative regulation of gene expression|regulation of histone modification|regulation of RNA metabolic process|chromatin organization|protein transport|positive regulation of gene expression|protein modification process|intracellular transport|regulation of chondrocyte differentiation|nuclear lumen|nucleoplasm|cellular protein localization|regulation of organelle organization|cellular protein metabolic process|gene expression|protein import|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of cartilage development|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|protein import into nucleus|cell fate commitment|regulation of histone deacetylation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|protein localization to organelle|nuclear transport|negative regulation of transcription, DNA-templated|chondrocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|NLS-bearing protein import into nucleus|regulation of RNA biosynthetic process|protein targeting|regulation of chromosome organization|negative regulation of RNA biosynthetic process|double-stranded DNA binding|intracellular protein transport|transition metal ion binding|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of protein deacetylation|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|protein localization to nucleus|nuclear import|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|protein deacetylation|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 8:115408496-115809673 34 32 65 156 246 202 0.122240084479563 0.104558763228982 0.210697497192161 0.502520580208691 0.725661658082022 0.680630900549362 0.145832114966902 0.636271046280025 -2.12533300961888 1.27122146153894e-10 3.288652124158e-09 DOWN ENSG00000150938 CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) [Source:HGNC Symbol;Acc:HGNC:2359] GO:0032502|GO:0040007|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0016049|GO:0071704|GO:0044237|GO:0038023|GO:0016043|GO:0043227|GO:0071944|GO:0040008|GO:0031224|GO:0030234|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0004857|GO:0019838|GO:0007275|GO:0016772|GO:0031982|GO:0051128|GO:0004888|GO:0019904|GO:0007154|GO:0044092|GO:0007165|GO:0070062|GO:0050790|GO:0043086|GO:0016021|GO:0019538|GO:0001558|GO:0031324|GO:0031323|GO:0032268|GO:0005520|GO:0007166|GO:0030414|GO:0030165|GO:0032269|GO:0051346|GO:0006508|GO:0016301|GO:0044267|GO:0007399|GO:0051246|GO:0016773|GO:0004866|GO:0010466|GO:0030162|GO:0052547|GO:0007167|GO:0045861|GO:0004672|GO:0004714|GO:0005010|GO:0004713|GO:0010951|GO:0004867|GO:0007169|GO:0052548|GO:0048009 developmental process|growth|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|cell growth|organic substance metabolic process|cellular metabolic process|signaling receptor activity|cellular component organization|membrane-bounded organelle|cell periphery|regulation of growth|intrinsic component of membrane|enzyme regulator activity|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|enzyme inhibitor activity|growth factor binding|multicellular organism development|transferase activity, transferring phosphorus-containing groups|vesicle|regulation of cellular component organization|transmembrane signaling receptor activity|protein domain specific binding|cell communication|negative regulation of molecular function|signal transduction|extracellular exosome|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|protein metabolic process|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|insulin-like growth factor binding|cell surface receptor signaling pathway|peptidase inhibitor activity|PDZ domain binding|negative regulation of cellular protein metabolic process|negative regulation of hydrolase activity|proteolysis|kinase activity|cellular protein metabolic process|nervous system development|regulation of protein metabolic process|phosphotransferase activity, alcohol group as acceptor|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of proteolysis|regulation of peptidase activity|enzyme linked receptor protein signaling pathway|negative regulation of proteolysis|protein kinase activity|transmembrane receptor protein tyrosine kinase activity|insulin-like growth factor-activated receptor activity|protein tyrosine kinase activity|negative regulation of endopeptidase activity|serine-type endopeptidase inhibitor activity|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|insulin-like growth factor receptor signaling pathway - - - - 2:36355926-36551135 342 375 775 1517 1806 1760 2.98556151603156 2.97516582800308 6.09980114828521 11.8654221195681 12.9355686148984 14.3993063493604 4.02017616410662 13.066765694609 -1.70057146049208 1.28410724672715e-10 3.31911149296903e-09 DOWN ENSG00000107957 SH3PXD2A SH3 and PX domains 2A [Source:HGNC Symbol;Acc:HGNC:23664] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0042995|GO:0043229|GO:0043167|GO:0044237|GO:0009653|GO:0008289|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0006949|GO:0007275|GO:0048513|GO:0043168|GO:0005543|GO:0005737|GO:0072593|GO:0048869|GO:0002102|GO:0030097|GO:0035091|GO:0030154|GO:0005856|GO:0006801|GO:0002521|GO:0015629|GO:0072675|GO:0030099|GO:0002573|GO:0030316|GO:0072674 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|cell junction|binding|cell projection|intracellular organelle|ion binding|cellular metabolic process|anatomical structure morphogenesis|lipid binding|intracellular|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|syncytium formation|multicellular organism development|animal organ development|anion binding|phospholipid binding|cytoplasm|reactive oxygen species metabolic process|cellular developmental process|podosome|hemopoiesis|phosphatidylinositol binding|cell differentiation|cytoskeleton|superoxide metabolic process|leukocyte differentiation|actin cytoskeleton|osteoclast fusion|myeloid cell differentiation|myeloid leukocyte differentiation|osteoclast differentiation|multinuclear osteoclast differentiation - - - - 10:103594027-103855543 686 878 982 2155 2341 3577 1.72940864088898 2.01162949765632 2.23202698243996 4.86764150239023 4.8422029058019 8.45125875065994 1.99102170699509 6.05370105295069 -1.60430848295862 1.29790948015017e-10 3.35052139710007e-09 DOWN ENSG00000173715 C11orf80 chromosome 11 open reading frame 80 [Source:HGNC Symbol;Acc:HGNC:26197] - - - - - - 11:66744451-66843328 195 173 304 615 737 874 1.79045615964521 1.44363105975297 2.51661394342822 5.05943794520462 5.55219576073559 7.52089884286306 1.9169003876088 6.04417751626776 -1.65677066397825 1.29850380399437e-10 3.35052139710007e-09 DOWN ENSG00000172661 FAM21C family with sequence similarity 21 member C [Source:HGNC Symbol;Acc:HGNC:23414] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0044089|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0030904|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0045595|GO:0048468|GO:0006810|GO:0051130|GO:0034446|GO:0032535|GO:0043168|GO:0030155|GO:0005543|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0032970|GO:0031589|GO:0045184|GO:0071203|GO:0008104|GO:0051649|GO:0010008|GO:0048869|GO:0030029|GO:0031334|GO:0043254|GO:0005768|GO:0006996|GO:0016192|GO:0005730|GO:0000902|GO:0031333|GO:0032956|GO:0007010|GO:0005769|GO:0035091|GO:0015031|GO:0000904|GO:0046907|GO:2000813|GO:0031981|GO:0043242|GO:0010810|GO:0022604|GO:0006461|GO:0031901|GO:0043244|GO:0030036|GO:0032273|GO:0033043|GO:1900024|GO:0030154|GO:0030832|GO:0043243|GO:0005634|GO:0010638|GO:0043241|GO:0034622|GO:0030838|GO:0010769|GO:0042147|GO:1901881|GO:0043623|GO:0008064|GO:0016482|GO:1990126|GO:0051494|GO:0051493|GO:0032272|GO:0016197|GO:1901981|GO:1901879|GO:0007015|GO:0051495|GO:0030833|GO:0030836|GO:0051258|GO:2000812|GO:1902936|GO:0043624|GO:0070273|GO:0030837|GO:0032266|GO:0030834|GO:0005547|GO:0010314|GO:0008154|GO:0030835|GO:0080025|GO:0051693|GO:0030042|GO:0030041|GO:0005546|GO:0051261|GO:0043325|GO:0051016 developmental process|macromolecular complex|cell|membrane|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|retromer complex|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of cell differentiation|cell development|transport|positive regulation of cellular component organization|substrate adhesion-dependent cell spreading|regulation of cellular component size|anion binding|regulation of cell adhesion|phospholipid binding|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|regulation of actin filament-based process|cell-substrate adhesion|establishment of protein localization|WASH complex|protein localization|establishment of localization in cell|endosome membrane|cellular developmental process|actin filament-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|endosome|organelle organization|vesicle-mediated transport|nucleolus|cell morphogenesis|negative regulation of protein complex assembly|regulation of actin cytoskeleton organization|cytoskeleton organization|early endosome|phosphatidylinositol binding|protein transport|cell morphogenesis involved in differentiation|intracellular transport|negative regulation of barbed-end actin filament capping|nuclear lumen|negative regulation of protein complex disassembly|regulation of cell-substrate adhesion|regulation of cell morphogenesis|protein complex assembly|early endosome membrane|regulation of protein complex disassembly|actin cytoskeleton organization|positive regulation of protein polymerization|regulation of organelle organization|regulation of substrate adhesion-dependent cell spreading|cell differentiation|regulation of actin filament length|positive regulation of protein complex disassembly|nucleus|positive regulation of organelle organization|protein complex disassembly|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|regulation of cell morphogenesis involved in differentiation|retrograde transport, endosome to Golgi|positive regulation of protein depolymerization|cellular protein complex assembly|regulation of actin polymerization or depolymerization|cytosolic transport|retrograde transport, endosome to plasma membrane|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|endosomal transport|phosphatidylinositol phosphate binding|regulation of protein depolymerization|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|positive regulation of actin filament depolymerization|protein polymerization|regulation of barbed-end actin filament capping|phosphatidylinositol bisphosphate binding|cellular protein complex disassembly|phosphatidylinositol-4-phosphate binding|negative regulation of actin filament polymerization|phosphatidylinositol-3-phosphate binding|regulation of actin filament depolymerization|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-5-phosphate binding|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|phosphatidylinositol-3,5-bisphosphate binding|actin filament capping|actin filament depolymerization|actin filament polymerization|phosphatidylinositol-4,5-bisphosphate binding|protein depolymerization|phosphatidylinositol-3,4-bisphosphate binding|barbed-end actin filament capping K18462 WASH complex subunit FAM21[-] hsa04144 Endocytosis - Homo sapiens (human) 10:45727200-45792961 375 438 464 1117 1147 1053 3.2736408654963 3.47499681105124 3.65200729930029 8.73676513993369 8.21544514026043 8.61503566084006 3.46688165861594 8.52241531367806 -1.29762376728682 1.30091467387211e-10 3.35384340878912e-09 DOWN ENSG00000111670 GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits [Source:HGNC Symbol;Acc:HGNC:29670] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0044262|GO:0006810|GO:0032940|GO:0016772|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0045184|GO:0008104|GO:0051649|GO:0008134|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006996|GO:0009311|GO:0034645|GO:0046872|GO:0043412|GO:0072594|GO:0006487|GO:0015031|GO:0009100|GO:0036211|GO:0016780|GO:0046907|GO:0009306|GO:0070085|GO:0034613|GO:0006796|GO:1901137|GO:0044267|GO:0046903|GO:0000139|GO:0046835|GO:0009059|GO:0005634|GO:0007033|GO:0006623|GO:0009101|GO:0043413|GO:0033365|GO:0003976|GO:0006491|GO:0016310|GO:0006605|GO:0005509|GO:0006886|GO:0006622|GO:0072666|GO:0006464|GO:0007034|GO:0007041|GO:0016256|GO:0007040|GO:0061462 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|protein glycosylation|cellular carbohydrate metabolic process|transport|secretion by cell|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|establishment of protein localization|protein localization|establishment of localization in cell|transcription factor binding|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|organelle organization|oligosaccharide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|establishment of protein localization to organelle|protein N-linked glycosylation|protein transport|glycoprotein metabolic process|protein modification process|phosphotransferase activity, for other substituted phosphate groups|intracellular transport|protein secretion|glycosylation|cellular protein localization|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|secretion|Golgi membrane|carbohydrate phosphorylation|macromolecule biosynthetic process|nucleus|vacuole organization|protein targeting to vacuole|glycoprotein biosynthetic process|macromolecule glycosylation|protein localization to organelle|UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity|N-glycan processing|phosphorylation|protein targeting|calcium ion binding|intracellular protein transport|protein targeting to lysosome|establishment of protein localization to vacuole|cellular protein modification process|vacuolar transport|lysosomal transport|N-glycan processing to lysosome|lysosome organization|protein localization to lysosome K08239 UDP-N-acetylglucosamine-lysosomal-enzyme[2.7.8.17] hsa04142 Lysosome - Homo sapiens (human) 12:101745497-101830938 230 256 370 790 839 782 1.367065654022 1.38287113118576 1.9827979584573 4.20714280193986 4.09158961557498 4.356099523268 1.57757824788835 4.21827731359428 -1.4189423777411 1.32801930138316e-10 3.42076688727289e-09 DOWN ENSG00000129437 KLK14 kallikrein related peptidase 14 [Source:HGNC Symbol;Acc:HGNC:6362] GO:0032502|GO:0000003|GO:0023052|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0003824|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0044702|GO:0071704|GO:0019953|GO:0023051|GO:0009653|GO:0043227|GO:0023057|GO:0032504|GO:0016787|GO:0005615|GO:0048856|GO:0048609|GO:0007618|GO:0009888|GO:0031982|GO:0008233|GO:0070684|GO:0009966|GO:0048729|GO:0010646|GO:0007320|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0009566|GO:0009967|GO:0019538|GO:0017171|GO:0007186|GO:0002009|GO:0008277|GO:0045744|GO:0006508|GO:0007620|GO:0060429|GO:0008236|GO:0045745|GO:0004252|GO:0008544|GO:0004175|GO:0048730 developmental process|reproduction|signaling|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|single organism reproductive process|organic substance metabolic process|sexual reproduction|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|negative regulation of signaling|multicellular organism reproduction|hydrolase activity|extracellular space|anatomical structure development|multicellular organismal reproductive process|mating|tissue development|vesicle|peptidase activity|seminal clot liquefaction|regulation of signal transduction|tissue morphogenesis|regulation of cell communication|insemination|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|fertilization|positive regulation of signal transduction|protein metabolic process|serine hydrolase activity|G-protein coupled receptor signaling pathway|morphogenesis of an epithelium|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of G-protein coupled receptor protein signaling pathway|proteolysis|copulation|epithelium development|serine-type peptidase activity|positive regulation of G-protein coupled receptor protein signaling pathway|serine-type endopeptidase activity|epidermis development|endopeptidase activity|epidermis morphogenesis - - - - 19:51077495-51084245 61 73 50 12 11 13 3.26151115129192 3.54724374635672 2.41030676604833 0.574883016842038 0.482543383736365 0.651440456093075 3.07302055456566 0.569622285557159 2.43157992109465 1.3657658161722e-10 3.51496316172457e-09 UP ENSG00000184492 FOXD4L1 forkhead box D4-like 1 [Source:HGNC Symbol;Acc:HGNC:18521] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 2:113498665-113501155 126 98 42 14 8 7 3.57801144004905 2.5291672435764 1.07531571076204 0.356215149135161 0.186403635739871 0.186298970049951 2.39416479812916 0.242972584974994 3.30065701477651 1.38280877236286e-10 3.55575995608277e-09 UP ENSG00000237424 FOXD2-AS1 FOXD2 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:44256] - - - - - - 1:47432133-47434641 445 414 577 180 195 103 12.5460049355455 10.6078134356519 14.6667868278097 4.5468986687756 4.51074020950113 2.72151374049812 12.606868399669 3.92638420625828 1.68293669246835 1.3899250458031e-10 3.57098298772854e-09 UP ENSG00000103528 SYT17 synaptotagmin 17 [Source:HGNC Symbol;Acc:HGNC:24119] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0016049|GO:0043167|GO:0009653|GO:0016043|GO:0045927|GO:0043227|GO:0008289|GO:0040008|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0045595|GO:0048468|GO:0006810|GO:0051130|GO:0007275|GO:0043168|GO:0030307|GO:0032940|GO:0005543|GO:0031982|GO:0051128|GO:0030276|GO:0045597|GO:0043231|GO:0043169|GO:0030133|GO:0005737|GO:0048639|GO:0000149|GO:0048588|GO:0048638|GO:0030030|GO:0048869|GO:0001558|GO:0005794|GO:0060560|GO:0016192|GO:0000902|GO:0031175|GO:0031344|GO:0005802|GO:0046872|GO:0031410|GO:0010720|GO:0031346|GO:0016023|GO:0006887|GO:0070382|GO:0050769|GO:0031988|GO:0022604|GO:0005544|GO:0032990|GO:0007399|GO:0046903|GO:0030154|GO:0048858|GO:1903861|GO:0019905|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0005509|GO:0097484|GO:0022008|GO:0050767|GO:0048812|GO:0010976|GO:0045666|GO:0048699|GO:0045664 developmental process|growth|cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|cell growth|ion binding|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|membrane-bounded organelle|lipid binding|regulation of growth|regulation of developmental process|developmental growth|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of cell differentiation|cell development|transport|positive regulation of cellular component organization|multicellular organism development|anion binding|positive regulation of cell growth|secretion by cell|phospholipid binding|vesicle|regulation of cellular component organization|clathrin binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|transport vesicle|cytoplasm|positive regulation of developmental growth|SNARE binding|developmental cell growth|regulation of developmental growth|cell projection organization|cellular developmental process|regulation of cell growth|Golgi apparatus|developmental growth involved in morphogenesis|vesicle-mediated transport|cell morphogenesis|neuron projection development|regulation of cell projection organization|trans-Golgi network|metal ion binding|cytoplasmic vesicle|positive regulation of cell development|positive regulation of cell projection organization|cytoplasmic, membrane-bounded vesicle|exocytosis|exocytic vesicle|positive regulation of neurogenesis|membrane-bounded vesicle|regulation of cell morphogenesis|calcium-dependent phospholipid binding|cell part morphogenesis|nervous system development|secretion|cell differentiation|cell projection morphogenesis|positive regulation of dendrite extension|syntaxin binding|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|calcium ion binding|dendrite extension|neurogenesis|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|positive regulation of neuron differentiation|generation of neurons|regulation of neuron differentiation - - - - 16:19167971-19268334 78 89 124 351 298 455 0.519439178474154 0.538655649566471 0.744518753768712 2.09432704816047 1.62826231288586 2.83974976947688 0.600871193936446 2.18744637684107 -1.86411998596206 1.39955860684591e-10 3.59264167229387e-09 DOWN ENSG00000198786 MT-ND5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 [Source:HGNC Symbol;Acc:HGNC:7461] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0042995|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0070469|GO:0043227|GO:0031224|GO:0005622|GO:0043234|GO:0031090|GO:0006725|GO:0019866|GO:1901360|GO:0005746|GO:0034641|GO:0015980|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0010243|GO:0005737|GO:0043005|GO:0031966|GO:0006979|GO:0006139|GO:0016651|GO:0055086|GO:0045271|GO:0001666|GO:0006091|GO:0016021|GO:0022900|GO:0010035|GO:0010033|GO:0055114|GO:0005740|GO:0042542|GO:0019693|GO:0005747|GO:0009116|GO:0022904|GO:0005743|GO:0005739|GO:0016655|GO:0000302|GO:0006796|GO:0006119|GO:0045333|GO:0003954|GO:0009259|GO:0009117|GO:0042773|GO:0016310|GO:0006163|GO:0006120|GO:0042278|GO:0042775|GO:0008137|GO:0046034 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cell projection|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|respiratory chain|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein complex|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|organic cyclic compound metabolic process|mitochondrial respiratory chain|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|neuron projection|mitochondrial membrane|response to oxidative stress|nucleobase-containing compound metabolic process|oxidoreductase activity, acting on NAD(P)H|nucleobase-containing small molecule metabolic process|respiratory chain complex I|response to hypoxia|generation of precursor metabolites and energy|integral component of membrane|electron transport chain|response to inorganic substance|response to organic substance|oxidation-reduction process|mitochondrial envelope|response to hydrogen peroxide|ribose phosphate metabolic process|mitochondrial respiratory chain complex I|nucleoside metabolic process|respiratory electron transport chain|mitochondrial inner membrane|mitochondrion|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|response to reactive oxygen species|phosphate-containing compound metabolic process|oxidative phosphorylation|cellular respiration|NADH dehydrogenase activity|ribonucleotide metabolic process|nucleotide metabolic process|ATP synthesis coupled electron transport|phosphorylation|purine nucleotide metabolic process|mitochondrial electron transport, NADH to ubiquinone|purine nucleoside metabolic process|mitochondrial ATP synthesis coupled electron transport|NADH dehydrogenase (ubiquinone) activity|ATP metabolic process K03883 NADH-ubiquinone oxidoreductase chain 5[1.6.5.3] hsa01100|hsa05012|hsa00190 Metabolic pathways - Homo sapiens (human)|Parkinson,s disease - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human) MT:12337-14148 33644 0 26365 0 0 0 1313.39443370512 0 927.960625880701 0 0 0 747.118353195274 0 Inf 1.45110860296887e-10 3.72176943582755e-09 UP ENSG00000106003 LFNG LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [Source:HGNC Symbol;Acc:HGNC:6560] GO:0032502|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0044702|GO:0051321|GO:0043167|GO:0006955|GO:0042698|GO:0003006|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0023057|GO:0032504|GO:0031224|GO:0050793|GO:0005622|GO:0002520|GO:0022602|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0031090|GO:0048609|GO:0045137|GO:0007049|GO:0016337|GO:0001756|GO:0031228|GO:0009888|GO:0022402|GO:0002313|GO:0007275|GO:0048513|GO:0070489|GO:0031982|GO:0098609|GO:0051098|GO:0043231|GO:0048608|GO:0001541|GO:0043169|GO:0005737|GO:0007389|GO:0045992|GO:0009887|GO:0001775|GO:0002312|GO:0009966|GO:0002263|GO:0007548|GO:0010646|GO:0046649|GO:0008406|GO:0007154|GO:0007165|GO:0007126|GO:0002366|GO:0009968|GO:0016757|GO:0048869|GO:0016021|GO:0009967|GO:0031301|GO:0005794|GO:0006996|GO:0042113|GO:0046872|GO:0007166|GO:0008585|GO:0061458|GO:0030097|GO:0030098|GO:0008194|GO:0009790|GO:0046545|GO:0030173|GO:1902367|GO:0002315|GO:0003002|GO:0016758|GO:0045747|GO:0007159|GO:0051099|GO:0008593|GO:0007143|GO:0014807|GO:0042110|GO:0060429|GO:0000139|GO:0030154|GO:0045746|GO:0045995|GO:0043393|GO:0002521|GO:0009792|GO:0030183|GO:0008375|GO:0030217|GO:0070486|GO:0061053|GO:0032092|GO:0009952|GO:0007219|GO:0035282|GO:0033829|GO:0007386|GO:0002335|GO:0043009|GO:0071593 developmental process|reproduction|immune system process|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|single organism reproductive process|meiotic cell cycle|ion binding|immune response|ovulation cycle|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|negative regulation of signaling|multicellular organism reproduction|intrinsic component of membrane|regulation of developmental process|intracellular|immune system development|ovulation cycle process|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|multicellular organismal reproductive process|development of primary sexual characteristics|cell cycle|single organismal cell-cell adhesion|somitogenesis|intrinsic component of Golgi membrane|tissue development|cell cycle process|mature B cell differentiation involved in immune response|multicellular organism development|animal organ development|T cell aggregation|vesicle|cell-cell adhesion|regulation of binding|intracellular membrane-bounded organelle|reproductive structure development|ovarian follicle development|cation binding|cytoplasm|pattern specification process|negative regulation of embryonic development|organ morphogenesis|cell activation|B cell activation involved in immune response|regulation of signal transduction|cell activation involved in immune response|sex differentiation|regulation of cell communication|lymphocyte activation|gonad development|cell communication|signal transduction|meiotic nuclear division|leukocyte activation involved in immune response|negative regulation of signal transduction|transferase activity, transferring glycosyl groups|cellular developmental process|integral component of membrane|positive regulation of signal transduction|integral component of organelle membrane|Golgi apparatus|organelle organization|B cell activation|metal ion binding|cell surface receptor signaling pathway|female gonad development|reproductive system development|hemopoiesis|lymphocyte differentiation|UDP-glycosyltransferase activity|embryo development|development of primary female sexual characteristics|integral component of Golgi membrane|negative regulation of Notch signaling pathway involved in somitogenesis|marginal zone B cell differentiation|regionalization|transferase activity, transferring hexosyl groups|positive regulation of Notch signaling pathway|leukocyte cell-cell adhesion|positive regulation of binding|regulation of Notch signaling pathway|female meiotic division|regulation of somitogenesis|T cell activation|epithelium development|Golgi membrane|cell differentiation|negative regulation of Notch signaling pathway|regulation of embryonic development|regulation of protein binding|leukocyte differentiation|embryo development ending in birth or egg hatching|B cell differentiation|acetylglucosaminyltransferase activity|T cell differentiation|leukocyte aggregation|somite development|positive regulation of protein binding|anterior/posterior pattern specification|Notch signaling pathway|segmentation|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|compartment pattern specification|mature B cell differentiation|chordate embryonic development|lymphocyte aggregation K05948 fringe[2.4.1.222] hsa04330|hsa00514 Notch signaling pathway - Homo sapiens (human)|Other types of O-glycan biosynthesis - Homo sapiens (human) 7:2512529-2529177 62 68 88 269 238 262 0.795083336771742 0.7925193149704 1.01746466261844 3.09080934489415 2.50418086768233 3.14884904064985 0.868355771453527 2.91461308440878 -1.74694622683782 1.46839290003889e-10 3.76286709337003e-09 DOWN ENSG00000136052 SLC41A2 solute carrier family 41 (magnesium transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:31045] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0022857|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0006810|GO:0022891|GO:0055085|GO:0016021|GO:0006811|GO:0015075|GO:0034220|GO:0098655|GO:0006812|GO:0008324 transporter activity|cell|membrane|cellular process|binding|transmembrane transporter activity|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|transport|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|ion transport|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|cation transport|cation transmembrane transporter activity - - - - 12:104802553-104958744 4 9 30 105 118 134 0.0312289461139802 0.0638649164866993 0.211178235270162 0.734521535317383 0.755904709288962 0.980509729428328 0.102090699290281 0.823645324678224 -3.01217178355155 1.47014378382862e-10 3.76412285784046e-09 DOWN ENSG00000273448 RP11-166O4.6 - - - - - - - 7:67333047-67334383 0 0 0 17 24 11 0 0 0 0.805865695744329 1.04183713428207 0.545410408306134 0 0.797704412777511 -Inf 1.47476492699277e-10 3.7727191200036e-09 DOWN ENSG00000121864 ZNF639 zinc finger protein 639 [Source:HGNC Symbol;Acc:HGNC:30950] GO:0040011|GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0016032|GO:0006725|GO:1901360|GO:0051702|GO:0003676|GO:0034641|GO:0030307|GO:0048524|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0043169|GO:0000981|GO:0009890|GO:0006139|GO:0043621|GO:0048525|GO:0044249|GO:0050792|GO:0001558|GO:0031324|GO:0031323|GO:0051701|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0010628|GO:0019083|GO:0031981|GO:0005654|GO:1903902|GO:0010467|GO:0019058|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0045892|GO:0046718|GO:0046782|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:1902679|GO:0003690|GO:0032897|GO:0050434|GO:0030260|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:0043923|GO:1903506|GO:0044212|GO:0043922|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 locomotion|growth|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|interaction with symbiont|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cell growth|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|protein self-association|negative regulation of viral process|cellular biosynthetic process|regulation of viral process|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|interaction with host|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|viral transcription|nuclear lumen|nucleoplasm|positive regulation of viral life cycle|gene expression|viral life cycle|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|viral entry into host cell|regulation of viral transcription|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of RNA biosynthetic process|double-stranded DNA binding|negative regulation of viral transcription|positive regulation of viral transcription|entry into host cell|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|positive regulation by host of viral transcription|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation by host of viral transcription|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 3:179322991-179338583 1127 1307 805 399 450 403 6.1707874390623 6.50387762917543 3.97399413766209 1.95743436754117 2.02160978955535 2.06800373026083 5.54955306863327 2.01568262911912 1.46110308598427 1.48236462993998e-10 3.78891384094419e-09 UP ENSG00000166068 SPRED1 sprouty-related, EVH1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20249] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0030234|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0004857|GO:0006935|GO:0045087|GO:0048468|GO:2001022|GO:0044853|GO:0007275|GO:0005102|GO:0006952|GO:0031325|GO:0033554|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0009725|GO:0050790|GO:0030030|GO:0019207|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0005901|GO:0032268|GO:0000902|GO:0031175|GO:0019210|GO:0005126|GO:0007166|GO:0043412|GO:0019887|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0032269|GO:0043517|GO:0019902|GO:0031981|GO:2001020|GO:0043434|GO:0044344|GO:0051247|GO:0051346|GO:0070848|GO:0005654|GO:0002764|GO:0019900|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:1902532|GO:0051246|GO:0030154|GO:0048858|GO:0045121|GO:1902531|GO:0032870|GO:0005634|GO:0006974|GO:0048666|GO:0030182|GO:0007411|GO:0010923|GO:0016311|GO:0031401|GO:0008543|GO:1901798|GO:0005173|GO:1901653|GO:0043408|GO:0072331|GO:0042770|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0007167|GO:0071375|GO:0043410|GO:0004860|GO:1901796|GO:0043409|GO:0033673|GO:0032868|GO:0019901|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0043516|GO:0010921|GO:0033674|GO:0048011|GO:0006470|GO:0030291|GO:0035304|GO:0000186|GO:0007265|GO:0045859|GO:0045860|GO:0006469|GO:0007409|GO:0006468|GO:0043407|GO:0048699|GO:0090311|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0018193|GO:0042326|GO:0038093|GO:0001934|GO:0035305|GO:0001933|GO:0042327|GO:0035303|GO:0030330|GO:0035308|GO:0007169|GO:0048010|GO:0038095|GO:0071901|GO:0000188|GO:0006476|GO:0010801|GO:0071900|GO:0018107|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|enzyme inhibitor activity|chemotaxis|innate immune response|cell development|positive regulation of response to DNA damage stimulus|plasma membrane raft|multicellular organism development|receptor binding|defense response|positive regulation of cellular metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|response to hormone|regulation of catalytic activity|cell projection organization|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|caveola|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|kinase inhibitor activity|cytokine receptor binding|cell surface receptor signaling pathway|macromolecule modification|protein kinase regulator activity|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|positive regulation of DNA damage response, signal transduction by p53 class mediator|phosphatase binding|nuclear lumen|regulation of response to DNA damage stimulus|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|nucleoplasm|immune response-regulating signaling pathway|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|membrane raft|regulation of intracellular signal transduction|cellular response to hormone stimulus|nucleus|cellular response to DNA damage stimulus|neuron development|neuron differentiation|axon guidance|negative regulation of phosphatase activity|dephosphorylation|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|positive regulation of signal transduction by p53 class mediator|stem cell factor receptor binding|cellular response to peptide|regulation of MAPK cascade|signal transduction by p53 class mediator|signal transduction in response to DNA damage|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|protein kinase inhibitor activity|regulation of signal transduction by p53 class mediator|negative regulation of MAPK cascade|negative regulation of kinase activity|response to insulin|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|regulation of DNA damage response, signal transduction by p53 class mediator|regulation of phosphatase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|protein dephosphorylation|protein serine/threonine kinase inhibitor activity|regulation of protein dephosphorylation|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|negative regulation of protein kinase activity|axonogenesis|protein phosphorylation|negative regulation of MAP kinase activity|generation of neurons|regulation of protein deacetylation|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|negative regulation of phosphorylation|Fc receptor signaling pathway|positive regulation of protein phosphorylation|negative regulation of dephosphorylation|negative regulation of protein phosphorylation|positive regulation of phosphorylation|regulation of dephosphorylation|DNA damage response, signal transduction by p53 class mediator|negative regulation of protein dephosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|inactivation of MAPK activity|protein deacetylation|negative regulation of peptidyl-threonine phosphorylation|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 15:38252326-38357249 284 362 420 882 1172 895 2.30857958291927 2.6743351185864 3.07815609688374 6.42381665951263 7.81668023990459 6.81834255212598 2.68702359946314 7.0196131505144 -1.38538253384343 1.49784217341743e-10 3.82519933662994e-09 DOWN ENSG00000162623 TYW3 tRNA-yW synthesizing protein 3 homolog [Source:HGNC Symbol;Acc:HGNC:24757] GO:0009987|GO:0008152|GO:0003824|GO:0032259|GO:0006807|GO:0071704|GO:0044237|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0006139|GO:0008168|GO:0043412|GO:0010467|GO:0016070|GO:0006396|GO:0034660|GO:0009451|GO:0006400|GO:0006399|GO:0008033 cellular process|metabolic process|catalytic activity|methylation|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|methyltransferase activity|macromolecule modification|gene expression|RNA metabolic process|RNA processing|ncRNA metabolic process|RNA modification|tRNA modification|tRNA metabolic process|tRNA processing - - - - 1:74733152-74766678 964 1103 1121 490 541 501 9.66005598634059 10.0451884781396 10.1279729010608 4.39943219803886 4.44803284443026 4.70510255312516 9.94440578851366 4.51752253186476 1.13835337100374 1.50414159741165e-10 3.83800369650661e-09 UP ENSG00000120658 ENOX1 ecto-NOX disulfide-thiol exchanger 1 [Source:HGNC Symbol;Acc:HGNC:25474] GO:0005623|GO:0048511|GO:0016020|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0071944|GO:0005615|GO:0005515|GO:0005886|GO:0003676|GO:0000166|GO:0055114 cell|rhythmic process|membrane|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|cell periphery|extracellular space|protein binding|plasma membrane|nucleic acid binding|nucleotide binding|oxidation-reduction process - - - - 13:43213518-43786908 0 1 11 41 68 57 0 0.0161318602299823 0.175953147175064 0.651747875485868 0.989870568501857 0.947775546471719 0.0640283358016821 0.863131330153148 -3.75279767242412 1.51938229536244e-10 3.87358147273701e-09 DOWN ENSG00000163009 C2orf48 chromosome 2 open reading frame 48 [Source:HGNC Symbol;Acc:HGNC:26322] - - - - - - 2:10141382-10211725 1 2 1 26 22 48 0.0313682151695983 0.0569922890771893 0.0282556196009949 0.730424667360664 0.565987550849005 1.4105225525855 0.0388720412825942 0.902311590265056 -4.53682094256872 1.5351480149622e-10 3.91043590773733e-09 DOWN ENSG00000189223 PAX8-AS1 PAX8 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49271] - - - - - - 2:113211522-113276581 251 305 568 1135 1171 1616 0.65790760595289 0.726559364092862 1.34231293056586 2.66553760239396 2.5183491392176 3.9697348067484 0.908926633537204 3.05120718278665 -1.74714439177396 1.55241266027842e-10 3.95104241772822e-09 DOWN ENSG00000102057 KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 [Source:HGNC Symbol;Acc:HGNC:6237] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0022857|GO:0050794|GO:0043167|GO:0044297|GO:0016043|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0043025|GO:0006810|GO:0098797|GO:0022607|GO:0005887|GO:0043169|GO:0007267|GO:0043005|GO:0036477|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0071804|GO:0016021|GO:0046872|GO:0015267|GO:0006811|GO:0015075|GO:0008076|GO:0030425|GO:0034765|GO:0034702|GO:0006461|GO:0043269|GO:0071805|GO:0034220|GO:0098655|GO:0005216|GO:0051259|GO:0034703|GO:0006812|GO:0008324|GO:0005244|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:0051260|GO:0015672|GO:0007268|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249|GO:0015271|GO:0005250 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|binding|cell projection|transmembrane transporter activity|regulation of cellular process|ion binding|cell body|cellular component organization|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|protein complex|neuronal cell body|transport|plasma membrane protein complex|cellular component assembly|integral component of plasma membrane|cation binding|cell-cell signaling|neuron projection|somatodendritic compartment|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|cellular potassium ion transport|integral component of membrane|metal ion binding|channel activity|ion transport|ion transmembrane transporter activity|voltage-gated potassium channel complex|dendrite|regulation of ion transmembrane transport|ion channel complex|protein complex assembly|regulation of ion transport|potassium ion transmembrane transport|ion transmembrane transport|cation transmembrane transport|ion channel activity|protein oligomerization|cation channel complex|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|protein homooligomerization|monovalent inorganic cation transport|synaptic transmission|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity|outward rectifier potassium channel activity|A-type (transient outward) potassium channel activity - - - - X:48961378-48971569 109 95 164 16 14 37 1.0005609650362 0.792541412168371 1.3572973701072 0.131589608551429 0.105442052697552 0.318304521928001 1.05013324910392 0.185112061058994 2.5041015970917 1.55452827926639e-10 3.95305683553823e-09 UP ENSG00000070495 JMJD6 jumonji domain containing 6 [Source:HGNC Symbol;Acc:HGNC:19355] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0004872|GO:0032451|GO:0016491|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0002262|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0007507|GO:0016337|GO:0006725|GO:0060041|GO:0001822|GO:0048468|GO:0051213|GO:0006810|GO:0035295|GO:1901360|GO:0001568|GO:0007275|GO:0030324|GO:0016570|GO:0003676|GO:0048513|GO:0070489|GO:0034101|GO:0034641|GO:0032452|GO:0046483|GO:0006482|GO:0098609|GO:0043231|GO:0043169|GO:0005737|GO:0030529|GO:0016705|GO:0007423|GO:0042592|GO:0001775|GO:0046983|GO:0070988|GO:0008037|GO:0030323|GO:0006139|GO:0001525|GO:0046649|GO:0007154|GO:0007165|GO:0048869|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0055114|GO:0016192|GO:0051276|GO:0005730|GO:0006909|GO:0005829|GO:0002040|GO:0010468|GO:0006910|GO:0034645|GO:0030218|GO:0046872|GO:0003723|GO:0007166|GO:0001654|GO:0001944|GO:0043412|GO:0030097|GO:0072358|GO:0030098|GO:0001655|GO:0051252|GO:0060541|GO:0006325|GO:0033746|GO:0036211|GO:0048872|GO:0072001|GO:0031981|GO:0007159|GO:0016706|GO:0005654|GO:0016577|GO:0042116|GO:0042110|GO:0044267|GO:0010467|GO:0009059|GO:0033749|GO:0030154|GO:0016070|GO:0072359|GO:0005634|GO:0042803|GO:0002521|GO:0043654|GO:0006396|GO:0043010|GO:0050684|GO:0032774|GO:2001141|GO:0030217|GO:0043484|GO:0070486|GO:0016071|GO:0070815|GO:0033077|GO:0046914|GO:0016568|GO:0043277|GO:0048821|GO:0030099|GO:0006897|GO:0006464|GO:0003727|GO:0006351|GO:0006355|GO:0005506|GO:0018126|GO:1903506|GO:0048024|GO:0006397|GO:0018193|GO:0008380|GO:0070079|GO:0071593|GO:0070078|GO:0000375|GO:0018205|GO:0017185|GO:0000398|GO:0018395 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|receptor activity|demethylase activity|oxidoreductase activity|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|myeloid cell homeostasis|biosynthetic process|intracellular|immune system development|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|heart development|single organismal cell-cell adhesion|cellular aromatic compound metabolic process|retina development in camera-type eye|kidney development|cell development|dioxygenase activity|transport|tube development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|lung development|histone modification|nucleic acid binding|animal organ development|T cell aggregation|erythrocyte homeostasis|cellular nitrogen compound metabolic process|histone demethylase activity|heterocycle metabolic process|protein demethylation|cell-cell adhesion|intracellular membrane-bounded organelle|cation binding|cytoplasm|intracellular ribonucleoprotein complex|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|sensory organ development|homeostatic process|cell activation|protein dimerization activity|demethylation|cell recognition|respiratory tube development|nucleobase-containing compound metabolic process|angiogenesis|lymphocyte activation|cell communication|signal transduction|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|vesicle-mediated transport|chromosome organization|nucleolus|phagocytosis|cytosol|sprouting angiogenesis|regulation of gene expression|phagocytosis, recognition|cellular macromolecule biosynthetic process|erythrocyte differentiation|metal ion binding|RNA binding|cell surface receptor signaling pathway|eye development|vasculature development|macromolecule modification|hemopoiesis|cardiovascular system development|lymphocyte differentiation|urogenital system development|regulation of RNA metabolic process|respiratory system development|chromatin organization|histone demethylase activity (H3-R2 specific)|protein modification process|homeostasis of number of cells|renal system development|nuclear lumen|leukocyte cell-cell adhesion|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|nucleoplasm|histone demethylation|macrophage activation|T cell activation|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|histone demethylase activity (H4-R3 specific)|cell differentiation|RNA metabolic process|circulatory system development|nucleus|protein homodimerization activity|leukocyte differentiation|recognition of apoptotic cell|RNA processing|camera-type eye development|regulation of mRNA processing|RNA biosynthetic process|regulation of RNA biosynthetic process|T cell differentiation|regulation of RNA splicing|leukocyte aggregation|mRNA metabolic process|peptidyl-lysine 5-dioxygenase activity|T cell differentiation in thymus|transition metal ion binding|chromatin modification|apoptotic cell clearance|erythrocyte development|myeloid cell differentiation|endocytosis|cellular protein modification process|single-stranded RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|iron ion binding|protein hydroxylation|regulation of nucleic acid-templated transcription|regulation of mRNA splicing, via spliceosome|mRNA processing|peptidyl-amino acid modification|RNA splicing|histone H4-R3 demethylation|lymphocyte aggregation|histone H3-R2 demethylation|RNA splicing, via transesterification reactions|peptidyl-lysine modification|peptidyl-lysine hydroxylation|mRNA splicing, via spliceosome|peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine - - - - 17:76712832-76726799 1241 1017 1094 483 555 390 10.2683853862475 7.64771054958326 8.16135064672519 3.58075726501373 3.76783253093 3.02429342236853 8.69248219418532 3.45762773943742 1.32998565508146 1.61034200575529e-10 4.09150214806964e-09 UP ENSG00000117298 ECE1 endothelin converting enzyme 1 [Source:HGNC Symbol;Acc:HGNC:3146] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0033218|GO:0050794|GO:0042562|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0009986|GO:0044237|GO:0042445|GO:0023051|GO:0009653|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0007507|GO:0042277|GO:0017046|GO:0009897|GO:0006725|GO:0009612|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0030141|GO:0043231|GO:0043169|GO:0008233|GO:0001881|GO:0005774|GO:0005737|GO:0003012|GO:0016486|GO:0007423|GO:0001921|GO:0031302|GO:0009966|GO:0046983|GO:0048598|GO:0042493|GO:0010646|GO:0006139|GO:0055086|GO:0007154|GO:0007165|GO:0070062|GO:0008219|GO:0001666|GO:0042447|GO:0001919|GO:0008217|GO:0010008|GO:0010817|GO:0016021|GO:0010035|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031323|GO:0003013|GO:0005768|GO:0000165|GO:0032268|GO:0007186|GO:0035150|GO:0006518|GO:0010613|GO:0046872|GO:0033093|GO:0042733|GO:0043412|GO:0043171|GO:0072358|GO:0031410|GO:0043583|GO:0019693|GO:0008277|GO:0005769|GO:0051604|GO:0005773|GO:0009790|GO:0090257|GO:0010038|GO:0016023|GO:0010816|GO:0036211|GO:0060037|GO:0035994|GO:0048471|GO:0006508|GO:0031988|GO:0002002|GO:0012501|GO:0006796|GO:0043603|GO:0035556|GO:1901137|GO:0035108|GO:0044267|GO:0051174|GO:0010611|GO:0014896|GO:0010467|GO:0034959|GO:0031328|GO:0051246|GO:0045745|GO:0060173|GO:1902531|GO:0072359|GO:0008015|GO:0042803|GO:0003073|GO:0043112|GO:0008237|GO:0009792|GO:0042312|GO:0009259|GO:0046686|GO:0043408|GO:0000323|GO:0016485|GO:0003081|GO:0009117|GO:0046390|GO:0016310|GO:0070371|GO:0019229|GO:0003100|GO:0030135|GO:0004175|GO:0010815|GO:0006163|GO:0010813|GO:0060177|GO:0006464|GO:0009165|GO:0030326|GO:0005765|GO:0006915|GO:0050880|GO:0003300|GO:0030136|GO:0006164|GO:0030801|GO:0005764|GO:0006468|GO:0042311|GO:0001991|GO:0042325|GO:0001932|GO:0042310|GO:0010814|GO:0009187|GO:0043009|GO:0070372|GO:0004222|GO:0030802|GO:0009190|GO:0046058|GO:0030819|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030816|GO:0006171 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|amide binding|regulation of cellular process|hormone binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cell surface|cellular metabolic process|hormone metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|heart development|peptide binding|peptide hormone binding|external side of plasma membrane|cellular aromatic compound metabolic process|response to mechanical stimulus|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|secretory granule|intracellular membrane-bounded organelle|cation binding|peptidase activity|receptor recycling|vacuolar membrane|cytoplasm|muscle system process|peptide hormone processing|sensory organ development|positive regulation of receptor recycling|intrinsic component of endosome membrane|regulation of signal transduction|protein dimerization activity|embryonic morphogenesis|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|extracellular exosome|cell death|response to hypoxia|hormone catabolic process|regulation of receptor recycling|regulation of blood pressure|endosome membrane|regulation of hormone levels|integral component of membrane|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|circulatory system process|endosome|MAPK cascade|regulation of cellular protein metabolic process|G-protein coupled receptor signaling pathway|regulation of tube size|peptide metabolic process|positive regulation of cardiac muscle hypertrophy|metal ion binding|Weibel-Palade body|embryonic digit morphogenesis|macromolecule modification|peptide catabolic process|cardiovascular system development|cytoplasmic vesicle|ear development|ribose phosphate metabolic process|regulation of G-protein coupled receptor protein signaling pathway|early endosome|protein maturation|vacuole|embryo development|regulation of muscle system process|response to metal ion|cytoplasmic, membrane-bounded vesicle|calcitonin catabolic process|protein modification process|pharyngeal system development|response to muscle stretch|perinuclear region of cytoplasm|proteolysis|membrane-bounded vesicle|regulation of angiotensin levels in blood|programmed cell death|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|limb morphogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of cardiac muscle hypertrophy|muscle hypertrophy|gene expression|endothelin maturation|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of G-protein coupled receptor protein signaling pathway|limb development|regulation of intracellular signal transduction|circulatory system development|blood circulation|protein homodimerization activity|regulation of systemic arterial blood pressure|receptor metabolic process|metallopeptidase activity|embryo development ending in birth or egg hatching|regulation of vasodilation|ribonucleotide metabolic process|response to cadmium ion|regulation of MAPK cascade|lytic vacuole|protein processing|regulation of systemic arterial blood pressure by renin-angiotensin|nucleotide metabolic process|ribose phosphate biosynthetic process|phosphorylation|ERK1 and ERK2 cascade|regulation of vasoconstriction|regulation of systemic arterial blood pressure by endothelin|coated vesicle|endopeptidase activity|bradykinin catabolic process|purine nucleotide metabolic process|neuropeptide catabolic process|regulation of angiotensin metabolic process|cellular protein modification process|nucleotide biosynthetic process|embryonic limb morphogenesis|lysosomal membrane|apoptotic process|regulation of blood vessel size|cardiac muscle hypertrophy|clathrin-coated vesicle|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|lysosome|protein phosphorylation|vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|regulation of phosphorylation|regulation of protein phosphorylation|vasoconstriction|substance P catabolic process|cyclic nucleotide metabolic process|chordate embryonic development|regulation of ERK1 and ERK2 cascade|metalloendopeptidase activity|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|cAMP metabolic process|positive regulation of cAMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|positive regulation of cAMP metabolic process|cAMP biosynthetic process - - - - 1:21217247-21345504 431 414 821 1610 1753 2348 2.72966158483843 2.38293525920409 4.6880125658564 9.13597549588624 9.10922179385588 13.9366517402403 3.26686980329964 10.7272830099941 -1.71530385437988 1.61234987349164e-10 4.09312016353907e-09 DOWN ENSG00000167377 ZNF23 zinc finger protein 23 [Source:HGNC Symbol;Acc:HGNC:13023] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 16:71447597-71463095 379 338 362 131 131 144 1.35345548187142 1.09698647529915 1.16554190668551 0.419154036729662 0.383836228695977 0.481943968050699 1.20532795461869 0.428311411158779 1.492693719668 1.62335936520536e-10 4.1175675861377e-09 UP ENSG00000106125 FAM188B family with sequence similarity 188 member B [Source:HGNC Symbol;Acc:HGNC:21916] - - - - - - 7:30771417-30892387 25 37 56 197 234 134 0.212706093953268 0.286103031222449 0.429577118530457 1.50175742063605 1.63350072149341 1.06848907248264 0.309462081235391 1.40124907153737 -2.1788788669002 1.64289385993984e-10 4.16357837815315e-09 DOWN ENSG00000118804 STBD1 starch binding domain 1 [Source:HGNC Symbol;Acc:HGNC:24854] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0030246|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0044262|GO:0015980|GO:0005887|GO:0043231|GO:0005737|GO:0003012|GO:0005975|GO:0031226|GO:0005783|GO:0030247|GO:0034045|GO:0016236|GO:0006091|GO:0016021|GO:0055114|GO:0005976|GO:0006936|GO:2001069|GO:2001070|GO:0044275|GO:0005977|GO:0048471|GO:0016052|GO:0006112|GO:0061723|GO:0000407|GO:0005980|GO:0000272 cell|membrane|cellular process|metabolic process|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|carbohydrate binding|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|cellular carbohydrate metabolic process|energy derivation by oxidation of organic compounds|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|muscle system process|carbohydrate metabolic process|intrinsic component of plasma membrane|endoplasmic reticulum|polysaccharide binding|pre-autophagosomal structure membrane|macroautophagy|generation of precursor metabolites and energy|integral component of membrane|oxidation-reduction process|polysaccharide metabolic process|muscle contraction|glycogen binding|starch binding|cellular carbohydrate catabolic process|glycogen metabolic process|perinuclear region of cytoplasm|carbohydrate catabolic process|energy reserve metabolic process|glycophagy|pre-autophagosomal structure|glycogen catabolic process|polysaccharide catabolic process - - - - 4:76306026-76311599 481 450 632 219 195 212 9.94865523694927 8.45887332891725 11.7855733591413 4.05845784628844 3.30919508351998 4.10945641486441 10.0643673083359 3.82570311489094 1.39545965474439 1.71218319399266e-10 4.33549763133645e-09 UP ENSG00000163811 WDR43 WD repeat domain 43 [Source:HGNC Symbol;Acc:HGNC:28945] GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0044877|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0007049|GO:0051640|GO:0006810|GO:0022402|GO:0005938|GO:0003676|GO:0005874|GO:0000776|GO:0043231|GO:0005737|GO:0045502|GO:0006928|GO:0032403|GO:0051656|GO:0005875|GO:0007163|GO:0010970|GO:0051649|GO:0008092|GO:0050790|GO:0007017|GO:0006996|GO:0031023|GO:0051650|GO:0005730|GO:0015631|GO:0051653|GO:0005813|GO:0003723|GO:1903047|GO:0007010|GO:0005815|GO:0008017|GO:0000278|GO:0046907|GO:0031981|GO:0030010|GO:0007018|GO:0051647|GO:0005694|GO:0051293|GO:0051648|GO:0000226|GO:0072384|GO:0005856|GO:0005634|GO:0040023|GO:0047496|GO:0051294|GO:0015630|GO:0040001|GO:0000132|GO:0007097|GO:0044822|GO:2000574|GO:0030705|GO:0000775 macromolecular complex|reproduction|cell|cellular process|metabolic process|binding|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|protein complex|regulation of metabolic process|cell cycle|organelle localization|transport|cell cycle process|cell cortex|nucleic acid binding|microtubule|kinetochore|intracellular membrane-bounded organelle|cytoplasm|dynein binding|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|microtubule associated complex|establishment or maintenance of cell polarity|establishment of localization by movement along microtubule|establishment of localization in cell|cytoskeletal protein binding|regulation of catalytic activity|microtubule-based process|organelle organization|microtubule organizing center organization|establishment of vesicle localization|nucleolus|tubulin binding|spindle localization|centrosome|RNA binding|mitotic cell cycle process|cytoskeleton organization|microtubule organizing center|microtubule binding|mitotic cell cycle|intracellular transport|nuclear lumen|establishment of cell polarity|microtubule-based movement|nucleus localization|chromosome|establishment of spindle localization|vesicle localization|microtubule cytoskeleton organization|organelle transport along microtubule|cytoskeleton|nucleus|establishment of nucleus localization|vesicle transport along microtubule|establishment of spindle orientation|microtubule cytoskeleton|establishment of mitotic spindle localization|establishment of mitotic spindle orientation|nuclear migration|poly(A) RNA binding|regulation of microtubule motor activity|cytoskeleton-dependent intracellular transport|chromosome, centromeric region K14546 U3 small nucleolar RNA-associated protein 5[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 2:28894643-28948222 4078 4439 3531 1650 1871 1027 62.95610091975 62.2810409099829 49.1476344651775 22.8229769313869 23.6991259017316 14.8590120099771 58.1282587649701 20.4603716143652 1.50640734473974 1.71972413528115e-10 4.35090206226132e-09 UP ENSG00000128881 TTBK2 tau tubulin kinase 2 [Source:HGNC Symbol;Acc:HGNC:19141] GO:0032502|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0005615|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0005929|GO:0048646|GO:0043168|GO:0001882|GO:0016772|GO:0022607|GO:0005882|GO:0043231|GO:0005737|GO:0072372|GO:0036064|GO:0007154|GO:0007165|GO:0035869|GO:0000166|GO:0030030|GO:0048869|GO:0019538|GO:0006996|GO:0000902|GO:0005829|GO:0005813|GO:0007166|GO:0035639|GO:0043412|GO:0005815|GO:0001883|GO:0005814|GO:0036211|GO:0044782|GO:0032549|GO:0030031|GO:0016301|GO:0045095|GO:0070925|GO:0006796|GO:0042384|GO:0044267|GO:0032990|GO:0017076|GO:0048858|GO:0016773|GO:0005856|GO:0005634|GO:0031513|GO:0060271|GO:0005524|GO:0007224|GO:0030554|GO:0016310|GO:0015630|GO:0045111|GO:0004672|GO:0006464|GO:0006468|GO:0018193|GO:0004674|GO:0018105 developmental process|structural molecule activity|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|extracellular space|intracellular|protein binding|transferase activity|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular component assembly|intermediate filament|intracellular membrane-bounded organelle|cytoplasm|primary cilium|ciliary basal body|cell communication|signal transduction|ciliary transition zone|nucleotide binding|cell projection organization|cellular developmental process|protein metabolic process|organelle organization|cell morphogenesis|cytosol|centrosome|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|microtubule organizing center|purine nucleoside binding|centriole|protein modification process|cilium organization|ribonucleoside binding|cell projection assembly|kinase activity|keratin filament|organelle assembly|phosphate-containing compound metabolic process|cilium assembly|cellular protein metabolic process|cell part morphogenesis|purine nucleotide binding|cell projection morphogenesis|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|nonmotile primary cilium|cilium morphogenesis|ATP binding|smoothened signaling pathway|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|intermediate filament cytoskeleton|protein kinase activity|cellular protein modification process|protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|peptidyl-serine phosphorylation - - - - 15:42738734-42920809 71 115 174 462 413 696 0.299857596432077 0.441403675667255 0.662553827333763 1.74822330474518 1.43111632886903 2.75483080520776 0.467938366477698 1.97805681294066 -2.07969343731302 1.72912888903848e-10 4.37099185887847e-09 DOWN ENSG00000134508 CABLES1 Cdk5 and Abl enzyme substrate 1 [Source:HGNC Symbol;Acc:HGNC:25097] GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0050794|GO:0043229|GO:0006950|GO:0043227|GO:0005622|GO:0005515|GO:0051726|GO:0007049|GO:0050817|GO:0043231|GO:0005737|GO:0009611|GO:0051301|GO:0050878|GO:0005829|GO:0007596|GO:0042060|GO:0007599|GO:0005634 cell|cellular process|response to stimulus|binding|regulation of cellular process|intracellular organelle|response to stress|membrane-bounded organelle|intracellular|protein binding|regulation of cell cycle|cell cycle|coagulation|intracellular membrane-bounded organelle|cytoplasm|response to wounding|cell division|regulation of body fluid levels|cytosol|blood coagulation|wound healing|hemostasis|nucleus - - - - 18:23134564-23260467 95 100 143 344 405 349 0.605186118006639 0.578956250712081 0.821328153484506 1.96346433685326 2.11684401437315 2.08362899167778 0.668490174067742 2.05464578096806 -1.61991143619882 1.74306398629943e-10 4.40249003781584e-09 DOWN ENSG00000077157 PPP1R12B protein phosphatase 1 regulatory subunit 12B [Source:HGNC Symbol;Acc:HGNC:7619] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0043227|GO:0071944|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0030017|GO:0030018|GO:0007049|GO:0022402|GO:0019208|GO:0008047|GO:0043231|GO:0019899|GO:0005737|GO:0003012|GO:0031672|GO:0031674|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005829|GO:0006936|GO:1903047|GO:0044770|GO:0090257|GO:0000278|GO:0043292|GO:0031981|GO:0005654|GO:0019900|GO:0035556|GO:0005856|GO:0005634|GO:0015629|GO:0030016|GO:0006937|GO:0000086|GO:0044772|GO:0019901|GO:0007264 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|regulation of metabolic process|sarcomere|Z disc|cell cycle|cell cycle process|phosphatase regulator activity|enzyme activator activity|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|muscle system process|A band|I band|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cytosol|muscle contraction|mitotic cell cycle process|cell cycle phase transition|regulation of muscle system process|mitotic cell cycle|contractile fiber|nuclear lumen|nucleoplasm|kinase binding|intracellular signal transduction|cytoskeleton|nucleus|actin cytoskeleton|myofibril|regulation of muscle contraction|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|protein kinase binding|small GTPase mediated signal transduction K12329 protein phosphatase 1 regulatory subunit 12B[-] hsa04810|hsa05205|hsa04510|hsa04921|hsa04270 Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human) 1:202348699-202592706 179 174 547 1219 1397 1796 0.511694119449876 0.45205053795749 1.40980777286025 3.1221928688682 3.27659486293322 4.81164470597967 0.791184143422539 3.7368108125937 -2.23972210712919 1.77670742433917e-10 4.48367062098239e-09 DOWN ENSG00000240038 AMY2B amylase, alpha 2B (pancreatic) [Source:HGNC Symbol;Acc:HGNC:478] GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0071704|GO:0043167|GO:0043227|GO:0016787|GO:0016798|GO:0031982|GO:0043169|GO:0005975|GO:0070062|GO:0007586|GO:0046872|GO:0004553|GO:0016160|GO:0004556 extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|organic substance metabolic process|ion binding|membrane-bounded organelle|hydrolase activity|hydrolase activity, acting on glycosyl bonds|vesicle|cation binding|carbohydrate metabolic process|extracellular exosome|digestion|metal ion binding|hydrolase activity, hydrolyzing O-glycosyl compounds|amylase activity|alpha-amylase activity K01176 alpha-amylase[3.2.1.1] hsa01100|hsa04972|hsa00500|hsa04973 Metabolic pathways - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Carbohydrate digestion and absorption - Homo sapiens (human) 1:103553815-103579534 44 60 89 6 7 17 0.330229102558839 0.409256034455615 0.602236578973279 0.0403485533836614 0.043105382391901 0.119575459408171 0.447240571995911 0.0676764650612445 2.72432495065152 1.80598067716019e-10 4.55369485945442e-09 UP ENSG00000185252 ZNF74 zinc finger protein 74 [Source:HGNC Symbol;Acc:HGNC:13144] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0003723|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0015629|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|actin cytoskeleton|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 22:20394115-20408461 616 667 523 237 259 229 1.62177790924094 1.595937952635 1.24144286287999 0.559058403350807 0.559470982330905 0.565034228217891 1.48638624158531 0.561187871299868 1.4052533188078 1.82588724416397e-10 4.60000318879925e-09 UP ENSG00000186298 PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme [Source:HGNC Symbol;Acc:HGNC:9283] GO:0032502|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0030496|GO:0042752|GO:0051716|GO:0042995|GO:0097159|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0007623|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0009986|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0019867|GO:0009605|GO:0023057|GO:0016787|GO:0008287|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0031090|GO:0019222|GO:0047485|GO:0060341|GO:0044262|GO:0007049|GO:0044255|GO:0008022|GO:0009314|GO:0006810|GO:0072357|GO:0007275|GO:0003676|GO:0015980|GO:0016788|GO:0005924|GO:0000776|GO:0044281|GO:0005912|GO:0090287|GO:0032922|GO:0043231|GO:0043169|GO:0019899|GO:0005521|GO:0005737|GO:0005975|GO:0071559|GO:0032403|GO:0043005|GO:0009966|GO:0031966|GO:0043197|GO:0036477|GO:0019904|GO:0010646|GO:0090288|GO:0007154|GO:0006629|GO:0007165|GO:0009968|GO:0051649|GO:0006091|GO:0051301|GO:0048869|GO:0019538|GO:0010033|GO:0032154|GO:0009649|GO:0055114|GO:0005730|GO:0005740|GO:0005829|GO:0005976|GO:0010468|GO:0046486|GO:0046872|GO:0003723|GO:0090101|GO:0007166|GO:0043412|GO:0044309|GO:0016042|GO:0005741|GO:0044242|GO:0032386|GO:0036211|GO:0000278|GO:0071560|GO:0046907|GO:0019902|GO:0006638|GO:0031981|GO:1990234|GO:0030425|GO:0005977|GO:0070848|GO:0005654|GO:0005739|GO:0005694|GO:0019900|GO:0006112|GO:0006796|GO:0035556|GO:0044267|GO:0010467|GO:0007399|GO:0071310|GO:0030154|GO:0035097|GO:0005634|GO:0009416|GO:0042578|GO:0000777|GO:0005925|GO:0043153|GO:0030182|GO:0016311|GO:0000781|GO:0051169|GO:0000793|GO:0071363|GO:0046461|GO:0009648|GO:0007179|GO:0016604|GO:0070688|GO:0030512|GO:0016482|GO:0019903|GO:0007167|GO:0016791|GO:0044822|GO:0006639|GO:0019901|GO:0022008|GO:0007264|GO:0006464|GO:0017015|GO:0000775|GO:0016607|GO:0006470|GO:0006913|GO:0000779|GO:0048699|GO:0008157|GO:0004721|GO:0046464|GO:0007178|GO:0006641|GO:0046822|GO:0004722|GO:0019433 developmental process|macromolecular complex|synapse|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|midbody|regulation of circadian rhythm|cellular response to stimulus|cell projection|organic cyclic compound binding|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|circadian rhythm|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cell surface|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|outer membrane|response to external stimulus|negative regulation of signaling|hydrolase activity|protein serine/threonine phosphatase complex|intracellular|protein binding|protein complex|anatomical structure development|organelle membrane|regulation of metabolic process|protein N-terminus binding|regulation of cellular localization|cellular carbohydrate metabolic process|cell cycle|cellular lipid metabolic process|protein C-terminus binding|response to radiation|transport|PTW/PP1 phosphatase complex|multicellular organism development|nucleic acid binding|energy derivation by oxidation of organic compounds|hydrolase activity, acting on ester bonds|cell-substrate adherens junction|kinetochore|small molecule metabolic process|adherens junction|regulation of cellular response to growth factor stimulus|circadian regulation of gene expression|intracellular membrane-bounded organelle|cation binding|enzyme binding|lamin binding|cytoplasm|carbohydrate metabolic process|response to transforming growth factor beta|protein complex binding|neuron projection|regulation of signal transduction|mitochondrial membrane|dendritic spine|somatodendritic compartment|protein domain specific binding|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|cell communication|lipid metabolic process|signal transduction|negative regulation of signal transduction|establishment of localization in cell|generation of precursor metabolites and energy|cell division|cellular developmental process|protein metabolic process|response to organic substance|cleavage furrow|entrainment of circadian clock|oxidation-reduction process|nucleolus|mitochondrial envelope|cytosol|polysaccharide metabolic process|regulation of gene expression|glycerolipid metabolic process|metal ion binding|RNA binding|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|macromolecule modification|neuron spine|lipid catabolic process|mitochondrial outer membrane|cellular lipid catabolic process|regulation of intracellular transport|protein modification process|mitotic cell cycle|cellular response to transforming growth factor beta stimulus|intracellular transport|phosphatase binding|neutral lipid metabolic process|nuclear lumen|transferase complex|dendrite|glycogen metabolic process|response to growth factor|nucleoplasm|mitochondrion|chromosome|kinase binding|energy reserve metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|nervous system development|cellular response to organic substance|cell differentiation|histone methyltransferase complex|nucleus|response to light stimulus|phosphoric ester hydrolase activity|condensed chromosome kinetochore|focal adhesion|entrainment of circadian clock by photoperiod|neuron differentiation|dephosphorylation|chromosome, telomeric region|nuclear transport|condensed chromosome|cellular response to growth factor stimulus|neutral lipid catabolic process|photoperiodism|transforming growth factor beta receptor signaling pathway|nuclear body|MLL5-L complex|negative regulation of transforming growth factor beta receptor signaling pathway|cytosolic transport|protein phosphatase binding|enzyme linked receptor protein signaling pathway|phosphatase activity|poly(A) RNA binding|acylglycerol metabolic process|protein kinase binding|neurogenesis|small GTPase mediated signal transduction|cellular protein modification process|regulation of transforming growth factor beta receptor signaling pathway|chromosome, centromeric region|nuclear speck|protein dephosphorylation|nucleocytoplasmic transport|condensed chromosome, centromeric region|generation of neurons|protein phosphatase 1 binding|phosphoprotein phosphatase activity|acylglycerol catabolic process|transmembrane receptor protein serine/threonine kinase signaling pathway|triglyceride metabolic process|regulation of nucleocytoplasmic transport|protein serine/threonine phosphatase activity|triglyceride catabolic process K06269 serine/threonine-protein phosphatase PP1 catalytic subunit[3.1.3.16] hsa04810|hsa05205|hsa04510|hsa04024|hsa05168|hsa05034|hsa04022|hsa04921|hsa04390|hsa04261|hsa04910|hsa04728|hsa04611|hsa04114|hsa04270|hsa04931|hsa04750|hsa03015|hsa05031|hsa04720 Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human) 12:110719680-110742939 809 849 1520 2863 3378 3183 4.5854275635814 4.37339829640253 7.76763642608674 14.5395238560992 15.7093716422993 16.9081764291208 5.57548742869022 15.7190239758398 -1.49534179956673 1.85409628338955e-10 4.66713241520333e-09 DOWN ENSG00000145012 LPP LIM domain containing preferred translocation partner in lipoma [Source:HGNC Symbol;Acc:HGNC:6679] GO:0005623|GO:0016020|GO:0030054|GO:0005488|GO:0030055|GO:0043229|GO:0043167|GO:0007155|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0005924|GO:0005912|GO:0043231|GO:0043169|GO:0005737|GO:0046872|GO:0005634|GO:0005925|GO:0046914|GO:0008270 cell|membrane|cell junction|binding|cell-substrate junction|intracellular organelle|ion binding|cell adhesion|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|cell-substrate adherens junction|adherens junction|intracellular membrane-bounded organelle|cation binding|cytoplasm|metal ion binding|nucleus|focal adhesion|transition metal ion binding|zinc ion binding - - - - 3:188153284-188890671 163 198 659 1291 4112 2855 0.398925162738004 0.440400159556301 1.45412707739672 2.8309134544234 8.25703015864092 6.54844020337925 0.764484133230342 5.87879460548119 -2.9429619095448 1.89130110763981e-10 4.75677365353656e-09 DOWN ENSG00000155066 PROM2 prominin 2 [Source:HGNC Symbol;Acc:HGNC:20685] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0036094|GO:1903561|GO:0042995|GO:0097159|GO:0048523|GO:0050794|GO:0071704|GO:0009986|GO:0051051|GO:0044237|GO:0045177|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0031224|GO:0005622|GO:0005886|GO:0005929|GO:0031090|GO:0019222|GO:0016323|GO:0006810|GO:0051130|GO:0016324|GO:0060627|GO:0005496|GO:0045806|GO:0060170|GO:0031982|GO:0031325|GO:0051128|GO:0005887|GO:0043178|GO:0005737|GO:0031226|GO:0070062|GO:0044393|GO:0050790|GO:0030030|GO:0031253|GO:0016021|GO:0019538|GO:0098857|GO:0031323|GO:0071914|GO:0016192|GO:0032268|GO:0031344|GO:0048550|GO:0043412|GO:0031410|GO:0031528|GO:0048261|GO:0031346|GO:0036211|GO:0032934|GO:0030100|GO:0051247|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0005902|GO:0051246|GO:0045121|GO:0031401|GO:0048259|GO:0043087|GO:0016310|GO:2001287|GO:0015485|GO:0006897|GO:0006464|GO:0006468|GO:0042325|GO:0001932|GO:0006898|GO:0001934|GO:0006907|GO:2001286|GO:0042327|GO:0072584 cell|membrane|cellular process|extracellular region|metabolic process|binding|small molecule binding|extracellular vesicle|cell projection|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|cell surface|negative regulation of transport|cellular metabolic process|apical part of cell|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|intrinsic component of membrane|intracellular|plasma membrane|cilium|organelle membrane|regulation of metabolic process|basolateral plasma membrane|transport|positive regulation of cellular component organization|apical plasma membrane|regulation of vesicle-mediated transport|steroid binding|negative regulation of endocytosis|ciliary membrane|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|integral component of plasma membrane|alcohol binding|cytoplasm|intrinsic component of plasma membrane|extracellular exosome|microspike|regulation of catalytic activity|cell projection organization|cell projection membrane|integral component of membrane|protein metabolic process|membrane microdomain|regulation of cellular metabolic process|prominosome|vesicle-mediated transport|regulation of cellular protein metabolic process|regulation of cell projection organization|negative regulation of pinocytosis|macromolecule modification|cytoplasmic vesicle|microvillus membrane|negative regulation of receptor-mediated endocytosis|positive regulation of cell projection organization|protein modification process|sterol binding|regulation of endocytosis|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|microvillus|regulation of protein metabolic process|membrane raft|positive regulation of protein modification process|regulation of receptor-mediated endocytosis|regulation of GTPase activity|phosphorylation|negative regulation of caveolin-mediated endocytosis|cholesterol binding|endocytosis|cellular protein modification process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|receptor-mediated endocytosis|positive regulation of protein phosphorylation|pinocytosis|regulation of caveolin-mediated endocytosis|positive regulation of phosphorylation|caveolin-mediated endocytosis - - - - 2:95274453-95291308 1628 1744 2302 4737 4865 6357 9.80499000565972 9.5459494699471 12.5000656483841 25.5619412669373 24.0404992428959 35.8817684911839 10.617001707997 28.4947363336724 -1.42431904356585 1.90845976790245e-10 4.79588871304375e-09 DOWN ENSG00000152137 HSPB8 heat shock protein family B (small) member 8 [Source:HGNC Symbol;Acc:HGNC:30171] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0042802|GO:0043231|GO:0005737|GO:0005794|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|identical protein binding|intracellular membrane-bounded organelle|cytoplasm|Golgi apparatus|nuclear lumen|nucleoplasm|nucleus - - - - 12:119178642-119221131 262 270 295 82 79 116 5.89473755876429 5.52085609457658 5.98410455673583 1.65300176816931 1.45833932993006 2.4459712780919 5.7998994033589 1.85243745873042 1.64660304191483 1.91147272825314e-10 4.79942025477454e-09 UP ENSG00000113273 ARSB arylsulfatase B [Source:HGNC Symbol;Acc:HGNC:714] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0009986|GO:0044237|GO:0051641|GO:0006914|GO:0048870|GO:0016043|GO:0043227|GO:0009605|GO:0016787|GO:0050793|GO:0005622|GO:0012505|GO:0048856|GO:0044255|GO:0045595|GO:0048468|GO:0006810|GO:0051130|GO:0006082|GO:0009991|GO:0007275|GO:0010632|GO:0016788|GO:0044281|GO:0031982|GO:0051128|GO:0045597|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0006928|GO:0009268|GO:0051270|GO:0006629|GO:0016477|GO:0005783|GO:0070062|GO:0051649|GO:0009725|GO:0030030|GO:0048869|GO:2000145|GO:0019538|GO:0010033|GO:0005794|GO:0006996|GO:0006790|GO:0007584|GO:0031175|GO:0031344|GO:0090132|GO:0006665|GO:0046872|GO:0051597|GO:0033993|GO:0043412|GO:0007417|GO:0010720|GO:0008484|GO:0031346|GO:0005773|GO:0030204|GO:0006643|GO:0030334|GO:0001667|GO:0009100|GO:0036211|GO:0046907|GO:0005791|GO:0050769|GO:0005739|GO:0030207|GO:0014070|GO:0044267|GO:0005788|GO:0007399|GO:0005775|GO:0030154|GO:0031667|GO:0048545|GO:0051960|GO:0007033|GO:0048666|GO:0030182|GO:0010975|GO:0006687|GO:0000323|GO:0003943|GO:0043627|GO:0004065|GO:0043202|GO:0006664|GO:0010631|GO:0006029|GO:0030203|GO:0022008|GO:0006464|GO:0050767|GO:0007034|GO:0010976|GO:0045666|GO:0007041|GO:0061582|GO:0005764|GO:0006027|GO:0048699|GO:0043687|GO:0007040|GO:0045664|GO:0061580 locomotion|developmental process|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cell surface|cellular metabolic process|cellular localization|autophagy|cell motility|cellular component organization|membrane-bounded organelle|response to external stimulus|hydrolase activity|regulation of developmental process|intracellular|endomembrane system|anatomical structure development|cellular lipid metabolic process|regulation of cell differentiation|cell development|transport|positive regulation of cellular component organization|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|regulation of epithelial cell migration|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|movement of cell or subcellular component|response to pH|regulation of cellular component movement|lipid metabolic process|cell migration|endoplasmic reticulum|extracellular exosome|establishment of localization in cell|response to hormone|cell projection organization|cellular developmental process|regulation of cell motility|protein metabolic process|response to organic substance|Golgi apparatus|organelle organization|sulfur compound metabolic process|response to nutrient|neuron projection development|regulation of cell projection organization|epithelium migration|sphingolipid metabolic process|metal ion binding|response to methylmercury|response to lipid|macromolecule modification|central nervous system development|positive regulation of cell development|sulfuric ester hydrolase activity|positive regulation of cell projection organization|vacuole|chondroitin sulfate metabolic process|membrane lipid metabolic process|regulation of cell migration|ameboidal-type cell migration|glycoprotein metabolic process|protein modification process|intracellular transport|rough endoplasmic reticulum|positive regulation of neurogenesis|mitochondrion|chondroitin sulfate catabolic process|response to organic cyclic compound|cellular protein metabolic process|endoplasmic reticulum lumen|nervous system development|vacuolar lumen|cell differentiation|response to nutrient levels|response to steroid hormone|regulation of nervous system development|vacuole organization|neuron development|neuron differentiation|regulation of neuron projection development|glycosphingolipid metabolic process|lytic vacuole|N-acetylgalactosamine-4-sulfatase activity|response to estrogen|arylsulfatase activity|lysosomal lumen|glycolipid metabolic process|epithelial cell migration|proteoglycan metabolic process|glycosaminoglycan metabolic process|neurogenesis|cellular protein modification process|regulation of neurogenesis|vacuolar transport|positive regulation of neuron projection development|positive regulation of neuron differentiation|lysosomal transport|intestinal epithelial cell migration|lysosome|glycosaminoglycan catabolic process|generation of neurons|post-translational protein modification|lysosome organization|regulation of neuron differentiation|colon epithelial cell migration K01135 arylsulfatase B[3.1.6.12] hsa01100|hsa04142|hsa00531 Metabolic pathways - Homo sapiens (human)|Lysosome - Homo sapiens (human)|Glycosaminoglycan degradation - Homo sapiens (human) 5:78777209-78986087 35 47 55 170 223 153 0.276746489448818 0.337752472878844 0.392096214765106 1.20437740150789 1.44673821840074 1.13380151400605 0.335531725697589 1.26163904463823 -1.9107781239628 1.91539080011221e-10 4.80521655013024e-09 DOWN ENSG00000172159 FRMD3 FERM domain containing 3 [Source:HGNC Symbol;Acc:HGNC:24125] GO:0005623|GO:0016020|GO:0005488|GO:0019898|GO:0043229|GO:0031224|GO:0005622|GO:0005515|GO:0005737|GO:0008092|GO:0016021|GO:0005856 cell|membrane|binding|extrinsic component of membrane|intracellular organelle|intrinsic component of membrane|intracellular|protein binding|cytoplasm|cytoskeletal protein binding|integral component of membrane|cytoskeleton - - - - 9:83242990-83538546 12 19 35 116 118 242 0.0718284833581721 0.10335836555764 0.188881235886622 0.622095314735543 0.579497094784058 1.35752203140713 0.121356028267478 0.853038146975577 -2.81336448376564 1.95543304847839e-10 4.90155316786513e-09 DOWN ENSG00000225138 CTD-2228K2.7 - - - - - - - 5:473236-480884 58 45 86 229 243 276 0.571333440167145 0.40286297426765 0.763790415681644 2.02112997637861 1.96396902400218 2.54800066522956 0.579328943372146 2.17769988853678 -1.91035049898821 1.96509855261243e-10 4.92164867363183e-09 DOWN ENSG00000261098 RP11-819C21.1 - - - - - - - 11:107312132-107316271 1 0 2 22 22 21 0.0170934042083608 0 0.0308106531385089 0.336790975637275 0.308422201622066 0.33626610783403 0.0159680191156232 0.32715976169779 -4.35673806007745 1.97577891243819e-10 4.94425009655739e-09 DOWN ENSG00000159208 CIART circadian associated repressor of transcription [Source:HGNC Symbol;Acc:HGNC:25200] GO:0007610|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0007622|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0044237|GO:0043227|GO:0044708|GO:0009058|GO:0005622|GO:0005515|GO:0007626|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0045475|GO:0034641|GO:0046483|GO:0032922|GO:0043231|GO:0009890|GO:0006139|GO:0044249|GO:0048512|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0016604|GO:0003690|GO:0006351|GO:0006355|GO:1903507|GO:1903506|GO:0044212|GO:0016605|GO:0001047|GO:0000976|GO:0070888|GO:0001046 behavior|cell|rhythmic process|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|rhythmic behavior|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|single-organism behavior|biosynthetic process|intracellular|protein binding|locomotory behavior|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|locomotor rhythm|cellular nitrogen compound metabolic process|heterocycle metabolic process|circadian regulation of gene expression|intracellular membrane-bounded organelle|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|circadian behavior|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|nuclear body|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|PML body|core promoter binding|transcription regulatory region sequence-specific DNA binding|E-box binding|core promoter sequence-specific DNA binding - - - - 1:150282543-150287093 187 164 182 44 41 67 2.50764090053486 1.99869526842984 2.20043065812951 0.528662255258518 0.451098795578702 0.842030156267361 2.23558894236474 0.607263735701527 1.88025982162591 1.98536010944263e-10 4.96406538587105e-09 UP ENSG00000095485 CWF19L1 CWF19-like 1, cell cycle control (S. pombe) [Source:HGNC Symbol;Acc:HGNC:25613] GO:0008152|GO:0003824 metabolic process|catalytic activity - - - - 10:100232298-100267680 164 221 186 667 625 506 1.72580101325353 2.11358586494082 1.76471049235644 6.28884052796604 5.39629315640542 4.99030320829358 1.86803245685026 5.55847896422168 -1.57317063242748 2.03626373166049e-10 5.08708095773994e-09 DOWN ENSG00000162769 FLVCR1 feline leukemia virus subgroup C cellular receptor 1 [Source:HGNC Symbol;Acc:HGNC:24682] GO:0032502|GO:0040007|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0051641|GO:0009653|GO:0043227|GO:0071944|GO:0002262|GO:0040008|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0031090|GO:0048468|GO:0006810|GO:0001568|GO:0007275|GO:0048513|GO:0034101|GO:0046620|GO:0035265|GO:0005887|GO:0043231|GO:0005737|GO:0060322|GO:0009887|GO:0035264|GO:0042592|GO:0015232|GO:0048598|GO:0048568|GO:0031966|GO:0019725|GO:0031226|GO:0010171|GO:0055085|GO:0048638|GO:0051649|GO:0060323|GO:0048869|GO:0016021|GO:0005740|GO:0048705|GO:0030218|GO:0042733|GO:0001944|GO:0030097|GO:0072358|GO:0048878|GO:0048536|GO:0009790|GO:0046907|GO:0051181|GO:0048872|GO:0055082|GO:0005739|GO:0035108|GO:0048562|GO:0030154|GO:0001501|GO:0060173|GO:0048469|GO:0072359|GO:0048706|GO:0009792|GO:0015886|GO:0006839|GO:0050801|GO:0048704|GO:0048821|GO:0043249|GO:0030099|GO:0030326|GO:0006873|GO:0043009|GO:0097037|GO:0030003|GO:0055065|GO:0006875|GO:0001701|GO:0006879|GO:0055072 developmental process|growth|transporter activity|immune system process|cell|membrane|cellular process|binding|intracellular organelle|cellular localization|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|myeloid cell homeostasis|regulation of growth|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|immune system development|protein binding|plasma membrane|anatomical structure development|organelle membrane|cell development|transport|blood vessel development|multicellular organism development|animal organ development|erythrocyte homeostasis|regulation of organ growth|organ growth|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|head development|organ morphogenesis|multicellular organism growth|homeostatic process|heme transporter activity|embryonic morphogenesis|embryonic organ development|mitochondrial membrane|cellular homeostasis|intrinsic component of plasma membrane|body morphogenesis|transmembrane transport|regulation of developmental growth|establishment of localization in cell|head morphogenesis|cellular developmental process|integral component of membrane|mitochondrial envelope|skeletal system morphogenesis|erythrocyte differentiation|embryonic digit morphogenesis|vasculature development|hemopoiesis|cardiovascular system development|chemical homeostasis|spleen development|embryo development|intracellular transport|cofactor transport|homeostasis of number of cells|cellular chemical homeostasis|mitochondrion|limb morphogenesis|embryonic organ morphogenesis|cell differentiation|skeletal system development|limb development|cell maturation|circulatory system development|embryonic skeletal system development|embryo development ending in birth or egg hatching|heme transport|mitochondrial transport|ion homeostasis|embryonic skeletal system morphogenesis|erythrocyte development|erythrocyte maturation|myeloid cell differentiation|embryonic limb morphogenesis|cellular ion homeostasis|chordate embryonic development|heme export|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|in utero embryonic development|cellular iron ion homeostasis|iron ion homeostasis - - - - 1:212858255-212899363 808 892 958 435 441 349 7.72161163200125 7.74714054361601 8.25422478416129 3.72463404078606 3.45782765582304 3.1257249829222 7.90765898659285 3.43606222651043 1.20249449330716 2.1220174405349e-10 5.29688199579673e-09 UP ENSG00000121104 FAM117A family with sequence similarity 117 member A [Source:HGNC Symbol;Acc:HGNC:24179] - - - - - - 17:49710332-49789180 33 40 64 158 200 269 0.37698755954664 0.415292649089596 0.659183112254875 1.61722450271635 1.8746200065992 2.88002616967362 0.483821106963704 2.12395689299639 -2.13420887188794 2.13348970666431e-10 5.3210694822687e-09 DOWN ENSG00000211456 SACM1L SAC1 suppressor of actin mutations 1-like (yeast) [Source:HGNC Symbol;Acc:HGNC:17059] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0044255|GO:0098797|GO:0016788|GO:0044281|GO:0019637|GO:0005887|GO:0043231|GO:0031227|GO:0005737|GO:0043235|GO:0031226|GO:0030176|GO:1902495|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0031301|GO:0005794|GO:0008328|GO:0008654|GO:0046486|GO:0034702|GO:0006796|GO:0008610|GO:0000139|GO:0030258|GO:0042578|GO:0006644|GO:0016311|GO:0046839|GO:0046474|GO:0032281|GO:0016791|GO:0006650|GO:0046488|GO:0006661|GO:0046856|GO:0052866|GO:0034593|GO:0004438|GO:0043812 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|cellular lipid metabolic process|plasma membrane protein complex|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cytoplasm|receptor complex|intrinsic component of plasma membrane|integral component of endoplasmic reticulum membrane|transmembrane transporter complex|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|integral component of organelle membrane|Golgi apparatus|ionotropic glutamate receptor complex|phospholipid biosynthetic process|glycerolipid metabolic process|ion channel complex|phosphate-containing compound metabolic process|lipid biosynthetic process|Golgi membrane|lipid modification|phosphoric ester hydrolase activity|phospholipid metabolic process|dephosphorylation|phospholipid dephosphorylation|glycerophospholipid biosynthetic process|AMPA glutamate receptor complex|phosphatase activity|glycerophospholipid metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|phosphatidylinositol dephosphorylation|phosphatidylinositol phosphate phosphatase activity|phosphatidylinositol bisphosphate phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity - - - - 3:45689056-45745424 271 300 340 855 863 743 1.33437909520833 1.3424885579647 1.50939744480389 3.77201737503831 3.4864920133296 3.42868678057079 1.39542169932564 3.56239872297957 -1.35214782635478 2.14725683019756e-10 5.35093534296476e-09 DOWN ENSG00000175213 ZNF408 zinc finger protein 408 [Source:HGNC Symbol;Acc:HGNC:20041] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 11:46700818-46705912 990 895 669 320 358 313 15.5413835120238 12.7690249966136 9.46880058543379 4.50092488545375 4.61111513259264 4.60498167398816 12.5930696980237 4.57234056401152 1.46162522890042 2.1692391957188e-10 5.40120658456957e-09 UP ENSG00000123124 WWP1 WW domain containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:17004] GO:0040011|GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0071944|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0016032|GO:0006725|GO:0006810|GO:1901360|GO:0007275|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0009890|GO:0006139|GO:0007154|GO:0055085|GO:0007165|GO:0070062|GO:0019787|GO:0000151|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0051701|GO:0005829|GO:0010468|GO:0034645|GO:0043412|GO:0030163|GO:0007417|GO:0010629|GO:0004842|GO:0051252|GO:0044265|GO:0036211|GO:0006811|GO:1990234|GO:0006508|GO:0044267|GO:0010467|GO:0007399|GO:0019058|GO:0009059|GO:0016070|GO:0005634|GO:0034220|GO:0044257|GO:0061630|GO:0010498|GO:0045892|GO:0046718|GO:0032774|GO:2001141|GO:1902679|GO:0051603|GO:0030260|GO:0006464|GO:0006351|GO:0006355|GO:1903507|GO:0019941|GO:1903506|GO:0043161|GO:0032446|GO:0006511|GO:0042787|GO:0016567 locomotion|developmental process|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|biosynthetic process|ligase activity|intracellular|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|transmembrane transport|signal transduction|extracellular exosome|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|interaction with host|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|protein catabolic process|central nervous system development|negative regulation of gene expression|ubiquitin-protein transferase activity|regulation of RNA metabolic process|cellular macromolecule catabolic process|protein modification process|ion transport|transferase complex|proteolysis|cellular protein metabolic process|gene expression|nervous system development|viral life cycle|macromolecule biosynthetic process|RNA metabolic process|nucleus|ion transmembrane transport|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|negative regulation of transcription, DNA-templated|viral entry into host cell|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|proteolysis involved in cellular protein catabolic process|entry into host cell|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination K05633 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1)[2.3.2.26] hsa04144|hsa04120 Endocytosis - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human) 8:86342738-86478420 578 648 972 1939 1955 2505 4.94089679172899 5.03422750411514 7.49131898251551 14.8509169280937 13.7117357861339 20.0684791697043 5.82214775945321 16.210377294644 -1.47729431081679 2.17106502033882e-10 5.40124792643293e-09 DOWN ENSG00000144320 KIAA1715 KIAA1715 [Source:HGNC Symbol;Acc:HGNC:21610] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0043167|GO:0009653|GO:0016043|GO:0043227|GO:0031224|GO:0050793|GO:0005622|GO:0005789|GO:0012505|GO:0048856|GO:0031090|GO:0050817|GO:0045595|GO:0009888|GO:0007275|GO:0048513|GO:0043231|GO:0043169|GO:0005737|GO:0009611|GO:0048598|GO:0005783|GO:0048869|GO:0016021|GO:0010256|GO:0050878|GO:0006996|GO:0051216|GO:0046872|GO:0042733|GO:0007596|GO:0009790|GO:0042060|GO:0032330|GO:0007599|GO:0035108|GO:0071782|GO:0007029|GO:0030154|GO:0001501|GO:0061448|GO:0060173|GO:0061035|GO:0071786|GO:0002062|GO:0035136|GO:0030326|GO:0035115 developmental process|cell|membrane|cellular process|response to stimulus|binding|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|regulation of developmental process|intracellular|endoplasmic reticulum membrane|endomembrane system|anatomical structure development|organelle membrane|coagulation|regulation of cell differentiation|tissue development|multicellular organism development|animal organ development|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to wounding|embryonic morphogenesis|endoplasmic reticulum|cellular developmental process|integral component of membrane|endomembrane system organization|regulation of body fluid levels|organelle organization|cartilage development|metal ion binding|embryonic digit morphogenesis|blood coagulation|embryo development|wound healing|regulation of chondrocyte differentiation|hemostasis|limb morphogenesis|endoplasmic reticulum tubular network|endoplasmic reticulum organization|cell differentiation|skeletal system development|connective tissue development|limb development|regulation of cartilage development|endoplasmic reticulum tubular network organization|chondrocyte differentiation|forelimb morphogenesis|embryonic limb morphogenesis|embryonic forelimb morphogenesis - - - - 2:175923892-176002839 230 315 550 1066 1313 1146 0.865948922105378 1.07784386733898 1.86698925490952 3.5960017363877 4.05599963459434 4.04369725165899 1.27026068145129 3.89856620754701 -1.61781903974675 2.22417609459053e-10 5.52877211722779e-09 DOWN ENSG00000276975 HYDIN2 HYDIN2, axonemal central pair apparatus protein (pseudogene) [Source:HGNC Symbol;Acc:HGNC:33129] - - - - - - 1:146547367-146914294 10 8 15 51 78 71 0.0477155713357832 0.034693633070194 0.0645330144207929 0.218046904049548 0.305380169031015 0.317515654062412 0.0489807396089234 0.280314242380992 -2.51675858371586 2.26242769753032e-10 5.61917774393264e-09 DOWN ENSG00000131941 RHPN2 rhophilin, Rho GTPase binding protein 2 [Source:HGNC Symbol;Acc:HGNC:19974] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0005829|GO:0031981|GO:0048471|GO:0005654|GO:0035556|GO:0005634|GO:0007264 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|cytosol|nuclear lumen|perinuclear region of cytoplasm|nucleoplasm|intracellular signal transduction|nucleus|small GTPase mediated signal transduction - - - - 19:32978593-33064888 1588 1776 3306 631 729 955 16.0334188662074 16.2966557509362 30.094885317746 5.70824142925403 6.03908689772022 9.03666217934859 20.8083199782965 6.92799683544095 1.58665031330758 2.26450440739858e-10 5.61966039721341e-09 UP ENSG00000154429 CCSAP centriole, cilia and spindle-associated protein [Source:HGNC Symbol;Acc:HGNC:29578] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0042995|GO:0050794|GO:0040012|GO:0043229|GO:0048870|GO:0050793|GO:0005622|GO:0048856|GO:0005929|GO:0001539|GO:0005930|GO:0007275|GO:0005737|GO:0032886|GO:0006928|GO:0043005|GO:0072372|GO:0036064|GO:0051270|GO:0035869|GO:0060296|GO:2000145|GO:0007017|GO:0060294|GO:0005813|GO:0060285|GO:0030424|GO:0005815|GO:0009790|GO:0005814|GO:0060632|GO:0007018|GO:0005856|GO:0005819|GO:0031513|GO:0045995|GO:0015630|GO:0003341|GO:0003356 locomotion|developmental process|cell|cellular process|cell projection|regulation of cellular process|regulation of locomotion|intracellular organelle|cell motility|regulation of developmental process|intracellular|anatomical structure development|cilium|cilium or flagellum-dependent cell motility|axoneme|multicellular organism development|cytoplasm|regulation of microtubule-based process|movement of cell or subcellular component|neuron projection|primary cilium|ciliary basal body|regulation of cellular component movement|ciliary transition zone|regulation of cilium beat frequency involved in ciliary motility|regulation of cell motility|microtubule-based process|cilium movement involved in cell motility|centrosome|cilium-dependent cell motility|axon|microtubule organizing center|embryo development|centriole|regulation of microtubule-based movement|microtubule-based movement|cytoskeleton|spindle|nonmotile primary cilium|regulation of embryonic development|microtubule cytoskeleton|cilium movement|regulation of cilium beat frequency - - - - 1:229321005-229343294 1148 1301 1585 584 720 555 4.73559057257876 4.87741260081893 5.89489012449372 2.15845577772117 2.43687346877563 2.14562880745043 5.1692977659638 2.24698601798241 1.20197716065291 2.27410412576421e-10 5.63879606067814e-09 UP ENSG00000168904 LRRC28 leucine rich repeat containing 28 [Source:HGNC Symbol;Acc:HGNC:28355] GO:0005488|GO:0005515 binding|protein binding - - - - 15:99251362-99390729 17 32 46 131 156 148 0.0806724607938585 0.138011114083605 0.196814949919166 0.556997394307067 0.607404358834057 0.65822414468396 0.138499508265543 0.607541965941695 -2.13310321219514 2.33207877968567e-10 5.77774936835984e-09 DOWN ENSG00000169410 PTPN9 protein tyrosine phosphatase, non-receptor type 9 [Source:HGNC Symbol;Acc:HGNC:9661] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0044237|GO:0016787|GO:0005622|GO:0005515|GO:0016788|GO:0005737|GO:0019538|GO:0043412|GO:0036211|GO:0006796|GO:0044267|GO:0042578|GO:0016311|GO:0016791|GO:0006464|GO:0006470|GO:0004721|GO:0035335|GO:0004725|GO:0004726 cell|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|cellular metabolic process|hydrolase activity|intracellular|protein binding|hydrolase activity, acting on ester bonds|cytoplasm|protein metabolic process|macromolecule modification|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|phosphoric ester hydrolase activity|dephosphorylation|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity|non-membrane spanning protein tyrosine phosphatase activity - - - - 15:75463251-75579289 209 199 290 666 757 610 1.26046639919259 1.09073267443027 1.57687508232337 3.59879250025466 3.74583644996185 3.44781156845741 1.30935805198208 3.59748017289131 -1.45812707070271 2.33645665770816e-10 5.78379577605467e-09 DOWN ENSG00000106246 PTCD1 pentatricopeptide repeat domain 1 [Source:HGNC Symbol;Acc:HGNC:22198] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0003723|GO:0005759|GO:0005739|GO:0010467|GO:0016070|GO:0000049|GO:0006396|GO:0034660|GO:0044822|GO:0006399|GO:0031123|GO:0008033|GO:0042780 cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|RNA binding|mitochondrial matrix|mitochondrion|gene expression|RNA metabolic process|tRNA binding|RNA processing|ncRNA metabolic process|poly(A) RNA binding|tRNA metabolic process|RNA 3'-end processing|tRNA processing|tRNA 3'-end processing - - - - 7:99416739-99466163 1485 1420 1030 471 516 242 14.7451166700967 12.814162079016 9.22089529750389 4.19025656169742 4.20377912606158 2.25199261189913 12.2600580155389 3.54867609988604 1.7886130003047 2.35196045897178e-10 5.81735108054212e-09 UP ENSG00000257027 RP11-705C15.3 - - - - - - - 12:9658567-9662085 16 23 30 96 108 100 0.451277220143357 0.589568729057603 0.762868744636231 2.42598464737639 2.49924117851284 2.64330970445639 0.601238231279064 2.52284517678187 -2.06904301824575 2.44654217588273e-10 6.04628063897377e-09 DOWN ENSG00000088367 EPB41L1 erythrocyte membrane protein band 4.1-like 1 [Source:HGNC Symbol;Acc:HGNC:3378] GO:0040007|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0019898|GO:0050794|GO:0043229|GO:0016049|GO:0051641|GO:0005911|GO:0016043|GO:0071944|GO:0040008|GO:0005622|GO:0005515|GO:0005886|GO:0051128|GO:0051651|GO:0005737|GO:0007267|GO:0008104|GO:0007154|GO:0008092|GO:0030029|GO:0001558|GO:0006996|GO:0005829|GO:0007010|GO:0003779|GO:0007016|GO:0032507|GO:0030036|GO:0034613|GO:0005856|GO:0030866|GO:0030865|GO:0007268 growth|structural molecule activity|signaling|cell|membrane|cellular process|cell junction|binding|extrinsic component of membrane|regulation of cellular process|intracellular organelle|cell growth|cellular localization|cell-cell junction|cellular component organization|cell periphery|regulation of growth|intracellular|protein binding|plasma membrane|regulation of cellular component organization|maintenance of location in cell|cytoplasm|cell-cell signaling|protein localization|cell communication|cytoskeletal protein binding|actin filament-based process|regulation of cell growth|organelle organization|cytosol|cytoskeleton organization|actin binding|cytoskeletal anchoring at plasma membrane|maintenance of protein location in cell|actin cytoskeleton organization|cellular protein localization|cytoskeleton|cortical actin cytoskeleton organization|cortical cytoskeleton organization|synaptic transmission K06107 erythrocyte membrane protein band 4.1[-] hsa04530 Tight junction - Homo sapiens (human) 20:36091504-36232799 571 551 949 1843 2055 2012 3.13934034513025 2.7531737813015 4.70416623337232 9.07873216884467 9.27004796911934 10.3671461749234 3.53222678660136 9.57197543762914 -1.43823872063566 2.48122320005701e-10 6.12185433177703e-09 DOWN ENSG00000178177 LCORL ligand dependent nuclear receptor corepressor like [Source:HGNC Symbol;Acc:HGNC:30776] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 4:17841199-18021876 64 57 33 215 257 289 0.293894236012027 0.237886694570555 0.136629598916819 0.884601559587063 0.968306804690145 1.24376642324553 0.222803509833134 1.03222492917425 -2.21191351375174 2.47975280923042e-10 6.12185433177703e-09 DOWN ENSG00000133874 RNF122 ring finger protein 122 [Source:HGNC Symbol;Acc:HGNC:21147] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0043231|GO:0043169|GO:0005737|GO:0005783|GO:0019787|GO:0016021|GO:0019538|GO:0005794|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:0006508|GO:0044267|GO:0044257|GO:0061630|GO:0010498|GO:0051603|GO:0046914|GO:0006464|GO:0019941|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0042787|GO:0016567|GO:0000209 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|intracellular membrane-bounded organelle|cation binding|cytoplasm|endoplasmic reticulum|ubiquitin-like protein transferase activity|integral component of membrane|protein metabolic process|Golgi apparatus|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|proteolysis|cellular protein metabolic process|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|proteolysis involved in cellular protein catabolic process|transition metal ion binding|cellular protein modification process|modification-dependent protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 8:33547755-33567125 81 84 139 23 30 26 3.06730019971703 2.89086369092175 4.74567216718688 0.780368067907482 0.932088463594454 0.92271998397852 3.56794535260855 0.878392171826819 2.02215641650094 2.48706525948286e-10 6.13120117725857e-09 UP ENSG00000058335 RASGRF1 Ras protein specific guanine nucleotide releasing factor 1 [Source:HGNC Symbol;Acc:HGNC:9875] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0008283|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0030427|GO:0044708|GO:0071944|GO:0009605|GO:0009893|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0005085|GO:0048856|GO:0019222|GO:0050804|GO:0006935|GO:0045087|GO:0048468|GO:0006810|GO:0007275|GO:0050877|GO:0005102|GO:0006952|GO:0031325|GO:0030426|GO:0050803|GO:0010243|GO:0005737|GO:0007267|GO:0005088|GO:0006928|GO:0043005|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0055085|GO:0007165|GO:0009725|GO:0007611|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0010469|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0048167|GO:0007166|GO:0043412|GO:0051345|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0007613|GO:0006811|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0034765|GO:0002764|GO:0043269|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0050890|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:0005089|GO:1902531|GO:0032870|GO:0035254|GO:0022898|GO:0034220|GO:0048666|GO:0030182|GO:0007411|GO:2000310|GO:0031401|GO:0007215|GO:0008543|GO:0048168|GO:1901653|GO:0043408|GO:0071363|GO:0043087|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0032412|GO:0043547|GO:0007167|GO:0071375|GO:0043410|GO:0007616|GO:0032868|GO:0051057|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0090630|GO:0007409|GO:0006468|GO:0048699|GO:0046579|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0042327|GO:0007268|GO:0007169|GO:0048010|GO:0038095|GO:0016601|GO:0035023|GO:0071900|GO:0007266|GO:0035020|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|cell proliferation|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|site of polarized growth|single-organism behavior|cell periphery|response to external stimulus|positive regulation of metabolic process|intracellular|regulation of immune system process|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|modulation of synaptic transmission|chemotaxis|innate immune response|cell development|transport|multicellular organism development|neurological system process|receptor binding|defense response|positive regulation of cellular metabolic process|growth cone|regulation of synapse structure or activity|response to organonitrogen compound|cytoplasm|cell-cell signaling|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|neuron projection|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|transmembrane transport|signal transduction|response to hormone|learning or memory|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|regulation of receptor activity|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|regulation of synaptic plasticity|cell surface receptor signaling pathway|macromolecule modification|positive regulation of hydrolase activity|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|memory|ion transport|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|regulation of ion transmembrane transport|immune response-regulating signaling pathway|regulation of ion transport|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|cognition|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|regulation of intracellular signal transduction|cellular response to hormone stimulus|glutamate receptor binding|regulation of transmembrane transporter activity|ion transmembrane transport|neuron development|neuron differentiation|axon guidance|regulation of N-methyl-D-aspartate selective glutamate receptor activity|positive regulation of protein modification process|glutamate receptor signaling pathway|fibroblast growth factor receptor signaling pathway|regulation of neuronal synaptic plasticity|cellular response to peptide|regulation of MAPK cascade|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|regulation of ion transmembrane transporter activity|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|long-term memory|response to insulin|positive regulation of small GTPase mediated signal transduction|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|activation of GTPase activity|axonogenesis|protein phosphorylation|generation of neurons|positive regulation of Ras protein signal transduction|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|Rac protein signal transduction|regulation of Rho protein signal transduction|regulation of protein serine/threonine kinase activity|Rho protein signal transduction|regulation of Rac protein signal transduction|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K04349 Ras-specific guanine nucleotide-releasing factor 1[-] hsa04010|hsa04014|hsa04510 MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human) 15:78959947-79090773 9 11 10 51 61 66 0.0524238469209432 0.0582337572074798 0.0525181587588221 0.266166609488678 0.291530445287651 0.360295069905518 0.054391920962415 0.305997374893949 -2.49205499275002 2.49426587050493e-10 6.14387898498796e-09 DOWN ENSG00000158545 ZC3H18 zinc finger CCCH-type containing 18 [Source:HGNC Symbol;Acc:HGNC:25091] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0043169|GO:0046872|GO:0003723|GO:0031981|GO:0005654|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|metal ion binding|RNA binding|nuclear lumen|nucleoplasm|nucleus|poly(A) RNA binding - - - - 16:88570381-88631966 390 507 481 1246 1544 1046 1.98384499552808 2.34385823232749 2.20598845134124 5.67883283354021 6.44404678353593 4.98659306956656 2.17789722639894 5.70315756221423 -1.38882501507836 2.50134877015249e-10 6.15624618170920e-09 DOWN ENSG00000146530 VWDE von Willebrand factor D and EGF domains [Source:HGNC Symbol;Acc:HGNC:21897] GO:0005576|GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0005509 extracellular region|binding|ion binding|protein binding|cation binding|metal ion binding|calcium ion binding - - - - 7:12330885-12403941 37 32 44 129 161 174 0.338188554142067 0.265821639298388 0.362600793319764 1.05644675724609 1.20741300788272 1.49052856279641 0.322203662253406 1.25146277597507 -1.95757058223833 2.51030548478558e-10 6.17320098375525e-09 DOWN ENSG00000206530 CFAP44 cilia and flagella associated protein 44 [Source:HGNC Symbol;Acc:HGNC:25631] GO:0005623|GO:0005488|GO:0042995|GO:0005515 cell|binding|cell projection|protein binding - - - - 3:113286930-113441610 122 158 205 461 493 581 0.389541042040694 0.458490282950843 0.590147763084802 1.31883990337926 1.29154064059596 1.73859726100171 0.47939302935878 1.44965926832564 -1.59643300863648 2.53931432696314e-10 6.23939834709115e-09 DOWN ENSG00000114861 FOXP1 forkhead box P1 [Source:HGNC Symbol;Acc:HGNC:3823] GO:0040011|GO:0032502|GO:0040007|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0040008|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0007507|GO:0060341|GO:0008284|GO:0051272|GO:0042127|GO:1903706|GO:0016337|GO:0002286|GO:0006935|GO:0045595|GO:0016445|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:1901360|GO:0010941|GO:0007275|GO:0010632|GO:0030324|GO:0003676|GO:0045596|GO:0048513|GO:0070489|GO:0005102|GO:0034641|GO:0046620|GO:0032940|GO:0006952|GO:0021517|GO:0031325|GO:0046483|GO:2000147|GO:0022607|GO:0098542|GO:0001817|GO:0035265|GO:0098609|GO:0061061|GO:0055017|GO:0045597|GO:0043231|GO:0043169|GO:0000981|GO:0001816|GO:0002377|GO:0009611|GO:0032880|GO:0006928|GO:0001775|GO:0009966|GO:0048729|GO:0046983|GO:0002263|GO:0050673|GO:0045184|GO:1900424|GO:0009890|GO:0003682|GO:0030323|GO:0060548|GO:0010646|GO:0006139|GO:0009617|GO:0008104|GO:0046649|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0002366|GO:0009968|GO:0048638|GO:1901863|GO:0009725|GO:1901250|GO:0008219|GO:0010634|GO:0060348|GO:0030030|GO:0048869|GO:0030029|GO:2000145|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0002292|GO:0006996|GO:0072089|GO:0050679|GO:0000902|GO:0060043|GO:0031175|GO:0060479|GO:0003677|GO:1901509|GO:0051149|GO:0042113|GO:0042117|GO:0010468|GO:0090132|GO:0034645|GO:0048660|GO:0046872|GO:0002009|GO:0033993|GO:0007010|GO:0030097|GO:0072358|GO:0030098|GO:0007417|GO:0010629|GO:0050727|GO:0002237|GO:0051427|GO:0016447|GO:0042692|GO:0043069|GO:0046982|GO:0051252|GO:0060541|GO:0021510|GO:0035051|GO:0048738|GO:0010463|GO:0051223|GO:0032655|GO:0060420|GO:0015031|GO:0048659|GO:0000904|GO:0009790|GO:0010628|GO:0045844|GO:0030334|GO:0051147|GO:0001667|GO:0033151|GO:0048661|GO:0032615|GO:0030856|GO:0070201|GO:0060537|GO:0003705|GO:0006954|GO:0032602|GO:0051046|GO:0031981|GO:0007159|GO:0009306|GO:0005654|GO:0060433|GO:0006259|GO:0033143|GO:0050678|GO:0055001|GO:0042116|GO:0033144|GO:0030036|GO:0060038|GO:0050663|GO:0070925|GO:0042110|GO:0012501|GO:0014070|GO:0060429|GO:1901256|GO:0002639|GO:0010467|GO:0032990|GO:0007399|GO:0060562|GO:0046903|GO:0071310|GO:0097485|GO:0010594|GO:0002637|GO:0031328|GO:0042742|GO:0009059|GO:0030154|GO:0009755|GO:0001501|GO:0048858|GO:0030239|GO:0030335|GO:0042093|GO:0007517|GO:0050707|GO:0042118|GO:0016070|GO:0072359|GO:0032870|GO:0060428|GO:0010557|GO:0030857|GO:0032496|GO:0005634|GO:0042803|GO:0043067|GO:0048545|GO:2000648|GO:0030522|GO:0010595|GO:0045637|GO:0032652|GO:0072091|GO:0016202|GO:0048666|GO:0030182|GO:0043401|GO:0032680|GO:0055002|GO:0002521|GO:0060481|GO:0003158|GO:0007411|GO:0002761|GO:0060538|GO:0000975|GO:0055024|GO:0072610|GO:0051153|GO:0045893|GO:0009792|GO:0032651|GO:0030855|GO:0030183|GO:0045892|GO:0060487|GO:0032774|GO:0043565|GO:0060482|GO:2001141|GO:0035257|GO:0030217|GO:0050708|GO:1902679|GO:0060766|GO:0071383|GO:0033152|GO:0032640|GO:0071407|GO:0036035|GO:0070486|GO:0032611|GO:0003690|GO:0046631|GO:0061564|GO:0030518|GO:0090195|GO:0002053|GO:1901249|GO:0061154|GO:0072619|GO:0006310|GO:0051146|GO:0010631|GO:0042981|GO:0043066|GO:0060765|GO:0048745|GO:0050701|GO:0030099|GO:0031032|GO:0061470|GO:0014706|GO:0022008|GO:0048667|GO:0055007|GO:0045214|GO:0048812|GO:2001182|GO:0071396|GO:0051155|GO:0006351|GO:0006915|GO:0006355|GO:0010464|GO:2000107|GO:0045944|GO:0006366|GO:0002573|GO:1903507|GO:0002327|GO:0035258|GO:0050706|GO:0006357|GO:0007409|GO:0046632|GO:0008045|GO:0048699|GO:0007519|GO:1903506|GO:0044212|GO:0035926|GO:0045655|GO:0061140|GO:0016444|GO:0060480|GO:0030521|GO:2000727|GO:0043009|GO:0050702|GO:0035710|GO:0000122|GO:0043542|GO:0071593|GO:0050681|GO:0002067|GO:0002329|GO:0030224|GO:0000976|GO:0001012|GO:0030316|GO:0001701|GO:0001159|GO:0043367|GO:0070228|GO:0002902|GO:0000977|GO:0000987|GO:0002903|GO:0001783|GO:0000978 locomotion|developmental process|growth|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|regulation of growth|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|heart development|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|regulation of hemopoiesis|single organismal cell-cell adhesion|T cell activation involved in immune response|chemotaxis|regulation of cell differentiation|somatic diversification of immunoglobulins|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|transport|tube development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|lung development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|T cell aggregation|receptor binding|cellular nitrogen compound metabolic process|regulation of organ growth|secretion by cell|defense response|ventral spinal cord development|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell motility|cellular component assembly|defense response to other organism|regulation of cytokine production|organ growth|cell-cell adhesion|muscle structure development|cardiac muscle tissue growth|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cytokine production|immunoglobulin production|response to wounding|regulation of protein localization|movement of cell or subcellular component|cell activation|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|cell activation involved in immune response|epithelial cell proliferation|establishment of protein localization|regulation of defense response to bacterium|negative regulation of biosynthetic process|chromatin binding|respiratory tube development|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|protein localization|lymphocyte activation|cell communication|regulation of cellular component movement|cell migration|signal transduction|leukocyte activation involved in immune response|negative regulation of signal transduction|regulation of developmental growth|positive regulation of muscle tissue development|response to hormone|negative regulation of lung goblet cell differentiation|cell death|positive regulation of epithelial cell migration|bone development|cell projection organization|cellular developmental process|actin filament-based process|regulation of cell motility|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|T cell differentiation involved in immune response|organelle organization|stem cell proliferation|positive regulation of epithelial cell proliferation|cell morphogenesis|regulation of cardiac muscle cell proliferation|neuron projection development|lung cell differentiation|DNA binding|regulation of endothelial tube morphogenesis|positive regulation of muscle cell differentiation|B cell activation|monocyte activation|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|metal ion binding|morphogenesis of an epithelium|response to lipid|cytoskeleton organization|hemopoiesis|cardiovascular system development|lymphocyte differentiation|central nervous system development|negative regulation of gene expression|regulation of inflammatory response|response to molecule of bacterial origin|hormone receptor binding|somatic recombination of immunoglobulin gene segments|muscle cell differentiation|negative regulation of programmed cell death|protein heterodimerization activity|regulation of RNA metabolic process|respiratory system development|spinal cord development|cardiocyte differentiation|cardiac muscle tissue development|mesenchymal cell proliferation|regulation of protein transport|regulation of interleukin-12 production|regulation of heart growth|protein transport|smooth muscle cell proliferation|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|positive regulation of striated muscle tissue development|regulation of cell migration|regulation of muscle cell differentiation|ameboidal-type cell migration|V(D)J recombination|positive regulation of smooth muscle cell proliferation|interleukin-12 production|regulation of epithelial cell differentiation|regulation of establishment of protein localization|muscle tissue development|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|inflammatory response|chemokine production|regulation of secretion|nuclear lumen|leukocyte cell-cell adhesion|protein secretion|nucleoplasm|bronchus development|DNA metabolic process|regulation of intracellular steroid hormone receptor signaling pathway|regulation of epithelial cell proliferation|muscle cell development|macrophage activation|negative regulation of intracellular steroid hormone receptor signaling pathway|actin cytoskeleton organization|cardiac muscle cell proliferation|cytokine secretion|organelle assembly|T cell activation|programmed cell death|response to organic cyclic compound|epithelium development|regulation of macrophage colony-stimulating factor production|positive regulation of immunoglobulin production|gene expression|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|secretion|cellular response to organic substance|neuron projection guidance|regulation of endothelial cell migration|regulation of immunoglobulin production|positive regulation of cellular biosynthetic process|defense response to bacterium|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|skeletal system development|cell projection morphogenesis|myofibril assembly|positive regulation of cell migration|T-helper cell differentiation|muscle organ development|regulation of cytokine secretion|endothelial cell activation|RNA metabolic process|circulatory system development|cellular response to hormone stimulus|lung epithelium development|positive regulation of macromolecule biosynthetic process|negative regulation of epithelial cell differentiation|response to lipopolysaccharide|nucleus|protein homodimerization activity|regulation of programmed cell death|response to steroid hormone|positive regulation of stem cell proliferation|intracellular receptor signaling pathway|positive regulation of endothelial cell migration|regulation of myeloid cell differentiation|regulation of interleukin-1 production|regulation of stem cell proliferation|regulation of striated muscle tissue development|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|regulation of tumor necrosis factor production|striated muscle cell development|leukocyte differentiation|lobar bronchus epithelium development|endothelium development|axon guidance|regulation of myeloid leukocyte differentiation|skeletal muscle organ development|regulatory region DNA binding|regulation of cardiac muscle tissue development|interleukin-12 secretion|regulation of striated muscle cell differentiation|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|regulation of interleukin-1 beta production|epithelial cell differentiation|B cell differentiation|negative regulation of transcription, DNA-templated|lung epithelial cell differentiation|RNA biosynthetic process|sequence-specific DNA binding|lobar bronchus development|regulation of RNA biosynthetic process|nuclear hormone receptor binding|T cell differentiation|regulation of protein secretion|negative regulation of RNA biosynthetic process|negative regulation of androgen receptor signaling pathway|cellular response to steroid hormone stimulus|immunoglobulin V(D)J recombination|tumor necrosis factor production|cellular response to organic cyclic compound|osteoclast development|leukocyte aggregation|interleukin-1 beta production|double-stranded DNA binding|alpha-beta T cell activation|axon development|intracellular steroid hormone receptor signaling pathway|chemokine secretion|positive regulation of mesenchymal cell proliferation|regulation of lung goblet cell differentiation|endothelial tube morphogenesis|interleukin-21 secretion|DNA recombination|striated muscle cell differentiation|epithelial cell migration|regulation of apoptotic process|negative regulation of apoptotic process|regulation of androgen receptor signaling pathway|smooth muscle tissue development|interleukin-1 secretion|myeloid cell differentiation|actomyosin structure organization|T follicular helper cell differentiation|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|cardiac muscle cell differentiation|sarcomere organization|neuron projection morphogenesis|regulation of interleukin-12 secretion|cellular response to lipid|positive regulation of striated muscle cell differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of mesenchymal cell proliferation|negative regulation of leukocyte apoptotic process|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|myeloid leukocyte differentiation|negative regulation of nucleic acid-templated transcription|immature B cell differentiation|steroid hormone receptor binding|regulation of interleukin-1 beta secretion|regulation of transcription from RNA polymerase II promoter|axonogenesis|alpha-beta T cell differentiation|motor neuron axon guidance|generation of neurons|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chemokine (C-C motif) ligand 2 secretion|regulation of monocyte differentiation|lung secretory cell differentiation|somatic cell DNA recombination|lung goblet cell differentiation|androgen receptor signaling pathway|positive regulation of cardiac muscle cell differentiation|chordate embryonic development|interleukin-1 beta secretion|CD4-positive, alpha-beta T cell activation|negative regulation of transcription from RNA polymerase II promoter|endothelial cell migration|lymphocyte aggregation|androgen receptor binding|glandular epithelial cell differentiation|pre-B cell differentiation|monocyte differentiation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|osteoclast differentiation|in utero embryonic development|core promoter proximal region DNA binding|CD4-positive, alpha-beta T cell differentiation|regulation of lymphocyte apoptotic process|regulation of B cell apoptotic process|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|negative regulation of B cell apoptotic process|B cell apoptotic process|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - hsa05206 MicroRNAs in cancer - Homo sapiens (human) 3:70954693-71583989 16 20 70 214 260 245 0.0488562232633833 0.0555014262963563 0.192710443885974 0.585472400517064 0.651382611622685 0.7011159718252 0.0990226978152379 0.645990327988316 -2.7056814041776 2.58670337336684e-10 6.35061204839585e-09 DOWN ENSG00000104983 CCDC61 coiled-coil domain containing 61 [Source:HGNC Symbol;Acc:HGNC:33629] GO:0005623|GO:0043229|GO:0005622|GO:0005813|GO:0005815|GO:0005856|GO:0015630 cell|intracellular organelle|intracellular|centrosome|microtubule organizing center|cytoskeleton|microtubule cytoskeleton - - - - 19:45995461-46021318 26 40 48 152 158 142 0.475967623602792 0.665500021522458 0.792256663428704 2.49315968042926 2.37319816423401 2.43627707774141 0.644574769517985 2.43421164080156 -1.91703498415467 2.60857307493945e-10 6.38854311560643e-09 DOWN ENSG00000143641 GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:4124] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0031228|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0002377|GO:0005975|GO:0070062|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0002378|GO:0008194|GO:0030173|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0048471|GO:0070085|GO:0005795|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0018242|GO:0031985|GO:0032580|GO:0046914|GO:0018243|GO:0008376|GO:0006464|GO:0016266|GO:0004653|GO:0030145|GO:0018193|GO:0043687 immune system process|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|protein glycosylation|intrinsic component of Golgi membrane|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|immunoglobulin production|carbohydrate metabolic process|extracellular exosome|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|immunoglobulin biosynthetic process|UDP-glycosyltransferase activity|integral component of Golgi membrane|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|perinuclear region of cytoplasm|glycosylation|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|protein O-linked glycosylation via serine|Golgi cisterna|Golgi cisterna membrane|transition metal ion binding|protein O-linked glycosylation via threonine|acetylgalactosaminyltransferase activity|cellular protein modification process|O-glycan processing|polypeptide N-acetylgalactosaminyltransferase activity|manganese ion binding|peptidyl-amino acid modification|post-translational protein modification K00710 polypeptide N-acetylgalactosaminyltransferase[2.4.1.41] hsa01100|hsa00512 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human) 1:230057990-230282124 1132 1373 2547 5069 5551 5292 6.902344959095 7.60853004297354 14.0021084316151 27.6930211141553 27.7708725051929 30.2412065776989 9.50432781122788 28.568366732349 -1.58776205732495 2.60757634142143e-10 6.38854311560643e-09 DOWN ENSG00000156011 PSD3 pleckstrin and Sec7 domain containing 3 [Source:HGNC Symbol;Acc:HGNC:19093] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0060076|GO:0043229|GO:0043167|GO:0023051|GO:0008289|GO:0071944|GO:0009893|GO:0005622|GO:0005886|GO:0005085|GO:0097060|GO:0019222|GO:0043168|GO:0005543|GO:0045211|GO:0009966|GO:0014069|GO:0010646|GO:0005086|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0051345|GO:0035556|GO:1902531|GO:0043087|GO:0043547|GO:0051056|GO:0007264|GO:0007265|GO:0046578|GO:0032012 synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|excitatory synapse|intracellular organelle|ion binding|regulation of signaling|lipid binding|cell periphery|positive regulation of metabolic process|intracellular|plasma membrane|guanyl-nucleotide exchange factor activity|synaptic membrane|regulation of metabolic process|anion binding|phospholipid binding|postsynaptic membrane|regulation of signal transduction|postsynaptic density|regulation of cell communication|ARF guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|positive regulation of hydrolase activity|intracellular signal transduction|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of ARF protein signal transduction K12494 PH and SEC7 domain-containing protein[-] hsa04144 Endocytosis - Homo sapiens (human) 8:18527301-19084730 131 175 355 728 834 987 0.214716672669033 0.260683279386775 0.524611096643106 1.06911328082783 1.12157490371745 1.51614526374875 0.333337016232971 1.23561114943134 -1.8901713550781 2.6068352943143e-10 6.38854311560643e-09 DOWN ENSG00000234129 RP11-120D5.1 - - - - - - - X:10847877-11111141 1 3 1 22 35 26 0.0181639356834224 0.0495103518724534 0.0163615702823009 0.357883634275749 0.521391464378423 0.442412969730974 0.0280119526127256 0.440562689461715 -3.97523286358741 2.6156187491728e-10 6.40054771621349e-09 DOWN ENSG00000159685 CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 [Source:HGNC Symbol;Acc:HGNC:28184] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0043229|GO:0006950|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0019866|GO:0033554|GO:0043231|GO:0005737|GO:0031966|GO:0061024|GO:0016021|GO:0031301|GO:0006996|GO:0005740|GO:0061617|GO:0007005|GO:0005743|GO:0031304|GO:0005739|GO:0032592|GO:0006974|GO:0007006|GO:0007007|GO:0031305|GO:0042407 macromolecular complex|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|intracellular organelle|response to stress|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|organelle membrane|organelle inner membrane|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|membrane organization|integral component of membrane|integral component of organelle membrane|organelle organization|mitochondrial envelope|MICOS complex|mitochondrion organization|mitochondrial inner membrane|intrinsic component of mitochondrial inner membrane|mitochondrion|integral component of mitochondrial membrane|cellular response to DNA damage stimulus|mitochondrial membrane organization|inner mitochondrial membrane organization|integral component of mitochondrial inner membrane|cristae formation - - - - 3:126704220-126960406 49 52 131 361 361 333 0.767008240060264 0.739752092965615 1.84879203193879 5.06299763518849 4.63637048628406 4.88513019784151 1.11851745498822 4.86149943977135 -2.11981358462004 2.64103903430416e-10 6.45745940459593e-09 DOWN ENSG00000236449 AC018890.6 - - - - - - - 2:174547141-174774827 6 2 5 42 42 33 0.111537812796055 0.0337909603569353 0.0837994443644411 0.699587829507231 0.640633212683838 0.574957073447123 0.0763760725058105 0.638392705212731 -3.06325152712998 2.68031037087916e-10 6.54811667857826e-09 DOWN ENSG00000214717 ZBED1 zinc finger, BED-type containing 1 [Source:HGNC Symbol;Acc:HGNC:447] GO:0005623|GO:0005488|GO:0003824|GO:0004803|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0043169|GO:0005737|GO:0046983|GO:0003677|GO:0046872|GO:0031981|GO:0005694|GO:0000228|GO:0005856|GO:0005634|GO:0015629 cell|binding|catalytic activity|transposase activity|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein dimerization activity|DNA binding|metal ion binding|nuclear lumen|chromosome|nuclear chromosome|cytoskeleton|nucleus|actin cytoskeleton - - - - X:2486414-2500967 740 1046 1207 272 380 487 3.86940332915075 4.97077016735825 5.69028235390286 1.27432102640085 1.63028493353259 2.3865447555974 4.84348528347062 1.76371690517695 1.45742654618253 2.78955360895619e-10 6.8094303713637e-09 UP ENSG00000204177 BMS1P1 BMS1, ribosome biogenesis factor pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:23649] - - - - - - 10:46786674-46811989 55 93 107 301 289 348 0.827592345143868 1.27180376898773 1.45162405717167 4.05806496350367 3.56796588029381 4.9075368173181 1.18367339043442 4.17785588703853 -1.81949167346797 2.79963363047754e-10 6.82845281080689e-09 DOWN ENSG00000180667 YOD1 YOD1 deubiquitinase [Source:HGNC Symbol;Acc:HGNC:25035] GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0051051|GO:0044237|GO:0051641|GO:1903828|GO:0016787|GO:0005515|GO:0019222|GO:0060341|GO:0006810|GO:0033554|GO:0043169|GO:0008233|GO:0019899|GO:1903573|GO:0032880|GO:0045184|GO:0032387|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0090317|GO:0019538|GO:0010033|GO:0051224|GO:0036503|GO:0036459|GO:0046872|GO:0030968|GO:0061578|GO:0043412|GO:0030163|GO:1990380|GO:0030970|GO:0032386|GO:0051223|GO:0015031|GO:0044265|GO:0036211|GO:0070201|GO:0046907|GO:1904455|GO:0006986|GO:0030433|GO:0006508|GO:0034613|GO:0044267|GO:0042176|GO:1904292|GO:0071310|GO:1904293|GO:0051246|GO:0035967|GO:1903827|GO:0042177|GO:0034976|GO:0044389|GO:1904265|GO:0034620|GO:0031625|GO:0044257|GO:0033157|GO:0010498|GO:0032527|GO:0016482|GO:0006886|GO:1904152|GO:0051603|GO:0070646|GO:0004843|GO:0008234|GO:0006464|GO:1904153|GO:0019941|GO:0016579|GO:0070861|GO:0043161|GO:0006511|GO:0070536|GO:0035523|GO:1990168|GO:1990167|GO:0071108|GO:0035871 signaling|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|catabolic process|ion binding|negative regulation of transport|cellular metabolic process|cellular localization|negative regulation of cellular protein localization|hydrolase activity|protein binding|regulation of metabolic process|regulation of cellular localization|transport|cellular response to stress|cation binding|peptidase activity|enzyme binding|negative regulation of response to endoplasmic reticulum stress|regulation of protein localization|establishment of protein localization|negative regulation of intracellular transport|protein localization|cell communication|signal transduction|establishment of localization in cell|negative regulation of intracellular protein transport|protein metabolic process|response to organic substance|negative regulation of protein transport|ERAD pathway|thiol-dependent ubiquitinyl hydrolase activity|metal ion binding|endoplasmic reticulum unfolded protein response|Lys63-specific deubiquitinase activity|macromolecule modification|protein catabolic process|Lys48-specific deubiquitinase activity|retrograde protein transport, ER to cytosol|regulation of intracellular transport|regulation of protein transport|protein transport|cellular macromolecule catabolic process|protein modification process|regulation of establishment of protein localization|intracellular transport|ubiquitin-specific protease activity involved in negative regulation of ERAD pathway|response to unfolded protein|ER-associated ubiquitin-dependent protein catabolic process|proteolysis|cellular protein localization|cellular protein metabolic process|regulation of protein catabolic process|regulation of ERAD pathway|cellular response to organic substance|negative regulation of ERAD pathway|regulation of protein metabolic process|cellular response to topologically incorrect protein|regulation of cellular protein localization|negative regulation of protein catabolic process|response to endoplasmic reticulum stress|ubiquitin-like protein ligase binding|ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol|cellular response to unfolded protein|ubiquitin protein ligase binding|cellular protein catabolic process|regulation of intracellular protein transport|proteasomal protein catabolic process|protein exit from endoplasmic reticulum|cytosolic transport|intracellular protein transport|regulation of retrograde protein transport, ER to cytosol|proteolysis involved in cellular protein catabolic process|protein modification by small protein removal|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|negative regulation of retrograde protein transport, ER to cytosol|modification-dependent protein catabolic process|protein deubiquitination|regulation of protein exit from endoplasmic reticulum|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|protein K63-linked deubiquitination|protein K29-linked deubiquitination|protein K33-linked deubiquitination|protein K27-linked deubiquitination|protein K48-linked deubiquitination|protein K11-linked deubiquitination K13719 ubiquitin thioesterase OTU1 [EC:3.1.2.-][-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 1:207043849-207052980 2391 3304 4439 1383 1415 1542 25.3153421540947 31.7924787181297 42.3744045981624 13.1197032866925 12.2921737777293 15.3009210329314 33.1607418234623 13.5709326991177 1.28895640376176 2.93097913203499e-10 7.14297559247123e-09 UP ENSG00000102531 FNDC3A fibronectin type III domain containing 3A [Source:HGNC Symbol;Acc:HGNC:20296] GO:0032502|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0005488|GO:0097159|GO:0043229|GO:0044702|GO:0019953|GO:0003006|GO:0007155|GO:0043227|GO:0032504|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0048609|GO:0045137|GO:0016337|GO:0009888|GO:0048468|GO:0007275|GO:0003676|GO:0048513|GO:0031982|GO:0098609|GO:0060009|GO:0030141|GO:0043231|GO:0048608|GO:0005737|GO:0012506|GO:0048515|GO:0007548|GO:0060008|GO:0008406|GO:0007276|GO:0001669|GO:0009566|GO:0048869|GO:0016021|GO:0007281|GO:0005794|GO:0005829|GO:0007286|GO:0008584|GO:0048232|GO:0003723|GO:0046661|GO:0061458|GO:0031410|GO:0002064|GO:0016023|GO:0031988|GO:0060429|GO:0000139|GO:0030154|GO:0046546|GO:0007283|GO:0030855|GO:0044822 developmental process|reproduction|cell|membrane|cellular process|reproductive process|binding|organic cyclic compound binding|intracellular organelle|single organism reproductive process|sexual reproduction|developmental process involved in reproduction|cell adhesion|membrane-bounded organelle|multicellular organism reproduction|intrinsic component of membrane|intracellular|protein binding|endomembrane system|anatomical structure development|organelle membrane|multicellular organismal reproductive process|development of primary sexual characteristics|single organismal cell-cell adhesion|tissue development|cell development|multicellular organism development|nucleic acid binding|animal organ development|vesicle|cell-cell adhesion|Sertoli cell development|secretory granule|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|vesicle membrane|spermatid differentiation|sex differentiation|Sertoli cell differentiation|gonad development|gamete generation|acrosomal vesicle|fertilization|cellular developmental process|integral component of membrane|germ cell development|Golgi apparatus|cytosol|spermatid development|male gonad development|male gamete generation|RNA binding|male sex differentiation|reproductive system development|cytoplasmic vesicle|epithelial cell development|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|epithelium development|Golgi membrane|cell differentiation|development of primary male sexual characteristics|spermatogenesis|epithelial cell differentiation|poly(A) RNA binding - - - - 13:48975912-49209779 497 525 958 1836 2087 1986 2.17712436081781 2.09009561655743 3.78361232675018 7.2060524012394 7.50096895928311 8.15333113944403 2.68361076804181 7.62011749998885 -1.50563780616985 2.96964841224962e-10 7.23131188411909e-09 DOWN ENSG00000166575 TMEM135 transmembrane protein 135 [Source:HGNC Symbol;Acc:HGNC:26167] GO:0005623|GO:0016020|GO:0009987|GO:0043229|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0043231|GO:0005737|GO:0016021|GO:0006996|GO:0007031|GO:0005777 cell|membrane|cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|intracellular membrane-bounded organelle|cytoplasm|integral component of membrane|organelle organization|peroxisome organization|peroxisome - - - - 11:87037844-87323758 112 181 261 526 688 846 0.915584955031535 1.34473963954345 1.92368400633803 3.85267240764801 4.61461210417211 6.48154307923144 1.39466953363767 4.98294253035052 -1.83707461855586 3.02647343353296e-10 7.36367871920887e-09 DOWN ENSG00000109920 FNBP4 formin binding protein 4 [Source:HGNC Symbol;Acc:HGNC:19752] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|nuclear lumen|nucleoplasm|nucleus - - - - 11:47716517-47767443 3280 3632 3219 1523 1696 1542 17.1991762049408 17.3085089249636 15.2184019928316 7.15535956638258 7.29671959058499 7.57786904529388 16.5753623742453 7.34331606742048 1.17453680900481 3.03354901151565e-10 7.37488372881011e-09 UP ENSG00000078177 N4BP2 NEDD4 binding protein 2 [Source:HGNC Symbol;Acc:HGNC:29851] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0016788|GO:0001882|GO:0016772|GO:0046483|GO:0005737|GO:0006139|GO:0000166|GO:0005829|GO:0035639|GO:0001883|GO:0032549|GO:0004518|GO:0016301|GO:0006796|GO:0017076|GO:0016773|GO:0051731|GO:0005524|GO:0030554|GO:0016310|GO:0019205|GO:0004519|GO:0090305|GO:0051733|GO:0046404 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cytoplasm|nucleobase-containing compound metabolic process|nucleotide binding|cytosol|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|nuclease activity|kinase activity|phosphate-containing compound metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|polynucleotide 5'-hydroxyl-kinase activity|ATP binding|adenyl nucleotide binding|phosphorylation|nucleobase-containing compound kinase activity|endonuclease activity|nucleic acid phosphodiester bond hydrolysis|polydeoxyribonucleotide kinase activity|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity - - - - 4:40056826-40158252 180 227 271 616 749 585 0.781335154590684 0.895511045447143 1.06059267469379 2.39575716269988 2.66756162647119 2.37984945396065 0.912479624910539 2.48105608104391 -1.44309009595284 3.07125046336525e-10 7.4604647138573e-09 DOWN ENSG00000273058 RP11-385F5.5 - - - - - - - 1:236536162-236536704 57 54 42 6 13 8 7.42537521255553 6.39321236145442 4.93298606907593 0.700340912782704 1.38945346317308 0.976715432361228 6.25052454769529 1.02216993610567 2.61234220190625 3.09644615069302e-10 7.51555312055199e-09 UP ENSG00000066855 MTFR1 mitochondrial fission regulator 1 [Source:HGNC Symbol;Acc:HGNC:29510] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0015980|GO:0043231|GO:0005737|GO:0006091|GO:0006996|GO:0055114|GO:0007005|GO:0005739|GO:0045333|GO:0000266|GO:0009060 cell|membrane|cellular process|metabolic process|intracellular organelle|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|energy derivation by oxidation of organic compounds|intracellular membrane-bounded organelle|cytoplasm|generation of precursor metabolites and energy|organelle organization|oxidation-reduction process|mitochondrion organization|mitochondrion|cellular respiration|mitochondrial fission|aerobic respiration - - - - 8:65644734-65771261 183 249 315 662 723 793 1.27047516915583 1.571063759186 1.97169356819234 4.11784412847773 4.11832168835211 5.15960591412977 1.60441083217806 4.4652572436532 -1.47669967980924 3.14464793164216e-10 7.62634600741227e-09 DOWN ENSG00000261584 RP11-457M11.5 - - - - - - - 6:26686241-26687964 0 1 1 18 20 20 0 0.0373072660887119 0.0369748711251998 0.661711849600336 0.673283909249797 0.769057970449632 0.0247607124046372 0.701351243099922 -4.82401241118614 3.14825395470349e-10 7.628893958094e-09 DOWN ENSG00000268713 CTC-444N24.8 - - - - - - - 19:57261354-57262738 148 154 166 46 59 53 7.55886725124239 7.14819098929726 7.64396363757364 2.10497543934318 2.47240245036351 2.53687191734402 7.45034062603776 2.37141660235024 1.65155725360457 3.22033130749878e-10 7.79722391354976e-09 UP ENSG00000279641 CTD-2545G14.6 - - - - - - - 17:7242200-7243814 70 44 35 4 9 5 3.06597411097105 1.75148067583843 1.3821662202527 0.156980439893089 0.323428212299343 0.205262689559748 2.06654033568739 0.228557113917393 3.17659089405045 3.26578750719377e-10 7.90087684276845e-09 UP ENSG00000175455 CCDC14 coiled-coil domain containing 14 [Source:HGNC Symbol;Acc:HGNC:25766] GO:0032502|GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0048856|GO:0007275|GO:0048513|GO:0048857|GO:0007420|GO:0005737|GO:0060322|GO:0030901|GO:0005813|GO:0007417|GO:0005815|GO:0021762|GO:0007399|GO:0005856|GO:0015630 developmental process|cell|binding|intracellular organelle|intracellular|protein binding|anatomical structure development|multicellular organism development|animal organ development|neural nucleus development|brain development|cytoplasm|head development|midbrain development|centrosome|central nervous system development|microtubule organizing center|substantia nigra development|nervous system development|cytoskeleton|microtubule cytoskeleton - - - - 3:123897305-123961408 263 392 511 1024 1134 1131 0.645070096330705 0.873810099317301 1.13001907822118 2.25034025832834 2.28208317409942 2.59981370550461 0.882966424623062 2.37741237931079 -1.42896168623342 3.31069306992236e-10 8.00303084287143e-09 DOWN ENSG00000121988 ZRANB3 zinc finger, RAN-binding domain containing 3 [Source:HGNC Symbol;Acc:HGNC:25249] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006281|GO:0032182|GO:0006725|GO:0009314|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0016788|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0043169|GO:0009890|GO:0006139|GO:0031297|GO:0000166|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0034645|GO:0051053|GO:0046872|GO:0035639|GO:0043130|GO:0001883|GO:0016818|GO:0005657|GO:0032549|GO:0031981|GO:0004518|GO:0006259|GO:0005694|GO:0000228|GO:0017076|GO:0009059|GO:0005634|GO:0009416|GO:0006974|GO:0008156|GO:0006260|GO:0043596|GO:0045910|GO:0004536|GO:0009411|GO:0036310|GO:0005524|GO:0030554|GO:0000018|GO:0006275|GO:0006310|GO:0004519|GO:0046914|GO:0090305|GO:0031593|GO:0071103|GO:0016462|GO:0000733|GO:0004520|GO:0006261|GO:0032392|GO:0017111|GO:0048478|GO:0070530|GO:0008270|GO:0036292 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|regulation of metabolic process|DNA repair|ubiquitin-like protein binding|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|replication fork processing|nucleotide binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|ubiquitin binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|replication fork|ribonucleoside binding|nuclear lumen|nuclease activity|DNA metabolic process|chromosome|nuclear chromosome|purine nucleotide binding|macromolecule biosynthetic process|nucleus|response to light stimulus|cellular response to DNA damage stimulus|negative regulation of DNA replication|DNA replication|nuclear replication fork|negative regulation of DNA recombination|deoxyribonuclease activity|response to UV|annealing helicase activity|ATP binding|adenyl nucleotide binding|regulation of DNA recombination|regulation of DNA replication|DNA recombination|endonuclease activity|transition metal ion binding|nucleic acid phosphodiester bond hydrolysis|polyubiquitin binding|DNA conformation change|pyrophosphatase activity|DNA strand renaturation|endodeoxyribonuclease activity|DNA-dependent DNA replication|DNA geometric change|nucleoside-triphosphatase activity|replication fork protection|K63-linked polyubiquitin binding|zinc ion binding|DNA rewinding - - - - 2:135136916-135531236 35 49 69 180 249 180 0.150356740836215 0.191309864358817 0.267252852255716 0.692831820718935 0.877658489260774 0.724700292709079 0.202973152483583 0.765063534229596 -1.91429064757438 3.35955202865412e-10 8.11456846791587e-09 DOWN ENSG00000146648 EGFR epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0000003|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0004872|GO:0009892|GO:0030055|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0005057|GO:0044702|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0009986|GO:0044237|GO:0051641|GO:0038023|GO:0003006|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0030234|GO:0005905|GO:0005622|GO:0002682|GO:0005789|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0030119|GO:0060341|GO:0008284|GO:0051272|GO:1903409|GO:0051726|GO:0042127|GO:0007049|GO:0048565|GO:0001890|GO:0016337|GO:0006281|GO:0006935|GO:0045087|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0009314|GO:0016323|GO:0006810|GO:0022402|GO:0070849|GO:0035295|GO:1901360|GO:2001022|GO:0010941|GO:0098797|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0043168|GO:0005924|GO:0006952|GO:0030900|GO:0005912|GO:2001057|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:2000147|GO:0033554|GO:0007420|GO:0030117|GO:0098609|GO:0043231|GO:0048608|GO:0019899|GO:0010243|GO:0004888|GO:0048144|GO:0001942|GO:0005737|GO:0060322|GO:0021987|GO:0007423|GO:0032880|GO:0012506|GO:0043235|GO:0051222|GO:0005635|GO:0006928|GO:0009887|GO:0032403|GO:0072593|GO:0030666|GO:0009966|GO:0048729|GO:0046983|GO:0048568|GO:0050673|GO:0045184|GO:0045787|GO:0003682|GO:0060548|GO:0032388|GO:0010646|GO:0006139|GO:0001892|GO:0043085|GO:0050776|GO:1900182|GO:0008104|GO:0030132|GO:0030235|GO:0007154|GO:0061024|GO:0051270|GO:0061029|GO:0016477|GO:0007165|GO:0005783|GO:0009968|GO:0001503|GO:0051649|GO:0004702|GO:0008092|GO:0009725|GO:0008219|GO:0007611|GO:0090316|GO:0031965|GO:0021543|GO:0010008|GO:0050790|GO:0000166|GO:0030030|GO:0031983|GO:0048869|GO:0016021|GO:2000145|GO:0021537|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0004716|GO:0031323|GO:0048732|GO:0005794|GO:0005768|GO:0071774|GO:0000165|GO:0016192|GO:0050679|GO:1902533|GO:0032268|GO:0000902|GO:0042307|GO:0031175|GO:0022029|GO:0003677|GO:0010468|GO:0034645|GO:0090150|GO:0055123|GO:0007166|GO:0001654|GO:0002009|GO:0033993|GO:0035639|GO:1903047|GO:0043412|GO:0072594|GO:0061458|GO:0030163|GO:0007417|GO:0031410|GO:0051345|GO:0030131|GO:0005769|GO:0043069|GO:0022405|GO:0046982|GO:0051252|GO:0032386|GO:0001883|GO:0003779|GO:0044770|GO:0051223|GO:0015031|GO:1901652|GO:0022612|GO:0000904|GO:0009790|GO:0071417|GO:0010628|GO:0030334|GO:0043200|GO:0016023|GO:0051347|GO:0021885|GO:0036211|GO:2000377|GO:0030665|GO:0000278|GO:0070201|GO:0046907|GO:0032549|GO:0046209|GO:0045739|GO:0071364|GO:0045737|GO:1903428|GO:0019902|GO:0048145|GO:0007431|GO:0070435|GO:0072657|GO:1901184|GO:2001020|GO:0007346|GO:0043434|GO:0051205|GO:0044344|GO:0010564|GO:0051247|GO:0048146|GO:0048471|GO:0070848|GO:0031988|GO:0045428|GO:0006259|GO:1901185|GO:0050678|GO:0002764|GO:0016301|GO:0035272|GO:0043588|GO:0031901|GO:1904591|GO:0034613|GO:0051341|GO:0051015|GO:0006282|GO:0030118|GO:0032270|GO:0030669|GO:0012501|GO:0014070|GO:0060429|GO:0021795|GO:0051054|GO:0006796|GO:0035556|GO:0030659|GO:0097487|GO:0044267|GO:0051174|GO:0042176|GO:0030122|GO:0010467|GO:0017038|GO:0032990|GO:0007399|GO:0071310|GO:0050890|GO:0097485|GO:0000139|GO:0017076|GO:0097489|GO:0031328|GO:0006809|GO:0051246|GO:0005771|GO:0009059|GO:0030154|GO:0048858|GO:0045121|GO:0030120|GO:0030335|GO:1903827|GO:0048546|GO:1902531|GO:0016070|GO:0004709|GO:0042177|GO:0016773|GO:0032870|GO:0010557|GO:0005634|GO:0009416|GO:0043067|GO:0048545|GO:0097305|GO:0006974|GO:1903426|GO:0006606|GO:0005925|GO:0044389|GO:0042633|GO:2000379|GO:0048666|GO:0030182|GO:0031625|GO:0051896|GO:0007411|GO:0043491|GO:1904589|GO:0060571|GO:0045893|GO:0033365|GO:1904031|GO:0033157|GO:0009792|GO:0031401|GO:0006260|GO:0008543|GO:0009411|GO:0030139|GO:0051169|GO:1901653|GO:0043408|GO:0043010|GO:0031659|GO:0042058|GO:0032774|GO:0005524|GO:0044772|GO:0030125|GO:2001141|GO:0071363|GO:0030554|GO:0016310|GO:0051897|GO:0043627|GO:0006605|GO:0002768|GO:0038179|GO:0070371|GO:0008544|GO:0071383|GO:0071407|GO:0003690|GO:0061564|GO:0016482|GO:1901990|GO:0019903|GO:0006886|GO:0048017|GO:0007167|GO:0030135|GO:0042059|GO:0071375|GO:0043410|GO:0006275|GO:0032355|GO:0042981|GO:0045429|GO:0043066|GO:0004672|GO:0032868|GO:1901987|GO:0007435|GO:0030128|GO:0042306|GO:0006897|GO:0045740|GO:1900180|GO:0022008|GO:0035413|GO:0048667|GO:0007264|GO:0004714|GO:0006464|GO:0019932|GO:0048812|GO:0071396|GO:0035411|GO:0000079|GO:0060193|GO:0043549|GO:0071230|GO:0006351|GO:0006915|GO:0006355|GO:0098773|GO:0033674|GO:0046824|GO:0048011|GO:0030136|GO:1903533|GO:0070141|GO:0000186|GO:0045944|GO:2000045|GO:0006366|GO:0007265|GO:0006913|GO:0045859|GO:0048015|GO:0045860|GO:0043406|GO:0006357|GO:0007409|GO:0010517|GO:0006468|GO:0048699|GO:0035412|GO:1903506|GO:0043405|GO:0042325|GO:0004713|GO:0070374|GO:0001932|GO:1902806|GO:0032869|GO:0018193|GO:0038093|GO:0071392|GO:0006898|GO:0000082|GO:0050999|GO:0004674|GO:0005006|GO:0043009|GO:0001934|GO:0019722|GO:0071391|GO:0010518|GO:0070372|GO:0045334|GO:0042327|GO:0034504|GO:0046822|GO:0007169|GO:0043006|GO:0048010|GO:0032430|GO:0010863|GO:0051170|GO:0050730|GO:0046777|GO:0038095|GO:0071902|GO:0071900|GO:0001701|GO:0032429|GO:0032147|GO:0008286|GO:0038127|GO:0018108|GO:0007173|GO:0032431|GO:0007202 locomotion|developmental process|macromolecular complex|signal transducer activity|reproduction|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|receptor signaling protein activity|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|immune response|response to abiotic stimulus|cell surface|cellular metabolic process|cellular localization|signaling receptor activity|developmental process involved in reproduction|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|enzyme regulator activity|coated pit|intracellular|regulation of immune system process|endoplasmic reticulum membrane|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|AP-type membrane coat adaptor complex|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|reactive oxygen species biosynthetic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|digestive tract development|placenta development|single organismal cell-cell adhesion|DNA repair|chemotaxis|innate immune response|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|response to radiation|basolateral plasma membrane|transport|cell cycle process|response to epidermal growth factor|tube development|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|regulation of cell death|plasma membrane protein complex|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|anion binding|cell-substrate adherens junction|defense response|forebrain development|adherens junction|reactive nitrogen species metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell motility|cellular response to stress|brain development|membrane coat|cell-cell adhesion|intracellular membrane-bounded organelle|reproductive structure development|enzyme binding|response to organonitrogen compound|transmembrane signaling receptor activity|fibroblast proliferation|hair follicle development|cytoplasm|head development|cerebral cortex development|sensory organ development|regulation of protein localization|vesicle membrane|receptor complex|positive regulation of protein transport|nuclear envelope|movement of cell or subcellular component|organ morphogenesis|protein complex binding|reactive oxygen species metabolic process|endocytic vesicle membrane|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic organ development|epithelial cell proliferation|establishment of protein localization|positive regulation of cell cycle|chromatin binding|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|positive regulation of catalytic activity|regulation of immune response|positive regulation of protein localization to nucleus|protein localization|clathrin coat of coated pit|nitric-oxide synthase regulator activity|cell communication|membrane organization|regulation of cellular component movement|eyelid development in camera-type eye|cell migration|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|ossification|establishment of localization in cell|receptor signaling protein serine/threonine kinase activity|cytoskeletal protein binding|response to hormone|cell death|learning or memory|positive regulation of intracellular protein transport|nuclear membrane|pallium development|endosome membrane|regulation of catalytic activity|nucleotide binding|cell projection organization|vesicle lumen|cellular developmental process|integral component of membrane|regulation of cell motility|telencephalon development|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|receptor signaling protein tyrosine kinase activity|regulation of cellular metabolic process|gland development|Golgi apparatus|endosome|response to fibroblast growth factor|MAPK cascade|vesicle-mediated transport|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|positive regulation of protein import into nucleus|neuron projection development|telencephalon cell migration|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|digestive system development|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|response to lipid|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|establishment of protein localization to organelle|reproductive system development|protein catabolic process|central nervous system development|cytoplasmic vesicle|positive regulation of hydrolase activity|clathrin adaptor complex|early endosome|negative regulation of programmed cell death|hair cycle process|protein heterodimerization activity|regulation of RNA metabolic process|regulation of intracellular transport|purine nucleoside binding|actin binding|cell cycle phase transition|regulation of protein transport|protein transport|response to peptide|gland morphogenesis|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|positive regulation of gene expression|regulation of cell migration|response to amino acid|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|forebrain cell migration|protein modification process|regulation of reactive oxygen species metabolic process|clathrin-coated vesicle membrane|mitotic cell cycle|regulation of establishment of protein localization|intracellular transport|ribonucleoside binding|nitric oxide metabolic process|positive regulation of DNA repair|cellular response to epidermal growth factor stimulus|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of reactive oxygen species biosynthetic process|phosphatase binding|regulation of fibroblast proliferation|salivary gland development|Shc-EGFR complex|protein localization to membrane|regulation of ERBB signaling pathway|regulation of response to DNA damage stimulus|regulation of mitotic cell cycle|response to peptide hormone|protein insertion into membrane|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|response to growth factor|membrane-bounded vesicle|regulation of nitric oxide biosynthetic process|DNA metabolic process|negative regulation of ERBB signaling pathway|regulation of epithelial cell proliferation|immune response-regulating signaling pathway|kinase activity|exocrine system development|skin development|early endosome membrane|positive regulation of protein import|cellular protein localization|regulation of oxidoreductase activity|actin filament binding|regulation of DNA repair|clathrin coat|positive regulation of cellular protein metabolic process|clathrin-coated endocytic vesicle membrane|programmed cell death|response to organic cyclic compound|epithelium development|cerebral cortex cell migration|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic vesicle membrane|multivesicular body, internal vesicle|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|AP-2 adaptor complex|gene expression|protein import|cell part morphogenesis|nervous system development|cellular response to organic substance|cognition|neuron projection guidance|Golgi membrane|purine nucleotide binding|multivesicular body, internal vesicle lumen|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|multivesicular body|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|membrane raft|vesicle coat|positive regulation of cell migration|regulation of cellular protein localization|digestive tract morphogenesis|regulation of intracellular signal transduction|RNA metabolic process|MAP kinase kinase kinase activity|negative regulation of protein catabolic process|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|regulation of programmed cell death|response to steroid hormone|response to alcohol|cellular response to DNA damage stimulus|regulation of reactive oxygen species biosynthetic process|protein import into nucleus|focal adhesion|ubiquitin-like protein ligase binding|hair cycle|positive regulation of reactive oxygen species metabolic process|neuron development|neuron differentiation|ubiquitin protein ligase binding|regulation of protein kinase B signaling|axon guidance|protein kinase B signaling|regulation of protein import|morphogenesis of an epithelial fold|positive regulation of transcription, DNA-templated|protein localization to organelle|positive regulation of cyclin-dependent protein kinase activity|regulation of intracellular protein transport|embryo development ending in birth or egg hatching|positive regulation of protein modification process|DNA replication|fibroblast growth factor receptor signaling pathway|response to UV|endocytic vesicle|nuclear transport|cellular response to peptide|regulation of MAPK cascade|camera-type eye development|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|regulation of epidermal growth factor receptor signaling pathway|RNA biosynthetic process|ATP binding|mitotic cell cycle phase transition|clathrin vesicle coat|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|positive regulation of protein kinase B signaling|response to estrogen|protein targeting|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|ERK1 and ERK2 cascade|epidermis development|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|axon development|cytosolic transport|regulation of mitotic cell cycle phase transition|protein phosphatase binding|intracellular protein transport|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|coated vesicle|negative regulation of epidermal growth factor receptor signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of DNA replication|response to estradiol|regulation of apoptotic process|positive regulation of nitric oxide biosynthetic process|negative regulation of apoptotic process|protein kinase activity|response to insulin|regulation of cell cycle phase transition|salivary gland morphogenesis|clathrin coat of endocytic vesicle|regulation of protein import into nucleus|endocytosis|positive regulation of DNA replication|regulation of protein localization to nucleus|neurogenesis|positive regulation of catenin import into nucleus|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|second-messenger-mediated signaling|neuron projection morphogenesis|cellular response to lipid|catenin import into nucleus|regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of lipase activity|regulation of kinase activity|cellular response to amino acid stimulus|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|skin epidermis development|positive regulation of kinase activity|positive regulation of nucleocytoplasmic transport|neurotrophin TRK receptor signaling pathway|clathrin-coated vesicle|regulation of protein targeting|response to UV-A|activation of MAPKK activity|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|Ras protein signal transduction|nucleocytoplasmic transport|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of transcription from RNA polymerase II promoter|axonogenesis|regulation of phospholipase activity|protein phosphorylation|generation of neurons|regulation of catenin import into nucleus|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|protein tyrosine kinase activity|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|cellular response to estradiol stimulus|receptor-mediated endocytosis|G1/S transition of mitotic cell cycle|regulation of nitric-oxide synthase activity|protein serine/threonine kinase activity|epidermal growth factor-activated receptor activity|chordate embryonic development|positive regulation of protein phosphorylation|calcium-mediated signaling|cellular response to estrogen stimulus|positive regulation of phospholipase activity|regulation of ERK1 and ERK2 cascade|clathrin-coated endocytic vesicle|positive regulation of phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|transmembrane receptor protein tyrosine kinase signaling pathway|activation of phospholipase A2 activity by calcium-mediated signaling|vascular endothelial growth factor receptor signaling pathway|positive regulation of phospholipase A2 activity|positive regulation of phospholipase C activity|nuclear import|regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|Fc-epsilon receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|in utero embryonic development|regulation of phospholipase A2 activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|epidermal growth factor receptor signaling pathway|activation of phospholipase A2 activity|activation of phospholipase C activity K04361 epidermal growth factor receptor[2.7.10.1] hsa05200|hsa04151|hsa04060|hsa04144|hsa05206|hsa04010|hsa04014|hsa04810|hsa04015|hsa05205|hsa04510|hsa04020|hsa04921|hsa04072|hsa04068|hsa05160|hsa04066|hsa05231|hsa04915|hsa04912|hsa05215|hsa04540|hsa04012|hsa04520|hsa05218|hsa05120|hsa05230|hsa05212|hsa05214|hsa05223|hsa05213|hsa05219|hsa04320 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Gap junction - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|Melanoma - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Glioma - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Bladder cancer - Homo sapiens (human)|Dorso-ventral axis formation - Homo sapiens (human) 7:55019021-55256620 2658 2834 6347 12875 14919 13538 10.783353794533 10.4490971260235 23.2156907064365 46.7997822126139 49.6599792207655 51.473337158218 14.8160472089977 49.3110328638658 -1.7347498710604 3.37872298101372e-10 8.14111346853781e-09 DOWN ENSG00000149179 C11orf49 chromosome 11 open reading frame 49 [Source:HGNC Symbol;Acc:HGNC:28720] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|nuclear lumen|nucleoplasm|nucleus - - - - 11:46936689-47164385 206 218 370 708 805 930 1.10392246794023 1.06171453433615 1.78767261390912 3.3994018794356 3.53944924979726 4.67071970028955 1.31776987206183 3.86985694317414 -1.55418178713976 3.37728175662446e-10 8.14111346853781e-09 DOWN ENSG00000181274 FRAT2 frequently rearranged in advanced T-cell lymphomas 2 [Source:HGNC Symbol;Acc:HGNC:16048] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0051716|GO:0008283|GO:0050794|GO:0023051|GO:0005622|GO:0048856|GO:0007275|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0009967|GO:0030111|GO:0005829|GO:0007166|GO:0030177|GO:0016055|GO:0060828|GO:0090263|GO:0060070 developmental process|signaling|cell|cellular process|response to stimulus|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of signaling|intracellular|anatomical structure development|multicellular organism development|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|positive regulation of signal transduction|regulation of Wnt signaling pathway|cytosol|cell surface receptor signaling pathway|positive regulation of Wnt signaling pathway|Wnt signaling pathway|regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|canonical Wnt signaling pathway K03096 frequently rearranged in advanced T-cell lymphomas 2[-] hsa04310 Wnt signaling pathway - Homo sapiens (human) 10:97332497-97334709 1050 1094 801 369 461 401 33.5624431382359 31.7805829973491 23.0840117742746 10.5678866399781 12.0901860677581 12.0126064996538 29.4756793032865 11.55689306913 1.35077146341219 3.37362734797865e-10 8.14111346853781e-09 UP ENSG00000167447 SMG8 SMG8 nonsense mediated mRNA decay factor [Source:HGNC Symbol;Acc:HGNC:25551] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0005737|GO:0006139|GO:0050790|GO:0019538|GO:0031323|GO:0032268|GO:0005829|GO:0043412|GO:0044265|GO:0036211|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0019439|GO:0051246|GO:0016070|GO:0006401|GO:0016310|GO:0016071|GO:0006464|GO:0043549|GO:0045859|GO:0006468|GO:0006402|GO:0042325|GO:0001932|GO:0000956|GO:0000184 cell|cellular process|metabolic process|binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cytoplasm|nucleobase-containing compound metabolic process|regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|macromolecule modification|cellular macromolecule catabolic process|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|aromatic compound catabolic process|regulation of protein metabolic process|RNA metabolic process|RNA catabolic process|phosphorylation|mRNA metabolic process|cellular protein modification process|regulation of kinase activity|regulation of protein kinase activity|protein phosphorylation|mRNA catabolic process|regulation of phosphorylation|regulation of protein phosphorylation|nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay - - - - 17:59209400-59215247 1107 1162 731 394 267 368 7.8517663095692 7.49042080763163 4.67467373559144 2.50388272238407 1.5538150817101 2.44622345525595 6.67228695093076 2.16797375311671 1.6218340446085 3.39029892543435e-10 8.16241807418686e-09 UP ENSG00000276550 HERC2P2 hect domain and RLD 2 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:4870] - - - - - - 15:22495570-22590815 455 608 719 1475 1604 1677 4.16422072878319 5.05715364385949 5.93288281659291 12.0951719166237 12.0446625788381 14.3841580172096 5.05141906307853 12.8413308375571 -1.34603408978542 3.4056032028584e-10 8.19265737454751e-09 DOWN ENSG00000116977 LGALS8 lectin, galactoside-binding, soluble, 8 [Source:HGNC Symbol;Acc:HGNC:6569] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0006950|GO:0006914|GO:0051707|GO:0030246|GO:0043227|GO:0009607|GO:0009605|GO:0005615|GO:0005622|GO:0005515|GO:0006952|GO:0031982|GO:0098542|GO:0005737|GO:0070062|GO:0016236|GO:0005829|GO:0098792 cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|response to stress|autophagy|response to other organism|carbohydrate binding|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|extracellular space|intracellular|protein binding|defense response|vesicle|defense response to other organism|cytoplasm|extracellular exosome|macroautophagy|cytosol|xenophagy - - - - 1:236518000-236552981 823 998 906 2235 2416 2588 2.2002496645667 2.42483798798999 2.18381067482672 5.35361989377823 5.29952739703719 6.48433754726775 2.26963277579447 5.71249494602772 -1.3316620939347 3.41402067093974e-10 8.20629413125885e-09 DOWN ENSG00000183864 TOB2 transducer of ERBB2, 2 [Source:HGNC Symbol;Acc:HGNC:11980] GO:0032502|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0002683|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0044702|GO:0071704|GO:0019953|GO:0043227|GO:0032504|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0042127|GO:1903706|GO:0045595|GO:0007275|GO:0045596|GO:0048513|GO:0005102|GO:0043231|GO:0005737|GO:0045778|GO:0007276|GO:0030278|GO:0001503|GO:0008134|GO:0008285|GO:0048869|GO:0042809|GO:0010468|GO:0030097|GO:0051427|GO:0010467|GO:0030154|GO:0007292|GO:0005634|GO:0045638|GO:0045637|GO:0002521|GO:0002761|GO:0035257|GO:0002762|GO:0030099|GO:0002573|GO:0045670|GO:0045671|GO:0030316 developmental process|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|binding|negative regulation of immune system process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|single organism reproductive process|organic substance metabolic process|sexual reproduction|membrane-bounded organelle|multicellular organism reproduction|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|regulation of cell proliferation|regulation of hemopoiesis|regulation of cell differentiation|multicellular organism development|negative regulation of cell differentiation|animal organ development|receptor binding|intracellular membrane-bounded organelle|cytoplasm|positive regulation of ossification|gamete generation|regulation of ossification|ossification|transcription factor binding|negative regulation of cell proliferation|cellular developmental process|vitamin D receptor binding|regulation of gene expression|hemopoiesis|hormone receptor binding|gene expression|cell differentiation|female gamete generation|nucleus|negative regulation of myeloid cell differentiation|regulation of myeloid cell differentiation|leukocyte differentiation|regulation of myeloid leukocyte differentiation|nuclear hormone receptor binding|negative regulation of myeloid leukocyte differentiation|myeloid cell differentiation|myeloid leukocyte differentiation|regulation of osteoclast differentiation|negative regulation of osteoclast differentiation|osteoclast differentiation K14443 protein Tob/BTG[-] hsa03018 RNA degradation - Homo sapiens (human) 22:41433492-41447023 2274 2197 1940 947 1075 824 30.1340595038128 26.4592385987862 23.1783845921028 11.2438455779305 11.6880856776459 10.2334758928491 26.5905608982339 11.0551357161418 1.26619747334257 3.42754469644448e-10 8.23217372225691e-09 UP ENSG00000110047 EHD1 EH domain containing 1 [Source:HGNC Symbol;Acc:HGNC:3242] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0043209|GO:0043167|GO:0051641|GO:0009653|GO:0097006|GO:0016043|GO:0010884|GO:0043227|GO:0071944|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0005929|GO:0048646|GO:0031090|GO:0060341|GO:0006949|GO:0050817|GO:0010883|GO:0045595|GO:0048468|GO:0006810|GO:0051130|GO:0060143|GO:0007275|GO:0060627|GO:0043168|GO:0031095|GO:0060170|GO:0001882|GO:0031982|GO:0051128|GO:0022607|GO:0061061|GO:0045597|GO:0043231|GO:0043169|GO:2001137|GO:0019899|GO:0005737|GO:0009611|GO:0042592|GO:1990089|GO:0045184|GO:0032388|GO:0008104|GO:0070062|GO:0051649|GO:0019915|GO:0010008|GO:0000166|GO:0030030|GO:0031253|GO:0048869|GO:0034381|GO:0010876|GO:0010033|GO:0010886|GO:0050878|GO:0005768|GO:0006996|GO:0016192|GO:0000902|GO:0031175|GO:0051149|GO:0046872|GO:0035639|GO:1990090|GO:0031410|GO:1901741|GO:0005769|GO:0042692|GO:0048878|GO:0007596|GO:0032386|GO:0005811|GO:0020018|GO:0001883|GO:0015031|GO:0051147|GO:2001135|GO:0016023|GO:0044782|GO:0042060|GO:0046907|GO:0032549|GO:0034383|GO:0055037|GO:0031094|GO:0007599|GO:0030031|GO:0010878|GO:0048471|GO:0070848|GO:0031988|GO:0006461|GO:0031901|GO:0034613|GO:0070925|GO:0042384|GO:0032990|GO:0007399|GO:0071310|GO:0017076|GO:0051020|GO:0030154|GO:0048858|GO:0055038|GO:0048666|GO:0030182|GO:1901739|GO:0060271|GO:0007520|GO:0051153|GO:0032561|GO:0033365|GO:0030139|GO:0051259|GO:0032456|GO:0005524|GO:0071363|GO:0030554|GO:0005509|GO:0006886|GO:0016197|GO:0031267|GO:0051146|GO:0005525|GO:0055088|GO:0006897|GO:0022008|GO:0019001|GO:0051155|GO:0010831|GO:0017016|GO:0048699|GO:0061512|GO:0014902|GO:0010830|GO:0051260|GO:0055092|GO:0017137|GO:0042632 developmental process|cell|membrane|cellular process|extracellular region|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|myelin sheath|ion binding|cellular localization|anatomical structure morphogenesis|regulation of plasma lipoprotein particle levels|cellular component organization|positive regulation of lipid storage|membrane-bounded organelle|cell periphery|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of cellular localization|syncytium formation|coagulation|regulation of lipid storage|regulation of cell differentiation|cell development|transport|positive regulation of cellular component organization|positive regulation of syncytium formation by plasma membrane fusion|multicellular organism development|regulation of vesicle-mediated transport|anion binding|platelet dense tubular network membrane|ciliary membrane|nucleoside binding|vesicle|regulation of cellular component organization|cellular component assembly|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|positive regulation of endocytic recycling|enzyme binding|cytoplasm|response to wounding|homeostatic process|response to nerve growth factor|establishment of protein localization|positive regulation of intracellular transport|protein localization|extracellular exosome|establishment of localization in cell|lipid storage|endosome membrane|nucleotide binding|cell projection organization|cell projection membrane|cellular developmental process|plasma lipoprotein particle clearance|lipid localization|response to organic substance|positive regulation of cholesterol storage|regulation of body fluid levels|endosome|organelle organization|vesicle-mediated transport|cell morphogenesis|neuron projection development|positive regulation of muscle cell differentiation|metal ion binding|purine ribonucleoside triphosphate binding|cellular response to nerve growth factor stimulus|cytoplasmic vesicle|positive regulation of myoblast fusion|early endosome|muscle cell differentiation|chemical homeostasis|blood coagulation|regulation of intracellular transport|lipid particle|ciliary pocket membrane|purine nucleoside binding|protein transport|regulation of muscle cell differentiation|regulation of endocytic recycling|cytoplasmic, membrane-bounded vesicle|cilium organization|wound healing|intracellular transport|ribonucleoside binding|low-density lipoprotein particle clearance|recycling endosome|platelet dense tubular network|hemostasis|cell projection assembly|cholesterol storage|perinuclear region of cytoplasm|response to growth factor|membrane-bounded vesicle|protein complex assembly|early endosome membrane|cellular protein localization|organelle assembly|cilium assembly|cell part morphogenesis|nervous system development|cellular response to organic substance|purine nucleotide binding|GTPase binding|cell differentiation|cell projection morphogenesis|recycling endosome membrane|neuron development|neuron differentiation|regulation of myoblast fusion|cilium morphogenesis|myoblast fusion|regulation of striated muscle cell differentiation|guanyl ribonucleotide binding|protein localization to organelle|endocytic vesicle|protein oligomerization|endocytic recycling|ATP binding|cellular response to growth factor stimulus|adenyl nucleotide binding|calcium ion binding|intracellular protein transport|endosomal transport|small GTPase binding|striated muscle cell differentiation|GTP binding|lipid homeostasis|endocytosis|neurogenesis|guanyl nucleotide binding|positive regulation of striated muscle cell differentiation|positive regulation of myotube differentiation|Ras GTPase binding|generation of neurons|protein localization to cilium|myotube differentiation|regulation of myotube differentiation|protein homooligomerization|sterol homeostasis|Rab GTPase binding|cholesterol homeostasis K12483 EH domain-containing protein 1[-] hsa04144 Endocytosis - Homo sapiens (human) 11:64851642-64888296 2992 3253 2602 1253 1520 1100 13.5739285032257 13.412446606281 10.6430318530308 5.0932239232019 5.65790382533764 4.67698095773744 12.5431356541792 5.14270290209233 1.28629933645962 3.48221268295598e-10 8.35675059782699e-09 UP ENSG00000143079 CTTNBP2NL CTTNBP2 N-terminal like [Source:HGNC Symbol;Acc:HGNC:25330] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0051051|GO:0044237|GO:0005622|GO:0005515|GO:0006810|GO:0019899|GO:0005737|GO:0044092|GO:0055085|GO:0032410|GO:0019538|GO:0034763|GO:0043412|GO:0036211|GO:0019902|GO:0006796|GO:0044267|GO:0005856|GO:0015629|GO:0016311|GO:0019903|GO:0006464|GO:0006470|GO:0051721 cell|cellular process|metabolic process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|negative regulation of transport|cellular metabolic process|intracellular|protein binding|transport|enzyme binding|cytoplasm|negative regulation of molecular function|transmembrane transport|negative regulation of transporter activity|protein metabolic process|negative regulation of transmembrane transport|macromolecule modification|protein modification process|phosphatase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|cytoskeleton|actin cytoskeleton|dephosphorylation|protein phosphatase binding|cellular protein modification process|protein dephosphorylation|protein phosphatase 2A binding - - - - 1:112396181-112463456 99 133 214 418 614 883 0.829238710022307 1.01246200132316 1.61612426116377 3.13703951861318 4.21970628529604 6.93163373718968 1.15260832416975 4.7627931803663 -2.04690555838252 3.50041697364335e-10 8.39369062900792e-09 DOWN ENSG00000090863 GLG1 golgi glycoprotein 1 [Source:HGNC Symbol;Acc:HGNC:4316] GO:0040011|GO:0032502|GO:0031012|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0005578|GO:0006950|GO:0071704|GO:0050900|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0043227|GO:0071944|GO:0023057|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0050817|GO:0045595|GO:0009888|GO:0019838|GO:0007275|GO:0048513|GO:0005102|GO:0031982|GO:0090287|GO:0043231|GO:0005737|GO:0009611|GO:0071559|GO:0006928|GO:0009887|GO:0009966|GO:0010646|GO:0090288|GO:0007154|GO:0016477|GO:0007165|GO:0009968|GO:0070062|GO:0060348|GO:0048869|GO:0016021|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0050878|GO:0005794|GO:0032268|GO:0048705|GO:0010468|GO:0051216|GO:0090101|GO:0007166|GO:0010629|GO:0007596|GO:0051604|GO:0032269|GO:0071560|GO:0042060|GO:0032330|GO:0007599|GO:0070848|GO:0006508|GO:0044267|GO:0010467|GO:0071310|GO:0060349|GO:0000139|GO:0051246|GO:0030154|GO:0001501|GO:0061448|GO:0061035|GO:0017134|GO:0016485|GO:0002062|GO:0030162|GO:0071363|GO:0007179|GO:0030512|GO:0007167|GO:0045861|GO:0017015|GO:0010955|GO:0070613|GO:0007178 locomotion|developmental process|extracellular matrix|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|response to stress|organic substance metabolic process|leukocyte migration|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|negative regulation of signaling|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|coagulation|regulation of cell differentiation|tissue development|growth factor binding|multicellular organism development|animal organ development|receptor binding|vesicle|regulation of cellular response to growth factor stimulus|intracellular membrane-bounded organelle|cytoplasm|response to wounding|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|regulation of signal transduction|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|cell communication|cell migration|signal transduction|negative regulation of signal transduction|extracellular exosome|bone development|cellular developmental process|integral component of membrane|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|Golgi apparatus|regulation of cellular protein metabolic process|skeletal system morphogenesis|regulation of gene expression|cartilage development|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|negative regulation of gene expression|blood coagulation|protein maturation|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|wound healing|regulation of chondrocyte differentiation|hemostasis|response to growth factor|proteolysis|cellular protein metabolic process|gene expression|cellular response to organic substance|bone morphogenesis|Golgi membrane|regulation of protein metabolic process|cell differentiation|skeletal system development|connective tissue development|regulation of cartilage development|fibroblast growth factor binding|protein processing|chondrocyte differentiation|regulation of proteolysis|cellular response to growth factor stimulus|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|negative regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway|negative regulation of protein processing|regulation of protein processing|transmembrane receptor protein serine/threonine kinase signaling pathway K06816 golgi apparatus protein 1[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 16:74447427-74607144 713 838 1458 2710 3095 3217 2.5345687042428 2.70731292987467 4.67289797831417 8.63140559452425 9.02699409488386 10.7175254658662 3.30492653747721 9.45864171842477 -1.51701482068969 3.52933486301158e-10 8.45624101126386e-09 DOWN ENSG00000214595 EML6 echinoderm microtubule associated protein like 6 [Source:HGNC Symbol;Acc:HGNC:35412] GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0005874|GO:0005737|GO:0005856|GO:0015630 cell|binding|intracellular organelle|intracellular|protein binding|microtubule|cytoplasm|cytoskeleton|microtubule cytoskeleton - - - - 2:54723499-54972025 20 32 52 130 171 211 0.0790709546116811 0.114978407474303 0.185356134332404 0.460499349767512 0.554689857875207 0.781805007459119 0.126468498806129 0.598998071700613 -2.24377328029385 3.53227277355707e-10 8.4564932944485e-09 DOWN ENSG00000150556 LYPD6B LY6/PLAUR domain containing 6B [Source:HGNC Symbol;Acc:HGNC:27018] GO:0005623|GO:0016020|GO:0071944|GO:0031224|GO:0005886|GO:0031225 cell|membrane|cell periphery|intrinsic component of membrane|plasma membrane|anchored component of membrane - - - - 2:149038107-149215262 20 21 25 94 90 119 0.237411901310992 0.226558779714437 0.267564679600767 0.999766368586395 0.876560454771492 1.32387832429167 0.243845120208732 1.06673504921652 -2.12916488386195 3.56120692328291e-10 8.5189320102314e-09 DOWN ENSG00000233927 RPS28 ribosomal protein S28 [Source:HGNC Symbol;Acc:HGNC:10418] GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016032|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0071166|GO:0034641|GO:0031982|GO:0046483|GO:0006413|GO:0005737|GO:0030529|GO:0045184|GO:0006139|GO:0008104|GO:0061024|GO:0070062|GO:0051649|GO:0006403|GO:0044249|GO:0022613|GO:0019538|GO:0005829|GO:0034645|GO:0090150|GO:0006518|GO:0051029|GO:0003723|GO:0072594|GO:0045047|GO:0005840|GO:0015031|GO:0044265|GO:0042254|GO:0046907|GO:0019083|GO:0072657|GO:0034613|GO:0050658|GO:0043603|GO:0044267|GO:0042274|GO:0010467|GO:0019058|GO:0019439|GO:0009059|GO:0015935|GO:0016070|GO:0006401|GO:0006364|GO:0043241|GO:0043043|GO:0006614|GO:0033365|GO:0022627|GO:0051169|GO:0006396|GO:0032774|GO:0034660|GO:0022626|GO:0006605|GO:0006407|GO:0006412|GO:0006886|GO:0016071|GO:0044822|GO:0006612|GO:0006405|GO:0072599|GO:0006414|GO:0070972|GO:0006613|GO:0006913|GO:0043624|GO:0006402|GO:0016072|GO:0006415|GO:0051168|GO:0000956|GO:0000184 macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|viral process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|ribonucleoprotein complex localization|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|membrane organization|extracellular exosome|establishment of localization in cell|RNA localization|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|cytosol|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|peptide metabolic process|rRNA transport|RNA binding|establishment of protein localization to organelle|protein targeting to ER|ribosome|protein transport|cellular macromolecule catabolic process|ribosome biogenesis|intracellular transport|viral transcription|protein localization to membrane|cellular protein localization|RNA transport|cellular amide metabolic process|cellular protein metabolic process|ribosomal small subunit biogenesis|gene expression|viral life cycle|aromatic compound catabolic process|macromolecule biosynthetic process|small ribosomal subunit|RNA metabolic process|RNA catabolic process|rRNA processing|protein complex disassembly|peptide biosynthetic process|SRP-dependent cotranslational protein targeting to membrane|protein localization to organelle|cytosolic small ribosomal subunit|nuclear transport|RNA processing|RNA biosynthetic process|ncRNA metabolic process|cytosolic ribosome|protein targeting|rRNA export from nucleus|translation|intracellular protein transport|mRNA metabolic process|poly(A) RNA binding|protein targeting to membrane|RNA export from nucleus|establishment of protein localization to endoplasmic reticulum|translational elongation|protein localization to endoplasmic reticulum|cotranslational protein targeting to membrane|nucleocytoplasmic transport|cellular protein complex disassembly|mRNA catabolic process|rRNA metabolic process|translational termination|nuclear export|nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay K02979 small subunit ribosomal protein S28e[-] hsa03010 Ribosome - Homo sapiens (human) 19:8321158-8323340 168 156 150 51 52 51 3.00398601185109 2.53509077965997 2.41821051721235 0.817069591918732 0.762894126569716 0.854650180678977 2.6524291029078 0.811537966389142 1.70858369425106 3.58876277653034e-10 8.57797629547933e-09 UP ENSG00000066777 ARFGEF1 ADP ribosylation factor guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:15772] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0005085|GO:0048856|GO:0031090|GO:0019222|GO:0006486|GO:0044262|GO:0048468|GO:0006810|GO:0007275|GO:0032535|GO:0032940|GO:0031325|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0032970|GO:0030529|GO:0009611|GO:0051018|GO:0005975|GO:0009966|GO:0045184|GO:0010646|GO:0005086|GO:0043085|GO:0008104|GO:0007163|GO:0007154|GO:0044092|GO:0007165|GO:0008092|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0030029|GO:0009967|GO:0044249|GO:0032878|GO:0019538|GO:0043254|GO:0031323|GO:0010256|GO:0005794|GO:0006996|GO:0016192|GO:1902533|GO:0005730|GO:0032268|GO:0006109|GO:0005829|GO:0031175|GO:0031333|GO:0034645|GO:2000114|GO:0005802|GO:0032956|GO:0043412|GO:0007010|GO:0007030|GO:0051345|GO:1903020|GO:0017022|GO:0030532|GO:0060050|GO:0015031|GO:0034237|GO:0006887|GO:0033578|GO:0009100|GO:0036211|GO:0042060|GO:0031981|GO:0030010|GO:0051247|GO:0048471|GO:0051346|GO:0005654|GO:0070085|GO:0016363|GO:0006461|GO:0030036|GO:0032270|GO:0035556|GO:1901137|GO:0033043|GO:0044267|GO:0007399|GO:0046903|GO:0000139|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0034399|GO:0030832|GO:1902531|GO:0010557|GO:0005634|GO:0060049|GO:0090303|GO:0048666|GO:0030182|GO:0051896|GO:0043491|GO:0009101|GO:0043413|GO:0010560|GO:0031401|GO:0034622|GO:0043623|GO:0090284|GO:0043087|GO:0051897|GO:0008064|GO:0043547|GO:0051494|GO:0051493|GO:0032272|GO:0010559|GO:0051056|GO:0022008|GO:0007264|GO:0006464|GO:0007015|GO:0034260|GO:0030833|GO:0061041|GO:0051258|GO:0007265|GO:0046578|GO:0048699|GO:0030837|GO:0008154|GO:0032012|GO:0030041 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|anatomical structure development|organelle membrane|regulation of metabolic process|protein glycosylation|cellular carbohydrate metabolic process|cell development|transport|multicellular organism development|regulation of cellular component size|secretion by cell|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|regulation of actin filament-based process|intracellular ribonucleoprotein complex|response to wounding|protein kinase A binding|carbohydrate metabolic process|regulation of signal transduction|establishment of protein localization|regulation of cell communication|ARF guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|protein localization|establishment or maintenance of cell polarity|cell communication|negative regulation of molecular function|signal transduction|cytoskeletal protein binding|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|positive regulation of signal transduction|cellular biosynthetic process|regulation of establishment or maintenance of cell polarity|protein metabolic process|regulation of protein complex assembly|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|vesicle-mediated transport|positive regulation of intracellular signal transduction|nucleolus|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|cytosol|neuron projection development|negative regulation of protein complex assembly|cellular macromolecule biosynthetic process|regulation of establishment of cell polarity|trans-Golgi network|regulation of actin cytoskeleton organization|macromolecule modification|cytoskeleton organization|Golgi organization|positive regulation of hydrolase activity|positive regulation of glycoprotein metabolic process|myosin binding|small nuclear ribonucleoprotein complex|positive regulation of protein glycosylation|protein transport|protein kinase A regulatory subunit binding|exocytosis|protein glycosylation in Golgi|glycoprotein metabolic process|protein modification process|wound healing|nuclear lumen|establishment of cell polarity|positive regulation of protein metabolic process|perinuclear region of cytoplasm|negative regulation of hydrolase activity|nucleoplasm|glycosylation|nuclear matrix|protein complex assembly|actin cytoskeleton organization|positive regulation of cellular protein metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|nervous system development|secretion|Golgi membrane|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|nuclear periphery|regulation of actin filament length|regulation of intracellular signal transduction|positive regulation of macromolecule biosynthetic process|nucleus|regulation of protein glycosylation|positive regulation of wound healing|neuron development|neuron differentiation|regulation of protein kinase B signaling|protein kinase B signaling|glycoprotein biosynthetic process|macromolecule glycosylation|positive regulation of glycoprotein biosynthetic process|positive regulation of protein modification process|cellular macromolecular complex assembly|cellular protein complex assembly|positive regulation of protein glycosylation in Golgi|regulation of GTPase activity|positive regulation of protein kinase B signaling|regulation of actin polymerization or depolymerization|positive regulation of GTPase activity|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|regulation of glycoprotein biosynthetic process|regulation of small GTPase mediated signal transduction|neurogenesis|small GTPase mediated signal transduction|cellular protein modification process|actin filament organization|negative regulation of GTPase activity|regulation of actin filament polymerization|regulation of wound healing|protein polymerization|Ras protein signal transduction|regulation of Ras protein signal transduction|generation of neurons|negative regulation of actin filament polymerization|actin polymerization or depolymerization|regulation of ARF protein signal transduction|actin filament polymerization K18442 brefeldin A-inhibited guanine nucleotide-exchange protein[-] hsa04144 Endocytosis - Homo sapiens (human) 8:67173511-67343677 490 578 884 1741 1869 1813 2.31351195483743 2.48018431791603 3.76307098526982 7.36499222220629 7.24024339526862 8.02236997426171 2.85225575267443 7.54253519724554 -1.40294617428117 3.61739841870942e-10 8.63950499137208e-09 DOWN ENSG00000171100 MTM1 myotubularin 1 [Source:HGNC Symbol;Acc:HGNC:7448] GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0006914|GO:0023051|GO:0009653|GO:0016043|GO:0045927|GO:0043227|GO:0008289|GO:0071944|GO:0040008|GO:0009605|GO:0023057|GO:0031252|GO:0016787|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0010507|GO:0030017|GO:0044255|GO:0010506|GO:0051640|GO:0009888|GO:1902115|GO:0045103|GO:0006810|GO:0009991|GO:0007275|GO:0048513|GO:0043168|GO:0016788|GO:0044281|GO:0005543|GO:0031982|GO:0019637|GO:0051128|GO:0033554|GO:0022607|GO:0061061|GO:0043231|GO:0005737|GO:0001726|GO:0032403|GO:0042592|GO:0009966|GO:0045184|GO:0019725|GO:0048639|GO:0031674|GO:0010646|GO:0008104|GO:0007154|GO:0006629|GO:0007165|GO:0009968|GO:0070062|GO:0048638|GO:1901863|GO:0051649|GO:0016236|GO:0048869|GO:0048630|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0005768|GO:0006996|GO:0032268|GO:0051646|GO:0005829|GO:0008654|GO:0046486|GO:0043412|GO:0007010|GO:0030163|GO:0007005|GO:0035091|GO:0015031|GO:2000785|GO:0044265|GO:0070584|GO:0045844|GO:0046716|GO:0036211|GO:0032269|GO:0060537|GO:0046907|GO:0016241|GO:0043292|GO:0005770|GO:0048633|GO:0006508|GO:0030175|GO:0019215|GO:0070925|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0042176|GO:0032990|GO:0008610|GO:1902532|GO:0016242|GO:0051246|GO:0007517|GO:0030258|GO:1902531|GO:0000045|GO:0042177|GO:0031667|GO:0045104|GO:0048311|GO:0042578|GO:0006644|GO:0007033|GO:0048631|GO:0016202|GO:0045109|GO:0051896|GO:0043491|GO:0060538|GO:0044257|GO:0032006|GO:0016311|GO:0030016|GO:0051898|GO:0046839|GO:0010498|GO:0048641|GO:0031929|GO:0046474|GO:0048643|GO:1903363|GO:0030162|GO:1902902|GO:0044088|GO:0051603|GO:0016197|GO:0045861|GO:0016791|GO:0014706|GO:0006464|GO:0007034|GO:0006650|GO:0032007|GO:0006470|GO:0008333|GO:0046488|GO:0007041|GO:0019941|GO:0007519|GO:0006661|GO:0004721|GO:1901799|GO:0046856|GO:0052866|GO:1903051|GO:0061136|GO:0043161|GO:0035335|GO:0006511|GO:0032434|GO:0032435|GO:0034593|GO:0004725|GO:0004438|GO:0052629 developmental process|growth|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|autophagy|regulation of signaling|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|membrane-bounded organelle|lipid binding|cell periphery|regulation of growth|response to external stimulus|negative regulation of signaling|cell leading edge|hydrolase activity|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|negative regulation of autophagy|sarcomere|cellular lipid metabolic process|regulation of autophagy|organelle localization|tissue development|regulation of organelle assembly|intermediate filament-based process|transport|response to extracellular stimulus|multicellular organism development|animal organ development|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|phospholipid binding|vesicle|organophosphate metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|muscle structure development|intracellular membrane-bounded organelle|cytoplasm|ruffle|protein complex binding|homeostatic process|regulation of signal transduction|establishment of protein localization|cellular homeostasis|positive regulation of developmental growth|I band|regulation of cell communication|protein localization|cell communication|lipid metabolic process|signal transduction|negative regulation of signal transduction|extracellular exosome|regulation of developmental growth|positive regulation of muscle tissue development|establishment of localization in cell|macroautophagy|cellular developmental process|skeletal muscle tissue growth|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endosome|organelle organization|regulation of cellular protein metabolic process|mitochondrion localization|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|macromolecule modification|cytoskeleton organization|protein catabolic process|mitochondrion organization|phosphatidylinositol binding|protein transport|regulation of autophagosome assembly|cellular macromolecule catabolic process|mitochondrion morphogenesis|positive regulation of striated muscle tissue development|muscle cell cellular homeostasis|protein modification process|negative regulation of cellular protein metabolic process|muscle tissue development|intracellular transport|regulation of macroautophagy|contractile fiber|late endosome|positive regulation of skeletal muscle tissue growth|proteolysis|filopodium|intermediate filament binding|organelle assembly|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|cell part morphogenesis|lipid biosynthetic process|negative regulation of intracellular signal transduction|negative regulation of macroautophagy|regulation of protein metabolic process|muscle organ development|lipid modification|regulation of intracellular signal transduction|autophagosome assembly|negative regulation of protein catabolic process|response to nutrient levels|intermediate filament cytoskeleton organization|mitochondrion distribution|phosphoric ester hydrolase activity|phospholipid metabolic process|vacuole organization|regulation of skeletal muscle tissue growth|regulation of striated muscle tissue development|intermediate filament organization|regulation of protein kinase B signaling|protein kinase B signaling|skeletal muscle organ development|cellular protein catabolic process|regulation of TOR signaling|dephosphorylation|myofibril|negative regulation of protein kinase B signaling|phospholipid dephosphorylation|proteasomal protein catabolic process|regulation of skeletal muscle tissue development|TOR signaling|glycerophospholipid biosynthetic process|positive regulation of skeletal muscle tissue development|negative regulation of cellular protein catabolic process|regulation of proteolysis|negative regulation of autophagosome assembly|regulation of vacuole organization|proteolysis involved in cellular protein catabolic process|endosomal transport|negative regulation of proteolysis|phosphatase activity|striated muscle tissue development|cellular protein modification process|vacuolar transport|glycerophospholipid metabolic process|negative regulation of TOR signaling|protein dephosphorylation|endosome to lysosome transport|phosphatidylinositol metabolic process|lysosomal transport|modification-dependent protein catabolic process|skeletal muscle tissue development|phosphatidylinositol biosynthetic process|phosphoprotein phosphatase activity|negative regulation of proteasomal protein catabolic process|phosphatidylinositol dephosphorylation|phosphatidylinositol phosphate phosphatase activity|negative regulation of proteolysis involved in cellular protein catabolic process|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|peptidyl-tyrosine dephosphorylation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|phosphatidylinositol bisphosphate phosphatase activity|protein tyrosine phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity K01108 myotubularin[3.1.3.95] hsa01100|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) X:150568619-150673322 70 74 155 357 386 423 0.842100032179974 0.809057883308017 1.68118442861437 3.84799779272134 3.80999280674101 4.76911498848552 1.11078078136745 4.14236852931596 -1.89888178875025 3.65960130878506e-10 8.73331234791919e-09 DOWN ENSG00000179562 GCC1 GRIP and coiled-coil domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19095] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0051649|GO:0005794|GO:0016192|GO:0072594|GO:0015031|GO:0046907|GO:0034613|GO:0000139|GO:0000042|GO:0072600|GO:0033365|GO:0006605|GO:0048193|GO:0006886|GO:0034067|GO:0006891|GO:0000301 cell|membrane|binding|intracellular organelle|cellular localization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|establishment of localization in cell|Golgi apparatus|vesicle-mediated transport|establishment of protein localization to organelle|protein transport|intracellular transport|cellular protein localization|Golgi membrane|protein targeting to Golgi|establishment of protein localization to Golgi|protein localization to organelle|protein targeting|Golgi vesicle transport|intracellular protein transport|protein localization to Golgi apparatus|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi - - - - 7:127580618-127593611 1393 1570 1299 630 668 639 17.639895868733 18.0685975586772 14.8309201973209 7.1479754135075 6.94047566735672 7.58358038894414 16.8464712082437 7.22401048993612 1.22157453216521 3.67609216431648e-10 8.76565938286775e-09 UP ENSG00000279520 RP11-20I23.2 - - - - - - - 16:2516658-2517999 103 90 91 29 24 24 5.42915157889712 4.31136899188991 4.32461688585438 1.36960705401802 1.03795547580859 1.1855957073893 4.6883791522138 1.1977194124053 1.96879927603653 3.73698381215423e-10 8.90374419218295e-09 UP ENSG00000156697 UTP14A UTP14A small subunit processome component [Source:HGNC Symbol;Acc:HGNC:10665] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0022613|GO:0005730|GO:0003723|GO:0030684|GO:0042254|GO:0031981|GO:0010467|GO:0016070|GO:0005634|GO:0006364|GO:0006396|GO:0034660|GO:0032040|GO:0044822|GO:0016072 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|preribosome|ribosome biogenesis|nuclear lumen|gene expression|RNA metabolic process|nucleus|rRNA processing|RNA processing|ncRNA metabolic process|small-subunit processome|poly(A) RNA binding|rRNA metabolic process K14567 U3 small nucleolar RNA-associated protein 14[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) X:129906121-129929761 5061 4910 2811 1536 1583 1001 70.0859880010398 61.7954344466408 35.0969978763071 19.0582849599224 17.9863728239445 12.9914549920993 55.6594734413292 16.6787042586554 1.73862004780909 3.90295169111744e-10 9.28436014236016e-09 UP ENSG00000158480 SPATA2 spermatogenesis associated 2 [Source:HGNC Symbol;Acc:HGNC:14681] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0043229|GO:0044702|GO:0019953|GO:0043227|GO:0032504|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0007275|GO:0043231|GO:0005737|GO:0007276|GO:0048869|GO:0005730|GO:0048232|GO:0031981|GO:0030154|GO:0005634|GO:0007283 developmental process|reproduction|cell|cellular process|reproductive process|binding|intracellular organelle|single organism reproductive process|sexual reproduction|membrane-bounded organelle|multicellular organism reproduction|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|multicellular organism development|intracellular membrane-bounded organelle|cytoplasm|gamete generation|cellular developmental process|nucleolus|male gamete generation|nuclear lumen|cell differentiation|nucleus|spermatogenesis - - - - 20:49903391-49915508 899 926 824 374 403 422 8.23522684571696 7.70915599255816 6.80546229969142 3.06962826423357 3.0289261333566 3.62290991801569 7.58328171265551 3.24048810520195 1.22661118044959 3.90265552375922e-10 9.28436014236016e-09 UP ENSG00000153207 AHCTF1 AT-hook containing transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:24618] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:1903561|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0007049|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0000776|GO:0031982|GO:0046483|GO:0022607|GO:0031080|GO:0043231|GO:0005737|GO:0005635|GO:0045184|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0006403|GO:0031965|GO:0051301|GO:0044249|GO:0031323|GO:0006996|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0015031|GO:0000278|GO:0031981|GO:0005654|GO:0016363|GO:0005694|GO:0006461|GO:0050658|GO:0035556|GO:0010467|GO:0006997|GO:0009059|GO:0034399|GO:0016070|GO:0000910|GO:0005634|GO:0000777|GO:0005643|GO:0006999|GO:0034622|GO:0051028|GO:0032774|GO:0000793|GO:2001141|GO:0043623|GO:0046931|GO:0007264|GO:0006351|GO:0006355|GO:0000775|GO:0000779|GO:1903506|GO:0051292 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|kinetochore|vesicle|heterocycle metabolic process|cellular component assembly|nuclear pore outer ring|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|extracellular exosome|RNA localization|nuclear membrane|cell division|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|protein transport|mitotic cell cycle|nuclear lumen|nucleoplasm|nuclear matrix|chromosome|protein complex assembly|RNA transport|intracellular signal transduction|gene expression|nucleus organization|macromolecule biosynthetic process|nuclear periphery|RNA metabolic process|cytokinesis|nucleus|condensed chromosome kinetochore|nuclear pore|nuclear pore organization|cellular macromolecular complex assembly|mRNA transport|RNA biosynthetic process|condensed chromosome|regulation of RNA biosynthetic process|cellular protein complex assembly|pore complex assembly|small GTPase mediated signal transduction|transcription, DNA-templated|regulation of transcription, DNA-templated|chromosome, centromeric region|condensed chromosome, centromeric region|regulation of nucleic acid-templated transcription|nuclear pore complex assembly - - - - 1:246839098-246931978 1461 1527 1175 4310 4867 3410 8.52131756151585 8.09423337714615 6.17886230373542 22.5232719090471 23.290879787515 18.6397435676476 7.59813774746581 21.4846317547366 -1.49958727749173 3.96113808584888e-10 9.41527200755832e-09 DOWN ENSG00000117360 PRPF3 pre-mRNA processing factor 3 [Source:HGNC Symbol;Acc:HGNC:17348] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0042802|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0030529|GO:0006139|GO:0022613|GO:0003723|GO:0030532|GO:0022618|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0097525|GO:0034622|GO:0006396|GO:0016604|GO:0016071|GO:0044822|GO:0000387|GO:0016607|GO:0015030|GO:0000244|GO:0006397|GO:0097526|GO:0008380|GO:0000375|GO:0046540|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|RNA binding|small nuclear ribonucleoprotein complex|ribonucleoprotein complex assembly|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|spliceosomal snRNP complex|cellular macromolecular complex assembly|RNA processing|nuclear body|mRNA metabolic process|poly(A) RNA binding|spliceosomal snRNP assembly|nuclear speck|Cajal body|spliceosomal tri-snRNP complex assembly|mRNA processing|spliceosomal tri-snRNP complex|RNA splicing|RNA splicing, via transesterification reactions|U4/U6 x U5 tri-snRNP complex|mRNA splicing, via spliceosome K12843 U4/U6 small nuclear ribonucleoprotein PRP3[-] hsa03040 Spliceosome - Homo sapiens (human) 1:150321476-150353195 2421 2538 1979 1040 1098 801 26.5468827068439 25.2924222715767 19.5649451027726 10.2176162724673 9.87845798939289 8.23152707159206 23.8014166937311 9.44253377781742 1.333801502729 3.99843946494759e-10 9.49637325270846e-09 UP ENSG00000091527 CDV3 CDV3 homolog (mouse) [Source:HGNC Symbol;Acc:HGNC:26928] GO:0005623|GO:0016020|GO:0008283|GO:0043229|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0043231|GO:0005737|GO:0005730|GO:0031981|GO:0005634 cell|membrane|cell proliferation|intracellular organelle|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|intracellular membrane-bounded organelle|cytoplasm|nucleolus|nuclear lumen|nucleus - - - - 3:133573730-133590261 4042 4791 3675 1528 2003 1939 30.3329492772344 32.6756694018008 24.8650788896197 10.273994563381 12.3329543821324 13.637195907409 29.291232522885 12.0813816176408 1.27768345092337 4.02466483222129e-10 9.55106072346061e-09 UP ENSG00000136937 NCBP1 nuclear cap binding protein subunit 1 [Source:HGNC Symbol;Acc:HGNC:7658] GO:0040007|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0016032|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0071166|GO:0034641|GO:0030307|GO:0048524|GO:0031325|GO:0046483|GO:0005845|GO:0051128|GO:0022607|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0034518|GO:0005846|GO:0016458|GO:0006139|GO:0051649|GO:0006403|GO:0044249|GO:0022613|GO:0019538|GO:0050792|GO:0001558|GO:0031323|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0031047|GO:0010629|GO:0051252|GO:0006446|GO:0044265|GO:0010628|GO:0046907|GO:0019083|GO:0022618|GO:0031981|GO:0005654|GO:0005739|GO:0050658|GO:0043603|GO:0044267|GO:1903902|GO:0010467|GO:0019058|GO:0031328|GO:0019439|GO:0051246|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0006401|GO:0043043|GO:0090501|GO:0000339|GO:0034622|GO:0051028|GO:0051169|GO:0006396|GO:0050684|GO:0046782|GO:0032774|GO:0034660|GO:2001141|GO:0010608|GO:0006412|GO:0016071|GO:0006417|GO:0044822|GO:0090305|GO:0000387|GO:0006406|GO:0050434|GO:0006405|GO:0006351|GO:0031442|GO:0006366|GO:0006913|GO:0006402|GO:0008334|GO:0006354|GO:0031440|GO:0006397|GO:0006379|GO:0008380|GO:0006353|GO:0031123|GO:0006368|GO:0000375|GO:0051168|GO:0000956|GO:0006370|GO:0031124|GO:0006369|GO:0009452|GO:0000398|GO:0000184|GO:0045292|GO:0098789 growth|macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|ribonucleoprotein complex localization|cellular nitrogen compound metabolic process|positive regulation of cell growth|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|mRNA cap binding complex|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|RNA cap binding complex|nuclear cap binding complex|gene silencing|nucleobase-containing compound metabolic process|establishment of localization in cell|RNA localization|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|regulation of viral process|regulation of cell growth|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|gene silencing by RNA|negative regulation of gene expression|regulation of RNA metabolic process|regulation of translational initiation|cellular macromolecule catabolic process|positive regulation of gene expression|intracellular transport|viral transcription|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|mitochondrion|RNA transport|cellular amide metabolic process|cellular protein metabolic process|positive regulation of viral life cycle|gene expression|viral life cycle|positive regulation of cellular biosynthetic process|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|RNA catabolic process|peptide biosynthetic process|RNA phosphodiester bond hydrolysis|RNA cap binding|cellular macromolecular complex assembly|mRNA transport|nuclear transport|RNA processing|regulation of mRNA processing|regulation of viral transcription|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|translation|mRNA metabolic process|regulation of translation|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|spliceosomal snRNP assembly|mRNA export from nucleus|positive regulation of viral transcription|RNA export from nucleus|transcription, DNA-templated|positive regulation of mRNA 3'-end processing|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|mRNA catabolic process|histone mRNA metabolic process|DNA-templated transcription, elongation|regulation of mRNA 3'-end processing|mRNA processing|mRNA cleavage|RNA splicing|DNA-templated transcription, termination|RNA 3'-end processing|transcription elongation from RNA polymerase II promoter|RNA splicing, via transesterification reactions|nuclear export|nuclear-transcribed mRNA catabolic process|7-methylguanosine mRNA capping|mRNA 3'-end processing|termination of RNA polymerase II transcription|7-methylguanosine RNA capping|mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA cis splicing, via spliceosome|pre-mRNA cleavage required for polyadenylation K12882 nuclear cap-binding protein subunit 1[-] hsa03013|hsa03040|hsa03015 RNA transport - Homo sapiens (human)|Spliceosome - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human) 9:97633626-97673748 573 697 730 1987 2207 1431 6.40420603671072 7.07983567289766 7.35610309483861 19.8978496237446 20.2386177523276 14.9892272027702 6.94671493481566 18.3752315262808 -1.40335962662437 4.06685586974962e-10 9.6435198677923e-09 DOWN ENSG00000078114 NEBL nebulette [Source:HGNC Symbol;Acc:HGNC:16932] GO:0032502|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0044877|GO:0043229|GO:0043167|GO:0009653|GO:0016043|GO:0043227|GO:0008307|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0030017|GO:0007507|GO:0030018|GO:0009888|GO:0048468|GO:0007275|GO:0048513|GO:0031982|GO:0022607|GO:0061061|GO:0043169|GO:0005737|GO:0032403|GO:0031674|GO:0070062|GO:0008092|GO:0048869|GO:0030029|GO:0006996|GO:0046872|GO:0031005|GO:0007010|GO:0072358|GO:0042692|GO:0005523|GO:0035051|GO:0048738|GO:0003779|GO:0055006|GO:0032432|GO:0060537|GO:0043292|GO:0055001|GO:0030036|GO:0042641|GO:0051015|GO:0070925|GO:0030154|GO:0030239|GO:0072359|GO:0005856|GO:0055002|GO:0015629|GO:0055003|GO:0030016|GO:0055013|GO:0001725|GO:0051146|GO:0046914|GO:0031032|GO:0014706|GO:0055007|GO:0007015|GO:0071691|GO:0008270 developmental process|structural molecule activity|cell|cellular process|extracellular region|binding|extracellular vesicle|macromolecular complex binding|intracellular organelle|ion binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|structural constituent of muscle|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|sarcomere|heart development|Z disc|tissue development|cell development|multicellular organism development|animal organ development|vesicle|cellular component assembly|muscle structure development|cation binding|cytoplasm|protein complex binding|I band|extracellular exosome|cytoskeletal protein binding|cellular developmental process|actin filament-based process|organelle organization|metal ion binding|filamin binding|cytoskeleton organization|cardiovascular system development|muscle cell differentiation|tropomyosin binding|cardiocyte differentiation|cardiac muscle tissue development|actin binding|cardiac cell development|actin filament bundle|muscle tissue development|contractile fiber|muscle cell development|actin cytoskeleton organization|actomyosin|actin filament binding|organelle assembly|cell differentiation|myofibril assembly|circulatory system development|cytoskeleton|striated muscle cell development|actin cytoskeleton|cardiac myofibril assembly|myofibril|cardiac muscle cell development|stress fiber|striated muscle cell differentiation|transition metal ion binding|actomyosin structure organization|striated muscle tissue development|cardiac muscle cell differentiation|actin filament organization|cardiac muscle thin filament assembly|zinc ion binding - - - - 10:20779973-21174187 31 45 96 215 326 474 0.128341322885196 0.169317512478988 0.358337790880078 0.797518578010015 1.10736375291463 1.83913099889154 0.218665542081421 1.24800444327206 -2.51282527108849 4.09181165259338e-10 9.69499564099386e-09 DOWN ENSG00000058729 RIOK2 RIO kinase 2 [Source:HGNC Symbol;Acc:HGNC:18999] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0043167|GO:0044237|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043169|GO:0000166|GO:0019538|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|ion binding|cellular metabolic process|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|nucleotide binding|protein metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity K07179 RIO kinase 2[2.7.11.1] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 5:97160867-97183260 1001 1035 841 434 461 351 9.51970643023443 8.94561023471505 7.21107466899495 3.69808985969315 3.59714732024049 3.12841998041752 8.55879711131481 3.47455238678372 1.30058091560058 4.11191014900299e-10 9.73489021319075e-09 UP ENSG00000162772 ATF3 activating transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:785] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0000989|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042802|GO:0008284|GO:0042127|GO:0003712|GO:0006725|GO:0009888|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0003676|GO:0048513|GO:0046685|GO:0034641|GO:0044281|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0061061|GO:0043231|GO:0000981|GO:0031668|GO:0005975|GO:0009966|GO:0046983|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:1990622|GO:0009968|GO:0008219|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0042594|GO:0000165|GO:0000982|GO:0005730|GO:2001235|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0007166|GO:0030968|GO:0043412|GO:0010629|GO:0043620|GO:0006984|GO:0046982|GO:0051252|GO:0010628|GO:0036211|GO:0032269|GO:0060537|GO:0006986|GO:0031981|GO:0005996|GO:0005654|GO:0009267|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0071243|GO:0001227|GO:1902532|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0001228|GO:0043068|GO:0007517|GO:0031669|GO:0035967|GO:1902531|GO:0016070|GO:0031667|GO:0034976|GO:0010557|GO:0005634|GO:0016051|GO:0042803|GO:0043067|GO:0097190|GO:0034620|GO:0019318|GO:0060538|GO:0000975|GO:0045893|GO:0061394|GO:0043065|GO:0001078|GO:0043408|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:2001236|GO:0016310|GO:1902679|GO:2001238|GO:0070371|GO:0036499|GO:0003690|GO:0035914|GO:0042981|GO:0034198|GO:0043409|GO:1990440|GO:0014706|GO:0006464|GO:0097191|GO:0006351|GO:0006915|GO:0006355|GO:0043618|GO:0045944|GO:0006366|GO:0019319|GO:1903507|GO:0006357|GO:1902043|GO:0006468|GO:0007519|GO:1903506|GO:0006006|GO:0044212|GO:0036003|GO:0042325|GO:0001932|GO:0042326|GO:0001933|GO:0000122|GO:0070372|GO:0070373|GO:0008625|GO:1902041|GO:0000976|GO:0001012|GO:0006094|GO:0001159|GO:1903984|GO:0036462|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|identical protein binding|positive regulation of cell proliferation|regulation of cell proliferation|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|nucleic acid binding|animal organ development|response to arsenic-containing substance|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|muscle structure development|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cellular response to extracellular stimulus|carbohydrate metabolic process|regulation of signal transduction|protein dimerization activity|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|CHOP-ATF3 complex|negative regulation of signal transduction|cell death|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to starvation|MAPK cascade|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nucleolus|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|cell surface receptor signaling pathway|endoplasmic reticulum unfolded protein response|macromolecule modification|negative regulation of gene expression|regulation of DNA-templated transcription in response to stress|ER-nucleus signaling pathway|protein heterodimerization activity|regulation of RNA metabolic process|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|muscle tissue development|response to unfolded protein|nuclear lumen|monosaccharide metabolic process|nucleoplasm|cellular response to starvation|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|cellular response to arsenic-containing substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of programmed cell death|muscle organ development|cellular response to nutrient levels|cellular response to topologically incorrect protein|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|nucleus|carbohydrate biosynthetic process|protein homodimerization activity|regulation of programmed cell death|apoptotic signaling pathway|cellular response to unfolded protein|hexose metabolic process|skeletal muscle organ development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance|positive regulation of apoptotic process|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of extrinsic apoptotic signaling pathway|phosphorylation|negative regulation of RNA biosynthetic process|positive regulation of extrinsic apoptotic signaling pathway|ERK1 and ERK2 cascade|PERK-mediated unfolded protein response|double-stranded DNA binding|skeletal muscle cell differentiation|regulation of apoptotic process|cellular response to amino acid starvation|negative regulation of MAPK cascade|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|striated muscle tissue development|cellular protein modification process|extrinsic apoptotic signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|hexose biosynthetic process|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|protein phosphorylation|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|glucose metabolic process|transcription regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway via death domain receptors|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|gluconeogenesis|core promoter proximal region DNA binding|positive regulation of TRAIL-activated apoptotic signaling pathway|TRAIL-activated apoptotic signaling pathway|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09032 activating transcription factor 3[-] hsa05166 HTLV-I infection - Homo sapiens (human) 1:212565334-212620777 116 105 169 41 35 17 0.844968681668266 0.6951083454804 1.10989500770804 0.267585086969638 0.209179399157485 0.116053826065494 0.883324011618902 0.197606104064206 2.16031521662213 4.11923024633677e-10 9.74449285056561e-09 UP ENSG00000154370 TRIM11 tripartite motif containing 11 [Source:HGNC Symbol;Acc:HGNC:16281] GO:0040011|GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0040013|GO:0009892|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0040017|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0016874|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0016032|GO:0045087|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0045596|GO:0034641|GO:0006952|GO:0048524|GO:0046483|GO:0098542|GO:0043231|GO:0043169|GO:0046597|GO:0005737|GO:0009615|GO:0046598|GO:0046596|GO:0009890|GO:0019904|GO:0006139|GO:0008134|GO:0048525|GO:0019787|GO:0051607|GO:0048869|GO:0044249|GO:0019538|GO:0050792|GO:0031324|GO:0031323|GO:0051701|GO:0050768|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0010629|GO:0004842|GO:0051252|GO:0010721|GO:0019076|GO:0036211|GO:0019083|GO:0044267|GO:1903902|GO:0010467|GO:0007399|GO:0019058|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0051960|GO:1902186|GO:0061630|GO:0045892|GO:0046718|GO:0046782|GO:0032774|GO:2001141|GO:1902679|GO:0046914|GO:0032897|GO:0022008|GO:0030260|GO:0006464|GO:0050767|GO:0006351|GO:1902187|GO:0006355|GO:1903507|GO:0048699|GO:1903506|GO:0008270|GO:0032446|GO:0016567 locomotion|developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|negative regulation of locomotion|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|positive regulation of locomotion|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|ligase activity|regulation of developmental process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|viral process|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|negative regulation of cell differentiation|cellular nitrogen compound metabolic process|defense response|positive regulation of viral process|heterocycle metabolic process|defense response to other organism|intracellular membrane-bounded organelle|cation binding|negative regulation of viral entry into host cell|cytoplasm|response to virus|positive regulation of viral entry into host cell|regulation of viral entry into host cell|negative regulation of biosynthetic process|protein domain specific binding|nucleobase-containing compound metabolic process|transcription factor binding|negative regulation of viral process|ubiquitin-like protein transferase activity|defense response to virus|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of viral process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|interaction with host|negative regulation of neurogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|negative regulation of gene expression|ubiquitin-protein transferase activity|regulation of RNA metabolic process|negative regulation of cell development|viral release from host cell|protein modification process|viral transcription|cellular protein metabolic process|positive regulation of viral life cycle|gene expression|nervous system development|viral life cycle|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|regulation of nervous system development|regulation of viral release from host cell|ubiquitin protein ligase activity|negative regulation of transcription, DNA-templated|viral entry into host cell|regulation of viral transcription|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transition metal ion binding|negative regulation of viral transcription|neurogenesis|entry into host cell|cellular protein modification process|regulation of neurogenesis|transcription, DNA-templated|negative regulation of viral release from host cell|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|generation of neurons|regulation of nucleic acid-templated transcription|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 1:228393673-228406840 3214 3249 3098 1519 1555 997 19.0488708058003 17.5006047990631 16.5546095904969 8.06638266779 7.56174089567514 5.53793122062274 17.7013617317868 7.05535159469596 1.32707046369353 4.17550209131269e-10 9.86978934553041e-09 UP ENSG00000104897 SF3A2 splicing factor 3a subunit 2 [Source:HGNC Symbol;Acc:HGNC:10766] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0045595|GO:0006725|GO:0048468|GO:0051130|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0051128|GO:0022607|GO:0045597|GO:0043231|GO:0043169|GO:0030529|GO:0006139|GO:0030030|GO:0048869|GO:0022613|GO:0031175|GO:0031344|GO:0046872|GO:0003723|GO:0010720|GO:0030532|GO:0031346|GO:0022618|GO:0031981|GO:0050769|GO:0005681|GO:0005654|GO:0010467|GO:0007399|GO:0030154|GO:0016070|GO:0005634|GO:0051960|GO:0048666|GO:0030182|GO:0097525|GO:0010975|GO:0034622|GO:0006396|GO:0071010|GO:0016604|GO:0005684|GO:0006376|GO:0016071|GO:0046914|GO:0044822|GO:0022008|GO:0050767|GO:0010976|GO:0000245|GO:0071013|GO:0045666|GO:0016607|GO:0048699|GO:0000389|GO:0005686|GO:0006397|GO:0071004|GO:0008380|GO:0008270|GO:0045664|GO:0000375|GO:0000398 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|cell projection organization|cellular developmental process|ribonucleoprotein complex biogenesis|neuron projection development|regulation of cell projection organization|metal ion binding|RNA binding|positive regulation of cell development|small nuclear ribonucleoprotein complex|positive regulation of cell projection organization|ribonucleoprotein complex assembly|nuclear lumen|positive regulation of neurogenesis|spliceosomal complex|nucleoplasm|gene expression|nervous system development|cell differentiation|RNA metabolic process|nucleus|regulation of nervous system development|neuron development|neuron differentiation|spliceosomal snRNP complex|regulation of neuron projection development|cellular macromolecular complex assembly|RNA processing|prespliceosome|nuclear body|U2-type spliceosomal complex|mRNA splice site selection|mRNA metabolic process|transition metal ion binding|poly(A) RNA binding|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|spliceosomal complex assembly|catalytic step 2 spliceosome|positive regulation of neuron differentiation|nuclear speck|generation of neurons|mRNA 3'-splice site recognition|U2 snRNP|mRNA processing|U2-type prespliceosome|RNA splicing|zinc ion binding|regulation of neuron differentiation|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome K12826 splicing factor 3A subunit 2[-] hsa03040 Spliceosome - Homo sapiens (human) 19:2236504-2248679 1564 1529 1334 619 762 554 25.345351845348 22.5190004586911 19.4908862927703 8.98772814210395 10.1317428397428 8.41394880367284 22.4517461989365 9.1778065951732 1.29060634573292 4.25180459292361e-10 1.00421973352169e-08 UP ENSG00000156535 CD109 CD109 molecule [Source:HGNC Symbol;Acc:HGNC:21685] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0071704|GO:0009986|GO:0044237|GO:0023051|GO:0009653|GO:0071944|GO:0009605|GO:0023057|GO:0031224|GO:0005615|GO:0030234|GO:0050793|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0031225|GO:0042127|GO:0006949|GO:0004857|GO:0045595|GO:0009888|GO:0019838|GO:0007275|GO:0048513|GO:0090287|GO:0001942|GO:0009611|GO:0071559|GO:0009966|GO:0050673|GO:0010646|GO:0090288|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0019955|GO:0008285|GO:0050790|GO:0043086|GO:0048869|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0032268|GO:0045682|GO:0090101|GO:0007166|GO:0050431|GO:0043412|GO:0030097|GO:0030414|GO:0022405|GO:0036211|GO:0032269|GO:0071560|GO:0030856|GO:0042060|GO:0051346|GO:0070848|GO:0006508|GO:0050678|GO:0050680|GO:0043588|GO:0061045|GO:0060429|GO:0006796|GO:0044267|GO:0051174|GO:0071310|GO:0051246|GO:0030154|GO:0043616|GO:0042633|GO:0002521|GO:0004866|GO:0010466|GO:0010837|GO:0030855|GO:0030162|GO:0030216|GO:0071363|GO:0016310|GO:0052547|GO:0008544|GO:0045604|GO:0007179|GO:0030512|GO:0007167|GO:0072675|GO:0045861|GO:0030099|GO:0006464|GO:0017015|GO:0010839|GO:0098773|GO:0061041|GO:0045616|GO:0002573|GO:0006468|GO:0042325|GO:0001932|GO:0010951|GO:0042326|GO:0007178|GO:0001933|GO:0004867|GO:0052548|GO:0009913|GO:0030316|GO:0072674 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|organic substance metabolic process|cell surface|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cell periphery|response to external stimulus|negative regulation of signaling|intrinsic component of membrane|extracellular space|enzyme regulator activity|regulation of developmental process|immune system development|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|anchored component of membrane|regulation of cell proliferation|syncytium formation|enzyme inhibitor activity|regulation of cell differentiation|tissue development|growth factor binding|multicellular organism development|animal organ development|regulation of cellular response to growth factor stimulus|hair follicle development|response to wounding|response to transforming growth factor beta|regulation of signal transduction|epithelial cell proliferation|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|cytokine binding|negative regulation of cell proliferation|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of epidermis development|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|transforming growth factor beta binding|macromolecule modification|hemopoiesis|peptidase inhibitor activity|hair cycle process|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|regulation of epithelial cell differentiation|wound healing|negative regulation of hydrolase activity|response to growth factor|proteolysis|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|skin development|negative regulation of wound healing|epithelium development|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of protein metabolic process|cell differentiation|keratinocyte proliferation|hair cycle|leukocyte differentiation|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of keratinocyte proliferation|epithelial cell differentiation|regulation of proteolysis|keratinocyte differentiation|cellular response to growth factor stimulus|phosphorylation|regulation of peptidase activity|epidermis development|regulation of epidermal cell differentiation|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|osteoclast fusion|negative regulation of proteolysis|myeloid cell differentiation|cellular protein modification process|regulation of transforming growth factor beta receptor signaling pathway|negative regulation of keratinocyte proliferation|skin epidermis development|regulation of wound healing|regulation of keratinocyte differentiation|myeloid leukocyte differentiation|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of endopeptidase activity|negative regulation of phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|serine-type endopeptidase inhibitor activity|regulation of endopeptidase activity|epidermal cell differentiation|osteoclast differentiation|multinuclear osteoclast differentiation - - - - 6:73695785-73828316 450 573 1001 1917 2051 2411 2.14238531885516 2.47924717431449 4.29668829681274 8.17721247414439 8.01159648021604 10.7575063521028 2.9727735966608 8.98210510215441 -1.59524401032091 4.26829210158796e-10 1.00731693597476e-08 DOWN ENSG00000146757 ZNF92 zinc finger protein 92 [Source:HGNC Symbol;Acc:HGNC:13168] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0008270|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|zinc ion binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 7:65373799-65401135 488 488 431 179 217 151 3.59204672023705 3.26454362787738 2.86031629062115 1.18052236903821 1.31053662632724 1.04166668611266 3.23896887957853 1.17757522715937 1.45971537998605 4.28739548254917e-10 1.01102610376005e-08 UP ENSG00000197296 FITM2 fat storage-inducing transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:16135] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0010884|GO:0043227|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005789|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0044255|GO:0010883|GO:0019637|GO:0051128|GO:0043231|GO:0031227|GO:0005737|GO:0042592|GO:0019725|GO:0030176|GO:0006629|GO:0005783|GO:0019915|GO:0048869|GO:0016021|GO:0044249|GO:0010876|GO:0010890|GO:0031301|GO:0031323|GO:0006996|GO:0090207|GO:0000902|GO:0008654|GO:0046486|GO:0007010|GO:0048878|GO:0055082|GO:0006638|GO:0034389|GO:0022604|GO:0005739|GO:0006796|GO:0030730|GO:0008610|GO:0019216|GO:0046890|GO:0006644|GO:0010866|GO:0035356|GO:0055088|GO:0006639|GO:0055090|GO:0006641|GO:0019432|GO:0070328 developmental process|cell|membrane|cellular process|metabolic process|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|positive regulation of lipid storage|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|endoplasmic reticulum membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|cellular lipid metabolic process|regulation of lipid storage|organophosphate metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cytoplasm|homeostatic process|cellular homeostasis|integral component of endoplasmic reticulum membrane|lipid metabolic process|endoplasmic reticulum|lipid storage|cellular developmental process|integral component of membrane|cellular biosynthetic process|lipid localization|positive regulation of sequestering of triglyceride|integral component of organelle membrane|regulation of cellular metabolic process|organelle organization|regulation of triglyceride metabolic process|cell morphogenesis|phospholipid biosynthetic process|glycerolipid metabolic process|cytoskeleton organization|chemical homeostasis|cellular chemical homeostasis|neutral lipid metabolic process|lipid particle organization|regulation of cell morphogenesis|mitochondrion|phosphate-containing compound metabolic process|sequestering of triglyceride|lipid biosynthetic process|regulation of lipid metabolic process|regulation of lipid biosynthetic process|phospholipid metabolic process|regulation of triglyceride biosynthetic process|cellular triglyceride homeostasis|lipid homeostasis|acylglycerol metabolic process|acylglycerol homeostasis|triglyceride metabolic process|triglyceride biosynthetic process|triglyceride homeostasis - - - - 20:44302838-44311169 31 48 76 204 234 194 0.477015410662707 0.671261801130158 1.0543829573728 2.8125397224951 2.95430171818495 2.79770643648826 0.734220056388555 2.85484929238944 -1.95913015807035 4.33103221376253e-10 1.02051014766903e-08 DOWN ENSG00000168994 PXDC1 PX domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21361] GO:0005488|GO:0043167|GO:0008289|GO:0043168|GO:0005543|GO:0035091 binding|ion binding|lipid binding|anion binding|phospholipid binding|phosphatidylinositol binding - - - - 6:3722614-3752026 145 194 171 515 564 458 2.39199244043859 2.90852066309223 2.54331775276264 7.61194426861219 7.6337539341847 7.0808487144395 2.61461028543115 7.44218230574546 -1.50912980656099 4.34658417326952e-10 1.02336690779802e-08 DOWN ENSG00000108262 GIT1 G protein-coupled receptor kinase interacting ArfGAP 1 [Source:HGNC Symbol;Acc:HGNC:4272] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0030055|GO:0044877|GO:0050794|GO:0043167|GO:0023051|GO:0009653|GO:0016043|GO:0009605|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0006935|GO:0048468|GO:0022402|GO:0007275|GO:0051302|GO:0008047|GO:0005924|GO:0005912|GO:0043169|GO:0016234|GO:0005737|GO:0006928|GO:0032403|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0030030|GO:0051301|GO:0048869|GO:0000902|GO:0005829|GO:0031175|GO:0007186|GO:0005096|GO:0046872|GO:0007166|GO:0051345|GO:0008277|GO:0030695|GO:0000904|GO:0016235|GO:0032465|GO:0010564|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0000910|GO:0005925|GO:0048666|GO:0030182|GO:0007411|GO:0043087|GO:0061564|GO:0043547|GO:0007167|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699|GO:0007169|GO:0048013 locomotion|developmental process|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell-substrate junction|macromolecular complex binding|regulation of cellular process|ion binding|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|chemotaxis|cell development|cell cycle process|multicellular organism development|regulation of cell division|enzyme activator activity|cell-substrate adherens junction|adherens junction|cation binding|inclusion body|cytoplasm|movement of cell or subcellular component|protein complex binding|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cell projection organization|cell division|cellular developmental process|cell morphogenesis|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|GTPase activator activity|metal ion binding|cell surface receptor signaling pathway|positive regulation of hydrolase activity|regulation of G-protein coupled receptor protein signaling pathway|GTPase regulator activity|cell morphogenesis involved in differentiation|aggresome|regulation of cytokinesis|regulation of cell cycle process|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|cytokinesis|focal adhesion|neuron development|neuron differentiation|axon guidance|regulation of GTPase activity|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons|transmembrane receptor protein tyrosine kinase signaling pathway|ephrin receptor signaling pathway K05737 G protein-coupled receptor kinase interactor 1[-] hsa04144|hsa04810|hsa05120 Endocytosis - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) 17:29573469-29594054 2215 2407 2271 1044 1240 981 13.2187714084274 13.0549016347697 12.2193693413102 5.58233071662143 6.07165336057688 5.48675408407897 12.8310141281691 5.71357938709243 1.16716846225274 4.4314413431068e-10 1.04252363953594e-08 UP ENSG00000147872 PLIN2 perilipin 2 [Source:HGNC Symbol;Acc:HGNC:248] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0044255|GO:0006810|GO:0044281|GO:0043231|GO:0005737|GO:0042493|GO:0006629|GO:0005783|GO:0019915|GO:0010876|GO:0010033|GO:0005829|GO:0005811|GO:0006811|GO:0006869|GO:0014070|GO:0005634|GO:0006820|GO:0015711|GO:0015908|GO:0046942|GO:0015718|GO:0015909 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|cellular lipid metabolic process|transport|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|response to drug|lipid metabolic process|endoplasmic reticulum|lipid storage|lipid localization|response to organic substance|cytosol|lipid particle|ion transport|lipid transport|response to organic cyclic compound|nucleus|anion transport|organic anion transport|fatty acid transport|carboxylic acid transport|monocarboxylic acid transport|long-chain fatty acid transport - - - - 9:19108375-19149290 861 808 916 401 449 348 8.51333712450353 7.26086118663739 8.16594358636478 3.55253792276742 3.64259346431104 3.22481556866262 7.98004729916857 3.47331565191369 1.20008377003277 4.54631885858704e-10 1.06800192061574e-08 UP ENSG00000230124 ACBD6 acyl-CoA binding domain containing 6 [Source:HGNC Symbol;Acc:HGNC:23339] GO:0005623|GO:0005488|GO:0043167|GO:0048037|GO:0008289|GO:0005622|GO:0005515|GO:0043168|GO:0005737|GO:0050662|GO:0000062 cell|binding|ion binding|cofactor binding|lipid binding|intracellular|protein binding|anion binding|cytoplasm|coenzyme binding|fatty-acyl-CoA binding - - - - 1:180269653-180502954 239 299 314 785 882 672 2.05495120281072 2.3364450888902 2.43415270938837 6.04743772502079 6.22215638954713 5.41504700584761 2.2751830003631 5.89488037347184 -1.37347994584124 4.54689636598982e-10 1.06800192061574e-08 DOWN ENSG00000237187 NR2F1-AS1 NR2F1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:48622] - - - - - - 5:93409359-93585648 3 11 13 54 73 53 0.0144701588135913 0.0482164551392673 0.0565269858717125 0.233342728870593 0.288867106554905 0.239555983195028 0.0397378666081904 0.253921939540175 -2.67579872675564 4.565643728994e-10 1.07156232614298e-08 DOWN ENSG00000174238 PITPNA phosphatidylinositol transfer protein alpha [Source:HGNC Symbol;Acc:HGNC:9001] GO:0040011|GO:0032502|GO:0005215|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0043209|GO:0071704|GO:0009653|GO:0016043|GO:0043227|GO:0008289|GO:0009605|GO:0005622|GO:0048856|GO:0006935|GO:0048468|GO:0006810|GO:0007275|GO:0050877|GO:0031982|GO:0005737|GO:0006928|GO:0005319|GO:0006629|GO:0070062|GO:0030030|GO:0048869|GO:0010876|GO:0000902|GO:0031175|GO:0005548|GO:0000904|GO:0006811|GO:0007600|GO:0006869|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0048666|GO:0030182|GO:0015914|GO:0007411|GO:0050953|GO:0006820|GO:0015711|GO:0061564|GO:0008525|GO:0008526|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699|GO:0007601 locomotion|developmental process|transporter activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|myelin sheath|organic substance metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|lipid binding|response to external stimulus|intracellular|anatomical structure development|chemotaxis|cell development|transport|multicellular organism development|neurological system process|vesicle|cytoplasm|movement of cell or subcellular component|lipid transporter activity|lipid metabolic process|extracellular exosome|cell projection organization|cellular developmental process|lipid localization|cell morphogenesis|neuron projection development|phospholipid transporter activity|cell morphogenesis involved in differentiation|ion transport|sensory perception|lipid transport|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|neuron development|neuron differentiation|phospholipid transport|axon guidance|sensory perception of light stimulus|anion transport|organic anion transport|axon development|phosphatidylcholine transporter activity|phosphatidylinositol transporter activity|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons|visual perception - - - - 17:1517718-1562816 543 632 719 1580 1904 1468 4.2343821624958 4.47906909528031 5.05514841687208 11.0393946481711 12.1821924477051 10.7286598624528 4.58953322488273 11.3167489861097 -1.30204023016109 4.57583230072451e-10 1.07310995684077e-08 DOWN ENSG00000140526 ABHD2 abhydrolase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:18717] GO:0040011|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0040013|GO:0048523|GO:0050794|GO:0040012|GO:0006950|GO:0048870|GO:0016787|GO:0031224|GO:0016788|GO:0009611|GO:0006928|GO:0051270|GO:0016477|GO:0051271|GO:0016021|GO:2000145|GO:2000146|GO:0030334|GO:0030336|GO:0052689 locomotion|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|negative regulation of locomotion|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|response to stress|cell motility|hydrolase activity|intrinsic component of membrane|hydrolase activity, acting on ester bonds|response to wounding|movement of cell or subcellular component|regulation of cellular component movement|cell migration|negative regulation of cellular component movement|integral component of membrane|regulation of cell motility|negative regulation of cell motility|regulation of cell migration|negative regulation of cell migration|carboxylic ester hydrolase activity - - - - 15:89087459-89202360 1476 1837 2222 4653 4806 7466 8.57345836432593 9.6974811990918 11.6366530117623 24.2158923302372 22.9045364046155 40.6430859128878 9.96919752506001 29.2545048825802 -1.55310951745576 4.59018642854665e-10 1.07563128444138e-08 DOWN ENSG00000109089 CDR2L cerebellar degeneration-related protein 2-like [Source:HGNC Symbol;Acc:HGNC:29999] - - - - - - 17:74987632-75005800 1075 1240 1269 564 630 502 21.5051258851933 22.5442240601464 22.8880784532485 10.1090448597924 10.3405046298734 9.41165290381453 22.3124761328627 9.95373413116011 1.16454086833444 4.61064869712353e-10 1.07957887218765e-08 UP ENSG00000116678 LEPR leptin receptor [Source:HGNC Symbol;Acc:HGNC:6554] GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0000003|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0007631|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0071704|GO:0019953|GO:0044237|GO:0050795|GO:0038023|GO:0007155|GO:0071944|GO:0009058|GO:0031224|GO:0048589|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0042802|GO:0044262|GO:0016337|GO:1901360|GO:0007275|GO:0048513|GO:0070489|GO:2000505|GO:0015980|GO:0044281|GO:0035265|GO:0098609|GO:0004888|GO:0043235|GO:0005975|GO:0042592|GO:0001775|GO:0048771|GO:0009890|GO:0048871|GO:0046649|GO:0007154|GO:0044092|GO:0006629|GO:0060259|GO:0007165|GO:0009725|GO:0050790|GO:0006091|GO:0034103|GO:0043086|GO:0048869|GO:0016021|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0055114|GO:0006109|GO:0046850|GO:0007166|GO:0030097|GO:0004896|GO:0034097|GO:0030098|GO:0048878|GO:0006066|GO:0044321|GO:0046849|GO:0007159|GO:0005996|GO:0051346|GO:0098868|GO:0008202|GO:0006112|GO:0042110|GO:0097009|GO:0071310|GO:0030154|GO:0032870|GO:0016051|GO:0002521|GO:0019318|GO:0044320|GO:0019221|GO:0038021|GO:0030217|GO:0006111|GO:0070486|GO:0010906|GO:0016125|GO:0071345|GO:0045721|GO:0033500|GO:0042593|GO:0019319|GO:0033210|GO:0006006|GO:0008203|GO:0071593|GO:0006094 developmental process|growth|macromolecular complex|signal transducer activity|reproduction|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|feeding behavior|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|organic substance metabolic process|sexual reproduction|cellular metabolic process|regulation of behavior|signaling receptor activity|cell adhesion|cell periphery|biosynthetic process|intrinsic component of membrane|developmental growth|immune system development|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|identical protein binding|cellular carbohydrate metabolic process|single organismal cell-cell adhesion|organic cyclic compound metabolic process|multicellular organism development|animal organ development|T cell aggregation|regulation of energy homeostasis|energy derivation by oxidation of organic compounds|small molecule metabolic process|organ growth|cell-cell adhesion|transmembrane signaling receptor activity|receptor complex|carbohydrate metabolic process|homeostatic process|cell activation|tissue remodeling|negative regulation of biosynthetic process|multicellular organismal homeostasis|lymphocyte activation|cell communication|negative regulation of molecular function|lipid metabolic process|regulation of feeding behavior|signal transduction|response to hormone|regulation of catalytic activity|generation of precursor metabolites and energy|regulation of tissue remodeling|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|oxidation-reduction process|regulation of carbohydrate metabolic process|regulation of bone remodeling|cell surface receptor signaling pathway|hemopoiesis|cytokine receptor activity|response to cytokine|lymphocyte differentiation|chemical homeostasis|alcohol metabolic process|response to leptin|bone remodeling|leukocyte cell-cell adhesion|monosaccharide metabolic process|negative regulation of hydrolase activity|bone growth|steroid metabolic process|energy reserve metabolic process|T cell activation|energy homeostasis|cellular response to organic substance|cell differentiation|cellular response to hormone stimulus|carbohydrate biosynthetic process|leukocyte differentiation|hexose metabolic process|cellular response to leptin stimulus|cytokine-mediated signaling pathway|leptin receptor activity|T cell differentiation|regulation of gluconeogenesis|leukocyte aggregation|regulation of glucose metabolic process|sterol metabolic process|cellular response to cytokine stimulus|negative regulation of gluconeogenesis|carbohydrate homeostasis|glucose homeostasis|hexose biosynthetic process|leptin-mediated signaling pathway|glucose metabolic process|cholesterol metabolic process|lymphocyte aggregation|gluconeogenesis K05062 leptin receptor[-] hsa04080|hsa04060|hsa04630|hsa04932|hsa04152|hsa04920 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human) 1:65420652-65641559 50 40 137 340 429 837 0.239361848220496 0.17403167861145 0.591321027633437 1.45836387290141 1.68505496644116 3.75528898480237 0.334904851488461 2.29956927471498 -2.77954047924656 4.62172437354461e-10 1.08132413360345e-08 DOWN ENSG00000108055 SMC3 structural maintenance of chromosomes 3 [Source:HGNC Symbol;Acc:HGNC:2468] GO:0032502|GO:0031012|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0005604|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0005578|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0008280|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0045786|GO:0043231|GO:0005737|GO:0045502|GO:0032403|GO:0046983|GO:0009890|GO:0003682|GO:0006139|GO:0007154|GO:0007165|GO:0007126|GO:0007059|GO:0000166|GO:0051301|GO:0044249|GO:0007017|GO:0019827|GO:0019538|GO:0031324|GO:0031323|GO:0008278|GO:0006996|GO:0051276|GO:0005829|GO:0000819|GO:0034645|GO:0051053|GO:0035639|GO:1903047|GO:0043412|GO:0007010|GO:0046982|GO:0001883|GO:0016818|GO:0036211|GO:0000278|GO:0032549|GO:0031981|GO:0007062|GO:0030893|GO:0010564|GO:0005654|GO:0006259|GO:0016363|GO:0007051|GO:0005694|GO:0000228|GO:0044267|GO:0007067|GO:0017076|GO:0009059|GO:0034399|GO:0000226|GO:0036033|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0006974|GO:0010948|GO:0008156|GO:0034991|GO:0006260|GO:0000793|GO:0005524|GO:0007064|GO:0030554|GO:0032876|GO:0007052|GO:0000794|GO:0015630|GO:0042023|GO:0006275|GO:0000070|GO:0032875|GO:0000795|GO:0006464|GO:0016462|GO:0000800|GO:0000775|GO:0006261|GO:0017111|GO:0018193|GO:0043687|GO:0032446|GO:0018205|GO:0003774|GO:0016925|GO:0003777 developmental process|extracellular matrix|macromolecular complex|reproduction|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|basement membrane|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cohesin core heterodimer|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|dynein binding|protein complex binding|protein dimerization activity|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|meiotic nuclear division|chromosome segregation|nucleotide binding|cell division|cellular biosynthetic process|microtubule-based process|stem cell population maintenance|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cohesin complex|organelle organization|chromosome organization|cytosol|sister chromatid segregation|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|protein heterodimerization activity|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|mitotic cell cycle|ribonucleoside binding|nuclear lumen|sister chromatid cohesion|meiotic cohesin complex|regulation of cell cycle process|nucleoplasm|DNA metabolic process|nuclear matrix|spindle organization|chromosome|nuclear chromosome|cellular protein metabolic process|mitotic nuclear division|purine nucleotide binding|macromolecule biosynthetic process|nuclear periphery|microtubule cytoskeleton organization|mediator complex binding|cytoskeleton|spindle pole|nucleus|spindle|cellular response to DNA damage stimulus|negative regulation of cell cycle process|negative regulation of DNA replication|nuclear meiotic cohesin complex|DNA replication|condensed chromosome|ATP binding|mitotic sister chromatid cohesion|adenyl nucleotide binding|negative regulation of DNA endoreduplication|mitotic spindle organization|condensed nuclear chromosome|microtubule cytoskeleton|DNA endoreduplication|regulation of DNA replication|mitotic sister chromatid segregation|regulation of DNA endoreduplication|synaptonemal complex|cellular protein modification process|pyrophosphatase activity|lateral element|chromosome, centromeric region|DNA-dependent DNA replication|nucleoside-triphosphatase activity|peptidyl-amino acid modification|post-translational protein modification|protein modification by small protein conjugation|peptidyl-lysine modification|motor activity|protein sumoylation|microtubule motor activity K06669 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6)[-] hsa04110|hsa04114 Cell cycle - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human) 10:110567691-110604636 3680 4226 3752 1866 2001 1571 59.7182008265418 62.3258783395371 54.8953988288074 27.1311529330596 26.6424316751915 23.8926248192749 58.9798259982954 25.888736475842 1.1878970113147 4.65922340826048e-10 1.08924397517783e-08 UP ENSG00000261087 KB-1460A1.5 - - - - - - - 8:101166805-101169629 141 187 310 32 43 70 3.53059445409133 4.25548881891818 6.99846447155798 0.717919704497935 0.883403355928291 1.64267833997999 4.9281825815225 1.08133380013541 2.18824376500439 4.71943436299851e-10 1.10245691293394e-08 UP ENSG00000150756 FAM173B family with sequence similarity 173 member B [Source:HGNC Symbol;Acc:HGNC:27029] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 5:10226330-10249897 30 56 34 214 209 141 0.431842317743966 0.732618827111903 0.441267199742475 2.76008417386616 2.46845413995231 1.90221588990946 0.535242781532781 2.37691806790931 -2.15082683543047 4.85429556340367e-10 1.13307380570644e-08 DOWN ENSG00000204060 FOXO6 forkhead box O6 [Source:HGNC Symbol;Acc:HGNC:24814] GO:0032502|GO:0007610|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:0048468|GO:0051130|GO:1901360|GO:0007275|GO:0003676|GO:0050877|GO:0016358|GO:0034641|GO:0046483|GO:0051128|GO:0045597|GO:0043231|GO:0005737|GO:0000981|GO:0006139|GO:0060996|GO:0007611|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0060998|GO:0031175|GO:0003677|GO:0031344|GO:0010468|GO:0034645|GO:0050773|GO:0010720|GO:0051252|GO:0031346|GO:0007613|GO:0060999|GO:0050769|GO:0010467|GO:0007399|GO:0050890|GO:0009059|GO:0030154|GO:1900006|GO:0016070|GO:0005634|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0032774|GO:0043565|GO:2001141|GO:0022008|GO:0050767|GO:0010976|GO:0006351|GO:0006355|GO:0045666|GO:0006366|GO:0006357|GO:0048699|GO:1903506|GO:0045664 developmental process|behavior|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|neurological system process|dendrite development|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|dendritic spine development|learning or memory|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of dendritic spine development|neuron projection development|DNA binding|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of dendrite development|positive regulation of cell development|regulation of RNA metabolic process|positive regulation of cell projection organization|memory|positive regulation of dendritic spine development|positive regulation of neurogenesis|gene expression|nervous system development|cognition|macromolecule biosynthetic process|cell differentiation|positive regulation of dendrite development|RNA metabolic process|nucleus|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|regulation of neuron differentiation - - - - 1:41361922-41383590 32 22 48 129 156 187 0.58430731446543 0.365080187335965 0.790211602346027 2.11043919832924 2.33711135074353 3.20004794892672 0.579866368049141 2.54919949933316 -2.13625191227544 4.94239875660076e-10 1.15273728499655e-08 DOWN ENSG00000132622 HSPA12B heat shock protein family A (Hsp70) member 12B [Source:HGNC Symbol;Acc:HGNC:16193] GO:0005488|GO:0036094|GO:0097159|GO:0043167|GO:0005515|GO:0043168|GO:0001882|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005524|GO:0030554 binding|small molecule binding|organic cyclic compound binding|ion binding|protein binding|anion binding|nucleoside binding|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|ATP binding|adenyl nucleotide binding - - - - 20:3732667-3753111 50 69 49 13 9 12 1.09329541555056 1.37120688349727 0.966004459137049 0.254689033935959 0.161464161627029 0.245904006578986 1.14350225272829 0.220685734047325 2.37339393136629 5.03438667614644e-10 1.17327540850645e-08 UP ENSG00000088387 DOCK9 dedicator of cytokinesis 9 [Source:HGNC Symbol;Acc:HGNC:14132] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0009893|GO:0005622|GO:0005515|GO:0012505|GO:0005085|GO:0019222|GO:0050817|GO:0005737|GO:0009611|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0050878|GO:0005829|GO:0051345|GO:0007596|GO:0042060|GO:0007599|GO:0035556|GO:0043087|GO:0043547|GO:0007264 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|positive regulation of metabolic process|intracellular|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|regulation of metabolic process|coagulation|cytoplasm|response to wounding|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|regulation of body fluid levels|cytosol|positive regulation of hydrolase activity|blood coagulation|wound healing|hemostasis|intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase mediated signal transduction - - - - 13:98793487-99086625 385 417 894 1746 1899 2081 1.36250319309321 1.34119648747398 2.85251701127074 5.53628426031793 5.51403180898084 6.9020403868136 1.85207223061264 5.98411881870412 -1.6919984565476 5.05823280363433e-10 1.17791327706474e-08 DOWN ENSG00000137764 MAP2K5 mitogen-activated protein kinase kinase 5 [Source:HGNC Symbol;Acc:HGNC:6845] GO:0040011|GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0040013|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0043227|GO:0040008|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0008284|GO:0001818|GO:0051726|GO:0042127|GO:0007049|GO:0016337|GO:0006725|GO:1901360|GO:0001568|GO:0010941|GO:0034405|GO:0007275|GO:0010632|GO:0048513|GO:0034641|GO:0043168|GO:0030307|GO:0030155|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0060761|GO:0001817|GO:0098609|GO:0042228|GO:0043231|GO:0043169|GO:0005737|GO:0001816|GO:0006928|GO:0009966|GO:0048598|GO:0050673|GO:0009890|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0007162|GO:0001525|GO:0007154|GO:0044092|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0008219|GO:0051271|GO:0050790|GO:0000166|GO:0043086|GO:2000145|GO:0009967|GO:0044249|GO:0010633|GO:0019538|GO:0023014|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0051090|GO:0016525|GO:0042107|GO:0000165|GO:0050679|GO:1902533|GO:0032268|GO:0005829|GO:0098742|GO:0002040|GO:0071498|GO:0042036|GO:0010468|GO:0090132|GO:0034645|GO:0042089|GO:0046872|GO:0007166|GO:0035639|GO:0001944|GO:0043412|GO:0072358|GO:0034097|GO:0010629|GO:0032642|GO:0043069|GO:2001234|GO:0051252|GO:0001883|GO:0009790|GO:0070586|GO:0010628|GO:0030334|GO:0001667|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0007369|GO:0032549|GO:0032602|GO:0032717|GO:0022408|GO:0022407|GO:0031098|GO:0045765|GO:0007346|GO:0042035|GO:0051247|GO:0051346|GO:0070848|GO:0006508|GO:0043433|GO:0050678|GO:0016301|GO:0030336|GO:0034616|GO:0032270|GO:0012501|GO:0006796|GO:0034113|GO:1901342|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0017076|GO:0010594|GO:0031328|GO:0051246|GO:0010470|GO:0009059|GO:1902531|GO:0016070|GO:0072359|GO:0016773|GO:0005856|GO:0010557|GO:0010596|GO:0045414|GO:0005634|GO:0005819|GO:0043067|GO:0045415|GO:0032682|GO:0097190|GO:0045995|GO:0032637|GO:2001237|GO:0010466|GO:0045893|GO:0031401|GO:0043408|GO:0045892|GO:2000342|GO:0032774|GO:2001240|GO:0005524|GO:0030162|GO:2001141|GO:0097192|GO:0034115|GO:2001236|GO:0071363|GO:0030554|GO:2000341|GO:0043537|GO:0043535|GO:0016310|GO:0038179|GO:1902679|GO:0052547|GO:0002042|GO:0007167|GO:0015630|GO:0043410|GO:0010631|GO:0042981|GO:0032088|GO:0045861|GO:0043066|GO:0004672|GO:1903671|GO:0070375|GO:0006464|GO:0097191|GO:0043549|GO:0006351|GO:0071499|GO:0006915|GO:0006355|GO:0033674|GO:0048011|GO:0045944|GO:0006366|GO:0045859|GO:1903507|GO:0045860|GO:0043406|GO:0006357|GO:0043281|GO:0006468|GO:1903506|GO:0043405|GO:2001239|GO:0090051|GO:0042325|GO:0004713|GO:0001932|GO:0018193|GO:0010951|GO:0004674|GO:0001934|GO:0090049|GO:0000122|GO:0043154|GO:0043542|GO:0042327|GO:0007169|GO:0052548|GO:2000117|GO:0000187|GO:0071902|GO:0071900|GO:2000116|GO:0032147|GO:0018108|GO:0043534 locomotion|developmental process|growth|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|negative regulation of locomotion|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|membrane-bounded organelle|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|negative regulation of cytokine production|regulation of cell cycle|regulation of cell proliferation|cell cycle|single organismal cell-cell adhesion|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to fluid shear stress|multicellular organism development|regulation of epithelial cell migration|animal organ development|cellular nitrogen compound metabolic process|anion binding|positive regulation of cell growth|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|negative regulation of response to cytokine stimulus|regulation of cytokine production|cell-cell adhesion|interleukin-8 biosynthetic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cytokine production|movement of cell or subcellular component|regulation of signal transduction|embryonic morphogenesis|epithelial cell proliferation|negative regulation of biosynthetic process|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|negative regulation of cell adhesion|angiogenesis|cell communication|negative regulation of molecular function|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|cell death|negative regulation of cellular component movement|regulation of catalytic activity|nucleotide binding|negative regulation of catalytic activity|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|negative regulation of epithelial cell migration|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|regulation of sequence-specific DNA binding transcription factor activity|negative regulation of angiogenesis|cytokine metabolic process|MAPK cascade|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|cell-cell adhesion via plasma-membrane adhesion molecules|sprouting angiogenesis|cellular response to fluid shear stress|negative regulation of cytokine biosynthetic process|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|cytokine biosynthetic process|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|vasculature development|macromolecule modification|cardiovascular system development|response to cytokine|negative regulation of gene expression|regulation of chemokine production|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|purine nucleoside binding|embryo development|cell-cell adhesion involved in gastrulation|positive regulation of gene expression|regulation of cell migration|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|gastrulation|ribonucleoside binding|chemokine production|negative regulation of interleukin-8 production|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|stress-activated protein kinase signaling cascade|regulation of angiogenesis|regulation of mitotic cell cycle|regulation of cytokine biosynthetic process|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|proteolysis|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of epithelial cell proliferation|kinase activity|negative regulation of cell migration|response to laminar fluid shear stress|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|heterotypic cell-cell adhesion|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|purine nucleotide binding|regulation of endothelial cell migration|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|regulation of gastrulation|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|positive regulation of macromolecule biosynthetic process|negative regulation of endothelial cell migration|regulation of interleukin-8 biosynthetic process|nucleus|spindle|regulation of programmed cell death|negative regulation of interleukin-8 biosynthetic process|negative regulation of chemokine production|apoptotic signaling pathway|regulation of embryonic development|interleukin-8 production|negative regulation of extrinsic apoptotic signaling pathway|negative regulation of peptidase activity|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|negative regulation of chemokine (C-X-C motif) ligand 2 production|RNA biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|ATP binding|regulation of proteolysis|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of heterotypic cell-cell adhesion|regulation of extrinsic apoptotic signaling pathway|cellular response to growth factor stimulus|adenyl nucleotide binding|regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of blood vessel endothelial cell migration|regulation of blood vessel endothelial cell migration|phosphorylation|neurotrophin signaling pathway|negative regulation of RNA biosynthetic process|regulation of peptidase activity|cell migration involved in sprouting angiogenesis|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|positive regulation of MAPK cascade|epithelial cell migration|regulation of apoptotic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of proteolysis|negative regulation of apoptotic process|protein kinase activity|negative regulation of sprouting angiogenesis|ERK5 cascade|cellular protein modification process|extrinsic apoptotic signaling pathway|regulation of kinase activity|transcription, DNA-templated|cellular response to laminar fluid shear stress|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of transcription from RNA polymerase II promoter|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of cell migration involved in sprouting angiogenesis|regulation of phosphorylation|protein tyrosine kinase activity|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of endopeptidase activity|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|regulation of cell migration involved in sprouting angiogenesis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|endothelial cell migration|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|negative regulation of cysteine-type endopeptidase activity|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|regulation of cysteine-type endopeptidase activity|activation of protein kinase activity|peptidyl-tyrosine phosphorylation|blood vessel endothelial cell migration K04463 mitogen-activated protein kinase kinase 5[2.7.12.2] hsa04010|hsa04921|hsa04722|hsa04540 MAPK signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Gap junction - Homo sapiens (human) 15:67542709-67807123 49 58 79 204 233 212 0.436592799701767 0.469664129057316 0.634634838797048 1.62857351106058 1.70335305356604 1.77029108689209 0.513630589185377 1.7007392171729 -1.72735891273552 5.08418576430283e-10 1.18303415282538e-08 DOWN ENSG00000124201 ZNFX1 zinc finger, NFX1-type containing 1 [Source:HGNC Symbol;Acc:HGNC:29271] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0003723|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0046914|GO:0044822|GO:0006351|GO:0006355|GO:1903506|GO:0008270 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 20:49237946-49278426 4306 4881 3659 1844 2132 1673 20.0746656493681 20.6805982316279 15.3798096309208 7.70252296817165 8.15510365057469 7.30969114985511 18.7116911706389 7.72243925620048 1.27681143292481 5.13333362247312e-10 1.19354004645882e-08 UP ENSG00000139974 SLC38A6 solute carrier family 38 member 6 [Source:HGNC Symbol;Acc:HGNC:19863] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:1903825|GO:0006811|GO:0015075|GO:0034220|GO:0006820|GO:0015711|GO:0098656|GO:0008509|GO:0006812|GO:0046942|GO:0046943|GO:0006865|GO:0015171|GO:0003333|GO:0030001|GO:0008514|GO:0015672|GO:0006814 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|plasma membrane|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|organic acid transmembrane transport|ion transport|ion transmembrane transporter activity|ion transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|anion transmembrane transporter activity|cation transport|carboxylic acid transport|carboxylic acid transmembrane transporter activity|amino acid transport|amino acid transmembrane transporter activity|amino acid transmembrane transport|metal ion transport|organic anion transmembrane transporter activity|monovalent inorganic cation transport|sodium ion transport - - - - 14:60981114-61083733 85 83 109 269 333 299 0.623395647990054 0.553227215886017 0.720750730612486 1.76764171554548 2.00380355742281 2.05514836228116 0.632457864829519 1.94219787841648 -1.61864892154645 5.1508369018118e-10 1.19667770324272e-08 DOWN ENSG00000270574 RP11-171I2.2 - - - - - - - 2:178578790-178580906 9 9 17 65 74 56 0.300725175724107 0.273318915148557 0.512136754731819 1.94595896264249 2.02872884179321 1.75365864827824 0.362060281868161 1.90944881757131 -2.39885442281314 5.25294884672298e-10 1.21945205964283e-08 DOWN ENSG00000111700 SLCO1B3 solute carrier organic anion transporter family member 1B3 [Source:HGNC Symbol;Acc:HGNC:10961] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0022857|GO:0071704|GO:0044237|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0016323|GO:0006810|GO:1901360|GO:0006082|GO:0044281|GO:0005887|GO:0022891|GO:0005319|GO:0031226|GO:0055085|GO:0006629|GO:0016021|GO:0010876|GO:0015125|GO:0006811|GO:0015075|GO:0006869|GO:0008202|GO:0008206|GO:0015347|GO:0006820|GO:0015711|GO:0015721|GO:0008509|GO:0046942|GO:0046943|GO:0019752|GO:0015718|GO:0043252|GO:0032787|GO:0008514|GO:0008028 transporter activity|cell|membrane|cellular process|metabolic process|binding|transmembrane transporter activity|organic substance metabolic process|cellular metabolic process|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|basolateral plasma membrane|transport|organic cyclic compound metabolic process|organic acid metabolic process|small molecule metabolic process|integral component of plasma membrane|substrate-specific transmembrane transporter activity|lipid transporter activity|intrinsic component of plasma membrane|transmembrane transport|lipid metabolic process|integral component of membrane|lipid localization|bile acid transmembrane transporter activity|ion transport|ion transmembrane transporter activity|lipid transport|steroid metabolic process|bile acid metabolic process|sodium-independent organic anion transmembrane transporter activity|anion transport|organic anion transport|bile acid and bile salt transport|anion transmembrane transporter activity|carboxylic acid transport|carboxylic acid transmembrane transporter activity|carboxylic acid metabolic process|monocarboxylic acid transport|sodium-independent organic anion transport|monocarboxylic acid metabolic process|organic anion transmembrane transporter activity|monocarboxylic acid transmembrane transporter activity K05043 solute carrier organic anion transporter family, member 1B[-] hsa04976 Bile secretion - Homo sapiens (human) 12:20810702-20916911 50 54 148 373 474 363 0.734692702390122 0.721128855893177 1.96071555922282 4.91073048290378 5.71460596589129 4.99891104951785 1.13884570583537 5.20808249943764 -2.19318000219914 5.28741964912153e-10 1.22650059211246e-08 DOWN ENSG00000151718 WWC2 WW and C2 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24148] GO:0032502|GO:0040007|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0032947|GO:0044237|GO:0023051|GO:0045926|GO:0040008|GO:0023057|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046620|GO:0046483|GO:0046621|GO:0035265|GO:0019899|GO:0005737|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0048638|GO:0048640|GO:0044249|GO:0031324|GO:0031323|GO:0005829|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0019900|GO:0035556|GO:0010467|GO:1902532|GO:0009059|GO:1902531|GO:0016070|GO:0045892|GO:0032774|GO:0035331|GO:2001141|GO:1902679|GO:0035329|GO:0035330|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 developmental process|growth|structural molecule activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|protein complex scaffold|cellular metabolic process|regulation of signaling|negative regulation of growth|regulation of growth|negative regulation of signaling|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|regulation of organ growth|heterocycle metabolic process|negative regulation of organ growth|organ growth|enzyme binding|cytoplasm|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|regulation of developmental growth|negative regulation of developmental growth|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|kinase binding|intracellular signal transduction|gene expression|negative regulation of intracellular signal transduction|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|negative regulation of hippo signaling|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|hippo signaling|regulation of hippo signaling|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 4:183099293-183320777 195 289 518 1037 1194 1102 0.615541713325303 0.829089237605826 1.47423638742019 2.93291677785586 3.09239864523255 3.26012131660483 0.97295577945044 3.09514557989775 -1.6695611265183 5.3418823091734e-10 1.23817200666198e-08 DOWN ENSG00000164615 CAMLG calcium modulating ligand [Source:HGNC Symbol;Acc:HGNC:1471] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016032|GO:0006952|GO:0043231|GO:0001881|GO:0005737|GO:0050839|GO:0007154|GO:0007165|GO:0005783|GO:0016021|GO:0007166|GO:0043112|GO:0007167|GO:0007169|GO:0038127|GO:0007173 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|viral process|defense response|intracellular membrane-bounded organelle|receptor recycling|cytoplasm|cell adhesion molecule binding|cell communication|signal transduction|endoplasmic reticulum|integral component of membrane|cell surface receptor signaling pathway|receptor metabolic process|enzyme linked receptor protein signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 5:134738501-134752160 1360 1373 1555 548 602 763 31.5416889685343 28.9398547634544 32.5155085387772 11.3873944592553 11.455393919691 16.5843836822082 30.9990174235886 13.1423906870515 1.23799475187224 5.36858908186299e-10 1.24339688479393e-08 UP ENSG00000116748 AMPD1 adenosine monophosphate deaminase 1 [Source:HGNC Symbol;Acc:HGNC:468] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0009058|GO:0019239|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0043169|GO:0005737|GO:0016810|GO:0006139|GO:0055086|GO:0008092|GO:0044249|GO:0010033|GO:0005829|GO:0046872|GO:0019693|GO:0017022|GO:0003876|GO:0006796|GO:1901137|GO:0016814|GO:0043101|GO:0032036|GO:0009124|GO:0009259|GO:0009117|GO:0046390|GO:0006163|GO:0006144|GO:0009165|GO:0006164|GO:0032261|GO:0009156|GO:0009152|GO:0046040|GO:0009168|GO:0032264|GO:0006188 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|biosynthetic process|deaminase activity|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|cation binding|cytoplasm|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cytoskeletal protein binding|cellular biosynthetic process|response to organic substance|cytosol|metal ion binding|ribose phosphate metabolic process|myosin binding|AMP deaminase activity|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|purine-containing compound salvage|myosin heavy chain binding|nucleoside monophosphate biosynthetic process|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|purine nucleotide metabolic process|purine nucleobase metabolic process|nucleotide biosynthetic process|purine nucleotide biosynthetic process|purine nucleotide salvage|ribonucleoside monophosphate biosynthetic process|purine ribonucleotide biosynthetic process|IMP metabolic process|purine ribonucleoside monophosphate biosynthetic process|IMP salvage|IMP biosynthetic process K01490 AMP deaminase[3.5.4.6] hsa01100|hsa00230 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human) 1:114673098-114695618 25 28 14 1 1 1 0.591253248120185 0.601820280245385 0.298526488784349 0.0211798039120067 0.0194126471361927 0.02216173366022 0.49720000571664 0.0209180615694731 4.57100524144688 5.46906139037352e-10 1.26568495153652e-08 UP ENSG00000134330 IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog [Source:HGNC Symbol;Acc:HGNC:27696] GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0071704|GO:0009056|GO:0043227|GO:0016787|GO:0016788|GO:0031982|GO:0006629|GO:0070062|GO:0016042 extracellular region|metabolic process|catalytic activity|extracellular vesicle|organic substance metabolic process|catabolic process|membrane-bounded organelle|hydrolase activity|hydrolase activity, acting on ester bonds|vesicle|lipid metabolic process|extracellular exosome|lipid catabolic process - - - - 2:9473658-9496543 100 137 171 421 480 378 0.665508288602972 0.828618949053569 1.02603692951794 2.5103405055417 2.6209726334801 2.35762395395103 0.840054722391494 2.49631236432428 -1.57124325503716 5.47647229775898e-10 1.26641831121066e-08 DOWN ENSG00000138166 DUSP5 dual specificity phosphatase 5 [Source:HGNC Symbol;Acc:HGNC:3071] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0016787|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0006935|GO:0045087|GO:0009888|GO:0048468|GO:0007275|GO:0016788|GO:0006952|GO:0031325|GO:0043231|GO:0010243|GO:0006928|GO:0009966|GO:0048598|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0001704|GO:0044092|GO:0007165|GO:0009968|GO:0009725|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0007166|GO:0043412|GO:1901652|GO:0007492|GO:0000904|GO:0009790|GO:0071417|GO:0051347|GO:0036211|GO:0032269|GO:0007369|GO:0031981|GO:0043434|GO:0044344|GO:0001706|GO:0051247|GO:0070848|GO:0005654|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:1902532|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0005634|GO:0042578|GO:0048666|GO:0030182|GO:0007411|GO:0016311|GO:0031401|GO:0008543|GO:1901653|GO:0043408|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0007167|GO:0071375|GO:0043410|GO:0016791|GO:0043409|GO:0033673|GO:0032868|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0006470|GO:0000186|GO:0007265|GO:0045859|GO:0045860|GO:0043406|GO:0006469|GO:0007409|GO:0006468|GO:0043407|GO:0048699|GO:0043405|GO:0042325|GO:0004721|GO:0001932|GO:0032869|GO:0042326|GO:0038093|GO:0001934|GO:0001933|GO:0042327|GO:0007169|GO:0048010|GO:0035335|GO:0000187|GO:0038095|GO:0071901|GO:0071902|GO:0000188|GO:0008138|GO:0033549|GO:0071900|GO:0004725|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0017017 locomotion|developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|intracellular|regulation of immune system process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|chemotaxis|innate immune response|tissue development|cell development|multicellular organism development|hydrolase activity, acting on ester bonds|defense response|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|response to organonitrogen compound|movement of cell or subcellular component|regulation of signal transduction|embryonic morphogenesis|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|formation of primary germ layer|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|response to hormone|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|cell surface receptor signaling pathway|macromolecule modification|response to peptide|endoderm development|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|gastrulation|nuclear lumen|response to peptide hormone|cellular response to fibroblast growth factor stimulus|endoderm formation|positive regulation of protein metabolic process|response to growth factor|nucleoplasm|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|nucleus|phosphoric ester hydrolase activity|neuron development|neuron differentiation|axon guidance|dephosphorylation|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular response to peptide|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|phosphatase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|response to insulin|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|protein dephosphorylation|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|negative regulation of protein kinase activity|axonogenesis|protein phosphorylation|negative regulation of MAP kinase activity|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|cellular response to insulin stimulus|negative regulation of phosphorylation|Fc receptor signaling pathway|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|peptidyl-tyrosine dephosphorylation|activation of MAPK activity|Fc-epsilon receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|inactivation of MAPK activity|protein tyrosine/serine/threonine phosphatase activity|MAP kinase phosphatase activity|regulation of protein serine/threonine kinase activity|protein tyrosine phosphatase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|MAP kinase tyrosine/serine/threonine phosphatase activity K04459 dual specificity MAP kinase phosphatase[3.1.3.48] hsa04010 MAPK signaling pathway - Homo sapiens (human) 10:110497838-110511544 2788 2867 4161 1193 1363 1690 62.4886937612269 58.4004778305758 84.0854137844465 23.9578024368118 25.0652737149238 35.4996872745323 68.3248617920831 28.1742544754226 1.27803320099892 5.6640933701627e-10 1.3087913581489e-08 UP ENSG00000120254 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like [Source:HGNC Symbol;Acc:HGNC:21055] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0042802|GO:0006575|GO:0035239|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0006082|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0009887|GO:0021915|GO:0048729|GO:0046983|GO:0048598|GO:0048568|GO:0051186|GO:0035148|GO:0000166|GO:0006730|GO:0044249|GO:0055114|GO:0048705|GO:0004329|GO:0002009|GO:0035639|GO:0001883|GO:0035999|GO:0009790|GO:0072175|GO:0032549|GO:0042558|GO:0016331|GO:0008652|GO:0005759|GO:0005739|GO:0001841|GO:0060429|GO:0043603|GO:0048562|GO:0007399|GO:0060562|GO:0048701|GO:0017076|GO:0006760|GO:0001501|GO:0060606|GO:0048702|GO:0048703|GO:0042803|GO:0006766|GO:0048706|GO:0009792|GO:0042559|GO:0001843|GO:0005524|GO:0001838|GO:0046653|GO:0046655|GO:0030554|GO:0009108|GO:0004488|GO:0019752|GO:0048704|GO:0009396|GO:0006767|GO:0043648|GO:0043009|GO:0032787|GO:0015942 developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|identical protein binding|cellular modified amino acid metabolic process|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|organ morphogenesis|neural tube development|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|embryonic organ development|cofactor metabolic process|tube formation|nucleotide binding|one-carbon metabolic process|cellular biosynthetic process|oxidation-reduction process|skeletal system morphogenesis|formate-tetrahydrofolate ligase activity|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|purine nucleoside binding|tetrahydrofolate interconversion|embryo development|epithelial tube formation|ribonucleoside binding|pteridine-containing compound metabolic process|morphogenesis of embryonic epithelium|cellular amino acid biosynthetic process|mitochondrial matrix|mitochondrion|neural tube formation|epithelium development|cellular amide metabolic process|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|embryonic cranial skeleton morphogenesis|purine nucleotide binding|folic acid-containing compound metabolic process|skeletal system development|tube closure|embryonic neurocranium morphogenesis|embryonic viscerocranium morphogenesis|protein homodimerization activity|vitamin metabolic process|embryonic skeletal system development|embryo development ending in birth or egg hatching|pteridine-containing compound biosynthetic process|neural tube closure|ATP binding|embryonic epithelial tube formation|tetrahydrofolate metabolic process|folic acid metabolic process|adenyl nucleotide binding|coenzyme biosynthetic process|methylenetetrahydrofolate dehydrogenase (NADP+) activity|carboxylic acid metabolic process|embryonic skeletal system morphogenesis|folic acid-containing compound biosynthetic process|water-soluble vitamin metabolic process|dicarboxylic acid metabolic process|chordate embryonic development|monocarboxylic acid metabolic process|formate metabolic process K13402 monofunctional C1-tetrahydrofolate synthase, mitochondrial[6.3.4.3] hsa01100|hsa00670 Metabolic pathways - Homo sapiens (human)|One carbon pool by folate - Homo sapiens (human) 6:150865549-151101887 228 184 306 833 901 575 2.21781920003019 1.62663140574103 2.68365648022063 7.25996795526156 7.19092642603348 5.24190026556865 2.17603569533062 6.5642648822879 -1.59293123337814 5.74356937972891e-10 1.32612931370786e-08 DOWN ENSG00000103160 HSDL1 hydroxysteroid dehydrogenase like 1 [Source:HGNC Symbol;Acc:HGNC:16475] GO:0005623|GO:0008152|GO:0003824|GO:0016491|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0055114|GO:0005739 cell|metabolic process|catalytic activity|oxidoreductase activity|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|oxidation-reduction process|mitochondrion - - - - 16:84122146-84145192 664 753 860 269 333 392 4.96661440297084 5.11879345876207 5.79969578108757 1.80278146837646 2.04363807881389 2.74793866538902 5.29503454760683 2.19811940419312 1.2683703400032 5.77189064079063e-10 1.33163850997035e-08 UP ENSG00000130939 UBE4B ubiquitination factor E4B [Source:HGNC Symbol;Acc:HGNC:12500] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0007507|GO:0009888|GO:0048468|GO:0009314|GO:0007275|GO:0048513|GO:0043168|GO:0001882|GO:0033554|GO:0061061|GO:0043231|GO:0019899|GO:0005737|GO:0009887|GO:0048729|GO:0007154|GO:0061383|GO:0007165|GO:0008219|GO:0019787|GO:0000166|GO:0030030|GO:0000151|GO:0048869|GO:0019538|GO:0003205|GO:0031175|GO:0035639|GO:0003208|GO:0043412|GO:0072358|GO:0030163|GO:0004842|GO:0048738|GO:0001883|GO:0051117|GO:0003007|GO:0044265|GO:0036211|GO:0060537|GO:0032549|GO:0003231|GO:1990234|GO:0006508|GO:0012501|GO:0044267|GO:0007399|GO:0017076|GO:0060415|GO:0030154|GO:0007517|GO:0072359|GO:0034976|GO:0005634|GO:0009416|GO:0061384|GO:0097190|GO:0048644|GO:0048666|GO:0030182|GO:0044257|GO:0061630|GO:0009411|GO:0010498|GO:0005524|GO:0030554|GO:0008626|GO:0051603|GO:0003222|GO:0003229|GO:0055008|GO:0014706|GO:0022008|GO:0006464|GO:0055010|GO:0006915|GO:0019941|GO:0048699|GO:0034450|GO:0043161|GO:0032446|GO:0006511|GO:0042787|GO:0016567|GO:0051865|GO:0006513|GO:0000209 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|ligase activity|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|heart development|tissue development|cell development|response to radiation|multicellular organism development|animal organ development|anion binding|nucleoside binding|cellular response to stress|muscle structure development|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|organ morphogenesis|tissue morphogenesis|cell communication|trabecula morphogenesis|signal transduction|cell death|ubiquitin-like protein transferase activity|nucleotide binding|cell projection organization|ubiquitin ligase complex|cellular developmental process|protein metabolic process|cardiac chamber development|neuron projection development|purine ribonucleoside triphosphate binding|cardiac ventricle morphogenesis|macromolecule modification|cardiovascular system development|protein catabolic process|ubiquitin-protein transferase activity|cardiac muscle tissue development|purine nucleoside binding|ATPase binding|heart morphogenesis|cellular macromolecule catabolic process|protein modification process|muscle tissue development|ribonucleoside binding|cardiac ventricle development|transferase complex|proteolysis|programmed cell death|cellular protein metabolic process|nervous system development|purine nucleotide binding|muscle tissue morphogenesis|cell differentiation|muscle organ development|circulatory system development|response to endoplasmic reticulum stress|nucleus|response to light stimulus|heart trabecula morphogenesis|apoptotic signaling pathway|muscle organ morphogenesis|neuron development|neuron differentiation|cellular protein catabolic process|ubiquitin protein ligase activity|response to UV|proteasomal protein catabolic process|ATP binding|adenyl nucleotide binding|granzyme-mediated apoptotic signaling pathway|proteolysis involved in cellular protein catabolic process|ventricular trabecula myocardium morphogenesis|ventricular cardiac muscle tissue development|cardiac muscle tissue morphogenesis|striated muscle tissue development|neurogenesis|cellular protein modification process|ventricular cardiac muscle tissue morphogenesis|apoptotic process|modification-dependent protein catabolic process|generation of neurons|ubiquitin-ubiquitin ligase activity|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein autoubiquitination|protein monoubiquitination|protein polyubiquitination K10597 ubiquitin conjugation factor E4 B[2.3.2.27] hsa04141|hsa04120 Protein processing in endoplasmic reticulum - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human) 1:10032832-10181239 420 474 574 1199 1208 1389 2.65097598984172 2.71903649815247 3.26650016678515 6.78068257394655 6.25592020157968 8.21651334672226 2.87883755159311 7.0843720407495 -1.2991535960977 5.8054571573186e-10 1.33834840134818e-08 DOWN ENSG00000248905 FMN1 formin 1 [Source:HGNC Symbol;Acc:HGNC:3768] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0044877|GO:0050794|GO:0043229|GO:0044089|GO:0071704|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0072033|GO:0035239|GO:0001822|GO:0009888|GO:0048468|GO:0035295|GO:0051130|GO:0005884|GO:0007275|GO:0048513|GO:0032535|GO:0072028|GO:0016358|GO:0030155|GO:0005912|GO:1901890|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0032970|GO:0009887|GO:0032403|GO:1901888|GO:0031589|GO:0048729|GO:0072006|GO:0019904|GO:0045785|GO:0008092|GO:0030030|GO:0048869|GO:0030029|GO:0031334|GO:0043254|GO:0006996|GO:0060560|GO:0015631|GO:0000902|GO:0031175|GO:0060677|GO:0048705|GO:0045216|GO:0032956|GO:0002009|GO:0007010|GO:0072164|GO:0001655|GO:0072273|GO:0072210|GO:0048813|GO:0017124|GO:0003779|GO:0000904|GO:0008017|GO:0001656|GO:0007160|GO:0072001|GO:0034329|GO:0010810|GO:0072077|GO:0006461|GO:0061326|GO:0030036|GO:0060993|GO:0060429|GO:0072073|GO:0032273|GO:0033043|GO:0035108|GO:0010467|GO:0032990|GO:0007399|GO:0060562|GO:1903393|GO:0051894|GO:0010811|GO:0030154|GO:0001501|GO:0030832|GO:0048858|GO:0001823|GO:0060173|GO:0072092|GO:0005856|GO:0005634|GO:0010638|GO:0048666|GO:0030182|GO:0015629|GO:0034622|GO:0001657|GO:0030838|GO:0034332|GO:0072078|GO:0043623|GO:0072163|GO:0008064|GO:0051493|GO:0061333|GO:0001952|GO:0007044|GO:0015630|GO:0001954|GO:0072080|GO:0048041|GO:0035136|GO:0022008|GO:0048667|GO:0051893|GO:0003338|GO:0007015|GO:0051495|GO:0048812|GO:0072283|GO:0035137|GO:0030833|GO:0034333|GO:0051125|GO:0051258|GO:0048699|GO:0045010|GO:0060675|GO:0008154|GO:0051127|GO:0030041 developmental process|growth|cell|membrane|cellular process|metabolic process|cell junction|binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|organic substance metabolic process|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|renal vesicle formation|tube morphogenesis|kidney development|tissue development|cell development|tube development|positive regulation of cellular component organization|actin filament|multicellular organism development|animal organ development|regulation of cellular component size|nephron morphogenesis|dendrite development|regulation of cell adhesion|adherens junction|positive regulation of cell junction assembly|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|regulation of actin filament-based process|organ morphogenesis|protein complex binding|regulation of cell junction assembly|cell-substrate adhesion|tissue morphogenesis|nephron development|protein domain specific binding|positive regulation of cell adhesion|cytoskeletal protein binding|cell projection organization|cellular developmental process|actin filament-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|organelle organization|developmental growth involved in morphogenesis|tubulin binding|cell morphogenesis|neuron projection development|ureteric bud elongation|skeletal system morphogenesis|cell-cell junction organization|regulation of actin cytoskeleton organization|morphogenesis of an epithelium|cytoskeleton organization|mesonephric tubule development|urogenital system development|metanephric nephron morphogenesis|metanephric nephron development|dendrite morphogenesis|SH3 domain binding|actin binding|cell morphogenesis involved in differentiation|microtubule binding|metanephros development|cell-matrix adhesion|renal system development|cell junction assembly|regulation of cell-substrate adhesion|renal vesicle morphogenesis|protein complex assembly|renal tubule development|actin cytoskeleton organization|kidney morphogenesis|epithelium development|kidney epithelium development|positive regulation of protein polymerization|regulation of organelle organization|limb morphogenesis|gene expression|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|positive regulation of adherens junction organization|positive regulation of focal adhesion assembly|positive regulation of cell-substrate adhesion|cell differentiation|skeletal system development|regulation of actin filament length|cell projection morphogenesis|mesonephros development|limb development|ureteric bud invasion|cytoskeleton|nucleus|positive regulation of organelle organization|neuron development|neuron differentiation|actin cytoskeleton|cellular macromolecular complex assembly|ureteric bud development|positive regulation of actin filament polymerization|adherens junction organization|nephron tubule morphogenesis|cellular protein complex assembly|mesonephric epithelium development|regulation of actin polymerization or depolymerization|regulation of cytoskeleton organization|renal tubule morphogenesis|regulation of cell-matrix adhesion|cell-substrate junction assembly|microtubule cytoskeleton|positive regulation of cell-matrix adhesion|nephron tubule development|focal adhesion assembly|forelimb morphogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of focal adhesion assembly|metanephros morphogenesis|actin filament organization|positive regulation of cytoskeleton organization|neuron projection morphogenesis|metanephric renal vesicle morphogenesis|hindlimb morphogenesis|regulation of actin filament polymerization|adherens junction assembly|regulation of actin nucleation|protein polymerization|generation of neurons|actin nucleation|ureteric bud morphogenesis|actin polymerization or depolymerization|positive regulation of actin nucleation|actin filament polymerization - - - - 15:32765545-33194733 46 58 99 234 259 287 0.0897423028714598 0.102836988267032 0.174137025671308 0.409029912413894 0.414580681594869 0.524750578987224 0.122238772269933 0.449453724331996 -1.87847062522844 5.98298536830315e-10 1.37821022519539e-08 DOWN ENSG00000115216 NRBP1 nuclear receptor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:7993] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0043227|GO:0071944|GO:0031252|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0042802|GO:0006725|GO:0006810|GO:1901360|GO:0005938|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0046483|GO:0043231|GO:0005737|GO:0030027|GO:0046983|GO:0006139|GO:0051649|GO:0000166|GO:0044249|GO:0019538|GO:0016192|GO:0034645|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0046907|GO:0032549|GO:0031981|GO:0048471|GO:0005654|GO:0016301|GO:0006796|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0016070|GO:0016773|GO:0005634|GO:0042803|GO:0032774|GO:0005524|GO:0030554|GO:0016310|GO:0048193|GO:0004672|GO:0006464|GO:0006351|GO:0006366|GO:0006352|GO:0006468|GO:0006888|GO:0006367 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|membrane-bounded organelle|cell periphery|cell leading edge|biosynthetic process|intracellular|protein binding|endomembrane system|transferase activity|identical protein binding|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cell cortex|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|lamellipodium|protein dimerization activity|nucleobase-containing compound metabolic process|establishment of localization in cell|nucleotide binding|cellular biosynthetic process|protein metabolic process|vesicle-mediated transport|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|intracellular transport|ribonucleoside binding|nuclear lumen|perinuclear region of cytoplasm|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|protein homodimerization activity|RNA biosynthetic process|ATP binding|adenyl nucleotide binding|phosphorylation|Golgi vesicle transport|protein kinase activity|cellular protein modification process|transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|protein phosphorylation|ER to Golgi vesicle-mediated transport|transcription initiation from RNA polymerase II promoter - - - - 2:27427790-27442259 4277 4469 3680 1923 2026 1405 42.7016978378183 40.5505079057041 33.1259219827404 17.2021515791484 16.5963727631518 13.1465318329232 38.7927092420876 15.6483520584078 1.30977480200957 6.08404839459339e-10 1.40041002908397e-08 UP ENSG00000144504 ANKMY1 ankyrin repeat and MYND domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20987] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872 binding|ion binding|protein binding|cation binding|metal ion binding - - - - 2:240479422-240569209 70 86 103 328 287 256 0.240600009194278 0.268644702565596 0.319192054653894 1.01011731558354 0.809375085978689 0.824648509193775 0.276145588804589 0.881380303585335 -1.67433557498405 6.09811129464388e-10 1.40256559776809e-08 DOWN ENSG00000085662 AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) [Source:HGNC Symbol;Acc:HGNC:381] GO:0032502|GO:0009055|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0043218|GO:0043220|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0043209|GO:0044702|GO:0071704|GO:0009628|GO:0044237|GO:0042445|GO:0023051|GO:0005911|GO:0043227|GO:0032504|GO:0009058|GO:0005615|GO:0005622|GO:0048856|GO:0048609|GO:0008284|GO:0044262|GO:0042127|GO:0006725|GO:0001822|GO:0035295|GO:1901360|GO:0007275|GO:0048513|GO:0009414|GO:0044281|GO:0031982|GO:0033554|GO:0016614|GO:0043231|GO:0010243|GO:0005737|GO:0005975|GO:0042592|GO:0009966|GO:0016903|GO:0030638|GO:0051186|GO:0060135|GO:0006979|GO:0048871|GO:0010646|GO:0032838|GO:0007154|GO:0007565|GO:0006629|GO:0007165|GO:0008207|GO:0070062|GO:0042180|GO:0042446|GO:0009725|GO:0097386|GO:0033010|GO:0010817|GO:0010035|GO:0009967|GO:0044249|GO:0010033|GO:0072044|GO:0055114|GO:1902533|GO:0005829|GO:0043795|GO:0048660|GO:0042542|GO:0001655|GO:0044597|GO:0001894|GO:0006066|GO:0097066|GO:1901652|GO:0048659|GO:0005773|GO:0071417|GO:0072061|GO:0048661|GO:0072001|GO:0006700|GO:0016616|GO:0031981|GO:0031098|GO:0034599|GO:0044598|GO:0005996|GO:0048471|GO:0097454|GO:0005654|GO:0018958|GO:0008202|GO:0000302|GO:0035556|GO:0008610|GO:1901661|GO:0071310|GO:0005902|GO:1902531|GO:0006584|GO:0005634|GO:0016051|GO:0016137|GO:0006060|GO:0019318|GO:1901653|GO:0000323|GO:0018931|GO:0006694|GO:0042415|GO:0097238|GO:0004033|GO:0051595|GO:0034614|GO:0070301|GO:0009712|GO:0008106|GO:0007259|GO:0019319|GO:0005764|GO:0046425|GO:0006000|GO:0046427|GO:0006061|GO:0046370|GO:0042629|GO:0004032 developmental process|electron carrier activity|reproduction|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|compact myelin|Schmidt-Lanterman incisure|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|myelin sheath|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|hormone metabolic process|regulation of signaling|cell-cell junction|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|extracellular space|intracellular|anatomical structure development|multicellular organismal reproductive process|positive regulation of cell proliferation|cellular carbohydrate metabolic process|regulation of cell proliferation|cellular aromatic compound metabolic process|kidney development|tube development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|response to water deprivation|small molecule metabolic process|vesicle|cellular response to stress|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|carbohydrate metabolic process|homeostatic process|regulation of signal transduction|oxidoreductase activity, acting on the aldehyde or oxo group of donors|polyketide metabolic process|cofactor metabolic process|maternal process involved in female pregnancy|response to oxidative stress|multicellular organismal homeostasis|regulation of cell communication|cell projection cytoplasm|cell communication|female pregnancy|lipid metabolic process|signal transduction|C21-steroid hormone metabolic process|extracellular exosome|cellular ketone metabolic process|hormone biosynthetic process|response to hormone|glial cell projection|paranodal junction|regulation of hormone levels|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|collecting duct development|oxidation-reduction process|positive regulation of intracellular signal transduction|cytosol|glyceraldehyde oxidoreductase activity|regulation of smooth muscle cell proliferation|response to hydrogen peroxide|urogenital system development|daunorubicin metabolic process|tissue homeostasis|alcohol metabolic process|response to thyroid hormone|response to peptide|smooth muscle cell proliferation|vacuole|cellular response to organonitrogen compound|inner medullary collecting duct development|positive regulation of smooth muscle cell proliferation|renal system development|C21-steroid hormone biosynthetic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|nuclear lumen|stress-activated protein kinase signaling cascade|cellular response to oxidative stress|doxorubicin metabolic process|monosaccharide metabolic process|perinuclear region of cytoplasm|Schwann cell microvillus|nucleoplasm|phenol-containing compound metabolic process|steroid metabolic process|response to reactive oxygen species|intracellular signal transduction|lipid biosynthetic process|quinone metabolic process|cellular response to organic substance|microvillus|regulation of intracellular signal transduction|catecholamine metabolic process|nucleus|carbohydrate biosynthetic process|glycoside metabolic process|sorbitol metabolic process|hexose metabolic process|cellular response to peptide|lytic vacuole|naphthalene metabolic process|steroid biosynthetic process|norepinephrine metabolic process|cellular response to methylglyoxal|aldo-keto reductase (NADP) activity|response to methylglyoxal|cellular response to reactive oxygen species|cellular response to hydrogen peroxide|catechol-containing compound metabolic process|alcohol dehydrogenase (NADP+) activity|JAK-STAT cascade|hexose biosynthetic process|lysosome|regulation of JAK-STAT cascade|fructose metabolic process|positive regulation of JAK-STAT cascade|sorbitol biosynthetic process|fructose biosynthetic process|mast cell granule|alditol:NADP+ 1-oxidoreductase activity K00011 aldehyde reductase[1.1.1.21] hsa01100|hsa00561|hsa00040|hsa00051|hsa00052 Metabolic pathways - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Fructose and mannose metabolism - Homo sapiens (human)|Galactose metabolism - Homo sapiens (human) 7:134442350-134459284 17355 18762 21420 49065 46248 53241 154.614366344191 151.909312807268 172.051683078768 391.646943568861 338.054049307563 444.529290608484 159.525120743409 391.410094494969 -1.29489733766957 6.18856386648032e-10 1.42227394665053e-08 DOWN ENSG00000070423 RNF126 ring finger protein 126 [Source:HGNC Symbol;Acc:HGNC:21151] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0042127|GO:0006810|GO:0005102|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0071629|GO:0009968|GO:0051649|GO:0019787|GO:0019538|GO:0010033|GO:0016192|GO:0046872|GO:0007166|GO:0070851|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:0046907|GO:1901184|GO:0006508|GO:1901185|GO:0044267|GO:0071310|GO:0035967|GO:0051788|GO:0005634|GO:0044257|GO:0061630|GO:0010498|GO:0005154|GO:0042058|GO:0042147|GO:0016482|GO:0051603|GO:0007167|GO:0071218|GO:0016197|GO:0042059|GO:0046914|GO:0006464|GO:0019941|GO:0008270|GO:0006515|GO:0043161|GO:0007169|GO:0032446|GO:0006511|GO:0038127|GO:0007173|GO:0042787|GO:0043162|GO:0016567|GO:0006513|GO:0000209|GO:0070534|GO:0070936 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|ligase activity|intracellular|protein binding|transferase activity|regulation of cell proliferation|transport|receptor binding|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process|negative regulation of signal transduction|establishment of localization in cell|ubiquitin-like protein transferase activity|protein metabolic process|response to organic substance|vesicle-mediated transport|metal ion binding|cell surface receptor signaling pathway|growth factor receptor binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|intracellular transport|regulation of ERBB signaling pathway|proteolysis|negative regulation of ERBB signaling pathway|cellular protein metabolic process|cellular response to organic substance|cellular response to topologically incorrect protein|response to misfolded protein|nucleus|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|epidermal growth factor receptor binding|regulation of epidermal growth factor receptor signaling pathway|retrograde transport, endosome to Golgi|cytosolic transport|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|cellular response to misfolded protein|endosomal transport|negative regulation of epidermal growth factor receptor signaling pathway|transition metal ion binding|cellular protein modification process|modification-dependent protein catabolic process|zinc ion binding|misfolded or incompletely synthesized protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|protein ubiquitination|protein monoubiquitination|protein polyubiquitination|protein K63-linked ubiquitination|protein K48-linked ubiquitination - - - - 19:647526-663277 1677 1890 1801 835 966 759 17.312568279817 17.7325136423509 16.7631788301722 7.72347470459366 8.18225937594561 7.34343655125864 17.26942025078 7.74972354393264 1.15600290004848 6.22586980009203e-10 1.42974705393806e-08 UP ENSG00000113389 NPR3 natriuretic peptide receptor 3 [Source:HGNC Symbol;Acc:HGNC:7945] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0033218|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0042562|GO:0006807|GO:0071704|GO:0044237|GO:0038023|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0042802|GO:0042127|GO:0003014|GO:0042277|GO:0017046|GO:0006725|GO:0070661|GO:0006810|GO:1901360|GO:0007275|GO:0033687|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0005887|GO:0004888|GO:0046983|GO:0006139|GO:0031226|GO:0043085|GO:0055086|GO:0007154|GO:0007165|GO:0070062|GO:0007586|GO:0008285|GO:0008217|GO:0050790|GO:0016021|GO:0044249|GO:0050878|GO:0003013|GO:0007186|GO:0030157|GO:0048660|GO:0033688|GO:0007589|GO:0048659|GO:0002158|GO:0051353|GO:0051341|GO:0006796|GO:0035556|GO:0046903|GO:0001501|GO:0016941|GO:0008528|GO:0008015|GO:0004930|GO:0042803|GO:0048662|GO:0007200|GO:0007187|GO:0035810|GO:0009117|GO:0032770|GO:0048017|GO:0019932|GO:0009165|GO:0051000|GO:0048015|GO:0019935|GO:0007188|GO:0050999|GO:0009187|GO:0009190|GO:0007193|GO:0019933 developmental process|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|amide binding|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|hormone binding|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|signaling receptor activity|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cell proliferation|renal system process|peptide binding|peptide hormone binding|cellular aromatic compound metabolic process|leukocyte proliferation|transport|organic cyclic compound metabolic process|multicellular organism development|osteoblast proliferation|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|integral component of plasma membrane|transmembrane signaling receptor activity|protein dimerization activity|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|extracellular exosome|digestion|negative regulation of cell proliferation|regulation of blood pressure|regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|regulation of body fluid levels|circulatory system process|G-protein coupled receptor signaling pathway|pancreatic juice secretion|regulation of smooth muscle cell proliferation|regulation of osteoblast proliferation|body fluid secretion|smooth muscle cell proliferation|osteoclast proliferation|positive regulation of oxidoreductase activity|regulation of oxidoreductase activity|phosphate-containing compound metabolic process|intracellular signal transduction|secretion|skeletal system development|natriuretic peptide receptor activity|G-protein coupled peptide receptor activity|blood circulation|G-protein coupled receptor activity|protein homodimerization activity|negative regulation of smooth muscle cell proliferation|phospholipase C-activating G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|positive regulation of urine volume|nucleotide metabolic process|positive regulation of monooxygenase activity|inositol lipid-mediated signaling|second-messenger-mediated signaling|nucleotide biosynthetic process|positive regulation of nitric-oxide synthase activity|phosphatidylinositol-mediated signaling|cyclic-nucleotide-mediated signaling|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|regulation of nitric-oxide synthase activity|cyclic nucleotide metabolic process|cyclic nucleotide biosynthetic process|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|cAMP-mediated signaling - - - - 5:32689070-32791724 33 47 60 172 194 158 0.132105657538924 0.17099794127754 0.216560066295929 0.616928236508393 0.637203393211883 0.592783677868539 0.173221221704131 0.615638435862938 -1.82946761701198 6.24062656482275e-10 1.43203432333757e-08 DOWN ENSG00000073417 PDE8A phosphodiesterase 8A [Source:HGNC Symbol;Acc:HGNC:8793] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0050794|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0016788|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0043169|GO:0005737|GO:0006139|GO:0055086|GO:0007154|GO:0007165|GO:0070062|GO:0044249|GO:0031323|GO:0005829|GO:0010468|GO:0034645|GO:0046872|GO:0019693|GO:0051252|GO:0006796|GO:0035556|GO:0010467|GO:0019439|GO:0009059|GO:0016070|GO:0046434|GO:0042578|GO:0008081|GO:0009259|GO:0009117|GO:0032774|GO:2001141|GO:0000160|GO:0006163|GO:0009166|GO:0006351|GO:0006355|GO:0006195|GO:0004112|GO:0009154|GO:1903506|GO:0009187|GO:0009214|GO:0046058|GO:0004114|GO:0006198|GO:0004115 signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|cation binding|cytoplasm|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|extracellular exosome|cellular biosynthetic process|regulation of cellular metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|ribose phosphate metabolic process|regulation of RNA metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|gene expression|aromatic compound catabolic process|macromolecule biosynthetic process|RNA metabolic process|organophosphate catabolic process|phosphoric ester hydrolase activity|phosphoric diester hydrolase activity|ribonucleotide metabolic process|nucleotide metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorelay signal transduction system|purine nucleotide metabolic process|nucleotide catabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|purine nucleotide catabolic process|cyclic-nucleotide phosphodiesterase activity|purine ribonucleotide catabolic process|regulation of nucleic acid-templated transcription|cyclic nucleotide metabolic process|cyclic nucleotide catabolic process|cAMP metabolic process|3',5'-cyclic-nucleotide phosphodiesterase activity|cAMP catabolic process|3',5'-cyclic-AMP phosphodiesterase activity K18437 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8[3.1.4.53] hsa00230|hsa05032 Purine metabolism - Homo sapiens (human)|Morphine addiction - Homo sapiens (human) 15:84980440-85139145 293 390 458 939 1026 1004 1.52172501670862 1.84083029810226 2.14461186362729 4.36950079839489 4.37203978453136 4.88687810958346 1.83572239281272 4.54280623083657 -1.30723586626019 6.30417206617184e-10 1.44550501431255e-08 DOWN ENSG00000188522 FAM83G family with sequence similarity 83 member G [Source:HGNC Symbol;Acc:HGNC:32554] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0010033|GO:0031323|GO:0005829|GO:0010468|GO:0071773|GO:0034645|GO:0007166|GO:0051252|GO:0070848|GO:0010467|GO:0071310|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0071363|GO:0030509|GO:0007167|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0007178 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|cytosol|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|regulation of RNA metabolic process|response to growth factor|gene expression|cellular response to organic substance|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|BMP signaling pathway|enzyme linked receptor protein signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway - - - - 17:18968789-19004804 2362 2477 2208 1074 1204 1049 15.7089533861026 14.9717807655566 13.2397769508544 6.39984274577913 6.56994744560587 6.53840644775067 14.6401703675045 6.50273221304522 1.17081442339953 6.33101081609556e-10 1.45054487263021e-08 UP ENSG00000116731 PRDM2 PR domain containing 2, with ZNF domain [Source:HGNC Symbol;Acc:HGNC:9347] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0008340|GO:0009725|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0007568|GO:0051276|GO:0003677|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0043412|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0010259|GO:0014070|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0048545|GO:0097305|GO:0032774|GO:2001141|GO:0043627|GO:0018022|GO:0008276|GO:0034968|GO:0032355|GO:0046914|GO:0016568|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0016279|GO:1903506|GO:0018193|GO:0042054|GO:0008270|GO:0018024|GO:0018205 developmental process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|catalytic activity|methylation|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|determination of adult lifespan|response to hormone|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|aging|chromosome organization|DNA binding|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|macromolecule modification|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|protein modification process|multicellular organism aging|response to organic cyclic compound|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|response to steroid hormone|response to alcohol|RNA biosynthetic process|regulation of RNA biosynthetic process|response to estrogen|peptidyl-lysine methylation|protein methyltransferase activity|histone lysine methylation|response to estradiol|transition metal ion binding|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|protein-lysine N-methyltransferase activity|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone methyltransferase activity|zinc ion binding|histone-lysine N-methyltransferase activity|peptidyl-lysine modification - - - - 1:13700198-13825079 175 202 225 570 538 607 0.688713515855932 0.722489986645824 0.798358439040558 2.00989583508773 1.7372055350745 2.23881855181394 0.736520647180771 1.99530664065872 -1.437812603665 6.34899801475961e-10 1.45355051175332e-08 DOWN ENSG00000135250 SRPK2 SRSF protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:11306] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0016032|GO:0048514|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0045087|GO:0006725|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0003676|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0048524|GO:0046483|GO:0022607|GO:0010942|GO:0043231|GO:0043169|GO:0005737|GO:0071889|GO:0045787|GO:0006139|GO:0001525|GO:0007154|GO:0007165|GO:0048525|GO:0008219|GO:0000166|GO:0048869|GO:0022613|GO:0019538|GO:0050792|GO:0031323|GO:0006996|GO:0005730|GO:0010468|GO:0046872|GO:0003723|GO:0035639|GO:0001944|GO:0043412|GO:0072358|GO:0051252|GO:0001883|GO:1901216|GO:0070997|GO:0010628|GO:0036211|GO:0032549|GO:0022618|GO:0031981|GO:0005654|GO:0016301|GO:1901214|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:1903902|GO:0010467|GO:0019079|GO:0019058|GO:0017076|GO:0006997|GO:0030154|GO:0043068|GO:0016070|GO:0072359|GO:0016773|GO:0005634|GO:0043067|GO:0034622|GO:0043065|GO:0006396|GO:0043523|GO:0050684|GO:0000287|GO:0005524|GO:0043525|GO:0043484|GO:0030554|GO:0016310|GO:0045069|GO:0045070|GO:0045071|GO:0016071|GO:0042981|GO:0004672|GO:0044822|GO:0051402|GO:0006464|GO:0006915|GO:0000245|GO:0006468|GO:0048024|GO:0006397|GO:0035063|GO:0004674|GO:0008380|GO:0000375|GO:0000398 developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|viral process|blood vessel morphogenesis|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of viral process|heterocycle metabolic process|cellular component assembly|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|cytoplasm|14-3-3 protein binding|positive regulation of cell cycle|nucleobase-containing compound metabolic process|angiogenesis|cell communication|signal transduction|negative regulation of viral process|cell death|nucleotide binding|cellular developmental process|ribonucleoprotein complex biogenesis|protein metabolic process|regulation of viral process|regulation of cellular metabolic process|organelle organization|nucleolus|regulation of gene expression|metal ion binding|RNA binding|purine ribonucleoside triphosphate binding|vasculature development|macromolecule modification|cardiovascular system development|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of neuron death|neuron death|positive regulation of gene expression|protein modification process|ribonucleoside binding|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|kinase activity|regulation of neuron death|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|positive regulation of viral life cycle|gene expression|viral genome replication|viral life cycle|purine nucleotide binding|nucleus organization|cell differentiation|positive regulation of programmed cell death|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|nucleus|regulation of programmed cell death|cellular macromolecular complex assembly|positive regulation of apoptotic process|RNA processing|regulation of neuron apoptotic process|regulation of mRNA processing|magnesium ion binding|ATP binding|positive regulation of neuron apoptotic process|regulation of RNA splicing|adenyl nucleotide binding|phosphorylation|regulation of viral genome replication|positive regulation of viral genome replication|negative regulation of viral genome replication|mRNA metabolic process|regulation of apoptotic process|protein kinase activity|poly(A) RNA binding|neuron apoptotic process|cellular protein modification process|apoptotic process|spliceosomal complex assembly|protein phosphorylation|regulation of mRNA splicing, via spliceosome|mRNA processing|nuclear speck organization|protein serine/threonine kinase activity|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 7:105110704-105399308 242 277 508 998 1081 1007 1.32004298001563 1.37319656851944 2.49833302635193 4.87754279770385 4.83800620528085 5.1479131006061 1.730524191629 4.9544873678636 -1.5175266823983 6.43171109744544e-10 1.47135864446848e-08 DOWN ENSG00000104140 RHOV ras homolog family member V [Source:HGNC Symbol;Acc:HGNC:18313] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0023051|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0043168|GO:0001882|GO:0043231|GO:0043169|GO:0005737|GO:0009966|GO:0045184|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0010008|GO:0000166|GO:0005768|GO:0005829|GO:0046872|GO:0035639|GO:0001883|GO:0015031|GO:0032549|GO:0035556|GO:0017076|GO:1902531|GO:0032561|GO:0005525|GO:0051056|GO:0007264|GO:0019001 signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|regulation of signaling|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|transport|anion binding|nucleoside binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|regulation of signal transduction|establishment of protein localization|regulation of cell communication|protein localization|cell communication|signal transduction|endosome membrane|nucleotide binding|endosome|cytosol|metal ion binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|regulation of intracellular signal transduction|guanyl ribonucleotide binding|GTP binding|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|guanyl nucleotide binding - - - - 15:40872214-40874289 626 587 868 222 217 339 25.9714161260804 22.1329482375787 32.4679652019737 8.25225832916891 7.38666098475352 13.1810488874267 26.8574431885443 9.60665606711638 1.48321572466719 6.46436281070148e-10 1.4776959215213e-08 UP ENSG00000066933 MYO9A myosin IXA [Source:HGNC Symbol;Acc:HGNC:7608] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0023051|GO:0009893|GO:0016787|GO:0031224|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0050877|GO:0043168|GO:0008047|GO:0001882|GO:0016817|GO:0043169|GO:0005737|GO:0009966|GO:0016459|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008092|GO:0050790|GO:0000166|GO:0016021|GO:0005829|GO:0005096|GO:0016461|GO:0046872|GO:0035639|GO:0051345|GO:0030695|GO:0001883|GO:0003779|GO:0016818|GO:0032549|GO:0007600|GO:0035556|GO:0017076|GO:1902531|GO:0005856|GO:0015629|GO:0050953|GO:0005524|GO:0043087|GO:0030554|GO:0043547|GO:0051056|GO:0007264|GO:0016462|GO:0017111|GO:0007601|GO:0003774 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|regulation of signaling|positive regulation of metabolic process|hydrolase activity|intrinsic component of membrane|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|neurological system process|anion binding|enzyme activator activity|nucleoside binding|hydrolase activity, acting on acid anhydrides|cation binding|cytoplasm|regulation of signal transduction|myosin complex|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cytoskeletal protein binding|regulation of catalytic activity|nucleotide binding|integral component of membrane|cytosol|GTPase activator activity|unconventional myosin complex|metal ion binding|purine ribonucleoside triphosphate binding|positive regulation of hydrolase activity|GTPase regulator activity|purine nucleoside binding|actin binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|sensory perception|intracellular signal transduction|purine nucleotide binding|regulation of intracellular signal transduction|cytoskeleton|actin cytoskeleton|sensory perception of light stimulus|ATP binding|regulation of GTPase activity|adenyl nucleotide binding|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|pyrophosphatase activity|nucleoside-triphosphatase activity|visual perception|motor activity - - - - 15:71822289-72118577 87 97 137 327 332 463 0.179755758580453 0.182144489026978 0.255209706283201 0.605353007395971 0.562819260576807 0.896546866782205 0.205703317963544 0.688239711584994 -1.7423460737982 6.47762959254193e-10 1.47959566836838e-08 DOWN ENSG00000147251 DOCK11 dedicator of cytokinesis 11 [Source:HGNC Symbol;Acc:HGNC:23483] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0019222|GO:0050817|GO:0019899|GO:0005737|GO:0009611|GO:0005088|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0050878|GO:0005829|GO:0051345|GO:0007596|GO:0042060|GO:0007599|GO:0035556|GO:0051020|GO:0005089|GO:0043087|GO:0043547|GO:0031267|GO:0007264|GO:0017016|GO:0017048 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|coagulation|enzyme binding|cytoplasm|response to wounding|Ras guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|regulation of body fluid levels|cytosol|positive regulation of hydrolase activity|blood coagulation|wound healing|hemostasis|intracellular signal transduction|GTPase binding|Rho guanyl-nucleotide exchange factor activity|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase binding|small GTPase mediated signal transduction|Ras GTPase binding|Rho GTPase binding - - - - X:118495898-118686163 55 76 129 306 318 486 0.482813553551914 0.606333452222547 1.0209897106401 2.40678824963651 2.29041247791266 3.99837325742664 0.70337890547152 2.8985246616586 -2.04294478671697 6.53525030004668e-10 1.49161592092962e-08 DOWN ENSG00000055208 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [Source:HGNC Symbol;Acc:HGNC:17075] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0007507|GO:0002757|GO:0032182|GO:0045087|GO:0006725|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0002218|GO:0009966|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0010008|GO:0050790|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0005768|GO:0051090|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0046872|GO:0007166|GO:0043412|GO:0002758|GO:0072358|GO:0034097|GO:0043130|GO:0051252|GO:0010628|GO:0051347|GO:0036211|GO:0051091|GO:0002429|GO:0031098|GO:0051247|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:1902531|GO:0016070|GO:0072359|GO:0010557|GO:0045089|GO:0030522|GO:0045088|GO:0045893|GO:0019221|GO:0031401|GO:0043122|GO:0043408|GO:0032774|GO:2001141|GO:0016310|GO:0051092|GO:0002768|GO:0035872|GO:0002221|GO:0043123|GO:0007249|GO:0043410|GO:0071345|GO:0046914|GO:0034612|GO:0031593|GO:0006464|GO:0050851|GO:0051403|GO:0043549|GO:0006351|GO:0006355|GO:0033674|GO:0002223|GO:0045859|GO:0045860|GO:0002224|GO:0043406|GO:0006468|GO:0071356|GO:1903506|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0070423|GO:0038093|GO:0070530|GO:0033209|GO:0001934|GO:0050852|GO:0008270|GO:0042327|GO:0034166|GO:0034134|GO:0038124|GO:0000187|GO:0038095|GO:0002756|GO:0071902|GO:0034138|GO:0002755|GO:0034146|GO:0071900|GO:0034142|GO:0038123|GO:0034162|GO:0032147|GO:0035666 developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|heart development|immune response-activating signal transduction|ubiquitin-like protein binding|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|activation of innate immune response|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|endosome membrane|regulation of catalytic activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|endosome|regulation of sequence-specific DNA binding transcription factor activity|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|innate immune response-activating signal transduction|cardiovascular system development|response to cytokine|ubiquitin binding|regulation of RNA metabolic process|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|positive regulation of sequence-specific DNA binding transcription factor activity|immune response-activating cell surface receptor signaling pathway|stress-activated protein kinase signaling cascade|positive regulation of protein metabolic process|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|positive regulation of innate immune response|intracellular receptor signaling pathway|regulation of innate immune response|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of MAPK cascade|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorylation|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|pattern recognition receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|cellular response to cytokine stimulus|transition metal ion binding|response to tumor necrosis factor|polyubiquitin binding|cellular protein modification process|antigen receptor-mediated signaling pathway|stress-activated MAPK cascade|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of kinase activity|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|protein phosphorylation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|nucleotide-binding oligomerization domain containing signaling pathway|Fc receptor signaling pathway|K63-linked polyubiquitin binding|tumor necrosis factor-mediated signaling pathway|positive regulation of protein phosphorylation|T cell receptor signaling pathway|zinc ion binding|positive regulation of phosphorylation|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|activation of MAPK activity|Fc-epsilon receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|regulation of protein serine/threonine kinase activity|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|activation of protein kinase activity|TRIF-dependent toll-like receptor signaling pathway K04404 TAK1-binding protein 2[-] hsa04010|hsa05169|hsa05168|hsa05162|hsa04380|hsa05145|hsa04668|hsa04620|hsa04064|hsa05140|hsa04621 MAPK signaling pathway - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Measles - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|NOD-like receptor signaling pathway - Homo sapiens (human) 6:149218641-149411613 500 568 873 1640 1801 1900 3.34928390130729 3.45788337407455 5.27242464995507 9.84290452401008 9.89836293478197 11.9279083304692 4.02653064177897 10.5563919297538 -1.39050760264839 6.55448755704749e-10 1.49486380082579e-08 DOWN ENSG00000176225 RTTN rotatin [Source:HGNC Symbol;Acc:HGNC:18654] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0043229|GO:0016043|GO:0005622|GO:0048856|GO:0005929|GO:0007275|GO:0005737|GO:0007389|GO:0036064|GO:0030030|GO:0006996|GO:0005813|GO:0005815|GO:0044782|GO:0005856|GO:0015630|GO:0009855|GO:0007368 developmental process|cell|cellular process|binding|cell projection|intracellular organelle|cellular component organization|intracellular|anatomical structure development|cilium|multicellular organism development|cytoplasm|pattern specification process|ciliary basal body|cell projection organization|organelle organization|centrosome|microtubule organizing center|cilium organization|cytoskeleton|microtubule cytoskeleton|determination of bilateral symmetry|determination of left/right symmetry - - - - 18:70003793-70205945 105 143 207 438 542 477 0.619516935922618 0.766795781296589 1.1011501916235 2.31544346222478 2.62379422429466 2.63760526175611 0.829154302947569 2.52561431609185 -1.60692183077895 6.68697656053733e-10 1.52391601708612e-08 DOWN ENSG00000168811 IL12A interleukin 12A [Source:HGNC Symbol;Acc:HGNC:5969] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0001909|GO:0040012|GO:0006950|GO:0048520|GO:0071704|GO:0050900|GO:0006955|GO:0009628|GO:0044237|GO:0050795|GO:0048870|GO:0023051|GO:0040017|GO:0051707|GO:0043514|GO:0007155|GO:0009607|GO:0009605|GO:0009893|GO:0005615|GO:0002684|GO:0042267|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0001913|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0036336|GO:0008284|GO:0001818|GO:0051272|GO:0051726|GO:0042127|GO:0002250|GO:0007049|GO:1903706|GO:0016337|GO:0001914|GO:0006935|GO:0045087|GO:0045595|GO:0070661|GO:0002685|GO:0009314|GO:0050867|GO:0022402|GO:0010941|GO:0001562|GO:0007275|GO:0048513|GO:0070489|GO:0005102|GO:0006952|GO:0030155|GO:0031325|GO:2000147|GO:0010942|GO:0098542|GO:0001817|GO:0098609|GO:0045786|GO:0045597|GO:0005737|GO:0001816|GO:0001910|GO:0001912|GO:0050920|GO:0042269|GO:0006928|GO:0009615|GO:0002687|GO:0002696|GO:0001775|GO:0009966|GO:0046983|GO:0001819|GO:0010646|GO:0009617|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0045785|GO:0019955|GO:0001916|GO:0008219|GO:0008285|GO:0030595|GO:0048869|GO:2000145|GO:0002347|GO:0009967|GO:0045954|GO:0019538|GO:0010033|GO:0031323|GO:0002418|GO:0050921|GO:0002443|GO:1902533|GO:0051249|GO:0032268|GO:0005126|GO:0048660|GO:0030101|GO:0032943|GO:0002688|GO:0007166|GO:0070851|GO:0033993|GO:0043412|GO:0030097|GO:0030098|GO:0002237|GO:0002690|GO:0046982|GO:0034109|GO:0005125|GO:0002228|GO:0048659|GO:0007050|GO:0030334|GO:0036211|GO:0071219|GO:0051251|GO:0022407|GO:0098586|GO:0032700|GO:0060326|GO:0007159|GO:0051247|GO:0002821|GO:0002460|GO:0032270|GO:0042110|GO:0012501|GO:0002407|GO:0006796|GO:0035556|GO:0044267|GO:0032609|GO:0051174|GO:0071310|GO:0002819|GO:0002860|GO:0051246|GO:0042742|GO:0042832|GO:0046651|GO:0030154|GO:0022409|GO:0030335|GO:0043068|GO:0002839|GO:0032729|GO:1902531|GO:0008083|GO:0032620|GO:0032496|GO:0009416|GO:0043067|GO:0048662|GO:0045089|GO:0097190|GO:0045088|GO:0032649|GO:0002521|GO:0042098|GO:0002456|GO:2000510|GO:0031401|GO:0050863|GO:2000508|GO:0032816|GO:0043065|GO:0009411|GO:0042163|GO:0030217|GO:0016310|GO:0045619|GO:0045513|GO:0034112|GO:0070486|GO:0046631|GO:0050830|GO:0002715|GO:0042981|GO:0002717|GO:0006464|GO:0050870|GO:0071396|GO:0097191|GO:0045621|GO:0050671|GO:0005143|GO:0006915|GO:0071222|GO:1903039|GO:0032946|GO:0045582|GO:0010224|GO:0007259|GO:0002711|GO:0006468|GO:0045580|GO:0046425|GO:0042325|GO:0001932|GO:0018193|GO:0046427|GO:0001934|GO:0010657|GO:0042129|GO:0071593|GO:0042327|GO:0042102|GO:0050731|GO:0034393|GO:0050730|GO:0051135|GO:0007260|GO:0042531|GO:0034391|GO:0018108|GO:0042520 locomotion|developmental process|macromolecular complex|immune system process|behavior|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|leukocyte mediated cytotoxicity|regulation of locomotion|response to stress|positive regulation of behavior|organic substance metabolic process|leukocyte migration|immune response|response to abiotic stimulus|cellular metabolic process|regulation of behavior|cell motility|regulation of signaling|positive regulation of locomotion|response to other organism|interleukin-12 complex|cell adhesion|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|extracellular space|positive regulation of immune system process|natural killer cell mediated cytotoxicity|regulation of developmental process|intracellular|regulation of immune system process|immune system development|T cell mediated cytotoxicity|protein binding|protein complex|anatomical structure development|regulation of metabolic process|dendritic cell migration|positive regulation of cell proliferation|negative regulation of cytokine production|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|adaptive immune response|cell cycle|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of T cell mediated cytotoxicity|chemotaxis|innate immune response|regulation of cell differentiation|leukocyte proliferation|regulation of leukocyte migration|response to radiation|positive regulation of cell activation|cell cycle process|regulation of cell death|response to protozoan|multicellular organism development|animal organ development|T cell aggregation|receptor binding|defense response|regulation of cell adhesion|positive regulation of cellular metabolic process|positive regulation of cell motility|positive regulation of cell death|defense response to other organism|regulation of cytokine production|cell-cell adhesion|negative regulation of cell cycle|positive regulation of cell differentiation|cytoplasm|cytokine production|regulation of leukocyte mediated cytotoxicity|positive regulation of leukocyte mediated cytotoxicity|regulation of chemotaxis|regulation of natural killer cell mediated cytotoxicity|movement of cell or subcellular component|response to virus|positive regulation of leukocyte migration|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|protein dimerization activity|positive regulation of cytokine production|regulation of cell communication|response to bacterium|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|positive regulation of cell adhesion|cytokine binding|positive regulation of T cell mediated cytotoxicity|cell death|negative regulation of cell proliferation|leukocyte chemotaxis|cellular developmental process|regulation of cell motility|response to tumor cell|positive regulation of signal transduction|positive regulation of natural killer cell mediated cytotoxicity|protein metabolic process|response to organic substance|regulation of cellular metabolic process|immune response to tumor cell|positive regulation of chemotaxis|leukocyte mediated immunity|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytokine receptor binding|regulation of smooth muscle cell proliferation|natural killer cell activation|mononuclear cell proliferation|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|growth factor receptor binding|response to lipid|macromolecule modification|hemopoiesis|lymphocyte differentiation|response to molecule of bacterial origin|positive regulation of leukocyte chemotaxis|protein heterodimerization activity|homotypic cell-cell adhesion|cytokine activity|natural killer cell mediated immunity|smooth muscle cell proliferation|cell cycle arrest|regulation of cell migration|protein modification process|cellular response to molecule of bacterial origin|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|cellular response to virus|negative regulation of interleukin-17 production|cell chemotaxis|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|positive regulation of adaptive immune response|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|dendritic cell chemotaxis|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|interferon-gamma production|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of adaptive immune response|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|regulation of protein metabolic process|defense response to bacterium|defense response to protozoan|lymphocyte proliferation|cell differentiation|positive regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of programmed cell death|positive regulation of immune response to tumor cell|positive regulation of interferon-gamma production|regulation of intracellular signal transduction|growth factor activity|interleukin-17 production|response to lipopolysaccharide|response to light stimulus|regulation of programmed cell death|negative regulation of smooth muscle cell proliferation|positive regulation of innate immune response|apoptotic signaling pathway|regulation of innate immune response|regulation of interferon-gamma production|leukocyte differentiation|T cell proliferation|T cell mediated immunity|positive regulation of dendritic cell chemotaxis|positive regulation of protein modification process|regulation of T cell activation|regulation of dendritic cell chemotaxis|positive regulation of natural killer cell activation|positive regulation of apoptotic process|response to UV|interleukin-12 beta subunit binding|T cell differentiation|phosphorylation|regulation of lymphocyte differentiation|interleukin-27 binding|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|alpha-beta T cell activation|defense response to Gram-positive bacterium|regulation of natural killer cell mediated immunity|regulation of apoptotic process|positive regulation of natural killer cell mediated immunity|cellular protein modification process|positive regulation of T cell activation|cellular response to lipid|extrinsic apoptotic signaling pathway|positive regulation of lymphocyte differentiation|positive regulation of lymphocyte proliferation|interleukin-12 receptor binding|apoptotic process|cellular response to lipopolysaccharide|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|positive regulation of T cell differentiation|response to UV-B|JAK-STAT cascade|positive regulation of T cell mediated immunity|protein phosphorylation|regulation of T cell differentiation|regulation of JAK-STAT cascade|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of JAK-STAT cascade|positive regulation of protein phosphorylation|muscle cell apoptotic process|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of phosphorylation|positive regulation of T cell proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of smooth muscle cell apoptotic process|regulation of peptidyl-tyrosine phosphorylation|positive regulation of NK T cell activation|tyrosine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|regulation of smooth muscle cell apoptotic process|peptidyl-tyrosine phosphorylation|positive regulation of tyrosine phosphorylation of Stat4 protein K05406 interleukin 12A[-] hsa04060|hsa05168|hsa05152|hsa05164|hsa04630|hsa05162|hsa05145|hsa04620|hsa05142|hsa05146|hsa05133|hsa05140|hsa04622|hsa05321|hsa05134|hsa05144|hsa04940|hsa05330|hsa05143 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Measles - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|RIG-I-like receptor signaling pathway - Homo sapiens (human)|Inflammatory bowel disease (IBD) - Homo sapiens (human)|Legionellosis - Homo sapiens (human)|Malaria - Homo sapiens (human)|Type I diabetes mellitus - Homo sapiens (human)|Allograft rejection - Homo sapiens (human)|African trypanosomiasis - Homo sapiens (human) 3:159988750-159996019 63 65 127 16 12 23 0.939583887635577 0.881025734724307 1.70769112046058 0.213794965949254 0.146841265921898 0.321480854720371 1.17610024760682 0.227372362197174 2.37088223081635 6.80703419311889e-10 1.55009304959093e-08 UP ENSG00000006704 GTF2IRD1 GTF2I repeat domain containing 1 [Source:HGNC Symbol;Acc:HGNC:4661] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0003012|GO:0006139|GO:0044249|GO:0031323|GO:0014733|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0090257|GO:0003705|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0014886|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|muscle system process|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of skeletal muscle adaptation|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|regulation of muscle system process|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|transition between slow and fast fiber|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription K03121 transcription initiation factor TFII-I[-] hsa05168|hsa04022|hsa03022 Herpes simplex infection - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Basal transcription factors - Homo sapiens (human) 7:74453790-74602604 95 101 221 496 537 515 0.808759977656243 0.781447579088204 1.69630309006236 3.78334491315263 3.75092899986096 4.10897344942825 1.0955035489356 3.88108245414728 -1.82486492569516 6.8404077775227e-10 1.55650559291283e-08 DOWN ENSG00000089163 SIRT4 sirtuin 4 [Source:HGNC Symbol;Acc:HGNC:14932] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0048037|GO:1903828|GO:0023057|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0031090|GO:0019222|GO:0060341|GO:0006486|GO:0044255|GO:0006725|GO:0019866|GO:0006810|GO:1901360|GO:0010941|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0032940|GO:0046483|GO:0051128|GO:0033554|GO:0043231|GO:0043169|GO:1903748|GO:0005737|GO:0006520|GO:0007267|GO:0032880|GO:0016810|GO:0005975|GO:0031966|GO:0045184|GO:0009890|GO:0046883|GO:0060548|GO:0032387|GO:0016458|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0006629|GO:0016757|GO:0042180|GO:0051649|GO:0046888|GO:0008219|GO:0050662|GO:0001666|GO:0090317|GO:0050790|GO:0051048|GO:1903531|GO:0000166|GO:0045833|GO:0010817|GO:0044249|GO:0019538|GO:0051224|GO:0031324|GO:0031323|GO:0006996|GO:0055114|GO:0051276|GO:0032268|GO:0005740|GO:0010468|GO:0034645|GO:0046872|GO:0090276|GO:0043412|GO:0072594|GO:0010629|GO:0007005|GO:0043069|GO:0051252|GO:0009308|GO:0006631|GO:0006325|GO:0032386|GO:0050709|GO:0051223|GO:0051604|GO:0016811|GO:0015031|GO:0046889|GO:0009100|GO:0036211|GO:0032269|GO:0071456|GO:0070201|GO:0034440|GO:0046907|GO:0042886|GO:0006521|GO:1903215|GO:0051046|GO:0005743|GO:0070403|GO:0009914|GO:0009306|GO:0006508|GO:0070085|GO:0005759|GO:0005739|GO:0071453|GO:0034613|GO:0010565|GO:0006342|GO:0051341|GO:0006471|GO:0012501|GO:1901137|GO:0002792|GO:0033043|GO:0044267|GO:0010467|GO:0008610|GO:0019216|GO:0046903|GO:0016763|GO:0046890|GO:0006626|GO:0045922|GO:0051246|GO:0009059|GO:1903827|GO:0030258|GO:0016070|GO:0051287|GO:0043067|GO:0006974|GO:0050796|GO:0019217|GO:0002790|GO:0006627|GO:0045814|GO:0009101|GO:1904182|GO:0030073|GO:0043413|GO:0033365|GO:0033157|GO:0046676|GO:0016485|GO:0045892|GO:0032774|GO:0006839|GO:0030162|GO:2001141|GO:0050708|GO:0015833|GO:0006605|GO:0072655|GO:1902679|GO:0010823|GO:0016482|GO:0006886|GO:0040029|GO:0010821|GO:1903217|GO:0042981|GO:0000820|GO:0045861|GO:0043066|GO:0019752|GO:0006464|GO:0061690|GO:0046322|GO:1903214|GO:0019395|GO:0046879|GO:0003950|GO:0006351|GO:0047708|GO:0006915|GO:0006355|GO:0034982|GO:0036294|GO:0072350|GO:1903533|GO:0030072|GO:0006541|GO:1903507|GO:0046320|GO:0010955|GO:1903506|GO:0070613|GO:0018193|GO:0032787|GO:0010657|GO:0010656|GO:0070585|GO:0010664|GO:0006476|GO:0018205|GO:0034983|GO:0010659|GO:0010667 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|cofactor binding|negative regulation of cellular protein localization|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|transferase activity|organelle membrane|regulation of metabolic process|regulation of cellular localization|protein glycosylation|cellular lipid metabolic process|cellular aromatic compound metabolic process|organelle inner membrane|transport|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|secretion by cell|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|cation binding|negative regulation of establishment of protein localization to mitochondrion|cytoplasm|cellular amino acid metabolic process|cell-cell signaling|regulation of protein localization|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|carbohydrate metabolic process|mitochondrial membrane|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|negative regulation of cell death|negative regulation of intracellular transport|gene silencing|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|lipid metabolic process|transferase activity, transferring glycosyl groups|cellular ketone metabolic process|establishment of localization in cell|negative regulation of hormone secretion|cell death|coenzyme binding|response to hypoxia|negative regulation of intracellular protein transport|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|nucleotide binding|negative regulation of lipid metabolic process|regulation of hormone levels|cellular biosynthetic process|protein metabolic process|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|chromosome organization|regulation of cellular protein metabolic process|mitochondrial envelope|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of peptide hormone secretion|macromolecule modification|establishment of protein localization to organelle|negative regulation of gene expression|mitochondrion organization|negative regulation of programmed cell death|regulation of RNA metabolic process|amine metabolic process|fatty acid metabolic process|chromatin organization|regulation of intracellular transport|negative regulation of protein secretion|regulation of protein transport|protein maturation|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|protein transport|positive regulation of lipid biosynthetic process|glycoprotein metabolic process|protein modification process|negative regulation of cellular protein metabolic process|cellular response to hypoxia|regulation of establishment of protein localization|lipid oxidation|intracellular transport|amide transport|regulation of cellular amino acid metabolic process|negative regulation of protein targeting to mitochondrion|regulation of secretion|mitochondrial inner membrane|NAD+ binding|hormone transport|protein secretion|proteolysis|glycosylation|mitochondrial matrix|mitochondrion|cellular response to oxygen levels|cellular protein localization|regulation of cellular ketone metabolic process|chromatin silencing|regulation of oxidoreductase activity|protein ADP-ribosylation|programmed cell death|carbohydrate derivative biosynthetic process|negative regulation of peptide secretion|regulation of organelle organization|cellular protein metabolic process|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|secretion|transferase activity, transferring pentosyl groups|regulation of lipid biosynthetic process|protein targeting to mitochondrion|negative regulation of fatty acid metabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of cellular protein localization|lipid modification|RNA metabolic process|NAD binding|regulation of programmed cell death|cellular response to DNA damage stimulus|regulation of insulin secretion|regulation of fatty acid metabolic process|peptide secretion|protein processing involved in protein targeting to mitochondrion|negative regulation of gene expression, epigenetic|glycoprotein biosynthetic process|regulation of pyruvate dehydrogenase activity|insulin secretion|macromolecule glycosylation|protein localization to organelle|regulation of intracellular protein transport|negative regulation of insulin secretion|protein processing|negative regulation of transcription, DNA-templated|RNA biosynthetic process|mitochondrial transport|regulation of proteolysis|regulation of RNA biosynthetic process|regulation of protein secretion|peptide transport|protein targeting|establishment of protein localization to mitochondrion|negative regulation of RNA biosynthetic process|negative regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|regulation of gene expression, epigenetic|regulation of mitochondrion organization|negative regulation of protein processing involved in protein targeting to mitochondrion|regulation of apoptotic process|regulation of glutamine family amino acid metabolic process|negative regulation of proteolysis|negative regulation of apoptotic process|carboxylic acid metabolic process|cellular protein modification process|lipoamidase activity|negative regulation of fatty acid oxidation|regulation of protein targeting to mitochondrion|fatty acid oxidation|hormone secretion|NAD+ ADP-ribosyltransferase activity|transcription, DNA-templated|biotinidase activity|apoptotic process|regulation of transcription, DNA-templated|mitochondrial protein processing|cellular response to decreased oxygen levels|tricarboxylic acid metabolic process|regulation of protein targeting|peptide hormone secretion|glutamine metabolic process|negative regulation of nucleic acid-templated transcription|regulation of fatty acid oxidation|negative regulation of protein processing|regulation of nucleic acid-templated transcription|regulation of protein processing|peptidyl-amino acid modification|monocarboxylic acid metabolic process|muscle cell apoptotic process|negative regulation of muscle cell apoptotic process|protein localization to mitochondrion|negative regulation of striated muscle cell apoptotic process|protein deacetylation|peptidyl-lysine modification|peptidyl-lysine deacetylation|cardiac muscle cell apoptotic process|negative regulation of cardiac muscle cell apoptotic process - - - - 12:120302316-120313249 68 61 68 13 11 21 1.96169700788006 1.59932946634629 1.76866804203468 0.336019178133291 0.260360887717459 0.567757620894324 1.77656483875368 0.388045895581691 2.19479114289761 6.89159544926388e-10 1.56695880077931e-08 UP ENSG00000100139 MICALL1 MICAL like 1 [Source:HGNC Symbol;Acc:HGNC:29804] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0042802|GO:0048468|GO:0006810|GO:0007275|GO:0043168|GO:0005543|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:1990089|GO:0045184|GO:0008104|GO:0061024|GO:0051649|GO:0010008|GO:0030030|GO:0048869|GO:0010033|GO:0010256|GO:0005768|GO:0016192|GO:0031175|GO:0090150|GO:0046872|GO:1990090|GO:0015031|GO:0007009|GO:0046907|GO:0055037|GO:0005770|GO:0072657|GO:0070848|GO:0034613|GO:0007399|GO:0071310|GO:0070300|GO:0051020|GO:0030154|GO:0031902|GO:0055038|GO:0048666|GO:0030182|GO:0033365|GO:0032456|GO:0071363|GO:0006605|GO:0006886|GO:1990126|GO:0016197|GO:0031267|GO:0097320|GO:0046914|GO:0006897|GO:0022008|GO:0006612|GO:0017016|GO:0032458|GO:0048699|GO:0006898|GO:0036010|GO:0008270|GO:0017137 developmental process|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|intracellular organelle|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|lipid binding|intracellular|protein binding|endomembrane system|anatomical structure development|organelle membrane|identical protein binding|cell development|transport|multicellular organism development|anion binding|phospholipid binding|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|response to nerve growth factor|establishment of protein localization|protein localization|membrane organization|establishment of localization in cell|endosome membrane|cell projection organization|cellular developmental process|response to organic substance|endomembrane system organization|endosome|vesicle-mediated transport|neuron projection development|establishment of protein localization to membrane|metal ion binding|cellular response to nerve growth factor stimulus|protein transport|plasma membrane organization|intracellular transport|recycling endosome|late endosome|protein localization to membrane|response to growth factor|cellular protein localization|nervous system development|cellular response to organic substance|phosphatidic acid binding|GTPase binding|cell differentiation|late endosome membrane|recycling endosome membrane|neuron development|neuron differentiation|protein localization to organelle|endocytic recycling|cellular response to growth factor stimulus|protein targeting|intracellular protein transport|retrograde transport, endosome to plasma membrane|endosomal transport|small GTPase binding|membrane tubulation|transition metal ion binding|endocytosis|neurogenesis|protein targeting to membrane|Ras GTPase binding|slow endocytic recycling|generation of neurons|receptor-mediated endocytosis|protein localization to endosome|zinc ion binding|Rab GTPase binding - - - - 22:37905657-37942822 536 643 755 1582 1704 1629 4.30607368379747 4.69469229545708 5.46861946768592 11.387292510934 11.2319160263794 12.2649651830074 4.82312848231349 11.6280579067736 -1.26956901373095 6.99742464939159e-10 1.58981062011367e-08 DOWN ENSG00000145555 MYO10 myosin X [Source:HGNC Symbol;Acc:HGNC:7593] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0043167|GO:0006955|GO:0051641|GO:0044297|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0031252|GO:0016787|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0002757|GO:0016337|GO:0008360|GO:0006935|GO:0045087|GO:0048468|GO:0043025|GO:0006810|GO:0005938|GO:0007275|GO:0043168|GO:0006952|GO:0030155|GO:0005543|GO:0001882|GO:0051128|GO:0016817|GO:0022607|GO:0098609|GO:0043231|GO:0005737|GO:0001726|GO:0006928|GO:0032403|GO:0043005|GO:0030027|GO:0036477|GO:0016459|GO:0050776|GO:0005516|GO:0007154|GO:0060491|GO:0007165|GO:0050778|GO:0051649|GO:0045785|GO:0032433|GO:0008092|GO:0000166|GO:0030030|GO:0031253|GO:0048869|GO:0016192|GO:0005730|GO:0000902|GO:0006909|GO:0005829|GO:0031175|GO:0031344|GO:0007166|GO:0035639|GO:0035091|GO:0001883|GO:0003779|GO:0000904|GO:0016818|GO:0046907|GO:0032549|GO:0002429|GO:0022407|GO:0031981|GO:0030031|GO:0022604|GO:0030175|GO:0002764|GO:0031527|GO:0051015|GO:0032990|GO:0007399|GO:0097485|GO:0017076|GO:0030154|GO:0022409|GO:0048858|GO:0005856|GO:0005634|GO:0038096|GO:0030507|GO:0051489|GO:0048666|GO:0030182|GO:0015629|GO:0007411|GO:0005524|GO:0030554|GO:0002768|GO:0061564|GO:0046847|GO:1901981|GO:0002431|GO:0006897|GO:0022008|GO:0048667|GO:0030705|GO:0048812|GO:0016462|GO:0007409|GO:0048699|GO:0017111|GO:0038093|GO:0005547|GO:0016887|GO:0038094|GO:0003774|GO:0000146|GO:0042623|GO:0060002|GO:0030898 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|ion binding|immune response|cellular localization|cell body|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|cell leading edge|hydrolase activity|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|anatomical structure development|immune response-activating signal transduction|single organismal cell-cell adhesion|regulation of cell shape|chemotaxis|innate immune response|cell development|neuronal cell body|transport|cell cortex|multicellular organism development|anion binding|defense response|regulation of cell adhesion|phospholipid binding|nucleoside binding|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|cellular component assembly|cell-cell adhesion|intracellular membrane-bounded organelle|cytoplasm|ruffle|movement of cell or subcellular component|protein complex binding|neuron projection|lamellipodium|somatodendritic compartment|myosin complex|regulation of immune response|calmodulin binding|cell communication|regulation of cell projection assembly|signal transduction|positive regulation of immune response|establishment of localization in cell|positive regulation of cell adhesion|filopodium tip|cytoskeletal protein binding|nucleotide binding|cell projection organization|cell projection membrane|cellular developmental process|vesicle-mediated transport|nucleolus|cell morphogenesis|phagocytosis|cytosol|neuron projection development|regulation of cell projection organization|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|phosphatidylinositol binding|purine nucleoside binding|actin binding|cell morphogenesis involved in differentiation|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|immune response-activating cell surface receptor signaling pathway|regulation of cell-cell adhesion|nuclear lumen|cell projection assembly|regulation of cell morphogenesis|filopodium|immune response-regulating signaling pathway|filopodium membrane|actin filament binding|cell part morphogenesis|nervous system development|neuron projection guidance|purine nucleotide binding|cell differentiation|positive regulation of cell-cell adhesion|cell projection morphogenesis|cytoskeleton|nucleus|Fc-gamma receptor signaling pathway involved in phagocytosis|spectrin binding|regulation of filopodium assembly|neuron development|neuron differentiation|actin cytoskeleton|axon guidance|ATP binding|adenyl nucleotide binding|immune response-regulating cell surface receptor signaling pathway|axon development|filopodium assembly|phosphatidylinositol phosphate binding|Fc receptor mediated stimulatory signaling pathway|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|cytoskeleton-dependent intracellular transport|neuron projection morphogenesis|pyrophosphatase activity|axonogenesis|generation of neurons|nucleoside-triphosphatase activity|Fc receptor signaling pathway|phosphatidylinositol-3,4,5-trisphosphate binding|ATPase activity|Fc-gamma receptor signaling pathway|motor activity|microfilament motor activity|ATPase activity, coupled|plus-end directed microfilament motor activity|actin-dependent ATPase activity K12559 myosin X[-] hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) 5:16661914-16936276 769 875 1270 2466 2641 2539 2.85846878369267 2.95593697284075 4.25622648914906 8.21292300762305 8.05458664392222 8.84501642349694 3.35687741522749 8.37084202501407 -1.31825289673582 7.01617550262759e-10 1.59285858141022e-08 DOWN ENSG00000111641 NOP2 NOP2 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:7867] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0008284|GO:0042127|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0022613|GO:0005730|GO:0008168|GO:0003723|GO:0042254|GO:0031981|GO:0010467|GO:0016070|GO:0005634|GO:0006364|GO:0006396|GO:0034660|GO:0044822|GO:0008757|GO:0016072 cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|nucleolus|methyltransferase activity|RNA binding|ribosome biogenesis|nuclear lumen|gene expression|RNA metabolic process|nucleus|rRNA processing|RNA processing|ncRNA metabolic process|poly(A) RNA binding|S-adenosylmethionine-dependent methyltransferase activity|rRNA metabolic process - - - - 12:6556863-6568691 3394 3495 1974 1016 1178 628 17.1278383924118 16.0294210307675 8.98156552558888 4.59390498889452 4.87757412064701 2.97015526408908 14.0462749829227 4.14721145787687 1.75997406978039 7.06400622196161e-10 1.60249879749576e-08 UP ENSG00000132334 PTPRE protein tyrosine phosphatase, receptor type, E [Source:HGNC Symbol;Acc:HGNC:9669] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0004872|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0071704|GO:0044237|GO:0038023|GO:0023051|GO:0043227|GO:0071944|GO:0023057|GO:0016787|GO:0031224|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0042802|GO:0016788|GO:1900076|GO:0043231|GO:0010243|GO:0004888|GO:0005737|GO:0001775|GO:0009966|GO:0046983|GO:0010646|GO:0050865|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0016021|GO:0019538|GO:0010033|GO:0007166|GO:0043412|GO:0033003|GO:1901652|GO:0071417|GO:0036211|GO:0045576|GO:0043434|GO:0006796|GO:0044267|GO:0071310|GO:0046627|GO:0046626|GO:0032870|GO:0005634|GO:0042803|GO:0042578|GO:0016311|GO:1901653|GO:0007167|GO:0071375|GO:0016791|GO:0032868|GO:0006464|GO:0005001|GO:0006470|GO:0004721|GO:0032869|GO:0007185|GO:0007169|GO:0035335|GO:0004725|GO:0008286 signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|receptor activity|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|organic substance metabolic process|cellular metabolic process|signaling receptor activity|regulation of signaling|membrane-bounded organelle|cell periphery|negative regulation of signaling|hydrolase activity|intrinsic component of membrane|intracellular|regulation of immune system process|protein binding|plasma membrane|identical protein binding|hydrolase activity, acting on ester bonds|regulation of cellular response to insulin stimulus|intracellular membrane-bounded organelle|response to organonitrogen compound|transmembrane signaling receptor activity|cytoplasm|cell activation|regulation of signal transduction|protein dimerization activity|regulation of cell communication|regulation of cell activation|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|integral component of membrane|protein metabolic process|response to organic substance|cell surface receptor signaling pathway|macromolecule modification|regulation of mast cell activation|response to peptide|cellular response to organonitrogen compound|protein modification process|mast cell activation|response to peptide hormone|phosphate-containing compound metabolic process|cellular protein metabolic process|cellular response to organic substance|negative regulation of insulin receptor signaling pathway|regulation of insulin receptor signaling pathway|cellular response to hormone stimulus|nucleus|protein homodimerization activity|phosphoric ester hydrolase activity|dephosphorylation|cellular response to peptide|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|phosphatase activity|response to insulin|cellular protein modification process|transmembrane receptor protein tyrosine phosphatase activity|protein dephosphorylation|phosphoprotein phosphatase activity|cellular response to insulin stimulus|transmembrane receptor protein tyrosine phosphatase signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity|insulin receptor signaling pathway - - - - 10:127907061-128085855 27 19 59 157 176 216 0.138740780983859 0.0887323234171284 0.273340472561055 0.722827343390004 0.742024613709654 1.04020659017486 0.166937858987347 0.835019515758173 -2.32249874282866 7.07531029080045e-10 1.60384444511433e-08 DOWN ENSG00000077348 EXOSC5 exosome component 5 [Source:HGNC Symbol;Acc:HGNC:24662] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0000785|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:0000178|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0006952|GO:0046483|GO:0098542|GO:0043231|GO:0005737|GO:0009615|GO:0006139|GO:0051607|GO:0035327|GO:0022613|GO:0043487|GO:0005730|GO:0005829|GO:0010468|GO:0003723|GO:0043412|GO:0044265|GO:0042254|GO:0000177|GO:0031981|GO:0004518|GO:0000176|GO:0006259|GO:0005694|GO:0010467|GO:0019439|GO:0016070|GO:0005634|GO:0043488|GO:0006401|GO:0006364|GO:0090501|GO:0006396|GO:0034660|GO:0010608|GO:0006304|GO:0004527|GO:0016071|GO:0004540|GO:0090305|GO:0004532|GO:0016074|GO:0008408|GO:0006402|GO:0031125|GO:0016073|GO:0016072|GO:0090503|GO:0045006|GO:0071025|GO:0031123|GO:0000956|GO:0016075|GO:0000175|GO:0016896|GO:0016180|GO:0000291|GO:0071028|GO:0000288|GO:0071051|GO:0034475|GO:0034427|GO:0043928 macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|chromatin|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|hydrolase activity|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|exosome (RNase complex)|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|defense response|heterocycle metabolic process|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|response to virus|nucleobase-containing compound metabolic process|defense response to virus|transcriptionally active chromatin|ribonucleoprotein complex biogenesis|regulation of RNA stability|nucleolus|cytosol|regulation of gene expression|RNA binding|macromolecule modification|cellular macromolecule catabolic process|ribosome biogenesis|cytoplasmic exosome (RNase complex)|nuclear lumen|nuclease activity|nuclear exosome (RNase complex)|DNA metabolic process|chromosome|gene expression|aromatic compound catabolic process|RNA metabolic process|nucleus|regulation of mRNA stability|RNA catabolic process|rRNA processing|RNA phosphodiester bond hydrolysis|RNA processing|ncRNA metabolic process|posttranscriptional regulation of gene expression|DNA modification|exonuclease activity|mRNA metabolic process|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|exoribonuclease activity|snoRNA metabolic process|3'-5' exonuclease activity|mRNA catabolic process|rRNA 3'-end processing|snRNA metabolic process|rRNA metabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic|DNA deamination|RNA surveillance|RNA 3'-end processing|nuclear-transcribed mRNA catabolic process|rRNA catabolic process|3'-5'-exoribonuclease activity|exoribonuclease activity, producing 5'-phosphomonoesters|snRNA processing|nuclear-transcribed mRNA catabolic process, exonucleolytic|nuclear mRNA surveillance|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|polyadenylation-dependent snoRNA 3'-end processing|U4 snRNA 3'-end processing|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay K12590 exosome complex component RRP46[-] hsa03018 RNA degradation - Homo sapiens (human) 19:41386374-41397479 869 1103 994 428 550 361 21.6673770014919 24.994355117091 22.3453348522699 9.56154644369285 11.251674448959 8.43573715249331 23.0023556569509 9.74965268171505 1.23835888342148 7.30551511764272e-10 1.65477123157895e-08 UP ENSG00000248405 PRR5-ARHGAP8 PRR5-ARHGAP8 readthrough [Source:HGNC Symbol;Acc:HGNC:34512] GO:0023052|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0007154|GO:0007165 signaling|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|cell communication|signal transduction - - - - 22:44702233-44862706 14 5 22 95 79 179 0.248953278588036 0.0808111953376615 0.352702462436893 1.51356374658299 1.15259398021622 2.98306417153594 0.22748897878753 1.88307396611172 -3.04922111180594 7.4293916154585e-10 1.6815546420614e-08 DOWN ENSG00000164758 MED30 mediator complex subunit 30 [Source:HGNC Symbol;Acc:HGNC:23032] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0016592|GO:0001076|GO:0006139|GO:0007154|GO:0007165|GO:0008134|GO:0009725|GO:0019787|GO:0000151|GO:0044249|GO:0019827|GO:0019538|GO:0010033|GO:0031323|GO:0003713|GO:0042809|GO:0010468|GO:0034645|GO:0033993|GO:0043412|GO:0001104|GO:0004842|GO:0051427|GO:0051252|GO:0010628|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0046966|GO:0014070|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0009755|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0043401|GO:0045893|GO:0061630|GO:0032774|GO:2001141|GO:0035257|GO:0071383|GO:0071407|GO:0030518|GO:0030374|GO:0006464|GO:0071396|GO:0006351|GO:0006355|GO:0006366|GO:0006352|GO:0006357|GO:1903506|GO:0030521|GO:0032446|GO:0006367|GO:0016567 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|mediator complex|transcription factor activity, RNA polymerase II transcription factor binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|transcription factor binding|response to hormone|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|response to organic substance|regulation of cellular metabolic process|transcription coactivator activity|vitamin D receptor binding|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|macromolecule modification|RNA polymerase II transcription cofactor activity|ubiquitin-protein transferase activity|hormone receptor binding|regulation of RNA metabolic process|positive regulation of gene expression|protein modification process|nuclear lumen|transferase complex|nucleoplasm|thyroid hormone receptor binding|response to organic cyclic compound|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|ligand-dependent nuclear receptor transcription coactivator activity|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|androgen receptor signaling pathway|protein modification by small protein conjugation|transcription initiation from RNA polymerase II promoter|protein ubiquitination K15143 mediator of RNA polymerase II transcription subunit 30[-] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) 8:117520713-117540262 802 832 866 409 419 362 23.3364738471346 22.0020963303585 22.719206628435 10.6630617525022 10.0032794708707 9.8718519321272 22.685925601976 10.1793977185 1.15614531946237 7.48867580927267e-10 1.6936888455305e-08 UP ENSG00000133315 MACROD1 MACRO domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29598] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0016798|GO:0034641|GO:0044281|GO:0046483|GO:0033554|GO:0043231|GO:0019213|GO:0005737|GO:0006139|GO:0055086|GO:0019538|GO:0043412|GO:0036211|GO:0009116|GO:0005739|GO:0044267|GO:0005634|GO:0006974|GO:0006464|GO:0042278|GO:0051725 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|hydrolase activity, acting on glycosyl bonds|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|deacetylase activity|cytoplasm|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein metabolic process|macromolecule modification|protein modification process|nucleoside metabolic process|mitochondrion|cellular protein metabolic process|nucleus|cellular response to DNA damage stimulus|cellular protein modification process|purine nucleoside metabolic process|protein de-ADP-ribosylation - - - - 11:63998558-64166106 168 166 258 515 603 759 3.28280902289583 2.94798125555954 4.54539694061593 9.01657928834505 9.66768361398947 13.8997865329349 3.5920624063571 10.8613498117565 -1.5963190876005 7.5108162717997e-10 1.69741036319688e-08 DOWN ENSG00000129932 DOHH deoxyhypusine hydroxylase/monooxygenase [Source:HGNC Symbol;Acc:HGNC:28662] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0005515|GO:0043169|GO:0005737|GO:0016705|GO:0004497|GO:0019538|GO:0008612|GO:0055114|GO:0005829|GO:0046872|GO:0043412|GO:0036211|GO:0019135|GO:0044267|GO:0006464|GO:0018193|GO:0043687|GO:0018205 cell|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|protein binding|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|protein metabolic process|peptidyl-lysine modification to peptidyl-hypusine|oxidation-reduction process|cytosol|metal ion binding|macromolecule modification|protein modification process|deoxyhypusine monooxygenase activity|cellular protein metabolic process|cellular protein modification process|peptidyl-amino acid modification|post-translational protein modification|peptidyl-lysine modification - - - - 19:3490821-3500940 596 684 387 199 196 134 8.72319291238843 9.09840171144202 5.10686364853458 2.60963643707466 2.35370417791718 1.83807534629022 7.64281942412168 2.26713865376069 1.75323231821217 7.55279682291955e-10 1.70560662898215e-08 UP ENSG00000104327 CALB1 calbindin 1 [Source:HGNC Symbol;Acc:HGNC:1434] GO:0032502|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0023051|GO:0044297|GO:0009653|GO:0043227|GO:0044708|GO:0008289|GO:0005622|GO:0005515|GO:0007626|GO:0048856|GO:0048646|GO:0050804|GO:0060041|GO:0001822|GO:0009888|GO:0043025|GO:0035295|GO:0043195|GO:0007275|GO:0005496|GO:0048513|GO:0050877|GO:0031982|GO:0050803|GO:0043231|GO:0043178|GO:0043169|GO:0005737|GO:0007267|GO:0007423|GO:0009887|GO:0042592|GO:0043005|GO:0003407|GO:0048729|GO:0072006|GO:0019725|GO:0036477|GO:0019842|GO:0010646|GO:0007154|GO:0070062|GO:0044306|GO:0007611|GO:0010842|GO:0010033|GO:0072044|GO:0035502|GO:0005829|GO:0048167|GO:0072170|GO:0046872|GO:0001654|GO:0030424|GO:0072164|GO:0001655|GO:0048878|GO:0072205|GO:0001656|GO:0007613|GO:0072001|GO:0055082|GO:0043679|GO:0060042|GO:0030425|GO:0005499|GO:0061326|GO:0060993|GO:0060429|GO:0072073|GO:0071310|GO:0050890|GO:0001823|GO:0005634|GO:0072221|GO:0072234|GO:0001657|GO:0043010|GO:0072163|GO:0005509|GO:0072080|GO:0046914|GO:0050801|GO:0007616|GO:0072207|GO:0003338|GO:0007614|GO:0006873|GO:0048592|GO:0072017|GO:0048593|GO:0072286|GO:0072235|GO:0008270|GO:0030003|GO:0007268|GO:0055065|GO:0006875|GO:0006874|GO:0055074|GO:0051480 developmental process|synapse|behavior|signaling|cell|cellular process|extracellular region|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|regulation of signaling|cell body|anatomical structure morphogenesis|membrane-bounded organelle|single-organism behavior|lipid binding|intracellular|protein binding|locomotory behavior|anatomical structure development|anatomical structure formation involved in morphogenesis|modulation of synaptic transmission|retina development in camera-type eye|kidney development|tissue development|neuronal cell body|tube development|terminal bouton|multicellular organism development|steroid binding|animal organ development|neurological system process|vesicle|regulation of synapse structure or activity|intracellular membrane-bounded organelle|alcohol binding|cation binding|cytoplasm|cell-cell signaling|sensory organ development|organ morphogenesis|homeostatic process|neuron projection|neural retina development|tissue morphogenesis|nephron development|cellular homeostasis|somatodendritic compartment|vitamin binding|regulation of cell communication|cell communication|extracellular exosome|neuron projection terminus|learning or memory|retina layer formation|response to organic substance|collecting duct development|metanephric part of ureteric bud development|cytosol|regulation of synaptic plasticity|metanephric tubule development|metal ion binding|eye development|axon|mesonephric tubule development|urogenital system development|chemical homeostasis|metanephric collecting duct development|metanephros development|memory|renal system development|cellular chemical homeostasis|axon terminus|retina morphogenesis in camera-type eye|dendrite|vitamin D binding|renal tubule development|kidney morphogenesis|epithelium development|kidney epithelium development|cellular response to organic substance|cognition|mesonephros development|nucleus|metanephric distal convoluted tubule development|metanephric nephron tubule development|ureteric bud development|camera-type eye development|mesonephric epithelium development|calcium ion binding|nephron tubule development|transition metal ion binding|ion homeostasis|long-term memory|metanephric epithelium development|metanephros morphogenesis|short-term memory|cellular ion homeostasis|eye morphogenesis|distal tubule development|camera-type eye morphogenesis|metanephric connecting tubule development|metanephric distal tubule development|zinc ion binding|cellular cation homeostasis|synaptic transmission|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration K14757 calbindin D28[-] hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) 8:90058608-90095475 61 57 78 13 19 17 0.383111005341313 0.3253490760157 0.441672250646913 0.0731527146215776 0.0979078711987242 0.100062035418806 0.383377444001309 0.0903742070797026 2.08478246919727 7.65579893766862e-10 1.72725409420483e-08 UP ENSG00000165923 AGBL2 ATP/GTP binding protein-like 2 [Source:HGNC Symbol;Acc:HGNC:26296] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0042995|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0005622|GO:0005929|GO:0043169|GO:0008233|GO:0005737|GO:0036064|GO:0019538|GO:0005829|GO:0005813|GO:0046872|GO:0043412|GO:0005815|GO:0005814|GO:0036211|GO:0006508|GO:0044267|GO:0005856|GO:0008237|GO:0015630|GO:0008238|GO:0046914|GO:0006464|GO:0004180|GO:0018193|GO:0008235|GO:0008270|GO:0004181|GO:0035608|GO:0035610 cell|cellular process|metabolic process|binding|catalytic activity|cell projection|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|intracellular|cilium|cation binding|peptidase activity|cytoplasm|ciliary basal body|protein metabolic process|cytosol|centrosome|metal ion binding|macromolecule modification|microtubule organizing center|centriole|protein modification process|proteolysis|cellular protein metabolic process|cytoskeleton|metallopeptidase activity|microtubule cytoskeleton|exopeptidase activity|transition metal ion binding|cellular protein modification process|carboxypeptidase activity|peptidyl-amino acid modification|metalloexopeptidase activity|zinc ion binding|metallocarboxypeptidase activity|protein deglutamylation|protein side chain deglutamylation - - - - 11:47659591-47715389 10 14 13 63 59 73 0.0759188182335141 0.0966000031240713 0.0889858647397667 0.428553549286302 0.367530041188522 0.519426216950417 0.0871682286991174 0.438503269141747 -2.33071329961994 7.66022784460106e-10 1.72725409420483e-08 DOWN ENSG00000134363 FST follistatin [Source:HGNC Symbol;Acc:HGNC:3971] GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0023057|GO:0009058|GO:0050793|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:0045684|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0046483|GO:0001942|GO:0032403|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0001948|GO:0048869|GO:0042634|GO:0044249|GO:0043395|GO:0031324|GO:0042635|GO:0031323|GO:0045682|GO:0010468|GO:0034645|GO:0090101|GO:0007166|GO:0030097|GO:0010629|GO:0022405|GO:0051252|GO:0051798|GO:0043394|GO:0043588|GO:0060429|GO:0048185|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0051797|GO:0042633|GO:0032926|GO:0032925|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0008544|GO:0007167|GO:0002244|GO:0006351|GO:0006355|GO:0098773|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0007178|GO:0000122|GO:0032924 developmental process|signal transducer activity|immune system process|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|negative regulation of signaling|biosynthetic process|regulation of developmental process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|positive regulation of epidermis development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|heterocycle metabolic process|hair follicle development|protein complex binding|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|glycoprotein binding|cellular developmental process|regulation of hair cycle|cellular biosynthetic process|heparan sulfate proteoglycan binding|negative regulation of cellular metabolic process|positive regulation of hair cycle|regulation of cellular metabolic process|regulation of epidermis development|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|hemopoiesis|negative regulation of gene expression|hair cycle process|regulation of RNA metabolic process|positive regulation of hair follicle development|proteoglycan binding|skin development|epithelium development|activin binding|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|regulation of hair follicle development|hair cycle|negative regulation of activin receptor signaling pathway|regulation of activin receptor signaling pathway|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|epidermis development|enzyme linked receptor protein signaling pathway|hematopoietic progenitor cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|skin epidermis development|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|activin receptor signaling pathway K04661 follistatin[-] hsa04350 TGF-beta signaling pathway - Homo sapiens (human) 5:53480409-53487134 76 64 108 21 23 21 0.96430777181276 0.738006696513085 1.23548508889396 0.238738268275786 0.239439106897 0.249711513261504 0.979266519073268 0.242629629478097 2.01294581950223 7.69280027049973e-10 1.73328950396603e-08 UP ENSG00000100105 PATZ1 POZ (BTB) and AT hook containing zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:13071] GO:0032502|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0007155|GO:0043227|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0016337|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0070489|GO:0034641|GO:0031325|GO:0046483|GO:0098609|GO:0043231|GO:0048608|GO:0043169|GO:0000981|GO:0001775|GO:0007548|GO:0009890|GO:0003682|GO:0006139|GO:0046649|GO:0008406|GO:0007276|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0008584|GO:0048232|GO:0046872|GO:0046661|GO:0061458|GO:0030097|GO:0030098|GO:0010629|GO:0051252|GO:0010628|GO:0031981|GO:0007159|GO:0005654|GO:0042110|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0046546|GO:0002521|GO:0007283|GO:0000975|GO:0045893|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0030217|GO:0001077|GO:1902679|GO:0070486|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0071593|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|immune system development|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|single organismal cell-cell adhesion|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cell-cell adhesion|intracellular membrane-bounded organelle|reproductive structure development|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cell activation|sex differentiation|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|lymphocyte activation|gonad development|gamete generation|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gonad development|male gamete generation|metal ion binding|male sex differentiation|reproductive system development|hemopoiesis|lymphocyte differentiation|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|leukocyte cell-cell adhesion|nucleoplasm|T cell activation|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|development of primary male sexual characteristics|leukocyte differentiation|spermatogenesis|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|T cell differentiation|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of RNA biosynthetic process|leukocyte aggregation|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|lymphocyte aggregation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 22:31325804-31346232 184 171 233 601 612 499 1.39397792984925 1.17737593233145 1.5915089428391 4.07953068366292 3.80415028869073 3.54297391365053 1.3876209350066 3.80888496200139 -1.4567552036957 7.73908349263084e-10 1.74240270429111e-08 DOWN ENSG00000174007 CEP19 centrosomal protein 19kDa [Source:HGNC Symbol;Acc:HGNC:28209] GO:0005623|GO:0005488|GO:0042995|GO:0043229|GO:0005622|GO:0005515|GO:0005929|GO:0005737|GO:0036064|GO:0005813|GO:0005815|GO:0005814|GO:0005856|GO:0000922|GO:0005819|GO:0015630 cell|binding|cell projection|intracellular organelle|intracellular|protein binding|cilium|cytoplasm|ciliary basal body|centrosome|microtubule organizing center|centriole|cytoskeleton|spindle pole|spindle|microtubule cytoskeleton - - - - 3:196706277-196712293 456 522 513 214 206 224 9.56300880705245 9.94901646445005 9.69976469608429 4.02106541072586 3.54457518005382 4.40256163656072 9.73726332252893 3.9894007424468 1.28734430492494 7.81706920290754e-10 1.75863439324493e-08 UP ENSG00000010072 SPRTN SprT-like N-terminal domain [Source:HGNC Symbol;Acc:HGNC:25356] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006281|GO:0032182|GO:0006725|GO:0009314|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0003677|GO:0034645|GO:0046872|GO:0043412|GO:0043130|GO:0019985|GO:0036211|GO:0031981|GO:0051247|GO:0005654|GO:0006259|GO:0005694|GO:0032270|GO:0006301|GO:0044267|GO:0051246|GO:0009059|GO:0005634|GO:0009416|GO:0006974|GO:0031401|GO:0009411|GO:0070987|GO:0016604|GO:0031593|GO:0006464|GO:0071897|GO:0016607|GO:0070530|GO:0032446|GO:0031398|GO:0031396|GO:0016567 cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|DNA repair|ubiquitin-like protein binding|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|DNA binding|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|ubiquitin binding|translesion synthesis|protein modification process|nuclear lumen|positive regulation of protein metabolic process|nucleoplasm|DNA metabolic process|chromosome|positive regulation of cellular protein metabolic process|postreplication repair|cellular protein metabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|response to light stimulus|cellular response to DNA damage stimulus|positive regulation of protein modification process|response to UV|error-free translesion synthesis|nuclear body|polyubiquitin binding|cellular protein modification process|DNA biosynthetic process|nuclear speck|K63-linked polyubiquitin binding|protein modification by small protein conjugation|positive regulation of protein ubiquitination|regulation of protein ubiquitination|protein ubiquitination - - - - 1:231337104-231355023 159 184 187 487 517 502 1.16429953062888 1.22452003960132 1.23459579252522 3.19517777112109 3.10618298139732 3.4450936509201 1.20780512091847 3.2488181344795 -1.42752729040942 7.94384279117951e-10 1.78580935758941e-08 DOWN ENSG00000142188 TMEM50B transmembrane protein 50B [Source:HGNC Symbol;Acc:HGNC:1280] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0043231|GO:0005737|GO:0005783|GO:0016021 cell|membrane|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane - - - - 21:33432485-33480011 84 86 119 319 298 308 0.696341770941223 0.647920775670922 0.889420053524501 2.36936818708002 2.02688413072467 2.39289208711492 0.744560866712215 2.2630481349732 -1.6038055741618 8.05691305657137e-10 1.80986517976585e-08 DOWN ENSG00000085511 MAP3K4 mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856] GO:0032502|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0006807|GO:0006950|GO:0005057|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0003006|GO:0023051|GO:0016043|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0001890|GO:0007530|GO:0006725|GO:0009314|GO:0051130|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0032204|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0032206|GO:0060717|GO:0000723|GO:0048608|GO:0043169|GO:0005737|GO:0042592|GO:0009966|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0004702|GO:0008219|GO:0050790|GO:0000166|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031323|GO:0006996|GO:0000165|GO:0051276|GO:1902533|GO:0032268|GO:0007004|GO:0010468|GO:0034645|GO:0046872|GO:0010833|GO:0035639|GO:0043412|GO:0061458|GO:0001883|GO:0030238|GO:0007538|GO:0051347|GO:0036211|GO:0000278|GO:1904358|GO:0032549|GO:0031098|GO:0007346|GO:0051247|GO:0048471|GO:0006259|GO:0016301|GO:0032270|GO:0012501|GO:0051054|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0017076|GO:0031328|GO:1904355|GO:0051246|GO:1904356|GO:0009059|GO:0030154|GO:0016233|GO:1902531|GO:0004709|GO:0016773|GO:0010557|GO:0009416|GO:0043067|GO:0060718|GO:0010638|GO:2001252|GO:0070304|GO:0019100|GO:0031401|GO:0032200|GO:0006260|GO:0009411|GO:0043408|GO:0051972|GO:0005524|GO:0051973|GO:0030554|GO:0016310|GO:0033044|GO:0032212|GO:2000278|GO:0043410|GO:0006275|GO:0032872|GO:0042981|GO:0004672|GO:2000573|GO:0045740|GO:0006464|GO:0051403|GO:0071897|GO:0032210|GO:0043549|GO:0006915|GO:0033674|GO:0000186|GO:0006278|GO:0045859|GO:0045860|GO:0043406|GO:1900744|GO:0046328|GO:0038066|GO:0006468|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0004674|GO:0032874|GO:0001934|GO:0042327|GO:0010225|GO:0046330|GO:0043507|GO:1900745|GO:0071902|GO:0071900|GO:0043506|GO:0032147 developmental process|signal transducer activity|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|response to stress|receptor signaling protein activity|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|cellular component organization|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|placenta development|sex determination|cellular aromatic compound metabolic process|response to radiation|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|regulation of telomere maintenance|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of telomere maintenance|chorion development|telomere maintenance|reproductive structure development|cation binding|cytoplasm|homeostatic process|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|receptor signaling protein serine/threonine kinase activity|cell death|regulation of catalytic activity|nucleotide binding|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|organelle organization|MAPK cascade|chromosome organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|telomere maintenance via telomerase|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|telomere maintenance via telomere lengthening|purine ribonucleoside triphosphate binding|macromolecule modification|reproductive system development|purine nucleoside binding|male sex determination|primary sex determination|positive regulation of transferase activity|protein modification process|mitotic cell cycle|positive regulation of telomere maintenance via telomere lengthening|ribonucleoside binding|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|positive regulation of protein metabolic process|perinuclear region of cytoplasm|DNA metabolic process|kinase activity|positive regulation of cellular protein metabolic process|programmed cell death|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|purine nucleotide binding|positive regulation of cellular biosynthetic process|positive regulation of telomere capping|regulation of protein metabolic process|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|cell differentiation|telomere capping|regulation of intracellular signal transduction|MAP kinase kinase kinase activity|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|response to light stimulus|regulation of programmed cell death|chorionic trophoblast cell differentiation|positive regulation of organelle organization|positive regulation of chromosome organization|positive regulation of stress-activated protein kinase signaling cascade|male germ-line sex determination|positive regulation of protein modification process|telomere organization|DNA replication|response to UV|regulation of MAPK cascade|regulation of telomerase activity|ATP binding|positive regulation of telomerase activity|adenyl nucleotide binding|phosphorylation|regulation of chromosome organization|positive regulation of telomere maintenance via telomerase|regulation of DNA biosynthetic process|positive regulation of MAPK cascade|regulation of DNA replication|regulation of stress-activated MAPK cascade|regulation of apoptotic process|protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|cellular protein modification process|stress-activated MAPK cascade|DNA biosynthetic process|regulation of telomere maintenance via telomerase|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|activation of MAPKK activity|RNA-dependent DNA replication|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of p38MAPK cascade|regulation of JNK cascade|p38MAPK cascade|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|positive regulation of phosphorylation|response to UV-C|positive regulation of JNK cascade|positive regulation of JUN kinase activity|positive regulation of p38MAPK cascade|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|activation of protein kinase activity K04428 mitogen-activated protein kinase kinase kinase 4[2.7.11.25] hsa04010|hsa04912 MAPK signaling pathway - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human) 6:160991727-161117385 143 138 229 533 587 463 0.861251294908841 0.755355273470548 1.2434914253982 2.87619177273155 2.90067346877265 2.61338259098813 0.953365997925863 2.79674927749744 -1.55264884783016 8.127250483473e-10 1.82429275138047e-08 DOWN ENSG00000267260 CTD-2162K18.4 - - - - - - - 19:36773153-36777078 28 17 31 4 2 1 0.793512028644839 0.437866410257232 0.792101858061398 0.10157187917762 0.0465017363059982 0.0265567890135089 0.674493432321156 0.0582101348323757 3.53446213100598 8.15902668883674e-10 1.83004945731429e-08 UP ENSG00000140521 POLG polymerase (DNA directed), gamma [Source:HGNC Symbol;Acc:HGNC:9179] GO:0032502|GO:0032991|GO:0045202|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0044877|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0042645|GO:0006281|GO:0006725|GO:0009314|GO:1901360|GO:0043195|GO:0003676|GO:0034641|GO:0016788|GO:0016772|GO:0031982|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0005737|GO:0042592|GO:0043005|GO:0019725|GO:0003682|GO:0006139|GO:0070062|GO:0044306|GO:0044249|GO:0010033|GO:0055093|GO:0006996|GO:0007568|GO:0003677|GO:0009743|GO:0034645|GO:0030424|GO:0005760|GO:0007005|GO:0048878|GO:0006284|GO:0055082|GO:0043679|GO:0002020|GO:0004518|GO:1990234|GO:0005759|GO:0006259|GO:0005739|GO:0010212|GO:0071310|GO:0009059|GO:0016779|GO:0009416|GO:0006974|GO:0000002|GO:0071322|GO:0010332|GO:0034061|GO:0006260|GO:0001678|GO:0034284|GO:0004527|GO:0032042|GO:0071897|GO:0033500|GO:0006287|GO:0071333|GO:0042593|GO:0006261|GO:0008408|GO:0006264|GO:0003887|GO:0009749 developmental process|macromolecular complex|synapse|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|mitochondrial nucleoid|DNA repair|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|terminal bouton|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|transferase activity, transferring phosphorus-containing groups|vesicle|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|homeostatic process|neuron projection|cellular homeostasis|chromatin binding|nucleobase-containing compound metabolic process|extracellular exosome|neuron projection terminus|cellular biosynthetic process|response to organic substance|response to hyperoxia|organelle organization|aging|DNA binding|response to carbohydrate|cellular macromolecule biosynthetic process|axon|gamma DNA polymerase complex|mitochondrion organization|chemical homeostasis|base-excision repair|cellular chemical homeostasis|axon terminus|protease binding|nuclease activity|transferase complex|mitochondrial matrix|DNA metabolic process|mitochondrion|response to ionizing radiation|cellular response to organic substance|macromolecule biosynthetic process|nucleotidyltransferase activity|response to light stimulus|cellular response to DNA damage stimulus|mitochondrial genome maintenance|cellular response to carbohydrate stimulus|response to gamma radiation|DNA polymerase activity|DNA replication|cellular glucose homeostasis|response to monosaccharide|exonuclease activity|mitochondrial DNA metabolic process|DNA biosynthetic process|carbohydrate homeostasis|base-excision repair, gap-filling|cellular response to glucose stimulus|glucose homeostasis|DNA-dependent DNA replication|3'-5' exonuclease activity|mitochondrial DNA replication|DNA-directed DNA polymerase activity|response to glucose K02332 DNA polymerase gamma 1[2.7.7.7] hsa01100 Metabolic pathways - Homo sapiens (human) 15:89316305-89334861 2069 2237 1997 999 1007 993 15.1505728247428 14.8872575283109 13.1844167488537 6.55438134514745 6.050149638924 6.81469933953117 14.4074157006358 6.47307677453421 1.15428805807541 8.21136160810414e-10 1.84040532618875e-08 UP ENSG00000105792 CFAP69 cilia and flagella associated protein 69 [Source:HGNC Symbol;Acc:HGNC:26107] GO:0005488 binding - - - - 7:90245174-90311063 16 14 40 105 124 157 0.0856259092237508 0.0680906513169143 0.192998587646755 0.503462332423626 0.544466620439268 0.787426376347358 0.115571716062473 0.611785109736751 -2.40423662412285 8.24400468232507e-10 1.84465018952478e-08 DOWN ENSG00000144455 SUMF1 sulfatase modifying factor 1 [Source:HGNC Symbol;Acc:HGNC:20376] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0042802|GO:0044255|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0046983|GO:0006629|GO:0005783|GO:0019538|GO:0055114|GO:0006665|GO:0046872|GO:0043412|GO:0006643|GO:0036211|GO:0044267|GO:0005788|GO:0042803|GO:0006687|GO:0006664|GO:0006464|GO:0043687 cell|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|endomembrane system|identical protein binding|cellular lipid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein dimerization activity|lipid metabolic process|endoplasmic reticulum|protein metabolic process|oxidation-reduction process|sphingolipid metabolic process|metal ion binding|macromolecule modification|membrane lipid metabolic process|protein modification process|cellular protein metabolic process|endoplasmic reticulum lumen|protein homodimerization activity|glycosphingolipid metabolic process|glycolipid metabolic process|cellular protein modification process|post-translational protein modification K13444 sulfatase modifying factor 1[-] hsa04142 Lysosome - Homo sapiens (human) 3:3700814-4467281 287 321 332 764 847 847 2.11253832985249 2.14737298564403 2.2033068965743 5.03864395799382 5.11533189090384 5.84298418417975 2.15440607069027 5.3323200110258 -1.30747316397295 8.24883768679434e-10 1.84465018952478e-08 DOWN ENSG00000232956 SNHG15 small nucleolar RNA host gene 15 [Source:HGNC Symbol;Acc:HGNC:27797] - - - - - - 7:44983023-44986961 1320 1249 534 299 295 159 11.7671929822565 10.1190840038729 4.29194858697497 2.38818724718704 2.15769007259854 1.32838983406614 8.72607519103479 1.95808905128391 2.15588652693012 8.24312113075568e-10 1.84465018952478e-08 UP ENSG00000159840 ZYX zyxin [Source:HGNC Symbol;Acc:HGNC:13200] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0030055|GO:0050794|GO:0043229|GO:0006950|GO:0043167|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0016032|GO:0003676|GO:0005924|GO:0006952|GO:0005912|GO:0022607|GO:0005887|GO:0043231|GO:0043169|GO:0005737|GO:0007267|GO:0009611|GO:0071559|GO:0031589|GO:0031226|GO:0007154|GO:0007165|GO:0005913|GO:0016021|GO:0030029|GO:0010033|GO:0006996|GO:0051017|GO:0046872|GO:0003723|GO:0007166|GO:0007010|GO:0050727|GO:0032432|GO:0071560|GO:0007160|GO:0006954|GO:0070848|GO:0030036|GO:0042641|GO:0071310|GO:0005856|GO:0005634|GO:0005925|GO:0015629|GO:0071363|GO:0007229|GO:0007179|GO:0007167|GO:0001725|GO:0046914|GO:0044822|GO:0031032|GO:0030038|GO:0007015|GO:0043149|GO:0007178|GO:0061572|GO:0008270 signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|cell-substrate junction|regulation of cellular process|intracellular organelle|response to stress|ion binding|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|intrinsic component of membrane|intracellular|protein binding|plasma membrane|viral process|nucleic acid binding|cell-substrate adherens junction|defense response|adherens junction|cellular component assembly|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell-cell signaling|response to wounding|response to transforming growth factor beta|cell-substrate adhesion|intrinsic component of plasma membrane|cell communication|signal transduction|cell-cell adherens junction|integral component of membrane|actin filament-based process|response to organic substance|organelle organization|actin filament bundle assembly|metal ion binding|RNA binding|cell surface receptor signaling pathway|cytoskeleton organization|regulation of inflammatory response|actin filament bundle|cellular response to transforming growth factor beta stimulus|cell-matrix adhesion|inflammatory response|response to growth factor|actin cytoskeleton organization|actomyosin|cellular response to organic substance|cytoskeleton|nucleus|focal adhesion|actin cytoskeleton|cellular response to growth factor stimulus|integrin-mediated signaling pathway|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|stress fiber|transition metal ion binding|poly(A) RNA binding|actomyosin structure organization|contractile actin filament bundle assembly|actin filament organization|stress fiber assembly|transmembrane receptor protein serine/threonine kinase signaling pathway|actin filament bundle organization|zinc ion binding K06273 zyxin[-] hsa04510 Focal adhesion - Homo sapiens (human) 7:143381080-143391111 3517 3670 3613 1691 1972 1556 34.2438408016902 32.4755268928787 31.7170169148612 14.7520163908021 15.7537896283207 14.1987054218587 32.8121282031434 14.9015038136605 1.1387712401113 8.29657602973788e-10 1.85393698197451e-08 UP ENSG00000257923 CUX1 cut-like homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2557] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0060090|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0045595|GO:0031228|GO:0006725|GO:0048468|GO:0006810|GO:0051130|GO:1901360|GO:0007275|GO:0003676|GO:0016358|GO:0034641|GO:0046483|GO:0051128|GO:0045597|GO:0043231|GO:0005737|GO:0030674|GO:0006139|GO:0051649|GO:0030030|GO:0048869|GO:0016021|GO:0044249|GO:0031301|GO:0031323|GO:0005794|GO:0016192|GO:0000902|GO:0005829|GO:0031175|GO:0003677|GO:0031344|GO:0010468|GO:0034645|GO:0050773|GO:0010720|GO:0048813|GO:0051252|GO:0031346|GO:0000904|GO:0030173|GO:0046907|GO:0031981|GO:0050769|GO:0005654|GO:0022604|GO:0010467|GO:0032990|GO:0007399|GO:0000139|GO:0010770|GO:0009059|GO:0030154|GO:0048858|GO:1900006|GO:0016070|GO:0005634|GO:0051960|GO:0048666|GO:0030182|GO:0000975|GO:0010975|GO:0010769|GO:0032774|GO:0043565|GO:2001141|GO:0050775|GO:0048193|GO:0003690|GO:0048814|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0010976|GO:0006351|GO:0006355|GO:0045666|GO:0006366|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0006891|GO:0045664|GO:0000976|GO:0001012|GO:0000301|GO:0000977 developmental process|cell|membrane|cellular process|metabolic process|binding|binding, bridging|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cell differentiation|intrinsic component of Golgi membrane|cellular aromatic compound metabolic process|cell development|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|dendrite development|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|protein binding, bridging|nucleobase-containing compound metabolic process|establishment of localization in cell|cell projection organization|cellular developmental process|integral component of membrane|cellular biosynthetic process|integral component of organelle membrane|regulation of cellular metabolic process|Golgi apparatus|vesicle-mediated transport|cell morphogenesis|cytosol|neuron projection development|DNA binding|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of dendrite development|positive regulation of cell development|dendrite morphogenesis|regulation of RNA metabolic process|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|integral component of Golgi membrane|intracellular transport|nuclear lumen|positive regulation of neurogenesis|nucleoplasm|regulation of cell morphogenesis|gene expression|cell part morphogenesis|nervous system development|Golgi membrane|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of dendrite development|RNA metabolic process|nucleus|regulation of nervous system development|neuron development|neuron differentiation|regulatory region DNA binding|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|positive regulation of dendrite morphogenesis|Golgi vesicle transport|double-stranded DNA binding|regulation of dendrite morphogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|intra-Golgi vesicle-mediated transport|regulation of neuron differentiation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|retrograde transport, vesicle recycling within Golgi|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 7:101815904-102283957 500 558 850 1578 1831 1736 1.57571228716943 1.59816338810641 2.41512708196463 4.45565299600583 4.73438082342694 5.12726142339619 1.86300091908016 4.77243174760965 -1.3570961792285 8.3029963319921e-10 1.85398393788551e-08 DOWN ENSG00000225762 LINC01389 long intergenic non-protein coding RNA 1389 [Source:HGNC Symbol;Acc:HGNC:50661] - - - - - - 1:47380928-47408477 4 5 3 35 30 56 0.585785200398882 0.665563012532541 0.396067871249009 4.59261628141024 3.6048473084771 7.68632579379923 0.549138694726811 5.29459646122886 -3.26927825176785 8.37851411758072e-10 1.86944813502432e-08 DOWN ENSG00000132604 TERF2 telomeric repeat binding factor 2 [Source:HGNC Symbol;Acc:HGNC:11729] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0032993|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0019222|GO:0042802|GO:0032205|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0008022|GO:0022402|GO:0051130|GO:1901360|GO:0003676|GO:0034641|GO:0030870|GO:0032204|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0032206|GO:0045786|GO:0043231|GO:0000723|GO:0005737|GO:0042592|GO:0046983|GO:0009890|GO:0019725|GO:0006139|GO:0043085|GO:0008104|GO:0044092|GO:0090344|GO:0050790|GO:0043086|GO:0048869|GO:2000773|GO:0044249|GO:0031324|GO:0031323|GO:0005794|GO:0006996|GO:0007568|GO:0051276|GO:0003677|GO:0007004|GO:0010468|GO:0034645|GO:2000772|GO:0051053|GO:1904354|GO:0045738|GO:0010833|GO:0010629|GO:0031627|GO:0090656|GO:0010628|GO:0033260|GO:0007569|GO:0031981|GO:2001020|GO:0000012|GO:0010564|GO:0051346|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0051353|GO:0034613|GO:0051341|GO:0006282|GO:0032201|GO:0051054|GO:0033043|GO:1904430|GO:0010467|GO:1904356|GO:0009059|GO:0016779|GO:0016233|GO:0005634|GO:0042803|GO:0090398|GO:1904357|GO:0006974|GO:0000783|GO:0010948|GO:0043247|GO:0010638|GO:2001252|GO:1903770|GO:0034061|GO:0033262|GO:0008156|GO:0033365|GO:0032200|GO:0006260|GO:0000781|GO:2001251|GO:0032770|GO:0043565|GO:0033044|GO:0032214|GO:0003690|GO:0070187|GO:0006275|GO:0031848|GO:0000784|GO:0051000|GO:0006278|GO:0034502|GO:0042162|GO:0003691|GO:0006261|GO:1903824|GO:0050999|GO:0003964|GO:0070198|GO:0003720 developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|protein-DNA complex|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|transferase activity|regulation of metabolic process|identical protein binding|negative regulation of telomere maintenance|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|protein C-terminus binding|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|Mre11 complex|regulation of telomere maintenance|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of telomere maintenance|negative regulation of cell cycle|intracellular membrane-bounded organelle|telomere maintenance|cytoplasm|homeostatic process|protein dimerization activity|negative regulation of biosynthetic process|cellular homeostasis|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|negative regulation of molecular function|negative regulation of cell aging|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|negative regulation of cellular senescence|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|aging|chromosome organization|DNA binding|telomere maintenance via telomerase|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of cellular senescence|negative regulation of DNA metabolic process|negative regulation of telomere capping|negative regulation of DNA repair|telomere maintenance via telomere lengthening|negative regulation of gene expression|telomeric loop formation|t-circle formation|positive regulation of gene expression|nuclear DNA replication|cell aging|nuclear lumen|regulation of response to DNA damage stimulus|single strand break repair|regulation of cell cycle process|negative regulation of hydrolase activity|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|positive regulation of oxidoreductase activity|cellular protein localization|regulation of oxidoreductase activity|regulation of DNA repair|telomere maintenance via semi-conservative replication|positive regulation of DNA metabolic process|regulation of organelle organization|negative regulation of t-circle formation|gene expression|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|nucleotidyltransferase activity|telomere capping|nucleus|protein homodimerization activity|cellular senescence|negative regulation of telomere maintenance via telomere lengthening|cellular response to DNA damage stimulus|nuclear telomere cap complex|negative regulation of cell cycle process|telomere maintenance in response to DNA damage|positive regulation of organelle organization|positive regulation of chromosome organization|negative regulation of beta-galactosidase activity|DNA polymerase activity|regulation of nuclear cell cycle DNA replication|negative regulation of DNA replication|protein localization to organelle|telomere organization|DNA replication|chromosome, telomeric region|negative regulation of chromosome organization|positive regulation of monooxygenase activity|sequence-specific DNA binding|regulation of chromosome organization|negative regulation of telomere maintenance via semi-conservative replication|double-stranded DNA binding|telosome|regulation of DNA replication|protection from non-homologous end joining at telomere|nuclear chromosome, telomeric region|positive regulation of nitric-oxide synthase activity|RNA-dependent DNA replication|protein localization to chromosome|telomeric DNA binding|double-stranded telomeric DNA binding|DNA-dependent DNA replication|negative regulation of telomere single strand break repair|regulation of nitric-oxide synthase activity|RNA-directed DNA polymerase activity|protein localization to chromosome, telomeric region|telomerase activity - - - - 16:69355561-69408571 1172 1335 1052 520 560 531 9.5007539434203 9.83539302653351 7.68883511842143 3.77686836419313 3.72466195303054 4.03417067967495 9.00832736279175 3.84523366563287 1.22818798596621 8.48159021837426e-10 1.89103356519302e-08 UP ENSG00000165092 ALDH1A1 aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0097159|GO:0016491|GO:0042562|GO:0071704|GO:0044237|GO:0042445|GO:0043227|GO:0008289|GO:0009893|GO:0030234|GO:0005622|GO:0019222|GO:0006081|GO:0044255|GO:0009410|GO:0005496|GO:0008047|GO:0044281|GO:0031982|GO:0005497|GO:0005737|GO:0016903|GO:0043085|GO:0006629|GO:0070062|GO:0006805|GO:0050790|GO:0010817|GO:0055114|GO:0005829|GO:0005096|GO:0006069|GO:0051345|GO:0006720|GO:0030695|GO:0006066|GO:0042572|GO:0016620|GO:0071466|GO:0004029|GO:0001758|GO:0043087|GO:0043547|GO:0018479|GO:0006067|GO:0016101|GO:0001523 cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|hormone binding|organic substance metabolic process|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|lipid binding|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of metabolic process|cellular aldehyde metabolic process|cellular lipid metabolic process|response to xenobiotic stimulus|steroid binding|enzyme activator activity|small molecule metabolic process|vesicle|androgen binding|cytoplasm|oxidoreductase activity, acting on the aldehyde or oxo group of donors|positive regulation of catalytic activity|lipid metabolic process|extracellular exosome|xenobiotic metabolic process|regulation of catalytic activity|regulation of hormone levels|oxidation-reduction process|cytosol|GTPase activator activity|ethanol oxidation|positive regulation of hydrolase activity|isoprenoid metabolic process|GTPase regulator activity|alcohol metabolic process|retinol metabolic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|cellular response to xenobiotic stimulus|aldehyde dehydrogenase (NAD) activity|retinal dehydrogenase activity|regulation of GTPase activity|positive regulation of GTPase activity|benzaldehyde dehydrogenase (NAD+) activity|ethanol metabolic process|diterpenoid metabolic process|retinoid metabolic process K07249 retinal dehydrogenase[1.2.1.36] hsa01100|hsa00830 Metabolic pathways - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human) 9:72900662-73080442 43 64 78 247 205 409 0.836323579637982 1.13125854634601 1.36776314518454 4.30424129477201 3.27133543472261 7.45511538727137 1.11178175705618 5.01023070558866 -2.17200342200572 8.51374159125578e-10 1.89678538406978e-08 DOWN ENSG00000187559 FOXD4L3 forkhead box D4-like 3 [Source:HGNC Symbol;Acc:HGNC:18523] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 9:68302867-68304905 81 62 17 2 4 4 2.81006217413997 1.95478799848078 0.531728057757362 0.0621685655780625 0.113848292123366 0.130035792795916 1.7655260767927 0.102017550165782 4.11320886312542 8.61836558613657e-10 1.91866283526116e-08 UP ENSG00000165684 SNAPC4 small nuclear RNA activating complex polypeptide 4 [Source:HGNC Symbol;Acc:HGNC:11137] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005667|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0044798|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0034660|GO:2001141|GO:0019185|GO:0006351|GO:0006355|GO:0006366|GO:0006383|GO:1903506|GO:0016073|GO:0042796|GO:0009301|GO:0042795 macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor complex|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|nuclear transcription factor complex|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|snRNA-activating protein complex|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter|regulation of nucleic acid-templated transcription|snRNA metabolic process|snRNA transcription from RNA polymerase III promoter|snRNA transcription|snRNA transcription from RNA polymerase II promoter - - - - 9:136375577-136398797 850 915 666 293 410 279 12.0012597736116 11.7411123106432 8.47805347461031 3.7065829722132 4.74962791034398 3.69182634992946 10.740141852955 4.04934574416221 1.40725231356818 8.84821519250497e-10 1.96836524856217e-08 UP ENSG00000118257 NRP2 neuropilin 2 [Source:HGNC Symbol;Acc:HGNC:8005] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0004872|GO:0008283|GO:0050794|GO:0040012|GO:0016049|GO:0043167|GO:0038023|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0031224|GO:0048589|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0048514|GO:0007507|GO:0008284|GO:0051272|GO:0042127|GO:0008201|GO:0006935|GO:0009888|GO:0048468|GO:0019838|GO:0001568|GO:0007275|GO:0010632|GO:0048513|GO:0043168|GO:0030900|GO:0016772|GO:2000147|GO:0007420|GO:0043169|GO:0004888|GO:0021854|GO:0007389|GO:0060322|GO:0021987|GO:0043235|GO:0006928|GO:0009887|GO:0043005|GO:0048729|GO:0050673|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0019955|GO:0021675|GO:0048532|GO:0021602|GO:0010634|GO:0021543|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0021537|GO:0005539|GO:0010033|GO:0021536|GO:0060560|GO:0050679|GO:0000902|GO:0031175|GO:0022029|GO:0048485|GO:0017154|GO:0090132|GO:0046872|GO:0007166|GO:0030424|GO:0001944|GO:0072358|GO:0007417|GO:0048483|GO:0009880|GO:0021761|GO:0000904|GO:0050919|GO:0009790|GO:0030334|GO:0001935|GO:0001667|GO:0021885|GO:0048486|GO:0001764|GO:0021979|GO:0003002|GO:0060485|GO:0061548|GO:0070848|GO:0021855|GO:0050678|GO:0016301|GO:0002116|GO:0021872|GO:0021795|GO:0006929|GO:0048864|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0010594|GO:0030154|GO:0048858|GO:0030335|GO:0021610|GO:0072359|GO:0016773|GO:1990138|GO:0010595|GO:0021545|GO:0048666|GO:0030182|GO:0007411|GO:0021953|GO:0001755|GO:0021800|GO:0048863|GO:0097491|GO:0014031|GO:1902285|GO:0061550|GO:0071363|GO:0061564|GO:0021828|GO:0001936|GO:1904835|GO:0097490|GO:0007167|GO:0021649|GO:0021954|GO:1901166|GO:0061549|GO:0021562|GO:0010631|GO:1990791|GO:0001938|GO:0004672|GO:0048762|GO:0021879|GO:0071526|GO:0022008|GO:0048667|GO:0004714|GO:0021612|GO:0048812|GO:0035282|GO:0048675|GO:0014033|GO:0014032|GO:0061551|GO:0005021|GO:0097374|GO:0007409|GO:0048699|GO:0035924|GO:0004713|GO:0021884|GO:1903375|GO:0048846|GO:0043542|GO:0007169|GO:0036486|GO:0048010|GO:0038084 locomotion|developmental process|growth|macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|receptor activity|cell proliferation|regulation of cellular process|regulation of locomotion|cell growth|ion binding|signaling receptor activity|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|intrinsic component of membrane|developmental growth|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|heparin binding|chemotaxis|tissue development|cell development|growth factor binding|blood vessel development|multicellular organism development|regulation of epithelial cell migration|animal organ development|anion binding|forebrain development|transferase activity, transferring phosphorus-containing groups|positive regulation of cell motility|brain development|cation binding|transmembrane signaling receptor activity|hypothalamus development|pattern specification process|head development|cerebral cortex development|receptor complex|movement of cell or subcellular component|organ morphogenesis|neuron projection|tissue morphogenesis|epithelial cell proliferation|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|cytokine binding|nerve development|anatomical structure arrangement|cranial nerve morphogenesis|positive regulation of epithelial cell migration|pallium development|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|telencephalon development|glycosaminoglycan binding|response to organic substance|diencephalon development|developmental growth involved in morphogenesis|positive regulation of epithelial cell proliferation|cell morphogenesis|neuron projection development|telencephalon cell migration|sympathetic nervous system development|semaphorin receptor activity|epithelium migration|metal ion binding|cell surface receptor signaling pathway|axon|vasculature development|cardiovascular system development|central nervous system development|autonomic nervous system development|embryonic pattern specification|limbic system development|cell morphogenesis involved in differentiation|negative chemotaxis|embryo development|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|forebrain cell migration|parasympathetic nervous system development|neuron migration|hypothalamus cell differentiation|regionalization|mesenchyme development|ganglion development|response to growth factor|hypothalamus cell migration|regulation of epithelial cell proliferation|kinase activity|semaphorin receptor complex|forebrain generation of neurons|cerebral cortex cell migration|substrate-dependent cell migration|stem cell development|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of endothelial cell migration|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|facial nerve morphogenesis|circulatory system development|phosphotransferase activity, alcohol group as acceptor|neuron projection extension|positive regulation of endothelial cell migration|cranial nerve development|neuron development|neuron differentiation|axon guidance|central nervous system neuron differentiation|neural crest cell migration|cerebral cortex tangential migration|stem cell differentiation|sympathetic neuron projection guidance|mesenchymal cell development|semaphorin-plexin signaling pathway involved in neuron projection guidance|cranial ganglion development|cellular response to growth factor stimulus|axon development|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|regulation of endothelial cell proliferation|dorsal root ganglion morphogenesis|sympathetic neuron projection extension|enzyme linked receptor protein signaling pathway|vestibulocochlear nerve structural organization|central nervous system neuron development|neural crest cell migration involved in autonomic nervous system development|sympathetic ganglion development|vestibulocochlear nerve development|epithelial cell migration|dorsal root ganglion development|positive regulation of endothelial cell proliferation|protein kinase activity|mesenchymal cell differentiation|forebrain neuron differentiation|semaphorin-plexin signaling pathway|neurogenesis|cell morphogenesis involved in neuron differentiation|transmembrane receptor protein tyrosine kinase activity|facial nerve structural organization|neuron projection morphogenesis|segmentation|axon extension|neural crest cell differentiation|neural crest cell development|trigeminal ganglion development|vascular endothelial growth factor-activated receptor activity|sensory neuron axon guidance|axonogenesis|generation of neurons|cellular response to vascular endothelial growth factor stimulus|protein tyrosine kinase activity|forebrain neuron development|facioacoustic ganglion development|axon extension involved in axon guidance|endothelial cell migration|transmembrane receptor protein tyrosine kinase signaling pathway|ventral trunk neural crest cell migration|vascular endothelial growth factor receptor signaling pathway|vascular endothelial growth factor signaling pathway - - - - 2:205681990-205798133 130 155 277 601 733 536 0.457842208063472 0.496119604028561 0.879566170713983 1.89646890681408 2.11809706114351 1.76916116891871 0.611175994268672 1.92790904562543 -1.65737720657837 9.1660981102213e-10 2.03756286658635e-08 DOWN ENSG00000133639 BTG1 B-cell translocation gene 1, anti-proliferative [Source:HGNC Symbol;Acc:HGNC:1130] GO:0040011|GO:0032502|GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0048870|GO:0000989|GO:0045926|GO:0009653|GO:0016043|GO:0043227|GO:0040008|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0042127|GO:0045595|GO:0003712|GO:0006725|GO:0009888|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0034641|GO:0046483|GO:0051128|GO:0010942|GO:0061061|GO:0045597|GO:0043231|GO:0019899|GO:0030308|GO:0005737|GO:0006928|GO:0006139|GO:0001525|GO:0016477|GO:0008219|GO:0008285|GO:0048869|GO:0044249|GO:0001558|GO:0031323|GO:0051149|GO:0010468|GO:0034645|GO:0001944|GO:0072358|GO:0042692|GO:0051252|GO:0051147|GO:0030856|GO:0045766|GO:0045765|GO:0030858|GO:0019900|GO:0012501|GO:0060429|GO:1901342|GO:0010467|GO:0009059|GO:0030154|GO:0043068|GO:0016070|GO:0072359|GO:0005634|GO:0043067|GO:0003158|GO:0045445|GO:0043065|GO:0030855|GO:0045663|GO:0032774|GO:2001141|GO:0045661|GO:0042981|GO:0045603|GO:0045601|GO:0006351|GO:0006915|GO:0006355|GO:0045446|GO:0044346|GO:2000269|GO:1903506|GO:2000271 locomotion|developmental process|growth|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|cell motility|transcription factor activity, transcription factor binding|negative regulation of growth|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|regulation of growth|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cell proliferation|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell death|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|negative regulation of cell growth|cytoplasm|movement of cell or subcellular component|nucleobase-containing compound metabolic process|angiogenesis|cell migration|cell death|negative regulation of cell proliferation|cellular developmental process|cellular biosynthetic process|regulation of cell growth|regulation of cellular metabolic process|positive regulation of muscle cell differentiation|regulation of gene expression|cellular macromolecule biosynthetic process|vasculature development|cardiovascular system development|muscle cell differentiation|regulation of RNA metabolic process|regulation of muscle cell differentiation|regulation of epithelial cell differentiation|positive regulation of angiogenesis|regulation of angiogenesis|positive regulation of epithelial cell differentiation|kinase binding|programmed cell death|epithelium development|regulation of vasculature development|gene expression|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|RNA metabolic process|circulatory system development|nucleus|regulation of programmed cell death|endothelium development|myoblast differentiation|positive regulation of apoptotic process|epithelial cell differentiation|positive regulation of myoblast differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of myoblast differentiation|regulation of apoptotic process|positive regulation of endothelial cell differentiation|regulation of endothelial cell differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|endothelial cell differentiation|fibroblast apoptotic process|regulation of fibroblast apoptotic process|regulation of nucleic acid-templated transcription|positive regulation of fibroblast apoptotic process K14443 protein Tob/BTG[-] hsa03018 RNA degradation - Homo sapiens (human) 12:92140278-92145897 2025 2021 3017 1086 1175 1044 27.631582599421 25.0626523196545 37.1167843599018 13.2772564960241 13.1548659119801 13.3508857512803 29.9370064263258 13.2610027197615 1.1747400974551 9.27742633574592e-10 2.06077593621547e-08 UP ENSG00000125845 BMP2 bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0016491|GO:0050794|GO:0031128|GO:0040012|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0009986|GO:0044237|GO:0042445|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0030234|GO:0050793|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0039706|GO:0008284|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:0003179|GO:0016337|GO:0045595|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0010718|GO:0035295|GO:0051130|GO:1901360|GO:0048839|GO:0010941|GO:0098797|GO:0007275|GO:0033687|GO:0019208|GO:0045596|GO:0048513|GO:0072028|GO:0005102|GO:0034641|GO:0008047|GO:0043062|GO:0044281|GO:0006952|GO:0030155|GO:0030900|GO:0061036|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0032350|GO:0007420|GO:0016614|GO:0010942|GO:0070169|GO:0098609|GO:0051098|GO:0061061|GO:0005887|GO:0045786|GO:0045597|GO:0046332|GO:0048635|GO:0072111|GO:0007389|GO:0001763|GO:0007267|GO:0003170|GO:0060322|GO:0007423|GO:0043235|GO:0006928|GO:0009887|GO:0009966|GO:0048729|GO:0046983|GO:0072006|GO:0048568|GO:0050673|GO:0009890|GO:1901862|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0007162|GO:0007154|GO:0045778|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0008207|GO:0030278|GO:0009968|GO:0031647|GO:0001503|GO:0042180|GO:0042446|GO:0003308|GO:0008219|GO:0048645|GO:0060348|GO:0008285|GO:0001666|GO:0042482|GO:0050790|GO:0045833|GO:0010817|GO:0001759|GO:0048869|GO:0016021|GO:2000145|GO:0021537|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0021536|GO:0048732|GO:0021984|GO:0072089|GO:0055114|GO:0043931|GO:0000165|GO:0050679|GO:0030501|GO:1902533|GO:0032268|GO:0030111|GO:0000902|GO:0060039|GO:0098742|GO:0010468|GO:0005126|GO:0071773|GO:0034645|GO:0003156|GO:0030178|GO:0033688|GO:0051216|GO:0032353|GO:0007166|GO:2000736|GO:0002009|GO:0043412|GO:0072164|GO:0072358|GO:0007417|GO:0051345|GO:0001655|GO:0010629|GO:0043583|GO:0010720|GO:0042692|GO:0043569|GO:0046982|GO:1901522|GO:0051252|GO:0006066|GO:0035050|GO:0035051|GO:0048738|GO:0010717|GO:0070977|GO:0003007|GO:0031943|GO:0010463|GO:0048754|GO:0045667|GO:0005125|GO:0061138|GO:0031214|GO:0000904|GO:0009790|GO:0010628|GO:0030334|GO:0051055|GO:0051147|GO:0003181|GO:0001935|GO:0051347|GO:0009100|GO:0036211|GO:0060537|GO:0021871|GO:2000027|GO:0072001|GO:0006954|GO:0001649|GO:0045843|GO:0021983|GO:0006700|GO:0060914|GO:0022408|GO:0033690|GO:0003002|GO:0022407|GO:0043567|GO:0033612|GO:0016616|GO:0060485|GO:0035270|GO:0060128|GO:0070724|GO:0031098|GO:0050769|GO:0045600|GO:0021978|GO:0051099|GO:0051247|GO:0045939|GO:0070848|GO:0022604|GO:0010092|GO:0050678|GO:0003171|GO:0045669|GO:0061326|GO:0010565|GO:0008202|GO:0032270|GO:0060993|GO:0012501|GO:0003197|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0072073|GO:0042476|GO:0044267|GO:0051174|GO:0019211|GO:0048864|GO:0010467|GO:0008610|GO:0007399|GO:0060562|GO:0060129|GO:0019216|GO:0071310|GO:0060395|GO:0030198|GO:0031648|GO:0045598|GO:0046890|GO:0060415|GO:0031328|GO:0051246|GO:0030177|GO:0010770|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0001823|GO:0030335|GO:0061035|GO:0043068|GO:0007517|GO:1902531|GO:0061312|GO:0016070|GO:0008083|GO:0072359|GO:0010557|GO:0030282|GO:0051148|GO:0043067|GO:0051960|GO:0045165|GO:2000738|GO:0048644|GO:0030500|GO:0006705|GO:0046885|GO:0034650|GO:0016202|GO:0043393|GO:0030182|GO:0004745|GO:0016055|GO:0070304|GO:0055024|GO:0051153|GO:0045893|GO:0048863|GO:0016311|GO:0045444|GO:0003130|GO:0060317|GO:0060393|GO:0009792|GO:0031401|GO:0042481|GO:0035054|GO:0090090|GO:0010566|GO:0010001|GO:0051154|GO:2000065|GO:0043065|GO:0001657|GO:0030855|GO:0043408|GO:0010769|GO:0060828|GO:0045892|GO:0010922|GO:0002062|GO:0032774|GO:0019218|GO:2001141|GO:0072078|GO:0014031|GO:0071363|GO:0072163|GO:0016310|GO:0001658|GO:0035630|GO:1902679|GO:0070371|GO:0071407|GO:0001936|GO:0006694|GO:0030509|GO:0061333|GO:0007167|GO:0010862|GO:0031947|GO:0032092|GO:0043410|GO:0050810|GO:0014015|GO:0072080|GO:0051146|GO:0032872|GO:0042981|GO:0009952|GO:0010894|GO:0006029|GO:0001938|GO:0042475|GO:0060804|GO:0048762|GO:0005160|GO:0060850|GO:0055008|GO:0007219|GO:0014706|GO:0022008|GO:0055007|GO:0006464|GO:0034651|GO:2000826|GO:0050767|GO:0001837|GO:0051403|GO:0051042|GO:0072138|GO:0043549|GO:0032348|GO:0048708|GO:0006351|GO:0003203|GO:0016338|GO:0006915|GO:0006355|GO:0032342|GO:0010921|GO:0033674|GO:0008211|GO:0045666|GO:0055026|GO:0006470|GO:0035304|GO:0048710|GO:0045944|GO:0006366|GO:0045859|GO:1903507|GO:0045860|GO:0043406|GO:1900744|GO:0070700|GO:0006357|GO:0038066|GO:0006468|GO:0048699|GO:0014013|GO:0006704|GO:0035307|GO:1903506|GO:0045685|GO:0060070|GO:0043405|GO:0048711|GO:0042325|GO:0070374|GO:0001932|GO:0060675|GO:0045687|GO:0042063|GO:0043009|GO:0042487|GO:0032874|GO:0001934|GO:0035306|GO:0007178|GO:2000726|GO:0000122|GO:0070372|GO:0045664|GO:0042327|GO:0035303|GO:0007169|GO:0002067|GO:0048009|GO:0000187|GO:1900745|GO:0071902|GO:0060563|GO:0060389|GO:0071900|GO:0001701|GO:0032147|GO:0061101 locomotion|developmental process|growth|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|oxidoreductase activity|regulation of cellular process|developmental induction|regulation of locomotion|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cell surface|cellular metabolic process|hormone metabolic process|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|enzyme regulator activity|regulation of developmental process|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|co-receptor binding|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|heart valve morphogenesis|single organismal cell-cell adhesion|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|positive regulation of epithelial to mesenchymal transition|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|inner ear development|regulation of cell death|plasma membrane protein complex|multicellular organism development|osteoblast proliferation|phosphatase regulator activity|negative regulation of cell differentiation|animal organ development|nephron morphogenesis|receptor binding|cellular nitrogen compound metabolic process|enzyme activator activity|extracellular structure organization|small molecule metabolic process|defense response|regulation of cell adhesion|forebrain development|positive regulation of cartilage development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|regulation of hormone metabolic process|brain development|oxidoreductase activity, acting on CH-OH group of donors|positive regulation of cell death|positive regulation of biomineral tissue development|cell-cell adhesion|regulation of binding|muscle structure development|integral component of plasma membrane|negative regulation of cell cycle|positive regulation of cell differentiation|SMAD binding|negative regulation of muscle organ development|cell proliferation involved in kidney development|pattern specification process|morphogenesis of a branching structure|cell-cell signaling|heart valve development|head development|sensory organ development|receptor complex|movement of cell or subcellular component|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|nephron development|embryonic organ development|epithelial cell proliferation|negative regulation of biosynthetic process|negative regulation of muscle tissue development|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|negative regulation of cell adhesion|cell communication|positive regulation of ossification|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|C21-steroid hormone metabolic process|regulation of ossification|negative regulation of signal transduction|regulation of protein stability|ossification|cellular ketone metabolic process|hormone biosynthetic process|negative regulation of Wnt signaling pathway involved in heart development|cell death|organ formation|bone development|negative regulation of cell proliferation|response to hypoxia|positive regulation of odontogenesis|regulation of catalytic activity|negative regulation of lipid metabolic process|regulation of hormone levels|organ induction|cellular developmental process|integral component of membrane|regulation of cell motility|telencephalon development|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|diencephalon development|gland development|adenohypophysis development|stem cell proliferation|oxidation-reduction process|ossification involved in bone maturation|MAPK cascade|positive regulation of epithelial cell proliferation|positive regulation of bone mineralization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|pericardium development|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of gene expression|cytokine receptor binding|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|regulation of organ formation|negative regulation of Wnt signaling pathway|regulation of osteoblast proliferation|cartilage development|negative regulation of hormone biosynthetic process|cell surface receptor signaling pathway|regulation of stem cell differentiation|morphogenesis of an epithelium|macromolecule modification|mesonephric tubule development|cardiovascular system development|central nervous system development|positive regulation of hydrolase activity|urogenital system development|negative regulation of gene expression|ear development|positive regulation of cell development|muscle cell differentiation|negative regulation of insulin-like growth factor receptor signaling pathway|protein heterodimerization activity|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|regulation of RNA metabolic process|alcohol metabolic process|embryonic heart tube development|cardiocyte differentiation|cardiac muscle tissue development|regulation of epithelial to mesenchymal transition|bone maturation|heart morphogenesis|regulation of glucocorticoid metabolic process|mesenchymal cell proliferation|branching morphogenesis of an epithelial tube|regulation of osteoblast differentiation|cytokine activity|morphogenesis of a branching epithelium|biomineral tissue development|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|regulation of cell migration|negative regulation of lipid biosynthetic process|regulation of muscle cell differentiation|atrioventricular valve morphogenesis|endothelial cell proliferation|positive regulation of transferase activity|glycoprotein metabolic process|protein modification process|muscle tissue development|forebrain regionalization|regulation of organ morphogenesis|renal system development|inflammatory response|osteoblast differentiation|negative regulation of striated muscle tissue development|pituitary gland development|C21-steroid hormone biosynthetic process|heart formation|negative regulation of cell-cell adhesion|positive regulation of osteoblast proliferation|regionalization|regulation of cell-cell adhesion|regulation of insulin-like growth factor receptor signaling pathway|receptor serine/threonine kinase binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|mesenchyme development|endocrine system development|corticotropin hormone secreting cell differentiation|BMP receptor complex|stress-activated protein kinase signaling cascade|positive regulation of neurogenesis|positive regulation of fat cell differentiation|telencephalon regionalization|positive regulation of binding|positive regulation of protein metabolic process|negative regulation of steroid metabolic process|response to growth factor|regulation of cell morphogenesis|specification of organ identity|regulation of epithelial cell proliferation|atrioventricular valve development|positive regulation of osteoblast differentiation|renal tubule development|regulation of cellular ketone metabolic process|steroid metabolic process|positive regulation of cellular protein metabolic process|kidney morphogenesis|programmed cell death|endocardial cushion development|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|kidney epithelium development|odontogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|phosphatase activator activity|stem cell development|gene expression|lipid biosynthetic process|nervous system development|epithelial tube morphogenesis|thyroid-stimulating hormone-secreting cell differentiation|regulation of lipid metabolic process|cellular response to organic substance|SMAD protein signal transduction|extracellular matrix organization|protein destabilization|regulation of fat cell differentiation|regulation of lipid biosynthetic process|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|mesonephros development|positive regulation of cell migration|regulation of cartilage development|positive regulation of programmed cell death|muscle organ development|regulation of intracellular signal transduction|BMP signaling pathway involved in heart development|RNA metabolic process|growth factor activity|circulatory system development|positive regulation of macromolecule biosynthetic process|bone mineralization|negative regulation of muscle cell differentiation|regulation of programmed cell death|regulation of nervous system development|cell fate commitment|positive regulation of stem cell differentiation|muscle organ morphogenesis|regulation of bone mineralization|mineralocorticoid biosynthetic process|regulation of hormone biosynthetic process|cortisol metabolic process|regulation of striated muscle tissue development|regulation of protein binding|neuron differentiation|retinol dehydrogenase activity|Wnt signaling pathway|positive regulation of stress-activated protein kinase signaling cascade|regulation of cardiac muscle tissue development|regulation of striated muscle cell differentiation|positive regulation of transcription, DNA-templated|stem cell differentiation|dephosphorylation|fat cell differentiation|BMP signaling pathway involved in heart induction|cardiac epithelial to mesenchymal transition|regulation of pathway-restricted SMAD protein phosphorylation|embryo development ending in birth or egg hatching|positive regulation of protein modification process|regulation of odontogenesis|embryonic heart tube anterior/posterior pattern specification|negative regulation of canonical Wnt signaling pathway|regulation of ketone biosynthetic process|glial cell differentiation|negative regulation of striated muscle cell differentiation|negative regulation of cortisol biosynthetic process|positive regulation of apoptotic process|ureteric bud development|epithelial cell differentiation|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of phosphatase activity|chondrocyte differentiation|RNA biosynthetic process|regulation of steroid metabolic process|regulation of RNA biosynthetic process|nephron tubule morphogenesis|mesenchymal cell development|cellular response to growth factor stimulus|mesonephric epithelium development|phosphorylation|branching involved in ureteric bud morphogenesis|bone mineralization involved in bone maturation|negative regulation of RNA biosynthetic process|ERK1 and ERK2 cascade|cellular response to organic cyclic compound|regulation of endothelial cell proliferation|steroid biosynthetic process|BMP signaling pathway|renal tubule morphogenesis|enzyme linked receptor protein signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of glucocorticoid biosynthetic process|positive regulation of protein binding|positive regulation of MAPK cascade|regulation of steroid biosynthetic process|positive regulation of gliogenesis|nephron tubule development|striated muscle cell differentiation|regulation of stress-activated MAPK cascade|regulation of apoptotic process|anterior/posterior pattern specification|negative regulation of steroid biosynthetic process|proteoglycan metabolic process|positive regulation of endothelial cell proliferation|odontogenesis of dentin-containing tooth|positive regulation of Wnt signaling pathway by BMP signaling pathway|mesenchymal cell differentiation|transforming growth factor beta receptor binding|regulation of transcription involved in cell fate commitment|cardiac muscle tissue morphogenesis|Notch signaling pathway|striated muscle tissue development|neurogenesis|cardiac muscle cell differentiation|cellular protein modification process|cortisol biosynthetic process|regulation of heart morphogenesis|regulation of neurogenesis|epithelial to mesenchymal transition|stress-activated MAPK cascade|negative regulation of calcium-independent cell-cell adhesion|mesenchymal cell proliferation involved in ureteric bud development|regulation of kinase activity|negative regulation of aldosterone biosynthetic process|astrocyte differentiation|transcription, DNA-templated|endocardial cushion morphogenesis|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|apoptotic process|regulation of transcription, DNA-templated|aldosterone biosynthetic process|regulation of phosphatase activity|positive regulation of kinase activity|glucocorticoid metabolic process|positive regulation of neuron differentiation|negative regulation of cardiac muscle tissue development|protein dephosphorylation|regulation of protein dephosphorylation|regulation of astrocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of p38MAPK cascade|BMP receptor binding|regulation of transcription from RNA polymerase II promoter|p38MAPK cascade|protein phosphorylation|generation of neurons|regulation of gliogenesis|glucocorticoid biosynthetic process|positive regulation of protein dephosphorylation|regulation of nucleic acid-templated transcription|regulation of glial cell differentiation|canonical Wnt signaling pathway|regulation of MAP kinase activity|positive regulation of astrocyte differentiation|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|ureteric bud morphogenesis|positive regulation of glial cell differentiation|gliogenesis|chordate embryonic development|regulation of odontogenesis of dentin-containing tooth|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|positive regulation of dephosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of cardiac muscle cell differentiation|negative regulation of transcription from RNA polymerase II promoter|regulation of ERK1 and ERK2 cascade|regulation of neuron differentiation|positive regulation of phosphorylation|regulation of dephosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|glandular epithelial cell differentiation|insulin-like growth factor receptor signaling pathway|activation of MAPK activity|positive regulation of p38MAPK cascade|positive regulation of protein serine/threonine kinase activity|neuroepithelial cell differentiation|pathway-restricted SMAD protein phosphorylation|regulation of protein serine/threonine kinase activity|in utero embryonic development|activation of protein kinase activity|neuroendocrine cell differentiation K04662 bone morphogenetic protein 2/4[-] hsa05200|hsa04060|hsa04390|hsa04550|hsa04350|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 20:6767664-6780280 63 47 100 16 16 12 1.23755800584714 0.839081816821476 1.77108350540513 0.28159664634749 0.257874143823134 0.220910708492924 1.28257444269125 0.253460499554516 2.3392097309575 9.28824944086889e-10 2.06164608778959e-08 UP ENSG00000099812 MISP mitotic spindle positioning [Source:HGNC Symbol;Acc:HGNC:27000] GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0030055|GO:0043229|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0007049|GO:0022402|GO:0005938|GO:0005924|GO:0005912|GO:0043231|GO:0005737|GO:0008092|GO:0051301|GO:0006996|GO:1903047|GO:0003779|GO:0000278|GO:0007067|GO:0005856|GO:0005925 cell|membrane|cellular process|cell junction|binding|cell-substrate junction|intracellular organelle|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|cell cycle|cell cycle process|cell cortex|cell-substrate adherens junction|adherens junction|intracellular membrane-bounded organelle|cytoplasm|cytoskeletal protein binding|cell division|organelle organization|mitotic cell cycle process|actin binding|mitotic cell cycle|mitotic nuclear division|cytoskeleton|focal adhesion - - - - 19:751126-764318 4358 4400 4469 2112 2389 1659 84.9231899980896 77.9241030974656 78.5170079008883 36.874895986444 38.1964698924564 30.2980366018493 80.4547669988145 35.1231341602499 1.19575631678063 9.36532454816072e-10 2.07720950268046e-08 UP ENSG00000151376 ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial [Source:HGNC Symbol;Acc:HGNC:6985] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0005622|GO:0016830|GO:0006082|GO:0015980|GO:0044281|GO:0016614|GO:0043231|GO:0043169|GO:0005737|GO:0072592|GO:0050662|GO:0000166|GO:0006091|GO:0055114|GO:0046872|GO:0016616|GO:0016831|GO:0005759|GO:0005739|GO:0045333|GO:0016615|GO:0051287|GO:0009060|GO:0004471|GO:0008948|GO:0004470|GO:0019752|GO:0004473|GO:0043648|GO:0032787|GO:0006090|GO:0006108 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|intracellular|carbon-carbon lyase activity|organic acid metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxygen metabolic process|coenzyme binding|nucleotide binding|generation of precursor metabolites and energy|oxidation-reduction process|metal ion binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|carboxy-lyase activity|mitochondrial matrix|mitochondrion|cellular respiration|malate dehydrogenase activity|NAD binding|aerobic respiration|malate dehydrogenase (decarboxylating) (NAD+) activity|oxaloacetate decarboxylase activity|malic enzyme activity|carboxylic acid metabolic process|malate dehydrogenase (decarboxylating) (NADP+) activity|dicarboxylic acid metabolic process|monocarboxylic acid metabolic process|pyruvate metabolic process|malate metabolic process K00029 malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+)[1.1.1.40] hsa01100|hsa01200|hsa00620 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Pyruvate metabolism - Homo sapiens (human) 11:86441108-86672636 106 149 165 427 432 399 1.15019005633532 1.46937236300648 1.61421663013743 4.15135670333544 3.84606592200317 4.05757427411849 1.41125968315974 4.01833229981903 -1.50961339416454 9.44494147561164e-10 2.09331316119458e-08 DOWN ENSG00000130508 PXDN peroxidasin [Source:HGNC Symbol;Acc:HGNC:14966] GO:0016209|GO:0031012|GO:0002376|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0097159|GO:0005201|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0005578|GO:0006950|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0023057|GO:0004601|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0098869|GO:0019838|GO:0005102|GO:0043062|GO:0031982|GO:0060761|GO:0043231|GO:0043169|GO:0005737|GO:0072593|GO:0009966|GO:0042744|GO:0006979|GO:0010646|GO:0007154|GO:0007165|GO:0005783|GO:0009968|GO:0070062|GO:0019955|GO:0010033|GO:0016684|GO:0030547|GO:0055114|GO:0009636|GO:0005126|GO:0046872|GO:0042743|GO:0007166|GO:0020037|GO:0001959|GO:0034097|GO:0071310|GO:0030198|GO:0001960|GO:0048019|GO:0019966|GO:0019221|GO:0071345|GO:0005152 antioxidant activity|extracellular matrix|immune system process|structural molecule activity|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|extracellular matrix structural constituent|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|response to stress|catabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of signaling|peroxidase activity|extracellular space|intracellular|protein binding|endomembrane system|cellular oxidant detoxification|growth factor binding|receptor binding|extracellular structure organization|vesicle|negative regulation of response to cytokine stimulus|intracellular membrane-bounded organelle|cation binding|cytoplasm|reactive oxygen species metabolic process|regulation of signal transduction|hydrogen peroxide catabolic process|response to oxidative stress|regulation of cell communication|cell communication|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|extracellular exosome|cytokine binding|response to organic substance|oxidoreductase activity, acting on peroxide as acceptor|receptor inhibitor activity|oxidation-reduction process|response to toxic substance|cytokine receptor binding|metal ion binding|hydrogen peroxide metabolic process|cell surface receptor signaling pathway|heme binding|regulation of cytokine-mediated signaling pathway|response to cytokine|cellular response to organic substance|extracellular matrix organization|negative regulation of cytokine-mediated signaling pathway|receptor antagonist activity|interleukin-1 binding|cytokine-mediated signaling pathway|cellular response to cytokine stimulus|interleukin-1 receptor antagonist activity - - - - 2:1631887-1744852 717 879 1235 2362 2649 2423 3.12921501095263 3.48646531351652 4.85956678129024 9.23621103890622 9.48563149620359 9.91057063430564 3.82508236858646 9.54413772313848 -1.31912404660216 9.51262098765676e-10 2.10674916146517e-08 DOWN ENSG00000133816 MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24693] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0048037|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0007507|GO:0035239|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0007389|GO:0016705|GO:0009887|GO:0048729|GO:0048598|GO:0048568|GO:0006139|GO:0004497|GO:0008092|GO:0050662|GO:0000166|GO:0019417|GO:0030029|GO:0044249|GO:0031323|GO:0006996|GO:0006790|GO:0043914|GO:0055114|GO:0003143|GO:0010468|GO:0034645|GO:0046872|GO:0002009|GO:0007010|GO:0072358|GO:0050660|GO:0051252|GO:0035050|GO:0016709|GO:0003779|GO:0003007|GO:0009790|GO:0010628|GO:0061371|GO:0030036|GO:0060429|GO:0010467|GO:0048562|GO:0060562|GO:0031328|GO:0009059|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0043241|GO:0045893|GO:0032774|GO:2001141|GO:0001947|GO:0071949|GO:0009855|GO:0046914|GO:0007015|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0043624|GO:0007368|GO:1903506|GO:0008270|GO:0008154|GO:0010735|GO:0030042|GO:0051261 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cofactor binding|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|heart development|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|pattern specification process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|organ morphogenesis|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|nucleobase-containing compound metabolic process|monooxygenase activity|cytoskeletal protein binding|coenzyme binding|nucleotide binding|sulfur oxidation|actin filament-based process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|sulfur compound metabolic process|NADPH:sulfur oxidoreductase activity|oxidation-reduction process|embryonic heart tube morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|morphogenesis of an epithelium|cytoskeleton organization|cardiovascular system development|flavin adenine dinucleotide binding|regulation of RNA metabolic process|embryonic heart tube development|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|actin binding|heart morphogenesis|embryo development|positive regulation of gene expression|determination of heart left/right asymmetry|actin cytoskeleton organization|epithelium development|gene expression|embryonic organ morphogenesis|epithelial tube morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|protein complex disassembly|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|heart looping|FAD binding|determination of bilateral symmetry|transition metal ion binding|actin filament organization|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|cellular protein complex disassembly|determination of left/right symmetry|regulation of nucleic acid-templated transcription|zinc ion binding|actin polymerization or depolymerization|positive regulation of transcription via serum response element binding|actin filament depolymerization|protein depolymerization - - - - 11:12094008-12263789 28 66 141 395 463 458 0.0653061864777605 0.139902464297632 0.296507244536353 0.825460669474977 0.886034361044861 1.00114347426525 0.167238631770582 0.904212834928363 -2.43475425084145 9.53932683859201e-10 2.11109757923889e-08 DOWN ENSG00000137845 ADAM10 ADAM metallopeptidase domain 10 [Source:HGNC Symbol;Acc:HGNC:188] GO:0040011|GO:0032502|GO:0040007|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0030055|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0060076|GO:0040012|GO:0043229|GO:0016049|GO:0048520|GO:0071704|GO:0050900|GO:0009056|GO:0043167|GO:0009986|GO:0044237|GO:0050795|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0016787|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0042802|GO:0008284|GO:0051272|GO:0042127|GO:0006935|GO:0002685|GO:0048468|GO:0007275|GO:0005102|GO:0030307|GO:0005924|GO:0043062|GO:0030155|GO:0005912|GO:0031982|GO:0051128|GO:2000147|GO:0043231|GO:0043169|GO:0008233|GO:0019899|GO:0005737|GO:0007267|GO:0050920|GO:0006928|GO:0032403|GO:0002687|GO:0001775|GO:0046983|GO:0050839|GO:0014069|GO:0019904|GO:0044236|GO:0007162|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0070062|GO:0030595|GO:0030030|GO:0072676|GO:0048869|GO:0016021|GO:2000145|GO:0097197|GO:0019538|GO:0010033|GO:0001558|GO:0005794|GO:0050921|GO:0000902|GO:0031175|GO:0030574|GO:0005798|GO:0044259|GO:0042117|GO:0005802|GO:0002688|GO:0046872|GO:0007166|GO:0043412|GO:0022617|GO:0034097|GO:0031410|GO:0002690|GO:0017124|GO:0072678|GO:0051604|GO:0000904|GO:0009790|GO:0030334|GO:0016023|GO:0036211|GO:0005178|GO:0060326|GO:0048471|GO:0006508|GO:0031988|GO:0019900|GO:0006796|GO:0044267|GO:0010467|GO:0032990|GO:0007399|GO:0097485|GO:0030198|GO:2000401|GO:0030154|GO:0048858|GO:0030335|GO:0097038|GO:0005634|GO:0042803|GO:0005925|GO:0048247|GO:0048666|GO:0030182|GO:0008237|GO:0007411|GO:0009792|GO:0016485|GO:0007220|GO:0010820|GO:2000404|GO:0016310|GO:0007229|GO:2000406|GO:0010818|GO:0033619|GO:0061564|GO:0007167|GO:0004175|GO:0046914|GO:0034612|GO:0007219|GO:0019901|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0032963|GO:0006509|GO:0007409|GO:0006468|GO:0048699|GO:0043009|GO:0010819|GO:0008270|GO:0004222|GO:0007169|GO:0051089|GO:0048013|GO:0051088|GO:0001701|GO:0038127|GO:0007173 locomotion|developmental process|growth|immune system process|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|excitatory synapse|regulation of locomotion|intracellular organelle|cell growth|positive regulation of behavior|organic substance metabolic process|leukocyte migration|catabolic process|ion binding|cell surface|cellular metabolic process|regulation of behavior|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|hydrolase activity|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|anatomical structure development|identical protein binding|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|chemotaxis|regulation of leukocyte migration|cell development|multicellular organism development|receptor binding|positive regulation of cell growth|cell-substrate adherens junction|extracellular structure organization|regulation of cell adhesion|adherens junction|vesicle|regulation of cellular component organization|positive regulation of cell motility|intracellular membrane-bounded organelle|cation binding|peptidase activity|enzyme binding|cytoplasm|cell-cell signaling|regulation of chemotaxis|movement of cell or subcellular component|protein complex binding|positive regulation of leukocyte migration|cell activation|protein dimerization activity|cell adhesion molecule binding|postsynaptic density|protein domain specific binding|multicellular organism metabolic process|negative regulation of cell adhesion|cell communication|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|extracellular exosome|leukocyte chemotaxis|cell projection organization|lymphocyte migration|cellular developmental process|integral component of membrane|regulation of cell motility|tetraspanin-enriched microdomain|protein metabolic process|response to organic substance|regulation of cell growth|Golgi apparatus|positive regulation of chemotaxis|cell morphogenesis|neuron projection development|collagen catabolic process|Golgi-associated vesicle|multicellular organismal macromolecule metabolic process|monocyte activation|trans-Golgi network|regulation of leukocyte chemotaxis|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|extracellular matrix disassembly|response to cytokine|cytoplasmic vesicle|positive regulation of leukocyte chemotaxis|SH3 domain binding|T cell migration|protein maturation|cell morphogenesis involved in differentiation|embryo development|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|protein modification process|integrin binding|cell chemotaxis|perinuclear region of cytoplasm|proteolysis|membrane-bounded vesicle|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|cell part morphogenesis|nervous system development|neuron projection guidance|extracellular matrix organization|regulation of lymphocyte migration|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|perinuclear endoplasmic reticulum|nucleus|protein homodimerization activity|focal adhesion|lymphocyte chemotaxis|neuron development|neuron differentiation|metallopeptidase activity|axon guidance|embryo development ending in birth or egg hatching|protein processing|Notch receptor processing|positive regulation of T cell chemotaxis|regulation of T cell migration|phosphorylation|integrin-mediated signaling pathway|positive regulation of T cell migration|T cell chemotaxis|membrane protein proteolysis|axon development|enzyme linked receptor protein signaling pathway|endopeptidase activity|transition metal ion binding|response to tumor necrosis factor|Notch signaling pathway|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|collagen metabolic process|membrane protein ectodomain proteolysis|axonogenesis|protein phosphorylation|generation of neurons|chordate embryonic development|regulation of T cell chemotaxis|zinc ion binding|metalloendopeptidase activity|transmembrane receptor protein tyrosine kinase signaling pathway|constitutive protein ectodomain proteolysis|ephrin receptor signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|in utero embryonic development|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K06704 disintegrin and metalloproteinase domain-containing protein 10[3.4.24.81] hsa05010|hsa05120 Alzheimer,s disease - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) 15:58588807-58749978 815 1063 1555 2896 3153 3383 2.51771060228775 2.98443066573607 4.33104642515812 8.01575656393733 7.9917184758609 9.79442801974979 3.27772923106065 8.60063435318267 -1.391746391756 9.60790252747928e-10 2.1246986818916e-08 DOWN ENSG00000131437 KIF3A kinesin family member 3A [Source:HGNC Symbol;Acc:HGNC:6319] GO:0032502|GO:0032991|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0008021|GO:0097159|GO:0044877|GO:0008283|GO:0050794|GO:0019882|GO:0043229|GO:0051050|GO:0006950|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0005929|GO:0048646|GO:0007507|GO:0008284|GO:0042127|GO:0050817|GO:0035239|GO:0051640|GO:0001822|GO:0009888|GO:0048468|GO:0019884|GO:0006810|GO:0035295|GO:0021766|GO:0051130|GO:0048839|GO:0005930|GO:0007275|GO:0060627|GO:0048513|GO:0043168|GO:0005874|GO:0030990|GO:0030900|GO:0001882|GO:0031982|GO:0051128|GO:0016817|GO:0007420|GO:0022607|GO:0045807|GO:0043231|GO:0030133|GO:0005737|GO:0007389|GO:0009611|GO:0060322|GO:0007423|GO:0006928|GO:0009887|GO:0032403|GO:0042592|GO:0051656|GO:0043005|GO:0021915|GO:0048729|GO:0048598|GO:0048568|GO:0050673|GO:0072372|GO:0005875|GO:0007154|GO:0061024|GO:0010970|GO:0007165|GO:0070062|GO:0051649|GO:0008092|GO:0061351|GO:0097542|GO:0002504|GO:0021543|GO:0021542|GO:0048002|GO:0000166|GO:0030030|GO:0048869|GO:0021537|GO:0007017|GO:0050878|GO:0006996|GO:0016192|GO:0050679|GO:0051650|GO:0015631|GO:0000902|GO:0005829|GO:0005813|GO:0003143|GO:0005871|GO:0060113|GO:0007166|GO:0002009|GO:0035639|GO:0072358|GO:0007417|GO:0031410|GO:0001655|GO:0043583|GO:0007596|GO:0035050|GO:0005815|GO:0001883|GO:0003007|GO:0048260|GO:0021761|GO:0031512|GO:0009790|GO:0008017|GO:0016023|GO:0016818|GO:0044782|GO:0070382|GO:0042060|GO:0046907|GO:0048872|GO:0072001|GO:0032549|GO:0003002|GO:0021532|GO:0007599|GO:0030031|GO:0060122|GO:0007018|GO:0030100|GO:0031988|GO:0061371|GO:0005876|GO:0050678|GO:0070925|GO:0060429|GO:0042384|GO:0032990|GO:0048562|GO:0007399|GO:0060562|GO:0017076|GO:0051648|GO:0030154|GO:0048858|GO:0072359|GO:0072384|GO:0005856|GO:0005819|GO:0031513|GO:0002495|GO:0030507|GO:0048666|GO:0030182|GO:0060271|GO:0035058|GO:1903887|GO:0009792|GO:0021904|GO:0032391|GO:0048259|GO:0047496|GO:0005524|GO:0007224|GO:0016939|GO:0030554|GO:0008544|GO:0001947|GO:0019886|GO:0015630|GO:0009855|GO:0009953|GO:0009952|GO:0036334|GO:0060119|GO:0006897|GO:0022008|GO:0030705|GO:0016462|GO:0048699|GO:0007368|GO:0017111|GO:0006898|GO:0043009|GO:0042490|GO:0072383|GO:0016887|GO:0001701|GO:0003774|GO:0003777|GO:0008574 developmental process|macromolecular complex|immune system process|synapse|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|synaptic vesicle|organic cyclic compound binding|macromolecular complex binding|cell proliferation|regulation of cellular process|antigen processing and presentation|intracellular organelle|positive regulation of transport|response to stress|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|heart development|positive regulation of cell proliferation|regulation of cell proliferation|coagulation|tube morphogenesis|organelle localization|kidney development|tissue development|cell development|antigen processing and presentation of exogenous antigen|transport|tube development|hippocampus development|positive regulation of cellular component organization|inner ear development|axoneme|multicellular organism development|regulation of vesicle-mediated transport|animal organ development|anion binding|microtubule|intraciliary transport particle|forebrain development|nucleoside binding|vesicle|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|brain development|cellular component assembly|positive regulation of endocytosis|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|pattern specification process|response to wounding|head development|sensory organ development|movement of cell or subcellular component|organ morphogenesis|protein complex binding|homeostatic process|establishment of organelle localization|neuron projection|neural tube development|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|epithelial cell proliferation|primary cilium|microtubule associated complex|cell communication|membrane organization|establishment of localization by movement along microtubule|signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|neural precursor cell proliferation|ciliary tip|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|pallium development|dentate gyrus development|antigen processing and presentation of peptide antigen|nucleotide binding|cell projection organization|cellular developmental process|telencephalon development|microtubule-based process|regulation of body fluid levels|organelle organization|vesicle-mediated transport|positive regulation of epithelial cell proliferation|establishment of vesicle localization|tubulin binding|cell morphogenesis|cytosol|centrosome|embryonic heart tube morphogenesis|kinesin complex|inner ear receptor cell differentiation|cell surface receptor signaling pathway|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|cardiovascular system development|central nervous system development|cytoplasmic vesicle|urogenital system development|ear development|blood coagulation|embryonic heart tube development|microtubule organizing center|purine nucleoside binding|heart morphogenesis|positive regulation of receptor-mediated endocytosis|limbic system development|motile primary cilium|embryo development|microtubule binding|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cilium organization|exocytic vesicle|wound healing|intracellular transport|homeostasis of number of cells|renal system development|ribonucleoside binding|regionalization|neural tube patterning|hemostasis|cell projection assembly|inner ear receptor stereocilium organization|microtubule-based movement|regulation of endocytosis|membrane-bounded vesicle|determination of heart left/right asymmetry|spindle microtubule|regulation of epithelial cell proliferation|organelle assembly|epithelium development|cilium assembly|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|purine nucleotide binding|vesicle localization|cell differentiation|cell projection morphogenesis|circulatory system development|organelle transport along microtubule|cytoskeleton|spindle|nonmotile primary cilium|antigen processing and presentation of peptide antigen via MHC class II|spectrin binding|neuron development|neuron differentiation|cilium morphogenesis|nonmotile primary cilium assembly|motile primary cilium assembly|embryo development ending in birth or egg hatching|dorsal/ventral neural tube patterning|photoreceptor connecting cilium|regulation of receptor-mediated endocytosis|vesicle transport along microtubule|ATP binding|smoothened signaling pathway|kinesin II complex|adenyl nucleotide binding|epidermis development|heart looping|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule cytoskeleton|determination of bilateral symmetry|dorsal/ventral pattern formation|anterior/posterior pattern specification|epidermal stem cell homeostasis|inner ear receptor cell development|endocytosis|neurogenesis|cytoskeleton-dependent intracellular transport|pyrophosphatase activity|generation of neurons|determination of left/right symmetry|nucleoside-triphosphatase activity|receptor-mediated endocytosis|chordate embryonic development|mechanoreceptor differentiation|plus-end-directed vesicle transport along microtubule|ATPase activity|in utero embryonic development|motor activity|microtubule motor activity|ATP-dependent microtubule motor activity, plus-end-directed - - - - 5:132692628-132737638 132 146 193 481 552 395 0.916949242443295 0.921727006142016 1.20876594989432 2.99372799306577 3.14613264710954 2.57155884429613 1.01581406615988 2.90380649482381 -1.51530896110626 9.74178791984692e-10 2.15271159555226e-08 DOWN ENSG00000158669 GPAT4 glycerol-3-phosphate acyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:20880] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0040008|GO:0009058|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0044255|GO:0009888|GO:0048468|GO:0006810|GO:0006082|GO:0007275|GO:0048513|GO:0034641|GO:0044281|GO:0019637|GO:0043231|GO:0016746|GO:0005737|GO:0035264|GO:0051186|GO:0006629|GO:0005783|GO:0048638|GO:0040014|GO:0048869|GO:0016021|GO:0044249|GO:0048732|GO:0050878|GO:0006790|GO:0030879|GO:0008654|GO:0046486|GO:0007589|GO:0006637|GO:0002064|GO:0006066|GO:0009308|GO:0006631|GO:0046470|GO:0006638|GO:0016747|GO:0007595|GO:0060429|GO:0006796|GO:0008610|GO:0046903|GO:0030154|GO:0048469|GO:0006644|GO:0030855|GO:0006656|GO:0046474|GO:0002066|GO:0006576|GO:0019752|GO:0006639|GO:0002070|GO:0006650|GO:0008374|GO:0006654|GO:0016024|GO:0002068|GO:0046473|GO:0046341|GO:0032787|GO:0046339|GO:0004366|GO:0006641|GO:0019432|GO:0002071|GO:0002067 developmental process|growth|cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|regulation of growth|biosynthetic process|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|anatomical structure development|organelle membrane|cellular lipid metabolic process|tissue development|cell development|transport|organic acid metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|multicellular organism growth|cofactor metabolic process|lipid metabolic process|endoplasmic reticulum|regulation of developmental growth|regulation of multicellular organism growth|cellular developmental process|integral component of membrane|cellular biosynthetic process|gland development|regulation of body fluid levels|sulfur compound metabolic process|mammary gland development|phospholipid biosynthetic process|glycerolipid metabolic process|body fluid secretion|acyl-CoA metabolic process|epithelial cell development|alcohol metabolic process|amine metabolic process|fatty acid metabolic process|phosphatidylcholine metabolic process|neutral lipid metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|lactation|epithelium development|phosphate-containing compound metabolic process|lipid biosynthetic process|secretion|cell differentiation|cell maturation|phospholipid metabolic process|epithelial cell differentiation|phosphatidylcholine biosynthetic process|glycerophospholipid biosynthetic process|columnar/cuboidal epithelial cell development|cellular biogenic amine metabolic process|carboxylic acid metabolic process|acylglycerol metabolic process|epithelial cell maturation|glycerophospholipid metabolic process|O-acyltransferase activity|phosphatidic acid biosynthetic process|CDP-diacylglycerol biosynthetic process|glandular epithelial cell development|phosphatidic acid metabolic process|CDP-diacylglycerol metabolic process|monocarboxylic acid metabolic process|diacylglycerol metabolic process|glycerol-3-phosphate O-acyltransferase activity|triglyceride metabolic process|triglyceride biosynthetic process|glandular epithelial cell maturation|glandular epithelial cell differentiation K13506 glycerol-3-phosphate O-acyltransferase 3/4[2.3.1.15] hsa01100|hsa00564|hsa00561 Metabolic pathways - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human) 8:41577187-41625001 1263 1282 1306 644 622 579 6.97265521835937 6.43225185077644 6.50058533991948 3.18550867059616 2.81743159571943 2.99572634923329 6.63516413635176 2.99955553851629 1.14538341038993 9.79231055593164e-10 2.16227543888153e-08 UP ENSG00000114331 ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 [Source:HGNC Symbol;Acc:HGNC:16469] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0043229|GO:0043167|GO:0051641|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0008047|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:1990089|GO:0043085|GO:0008104|GO:0010008|GO:0050790|GO:0010033|GO:0005768|GO:0005096|GO:0046872|GO:1990090|GO:0051345|GO:0030695|GO:0070848|GO:0034613|GO:0071310|GO:0051020|GO:0033365|GO:0071363|GO:0043087|GO:0043547|GO:0031267|GO:0017016|GO:0036010|GO:0017137 cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|intracellular organelle|ion binding|cellular localization|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|enzyme activator activity|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|response to nerve growth factor|positive regulation of catalytic activity|protein localization|endosome membrane|regulation of catalytic activity|response to organic substance|endosome|GTPase activator activity|metal ion binding|cellular response to nerve growth factor stimulus|positive regulation of hydrolase activity|GTPase regulator activity|response to growth factor|cellular protein localization|cellular response to organic substance|GTPase binding|protein localization to organelle|cellular response to growth factor stimulus|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase binding|Ras GTPase binding|protein localization to endosome|Rab GTPase binding K12489 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein[-] hsa04144 Endocytosis - Homo sapiens (human) 3:195274736-195443078 811 1055 1486 2685 3375 2986 3.87043604907517 4.57584637480717 6.39398971650438 11.4810316198471 13.2154113165896 13.3554215081641 4.94675738012891 12.6839548148669 -1.35844959555719 9.80921894047609e-10 2.16440814670342e-08 DOWN ENSG00000220201 ZGLP1 zinc finger, GATA-like protein 1 [Source:HGNC Symbol;Acc:HGNC:37245] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0043227|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0006725|GO:0048468|GO:0009994|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0000981|GO:0005667|GO:0009890|GO:0003682|GO:0006139|GO:0007276|GO:0008134|GO:0048869|GO:0044249|GO:0031324|GO:0007281|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0048232|GO:0046872|GO:0001085|GO:0010629|GO:0051252|GO:0048477|GO:0010628|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0048599|GO:0016070|GO:0007292|GO:0010557|GO:0005634|GO:0007283|GO:0000975|GO:0045893|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0046914|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0008270|GO:0000976|GO:0001012|GO:0000977 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|cellular aromatic compound metabolic process|cell development|oocyte differentiation|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor complex|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|gamete generation|transcription factor binding|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gamete generation|metal ion binding|RNA polymerase II transcription factor binding|negative regulation of gene expression|regulation of RNA metabolic process|oogenesis|positive regulation of gene expression|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|oocyte development|RNA metabolic process|female gamete generation|positive regulation of macromolecule biosynthetic process|nucleus|spermatogenesis|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 19:10304803-10309880 128 115 101 32 33 36 2.70116158205803 2.2055698579209 1.92166359808584 0.605048676970962 0.57138210363919 0.711983562231342 2.27613167935492 0.629471447613831 1.85437117832373 9.92886886666424e-10 2.18757528520586e-08 UP ENSG00000233016 SNHG7 small nucleolar RNA host gene 7 [Source:HGNC Symbol;Acc:HGNC:28254] - - - - - - 9:136721366-136728184 1916 1854 2138 949 842 995 27.407846592281 24.1029000207365 27.574102630177 12.1630757128831 9.88233358470414 13.339245118428 26.3616164143982 11.7948848053384 1.16027750616932 9.92433388162667e-10 2.18757528520586e-08 UP ENSG00000126062 TMEM115 transmembrane protein 115 [Source:HGNC Symbol;Acc:HGNC:30055] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0042802|GO:0006486|GO:0042127|GO:0006810|GO:0043231|GO:0005737|GO:0005975|GO:0045184|GO:0008104|GO:0051649|GO:0017119|GO:0008285|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0016192|GO:0034645|GO:0043412|GO:0015031|GO:0009100|GO:0036211|GO:0046907|GO:0070085|GO:0005795|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0005634|GO:0009101|GO:0043413|GO:0048193|GO:0031985|GO:0032580|GO:0006464|GO:0006890 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|identical protein binding|protein glycosylation|regulation of cell proliferation|transport|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|establishment of protein localization|protein localization|establishment of localization in cell|Golgi transport complex|negative regulation of cell proliferation|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|vesicle-mediated transport|cellular macromolecule biosynthetic process|macromolecule modification|protein transport|glycoprotein metabolic process|protein modification process|intracellular transport|glycosylation|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|nucleus|glycoprotein biosynthetic process|macromolecule glycosylation|Golgi vesicle transport|Golgi cisterna|Golgi cisterna membrane|cellular protein modification process|retrograde vesicle-mediated transport, Golgi to ER - - - - 3:50354749-50359610 1016 967 910 390 517 428 32.712158854247 28.295818108527 26.416245837448 11.2506595265858 13.6575910788794 12.9148363113035 29.141407600074 12.6076956389229 1.20876595235025 9.99459575279299e-10 2.20043260769825e-08 UP ENSG00000279692 RP11-1055B8.1 - - - - - - - 17:81395609-81397144 52 63 34 11 6 5 2.39475524489015 2.6368036820568 1.41171029917612 0.453878463261171 0.226695964491741 0.215819820077469 2.14775640870769 0.298798082610127 2.84558758151002 1.00234784296139e-09 2.20516525451506e-08 UP ENSG00000035141 FAM136A family with sequence similarity 136 member A [Source:HGNC Symbol;Acc:HGNC:25911] GO:0005623|GO:0005622|GO:0005737 cell|intracellular|cytoplasm - - - - 2:70295975-70302090 1829 1897 1345 691 767 432 19.7432753316144 18.6102798973423 13.0900723127925 6.68314701256519 6.79311115377711 4.37037057186704 17.1478758472497 5.94887624606978 1.5273408055548 1.04475987724426e-09 2.29677918816276e-08 UP ENSG00000260401 RP11-800A3.4 - - - - - - - 11:73238975-73242335 127 126 203 484 501 422 2.67289294572591 2.41005654923022 3.8520016183836 9.12683926519348 8.651330796903 8.32374602407531 2.97831703777991 8.7006386953906 -1.54662397501412 1.06291125041133e-09 2.33496338997645e-08 DOWN ENSG00000121892 PDS5A PDS5 cohesin associated factor A [Source:HGNC Symbol;Acc:HGNC:29088] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0071944|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0009890|GO:0006139|GO:0007059|GO:0051301|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005829|GO:0000819|GO:0034645|GO:0051053|GO:1903047|GO:0000278|GO:0031981|GO:0007062|GO:0005654|GO:0006259|GO:0005694|GO:0007067|GO:0009059|GO:0005634|GO:0008156|GO:0006260|GO:0007064|GO:0006275|GO:0000070|GO:0000775 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|cell periphery|biosynthetic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|chromosome segregation|cell division|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|cytosol|sister chromatid segregation|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|mitotic cell cycle process|mitotic cell cycle|nuclear lumen|sister chromatid cohesion|nucleoplasm|DNA metabolic process|chromosome|mitotic nuclear division|macromolecule biosynthetic process|nucleus|negative regulation of DNA replication|DNA replication|mitotic sister chromatid cohesion|regulation of DNA replication|mitotic sister chromatid segregation|chromosome, centromeric region - - - - 4:39822863-39977956 1868 2378 2829 5890 6798 5406 9.25649442069491 10.7093090642364 12.6391175719625 26.1506588220452 27.6387717999793 25.1058304167216 10.8683070189646 26.2984203462487 -1.27484891853408 1.06779677785386e-09 2.34397095632714e-08 DOWN ENSG00000272514 CFAP206 cilia and flagella associated protein 206 [Source:HGNC Symbol;Acc:HGNC:21405] GO:0005488|GO:0005515 binding|protein binding - - - - 6:87407983-87464465 13 5 15 79 60 64 0.191138941758594 0.0668191509152395 0.19884377588315 1.04072480989604 0.723816774057136 0.881906430716519 0.152267289518994 0.882149338223232 -2.5344168575667 1.09332751262839e-09 2.39825125363762e-08 DOWN ENSG00000135966 TGFBRAP1 transforming growth factor beta receptor associated protein 1 [Source:HGNC Symbol;Acc:HGNC:16836] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0005102|GO:0034641|GO:0046483|GO:0043231|GO:0046332|GO:0005737|GO:0033263|GO:0071559|GO:0045184|GO:0006139|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0051649|GO:0044249|GO:0010033|GO:0031323|GO:0005768|GO:0006996|GO:0061025|GO:0016192|GO:0010468|GO:0005126|GO:0034645|GO:0016050|GO:0007166|GO:0005769|GO:0051252|GO:0015031|GO:0071560|GO:0046907|GO:0070848|GO:0034613|GO:0010467|GO:0071310|GO:0009059|GO:0016070|GO:0048284|GO:0032774|GO:2001141|GO:0071363|GO:0007179|GO:0006886|GO:0006906|GO:0007167|GO:0016197|GO:0005160|GO:0007034|GO:0006351|GO:0006355|GO:0008333|GO:0007041|GO:1903506|GO:0034058|GO:0007178 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|SMAD binding|cytoplasm|CORVET complex|response to transforming growth factor beta|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|cell communication|membrane organization|signal transduction|establishment of localization in cell|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|endosome|organelle organization|membrane fusion|vesicle-mediated transport|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|vesicle organization|cell surface receptor signaling pathway|early endosome|regulation of RNA metabolic process|protein transport|cellular response to transforming growth factor beta stimulus|intracellular transport|response to growth factor|cellular protein localization|gene expression|cellular response to organic substance|macromolecule biosynthetic process|RNA metabolic process|organelle fusion|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|transforming growth factor beta receptor signaling pathway|intracellular protein transport|vesicle fusion|enzyme linked receptor protein signaling pathway|endosomal transport|transforming growth factor beta receptor binding|vacuolar transport|transcription, DNA-templated|regulation of transcription, DNA-templated|endosome to lysosome transport|lysosomal transport|regulation of nucleic acid-templated transcription|endosomal vesicle fusion|transmembrane receptor protein serine/threonine kinase signaling pathway - - - - 2:105264391-105330034 2383 2638 1622 854 1019 707 16.4342334432994 16.5340885523884 10.0853398074018 5.2769282262162 5.76590753985312 4.56955005092425 14.3512206010299 5.20412860566452 1.46344492648802 1.09857519578631e-09 2.40799294383294e-08 UP ENSG00000102359 SRPX2 sushi-repeat containing protein, X-linked 2 [Source:HGNC Symbol;Acc:HGNC:30668] GO:0040011|GO:0032502|GO:0045202|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0005488|GO:0050794|GO:0060076|GO:0040012|GO:0044089|GO:0009986|GO:0044237|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0044708|GO:0071944|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0051272|GO:0071625|GO:0016337|GO:0019838|GO:0051130|GO:0001568|GO:0007275|GO:0010632|GO:0005102|GO:0051128|GO:2000147|GO:0022607|GO:0098609|GO:0050803|GO:0005737|GO:0006928|GO:0051963|GO:0001525|GO:0051270|GO:0016477|GO:0051965|GO:0050808|GO:0010634|GO:2000145|GO:0031323|GO:0002040|GO:0090132|GO:0007416|GO:0001944|GO:0050807|GO:0072358|GO:0030334|GO:0001667|GO:0045766|GO:0045765|GO:0036458|GO:0006796|GO:1901342|GO:0051174|GO:0007399|GO:0010594|GO:0030335|GO:0072359|GO:0051960|GO:0010595|GO:1903672|GO:0043536|GO:0043535|GO:0016310|GO:0002042|GO:0010631|GO:0042325|GO:0090049|GO:0043542|GO:0090050|GO:0043534 locomotion|developmental process|synapse|behavior|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|binding|regulation of cellular process|excitatory synapse|regulation of locomotion|positive regulation of cellular component biogenesis|cell surface|cellular metabolic process|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|single-organism behavior|cell periphery|extracellular space|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|synaptic membrane|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|positive regulation of cellular component movement|vocalization behavior|single organismal cell-cell adhesion|growth factor binding|positive regulation of cellular component organization|blood vessel development|multicellular organism development|regulation of epithelial cell migration|receptor binding|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|cell-cell adhesion|regulation of synapse structure or activity|cytoplasm|movement of cell or subcellular component|regulation of synapse assembly|angiogenesis|regulation of cellular component movement|cell migration|positive regulation of synapse assembly|synapse organization|positive regulation of epithelial cell migration|regulation of cell motility|regulation of cellular metabolic process|sprouting angiogenesis|epithelium migration|synapse assembly|vasculature development|regulation of synapse organization|cardiovascular system development|regulation of cell migration|ameboidal-type cell migration|positive regulation of angiogenesis|regulation of angiogenesis|hepatocyte growth factor binding|phosphate-containing compound metabolic process|regulation of vasculature development|regulation of phosphorus metabolic process|nervous system development|regulation of endothelial cell migration|positive regulation of cell migration|circulatory system development|regulation of nervous system development|positive regulation of endothelial cell migration|positive regulation of sprouting angiogenesis|positive regulation of blood vessel endothelial cell migration|regulation of blood vessel endothelial cell migration|phosphorylation|cell migration involved in sprouting angiogenesis|epithelial cell migration|regulation of phosphorylation|regulation of cell migration involved in sprouting angiogenesis|endothelial cell migration|positive regulation of cell migration involved in sprouting angiogenesis|blood vessel endothelial cell migration - - - - X:100644218-100671299 68 88 168 399 370 543 1.70147897535264 2.00116115421228 3.79004094164589 8.94520502096372 7.59607173342097 12.7335241641764 2.49756035707027 9.7582669728537 -1.96610541076895 1.11049705622337e-09 2.43233889335968e-08 DOWN ENSG00000185164 NOMO2 NODAL modulator 2 [Source:HGNC Symbol;Acc:HGNC:22652] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0042175|GO:0030246|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0005737|GO:0005783|GO:0031647|GO:0016021|GO:0031648 cell|membrane|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|carbohydrate binding|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|regulation of protein stability|integral component of membrane|protein destabilization - - - - 16:18417325-18562211 1792 2023 2519 4969 5485 5306 12.3524110336741 12.6732960659956 15.6551102326654 30.6888369751772 31.0211797222711 34.2775588052937 13.5602724441117 31.995858500914 -1.23849901232377 1.11435677233517e-09 2.43721663599225e-08 DOWN ENSG00000189319 FAM53B family with sequence similarity 53 member B [Source:HGNC Symbol;Acc:HGNC:28968] - - - - - - 10:124619292-124744269 49 43 111 266 313 290 0.412828756173455 0.329250168420421 0.843163042014156 2.00794780008452 2.16364266934211 2.28981225929632 0.528413988869344 2.15380090957432 -2.02714433283652 1.11376924159496e-09 2.43721663599225e-08 DOWN ENSG00000021826 CPS1 carbamoyl-phosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:2323] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0044877|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0072341|GO:0051707|GO:0043227|GO:0008289|GO:0009607|GO:0009605|GO:0016787|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0042645|GO:0031090|GO:0006575|GO:0044262|GO:0044255|GO:0048565|GO:0006725|GO:0019866|GO:0009888|GO:0035295|GO:1901360|GO:0006082|GO:0009991|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0015980|GO:0044281|GO:2001057|GO:0005543|GO:0001882|GO:0019637|GO:0046483|GO:0019627|GO:0043231|GO:0043169|GO:0008233|GO:0010243|GO:0005737|GO:0006520|GO:0016810|GO:0005975|GO:0032403|GO:0042592|GO:0072593|GO:0043177|GO:1903524|GO:0031966|GO:0042493|GO:0006139|GO:0009617|GO:0055086|GO:0006629|GO:0009725|GO:0000166|GO:0006091|GO:0048869|GO:0032094|GO:0010035|GO:0044249|GO:0019538|GO:0010033|GO:0048732|GO:0003013|GO:0042594|GO:0006790|GO:0055114|GO:0009636|GO:0071774|GO:0005730|GO:0005740|GO:0005976|GO:0035150|GO:0046486|GO:0055123|GO:0046872|GO:0014074|GO:0033993|GO:0035639|GO:0016884|GO:0016743|GO:0002237|GO:0016042|GO:0048878|GO:0004087|GO:0044242|GO:0009308|GO:0046683|GO:0001883|GO:1901652|GO:0001889|GO:0071417|GO:0010038|GO:0044275|GO:0043200|GO:0000096|GO:0032549|GO:0046209|GO:0000052|GO:0005743|GO:0006638|GO:0016812|GO:0031981|GO:0043434|GO:0044344|GO:0050667|GO:0005977|GO:0008652|GO:0070848|GO:0000050|GO:0006508|GO:0005759|GO:0005739|GO:0051591|GO:0016052|GO:0070542|GO:0006112|GO:0014070|GO:0060429|GO:0010043|GO:0006796|GO:0043603|GO:0031406|GO:0014075|GO:0071310|GO:0017076|GO:0030154|GO:0007494|GO:0031667|GO:0008015|GO:0032870|GO:0032496|GO:0045909|GO:0005634|GO:0048545|GO:0097305|GO:0019240|GO:0071398|GO:0034201|GO:0004070|GO:0042312|GO:0030855|GO:1901653|GO:0005980|GO:0005524|GO:0071363|GO:0030554|GO:0046461|GO:0006206|GO:0005509|GO:0071407|GO:0060416|GO:0004088|GO:0070365|GO:0004175|GO:0006576|GO:0071375|GO:0050801|GO:0016597|GO:0019752|GO:0070409|GO:0006639|GO:0004151|GO:0071320|GO:0033762|GO:0071396|GO:0031960|GO:0000272|GO:0071548|GO:0050880|GO:0051384|GO:0006541|GO:0006525|GO:0071377|GO:0016595|GO:0042311|GO:0046464|GO:0055081|GO:0071400|GO:0006207|GO:0006641|GO:0006595|GO:0006526|GO:0019433 developmental process|macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|modified amino acid binding|response to other organism|membrane-bounded organelle|lipid binding|response to biotic stimulus|response to external stimulus|hydrolase activity|biosynthetic process|ligase activity|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|mitochondrial nucleoid|organelle membrane|cellular modified amino acid metabolic process|cellular carbohydrate metabolic process|cellular lipid metabolic process|digestive tract development|cellular aromatic compound metabolic process|organelle inner membrane|tissue development|tube development|organic cyclic compound metabolic process|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|reactive nitrogen species metabolic process|phospholipid binding|nucleoside binding|organophosphate metabolic process|heterocycle metabolic process|urea metabolic process|intracellular membrane-bounded organelle|cation binding|peptidase activity|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|carbohydrate metabolic process|protein complex binding|homeostatic process|reactive oxygen species metabolic process|organic acid binding|positive regulation of blood circulation|mitochondrial membrane|response to drug|nucleobase-containing compound metabolic process|response to bacterium|nucleobase-containing small molecule metabolic process|lipid metabolic process|response to hormone|nucleotide binding|generation of precursor metabolites and energy|cellular developmental process|response to food|response to inorganic substance|cellular biosynthetic process|protein metabolic process|response to organic substance|gland development|circulatory system process|response to starvation|sulfur compound metabolic process|oxidation-reduction process|response to toxic substance|response to fibroblast growth factor|nucleolus|mitochondrial envelope|polysaccharide metabolic process|regulation of tube size|glycerolipid metabolic process|digestive system development|metal ion binding|response to purine-containing compound|response to lipid|purine ribonucleoside triphosphate binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|carboxyl- or carbamoyltransferase activity|response to molecule of bacterial origin|lipid catabolic process|chemical homeostasis|carbamoyl-phosphate synthase (ammonia) activity|cellular lipid catabolic process|amine metabolic process|response to organophosphorus|purine nucleoside binding|response to peptide|liver development|cellular response to organonitrogen compound|response to metal ion|cellular carbohydrate catabolic process|response to amino acid|sulfur amino acid metabolic process|ribonucleoside binding|nitric oxide metabolic process|citrulline metabolic process|mitochondrial inner membrane|neutral lipid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides|nuclear lumen|response to peptide hormone|cellular response to fibroblast growth factor stimulus|homocysteine metabolic process|glycogen metabolic process|cellular amino acid biosynthetic process|response to growth factor|urea cycle|proteolysis|mitochondrial matrix|mitochondrion|response to cAMP|carbohydrate catabolic process|response to fatty acid|energy reserve metabolic process|response to organic cyclic compound|epithelium development|response to zinc ion|phosphate-containing compound metabolic process|cellular amide metabolic process|carboxylic acid binding|response to amine|cellular response to organic substance|purine nucleotide binding|cell differentiation|midgut development|response to nutrient levels|blood circulation|cellular response to hormone stimulus|response to lipopolysaccharide|positive regulation of vasodilation|nucleus|response to steroid hormone|response to alcohol|citrulline biosynthetic process|cellular response to fatty acid|response to oleic acid|aspartate carbamoyltransferase activity|regulation of vasodilation|epithelial cell differentiation|cellular response to peptide|glycogen catabolic process|ATP binding|cellular response to growth factor stimulus|adenyl nucleotide binding|neutral lipid catabolic process|pyrimidine nucleobase metabolic process|calcium ion binding|cellular response to organic cyclic compound|response to growth hormone|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|hepatocyte differentiation|endopeptidase activity|cellular biogenic amine metabolic process|cellular response to peptide hormone stimulus|ion homeostasis|amino acid binding|carboxylic acid metabolic process|carbamoyl phosphate biosynthetic process|acylglycerol metabolic process|dihydroorotase activity|cellular response to cAMP|response to glucagon|cellular response to lipid|response to corticosteroid|polysaccharide catabolic process|response to dexamethasone|regulation of blood vessel size|response to glucocorticoid|glutamine metabolic process|arginine metabolic process|cellular response to glucagon stimulus|glutamate binding|vasodilation|acylglycerol catabolic process|anion homeostasis|cellular response to oleic acid|'de novo' pyrimidine nucleobase biosynthetic process|triglyceride metabolic process|polyamine metabolic process|arginine biosynthetic process|triglyceride catabolic process K01948 carbamoyl-phosphate synthase (ammonia)[6.3.4.16] hsa01100|hsa01200|hsa01230|hsa00250|hsa00220|hsa00910 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human)|Arginine biosynthesis - Homo sapiens (human)|Nitrogen metabolism - Homo sapiens (human) 2:210477682-210679107 2 1 4 41 22 32 0.0118580994045541 0.00539125957560263 0.0213840911975569 0.217813812201354 0.107030001233475 0.17782279288253 0.0128778167259045 0.16755553543912 -3.70167942059725 1.11991833779509e-09 2.44758726621776e-08 DOWN ENSG00000072134 EPN2 epsin 2 [Source:HGNC Symbol;Acc:HGNC:18639] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006810|GO:0060627|GO:0031982|GO:0051128|GO:0030117|GO:0043231|GO:0005737|GO:0012506|GO:0030666|GO:0005794|GO:0016192|GO:0031410|GO:0016023|GO:0030665|GO:0031981|GO:0030100|GO:0031988|GO:0005654|GO:0030118|GO:0030669|GO:0030659|GO:0030120|GO:0005634|GO:0030139|GO:0030125|GO:0030135|GO:0030128|GO:0006897|GO:0030136|GO:0045334 macromolecular complex|cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|lipid binding|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|transport|regulation of vesicle-mediated transport|vesicle|regulation of cellular component organization|membrane coat|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|endocytic vesicle membrane|Golgi apparatus|vesicle-mediated transport|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|nuclear lumen|regulation of endocytosis|membrane-bounded vesicle|nucleoplasm|clathrin coat|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle membrane|vesicle coat|nucleus|endocytic vesicle|clathrin vesicle coat|coated vesicle|clathrin coat of endocytic vesicle|endocytosis|clathrin-coated vesicle|clathrin-coated endocytic vesicle K12471 epsin[-] hsa04144 Endocytosis - Homo sapiens (human) 17:19215615-19336715 367 379 782 1546 1584 1639 1.26722851847755 1.18934481658817 2.43450007042414 4.78294757312995 4.48757471503919 5.30391225260703 1.63035780182995 4.85814484692539 -1.57521688880371 1.13022074421507e-09 2.46829627635675e-08 DOWN ENSG00000171723 GPHN gephyrin [Source:HGNC Symbol;Acc:HGNC:15465] GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0071944|GO:0009058|GO:0005622|GO:0005886|GO:0016740|GO:0097060|GO:1901360|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0045211|GO:0051668|GO:0043169|GO:0005737|GO:0061599|GO:0051186|GO:0008104|GO:0061024|GO:0050808|GO:0000166|GO:0044249|GO:0019538|GO:0043113|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0006777|GO:0032549|GO:0072657|GO:0034613|GO:0006796|GO:0001941|GO:0044267|GO:0072578|GO:0017076|GO:0016779|GO:0043545|GO:0005856|GO:0006766|GO:0005524|GO:0030554|GO:0032324|GO:0009108|GO:0072579|GO:0006464|GO:0006767|GO:0061598|GO:0018315 synapse|cell|membrane|cellular process|metabolic process|cell junction|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|cell periphery|biosynthetic process|intracellular|plasma membrane|transferase activity|synaptic membrane|organic cyclic compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|postsynaptic membrane|localization within membrane|cation binding|cytoplasm|molybdopterin molybdotransferase activity|cofactor metabolic process|protein localization|membrane organization|synapse organization|nucleotide binding|cellular biosynthetic process|protein metabolic process|receptor clustering|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|Mo-molybdopterin cofactor biosynthetic process|ribonucleoside binding|protein localization to membrane|cellular protein localization|phosphate-containing compound metabolic process|postsynaptic membrane organization|cellular protein metabolic process|neurotransmitter-gated ion channel clustering|purine nucleotide binding|nucleotidyltransferase activity|molybdopterin cofactor metabolic process|cytoskeleton|vitamin metabolic process|ATP binding|adenyl nucleotide binding|molybdopterin cofactor biosynthetic process|coenzyme biosynthetic process|glycine receptor clustering|cellular protein modification process|water-soluble vitamin metabolic process|molybdopterin adenylyltransferase activity|molybdenum incorporation into molybdenum-molybdopterin complex K15376 gephyrin[2.7.7.75] hsa04727 GABAergic synapse - Homo sapiens (human) 14:66507407-67181803 61 97 184 435 461 468 0.445854438226825 0.644337541468032 1.21252612374732 2.84870233208291 2.76457757470022 3.2057870694404 0.767572701147392 2.93968899207451 -1.93728822361563 1.1386807520977e-09 2.4849543255208e-08 DOWN ENSG00000116096 SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) [Source:HGNC Symbol;Acc:HGNC:11257] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0048037|GO:0009058|GO:0005622|GO:0019222|GO:1903409|GO:0006725|GO:1901360|GO:0034641|GO:0044281|GO:2001057|GO:0031982|GO:0046483|GO:0016614|GO:0043231|GO:0005737|GO:0072593|GO:0051186|GO:0070062|GO:0050662|GO:0050790|GO:0000166|GO:0044249|GO:0055114|GO:0005829|GO:0050661|GO:0046209|GO:0042558|GO:0016616|GO:0031981|GO:0005654|GO:0051341|GO:0006809|GO:0005634|GO:0004757|GO:0042559|GO:0009108|GO:0046146|GO:0004033|GO:0006729|GO:0050999 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cofactor binding|biosynthetic process|intracellular|regulation of metabolic process|reactive oxygen species biosynthetic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|reactive nitrogen species metabolic process|vesicle|heterocycle metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cytoplasm|reactive oxygen species metabolic process|cofactor metabolic process|extracellular exosome|coenzyme binding|regulation of catalytic activity|nucleotide binding|cellular biosynthetic process|oxidation-reduction process|cytosol|NADP binding|nitric oxide metabolic process|pteridine-containing compound metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|nuclear lumen|nucleoplasm|regulation of oxidoreductase activity|nitric oxide biosynthetic process|nucleus|sepiapterin reductase activity|pteridine-containing compound biosynthetic process|coenzyme biosynthetic process|tetrahydrobiopterin metabolic process|aldo-keto reductase (NADP) activity|tetrahydrobiopterin biosynthetic process|regulation of nitric-oxide synthase activity K00072 sepiapterin reductase[1.1.1.153] hsa01100|hsa00790 Metabolic pathways - Homo sapiens (human)|Folate biosynthesis - Homo sapiens (human) 2:72887360-72892158 1905 2137 1231 675 749 503 55.522743747806 56.6057341022912 32.348061880167 17.6269603831242 17.9112419715593 13.7395510561458 48.1588465767547 16.4259178036098 1.5518268555358 1.16083468875568e-09 2.53145060614406e-08 UP ENSG00000173402 DAG1 dystroglycan 1 [Source:HGNC Symbol;Acc:HGNC:2666] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0005604|GO:1903561|GO:0051716|GO:0040013|GO:0042995|GO:0004872|GO:0009892|GO:0050840|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0040012|GO:0070938|GO:0043229|GO:0005578|GO:0044089|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0019867|GO:0071944|GO:0009605|GO:0023057|GO:0031252|GO:0031224|GO:0005615|GO:0050793|GO:0008307|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0097060|GO:0048646|GO:0019222|GO:0016032|GO:0008360|GO:0006935|GO:0045595|GO:0035239|GO:0009888|GO:0048468|GO:0016323|GO:0006810|GO:0035295|GO:0051130|GO:0098797|GO:0007275|GO:0030324|GO:0048513|GO:0005924|GO:0043062|GO:0001618|GO:0005912|GO:0031982|GO:0051128|GO:0045211|GO:0022607|GO:0043231|GO:0043169|GO:0010243|GO:1901201|GO:0051651|GO:0005737|GO:0001763|GO:0006928|GO:0009887|GO:0032403|GO:0043005|GO:1901203|GO:0031589|GO:0009966|GO:0048729|GO:0030027|GO:0048598|GO:0045184|GO:0042383|GO:0030323|GO:0019904|GO:0010646|GO:0010171|GO:0008104|GO:0007154|GO:0051270|GO:0009279|GO:0016477|GO:0007165|GO:0005913|GO:0043236|GO:0009968|GO:0070062|GO:0051649|GO:0008092|GO:0009725|GO:0021675|GO:0051271|GO:0030030|GO:0043034|GO:0030313|GO:0001948|GO:0048869|GO:0016021|GO:2000145|GO:0007017|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031324|GO:0040019|GO:0031323|GO:2000146|GO:0048732|GO:0006996|GO:0051701|GO:0000165|GO:0019048|GO:0060425|GO:0015631|GO:0032268|GO:0000902|GO:0031175|GO:0010172|GO:0043237|GO:0046872|GO:2000736|GO:0002009|GO:0030424|GO:0043412|GO:0072594|GO:0007010|GO:0021782|GO:1903053|GO:0060541|GO:0003779|GO:0010717|GO:0048754|GO:0015031|GO:1901652|GO:0061138|GO:0022612|GO:0000904|GO:0009790|GO:0030334|GO:0016010|GO:0036211|GO:0032269|GO:0007369|GO:0007160|GO:1904261|GO:0046907|GO:0044304|GO:0042805|GO:0007431|GO:0043292|GO:0060485|GO:0031981|GO:0043434|GO:0016476|GO:0007016|GO:0016011|GO:0032507|GO:0017166|GO:0006508|GO:0005654|GO:0022604|GO:0021682|GO:0085029|GO:0030175|GO:0035272|GO:0030336|GO:0034613|GO:0060429|GO:0006796|GO:0035556|GO:0042169|GO:0044267|GO:0051174|GO:0048864|GO:0017038|GO:0032990|GO:0007399|GO:0060562|GO:0019058|GO:0097485|GO:1902532|GO:0030198|GO:0002162|GO:0051246|GO:0010470|GO:0030154|GO:0048858|GO:0045121|GO:1902531|GO:0000226|GO:0005856|GO:0005634|GO:0006606|GO:0033268|GO:0005925|GO:0045995|GO:0008366|GO:0007422|GO:0048666|GO:0030182|GO:0034453|GO:0051896|GO:0007411|GO:0043491|GO:0048863|GO:0014044|GO:0033365|GO:0030016|GO:0051898|GO:0010001|GO:0051393|GO:0051169|GO:0043408|GO:0010769|GO:0002011|GO:0046718|GO:0070831|GO:0006607|GO:0014031|GO:0016310|GO:0006605|GO:0033619|GO:0016340|GO:0005509|GO:0071711|GO:0061564|GO:0006886|GO:0060445|GO:0043409|GO:0048762|GO:0007435|GO:0060441|GO:0042552|GO:0022008|GO:0030260|GO:0048667|GO:0006464|GO:0048812|GO:0001837|GO:0014037|GO:0006509|GO:0006913|GO:0007409|GO:0006468|GO:0048699|GO:0042325|GO:0001932|GO:0022011|GO:0042326|GO:0042063|GO:0071679|GO:0001933|GO:0034504|GO:0051170 locomotion|developmental process|extracellular matrix|macromolecular complex|synapse|structural molecule activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|basement membrane|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|cell projection|receptor activity|negative regulation of metabolic process|extracellular matrix binding|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|regulation of locomotion|contractile ring|intracellular organelle|proteinaceous extracellular matrix|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|outer membrane|cell periphery|response to external stimulus|negative regulation of signaling|cell leading edge|intrinsic component of membrane|extracellular space|regulation of developmental process|structural constituent of muscle|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|synaptic membrane|anatomical structure formation involved in morphogenesis|regulation of metabolic process|viral process|regulation of cell shape|chemotaxis|regulation of cell differentiation|tube morphogenesis|tissue development|cell development|basolateral plasma membrane|transport|tube development|positive regulation of cellular component organization|plasma membrane protein complex|multicellular organism development|lung development|animal organ development|cell-substrate adherens junction|extracellular structure organization|virus receptor activity|adherens junction|vesicle|regulation of cellular component organization|postsynaptic membrane|cellular component assembly|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|regulation of extracellular matrix assembly|maintenance of location in cell|cytoplasm|morphogenesis of a branching structure|movement of cell or subcellular component|organ morphogenesis|protein complex binding|neuron projection|positive regulation of extracellular matrix assembly|cell-substrate adhesion|regulation of signal transduction|tissue morphogenesis|lamellipodium|embryonic morphogenesis|establishment of protein localization|sarcolemma|respiratory tube development|protein domain specific binding|regulation of cell communication|body morphogenesis|protein localization|cell communication|regulation of cellular component movement|cell outer membrane|cell migration|signal transduction|cell-cell adherens junction|laminin binding|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|response to hormone|nerve development|negative regulation of cellular component movement|cell projection organization|costamere|cell envelope|glycoprotein binding|cellular developmental process|integral component of membrane|regulation of cell motility|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|positive regulation of embryonic development|regulation of cellular metabolic process|negative regulation of cell motility|gland development|organelle organization|interaction with host|MAPK cascade|modulation by virus of host morphology or physiology|lung morphogenesis|tubulin binding|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|embryonic body morphogenesis|laminin-1 binding|metal ion binding|regulation of stem cell differentiation|morphogenesis of an epithelium|axon|macromolecule modification|establishment of protein localization to organelle|cytoskeleton organization|glial cell development|regulation of extracellular matrix organization|respiratory system development|actin binding|regulation of epithelial to mesenchymal transition|branching morphogenesis of an epithelial tube|protein transport|response to peptide|morphogenesis of a branching epithelium|gland morphogenesis|cell morphogenesis involved in differentiation|embryo development|regulation of cell migration|dystrophin-associated glycoprotein complex|protein modification process|negative regulation of cellular protein metabolic process|gastrulation|cell-matrix adhesion|positive regulation of basement membrane assembly involved in embryonic body morphogenesis|intracellular transport|main axon|actinin binding|salivary gland development|contractile fiber|mesenchyme development|nuclear lumen|response to peptide hormone|regulation of embryonic cell shape|cytoskeletal anchoring at plasma membrane|dystroglycan complex|maintenance of protein location in cell|vinculin binding|proteolysis|nucleoplasm|regulation of cell morphogenesis|nerve maturation|extracellular matrix assembly|filopodium|exocrine system development|negative regulation of cell migration|cellular protein localization|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|SH2 domain binding|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|protein import|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|viral life cycle|neuron projection guidance|negative regulation of intracellular signal transduction|extracellular matrix organization|dystroglycan binding|regulation of protein metabolic process|regulation of gastrulation|cell differentiation|cell projection morphogenesis|membrane raft|regulation of intracellular signal transduction|microtubule cytoskeleton organization|cytoskeleton|nucleus|protein import into nucleus|node of Ranvier|focal adhesion|regulation of embryonic development|axon ensheathment|peripheral nervous system development|neuron development|neuron differentiation|microtubule anchoring|regulation of protein kinase B signaling|axon guidance|protein kinase B signaling|stem cell differentiation|Schwann cell development|protein localization to organelle|myofibril|negative regulation of protein kinase B signaling|glial cell differentiation|alpha-actinin binding|nuclear transport|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|morphogenesis of an epithelial sheet|viral entry into host cell|basement membrane assembly|NLS-bearing protein import into nucleus|mesenchymal cell development|phosphorylation|protein targeting|membrane protein proteolysis|calcium-dependent cell-matrix adhesion|calcium ion binding|basement membrane organization|axon development|intracellular protein transport|branching involved in salivary gland morphogenesis|negative regulation of MAPK cascade|mesenchymal cell differentiation|salivary gland morphogenesis|epithelial tube branching involved in lung morphogenesis|myelination|neurogenesis|entry into host cell|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|epithelial to mesenchymal transition|Schwann cell differentiation|membrane protein ectodomain proteolysis|nucleocytoplasmic transport|axonogenesis|protein phosphorylation|generation of neurons|regulation of phosphorylation|regulation of protein phosphorylation|myelination in peripheral nervous system|negative regulation of phosphorylation|gliogenesis|commissural neuron axon guidance|negative regulation of protein phosphorylation|protein localization to nucleus|nuclear import K06265 dystroglycan 1[-] hsa05414|hsa05410|hsa04512|hsa05412|hsa05416 Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)|Viral myocarditis - Homo sapiens (human) 3:49468703-49535618 1613 1842 2228 4568 5058 4455 6.15086636343809 6.38368695296998 7.66004467327343 15.6072231126571 15.8251774910852 15.9212985158192 6.73153266322717 15.7845663731872 -1.22950770196946 1.16705168275672e-09 2.54315043335907e-08 DOWN ENSG00000198353 HOXC4 homeobox C4 [Source:HGNC Symbol;Acc:HGNC:5126] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0007389|GO:0009887|GO:0048598|GO:0048568|GO:0019904|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051216|GO:0051252|GO:0071837|GO:0009790|GO:0003002|GO:0010467|GO:0048562|GO:0009059|GO:0001501|GO:0061448|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0009952|GO:0006351|GO:0006355|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|pattern specification process|organ morphogenesis|embryonic morphogenesis|embryonic organ development|protein domain specific binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|regulation of RNA metabolic process|HMG box domain binding|embryo development|regionalization|gene expression|embryonic organ morphogenesis|macromolecule biosynthetic process|skeletal system development|connective tissue development|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|anterior/posterior pattern specification|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 12:54016931-54056030 2 4 2 41 34 22 0.0375742698263825 0.0682999225275639 0.0338794432917469 0.690177630693799 0.524111000699597 0.387383253269855 0.0465845452152311 0.533890628221084 -3.51862091044559 1.17414752665148e-09 2.55674691908485e-08 DOWN ENSG00000107249 GLIS3 GLIS family zinc finger 3 [Source:HGNC Symbol;Acc:HGNC:28510] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0012505|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0005794|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|endomembrane system|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 9:3824127-4348392 3 6 17 54 67 56 0.0120211735666352 0.0218478511738554 0.0614099977211702 0.193850909337014 0.22025209453597 0.210280110926368 0.0317596741538869 0.208127704933117 -2.7122010063133 1.17525287688675e-09 2.55728858502749e-08 DOWN ENSG00000154822 PLCL2 phospholipase C like 2 [Source:HGNC Symbol;Acc:HGNC:9064] GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0002683|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0023051|GO:0023057|GO:0016787|GO:0002684|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0002757|GO:0050804|GO:0070661|GO:0007275|GO:0048513|GO:0005102|GO:0016788|GO:0051098|GO:0005737|GO:0007267|GO:0001775|GO:0002312|GO:0009966|GO:0002263|GO:0010646|GO:0050776|GO:0046649|GO:0007154|GO:0006629|GO:0007165|GO:0002366|GO:0050778|GO:0009968|GO:0002322|GO:0048869|GO:0019538|GO:0031323|GO:0032268|GO:0050859|GO:0007186|GO:0042113|GO:0032943|GO:0007166|GO:0043412|GO:0030097|GO:0030098|GO:0016042|GO:0036211|GO:0002429|GO:0050811|GO:0051099|GO:0002764|GO:0016298|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:0046651|GO:0030154|GO:0042578|GO:0032228|GO:0043393|GO:0002521|GO:0004620|GO:0008081|GO:0030183|GO:0007214|GO:0016310|GO:0002768|GO:0032092|GO:0050855|GO:0042100|GO:0006464|GO:0050851|GO:0004629|GO:0006468|GO:0042325|GO:1900122|GO:0001932|GO:0018193|GO:0002335|GO:0050853|GO:0007268|GO:0004435|GO:0007270|GO:0001923|GO:0018105|GO:0033135|GO:0002337|GO:0051932 developmental process|signal transducer activity|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of immune system process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|regulation of signaling|negative regulation of signaling|hydrolase activity|positive regulation of immune system process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|immune response-activating signal transduction|modulation of synaptic transmission|leukocyte proliferation|multicellular organism development|animal organ development|receptor binding|hydrolase activity, acting on ester bonds|regulation of binding|cytoplasm|cell-cell signaling|cell activation|B cell activation involved in immune response|regulation of signal transduction|cell activation involved in immune response|regulation of cell communication|regulation of immune response|lymphocyte activation|cell communication|lipid metabolic process|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|negative regulation of signal transduction|B cell proliferation involved in immune response|cellular developmental process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|negative regulation of B cell receptor signaling pathway|G-protein coupled receptor signaling pathway|B cell activation|mononuclear cell proliferation|cell surface receptor signaling pathway|macromolecule modification|hemopoiesis|lymphocyte differentiation|lipid catabolic process|protein modification process|immune response-activating cell surface receptor signaling pathway|GABA receptor binding|positive regulation of binding|immune response-regulating signaling pathway|lipase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|lymphocyte proliferation|cell differentiation|phosphoric ester hydrolase activity|regulation of synaptic transmission, GABAergic|regulation of protein binding|leukocyte differentiation|phospholipase activity|phosphoric diester hydrolase activity|B cell differentiation|gamma-aminobutyric acid signaling pathway|phosphorylation|immune response-regulating cell surface receptor signaling pathway|positive regulation of protein binding|regulation of B cell receptor signaling pathway|B cell proliferation|cellular protein modification process|antigen receptor-mediated signaling pathway|phospholipase C activity|protein phosphorylation|regulation of phosphorylation|positive regulation of receptor binding|regulation of protein phosphorylation|peptidyl-amino acid modification|mature B cell differentiation|B cell receptor signaling pathway|synaptic transmission|phosphatidylinositol phospholipase C activity|neuron-neuron synaptic transmission|B-1 B cell differentiation|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|B-1a B cell differentiation|synaptic transmission, GABAergic - - - - 3:16802651-17090594 14 14 9 88 84 52 0.119793896482788 0.108869266857019 0.0694289456627014 0.674648926426191 0.589720424401114 0.416993088199317 0.0993640363341695 0.560454146342207 -2.49580065894324 1.17899249022055e-09 2.56355730539288e-08 DOWN ENSG00000134744 ZCCHC11 zinc finger, CCHC domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28981] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0031664|GO:0034641|GO:0016772|GO:0031982|GO:0046483|GO:0001817|GO:0043231|GO:0043169|GO:0005737|GO:0001816|GO:0009966|GO:0009890|GO:0001819|GO:0016458|GO:0010646|GO:0006139|GO:0009617|GO:0007154|GO:0044092|GO:0007165|GO:0070062|GO:0044249|GO:0019827|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0051090|GO:0005730|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0003723|GO:0007166|GO:0033993|GO:0032675|GO:0034097|GO:0032635|GO:0031047|GO:0010629|GO:0002237|GO:0051252|GO:0044265|GO:0032755|GO:0032269|GO:0043331|GO:0071219|GO:0031981|GO:0043433|GO:0014070|GO:0043603|GO:0044267|GO:0010467|GO:0071310|GO:0019439|GO:0051246|GO:0009059|GO:0016779|GO:0016070|GO:0032496|GO:0005634|GO:0016441|GO:0006401|GO:0043043|GO:0019221|GO:0006396|GO:0045892|GO:0032774|GO:0017148|GO:0034660|GO:0071359|GO:2001141|GO:0010608|GO:1902679|GO:0071407|GO:0006412|GO:0040029|GO:0006417|GO:0070569|GO:0071345|GO:0035196|GO:0032088|GO:0046914|GO:0044822|GO:0071396|GO:0006351|GO:0035194|GO:0006355|GO:0071222|GO:0070741|GO:0031663|GO:1903507|GO:0050265|GO:1903506|GO:0071354|GO:0070102|GO:0031054|GO:0035195|GO:0008270|GO:0010586|GO:0031123|GO:0010587 developmental process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|extracellular space|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|regulation of lipopolysaccharide-mediated signaling pathway|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|vesicle|heterocycle metabolic process|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|cytoplasm|cytokine production|regulation of signal transduction|negative regulation of biosynthetic process|positive regulation of cytokine production|gene silencing|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|cell communication|negative regulation of molecular function|signal transduction|extracellular exosome|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|nucleolus|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|RNA binding|cell surface receptor signaling pathway|response to lipid|regulation of interleukin-6 production|response to cytokine|interleukin-6 production|gene silencing by RNA|negative regulation of gene expression|response to molecule of bacterial origin|regulation of RNA metabolic process|cellular macromolecule catabolic process|positive regulation of interleukin-6 production|negative regulation of cellular protein metabolic process|response to dsRNA|cellular response to molecule of bacterial origin|nuclear lumen|negative regulation of sequence-specific DNA binding transcription factor activity|response to organic cyclic compound|cellular amide metabolic process|cellular protein metabolic process|gene expression|cellular response to organic substance|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|response to lipopolysaccharide|nucleus|posttranscriptional gene silencing|RNA catabolic process|peptide biosynthetic process|cytokine-mediated signaling pathway|RNA processing|negative regulation of transcription, DNA-templated|RNA biosynthetic process|negative regulation of translation|ncRNA metabolic process|cellular response to dsRNA|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|translation|regulation of gene expression, epigenetic|regulation of translation|uridylyltransferase activity|cellular response to cytokine stimulus|production of miRNAs involved in gene silencing by miRNA|negative regulation of NF-kappaB transcription factor activity|transition metal ion binding|poly(A) RNA binding|cellular response to lipid|transcription, DNA-templated|posttranscriptional gene silencing by RNA|regulation of transcription, DNA-templated|cellular response to lipopolysaccharide|response to interleukin-6|lipopolysaccharide-mediated signaling pathway|negative regulation of nucleic acid-templated transcription|RNA uridylyltransferase activity|regulation of nucleic acid-templated transcription|cellular response to interleukin-6|interleukin-6-mediated signaling pathway|pre-miRNA processing|gene silencing by miRNA|zinc ion binding|miRNA metabolic process|RNA 3'-end processing|miRNA catabolic process - - - - 1:52408282-52553487 458 551 930 1679 1886 2154 1.26350360095489 1.38147240241118 2.31317238581988 4.15010697578515 4.26894405707289 5.5691044342345 1.65271612972865 4.66271848903085 -1.49633238097056 1.18812736114954e-09 2.58153960988053e-08 DOWN ENSG00000128917 DLL4 delta-like 4 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:2910] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0007155|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0008284|GO:0042127|GO:0016337|GO:0045595|GO:0035239|GO:0006725|GO:0060041|GO:0009888|GO:0048468|GO:0035295|GO:1901360|GO:0001568|GO:0007275|GO:0010632|GO:0048513|GO:0050877|GO:0070489|GO:0005102|GO:0034641|GO:0021517|GO:0046483|GO:0098609|GO:0061061|GO:0043169|GO:0007389|GO:0001763|GO:0007423|GO:0006928|GO:0009887|GO:0001775|GO:0003407|GO:0009966|GO:0048729|GO:0048598|GO:0050673|GO:0048771|GO:0009890|GO:0010646|GO:0006139|GO:0001525|GO:0046649|GO:0007154|GO:0051270|GO:0061383|GO:0016477|GO:0007165|GO:0009968|GO:0061351|GO:0051271|GO:0008285|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0044249|GO:0010633|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:2000146|GO:0003013|GO:0003205|GO:0071774|GO:0005112|GO:0016525|GO:0060039|GO:0002040|GO:0010468|GO:0090132|GO:0034645|GO:0046872|GO:0007166|GO:0001654|GO:0002009|GO:0001569|GO:0003208|GO:0001944|GO:0030097|GO:0072358|GO:0030098|GO:0007417|GO:0010629|GO:0061314|GO:0051252|GO:0021510|GO:0048738|GO:0003007|GO:0048754|GO:0061138|GO:0061074|GO:0009790|GO:0010628|GO:0030334|GO:0001935|GO:0001667|GO:0060840|GO:0060537|GO:0048844|GO:0003002|GO:0007600|GO:0003231|GO:0045765|GO:0045747|GO:0044344|GO:0007159|GO:0021514|GO:0070848|GO:0008593|GO:0003209|GO:0050678|GO:0050680|GO:0001974|GO:0030336|GO:0042110|GO:0060429|GO:1901342|GO:0044267|GO:0010467|GO:2000179|GO:0007399|GO:0060562|GO:0071310|GO:0010594|GO:0003344|GO:0060415|GO:0009059|GO:0030154|GO:0007517|GO:2000177|GO:0016070|GO:0072359|GO:0008015|GO:0072554|GO:0010596|GO:0061384|GO:0051960|GO:0045165|GO:0045746|GO:0048644|GO:0030182|GO:0002521|GO:0003158|GO:0021953|GO:0050953|GO:0045892|GO:0043010|GO:0002011|GO:0007220|GO:0032774|GO:2001141|GO:0030217|GO:0071363|GO:0043537|GO:0043535|GO:0021515|GO:1902679|GO:0005509|GO:0002043|GO:0002042|GO:0070486|GO:0048663|GO:0001936|GO:0061154|GO:0003222|GO:0009953|GO:0035909|GO:0001937|GO:0010631|GO:0035904|GO:0003229|GO:1903671|GO:0055008|GO:0007219|GO:0021511|GO:0014706|GO:0022008|GO:0055010|GO:0050767|GO:0060579|GO:0006351|GO:0006355|GO:0021513|GO:0006366|GO:0035912|GO:1903507|GO:0006357|GO:0048699|GO:1903506|GO:0090051|GO:1903588|GO:0035924|GO:0035907|GO:0090049|GO:0000122|GO:0007601|GO:0043542|GO:0071593|GO:0043534 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cell adhesion|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|immune system development|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|regulation of cell proliferation|single organismal cell-cell adhesion|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|retina development in camera-type eye|tissue development|cell development|tube development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|regulation of epithelial cell migration|animal organ development|neurological system process|T cell aggregation|receptor binding|cellular nitrogen compound metabolic process|ventral spinal cord development|heterocycle metabolic process|cell-cell adhesion|muscle structure development|cation binding|pattern specification process|morphogenesis of a branching structure|sensory organ development|movement of cell or subcellular component|organ morphogenesis|cell activation|neural retina development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|epithelial cell proliferation|tissue remodeling|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|lymphocyte activation|cell communication|regulation of cellular component movement|trabecula morphogenesis|cell migration|signal transduction|negative regulation of signal transduction|neural precursor cell proliferation|negative regulation of cellular component movement|negative regulation of cell proliferation|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|negative regulation of epithelial cell migration|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|circulatory system process|cardiac chamber development|response to fibroblast growth factor|Notch binding|negative regulation of angiogenesis|pericardium development|sprouting angiogenesis|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|patterning of blood vessels|cardiac ventricle morphogenesis|vasculature development|hemopoiesis|cardiovascular system development|lymphocyte differentiation|central nervous system development|negative regulation of gene expression|Notch signaling involved in heart development|regulation of RNA metabolic process|spinal cord development|cardiac muscle tissue development|heart morphogenesis|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|regulation of neural retina development|embryo development|positive regulation of gene expression|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|artery development|muscle tissue development|artery morphogenesis|regionalization|sensory perception|cardiac ventricle development|regulation of angiogenesis|positive regulation of Notch signaling pathway|cellular response to fibroblast growth factor stimulus|leukocyte cell-cell adhesion|ventral spinal cord interneuron differentiation|response to growth factor|regulation of Notch signaling pathway|cardiac atrium morphogenesis|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|blood vessel remodeling|negative regulation of cell migration|T cell activation|epithelium development|regulation of vasculature development|cellular protein metabolic process|gene expression|positive regulation of neural precursor cell proliferation|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|regulation of endothelial cell migration|pericardium morphogenesis|muscle tissue morphogenesis|macromolecule biosynthetic process|cell differentiation|muscle organ development|regulation of neural precursor cell proliferation|RNA metabolic process|circulatory system development|blood circulation|blood vessel lumenization|negative regulation of endothelial cell migration|heart trabecula morphogenesis|regulation of nervous system development|cell fate commitment|negative regulation of Notch signaling pathway|muscle organ morphogenesis|neuron differentiation|leukocyte differentiation|endothelium development|central nervous system neuron differentiation|sensory perception of light stimulus|negative regulation of transcription, DNA-templated|camera-type eye development|morphogenesis of an epithelial sheet|Notch receptor processing|RNA biosynthetic process|regulation of RNA biosynthetic process|T cell differentiation|cellular response to growth factor stimulus|negative regulation of blood vessel endothelial cell migration|regulation of blood vessel endothelial cell migration|cell differentiation in spinal cord|negative regulation of RNA biosynthetic process|calcium ion binding|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cell migration involved in sprouting angiogenesis|leukocyte aggregation|neuron fate commitment|regulation of endothelial cell proliferation|endothelial tube morphogenesis|ventricular trabecula myocardium morphogenesis|dorsal/ventral pattern formation|aorta morphogenesis|negative regulation of endothelial cell proliferation|epithelial cell migration|aorta development|ventricular cardiac muscle tissue development|negative regulation of sprouting angiogenesis|cardiac muscle tissue morphogenesis|Notch signaling pathway|spinal cord patterning|striated muscle tissue development|neurogenesis|ventricular cardiac muscle tissue morphogenesis|regulation of neurogenesis|ventral spinal cord interneuron fate commitment|transcription, DNA-templated|regulation of transcription, DNA-templated|spinal cord dorsal/ventral patterning|transcription from RNA polymerase II promoter|dorsal aorta morphogenesis|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis|cellular response to vascular endothelial growth factor stimulus|dorsal aorta development|regulation of cell migration involved in sprouting angiogenesis|negative regulation of transcription from RNA polymerase II promoter|visual perception|endothelial cell migration|lymphocyte aggregation|blood vessel endothelial cell migration K06051 delta[-] hsa04330 Notch signaling pathway - Homo sapiens (human) 15:40929340-40939072 54 65 102 18 18 18 0.667565743105139 0.730287497343129 1.13686841289821 0.199369316447218 0.182571325712492 0.208543245421134 0.844907217782159 0.196827962526948 2.10185772980363 1.21448446490046e-09 2.63688867019188e-08 UP ENSG00000104142 VPS18 VPS18, CORVET/HOPS core subunit [Source:HGNC Symbol;Acc:HGNC:15972] GO:0040011|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0060090|GO:0043229|GO:0043167|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0016032|GO:0030119|GO:0006810|GO:0005884|GO:0031982|GO:0030117|GO:0043231|GO:0043169|GO:0005774|GO:0005737|GO:0033263|GO:0045184|GO:0030674|GO:0000149|GO:0008104|GO:0051649|GO:0008092|GO:0010008|GO:0030897|GO:0010256|GO:0005768|GO:0006996|GO:0051701|GO:0016192|GO:0046872|GO:0031410|GO:0005769|GO:0003779|GO:0015031|GO:0005773|GO:0016023|GO:0046907|GO:0005770|GO:0031988|GO:0034613|GO:0019058|GO:0030123|GO:0019905|GO:0007032|GO:0005856|GO:0031902|GO:0007033|GO:0015629|GO:0000323|GO:0046718|GO:0006886|GO:0005776|GO:0030135|GO:0016197|GO:0030260|GO:0007034|GO:0005765|GO:0030136|GO:0008333|GO:0007041|GO:0005764|GO:0007040 locomotion|macromolecular complex|cell|membrane|cellular process|binding|binding, bridging|intracellular organelle|ion binding|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|viral process|AP-type membrane coat adaptor complex|transport|actin filament|vesicle|membrane coat|intracellular membrane-bounded organelle|cation binding|vacuolar membrane|cytoplasm|CORVET complex|establishment of protein localization|protein binding, bridging|SNARE binding|protein localization|establishment of localization in cell|cytoskeletal protein binding|endosome membrane|HOPS complex|endomembrane system organization|endosome|organelle organization|interaction with host|vesicle-mediated transport|metal ion binding|cytoplasmic vesicle|early endosome|actin binding|protein transport|vacuole|cytoplasmic, membrane-bounded vesicle|intracellular transport|late endosome|membrane-bounded vesicle|cellular protein localization|viral life cycle|AP-3 adaptor complex|syntaxin binding|endosome organization|cytoskeleton|late endosome membrane|vacuole organization|actin cytoskeleton|lytic vacuole|viral entry into host cell|intracellular protein transport|autophagosome|coated vesicle|endosomal transport|entry into host cell|vacuolar transport|lysosomal membrane|clathrin-coated vesicle|endosome to lysosome transport|lysosomal transport|lysosome|lysosome organization - - - - 15:40894430-40903975 667 690 539 248 299 246 8.818973126769 8.291270894182 6.42532129410339 2.93793243005582 3.24362755022598 3.0482875418094 7.84518843835146 3.07661584069707 1.35046378668369 1.2224065559376e-09 2.65216027041869e-08 UP ENSG00000130821 SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 [Source:HGNC Symbol;Acc:HGNC:11055] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0022857|GO:0005326|GO:0006807|GO:0071704|GO:0044237|GO:0071944|GO:0031224|GO:0005886|GO:0006575|GO:0006810|GO:0006082|GO:0034641|GO:0044281|GO:0005308|GO:0005887|GO:0006520|GO:0003012|GO:0022891|GO:0005328|GO:0031226|GO:0055085|GO:0016021|GO:0006836|GO:0006936|GO:0009308|GO:1903825|GO:0006811|GO:0015075|GO:0005309|GO:0006600|GO:0034220|GO:0006820|GO:0015711|GO:0098656|GO:0015293|GO:0008509|GO:0006812|GO:0046942|GO:0006576|GO:0046943|GO:0019752|GO:0006865|GO:0005343|GO:0008324|GO:0015881|GO:0015171|GO:0003333|GO:0022890|GO:0030001|GO:0008514|GO:0015672|GO:0006595|GO:1902598|GO:0006814|GO:0015077|GO:0046873|GO:0015081 transporter activity|cell|membrane|cellular process|metabolic process|transmembrane transporter activity|neurotransmitter transporter activity|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell periphery|intrinsic component of membrane|plasma membrane|cellular modified amino acid metabolic process|transport|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|creatine transmembrane transporter activity|integral component of plasma membrane|cellular amino acid metabolic process|muscle system process|substrate-specific transmembrane transporter activity|neurotransmitter:sodium symporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|neurotransmitter transport|muscle contraction|amine metabolic process|organic acid transmembrane transport|ion transport|ion transmembrane transporter activity|creatine:sodium symporter activity|creatine metabolic process|ion transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|symporter activity|anion transmembrane transporter activity|cation transport|carboxylic acid transport|cellular biogenic amine metabolic process|carboxylic acid transmembrane transporter activity|carboxylic acid metabolic process|amino acid transport|organic acid:sodium symporter activity|cation transmembrane transporter activity|creatine transport|amino acid transmembrane transporter activity|amino acid transmembrane transport|inorganic cation transmembrane transporter activity|metal ion transport|organic anion transmembrane transporter activity|monovalent inorganic cation transport|polyamine metabolic process|creatine transmembrane transport|sodium ion transport|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|sodium ion transmembrane transporter activity - - - - X:153688099-153696593 506 509 614 236 230 258 4.32176278380753 3.95101028530599 4.72817226523497 1.80600920906987 1.61178318411696 2.06518205867705 4.33364844478283 1.82765815062129 1.24558587290769 1.25986730143834e-09 2.73145086544227e-08 UP ENSG00000116396 KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 [Source:HGNC Symbol;Acc:HGNC:6236] GO:0032991|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0022857|GO:0031594|GO:0050794|GO:0051641|GO:0023051|GO:0016043|GO:0071944|GO:0031224|GO:0007269|GO:0005515|GO:0005886|GO:0043234|GO:0060341|GO:0050804|GO:0006810|GO:0098797|GO:0032940|GO:0022607|GO:0005887|GO:0007267|GO:0043005|GO:0022891|GO:0010646|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0051649|GO:0044306|GO:0001505|GO:0071804|GO:0016021|GO:0046928|GO:0006836|GO:0030424|GO:0015267|GO:0006811|GO:0043679|GO:0015075|GO:0008076|GO:0051046|GO:0034765|GO:0034702|GO:0006461|GO:0043269|GO:0046903|GO:0071805|GO:0034220|GO:0098655|GO:0005216|GO:0051259|GO:0034703|GO:0006812|GO:0008324|GO:0005244|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:0051260|GO:0015672|GO:0007268|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249|GO:0005251 macromolecular complex|transporter activity|synapse|signaling|cell|membrane|cellular process|binding|cell projection|transmembrane transporter activity|neuromuscular junction|regulation of cellular process|cellular localization|regulation of signaling|cellular component organization|cell periphery|intrinsic component of membrane|neurotransmitter secretion|protein binding|plasma membrane|protein complex|regulation of cellular localization|modulation of synaptic transmission|transport|plasma membrane protein complex|secretion by cell|cellular component assembly|integral component of plasma membrane|cell-cell signaling|neuron projection|substrate-specific transmembrane transporter activity|regulation of cell communication|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|establishment of localization in cell|neuron projection terminus|regulation of neurotransmitter levels|cellular potassium ion transport|integral component of membrane|regulation of neurotransmitter secretion|neurotransmitter transport|axon|channel activity|ion transport|axon terminus|ion transmembrane transporter activity|voltage-gated potassium channel complex|regulation of secretion|regulation of ion transmembrane transport|ion channel complex|protein complex assembly|regulation of ion transport|secretion|potassium ion transmembrane transport|ion transmembrane transport|cation transmembrane transport|ion channel activity|protein oligomerization|cation channel complex|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|protein homooligomerization|monovalent inorganic cation transport|synaptic transmission|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity|delayed rectifier potassium channel activity - - - - 1:110211343-110283100 33 45 63 168 239 566 0.0741402880328027 0.0918837229860568 0.127613693926071 0.338180039024169 0.440562963116408 1.19175659857282 0.0978792349816435 0.656833200237799 -2.74645232075133 1.26567554763412e-09 2.74205208991792e-08 DOWN ENSG00000177410 ZFAS1 ZNFX1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:33101] - - - - - - 20:49278178-49295738 3623 3550 3350 1734 1689 1606 88.8933723210299 79.1606752089058 74.1071571542248 38.119555866789 34.0015536066417 36.9296931179992 80.7204015613868 36.3502675304766 1.15096736934375 1.2774354656733e-09 2.76552272604865e-08 UP ENSG00000145536 ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif 16 [Source:HGNC Symbol;Acc:HGNC:17108] GO:0032502|GO:0031012|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0005578|GO:0071704|GO:0043167|GO:0009653|GO:0016043|GO:0016787|GO:0050793|GO:0048856|GO:0048646|GO:0035239|GO:0001822|GO:0009888|GO:1902115|GO:0035295|GO:0007275|GO:0048513|GO:0072028|GO:0051128|GO:0022607|GO:0043169|GO:0008233|GO:0001763|GO:0009887|GO:0048729|GO:0072006|GO:0060491|GO:0008217|GO:0030030|GO:0048869|GO:0019538|GO:0003013|GO:0006996|GO:0000902|GO:0031344|GO:0046872|GO:0002009|GO:0072164|GO:0001655|GO:0048754|GO:0061138|GO:1902017|GO:0044782|GO:0072001|GO:0030031|GO:0006508|GO:0022604|GO:0061326|GO:0070925|GO:0060993|GO:0060429|GO:0042384|GO:0072073|GO:0033043|GO:0032990|GO:0060562|GO:0048858|GO:0001823|GO:0008015|GO:0003073|GO:0008237|GO:0060271|GO:0001657|GO:0072078|GO:0072163|GO:0001658|GO:0061333|GO:0004175|GO:0072080|GO:0046914|GO:0060675|GO:0008270|GO:0004222 developmental process|extracellular matrix|cellular process|extracellular region|metabolic process|binding|catalytic activity|regulation of cellular process|proteinaceous extracellular matrix|organic substance metabolic process|ion binding|anatomical structure morphogenesis|cellular component organization|hydrolase activity|regulation of developmental process|anatomical structure development|anatomical structure formation involved in morphogenesis|tube morphogenesis|kidney development|tissue development|regulation of organelle assembly|tube development|multicellular organism development|animal organ development|nephron morphogenesis|regulation of cellular component organization|cellular component assembly|cation binding|peptidase activity|morphogenesis of a branching structure|organ morphogenesis|tissue morphogenesis|nephron development|regulation of cell projection assembly|regulation of blood pressure|cell projection organization|cellular developmental process|protein metabolic process|circulatory system process|organelle organization|cell morphogenesis|regulation of cell projection organization|metal ion binding|morphogenesis of an epithelium|mesonephric tubule development|urogenital system development|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|regulation of cilium assembly|cilium organization|renal system development|cell projection assembly|proteolysis|regulation of cell morphogenesis|renal tubule development|organelle assembly|kidney morphogenesis|epithelium development|cilium assembly|kidney epithelium development|regulation of organelle organization|cell part morphogenesis|epithelial tube morphogenesis|cell projection morphogenesis|mesonephros development|blood circulation|regulation of systemic arterial blood pressure|metallopeptidase activity|cilium morphogenesis|ureteric bud development|nephron tubule morphogenesis|mesonephric epithelium development|branching involved in ureteric bud morphogenesis|renal tubule morphogenesis|endopeptidase activity|nephron tubule development|transition metal ion binding|ureteric bud morphogenesis|zinc ion binding|metalloendopeptidase activity - - - - 5:5140330-5320304 39 32 63 224 300 136 0.430174387400871 0.320784916034652 0.626526922386144 2.21376300583918 2.7150273852009 1.40589266168347 0.459162075273889 2.11156101757452 -2.20123454524735 1.28992890306104e-09 2.79054619362205e-08 DOWN ENSG00000172869 DMXL1 Dmx-like 1 [Source:HGNC Symbol;Acc:HGNC:2937] GO:0005488|GO:0005515 binding|protein binding - - - - 5:119037772-119249138 234 303 472 935 915 1064 0.770490567483936 0.906720800382438 1.40122141052013 2.75841723519578 2.4719496954268 3.28338305601837 1.02614425946217 2.83791666221365 -1.46759865903992 1.29530552530186e-09 2.80014852660113e-08 DOWN ENSG00000148057 IDNK idnK, gluconokinase homolog (E. coli) [Source:HGNC Symbol;Acc:HGNC:31367] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016740|GO:0044262|GO:0006082|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0005975|GO:0000166|GO:0035639|GO:0001883|GO:0044275|GO:0032549|GO:0016052|GO:0016301|GO:0006796|GO:0017076|GO:0016773|GO:0005524|GO:0046395|GO:0030554|GO:0016310|GO:0046316|GO:0019521|GO:0019752|GO:0046177|GO:0032787 cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|transferase activity|cellular carbohydrate metabolic process|organic acid metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|carbohydrate metabolic process|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|cellular carbohydrate catabolic process|ribonucleoside binding|carbohydrate catabolic process|kinase activity|phosphate-containing compound metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|carboxylic acid catabolic process|adenyl nucleotide binding|phosphorylation|gluconokinase activity|D-gluconate metabolic process|carboxylic acid metabolic process|D-gluconate catabolic process|monocarboxylic acid metabolic process K00851 gluconokinase[2.7.1.12] hsa01100|hsa01200|hsa00030 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Pentose phosphate pathway - Homo sapiens (human) 9:83623049-83644130 10 15 9 64 67 56 0.162980559788399 0.222198146507814 0.132250943270404 0.93461897014132 0.895979430652661 0.855413677051849 0.172476549855539 0.895337359281943 -2.3760311616683 1.34196756598764e-09 2.8989218317652e-08 DOWN ENSG00000167165 UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 [Source:HGNC Symbol;Acc:HGNC:12538] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0042802|GO:0044262|GO:0044255|GO:0006082|GO:0009410|GO:0044281|GO:0031982|GO:0043231|GO:0019899|GO:0005737|GO:0005975|GO:0046983|GO:0044092|GO:0009812|GO:0006629|GO:0005783|GO:0070062|GO:0016757|GO:0042180|GO:0006805|GO:0050790|GO:0045833|GO:0043086|GO:0016021|GO:0031324|GO:0031323|GO:0006109|GO:0046982|GO:0008194|GO:0006631|GO:0052696|GO:0052697|GO:0016758|GO:0071466|GO:0005996|GO:0010565|GO:0009813|GO:0019216|GO:0045922|GO:0042803|GO:0019217|GO:2001030|GO:0015020|GO:1904224|GO:0019752|GO:0032787|GO:0052695 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|identical protein binding|cellular carbohydrate metabolic process|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|carbohydrate metabolic process|protein dimerization activity|negative regulation of molecular function|flavonoid metabolic process|lipid metabolic process|endoplasmic reticulum|extracellular exosome|transferase activity, transferring glycosyl groups|cellular ketone metabolic process|xenobiotic metabolic process|regulation of catalytic activity|negative regulation of lipid metabolic process|negative regulation of catalytic activity|integral component of membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of carbohydrate metabolic process|protein heterodimerization activity|UDP-glycosyltransferase activity|fatty acid metabolic process|flavonoid glucuronidation|xenobiotic glucuronidation|transferase activity, transferring hexosyl groups|cellular response to xenobiotic stimulus|monosaccharide metabolic process|regulation of cellular ketone metabolic process|flavonoid biosynthetic process|regulation of lipid metabolic process|negative regulation of fatty acid metabolic process|protein homodimerization activity|regulation of fatty acid metabolic process|negative regulation of cellular glucuronidation|glucuronosyltransferase activity|negative regulation of glucuronosyltransferase activity|carboxylic acid metabolic process|monocarboxylic acid metabolic process|cellular glucuronidation K00699 glucuronosyltransferase[2.4.1.17] hsa01100|hsa05204|hsa00980|hsa00982|hsa00830|hsa00140|hsa00500|hsa00983|hsa00860|hsa00040|hsa00053 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Ascorbate and aldarate metabolism - Homo sapiens (human) 2:233691607-233773300 1859 1819 2441 4933 5011 5789 17.47505948949 15.540033834567 20.6881311160899 41.5478004602836 38.6484030817469 51.0001784627421 17.9010748133823 43.7321273349242 -1.28864731740312 1.34466285869764e-09 2.90264388890524e-08 DOWN ENSG00000149781 FERMT3 fermitin family member 3 [Source:HGNC Symbol;Acc:HGNC:23151] GO:0040011|GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0051272|GO:0050817|GO:0016337|GO:0048468|GO:0034446|GO:0005102|GO:0030155|GO:0031982|GO:2000147|GO:0022607|GO:0098609|GO:0033627|GO:0009611|GO:0006928|GO:0032403|GO:0001775|GO:0031589|GO:0050839|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0070062|GO:0048869|GO:2000145|GO:0050878|GO:0002102|GO:0000902|GO:0030168|GO:0007166|GO:0007596|GO:0034109|GO:0000904|GO:0030334|GO:0033628|GO:0042060|GO:0005178|GO:0022407|GO:0007599|GO:0007159|GO:0006461|GO:0033631|GO:0030154|GO:0030335|GO:0005856|GO:0015629|GO:0070527|GO:0007229|GO:0033632|GO:0033622 locomotion|developmental process|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|intracellular|protein binding|protein complex|anatomical structure development|positive regulation of cellular component movement|coagulation|single organismal cell-cell adhesion|cell development|substrate adhesion-dependent cell spreading|receptor binding|regulation of cell adhesion|vesicle|positive regulation of cell motility|cellular component assembly|cell-cell adhesion|cell adhesion mediated by integrin|response to wounding|movement of cell or subcellular component|protein complex binding|cell activation|cell-substrate adhesion|cell adhesion molecule binding|cell communication|regulation of cellular component movement|cell migration|signal transduction|extracellular exosome|cellular developmental process|regulation of cell motility|regulation of body fluid levels|podosome|cell morphogenesis|platelet activation|cell surface receptor signaling pathway|blood coagulation|homotypic cell-cell adhesion|cell morphogenesis involved in differentiation|regulation of cell migration|regulation of cell adhesion mediated by integrin|wound healing|integrin binding|regulation of cell-cell adhesion|hemostasis|leukocyte cell-cell adhesion|protein complex assembly|cell-cell adhesion mediated by integrin|cell differentiation|positive regulation of cell migration|cytoskeleton|actin cytoskeleton|platelet aggregation|integrin-mediated signaling pathway|regulation of cell-cell adhesion mediated by integrin|integrin activation K17084 kindlin 3[-] hsa04611 Platelet activation - Homo sapiens (human) 11:64206678-64223886 183 156 62 17 28 19 2.10041724785474 1.62726255465436 0.641587818771501 0.174824344509195 0.263682121722322 0.204376147278508 1.45642254042687 0.214294204503342 2.76476423546619 1.36450989996178e-09 2.94335827698402e-08 UP ENSG00000134755 DSC2 desmocollin 2 [Source:HGNC Symbol;Acc:HGNC:3036] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0098900|GO:0050794|GO:0006950|GO:0043167|GO:0005911|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0016337|GO:0042391|GO:0009991|GO:0044291|GO:0005912|GO:0031982|GO:0033554|GO:0098609|GO:0043169|GO:0005737|GO:0032970|GO:0003012|GO:0031668|GO:0006928|GO:0098901|GO:0007154|GO:0051270|GO:0005913|GO:0070062|GO:0030057|GO:0002027|GO:0016021|GO:0030029|GO:0003013|GO:0042594|GO:0098742|GO:0006936|GO:0046872|GO:0061337|GO:0031410|GO:0030048|GO:0034109|GO:0014704|GO:0090257|GO:0001508|GO:0086091|GO:0098632|GO:0009267|GO:0034113|GO:0031669|GO:0031667|GO:0008015|GO:0098911|GO:0086065|GO:0006941|GO:0008016|GO:0086080|GO:0070252|GO:0086001|GO:0086073|GO:0006937|GO:0060047|GO:0086069|GO:0005509|GO:0086004|GO:0007156|GO:0086042|GO:0086003|GO:0006942|GO:0086002|GO:0060048|GO:0055117|GO:0086083|GO:0086005 signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of action potential|regulation of cellular process|response to stress|ion binding|cell-cell junction|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|intrinsic component of membrane|intracellular|protein binding|plasma membrane|single organismal cell-cell adhesion|regulation of membrane potential|response to extracellular stimulus|cell-cell contact zone|adherens junction|vesicle|cellular response to stress|cell-cell adhesion|cation binding|cytoplasm|regulation of actin filament-based process|muscle system process|cellular response to extracellular stimulus|movement of cell or subcellular component|regulation of cardiac muscle cell action potential|cell communication|regulation of cellular component movement|cell-cell adherens junction|extracellular exosome|desmosome|regulation of heart rate|integral component of membrane|actin filament-based process|circulatory system process|response to starvation|cell-cell adhesion via plasma-membrane adhesion molecules|muscle contraction|metal ion binding|cardiac conduction|cytoplasmic vesicle|actin filament-based movement|homotypic cell-cell adhesion|intercalated disc|regulation of muscle system process|action potential|regulation of heart rate by cardiac conduction|protein binding involved in cell-cell adhesion|cellular response to starvation|heterotypic cell-cell adhesion|cellular response to nutrient levels|response to nutrient levels|blood circulation|regulation of ventricular cardiac muscle cell action potential|cell communication involved in cardiac conduction|striated muscle contraction|regulation of heart contraction|protein binding involved in heterotypic cell-cell adhesion|actin-mediated cell contraction|cardiac muscle cell action potential|bundle of His cell-Purkinje myocyte adhesion involved in cell communication|regulation of muscle contraction|heart contraction|bundle of His cell to Purkinje myocyte communication|calcium ion binding|regulation of cardiac muscle cell contraction|homophilic cell adhesion via plasma membrane adhesion molecules|cardiac muscle cell-cardiac muscle cell adhesion|cardiac muscle cell contraction|regulation of striated muscle contraction|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|regulation of cardiac muscle contraction|cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication|ventricular cardiac muscle cell action potential K07601 desmocollin 2[-] hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 18:31058840-31102415 1524 1585 1543 712 859 598 7.32755476924414 6.92601454041697 6.68889100185631 3.06726673592831 3.38871721015861 2.69466302509203 6.98082010383914 3.05021565705965 1.19448528556081 1.3730618765769e-09 2.95966709482503e-08 UP ENSG00000169604 ANTXR1 anthrax toxin receptor 1 [Source:HGNC Symbol;Acc:HGNC:21014] GO:0032502|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0004872|GO:0044877|GO:0050794|GO:0043229|GO:0043167|GO:0009986|GO:0038023|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031252|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0048468|GO:0034446|GO:0031982|GO:0043231|GO:0043169|GO:0004888|GO:0005737|GO:0032403|GO:0031589|GO:0030027|GO:0007154|GO:0007165|GO:0070062|GO:0008092|GO:0031256|GO:0010008|GO:0031253|GO:0048869|GO:0016021|GO:0030029|GO:0005768|GO:0006996|GO:0000902|GO:0046872|GO:0031258|GO:0007010|GO:0003779|GO:0005518|GO:0000904|GO:0030175|GO:0030036|GO:0031527|GO:0051015|GO:0030154|GO:0031532 developmental process|signal transducer activity|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|receptor activity|macromolecular complex binding|regulation of cellular process|intracellular organelle|ion binding|cell surface|signaling receptor activity|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|cell leading edge|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|cell development|substrate adhesion-dependent cell spreading|vesicle|intracellular membrane-bounded organelle|cation binding|transmembrane signaling receptor activity|cytoplasm|protein complex binding|cell-substrate adhesion|lamellipodium|cell communication|signal transduction|extracellular exosome|cytoskeletal protein binding|leading edge membrane|endosome membrane|cell projection membrane|cellular developmental process|integral component of membrane|actin filament-based process|endosome|organelle organization|cell morphogenesis|metal ion binding|lamellipodium membrane|cytoskeleton organization|actin binding|collagen binding|cell morphogenesis involved in differentiation|filopodium|actin cytoskeleton organization|filopodium membrane|actin filament binding|cell differentiation|actin cytoskeleton reorganization - - - - 2:69013178-69249327 18 26 49 129 134 173 0.132260350474277 0.17362312808308 0.324610410855755 0.849261603233351 0.807842677684128 1.19132069028288 0.210164629804371 0.94947499040012 -2.17561011197096 1.37721873780532e-09 2.96648544000288e-08 DOWN ENSG00000117983 MUC5B mucin 5B, oligomeric mucus/gel-forming [Source:HGNC Symbol;Acc:HGNC:7516] GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0050794|GO:0045321|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0005615|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0006486|GO:0006952|GO:0031982|GO:0098542|GO:0043231|GO:0005737|GO:0005975|GO:0001775|GO:0009617|GO:0050865|GO:0070062|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0043412|GO:0006493|GO:0009100|GO:0036211|GO:0005796|GO:0070085|GO:0042116|GO:0043030|GO:1901137|GO:0044267|GO:0042742|GO:0009059|GO:0009101|GO:0043413|GO:0006464|GO:0016266|GO:0043687 immune system process|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|regulation of cellular process|leukocyte activation|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|extracellular space|intracellular|regulation of immune system process|protein binding|endomembrane system|protein glycosylation|defense response|vesicle|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|cell activation|response to bacterium|regulation of cell activation|extracellular exosome|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|macromolecule modification|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|Golgi lumen|glycosylation|macrophage activation|regulation of macrophage activation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|defense response to bacterium|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|cellular protein modification process|O-glycan processing|post-translational protein modification K13908 mucin-5B[-] hsa04970 Salivary secretion - Homo sapiens (human) 11:1223066-1262172 259 320 597 1171 1376 2864 0.947645014505559 1.06408403586108 1.96940615480829 3.83884786288872 4.13078855822436 9.82083532940674 1.32704506839164 5.93015725017327 -2.15985299369598 1.41048462146621e-09 3.03594865820131e-08 DOWN ENSG00000136826 KLF4 Kruppel-like factor 4 (gut) [Source:HGNC Symbol;Acc:HGNC:6348] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0040013|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0000989|GO:0009653|GO:0000785|GO:0016043|GO:0007155|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0030234|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0001818|GO:1903409|GO:0042127|GO:0044255|GO:0016337|GO:0000791|GO:0009791|GO:0048569|GO:0045595|GO:0006725|GO:0009888|GO:0008013|GO:0048468|GO:1901360|GO:0001568|GO:0010941|GO:0034405|GO:0007275|GO:0010632|GO:0003676|GO:0048513|GO:0034641|GO:0006952|GO:0030155|GO:2001057|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0060761|GO:0001817|GO:0098609|GO:0051098|GO:0042228|GO:0043231|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0000981|GO:0003012|GO:0001816|GO:0009611|GO:0001076|GO:0007423|GO:0006928|GO:0005667|GO:0072593|GO:0009966|GO:0048729|GO:0048598|GO:0009890|GO:0006979|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0007162|GO:0001525|GO:0000790|GO:0007154|GO:0001704|GO:0044092|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0009968|GO:0008134|GO:0008219|GO:0051271|GO:0008285|GO:0050790|GO:0030030|GO:0019207|GO:0043086|GO:0001010|GO:0048869|GO:2000145|GO:0010035|GO:0044249|GO:0010633|GO:0019827|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:2000146|GO:0051090|GO:0016525|GO:0042107|GO:0070570|GO:0000165|GO:0014740|GO:0000982|GO:0032268|GO:0031175|GO:0003677|GO:0098742|GO:0031344|GO:0002040|GO:0071498|GO:0042036|GO:0010468|GO:0090132|GO:0034645|GO:0048660|GO:0042089|GO:0051101|GO:0046872|GO:0007166|GO:0001654|GO:0002009|GO:0033993|GO:0031102|GO:0044798|GO:0001944|GO:0043412|GO:0035166|GO:0030097|GO:0072358|GO:0034097|GO:0001085|GO:0042542|GO:0010629|GO:0050727|GO:0032642|GO:0007498|GO:0043069|GO:0048678|GO:0051252|GO:0060795|GO:1901652|GO:0001709|GO:0048659|GO:0009790|GO:0090257|GO:0070586|GO:0071417|GO:0010628|GO:0030334|GO:0020027|GO:0001667|GO:0051347|GO:0036211|GO:0032269|GO:2000377|GO:0035014|GO:0007369|GO:0006954|GO:0046209|GO:0032602|GO:1903428|GO:0032717|GO:0022408|GO:0022407|GO:0001707|GO:0031981|GO:0046898|GO:0045765|GO:0050728|GO:0034599|GO:0042035|GO:0042826|GO:0051099|GO:0051247|GO:0051346|GO:0070848|GO:0006508|GO:0045428|GO:0005654|GO:0006259|GO:0043433|GO:0005694|GO:0000228|GO:0035019|GO:0048679|GO:0030336|GO:0001221|GO:0034616|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0000302|GO:0051054|GO:0006796|GO:0034113|GO:1901342|GO:0032526|GO:0035556|GO:0031077|GO:0044267|GO:0051174|GO:0010467|GO:0007399|GO:0019216|GO:0071310|GO:1902532|GO:0010594|GO:0031328|GO:0006809|GO:0051246|GO:0010470|GO:0009059|GO:0030154|GO:0001228|GO:0005719|GO:0001191|GO:1902531|GO:0016070|GO:0072359|GO:0010557|GO:0010596|GO:0045414|GO:0005634|GO:0043067|GO:0048662|GO:0045415|GO:0006644|GO:0097305|GO:0048332|GO:1903426|GO:0051960|GO:0032682|GO:0045165|GO:0045995|GO:0032637|GO:2000379|GO:0048666|GO:0030182|GO:0051896|GO:0016055|GO:0043491|GO:0010466|GO:0000975|GO:0045893|GO:0007500|GO:0010975|GO:0045444|GO:0046984|GO:0051898|GO:0006260|GO:2000677|GO:0042541|GO:0030855|GO:1901653|GO:0043408|GO:0045892|GO:0043010|GO:2000342|GO:0051972|GO:0032774|GO:0043565|GO:0043550|GO:0048333|GO:0030162|GO:2001141|GO:0034115|GO:0001077|GO:0071363|GO:0051973|GO:2000341|GO:0043537|GO:0043535|GO:0016310|GO:1902679|GO:0052547|GO:0070371|GO:0043388|GO:0008544|GO:0071409|GO:0071407|GO:0002042|GO:0003690|GO:0061564|GO:0048017|GO:2000278|GO:0046985|GO:0006275|GO:0048730|GO:0010631|GO:0014067|GO:0042981|GO:0032088|GO:0045429|GO:0045861|GO:0046914|GO:1903725|GO:0043066|GO:0043409|GO:1903671|GO:0001710|GO:2000573|GO:0014066|GO:0071300|GO:0045740|GO:0034614|GO:0022008|GO:0006464|GO:0031103|GO:0050767|GO:0071396|GO:0071897|GO:0043549|GO:0006351|GO:0071499|GO:0070301|GO:0006915|GO:0006355|GO:0043551|GO:0045944|GO:0006366|GO:1903507|GO:0048015|GO:0006357|GO:0043281|GO:0006468|GO:0048699|GO:1903506|GO:0044212|GO:0060070|GO:0090051|GO:0001190|GO:0042325|GO:2000679|GO:0001932|GO:0010951|GO:0042326|GO:0090049|GO:0001933|GO:0000122|GO:0070372|GO:0043154|GO:0043542|GO:0070373|GO:0008270|GO:0045664|GO:0052548|GO:0009913|GO:2000117|GO:0001047|GO:0000976|GO:0014065|GO:2000116|GO:0001159|GO:0043534|GO:0000987 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|negative regulation of locomotion|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cellular component organization|cell adhesion|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|regulation of developmental process|intracellular|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|negative regulation of cytokine production|reactive oxygen species biosynthetic process|regulation of cell proliferation|cellular lipid metabolic process|single organismal cell-cell adhesion|euchromatin|post-embryonic development|post-embryonic organ development|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|beta-catenin binding|cell development|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to fluid shear stress|multicellular organism development|regulation of epithelial cell migration|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|defense response|regulation of cell adhesion|reactive nitrogen species metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|negative regulation of response to cytokine stimulus|regulation of cytokine production|cell-cell adhesion|regulation of binding|interleukin-8 biosynthetic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|muscle system process|cytokine production|response to wounding|transcription factor activity, RNA polymerase II transcription factor binding|sensory organ development|movement of cell or subcellular component|transcription factor complex|reactive oxygen species metabolic process|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|negative regulation of biosynthetic process|response to oxidative stress|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|negative regulation of cell adhesion|angiogenesis|nuclear chromatin|cell communication|formation of primary germ layer|negative regulation of molecular function|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|negative regulation of signal transduction|transcription factor binding|cell death|negative regulation of cellular component movement|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|kinase regulator activity|negative regulation of catalytic activity|transcription factor activity, sequence-specific DNA binding transcription factor recruiting|cellular developmental process|regulation of cell motility|response to inorganic substance|cellular biosynthetic process|negative regulation of epithelial cell migration|stem cell population maintenance|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|regulation of sequence-specific DNA binding transcription factor activity|negative regulation of angiogenesis|cytokine metabolic process|regulation of neuron projection regeneration|MAPK cascade|negative regulation of muscle hyperplasia|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of cellular protein metabolic process|neuron projection development|DNA binding|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of cell projection organization|sprouting angiogenesis|cellular response to fluid shear stress|negative regulation of cytokine biosynthetic process|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|cytokine biosynthetic process|regulation of DNA binding|metal ion binding|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|response to lipid|neuron projection regeneration|nuclear transcription factor complex|vasculature development|macromolecule modification|post-embryonic hemopoiesis|hemopoiesis|cardiovascular system development|response to cytokine|RNA polymerase II transcription factor binding|response to hydrogen peroxide|negative regulation of gene expression|regulation of inflammatory response|regulation of chemokine production|mesoderm development|negative regulation of programmed cell death|response to axon injury|regulation of RNA metabolic process|cell fate commitment involved in formation of primary germ layer|response to peptide|cell fate determination|smooth muscle cell proliferation|embryo development|regulation of muscle system process|cell-cell adhesion involved in gastrulation|cellular response to organonitrogen compound|positive regulation of gene expression|regulation of cell migration|hemoglobin metabolic process|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of reactive oxygen species metabolic process|phosphatidylinositol 3-kinase regulator activity|gastrulation|inflammatory response|nitric oxide metabolic process|chemokine production|positive regulation of reactive oxygen species biosynthetic process|negative regulation of interleukin-8 production|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|mesoderm formation|nuclear lumen|response to cycloheximide|regulation of angiogenesis|negative regulation of inflammatory response|cellular response to oxidative stress|regulation of cytokine biosynthetic process|histone deacetylase binding|positive regulation of binding|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|proteolysis|regulation of nitric oxide biosynthetic process|nucleoplasm|DNA metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|chromosome|nuclear chromosome|somatic stem cell population maintenance|regulation of axon regeneration|negative regulation of cell migration|transcription cofactor binding|response to laminar fluid shear stress|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|response to reactive oxygen species|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|heterotypic cell-cell adhesion|regulation of vasculature development|response to retinoic acid|intracellular signal transduction|post-embryonic camera-type eye development|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|nervous system development|regulation of lipid metabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of endothelial cell migration|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|regulation of gastrulation|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|nuclear euchromatin|transcriptional repressor activity, RNA polymerase II transcription factor binding|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|negative regulation of endothelial cell migration|regulation of interleukin-8 biosynthetic process|nucleus|regulation of programmed cell death|negative regulation of smooth muscle cell proliferation|negative regulation of interleukin-8 biosynthetic process|phospholipid metabolic process|response to alcohol|mesoderm morphogenesis|regulation of reactive oxygen species biosynthetic process|regulation of nervous system development|negative regulation of chemokine production|cell fate commitment|regulation of embryonic development|interleukin-8 production|positive regulation of reactive oxygen species metabolic process|neuron development|neuron differentiation|regulation of protein kinase B signaling|Wnt signaling pathway|protein kinase B signaling|negative regulation of peptidase activity|regulatory region DNA binding|positive regulation of transcription, DNA-templated|mesodermal cell fate determination|regulation of neuron projection development|fat cell differentiation|regulation of hemoglobin biosynthetic process|negative regulation of protein kinase B signaling|DNA replication|regulation of transcription regulatory region DNA binding|hemoglobin biosynthetic process|epithelial cell differentiation|cellular response to peptide|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|camera-type eye development|negative regulation of chemokine (C-X-C motif) ligand 2 production|regulation of telomerase activity|RNA biosynthetic process|sequence-specific DNA binding|regulation of lipid kinase activity|mesodermal cell differentiation|regulation of proteolysis|regulation of RNA biosynthetic process|negative regulation of heterotypic cell-cell adhesion|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cellular response to growth factor stimulus|positive regulation of telomerase activity|regulation of chemokine (C-X-C motif) ligand 2 production|negative regulation of blood vessel endothelial cell migration|regulation of blood vessel endothelial cell migration|phosphorylation|negative regulation of RNA biosynthetic process|regulation of peptidase activity|ERK1 and ERK2 cascade|positive regulation of DNA binding|epidermis development|cellular response to cycloheximide|cellular response to organic cyclic compound|cell migration involved in sprouting angiogenesis|double-stranded DNA binding|axon development|inositol lipid-mediated signaling|regulation of DNA biosynthetic process|positive regulation of hemoglobin biosynthetic process|regulation of DNA replication|epidermis morphogenesis|epithelial cell migration|negative regulation of phosphatidylinositol 3-kinase signaling|regulation of apoptotic process|negative regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|negative regulation of proteolysis|transition metal ion binding|regulation of phospholipid metabolic process|negative regulation of apoptotic process|negative regulation of MAPK cascade|negative regulation of sprouting angiogenesis|mesodermal cell fate commitment|positive regulation of DNA biosynthetic process|regulation of phosphatidylinositol 3-kinase signaling|cellular response to retinoic acid|positive regulation of DNA replication|cellular response to reactive oxygen species|neurogenesis|cellular protein modification process|axon regeneration|regulation of neurogenesis|cellular response to lipid|DNA biosynthetic process|regulation of kinase activity|transcription, DNA-templated|cellular response to laminar fluid shear stress|cellular response to hydrogen peroxide|apoptotic process|regulation of transcription, DNA-templated|regulation of phosphatidylinositol 3-kinase activity|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|canonical Wnt signaling pathway|negative regulation of cell migration involved in sprouting angiogenesis|transcriptional activator activity, RNA polymerase II transcription factor binding|regulation of phosphorylation|positive regulation of transcription regulatory region DNA binding|regulation of protein phosphorylation|negative regulation of endopeptidase activity|negative regulation of phosphorylation|regulation of cell migration involved in sprouting angiogenesis|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|regulation of ERK1 and ERK2 cascade|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|endothelial cell migration|negative regulation of ERK1 and ERK2 cascade|zinc ion binding|regulation of neuron differentiation|regulation of endopeptidase activity|epidermal cell differentiation|negative regulation of cysteine-type endopeptidase activity|core promoter binding|transcription regulatory region sequence-specific DNA binding|phosphatidylinositol 3-kinase signaling|regulation of cysteine-type endopeptidase activity|core promoter proximal region DNA binding|blood vessel endothelial cell migration|core promoter proximal region sequence-specific DNA binding K17846 krueppel-like factor 4[-] hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) 9:107484852-107490482 776 876 1161 396 527 388 6.14483701161794 6.30423569579991 8.28886332028466 2.80958066669092 3.42394798956072 2.87944844700248 6.9126453425675 3.03765903441804 1.18627796726601 1.42942102064591e-09 3.07449100506937e-08 UP ENSG00000225484 NUTM2B-AS1 NUTM2B antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51204] - - - - - - 10:79663088-79826594 47 63 91 266 232 221 0.202216599412201 0.246343315834757 0.352997741062988 1.02540780545646 0.818980394421048 0.891124819900623 0.267185885436649 0.911837673259377 -1.77093321953765 1.43320604739092e-09 3.08041276737283e-08 DOWN ENSG00000062822 POLD1 polymerase (DNA directed), delta 1, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9175] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0051606|GO:0044877|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0007049|GO:0006281|GO:0006725|GO:0009314|GO:0022402|GO:1901360|GO:0051536|GO:0003676|GO:0034641|GO:0016788|GO:0042769|GO:0044281|GO:0016772|GO:0046483|GO:0033554|GO:0043231|GO:0000723|GO:0043169|GO:0016234|GO:0019899|GO:0005737|GO:0042592|GO:0019725|GO:0003682|GO:0006139|GO:0000166|GO:0044249|GO:1990391|GO:0006996|GO:0051276|GO:0003677|GO:0051539|GO:0034645|GO:0046872|GO:0010833|GO:0019985|GO:0048878|GO:0000722|GO:0006284|GO:0016235|GO:0033260|GO:0000278|GO:0005657|GO:0031981|GO:0004518|GO:0000731|GO:1990234|GO:0071478|GO:0043625|GO:0006298|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0032201|GO:0006301|GO:0009059|GO:0016779|GO:0006289|GO:0005634|GO:0009416|GO:0006974|GO:0045004|GO:0000109|GO:0034061|GO:0032200|GO:0006260|GO:0043596|GO:0000781|GO:0004536|GO:0009411|GO:0006297|GO:0022616|GO:0006283|GO:0004527|GO:0003684|GO:0070911|GO:0071482|GO:0006310|GO:0033683|GO:0050801|GO:0055088|GO:0090305|GO:0071897|GO:0006287|GO:0006271|GO:0006261|GO:0008408|GO:0055081|GO:0055089|GO:0006312|GO:0003887|GO:0034644|GO:0008296 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|detection of stimulus|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|transferase activity|cell cycle|DNA repair|cellular aromatic compound metabolic process|response to radiation|cell cycle process|organic cyclic compound metabolic process|iron-sulfur cluster binding|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|DNA damage response, detection of DNA damage|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|telomere maintenance|cation binding|inclusion body|enzyme binding|cytoplasm|homeostatic process|cellular homeostasis|chromatin binding|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|DNA repair complex|organelle organization|chromosome organization|DNA binding|4 iron, 4 sulfur cluster binding|cellular macromolecule biosynthetic process|metal ion binding|telomere maintenance via telomere lengthening|translesion synthesis|chemical homeostasis|telomere maintenance via recombination|base-excision repair|aggresome|nuclear DNA replication|mitotic cell cycle|replication fork|nuclear lumen|nuclease activity|DNA synthesis involved in DNA repair|transferase complex|cellular response to radiation|delta DNA polymerase complex|mismatch repair|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|telomere maintenance via semi-conservative replication|postreplication repair|macromolecule biosynthetic process|nucleotidyltransferase activity|nucleotide-excision repair|nucleus|response to light stimulus|cellular response to DNA damage stimulus|DNA replication proofreading|nucleotide-excision repair complex|DNA polymerase activity|telomere organization|DNA replication|nuclear replication fork|chromosome, telomeric region|deoxyribonuclease activity|response to UV|nucleotide-excision repair, DNA gap filling|DNA strand elongation|transcription-coupled nucleotide-excision repair|exonuclease activity|damaged DNA binding|global genome nucleotide-excision repair|cellular response to light stimulus|DNA recombination|nucleotide-excision repair, DNA incision|ion homeostasis|lipid homeostasis|nucleic acid phosphodiester bond hydrolysis|DNA biosynthetic process|base-excision repair, gap-filling|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication|3'-5' exonuclease activity|anion homeostasis|fatty acid homeostasis|mitotic recombination|DNA-directed DNA polymerase activity|cellular response to UV|3'-5'-exodeoxyribonuclease activity K02327 DNA polymerase delta subunit 1[2.7.7.7] hsa01100|hsa05166|hsa00230|hsa00240|hsa03420|hsa03030|hsa03410|hsa03440|hsa03430 Metabolic pathways - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Nucleotide excision repair - Homo sapiens (human)|DNA replication - Homo sapiens (human)|Base excision repair - Homo sapiens (human)|Homologous recombination - Homo sapiens (human)|Mismatch repair - Homo sapiens (human) 19:50384204-50418018 290 349 585 1256 1462 950 2.50288688485266 2.7374693570343 4.55212207991071 9.7125009650169 10.3528333673128 7.68415763602699 3.26415944059922 9.2498306561189 -1.50271542464774 1.43568451636327e-09 3.08351982384957e-08 DOWN ENSG00000117118 SDHB succinate dehydrogenase complex subunit B, iron sulfur (Ip) [Source:HGNC Symbol;Acc:HGNC:10681] GO:0009055|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0016491|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0070469|GO:0043227|GO:0048037|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0031090|GO:0048038|GO:0045273|GO:0019866|GO:0005746|GO:0006082|GO:0051536|GO:0015980|GO:0044281|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0031966|GO:0006099|GO:0070062|GO:0016627|GO:0045281|GO:0006091|GO:0022900|GO:0055114|GO:0005740|GO:0051539|GO:0048039|GO:0046872|GO:0000104|GO:0022904|GO:0005743|GO:0031981|GO:0005749|GO:0051538|GO:0005654|GO:0005739|GO:0045333|GO:0051537|GO:0005634|GO:0009060|GO:0008177|GO:0019752|GO:0072350|GO:0043648|GO:0006105|GO:0006101 electron carrier activity|macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|oxidoreductase activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|respiratory chain|membrane-bounded organelle|cofactor binding|cell periphery|intracellular|protein binding|plasma membrane|protein complex|organelle membrane|quinone binding|respiratory chain complex II|organelle inner membrane|mitochondrial respiratory chain|organic acid metabolic process|iron-sulfur cluster binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|mitochondrial membrane|tricarboxylic acid cycle|extracellular exosome|oxidoreductase activity, acting on the CH-CH group of donors|succinate dehydrogenase complex|generation of precursor metabolites and energy|electron transport chain|oxidation-reduction process|mitochondrial envelope|4 iron, 4 sulfur cluster binding|ubiquinone binding|metal ion binding|succinate dehydrogenase activity|respiratory electron transport chain|mitochondrial inner membrane|nuclear lumen|mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)|3 iron, 4 sulfur cluster binding|nucleoplasm|mitochondrion|cellular respiration|2 iron, 2 sulfur cluster binding|nucleus|aerobic respiration|succinate dehydrogenase (ubiquinone) activity|carboxylic acid metabolic process|tricarboxylic acid metabolic process|dicarboxylic acid metabolic process|succinate metabolic process|citrate metabolic process K00235 succinate dehydrogenase (ubiquinone) iron-sulfur subunit[1.3.5.1] hsa01100|hsa05016|hsa05010|hsa04932|hsa05012|hsa00190|hsa01200|hsa00020 Metabolic pathways - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Parkinson,s disease - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Citrate cycle (TCA cycle) - Homo sapiens (human) 1:17018722-17054170 458 607 703 1658 1870 1270 9.70275406771017 11.6868591753977 13.4276137938003 31.4710773047228 32.5041598608861 25.215176442726 11.6057423456361 29.730137869445 -1.35708734788805 1.43708941473159e-09 3.08431828809468e-08 DOWN ENSG00000140262 TCF12 transcription factor 12 [Source:HGNC Symbol;Acc:HGNC:11623] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0006955|GO:0044237|GO:0000785|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042802|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0061061|GO:0045597|GO:0043231|GO:0046332|GO:0005737|GO:0000981|GO:0005667|GO:0046983|GO:0019904|GO:0006139|GO:0000790|GO:0008134|GO:0048869|GO:0044249|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0044798|GO:0010720|GO:0046982|GO:0051252|GO:0071837|GO:0043425|GO:0010628|GO:0031981|GO:0050769|GO:0005694|GO:0000228|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0007517|GO:0016070|GO:0010557|GO:0005634|GO:0042803|GO:0051960|GO:0030182|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0003690|GO:0090575|GO:0022008|GO:0050767|GO:0006351|GO:0006355|GO:0045666|GO:0045944|GO:0006366|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0045664|GO:0035326|GO:0035497|GO:0000976|GO:0001012|GO:0070888|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|immune response|cellular metabolic process|chromatin|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|SMAD binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor complex|protein dimerization activity|protein domain specific binding|nucleobase-containing compound metabolic process|nuclear chromatin|transcription factor binding|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|nuclear transcription factor complex|positive regulation of cell development|protein heterodimerization activity|regulation of RNA metabolic process|HMG box domain binding|bHLH transcription factor binding|positive regulation of gene expression|nuclear lumen|positive regulation of neurogenesis|chromosome|nuclear chromosome|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|muscle organ development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|regulation of nervous system development|neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|RNA polymerase II transcription factor complex|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of neuron differentiation|enhancer binding|cAMP response element binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|E-box binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 15:56918623-57299281 270 341 452 947 908 947 0.78567293547 0.901805933342407 1.18585483856281 2.46902989407187 2.16786725900527 2.58260309962335 0.957777902458406 2.4065000842335 -1.32917341812296 1.44116840477231e-09 3.09085068649947e-08 DOWN ENSG00000114739 ACVR2B activin A receptor type IIB [Source:HGNC Symbol;Acc:HGNC:174] GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0004872|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0006807|GO:0005057|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0023051|GO:0009653|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0001946|GO:0007507|GO:0048565|GO:0009791|GO:0045595|GO:0035239|GO:0006725|GO:0060041|GO:0001822|GO:0009888|GO:0019838|GO:0006810|GO:0035295|GO:1901360|GO:0001568|GO:0007275|GO:0030324|GO:0048513|GO:0001945|GO:0034641|GO:0043168|GO:0032940|GO:0034711|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0070169|GO:0007440|GO:0035265|GO:0005887|GO:0045597|GO:0043169|GO:0004888|GO:0005737|GO:0007389|GO:0007267|GO:0007423|GO:0043235|GO:0009887|GO:0032403|GO:0009966|GO:0048598|GO:0045184|GO:0048771|GO:0009890|GO:0030323|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0008104|GO:0007154|GO:0045778|GO:0007165|GO:0030278|GO:0001503|GO:0004702|GO:0031016|GO:0050790|GO:0000166|GO:0036303|GO:0010817|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0060021|GO:0030501|GO:0032268|GO:0048705|GO:0009743|GO:0010468|GO:0071773|GO:0034645|GO:0055123|GO:0046872|GO:0007166|GO:0001654|GO:0035639|GO:0001944|GO:0043412|GO:0072358|GO:0001655|GO:0010629|GO:0007498|GO:0051252|GO:0060541|GO:0001883|GO:0045667|GO:0015031|GO:0031214|GO:0009790|GO:0051347|GO:0036211|GO:0060840|GO:0007369|GO:0042886|GO:0072001|GO:0032549|GO:0001649|GO:0003002|GO:0009914|GO:0009306|GO:0051247|GO:0070848|GO:0016301|GO:0001974|GO:0045669|GO:0032270|GO:0060429|GO:0006796|GO:0042476|GO:0044267|GO:0051174|GO:0048185|GO:0010467|GO:0060841|GO:0046903|GO:0071310|GO:0017076|GO:0051246|GO:0061298|GO:0009059|GO:0030154|GO:0001501|GO:0048546|GO:0016070|GO:0072359|GO:0016773|GO:0030282|GO:0048617|GO:0060836|GO:0030500|GO:0002790|GO:0003158|GO:0030073|GO:0031401|GO:0032925|GO:0030855|GO:0045892|GO:0043010|GO:0032774|GO:0005524|GO:2001141|GO:0034284|GO:0071363|GO:0030554|GO:0016310|GO:0015833|GO:1902679|GO:0004675|GO:0030509|GO:0007167|GO:0009855|GO:0009952|GO:0001702|GO:0004672|GO:0042475|GO:0006464|GO:0032927|GO:0046879|GO:0043549|GO:0006351|GO:0006355|GO:0033674|GO:0045446|GO:0006366|GO:0030072|GO:0017002|GO:0045859|GO:1903507|GO:0045860|GO:0006357|GO:0006468|GO:0007368|GO:0004712|GO:1903506|GO:0042325|GO:0001932|GO:0004674|GO:0001934|GO:0007178|GO:0000122|GO:0042327|GO:0032924|GO:0009749|GO:0016362|GO:0032147 developmental process|growth|macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|nitrogen compound metabolic process|receptor signaling protein activity|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|lymphangiogenesis|heart development|digestive tract development|post-embryonic development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|retina development in camera-type eye|kidney development|tissue development|growth factor binding|transport|tube development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|lung development|animal organ development|lymph vessel development|cellular nitrogen compound metabolic process|anion binding|secretion by cell|inhibin binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of biomineral tissue development|foregut morphogenesis|organ growth|integral component of plasma membrane|positive regulation of cell differentiation|cation binding|transmembrane signaling receptor activity|cytoplasm|pattern specification process|cell-cell signaling|sensory organ development|receptor complex|organ morphogenesis|protein complex binding|regulation of signal transduction|embryonic morphogenesis|establishment of protein localization|tissue remodeling|negative regulation of biosynthetic process|respiratory tube development|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|cell communication|positive regulation of ossification|signal transduction|regulation of ossification|ossification|receptor signaling protein serine/threonine kinase activity|pancreas development|regulation of catalytic activity|nucleotide binding|lymph vessel morphogenesis|regulation of hormone levels|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|palate development|positive regulation of bone mineralization|regulation of cellular protein metabolic process|skeletal system morphogenesis|response to carbohydrate|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|digestive system development|metal ion binding|cell surface receptor signaling pathway|eye development|purine ribonucleoside triphosphate binding|vasculature development|macromolecule modification|cardiovascular system development|urogenital system development|negative regulation of gene expression|mesoderm development|regulation of RNA metabolic process|respiratory system development|purine nucleoside binding|regulation of osteoblast differentiation|protein transport|biomineral tissue development|embryo development|positive regulation of transferase activity|protein modification process|artery development|gastrulation|amide transport|renal system development|ribonucleoside binding|osteoblast differentiation|regionalization|hormone transport|protein secretion|positive regulation of protein metabolic process|response to growth factor|kinase activity|blood vessel remodeling|positive regulation of osteoblast differentiation|positive regulation of cellular protein metabolic process|epithelium development|phosphate-containing compound metabolic process|odontogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|activin binding|gene expression|venous blood vessel development|secretion|cellular response to organic substance|purine nucleotide binding|regulation of protein metabolic process|retina vasculature development in camera-type eye|macromolecule biosynthetic process|cell differentiation|skeletal system development|digestive tract morphogenesis|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|bone mineralization|embryonic foregut morphogenesis|lymphatic endothelial cell differentiation|regulation of bone mineralization|peptide secretion|endothelium development|insulin secretion|positive regulation of protein modification process|regulation of activin receptor signaling pathway|epithelial cell differentiation|negative regulation of transcription, DNA-templated|camera-type eye development|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|response to monosaccharide|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|peptide transport|negative regulation of RNA biosynthetic process|transmembrane receptor protein serine/threonine kinase activity|BMP signaling pathway|enzyme linked receptor protein signaling pathway|determination of bilateral symmetry|anterior/posterior pattern specification|gastrulation with mouth forming second|protein kinase activity|odontogenesis of dentin-containing tooth|cellular protein modification process|positive regulation of activin receptor signaling pathway|hormone secretion|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of kinase activity|endothelial cell differentiation|transcription from RNA polymerase II promoter|peptide hormone secretion|activin-activated receptor activity|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|determination of left/right symmetry|protein serine/threonine/tyrosine kinase activity|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of phosphorylation|activin receptor signaling pathway|response to glucose|activin receptor activity, type II|activation of protein kinase activity K13596 activin receptor type-2B[2.7.11.30] hsa04060|hsa04550|hsa04350 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human) 3:38453851-38493142 582 744 795 208 275 363 2.4538865830214 2.85091575348056 3.02212849403882 0.785764350881403 0.951330461058226 1.43438980702026 2.77564361018026 1.0571615396533 1.3926264945339 1.44887643588746e-09 3.10515126467941e-08 UP ENSG00000115904 SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:11187] GO:0040011|GO:0032502|GO:0040007|GO:0000003|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0045321|GO:0060076|GO:0043229|GO:0006950|GO:0044702|GO:0071704|GO:0050900|GO:0006955|GO:0019953|GO:0044237|GO:0001776|GO:0048870|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0009893|GO:0032504|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0005085|GO:0048856|GO:0048609|GO:0019222|GO:0048514|GO:0007507|GO:0042127|GO:1903706|GO:0050817|GO:0016337|GO:0006935|GO:0045087|GO:0045595|GO:0070661|GO:0009888|GO:0048468|GO:0043025|GO:0001568|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0070489|GO:0008047|GO:0006952|GO:0030155|GO:0031325|GO:0007420|GO:0010942|GO:0098609|GO:0010243|GO:0001942|GO:0005737|GO:0009611|GO:0060322|GO:0007423|GO:0005088|GO:0006928|GO:0009887|GO:0035264|GO:0042592|GO:1904693|GO:0001775|GO:0009966|GO:0048729|GO:0046983|GO:0048598|GO:0036477|GO:0014069|GO:0030901|GO:0019904|GO:0007028|GO:0010646|GO:0043085|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0061029|GO:0007276|GO:0061383|GO:0016477|GO:0007165|GO:0002260|GO:0009725|GO:0008219|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0050878|GO:0060021|GO:0003205|GO:0071774|GO:0000165|GO:1902533|GO:0051249|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0003677|GO:0060039|GO:0030168|GO:0032943|GO:0005096|GO:0007166|GO:0001654|GO:0002009|GO:0001944|GO:0043412|GO:0030097|GO:0072358|GO:0030098|GO:0007417|GO:0051345|GO:0022405|GO:0046982|GO:0007596|GO:0030695|GO:0017124|GO:0034109|GO:0003007|GO:1901652|GO:0000904|GO:0009790|GO:0071417|GO:0051347|GO:0036211|GO:0042060|GO:0048872|GO:0001782|GO:0022407|GO:1901184|GO:0043434|GO:0007599|GO:0044344|GO:0007159|GO:0051247|GO:0070848|GO:0003209|GO:0002764|GO:0043588|GO:0032270|GO:0042110|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0048854|GO:0007296|GO:0007399|GO:0071310|GO:0097485|GO:0003344|GO:0051246|GO:0046651|GO:0030154|GO:0048858|GO:0005089|GO:0043068|GO:1902531|GO:0072359|GO:0007292|GO:0032870|GO:1901186|GO:0043067|GO:0061384|GO:0097190|GO:0042633|GO:1901532|GO:0048666|GO:0030182|GO:0002521|GO:0007411|GO:0042098|GO:0031401|GO:0050863|GO:0008543|GO:0045742|GO:0043065|GO:1901653|GO:0043408|GO:0043010|GO:0002011|GO:0042058|GO:0030217|GO:0071363|GO:0043087|GO:0016310|GO:0045619|GO:0002768|GO:0038179|GO:0008544|GO:0070486|GO:0061564|GO:0043547|GO:0007167|GO:2000973|GO:0033081|GO:0071375|GO:0043410|GO:0042981|GO:0033077|GO:0002244|GO:0032868|GO:0051057|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0006915|GO:0098773|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0002320|GO:0045580|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0042129|GO:0071593|GO:0042327|GO:0007169|GO:0048010|GO:0002328|GO:0038095|GO:0035023|GO:0071900|GO:0007266|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|growth|reproduction|immune system process|synapse|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|leukocyte activation|excitatory synapse|intracellular organelle|response to stress|single organism reproductive process|organic substance metabolic process|leukocyte migration|immune response|sexual reproduction|cellular metabolic process|leukocyte homeostasis|cell motility|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|blood vessel morphogenesis|heart development|regulation of cell proliferation|regulation of hemopoiesis|coagulation|single organismal cell-cell adhesion|chemotaxis|innate immune response|regulation of cell differentiation|leukocyte proliferation|tissue development|cell development|neuronal cell body|blood vessel development|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|T cell aggregation|enzyme activator activity|defense response|regulation of cell adhesion|positive regulation of cellular metabolic process|brain development|positive regulation of cell death|cell-cell adhesion|response to organonitrogen compound|hair follicle development|cytoplasm|response to wounding|head development|sensory organ development|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|organ morphogenesis|multicellular organism growth|homeostatic process|midbrain morphogenesis|cell activation|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|somatodendritic compartment|postsynaptic density|midbrain development|protein domain specific binding|cytoplasm organization|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|eyelid development in camera-type eye|gamete generation|trabecula morphogenesis|cell migration|signal transduction|lymphocyte homeostasis|response to hormone|cell death|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|palate development|cardiac chamber development|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|DNA binding|pericardium development|platelet activation|mononuclear cell proliferation|GTPase activator activity|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|vasculature development|macromolecule modification|hemopoiesis|cardiovascular system development|lymphocyte differentiation|central nervous system development|positive regulation of hydrolase activity|hair cycle process|protein heterodimerization activity|blood coagulation|GTPase regulator activity|SH3 domain binding|homotypic cell-cell adhesion|heart morphogenesis|response to peptide|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|wound healing|homeostasis of number of cells|B cell homeostasis|regulation of cell-cell adhesion|regulation of ERBB signaling pathway|response to peptide hormone|hemostasis|cellular response to fibroblast growth factor stimulus|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|response to growth factor|cardiac atrium morphogenesis|immune response-regulating signaling pathway|skin development|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|brain morphogenesis|vitellogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|pericardium morphogenesis|regulation of protein metabolic process|lymphocyte proliferation|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|circulatory system development|female gamete generation|cellular response to hormone stimulus|positive regulation of ERBB signaling pathway|regulation of programmed cell death|heart trabecula morphogenesis|apoptotic signaling pathway|hair cycle|regulation of hematopoietic progenitor cell differentiation|neuron development|neuron differentiation|leukocyte differentiation|axon guidance|T cell proliferation|positive regulation of protein modification process|regulation of T cell activation|fibroblast growth factor receptor signaling pathway|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of apoptotic process|cellular response to peptide|regulation of MAPK cascade|camera-type eye development|morphogenesis of an epithelial sheet|regulation of epidermal growth factor receptor signaling pathway|T cell differentiation|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|regulation of lymphocyte differentiation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|epidermis development|leukocyte aggregation|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of pro-B cell differentiation|regulation of T cell differentiation in thymus|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of apoptotic process|T cell differentiation in thymus|hematopoietic progenitor cell differentiation|response to insulin|positive regulation of small GTPase mediated signal transduction|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|apoptotic process|skin epidermis development|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|lymphoid progenitor cell differentiation|regulation of T cell differentiation|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|pro-B cell differentiation|Fc-epsilon receptor signaling pathway|regulation of Rho protein signal transduction|regulation of protein serine/threonine kinase activity|Rho protein signal transduction|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K03099 son of sevenless[-] hsa05200|hsa04151|hsa05206|hsa04010|hsa04014|hsa04810|hsa05205|hsa04510|hsa04062|hsa05034|hsa04630|hsa04072|hsa04910|hsa04650|hsa04068|hsa05160|hsa04722|hsa04660|hsa05231|hsa04915|hsa04912|hsa05215|hsa04540|hsa04012|hsa05220|hsa04662|hsa04917|hsa04664|hsa05211|hsa05214|hsa05221|hsa05223|hsa05213|hsa04320 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Gap junction - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Glioma - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Dorso-ventral axis formation - Homo sapiens (human) 2:38981396-39124345 362 395 505 924 1178 1118 1.58281261492866 1.56963250994501 1.99079502434903 3.61984918680565 4.22604502714236 4.58133091502917 1.71441338307423 4.14240837632573 -1.27275477045961 1.46025081591465e-09 3.12423336557866e-08 DOWN ENSG00000137710 RDX radixin [Source:HGNC Symbol;Acc:HGNC:9944] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0019898|GO:0042995|GO:0097159|GO:0009892|GO:0030055|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0043209|GO:0032420|GO:0071704|GO:0009056|GO:0009986|GO:0044237|GO:0051641|GO:0045177|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009893|GO:0031252|GO:0005615|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0042802|GO:0060341|GO:0051272|GO:0051726|GO:0007049|GO:0016337|GO:0008360|GO:0009888|GO:0048468|GO:1902115|GO:0006810|GO:0022402|GO:0016324|GO:0005938|GO:0060627|GO:0003676|GO:0032421|GO:0032535|GO:0005924|GO:0030155|GO:0005912|GO:0031982|GO:0031325|GO:0051128|GO:2000147|GO:0022607|GO:0098609|GO:0019899|GO:0005737|GO:0032970|GO:0051018|GO:0032880|GO:0001726|GO:0006928|GO:2000643|GO:0009966|GO:0030027|GO:0046983|GO:0045184|GO:0045787|GO:0019904|GO:0032231|GO:0032388|GO:0010646|GO:0007162|GO:0008104|GO:0007154|GO:0044092|GO:0061024|GO:0051270|GO:0060491|GO:0016477|GO:0007165|GO:0070062|GO:0051649|GO:0008092|GO:0009725|GO:1902966|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0030029|GO:2000145|GO:0019538|GO:0043254|GO:0010033|GO:0031323|GO:0010256|GO:0032154|GO:0006996|GO:0051017|GO:0016192|GO:0032268|GO:0000902|GO:0045732|GO:0031333|GO:0031344|GO:1900027|GO:0010468|GO:0008105|GO:0045216|GO:1903392|GO:0090150|GO:0090068|GO:0030864|GO:0003723|GO:0032956|GO:1903047|GO:0007010|GO:0030163|GO:0002064|GO:0032528|GO:0032386|GO:0051117|GO:0034109|GO:0003779|GO:0044770|GO:0097066|GO:0044265|GO:0010628|GO:0030334|GO:0007009|GO:0000278|GO:0046907|GO:2000641|GO:0022408|GO:0022407|GO:0072657|GO:0043242|GO:0007346|GO:0030031|GO:0010564|GO:0008361|GO:0051247|GO:0051346|GO:0022604|GO:0030175|GO:0006461|GO:0043244|GO:0030036|GO:0034613|GO:0070925|GO:0032270|GO:0060429|GO:0035556|GO:0033043|GO:0044267|GO:0042176|GO:0010467|GO:0071310|GO:0005902|GO:0051246|GO:0031529|GO:0030154|GO:0030832|GO:0030335|GO:1903827|GO:1902531|GO:0045931|GO:0032870|GO:0005856|GO:0042803|GO:0005925|GO:0003158|GO:0015629|GO:0043241|GO:0044257|GO:0010737|GO:0001885|GO:0033365|GO:0030033|GO:0034622|GO:0030855|GO:0034332|GO:0072659|GO:0090002|GO:1903364|GO:0044772|GO:0043623|GO:0043087|GO:0045022|GO:0097067|GO:0008064|GO:0016482|GO:1901990|GO:0051494|GO:0045792|GO:0051493|GO:1901989|GO:1901992|GO:0032272|GO:0016197|GO:0045176|GO:1901879|GO:0044822|GO:0097178|GO:1901987|GO:0034111|GO:0051056|GO:0007264|GO:0030863|GO:0007015|GO:1990778|GO:0034260|GO:0030833|GO:1900087|GO:0061028|GO:0051258|GO:2000045|GO:0045446|GO:0007265|GO:0046578|GO:0043624|GO:1902808|GO:1902806|GO:0030837|GO:0030834|GO:0000082|GO:0036010|GO:0061572|GO:0008154|GO:0030835|GO:0032486|GO:0032487|GO:0051693|GO:1902946|GO:0030042|GO:0030041|GO:0051261 locomotion|developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|cell projection|organic cyclic compound binding|negative regulation of metabolic process|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|myelin sheath|stereocilium|organic substance metabolic process|catabolic process|cell surface|cellular metabolic process|cellular localization|apical part of cell|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|cell leading edge|extracellular space|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cellular localization|positive regulation of cellular component movement|regulation of cell cycle|cell cycle|single organismal cell-cell adhesion|regulation of cell shape|tissue development|cell development|regulation of organelle assembly|transport|cell cycle process|apical plasma membrane|cell cortex|regulation of vesicle-mediated transport|nucleic acid binding|stereocilium bundle|regulation of cellular component size|cell-substrate adherens junction|regulation of cell adhesion|adherens junction|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|cell-cell adhesion|enzyme binding|cytoplasm|regulation of actin filament-based process|protein kinase A binding|regulation of protein localization|ruffle|movement of cell or subcellular component|positive regulation of early endosome to late endosome transport|regulation of signal transduction|lamellipodium|protein dimerization activity|establishment of protein localization|positive regulation of cell cycle|protein domain specific binding|regulation of actin filament bundle assembly|positive regulation of intracellular transport|regulation of cell communication|negative regulation of cell adhesion|protein localization|cell communication|negative regulation of molecular function|membrane organization|regulation of cellular component movement|regulation of cell projection assembly|cell migration|signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|response to hormone|positive regulation of protein localization to early endosome|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|regulation of cell motility|protein metabolic process|regulation of protein complex assembly|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|cleavage furrow|organelle organization|actin filament bundle assembly|vesicle-mediated transport|regulation of cellular protein metabolic process|cell morphogenesis|positive regulation of protein catabolic process|negative regulation of protein complex assembly|regulation of cell projection organization|regulation of ruffle assembly|regulation of gene expression|asymmetric protein localization|cell-cell junction organization|negative regulation of adherens junction organization|establishment of protein localization to membrane|positive regulation of cell cycle process|cortical actin cytoskeleton|RNA binding|regulation of actin cytoskeleton organization|mitotic cell cycle process|cytoskeleton organization|protein catabolic process|epithelial cell development|microvillus organization|regulation of intracellular transport|ATPase binding|homotypic cell-cell adhesion|actin binding|cell cycle phase transition|response to thyroid hormone|cellular macromolecule catabolic process|positive regulation of gene expression|regulation of cell migration|plasma membrane organization|mitotic cell cycle|intracellular transport|regulation of early endosome to late endosome transport|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|protein localization to membrane|negative regulation of protein complex disassembly|regulation of mitotic cell cycle|cell projection assembly|regulation of cell cycle process|regulation of cell size|positive regulation of protein metabolic process|negative regulation of hydrolase activity|regulation of cell morphogenesis|filopodium|protein complex assembly|regulation of protein complex disassembly|actin cytoskeleton organization|cellular protein localization|organelle assembly|positive regulation of cellular protein metabolic process|epithelium development|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|gene expression|cellular response to organic substance|microvillus|regulation of protein metabolic process|ruffle organization|cell differentiation|regulation of actin filament length|positive regulation of cell migration|regulation of cellular protein localization|regulation of intracellular signal transduction|positive regulation of mitotic cell cycle|cellular response to hormone stimulus|cytoskeleton|protein homodimerization activity|focal adhesion|endothelium development|actin cytoskeleton|protein complex disassembly|cellular protein catabolic process|protein kinase A signaling|endothelial cell development|protein localization to organelle|microvillus assembly|cellular macromolecular complex assembly|epithelial cell differentiation|adherens junction organization|protein localization to plasma membrane|establishment of protein localization to plasma membrane|positive regulation of cellular protein catabolic process|mitotic cell cycle phase transition|cellular protein complex assembly|regulation of GTPase activity|early endosome to late endosome transport|cellular response to thyroid hormone stimulus|regulation of actin polymerization or depolymerization|cytosolic transport|regulation of mitotic cell cycle phase transition|negative regulation of cytoskeleton organization|negative regulation of cell size|regulation of cytoskeleton organization|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|negative regulation of protein polymerization|endosomal transport|apical protein localization|regulation of protein depolymerization|poly(A) RNA binding|ruffle assembly|regulation of cell cycle phase transition|negative regulation of homotypic cell-cell adhesion|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|cortical cytoskeleton|actin filament organization|protein localization to cell periphery|negative regulation of GTPase activity|regulation of actin filament polymerization|positive regulation of G1/S transition of mitotic cell cycle|establishment of endothelial barrier|protein polymerization|regulation of G1/S transition of mitotic cell cycle|endothelial cell differentiation|Ras protein signal transduction|regulation of Ras protein signal transduction|cellular protein complex disassembly|positive regulation of cell cycle G1/S phase transition|regulation of cell cycle G1/S phase transition|negative regulation of actin filament polymerization|regulation of actin filament depolymerization|G1/S transition of mitotic cell cycle|protein localization to endosome|actin filament bundle organization|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|Rap protein signal transduction|regulation of Rap protein signal transduction|actin filament capping|protein localization to early endosome|actin filament depolymerization|actin filament polymerization|protein depolymerization K05762 radixin[-] hsa05206|hsa04810|hsa05205 MicroRNAs in cancer - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human) 11:110174880-110296722 1407 1695 1801 3678 4763 3887 6.39056942365588 6.99673360391114 7.3751959255387 14.9676954762975 17.7498248191577 16.5458494588176 6.92083298436857 16.4211232514243 -1.24653522020297 1.46091973549535e-09 3.12423336557866e-08 DOWN ENSG00000147174 ACRC acidic repeat containing [Source:HGNC Symbol;Acc:HGNC:15805] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - X:71578411-71613583 217 231 103 36 40 46 3.29396542912344 3.18678051607788 1.40965074780625 0.489623728676825 0.498184772627088 0.654398470198936 2.63013223100252 0.547402323834283 2.26446186907742 1.46053162014032e-09 3.12423336557866e-08 UP ENSG00000100599 RIN3 Ras and Rab interactor 3 [Source:HGNC Symbol;Acc:HGNC:18751] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0005085|GO:0019222|GO:0006810|GO:0008047|GO:0031982|GO:0043231|GO:0019899|GO:0005737|GO:0005088|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005768|GO:0016192|GO:0005096|GO:0031410|GO:0051345|GO:0005769|GO:0030695|GO:0017112|GO:0016023|GO:0031988|GO:0051020|GO:0043087|GO:0043547|GO:0031267|GO:0006897|GO:0017016|GO:0017137 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|regulation of metabolic process|transport|enzyme activator activity|vesicle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|Ras guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|endosome|vesicle-mediated transport|GTPase activator activity|cytoplasmic vesicle|positive regulation of hydrolase activity|early endosome|GTPase regulator activity|Rab guanyl-nucleotide exchange factor activity|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|GTPase binding|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase binding|endocytosis|Ras GTPase binding|Rab GTPase binding - - - - 14:92513774-92688994 44 53 71 178 228 182 0.224431013240342 0.245692056161563 0.326517274966545 0.813484789064343 0.954190942964876 0.870023544166652 0.26554678145615 0.87923309206529 -1.72727964319048 1.47900669367563e-09 3.16064895010682e-08 DOWN ENSG00000115239 ASB3 ankyrin repeat and SOCS box containing 3 [Source:HGNC Symbol;Acc:HGNC:16013] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0007154|GO:0007165|GO:0019538|GO:0043412|GO:0036211|GO:0035556|GO:0044267|GO:0006464|GO:0032446|GO:0016567 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|cell communication|signal transduction|protein metabolic process|macromolecule modification|protein modification process|intracellular signal transduction|cellular protein metabolic process|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination - - - - 2:53532672-53787610 101 111 168 364 402 412 0.816415757397281 0.815440630263351 1.22436815701439 2.63625424869653 2.666136726722 3.12114985903206 0.952074848225007 2.80784694481686 -1.56031739488423 1.52279806122770e-09 3.25190367095076e-08 DOWN ENSG00000177707 PVRL3 poliovirus receptor-related 3 [Source:HGNC Symbol;Acc:HGNC:17664] GO:0032502|GO:0000003|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0030054|GO:0005488|GO:0004872|GO:0044702|GO:0019953|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0042802|GO:0016337|GO:0060041|GO:0009888|GO:0002088|GO:0007275|GO:0048513|GO:0005102|GO:0005912|GO:0045211|GO:0022607|GO:0098609|GO:0005887|GO:0002089|GO:0007423|GO:0009887|GO:0048729|GO:0046983|GO:0050839|GO:0008037|GO:0031226|GO:0005913|GO:0009566|GO:0016021|GO:0043296|GO:0098742|GO:0045216|GO:0001654|GO:0034329|GO:0060042|GO:0042803|GO:0007157|GO:0043010|GO:0034332|GO:0007156|GO:0048592|GO:0048593 developmental process|reproduction|synapse|cell|membrane|cellular process|reproductive process|cell junction|binding|receptor activity|single organism reproductive process|sexual reproduction|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|synaptic membrane|identical protein binding|single organismal cell-cell adhesion|retina development in camera-type eye|tissue development|lens development in camera-type eye|multicellular organism development|animal organ development|receptor binding|adherens junction|postsynaptic membrane|cellular component assembly|cell-cell adhesion|integral component of plasma membrane|lens morphogenesis in camera-type eye|sensory organ development|organ morphogenesis|tissue morphogenesis|protein dimerization activity|cell adhesion molecule binding|cell recognition|intrinsic component of plasma membrane|cell-cell adherens junction|fertilization|integral component of membrane|apical junction complex|cell-cell adhesion via plasma-membrane adhesion molecules|cell-cell junction organization|eye development|cell junction assembly|retina morphogenesis in camera-type eye|protein homodimerization activity|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|camera-type eye development|adherens junction organization|homophilic cell adhesion via plasma membrane adhesion molecules|eye morphogenesis|camera-type eye morphogenesis K06592 poliovirus receptor-related protein 3[-] hsa04514|hsa04520 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Adherens junction - Homo sapiens (human) 3:111070071-111275563 42 75 114 286 327 283 0.373938598580331 0.60686948780215 0.915103547207568 2.28147044221954 2.38873257518989 2.36138363683543 0.631970544530016 2.34386221808162 -1.89095854205753 1.53271001663733e-09 3.27073086752616e-08 DOWN ENSG00000116514 RNF19B ring finger protein 19B [Source:HGNC Symbol;Acc:HGNC:26886] GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0043227|GO:0009893|GO:0031224|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0002250|GO:0031325|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0019787|GO:0000151|GO:0016021|GO:0019538|GO:0031323|GO:0032268|GO:0045732|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0005773|GO:0036211|GO:1990234|GO:0051247|GO:0006508|GO:0032270|GO:0044267|GO:0044390|GO:0042176|GO:0051246|GO:0044257|GO:0061630|GO:0010498|GO:0000323|GO:1903364|GO:0030162|GO:0045862|GO:0051603|GO:0046914|GO:0031624|GO:0006464|GO:1903052|GO:0005764|GO:0019941|GO:1901800|GO:0061136|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0044194|GO:0032434|GO:0032436|GO:0042787|GO:0016567|GO:0000209 macromolecular complex|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intrinsic component of membrane|ligase activity|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|adaptive immune response|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|ubiquitin-like protein transferase activity|ubiquitin ligase complex|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|vacuole|protein modification process|transferase complex|positive regulation of protein metabolic process|proteolysis|positive regulation of cellular protein metabolic process|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein catabolic process|regulation of protein metabolic process|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|lytic vacuole|positive regulation of cellular protein catabolic process|regulation of proteolysis|positive regulation of proteolysis|proteolysis involved in cellular protein catabolic process|transition metal ion binding|ubiquitin conjugating enzyme binding|cellular protein modification process|positive regulation of proteolysis involved in cellular protein catabolic process|lysosome|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|regulation of proteasomal protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|cytolytic granule|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 1:32936445-32964685 646 668 853 312 382 330 11.0110848228625 10.3479466597914 13.108733316528 4.76486381474987 5.34230431678281 5.27157738021991 11.4892549330606 5.12624850391753 1.16430992103748 1.53991049843491e-09 3.28374914430542e-08 UP ENSG00000090487 SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome) [Source:HGNC Symbol;Acc:HGNC:20373] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006955|GO:0043227|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0031090|GO:0002757|GO:0005102|GO:0031982|GO:0043231|GO:0030133|GO:0005737|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0010008|GO:0005794|GO:0005768|GO:0005829|GO:0005798|GO:0007166|GO:0031410|GO:0016023|GO:0002429|GO:0042609|GO:0031988|GO:0002764|GO:0030140|GO:0002768|GO:0030135|GO:0050851|GO:0030136 immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|immune response|membrane-bounded organelle|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|endomembrane system|organelle membrane|immune response-activating signal transduction|receptor binding|vesicle|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|endosome membrane|Golgi apparatus|endosome|cytosol|Golgi-associated vesicle|cell surface receptor signaling pathway|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|immune response-activating cell surface receptor signaling pathway|CD4 receptor binding|membrane-bounded vesicle|immune response-regulating signaling pathway|trans-Golgi network transport vesicle|immune response-regulating cell surface receptor signaling pathway|coated vesicle|antigen receptor-mediated signaling pathway|clathrin-coated vesicle K19367 maspardin[-] hsa04144 Endocytosis - Homo sapiens (human) 15:64963021-64990310 549 603 681 1555 1630 1404 4.78493694364678 4.77640137732094 5.35137408352948 12.1431645780813 11.6562594448243 11.4683208835489 4.9709041348324 11.7559149688182 -1.24180664313107 1.544609069615e-09 3.29141749923528e-08 DOWN ENSG00000198088 NUP62CL nucleoporin 62kDa C-terminal like [Source:HGNC Symbol;Acc:HGNC:25960] GO:0005198|GO:0005623|GO:0005488|GO:0043229|GO:0017056|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0043231|GO:0005635|GO:0045184|GO:0008104|GO:0015031|GO:0005634|GO:0005643 structural molecule activity|cell|binding|intracellular organelle|structural constituent of nuclear pore|membrane-bounded organelle|intracellular|protein binding|endomembrane system|transport|intracellular membrane-bounded organelle|nuclear envelope|establishment of protein localization|protein localization|protein transport|nucleus|nuclear pore - - - - X:107123427-107206433 33 51 76 186 202 252 0.761104326283924 1.06901950788732 1.58037119499275 3.8436432590802 3.82253518574568 5.44705684307043 1.136831676388 4.37107842929877 -1.9429706051754 1.54937853634108e-09 3.29922587902473e-08 DOWN ENSG00000082701 GSK3B glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0040013|GO:0042995|GO:0032259|GO:0097159|GO:0009892|GO:0014823|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0060076|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0044089|GO:0007623|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0030427|GO:0045927|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:1903828|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0060341|GO:0008284|GO:0044262|GO:0042127|GO:0007049|GO:0006949|GO:1900181|GO:0043198|GO:0050804|GO:0042391|GO:0006935|GO:0045087|GO:0045595|GO:0006725|GO:0009888|GO:0014741|GO:0008013|GO:0048468|GO:0043025|GO:0006810|GO:0022402|GO:0021766|GO:0051130|GO:0009612|GO:1901360|GO:0010941|GO:0007275|GO:0045596|GO:0048513|GO:0032535|GO:0005102|GO:0016358|GO:0002039|GO:0034641|GO:0043168|GO:0030307|GO:0015980|GO:0044281|GO:0006952|GO:0030155|GO:0030900|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0030426|GO:0033554|GO:0007420|GO:0050806|GO:0022607|GO:0010942|GO:0051098|GO:2000077|GO:0050803|GO:0061061|GO:0045597|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0003012|GO:0030529|GO:0007267|GO:0071109|GO:0032886|GO:0060322|GO:0051018|GO:0021987|GO:0032880|GO:0009408|GO:0005975|GO:0051222|GO:0006928|GO:0009887|GO:0032403|GO:0030877|GO:0031018|GO:0043005|GO:0031589|GO:0009966|GO:0045184|GO:0050839|GO:0009890|GO:0043197|GO:0048639|GO:0036477|GO:0097481|GO:0014069|GO:0006979|GO:0060548|GO:0042493|GO:0032387|GO:0032388|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0008104|GO:0007163|GO:0007154|GO:0044092|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0009968|GO:0048638|GO:0090559|GO:1990909|GO:0051649|GO:0045785|GO:0008134|GO:0008092|GO:0009725|GO:0008219|GO:0051271|GO:0090316|GO:0031016|GO:0090317|GO:0021543|GO:0050790|GO:0000166|GO:0030030|GO:0006091|GO:0043086|GO:0048869|GO:2000145|GO:0010035|GO:0021537|GO:0009967|GO:0044249|GO:0009266|GO:0007017|GO:0019538|GO:0031334|GO:0043254|GO:0023014|GO:0010033|GO:0098857|GO:0051224|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0006996|GO:0055114|GO:0007568|GO:0071774|GO:0060560|GO:1900034|GO:0050768|GO:0000165|GO:2001235|GO:0032268|GO:0030111|GO:0000902|GO:0006109|GO:0005829|GO:0045732|GO:0031175|GO:0005813|GO:0031333|GO:0005976|GO:0051354|GO:2000171|GO:0031344|GO:2000463|GO:0010468|GO:0034645|GO:0048660|GO:0030178|GO:0042308|GO:0048167|GO:0007166|GO:2000736|GO:0051100|GO:0033993|GO:0035639|GO:0030424|GO:0043412|GO:0072594|GO:0044309|GO:0050773|GO:0034097|GO:1990478|GO:0030163|GO:0007417|GO:0001085|GO:0051345|GO:0042542|GO:0034236|GO:0010720|GO:0007005|GO:0006984|GO:0042692|GO:0043069|GO:0002064|GO:0048813|GO:0051252|GO:0005815|GO:0032386|GO:0060078|GO:0001883|GO:1901216|GO:0070997|GO:0010721|GO:0051223|GO:0015031|GO:0044265|GO:1901652|GO:0048659|GO:0021761|GO:0031346|GO:0000904|GO:0090257|GO:0071417|GO:0010628|GO:0010038|GO:0030334|GO:0043200|GO:0071869|GO:0048661|GO:0000320|GO:0036211|GO:0032269|GO:0046902|GO:0006306|GO:0030856|GO:0070201|GO:0007160|GO:0046907|GO:0001764|GO:0005178|GO:0032549|GO:0048156|GO:0031345|GO:0003309|GO:0033692|GO:0060485|GO:0035270|GO:0046827|GO:0050769|GO:0030010|GO:0043434|GO:0071867|GO:0034599|GO:0030425|GO:0044344|GO:0045838|GO:0008361|GO:0005977|GO:0034605|GO:0005996|GO:0051099|GO:0010810|GO:0051247|GO:0048471|GO:0070848|GO:0006508|GO:0071514|GO:0022604|GO:0006259|GO:0005739|GO:0002764|GO:0051059|GO:0006461|GO:0016301|GO:1901214|GO:0051881|GO:0030336|GO:0034613|GO:0051341|GO:0019900|GO:0006112|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0043467|GO:0000302|GO:0051054|GO:0006796|GO:1901030|GO:0035556|GO:0060359|GO:0071241|GO:0033043|GO:0044267|GO:0051174|GO:0010611|GO:0042176|GO:0014896|GO:0048864|GO:0010467|GO:0017038|GO:0030516|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:1902532|GO:0017076|GO:0098815|GO:0031328|GO:0051246|GO:0030177|GO:0071260|GO:0010039|GO:0010770|GO:0006983|GO:0009059|GO:0010811|GO:0030154|GO:0048858|GO:0045121|GO:0043068|GO:0048469|GO:1903827|GO:1902531|GO:0016070|GO:0016773|GO:0034976|GO:0005856|GO:0010614|GO:0010557|GO:0030857|GO:0005634|GO:0016051|GO:0043067|GO:1990138|GO:0048545|GO:0097305|GO:0035254|GO:1990418|GO:0006606|GO:0051960|GO:0097190|GO:2000738|GO:0045773|GO:0007006|GO:0044389|GO:0043393|GO:0010638|GO:0048666|GO:0030182|GO:0005978|GO:0003323|GO:0031625|GO:0035728|GO:0070059|GO:0007411|GO:0016055|GO:0010918|GO:1904589|GO:0019318|GO:0044030|GO:0044257|GO:0007520|GO:1901028|GO:0045893|GO:0048863|GO:0097193|GO:2001222|GO:0010975|GO:0042551|GO:0045444|GO:0033365|GO:0033157|GO:0031401|GO:0008543|GO:0090090|GO:0048168|GO:0043065|GO:0071242|GO:1902065|GO:0010498|GO:2000466|GO:0051169|GO:0030855|GO:0043408|GO:0010769|GO:0060828|GO:0000271|GO:0043523|GO:2000465|GO:0032774|GO:0002066|GO:1903364|GO:0035255|GO:0005524|GO:0006839|GO:0010226|GO:0030162|GO:2001141|GO:0097192|GO:0014031|GO:0008637|GO:0045862|GO:0043525|GO:0071363|GO:0043087|GO:0030554|GO:0016310|GO:0043627|GO:0006605|GO:0002768|GO:0038179|GO:0006611|GO:1990776|GO:0010822|GO:0071407|GO:0006304|GO:0061564|GO:0016482|GO:0071281|GO:0006886|GO:0048017|GO:0010906|GO:0040029|GO:2000278|GO:0043547|GO:0071871|GO:0097345|GO:1903429|GO:0051603|GO:0007167|GO:1902108|GO:0001952|GO:0015630|GO:0035794|GO:0010821|GO:0032092|GO:0048814|GO:0001954|GO:0051146|GO:0032355|GO:0042981|GO:0071345|GO:2001223|GO:0042992|GO:0043066|GO:0004672|GO:0043409|GO:0045719|GO:2000074|GO:0010040|GO:0033673|GO:0032868|GO:0048762|GO:0051402|GO:0060079|GO:0050774|GO:0042306|GO:2000573|GO:0045665|GO:1900180|GO:0034614|GO:0019901|GO:0050772|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0090263|GO:0048812|GO:0032091|GO:0001837|GO:0006349|GO:0097191|GO:0070873|GO:0042991|GO:0071897|GO:0010976|GO:0010977|GO:0043549|GO:0071870|GO:0006351|GO:0070301|GO:0006915|GO:0006355|GO:0048675|GO:0071248|GO:0032769|GO:0046824|GO:0045666|GO:0005979|GO:0048011|GO:0003300|GO:0014043|GO:1903533|GO:0045944|GO:0014041|GO:0006366|GO:0006913|GO:0045859|GO:0071285|GO:1903052|GO:0048015|GO:0036016|GO:0044337|GO:0006469|GO:1904339|GO:0006357|GO:0007409|GO:0019941|GO:0051001|GO:0006468|GO:0043407|GO:0048699|GO:1903506|GO:0006006|GO:1901800|GO:0046825|GO:0060070|GO:0002068|GO:0043405|GO:0051534|GO:0035729|GO:0042325|GO:0044380|GO:0001932|GO:0018193|GO:1903351|GO:0042326|GO:0051531|GO:0038093|GO:0050999|GO:0014902|GO:0004674|GO:1902110|GO:0001934|GO:0010657|GO:0042990|GO:0001933|GO:0010656|GO:0050321|GO:0050770|GO:0061136|GO:0045664|GO:0044026|GO:0042327|GO:0071282|GO:0071542|GO:0034504|GO:0046822|GO:0043161|GO:0007268|GO:0007169|GO:0036018|GO:0006511|GO:0002067|GO:0051170|GO:0051168|GO:0044027|GO:0046777|GO:0033138|GO:0038095|GO:0071901|GO:0032434|GO:0032436|GO:0018105|GO:0033135|GO:0071900|GO:0018107|GO:0034392|GO:1904338|GO:0038127|GO:0034391|GO:0010800|GO:0035883|GO:0007173|GO:0035372 locomotion|developmental process|growth|macromolecular complex|immune system process|synapse|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|negative regulation of locomotion|cell projection|methylation|organic cyclic compound binding|negative regulation of metabolic process|response to activity|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|excitatory synapse|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|positive regulation of cellular component biogenesis|circadian rhythm|organic substance metabolic process|catabolic process|ion binding|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|site of polarized growth|positive regulation of growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|negative regulation of cellular protein localization|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|cellular carbohydrate metabolic process|regulation of cell proliferation|cell cycle|syncytium formation|negative regulation of protein localization to nucleus|dendritic shaft|modulation of synaptic transmission|regulation of membrane potential|chemotaxis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|negative regulation of muscle hypertrophy|beta-catenin binding|cell development|neuronal cell body|transport|cell cycle process|hippocampus development|positive regulation of cellular component organization|response to mechanical stimulus|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|animal organ development|regulation of cellular component size|receptor binding|dendrite development|p53 binding|cellular nitrogen compound metabolic process|anion binding|positive regulation of cell growth|energy derivation by oxidation of organic compounds|small molecule metabolic process|defense response|regulation of cell adhesion|forebrain development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|growth cone|cellular response to stress|brain development|positive regulation of synaptic transmission|cellular component assembly|positive regulation of cell death|regulation of binding|negative regulation of type B pancreatic cell development|regulation of synapse structure or activity|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|muscle system process|intracellular ribonucleoprotein complex|cell-cell signaling|superior temporal gyrus development|regulation of microtubule-based process|head development|protein kinase A binding|cerebral cortex development|regulation of protein localization|response to heat|carbohydrate metabolic process|positive regulation of protein transport|movement of cell or subcellular component|organ morphogenesis|protein complex binding|beta-catenin destruction complex|endocrine pancreas development|neuron projection|cell-substrate adhesion|regulation of signal transduction|establishment of protein localization|cell adhesion molecule binding|negative regulation of biosynthetic process|dendritic spine|positive regulation of developmental growth|somatodendritic compartment|neuronal postsynaptic density|postsynaptic density|response to oxidative stress|negative regulation of cell death|response to drug|negative regulation of intracellular transport|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|protein localization|establishment or maintenance of cell polarity|cell communication|negative regulation of molecular function|membrane organization|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|negative regulation of signal transduction|regulation of developmental growth|regulation of membrane permeability|Wnt signalosome|establishment of localization in cell|positive regulation of cell adhesion|transcription factor binding|cytoskeletal protein binding|response to hormone|cell death|negative regulation of cellular component movement|positive regulation of intracellular protein transport|pancreas development|negative regulation of intracellular protein transport|pallium development|regulation of catalytic activity|nucleotide binding|cell projection organization|generation of precursor metabolites and energy|negative regulation of catalytic activity|cellular developmental process|regulation of cell motility|response to inorganic substance|telencephalon development|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|microtubule-based process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|negative regulation of protein transport|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|organelle organization|oxidation-reduction process|aging|response to fibroblast growth factor|developmental growth involved in morphogenesis|regulation of cellular response to heat|negative regulation of neurogenesis|MAPK cascade|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|regulation of carbohydrate metabolic process|cytosol|positive regulation of protein catabolic process|neuron projection development|centrosome|negative regulation of protein complex assembly|polysaccharide metabolic process|negative regulation of oxidoreductase activity|negative regulation of dendrite development|regulation of cell projection organization|positive regulation of excitatory postsynaptic potential|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|negative regulation of Wnt signaling pathway|negative regulation of protein import into nucleus|regulation of synaptic plasticity|cell surface receptor signaling pathway|regulation of stem cell differentiation|negative regulation of binding|response to lipid|purine ribonucleoside triphosphate binding|axon|macromolecule modification|establishment of protein localization to organelle|neuron spine|regulation of dendrite development|response to cytokine|response to ultrasound|protein catabolic process|central nervous system development|RNA polymerase II transcription factor binding|positive regulation of hydrolase activity|response to hydrogen peroxide|protein kinase A catalytic subunit binding|positive regulation of cell development|mitochondrion organization|ER-nucleus signaling pathway|muscle cell differentiation|negative regulation of programmed cell death|epithelial cell development|dendrite morphogenesis|regulation of RNA metabolic process|microtubule organizing center|regulation of intracellular transport|regulation of postsynaptic membrane potential|purine nucleoside binding|positive regulation of neuron death|neuron death|negative regulation of cell development|regulation of protein transport|protein transport|cellular macromolecule catabolic process|response to peptide|smooth muscle cell proliferation|limbic system development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|regulation of muscle system process|cellular response to organonitrogen compound|positive regulation of gene expression|response to metal ion|regulation of cell migration|response to amino acid|response to catecholamine|positive regulation of smooth muscle cell proliferation|re-entry into mitotic cell cycle|protein modification process|negative regulation of cellular protein metabolic process|regulation of mitochondrial membrane permeability|DNA methylation|regulation of epithelial cell differentiation|regulation of establishment of protein localization|cell-matrix adhesion|intracellular transport|neuron migration|integrin binding|ribonucleoside binding|tau protein binding|negative regulation of cell projection organization|type B pancreatic cell differentiation|cellular polysaccharide biosynthetic process|mesenchyme development|endocrine system development|positive regulation of protein export from nucleus|positive regulation of neurogenesis|establishment of cell polarity|response to peptide hormone|response to monoamine|cellular response to oxidative stress|dendrite|cellular response to fibroblast growth factor stimulus|positive regulation of membrane potential|regulation of cell size|glycogen metabolic process|cellular response to heat|monosaccharide metabolic process|positive regulation of binding|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|perinuclear region of cytoplasm|response to growth factor|proteolysis|genetic imprinting|regulation of cell morphogenesis|DNA metabolic process|mitochondrion|immune response-regulating signaling pathway|NF-kappaB binding|protein complex assembly|kinase activity|regulation of neuron death|regulation of mitochondrial membrane potential|negative regulation of cell migration|cellular protein localization|regulation of oxidoreductase activity|kinase binding|energy reserve metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|regulation of generation of precursor metabolites and energy|response to reactive oxygen species|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|intracellular signal transduction|response to ammonium ion|cellular response to inorganic substance|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of cardiac muscle hypertrophy|regulation of protein catabolic process|muscle hypertrophy|stem cell development|gene expression|protein import|regulation of axon extension|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|negative regulation of intracellular signal transduction|purine nucleotide binding|modulation of excitatory postsynaptic potential|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|cellular response to mechanical stimulus|response to iron ion|positive regulation of cell morphogenesis involved in differentiation|ER overload response|macromolecule biosynthetic process|positive regulation of cell-substrate adhesion|cell differentiation|cell projection morphogenesis|membrane raft|positive regulation of programmed cell death|cell maturation|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|response to endoplasmic reticulum stress|cytoskeleton|negative regulation of cardiac muscle hypertrophy|positive regulation of macromolecule biosynthetic process|negative regulation of epithelial cell differentiation|nucleus|carbohydrate biosynthetic process|regulation of programmed cell death|neuron projection extension|response to steroid hormone|response to alcohol|glutamate receptor binding|response to insulin-like growth factor stimulus|protein import into nucleus|regulation of nervous system development|apoptotic signaling pathway|positive regulation of stem cell differentiation|positive regulation of axon extension|mitochondrial membrane organization|ubiquitin-like protein ligase binding|regulation of protein binding|positive regulation of organelle organization|neuron development|neuron differentiation|glycogen biosynthetic process|type B pancreatic cell development|ubiquitin protein ligase binding|response to hepatocyte growth factor|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|axon guidance|Wnt signaling pathway|positive regulation of mitochondrial membrane potential|regulation of protein import|hexose metabolic process|regulation of DNA methylation|cellular protein catabolic process|myoblast fusion|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|positive regulation of transcription, DNA-templated|stem cell differentiation|intrinsic apoptotic signaling pathway|regulation of neuron migration|regulation of neuron projection development|neuron maturation|fat cell differentiation|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of neuronal synaptic plasticity|positive regulation of apoptotic process|cellular response to ammonium ion|response to L-glutamate|proteasomal protein catabolic process|negative regulation of glycogen (starch) synthase activity|nuclear transport|epithelial cell differentiation|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|regulation of canonical Wnt signaling pathway|polysaccharide biosynthetic process|regulation of neuron apoptotic process|regulation of glycogen (starch) synthase activity|RNA biosynthetic process|columnar/cuboidal epithelial cell development|positive regulation of cellular protein catabolic process|ionotropic glutamate receptor binding|ATP binding|mitochondrial transport|response to lithium ion|regulation of proteolysis|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|mesenchymal cell development|apoptotic mitochondrial changes|positive regulation of proteolysis|positive regulation of neuron apoptotic process|cellular response to growth factor stimulus|regulation of GTPase activity|adenyl nucleotide binding|phosphorylation|response to estrogen|protein targeting|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|protein export from nucleus|response to angiotensin|positive regulation of mitochondrion organization|cellular response to organic cyclic compound|DNA modification|axon development|cytosolic transport|cellular response to iron ion|intracellular protein transport|inositol lipid-mediated signaling|regulation of glucose metabolic process|regulation of gene expression, epigenetic|regulation of DNA biosynthetic process|positive regulation of GTPase activity|response to epinephrine|mitochondrial outer membrane permeabilization|regulation of cell maturation|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|regulation of mitochondrial membrane permeability involved in apoptotic process|regulation of cell-matrix adhesion|microtubule cytoskeleton|positive regulation of mitochondrial membrane permeability|regulation of mitochondrion organization|positive regulation of protein binding|regulation of dendrite morphogenesis|positive regulation of cell-matrix adhesion|striated muscle cell differentiation|response to estradiol|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of neuron migration|negative regulation of transcription factor import into nucleus|negative regulation of apoptotic process|protein kinase activity|negative regulation of MAPK cascade|negative regulation of glycogen biosynthetic process|regulation of type B pancreatic cell development|response to iron(II) ion|negative regulation of kinase activity|response to insulin|mesenchymal cell differentiation|neuron apoptotic process|excitatory postsynaptic potential|negative regulation of dendrite morphogenesis|regulation of protein import into nucleus|positive regulation of DNA biosynthetic process|negative regulation of neuron differentiation|regulation of protein localization to nucleus|cellular response to reactive oxygen species|protein kinase binding|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|positive regulation of canonical Wnt signaling pathway|neuron projection morphogenesis|negative regulation of protein binding|epithelial to mesenchymal transition|regulation of gene expression by genetic imprinting|extrinsic apoptotic signaling pathway|regulation of glycogen metabolic process|transcription factor import into nucleus|DNA biosynthetic process|positive regulation of neuron projection development|negative regulation of neuron projection development|regulation of kinase activity|cellular response to catecholamine stimulus|transcription, DNA-templated|cellular response to hydrogen peroxide|apoptotic process|regulation of transcription, DNA-templated|axon extension|cellular response to metal ion|negative regulation of monooxygenase activity|positive regulation of nucleocytoplasmic transport|positive regulation of neuron differentiation|regulation of glycogen biosynthetic process|neurotrophin TRK receptor signaling pathway|cardiac muscle hypertrophy|negative regulation of neuron maturation|regulation of protein targeting|positive regulation of transcription from RNA polymerase II promoter|regulation of neuron maturation|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|regulation of protein kinase activity|cellular response to lithium ion|positive regulation of proteolysis involved in cellular protein catabolic process|phosphatidylinositol-mediated signaling|cellular response to interleukin-3|canonical Wnt signaling pathway involved in positive regulation of apoptotic process|negative regulation of protein kinase activity|negative regulation of dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter|axonogenesis|modification-dependent protein catabolic process|negative regulation of nitric-oxide synthase activity|protein phosphorylation|negative regulation of MAP kinase activity|generation of neurons|regulation of nucleic acid-templated transcription|glucose metabolic process|positive regulation of proteasomal protein catabolic process|regulation of protein export from nucleus|canonical Wnt signaling pathway|glandular epithelial cell development|regulation of MAP kinase activity|negative regulation of NFAT protein import into nucleus|cellular response to hepatocyte growth factor stimulus|regulation of phosphorylation|protein localization to cytoskeleton|regulation of protein phosphorylation|peptidyl-amino acid modification|cellular response to dopamine|negative regulation of phosphorylation|NFAT protein import into nucleus|Fc receptor signaling pathway|regulation of nitric-oxide synthase activity|myotube differentiation|protein serine/threonine kinase activity|positive regulation of mitochondrial membrane permeability involved in apoptotic process|positive regulation of protein phosphorylation|muscle cell apoptotic process|regulation of transcription factor import into nucleus|negative regulation of protein phosphorylation|negative regulation of muscle cell apoptotic process|tau-protein kinase activity|regulation of axonogenesis|regulation of proteasomal protein catabolic process|regulation of neuron differentiation|DNA hypermethylation|positive regulation of phosphorylation|cellular response to iron(II) ion|dopaminergic neuron differentiation|protein localization to nucleus|regulation of nucleocytoplasmic transport|proteasome-mediated ubiquitin-dependent protein catabolic process|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|cellular response to erythropoietin|ubiquitin-dependent protein catabolic process|glandular epithelial cell differentiation|nuclear import|nuclear export|hypermethylation of CpG island|protein autophosphorylation|positive regulation of peptidyl-serine phosphorylation|Fc-epsilon receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|negative regulation of smooth muscle cell apoptotic process|regulation of dopaminergic neuron differentiation|ERBB signaling pathway|regulation of smooth muscle cell apoptotic process|positive regulation of peptidyl-threonine phosphorylation|enteroendocrine cell differentiation|epidermal growth factor receptor signaling pathway|protein localization to microtubule K03083 glycogen synthase kinase 3 beta[2.7.11.26] hsa05200|hsa04151|hsa05166|hsa04510|hsa05169|hsa04062|hsa05164|hsa04360|hsa05010|hsa04390|hsa04932|hsa04310|hsa04550|hsa04910|hsa05162|hsa05160|hsa04728|hsa04110|hsa04722|hsa04919|hsa04931|hsa04660|hsa04916|hsa05215|hsa04012|hsa04662|hsa04917|hsa05210|hsa05213 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Measles - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human) 3:119821323-120094417 752 1050 1415 2816 2753 3201 5.96814663885665 7.5734015519285 10.1249381811727 20.0240607908577 17.9265203072522 23.8087429917791 7.88882879065262 20.5864413632963 -1.38381143018352 1.55072099963625e-09 3.29973091398009e-08 DOWN ENSG00000153904 DDAH1 dimethylarginine dimethylaminohydrolase 1 [Source:HGNC Symbol;Acc:HGNC:2715] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0006575|GO:1903409|GO:0001568|GO:0006082|GO:0007275|GO:0034641|GO:0043168|GO:0044281|GO:2001057|GO:0031982|GO:0031325|GO:0043231|GO:0043169|GO:0005737|GO:0006520|GO:0016810|GO:0072593|GO:0043177|GO:0001525|GO:0007154|GO:0007165|GO:0070062|GO:0008217|GO:0050790|GO:0044249|GO:0031323|GO:0003013|GO:0005829|GO:0046872|GO:0001944|GO:0072358|GO:2000377|GO:0046209|GO:1903428|GO:0000052|GO:0045766|GO:0016813|GO:0045765|GO:0009063|GO:0045428|GO:0005739|GO:0051341|GO:1901342|GO:0035556|GO:0031406|GO:0031328|GO:0006809|GO:0072359|GO:0008015|GO:1903426|GO:0003073|GO:2000379|GO:0046395|GO:0045429|GO:0016597|GO:0019752|GO:0019932|GO:0016403|GO:0006525|GO:0050999|GO:0007263|GO:0006527 developmental process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|cellular modified amino acid metabolic process|reactive oxygen species biosynthetic process|blood vessel development|organic acid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|reactive nitrogen species metabolic process|vesicle|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular amino acid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|reactive oxygen species metabolic process|organic acid binding|angiogenesis|cell communication|signal transduction|extracellular exosome|regulation of blood pressure|regulation of catalytic activity|cellular biosynthetic process|regulation of cellular metabolic process|circulatory system process|cytosol|metal ion binding|vasculature development|cardiovascular system development|regulation of reactive oxygen species metabolic process|nitric oxide metabolic process|positive regulation of reactive oxygen species biosynthetic process|citrulline metabolic process|positive regulation of angiogenesis|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines|regulation of angiogenesis|cellular amino acid catabolic process|regulation of nitric oxide biosynthetic process|mitochondrion|regulation of oxidoreductase activity|regulation of vasculature development|intracellular signal transduction|carboxylic acid binding|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|circulatory system development|blood circulation|regulation of reactive oxygen species biosynthetic process|regulation of systemic arterial blood pressure|positive regulation of reactive oxygen species metabolic process|carboxylic acid catabolic process|positive regulation of nitric oxide biosynthetic process|amino acid binding|carboxylic acid metabolic process|second-messenger-mediated signaling|dimethylargininase activity|arginine metabolic process|regulation of nitric-oxide synthase activity|nitric oxide mediated signal transduction|arginine catabolic process - - - - 1:85318481-85578363 373 477 816 1637 1848 1461 2.16269219731313 2.51353061609623 4.265701267397 8.50417715367475 8.79135425088389 7.93898384245207 2.98064136026879 8.4115050823369 -1.49674117064796 1.55387152100089e-09 3.3040797997123e-08 DOWN ENSG00000106993 CDC37L1 cell division cycle 37-like 1 [Source:HGNC Symbol;Acc:HGNC:17179] GO:0005623|GO:0009987|GO:0005488|GO:0006457|GO:0005622|GO:0005515|GO:0051087|GO:0005737|GO:0031647|GO:0051082|GO:0031072|GO:0050821 cell|cellular process|binding|protein folding|intracellular|protein binding|chaperone binding|cytoplasm|regulation of protein stability|unfolded protein binding|heat shock protein binding|protein stabilization - - - - 9:4679559-4708398 218 214 249 79 84 95 3.2464517038185 2.89631213577281 3.34322128060681 1.0540899074547 1.02636184179453 1.32587820950266 3.16199504006604 1.13544331958396 1.47757941500582 1.57714324525159e-09 3.35117682873601e-08 UP ENSG00000060491 OGFR opioid growth factor receptor [Source:HGNC Symbol;Acc:HGNC:15768] GO:0040007|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0016049|GO:0038023|GO:0016043|GO:0043227|GO:0040008|GO:0005622|GO:0005515|GO:0051128|GO:0043231|GO:0004888|GO:0005737|GO:0007154|GO:0007165|GO:0001558|GO:0007186|GO:0008528|GO:0004930|GO:0005634|GO:0038003|GO:0004985 growth|signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|cell growth|signaling receptor activity|cellular component organization|membrane-bounded organelle|regulation of growth|intracellular|protein binding|regulation of cellular component organization|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|cell communication|signal transduction|regulation of cell growth|G-protein coupled receptor signaling pathway|G-protein coupled peptide receptor activity|G-protein coupled receptor activity|nucleus|opioid receptor signaling pathway|opioid receptor activity - - - - 20:62804835-62814000 2203 2180 2143 1047 1160 963 25.9895421528872 23.3733324016542 22.7939950620467 11.0669680788927 11.228199353466 10.6473001514824 24.052289872196 10.980822527947 1.13118812604962 1.59384334248477e-09 3.38425313986773e-08 UP ENSG00000115762 PLEKHB2 pleckstrin homology domain containing B2 [Source:HGNC Symbol;Acc:HGNC:19236] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0005737|GO:0010008|GO:0005768|GO:0055037|GO:0055038 cell|membrane|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|endosome membrane|endosome|recycling endosome|recycling endosome membrane - - - - 2:131104847-131353709 4383 4526 4388 2242 2217 2061 21.5709746161687 20.2438387466613 19.4705918451973 9.88624940364712 8.95224459367767 9.50616132984239 20.4284684026758 9.44821844238906 1.11246681870012 1.61169607546724e-09 3.41972811918969e-08 UP ENSG00000188976 NOC2L NOC2-like nucleolar associated transcriptional repressor [Source:HGNC Symbol;Acc:HGNC:24517] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009628|GO:0044237|GO:0051641|GO:0023051|GO:0000989|GO:0016043|GO:0043227|GO:0023057|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:0042393|GO:0009314|GO:0006810|GO:1901360|GO:0010941|GO:0016570|GO:0003676|GO:0034641|GO:0046483|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0032403|GO:0009966|GO:0009890|GO:0003682|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0051649|GO:0008134|GO:0008219|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0032268|GO:0010468|GO:0034645|GO:0003714|GO:0003723|GO:0043412|GO:0010629|GO:0043069|GO:0031056|GO:2001234|GO:0051252|GO:0006325|GO:0070491|GO:0016573|GO:0036211|GO:0032269|GO:0046907|GO:0031981|GO:0071478|GO:0005654|GO:0031491|GO:0012501|GO:0035556|GO:0033043|GO:0044267|GO:0010467|GO:1902532|GO:0051246|GO:0009059|GO:1902531|GO:0016070|GO:0005634|GO:0009416|GO:0043067|GO:0097190|GO:0097193|GO:2001242|GO:2001251|GO:0009411|GO:0051169|GO:0045892|GO:0032774|GO:0035067|GO:2001141|GO:2001243|GO:0033044|GO:1902679|GO:0006333|GO:0071482|GO:0031497|GO:0042981|GO:0035065|GO:0043066|GO:0016568|GO:0044822|GO:0006464|GO:0071103|GO:0032066|GO:0006351|GO:0006915|GO:0006355|GO:2000107|GO:0006323|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:1901984|GO:0018193|GO:0000122|GO:0034644|GO:2000757|GO:0006473|GO:0018205|GO:0070228|GO:0018394|GO:0002902|GO:0002903|GO:0001783|GO:0006475|GO:0018393 signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of signaling|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|histone binding|response to radiation|transport|organic cyclic compound metabolic process|regulation of cell death|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|protein complex binding|regulation of signal transduction|negative regulation of biosynthetic process|chromatin binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|establishment of localization in cell|transcription factor binding|cell death|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|RNA binding|macromolecule modification|negative regulation of gene expression|negative regulation of programmed cell death|regulation of histone modification|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|chromatin organization|repressing transcription factor binding|histone acetylation|protein modification process|negative regulation of cellular protein metabolic process|intracellular transport|nuclear lumen|cellular response to radiation|nucleoplasm|nucleosome binding|programmed cell death|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|gene expression|negative regulation of intracellular signal transduction|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|nucleus|response to light stimulus|regulation of programmed cell death|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|negative regulation of chromosome organization|response to UV|nuclear transport|negative regulation of transcription, DNA-templated|RNA biosynthetic process|negative regulation of histone acetylation|regulation of RNA biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway|regulation of chromosome organization|negative regulation of RNA biosynthetic process|chromatin assembly or disassembly|cellular response to light stimulus|chromatin assembly|regulation of apoptotic process|regulation of histone acetylation|negative regulation of apoptotic process|chromatin modification|poly(A) RNA binding|cellular protein modification process|DNA conformation change|nucleolus to nucleoplasm transport|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|negative regulation of leukocyte apoptotic process|DNA packaging|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of protein acetylation|peptidyl-amino acid modification|negative regulation of transcription from RNA polymerase II promoter|cellular response to UV|negative regulation of peptidyl-lysine acetylation|protein acetylation|peptidyl-lysine modification|regulation of lymphocyte apoptotic process|peptidyl-lysine acetylation|regulation of B cell apoptotic process|negative regulation of B cell apoptotic process|B cell apoptotic process|internal protein amino acid acetylation|internal peptidyl-lysine acetylation - - - - 1:944204-959309 534 626 640 1764 2212 1236 5.21013953930212 5.55088440700872 5.62991521437749 15.4206953136477 17.7076429861662 11.3019967906784 5.46364638689611 14.8101116968308 -1.43864650239472 1.61284393282098e-09 3.41973315130949e-08 DOWN ENSG00000151025 GPR158 G protein-coupled receptor 158 [Source:HGNC Symbol;Acc:HGNC:23689] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0051641|GO:0038023|GO:0023051|GO:0016043|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0004888|GO:0009966|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0016021|GO:0010256|GO:0007186|GO:0008277|GO:0007009|GO:0072657|GO:0034613|GO:0004930|GO:0072659|GO:1990778 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|cellular localization|signaling receptor activity|regulation of signaling|cellular component organization|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|transmembrane signaling receptor activity|regulation of signal transduction|regulation of cell communication|protein localization|cell communication|membrane organization|signal transduction|integral component of membrane|endomembrane system organization|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|plasma membrane organization|protein localization to membrane|cellular protein localization|G-protein coupled receptor activity|protein localization to plasma membrane|protein localization to cell periphery - - - - 10:25175062-25602226 129 194 195 475 501 539 1.16509963182854 1.59240763576858 1.58789833653822 3.84383441725738 3.71260505725115 4.56237612750457 1.44846853471178 4.03960520067103 -1.47968595708972 1.6204535277609e-09 3.43342935541334e-08 DOWN ENSG00000065183 WDR3 WD repeat domain 3 [Source:HGNC Symbol;Acc:HGNC:12755] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0005635|GO:0006139|GO:0034388|GO:0031965|GO:0022613|GO:0005730|GO:0003723|GO:0030684|GO:0042254|GO:0031981|GO:0042274|GO:0010467|GO:0016070|GO:0005634|GO:0006364|GO:0030686|GO:0030490|GO:0006396|GO:0030515|GO:0034660|GO:0032040|GO:0044822|GO:0000462|GO:0016072 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nuclear envelope|nucleobase-containing compound metabolic process|Pwp2p-containing subcomplex of 90S preribosome|nuclear membrane|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|preribosome|ribosome biogenesis|nuclear lumen|ribosomal small subunit biogenesis|gene expression|RNA metabolic process|nucleus|rRNA processing|90S preribosome|maturation of SSU-rRNA|RNA processing|snoRNA binding|ncRNA metabolic process|small-subunit processome|poly(A) RNA binding|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA metabolic process K14556 U3 small nucleolar RNA-associated protein 12[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 1:117929720-117966542 10354 11150 8928 4498 5010 2875 69.4358521893283 67.956421209837 53.9813832093409 27.0266834749465 27.5664797197488 18.0693423529888 63.7912188695021 24.2208351825614 1.39710923171261 1.62645030152214e-09 3.4436912979888e-08 UP ENSG00000064489 BORCS8-MEF2B BORCS8-MEF2B readthrough [Source:HGNC Symbol;Acc:HGNC:39979] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0046983|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|protein dimerization activity|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription K09261 MADS-box transcription enhancer factor 2B[-] hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) 19:19145567-19192158 2 6 23 70 101 98 0.0335389108336487 0.0914470868834559 0.347762404397236 1.05180925700672 1.38971755492331 1.5402677211999 0.15758280070478 1.32726484437664 -3.07427429064374 1.64579708716659e-09 3.48218470873646e-08 DOWN ENSG00000279267 RP11-395L14.18 - - - - - - - 2:113605867-113607908 105 109 126 27 36 43 3.63731074670728 3.43160937868582 3.93527634991415 0.838026915415531 1.02318621520752 1.3960037389784 3.66806549176908 1.08573895653382 1.75634211921368 1.67133417126242e-09 3.53371178108132e-08 UP ENSG00000178971 CTC1 CTS telomere maintenance complex component 1 [Source:HGNC Symbol;Acc:HGNC:26169] GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0030234|GO:0032993|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0004857|GO:0006725|GO:0009888|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0032204|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0043231|GO:0000723|GO:0048144|GO:0035264|GO:0042592|GO:0009890|GO:0006139|GO:0044092|GO:0060348|GO:0050790|GO:0043086|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0048732|GO:0006996|GO:0072089|GO:0007568|GO:0051276|GO:0003677|GO:0048538|GO:0034645|GO:0051053|GO:0010833|GO:1903047|GO:0030097|GO:0048536|GO:0048539|GO:0044770|GO:0000278|GO:0048145|GO:0007569|GO:0031981|GO:0007346|GO:0010521|GO:0010564|GO:0048146|GO:0006259|GO:0005694|GO:0000228|GO:0051054|GO:0033043|GO:0031328|GO:1904356|GO:0009059|GO:0001501|GO:0010557|GO:0005634|GO:0006974|GO:0071425|GO:0000783|GO:0008156|GO:0032200|GO:0006260|GO:0000781|GO:2000279|GO:0000086|GO:0051972|GO:0003697|GO:0044772|GO:0043565|GO:0033044|GO:1901990|GO:2000278|GO:1990879|GO:0006275|GO:0000784|GO:0090399|GO:1901987|GO:0045740|GO:0071897|GO:0051974|GO:0042162|GO:0010389|GO:1902749|GO:0043047|GO:0098505 developmental process|growth|macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|protein-DNA complex|developmental growth|intracellular|immune system development|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|enzyme inhibitor activity|cellular aromatic compound metabolic process|tissue development|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|regulation of telomere maintenance|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|telomere maintenance|fibroblast proliferation|multicellular organism growth|homeostatic process|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|negative regulation of molecular function|bone development|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|organelle organization|stem cell proliferation|aging|chromosome organization|DNA binding|thymus development|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|telomere maintenance via telomere lengthening|mitotic cell cycle process|hemopoiesis|spleen development|bone marrow development|cell cycle phase transition|mitotic cell cycle|regulation of fibroblast proliferation|cell aging|nuclear lumen|regulation of mitotic cell cycle|telomerase inhibitor activity|regulation of cell cycle process|positive regulation of fibroblast proliferation|DNA metabolic process|chromosome|nuclear chromosome|positive regulation of DNA metabolic process|regulation of organelle organization|positive regulation of cellular biosynthetic process|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|skeletal system development|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|hematopoietic stem cell proliferation|nuclear telomere cap complex|negative regulation of DNA replication|telomere organization|DNA replication|chromosome, telomeric region|negative regulation of DNA biosynthetic process|G2/M transition of mitotic cell cycle|regulation of telomerase activity|single-stranded DNA binding|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of chromosome organization|regulation of mitotic cell cycle phase transition|regulation of DNA biosynthetic process|CST complex|regulation of DNA replication|nuclear chromosome, telomeric region|replicative senescence|regulation of cell cycle phase transition|positive regulation of DNA replication|DNA biosynthetic process|negative regulation of telomerase activity|telomeric DNA binding|regulation of G2/M transition of mitotic cell cycle|regulation of cell cycle G2/M phase transition|single-stranded telomeric DNA binding|G-rich strand telomeric DNA binding - - - - 17:8224821-8248044 168 161 282 590 662 572 0.872715624798628 0.760100320143061 1.32077134644907 2.74608362148723 2.82156804556035 2.78477208600147 0.984529097130253 2.78414125101635 -1.49972665713547 1.69243081389288e-09 3.57578411308975e-08 DOWN ENSG00000087087 SRRT serrate, RNA effector molecule [Source:HGNC Symbol;Acc:HGNC:24101] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0046685|GO:0034641|GO:0046483|GO:0045597|GO:0043231|GO:0005737|GO:0009890|GO:0016458|GO:0006139|GO:0000166|GO:0048869|GO:0044249|GO:0019827|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0031047|GO:0010629|GO:0010720|GO:0051252|GO:0097150|GO:0032269|GO:0043331|GO:0031981|GO:0050769|GO:0005654|GO:0014070|GO:0043603|GO:0044267|GO:0010467|GO:0007399|GO:0071310|GO:0051246|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0051960|GO:0016441|GO:0043043|GO:0006396|GO:0032774|GO:0017148|GO:0034660|GO:0071359|GO:2001141|GO:0010608|GO:0071407|GO:0006412|GO:0040029|GO:0006417|GO:0035196|GO:0044822|GO:0022008|GO:0050767|GO:0006351|GO:0035194|GO:0006355|GO:0048699|GO:1903506|GO:0035195|GO:0031053 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|response to arsenic-containing substance|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|nucleotide binding|cellular developmental process|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|gene silencing by RNA|negative regulation of gene expression|positive regulation of cell development|regulation of RNA metabolic process|neuronal stem cell population maintenance|negative regulation of cellular protein metabolic process|response to dsRNA|nuclear lumen|positive regulation of neurogenesis|nucleoplasm|response to organic cyclic compound|cellular amide metabolic process|cellular protein metabolic process|gene expression|nervous system development|cellular response to organic substance|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|regulation of nervous system development|posttranscriptional gene silencing|peptide biosynthetic process|RNA processing|RNA biosynthetic process|negative regulation of translation|ncRNA metabolic process|cellular response to dsRNA|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|cellular response to organic cyclic compound|translation|regulation of gene expression, epigenetic|regulation of translation|production of miRNAs involved in gene silencing by miRNA|poly(A) RNA binding|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|posttranscriptional gene silencing by RNA|regulation of transcription, DNA-templated|generation of neurons|regulation of nucleic acid-templated transcription|gene silencing by miRNA|primary miRNA processing - - - - 7:100875111-100888664 4955 4898 3296 1826 1919 1173 41.7015035969139 37.4633707945857 25.0097544338086 13.7691285721767 13.2510728588703 9.25198222957987 34.7248762751027 12.0907278868756 1.5220684534538 1.69618573526417e-09 3.57818390927285e-08 UP ENSG00000107077 KDM4C lysine (K)-specific demethylase 4C [Source:HGNC Symbol;Acc:HGNC:17071] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032451|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:0051213|GO:1901360|GO:0016570|GO:0005102|GO:0034641|GO:0032452|GO:0046483|GO:0006482|GO:0043231|GO:0043169|GO:0019899|GO:0070988|GO:0006139|GO:0000790|GO:0007154|GO:0007165|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0055114|GO:0051276|GO:0032454|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0051427|GO:0051252|GO:0006325|GO:0036211|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0016577|GO:0035556|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0035257|GO:0070076|GO:0046914|GO:0016568|GO:0007264|GO:0006464|GO:0006351|GO:0006355|GO:0033169|GO:0006366|GO:0035258|GO:0006357|GO:1903506|GO:0008270|GO:0050681 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|demethylase activity|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|dioxygenase activity|organic cyclic compound metabolic process|histone modification|receptor binding|cellular nitrogen compound metabolic process|histone demethylase activity|heterocycle metabolic process|protein demethylation|intracellular membrane-bounded organelle|cation binding|enzyme binding|demethylation|nucleobase-containing compound metabolic process|nuclear chromatin|cell communication|signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|chromosome organization|histone demethylase activity (H3-K9 specific)|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|hormone receptor binding|regulation of RNA metabolic process|chromatin organization|protein modification process|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|histone demethylation|intracellular signal transduction|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|histone lysine demethylation|transition metal ion binding|chromatin modification|small GTPase mediated signal transduction|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|histone H3-K9 demethylation|transcription from RNA polymerase II promoter|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|zinc ion binding|androgen receptor binding - - - - 9:6757641-7175648 39 56 73 190 218 184 0.191337796254805 0.249694057180461 0.322908702540538 0.835204417119318 0.877536427145867 0.846034714801565 0.254646851991935 0.852925186355583 -1.74392131987306 1.69616435852989e-09 3.57818390927285e-08 DOWN ENSG00000223773 CD99P1 CD99 molecule pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:7083] - - - - - - X:2609348-2657229 9 12 31 90 113 83 0.0947232847802313 0.114781673106507 0.29416548693963 0.848695786338192 0.975791812369305 0.818690973643003 0.167890148275456 0.881059524116833 -2.39172191447231 1.69716232850886e-09 3.57818390927285e-08 DOWN ENSG00000185973 TMLHE trimethyllysine hydroxylase, epsilon [Source:HGNC Symbol;Acc:HGNC:18308] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0009892|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0048029|GO:0051213|GO:0006082|GO:0034641|GO:0043168|GO:0016701|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0006520|GO:0016705|GO:0043177|GO:0019842|GO:0044092|GO:0050790|GO:0043086|GO:0044249|GO:0055114|GO:0051354|GO:0046872|GO:0006577|GO:0009081|GO:0031418|GO:0009063|GO:0009437|GO:0016702|GO:0016706|GO:0005759|GO:0005739|GO:0051341|GO:0031406|GO:0009083|GO:0046395|GO:0046914|GO:0019752|GO:0045329|GO:0050353|GO:0005506|GO:0032787 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|negative regulation of metabolic process|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|monosaccharide binding|dioxygenase activity|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular amino acid metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|organic acid binding|vitamin binding|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|oxidation-reduction process|negative regulation of oxidoreductase activity|metal ion binding|amino-acid betaine metabolic process|branched-chain amino acid metabolic process|L-ascorbic acid binding|cellular amino acid catabolic process|carnitine metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|mitochondrial matrix|mitochondrion|regulation of oxidoreductase activity|carboxylic acid binding|branched-chain amino acid catabolic process|carboxylic acid catabolic process|transition metal ion binding|carboxylic acid metabolic process|carnitine biosynthetic process|trimethyllysine dioxygenase activity|iron ion binding|monocarboxylic acid metabolic process K00474 trimethyllysine dioxygenase[1.14.11.8] hsa00310 Lysine degradation - Homo sapiens (human) X:155490115-155669944 110 145 222 519 510 462 1.63776536077513 1.96204782700967 2.98007304844201 6.92349830230192 6.23015351952314 6.44662024537526 2.1932954120756 6.53342402240011 -1.57473913459107 1.7675497125034e-09 3.72395406613101e-08 DOWN ENSG00000116741 RGS2 regulator of G-protein signaling 2 [Source:HGNC Symbol;Acc:HGNC:9998] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0044089|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0048609|GO:0019222|GO:0007049|GO:0009898|GO:0014741|GO:0051130|GO:0034641|GO:0008047|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0003012|GO:0032886|GO:0098562|GO:0043005|GO:0009966|GO:1903524|GO:0010646|GO:0043085|GO:0005516|GO:0007154|GO:0044092|GO:0007276|GO:0007165|GO:0009968|GO:0008092|GO:0045932|GO:0050790|GO:0043086|GO:0048869|GO:0044249|GO:0007017|GO:0019538|GO:0031334|GO:0043254|GO:0023014|GO:0031324|GO:0031323|GO:0003013|GO:0006996|GO:0000165|GO:0005730|GO:0015631|GO:0032268|GO:0005829|GO:0007186|GO:0035150|GO:0010468|GO:0006936|GO:0034645|GO:0005096|GO:0006518|GO:0048232|GO:0043412|GO:0007010|GO:0051345|GO:0008277|GO:0070507|GO:0030695|GO:0045823|GO:0090257|GO:0045989|GO:0036211|GO:0032269|GO:0031981|GO:0045744|GO:0051346|GO:0005739|GO:0006461|GO:0006796|GO:0043603|GO:0035556|GO:0090075|GO:0032273|GO:0033043|GO:0044267|GO:0051174|GO:0010611|GO:0014896|GO:0010467|GO:1902532|GO:0051246|GO:0045986|GO:0009059|GO:0030154|GO:1902531|GO:0000226|GO:0008015|GO:0010614|GO:0005634|GO:0010638|GO:0006941|GO:0008016|GO:0007283|GO:0043043|GO:0045444|GO:0048487|GO:0006939|GO:0034622|GO:0006937|GO:0043408|GO:0031113|GO:0043951|GO:0060047|GO:0043623|GO:0043087|GO:0016310|GO:0010608|GO:0031116|GO:0071877|GO:0060452|GO:0006412|GO:0031110|GO:0043547|GO:0051493|GO:0006417|GO:0055119|GO:0031109|GO:0071875|GO:0060192|GO:0043409|GO:0033673|GO:0044557|GO:0006464|GO:0019932|GO:0051495|GO:0060087|GO:0043549|GO:0043949|GO:0050880|GO:0003300|GO:0051258|GO:0010519|GO:0045859|GO:0019935|GO:0006940|GO:0006469|GO:0010517|GO:0006468|GO:0043407|GO:0006942|GO:0042311|GO:0043405|GO:0060048|GO:0042325|GO:0001932|GO:0042326|GO:0055117|GO:0050873|GO:0046785|GO:0001933|GO:0071901|GO:0071900|GO:0019933 developmental process|reproduction|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|multicellular organismal reproductive process|regulation of metabolic process|cell cycle|cytoplasmic side of plasma membrane|negative regulation of muscle hypertrophy|positive regulation of cellular component organization|cellular nitrogen compound metabolic process|enzyme activator activity|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|muscle system process|regulation of microtubule-based process|cytoplasmic side of membrane|neuron projection|regulation of signal transduction|positive regulation of blood circulation|regulation of cell communication|positive regulation of catalytic activity|calmodulin binding|cell communication|negative regulation of molecular function|gamete generation|signal transduction|negative regulation of signal transduction|cytoskeletal protein binding|negative regulation of muscle contraction|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|microtubule-based process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|organelle organization|MAPK cascade|nucleolus|tubulin binding|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|regulation of tube size|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|GTPase activator activity|peptide metabolic process|male gamete generation|macromolecule modification|cytoskeleton organization|positive regulation of hydrolase activity|regulation of G-protein coupled receptor protein signaling pathway|regulation of microtubule cytoskeleton organization|GTPase regulator activity|positive regulation of heart contraction|regulation of muscle system process|positive regulation of striated muscle contraction|protein modification process|negative regulation of cellular protein metabolic process|nuclear lumen|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of hydrolase activity|mitochondrion|protein complex assembly|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|relaxation of muscle|positive regulation of protein polymerization|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of cardiac muscle hypertrophy|muscle hypertrophy|gene expression|negative regulation of intracellular signal transduction|regulation of protein metabolic process|negative regulation of smooth muscle contraction|macromolecule biosynthetic process|cell differentiation|regulation of intracellular signal transduction|microtubule cytoskeleton organization|blood circulation|negative regulation of cardiac muscle hypertrophy|nucleus|positive regulation of organelle organization|striated muscle contraction|regulation of heart contraction|spermatogenesis|peptide biosynthetic process|fat cell differentiation|beta-tubulin binding|smooth muscle contraction|cellular macromolecular complex assembly|regulation of muscle contraction|regulation of MAPK cascade|regulation of microtubule polymerization|negative regulation of cAMP-mediated signaling|heart contraction|cellular protein complex assembly|regulation of GTPase activity|phosphorylation|posttranscriptional regulation of gene expression|positive regulation of microtubule polymerization|regulation of adrenergic receptor signaling pathway|positive regulation of cardiac muscle contraction|translation|regulation of microtubule polymerization or depolymerization|positive regulation of GTPase activity|regulation of cytoskeleton organization|regulation of translation|relaxation of cardiac muscle|microtubule polymerization or depolymerization|adrenergic receptor signaling pathway|negative regulation of lipase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|relaxation of smooth muscle|cellular protein modification process|second-messenger-mediated signaling|positive regulation of cytoskeleton organization|relaxation of vascular smooth muscle|regulation of kinase activity|regulation of cAMP-mediated signaling|regulation of blood vessel size|cardiac muscle hypertrophy|protein polymerization|negative regulation of phospholipase activity|regulation of protein kinase activity|cyclic-nucleotide-mediated signaling|regulation of smooth muscle contraction|negative regulation of protein kinase activity|regulation of phospholipase activity|protein phosphorylation|negative regulation of MAP kinase activity|regulation of striated muscle contraction|vasodilation|regulation of MAP kinase activity|cardiac muscle contraction|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|regulation of cardiac muscle contraction|brown fat cell differentiation|microtubule polymerization|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|cAMP-mediated signaling K18154 regulator of G-protein signaling 2[-] hsa04740|hsa04022|hsa04921 Olfactory transduction - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human) 1:192809039-192812283 127 112 126 43 41 35 2.93102551079439 2.34916079375393 2.62180564650071 0.889161658980693 0.77636089614279 0.757025499256685 2.63399731701634 0.807516018126723 1.70569109314046 1.77300567213685e-09 3.73281462171887e-08 UP ENSG00000165476 REEP3 receptor accessory protein 3 [Source:HGNC Symbol;Acc:HGNC:23711] GO:0005623|GO:0016020|GO:0009987|GO:0043229|GO:0042175|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0007049|GO:0022402|GO:0005874|GO:0043231|GO:0005737|GO:0061024|GO:0005783|GO:0051301|GO:0016021|GO:0010256|GO:0006996|GO:0006998|GO:1903047|GO:0000278|GO:0007067|GO:0006997|GO:0005856|GO:0007084|GO:0031468|GO:0015630 cell|membrane|cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cell cycle|cell cycle process|microtubule|intracellular membrane-bounded organelle|cytoplasm|membrane organization|endoplasmic reticulum|cell division|integral component of membrane|endomembrane system organization|organelle organization|nuclear envelope organization|mitotic cell cycle process|mitotic cell cycle|mitotic nuclear division|nucleus organization|cytoskeleton|mitotic nuclear envelope reassembly|nuclear envelope reassembly|microtubule cytoskeleton - - - - 10:63521363-63625123 806 973 1153 2204 2580 2525 10.6428788826166 11.6766167998709 13.7267484831303 26.0755494709696 27.9519313473242 31.2474371981254 12.0154147218726 28.4249726721397 -1.24227251697932 1.81618182100134e-09 3.8210212885253e-08 DOWN ENSG00000183077 AFMID arylformamidase [Source:HGNC Symbol;Acc:HGNC:20910] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0006575|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0016810|GO:0051186|GO:0006139|GO:0055086|GO:0042180|GO:0044249|GO:0005829|GO:0009308|GO:0016811|GO:0009072|GO:0009063|GO:0006796|GO:0019439|GO:0070189|GO:0005634|GO:0006568|GO:0009074|GO:0019441|GO:0009117|GO:0046395|GO:0009108|GO:0006576|GO:0004061|GO:0019752|GO:0009165|GO:0006569|GO:0019363|GO:0034354|GO:0019674|GO:0009435 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|cellular modified amino acid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cellular ketone metabolic process|cellular biosynthetic process|cytosol|amine metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|aromatic amino acid family metabolic process|cellular amino acid catabolic process|phosphate-containing compound metabolic process|aromatic compound catabolic process|kynurenine metabolic process|nucleus|tryptophan metabolic process|aromatic amino acid family catabolic process|tryptophan catabolic process to kynurenine|nucleotide metabolic process|carboxylic acid catabolic process|coenzyme biosynthetic process|cellular biogenic amine metabolic process|arylformamidase activity|carboxylic acid metabolic process|nucleotide biosynthetic process|tryptophan catabolic process|pyridine nucleotide biosynthetic process|'de novo' NAD biosynthetic process from tryptophan|NAD metabolic process|NAD biosynthetic process K01432 arylformamidase[3.5.1.9] hsa01100|hsa00380|hsa00630 Metabolic pathways - Homo sapiens (human)|Tryptophan metabolism - Homo sapiens (human)|Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) 17:78187317-78207701 490 527 719 241 220 277 4.64812070636642 4.54330677488635 6.14928943133252 2.04830903492621 1.71226881325049 2.4625826099492 5.1135723041951 2.0743868193753 1.30164655509766 1.83526990236737e-09 3.85846110318841e-08 UP ENSG00000056998 GYG2 glycogenin 2 [Source:HGNC Symbol;Acc:HGNC:4700] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0016740|GO:0044262|GO:0015980|GO:0044281|GO:0043231|GO:0005737|GO:0005975|GO:0016757|GO:0006091|GO:0044249|GO:0055114|GO:0005829|GO:0005976|GO:0034645|GO:0008194|GO:0005773|GO:0044275|GO:0016758|GO:0033692|GO:0005977|GO:0005996|GO:0016052|GO:0006112|GO:0005775|GO:0009059|GO:0016051|GO:0005978|GO:0019318|GO:0046527|GO:0000323|GO:0000271|GO:0005980|GO:0043202|GO:0035251|GO:0000272|GO:0005764|GO:0006006|GO:0008466 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|transferase activity|cellular carbohydrate metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|generation of precursor metabolites and energy|cellular biosynthetic process|oxidation-reduction process|cytosol|polysaccharide metabolic process|cellular macromolecule biosynthetic process|UDP-glycosyltransferase activity|vacuole|cellular carbohydrate catabolic process|transferase activity, transferring hexosyl groups|cellular polysaccharide biosynthetic process|glycogen metabolic process|monosaccharide metabolic process|carbohydrate catabolic process|energy reserve metabolic process|vacuolar lumen|macromolecule biosynthetic process|carbohydrate biosynthetic process|glycogen biosynthetic process|hexose metabolic process|glucosyltransferase activity|lytic vacuole|polysaccharide biosynthetic process|glycogen catabolic process|lysosomal lumen|UDP-glucosyltransferase activity|polysaccharide catabolic process|lysosome|glucose metabolic process|glycogenin glucosyltransferase activity - - - - X:2828788-2882818 26 66 49 173 226 370 0.27536141602054 0.635269042853509 0.467888070865153 1.64164318772513 1.96386459997262 3.67253009833409 0.459506176579734 2.42601262867728 -2.4004309013249 1.85016026218314e-09 3.88702916729174e-08 DOWN ENSG00000170035 UBE2E3 ubiquitin conjugating enzyme E2E 3 [Source:HGNC Symbol;Acc:HGNC:12479] GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0040008|GO:0005622|GO:0005515|GO:0016740|GO:0043168|GO:0001882|GO:0043231|GO:0005737|GO:0019787|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0004842|GO:0001883|GO:0036211|GO:0032549|GO:0044267|GO:0017076|GO:0005634|GO:0061631|GO:0005524|GO:0030554|GO:0006464|GO:0032446|GO:0016567|GO:0000209|GO:0070534|GO:0070936|GO:0070979 growth|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|regulation of growth|intracellular|protein binding|transferase activity|anion binding|nucleoside binding|intracellular membrane-bounded organelle|cytoplasm|ubiquitin-like protein transferase activity|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|ubiquitin-protein transferase activity|purine nucleoside binding|protein modification process|ribonucleoside binding|cellular protein metabolic process|purine nucleotide binding|nucleus|ubiquitin conjugating enzyme activity|ATP binding|adenyl nucleotide binding|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination|protein polyubiquitination|protein K63-linked ubiquitination|protein K48-linked ubiquitination|protein K11-linked ubiquitination K06689 ubiquitin-conjugating enzyme E2 D/E[2.3.2.23] hsa04141|hsa04120 Protein processing in endoplasmic reticulum - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human) 2:180967248-181076585 893 1030 933 2977 2808 2038 9.8592196542746 10.3349433417758 9.28724113104743 29.4487932649365 25.4364223666776 21.087458032876 9.82713470903261 25.32422455483 -1.36567535600779 1.87342650685299e-09 3.93314169729881e-08 DOWN ENSG00000227507 LTB lymphotoxin beta [Source:HGNC Symbol;Acc:HGNC:6711] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0006955|GO:0044237|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0007275|GO:0048513|GO:0005102|GO:0031325|GO:0001817|GO:0001816|GO:0007267|GO:0001819|GO:0007154|GO:0007165|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0032735|GO:0042107|GO:0005126|GO:0042089|GO:0007166|GO:0034097|GO:0048535|GO:0032655|GO:0005125|GO:0032615|GO:0042035|GO:0051247|GO:0043588|GO:0042108|GO:0010467|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0010557|GO:0019221|GO:0045084|GO:0032813|GO:0071345|GO:0045075|GO:0034612|GO:0005164|GO:0071356|GO:0033209 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|immune response|cellular metabolic process|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|immune system development|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|multicellular organism development|animal organ development|receptor binding|positive regulation of cellular metabolic process|regulation of cytokine production|cytokine production|cell-cell signaling|positive regulation of cytokine production|cell communication|signal transduction|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|positive regulation of interleukin-12 production|cytokine metabolic process|cytokine receptor binding|cytokine biosynthetic process|cell surface receptor signaling pathway|response to cytokine|lymph node development|regulation of interleukin-12 production|cytokine activity|interleukin-12 production|regulation of cytokine biosynthetic process|positive regulation of protein metabolic process|skin development|positive regulation of cytokine biosynthetic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of macromolecule biosynthetic process|cytokine-mediated signaling pathway|positive regulation of interleukin-12 biosynthetic process|tumor necrosis factor receptor superfamily binding|cellular response to cytokine stimulus|regulation of interleukin-12 biosynthetic process|response to tumor necrosis factor|tumor necrosis factor receptor binding|cellular response to tumor necrosis factor|tumor necrosis factor-mediated signaling pathway - - - - 6:31580525-31582522 23 33 41 128 157 105 0.520964245671195 0.679318409627654 0.837271856975552 2.59766015396307 2.91769916074796 2.22889832394019 0.6791848374248 2.58141921288374 -1.92628829209214 1.89580487001244e-09 3.97732667528823e-08 DOWN ENSG00000270170 NCBP2-AS2 NCBP2 antisense RNA 2 (head to head) [Source:HGNC Symbol;Acc:HGNC:25121] - - - - - - 3:196942623-196943540 1195 1131 974 540 524 396 92.0812094221314 79.2037363021799 67.6669070635177 37.2815972547646 33.1285357618102 28.5974612819665 79.650617595943 33.0025314328471 1.27110885869295 1.90115634796451e-09 3.98575292220032e-08 UP ENSG00000106771 TMEM245 transmembrane protein 245 [Source:HGNC Symbol;Acc:HGNC:1363] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 9:109015152-109119945 541 798 1298 2427 2631 3009 2.99113752306574 4.00979583464227 6.47035919528017 12.0228363108268 11.9351604005581 15.5915930348559 4.49043085099606 13.1831965820803 -1.55377444733304 1.91765575439186e-09 4.01752244853436e-08 DOWN ENSG00000251013 GAPDHP62 glyceraldehyde 3 phosphate dehydrogenase pseudogene 62 [Source:HGNC Symbol;Acc:HGNC:4156] - - - - - - 8:100550724-100551713 47 71 36 12 6 4 3.35822536458182 4.61053421441596 2.31913446821005 0.768252758870724 0.351722223696278 0.267821193445326 3.42929801573594 0.462598725337443 2.89008008818344 1.95508881648056e-09 4.09307303837382e-08 UP ENSG00000145220 LYAR Ly1 antibody reactive [Source:HGNC Symbol;Acc:HGNC:26021] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0043169|GO:0005730|GO:0046872|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|nucleolus|metal ion binding|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 4:4267701-4290169 1383 1444 970 476 536 247 35.3940146281881 33.5857401956613 22.3817324444003 10.9147105461145 11.2548711843739 5.92424894864617 30.4538290894166 9.36461022637819 1.70133278271194 1.96014452746711e-09 4.10078169046973e-08 UP ENSG00000023608 SNAPC1 small nuclear RNA activating complex polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:11134] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0006383|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase III promoter|regulation of nucleic acid-templated transcription - - - - 14:61762357-61796428 1104 1125 1719 624 625 575 29.4026723821399 27.2301604340839 41.2769708498933 14.8901752802003 13.65733531527 14.3520703054274 32.636601222039 14.2998603002992 1.19048976982411 2.00307038013172e-09 4.18765147958349e-08 UP ENSG00000156876 SASS6 SAS-6 centriolar assembly protein [Source:HGNC Symbol;Acc:HGNC:25403] GO:0005623|GO:0009987|GO:0005488|GO:0043229|GO:0016043|GO:0005622|GO:0005515|GO:0007049|GO:0022402|GO:0022607|GO:0005737|GO:0007017|GO:0006996|GO:0031023|GO:0005813|GO:0007010|GO:0005815|GO:0007098|GO:0098534|GO:0098536|GO:0005814|GO:0007099|GO:0070925|GO:0051298|GO:0000226|GO:0005856|GO:0015630|GO:0051297 cell|cellular process|binding|intracellular organelle|cellular component organization|intracellular|protein binding|cell cycle|cell cycle process|cellular component assembly|cytoplasm|microtubule-based process|organelle organization|microtubule organizing center organization|centrosome|cytoskeleton organization|microtubule organizing center|centrosome cycle|centriole assembly|deuterosome|centriole|centriole replication|organelle assembly|centrosome duplication|microtubule cytoskeleton organization|cytoskeleton|microtubule cytoskeleton|centrosome organization - - - - 1:100083563-100132955 121 148 216 508 653 404 2.01061588275683 2.23502952964583 3.23601726321856 7.56316258272663 8.90272431106013 6.29147896091553 2.49388755854041 7.5857886182341 -1.60490275067649 2.0186393228586e-09 4.21724691005044e-08 DOWN ENSG00000049247 UTS2 urotensin 2 [Source:HGNC Symbol;Acc:HGNC:12636] GO:0040011|GO:0032502|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0042752|GO:0048523|GO:0008283|GO:0007622|GO:0050794|GO:0040012|GO:0006950|GO:0007623|GO:0048520|GO:0071704|GO:0009628|GO:0051051|GO:0051641|GO:0050795|GO:0042753|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0044708|GO:0023057|GO:0009893|GO:0009058|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0060341|GO:0008284|GO:0051272|GO:0042127|GO:0003014|GO:0050804|GO:0045595|GO:0006810|GO:0001568|GO:0007275|GO:0003105|GO:0005102|GO:0032940|GO:0010841|GO:2000147|GO:0030431|GO:0050806|GO:0045597|GO:0048144|GO:0005737|GO:0003012|GO:0007267|GO:0032880|GO:0006928|GO:0042592|GO:1903524|GO:0045184|GO:0046883|GO:0019725|GO:0042493|GO:0044236|GO:0010646|GO:0001525|GO:0035814|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0046888|GO:2000021|GO:0009725|GO:0007588|GO:0001666|GO:0008217|GO:0051048|GO:1903531|GO:0002027|GO:0010817|GO:0048869|GO:2000145|GO:0048512|GO:0010033|GO:0051224|GO:0050878|GO:0003013|GO:0005829|GO:0044259|GO:0035150|GO:0006936|GO:0010712|GO:0090276|GO:0032224|GO:0033993|GO:0003071|GO:0001944|GO:0097205|GO:0072358|GO:0032964|GO:0048878|GO:0045187|GO:0005179|GO:0050709|GO:0051223|GO:0045823|GO:0015031|GO:0035813|GO:0044062|GO:0030334|GO:0001667|GO:0046005|GO:0070201|GO:0010459|GO:0042886|GO:0055082|GO:0048145|GO:0045766|GO:0051046|GO:0045765|GO:0045776|GO:0045777|GO:0009914|GO:0009306|GO:0048146|GO:0042747|GO:0045822|GO:0014070|GO:1901342|GO:0002792|GO:0046903|GO:0009059|GO:0030154|GO:0030335|GO:0010714|GO:0042745|GO:0010460|GO:0072359|GO:0008015|GO:0010557|GO:0045909|GO:0048545|GO:0097305|GO:0010840|GO:0003073|GO:0022410|GO:0050796|GO:0008016|GO:0002790|GO:0003093|GO:0030073|GO:0042312|GO:0046676|GO:0042320|GO:0060047|GO:0010763|GO:0050708|GO:0015833|GO:0032967|GO:0010762|GO:0035811|GO:0050801|GO:0033574|GO:0003094|GO:0046879|GO:0010761|GO:0006873|GO:0032963|GO:0050880|GO:0030072|GO:0042311|GO:0030003|GO:0007268|GO:0007271|GO:0055065|GO:0006875|GO:0006874|GO:0055074|GO:0055078|GO:0051480|GO:0007204 locomotion|developmental process|behavior|signaling|cell|rhythmic process|cellular process|extracellular region|metabolic process|response to stimulus|binding|regulation of circadian rhythm|negative regulation of cellular process|cell proliferation|rhythmic behavior|regulation of cellular process|regulation of locomotion|response to stress|circadian rhythm|positive regulation of behavior|organic substance metabolic process|response to abiotic stimulus|negative regulation of transport|cellular localization|regulation of behavior|positive regulation of circadian rhythm|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|single-organism behavior|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|extracellular space|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|renal system process|modulation of synaptic transmission|regulation of cell differentiation|transport|blood vessel development|multicellular organism development|negative regulation of glomerular filtration|receptor binding|secretion by cell|positive regulation of circadian sleep/wake cycle, wakefulness|positive regulation of cell motility|sleep|positive regulation of synaptic transmission|positive regulation of cell differentiation|fibroblast proliferation|cytoplasm|muscle system process|cell-cell signaling|regulation of protein localization|movement of cell or subcellular component|homeostatic process|positive regulation of blood circulation|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|response to drug|multicellular organism metabolic process|regulation of cell communication|angiogenesis|negative regulation of renal sodium excretion|protein localization|cell communication|regulation of cellular component movement|cell migration|negative regulation of hormone secretion|regulation of ion homeostasis|response to hormone|excretion|response to hypoxia|regulation of blood pressure|negative regulation of secretion|negative regulation of secretion by cell|regulation of heart rate|regulation of hormone levels|cellular developmental process|regulation of cell motility|circadian behavior|response to organic substance|negative regulation of protein transport|regulation of body fluid levels|circulatory system process|cytosol|multicellular organismal macromolecule metabolic process|regulation of tube size|muscle contraction|regulation of collagen metabolic process|regulation of peptide hormone secretion|positive regulation of synaptic transmission, cholinergic|response to lipid|renal system process involved in regulation of systemic arterial blood pressure|vasculature development|renal filtration|cardiovascular system development|collagen biosynthetic process|chemical homeostasis|regulation of circadian sleep/wake cycle, sleep|hormone activity|negative regulation of protein secretion|regulation of protein transport|positive regulation of heart contraction|protein transport|regulation of renal sodium excretion|regulation of excretion|regulation of cell migration|ameboidal-type cell migration|positive regulation of circadian sleep/wake cycle, REM sleep|regulation of establishment of protein localization|negative regulation of heart rate|amide transport|cellular chemical homeostasis|regulation of fibroblast proliferation|positive regulation of angiogenesis|regulation of secretion|regulation of angiogenesis|negative regulation of blood pressure|positive regulation of blood pressure|hormone transport|protein secretion|positive regulation of fibroblast proliferation|circadian sleep/wake cycle, REM sleep|negative regulation of heart contraction|response to organic cyclic compound|regulation of vasculature development|negative regulation of peptide secretion|secretion|macromolecule biosynthetic process|cell differentiation|positive regulation of cell migration|positive regulation of collagen metabolic process|circadian sleep/wake cycle|positive regulation of heart rate|circulatory system development|blood circulation|positive regulation of macromolecule biosynthetic process|positive regulation of vasodilation|response to steroid hormone|response to alcohol|regulation of circadian sleep/wake cycle, wakefulness|regulation of systemic arterial blood pressure|circadian sleep/wake cycle process|regulation of insulin secretion|regulation of heart contraction|peptide secretion|regulation of glomerular filtration|insulin secretion|regulation of vasodilation|negative regulation of insulin secretion|regulation of circadian sleep/wake cycle, REM sleep|heart contraction|positive regulation of fibroblast migration|regulation of protein secretion|peptide transport|positive regulation of collagen biosynthetic process|regulation of fibroblast migration|negative regulation of urine volume|ion homeostasis|response to testosterone|glomerular filtration|hormone secretion|fibroblast migration|cellular ion homeostasis|collagen metabolic process|regulation of blood vessel size|peptide hormone secretion|vasodilation|cellular cation homeostasis|synaptic transmission|synaptic transmission, cholinergic|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis|sodium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration - - - - 1:7843083-7853512 9 15 16 55 76 69 0.2804560339242 0.424819363807891 0.449536930373311 1.53561705553209 1.94312215502026 2.01510157051355 0.384937442701801 1.8312802603553 -2.25015668562396 2.06893937629532e-09 4.31930882097346e-08 DOWN ENSG00000174013 FBXO45 F-box protein 45 [Source:HGNC Symbol;Acc:HGNC:29148] GO:0040011|GO:0032502|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0060076|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0048870|GO:0009653|GO:0016043|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0048468|GO:0007275|GO:0048513|GO:0030900|GO:0033554|GO:0045211|GO:0007420|GO:0022607|GO:0042734|GO:0060322|GO:0021987|GO:0006928|GO:0014069|GO:0060384|GO:0016477|GO:0050808|GO:0021675|GO:0021543|GO:0030030|GO:0048869|GO:0021537|GO:0019538|GO:0000902|GO:0031175|GO:0022029|GO:0007416|GO:0043412|GO:0030163|GO:0060386|GO:0007417|GO:0044265|GO:0000904|GO:0021885|GO:0036211|GO:0001764|GO:0006508|GO:0021960|GO:0021795|GO:0044267|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0006974|GO:0048666|GO:0030182|GO:0021953|GO:0044257|GO:0021800|GO:0010498|GO:0021799|GO:0061564|GO:0051603|GO:0021954|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0021955|GO:0007409|GO:0019941|GO:0048699|GO:0043161|GO:0032446|GO:0021952|GO:0006511|GO:0042787|GO:0016567|GO:0021957 locomotion|developmental process|synapse|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|excitatory synapse|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cell motility|anatomical structure morphogenesis|cellular component organization|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|synaptic membrane|cell development|multicellular organism development|animal organ development|forebrain development|cellular response to stress|postsynaptic membrane|brain development|cellular component assembly|presynaptic membrane|head development|cerebral cortex development|movement of cell or subcellular component|postsynaptic density|innervation|cell migration|synapse organization|nerve development|pallium development|cell projection organization|cellular developmental process|telencephalon development|protein metabolic process|cell morphogenesis|neuron projection development|telencephalon cell migration|synapse assembly|macromolecule modification|protein catabolic process|synapse assembly involved in innervation|central nervous system development|cellular macromolecule catabolic process|cell morphogenesis involved in differentiation|forebrain cell migration|protein modification process|neuron migration|proteolysis|anterior commissure morphogenesis|cerebral cortex cell migration|cellular protein metabolic process|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|cellular response to DNA damage stimulus|neuron development|neuron differentiation|central nervous system neuron differentiation|cellular protein catabolic process|cerebral cortex tangential migration|proteasomal protein catabolic process|cerebral cortex radially oriented cell migration|axon development|proteolysis involved in cellular protein catabolic process|central nervous system neuron development|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|central nervous system neuron axonogenesis|axonogenesis|modification-dependent protein catabolic process|generation of neurons|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|central nervous system projection neuron axonogenesis|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|corticospinal tract morphogenesis - - - - 3:196568611-196589059 2516 2895 2853 1403 1492 1076 19.2800267572522 20.1616307378211 19.7111988503613 9.6327976070338 9.38066986550642 7.72748539201882 19.7176187818115 8.91365095485301 1.1453969603044 2.08487826188997e-09 4.34954267159072e-08 UP ENSG00000143514 TP53BP2 tumor protein p53 binding protein 2 [Source:HGNC Symbol;Acc:HGNC:12000] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0005622|GO:0005515|GO:0042802|GO:0035591|GO:0051726|GO:0007049|GO:0010941|GO:0002039|GO:0097194|GO:0010942|GO:0045786|GO:0043231|GO:0005737|GO:0009966|GO:0030674|GO:0019904|GO:0010646|GO:0007154|GO:0007165|GO:0008134|GO:0008219|GO:0009967|GO:0017124|GO:1901216|GO:0070997|GO:1900117|GO:0048471|GO:0051059|GO:1901214|GO:0012501|GO:0035556|GO:1900119|GO:0043068|GO:0005070|GO:0005634|GO:0043067|GO:0097190|GO:0097193|GO:0043065|GO:0072331|GO:0042981|GO:0006915|GO:0072332 signaling|cell|cellular process|response to stimulus|binding|binding, bridging|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|intracellular|protein binding|identical protein binding|signaling adaptor activity|regulation of cell cycle|cell cycle|regulation of cell death|p53 binding|execution phase of apoptosis|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|protein binding, bridging|protein domain specific binding|regulation of cell communication|cell communication|signal transduction|transcription factor binding|cell death|positive regulation of signal transduction|SH3 domain binding|positive regulation of neuron death|neuron death|regulation of execution phase of apoptosis|perinuclear region of cytoplasm|NF-kappaB binding|regulation of neuron death|programmed cell death|intracellular signal transduction|positive regulation of execution phase of apoptosis|positive regulation of programmed cell death|SH3/SH2 adaptor activity|nucleus|regulation of programmed cell death|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of apoptotic process|signal transduction by p53 class mediator|regulation of apoptotic process|apoptotic process|intrinsic apoptotic signaling pathway by p53 class mediator K16823 apoptosis-stimulating of p53 protein 2[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) 1:223779899-223845972 600 572 845 1614 1904 1679 4.45306112657286 3.85818881948835 5.65429499485587 10.7326863628141 11.5942364592522 11.6784942614383 4.65518164697236 11.3351390278349 -1.28389271763301 2.10508597612964e-09 4.3886338499563e-08 DOWN ENSG00000228492 RAB11FIP1P1 RAB11 family interacting protein 1 (class I) pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:42366] - - - - - - X:74202834-74204595 15 3 21 80 89 90 0.602177397671353 0.109473513561338 0.760105401676569 2.87756858905258 2.93156563209302 3.38620474929004 0.49058543763642 3.06511299014521 -2.64336394218274 2.1189838435922e-09 4.41452502907198e-08 DOWN ENSG00000260342 RP11-1035H13.3 - GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0043234|GO:0012505|GO:0031090|GO:0006810|GO:0034641|GO:0030867|GO:0043231|GO:0005737|GO:0030529|GO:0045184|GO:0008104|GO:0061024|GO:0005783|GO:0051649|GO:0016021|GO:0044249|GO:0019538|GO:0034645|GO:0090150|GO:0006518|GO:0005840|GO:0015031|GO:0046907|GO:0005791|GO:0072657|GO:0034613|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0005784|GO:0043043|GO:0006605|GO:0006412|GO:0006886|GO:0006612|GO:0006613 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein complex|endomembrane system|organelle membrane|transport|cellular nitrogen compound metabolic process|rough endoplasmic reticulum membrane|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|establishment of protein localization|protein localization|membrane organization|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|peptide metabolic process|ribosome|protein transport|intracellular transport|rough endoplasmic reticulum|protein localization to membrane|cellular protein localization|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|Sec61 translocon complex|peptide biosynthetic process|protein targeting|translation|intracellular protein transport|protein targeting to membrane|cotranslational protein targeting to membrane - - - - 16:18788063-18801519 643 382 439 90 29 130 59.5337280046602 32.143730685236 36.6464188073861 7.46607903138611 2.20298170472525 11.2803725790044 42.7746258324274 6.98314443837192 2.61480651626836 2.12265207993294e-09 4.41908334688411e-08 UP ENSG00000101871 MID1 midline 1 [Source:HGNC Symbol;Acc:HGNC:7095] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0009893|GO:0031224|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042802|GO:0051219|GO:0045087|GO:0007275|GO:0005874|GO:0006952|GO:0031325|GO:0051128|GO:0033554|GO:0043169|GO:0019899|GO:0005737|GO:0007389|GO:0032886|GO:0032403|GO:0009966|GO:0046983|GO:0010646|GO:0005875|GO:0008104|GO:0007154|GO:0007165|GO:0008092|GO:0016021|GO:0009967|GO:0007017|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0006996|GO:0000165|GO:1902533|GO:0015631|GO:0032268|GO:0005829|GO:0046872|GO:0007166|GO:0043412|GO:0007010|GO:0034097|GO:0070507|GO:0046982|GO:0008017|GO:0036211|GO:0034341|GO:0031098|GO:0043242|GO:0051247|GO:0043244|GO:0034613|GO:0032270|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0071310|GO:0051246|GO:0005881|GO:1902531|GO:0000226|GO:0005856|GO:0042803|GO:0005819|GO:0044389|GO:0031625|GO:0043241|GO:0070304|GO:0019221|GO:0033365|GO:0031401|GO:0071346|GO:0043408|GO:0016310|GO:0031110|GO:0051494|GO:0051493|GO:0015630|GO:0043410|GO:0031109|GO:0032872|GO:0071345|GO:1901879|GO:0046914|GO:0006464|GO:0051403|GO:0007019|GO:0060333|GO:0006468|GO:0007026|GO:0043624|GO:0031111|GO:0042325|GO:0044380|GO:0001932|GO:0032874|GO:0001934|GO:0008270|GO:0042327|GO:0051261|GO:0035372 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|positive regulation of metabolic process|intrinsic component of membrane|ligase activity|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|identical protein binding|phosphoprotein binding|innate immune response|multicellular organism development|microtubule|defense response|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cation binding|enzyme binding|cytoplasm|pattern specification process|regulation of microtubule-based process|protein complex binding|regulation of signal transduction|protein dimerization activity|regulation of cell communication|microtubule associated complex|protein localization|cell communication|signal transduction|cytoskeletal protein binding|integral component of membrane|positive regulation of signal transduction|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|organelle organization|MAPK cascade|positive regulation of intracellular signal transduction|tubulin binding|regulation of cellular protein metabolic process|cytosol|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|cytoskeleton organization|response to cytokine|regulation of microtubule cytoskeleton organization|protein heterodimerization activity|microtubule binding|protein modification process|response to interferon-gamma|stress-activated protein kinase signaling cascade|negative regulation of protein complex disassembly|positive regulation of protein metabolic process|regulation of protein complex disassembly|cellular protein localization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of protein metabolic process|cytoplasmic microtubule|regulation of intracellular signal transduction|microtubule cytoskeleton organization|cytoskeleton|protein homodimerization activity|spindle|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|protein complex disassembly|positive regulation of stress-activated protein kinase signaling cascade|cytokine-mediated signaling pathway|protein localization to organelle|positive regulation of protein modification process|cellular response to interferon-gamma|regulation of MAPK cascade|phosphorylation|regulation of microtubule polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|microtubule cytoskeleton|positive regulation of MAPK cascade|microtubule polymerization or depolymerization|regulation of stress-activated MAPK cascade|cellular response to cytokine stimulus|regulation of protein depolymerization|transition metal ion binding|cellular protein modification process|stress-activated MAPK cascade|microtubule depolymerization|interferon-gamma-mediated signaling pathway|protein phosphorylation|negative regulation of microtubule depolymerization|cellular protein complex disassembly|negative regulation of microtubule polymerization or depolymerization|regulation of phosphorylation|protein localization to cytoskeleton|regulation of protein phosphorylation|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|zinc ion binding|positive regulation of phosphorylation|protein depolymerization|protein localization to microtubule K08285 midline 1[2.3.2.27] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) X:10445310-10833654 274 347 495 900 1071 994 1.10633734237581 1.27334461134168 1.80200361801196 3.25594176607055 3.54808292023713 3.76141796707853 1.39389519057648 3.5218142177954 -1.33719671983374 2.13150447054131e-09 4.43442052010734e-08 DOWN ENSG00000189180 ZNF33A zinc finger protein 33A [Source:HGNC Symbol;Acc:HGNC:13096] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 10:38010650-38065088 179 178 176 497 527 495 0.615161588970858 0.555951016376348 0.545336936209815 1.53035154229695 1.48598976780576 1.59430277090287 0.572149847185674 1.53688136033519 -1.42554085407019 2.13732587433764e-09 4.4434350036543e-08 DOWN ENSG00000260743 RP11-255C15.3 - - - - - - - 3:179340322-179341887 20 32 21 2 0 4 0.903408377977138 1.31366134516617 0.855239921937493 0.0809461719116663 0 0.169312248729804 1.02410321502693 0.0834194735471568 3.61783310802875 2.20837469737398e-09 4.58794837963833e-08 UP ENSG00000149346 SLX4IP SLX4 interacting protein [Source:HGNC Symbol;Acc:HGNC:16225] GO:0005488|GO:0005515 binding|protein binding - - - - 20:10435303-10636829 165 194 211 531 544 489 1.79784366982638 1.92109313052056 2.0728283819102 5.18393571557585 4.86332983501054 4.99350268965303 1.93058839408571 5.01358941341314 -1.37680324072757 2.24935562480138e-09 4.66983747029349e-08 DOWN ENSG00000116138 DNAJC16 DnaJ heat shock protein family (Hsp40) member C16 [Source:HGNC Symbol;Acc:HGNC:29157] GO:0005623|GO:0016020|GO:0009987|GO:0050794|GO:0031224|GO:0042592|GO:0019725|GO:0016021|GO:0045454 cell|membrane|cellular process|regulation of cellular process|intrinsic component of membrane|homeostatic process|cellular homeostasis|integral component of membrane|cell redox homeostasis - - - - 1:15526813-15592379 77 107 180 389 409 483 0.339740285699217 0.42906510398692 0.716054289296 1.53782124416218 1.48064063900873 1.9972576392347 0.494953226327379 1.67190650746854 -1.75613007424487 2.25601657237714e-09 4.68041131005887e-08 DOWN ENSG00000129518 EAPP E2F-associated phosphoprotein [Source:HGNC Symbol;Acc:HGNC:19312] GO:0005623|GO:0009987|GO:0008152|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0012505|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0005794|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0010628|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0032784|GO:1903507|GO:0032785|GO:0032786|GO:0006357|GO:1903506|GO:0006354|GO:0000122|GO:0006368|GO:0032968|GO:0034243|GO:0034244 cell|cellular process|metabolic process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|endomembrane system|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|negative regulation of nucleic acid-templated transcription|negative regulation of DNA-templated transcription, elongation|positive regulation of DNA-templated transcription, elongation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|DNA-templated transcription, elongation|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter - - - - 14:34515929-34539711 1626 1535 1324 699 743 585 31.6070735066164 27.1176589213138 23.2041599747115 12.1741437741672 11.8500630017904 10.6573307781651 27.3096308008806 11.5605125180409 1.24020445144473 2.27868369914988e-09 4.72415438572365e-08 UP ENSG00000234062 RP11-308D16.2 - - - - - - - X:136909395-137021630 24 27 37 103 116 126 0.387507822804122 0.396208075962736 0.53863377076045 1.49007153726588 1.53673324180283 1.90665639553721 0.440783223175769 1.64448705820197 -1.89949643540317 2.28028098077768e-09 4.72418517696993e-08 DOWN ENSG00000188596 CFAP54 cilia and flagella associated 54 [Source:HGNC Symbol;Acc:HGNC:26456] GO:0040011|GO:0032502|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0042995|GO:0043229|GO:0044702|GO:0019953|GO:0048870|GO:0009653|GO:0016043|GO:0032504|GO:0031224|GO:0005622|GO:0048856|GO:0005929|GO:0048646|GO:0048609|GO:0001539|GO:0005930|GO:0022607|GO:0006928|GO:0007276|GO:0030030|GO:0048869|GO:0016021|GO:0007017|GO:0060294|GO:0006996|GO:0000902|GO:0048232|GO:0060285|GO:0044782|GO:0030031|GO:0007018|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0005856|GO:0060271|GO:0007283|GO:0003341 locomotion|developmental process|reproduction|cell|membrane|cellular process|reproductive process|cell projection|intracellular organelle|single organism reproductive process|sexual reproduction|cell motility|anatomical structure morphogenesis|cellular component organization|multicellular organism reproduction|intrinsic component of membrane|intracellular|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|cilium or flagellum-dependent cell motility|axoneme|cellular component assembly|movement of cell or subcellular component|gamete generation|cell projection organization|cellular developmental process|integral component of membrane|microtubule-based process|cilium movement involved in cell motility|organelle organization|cell morphogenesis|male gamete generation|cilium-dependent cell motility|cilium organization|cell projection assembly|microtubule-based movement|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|cytoskeleton|cilium morphogenesis|spermatogenesis|cilium movement - - - - 12:96489571-96875555 13 15 20 65 83 72 0.0643190493670417 0.0674505110053796 0.0892187899513374 0.288144024894324 0.336934708046419 0.333855899922985 0.0736627834412529 0.319644877621243 -2.11746215709147 2.30179438845743e-09 4.7654486597093e-08 DOWN ENSG00000047634 SCML1 sex comb on midleg-like 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:10580] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:17737449-17754988 699 770 1179 326 385 439 5.27413829370713 5.28013690135459 8.02051778428693 2.20388828261287 2.38343407744563 3.10433163646284 6.19159765978288 2.56388466550711 1.2719803610016 2.31029627489312e-09 4.77973561958831e-08 UP ENSG00000164284 GRPEL2 GrpE-like 2, mitochondrial (E. coli) [Source:HGNC Symbol;Acc:HGNC:21060] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0006457|GO:0043227|GO:0030234|GO:0005622|GO:0005515|GO:0031090|GO:0019222|GO:0042802|GO:0019866|GO:0006810|GO:0043231|GO:0051087|GO:0005737|GO:0046983|GO:0031966|GO:0045184|GO:0008104|GO:0051649|GO:0051082|GO:0050790|GO:0000166|GO:0019538|GO:0006996|GO:0005740|GO:0072594|GO:0007005|GO:0015031|GO:0046907|GO:0005743|GO:0005759|GO:0005739|GO:0034613|GO:0044267|GO:0017076|GO:0006626|GO:0060590|GO:0042803|GO:0033365|GO:0006839|GO:0030554|GO:0006605|GO:0072655|GO:0006886|GO:0000774|GO:0070585 cell|membrane|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|protein folding|membrane-bounded organelle|enzyme regulator activity|intracellular|protein binding|organelle membrane|regulation of metabolic process|identical protein binding|organelle inner membrane|transport|intracellular membrane-bounded organelle|chaperone binding|cytoplasm|protein dimerization activity|mitochondrial membrane|establishment of protein localization|protein localization|establishment of localization in cell|unfolded protein binding|regulation of catalytic activity|nucleotide binding|protein metabolic process|organelle organization|mitochondrial envelope|establishment of protein localization to organelle|mitochondrion organization|protein transport|intracellular transport|mitochondrial inner membrane|mitochondrial matrix|mitochondrion|cellular protein localization|cellular protein metabolic process|purine nucleotide binding|protein targeting to mitochondrion|ATPase regulator activity|protein homodimerization activity|protein localization to organelle|mitochondrial transport|adenyl nucleotide binding|protein targeting|establishment of protein localization to mitochondrion|intracellular protein transport|adenyl-nucleotide exchange factor activity|protein localization to mitochondrion - - - - 5:149345430-149354583 1456 1719 1625 777 781 805 19.2402089372032 20.6445029697758 19.3604765900118 9.19956799198644 8.46773656805319 9.96949824777718 19.7483961656636 9.2122676026056 1.10010726689538 2.35786743552364e-09 4.87477662189216e-08 UP ENSG00000183020 AP2A2 adaptor related protein complex 2, alpha 2 subunit [Source:HGNC Symbol;Acc:HGNC:562] GO:0040011|GO:0032502|GO:0032991|GO:0005215|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0048523|GO:0044877|GO:0050794|GO:0019882|GO:0043229|GO:0006950|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0008289|GO:0071944|GO:0009607|GO:0009605|GO:0023057|GO:0005905|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0016032|GO:0030119|GO:0006935|GO:0008565|GO:0048468|GO:0019884|GO:0006810|GO:0098797|GO:0007275|GO:0050688|GO:0006952|GO:0031982|GO:0030276|GO:0030117|GO:0098542|GO:0043231|GO:0019899|GO:0005774|GO:0005737|GO:0007267|GO:0012506|GO:0006928|GO:0032403|GO:0009615|GO:0030666|GO:0009966|GO:0045184|GO:0030674|GO:0010646|GO:0008104|GO:0030132|GO:0007154|GO:0007165|GO:0009968|GO:0051649|GO:0002504|GO:0051607|GO:0010008|GO:0048002|GO:0030030|GO:0048869|GO:0010033|GO:0005768|GO:0016192|GO:0000902|GO:0005829|GO:0031175|GO:0036020|GO:0007166|GO:0031410|GO:0030131|GO:0015031|GO:0000904|GO:0005773|GO:0016023|GO:0030665|GO:0046907|GO:0036019|GO:1901184|GO:0070848|GO:0031988|GO:1901185|GO:0034613|GO:0019900|GO:0030118|GO:0030669|GO:0030659|GO:0030122|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0030154|GO:0048858|GO:0030120|GO:0035615|GO:0050690|GO:0002495|GO:0048666|GO:0030182|GO:0007411|GO:0030139|GO:0000323|GO:0042058|GO:0030125|GO:0071363|GO:0038179|GO:0061564|GO:0006886|GO:0007167|GO:0030135|GO:0019886|GO:0042059|GO:0030128|GO:0006897|GO:0019901|GO:0022008|GO:0048667|GO:0048812|GO:0005765|GO:0048011|GO:0030136|GO:0007409|GO:0005764|GO:0048699|GO:0006898|GO:0045334|GO:0007268|GO:0007169|GO:0072583|GO:0048013|GO:0038127|GO:0007173 locomotion|developmental process|macromolecular complex|transporter activity|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|binding, bridging|cellular response to stimulus|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|antigen processing and presentation|intracellular organelle|response to stress|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|lipid binding|cell periphery|response to biotic stimulus|response to external stimulus|negative regulation of signaling|coated pit|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|viral process|AP-type membrane coat adaptor complex|chemotaxis|protein transporter activity|cell development|antigen processing and presentation of exogenous antigen|transport|plasma membrane protein complex|multicellular organism development|regulation of defense response to virus|defense response|vesicle|clathrin binding|membrane coat|defense response to other organism|intracellular membrane-bounded organelle|enzyme binding|vacuolar membrane|cytoplasm|cell-cell signaling|vesicle membrane|movement of cell or subcellular component|protein complex binding|response to virus|endocytic vesicle membrane|regulation of signal transduction|establishment of protein localization|protein binding, bridging|regulation of cell communication|protein localization|clathrin coat of coated pit|cell communication|signal transduction|negative regulation of signal transduction|establishment of localization in cell|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|defense response to virus|endosome membrane|antigen processing and presentation of peptide antigen|cell projection organization|cellular developmental process|response to organic substance|endosome|vesicle-mediated transport|cell morphogenesis|cytosol|neuron projection development|endolysosome membrane|cell surface receptor signaling pathway|cytoplasmic vesicle|clathrin adaptor complex|protein transport|cell morphogenesis involved in differentiation|vacuole|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|intracellular transport|endolysosome|regulation of ERBB signaling pathway|response to growth factor|membrane-bounded vesicle|negative regulation of ERBB signaling pathway|cellular protein localization|kinase binding|clathrin coat|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle membrane|AP-2 adaptor complex|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|cell differentiation|cell projection morphogenesis|vesicle coat|clathrin adaptor activity|regulation of defense response to virus by virus|antigen processing and presentation of peptide antigen via MHC class II|neuron development|neuron differentiation|axon guidance|endocytic vesicle|lytic vacuole|regulation of epidermal growth factor receptor signaling pathway|clathrin vesicle coat|cellular response to growth factor stimulus|neurotrophin signaling pathway|axon development|intracellular protein transport|enzyme linked receptor protein signaling pathway|coated vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class II|negative regulation of epidermal growth factor receptor signaling pathway|clathrin coat of endocytic vesicle|endocytosis|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|lysosomal membrane|neurotrophin TRK receptor signaling pathway|clathrin-coated vesicle|axonogenesis|lysosome|generation of neurons|receptor-mediated endocytosis|clathrin-coated endocytic vesicle|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|clathrin-mediated endocytosis|ephrin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K11824 AP-2 complex subunit alpha[-] hsa04144|hsa05016|hsa04721|hsa04961 Endocytosis - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Synaptic vesicle cycle - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) 11:924894-1012245 315 314 534 976 1035 1208 1.31519887695549 1.19148936682964 2.01018840973004 3.65113895899381 3.54559782954672 4.72690734928526 1.50562555117172 3.97454804594193 -1.40042780129586 2.38085025650493e-09 4.91888605935628e-08 DOWN ENSG00000143653 SCCPDH saccharopine dehydrogenase (putative) [Source:HGNC Symbol;Acc:HGNC:24275] GO:0005623|GO:0016020|GO:0008152|GO:0003824|GO:0030496|GO:0016491|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0055114|GO:0005811|GO:0005739|GO:0005634 cell|membrane|metabolic process|catalytic activity|midbody|oxidoreductase activity|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|oxidation-reduction process|lipid particle|mitochondrion|nucleus - - - - 1:246724047-246768137 237 309 382 800 851 764 6.6978091968148 7.93639902800253 9.7333660118102 20.2568721109639 19.7325114419598 20.235180174236 8.12252474554251 20.0748545757199 -1.30538939785878 2.41735054383026e-09 4.9908425404916e-08 DOWN ENSG00000132613 MTSS1L metastasis suppressor 1-like [Source:HGNC Symbol;Acc:HGNC:25094] GO:0009987|GO:0005488|GO:0016043|GO:0005515|GO:0061024|GO:0008092|GO:0010256|GO:0003779|GO:0007009 cellular process|binding|cellular component organization|protein binding|membrane organization|cytoskeletal protein binding|endomembrane system organization|actin binding|plasma membrane organization - - - - 16:70661204-70686066 1998 2150 2931 1081 1293 1076 22.2255415323753 21.7357889633506 29.3959162048626 10.774077897979 11.801129057275 11.2175527054137 24.4524155668628 11.2642532202226 1.11822531969893 2.43632007403621e-09 5.02604988526054e-08 UP ENSG00000151332 MBIP MAP3K12 binding inhibitory protein 1 [Source:HGNC Symbol;Acc:HGNC:20427] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0023057|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0042802|GO:0051726|GO:0007049|GO:0004857|GO:0016570|GO:0033554|GO:0043231|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0006970|GO:0050790|GO:0019207|GO:0043086|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0006996|GO:0000165|GO:0051276|GO:0005730|GO:0032268|GO:0019210|GO:0043412|GO:0000173|GO:0019887|GO:0006325|GO:0016573|GO:0036211|GO:0032269|GO:0047484|GO:0031981|GO:1990234|GO:0071470|GO:0005654|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:1902532|GO:0000123|GO:0051246|GO:1902531|GO:0007231|GO:0005634|GO:0043408|GO:0043966|GO:0016310|GO:1904030|GO:0004860|GO:0005671|GO:0043409|GO:0016568|GO:0033673|GO:0006464|GO:0043549|GO:0045859|GO:0006469|GO:0006468|GO:0043407|GO:0043405|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:0001933|GO:0071901|GO:0000188|GO:0071900|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of signaling|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|identical protein binding|regulation of cell cycle|cell cycle|enzyme inhibitor activity|histone modification|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|response to osmotic stress|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|MAPK cascade|chromosome organization|nucleolus|regulation of cellular protein metabolic process|kinase inhibitor activity|macromolecule modification|inactivation of MAPK activity involved in osmosensory signaling pathway|protein kinase regulator activity|chromatin organization|histone acetylation|protein modification process|negative regulation of cellular protein metabolic process|regulation of response to osmotic stress|nuclear lumen|transferase complex|cellular response to osmotic stress|nucleoplasm|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|negative regulation of intracellular signal transduction|histone acetyltransferase complex|regulation of protein metabolic process|regulation of intracellular signal transduction|osmosensory signaling pathway|nucleus|regulation of MAPK cascade|histone H3 acetylation|phosphorylation|negative regulation of cyclin-dependent protein kinase activity|protein kinase inhibitor activity|Ada2/Gcn5/Ada3 transcription activator complex|negative regulation of MAPK cascade|chromatin modification|negative regulation of kinase activity|cellular protein modification process|regulation of kinase activity|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|negative regulation of MAP kinase activity|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|inactivation of MAPK activity|regulation of protein serine/threonine kinase activity|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation - - - - 14:36298558-36320676 992 942 1000 483 504 469 9.70015775934141 8.37139886754205 8.8161989615524 4.23166904321294 4.04357953688072 4.2980222564863 8.96258519614529 4.19109027885999 1.09658932937654 2.437770561351e-09 5.02604988526054e-08 UP ENSG00000148337 CIZ1 CDKN1A interacting zinc finger protein 1 [Source:HGNC Symbol;Acc:HGNC:16744] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0051651|GO:0030332|GO:0006139|GO:0008104|GO:0044249|GO:0031323|GO:0034645|GO:0046872|GO:0032507|GO:0006259|GO:0034613|GO:0051054|GO:0031328|GO:0009059|GO:0010557|GO:0005634|GO:0006270|GO:0033365|GO:0006260|GO:0006275|GO:0046914|GO:0045740|GO:0006261|GO:2000105|GO:0051457|GO:0030174|GO:0008270|GO:0032298|GO:0034504 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|maintenance of location in cell|cyclin binding|nucleobase-containing compound metabolic process|protein localization|cellular biosynthetic process|regulation of cellular metabolic process|cellular macromolecule biosynthetic process|metal ion binding|maintenance of protein location in cell|DNA metabolic process|cellular protein localization|positive regulation of DNA metabolic process|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|positive regulation of macromolecule biosynthetic process|nucleus|DNA replication initiation|protein localization to organelle|DNA replication|regulation of DNA replication|transition metal ion binding|positive regulation of DNA replication|DNA-dependent DNA replication|positive regulation of DNA-dependent DNA replication|maintenance of protein location in nucleus|regulation of DNA-dependent DNA replication initiation|zinc ion binding|positive regulation of DNA-dependent DNA replication initiation|protein localization to nucleus - - - - 9:128166064-128204383 775 779 880 2051 1986 2000 3.4415884444322 3.14394498044879 3.52333588381729 8.16057107157341 7.2360988202547 8.3236946894677 3.36962310289943 7.90678819376527 -1.23050454544602 2.45680596777164e-09 5.06180023201204e-08 DOWN ENSG00000160191 PDE9A phosphodiesterase 9A [Source:HGNC Symbol;Acc:HGNC:8795] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0044297|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0050817|GO:0006725|GO:0043025|GO:1901360|GO:0034641|GO:0016788|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0003012|GO:0009611|GO:0001726|GO:0043204|GO:0042383|GO:0036477|GO:0006139|GO:0055086|GO:0007154|GO:0007165|GO:0005783|GO:0031256|GO:0031253|GO:0050878|GO:0005794|GO:0005829|GO:0010613|GO:0046872|GO:0019693|GO:0007596|GO:0090257|GO:0042060|GO:0007599|GO:0048471|GO:0032587|GO:0006796|GO:0035556|GO:0010611|GO:0014896|GO:0019439|GO:0046434|GO:0042578|GO:0008081|GO:0009259|GO:0009117|GO:0006163|GO:0009166|GO:0019932|GO:0003300|GO:0006195|GO:0019935|GO:0004112|GO:0009154|GO:0009187|GO:0009214|GO:0046068|GO:0046069|GO:0004114|GO:0019934|GO:0047555 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cell body|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|intracellular|protein binding|plasma membrane|endomembrane system|coagulation|cellular aromatic compound metabolic process|neuronal cell body|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|muscle system process|response to wounding|ruffle|perikaryon|sarcolemma|somatodendritic compartment|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|endoplasmic reticulum|leading edge membrane|cell projection membrane|regulation of body fluid levels|Golgi apparatus|cytosol|positive regulation of cardiac muscle hypertrophy|metal ion binding|ribose phosphate metabolic process|blood coagulation|regulation of muscle system process|wound healing|hemostasis|perinuclear region of cytoplasm|ruffle membrane|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of cardiac muscle hypertrophy|muscle hypertrophy|aromatic compound catabolic process|organophosphate catabolic process|phosphoric ester hydrolase activity|phosphoric diester hydrolase activity|ribonucleotide metabolic process|nucleotide metabolic process|purine nucleotide metabolic process|nucleotide catabolic process|second-messenger-mediated signaling|cardiac muscle hypertrophy|purine nucleotide catabolic process|cyclic-nucleotide-mediated signaling|cyclic-nucleotide phosphodiesterase activity|purine ribonucleotide catabolic process|cyclic nucleotide metabolic process|cyclic nucleotide catabolic process|cGMP metabolic process|cGMP catabolic process|3',5'-cyclic-nucleotide phosphodiesterase activity|cGMP-mediated signaling|3',5'-cyclic-GMP phosphodiesterase activity K13761 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9[3.1.4.35] hsa00230 Purine metabolism - Homo sapiens (human) 21:42653636-42775509 23 23 60 161 151 212 0.252282732087322 0.229281806865633 0.593365850744158 1.58225532943621 1.35893463754947 2.17930546423264 0.358310129899038 1.70683181040611 -2.25204016743748 2.48987710173103e-09 5.1263993789709e-08 DOWN ENSG00000117475 BLZF1 basic leucine zipper nuclear factor 1 [Source:HGNC Symbol;Acc:HGNC:1065] GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0040008|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0007049|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0051128|GO:0043231|GO:0019899|GO:0005737|GO:0045184|GO:0006139|GO:0008104|GO:0061024|GO:0051649|GO:0044249|GO:0001558|GO:0031323|GO:0010256|GO:0005794|GO:0006996|GO:0016192|GO:0003677|GO:0010468|GO:0034645|GO:0090150|GO:0007030|GO:0051252|GO:0015031|GO:0007009|GO:0000278|GO:0046907|GO:0005796|GO:0072657|GO:0031981|GO:0005654|GO:0034613|GO:0010467|GO:0000139|GO:0009059|GO:0016070|GO:0005634|GO:0044389|GO:0031625|GO:0072659|GO:0090002|GO:0032774|GO:2001141|GO:0048193|GO:0006886|GO:1990778|GO:0006351|GO:0006355|GO:0006366|GO:0043001|GO:0006357|GO:1903506|GO:0006892|GO:0006893 growth|cell|membrane|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|regulation of growth|biosynthetic process|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|membrane organization|establishment of localization in cell|cellular biosynthetic process|regulation of cell growth|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|vesicle-mediated transport|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|Golgi organization|regulation of RNA metabolic process|protein transport|plasma membrane organization|mitotic cell cycle|intracellular transport|Golgi lumen|protein localization to membrane|nuclear lumen|nucleoplasm|cellular protein localization|gene expression|Golgi membrane|macromolecule biosynthetic process|RNA metabolic process|nucleus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|protein localization to plasma membrane|establishment of protein localization to plasma membrane|RNA biosynthetic process|regulation of RNA biosynthetic process|Golgi vesicle transport|intracellular protein transport|protein localization to cell periphery|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|Golgi to plasma membrane protein transport|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|post-Golgi vesicle-mediated transport|Golgi to plasma membrane transport - - - - 1:169367970-169396540 192 190 263 615 726 504 2.48927908642534 2.23874402401452 3.07426572779259 7.14404507512031 7.72282097581081 6.12393258039656 2.60076294607748 6.99693287710923 -1.42778774493666 2.49328904179285e-09 5.12988635793824e-08 DOWN ENSG00000103047 TANGO6 transport and golgi organization 6 homolog [Source:HGNC Symbol;Acc:HGNC:25749] GO:0016020|GO:0005488|GO:0031224|GO:0016021 membrane|binding|intrinsic component of membrane|integral component of membrane - - - - 16:68843604-69085180 40 29 52 188 189 126 0.313376347305836 0.206486010073196 0.367304458464433 1.31966060259305 1.21489004144191 0.925136966313934 0.295722271947822 1.15322920344963 -1.96336446864814 2.50121841279132e-09 5.13558284012876e-08 DOWN ENSG00000140688 C16orf58 chromosome 16 open reading frame 58 [Source:HGNC Symbol;Acc:HGNC:25848] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 16:31489471-31509309 296 279 481 886 951 1304 1.79834480347765 1.54051255730639 2.63475697022685 4.82294184173273 4.74055653007443 7.42484510453545 1.99120477700363 5.66278115878087 -1.50786918064208 2.50027940575898e-09 5.13558284012876e-08 DOWN ENSG00000171160 MORN4 MORN repeat containing 4 [Source:HGNC Symbol;Acc:HGNC:24001] GO:0005488|GO:0005515 binding|protein binding - - - - 10:97614553-97633500 84 88 161 435 404 318 2.05743917293679 1.95889286113508 3.55541300285069 9.54630926935542 8.11891649216205 7.29970452445624 2.52391501230752 8.3216434286579 -1.72120514082112 2.49797606978989e-09 5.13558284012876e-08 DOWN ENSG00000213799 ZNF845 zinc finger protein 845 [Source:HGNC Symbol;Acc:HGNC:25112] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:53333749-53354869 1192 1246 967 466 589 496 10.0271514365796 9.52575812690594 7.33402398555228 3.51224300432777 4.06522514265127 3.91032110781566 8.96231118301261 3.82926308493157 1.22680403736697 2.59814626928229e-09 5.33093187100712e-08 UP ENSG00000148296 SURF6 surfeit 6 [Source:HGNC Symbol;Acc:HGNC:11478] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0022613|GO:0005730|GO:0003677|GO:0003723|GO:0042254|GO:0031981|GO:0005654|GO:0005634|GO:0001652|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|ribonucleoprotein complex biogenesis|nucleolus|DNA binding|RNA binding|ribosome biogenesis|nuclear lumen|nucleoplasm|nucleus|granular component|poly(A) RNA binding - - - - 9:133328774-133336398 1796 2004 1324 718 823 576 23.6052352804452 23.9375577693055 15.689323327383 8.45520500457418 8.87502846953749 7.09501755417929 21.0773721257112 8.14175034276365 1.3722841178453 2.60517327345009e-09 5.34167877098757e-08 UP ENSG00000198746 GPATCH3 G-patch domain containing 3 [Source:HGNC Symbol;Acc:HGNC:25720] GO:0005488|GO:0097159|GO:0003676 binding|organic cyclic compound binding|nucleic acid binding - - - - 1:26890488-26900466 576 509 318 148 174 139 14.1473798005768 11.3618983273973 7.04197449587673 3.25696027595532 3.50647308975949 3.19959960955182 10.8504175412836 3.32101099175554 1.70805615799412 2.61338878767477e-09 5.35484618169133e-08 UP ENSG00000129911 KLF16 Kruppel-like factor 16 [Source:HGNC Symbol;Acc:HGNC:16857] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0000981|GO:0009890|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0031324|GO:0031323|GO:0000982|GO:0003677|GO:0007186|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0010467|GO:0001227|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0001078|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0006351|GO:0006355|GO:0007212|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|G-protein coupled receptor signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|dopamine receptor signaling pathway|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 19:1852399-1863568 1301 1304 1452 657 685 677 19.4646022053229 17.7307029631426 19.5861524023886 8.80707310091612 8.4086643606908 9.49261653146093 18.927152523618 8.90278466435595 1.08812881630685 2.65973611977063e-09 5.44539628647202e-08 UP ENSG00000197989 SNHG12 small nucleolar RNA host gene 12 [Source:HGNC Symbol;Acc:HGNC:30062] - - - - - - 1:28578538-28582983 616 573 644 298 293 221 4.74454800364607 4.01095976872438 4.4721251646585 2.05649530648043 1.85161175873799 1.59527255705424 4.40921097900965 1.83445987409089 1.26516516273635 2.66122904199192e-09 5.44539628647202e-08 UP ENSG00000124788 ATXN1 ataxin 1 [Source:HGNC Symbol;Acc:HGNC:10548] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0042802|GO:0042272|GO:0006725|GO:0008022|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0016234|GO:0005737|GO:0009890|GO:0006139|GO:0043621|GO:0051649|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0042405|GO:0010468|GO:0034645|GO:0003723|GO:0010629|GO:0051252|GO:0046907|GO:0031981|GO:0005654|GO:0016363|GO:0010467|GO:0009059|GO:0034399|GO:0016070|GO:0005634|GO:0051169|GO:0006396|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0003727|GO:0006351|GO:0006355|GO:0006913|GO:1903507|GO:1903506|GO:0008187|GO:0051168|GO:0008266|GO:0034046 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|identical protein binding|nuclear RNA export factor complex|cellular aromatic compound metabolic process|protein C-terminus binding|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|inclusion body|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|protein self-association|establishment of localization in cell|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|nuclear inclusion body|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|negative regulation of gene expression|regulation of RNA metabolic process|intracellular transport|nuclear lumen|nucleoplasm|nuclear matrix|gene expression|macromolecule biosynthetic process|nuclear periphery|RNA metabolic process|nucleus|nuclear transport|RNA processing|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|single-stranded RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|poly-pyrimidine tract binding|nuclear export|poly(U) RNA binding|poly(G) binding - - - - 6:16299112-16761491 199 267 456 820 935 1231 0.717133247017137 0.874458203666484 1.48158629979165 2.6476421593499 2.76456747097404 4.15752088689079 1.02439258349176 3.18991017240491 -1.63874708528813 2.67450516886892e-09 5.46881351448032e-08 DOWN ENSG00000187123 LYPD6 LY6/PLAUR domain containing 6 [Source:HGNC Symbol;Acc:HGNC:28751] GO:0005576 extracellular region - - - - 2:149329985-149474148 17 20 39 117 98 134 0.132697384748759 0.141883253319509 0.274477008794412 0.818289046706853 0.627648996536233 0.980293329134921 0.183019215620893 0.808743790792669 -2.14368760228869 2.69544821615159e-09 5.50786523237438e-08 DOWN ENSG00000132661 NXT1 nuclear transport factor 2-like export factor 1 [Source:HGNC Symbol;Acc:HGNC:15913] GO:0005623|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0043231|GO:0019899|GO:0005737|GO:0005635|GO:0045184|GO:0008104|GO:0051649|GO:0006403|GO:0015031|GO:0046907|GO:0031981|GO:0005654|GO:0034613|GO:0050658|GO:0051020|GO:0005634|GO:0005643|GO:0051169|GO:0006611|GO:0016604|GO:0006886|GO:0031267|GO:0006405|GO:0016607|GO:0006913|GO:0017016|GO:0051168|GO:0008536 cell|binding|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|transport|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|nuclear envelope|establishment of protein localization|protein localization|establishment of localization in cell|RNA localization|protein transport|intracellular transport|nuclear lumen|nucleoplasm|cellular protein localization|RNA transport|GTPase binding|nucleus|nuclear pore|nuclear transport|protein export from nucleus|nuclear body|intracellular protein transport|small GTPase binding|RNA export from nucleus|nuclear speck|nucleocytoplasmic transport|Ras GTPase binding|nuclear export|Ran GTPase binding K14285 NTF2-related export protein 1/2[-] hsa05164|hsa03013|hsa03015|hsa03008 Influenza A - Homo sapiens (human)|RNA transport - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human)|Ribosome biogenesis in eukaryotes - Homo sapiens (human) 20:23350736-23354777 1186 1163 893 489 533 355 74.7051781411476 66.5772249260297 50.7144243945735 27.5976660500832 27.5461552913671 20.956724232063 63.9989424872503 25.3668485245044 1.33510377045648 2.72556142019078e-09 5.56558896295318e-08 UP ENSG00000143951 WDPCP WD repeat containing planar cell polarity effector [Source:HGNC Symbol;Acc:HGNC:28027] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0040012|GO:0043229|GO:0045177|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0048646|GO:0008360|GO:0001822|GO:0009888|GO:0048468|GO:0048839|GO:0016324|GO:0005930|GO:0005938|GO:0007275|GO:0048513|GO:0030155|GO:0051128|GO:0022607|GO:0005737|GO:0007423|GO:0032880|GO:0006928|GO:0009887|GO:1901888|GO:0031589|GO:0048598|GO:0048568|GO:0045184|GO:0008104|GO:0007163|GO:0007154|GO:0051270|GO:0060491|GO:0016477|GO:0007165|GO:0030030|GO:0048869|GO:2000145|GO:0032878|GO:0060021|GO:0006996|GO:0000902|GO:0031344|GO:1900027|GO:0090132|GO:0045216|GO:0002093|GO:2000114|GO:0055123|GO:0060113|GO:0042733|GO:0007166|GO:0001654|GO:0007010|GO:0072358|GO:0001655|GO:0043583|GO:0002064|GO:0060541|GO:0000904|GO:0009790|GO:0030334|GO:0001667|GO:0044782|GO:0007160|GO:0072001|GO:0034329|GO:0042472|GO:0030010|GO:0016476|GO:0030031|GO:0010810|GO:0022604|GO:0097541|GO:0070925|GO:0060429|GO:0042384|GO:0035108|GO:0032990|GO:0048562|GO:0007399|GO:0031529|GO:0030154|GO:0048858|GO:0060173|GO:0072359|GO:0005856|GO:0045995|GO:0048666|GO:0030182|GO:0060271|GO:0030855|GO:0043010|GO:0034332|GO:0002066|GO:0007224|GO:0032185|GO:0008544|GO:0042471|GO:0001952|GO:0007044|GO:0010762|GO:0010631|GO:0048041|GO:0042491|GO:0097178|GO:0060119|GO:0022008|GO:0048667|GO:0051893|GO:0030326|GO:0010761|GO:0034333|GO:0048699|GO:0090521|GO:0035315|GO:0060117|GO:0042490|GO:0009913|GO:0060563 locomotion|developmental process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|regulation of locomotion|intracellular organelle|apical part of cell|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of cell shape|kidney development|tissue development|cell development|inner ear development|apical plasma membrane|axoneme|cell cortex|multicellular organism development|animal organ development|regulation of cell adhesion|regulation of cellular component organization|cellular component assembly|cytoplasm|sensory organ development|regulation of protein localization|movement of cell or subcellular component|organ morphogenesis|regulation of cell junction assembly|cell-substrate adhesion|embryonic morphogenesis|embryonic organ development|establishment of protein localization|protein localization|establishment or maintenance of cell polarity|cell communication|regulation of cellular component movement|regulation of cell projection assembly|cell migration|signal transduction|cell projection organization|cellular developmental process|regulation of cell motility|regulation of establishment or maintenance of cell polarity|palate development|organelle organization|cell morphogenesis|regulation of cell projection organization|regulation of ruffle assembly|epithelium migration|cell-cell junction organization|auditory receptor cell morphogenesis|regulation of establishment of cell polarity|digestive system development|inner ear receptor cell differentiation|embryonic digit morphogenesis|cell surface receptor signaling pathway|eye development|cytoskeleton organization|cardiovascular system development|urogenital system development|ear development|epithelial cell development|respiratory system development|cell morphogenesis involved in differentiation|embryo development|regulation of cell migration|ameboidal-type cell migration|cilium organization|cell-matrix adhesion|renal system development|cell junction assembly|inner ear morphogenesis|establishment of cell polarity|regulation of embryonic cell shape|cell projection assembly|regulation of cell-substrate adhesion|regulation of cell morphogenesis|axonemal basal plate|organelle assembly|epithelium development|cilium assembly|limb morphogenesis|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|ruffle organization|cell differentiation|cell projection morphogenesis|limb development|circulatory system development|cytoskeleton|regulation of embryonic development|neuron development|neuron differentiation|cilium morphogenesis|epithelial cell differentiation|camera-type eye development|adherens junction organization|columnar/cuboidal epithelial cell development|smoothened signaling pathway|septin cytoskeleton organization|epidermis development|ear morphogenesis|regulation of cell-matrix adhesion|cell-substrate junction assembly|regulation of fibroblast migration|epithelial cell migration|focal adhesion assembly|auditory receptor cell differentiation|ruffle assembly|inner ear receptor cell development|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of focal adhesion assembly|embryonic limb morphogenesis|fibroblast migration|adherens junction assembly|generation of neurons|glomerular visceral epithelial cell migration|hair cell differentiation|auditory receptor cell development|mechanoreceptor differentiation|epidermal cell differentiation|neuroepithelial cell differentiation - - - - 2:63121383-63827843 17 16 21 79 72 88 0.0755531352471258 0.0646265916854179 0.0841483863881701 0.314584509952867 0.262550303107341 0.366540007586279 0.0747760377735713 0.314558273548829 -2.07267937565995 2.73990978544954e-09 5.59106402835343e-08 DOWN ENSG00000163283 ALPP alkaline phosphatase, placental [Source:HGNC Symbol;Acc:HGNC:439] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043167|GO:0009986|GO:0044237|GO:0071944|GO:0016787|GO:0031224|GO:0005515|GO:0005886|GO:0031225|GO:0016788|GO:0043169|GO:0016021|GO:0046872|GO:0006796|GO:0042578|GO:0016311|GO:0000287|GO:0046914|GO:0016791|GO:0004035|GO:0008270 cell|membrane|cellular process|metabolic process|binding|catalytic activity|ion binding|cell surface|cellular metabolic process|cell periphery|hydrolase activity|intrinsic component of membrane|protein binding|plasma membrane|anchored component of membrane|hydrolase activity, acting on ester bonds|cation binding|integral component of membrane|metal ion binding|phosphate-containing compound metabolic process|phosphoric ester hydrolase activity|dephosphorylation|magnesium ion binding|transition metal ion binding|phosphatase activity|alkaline phosphatase activity|zinc ion binding K01077 alkaline phosphatase[3.1.3.1] hsa01100|hsa00790 Metabolic pathways - Homo sapiens (human)|Folate biosynthesis - Homo sapiens (human) 2:232378534-232382889 440 459 729 1410 1380 2142 6.70780720648025 6.35946165494629 10.0200355735043 19.2594803059635 17.2613516947826 30.6038593398543 7.69576814497695 22.3748971135335 -1.53974380851256 2.8510252932014e-09 5.81383258901876e-08 DOWN ENSG00000123395 ATG101 autophagy related 101 [Source:HGNC Symbol;Acc:HGNC:25679] GO:0005623|GO:0009987|GO:0005488|GO:0044877|GO:0006914|GO:0016043|GO:0005622|GO:0005515|GO:0042802|GO:0022607|GO:0005737|GO:0032403|GO:0016236|GO:0006996|GO:0005829|GO:0070925|GO:0000407|GO:0000045|GO:0007033 cell|cellular process|binding|macromolecular complex binding|autophagy|cellular component organization|intracellular|protein binding|identical protein binding|cellular component assembly|cytoplasm|protein complex binding|macroautophagy|organelle organization|cytosol|organelle assembly|pre-autophagosomal structure|autophagosome assembly|vacuole organization K19730 autophagy-related protein 101[-] hsa04211 Longevity regulating pathway - mammal - Homo sapiens (human) 12:52069246-52077494 1359 1217 1025 500 599 501 18.217052238129 14.8261773553536 12.3878721268924 6.00518027170979 6.58800038184619 6.29397743462393 15.1437005734583 6.29571936272664 1.26627465298502 2.86151865401865e-09 5.83124763802544e-08 UP ENSG00000056050 C4orf27 chromosome 4 open reading frame 27 [Source:HGNC Symbol;Acc:HGNC:26051] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - 4:169729465-169757953 105 128 190 444 463 384 3.52510135015485 3.9054459734793 5.75106603588366 13.3555466465372 12.7535121508156 12.0820595533041 4.39387111983927 12.7303727835523 -1.53471020765379 2.89685602365648e-09 5.89923190520059e-08 DOWN ENSG00000196937 FAM3C family with sequence similarity 3 member C [Source:HGNC Symbol;Acc:HGNC:18664] GO:0032502|GO:0005623|GO:0005576|GO:0005488|GO:1903561|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0007275|GO:0005102|GO:0031982|GO:0043231|GO:0005737|GO:0070062|GO:0005794|GO:0031410|GO:0005125|GO:0016023|GO:0031988 developmental process|cell|extracellular region|binding|extracellular vesicle|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|anatomical structure development|multicellular organism development|receptor binding|vesicle|intracellular membrane-bounded organelle|cytoplasm|extracellular exosome|Golgi apparatus|cytoplasmic vesicle|cytokine activity|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle - - - - 7:121348851-121396364 428 498 698 1304 1577 1309 7.35195639187506 7.77443838870625 10.8100887740875 20.0694207664387 22.2258832887929 21.0730866429687 8.64549451822294 21.1227968994001 -1.28878048381608 2.90056213581475e-09 5.90275269274803e-08 DOWN ENSG00000279541 CTC-444N24.7 - - - - - - - 19:57293083-57294469 2 0 4 23 22 36 0.101995043905069 0 0.183930935823255 1.05099318734764 0.92059691039319 1.72066971924979 0.0953086599094413 1.23075327233021 -3.69079045934025 2.91579789226526e-09 5.92971595883426e-08 DOWN ENSG00000061987 MON2 MON2 homolog, regulator of endosome-to-Golgi trafficking [Source:HGNC Symbol;Acc:HGNC:29177] GO:0005623|GO:0005576|GO:0005488|GO:1903561|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0006810|GO:0031982|GO:0005737|GO:0045184|GO:0008104|GO:0070062|GO:0051649|GO:0016192|GO:0015031|GO:0046907|GO:0048193|GO:0016482|GO:0016197|GO:0006892|GO:0006895 cell|extracellular region|binding|extracellular vesicle|cellular localization|membrane-bounded organelle|intracellular|protein binding|transport|vesicle|cytoplasm|establishment of protein localization|protein localization|extracellular exosome|establishment of localization in cell|vesicle-mediated transport|protein transport|intracellular transport|Golgi vesicle transport|cytosolic transport|endosomal transport|post-Golgi vesicle-mediated transport|Golgi to endosome transport - - - - 12:62466817-62600479 179 213 314 600 683 701 0.576325488656676 0.623269265703217 0.91150543195895 1.73087069639781 1.80428296602305 2.11525536641164 0.703700062106281 1.8834696762775 -1.42036026073289 2.9272910169379e-09 5.94498952514722e-08 DOWN ENSG00000167371 PRRT2 proline-rich transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:30500] GO:0045202|GO:0005623|GO:0016020|GO:0030054|GO:0050896|GO:0071944|GO:0009607|GO:0031224|GO:0005886|GO:0050877|GO:0016021|GO:0050905|GO:0050884 synapse|cell|membrane|cell junction|response to stimulus|cell periphery|response to biotic stimulus|intrinsic component of membrane|plasma membrane|neurological system process|integral component of membrane|neuromuscular process|neuromuscular process controlling posture - - - - 16:29811382-29815892 2 1 6 25 28 39 0.0155766489645816 0.00708189019345291 0.0421348064281305 0.174464793664925 0.178933375487191 0.284683621832527 0.021597781862055 0.212693930328214 -3.29982380625455 2.92614869474119e-09 5.94498952514722e-08 DOWN ENSG00000178150 ZNF114 zinc finger protein 114 [Source:HGNC Symbol;Acc:HGNC:12894] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0070062|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|extracellular exosome|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 19:48172318-48287608 449 372 233 104 79 113 3.51414700543 2.64604306513937 1.64416010171373 0.729300322690272 0.507304586556773 0.828856599406657 2.6014500574277 0.688487169551234 1.91781433668384 2.94033915567714e-09 5.96742931023693e-08 UP ENSG00000005108 THSD7A thrombospondin type 1 domain containing 7A [Source:HGNC Symbol;Acc:HGNC:22207] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:1903561|GO:0009653|GO:0043227|GO:0071944|GO:0031224|GO:0005886|GO:0048856|GO:0048646|GO:0048514|GO:0001568|GO:0007275|GO:0031982|GO:0001525|GO:0070062|GO:0048869|GO:0016021|GO:0001944|GO:0072358|GO:0030154|GO:0072359 developmental process|cell|membrane|cellular process|extracellular region|extracellular vesicle|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|intrinsic component of membrane|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|blood vessel development|multicellular organism development|vesicle|angiogenesis|extracellular exosome|cellular developmental process|integral component of membrane|vasculature development|cardiovascular system development|cell differentiation|circulatory system development - - - - 7:11370357-11832198 4 6 3 36 32 86 0.0154456955886374 0.0210570920665147 0.0104433225140993 0.124557625048259 0.101387137450279 0.311239178403088 0.0156487033897505 0.179061313633875 -3.51633864604209 2.9458791128073e-09 5.97055499210788e-08 DOWN ENSG00000106692 FKTN fukutin [Source:HGNC Symbol;Acc:HGNC:3622] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0023057|GO:0009058|GO:0031224|GO:0005615|GO:0005622|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0006486|GO:0044262|GO:0042127|GO:0007275|GO:0048513|GO:0033554|GO:0061061|GO:0043231|GO:0005737|GO:0005975|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0005783|GO:0009968|GO:0008285|GO:0016021|GO:0044249|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0005794|GO:0000165|GO:0032268|GO:0006109|GO:0034645|GO:0043412|GO:0005801|GO:0006493|GO:0009100|GO:0036211|GO:0032269|GO:0031098|GO:0070085|GO:0035268|GO:0006796|GO:0035556|GO:1901137|GO:0044267|GO:0051174|GO:0007399|GO:0000139|GO:1902532|GO:0051246|GO:0009059|GO:0007517|GO:1902531|GO:0005634|GO:0060049|GO:0097502|GO:0009101|GO:0043413|GO:0043408|GO:0016310|GO:0032872|GO:0010559|GO:0043409|GO:0006464|GO:0051403|GO:0035269|GO:0046328|GO:0006468|GO:0042325|GO:0007254|GO:0001932|GO:0042326|GO:0001933|GO:0032873|GO:0046329 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intrinsic component of membrane|extracellular space|intracellular|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|protein glycosylation|cellular carbohydrate metabolic process|regulation of cell proliferation|multicellular organism development|animal organ development|cellular response to stress|muscle structure development|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|negative regulation of cell proliferation|integral component of membrane|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|MAPK cascade|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|cis-Golgi network|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|negative regulation of cellular protein metabolic process|stress-activated protein kinase signaling cascade|glycosylation|protein mannosylation|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|Golgi membrane|negative regulation of intracellular signal transduction|regulation of protein metabolic process|macromolecule biosynthetic process|muscle organ development|regulation of intracellular signal transduction|nucleus|regulation of protein glycosylation|mannosylation|glycoprotein biosynthetic process|macromolecule glycosylation|regulation of MAPK cascade|phosphorylation|regulation of stress-activated MAPK cascade|regulation of glycoprotein biosynthetic process|negative regulation of MAPK cascade|cellular protein modification process|stress-activated MAPK cascade|protein O-linked mannosylation|regulation of JNK cascade|protein phosphorylation|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|negative regulation of stress-activated MAPK cascade|negative regulation of JNK cascade - - - - 9:105558130-105641118 209 223 342 767 694 679 0.865929268208863 0.839694183113124 1.27754699209548 2.8472722389173 2.35919297488488 2.63654088042539 0.994390147805822 2.61433536474252 -1.39456031303588 2.94387979703525e-09 5.97055499210788e-08 DOWN ENSG00000163902 RPN1 ribophorin I [Source:HGNC Symbol;Acc:HGNC:10381] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0006810|GO:0003676|GO:0034641|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0045184|GO:0008104|GO:0061024|GO:0005783|GO:0016757|GO:0051649|GO:0008250|GO:0016021|GO:0044249|GO:0019538|GO:0034645|GO:0090150|GO:0006518|GO:0003723|GO:0043412|GO:0072594|GO:0006487|GO:0031410|GO:0045047|GO:0015031|GO:0016023|GO:0009100|GO:0036211|GO:0046907|GO:0005791|GO:0016758|GO:0072657|GO:1990234|GO:0031988|GO:0070085|GO:0034613|GO:0043603|GO:1901137|GO:0044267|GO:0010467|GO:0009059|GO:0009101|GO:0043043|GO:0043413|GO:0006614|GO:0033365|GO:0004576|GO:0018279|GO:0006605|GO:0006412|GO:0006886|GO:0044822|GO:0006464|GO:0006612|GO:0072599|GO:0070972|GO:0006613|GO:0004579|GO:0042470|GO:0018193|GO:0043687 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|transferase activity|organelle membrane|protein glycosylation|transport|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|establishment of protein localization|protein localization|membrane organization|endoplasmic reticulum|transferase activity, transferring glycosyl groups|establishment of localization in cell|oligosaccharyltransferase complex|integral component of membrane|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|peptide metabolic process|RNA binding|macromolecule modification|establishment of protein localization to organelle|protein N-linked glycosylation|cytoplasmic vesicle|protein targeting to ER|protein transport|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|protein modification process|intracellular transport|rough endoplasmic reticulum|transferase activity, transferring hexosyl groups|protein localization to membrane|transferase complex|membrane-bounded vesicle|glycosylation|cellular protein localization|cellular amide metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|glycoprotein biosynthetic process|peptide biosynthetic process|macromolecule glycosylation|SRP-dependent cotranslational protein targeting to membrane|protein localization to organelle|oligosaccharyl transferase activity|protein N-linked glycosylation via asparagine|protein targeting|translation|intracellular protein transport|poly(A) RNA binding|cellular protein modification process|protein targeting to membrane|establishment of protein localization to endoplasmic reticulum|protein localization to endoplasmic reticulum|cotranslational protein targeting to membrane|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|melanosome|peptidyl-amino acid modification|post-translational protein modification K12666 oligosaccharyltransferase complex subunit alpha (ribophorin I)[-] hsa01100|hsa04141|hsa00510 Metabolic pathways - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 3:128619970-128681075 2433 2635 2859 6778 7328 5665 28.2598921341917 27.8156410428495 29.9403522002735 70.538740271462 69.8363987316101 61.6676392891284 28.6719617924382 67.3475927640668 -1.23198575968887 3.01021005139025e-09 6.09679856677099e-08 DOWN ENSG00000187957 DNER delta/notch like EGF repeat containing [Source:HGNC Symbol;Acc:HGNC:24456] GO:0040011|GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0048870|GO:0044297|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0009888|GO:0048468|GO:0043025|GO:0006810|GO:0007275|GO:0048513|GO:0005102|GO:0030276|GO:0022607|GO:0061061|GO:0043231|GO:0043169|GO:0004888|GO:0005737|GO:0006928|GO:0043005|GO:0036477|GO:0007154|GO:0016477|GO:0007165|GO:0050808|GO:0048869|GO:0016021|GO:0019538|GO:0005768|GO:0005112|GO:0016192|GO:0007416|GO:0046872|GO:0007166|GO:0007417|GO:0005769|GO:0042692|GO:0060537|GO:0001764|GO:0030425|GO:0055001|GO:0044267|GO:0007399|GO:0030154|GO:0007517|GO:0055002|GO:0060538|GO:0010001|GO:0007220|GO:0005509|GO:0051146|GO:0006897|GO:0007219|GO:0014706|GO:0022008|GO:0048699|GO:0007519|GO:0048747|GO:0014902|GO:0042063|GO:0014904|GO:0048741 locomotion|developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|cell motility|cell body|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|tissue development|cell development|neuronal cell body|transport|multicellular organism development|animal organ development|receptor binding|clathrin binding|cellular component assembly|muscle structure development|intracellular membrane-bounded organelle|cation binding|transmembrane signaling receptor activity|cytoplasm|movement of cell or subcellular component|neuron projection|somatodendritic compartment|cell communication|cell migration|signal transduction|synapse organization|cellular developmental process|integral component of membrane|protein metabolic process|endosome|Notch binding|vesicle-mediated transport|synapse assembly|metal ion binding|cell surface receptor signaling pathway|central nervous system development|early endosome|muscle cell differentiation|muscle tissue development|neuron migration|dendrite|muscle cell development|cellular protein metabolic process|nervous system development|cell differentiation|muscle organ development|striated muscle cell development|skeletal muscle organ development|glial cell differentiation|Notch receptor processing|calcium ion binding|striated muscle cell differentiation|endocytosis|Notch signaling pathway|striated muscle tissue development|neurogenesis|generation of neurons|skeletal muscle tissue development|muscle fiber development|myotube differentiation|gliogenesis|myotube cell development|skeletal muscle fiber development - - - - 2:229357629-229714558 16 42 31 143 174 107 0.287624718708904 0.686166883690195 0.502436146816074 2.30322068381783 2.56636404028141 1.80266619394436 0.492075916405058 2.22408363934787 -2.17625822965889 3.0993198360397e-09 6.27302334814436e-08 DOWN ENSG00000166435 XRRA1 X-ray radiation resistance associated 1 [Source:HGNC Symbol;Acc:HGNC:18868] GO:0005623|GO:0050896|GO:0005488|GO:0043229|GO:0009628|GO:0043227|GO:0005622|GO:0005515|GO:0009314|GO:0043231|GO:0005737|GO:0010212|GO:0005634|GO:0010165 cell|response to stimulus|binding|intracellular organelle|response to abiotic stimulus|membrane-bounded organelle|intracellular|protein binding|response to radiation|intracellular membrane-bounded organelle|cytoplasm|response to ionizing radiation|nucleus|response to X-ray - - - - 11:74807739-74949200 79 90 73 286 287 237 0.279576915460585 0.28946653927938 0.232924638444541 0.906858248120586 0.833346971655065 0.786056440040546 0.267322697728169 0.842087219938732 -1.65538733091069 3.11805563872299e-09 6.3066689050431e-08 DOWN ENSG00000172534 HCFC1 host cell factor C1 [Source:HGNC Symbol;Acc:HGNC:4839] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0042995|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0044297|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0042802|GO:0016032|GO:0051726|GO:0007049|GO:0003712|GO:0006725|GO:0043025|GO:1901360|GO:0016570|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0043231|GO:0016746|GO:0005737|GO:0000981|GO:0043005|GO:0009890|GO:0036477|GO:0045787|GO:0003682|GO:0006139|GO:0031647|GO:0044249|GO:0019538|GO:0043254|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0003713|GO:0051276|GO:0010468|GO:0034645|GO:0030424|GO:0043412|GO:0010629|GO:0050821|GO:0007005|GO:0051252|GO:0006325|GO:0016573|GO:0010628|GO:0036211|GO:0003705|GO:0031981|GO:0019046|GO:1990234|GO:0030425|GO:0005654|GO:0005739|GO:0016747|GO:0006461|GO:0014070|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0000123|GO:0009059|GO:0001228|GO:0035097|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0048188|GO:0045892|GO:0001205|GO:0032774|GO:2001141|GO:0043967|GO:1902679|GO:0071407|GO:0070688|GO:0016407|GO:0016410|GO:0005671|GO:0016568|GO:0070461|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0018193|GO:0043984|GO:0008080|GO:0000122|GO:0043981|GO:0043982|GO:0071339|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402|GO:0010485|GO:0043995|GO:0043996|GO:0046972 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cell body|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|identical protein binding|viral process|regulation of cell cycle|cell cycle|transcription cofactor activity|cellular aromatic compound metabolic process|neuronal cell body|organic cyclic compound metabolic process|histone modification|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|neuron projection|negative regulation of biosynthetic process|somatodendritic compartment|positive regulation of cell cycle|chromatin binding|nucleobase-containing compound metabolic process|regulation of protein stability|cellular biosynthetic process|protein metabolic process|regulation of protein complex assembly|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|axon|macromolecule modification|negative regulation of gene expression|protein stabilization|mitochondrion organization|regulation of RNA metabolic process|chromatin organization|histone acetylation|positive regulation of gene expression|protein modification process|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nuclear lumen|release from viral latency|transferase complex|dendrite|nucleoplasm|mitochondrion|transferase activity, transferring acyl groups other than amino-acyl groups|protein complex assembly|response to organic cyclic compound|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|histone acetyltransferase complex|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|histone methyltransferase complex|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|Set1C/COMPASS complex|negative regulation of transcription, DNA-templated|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding|RNA biosynthetic process|regulation of RNA biosynthetic process|histone H4 acetylation|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|MLL5-L complex|acetyltransferase activity|N-acyltransferase activity|Ada2/Gcn5/Ada3 transcription activator complex|chromatin modification|SAGA-type complex|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone H4-K16 acetylation|N-acetyltransferase activity|negative regulation of transcription from RNA polymerase II promoter|histone H4-K5 acetylation|histone H4-K8 acetylation|MLL1 complex|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity|H4 histone acetyltransferase activity|histone acetyltransferase activity (H4-K5 specific)|histone acetyltransferase activity (H4-K8 specific)|histone acetyltransferase activity (H4-K16 specific) K14966 host cell factor[-] hsa05168 Herpes simplex infection - Homo sapiens (human) X:153947553-153971807 5148 5689 3987 2094 2442 2082 25.6139371780313 25.7249010267774 17.8853850037317 9.33495231651324 9.96899486393486 9.70839621558753 23.0747410695135 9.67078113201188 1.25461012949579 3.14527806138535e-09 6.35742256226121e-08 UP ENSG00000026751 SLAMF7 SLAM family member 7 [Source:HGNC Symbol;Acc:HGNC:21394] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0045321|GO:0001909|GO:0043229|GO:0006950|GO:0006955|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0042267|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0045087|GO:0006952|GO:0043231|GO:0005737|GO:0001775|GO:0050776|GO:0046649|GO:0005783|GO:0016021|GO:0002443|GO:0030101|GO:0002228 immune system process|cell|membrane|cellular process|response to stimulus|binding|leukocyte activation|leukocyte mediated cytotoxicity|intracellular organelle|response to stress|immune response|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|natural killer cell mediated cytotoxicity|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|innate immune response|defense response|intracellular membrane-bounded organelle|cytoplasm|cell activation|regulation of immune response|lymphocyte activation|endoplasmic reticulum|integral component of membrane|leukocyte mediated immunity|natural killer cell activation|natural killer cell mediated immunity - - - - 1:160739057-160754821 43 50 39 6 11 10 0.398703481340063 0.421335050983546 0.326033641852793 0.0498473083813092 0.0836813339472029 0.0868957885080066 0.382024058058801 0.0734748102788396 2.37834186142133 3.16526761765742e-09 6.39349793352806e-08 UP ENSG00000183255 PTTG1IP pituitary tumor-transforming 1 interacting protein [Source:HGNC Symbol;Acc:HGNC:13524] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0009893|GO:0031224|GO:0005622|GO:0005515|GO:0019222|GO:0006810|GO:0010941|GO:0002039|GO:0031982|GO:0031325|GO:0033554|GO:0043231|GO:0005737|GO:0009966|GO:0045184|GO:0060548|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0051649|GO:0008219|GO:0016021|GO:0019538|GO:0031323|GO:0043518|GO:0032268|GO:0045732|GO:0043412|GO:0072594|GO:0030163|GO:0043069|GO:2001234|GO:0015031|GO:0044265|GO:0036211|GO:0046907|GO:2001020|GO:0051247|GO:0034613|GO:0032270|GO:0012501|GO:0035556|GO:0044267|GO:0042176|GO:0017038|GO:1902532|GO:0051246|GO:1902531|GO:0005634|GO:0043067|GO:0006974|GO:0006606|GO:0097190|GO:0044257|GO:0097193|GO:2001242|GO:0033365|GO:0031401|GO:1901797|GO:0051169|GO:0072331|GO:0042770|GO:1903364|GO:2001243|GO:0006605|GO:0006886|GO:1901796|GO:0042981|GO:0043066|GO:0006464|GO:0006915|GO:0043516|GO:0006913|GO:0072332|GO:1902254|GO:1902253|GO:0030330|GO:0034504|GO:0032446|GO:0051170|GO:0031398|GO:0031396|GO:0016567 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|intracellular|protein binding|regulation of metabolic process|transport|regulation of cell death|p53 binding|vesicle|positive regulation of cellular metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|establishment of protein localization|negative regulation of cell death|regulation of cell communication|protein localization|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|cell death|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|negative regulation of DNA damage response, signal transduction by p53 class mediator|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|macromolecule modification|establishment of protein localization to organelle|protein catabolic process|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|protein transport|cellular macromolecule catabolic process|protein modification process|intracellular transport|regulation of response to DNA damage stimulus|positive regulation of protein metabolic process|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|intracellular signal transduction|cellular protein metabolic process|regulation of protein catabolic process|protein import|negative regulation of intracellular signal transduction|regulation of protein metabolic process|regulation of intracellular signal transduction|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|protein import into nucleus|apoptotic signaling pathway|cellular protein catabolic process|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|protein localization to organelle|positive regulation of protein modification process|negative regulation of signal transduction by p53 class mediator|nuclear transport|signal transduction by p53 class mediator|signal transduction in response to DNA damage|positive regulation of cellular protein catabolic process|negative regulation of intrinsic apoptotic signaling pathway|protein targeting|intracellular protein transport|regulation of signal transduction by p53 class mediator|regulation of apoptotic process|negative regulation of apoptotic process|cellular protein modification process|apoptotic process|regulation of DNA damage response, signal transduction by p53 class mediator|nucleocytoplasmic transport|intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|DNA damage response, signal transduction by p53 class mediator|protein localization to nucleus|protein modification by small protein conjugation|nuclear import|positive regulation of protein ubiquitination|regulation of protein ubiquitination|protein ubiquitination - - - - 21:44849585-44873903 1489 1706 2618 4898 5289 4875 15.6341317217696 16.2793912788369 24.7835240439963 46.0782195041878 45.5638851147502 47.9714347406645 18.8990156815343 46.5378464532008 -1.30009335488984 3.21797223131566e-09 6.49556071627436e-08 DOWN ENSG00000150990 DHX37 DEAH (Asp-Glu-Ala-His) box polypeptide 37 [Source:HGNC Symbol;Acc:HGNC:17210] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0016817|GO:0043231|GO:0006139|GO:0000166|GO:0005730|GO:0003723|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0031981|GO:0010467|GO:0017076|GO:0016070|GO:0005634|GO:0006396|GO:0005524|GO:0030554|GO:0044822|GO:0016462|GO:0017111|GO:0016887|GO:0004386|GO:0042623|GO:0003724|GO:0008026|GO:0004004|GO:0008186 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleotide binding|nucleolus|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|gene expression|purine nucleotide binding|RNA metabolic process|nucleus|RNA processing|ATP binding|adenyl nucleotide binding|poly(A) RNA binding|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|helicase activity|ATPase activity, coupled|RNA helicase activity|ATP-dependent helicase activity|ATP-dependent RNA helicase activity|RNA-dependent ATPase activity - - - - 12:124946825-124989122 896 995 731 369 453 299 6.10657942800919 6.16301732755061 4.49181242557601 2.25327422047128 2.53312539094996 1.90980884037015 5.58713639371194 2.23206948393046 1.32372710122314 3.24035453026095e-09 6.53632055043314e-08 UP ENSG00000183305 MAGEA2B MAGE family member A2B [Source:HGNC Symbol;Acc:HGNC:19340] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0009890|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0008134|GO:0050790|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0007568|GO:0032268|GO:0010468|GO:0034645|GO:0043412|GO:0030163|GO:0010629|GO:0051252|GO:0070491|GO:0044265|GO:0051347|GO:0036211|GO:0032269|GO:0007569|GO:0031981|GO:0051351|GO:0042826|GO:0051247|GO:0005654|GO:0032270|GO:0035556|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0090398|GO:0044389|GO:0031625|GO:0044257|GO:0031401|GO:0045892|GO:0072331|GO:0032774|GO:2001141|GO:1902679|GO:0016604|GO:0051438|GO:0051443|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:1901984|GO:0018193|GO:0016605|GO:0000122|GO:0032446|GO:0031398|GO:0033234|GO:0031396|GO:0033233|GO:0006473|GO:0018205|GO:0016925|GO:0016567 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|transcription factor binding|regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|aging|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|protein catabolic process|negative regulation of gene expression|regulation of RNA metabolic process|repressing transcription factor binding|cellular macromolecule catabolic process|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|cell aging|nuclear lumen|positive regulation of ligase activity|histone deacetylase binding|positive regulation of protein metabolic process|nucleoplasm|positive regulation of cellular protein metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular senescence|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|positive regulation of protein modification process|negative regulation of transcription, DNA-templated|signal transduction by p53 class mediator|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|nuclear body|regulation of ubiquitin-protein transferase activity|positive regulation of ubiquitin-protein transferase activity|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of protein acetylation|peptidyl-amino acid modification|PML body|negative regulation of transcription from RNA polymerase II promoter|protein modification by small protein conjugation|positive regulation of protein ubiquitination|negative regulation of protein sumoylation|regulation of protein ubiquitination|regulation of protein sumoylation|protein acetylation|peptidyl-lysine modification|protein sumoylation|protein ubiquitination - - - - X:152714586-152718607 364 313 260 106 131 92 3.3830258323758 2.64379923471378 2.17867468519552 0.882684785636092 0.998952571016937 0.801348608462027 2.73516658409503 0.894328655038352 1.61275169532901 3.26468850216213e-09 6.58095952353465e-08 UP ENSG00000166147 FBN1 fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] GO:0032502|GO:0031012|GO:0005198|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0005604|GO:1903561|GO:0051716|GO:0043205|GO:0005201|GO:0048523|GO:0044877|GO:0050794|GO:0005578|GO:0006807|GO:0097493|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009058|GO:0005615|GO:0005515|GO:0048856|GO:0019222|GO:0007507|GO:0009791|GO:0048569|GO:0006725|GO:0001822|GO:1901360|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0043062|GO:0031982|GO:0046483|GO:0090287|GO:0043169|GO:0010243|GO:0007423|GO:0071559|GO:0009887|GO:0032403|GO:0009966|GO:0048598|GO:0048568|GO:0050839|GO:0001527|GO:0010646|GO:0090288|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0009725|GO:0030023|GO:0044249|GO:0010033|GO:0031323|GO:0010468|GO:0071773|GO:0034645|GO:0046872|GO:0090101|GO:0007166|GO:0001654|GO:0022617|GO:0030514|GO:0072358|GO:0001655|GO:0051252|GO:1901652|GO:0009790|GO:1900116|GO:0071417|GO:0001656|GO:0071560|GO:0005178|GO:0072001|GO:0048563|GO:0043434|GO:0070848|GO:0010467|GO:0048562|GO:0071310|GO:0030198|GO:0030510|GO:0009059|GO:0001501|GO:0016070|GO:0072359|GO:0032870|GO:0048050|GO:0035583|GO:1901653|GO:0043010|GO:0032774|GO:2001141|GO:0071363|GO:0005509|GO:0007179|GO:0048048|GO:0030512|GO:0030509|GO:0007167|GO:0071375|GO:0035582|GO:0035581|GO:0017015|GO:0006351|GO:0006355|GO:0048592|GO:0006366|GO:1990314|GO:0006357|GO:1903506|GO:0007178 developmental process|extracellular matrix|structural molecule activity|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|basement membrane|extracellular vesicle|cellular response to stimulus|fibril|extracellular matrix structural constituent|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|proteinaceous extracellular matrix|nitrogen compound metabolic process|structural molecule activity conferring elasticity|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|extracellular space|protein binding|anatomical structure development|regulation of metabolic process|heart development|post-embryonic development|post-embryonic organ development|cellular aromatic compound metabolic process|kidney development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|extracellular structure organization|vesicle|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|cation binding|response to organonitrogen compound|sensory organ development|response to transforming growth factor beta|organ morphogenesis|protein complex binding|regulation of signal transduction|embryonic morphogenesis|embryonic organ development|cell adhesion molecule binding|microfibril|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|response to hormone|extracellular matrix constituent conferring elasticity|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|eye development|extracellular matrix disassembly|negative regulation of BMP signaling pathway|cardiovascular system development|urogenital system development|regulation of RNA metabolic process|response to peptide|embryo development|extracellular negative regulation of signal transduction|cellular response to organonitrogen compound|metanephros development|cellular response to transforming growth factor beta stimulus|integrin binding|renal system development|post-embryonic organ morphogenesis|response to peptide hormone|response to growth factor|gene expression|embryonic organ morphogenesis|cellular response to organic substance|extracellular matrix organization|regulation of BMP signaling pathway|macromolecule biosynthetic process|skeletal system development|RNA metabolic process|circulatory system development|cellular response to hormone stimulus|post-embryonic eye morphogenesis|sequestering of TGFbeta in extracellular matrix|cellular response to peptide|camera-type eye development|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|calcium ion binding|transforming growth factor beta receptor signaling pathway|embryonic eye morphogenesis|negative regulation of transforming growth factor beta receptor signaling pathway|BMP signaling pathway|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|sequestering of BMP in extracellular matrix|sequestering of extracellular ligand from receptor|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|transcription from RNA polymerase II promoter|cellular response to insulin-like growth factor stimulus|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway - - - - 15:48408306-48645849 4 5 2 32 31 82 0.0147507560498754 0.0167596546088951 0.00665012793876373 0.105736049486818 0.0938013908335746 0.283412558702722 0.0127201795325114 0.160983333007705 -3.66172039231346 3.26700515064139e-09 6.58118567930149e-08 DOWN ENSG00000160305 DIP2A disco interacting protein 2 homolog A [Source:HGNC Symbol;Acc:HGNC:17217] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0050794|GO:0043229|GO:0071704|GO:0009986|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0010941|GO:0007275|GO:0043231|GO:0008134|GO:0008219|GO:0010468|GO:0010629|GO:0012501|GO:0010467|GO:0005634|GO:0043067|GO:0042981|GO:0006915 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cell surface|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell death|multicellular organism development|intracellular membrane-bounded organelle|transcription factor binding|cell death|regulation of gene expression|negative regulation of gene expression|programmed cell death|gene expression|nucleus|regulation of programmed cell death|regulation of apoptotic process|apoptotic process - - - - 21:46458899-46569852 282 370 516 949 1005 1265 1.05099011615738 1.2532330146771 1.73385706542179 3.16893621708149 3.07314948251771 4.41843914112873 1.34602673208542 3.55350828024264 -1.40053699886302 3.29424465781296e-09 6.63158327810844e-08 DOWN ENSG00000039123 SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:18734] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:0000178|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0016817|GO:0043231|GO:0030529|GO:0006139|GO:0000166|GO:0022613|GO:0005730|GO:0003723|GO:0035639|GO:0001883|GO:0044265|GO:0042254|GO:0016818|GO:0032549|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0017076|GO:0019439|GO:0016070|GO:0005634|GO:0006401|GO:0006364|GO:0006396|GO:0005524|GO:0034660|GO:0030554|GO:0016071|GO:0044822|GO:0016462|GO:0071013|GO:0000460|GO:0017111|GO:0006397|GO:0016072|GO:0008380|GO:0000375|GO:0004386|GO:0000398|GO:0003724 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|exosome (RNase complex)|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|nucleotide binding|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|cellular macromolecule catabolic process|ribosome biogenesis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|purine nucleotide binding|aromatic compound catabolic process|RNA metabolic process|nucleus|RNA catabolic process|rRNA processing|RNA processing|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|mRNA metabolic process|poly(A) RNA binding|pyrophosphatase activity|catalytic step 2 spliceosome|maturation of 5.8S rRNA|nucleoside-triphosphatase activity|mRNA processing|rRNA metabolic process|RNA splicing|RNA splicing, via transesterification reactions|helicase activity|mRNA splicing, via spliceosome|RNA helicase activity K12598 ATP-dependent RNA helicase DOB1[3.6.4.13] hsa03018 RNA degradation - Homo sapiens (human) 5:55307760-55425581 573 720 863 1896 2054 1552 4.83331981950181 5.51954666661648 6.56320340848538 14.3293652629621 14.2154035229078 12.2690652744505 5.63868996486789 13.6046113534401 -1.27066381755745 3.35501004520808e-09 6.74935780927507e-08 DOWN ENSG00000126217 MCF2L MCF.2 cell line derived transforming sequence like [Source:HGNC Symbol;Acc:HGNC:14576] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0071944|GO:0009893|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0005085|GO:0019222|GO:0010941|GO:0010942|GO:0005737|GO:0005088|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0010033|GO:0005829|GO:0007166|GO:0051345|GO:0070848|GO:0012501|GO:0035556|GO:0071310|GO:0005089|GO:0043068|GO:1902531|GO:0043067|GO:0097190|GO:0043065|GO:0071363|GO:0043087|GO:0038179|GO:0043547|GO:0007167|GO:0042981|GO:0051056|GO:0007264|GO:0006915|GO:0048011|GO:0007265|GO:0046578|GO:0007169|GO:0035023|GO:0007266 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|cell periphery|positive regulation of metabolic process|extracellular space|intracellular|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|regulation of metabolic process|regulation of cell death|positive regulation of cell death|cytoplasm|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|response to organic substance|cytosol|cell surface receptor signaling pathway|positive regulation of hydrolase activity|response to growth factor|programmed cell death|intracellular signal transduction|cellular response to organic substance|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|regulation of programmed cell death|apoptotic signaling pathway|positive regulation of apoptotic process|cellular response to growth factor stimulus|regulation of GTPase activity|neurotrophin signaling pathway|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of apoptotic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|apoptotic process|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction - - - - 13:112894378-113099739 180 195 238 478 606 791 0.324448009357094 0.319438750638987 0.386779530249093 0.771965692963874 0.89621716043334 1.33621910741928 0.343555430081725 1.00146732027216 -1.54350055319836 3.36071861928484e-09 6.75628913536226e-08 DOWN ENSG00000181026 AEN apoptosis enhancing nuclease [Source:HGNC Symbol;Acc:HGNC:25722] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0006725|GO:0009314|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0033554|GO:0043231|GO:0005635|GO:0006139|GO:0007154|GO:0007165|GO:0008219|GO:0031965|GO:0005730|GO:0031981|GO:0004518|GO:0005654|GO:0012501|GO:0010212|GO:0035556|GO:0005634|GO:0006974|GO:0097190|GO:0097193|GO:0072331|GO:0004527|GO:0008630|GO:0090305|GO:0006915|GO:0072332|GO:0042771 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|nuclear envelope|nucleobase-containing compound metabolic process|cell communication|signal transduction|cell death|nuclear membrane|nucleolus|nuclear lumen|nuclease activity|nucleoplasm|programmed cell death|response to ionizing radiation|intracellular signal transduction|nucleus|cellular response to DNA damage stimulus|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|signal transduction by p53 class mediator|exonuclease activity|intrinsic apoptotic signaling pathway in response to DNA damage|nucleic acid phosphodiester bond hydrolysis|apoptotic process|intrinsic apoptotic signaling pathway by p53 class mediator|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator - - - - 15:88621296-88632282 902 1047 725 374 441 261 5.48291273712686 5.78404198253496 3.97335392295496 2.03692269970024 2.19943630733025 1.48687510207501 5.08010288087226 1.90774470303517 1.41298959349644 3.49491347121735e-09 7.02134231290194e-08 UP ENSG00000144231 POLR2D polymerase (RNA) II (DNA directed) polypeptide D [Source:HGNC Symbol;Acc:HGNC:9191] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0016032|GO:0006281|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0071166|GO:0034641|GO:0016772|GO:0048524|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0009408|GO:0016458|GO:0006139|GO:0031990|GO:0051649|GO:0006403|GO:0000166|GO:0044249|GO:0009266|GO:0022613|GO:0019827|GO:0019538|GO:0050792|GO:0031323|GO:0031369|GO:0035770|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0031047|GO:0010629|GO:0051252|GO:0006446|GO:0044265|GO:0010628|GO:0046907|GO:0019083|GO:0022618|GO:0031981|GO:1990234|GO:0034605|GO:0051247|GO:0005654|GO:0006259|GO:0035019|GO:0032270|GO:0050658|GO:0043603|GO:0044267|GO:1903902|GO:0045948|GO:0010467|GO:0019058|GO:0031328|GO:0019439|GO:0051246|GO:0009059|GO:0016779|GO:0006289|GO:0016070|GO:0010557|GO:0005634|GO:0036464|GO:0006974|GO:0006401|GO:0043043|GO:0034622|GO:0051028|GO:0051169|GO:0006396|GO:0046782|GO:0003697|GO:0032774|GO:0034660|GO:2001141|GO:0045727|GO:0010608|GO:0006283|GO:0034402|GO:0006412|GO:0016071|GO:0006417|GO:0005665|GO:0006406|GO:0050434|GO:0016591|GO:0006405|GO:0003727|GO:0006351|GO:0000932|GO:0034587|GO:0006366|GO:0006913|GO:0006352|GO:0003899|GO:0006402|GO:0006354|GO:0006397|GO:0008380|GO:0031123|GO:0006367|GO:0006368|GO:0000375|GO:0051168|GO:0000956|GO:0006370|GO:0031124|GO:0009452|GO:0000398|GO:0000288 developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|viral process|DNA repair|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|ribonucleoprotein complex localization|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|response to heat|gene silencing|nucleobase-containing compound metabolic process|mRNA export from nucleus in response to heat stress|establishment of localization in cell|RNA localization|nucleotide binding|cellular biosynthetic process|response to temperature stimulus|ribonucleoprotein complex biogenesis|stem cell population maintenance|protein metabolic process|regulation of viral process|regulation of cellular metabolic process|translation initiation factor binding|ribonucleoprotein granule|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|gene silencing by RNA|negative regulation of gene expression|regulation of RNA metabolic process|regulation of translational initiation|cellular macromolecule catabolic process|positive regulation of gene expression|intracellular transport|viral transcription|ribonucleoprotein complex assembly|nuclear lumen|transferase complex|cellular response to heat|positive regulation of protein metabolic process|nucleoplasm|DNA metabolic process|somatic stem cell population maintenance|positive regulation of cellular protein metabolic process|RNA transport|cellular amide metabolic process|cellular protein metabolic process|positive regulation of viral life cycle|positive regulation of translational initiation|gene expression|viral life cycle|positive regulation of cellular biosynthetic process|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|nucleotidyltransferase activity|nucleotide-excision repair|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|cytoplasmic ribonucleoprotein granule|cellular response to DNA damage stimulus|RNA catabolic process|peptide biosynthetic process|cellular macromolecular complex assembly|mRNA transport|nuclear transport|RNA processing|regulation of viral transcription|single-stranded DNA binding|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|positive regulation of translation|posttranscriptional regulation of gene expression|transcription-coupled nucleotide-excision repair|recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex|translation|mRNA metabolic process|regulation of translation|DNA-directed RNA polymerase II, core complex|mRNA export from nucleus|positive regulation of viral transcription|DNA-directed RNA polymerase II, holoenzyme|RNA export from nucleus|single-stranded RNA binding|transcription, DNA-templated|cytoplasmic mRNA processing body|piRNA metabolic process|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|DNA-templated transcription, initiation|DNA-directed RNA polymerase activity|mRNA catabolic process|DNA-templated transcription, elongation|mRNA processing|RNA splicing|RNA 3'-end processing|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|RNA splicing, via transesterification reactions|nuclear export|nuclear-transcribed mRNA catabolic process|7-methylguanosine mRNA capping|mRNA 3'-end processing|7-methylguanosine RNA capping|mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K03012 DNA-directed RNA polymerase II subunit RPB4[-] hsa01100|hsa05169|hsa05016|hsa00230|hsa00240|hsa03020 Metabolic pathways - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|RNA polymerase - Homo sapiens (human) 2:127843551-127858157 3052 2837 2590 1310 1431 817 26.3761644205293 22.2826254087874 20.1809264235612 10.1436891525502 10.1469294808695 6.61725395010803 22.9465720842926 8.96929086117591 1.35521281909048 3.51723527761071e-09 7.0614352372421e-08 UP ENSG00000266074 BAHCC1 BAH domain and coiled-coil containing 1 [Source:HGNC Symbol;Acc:HGNC:29279] GO:0005488|GO:0044877|GO:0003682 binding|macromolecular complex binding|chromatin binding - - - - 17:81395475-81466332 372 543 462 1093 1238 1161 1.42608270722944 1.89182936557515 1.59683100967865 3.7542234762915 3.89395398596889 4.17122323749923 1.63824769416108 3.93980023325321 -1.2659689788543 3.55786476674168e-09 7.13820529209046e-08 DOWN ENSG00000077514 POLD3 polymerase (DNA-directed), delta 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:20932] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0051606|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0042769|GO:0016772|GO:0046483|GO:0033554|GO:0043231|GO:0000723|GO:0005737|GO:0042592|GO:0019725|GO:0006139|GO:0044249|GO:0006996|GO:0051276|GO:0034645|GO:0010833|GO:0019985|GO:0000722|GO:0006284|GO:0033260|GO:0000278|GO:0005657|GO:0031981|GO:0000731|GO:1990234|GO:0043625|GO:0006298|GO:0005654|GO:0006259|GO:0005739|GO:0005694|GO:0000228|GO:0032201|GO:0006301|GO:0009059|GO:0016779|GO:0006289|GO:0005634|GO:0006974|GO:0034061|GO:0032200|GO:0006260|GO:0043596|GO:0006297|GO:0022616|GO:0006283|GO:0070911|GO:0006310|GO:0033683|GO:0090305|GO:0071897|GO:0006271|GO:0006261|GO:0006312|GO:0003887 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|detection of stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|transferase activity|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|DNA damage response, detection of DNA damage|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|telomere maintenance|cytoplasm|homeostatic process|cellular homeostasis|nucleobase-containing compound metabolic process|cellular biosynthetic process|organelle organization|chromosome organization|cellular macromolecule biosynthetic process|telomere maintenance via telomere lengthening|translesion synthesis|telomere maintenance via recombination|base-excision repair|nuclear DNA replication|mitotic cell cycle|replication fork|nuclear lumen|DNA synthesis involved in DNA repair|transferase complex|delta DNA polymerase complex|mismatch repair|nucleoplasm|DNA metabolic process|mitochondrion|chromosome|nuclear chromosome|telomere maintenance via semi-conservative replication|postreplication repair|macromolecule biosynthetic process|nucleotidyltransferase activity|nucleotide-excision repair|nucleus|cellular response to DNA damage stimulus|DNA polymerase activity|telomere organization|DNA replication|nuclear replication fork|nucleotide-excision repair, DNA gap filling|DNA strand elongation|transcription-coupled nucleotide-excision repair|global genome nucleotide-excision repair|DNA recombination|nucleotide-excision repair, DNA incision|nucleic acid phosphodiester bond hydrolysis|DNA biosynthetic process|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication|mitotic recombination|DNA-directed DNA polymerase activity K03504 DNA polymerase delta subunit 3[-] hsa01100|hsa05166|hsa00230|hsa00240|hsa03420|hsa03030|hsa03410|hsa03440|hsa03430 Metabolic pathways - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Nucleotide excision repair - Homo sapiens (human)|DNA replication - Homo sapiens (human)|Base excision repair - Homo sapiens (human)|Homologous recombination - Homo sapiens (human)|Mismatch repair - Homo sapiens (human) 11:74493851-74669117 312 377 499 992 1082 917 2.64309767114503 2.90255608484635 3.8113070169986 7.5295436988003 7.52063108698413 7.28043644555819 3.11898692432999 7.44353707711421 -1.25491083063538 3.56971105689813e-09 7.15716278661093e-08 DOWN ENSG00000118655 DCLRE1B DNA cross-link repair 1B [Source:HGNC Symbol;Acc:HGNC:17641] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0033554|GO:0043231|GO:0000723|GO:0005737|GO:0042592|GO:0006139|GO:0006996|GO:0051276|GO:0003677|GO:0005813|GO:0000075|GO:0031627|GO:0005815|GO:0006302|GO:0036297|GO:0031981|GO:0004518|GO:0006259|GO:0005694|GO:0000228|GO:0016233|GO:0005856|GO:0005634|GO:0006974|GO:0043247|GO:0006303|GO:0032200|GO:0000781|GO:0004536|GO:0031860|GO:0022616|GO:0004527|GO:0003684|GO:0015630|GO:0031848|GO:0000784|GO:0090305|GO:0008409|GO:0035312 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|telomere maintenance|cytoplasm|homeostatic process|nucleobase-containing compound metabolic process|organelle organization|chromosome organization|DNA binding|centrosome|cell cycle checkpoint|telomeric loop formation|microtubule organizing center|double-strand break repair|interstrand cross-link repair|nuclear lumen|nuclease activity|DNA metabolic process|chromosome|nuclear chromosome|telomere capping|cytoskeleton|nucleus|cellular response to DNA damage stimulus|telomere maintenance in response to DNA damage|double-strand break repair via nonhomologous end joining|telomere organization|chromosome, telomeric region|deoxyribonuclease activity|telomeric 3' overhang formation|DNA strand elongation|exonuclease activity|damaged DNA binding|microtubule cytoskeleton|protection from non-homologous end joining at telomere|nuclear chromosome, telomeric region|nucleic acid phosphodiester bond hydrolysis|5'-3' exonuclease activity|5'-3' exodeoxyribonuclease activity - - - - 1:113905141-113914086 1758 1913 1724 904 955 688 17.8415162647673 17.6444420373815 15.7748194351683 8.22013876760649 7.95214294796214 6.54380267957713 17.086925912439 7.57202813171525 1.17414119080414 3.57326090842573e-09 7.15947188994239e-08 UP ENSG00000099290 FAM21A family with sequence similarity 21 member A [Source:HGNC Symbol;Acc:HGNC:23416] GO:0032991|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0008289|GO:0071944|GO:0005622|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0045184|GO:0071203|GO:0008104|GO:0051649|GO:0010008|GO:0005768|GO:0016192|GO:0005730|GO:0005769|GO:0015031|GO:0046907|GO:0031981|GO:0031901|GO:0005634|GO:0042147|GO:0016482|GO:0016197 macromolecular complex|cell|membrane|binding|intracellular organelle|cellular localization|membrane-bounded organelle|lipid binding|cell periphery|intracellular|plasma membrane|protein complex|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|WASH complex|protein localization|establishment of localization in cell|endosome membrane|endosome|vesicle-mediated transport|nucleolus|early endosome|protein transport|intracellular transport|nuclear lumen|early endosome membrane|nucleus|retrograde transport, endosome to Golgi|cytosolic transport|endosomal transport K18462 WASH complex subunit FAM21[-] hsa04144 Endocytosis - Homo sapiens (human) 10:50067888-50133506 283 291 364 754 872 752 2.99544502440367 2.79928704618691 3.47368101026786 7.15061497983723 7.57283866921389 7.45969721903782 3.08947102695281 7.39438362269631 -1.25907004897423 3.59133881551531e-09 7.19086713604253e-08 DOWN ENSG00000125347 IRF1 interferon regulatory factor 1 [Source:HGNC Symbol;Acc:HGNC:6116] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0002683|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0009628|GO:0044237|GO:0023051|GO:0000785|GO:0051707|GO:0007155|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0002757|GO:0051726|GO:0042127|GO:0002250|GO:0007049|GO:1903706|GO:0050817|GO:0016337|GO:0045087|GO:0045595|GO:0006725|GO:0070661|GO:0022402|GO:0009612|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0070489|GO:0034641|GO:0006952|GO:0030155|GO:0031325|GO:0046483|GO:0098542|GO:0001817|GO:0098609|GO:0045786|GO:0043231|GO:0005737|GO:0000981|GO:0002218|GO:0001816|GO:0009611|GO:0009615|GO:0001775|GO:0009966|GO:0009890|GO:0001819|GO:0010646|GO:0006139|GO:0007162|GO:0050776|GO:0000790|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0050778|GO:0008219|GO:0002695|GO:0008285|GO:0051607|GO:0048869|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0050878|GO:0032735|GO:0042107|GO:0000982|GO:0051249|GO:0005829|GO:0003677|GO:0034340|GO:0010468|GO:0034645|GO:0032943|GO:0042089|GO:0032479|GO:0007166|GO:0030097|GO:0002758|GO:0034097|GO:0030098|GO:0010629|GO:0007596|GO:0051252|GO:0034109|GO:0032655|GO:0007050|GO:0032481|GO:0010628|GO:0032615|GO:0042060|GO:0051250|GO:0022408|GO:0022407|GO:0034341|GO:0031981|GO:0007599|GO:0042035|GO:0007159|GO:0032606|GO:0051247|GO:0005654|GO:0005694|GO:0002764|GO:0000228|GO:0042108|GO:0042110|GO:0012501|GO:0010467|GO:0071310|GO:0002819|GO:0031328|GO:0051246|GO:0071260|GO:0046651|GO:0009059|GO:0030154|GO:0001228|GO:0034121|GO:0016070|GO:0010557|GO:0005634|GO:0045089|GO:0045088|GO:0002521|GO:1903038|GO:0000975|GO:0042098|GO:0045893|GO:0019221|GO:0035456|GO:0050863|GO:0045084|GO:0071346|GO:0045892|GO:0045620|GO:0032774|GO:0043565|GO:0050868|GO:0032728|GO:2001141|GO:0030217|GO:0001077|GO:0071357|GO:0045619|GO:1902679|GO:0002221|GO:0070486|GO:0003690|GO:0046631|GO:0032608|GO:0071345|GO:0045075|GO:0034124|GO:0034111|GO:0032648|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0036037|GO:1903507|GO:0002224|GO:0035458|GO:0060333|GO:0006357|GO:0046632|GO:0045580|GO:1903506|GO:0044212|GO:0045581|GO:0045066|GO:0042129|GO:0071593|GO:0060337|GO:0046633|GO:0045590|GO:0000976|GO:0001012|GO:0045589|GO:0002755|GO:0001159|GO:0035740|GO:0043374|GO:0000977|GO:0000987|GO:2000564|GO:0000978 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|response to abiotic stimulus|cellular metabolic process|regulation of signaling|chromatin|response to other organism|cell adhesion|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|immune response-activating signal transduction|regulation of cell cycle|regulation of cell proliferation|adaptive immune response|cell cycle|regulation of hemopoiesis|coagulation|single organismal cell-cell adhesion|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|leukocyte proliferation|cell cycle process|response to mechanical stimulus|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|defense response|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|defense response to other organism|regulation of cytokine production|cell-cell adhesion|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|cytokine production|response to wounding|response to virus|cell activation|regulation of signal transduction|negative regulation of biosynthetic process|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|negative regulation of cell adhesion|regulation of immune response|nuclear chromatin|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|positive regulation of immune response|cell death|negative regulation of leukocyte activation|negative regulation of cell proliferation|defense response to virus|cellular developmental process|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|positive regulation of interleukin-12 production|cytokine metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of lymphocyte activation|cytosol|DNA binding|response to type I interferon|regulation of gene expression|cellular macromolecule biosynthetic process|mononuclear cell proliferation|cytokine biosynthetic process|regulation of type I interferon production|cell surface receptor signaling pathway|hemopoiesis|innate immune response-activating signal transduction|response to cytokine|lymphocyte differentiation|negative regulation of gene expression|blood coagulation|regulation of RNA metabolic process|homotypic cell-cell adhesion|regulation of interleukin-12 production|cell cycle arrest|positive regulation of type I interferon production|positive regulation of gene expression|interleukin-12 production|wound healing|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|response to interferon-gamma|nuclear lumen|hemostasis|regulation of cytokine biosynthetic process|leukocyte cell-cell adhesion|type I interferon production|positive regulation of protein metabolic process|nucleoplasm|chromosome|immune response-regulating signaling pathway|nuclear chromosome|positive regulation of cytokine biosynthetic process|T cell activation|programmed cell death|gene expression|cellular response to organic substance|regulation of adaptive immune response|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cellular response to mechanical stimulus|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of toll-like receptor signaling pathway|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of innate immune response|regulation of innate immune response|leukocyte differentiation|negative regulation of leukocyte cell-cell adhesion|regulatory region DNA binding|T cell proliferation|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|response to interferon-beta|regulation of T cell activation|positive regulation of interleukin-12 biosynthetic process|cellular response to interferon-gamma|negative regulation of transcription, DNA-templated|negative regulation of lymphocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|negative regulation of T cell activation|positive regulation of interferon-beta production|regulation of RNA biosynthetic process|T cell differentiation|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cellular response to type I interferon|regulation of lymphocyte differentiation|negative regulation of RNA biosynthetic process|pattern recognition receptor signaling pathway|leukocyte aggregation|double-stranded DNA binding|alpha-beta T cell activation|interferon-beta production|cellular response to cytokine stimulus|regulation of interleukin-12 biosynthetic process|regulation of MyD88-dependent toll-like receptor signaling pathway|negative regulation of homotypic cell-cell adhesion|regulation of interferon-beta production|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|CD8-positive, alpha-beta T cell activation|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|cellular response to interferon-beta|interferon-gamma-mediated signaling pathway|regulation of transcription from RNA polymerase II promoter|alpha-beta T cell differentiation|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of T cell differentiation|regulatory T cell differentiation|regulation of T cell proliferation|lymphocyte aggregation|type I interferon signaling pathway|alpha-beta T cell proliferation|negative regulation of regulatory T cell differentiation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|regulation of regulatory T cell differentiation|MyD88-dependent toll-like receptor signaling pathway|core promoter proximal region DNA binding|CD8-positive, alpha-beta T cell proliferation|CD8-positive, alpha-beta T cell differentiation|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|regulation of CD8-positive, alpha-beta T cell proliferation|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09444 interferon regulatory factor 1[-] hsa05160|hsa05133|hsa04917 Hepatitis C - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human) 5:132481609-132490798 342 390 443 134 150 193 1.79253148817455 1.85774367665626 2.09343332667678 0.629281103769092 0.645058258000312 0.948041697033109 1.9145694971692 0.740793686267504 1.36987632191006 3.67155062564221e-09 7.34648825206173e-08 UP ENSG00000198517 MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K [Source:HGNC Symbol;Acc:HGNC:6782] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0050817|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0009611|GO:0019904|GO:0006139|GO:0008134|GO:0044249|GO:0031323|GO:0050878|GO:0003677|GO:0010468|GO:0034645|GO:0007596|GO:0051252|GO:0010628|GO:0071535|GO:0042060|GO:0031981|GO:0007599|GO:0005654|GO:0001221|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0000976 developmental process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|coagulation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|response to wounding|protein domain specific binding|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|regulation of cellular metabolic process|regulation of body fluid levels|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|blood coagulation|regulation of RNA metabolic process|positive regulation of gene expression|RING-like zinc finger domain binding|wound healing|nuclear lumen|hemostasis|nucleoplasm|transcription cofactor binding|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding - - - - 7:1530714-1543043 2172 2323 1366 491 565 892 23.2330946477991 22.5827333588815 13.1738317833787 4.70572216534963 4.95864841615294 8.94212749670599 19.6632199300198 6.20216602606952 1.6646555368913 3.67398236763186e-09 7.34648825206173e-08 UP ENSG00000006715 VPS41 VPS41 HOPS complex subunit [Source:HGNC Symbol;Acc:HGNC:12713] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0044877|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0042802|GO:0030119|GO:0006810|GO:0060627|GO:0032940|GO:0031982|GO:0051128|GO:0071439|GO:0022607|GO:0030117|GO:0043231|GO:0043169|GO:0019899|GO:0005774|GO:0005737|GO:0033263|GO:0032403|GO:0045184|GO:0008104|GO:0061024|GO:0043621|GO:0051649|GO:0008092|GO:0010008|GO:0030897|GO:0043254|GO:0005794|GO:0005768|GO:0006996|GO:0061025|GO:0016192|GO:0015631|GO:0005829|GO:0005798|GO:0046872|GO:0016050|GO:0072594|GO:0031410|GO:0005769|GO:0042144|GO:0015031|GO:0005773|GO:0008017|GO:0016023|GO:0006887|GO:0046907|GO:0005770|GO:0031988|GO:0006461|GO:0035542|GO:0034613|GO:0030118|GO:0033043|GO:0031338|GO:0046903|GO:0030123|GO:0051020|GO:0005856|GO:0031902|GO:0007033|GO:0048284|GO:0006623|GO:0033365|GO:0045055|GO:0034622|GO:0000323|GO:0043623|GO:0006605|GO:0048193|GO:0006886|GO:0006906|GO:0030135|GO:0015630|GO:0016197|GO:0046914|GO:0072666|GO:0007034|GO:0005765|GO:0030136|GO:0008333|GO:0007041|GO:0005764|GO:0045324|GO:0034058|GO:0035493|GO:0008270|GO:1902774 macromolecular complex|cell|membrane|cellular process|binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|ion binding|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|identical protein binding|AP-type membrane coat adaptor complex|transport|regulation of vesicle-mediated transport|secretion by cell|vesicle|regulation of cellular component organization|clathrin complex|cellular component assembly|membrane coat|intracellular membrane-bounded organelle|cation binding|enzyme binding|vacuolar membrane|cytoplasm|CORVET complex|protein complex binding|establishment of protein localization|protein localization|membrane organization|protein self-association|establishment of localization in cell|cytoskeletal protein binding|endosome membrane|HOPS complex|regulation of protein complex assembly|Golgi apparatus|endosome|organelle organization|membrane fusion|vesicle-mediated transport|tubulin binding|cytosol|Golgi-associated vesicle|metal ion binding|vesicle organization|establishment of protein localization to organelle|cytoplasmic vesicle|early endosome|vacuole fusion, non-autophagic|protein transport|vacuole|microtubule binding|cytoplasmic, membrane-bounded vesicle|exocytosis|intracellular transport|late endosome|membrane-bounded vesicle|protein complex assembly|regulation of SNARE complex assembly|cellular protein localization|clathrin coat|regulation of organelle organization|regulation of vesicle fusion|secretion|AP-3 adaptor complex|GTPase binding|cytoskeleton|late endosome membrane|vacuole organization|organelle fusion|protein targeting to vacuole|protein localization to organelle|regulated exocytosis|cellular macromolecular complex assembly|lytic vacuole|cellular protein complex assembly|protein targeting|Golgi vesicle transport|intracellular protein transport|vesicle fusion|coated vesicle|microtubule cytoskeleton|endosomal transport|transition metal ion binding|establishment of protein localization to vacuole|vacuolar transport|lysosomal membrane|clathrin-coated vesicle|endosome to lysosome transport|lysosomal transport|lysosome|late endosome to vacuole transport|endosomal vesicle fusion|SNARE complex assembly|zinc ion binding|late endosome to lysosome transport - - - - 7:38722963-38932394 268 338 477 999 972 878 1.92657075837845 2.20824269336641 3.09160195085004 6.43448412541914 5.7330390616654 5.91526607557706 2.4088051341983 6.0275964208872 -1.32326513600792 3.68464955727492e-09 7.36288673914897e-08 DOWN ENSG00000030110 BAK1 BCL2-antagonist/killer 1 [Source:HGNC Symbol;Acc:HGNC:949] GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0019835|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0051641|GO:0003006|GO:0001776|GO:0023051|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0019867|GO:0002262|GO:0009607|GO:0009605|GO:0009893|GO:0031224|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0042802|GO:0048514|GO:0060341|GO:0051726|GO:0042127|GO:0007049|GO:0042391|GO:0009791|GO:0048569|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0009314|GO:0044325|GO:0006810|GO:0035295|GO:0051130|GO:0009612|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0010524|GO:0048513|GO:0034641|GO:0043270|GO:0031325|GO:0046483|GO:0051128|GO:1902742|GO:0033554|GO:0007420|GO:0010942|GO:0051098|GO:0043231|GO:0048608|GO:0051087|GO:0043169|GO:0009620|GO:0005737|GO:0007389|GO:0001763|GO:0060322|GO:0007423|GO:0009887|GO:0042592|GO:0031018|GO:0001775|GO:0009966|GO:0048729|GO:0046983|GO:0007548|GO:0031966|GO:0048771|GO:0019725|GO:0060561|GO:0006979|GO:0019904|GO:0042493|GO:0046930|GO:0032388|GO:0010646|GO:0006139|GO:0043085|GO:0001525|GO:0046649|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0005783|GO:0002260|GO:0002352|GO:0090559|GO:0051649|GO:2000021|GO:0008219|GO:0008285|GO:0031016|GO:0050790|GO:0031072|GO:0048869|GO:0016021|GO:0048806|GO:0010035|GO:0009967|GO:0019538|GO:0031301|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0007568|GO:0009636|GO:0061025|GO:2001235|GO:0032268|GO:0005740|GO:0005829|GO:0008053|GO:0042113|GO:0030540|GO:0010468|GO:0046872|GO:0007166|GO:0001654|GO:0030968|GO:0002009|GO:0001569|GO:0001944|GO:0043412|GO:0061458|GO:0030097|GO:0072358|GO:0030098|GO:0007417|GO:0051345|GO:0042542|GO:0010629|GO:0010623|GO:0007005|GO:0005741|GO:0046982|GO:0048878|GO:0031100|GO:0032386|GO:0048754|GO:0051604|GO:0061138|GO:1900101|GO:0032075|GO:0010046|GO:0051347|GO:0036211|GO:0032269|GO:0046902|GO:0046907|GO:0048872|GO:0006811|GO:0055082|GO:0048563|GO:0001782|GO:0031306|GO:0006986|GO:0035270|GO:0051400|GO:0071478|GO:0051247|GO:0006508|GO:0005739|GO:0001974|GO:0051881|GO:0043269|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0000302|GO:0006796|GO:1901030|GO:0032592|GO:0010212|GO:0035556|GO:0031077|GO:0033043|GO:0035108|GO:0044267|GO:0051174|GO:0010467|GO:0007399|GO:0060562|GO:0071310|GO:1902262|GO:0051246|GO:0071260|GO:0010522|GO:0030154|GO:0060173|GO:0043068|GO:0035967|GO:0051928|GO:0072359|GO:0034976|GO:0009416|GO:0042803|GO:0043067|GO:0097305|GO:0006974|GO:1900103|GO:0097190|GO:0048284|GO:0007006|GO:0034220|GO:0043393|GO:0010638|GO:0060068|GO:0034620|GO:0070059|GO:0002521|GO:0048050|GO:1901028|GO:0010332|GO:0097193|GO:0031401|GO:0010248|GO:0043065|GO:0009411|GO:0043496|GO:0036498|GO:0030183|GO:0016485|GO:0043010|GO:0006839|GO:0030162|GO:0006812|GO:0097192|GO:0008637|GO:0045862|GO:0016310|GO:0052547|GO:0060402|GO:0010822|GO:1903894|GO:0016482|GO:0048597|GO:0045471|GO:0097345|GO:0090200|GO:1902108|GO:0035794|GO:0010821|GO:0008630|GO:0071482|GO:0001836|GO:1903896|GO:0042981|GO:0050801|GO:0043497|GO:0031307|GO:0006464|GO:0010952|GO:0097191|GO:0006987|GO:0043549|GO:0006915|GO:0006873|GO:0048592|GO:0033674|GO:0044346|GO:0045859|GO:0010950|GO:0045860|GO:0048593|GO:0043281|GO:0006468|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:1902110|GO:0031638|GO:0030001|GO:0043280|GO:0001934|GO:0006919|GO:0051924|GO:0001933|GO:0034644|GO:0030003|GO:0042327|GO:0010225|GO:0052548|GO:0033137|GO:2001056|GO:0055065|GO:0006875|GO:0018105|GO:0008635|GO:0033135|GO:2000116|GO:0097202|GO:0070231|GO:0006874|GO:0006816|GO:0055074|GO:0001783|GO:0070242|GO:0051480|GO:0032469|GO:0060401|GO:0032471|GO:0007204 developmental process|macromolecular complex|reproduction|immune system process|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|cytolysis|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular localization|developmental process involved in reproduction|leukocyte homeostasis|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|outer membrane|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|intracellular|immune system development|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|regulation of cellular localization|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of membrane potential|post-embryonic development|post-embryonic organ development|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|response to radiation|ion channel binding|transport|tube development|positive regulation of cellular component organization|response to mechanical stimulus|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|positive regulation of calcium ion transport into cytosol|animal organ development|cellular nitrogen compound metabolic process|positive regulation of ion transport|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|apoptotic process involved in development|cellular response to stress|brain development|positive regulation of cell death|regulation of binding|intracellular membrane-bounded organelle|reproductive structure development|chaperone binding|cation binding|response to fungus|cytoplasm|pattern specification process|morphogenesis of a branching structure|head development|sensory organ development|organ morphogenesis|homeostatic process|endocrine pancreas development|cell activation|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|sex differentiation|mitochondrial membrane|tissue remodeling|cellular homeostasis|apoptotic process involved in morphogenesis|response to oxidative stress|protein domain specific binding|response to drug|pore complex|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|angiogenesis|lymphocyte activation|cell communication|transmembrane transport|membrane organization|signal transduction|endoplasmic reticulum|lymphocyte homeostasis|B cell negative selection|regulation of membrane permeability|establishment of localization in cell|regulation of ion homeostasis|cell death|negative regulation of cell proliferation|pancreas development|regulation of catalytic activity|heat shock protein binding|cellular developmental process|integral component of membrane|genitalia development|response to inorganic substance|positive regulation of signal transduction|protein metabolic process|integral component of organelle membrane|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|aging|response to toxic substance|membrane fusion|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|mitochondrial envelope|cytosol|mitochondrial fusion|B cell activation|female genitalia development|regulation of gene expression|metal ion binding|cell surface receptor signaling pathway|eye development|endoplasmic reticulum unfolded protein response|morphogenesis of an epithelium|patterning of blood vessels|vasculature development|macromolecule modification|reproductive system development|hemopoiesis|cardiovascular system development|lymphocyte differentiation|central nervous system development|positive regulation of hydrolase activity|response to hydrogen peroxide|negative regulation of gene expression|developmental programmed cell death|mitochondrion organization|mitochondrial outer membrane|protein heterodimerization activity|chemical homeostasis|organ regeneration|regulation of intracellular transport|branching morphogenesis of an epithelial tube|protein maturation|morphogenesis of a branching epithelium|regulation of endoplasmic reticulum unfolded protein response|positive regulation of nuclease activity|response to mycotoxin|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of mitochondrial membrane permeability|intracellular transport|homeostasis of number of cells|ion transport|cellular chemical homeostasis|post-embryonic organ morphogenesis|B cell homeostasis|intrinsic component of mitochondrial outer membrane|response to unfolded protein|endocrine system development|BH domain binding|cellular response to radiation|positive regulation of protein metabolic process|proteolysis|mitochondrion|blood vessel remodeling|regulation of mitochondrial membrane potential|regulation of ion transport|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|response to reactive oxygen species|phosphate-containing compound metabolic process|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|integral component of mitochondrial membrane|response to ionizing radiation|intracellular signal transduction|post-embryonic camera-type eye development|regulation of organelle organization|limb morphogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|apoptotic process involved in patterning of blood vessels|regulation of protein metabolic process|cellular response to mechanical stimulus|regulation of calcium ion transport into cytosol|cell differentiation|limb development|positive regulation of programmed cell death|cellular response to topologically incorrect protein|positive regulation of calcium ion transport|circulatory system development|response to endoplasmic reticulum stress|response to light stimulus|protein homodimerization activity|regulation of programmed cell death|response to alcohol|cellular response to DNA damage stimulus|positive regulation of endoplasmic reticulum unfolded protein response|apoptotic signaling pathway|organelle fusion|mitochondrial membrane organization|ion transmembrane transport|regulation of protein binding|positive regulation of organelle organization|vagina development|cellular response to unfolded protein|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|leukocyte differentiation|post-embryonic eye morphogenesis|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|response to gamma radiation|intrinsic apoptotic signaling pathway|positive regulation of protein modification process|establishment or maintenance of transmembrane electrochemical gradient|positive regulation of apoptotic process|response to UV|regulation of protein homodimerization activity|IRE1-mediated unfolded protein response|B cell differentiation|protein processing|camera-type eye development|mitochondrial transport|regulation of proteolysis|cation transport|extrinsic apoptotic signaling pathway in absence of ligand|apoptotic mitochondrial changes|positive regulation of proteolysis|phosphorylation|regulation of peptidase activity|calcium ion transport into cytosol|positive regulation of mitochondrion organization|regulation of IRE1-mediated unfolded protein response|cytosolic transport|post-embryonic camera-type eye morphogenesis|response to ethanol|mitochondrial outer membrane permeabilization|positive regulation of release of cytochrome c from mitochondria|regulation of mitochondrial membrane permeability involved in apoptotic process|positive regulation of mitochondrial membrane permeability|regulation of mitochondrion organization|intrinsic apoptotic signaling pathway in response to DNA damage|cellular response to light stimulus|release of cytochrome c from mitochondria|positive regulation of IRE1-mediated unfolded protein response|regulation of apoptotic process|ion homeostasis|regulation of protein heterodimerization activity|integral component of mitochondrial outer membrane|cellular protein modification process|positive regulation of peptidase activity|extrinsic apoptotic signaling pathway|activation of signaling protein activity involved in unfolded protein response|regulation of kinase activity|apoptotic process|cellular ion homeostasis|eye morphogenesis|positive regulation of kinase activity|fibroblast apoptotic process|regulation of protein kinase activity|positive regulation of endopeptidase activity|positive regulation of protein kinase activity|camera-type eye morphogenesis|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|positive regulation of mitochondrial membrane permeability involved in apoptotic process|zymogen activation|metal ion transport|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of calcium ion transport|negative regulation of protein phosphorylation|cellular response to UV|cellular cation homeostasis|positive regulation of phosphorylation|response to UV-C|regulation of endopeptidase activity|negative regulation of peptidyl-serine phosphorylation|positive regulation of cysteine-type endopeptidase activity|metal ion homeostasis|cellular metal ion homeostasis|peptidyl-serine phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|regulation of peptidyl-serine phosphorylation|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|T cell apoptotic process|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|B cell apoptotic process|thymocyte apoptotic process|regulation of cytosolic calcium ion concentration|endoplasmic reticulum calcium ion homeostasis|cytosolic calcium ion transport|negative regulation of endoplasmic reticulum calcium ion concentration|positive regulation of cytosolic calcium ion concentration K14021 Bcl-2 homologous antagonist/killer[-] hsa05206|hsa05203|hsa04141|hsa04210 MicroRNAs in cancer - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|Apoptosis - Homo sapiens (human) 6:33572547-33580293 1089 1063 1124 532 615 486 19.9462613340929 17.6948455163191 18.5615384490941 8.73056951295164 9.24222755228106 8.34254057699221 18.7342150998354 8.77177921407497 1.09473412998991 3.6885123267023e-09 7.36567538470706e-08 UP ENSG00000001084 GCLC glutamate-cysteine ligase, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:4311] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0023051|GO:0016043|GO:0048037|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006575|GO:0042391|GO:0006725|GO:1901360|GO:0010941|GO:0006082|GO:0009410|GO:0046685|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0031325|GO:0046483|GO:0051409|GO:0043169|GO:0005737|GO:0006520|GO:0003254|GO:0009408|GO:0005975|GO:0042592|GO:0043177|GO:0009966|GO:0046983|GO:0009890|GO:0019725|GO:0006979|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:2000021|GO:0009725|GO:0008219|GO:0050662|GO:0006805|GO:0000166|GO:0016021|GO:0044249|GO:0009266|GO:0045454|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0003013|GO:0006996|GO:0006790|GO:0032268|GO:0005829|GO:0045732|GO:0035150|GO:0010468|GO:0034645|GO:1901215|GO:0006518|GO:0046872|GO:0007166|GO:0051899|GO:0035639|GO:0051900|GO:0043412|GO:0030163|GO:0010629|GO:0007005|GO:0043069|GO:2001234|GO:0046982|GO:0048878|GO:0017109|GO:0051252|GO:0001883|GO:0070997|GO:0044265|GO:0016881|GO:0036211|GO:0032269|GO:0000096|GO:0032549|GO:0043531|GO:0071466|GO:0005996|GO:0051247|GO:0006749|GO:0006508|GO:1901214|GO:0051881|GO:0032270|GO:0012501|GO:0043603|GO:0044267|GO:0031406|GO:0042176|GO:0010467|GO:0017076|GO:0051246|GO:0009059|GO:1901687|GO:0016070|GO:0008015|GO:0043067|GO:0097190|GO:0006766|GO:2001237|GO:0044257|GO:0043043|GO:0010498|GO:0045892|GO:0043523|GO:0000287|GO:0032774|GO:1903364|GO:0005524|GO:0030162|GO:2001141|GO:0008637|GO:0045862|GO:2001236|GO:0030554|GO:0051882|GO:1902679|GO:0051603|GO:0006534|GO:0042981|GO:0050801|GO:0016597|GO:0043066|GO:0019752|GO:0004357|GO:0051402|GO:0043524|GO:0009069|GO:0006464|GO:0019852|GO:0006767|GO:0097191|GO:0006750|GO:0006351|GO:0006915|GO:0006355|GO:0050880|GO:1903507|GO:1903052|GO:0043648|GO:0019941|GO:0016595|GO:1903506|GO:1901800|GO:0061136|GO:0043161|GO:0006536|GO:0032446|GO:0006511|GO:0031396|GO:0032434|GO:0031397|GO:0032436|GO:0016567 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|cellular component organization|cofactor binding|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|ligase activity|intracellular|protein binding|protein complex|regulation of metabolic process|cellular modified amino acid metabolic process|regulation of membrane potential|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|response to xenobiotic stimulus|response to arsenic-containing substance|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|response to nitrosative stress|cation binding|cytoplasm|cellular amino acid metabolic process|regulation of membrane depolarization|response to heat|carbohydrate metabolic process|homeostatic process|organic acid binding|regulation of signal transduction|protein dimerization activity|negative regulation of biosynthetic process|cellular homeostasis|response to oxidative stress|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|regulation of ion homeostasis|response to hormone|cell death|coenzyme binding|xenobiotic metabolic process|nucleotide binding|integral component of membrane|cellular biosynthetic process|response to temperature stimulus|cell redox homeostasis|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|organelle organization|sulfur compound metabolic process|regulation of cellular protein metabolic process|cytosol|positive regulation of protein catabolic process|regulation of tube size|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of neuron death|peptide metabolic process|metal ion binding|cell surface receptor signaling pathway|membrane depolarization|purine ribonucleoside triphosphate binding|regulation of mitochondrial depolarization|macromolecule modification|protein catabolic process|negative regulation of gene expression|mitochondrion organization|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|protein heterodimerization activity|chemical homeostasis|glutamate-cysteine ligase complex|regulation of RNA metabolic process|purine nucleoside binding|neuron death|cellular macromolecule catabolic process|acid-amino acid ligase activity|protein modification process|negative regulation of cellular protein metabolic process|sulfur amino acid metabolic process|ribonucleoside binding|ADP binding|cellular response to xenobiotic stimulus|monosaccharide metabolic process|positive regulation of protein metabolic process|glutathione metabolic process|proteolysis|regulation of neuron death|regulation of mitochondrial membrane potential|positive regulation of cellular protein metabolic process|programmed cell death|cellular amide metabolic process|cellular protein metabolic process|carboxylic acid binding|regulation of protein catabolic process|gene expression|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|glutathione derivative biosynthetic process|RNA metabolic process|blood circulation|regulation of programmed cell death|apoptotic signaling pathway|vitamin metabolic process|negative regulation of extrinsic apoptotic signaling pathway|cellular protein catabolic process|peptide biosynthetic process|proteasomal protein catabolic process|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|magnesium ion binding|RNA biosynthetic process|positive regulation of cellular protein catabolic process|ATP binding|regulation of proteolysis|regulation of RNA biosynthetic process|apoptotic mitochondrial changes|positive regulation of proteolysis|regulation of extrinsic apoptotic signaling pathway|adenyl nucleotide binding|mitochondrial depolarization|negative regulation of RNA biosynthetic process|proteolysis involved in cellular protein catabolic process|cysteine metabolic process|regulation of apoptotic process|ion homeostasis|amino acid binding|negative regulation of apoptotic process|carboxylic acid metabolic process|glutamate-cysteine ligase activity|neuron apoptotic process|negative regulation of neuron apoptotic process|serine family amino acid metabolic process|cellular protein modification process|L-ascorbic acid metabolic process|water-soluble vitamin metabolic process|extrinsic apoptotic signaling pathway|glutathione biosynthetic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of blood vessel size|negative regulation of nucleic acid-templated transcription|positive regulation of proteolysis involved in cellular protein catabolic process|dicarboxylic acid metabolic process|modification-dependent protein catabolic process|glutamate binding|regulation of nucleic acid-templated transcription|positive regulation of proteasomal protein catabolic process|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|glutamate metabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination K11204 glutamate--cysteine ligase catalytic subunit[6.3.2.2] hsa01100|hsa00480|hsa00270 Metabolic pathways - Homo sapiens (human)|Glutathione metabolism - Homo sapiens (human)|Cysteine and methionine metabolism - Homo sapiens (human) 6:53497341-53616970 841 972 1048 2271 2606 2111 4.2538202551867 4.46816721274017 4.77923940188477 10.291961054352 10.8149762380137 10.0069193538229 4.50040895660388 10.3712855487295 -1.20446671953019 3.7050690079552e-09 7.39379212322826e-08 DOWN ENSG00000140265 ZSCAN29 zinc finger and SCAN domain containing 29 [Source:HGNC Symbol;Acc:HGNC:26673] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0000981|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 15:43358172-43371025 1013 1185 842 457 479 453 5.82904461436676 6.19706696800382 4.36831677099197 2.35614217921067 2.26147034032991 2.44294964970939 5.46480945112085 2.35352072308332 1.21535063616377 3.72198453246147e-09 7.42258692265228e-08 UP ENSG00000003147 ICA1 islet cell autoantigen 1 [Source:HGNC Symbol;Acc:HGNC:5343] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0042995|GO:0030672|GO:0008021|GO:0050794|GO:0043229|GO:0051641|GO:0023051|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0060341|GO:0006810|GO:0032940|GO:0031982|GO:0051098|GO:0030141|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0032880|GO:0012506|GO:0043005|GO:0045184|GO:0046883|GO:0036477|GO:0030658|GO:0019904|GO:0010646|GO:0008104|GO:0007154|GO:0030667|GO:0010817|GO:0016021|GO:0005794|GO:0006836|GO:0005829|GO:0090276|GO:0031410|GO:0051223|GO:0015031|GO:0016023|GO:0070201|GO:0070382|GO:0042886|GO:0051046|GO:0030425|GO:0009914|GO:0009306|GO:0048471|GO:0031988|GO:0030659|GO:0005795|GO:0046903|GO:0000139|GO:0043393|GO:0050796|GO:0002790|GO:0030073|GO:0043496|GO:0050708|GO:0015833|GO:0046879|GO:0030072 synapse|signaling|cell|membrane|cellular process|cell junction|binding|cell projection|synaptic vesicle membrane|synaptic vesicle|regulation of cellular process|intracellular organelle|cellular localization|regulation of signaling|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|regulation of cellular localization|transport|secretion by cell|vesicle|regulation of binding|secretory granule|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|regulation of protein localization|vesicle membrane|neuron projection|establishment of protein localization|regulation of hormone secretion|somatodendritic compartment|transport vesicle membrane|protein domain specific binding|regulation of cell communication|protein localization|cell communication|secretory granule membrane|regulation of hormone levels|integral component of membrane|Golgi apparatus|neurotransmitter transport|cytosol|regulation of peptide hormone secretion|cytoplasmic vesicle|regulation of protein transport|protein transport|cytoplasmic, membrane-bounded vesicle|regulation of establishment of protein localization|exocytic vesicle|amide transport|regulation of secretion|dendrite|hormone transport|protein secretion|perinuclear region of cytoplasm|membrane-bounded vesicle|cytoplasmic vesicle membrane|Golgi stack|secretion|Golgi membrane|regulation of protein binding|regulation of insulin secretion|peptide secretion|insulin secretion|regulation of protein homodimerization activity|regulation of protein secretion|peptide transport|hormone secretion|peptide hormone secretion K19863 islet cell auto antigen 1[-] hsa04940 Type I diabetes mellitus - Homo sapiens (human) 7:8113184-8262687 84 89 181 373 420 442 0.60342077093952 0.581050097460653 1.17228872182526 2.40075724024564 2.47547838136195 2.97572522879784 0.785586530075144 2.61732028346848 -1.73624838082129 3.75163553853856e-09 7.47672412333312e-08 DOWN ENSG00000052749 RRP12 ribosomal RNA processing 12 homolog [Source:HGNC Symbol;Acc:HGNC:29100] GO:0005623|GO:0016020|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0003676|GO:0043231|GO:0005635|GO:0031965|GO:0016021|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|membrane|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|nucleic acid binding|intracellular membrane-bounded organelle|nuclear envelope|nuclear membrane|integral component of membrane|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 10:97356358-97426076 1780 1816 1335 701 836 543 10.5639376634983 9.79494279079934 7.14333948701756 3.72753342557329 4.07080582053047 3.02019236614872 9.16740664710507 3.60617720408416 1.34604337869964 3.83140100513394e-09 7.63059677166568e-08 UP ENSG00000153944 MSI2 musashi RNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:18585] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0005622|GO:0005515|GO:0048856|GO:0048468|GO:0003676|GO:0005737|GO:0030529|GO:0000166|GO:0048869|GO:0003723|GO:0005844|GO:0048864|GO:0030154|GO:0048863|GO:0044822|GO:0003727|GO:0008187|GO:0008266 developmental process|macromolecular complex|cell|cellular process|binding|small molecule binding|organic cyclic compound binding|intracellular|protein binding|anatomical structure development|cell development|nucleic acid binding|cytoplasm|intracellular ribonucleoprotein complex|nucleotide binding|cellular developmental process|RNA binding|polysome|stem cell development|cell differentiation|stem cell differentiation|poly(A) RNA binding|single-stranded RNA binding|poly-pyrimidine tract binding|poly(U) RNA binding K14411 RNA-binding protein Musashi[-] hsa03015 mRNA surveillance pathway - Homo sapiens (human) 17:57255851-57684685 446 545 737 1359 1457 1810 1.17063550336762 1.30005974240262 1.74408866334077 3.1959800116527 3.13772253741267 4.45240407117832 1.40492796970367 3.59536887341456 -1.35564362844418 3.8372595504709e-09 7.63716977465055e-08 DOWN ENSG00000166900 STX3 syntaxin 3 [Source:HGNC Symbol;Acc:HGNC:11438] GO:0040011|GO:0032502|GO:0032991|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0031629|GO:0042995|GO:0008021|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0016079|GO:0048520|GO:0043167|GO:0051641|GO:0050795|GO:0045177|GO:0023051|GO:0005911|GO:0040017|GO:0016043|GO:0030427|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0031252|GO:0031224|GO:0005622|GO:0007269|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0016081|GO:0012505|GO:0048856|GO:0060341|GO:0008284|GO:0031201|GO:0042127|GO:0050804|GO:0006935|GO:0005504|GO:0051640|GO:0048468|GO:0006810|GO:0051130|GO:0016324|GO:0007275|GO:0043168|GO:0032940|GO:0030155|GO:0031982|GO:0051128|GO:0030426|GO:0050806|GO:0050803|GO:0030141|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0050920|GO:0032880|GO:0051656|GO:0043177|GO:2000010|GO:0022406|GO:0043005|GO:0030027|GO:0005484|GO:0045184|GO:0036477|GO:0010646|GO:0000149|GO:0008104|GO:0007154|GO:0061024|GO:0070062|GO:0051649|GO:0045785|GO:0001505|GO:0030030|GO:0048869|GO:0016021|GO:0010256|GO:0050921|GO:0006996|GO:0061025|GO:0016192|GO:0006836|GO:0051650|GO:0048278|GO:0031175|GO:0048167|GO:0016050|GO:0031410|GO:0042581|GO:0015031|GO:0048489|GO:0005773|GO:0007009|GO:0016023|GO:0006887|GO:0070382|GO:0046907|GO:0072657|GO:0030425|GO:0031988|GO:0034613|GO:0060291|GO:1903078|GO:0031406|GO:0050544|GO:0007399|GO:0046903|GO:0051648|GO:0036041|GO:0030154|GO:1903827|GO:0042582|GO:0048284|GO:0048666|GO:0030182|GO:2000008|GO:0045055|GO:0006904|GO:0000323|GO:0072659|GO:0045026|GO:0034394|GO:0016482|GO:0006886|GO:0050543|GO:0006906|GO:1903076|GO:0022008|GO:1990778|GO:0005764|GO:0048699|GO:0017156|GO:0007268 locomotion|developmental process|macromolecular complex|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|small molecule binding|extracellular vesicle|synaptic vesicle fusion to presynaptic active zone membrane|cell projection|synaptic vesicle|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|synaptic vesicle exocytosis|positive regulation of behavior|ion binding|cellular localization|regulation of behavior|apical part of cell|regulation of signaling|cell-cell junction|positive regulation of locomotion|cellular component organization|site of polarized growth|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|cell leading edge|intrinsic component of membrane|intracellular|neurotransmitter secretion|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|synaptic vesicle docking|endomembrane system|anatomical structure development|regulation of cellular localization|positive regulation of cell proliferation|SNARE complex|regulation of cell proliferation|modulation of synaptic transmission|chemotaxis|fatty acid binding|organelle localization|cell development|transport|positive regulation of cellular component organization|apical plasma membrane|multicellular organism development|anion binding|secretion by cell|regulation of cell adhesion|vesicle|regulation of cellular component organization|growth cone|positive regulation of synaptic transmission|regulation of synapse structure or activity|secretory granule|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|regulation of chemotaxis|regulation of protein localization|establishment of organelle localization|organic acid binding|positive regulation of protein localization to cell surface|membrane docking|neuron projection|lamellipodium|SNAP receptor activity|establishment of protein localization|somatodendritic compartment|regulation of cell communication|SNARE binding|protein localization|cell communication|membrane organization|extracellular exosome|establishment of localization in cell|positive regulation of cell adhesion|regulation of neurotransmitter levels|cell projection organization|cellular developmental process|integral component of membrane|endomembrane system organization|positive regulation of chemotaxis|organelle organization|membrane fusion|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|vesicle docking|neuron projection development|regulation of synaptic plasticity|vesicle organization|cytoplasmic vesicle|specific granule|protein transport|synaptic vesicle transport|vacuole|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|exocytosis|exocytic vesicle|intracellular transport|protein localization to membrane|dendrite|membrane-bounded vesicle|cellular protein localization|long-term synaptic potentiation|positive regulation of protein localization to plasma membrane|carboxylic acid binding|arachidonic acid binding|nervous system development|secretion|vesicle localization|long-chain fatty acid binding|cell differentiation|regulation of cellular protein localization|azurophil granule|organelle fusion|neuron development|neuron differentiation|regulation of protein localization to cell surface|regulated exocytosis|vesicle docking involved in exocytosis|lytic vacuole|protein localization to plasma membrane|plasma membrane fusion|protein localization to cell surface|cytosolic transport|intracellular protein transport|icosatetraenoic acid binding|vesicle fusion|regulation of protein localization to plasma membrane|neurogenesis|protein localization to cell periphery|lysosome|generation of neurons|calcium ion regulated exocytosis|synaptic transmission K08486 syntaxin 1B/2/3[-] hsa04721|hsa04130 Synaptic vesicle cycle - Homo sapiens (human)|SNARE interactions in vesicular transport - Homo sapiens (human) 11:59713456-59805882 2326 2263 2221 1150 1206 990 16.008356433796 14.1547360943315 13.7816062415906 7.09141311595662 6.81008263915973 6.38559431637847 14.6482329232394 6.76236335716494 1.11512719417757 3.8710855911079e-09 7.69935970932279e-08 UP ENSG00000171451 DSEL dermatan sulfate epimerase-like [Source:HGNC Symbol;Acc:HGNC:18144] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016853|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0016854|GO:0006082|GO:0044281|GO:0043231|GO:0005737|GO:0005975|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0034645|GO:0030204|GO:0009100|GO:1901137|GO:0008146|GO:0000139|GO:0016857|GO:0030205|GO:0009059|GO:0009101|GO:0030208|GO:0047757|GO:0006024|GO:0006029|GO:0019752|GO:0030203|GO:0050655|GO:0032787|GO:0030166|GO:0050651 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|isomerase activity|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|racemase and epimerase activity|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|cellular macromolecule biosynthetic process|chondroitin sulfate metabolic process|glycoprotein metabolic process|carbohydrate derivative biosynthetic process|sulfotransferase activity|Golgi membrane|racemase and epimerase activity, acting on carbohydrates and derivatives|dermatan sulfate metabolic process|macromolecule biosynthetic process|glycoprotein biosynthetic process|dermatan sulfate biosynthetic process|chondroitin-glucuronate 5-epimerase activity|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|carboxylic acid metabolic process|glycosaminoglycan metabolic process|dermatan sulfate proteoglycan metabolic process|monocarboxylic acid metabolic process|proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process - - - - 18:67506582-67516980 166 224 253 92 65 52 1.2320114927066 1.51089661795316 1.69294022567089 0.61177694734998 0.39581181357809 0.361691518218839 1.47861611211022 0.456426759715636 1.6957922566439 3.89114486084125e-09 7.73410377333919e-08 UP ENSG00000084463 WBP11 WW domain binding protein 11 [Source:HGNC Symbol;Acc:HGNC:16461] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0030234|GO:0005622|GO:1903829|GO:0005515|GO:0019222|GO:0060341|GO:0010506|GO:0006725|GO:0006810|GO:0051130|GO:1901360|GO:0009991|GO:0019208|GO:0003676|GO:0034641|GO:0046483|GO:0051128|GO:0033554|GO:0043231|GO:0005737|GO:0030529|GO:0032880|GO:0051222|GO:0045184|GO:0019904|GO:0032388|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0000422|GO:0051649|GO:0090316|GO:0016236|GO:0050790|GO:0022613|GO:0031323|GO:0006996|GO:0003677|GO:1903008|GO:0003723|GO:0072594|GO:0007005|GO:0032386|GO:0051223|GO:1903955|GO:0015031|GO:1903146|GO:0042254|GO:0050699|GO:0070201|GO:0046907|GO:0016241|GO:0031981|GO:0005681|GO:0005654|GO:0034613|GO:0033043|GO:0010467|GO:0019888|GO:0006626|GO:1903827|GO:0016070|GO:0031667|GO:0005634|GO:0010638|GO:0006364|GO:0033365|GO:0033157|GO:0006396|GO:0003697|GO:0006839|GO:0034660|GO:0006605|GO:0072655|GO:0010822|GO:0016604|GO:0016482|GO:0006886|GO:0010821|GO:0016071|GO:0044822|GO:0008599|GO:1903214|GO:0016607|GO:1903533|GO:0006397|GO:0016072|GO:0008380|GO:0070585|GO:0000375|GO:0000398|GO:0045292 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|enzyme regulator activity|intracellular|positive regulation of cellular protein localization|protein binding|regulation of metabolic process|regulation of cellular localization|regulation of autophagy|cellular aromatic compound metabolic process|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|response to extracellular stimulus|phosphatase regulator activity|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|protein domain specific binding|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|mitophagy|establishment of localization in cell|positive regulation of intracellular protein transport|macroautophagy|regulation of catalytic activity|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|organelle organization|DNA binding|organelle disassembly|RNA binding|establishment of protein localization to organelle|mitochondrion organization|regulation of intracellular transport|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|regulation of mitophagy|ribosome biogenesis|WW domain binding|regulation of establishment of protein localization|intracellular transport|regulation of macroautophagy|nuclear lumen|spliceosomal complex|nucleoplasm|cellular protein localization|regulation of organelle organization|gene expression|protein phosphatase regulator activity|protein targeting to mitochondrion|regulation of cellular protein localization|RNA metabolic process|response to nutrient levels|nucleus|positive regulation of organelle organization|rRNA processing|protein localization to organelle|regulation of intracellular protein transport|RNA processing|single-stranded DNA binding|mitochondrial transport|ncRNA metabolic process|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|nuclear body|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|mRNA metabolic process|poly(A) RNA binding|protein phosphatase type 1 regulator activity|regulation of protein targeting to mitochondrion|nuclear speck|regulation of protein targeting|mRNA processing|rRNA metabolic process|RNA splicing|protein localization to mitochondrion|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|mRNA cis splicing, via spliceosome K12866 WW domain-binding protein 11[-] hsa03040 Spliceosome - Homo sapiens (human) 12:14784579-14803540 4887 5008 3667 1933 2292 1381 58.5718384289716 54.5495145301915 39.6252133509965 20.757548706258 22.5387146273449 15.5120482204243 50.9155221033865 19.6027705180091 1.37704797414777 3.89833083515242e-09 7.74298503912641e-08 UP ENSG00000177363 LRRN4CL LRRN4 C-terminal like [Source:HGNC Symbol;Acc:HGNC:33724] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 11:62686402-62689899 46 52 18 3 6 2 1.25875296615605 1.29320685033331 0.444102489725665 0.0735437132357762 0.134702128224106 0.0512849093831475 0.998687435405008 0.0865102502810099 3.52909023299771 3.90080039487041e-09 7.74298503912641e-08 UP ENSG00000112640 PPP2R5D protein phosphatase 2 regulatory subunit B', delta [Source:HGNC Symbol;Acc:HGNC:9312] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0043227|GO:0016787|GO:0008287|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0002757|GO:0045087|GO:0006725|GO:1901360|GO:0006082|GO:0007275|GO:0019208|GO:0034641|GO:0015980|GO:0016788|GO:0044281|GO:0006952|GO:0019637|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0002218|GO:0005975|GO:0051186|GO:0000159|GO:0006139|GO:0050776|GO:0055086|GO:0007154|GO:0007165|GO:0050778|GO:0050790|GO:0006091|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0055114|GO:0000165|GO:0032268|GO:0005829|GO:0007166|GO:0043412|GO:0002758|GO:0019693|GO:0036211|GO:0009116|GO:0031981|GO:0031098|GO:0005996|GO:0070848|GO:0005654|GO:0016052|GO:0002764|GO:0006112|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0007399|GO:0071310|GO:0019888|GO:0051246|GO:0005634|GO:0042578|GO:0045089|GO:0045088|GO:0006757|GO:0019318|GO:0016311|GO:0009259|GO:0009117|GO:0008601|GO:0071363|GO:0016310|GO:0038179|GO:0002221|GO:0007167|GO:0009132|GO:0061621|GO:0006163|GO:0016791|GO:0019752|GO:0006096|GO:0006464|GO:0051403|GO:0042278|GO:0010921|GO:0048011|GO:0006470|GO:0035304|GO:0046939|GO:0002224|GO:0006468|GO:0006006|GO:0043666|GO:0004721|GO:0061615|GO:0032787|GO:0006165|GO:0035303|GO:0007169|GO:0006007|GO:0034047|GO:0046034|GO:0004722|GO:0034166|GO:0034134|GO:0019674|GO:0038124|GO:0002756|GO:0046031|GO:0034138|GO:0002755|GO:0034146|GO:0034142|GO:0006090|GO:0038123|GO:0034162|GO:0006734|GO:0035666 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|membrane-bounded organelle|hydrolase activity|protein serine/threonine phosphatase complex|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|anatomical structure development|regulation of metabolic process|immune response-activating signal transduction|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|phosphatase regulator activity|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|hydrolase activity, acting on ester bonds|small molecule metabolic process|defense response|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|activation of innate immune response|carbohydrate metabolic process|cofactor metabolic process|protein phosphatase type 2A complex|nucleobase-containing compound metabolic process|regulation of immune response|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|positive regulation of immune response|regulation of catalytic activity|generation of precursor metabolites and energy|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|oxidation-reduction process|MAPK cascade|regulation of cellular protein metabolic process|cytosol|cell surface receptor signaling pathway|macromolecule modification|innate immune response-activating signal transduction|ribose phosphate metabolic process|protein modification process|nucleoside metabolic process|nuclear lumen|stress-activated protein kinase signaling cascade|monosaccharide metabolic process|response to growth factor|nucleoplasm|carbohydrate catabolic process|immune response-regulating signaling pathway|energy reserve metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|cellular response to organic substance|protein phosphatase regulator activity|regulation of protein metabolic process|nucleus|phosphoric ester hydrolase activity|positive regulation of innate immune response|regulation of innate immune response|ATP generation from ADP|hexose metabolic process|dephosphorylation|ribonucleotide metabolic process|nucleotide metabolic process|protein phosphatase type 2A regulator activity|cellular response to growth factor stimulus|phosphorylation|neurotrophin signaling pathway|pattern recognition receptor signaling pathway|enzyme linked receptor protein signaling pathway|nucleoside diphosphate metabolic process|canonical glycolysis|purine nucleotide metabolic process|phosphatase activity|carboxylic acid metabolic process|glycolytic process|cellular protein modification process|stress-activated MAPK cascade|purine nucleoside metabolic process|regulation of phosphatase activity|neurotrophin TRK receptor signaling pathway|protein dephosphorylation|regulation of protein dephosphorylation|nucleotide phosphorylation|toll-like receptor signaling pathway|protein phosphorylation|glucose metabolic process|regulation of phosphoprotein phosphatase activity|phosphoprotein phosphatase activity|glycolytic process through fructose-6-phosphate|monocarboxylic acid metabolic process|nucleoside diphosphate phosphorylation|regulation of dephosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|glucose catabolic process|regulation of protein phosphatase type 2A activity|ATP metabolic process|protein serine/threonine phosphatase activity|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|NAD metabolic process|toll-like receptor TLR6:TLR2 signaling pathway|MyD88-independent toll-like receptor signaling pathway|ADP metabolic process|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|pyruvate metabolic process|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|NADH metabolic process|TRIF-dependent toll-like receptor signaling pathway K11584 serine/threonine-protein phosphatase 2A regulatory subunit B'[-] hsa04151|hsa04261|hsa04728|hsa04152|hsa04114|hsa04071|hsa03015 PI3K-Akt signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human) 6:42984499-43012342 2514 2727 2649 1279 1511 1107 27.1499938733281 26.7651428614088 25.7929294232251 12.3757840397145 13.388656470504 11.2042073018987 26.5693553859873 12.3228826040391 1.10842345134811 3.94171030096743e-09 7.81899131728117e-08 UP ENSG00000151575 TEX9 testis expressed 9 [Source:HGNC Symbol;Acc:HGNC:29585] - - - - - - 15:56244009-56445997 16 17 25 70 87 118 0.0976618576339234 0.0943062007077445 0.137580285248164 0.382822628876895 0.435696970280369 0.675011233849026 0.109849447863277 0.497843611002097 -2.18016499730011 3.98215509504958e-09 7.8939746485797e-08 DOWN ENSG00000140259 MFAP1 microfibrillar associated protein 1 [Source:HGNC Symbol;Acc:HGNC:7032] GO:0031012|GO:0009987|GO:0005576|GO:0005488|GO:0043205|GO:0097159|GO:0005578|GO:0016043|GO:0005515|GO:0003676|GO:0043062|GO:0001527|GO:0003723|GO:0030198|GO:0044822 extracellular matrix|cellular process|extracellular region|binding|fibril|organic cyclic compound binding|proteinaceous extracellular matrix|cellular component organization|protein binding|nucleic acid binding|extracellular structure organization|microfibril|RNA binding|extracellular matrix organization|poly(A) RNA binding - - - - 15:43804492-43824802 1692 1692 1338 712 805 614 41.2144471170808 37.4566931186009 29.3845836349619 15.5391281745789 16.0884056808967 14.0167096652713 36.0185746235479 15.214747840249 1.24327066634439 4.09517234990093e-09 8.11262610046067e-08 UP ENSG00000064651 SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:10911] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0022857|GO:0045177|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0006810|GO:0016324|GO:0031982|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0070062|GO:0016021|GO:0006811|GO:0015075|GO:0034220|GO:0070633|GO:0030321|GO:0098655|GO:0006820|GO:0098656|GO:0015293|GO:0008509|GO:0006812|GO:0015696|GO:0070634|GO:0008324|GO:0072488|GO:0022890|GO:0030001|GO:0015698|GO:0015672|GO:0015377|GO:0006813|GO:1902476|GO:0006814|GO:0006821|GO:0008511|GO:0015108|GO:0015077|GO:0008519 transporter activity|cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|transmembrane transporter activity|apical part of cell|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|transport|apical plasma membrane|vesicle|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|extracellular exosome|integral component of membrane|ion transport|ion transmembrane transporter activity|ion transmembrane transport|transepithelial transport|transepithelial chloride transport|cation transmembrane transport|anion transport|anion transmembrane transport|symporter activity|anion transmembrane transporter activity|cation transport|ammonium transport|transepithelial ammonium transport|cation transmembrane transporter activity|ammonium transmembrane transport|inorganic cation transmembrane transporter activity|metal ion transport|inorganic anion transport|monovalent inorganic cation transport|cation:chloride symporter activity|potassium ion transport|chloride transmembrane transport|sodium ion transport|chloride transport|sodium:potassium:chloride symporter activity|chloride transmembrane transporter activity|monovalent inorganic cation transmembrane transporter activity|ammonium transmembrane transporter activity K10951 solute carrier family 12 (sodium/potassium/chloride transporter), member 2[-] hsa04972|hsa04970|hsa05110 Pancreatic secretion - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Vibrio cholerae infection - Homo sapiens (human) 5:128083766-128189688 328 454 448 966 1059 1022 1.47302830437309 1.85299320634965 1.81396946623304 3.88698189546168 3.90212663039596 4.30147700481408 1.71333032565193 4.03019517689057 -1.23404638210274 4.12078229908903e-09 8.15794660192333e-08 DOWN ENSG00000211448 DIO2 deiodinase, iodothyronine, type II [Source:HGNC Symbol;Acc:HGNC:2884] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0050794|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0042445|GO:0071944|GO:0009058|GO:0031224|GO:0008430|GO:0005515|GO:0005886|GO:0019222|GO:0006575|GO:0006725|GO:1901360|GO:0034641|GO:0044281|GO:0042403|GO:0019899|GO:0004800|GO:0042446|GO:0042447|GO:0010817|GO:0016021|GO:0044249|GO:0019538|GO:0031323|GO:0055114|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0006590|GO:0042404|GO:0018958|GO:0043603|GO:0044267|GO:0010467|GO:0019439|GO:0051246|GO:0009059|GO:0042219|GO:0044389|GO:0031625|GO:0043043|GO:0010608|GO:0006412|GO:0006417|GO:0006414|GO:0001514 cell|membrane|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|hormone metabolic process|cell periphery|biosynthetic process|intrinsic component of membrane|selenium binding|protein binding|plasma membrane|regulation of metabolic process|cellular modified amino acid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|thyroid hormone metabolic process|enzyme binding|thyroxine 5'-deiodinase activity|hormone biosynthetic process|hormone catabolic process|regulation of hormone levels|integral component of membrane|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|oxidation-reduction process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|thyroid hormone generation|thyroid hormone catabolic process|phenol-containing compound metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cellular modified amino acid catabolic process|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|peptide biosynthetic process|posttranscriptional regulation of gene expression|translation|regulation of translation|translational elongation|selenocysteine incorporation K17904 type II thyroxine 5'-deiodinase[1.21.99.4] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) 14:80197527-80387757 914 1134 693 3083 3015 2322 3.72127652108457 4.19603558514425 2.54385990201059 11.2464945591192 10.0716630259704 8.86006805322157 3.4870573360798 10.0594085461037 -1.52846349181547 4.17429215313407e-09 8.25840410468287e-08 DOWN ENSG00000110619 CARS cysteinyl-tRNA synthetase [Source:HGNC Symbol;Acc:HGNC:1493] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0042802|GO:0006725|GO:1901360|GO:0006082|GO:0003676|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0043169|GO:0005737|GO:0006520|GO:0046983|GO:0006139|GO:0000166|GO:0044249|GO:0019538|GO:0005829|GO:0034645|GO:0006518|GO:0046872|GO:0003723|GO:0035639|GO:0001883|GO:0032549|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0016070|GO:0016876|GO:0042803|GO:0043043|GO:0000049|GO:0043039|GO:0005524|GO:0034660|GO:0030554|GO:0006412|GO:0019752|GO:0004812|GO:0006418|GO:0006399|GO:0004817|GO:0006423 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|ligase activity|intracellular|protein binding|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|cation binding|cytoplasm|cellular amino acid metabolic process|protein dimerization activity|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|protein metabolic process|cytosol|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|ligase activity, forming aminoacyl-tRNA and related compounds|protein homodimerization activity|peptide biosynthetic process|tRNA binding|tRNA aminoacylation|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|translation|carboxylic acid metabolic process|aminoacyl-tRNA ligase activity|tRNA aminoacylation for protein translation|tRNA metabolic process|cysteine-tRNA ligase activity|cysteinyl-tRNA aminoacylation - - - - 11:3000922-3057613 409 533 588 1183 1375 1184 1.95746857883978 2.31834657867401 2.53724582873894 5.07286982168536 5.39935534293418 5.31070330664915 2.27102032875091 5.26097615708956 -1.21198989154336 4.2055370626156e-09 8.31470883889577e-08 DOWN ENSG00000196814 MVB12B multivesicular body subunit 12B [Source:HGNC Symbol;Acc:HGNC:23368] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0043227|GO:0008289|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0016032|GO:0006810|GO:0000813|GO:0031982|GO:0048524|GO:0043231|GO:0005737|GO:0009966|GO:0045184|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0010008|GO:0019538|GO:0050792|GO:0005768|GO:0005829|GO:0019075|GO:0007166|GO:0030163|GO:0005769|GO:0015031|GO:0044265|GO:0005770|GO:1901184|GO:0006508|GO:0044267|GO:0019058|GO:0031902|GO:0005634|GO:0044257|GO:0042058|GO:0051603|GO:0007167|GO:0019941|GO:0007169|GO:0006511|GO:0038127|GO:0007173|GO:0043162 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|lipid binding|cell periphery|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|viral process|transport|ESCRT I complex|vesicle|positive regulation of viral process|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|establishment of protein localization|regulation of cell communication|protein localization|cell communication|signal transduction|extracellular exosome|endosome membrane|protein metabolic process|regulation of viral process|endosome|cytosol|virus maturation|cell surface receptor signaling pathway|protein catabolic process|early endosome|protein transport|cellular macromolecule catabolic process|late endosome|regulation of ERBB signaling pathway|proteolysis|cellular protein metabolic process|viral life cycle|late endosome membrane|nucleus|cellular protein catabolic process|regulation of epidermal growth factor receptor signaling pathway|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|modification-dependent protein catabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|ubiquitin-dependent protein catabolic process|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway K12186 ESCRT-I complex subunit MVB12[-] hsa04144 Endocytosis - Homo sapiens (human) 9:126326849-126507041 59 63 56 185 223 193 0.488808370381118 0.47436524427726 0.418306882579318 1.37327722697191 1.51587258161314 1.49856766727089 0.460493499079232 1.46257249195198 -1.66725543857331 4.21850246342263e-09 8.33482280231762e-08 DOWN ENSG00000115602 IL1RL1 interleukin 1 receptor-like 1 [Source:HGNC Symbol;Acc:HGNC:5998] GO:0031012|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0005578|GO:0051050|GO:0006950|GO:0005057|GO:0006955|GO:0009986|GO:0051641|GO:0038023|GO:0023051|GO:0071944|GO:0009605|GO:0023057|GO:0031224|GO:0005615|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0060341|GO:0001818|GO:0042127|GO:0002250|GO:0009897|GO:0050867|GO:0006810|GO:0032940|GO:0006952|GO:0001817|GO:0010243|GO:0004888|GO:0001816|GO:0009611|GO:0032880|GO:0051222|GO:0002696|GO:0001775|GO:0009966|GO:0045184|GO:0001819|GO:0010646|GO:0050776|GO:0008104|GO:0050865|GO:0007154|GO:0007165|GO:0009968|GO:0019955|GO:0050777|GO:0008285|GO:0051047|GO:0016021|GO:0010033|GO:0007166|GO:0004896|GO:0034097|GO:0050727|GO:0032642|GO:0051223|GO:0015031|GO:1901652|GO:0071417|GO:0070201|GO:0006954|GO:0050714|GO:0032602|GO:0050715|GO:0051046|GO:0032634|GO:0009306|GO:0050729|GO:0002113|GO:0002820|GO:0042116|GO:0032674|GO:0002460|GO:0050663|GO:0032689|GO:0035556|GO:0043030|GO:0032609|GO:0043032|GO:0046903|GO:0071310|GO:1902532|GO:0002819|GO:0032754|GO:0050707|GO:1902531|GO:0032722|GO:0032649|GO:0090197|GO:0043124|GO:0019221|GO:0043122|GO:0002114|GO:1901653|GO:0050708|GO:0004908|GO:0090195|GO:0007249|GO:0071345|GO:0042088|GO:0038172|GO:0002826 extracellular matrix|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|proteinaceous extracellular matrix|positive regulation of transport|response to stress|receptor signaling protein activity|immune response|cell surface|cellular localization|signaling receptor activity|regulation of signaling|cell periphery|response to external stimulus|negative regulation of signaling|intrinsic component of membrane|extracellular space|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|regulation of cellular localization|negative regulation of cytokine production|regulation of cell proliferation|adaptive immune response|external side of plasma membrane|positive regulation of cell activation|transport|secretion by cell|defense response|regulation of cytokine production|response to organonitrogen compound|transmembrane signaling receptor activity|cytokine production|response to wounding|regulation of protein localization|positive regulation of protein transport|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|establishment of protein localization|positive regulation of cytokine production|regulation of cell communication|regulation of immune response|protein localization|regulation of cell activation|cell communication|signal transduction|negative regulation of signal transduction|cytokine binding|negative regulation of immune response|negative regulation of cell proliferation|positive regulation of secretion|integral component of membrane|response to organic substance|cell surface receptor signaling pathway|cytokine receptor activity|response to cytokine|regulation of inflammatory response|regulation of chemokine production|regulation of protein transport|protein transport|response to peptide|cellular response to organonitrogen compound|regulation of establishment of protein localization|inflammatory response|positive regulation of protein secretion|chemokine production|positive regulation of cytokine secretion|regulation of secretion|interleukin-5 production|protein secretion|positive regulation of inflammatory response|interleukin-33 binding|negative regulation of adaptive immune response|macrophage activation|regulation of interleukin-5 production|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|cytokine secretion|negative regulation of interferon-gamma production|intracellular signal transduction|regulation of macrophage activation|interferon-gamma production|positive regulation of macrophage activation|secretion|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of adaptive immune response|positive regulation of interleukin-5 production|regulation of cytokine secretion|regulation of intracellular signal transduction|positive regulation of chemokine production|regulation of interferon-gamma production|positive regulation of chemokine secretion|negative regulation of I-kappaB kinase/NF-kappaB signaling|cytokine-mediated signaling pathway|regulation of I-kappaB kinase/NF-kappaB signaling|interleukin-33 receptor activity|cellular response to peptide|regulation of protein secretion|interleukin-1 receptor activity|chemokine secretion|I-kappaB kinase/NF-kappaB signaling|cellular response to cytokine stimulus|T-helper 1 type immune response|interleukin-33-mediated signaling pathway|negative regulation of T-helper 1 type immune response - - - - 2:102311502-102352037 451 460 790 242 201 119 2.64376628498986 2.4506687499534 4.17529842631382 1.27104113575517 0.96674005031057 0.653765719271905 3.08991115375236 0.963848968445882 1.68068635164435 4.23752942641999e-09 8.36687853811788e-08 UP ENSG00000215883 CYB5RL cytochrome b5 reductase-like [Source:HGNC Symbol;Acc:HGNC:32220] GO:0005623|GO:0008152|GO:0003824|GO:0016491|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0016651|GO:0055114|GO:0016653|GO:0031981|GO:0005654|GO:0005634|GO:0004128 cell|metabolic process|catalytic activity|oxidoreductase activity|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|oxidoreductase activity, acting on NAD(P)H|oxidation-reduction process|oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor|nuclear lumen|nucleoplasm|nucleus|cytochrome-b5 reductase activity, acting on NAD(P)H K00326 cytochrome-b5 reductase[1.6.2.2] hsa00520 Amino sugar and nucleotide sugar metabolism - Homo sapiens (human) 1:54172336-54200036 25 24 60 158 161 152 0.13936783553688 0.121593131838417 0.301569577701085 0.789175988716184 0.736399185751781 0.794128977769752 0.187510181692127 0.773234717412572 -2.04393747924497 4.24371877802001e-09 8.37356116318634e-08 DOWN ENSG00000234771 SLC25A25-AS1 SLC25A25 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:27844] - - - - - - 9:128108581-128118693 231 213 159 39 69 68 2.55675403566554 2.14257952863397 1.58668074608659 0.386755918377169 0.626602888883167 0.705366111670794 2.09533810346203 0.572908306310377 1.87080689583085 4.25324780001955e-09 8.38682033168981e-08 UP ENSG00000118939 UCHL3 ubiquitin C-terminal hydrolase L3 [Source:HGNC Symbol;Acc:HGNC:12515] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0032182|GO:0031982|GO:0043231|GO:0008233|GO:0005737|GO:0070062|GO:0019538|GO:0036459|GO:0043412|GO:0030163|GO:0043130|GO:0044265|GO:0036211|GO:0006508|GO:0044267|GO:0005634|GO:0044257|GO:0051603|GO:0070646|GO:0004843|GO:0008234|GO:0006464|GO:0019941|GO:0016579|GO:0006511 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|ubiquitin-like protein binding|vesicle|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|extracellular exosome|protein metabolic process|thiol-dependent ubiquitinyl hydrolase activity|macromolecule modification|protein catabolic process|ubiquitin binding|cellular macromolecule catabolic process|protein modification process|proteolysis|cellular protein metabolic process|nucleus|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|protein modification by small protein removal|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|modification-dependent protein catabolic process|protein deubiquitination|ubiquitin-dependent protein catabolic process - - - - 13:75549480-75606020 321 360 394 1039 1184 721 7.64528644817135 7.79240025200842 8.46056734113392 22.171883427672 23.1370913974978 16.0936081956629 7.9660846804379 20.4675276736109 -1.36139412504692 4.27500633863617e-09 8.42416100552107e-08 DOWN ENSG00000100347 SAMM50 SAMM50 sorting and assembly machinery component [Source:HGNC Symbol;Acc:HGNC:24276] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0019867|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0019866|GO:0006810|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0031966|GO:0045184|GO:0008104|GO:0055085|GO:0061024|GO:0070062|GO:0051649|GO:0016021|GO:0019538|GO:0006996|GO:0005740|GO:0090150|GO:0072594|GO:0007005|GO:0005741|GO:0015031|GO:0045040|GO:0046907|GO:0005743|GO:0072657|GO:0001401|GO:0005739|GO:0006461|GO:0034613|GO:0044267|GO:0017038|GO:0006626|GO:0071806|GO:0007006|GO:0033365|GO:0034622|GO:0007008|GO:0006839|GO:0043623|GO:0006605|GO:0072655|GO:0007007|GO:0006886|GO:0065002|GO:0033108|GO:0042407|GO:0070585 macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|outer membrane|intrinsic component of membrane|intracellular|protein binding|protein complex|organelle membrane|organelle inner membrane|transport|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|establishment of protein localization|protein localization|transmembrane transport|membrane organization|extracellular exosome|establishment of localization in cell|integral component of membrane|protein metabolic process|organelle organization|mitochondrial envelope|establishment of protein localization to membrane|establishment of protein localization to organelle|mitochondrion organization|mitochondrial outer membrane|protein transport|protein import into mitochondrial outer membrane|intracellular transport|mitochondrial inner membrane|protein localization to membrane|mitochondrial sorting and assembly machinery complex|mitochondrion|protein complex assembly|cellular protein localization|cellular protein metabolic process|protein import|protein targeting to mitochondrion|protein transmembrane transport|mitochondrial membrane organization|protein localization to organelle|cellular macromolecular complex assembly|outer mitochondrial membrane organization|mitochondrial transport|cellular protein complex assembly|protein targeting|establishment of protein localization to mitochondrion|inner mitochondrial membrane organization|intracellular protein transport|intracellular protein transmembrane transport|mitochondrial respiratory chain complex assembly|cristae formation|protein localization to mitochondrion - - - - 22:43955421-44010531 541 609 791 1574 1699 1510 5.26753110393711 5.38898794092377 6.94385926173469 13.7313321205962 13.5728590112934 13.7789439094186 5.86679276886519 13.6943783471027 -1.22293983865231 4.28534845274539e-09 8.43897049526786e-08 DOWN ENSG00000273760 CH17-360D5.3 - - - - - - - 10:47970043-47973496 59 70 53 282 329 162 5.05259790110652 5.44807644737877 4.09217510084166 21.6378006915484 23.1168869778492 13.0019740550218 4.86428314977565 19.2522205748065 -1.98472574205239 4.29371038529967e-09 8.44986353610654e-08 DOWN ENSG00000170113 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 [Source:HGNC Symbol;Acc:HGNC:17043] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0006810|GO:0043231|GO:0005737|GO:0022891|GO:0055085|GO:0016021|GO:0005768|GO:0005769|GO:0006811|GO:0015075|GO:1903830|GO:0006812|GO:0008324|GO:0022890|GO:0030001|GO:0046873|GO:0015095|GO:0015693 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|transport|intracellular membrane-bounded organelle|cytoplasm|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|endosome|early endosome|ion transport|ion transmembrane transporter activity|magnesium ion transmembrane transport|cation transport|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|metal ion transmembrane transporter activity|magnesium ion transmembrane transporter activity|magnesium ion transport - - - - 15:22773063-22829791 1365 1415 1630 587 693 819 5.18698823735138 4.88673777683894 5.58450469086723 1.99856621945082 2.16064670602338 2.91672659624712 5.21941023501918 2.35864650724044 1.14592758270836 4.34997093084727e-09 8.55494283066631e-08 UP ENSG00000268606 MAGEA2 MAGE family member A2 [Source:HGNC Symbol;Acc:HGNC:6800] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0009890|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0008134|GO:0050790|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0007568|GO:0032268|GO:0010468|GO:0034645|GO:0043412|GO:0030163|GO:0010629|GO:0051252|GO:0070491|GO:0044265|GO:0051347|GO:0036211|GO:0032269|GO:0007569|GO:0031981|GO:0051351|GO:0042826|GO:0051247|GO:0005654|GO:0032270|GO:0035556|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0090398|GO:0044389|GO:0031625|GO:0044257|GO:0031401|GO:0045892|GO:0072331|GO:0032774|GO:2001141|GO:1902679|GO:0016604|GO:0051438|GO:0051443|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:1901984|GO:0018193|GO:0016605|GO:0000122|GO:0032446|GO:0031398|GO:0033234|GO:0031396|GO:0033233|GO:0006473|GO:0018205|GO:0016925|GO:0016567 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|transcription factor binding|regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|aging|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|protein catabolic process|negative regulation of gene expression|regulation of RNA metabolic process|repressing transcription factor binding|cellular macromolecule catabolic process|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|cell aging|nuclear lumen|positive regulation of ligase activity|histone deacetylase binding|positive regulation of protein metabolic process|nucleoplasm|positive regulation of cellular protein metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular senescence|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|positive regulation of protein modification process|negative regulation of transcription, DNA-templated|signal transduction by p53 class mediator|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|nuclear body|regulation of ubiquitin-protein transferase activity|positive regulation of ubiquitin-protein transferase activity|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of protein acetylation|peptidyl-amino acid modification|PML body|negative regulation of transcription from RNA polymerase II promoter|protein modification by small protein conjugation|positive regulation of protein ubiquitination|negative regulation of protein sumoylation|regulation of protein ubiquitination|regulation of protein sumoylation|protein acetylation|peptidyl-lysine modification|protein sumoylation|protein ubiquitination - - - - X:152749863-152753884 757 705 457 201 290 165 8.66469125199751 7.33375054860871 4.71614921625082 2.06134864168212 2.72347424447339 1.76998184556329 6.90486367228568 2.18493491057293 1.66002262825547 4.36539611986119e-09 8.57962710746122e-08 UP ENSG00000065882 TBC1D1 TBC1 domain family member 1 [Source:HGNC Symbol;Acc:HGNC:11578] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0016043|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0008047|GO:0043231|GO:0005737|GO:0032880|GO:0043085|GO:0008104|GO:0061024|GO:0050790|GO:0005829|GO:0005096|GO:0051345|GO:0030695|GO:0005634|GO:0043087|GO:0043547 cell|cellular process|metabolic process|binding|intracellular organelle|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|enzyme activator activity|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|positive regulation of catalytic activity|protein localization|membrane organization|regulation of catalytic activity|cytosol|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|nucleus|regulation of GTPase activity|positive regulation of GTPase activity K18341 TBC1 domain family member 1[-] hsa04152 AMPK signaling pathway - Homo sapiens (human) 4:37891087-38139175 300 381 712 1266 1401 1853 1.35131576659978 1.55969768955574 2.89154174422394 5.10936490291307 5.17775576610558 7.82239743716567 1.93418506679315 6.03650603539477 -1.64198790944791 4.45381722271495e-09 8.74764864256133e-08 DOWN ENSG00000171492 LRRC8D leucine-rich repeat containing 8 family member D [Source:HGNC Symbol;Acc:HGNC:16992] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0042175|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0005783|GO:0016021|GO:0006811 cell|membrane|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane|ion transport - - - - 1:89821014-89936611 226 212 398 839 911 690 1.53820014401262 1.31135456949512 2.44231667575816 5.11640258696267 5.08734327328147 4.40131590180006 1.7639571297553 4.8683539206814 -1.46461855437664 4.49279801381995e-09 8.81840840924265e-08 DOWN ENSG00000099821 POLRMT polymerase (RNA) mitochondrial (DNA directed) [Source:HGNC Symbol;Acc:HGNC:9200] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0042645|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016772|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0006996|GO:0003677|GO:0034645|GO:0003723|GO:0007005|GO:0006390|GO:0005759|GO:0005739|GO:0010467|GO:0009059|GO:0016779|GO:0016070|GO:0032774|GO:0044822|GO:0006391|GO:0006351|GO:0006352|GO:0003899 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|mitochondrial nucleoid|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|organelle organization|DNA binding|cellular macromolecule biosynthetic process|RNA binding|mitochondrion organization|transcription from mitochondrial promoter|mitochondrial matrix|mitochondrion|gene expression|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|RNA biosynthetic process|poly(A) RNA binding|transcription initiation from mitochondrial promoter|transcription, DNA-templated|DNA-templated transcription, initiation|DNA-directed RNA polymerase activity - - - - 19:617224-633604 2935 3221 2746 1390 1627 1341 26.1806618185283 26.1121908976802 22.0844882591325 11.1092604900058 11.9077011466318 11.2106338206915 24.7924469917803 11.4091984857764 1.11970322754955 4.49845408936641e-09 8.82370882943132e-08 UP ENSG00000131115 ZNF227 zinc finger protein 227 [Source:HGNC Symbol;Acc:HGNC:13020] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:44207547-44237268 597 608 520 180 61 185 4.24890751363789 3.93266329745346 3.3367259593211 1.14781856926833 0.356207438129916 1.23396863501224 3.83943225680415 0.912664880803495 2.07273587014271 4.5176696960946e-09 8.85558181925201e-08 UP ENSG00000234608 MAPKAPK5-AS1 MAPKAPK5 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:24091] - - - - - - 12:111839764-111842902 365 435 413 140 210 159 4.62871572313282 5.01344690373845 4.72205712028118 1.59071329757917 2.18501053244193 1.88970479263442 4.78807324905082 1.88847620755184 1.34222261540039 4.53539498298516e-09 8.88449355787658e-08 UP ENSG00000174292 TNK1 tyrosine kinase, non-receptor, 1 [Source:HGNC Symbol;Acc:HGNC:11940] GO:0032502|GO:0040007|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0016049|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0045926|GO:0016043|GO:0071944|GO:0040008|GO:0023057|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0042127|GO:0009898|GO:0045087|GO:0005102|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0051128|GO:0030308|GO:0005737|GO:0031234|GO:0098562|GO:0009966|GO:0019897|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0000166|GO:0048869|GO:0019538|GO:0001558|GO:0005829|GO:0007166|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:1902532|GO:0017076|GO:0030154|GO:1902531|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0007167|GO:0004672|GO:0051056|GO:0007264|GO:0006464|GO:0051058|GO:0007265|GO:0046578|GO:0006468|GO:0004713|GO:0018193|GO:0046580|GO:0007169|GO:0004715|GO:0046777|GO:0018108|GO:0038083 developmental process|growth|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|cell growth|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|negative regulation of growth|cellular component organization|cell periphery|regulation of growth|negative regulation of signaling|intracellular|protein binding|plasma membrane|transferase activity|regulation of cell proliferation|cytoplasmic side of plasma membrane|innate immune response|receptor binding|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|negative regulation of cell growth|cytoplasm|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|regulation of signal transduction|extrinsic component of plasma membrane|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|nucleotide binding|cellular developmental process|protein metabolic process|regulation of cell growth|cytosol|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|negative regulation of intracellular signal transduction|purine nucleotide binding|cell differentiation|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|enzyme linked receptor protein signaling pathway|protein kinase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|Ras protein signal transduction|regulation of Ras protein signal transduction|protein phosphorylation|protein tyrosine kinase activity|peptidyl-amino acid modification|negative regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|non-membrane spanning protein tyrosine kinase activity|protein autophosphorylation|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation - - - - 17:7380534-7389774 762 778 468 222 290 233 7.87457894558947 7.30687828587754 4.36045688155107 2.05552964955924 2.4588854391301 2.25661842834471 6.51397137100603 2.25701117234468 1.52912381910619 4.54234291897633e-09 8.8922692133193e-08 UP ENSG00000104129 DNAJC17 DnaJ heat shock protein family (Hsp40) member C17 [Source:HGNC Symbol;Acc:HGNC:25556] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0009890|GO:0006139|GO:0000166|GO:0044249|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:1901998|GO:0003723|GO:0010629|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|toxin transport|RNA binding|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 15:40765155-40807478 47 40 54 159 167 158 0.445185204999465 0.344334772785589 0.461160693555007 1.34938442880563 1.29785408000317 1.40258269790266 0.416893557113354 1.34994040223715 -1.69514473466375 4.61209512094681e-09 9.02290221105806e-08 DOWN ENSG00000154832 CXXC1 CXXC finger protein 1 [Source:HGNC Symbol;Acc:HGNC:24343] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0030968|GO:0043412|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0010628|GO:0036211|GO:0006986|GO:0031981|GO:1990234|GO:0005654|GO:0016363|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0034399|GO:0035097|GO:0035967|GO:0016070|GO:0034976|GO:0010557|GO:0005634|GO:0034620|GO:0000975|GO:0045893|GO:0048188|GO:0036498|GO:0032774|GO:0043565|GO:2001141|GO:0016604|GO:0003690|GO:0018022|GO:0008276|GO:0034968|GO:0046914|GO:0016568|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0016607|GO:0016279|GO:0051568|GO:1903506|GO:0044212|GO:0018193|GO:0042054|GO:0045322|GO:0008270|GO:0018024|GO:0000976|GO:0001159|GO:0018205|GO:0042800|GO:0000987 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|methylation|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|endoplasmic reticulum unfolded protein response|macromolecule modification|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|positive regulation of gene expression|protein modification process|response to unfolded protein|nuclear lumen|transferase complex|nucleoplasm|nuclear matrix|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|nuclear periphery|histone methyltransferase complex|cellular response to topologically incorrect protein|RNA metabolic process|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to unfolded protein|regulatory region DNA binding|positive regulation of transcription, DNA-templated|Set1C/COMPASS complex|IRE1-mediated unfolded protein response|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nuclear body|double-stranded DNA binding|peptidyl-lysine methylation|protein methyltransferase activity|histone lysine methylation|transition metal ion binding|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|nuclear speck|protein-lysine N-methyltransferase activity|histone H3-K4 methylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|peptidyl-amino acid modification|histone methyltransferase activity|unmethylated CpG binding|zinc ion binding|histone-lysine N-methyltransferase activity|transcription regulatory region sequence-specific DNA binding|core promoter proximal region DNA binding|peptidyl-lysine modification|histone methyltransferase activity (H3-K4 specific)|core promoter proximal region sequence-specific DNA binding - - - - 18:50282343-50288304 1089 1047 901 495 518 391 7.09976601587711 6.20358493555386 5.2960850701456 2.89147134468981 2.77085629750069 2.3890295127379 6.19981200719219 2.68378571830947 1.20795498333767 4.64887624709535e-09 9.08890317490402e-08 UP ENSG00000261488 RP11-757F18.5 - - - - - - - 3:112133423-112135359 5 11 22 57 81 91 0.182602449775567 0.365095894438634 0.72434196983684 1.86505545754853 2.4269939014558 3.1144958769369 0.424013438017014 2.46884841198041 -2.54165636415966 4.66557062943014e-09 9.11557235412353e-08 DOWN ENSG00000151914 DST dystonin [Source:HGNC Symbol;Acc:HGNC:1090] GO:0040011|GO:0031012|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0005604|GO:1903561|GO:0051716|GO:0042995|GO:0045178|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0005578|GO:0006950|GO:0042175|GO:0043167|GO:0048870|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0042802|GO:0030017|GO:0030018|GO:0051726|GO:0007049|GO:0008022|GO:0045103|GO:0016323|GO:0009925|GO:0022402|GO:0005938|GO:0005102|GO:0005924|GO:0043062|GO:0005874|GO:0005912|GO:0031982|GO:0016817|GO:0022607|GO:0005882|GO:0045786|GO:0043231|GO:0043169|GO:0005737|GO:0009611|GO:0005635|GO:0006928|GO:0032403|GO:0043005|GO:0046983|GO:0031672|GO:0050839|GO:0030056|GO:0031674|GO:0007163|GO:0007154|GO:0007165|GO:0005783|GO:0070062|GO:0008092|GO:0016021|GO:0007017|GO:0031673|GO:0006996|GO:0015631|GO:0005829|GO:1990752|GO:0046872|GO:0007166|GO:0030424|GO:0007010|GO:0031410|GO:0003779|GO:0007050|GO:0008017|GO:0016023|GO:0016818|GO:0005178|GO:0034329|GO:0043292|GO:0031988|GO:0035371|GO:0030198|GO:0030011|GO:0000226|GO:0045104|GO:0005856|GO:0005634|GO:0042803|GO:0005925|GO:0015629|GO:0016055|GO:0030016|GO:0051010|GO:0007229|GO:0005509|GO:0007044|GO:0015630|GO:0045111|GO:0016462|GO:0017111|GO:0031581|GO:0016887 locomotion|extracellular matrix|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|basement membrane|extracellular vesicle|cellular response to stimulus|cell projection|basal part of cell|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|cell motility|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|identical protein binding|sarcomere|Z disc|regulation of cell cycle|cell cycle|protein C-terminus binding|intermediate filament-based process|basolateral plasma membrane|basal plasma membrane|cell cycle process|cell cortex|receptor binding|cell-substrate adherens junction|extracellular structure organization|microtubule|adherens junction|vesicle|hydrolase activity, acting on acid anhydrides|cellular component assembly|intermediate filament|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to wounding|nuclear envelope|movement of cell or subcellular component|protein complex binding|neuron projection|protein dimerization activity|A band|cell adhesion molecule binding|hemidesmosome|I band|establishment or maintenance of cell polarity|cell communication|signal transduction|endoplasmic reticulum|extracellular exosome|cytoskeletal protein binding|integral component of membrane|microtubule-based process|H zone|organelle organization|tubulin binding|cytosol|microtubule end|metal ion binding|cell surface receptor signaling pathway|axon|cytoskeleton organization|cytoplasmic vesicle|actin binding|cell cycle arrest|microtubule binding|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|integrin binding|cell junction assembly|contractile fiber|membrane-bounded vesicle|microtubule plus-end|extracellular matrix organization|maintenance of cell polarity|microtubule cytoskeleton organization|intermediate filament cytoskeleton organization|cytoskeleton|nucleus|protein homodimerization activity|focal adhesion|actin cytoskeleton|Wnt signaling pathway|myofibril|microtubule plus-end binding|integrin-mediated signaling pathway|calcium ion binding|cell-substrate junction assembly|microtubule cytoskeleton|intermediate filament cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|hemidesmosome assembly|ATPase activity - - - - 6:56457987-56954628 933 1343 1614 3090 3514 3218 1.18991589796556 1.55664823968996 1.85589041519808 3.53094314112359 3.67709014654155 3.84635664558361 1.53415151761787 3.68479664441625 -1.26414402747779 4.69638535247502e-09 9.16977686806994e-08 DOWN ENSG00000042429 MED17 mediator complex subunit 17 [Source:HGNC Symbol;Acc:HGNC:2375] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0016592|GO:0001076|GO:0005667|GO:0006139|GO:0007154|GO:0007165|GO:0008134|GO:0009725|GO:0019787|GO:0000151|GO:0044249|GO:0019827|GO:0019538|GO:0010033|GO:0031323|GO:0003713|GO:0042809|GO:0010468|GO:0034645|GO:0033993|GO:0043412|GO:0001104|GO:0004842|GO:0051427|GO:0051252|GO:0010628|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0046966|GO:0014070|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0009755|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0043401|GO:0045893|GO:0061630|GO:0032774|GO:2001141|GO:0035257|GO:0071383|GO:0071407|GO:0030518|GO:0030374|GO:0006464|GO:0071396|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006352|GO:0006357|GO:1903506|GO:0030521|GO:0032446|GO:0006367|GO:0016567 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|mediator complex|transcription factor activity, RNA polymerase II transcription factor binding|transcription factor complex|nucleobase-containing compound metabolic process|cell communication|signal transduction|transcription factor binding|response to hormone|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|response to organic substance|regulation of cellular metabolic process|transcription coactivator activity|vitamin D receptor binding|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|macromolecule modification|RNA polymerase II transcription cofactor activity|ubiquitin-protein transferase activity|hormone receptor binding|regulation of RNA metabolic process|positive regulation of gene expression|protein modification process|nuclear lumen|transferase complex|nucleoplasm|thyroid hormone receptor binding|response to organic cyclic compound|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|ligand-dependent nuclear receptor transcription coactivator activity|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|androgen receptor signaling pathway|protein modification by small protein conjugation|transcription initiation from RNA polymerase II promoter|protein ubiquitination K15133 mediator of RNA polymerase II transcription subunit 17[-] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) 11:93784227-93814695 1088 1096 748 456 416 332 4.68108354594271 4.28556686194828 2.90157014018738 1.75784362359564 1.46851766642124 1.3387030970542 3.95607351602612 1.52168812902369 1.37839652821577 4.83270166604725e-09 9.42976964301795e-08 UP ENSG00000186111 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma [Source:HGNC Symbol;Acc:HGNC:8996] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0030055|GO:0043229|GO:0016079|GO:0071704|GO:0050900|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0031252|GO:0009058|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0044255|GO:0001931|GO:0016337|GO:0006935|GO:0051640|GO:0048468|GO:0006810|GO:0007275|GO:0043168|GO:0005924|GO:0044281|GO:0032940|GO:0005912|GO:0001882|GO:0016772|GO:0019637|GO:0022607|GO:0098609|GO:0043231|GO:0005737|GO:0007267|GO:0001726|GO:0006928|GO:0051656|GO:0001891|GO:0007154|GO:0006629|GO:0016477|GO:0051649|GO:0001505|GO:0031256|GO:0030595|GO:0000166|GO:0030030|GO:0031253|GO:0048869|GO:0030029|GO:0044249|GO:0006996|GO:0016192|GO:0006836|GO:0051650|GO:0000902|GO:0006909|GO:0005829|GO:0031175|GO:0008654|GO:0045216|GO:0046486|GO:0035639|GO:0007010|GO:0001883|GO:0048489|GO:0000904|GO:0006887|GO:0046907|GO:0032549|GO:0034329|GO:0060326|GO:0016301|GO:0030036|GO:0032587|GO:0006796|GO:0032990|GO:0008610|GO:0007399|GO:0046903|GO:0097485|GO:0017076|GO:0051648|GO:0030154|GO:0048858|GO:0030258|GO:0016773|GO:0005634|GO:0006644|GO:0005925|GO:0071621|GO:0048666|GO:0030182|GO:0007411|GO:0045055|GO:1990266|GO:0046474|GO:0034332|GO:0005524|GO:0030554|GO:0016310|GO:0030593|GO:0061564|GO:0016482|GO:0016307|GO:0036465|GO:0046834|GO:0006897|GO:0022008|GO:0048667|GO:0048812|GO:0006650|GO:0034333|GO:0046854|GO:0046488|GO:0007409|GO:0048488|GO:0048699|GO:0016308|GO:0006661|GO:0017156|GO:0006898|GO:0007268|GO:0072583 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|cell-substrate junction|intracellular organelle|synaptic vesicle exocytosis|organic substance metabolic process|leukocyte migration|ion binding|cellular metabolic process|cellular localization|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|cell leading edge|biosynthetic process|intracellular|neurotransmitter secretion|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|cellular lipid metabolic process|uropod|single organismal cell-cell adhesion|chemotaxis|organelle localization|cell development|transport|multicellular organism development|anion binding|cell-substrate adherens junction|small molecule metabolic process|secretion by cell|adherens junction|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|cellular component assembly|cell-cell adhesion|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|ruffle|movement of cell or subcellular component|establishment of organelle localization|phagocytic cup|cell communication|lipid metabolic process|cell migration|establishment of localization in cell|regulation of neurotransmitter levels|leading edge membrane|leukocyte chemotaxis|nucleotide binding|cell projection organization|cell projection membrane|cellular developmental process|actin filament-based process|cellular biosynthetic process|organelle organization|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|cell morphogenesis|phagocytosis|cytosol|neuron projection development|phospholipid biosynthetic process|cell-cell junction organization|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|cytoskeleton organization|purine nucleoside binding|synaptic vesicle transport|cell morphogenesis involved in differentiation|exocytosis|intracellular transport|ribonucleoside binding|cell junction assembly|cell chemotaxis|kinase activity|actin cytoskeleton organization|ruffle membrane|phosphate-containing compound metabolic process|cell part morphogenesis|lipid biosynthetic process|nervous system development|secretion|neuron projection guidance|purine nucleotide binding|vesicle localization|cell differentiation|cell projection morphogenesis|lipid modification|phosphotransferase activity, alcohol group as acceptor|nucleus|phospholipid metabolic process|focal adhesion|granulocyte chemotaxis|neuron development|neuron differentiation|axon guidance|regulated exocytosis|neutrophil migration|glycerophospholipid biosynthetic process|adherens junction organization|ATP binding|adenyl nucleotide binding|phosphorylation|neutrophil chemotaxis|axon development|cytosolic transport|phosphatidylinositol phosphate kinase activity|synaptic vesicle recycling|lipid phosphorylation|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|glycerophospholipid metabolic process|adherens junction assembly|phosphatidylinositol phosphorylation|phosphatidylinositol metabolic process|axonogenesis|synaptic vesicle endocytosis|generation of neurons|1-phosphatidylinositol-4-phosphate 5-kinase activity|phosphatidylinositol biosynthetic process|calcium ion regulated exocytosis|receptor-mediated endocytosis|synaptic transmission|clathrin-mediated endocytosis K00889 1-phosphatidylinositol-4-phosphate 5-kinase[2.7.1.68] hsa01100|hsa04144|hsa04810|hsa04510|hsa04072|hsa05231|hsa04070|hsa04666|hsa00562 Metabolic pathways - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 19:3630183-3700479 154 120 156 432 424 425 1.27082346962303 0.899962231624865 1.16065202030709 3.19407730648436 2.8707620495696 3.28686043199373 1.11047924051833 3.11723326268256 -1.48908369276853 4.99292445391427e-09 9.73603962424276e-08 DOWN ENSG00000184203 PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 [Source:HGNC Symbol;Acc:HGNC:9288] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0050794|GO:0071704|GO:0044237|GO:0023051|GO:0008287|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0044262|GO:0004857|GO:0000164|GO:0019208|GO:0015980|GO:0005737|GO:0005975|GO:0009966|GO:0010646|GO:0007154|GO:0044092|GO:0007165|GO:0050790|GO:0006091|GO:0043086|GO:0019538|GO:0031323|GO:0055114|GO:0032268|GO:0005976|GO:0043412|GO:0036211|GO:0005977|GO:0006112|GO:0019212|GO:0006796|GO:0044267|GO:0051174|GO:0019888|GO:0051246|GO:0016311|GO:0004864|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0004865|GO:0043666|GO:0035303 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|regulation of cellular process|organic substance metabolic process|cellular metabolic process|regulation of signaling|protein serine/threonine phosphatase complex|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|cellular carbohydrate metabolic process|enzyme inhibitor activity|protein phosphatase type 1 complex|phosphatase regulator activity|energy derivation by oxidation of organic compounds|cytoplasm|carbohydrate metabolic process|regulation of signal transduction|regulation of cell communication|cell communication|negative regulation of molecular function|signal transduction|regulation of catalytic activity|generation of precursor metabolites and energy|negative regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|oxidation-reduction process|regulation of cellular protein metabolic process|polysaccharide metabolic process|macromolecule modification|protein modification process|glycogen metabolic process|energy reserve metabolic process|phosphatase inhibitor activity|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|protein phosphatase regulator activity|regulation of protein metabolic process|dephosphorylation|protein phosphatase inhibitor activity|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|protein serine/threonine phosphatase inhibitor activity|regulation of phosphoprotein phosphatase activity|regulation of dephosphorylation - - - - 3:195514425-195543386 2985 3161 3388 1292 1610 1768 29.4080118594964 28.3025676453843 30.0939322149236 11.404638507648 13.0141309463298 16.3242250457715 29.2681705732681 13.5809981665831 1.10774305428112 5.040708403483e-09 9.82280082751838e-08 UP ENSG00000188629 ZNF177 zinc finger protein 177 [Source:HGNC Symbol;Acc:HGNC:12966] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005615|GO:0005622|GO:0072562|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|extracellular region|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|extracellular space|intracellular|blood microparticle|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 19:9363020-9382617 11 15 21 1 0 1 0.196788650203405 0.243889720749598 0.338721729325775 0.0160214449926181 0 0.0167642249311376 0.259800033426259 0.0109285566412519 4.57122683763953 5.06170252524777e-09 9.85727770311461e-08 UP ENSG00000111846 GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) [Source:HGNC Symbol;Acc:HGNC:4204] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0006486|GO:0008284|GO:0051272|GO:0042127|GO:0016337|GO:0045595|GO:0009888|GO:0048468|GO:0010718|GO:0051130|GO:0007275|GO:0048513|GO:0030155|GO:0031325|GO:0051128|GO:2000147|GO:0098609|GO:0045597|GO:0043231|GO:0005737|GO:0005975|GO:0071559|GO:0006928|GO:0042592|GO:0031589|GO:0009966|GO:0048871|GO:0010646|GO:0007162|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0016757|GO:0045785|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0005794|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0010468|GO:0034645|GO:0007166|GO:2000736|GO:0043412|GO:0010720|GO:0001894|GO:0008194|GO:0010717|GO:0000904|GO:0030334|GO:0010812|GO:0009100|GO:0036211|GO:0071560|GO:0022407|GO:0016758|GO:0060485|GO:0010810|GO:0051247|GO:0070848|GO:0070085|GO:0022604|GO:0032270|GO:0006796|GO:0034113|GO:0035556|GO:1901137|GO:0044267|GO:0051174|GO:0048864|GO:0010467|GO:0071310|GO:0000139|GO:0051246|GO:0010770|GO:0009059|GO:0030154|GO:0022409|GO:0030335|GO:1902531|GO:2000738|GO:0051896|GO:0043491|GO:0009101|GO:0048863|GO:0043413|GO:0031401|GO:0043408|GO:0010769|GO:0008375|GO:0014031|GO:0071363|GO:0016310|GO:0051897|GO:0010608|GO:0070371|GO:0007179|GO:0007167|GO:0034116|GO:0043410|GO:0006024|GO:0036438|GO:0048762|GO:0030203|GO:0006464|GO:0001837|GO:0008532|GO:0008109|GO:0006468|GO:0042325|GO:0070374|GO:0001932|GO:0001934|GO:0007178|GO:0070372|GO:0042327 locomotion|developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|protein glycosylation|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|single organismal cell-cell adhesion|regulation of cell differentiation|tissue development|cell development|positive regulation of epithelial to mesenchymal transition|positive regulation of cellular component organization|multicellular organism development|animal organ development|regulation of cell adhesion|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|response to transforming growth factor beta|movement of cell or subcellular component|homeostatic process|cell-substrate adhesion|regulation of signal transduction|multicellular organismal homeostasis|regulation of cell communication|negative regulation of cell adhesion|cell communication|regulation of cellular component movement|cell migration|signal transduction|transferase activity, transferring glycosyl groups|positive regulation of cell adhesion|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|regulation of stem cell differentiation|macromolecule modification|positive regulation of cell development|tissue homeostasis|UDP-glycosyltransferase activity|regulation of epithelial to mesenchymal transition|cell morphogenesis involved in differentiation|regulation of cell migration|negative regulation of cell-substrate adhesion|glycoprotein metabolic process|protein modification process|cellular response to transforming growth factor beta stimulus|regulation of cell-cell adhesion|transferase activity, transferring hexosyl groups|mesenchyme development|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|response to growth factor|glycosylation|regulation of cell morphogenesis|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|heterotypic cell-cell adhesion|intracellular signal transduction|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|gene expression|cellular response to organic substance|Golgi membrane|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|positive regulation of cell migration|regulation of intracellular signal transduction|positive regulation of stem cell differentiation|regulation of protein kinase B signaling|protein kinase B signaling|glycoprotein biosynthetic process|stem cell differentiation|macromolecule glycosylation|positive regulation of protein modification process|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|acetylglucosaminyltransferase activity|mesenchymal cell development|cellular response to growth factor stimulus|phosphorylation|positive regulation of protein kinase B signaling|posttranscriptional regulation of gene expression|ERK1 and ERK2 cascade|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of heterotypic cell-cell adhesion|positive regulation of MAPK cascade|glycosaminoglycan biosynthetic process|maintenance of lens transparency|mesenchymal cell differentiation|glycosaminoglycan metabolic process|cellular protein modification process|epithelial to mesenchymal transition|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|protein phosphorylation|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation K00742 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase[2.4.1.150] hsa01100|hsa00601 Metabolic pathways - Homo sapiens (human)|Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human) 6:10492223-10629368 210 262 273 632 615 822 0.729710214108348 0.827394662510007 0.855281934017954 1.96764515228504 1.75337637210343 2.67690341530055 0.80412893687877 2.13264164656301 -1.4071428142742 5.07874556677671e-09 9.88402021841929e-08 DOWN ENSG00000118564 FBXL5 F-box and leucine-rich repeat protein 5 [Source:HGNC Symbol;Acc:HGNC:13602] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0031325|GO:0043169|GO:0005737|GO:0042592|GO:0019787|GO:0000151|GO:0019538|GO:0031323|GO:0032268|GO:0045732|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0031461|GO:0048878|GO:0044265|GO:0036211|GO:1990234|GO:0051247|GO:0048471|GO:0006508|GO:0032270|GO:0044267|GO:0042176|GO:0051246|GO:0044257|GO:0019005|GO:0010498|GO:1903364|GO:0051603|GO:0046914|GO:0050801|GO:0006464|GO:0005506|GO:0019941|GO:0043161|GO:0032446|GO:0006511|GO:0031146|GO:0055065|GO:0016567|GO:0055072 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|positive regulation of metabolic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|positive regulation of cellular metabolic process|cation binding|cytoplasm|homeostatic process|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|chemical homeostasis|cellular macromolecule catabolic process|protein modification process|transferase complex|positive regulation of protein metabolic process|perinuclear region of cytoplasm|proteolysis|positive regulation of cellular protein metabolic process|cellular protein metabolic process|regulation of protein catabolic process|regulation of protein metabolic process|cellular protein catabolic process|SCF ubiquitin ligase complex|proteasomal protein catabolic process|positive regulation of cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|transition metal ion binding|ion homeostasis|cellular protein modification process|iron ion binding|modification-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|metal ion homeostasis|protein ubiquitination|iron ion homeostasis - - - - 4:15604539-15681679 158 178 244 477 567 566 1.35209690701685 1.38436242076874 1.88258458711295 3.65735214870233 3.98108739791775 4.53937291387193 1.53968130496618 4.059270820164 -1.39858883299959 5.13882360695547e-09 9.99442605615952e-08 DOWN ENSG00000101639 CEP192 centrosomal protein 192kDa [Source:HGNC Symbol;Acc:HGNC:25515] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0016043|GO:0005622|GO:0005515|GO:0019222|GO:0007049|GO:0022402|GO:0022607|GO:0019899|GO:0005737|GO:0044092|GO:0050790|GO:0043086|GO:0007017|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0031023|GO:0032268|GO:0005829|GO:0005813|GO:1903047|GO:0043412|GO:0007010|GO:0005815|GO:0044770|GO:0007098|GO:0005814|GO:0036211|GO:0032269|GO:0000278|GO:0019902|GO:0051346|GO:0007051|GO:0006461|GO:0070925|GO:0006796|GO:0044267|GO:0051174|GO:0051298|GO:0051246|GO:0000226|GO:0005856|GO:0051225|GO:0010923|GO:0016311|GO:0000086|GO:0044772|GO:0015630|GO:0051297|GO:0006464|GO:0000242|GO:0010921|GO:0006470|GO:0035304|GO:0035305|GO:0035303|GO:0035308 cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular component organization|intracellular|protein binding|regulation of metabolic process|cell cycle|cell cycle process|cellular component assembly|enzyme binding|cytoplasm|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|microtubule-based process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|microtubule organizing center organization|regulation of cellular protein metabolic process|cytosol|centrosome|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|microtubule organizing center|cell cycle phase transition|centrosome cycle|centriole|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|phosphatase binding|negative regulation of hydrolase activity|spindle organization|protein complex assembly|organelle assembly|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|centrosome duplication|regulation of protein metabolic process|microtubule cytoskeleton organization|cytoskeleton|spindle assembly|negative regulation of phosphatase activity|dephosphorylation|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|microtubule cytoskeleton|centrosome organization|cellular protein modification process|pericentriolar material|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation - - - - 18:12991362-13125052 286 342 402 850 857 842 1.40179647009838 1.52343800658549 1.77647653957466 3.7328110730233 3.44641637615609 3.86776460409704 1.56723700541951 3.68233068442548 -1.23239582301151 5.26574131229048e-09 1.02345990323646e-07 DOWN ENSG00000137804 NUSAP1 nucleolar and spindle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18538] GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0051726|GO:0007049|GO:0051640|GO:0022402|GO:0051130|GO:0003676|GO:0051302|GO:0005874|GO:0051128|GO:0043231|GO:0005737|GO:0032403|GO:0051656|GO:0045787|GO:0051649|GO:0008092|GO:0007059|GO:0051781|GO:0051301|GO:0007017|GO:0006996|GO:0051276|GO:0005730|GO:0015631|GO:0051653|GO:0003677|GO:0000819|GO:0090068|GO:0003723|GO:1903047|GO:0007010|GO:0008017|GO:0000278|GO:0031981|GO:0007346|GO:0010564|GO:0005876|GO:0005694|GO:0051293|GO:0033043|GO:0007067|GO:0045931|GO:0000226|GO:0005856|GO:0000910|GO:0005634|GO:0030261|GO:0005819|GO:0010638|GO:0007088|GO:0007076|GO:0015630|GO:0040001|GO:0000070|GO:0045840|GO:0044822|GO:0071103|GO:0000281|GO:0006323 cell|cellular process|binding|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|regulation of cell cycle|cell cycle|organelle localization|cell cycle process|positive regulation of cellular component organization|nucleic acid binding|regulation of cell division|microtubule|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|protein complex binding|establishment of organelle localization|positive regulation of cell cycle|establishment of localization in cell|cytoskeletal protein binding|chromosome segregation|positive regulation of cell division|cell division|microtubule-based process|organelle organization|chromosome organization|nucleolus|tubulin binding|spindle localization|DNA binding|sister chromatid segregation|positive regulation of cell cycle process|RNA binding|mitotic cell cycle process|cytoskeleton organization|microtubule binding|mitotic cell cycle|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|spindle microtubule|chromosome|establishment of spindle localization|regulation of organelle organization|mitotic nuclear division|positive regulation of mitotic cell cycle|microtubule cytoskeleton organization|cytoskeleton|cytokinesis|nucleus|chromosome condensation|spindle|positive regulation of organelle organization|regulation of mitotic nuclear division|mitotic chromosome condensation|microtubule cytoskeleton|establishment of mitotic spindle localization|mitotic sister chromatid segregation|positive regulation of mitotic nuclear division|poly(A) RNA binding|DNA conformation change|mitotic cytokinesis|DNA packaging - - - - 15:41332694-41381050 505 637 841 1670 1828 1518 5.55122594297129 6.36379826713677 8.33503859953138 16.4479305724226 16.4869899613422 15.6385989093548 6.75002093654648 16.1911731477065 -1.26224363925366 5.32870429893931e-09 1.03502367040035e-07 DOWN ENSG00000127870 RNF6 ring finger protein (C3H2C3 type) 6 [Source:HGNC Symbol;Acc:HGNC:10069] GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0045926|GO:0009653|GO:0016043|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0016874|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0032535|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0043169|GO:0030308|GO:0005737|GO:0005635|GO:0043005|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0048588|GO:0048638|GO:0009725|GO:0048640|GO:0019787|GO:0031965|GO:0030030|GO:0048869|GO:0044249|GO:0019538|GO:0010033|GO:0001558|GO:0031323|GO:0060560|GO:0050768|GO:0000902|GO:0031175|GO:0003677|GO:0031344|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0030424|GO:0043412|GO:0030163|GO:0004842|GO:0051427|GO:0051252|GO:0010721|GO:0044265|GO:0000904|GO:0010628|GO:0036211|GO:0030517|GO:0031345|GO:0031981|GO:0008361|GO:0006508|GO:0005654|GO:0022604|GO:0033143|GO:0014070|GO:0044267|GO:0010467|GO:0030516|GO:0032990|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0009755|GO:0048858|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:1990138|GO:0048545|GO:0051960|GO:0030522|GO:0048666|GO:0030182|GO:0043401|GO:0044257|GO:0045893|GO:0010975|GO:0061630|GO:0010769|GO:0032774|GO:2001141|GO:0035257|GO:0071383|GO:0071407|GO:0016604|GO:0061564|GO:0030518|GO:0051603|GO:0046914|GO:0060765|GO:0045665|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0071396|GO:0010977|GO:0006351|GO:0006355|GO:0050771|GO:0048675|GO:0035258|GO:0007409|GO:0019941|GO:0048699|GO:1903506|GO:0030521|GO:0016605|GO:0050770|GO:0008270|GO:0045664|GO:0032446|GO:0006511|GO:0050681|GO:0016567|GO:0000209|GO:0085020|GO:0070936|GO:0044314 developmental process|growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|negative regulation of growth|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|ligase activity|regulation of developmental process|developmental growth|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|regulation of cellular component size|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|negative regulation of cell growth|cytoplasm|nuclear envelope|neuron projection|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|developmental cell growth|regulation of developmental growth|response to hormone|negative regulation of developmental growth|ubiquitin-like protein transferase activity|nuclear membrane|cell projection organization|cellular developmental process|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|developmental growth involved in morphogenesis|negative regulation of neurogenesis|cell morphogenesis|neuron projection development|DNA binding|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|axon|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|hormone receptor binding|regulation of RNA metabolic process|negative regulation of cell development|cellular macromolecule catabolic process|cell morphogenesis involved in differentiation|positive regulation of gene expression|protein modification process|negative regulation of axon extension|negative regulation of cell projection organization|nuclear lumen|regulation of cell size|proteolysis|nucleoplasm|regulation of cell morphogenesis|regulation of intracellular steroid hormone receptor signaling pathway|response to organic cyclic compound|cellular protein metabolic process|gene expression|regulation of axon extension|cell part morphogenesis|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|cell projection morphogenesis|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|neuron projection extension|response to steroid hormone|regulation of nervous system development|intracellular receptor signaling pathway|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|cellular protein catabolic process|positive regulation of transcription, DNA-templated|regulation of neuron projection development|ubiquitin protein ligase activity|regulation of cell morphogenesis involved in differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|nuclear body|axon development|intracellular steroid hormone receptor signaling pathway|proteolysis involved in cellular protein catabolic process|transition metal ion binding|regulation of androgen receptor signaling pathway|negative regulation of neuron differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|cellular response to lipid|negative regulation of neuron projection development|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of axonogenesis|axon extension|steroid hormone receptor binding|axonogenesis|modification-dependent protein catabolic process|generation of neurons|regulation of nucleic acid-templated transcription|androgen receptor signaling pathway|PML body|regulation of axonogenesis|zinc ion binding|regulation of neuron differentiation|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|androgen receptor binding|protein ubiquitination|protein polyubiquitination|protein K6-linked ubiquitination|protein K48-linked ubiquitination|protein K27-linked ubiquitination - - - - 13:26132115-26222493 3092 3490 2207 1191 1432 1146 18.5905976049177 19.0703772632836 11.9638353566909 6.41598493713254 7.06423128164054 6.45754219839942 16.5416034082974 6.64591947239083 1.31555836706415 5.35101020480654e-09 1.03843842537526e-07 UP ENSG00000136731 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:15663] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0006457|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0006486|GO:0006725|GO:1901360|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0005975|GO:0006139|GO:0005783|GO:0006458|GO:0070062|GO:0016757|GO:0051082|GO:0044249|GO:0019538|GO:0034645|GO:0009225|GO:0043412|GO:0005793|GO:0006487|GO:0008194|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0051084|GO:0005788|GO:0009059|GO:0009101|GO:0046527|GO:0043413|GO:0018279|GO:0006011|GO:0035251|GO:0006464|GO:0097359|GO:0003980|GO:0018193|GO:0043687 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|protein folding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|transferase activity|protein glycosylation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|nucleobase-containing compound metabolic process|endoplasmic reticulum|'de novo' protein folding|extracellular exosome|transferase activity, transferring glycosyl groups|unfolded protein binding|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|nucleotide-sugar metabolic process|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation|UDP-glycosyltransferase activity|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|'de novo' posttranslational protein folding|endoplasmic reticulum lumen|macromolecule biosynthetic process|glycoprotein biosynthetic process|glucosyltransferase activity|macromolecule glycosylation|protein N-linked glycosylation via asparagine|UDP-glucose metabolic process|UDP-glucosyltransferase activity|cellular protein modification process|UDP-glucosylation|UDP-glucose:glycoprotein glucosyltransferase activity|peptidyl-amino acid modification|post-translational protein modification K11718 UDP-glucose:glycoprotein glucosyltransferase [EC:2.4.1.-][-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 2:128091200-128195677 1296 1102 1743 3421 3857 3307 6.33814562234177 4.89800391245617 7.68544255232882 14.9902253422922 15.4765772254958 15.1572498269338 6.30719736237559 15.2080174649073 -1.26976111061079 5.35324156445543e-09 1.03843842537526e-07 DOWN ENSG00000121039 RDH10 retinol dehydrogenase 10 (all-trans) [Source:HGNC Symbol;Acc:HGNC:19975] GO:0032502|GO:0040007|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0051606|GO:0016491|GO:0050794|GO:0043229|GO:0044702|GO:0042175|GO:0071704|GO:0009628|GO:0044237|GO:0042445|GO:0003006|GO:0044297|GO:0009653|GO:0043227|GO:0009605|GO:0009058|GO:0031224|GO:0048589|GO:0005622|GO:0005789|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0045137|GO:0006081|GO:0044255|GO:0035239|GO:0001822|GO:0009888|GO:0048468|GO:0009314|GO:0035295|GO:0006082|GO:0007275|GO:0030324|GO:0048513|GO:0050877|GO:0044281|GO:0016614|GO:0009582|GO:0043231|GO:0048608|GO:0005737|GO:0001763|GO:0007423|GO:0009887|GO:0048729|GO:0048598|GO:0048568|GO:0007548|GO:0030323|GO:0008406|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0048645|GO:0010817|GO:0048869|GO:0016021|GO:0044249|GO:0055114|GO:0060560|GO:0060425|GO:0048705|GO:0043584|GO:0001654|GO:0002009|GO:0009583|GO:0042573|GO:0061458|GO:0001655|GO:0043583|GO:0006720|GO:0006066|GO:0060541|GO:0048754|GO:0061138|GO:0009790|GO:0060431|GO:0001656|GO:0042572|GO:0072001|GO:0007602|GO:0007600|GO:0016616|GO:0060485|GO:0016331|GO:0008299|GO:0042574|GO:0060429|GO:0035108|GO:0048864|GO:0048562|GO:0008610|GO:0003401|GO:0060562|GO:0048701|GO:0030154|GO:0001501|GO:0060173|GO:0048703|GO:0009416|GO:0031076|GO:0060602|GO:0004745|GO:0048706|GO:0060571|GO:0050953|GO:0048863|GO:0002138|GO:0009792|GO:0043010|GO:0014031|GO:0009584|GO:0035136|GO:0019752|GO:0048704|GO:0048762|GO:0060441|GO:0004033|GO:0007603|GO:0030326|GO:0035115|GO:0014033|GO:0008106|GO:0014032|GO:0016101|GO:0043009|GO:0032787|GO:0007601|GO:0060449|GO:0001523|GO:0001701|GO:0052650 developmental process|growth|reproduction|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|detection of stimulus|oxidoreductase activity|regulation of cellular process|intracellular organelle|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|hormone metabolic process|developmental process involved in reproduction|cell body|anatomical structure morphogenesis|membrane-bounded organelle|response to external stimulus|biosynthetic process|intrinsic component of membrane|developmental growth|intracellular|endoplasmic reticulum membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|development of primary sexual characteristics|cellular aldehyde metabolic process|cellular lipid metabolic process|tube morphogenesis|kidney development|tissue development|cell development|response to radiation|tube development|organic acid metabolic process|multicellular organism development|lung development|animal organ development|neurological system process|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|detection of abiotic stimulus|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|morphogenesis of a branching structure|sensory organ development|organ morphogenesis|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|sex differentiation|respiratory tube development|gonad development|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|organ formation|regulation of hormone levels|cellular developmental process|integral component of membrane|cellular biosynthetic process|oxidation-reduction process|developmental growth involved in morphogenesis|lung morphogenesis|skeletal system morphogenesis|nose development|eye development|morphogenesis of an epithelium|detection of light stimulus|retinoic acid metabolic process|reproductive system development|urogenital system development|ear development|isoprenoid metabolic process|alcohol metabolic process|respiratory system development|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|embryo development|primary lung bud formation|metanephros development|retinol metabolic process|renal system development|phototransduction|sensory perception|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|mesenchyme development|morphogenesis of embryonic epithelium|isoprenoid biosynthetic process|retinal metabolic process|epithelium development|limb morphogenesis|stem cell development|embryonic organ morphogenesis|lipid biosynthetic process|axis elongation|epithelial tube morphogenesis|embryonic cranial skeleton morphogenesis|cell differentiation|skeletal system development|limb development|embryonic viscerocranium morphogenesis|response to light stimulus|embryonic camera-type eye development|branch elongation of an epithelium|retinol dehydrogenase activity|embryonic skeletal system development|morphogenesis of an epithelial fold|sensory perception of light stimulus|stem cell differentiation|retinoic acid biosynthetic process|embryo development ending in birth or egg hatching|camera-type eye development|mesenchymal cell development|detection of visible light|forelimb morphogenesis|carboxylic acid metabolic process|embryonic skeletal system morphogenesis|mesenchymal cell differentiation|epithelial tube branching involved in lung morphogenesis|aldo-keto reductase (NADP) activity|phototransduction, visible light|embryonic limb morphogenesis|embryonic forelimb morphogenesis|neural crest cell differentiation|alcohol dehydrogenase (NADP+) activity|neural crest cell development|diterpenoid metabolic process|chordate embryonic development|monocarboxylic acid metabolic process|visual perception|bud elongation involved in lung branching|retinoid metabolic process|in utero embryonic development|NADP-retinol dehydrogenase activity K11151 retinol dehydrogenase 10 [EC:1.1.1.-][-] hsa01100|hsa00830 Metabolic pathways - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human) 8:73294612-73325281 174 171 276 547 607 594 1.85700608049499 1.65859370551882 2.65574458548835 5.23055826629688 5.31520086757414 5.94125964497476 2.05711479050072 5.49567292628193 -1.41767384410156 5.36548514803778e-09 1.04013762084104e-07 DOWN ENSG00000147010 SH3KBP1 SH3-domain kinase binding protein 1 [Source:HGNC Symbol;Acc:HGNC:13867] GO:0040011|GO:0032502|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0030055|GO:0048523|GO:0050794|GO:0043229|GO:0048870|GO:0023051|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0031090|GO:0008360|GO:0006810|GO:0005924|GO:0005912|GO:0031982|GO:0051128|GO:0043231|GO:0005737|GO:0007267|GO:0012506|GO:0006928|GO:0043005|GO:0009966|GO:0019904|GO:0010646|GO:0007154|GO:0016477|GO:0007165|GO:0009968|GO:0008219|GO:0048869|GO:0006996|GO:0016192|GO:0000902|GO:0005829|GO:0007166|GO:0007010|GO:0031410|GO:0017124|GO:0016023|GO:1901184|GO:0031988|GO:0022604|GO:1901185|GO:0012501|GO:0030659|GO:0005856|GO:0005925|GO:0030139|GO:0042058|GO:0007167|GO:0042059|GO:0006897|GO:0006915|GO:0007169|GO:0038127|GO:0007173 locomotion|developmental process|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|intracellular organelle|cell motility|regulation of signaling|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|organelle membrane|regulation of cell shape|transport|cell-substrate adherens junction|adherens junction|vesicle|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|vesicle membrane|movement of cell or subcellular component|neuron projection|regulation of signal transduction|protein domain specific binding|regulation of cell communication|cell communication|cell migration|signal transduction|negative regulation of signal transduction|cell death|cellular developmental process|organelle organization|vesicle-mediated transport|cell morphogenesis|cytosol|cell surface receptor signaling pathway|cytoskeleton organization|cytoplasmic vesicle|SH3 domain binding|cytoplasmic, membrane-bounded vesicle|regulation of ERBB signaling pathway|membrane-bounded vesicle|regulation of cell morphogenesis|negative regulation of ERBB signaling pathway|programmed cell death|cytoplasmic vesicle membrane|cytoskeleton|focal adhesion|endocytic vesicle|regulation of epidermal growth factor receptor signaling pathway|enzyme linked receptor protein signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|endocytosis|apoptotic process|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K12470 SH3 domain-containing kinase-binding protein 1[-] hsa04144 Endocytosis - Homo sapiens (human) X:19533975-19887601 535 574 990 2065 2302 1577 3.7832862233744 3.68899052711203 6.31196668678426 13.0837817190431 13.3563766269808 10.4514382261558 4.59474781242356 12.2971988573932 -1.42027214078309 5.36927292227709e-09 1.04019645568891e-07 DOWN ENSG00000110060 PUS3 pseudouridylate synthase 3 [Source:HGNC Symbol;Acc:HGNC:25461] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016853|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0016866|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0003723|GO:0043412|GO:0009982|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0034660|GO:0009451|GO:0006400|GO:0006399|GO:0001522|GO:0008033|GO:0031119 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|isomerase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|intramolecular transferase activity|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|RNA binding|macromolecule modification|pseudouridine synthase activity|gene expression|RNA metabolic process|nucleus|RNA processing|ncRNA metabolic process|RNA modification|tRNA modification|tRNA metabolic process|pseudouridine synthesis|tRNA processing|tRNA pseudouridine synthesis - - - - 11:125893485-125903221 464 400 398 188 177 157 9.94301642222758 7.79005806753818 7.68948718908046 3.60957757673816 3.1120188003367 3.15304509014219 8.47418722628207 3.29154715573902 1.36430913714076 5.39404082802506e-09 1.04431708741803e-07 UP ENSG00000158156 XKR8 X-linked Kx blood group related 8 [Source:HGNC Symbol;Acc:HGNC:25508] GO:0005623|GO:0016020|GO:0009987|GO:0016043|GO:0071944|GO:0031224|GO:0005886|GO:0097035|GO:0006810|GO:0097194|GO:0061024|GO:0008219|GO:0016021|GO:0010256|GO:0016192|GO:0006909|GO:0070782|GO:0007009|GO:0010324|GO:0012501|GO:0017121|GO:0006911|GO:0043277|GO:0006897|GO:0006915|GO:0043652 cell|membrane|cellular process|cellular component organization|cell periphery|intrinsic component of membrane|plasma membrane|regulation of membrane lipid distribution|transport|execution phase of apoptosis|membrane organization|cell death|integral component of membrane|endomembrane system organization|vesicle-mediated transport|phagocytosis|phosphatidylserine exposure on apoptotic cell surface|plasma membrane organization|membrane invagination|programmed cell death|phospholipid scrambling|phagocytosis, engulfment|apoptotic cell clearance|endocytosis|apoptotic process|engulfment of apoptotic cell - - - - 1:27959462-27968096 428 395 362 162 182 145 10.06494561893 8.44199293413907 7.67521744934397 3.4133568920369 3.51162697976574 3.19568878474932 8.72738533413768 3.37355755218399 1.37127872274873 5.51484633075105e-09 1.06701375475205e-07 UP ENSG00000132842 AP3B1 adaptor related protein complex 3, beta 1 subunit [Source:HGNC Symbol;Acc:HGNC:566] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0050794|GO:0045321|GO:0019882|GO:0043229|GO:0006950|GO:0051641|GO:0016043|GO:0043473|GO:0007155|GO:0043227|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0030119|GO:1903706|GO:0050817|GO:0016337|GO:0045595|GO:0051640|GO:0019884|GO:0050867|GO:0006810|GO:0007275|GO:0048513|GO:0070489|GO:0030155|GO:0031982|GO:0030117|GO:0098609|GO:0045597|GO:0043231|GO:0019899|GO:0005774|GO:0005737|GO:0009611|GO:0012506|GO:0030742|GO:0006928|GO:0051656|GO:0002696|GO:0001775|GO:0045184|GO:0033059|GO:0008104|GO:0046649|GO:0050865|GO:0010970|GO:0051649|GO:0045785|GO:0048869|GO:0007017|GO:0050878|GO:0005794|GO:0006996|GO:0016192|GO:0051650|GO:0051249|GO:0016050|GO:0072594|GO:0030097|GO:0030098|GO:0031410|GO:0030131|GO:0007596|GO:0034109|GO:0015031|GO:0048489|GO:0005773|GO:0016023|GO:0030665|GO:0042060|GO:0046907|GO:0051251|GO:0019902|GO:0022407|GO:0008088|GO:0048753|GO:0007599|GO:0007018|GO:0007159|GO:0031988|GO:0034613|GO:0030118|GO:0042110|GO:0030659|GO:0030123|GO:0051648|GO:0030154|GO:0022409|GO:0072384|GO:0048007|GO:0006623|GO:0002521|GO:0033365|GO:0050863|GO:0032438|GO:0000323|GO:0047496|GO:0030217|GO:0008089|GO:0006605|GO:0045619|GO:0034112|GO:0070486|GO:0046631|GO:0016482|GO:0019903|GO:0006886|GO:0030135|GO:0006622|GO:0072666|GO:0050870|GO:0030705|GO:0007034|GO:0045621|GO:0005765|GO:1903039|GO:0045582|GO:0030136|GO:0007041|GO:0005764|GO:0046632|GO:0045580|GO:0048490|GO:0071593|GO:0046638|GO:0061462|GO:0001865|GO:0051138 developmental process|macromolecular complex|immune system process|cell|membrane|cellular process|response to stimulus|binding|regulation of cellular process|leukocyte activation|antigen processing and presentation|intracellular organelle|response to stress|cellular localization|cellular component organization|pigmentation|cell adhesion|membrane-bounded organelle|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|endomembrane system|anatomical structure development|organelle membrane|AP-type membrane coat adaptor complex|regulation of hemopoiesis|coagulation|single organismal cell-cell adhesion|regulation of cell differentiation|organelle localization|antigen processing and presentation of exogenous antigen|positive regulation of cell activation|transport|multicellular organism development|animal organ development|T cell aggregation|regulation of cell adhesion|vesicle|membrane coat|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|vacuolar membrane|cytoplasm|response to wounding|vesicle membrane|GTP-dependent protein binding|movement of cell or subcellular component|establishment of organelle localization|positive regulation of leukocyte activation|cell activation|establishment of protein localization|cellular pigmentation|protein localization|lymphocyte activation|regulation of cell activation|establishment of localization by movement along microtubule|establishment of localization in cell|positive regulation of cell adhesion|cellular developmental process|microtubule-based process|regulation of body fluid levels|Golgi apparatus|organelle organization|vesicle-mediated transport|establishment of vesicle localization|regulation of lymphocyte activation|vesicle organization|establishment of protein localization to organelle|hemopoiesis|lymphocyte differentiation|cytoplasmic vesicle|clathrin adaptor complex|blood coagulation|homotypic cell-cell adhesion|protein transport|synaptic vesicle transport|vacuole|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|wound healing|intracellular transport|positive regulation of lymphocyte activation|phosphatase binding|regulation of cell-cell adhesion|axo-dendritic transport|pigment granule organization|hemostasis|microtubule-based movement|leukocyte cell-cell adhesion|membrane-bounded vesicle|cellular protein localization|clathrin coat|T cell activation|cytoplasmic vesicle membrane|AP-3 adaptor complex|vesicle localization|cell differentiation|positive regulation of cell-cell adhesion|organelle transport along microtubule|antigen processing and presentation, exogenous lipid antigen via MHC class Ib|protein targeting to vacuole|leukocyte differentiation|protein localization to organelle|regulation of T cell activation|melanosome organization|lytic vacuole|vesicle transport along microtubule|T cell differentiation|anterograde axonal transport|protein targeting|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|alpha-beta T cell activation|cytosolic transport|protein phosphatase binding|intracellular protein transport|coated vesicle|protein targeting to lysosome|establishment of protein localization to vacuole|positive regulation of T cell activation|cytoskeleton-dependent intracellular transport|vacuolar transport|positive regulation of lymphocyte differentiation|lysosomal membrane|positive regulation of leukocyte cell-cell adhesion|positive regulation of T cell differentiation|clathrin-coated vesicle|lysosomal transport|lysosome|alpha-beta T cell differentiation|regulation of T cell differentiation|anterograde synaptic vesicle transport|lymphocyte aggregation|positive regulation of alpha-beta T cell differentiation|protein localization to lysosome|NK T cell differentiation|positive regulation of NK T cell differentiation K12397 AP-3 complex subunit beta[-] hsa04142 Lysosome - Homo sapiens (human) 5:78000525-78294755 480 487 766 1351 1638 1489 3.53500265256562 3.25954675035551 5.08617590950146 8.91458766196623 9.89760886109551 10.2771354310768 3.96024177080753 9.69644398471285 -1.29186725021496 5.64729618463142e-09 1.09193251487038e-07 DOWN ENSG00000136144 RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 [Source:HGNC Symbol;Acc:HGNC:18243] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0051252|GO:0006325|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0016568|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|chromatin organization|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|chromatin modification|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 13:49531946-49585583 180 197 356 630 746 1081 2.41881414878605 2.40589455437587 4.3131431944617 7.58521859039759 8.22501001207645 13.6139659759431 3.04595063254121 9.80806485947238 -1.68707595998363 5.71057123486011e-09 1.1034523860551e-07 DOWN ENSG00000188573 FBLL1 fibrillarin-like 1 [Source:HGNC Symbol;Acc:HGNC:35458] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0016740|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0022613|GO:0019538|GO:0006996|GO:0051276|GO:0005730|GO:0008168|GO:0003723|GO:0030684|GO:0043412|GO:0016571|GO:0006479|GO:0006325|GO:0042254|GO:0005732|GO:0036211|GO:0001510|GO:0031981|GO:0005654|GO:0044267|GO:0010467|GO:0016070|GO:0005634|GO:0006364|GO:0006396|GO:0034660|GO:0032040|GO:0031167|GO:0009451|GO:1990258|GO:0016604|GO:0018364|GO:0031428|GO:0008276|GO:0016568|GO:0006464|GO:0008173|GO:0008757|GO:0008170|GO:0008649|GO:0016074|GO:0015030|GO:0006399|GO:0042054|GO:0016072|GO:0000154|GO:0031123|GO:0008033|GO:1990259|GO:0000494 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|protein metabolic process|organelle organization|chromosome organization|nucleolus|methyltransferase activity|RNA binding|preribosome|macromolecule modification|histone methylation|protein methylation|chromatin organization|ribosome biogenesis|small nucleolar ribonucleoprotein complex|protein modification process|RNA methylation|nuclear lumen|nucleoplasm|cellular protein metabolic process|gene expression|RNA metabolic process|nucleus|rRNA processing|RNA processing|ncRNA metabolic process|small-subunit processome|rRNA methylation|RNA modification|histone glutamine methylation|nuclear body|peptidyl-glutamine methylation|box C/D snoRNP complex|protein methyltransferase activity|chromatin modification|cellular protein modification process|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|N-methyltransferase activity|rRNA methyltransferase activity|snoRNA metabolic process|Cajal body|tRNA metabolic process|histone methyltransferase activity|rRNA metabolic process|rRNA modification|RNA 3'-end processing|tRNA processing|histone-glutamine methyltransferase activity|box C/D snoRNA 3'-end processing - - - - 5:168529116-168530634 17 15 11 1 0 0 0.791641672543288 0.634851847165183 0.461833573263318 0.0417042748524108 0 0 0.62944236432393 0.0139014249508036 5.50076960425463 5.7696400359309e-09 1.11414510758526e-07 UP ENSG00000175054 ATR ATR serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:882] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0023051|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:0007049|GO:0006281|GO:0006725|GO:0009314|GO:0022402|GO:1901360|GO:2001022|GO:0007275|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0009408|GO:0032403|GO:0009966|GO:0009890|GO:0042493|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0000166|GO:0048869|GO:0009967|GO:0044249|GO:0009266|GO:0019538|GO:0031324|GO:0031323|GO:0005794|GO:0007568|GO:1900034|GO:1902533|GO:0003677|GO:0000075|GO:0034645|GO:0051053|GO:0000725|GO:0035639|GO:0043412|GO:0001883|GO:0006302|GO:0036211|GO:0036297|GO:0032549|GO:0043517|GO:0007569|GO:0031981|GO:2001020|GO:0071478|GO:0034605|GO:0005654|GO:0006259|GO:0005694|GO:0016301|GO:0006796|GO:0010212|GO:0035556|GO:0044267|GO:0017076|GO:0009059|GO:1902531|GO:0016773|GO:0005634|GO:0009416|GO:0006974|GO:0000724|GO:0010332|GO:0008156|GO:0006260|GO:1901798|GO:0009411|GO:0072331|GO:0042770|GO:0005524|GO:0032407|GO:0030554|GO:0016310|GO:0032405|GO:0000077|GO:0016604|GO:0071482|GO:0006275|GO:0006310|GO:1901796|GO:0090399|GO:0004672|GO:0071479|GO:0006464|GO:0043516|GO:0006468|GO:0071480|GO:0018193|GO:0016605|GO:0004674|GO:0034644|GO:0030330|GO:0046777|GO:0018105 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|cell cycle|DNA repair|cellular aromatic compound metabolic process|response to radiation|cell cycle process|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|response to heat|protein complex binding|regulation of signal transduction|negative regulation of biosynthetic process|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|nucleotide binding|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|aging|regulation of cellular response to heat|positive regulation of intracellular signal transduction|DNA binding|cell cycle checkpoint|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|recombinational repair|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|double-strand break repair|protein modification process|interstrand cross-link repair|ribonucleoside binding|positive regulation of DNA damage response, signal transduction by p53 class mediator|cell aging|nuclear lumen|regulation of response to DNA damage stimulus|cellular response to radiation|cellular response to heat|nucleoplasm|DNA metabolic process|chromosome|kinase activity|phosphate-containing compound metabolic process|response to ionizing radiation|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|macromolecule biosynthetic process|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|nucleus|response to light stimulus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|response to gamma radiation|negative regulation of DNA replication|DNA replication|positive regulation of signal transduction by p53 class mediator|response to UV|signal transduction by p53 class mediator|signal transduction in response to DNA damage|ATP binding|MutSalpha complex binding|adenyl nucleotide binding|phosphorylation|MutLalpha complex binding|DNA damage checkpoint|nuclear body|cellular response to light stimulus|regulation of DNA replication|DNA recombination|regulation of signal transduction by p53 class mediator|replicative senescence|protein kinase activity|cellular response to ionizing radiation|cellular protein modification process|regulation of DNA damage response, signal transduction by p53 class mediator|protein phosphorylation|cellular response to gamma radiation|peptidyl-amino acid modification|PML body|protein serine/threonine kinase activity|cellular response to UV|DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|peptidyl-serine phosphorylation K06640 serine/threonine-protein kinase ATR[2.7.11.1] hsa05166|hsa04110|hsa04115|hsa03460 HTLV-I infection - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human)|Fanconi anemia pathway - Homo sapiens (human) 3:142449235-142578826 547 724 729 1572 1839 1527 2.49552280611035 3.00187472135195 2.99857884947178 6.42575724933362 6.88372688151694 6.52892784307306 2.83199212564469 6.61280399130787 -1.22344488558436 5.79309764945137e-09 1.11795175970731e-07 DOWN ENSG00000118246 FASTKD2 FAST kinase domains 2 [Source:HGNC Symbol;Acc:HGNC:29160] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0016740|GO:0042645|GO:0003676|GO:0015980|GO:0016772|GO:0022607|GO:0043231|GO:0005737|GO:0030529|GO:0006091|GO:0022613|GO:0019538|GO:0006996|GO:0055114|GO:0035770|GO:0003723|GO:0043412|GO:0042254|GO:0036211|GO:0022618|GO:0005759|GO:0005739|GO:0016301|GO:0070925|GO:0006796|GO:0044267|GO:0042273|GO:0045333|GO:0016773|GO:0034622|GO:0042255|GO:0019843|GO:0016310|GO:0000027|GO:0004672|GO:0044822|GO:0006464|GO:1902775|GO:0006468|GO:0061668 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|transferase activity|mitochondrial nucleoid|nucleic acid binding|energy derivation by oxidation of organic compounds|transferase activity, transferring phosphorus-containing groups|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|generation of precursor metabolites and energy|ribonucleoprotein complex biogenesis|protein metabolic process|organelle organization|oxidation-reduction process|ribonucleoprotein granule|RNA binding|macromolecule modification|ribosome biogenesis|protein modification process|ribonucleoprotein complex assembly|mitochondrial matrix|mitochondrion|kinase activity|organelle assembly|phosphate-containing compound metabolic process|cellular protein metabolic process|ribosomal large subunit biogenesis|cellular respiration|phosphotransferase activity, alcohol group as acceptor|cellular macromolecular complex assembly|ribosome assembly|rRNA binding|phosphorylation|ribosomal large subunit assembly|protein kinase activity|poly(A) RNA binding|cellular protein modification process|mitochondrial large ribosomal subunit assembly|protein phosphorylation|mitochondrial ribosome assembly - - - - 2:206765357-206792509 118 173 170 608 610 341 1.01273452967446 1.34939743804136 1.31545763722717 4.67535501343298 4.29547232609628 2.74281240521936 1.22586320164766 3.90454658158287 -1.67135703140698 5.84595722311831e-09 1.12742381743523e-07 DOWN ENSG00000267534 S1PR2 sphingosine-1-phosphate receptor 2 [Source:HGNC Symbol;Acc:HGNC:3169] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0071704|GO:0044237|GO:0038023|GO:0023051|GO:0016043|GO:0008289|GO:0071944|GO:0023057|GO:0009893|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0050804|GO:0042391|GO:0045595|GO:0009888|GO:0048468|GO:0007275|GO:0005102|GO:0031325|GO:0022607|GO:0045597|GO:0004888|GO:0007267|GO:0032403|GO:0009966|GO:0050839|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0009968|GO:0050790|GO:0030030|GO:0050805|GO:0048869|GO:0016021|GO:0030029|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0006996|GO:0000165|GO:1902533|GO:0032268|GO:0007186|GO:0007166|GO:0043412|GO:0007010|GO:0010720|GO:0002064|GO:0060078|GO:0051347|GO:0036211|GO:0030856|GO:0005178|GO:0030031|GO:0051247|GO:0001664|GO:0030858|GO:0030036|GO:0032270|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0098815|GO:0051246|GO:0030154|GO:0090394|GO:1902531|GO:0004930|GO:0003158|GO:0001885|GO:0031401|GO:0031532|GO:0030855|GO:0043408|GO:0045125|GO:0016310|GO:0003376|GO:0046847|GO:0043410|GO:0060079|GO:0045603|GO:0006464|GO:0045601|GO:0043549|GO:0033674|GO:0061028|GO:0045446|GO:0045859|GO:0045860|GO:0043406|GO:0006468|GO:1903140|GO:0043405|GO:0042325|GO:0001932|GO:0018193|GO:0001934|GO:1903142|GO:0038036|GO:0042327|GO:0007268|GO:0000187|GO:0071902|GO:0071900|GO:0018107|GO:0032147|GO:0010800 developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|organic substance metabolic process|cellular metabolic process|signaling receptor activity|regulation of signaling|cellular component organization|lipid binding|cell periphery|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|modulation of synaptic transmission|regulation of membrane potential|regulation of cell differentiation|tissue development|cell development|multicellular organism development|receptor binding|positive regulation of cellular metabolic process|cellular component assembly|positive regulation of cell differentiation|transmembrane signaling receptor activity|cell-cell signaling|protein complex binding|regulation of signal transduction|cell adhesion molecule binding|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|negative regulation of signal transduction|regulation of catalytic activity|cell projection organization|negative regulation of synaptic transmission|cellular developmental process|integral component of membrane|actin filament-based process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|organelle organization|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|macromolecule modification|cytoskeleton organization|positive regulation of cell development|epithelial cell development|regulation of postsynaptic membrane potential|positive regulation of transferase activity|protein modification process|regulation of epithelial cell differentiation|integrin binding|cell projection assembly|positive regulation of protein metabolic process|G-protein coupled receptor binding|positive regulation of epithelial cell differentiation|actin cytoskeleton organization|positive regulation of cellular protein metabolic process|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|modulation of excitatory postsynaptic potential|regulation of protein metabolic process|cell differentiation|negative regulation of excitatory postsynaptic potential|regulation of intracellular signal transduction|G-protein coupled receptor activity|endothelium development|endothelial cell development|positive regulation of protein modification process|actin cytoskeleton reorganization|epithelial cell differentiation|regulation of MAPK cascade|bioactive lipid receptor activity|phosphorylation|sphingosine-1-phosphate signaling pathway|filopodium assembly|positive regulation of MAPK cascade|excitatory postsynaptic potential|positive regulation of endothelial cell differentiation|cellular protein modification process|regulation of endothelial cell differentiation|regulation of kinase activity|positive regulation of kinase activity|establishment of endothelial barrier|endothelial cell differentiation|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|protein phosphorylation|regulation of establishment of endothelial barrier|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|positive regulation of establishment of endothelial barrier|sphingosine-1-phosphate receptor activity|positive regulation of phosphorylation|synaptic transmission|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|activation of protein kinase activity|positive regulation of peptidyl-threonine phosphorylation K04292 sphingosine 1-phosphate receptor 2[-] hsa04080|hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human) 19:10221435-10231272 303 360 558 146 159 173 5.98361156281461 6.4610353848311 9.93501355031094 2.58327300098762 2.57622635757556 3.20179907463799 7.45988683265222 2.78709947773372 1.42038924846366 5.87277822740016e-09 1.13186521110913e-07 UP ENSG00000122692 SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) [Source:HGNC Symbol;Acc:HGNC:18247] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nucleus - - - - 9:33041764-33076659 410 484 552 1156 1386 1018 4.0721828177093 4.36887321757728 4.94307079826362 10.2872458583588 11.2947032947557 9.47589873695103 4.4613756111834 10.3526159633552 -1.21443484153107 5.97983073564961e-09 1.15175397923925e-07 DOWN ENSG00000011485 PPP5C protein phosphatase 5, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9322] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042802|GO:0007049|GO:0006281|GO:0006935|GO:0045087|GO:0006725|GO:0048468|GO:0043025|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0016570|GO:0003676|GO:0034641|GO:0043168|GO:0016788|GO:0006952|GO:1990635|GO:0001882|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0001965|GO:0006928|GO:0032403|GO:0043005|GO:0009966|GO:0043204|GO:0036477|GO:0006979|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0008092|GO:0009725|GO:0008219|GO:0050790|GO:0031072|GO:0000166|GO:0030030|GO:0048869|GO:0010035|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0071774|GO:0000165|GO:0051276|GO:1902533|GO:0015631|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0034645|GO:1901215|GO:0046872|GO:0003723|GO:0007166|GO:0033993|GO:0035639|GO:1903047|GO:0043412|GO:0042542|GO:0006325|GO:0001883|GO:0070997|GO:1901652|GO:0000904|GO:0008017|GO:0071417|GO:0010038|GO:0006302|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0032549|GO:0043531|GO:0043279|GO:0031981|GO:0043434|GO:0034599|GO:0030425|GO:0044344|GO:0051247|GO:0070848|GO:0005654|GO:0006259|GO:0033143|GO:0002764|GO:0006461|GO:1901214|GO:0032270|GO:0014070|GO:0000302|GO:0006796|GO:0035556|GO:0060359|GO:0071241|GO:0044267|GO:0051174|GO:0007067|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0017076|GO:0051246|GO:0009059|GO:0030154|GO:0009755|GO:0048858|GO:0016576|GO:1902531|GO:0016070|GO:0032870|GO:0005634|GO:0042578|GO:0048545|GO:0006974|GO:0030522|GO:0048666|GO:0030182|GO:0043401|GO:0007411|GO:0016311|GO:0031401|GO:0043122|GO:0008543|GO:0051259|GO:2000324|GO:0046686|GO:1901653|GO:0043408|GO:0032774|GO:0005524|GO:0071363|GO:0030554|GO:0016310|GO:0002768|GO:0038179|GO:0071383|GO:0071407|GO:0061564|GO:0030518|GO:0007167|GO:0043123|GO:0007249|GO:0043278|GO:0071375|GO:0043410|GO:0010288|GO:0016791|GO:0016568|GO:0032868|GO:0034614|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0071396|GO:0043549|GO:0006351|GO:0070301|GO:0071248|GO:0033674|GO:0048011|GO:0006470|GO:0000186|GO:0071276|GO:0007265|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0051291|GO:0043405|GO:0042325|GO:0004721|GO:0001932|GO:0032869|GO:0042326|GO:0038093|GO:0001934|GO:0001933|GO:0042327|GO:0007169|GO:0048010|GO:0004722|GO:0042921|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|regulation of immune system process|protein binding|protein complex|anatomical structure development|regulation of metabolic process|identical protein binding|cell cycle|DNA repair|chemotaxis|innate immune response|cellular aromatic compound metabolic process|cell development|neuronal cell body|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|defense response|proximal dendrite|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|G-protein alpha-subunit binding|movement of cell or subcellular component|protein complex binding|neuron projection|regulation of signal transduction|perikaryon|somatodendritic compartment|response to oxidative stress|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|cytoskeletal protein binding|response to hormone|cell death|regulation of catalytic activity|heat shock protein binding|nucleotide binding|cell projection organization|cellular developmental process|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|response to fibroblast growth factor|MAPK cascade|chromosome organization|positive regulation of intracellular signal transduction|tubulin binding|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|cellular macromolecule biosynthetic process|negative regulation of neuron death|metal ion binding|RNA binding|cell surface receptor signaling pathway|response to lipid|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|response to hydrogen peroxide|chromatin organization|purine nucleoside binding|neuron death|response to peptide|cell morphogenesis involved in differentiation|microtubule binding|cellular response to organonitrogen compound|response to metal ion|double-strand break repair|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|ribonucleoside binding|ADP binding|response to alkaloid|nuclear lumen|response to peptide hormone|cellular response to oxidative stress|dendrite|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|nucleoplasm|DNA metabolic process|regulation of intracellular steroid hormone receptor signaling pathway|immune response-regulating signaling pathway|protein complex assembly|regulation of neuron death|positive regulation of cellular protein metabolic process|response to organic cyclic compound|response to reactive oxygen species|phosphate-containing compound metabolic process|intracellular signal transduction|response to ammonium ion|cellular response to inorganic substance|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|cell projection morphogenesis|histone dephosphorylation|regulation of intracellular signal transduction|RNA metabolic process|cellular response to hormone stimulus|nucleus|phosphoric ester hydrolase activity|response to steroid hormone|cellular response to DNA damage stimulus|intracellular receptor signaling pathway|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|axon guidance|dephosphorylation|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|fibroblast growth factor receptor signaling pathway|protein oligomerization|positive regulation of glucocorticoid receptor signaling pathway|response to cadmium ion|cellular response to peptide|regulation of MAPK cascade|RNA biosynthetic process|ATP binding|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|axon development|intracellular steroid hormone receptor signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|response to morphine|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|response to lead ion|phosphatase activity|chromatin modification|response to insulin|cellular response to reactive oxygen species|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|cellular response to lipid|regulation of kinase activity|transcription, DNA-templated|cellular response to hydrogen peroxide|cellular response to metal ion|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|protein dephosphorylation|activation of MAPKK activity|cellular response to cadmium ion|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|protein heterooligomerization|regulation of MAP kinase activity|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|cellular response to insulin stimulus|negative regulation of phosphorylation|Fc receptor signaling pathway|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|protein serine/threonine phosphatase activity|glucocorticoid receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K04460 serine/threonine-protein phosphatase 5[3.1.3.16] hsa04010 MAPK signaling pathway - Homo sapiens (human) 19:46346994-46392981 516 579 698 1612 1659 1251 2.28683924979165 2.33208309807901 2.78904489516274 6.40100695562729 6.03253792356077 5.19603433034176 2.46932241434447 5.87652640317661 -1.2508484158611 5.99973070614387e-09 1.15484178272869e-07 DOWN ENSG00000153487 ING1 inhibitor of growth family member 1 [Source:HGNC Symbol;Acc:HGNC:6062] GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0045926|GO:0016043|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0042127|GO:0007049|GO:0006725|GO:0042393|GO:0006810|GO:1901360|GO:0010941|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0043169|GO:0030308|GO:0005737|GO:0045184|GO:0006139|GO:0008104|GO:0051649|GO:0008219|GO:0008285|GO:0044249|GO:0001558|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0046872|GO:0072594|GO:0051252|GO:0006325|GO:0015031|GO:0010628|GO:0046907|GO:0031981|GO:0005654|GO:0034613|GO:0010467|GO:0017038|GO:0035064|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0006606|GO:0045893|GO:0033365|GO:0051169|GO:0032774|GO:2001141|GO:0006605|GO:0006886|GO:0046914|GO:0016568|GO:0006351|GO:0006355|GO:0006913|GO:1903506|GO:0008270|GO:0034504|GO:0051170 growth|cell|cellular process|metabolic process|binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|negative regulation of growth|cellular component organization|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|histone binding|transport|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|negative regulation of cell growth|cytoplasm|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|establishment of localization in cell|cell death|negative regulation of cell proliferation|cellular biosynthetic process|regulation of cell growth|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|establishment of protein localization to organelle|regulation of RNA metabolic process|chromatin organization|protein transport|positive regulation of gene expression|intracellular transport|nuclear lumen|nucleoplasm|cellular protein localization|gene expression|protein import|methylated histone binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|protein import into nucleus|positive regulation of transcription, DNA-templated|protein localization to organelle|nuclear transport|RNA biosynthetic process|regulation of RNA biosynthetic process|protein targeting|intracellular protein transport|transition metal ion binding|chromatin modification|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|regulation of nucleic acid-templated transcription|zinc ion binding|protein localization to nucleus|nuclear import - - - - 13:110712736-110723339 822 913 832 474 329 311 6.02858532320337 6.08547413915646 5.50149689433252 3.11472247218734 1.9797354736862 2.13763358550909 5.87185211889745 2.41069717712754 1.28436519842956 6.01481067940185e-09 1.15699844086896e-07 UP ENSG00000106603 COA1 cytochrome c oxidase assembly factor 1 homolog [Source:HGNC Symbol;Acc:HGNC:21868] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0003676|GO:0034641|GO:0022607|GO:0043231|GO:0005737|GO:0030529|GO:0031966|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0006996|GO:0005740|GO:0005829|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0005840|GO:0097031|GO:0005743|GO:0031304|GO:0005739|GO:0006461|GO:0015934|GO:0043603|GO:0032592|GO:0044267|GO:0010467|GO:0009059|GO:0043043|GO:0034622|GO:0032981|GO:0022626|GO:0043623|GO:0031305|GO:0006412|GO:0022625|GO:0033108|GO:0033617|GO:0017004|GO:0010257|GO:0008535 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|nucleic acid binding|cellular nitrogen compound metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|organelle organization|mitochondrial envelope|cytosol|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|ribosome|mitochondrial respiratory chain complex I biogenesis|mitochondrial inner membrane|intrinsic component of mitochondrial inner membrane|mitochondrion|protein complex assembly|large ribosomal subunit|cellular amide metabolic process|integral component of mitochondrial membrane|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|peptide biosynthetic process|cellular macromolecular complex assembly|mitochondrial respiratory chain complex I assembly|cytosolic ribosome|cellular protein complex assembly|integral component of mitochondrial inner membrane|translation|cytosolic large ribosomal subunit|mitochondrial respiratory chain complex assembly|mitochondrial respiratory chain complex IV assembly|cytochrome complex assembly|NADH dehydrogenase complex assembly|respiratory chain complex IV assembly - - - - 7:43608456-43729717 330 420 446 994 963 959 1.31614433626956 1.52236850036789 1.60375941354551 3.55201012574403 3.15126115267953 3.58457364738538 1.48075741672765 3.42928164193631 -1.21157108336019 6.0356110113564e-09 1.16025197123654e-07 DOWN ENSG00000069956 MAPK6 mitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:HGNC:6879] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0005057|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0007049|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0019899|GO:0005737|GO:0046983|GO:0007154|GO:0007165|GO:0004702|GO:0000166|GO:0019538|GO:0023014|GO:0000165|GO:0005829|GO:0035639|GO:0043412|GO:0046982|GO:0001883|GO:0036211|GO:0032549|GO:0004707|GO:0031981|GO:0005654|GO:0016301|GO:0019900|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0016773|GO:0005634|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0019901|GO:0006464|GO:0006468|GO:0004674 signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|receptor signaling protein activity|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|cell cycle|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein dimerization activity|cell communication|signal transduction|receptor signaling protein serine/threonine kinase activity|nucleotide binding|protein metabolic process|signal transduction by protein phosphorylation|MAPK cascade|cytosol|purine ribonucleoside triphosphate binding|macromolecule modification|protein heterodimerization activity|purine nucleoside binding|protein modification process|ribonucleoside binding|MAP kinase activity|nuclear lumen|nucleoplasm|kinase activity|kinase binding|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|protein kinase binding|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 15:51952106-52067372 2082 2330 2583 1148 1338 1120 15.8342224422983 16.1046765285646 17.7114722114498 7.82268382975901 8.34910896565198 7.98294194539268 16.5501237274376 8.05157824693456 1.039498493606 6.08991552687653e-09 1.16993782586468e-07 UP ENSG00000135972 MRPS9 mitochondrial ribosomal protein S9 [Source:HGNC Symbol;Acc:HGNC:14501] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0051606|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0031090|GO:0006725|GO:0019866|GO:1901360|GO:0003676|GO:0034641|GO:0042769|GO:0046483|GO:0033554|GO:0005761|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0031966|GO:0006139|GO:0044249|GO:0022613|GO:0019538|GO:0006996|GO:0005730|GO:0005740|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0005840|GO:0042254|GO:0005743|GO:0031981|GO:0005759|GO:0005739|GO:0070124|GO:0043603|GO:0044267|GO:0042274|GO:0010467|GO:0005763|GO:0009059|GO:0015935|GO:0016070|GO:0005634|GO:0006974|GO:0032543|GO:0006364|GO:0043241|GO:0043043|GO:0030490|GO:0006396|GO:0070125|GO:0034660|GO:0006412|GO:0044822|GO:0070126|GO:0006414|GO:0043624|GO:0000462|GO:0016072|GO:0006415 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|detection of stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|DNA damage response, detection of DNA damage|heterocycle metabolic process|cellular response to stress|mitochondrial ribosome|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|nucleobase-containing compound metabolic process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|organelle organization|nucleolus|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|ribosome|ribosome biogenesis|mitochondrial inner membrane|nuclear lumen|mitochondrial matrix|mitochondrion|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|ribosomal small subunit biogenesis|gene expression|mitochondrial small ribosomal subunit|macromolecule biosynthetic process|small ribosomal subunit|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|mitochondrial translation|rRNA processing|protein complex disassembly|peptide biosynthetic process|maturation of SSU-rRNA|RNA processing|mitochondrial translational elongation|ncRNA metabolic process|translation|poly(A) RNA binding|mitochondrial translational termination|translational elongation|cellular protein complex disassembly|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA metabolic process|translational termination K02996 small subunit ribosomal protein S9[-] hsa03010 Ribosome - Homo sapiens (human) 2:105037983-105099960 250 289 377 842 912 661 7.07084600896763 7.42865282907195 9.61363114490223 21.3374180667803 21.1638632014389 17.5211427433838 8.03770999431394 20.0074746705343 -1.31568265268107 6.12642708380316e-09 1.17619520360038e-07 DOWN ENSG00000144677 CTDSPL CTD small phosphatase like [Source:HGNC Symbol;Acc:HGNC:16890] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0019222|GO:0051726|GO:0007049|GO:0022402|GO:0016788|GO:0031982|GO:0045786|GO:0043231|GO:0043169|GO:0070062|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0046872|GO:1903047|GO:0043412|GO:0044770|GO:0036211|GO:0032269|GO:0000278|GO:0007346|GO:0010564|GO:0045930|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0005634|GO:0042578|GO:0010948|GO:0016311|GO:0044772|GO:0016310|GO:1901990|GO:0016791|GO:1901987|GO:0006464|GO:1901991|GO:0006470|GO:2000045|GO:0006468|GO:0042325|GO:0004721|GO:0001932|GO:1902806|GO:0042326|GO:2000134|GO:0000082|GO:0001933|GO:1902807 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|regulation of metabolic process|regulation of cell cycle|cell cycle|cell cycle process|hydrolase activity, acting on ester bonds|vesicle|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|extracellular exosome|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|metal ion binding|mitotic cell cycle process|macromolecule modification|cell cycle phase transition|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|nucleus|phosphoric ester hydrolase activity|negative regulation of cell cycle process|dephosphorylation|mitotic cell cycle phase transition|phosphorylation|regulation of mitotic cell cycle phase transition|phosphatase activity|regulation of cell cycle phase transition|cellular protein modification process|negative regulation of mitotic cell cycle phase transition|protein dephosphorylation|regulation of G1/S transition of mitotic cell cycle|protein phosphorylation|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|negative regulation of phosphorylation|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of protein phosphorylation|negative regulation of cell cycle G1/S phase transition - - - - 3:37861960-37984469 573 678 1108 1877 2264 2222 5.18845622201001 5.5794740986847 9.04560668289908 15.228091776085 16.8200743490035 18.856298210176 6.60451233453126 16.9681547784215 -1.36130574139668 6.28753849979297e-09 1.20597804575716e-07 DOWN ENSG00000178222 RNF212 ring finger protein 212 [Source:HGNC Symbol;Acc:HGNC:27729] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0007049|GO:0007131|GO:0006725|GO:0022402|GO:1901360|GO:0006311|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0070192|GO:0006139|GO:0007126|GO:0007059|GO:0019538|GO:0006996|GO:0051276|GO:0046872|GO:0043412|GO:0007129|GO:0036211|GO:0007127|GO:0031981|GO:0045132|GO:0006259|GO:0005694|GO:0000228|GO:0044267|GO:0005634|GO:0051026|GO:0000793|GO:0000794|GO:0045143|GO:0006310|GO:0046914|GO:0000795|GO:0006464|GO:0018193|GO:0008270|GO:0032446|GO:0018205|GO:0016925 reproduction|cell|cellular process|reproductive process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|ligase activity|intracellular|protein binding|cell cycle|reciprocal meiotic recombination|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|meiotic gene conversion|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|chromosome organization involved in meiotic cell cycle|nucleobase-containing compound metabolic process|meiotic nuclear division|chromosome segregation|protein metabolic process|organelle organization|chromosome organization|metal ion binding|macromolecule modification|synapsis|protein modification process|meiosis I|nuclear lumen|meiotic chromosome segregation|DNA metabolic process|chromosome|nuclear chromosome|cellular protein metabolic process|nucleus|chiasma assembly|condensed chromosome|condensed nuclear chromosome|homologous chromosome segregation|DNA recombination|transition metal ion binding|synaptonemal complex|cellular protein modification process|peptidyl-amino acid modification|zinc ion binding|protein modification by small protein conjugation|peptidyl-lysine modification|protein sumoylation - - - - 4:1056250-1113562 84 81 139 289 364 317 0.696341770941223 0.610254528660787 1.03889787979668 2.14654368690505 2.47578692006583 2.46281382919272 0.781831393132897 2.36171481205453 -1.59490534326804 6.28963561748477e-09 1.20597804575716e-07 DOWN ENSG00000048707 VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23595] GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0019898|GO:0043227|GO:0005515|GO:0031982|GO:0070062 membrane|extracellular region|binding|extracellular vesicle|extrinsic component of membrane|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 1:12230067-12512047 131 165 382 737 786 1270 0.380321257639132 0.435355438855093 0.999902118923083 1.91709901395617 1.87227554869742 3.45550889153549 0.605192938472436 2.41496115139636 -1.99653292206145 6.35263306454501e-09 1.21727540121262e-07 DOWN ENSG00000186073 C15orf41 chromosome 15 open reading frame 41 [Source:HGNC Symbol;Acc:HGNC:26929] - - - - - - 15:36579611-36810248 110 121 192 318 679 563 0.39717335659449 0.397059566955504 0.625034569016401 1.02875840072691 2.01153090574947 1.90513647864743 0.473089164188798 1.64847526170794 -1.8009482146618 6.38657446406108e-09 1.22299418890365e-07 DOWN ENSG00000142230 SAE1 SUMO1 activating enzyme subunit 1 [Source:HGNC Symbol;Acc:HGNC:30660] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0030234|GO:0016874|GO:0005622|GO:1903829|GO:0005515|GO:0043234|GO:0019222|GO:0060341|GO:0051726|GO:0007049|GO:0008022|GO:0006810|GO:0051130|GO:0008047|GO:0051128|GO:0043231|GO:0043008|GO:0005737|GO:0032880|GO:0051222|GO:0046983|GO:0045184|GO:0032388|GO:0043085|GO:0008104|GO:0051649|GO:0090316|GO:0050790|GO:0019538|GO:0006996|GO:0005829|GO:0043412|GO:0072594|GO:0007005|GO:0046982|GO:0032386|GO:0051223|GO:0031510|GO:1903955|GO:0015031|GO:0036211|GO:0000278|GO:0070201|GO:0046907|GO:0031981|GO:0007346|GO:0005654|GO:0034613|GO:0008641|GO:0033043|GO:0044267|GO:0006626|GO:1903827|GO:0005634|GO:0010638|GO:0033365|GO:0033157|GO:0006839|GO:0006605|GO:0072655|GO:0010822|GO:0004839|GO:0016482|GO:0006886|GO:0010821|GO:0019948|GO:0006464|GO:1903214|GO:1903533|GO:0018193|GO:0043687|GO:0070585|GO:0032446|GO:0018205|GO:0016925|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|ligase activity|intracellular|positive regulation of cellular protein localization|protein binding|protein complex|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|cell cycle|protein C-terminus binding|transport|positive regulation of cellular component organization|enzyme activator activity|regulation of cellular component organization|intracellular membrane-bounded organelle|ATP-dependent protein binding|cytoplasm|regulation of protein localization|positive regulation of protein transport|protein dimerization activity|establishment of protein localization|positive regulation of intracellular transport|positive regulation of catalytic activity|protein localization|establishment of localization in cell|positive regulation of intracellular protein transport|regulation of catalytic activity|protein metabolic process|organelle organization|cytosol|macromolecule modification|establishment of protein localization to organelle|mitochondrion organization|protein heterodimerization activity|regulation of intracellular transport|regulation of protein transport|SUMO activating enzyme complex|positive regulation of protein targeting to mitochondrion|protein transport|protein modification process|mitotic cell cycle|regulation of establishment of protein localization|intracellular transport|nuclear lumen|regulation of mitotic cell cycle|nucleoplasm|cellular protein localization|small protein activating enzyme activity|regulation of organelle organization|cellular protein metabolic process|protein targeting to mitochondrion|regulation of cellular protein localization|nucleus|positive regulation of organelle organization|protein localization to organelle|regulation of intracellular protein transport|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|ubiquitin activating enzyme activity|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|SUMO activating enzyme activity|cellular protein modification process|regulation of protein targeting to mitochondrion|regulation of protein targeting|peptidyl-amino acid modification|post-translational protein modification|protein localization to mitochondrion|protein modification by small protein conjugation|peptidyl-lysine modification|protein sumoylation|protein ubiquitination K10684 ubiquitin-like 1-activating enzyme E1 A[6.2.1.45] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 19:47113274-47210636 888 1104 1462 2917 3107 2579 7.92109954347063 8.94997518208375 11.7580213213696 23.3134546694152 22.7395416767985 21.5601985398811 9.54303201564133 22.5377316286983 -1.2398227010753 6.42342196151394e-09 1.22926178999383e-07 DOWN ENSG00000104388 RAB2A RAB2A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9763] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0042175|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0007049|GO:0006810|GO:0043168|GO:0001882|GO:0031982|GO:0016817|GO:0043231|GO:0005774|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0070062|GO:0051649|GO:0000166|GO:0010256|GO:0005794|GO:0006996|GO:0035639|GO:0005793|GO:0007030|GO:0031410|GO:0001883|GO:0015031|GO:0005773|GO:0033116|GO:0016023|GO:0016818|GO:0000278|GO:0046907|GO:0032549|GO:0031988|GO:0034613|GO:0035556|GO:0000139|GO:0017076|GO:0019003|GO:0005634|GO:0032561|GO:0051169|GO:0000323|GO:0006886|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0005765|GO:0006913|GO:0005764|GO:0017111|GO:0042470|GO:0003924 signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|cell cycle|transport|anion binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|endoplasmic reticulum|extracellular exosome|establishment of localization in cell|nucleotide binding|endomembrane system organization|Golgi apparatus|organelle organization|purine ribonucleoside triphosphate binding|endoplasmic reticulum-Golgi intermediate compartment|Golgi organization|cytoplasmic vesicle|purine nucleoside binding|protein transport|vacuole|endoplasmic reticulum-Golgi intermediate compartment membrane|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|intracellular transport|ribonucleoside binding|membrane-bounded vesicle|cellular protein localization|intracellular signal transduction|Golgi membrane|purine nucleotide binding|GDP binding|nucleus|guanyl ribonucleotide binding|nuclear transport|lytic vacuole|intracellular protein transport|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|lysosomal membrane|nucleocytoplasmic transport|lysosome|nucleoside-triphosphatase activity|melanosome|GTPase activity K07877 Ras-related protein Rab-2A[-] hsa04152 AMPK signaling pathway - Homo sapiens (human) 8:60516857-60623627 630 655 564 1542 1760 1497 5.38865764773396 5.09168238046534 4.34944218249022 11.8174129009583 12.3515316136179 12.0002711360659 4.94326073689651 12.0564052168807 -1.28626490208304 6.49310954407059e-09 1.24100699314138e-07 DOWN ENSG00000165632 TAF3 TATA-box binding protein associated factor 3 [Source:HGNC Symbol;Acc:HGNC:17303] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0016032|GO:0006725|GO:1901360|GO:0002039|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0051651|GO:0005667|GO:0009890|GO:0006139|GO:0008104|GO:0044092|GO:0044249|GO:0031324|GO:0031323|GO:0051090|GO:0010468|GO:0034645|GO:0046872|GO:0044798|GO:0010629|GO:0051252|GO:0031981|GO:1990234|GO:0032507|GO:0005654|GO:0043433|GO:0034613|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0033365|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0005669|GO:0046914|GO:0090575|GO:0016591|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006352|GO:0006357|GO:1903506|GO:0006354|GO:0051457|GO:0000122|GO:0008270|GO:0034504|GO:0006367|GO:0006368 macromolecular complex|cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|p53 binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|maintenance of location in cell|transcription factor complex|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|protein localization|negative regulation of molecular function|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|nuclear transcription factor complex|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|transferase complex|maintenance of protein location in cell|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|cellular protein localization|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|protein localization to organelle|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription factor TFIID complex|transition metal ion binding|RNA polymerase II transcription factor complex|DNA-directed RNA polymerase II, holoenzyme|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|DNA-templated transcription, elongation|maintenance of protein location in nucleus|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|protein localization to nucleus|transcription initiation from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter K14650 transcription initiation factor TFIID subunit 3[-] hsa05168|hsa03022 Herpes simplex infection - Homo sapiens (human)|Basal transcription factors - Homo sapiens (human) 10:7818504-8016627 44 69 74 230 257 171 0.638836061497754 0.910479119070949 0.968686853663654 2.99201214160009 3.06153489725923 2.32682118115719 0.839334011410786 2.79345607333884 -1.73473418646141 6.48993791040801e-09 1.24100699314138e-07 DOWN ENSG00000277117 CH507-9B2.1 ICOS ligand [Source:UniProtKB/Swiss-Prot;Acc:O75144] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0008283|GO:0050794|GO:0045321|GO:0006950|GO:0006955|GO:0009628|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0002684|GO:0002682|GO:0005515|GO:0005886|GO:0008284|GO:0042127|GO:0002250|GO:0016337|GO:0070661|GO:0050867|GO:0070489|GO:0005102|GO:0006952|GO:0030155|GO:0031982|GO:0098609|GO:0002696|GO:0001775|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0070062|GO:0045785|GO:0006970|GO:0031295|GO:0016021|GO:0051249|GO:0042113|GO:0032943|GO:0034109|GO:0051251|GO:0022407|GO:0007159|GO:0006972|GO:0042110|GO:0046651|GO:0022409|GO:0042098|GO:0050863|GO:0034112|GO:0070486|GO:0050870|GO:0050671|GO:1903039|GO:0032946|GO:0050798|GO:0042129|GO:0071593|GO:0042102|GO:0046006|GO:0042104 immune system process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell proliferation|regulation of cellular process|leukocyte activation|response to stress|immune response|response to abiotic stimulus|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|positive regulation of immune system process|regulation of immune system process|protein binding|plasma membrane|positive regulation of cell proliferation|regulation of cell proliferation|adaptive immune response|single organismal cell-cell adhesion|leukocyte proliferation|positive regulation of cell activation|T cell aggregation|receptor binding|defense response|regulation of cell adhesion|vesicle|cell-cell adhesion|positive regulation of leukocyte activation|cell activation|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|extracellular exosome|positive regulation of cell adhesion|response to osmotic stress|T cell costimulation|integral component of membrane|regulation of lymphocyte activation|B cell activation|mononuclear cell proliferation|homotypic cell-cell adhesion|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|hyperosmotic response|T cell activation|lymphocyte proliferation|positive regulation of cell-cell adhesion|T cell proliferation|regulation of T cell activation|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|positive regulation of T cell activation|positive regulation of lymphocyte proliferation|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|activated T cell proliferation|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of T cell proliferation|regulation of activated T cell proliferation|positive regulation of activated T cell proliferation - - - - 21:5022493-5040666 36 49 69 174 177 179 0.438756166097818 0.542747799195774 0.758198736258206 1.9000488704888 1.76994728806193 2.04456052280668 0.579900900517266 1.90485222711914 -1.71580079826666 6.7283627438551e-09 1.28514741749872e-07 DOWN ENSG00000169946 ZFPM2 zinc finger protein, FOG family member 2 [Source:HGNC Symbol;Acc:HGNC:16700] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0000989|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0048514|GO:0007507|GO:0045137|GO:0050817|GO:0045595|GO:2000020|GO:0003712|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0030324|GO:0060411|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0061061|GO:0043231|GO:0048608|GO:0043169|GO:0005737|GO:0000981|GO:0009611|GO:0001076|GO:2000194|GO:0009887|GO:0048729|GO:0048568|GO:0007548|GO:0009890|GO:0030323|GO:0060548|GO:0006139|GO:0008406|GO:0003151|GO:0003279|GO:0008134|GO:0008219|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0050878|GO:0003205|GO:2000195|GO:0003713|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0008584|GO:0003714|GO:0046872|GO:0003208|GO:0001944|GO:0008585|GO:0046661|GO:0061458|GO:0072358|GO:0001104|GO:0003148|GO:0001085|GO:0010629|GO:0007498|GO:0007596|GO:0051252|GO:0060541|GO:0048738|GO:0003007|GO:0009790|GO:0046545|GO:0010628|GO:0045599|GO:0060412|GO:0060537|GO:0042060|GO:0060485|GO:0031981|GO:0003231|GO:0007599|GO:0001570|GO:0005654|GO:0007506|GO:0010467|GO:0001227|GO:0045598|GO:0060415|GO:0031328|GO:0009059|GO:0030154|GO:0003281|GO:0007517|GO:0001191|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0046546|GO:0048644|GO:0045893|GO:0045444|GO:0009792|GO:0001078|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0001105|GO:0046914|GO:0003215|GO:0003229|GO:0055008|GO:0014706|GO:0055010|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0001190|GO:0003221|GO:0043009|GO:0000122|GO:0008270|GO:0001701 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|blood vessel morphogenesis|heart development|development of primary sexual characteristics|coagulation|regulation of cell differentiation|positive regulation of male gonad development|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|lung development|cardiac septum morphogenesis|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|reproductive structure development|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|response to wounding|transcription factor activity, RNA polymerase II transcription factor binding|regulation of female gonad development|organ morphogenesis|tissue morphogenesis|embryonic organ development|sex differentiation|negative regulation of biosynthetic process|respiratory tube development|negative regulation of cell death|nucleobase-containing compound metabolic process|gonad development|outflow tract morphogenesis|cardiac septum development|transcription factor binding|cell death|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|cardiac chamber development|negative regulation of female gonad development|transcription coactivator activity|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gonad development|transcription corepressor activity|metal ion binding|cardiac ventricle morphogenesis|vasculature development|female gonad development|male sex differentiation|reproductive system development|cardiovascular system development|RNA polymerase II transcription cofactor activity|outflow tract septum morphogenesis|RNA polymerase II transcription factor binding|negative regulation of gene expression|mesoderm development|blood coagulation|regulation of RNA metabolic process|respiratory system development|cardiac muscle tissue development|heart morphogenesis|embryo development|development of primary female sexual characteristics|positive regulation of gene expression|negative regulation of fat cell differentiation|ventricular septum morphogenesis|muscle tissue development|wound healing|mesenchyme development|nuclear lumen|cardiac ventricle development|hemostasis|vasculogenesis|nucleoplasm|gonadal mesoderm development|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of fat cell differentiation|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|ventricular septum development|muscle organ development|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|development of primary male sexual characteristics|muscle organ morphogenesis|positive regulation of transcription, DNA-templated|fat cell differentiation|embryo development ending in birth or egg hatching|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|RNA polymerase II transcription coactivator activity|transition metal ion binding|cardiac right ventricle morphogenesis|ventricular cardiac muscle tissue development|cardiac muscle tissue morphogenesis|striated muscle tissue development|ventricular cardiac muscle tissue morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcriptional activator activity, RNA polymerase II transcription factor binding|right ventricular cardiac muscle tissue morphogenesis|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|in utero embryonic development K17442 zinc finger protein ZFPM2[-] hsa05206 MicroRNAs in cancer - Homo sapiens (human) 8:104590733-105804532 0 4 2 21 29 22 0 0.0158119171319116 0.00784333173420814 0.0818401184060448 0.103491239156988 0.0896819743319808 0.00788508295537325 0.0916711106316712 -3.53926931426605 6.91864297878478e-09 1.32064685095039e-07 DOWN ENSG00000234545 FAM133B family with sequence similarity 133 member B [Source:HGNC Symbol;Acc:HGNC:28629] GO:0005488|GO:0097159|GO:0003676|GO:0003723|GO:0044822 binding|organic cyclic compound binding|nucleic acid binding|RNA binding|poly(A) RNA binding - - - - 7:92560793-92590394 735 872 648 369 349 272 5.54222228883233 5.97575826268674 4.40540557725302 2.49298935446876 2.15918859658874 1.92218092727344 5.30779537625736 2.19145295944365 1.2762250425738 6.92971290213408e-09 1.32191468997004e-07 UP ENSG00000151466 SCLT1 sodium channel and clathrin linker 1 [Source:HGNC Symbol;Acc:HGNC:26406] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0042995|GO:0043229|GO:0009653|GO:0016043|GO:0043227|GO:0016247|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0048468|GO:0008022|GO:0007275|GO:0031982|GO:0071439|GO:0030276|GO:0022607|GO:0030117|GO:0005737|GO:0061024|GO:0070062|GO:0017080|GO:0030030|GO:0048869|GO:0097539|GO:0006996|GO:0000902|GO:0005829|GO:0005813|GO:0005815|GO:0005814|GO:0044782|GO:0045161|GO:0030031|GO:0070925|GO:0030118|GO:0042384|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0048469|GO:0005856|GO:0048666|GO:0030182|GO:0060271|GO:0042551|GO:0015630|GO:0022008|GO:0045162|GO:0048699 developmental process|macromolecular complex|cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|cell projection|intracellular organelle|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|channel regulator activity|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|cell development|protein C-terminus binding|multicellular organism development|vesicle|clathrin complex|clathrin binding|cellular component assembly|membrane coat|cytoplasm|membrane organization|extracellular exosome|sodium channel regulator activity|cell projection organization|cellular developmental process|ciliary transition fiber|organelle organization|cell morphogenesis|cytosol|centrosome|microtubule organizing center|centriole|cilium organization|neuronal ion channel clustering|cell projection assembly|organelle assembly|clathrin coat|cilium assembly|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|cell maturation|cytoskeleton|neuron development|neuron differentiation|cilium morphogenesis|neuron maturation|microtubule cytoskeleton|neurogenesis|clustering of voltage-gated sodium channels|generation of neurons - - - - 4:128864921-129093607 79 93 106 311 338 231 0.45834837485451 0.490382998524551 0.554484355855513 1.61669717187493 1.60899649003993 1.25606226496996 0.501071909744858 1.49391864229494 -1.57601201496964 6.94159785746203e-09 1.32333628631335e-07 DOWN ENSG00000244754 N4BP2L2 NEDD4 binding protein 2-like 2 [Source:HGNC Symbol;Acc:HGNC:26916] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0000988|GO:1903561|GO:0002683|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:1903706|GO:0045595|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0045596|GO:0048513|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0019899|GO:0001076|GO:0017053|GO:0009890|GO:0006139|GO:0070062|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0072089|GO:0010468|GO:0034645|GO:0003714|GO:1901533|GO:2000736|GO:0030097|GO:0001104|GO:0010629|GO:0051252|GO:1902035|GO:1902033|GO:0010467|GO:2000737|GO:0009059|GO:0030154|GO:0001191|GO:0016070|GO:0005634|GO:2000648|GO:0071425|GO:0072091|GO:1901532|GO:0048863|GO:0045892|GO:1902036|GO:0032774|GO:2001141|GO:1902679|GO:1902037|GO:0002244|GO:0001106|GO:0006351|GO:0006355|GO:0060218|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 developmental process|macromolecular complex|immune system process|cell|cellular process|extracellular region|metabolic process|binding|transcription factor activity, protein binding|extracellular vesicle|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|regulation of hemopoiesis|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|transcription factor activity, RNA polymerase II transcription factor binding|transcriptional repressor complex|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|extracellular exosome|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|stem cell proliferation|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|negative regulation of hematopoietic progenitor cell differentiation|regulation of stem cell differentiation|hemopoiesis|RNA polymerase II transcription cofactor activity|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of hematopoietic stem cell proliferation|regulation of hematopoietic stem cell proliferation|gene expression|negative regulation of stem cell differentiation|macromolecule biosynthetic process|cell differentiation|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|nucleus|positive regulation of stem cell proliferation|hematopoietic stem cell proliferation|regulation of stem cell proliferation|regulation of hematopoietic progenitor cell differentiation|stem cell differentiation|negative regulation of transcription, DNA-templated|regulation of hematopoietic stem cell differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|negative regulation of hematopoietic stem cell differentiation|hematopoietic progenitor cell differentiation|RNA polymerase II transcription corepressor activity|transcription, DNA-templated|regulation of transcription, DNA-templated|hematopoietic stem cell differentiation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 13:32432417-32538885 330 377 651 1106 1239 1460 0.913804499826848 0.948770534682602 1.62530477596492 2.74405365470008 2.81500497853522 3.78897307232482 1.16262660349146 3.11601056852004 -1.42231230042961 6.95341597367496e-09 1.32474333425713e-07 DOWN ENSG00000070214 SLC44A1 solute carrier family 44 (choline transporter), member 1 [Source:HGNC Symbol;Acc:HGNC:18798] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:1903561|GO:0022857|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0019867|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005886|GO:0031090|GO:0044255|GO:0006810|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0043231|GO:0005737|GO:0031966|GO:0022891|GO:0055085|GO:0006629|GO:0070062|GO:0016021|GO:0044249|GO:0005740|GO:0008654|GO:0046486|GO:0005741|GO:0006066|GO:0009308|GO:0006811|GO:0046470|GO:0015075|GO:0031981|GO:0005654|GO:0005739|GO:0006796|GO:0008610|GO:0005634|GO:0006644|GO:0006656|GO:0046474|GO:0006812|GO:0015696|GO:0015871|GO:0006576|GO:0015220|GO:0006650|GO:0008324|GO:0022890|GO:0015672|GO:0015077|GO:0008519 transporter activity|cell|membrane|cellular process|extracellular region|metabolic process|extracellular vesicle|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|outer membrane|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|plasma membrane|organelle membrane|cellular lipid metabolic process|transport|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|substrate-specific transmembrane transporter activity|transmembrane transport|lipid metabolic process|extracellular exosome|integral component of membrane|cellular biosynthetic process|mitochondrial envelope|phospholipid biosynthetic process|glycerolipid metabolic process|mitochondrial outer membrane|alcohol metabolic process|amine metabolic process|ion transport|phosphatidylcholine metabolic process|ion transmembrane transporter activity|nuclear lumen|nucleoplasm|mitochondrion|phosphate-containing compound metabolic process|lipid biosynthetic process|nucleus|phospholipid metabolic process|phosphatidylcholine biosynthetic process|glycerophospholipid biosynthetic process|cation transport|ammonium transport|choline transport|cellular biogenic amine metabolic process|choline transmembrane transporter activity|glycerophospholipid metabolic process|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|monovalent inorganic cation transport|monovalent inorganic cation transmembrane transporter activity|ammonium transmembrane transporter activity K06515 solute carrier family 44 (choline transporter-like protein), member 1[-] hsa05231 Choline metabolism in cancer - Homo sapiens (human) 9:105244622-105439171 751 1055 1065 2187 2329 2763 1.8595418146057 2.37409671546457 2.37755028511362 4.8519068916541 4.73154939826477 6.41173701131567 2.2037296050613 5.33173110041151 -1.27465680379015 7.06052976730746e-09 1.34429244689539e-07 DOWN ENSG00000168297 PXK PX domain containing serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:23326] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0009892|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0051051|GO:0044237|GO:0023051|GO:0043227|GO:0008289|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0019222|GO:0050804|GO:0042391|GO:0008022|GO:0006810|GO:0043168|GO:0006952|GO:0005543|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0007267|GO:0010646|GO:0007154|GO:0044092|GO:0008092|GO:0050790|GO:0000166|GO:0043086|GO:0019538|GO:0043271|GO:0035639|GO:0043412|GO:0035091|GO:0005815|GO:0001883|GO:0003779|GO:0036211|GO:0006811|GO:0006954|GO:0032549|GO:0051346|GO:0016301|GO:0043269|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005856|GO:0005634|GO:0032780|GO:0005524|GO:0030554|GO:0016310|GO:0015630|GO:0004672|GO:0006464|GO:0043462|GO:0006468|GO:0007268 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|negative regulation of transport|cellular metabolic process|regulation of signaling|membrane-bounded organelle|lipid binding|cell periphery|intracellular|protein binding|plasma membrane|protein complex|transferase activity|regulation of metabolic process|modulation of synaptic transmission|regulation of membrane potential|protein C-terminus binding|transport|anion binding|defense response|phospholipid binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|regulation of cell communication|cell communication|negative regulation of molecular function|cytoskeletal protein binding|regulation of catalytic activity|nucleotide binding|negative regulation of catalytic activity|protein metabolic process|negative regulation of ion transport|purine ribonucleoside triphosphate binding|macromolecule modification|phosphatidylinositol binding|microtubule organizing center|purine nucleoside binding|actin binding|protein modification process|ion transport|inflammatory response|ribonucleoside binding|negative regulation of hydrolase activity|kinase activity|regulation of ion transport|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|negative regulation of ATPase activity|ATP binding|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|protein kinase activity|cellular protein modification process|regulation of ATPase activity|protein phosphorylation|synaptic transmission - - - - 3:58332880-58426126 22 27 51 113 142 170 0.127047485166832 0.141708513412748 0.265538454510718 0.584685438062712 0.672824958338894 0.920074050879265 0.178098151030099 0.725861482426957 -2.02702172333454 7.06877771848676e-09 1.34500503510327e-07 DOWN ENSG00000144355 DLX1 distal-less homeobox 1 [Source:HGNC Symbol;Acc:HGNC:2914] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0043227|GO:0023057|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0021544|GO:0045595|GO:0006725|GO:0048468|GO:0021766|GO:1901360|GO:0010941|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0030900|GO:0046483|GO:0007420|GO:0043231|GO:0007389|GO:0060322|GO:0009887|GO:0009966|GO:0009890|GO:0003682|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0021543|GO:0048869|GO:0021537|GO:0044249|GO:0031324|GO:0031323|GO:0050768|GO:0003677|GO:0010468|GO:0034645|GO:1901215|GO:0007166|GO:0007417|GO:0021895|GO:0010629|GO:0043069|GO:0051252|GO:0070997|GO:0010721|GO:0021761|GO:0009790|GO:0003002|GO:0008593|GO:1901214|GO:0021872|GO:0012501|GO:0042476|GO:0010467|GO:0007399|GO:0009059|GO:0030154|GO:0001501|GO:0016070|GO:0005634|GO:0043067|GO:0051960|GO:0045165|GO:0045746|GO:0030182|GO:0021953|GO:0048706|GO:0000975|GO:0021892|GO:0009792|GO:0010001|GO:0045892|GO:0043523|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0048663|GO:0048709|GO:0042981|GO:0043066|GO:0042475|GO:0051402|GO:0060850|GO:0021879|GO:0043524|GO:0009954|GO:0007219|GO:0022008|GO:0050767|GO:0006351|GO:0006915|GO:0006355|GO:0048715|GO:0045686|GO:0006366|GO:1903507|GO:0021877|GO:0006357|GO:0048699|GO:0014013|GO:1903506|GO:0045685|GO:0044212|GO:0021882|GO:0042063|GO:0043009|GO:0000122|GO:0097154|GO:0048713|GO:0021893|GO:0000976|GO:0001012|GO:0000977 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|subpallium development|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|hippocampus development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|forebrain development|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|pattern specification process|head development|organ morphogenesis|regulation of signal transduction|negative regulation of biosynthetic process|chromatin binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|cell death|pallium development|cellular developmental process|telencephalon development|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of neurogenesis|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of neuron death|cell surface receptor signaling pathway|central nervous system development|cerebral cortex neuron differentiation|negative regulation of gene expression|negative regulation of programmed cell death|regulation of RNA metabolic process|neuron death|negative regulation of cell development|limbic system development|embryo development|regionalization|regulation of Notch signaling pathway|regulation of neuron death|forebrain generation of neurons|programmed cell death|odontogenesis|gene expression|nervous system development|macromolecule biosynthetic process|cell differentiation|skeletal system development|RNA metabolic process|nucleus|regulation of programmed cell death|regulation of nervous system development|cell fate commitment|negative regulation of Notch signaling pathway|neuron differentiation|central nervous system neuron differentiation|embryonic skeletal system development|regulatory region DNA binding|cerebral cortex GABAergic interneuron differentiation|embryo development ending in birth or egg hatching|glial cell differentiation|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|neuron fate commitment|oligodendrocyte differentiation|regulation of apoptotic process|negative regulation of apoptotic process|odontogenesis of dentin-containing tooth|neuron apoptotic process|regulation of transcription involved in cell fate commitment|forebrain neuron differentiation|negative regulation of neuron apoptotic process|proximal/distal pattern formation|Notch signaling pathway|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|negative regulation of oligodendrocyte differentiation|negative regulation of glial cell differentiation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|forebrain neuron fate commitment|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of gliogenesis|regulation of nucleic acid-templated transcription|regulation of glial cell differentiation|transcription regulatory region DNA binding|regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment|gliogenesis|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|GABAergic neuron differentiation|regulation of oligodendrocyte differentiation|cerebral cortex GABAergic interneuron fate commitment|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 2:172084740-172089677 64 62 40 8 10 15 0.561123799148396 0.494027358564986 0.316194265185275 0.0628466560305748 0.0719384965850014 0.123255728082124 0.457115140966219 0.0860136268992334 2.40992046074649 7.10982909841224e-09 1.35195438155413e-07 UP ENSG00000100036 SLC35E4 solute carrier family 35 member E4 [Source:HGNC Symbol;Acc:HGNC:17058] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 22:30635652-30669016 315 342 433 152 166 161 3.26477646496409 3.22142964264348 4.04618251382604 1.41151194215072 1.41162066547682 1.56386004748282 3.51079620714454 1.46233088503679 1.26352846362805 7.1145979493912e-09 1.35200004571053e-07 UP ENSG00000125657 TNFSF9 tumor necrosis factor superfamily member 9 [Source:HGNC Symbol;Acc:HGNC:11939] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0045321|GO:0006955|GO:0007155|GO:0071944|GO:0031224|GO:0005615|GO:0002684|GO:0050793|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0008284|GO:0042127|GO:1903706|GO:0016337|GO:0045595|GO:0070661|GO:0050867|GO:0007275|GO:0048513|GO:0070489|GO:0005102|GO:0030155|GO:0001817|GO:0098609|GO:0045597|GO:0001816|GO:0007267|GO:0002696|GO:0001775|GO:0001819|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0045785|GO:0008219|GO:0048869|GO:0016021|GO:0032735|GO:0051249|GO:0005126|GO:0032943|GO:0032675|GO:0030097|GO:0030098|GO:0032635|GO:0034109|GO:0032655|GO:0005125|GO:0032755|GO:0032615|GO:0051251|GO:0022407|GO:0007159|GO:0042110|GO:0012501|GO:0032609|GO:0046651|GO:0030154|GO:0022409|GO:0032729|GO:0001773|GO:0032649|GO:0002521|GO:0043011|GO:0042098|GO:0050863|GO:0032813|GO:0030217|GO:0045619|GO:0034112|GO:0070486|GO:0030099|GO:0050870|GO:0045621|GO:0050671|GO:0006915|GO:1903039|GO:0032946|GO:0045065|GO:0045582|GO:0005164|GO:0097028|GO:0002573|GO:0045580|GO:0050798|GO:0042129|GO:0071593|GO:0042102|GO:0045585|GO:0046006|GO:0042104 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|leukocyte activation|immune response|cell adhesion|cell periphery|intrinsic component of membrane|extracellular space|positive regulation of immune system process|regulation of developmental process|regulation of immune system process|immune system development|protein binding|plasma membrane|anatomical structure development|positive regulation of cell proliferation|regulation of cell proliferation|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of cell differentiation|leukocyte proliferation|positive regulation of cell activation|multicellular organism development|animal organ development|T cell aggregation|receptor binding|regulation of cell adhesion|regulation of cytokine production|cell-cell adhesion|positive regulation of cell differentiation|cytokine production|cell-cell signaling|positive regulation of leukocyte activation|cell activation|positive regulation of cytokine production|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|positive regulation of cell adhesion|cell death|cellular developmental process|integral component of membrane|positive regulation of interleukin-12 production|regulation of lymphocyte activation|cytokine receptor binding|mononuclear cell proliferation|regulation of interleukin-6 production|hemopoiesis|lymphocyte differentiation|interleukin-6 production|homotypic cell-cell adhesion|regulation of interleukin-12 production|cytokine activity|positive regulation of interleukin-6 production|interleukin-12 production|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|T cell activation|programmed cell death|interferon-gamma production|lymphocyte proliferation|cell differentiation|positive regulation of cell-cell adhesion|positive regulation of interferon-gamma production|myeloid dendritic cell activation|regulation of interferon-gamma production|leukocyte differentiation|myeloid dendritic cell differentiation|T cell proliferation|regulation of T cell activation|tumor necrosis factor receptor superfamily binding|T cell differentiation|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|myeloid cell differentiation|positive regulation of T cell activation|positive regulation of lymphocyte differentiation|positive regulation of lymphocyte proliferation|apoptotic process|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|cytotoxic T cell differentiation|positive regulation of T cell differentiation|tumor necrosis factor receptor binding|dendritic cell differentiation|myeloid leukocyte differentiation|regulation of T cell differentiation|activated T cell proliferation|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of T cell proliferation|positive regulation of cytotoxic T cell differentiation|regulation of activated T cell proliferation|positive regulation of activated T cell proliferation K05472 tumor necrosis factor ligand superfamily member 9[-] hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) 19:6530999-6535928 524 607 855 179 204 338 22.2619277894954 23.4368905625544 32.750029650201 6.81370568555986 7.11098123033139 13.4578994640749 26.1496160007503 9.12752879332205 1.51849354123916 7.32636619671937e-09 1.39135710201565e-07 UP ENSG00000143476 DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) [Source:HGNC Symbol;Acc:HGNC:30288] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0051606|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0009314|GO:0022402|GO:1901360|GO:0034641|GO:0042769|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0005635|GO:0006139|GO:0019787|GO:0031965|GO:0000151|GO:0044249|GO:0019538|GO:0005730|GO:0005813|GO:0000075|GO:0034645|GO:0043412|GO:0030163|GO:0004842|GO:0031461|GO:0019985|GO:0005815|GO:0044265|GO:0036211|GO:0031981|GO:1990234|GO:0006508|GO:0005654|GO:0006259|GO:0005694|GO:0006301|GO:0044267|GO:0009059|GO:0005856|GO:0005634|GO:0009416|GO:0006974|GO:0044257|GO:0006260|GO:0009411|GO:0000077|GO:0051603|GO:0015630|GO:0080008|GO:0006464|GO:0071897|GO:0031465|GO:0019941|GO:0031464|GO:0031572|GO:0032446|GO:0006511|GO:0016567|GO:0006513|GO:0000209 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|detection of stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|transferase activity|organelle membrane|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|response to radiation|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|DNA damage response, detection of DNA damage|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|nucleobase-containing compound metabolic process|ubiquitin-like protein transferase activity|nuclear membrane|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|nucleolus|centrosome|cell cycle checkpoint|cellular macromolecule biosynthetic process|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|translesion synthesis|microtubule organizing center|cellular macromolecule catabolic process|protein modification process|nuclear lumen|transferase complex|proteolysis|nucleoplasm|DNA metabolic process|chromosome|postreplication repair|cellular protein metabolic process|macromolecule biosynthetic process|cytoskeleton|nucleus|response to light stimulus|cellular response to DNA damage stimulus|cellular protein catabolic process|DNA replication|response to UV|DNA damage checkpoint|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|Cul4-RING E3 ubiquitin ligase complex|cellular protein modification process|DNA biosynthetic process|Cul4B-RING E3 ubiquitin ligase complex|modification-dependent protein catabolic process|Cul4A-RING E3 ubiquitin ligase complex|G2 DNA damage checkpoint|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein monoubiquitination|protein polyubiquitination - - - - 1:212035553-212107400 346 415 431 1180 1453 766 2.89850061773998 3.15955243811839 3.25528654107879 8.85681021622397 9.98691209327711 6.01388293070443 3.10444653231239 8.28586841340184 -1.41631682481715 7.38994900638644e-09 1.40253997226104e-07 DOWN ENSG00000143067 ZNF697 zinc finger protein 697 [Source:HGNC Symbol;Acc:HGNC:32034] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 1:119619422-119647773 469 635 797 281 311 276 6.5811541668297 8.09808911820413 10.0832782877371 3.53291221176475 3.58061406823578 3.62967521861009 8.25417385759031 3.58106716620354 1.20473424815509 7.44526608026458e-09 1.4121408739531e-07 UP ENSG00000162542 TMCO4 transmembrane and coiled-coil domains 4 [Source:HGNC Symbol;Acc:HGNC:27393] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 1:19682213-19799945 61 64 100 251 233 242 0.640489721412975 0.610715056117032 0.946663455983951 2.36129568049772 2.00726137631895 2.38135599928298 0.732622744504653 2.24997101869988 -1.61876402279899 7.49135181622268e-09 1.41997979124769e-07 DOWN ENSG00000167306 MYO5B myosin VB [Source:HGNC Symbol;Acc:HGNC:7603] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0043229|GO:0043167|GO:0051641|GO:0045177|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0003014|GO:0051640|GO:0006810|GO:0045179|GO:0005938|GO:0043168|GO:0001882|GO:0031982|GO:0016817|GO:0043231|GO:0019899|GO:0005737|GO:0012506|GO:0042592|GO:0045184|GO:0048871|GO:0016459|GO:0008104|GO:0005516|GO:0055085|GO:0070062|GO:0008092|GO:0000166|GO:0050878|GO:0005768|GO:0016192|GO:0035639|GO:0031410|GO:0050891|GO:0048878|GO:0001883|GO:0003779|GO:0015031|GO:0016023|GO:0016818|GO:0003091|GO:0032549|GO:0055037|GO:0032439|GO:0031988|GO:0030659|GO:0017076|GO:0051020|GO:0005856|GO:0042044|GO:0015629|GO:0005524|GO:0030554|GO:0030104|GO:0031267|GO:0016462|GO:0006833|GO:0017016|GO:0017111|GO:0017137|GO:0003774|GO:0000146 macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|ion binding|cellular localization|apical part of cell|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|renal system process|organelle localization|transport|apical cortex|cell cortex|anion binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|vesicle membrane|homeostatic process|establishment of protein localization|multicellular organismal homeostasis|myosin complex|protein localization|calmodulin binding|transmembrane transport|extracellular exosome|cytoskeletal protein binding|nucleotide binding|regulation of body fluid levels|endosome|vesicle-mediated transport|purine ribonucleoside triphosphate binding|cytoplasmic vesicle|multicellular organismal water homeostasis|chemical homeostasis|purine nucleoside binding|actin binding|protein transport|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|renal water homeostasis|ribonucleoside binding|recycling endosome|endosome localization|membrane-bounded vesicle|cytoplasmic vesicle membrane|purine nucleotide binding|GTPase binding|cytoskeleton|fluid transport|actin cytoskeleton|ATP binding|adenyl nucleotide binding|water homeostasis|small GTPase binding|pyrophosphatase activity|water transport|Ras GTPase binding|nucleoside-triphosphatase activity|Rab GTPase binding|motor activity|microfilament motor activity - - - - 18:49822813-50195093 303 312 355 745 798 1024 1.70633680582772 1.59681858519781 1.80245530593317 3.75902908175279 3.68716359113767 5.40443720990223 1.70187023231957 4.28354329426423 -1.33168363438829 7.50610627366754e-09 1.42187370998776e-07 DOWN ENSG00000101246 ARFRP1 ADP ribosylation factor related protein 1 [Source:HGNC Symbol;Acc:HGNC:662] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0006810|GO:0007275|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005737|GO:0048598|GO:0045184|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0051649|GO:0000166|GO:0010256|GO:0005794|GO:0016192|GO:0090150|GO:0005802|GO:0035639|GO:0001883|GO:0015031|GO:0009790|GO:0007009|GO:0016818|GO:0007369|GO:0046907|GO:0032549|GO:0072657|GO:0034613|GO:0035556|GO:0017076|GO:0032561|GO:0033365|GO:0072659|GO:0090002|GO:0042147|GO:0048193|GO:0016482|GO:0006886|GO:0016197|GO:0005525|GO:0007264|GO:0019001|GO:1990778|GO:0016462|GO:0043001|GO:0034067|GO:0017111|GO:0006892|GO:0003924|GO:0006893 developmental process|signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|endomembrane system|anatomical structure development|transport|multicellular organism development|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|embryonic morphogenesis|establishment of protein localization|protein localization|cell communication|membrane organization|signal transduction|establishment of localization in cell|nucleotide binding|endomembrane system organization|Golgi apparatus|vesicle-mediated transport|establishment of protein localization to membrane|trans-Golgi network|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|embryo development|plasma membrane organization|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|gastrulation|intracellular transport|ribonucleoside binding|protein localization to membrane|cellular protein localization|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|protein localization to organelle|protein localization to plasma membrane|establishment of protein localization to plasma membrane|retrograde transport, endosome to Golgi|Golgi vesicle transport|cytosolic transport|intracellular protein transport|endosomal transport|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|protein localization to cell periphery|pyrophosphatase activity|Golgi to plasma membrane protein transport|protein localization to Golgi apparatus|nucleoside-triphosphatase activity|post-Golgi vesicle-mediated transport|GTPase activity|Golgi to plasma membrane transport - - - - 20:63698642-63708025 149 164 182 540 464 406 0.588683972095248 0.588869389017392 0.648306061306589 1.9115564276069 1.50411714306037 1.50331755067989 0.608619807473076 1.63966370711572 -1.42978675821439 7.51946355221764e-09 1.42350072852191e-07 DOWN ENSG00000163428 LRRC58 leucine rich repeat containing 58 [Source:HGNC Symbol;Acc:HGNC:26968] GO:0005488|GO:0005515 binding|protein binding - - - - 3:120324509-120349339 3505 4384 4789 2010 2486 1913 31.3719727532458 35.6618875630185 38.6467393815441 16.1193493381666 18.2567224710418 16.0471425652493 35.2268665659361 16.8077381248192 1.06755056344231 7.60395442355876e-09 1.43858336730623e-07 UP ENSG00000125246 CLYBL citrate lyase beta like [Source:HGNC Symbol;Acc:HGNC:18355] GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0043167|GO:0043227|GO:0031224|GO:0005622|GO:0016740|GO:0043231|GO:0043169|GO:0016746|GO:0005737|GO:0016021|GO:0046872|GO:0046912|GO:0005739|GO:0000287|GO:0004474 cell|membrane|metabolic process|binding|catalytic activity|intracellular organelle|ion binding|membrane-bounded organelle|intrinsic component of membrane|intracellular|transferase activity|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|cytoplasm|integral component of membrane|metal ion binding|transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer|mitochondrion|magnesium ion binding|malate synthase activity - - - - 13:99606669-99897134 10 6 6 45 40 56 0.0835107000568655 0.0455400014727765 0.0451792576127841 0.336722808735477 0.274089851291881 0.438311140307559 0.0580766530474754 0.349707933444972 -2.59012030681537 7.63388714498246e-09 1.44333164551176e-07 DOWN ENSG00000071894 CPSF1 cleavage and polyadenylation specific factor 1 [Source:HGNC Symbol;Acc:HGNC:2324] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0071166|GO:0034641|GO:0046483|GO:0043231|GO:0019899|GO:0005849|GO:0006139|GO:0051649|GO:0006403|GO:0044249|GO:0034645|GO:0003723|GO:0046907|GO:0031981|GO:0005654|GO:0050658|GO:0010467|GO:0009059|GO:0005847|GO:0016070|GO:0005634|GO:0043631|GO:0090501|GO:0051028|GO:0051169|GO:0006396|GO:0017091|GO:0032774|GO:0034660|GO:0016071|GO:0044822|GO:0090305|GO:0006406|GO:0006405|GO:0006351|GO:0006378|GO:0006366|GO:0006913|GO:0003729|GO:0006399|GO:0035925|GO:0006397|GO:0006379|GO:0008380|GO:0006353|GO:0031123|GO:0008033|GO:0000375|GO:0051168|GO:0031124|GO:0003730|GO:0006369|GO:0000398|GO:0098789 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|ribonucleoprotein complex localization|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|mRNA cleavage factor complex|nucleobase-containing compound metabolic process|establishment of localization in cell|RNA localization|cellular biosynthetic process|cellular macromolecule biosynthetic process|RNA binding|intracellular transport|nuclear lumen|nucleoplasm|RNA transport|gene expression|macromolecule biosynthetic process|mRNA cleavage and polyadenylation specificity factor complex|RNA metabolic process|nucleus|RNA polyadenylation|RNA phosphodiester bond hydrolysis|mRNA transport|nuclear transport|RNA processing|AU-rich element binding|RNA biosynthetic process|ncRNA metabolic process|mRNA metabolic process|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|mRNA export from nucleus|RNA export from nucleus|transcription, DNA-templated|mRNA polyadenylation|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|mRNA binding|tRNA metabolic process|mRNA 3'-UTR AU-rich region binding|mRNA processing|mRNA cleavage|RNA splicing|DNA-templated transcription, termination|RNA 3'-end processing|tRNA processing|RNA splicing, via transesterification reactions|nuclear export|mRNA 3'-end processing|mRNA 3'-UTR binding|termination of RNA polymerase II transcription|mRNA splicing, via spliceosome|pre-mRNA cleavage required for polyadenylation K14401 cleavage and polyadenylation specificity factor subunit 1[-] - - 8:144393229-144409349 702 822 1000 1847 2265 1995 5.08262848749471 5.40882529767767 6.52777720449028 11.9816265603667 13.4551101249386 13.5370219019081 5.67307699655422 12.9912528624045 -1.19533721954129 7.75200442588757e-09 1.46473632993954e-07 DOWN ENSG00000059122 FLYWCH1 FLYWCH-type zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:25404] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0043169|GO:0005737|GO:0003677|GO:0046872|GO:0031981|GO:0005654|GO:0005634 cell|binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|DNA binding|metal ion binding|nuclear lumen|nucleoplasm|nucleus - - - - 16:2911937-2951208 1571 1862 1869 682 958 943 5.86332659083289 6.31578847776999 6.28914026187985 2.28060289975119 2.93360248555375 3.29843746375153 6.15608511016091 2.83754761635216 1.1173685753978 7.83820076245246e-09 1.48008630969169e-07 UP ENSG00000251349 MSANTD3-TMEFF1 MSANTD3-TMEFF1 readthrough [Source:HGNC Symbol;Acc:HGNC:38838] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 9:100442271-100577636 0 9 14 64 60 53 0 0.279659808298451 0.431557625883997 1.96048638492669 1.68307515707534 1.69819603940139 0.237072478060816 1.78058586046781 -2.90895191063534 7.923914797624e-09 1.49532586832027e-07 DOWN ENSG00000139645 ANKRD52 ankyrin repeat domain 52 [Source:HGNC Symbol;Acc:HGNC:26614] GO:0005488|GO:0005515 binding|protein binding - - - - 12:56237807-56258391 2376 2950 2847 843 989 1549 17.5110194162128 19.7590940331859 18.9176295348724 5.56660047702838 5.98038887125224 10.6990544025223 18.7292476614237 7.41534791693431 1.33670666040901 7.95095814232116e-09 1.49948139217218e-07 UP ENSG00000119729 RHOQ ras homolog family member Q [Source:HGNC Symbol;Acc:HGNC:17736] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0044089|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:1903828|GO:0009893|GO:0016787|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0060341|GO:0008360|GO:0006725|GO:0006810|GO:0051130|GO:0030660|GO:1901360|GO:0005884|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0031982|GO:0051491|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0016817|GO:0022607|GO:0043231|GO:0010243|GO:0005737|GO:0032970|GO:0032880|GO:0012506|GO:0009966|GO:0045184|GO:0010828|GO:0019904|GO:0010646|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0061024|GO:0090005|GO:0060491|GO:0007165|GO:0070062|GO:0009725|GO:0005522|GO:0000166|GO:0030030|GO:0048869|GO:0030029|GO:0044249|GO:0010033|GO:0098857|GO:0031323|GO:0010256|GO:0005794|GO:0006996|GO:0000902|GO:0005829|GO:0005798|GO:0031344|GO:0046326|GO:0010468|GO:0034645|GO:0090150|GO:0007166|GO:0032956|GO:0035639|GO:0007010|GO:0031410|GO:0019693|GO:0051252|GO:0001883|GO:0015031|GO:1901652|GO:0031346|GO:0071417|GO:0010628|GO:0007009|GO:0016023|GO:0016818|GO:0009116|GO:0070201|GO:0032549|GO:0072657|GO:0043434|GO:0030031|GO:0031988|GO:0022604|GO:0030036|GO:0034613|GO:0006796|GO:0035556|GO:0030659|GO:0033043|GO:0010467|GO:0071310|GO:0000139|GO:0017076|GO:0032427|GO:0031328|GO:0009059|GO:0045121|GO:1903827|GO:1902531|GO:0016070|GO:0008643|GO:0032870|GO:0005856|GO:0010557|GO:1903077|GO:0010827|GO:0051489|GO:0015629|GO:0090003|GO:0032561|GO:0045893|GO:0009259|GO:1901653|GO:0009117|GO:0072659|GO:0030866|GO:0090002|GO:0032774|GO:2001141|GO:0046324|GO:0051493|GO:0007167|GO:0046847|GO:0030865|GO:0071375|GO:0006163|GO:0032868|GO:1903076|GO:0005525|GO:0051056|GO:0007264|GO:0019001|GO:1990778|GO:0016462|GO:0042278|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0008645|GO:0006357|GO:1903506|GO:0017111|GO:0032869|GO:0007169|GO:0015758|GO:0003924|GO:0046039|GO:0008286|GO:0046323 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of cellular protein localization|positive regulation of metabolic process|hydrolase activity|biosynthetic process|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cellular localization|regulation of cell shape|cellular aromatic compound metabolic process|transport|positive regulation of cellular component organization|Golgi-associated vesicle membrane|organic cyclic compound metabolic process|actin filament|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|vesicle|positive regulation of filopodium assembly|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|regulation of protein localization|vesicle membrane|regulation of signal transduction|establishment of protein localization|positive regulation of glucose transport|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|membrane organization|negative regulation of establishment of protein localization to plasma membrane|regulation of cell projection assembly|signal transduction|extracellular exosome|response to hormone|profilin binding|nucleotide binding|cell projection organization|cellular developmental process|actin filament-based process|cellular biosynthetic process|response to organic substance|membrane microdomain|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|cell morphogenesis|cytosol|Golgi-associated vesicle|regulation of cell projection organization|positive regulation of glucose import|regulation of gene expression|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|purine ribonucleoside triphosphate binding|cytoskeleton organization|cytoplasmic vesicle|ribose phosphate metabolic process|regulation of RNA metabolic process|purine nucleoside binding|protein transport|response to peptide|positive regulation of cell projection organization|cellular response to organonitrogen compound|positive regulation of gene expression|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nucleoside metabolic process|regulation of establishment of protein localization|ribonucleoside binding|protein localization to membrane|response to peptide hormone|cell projection assembly|membrane-bounded vesicle|regulation of cell morphogenesis|actin cytoskeleton organization|cellular protein localization|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic vesicle membrane|regulation of organelle organization|gene expression|cellular response to organic substance|Golgi membrane|purine nucleotide binding|GBD domain binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|membrane raft|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|carbohydrate transport|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|negative regulation of protein localization to plasma membrane|regulation of glucose transport|regulation of filopodium assembly|actin cytoskeleton|regulation of establishment of protein localization to plasma membrane|guanyl ribonucleotide binding|positive regulation of transcription, DNA-templated|ribonucleotide metabolic process|cellular response to peptide|nucleotide metabolic process|protein localization to plasma membrane|cortical actin cytoskeleton organization|establishment of protein localization to plasma membrane|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of glucose import|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|filopodium assembly|cortical cytoskeleton organization|cellular response to peptide hormone stimulus|purine nucleotide metabolic process|response to insulin|regulation of protein localization to plasma membrane|GTP binding|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|guanyl nucleotide binding|protein localization to cell periphery|pyrophosphatase activity|purine nucleoside metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|hexose transport|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|cellular response to insulin stimulus|transmembrane receptor protein tyrosine kinase signaling pathway|glucose transport|GTPase activity|GTP metabolic process|insulin receptor signaling pathway|glucose import K07194 Ras homolog gene family, member Q[-] hsa04910 Insulin signaling pathway - Homo sapiens (human) 2:46541806-46583121 81 80 113 215 395 372 0.845714652851868 0.759112054070193 1.06372738077406 2.01127711053566 3.383777751513 3.64005904317768 0.88951802923204 3.01170463507545 -1.75948453624313 7.95701656033678e-09 1.4996765933857e-07 DOWN ENSG00000105136 ZNF419 zinc finger protein 419 [Source:HGNC Symbol;Acc:HGNC:20648] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 19:57487711-57496097 478 607 441 179 254 201 1.36493756466964 1.57526331287958 1.13537138999017 0.457969480318794 0.595093914824918 0.537910835739181 1.3585240891798 0.530324743627631 1.35709217976732 8.03779014411565e-09 1.5139443972393e-07 UP ENSG00000239407 LL0XNC01-237H1.2 - - - - - - - X:102884414-102906158 6 1 1 28 36 25 0.314837817276699 0.047713447134228 0.0472883366616057 1.31646866081552 1.54996012719121 1.22949197677608 0.136613200357511 1.36530692159427 -3.32105650906692 8.06379598834443e-09 1.51788502796995e-07 DOWN ENSG00000105519 CAPS calcyphosine [Source:HGNC Symbol;Acc:HGNC:1487] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0009056|GO:0043167|GO:0006914|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0031982|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0000422|GO:0070062|GO:0016236|GO:0006996|GO:1903008|GO:0046872|GO:0000423|GO:0007005|GO:0035556|GO:0005634|GO:0005509|GO:0098779 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|catabolic process|ion binding|autophagy|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|vesicle|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell communication|signal transduction|mitophagy|extracellular exosome|macroautophagy|organelle organization|organelle disassembly|metal ion binding|macromitophagy|mitochondrion organization|intracellular signal transduction|nucleus|calcium ion binding|mitophagy in response to mitochondrial depolarization - - - - 19:5911707-5916208 122 115 231 466 474 594 1.18819940043639 1.0179086002686 2.02841290035733 4.06642591537825 3.78770661156556 5.42181865990537 1.41150696702077 4.42531706228306 -1.64854457442281 8.24369360203036e-09 1.55077018774426e-07 DOWN ENSG00000157483 MYO1E myosin IE [Source:HGNC Symbol;Acc:HGNC:7599] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0043167|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0008289|GO:0016787|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048514|GO:0005903|GO:0003014|GO:0009791|GO:0048569|GO:0001822|GO:0009888|GO:0048468|GO:0006810|GO:0001568|GO:0032835|GO:0007275|GO:0048513|GO:0043168|GO:0043062|GO:0005912|GO:0005543|GO:0001882|GO:0031982|GO:0032836|GO:0016817|GO:0043231|GO:0005737|GO:0006928|GO:0032403|GO:0072006|GO:0016459|GO:0005516|GO:0007154|GO:0007165|GO:0070062|GO:0008092|GO:0000166|GO:0048869|GO:0030029|GO:0016192|GO:0007166|GO:0035639|GO:0001944|GO:0097205|GO:0035166|GO:0030097|GO:0072358|GO:0061005|GO:0031410|GO:0001655|GO:0002064|GO:0035091|GO:0030048|GO:0001883|GO:0003779|GO:0009790|GO:0016023|GO:0016818|GO:0072001|GO:0032549|GO:0001570|GO:0031988|GO:0051015|GO:0060429|GO:0072073|GO:0017076|GO:0030198|GO:0030154|GO:0072359|GO:0005856|GO:0015629|GO:0009792|GO:0030139|GO:0030855|GO:0005524|GO:0030554|GO:0007167|GO:0030135|GO:0006897|GO:0003094|GO:0016462|GO:0030136|GO:0072112|GO:0017111|GO:0072015|GO:0043009|GO:0045334|GO:0007169|GO:0016887|GO:0048008|GO:0001701|GO:0003774|GO:0000146|GO:0042623 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|ion binding|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|lipid binding|hydrolase activity|intracellular|immune system development|protein binding|protein complex|anatomical structure development|blood vessel morphogenesis|brush border|renal system process|post-embryonic development|post-embryonic organ development|kidney development|tissue development|cell development|transport|blood vessel development|glomerulus development|multicellular organism development|animal organ development|anion binding|extracellular structure organization|adherens junction|phospholipid binding|nucleoside binding|vesicle|glomerular basement membrane development|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|protein complex binding|nephron development|myosin complex|calmodulin binding|cell communication|signal transduction|extracellular exosome|cytoskeletal protein binding|nucleotide binding|cellular developmental process|actin filament-based process|vesicle-mediated transport|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|vasculature development|renal filtration|post-embryonic hemopoiesis|hemopoiesis|cardiovascular system development|cell differentiation involved in kidney development|cytoplasmic vesicle|urogenital system development|epithelial cell development|phosphatidylinositol binding|actin filament-based movement|purine nucleoside binding|actin binding|embryo development|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|renal system development|ribonucleoside binding|vasculogenesis|membrane-bounded vesicle|actin filament binding|epithelium development|kidney epithelium development|purine nucleotide binding|extracellular matrix organization|cell differentiation|circulatory system development|cytoskeleton|actin cytoskeleton|embryo development ending in birth or egg hatching|endocytic vesicle|epithelial cell differentiation|ATP binding|adenyl nucleotide binding|enzyme linked receptor protein signaling pathway|coated vesicle|endocytosis|glomerular filtration|pyrophosphatase activity|clathrin-coated vesicle|glomerular visceral epithelial cell differentiation|nucleoside-triphosphatase activity|glomerular visceral epithelial cell development|chordate embryonic development|clathrin-coated endocytic vesicle|transmembrane receptor protein tyrosine kinase signaling pathway|ATPase activity|platelet-derived growth factor receptor signaling pathway|in utero embryonic development|motor activity|microfilament motor activity|ATPase activity, coupled - - - - 15:59132434-59372900 432 490 917 1762 1868 1599 2.80815021811562 2.89476556405622 5.37428522725852 10.2622017385345 9.96281211557426 9.74124559132487 3.69240033647679 9.98875314847788 -1.43574562309296 8.2598130438138e-09 1.55282404666258e-07 DOWN ENSG00000248569 CTC-512J14.5 - - - - - - - 5:80351021-80351956 16 15 29 120 120 64 1.20919152576874 1.03027773060247 1.9759937326152 8.12547632475639 7.44077457262582 4.5329613655739 1.40515432966214 6.69973742098537 -2.25337596200013 8.37726415248887e-09 1.57391342988296e-07 DOWN ENSG00000121966 CXCR4 chemokine (C-X-C motif) receptor 4 [Source:HGNC Symbol;Acc:HGNC:2561] GO:0040011|GO:0032502|GO:0004871|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0004872|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006950|GO:0071704|GO:0050900|GO:0008144|GO:0009628|GO:0009986|GO:0044237|GO:0050795|GO:0038023|GO:0048870|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0031252|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0016032|GO:0036336|GO:0032182|GO:0006935|GO:0045595|GO:0009888|GO:0048468|GO:0006810|GO:0010941|GO:0007275|GO:0048513|GO:0006952|GO:0030900|GO:0001618|GO:0031982|GO:0031325|GO:0007420|GO:0045597|GO:0043231|GO:0019899|GO:0004888|GO:0005737|GO:0003012|GO:0060322|GO:0050920|GO:0006928|GO:0042592|GO:0009615|GO:0001775|GO:0009966|GO:0019725|GO:0008037|GO:0010646|GO:0043085|GO:0007154|GO:0061024|GO:0016477|GO:0007165|GO:0070062|GO:0019955|GO:0008092|GO:0008219|GO:0001666|GO:0030595|GO:0050790|GO:0015026|GO:0048869|GO:0016021|GO:0021537|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0010256|GO:0003013|GO:0005768|GO:0051701|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0022029|GO:0007186|GO:0006936|GO:0007166|GO:0043412|GO:0004896|GO:0034097|GO:0007417|GO:0031410|GO:0010720|GO:0005769|GO:0043130|GO:0002064|GO:0048878|GO:0017022|GO:0003779|GO:0005773|GO:0007009|GO:0016023|GO:0051347|GO:0021885|GO:0036211|GO:0001764|GO:0006811|GO:0006954|GO:0055082|GO:0005770|GO:0060326|GO:0050769|GO:0051247|GO:0031988|GO:0008038|GO:0043269|GO:0032270|GO:0012501|GO:0002407|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0007399|GO:0019058|GO:0071310|GO:0051246|GO:0030154|GO:0008528|GO:1902531|GO:0008015|GO:0004930|GO:0043067|GO:0051960|GO:0008366|GO:0044389|GO:0048666|GO:0006941|GO:0030182|GO:0031625|GO:0019221|GO:0031401|GO:0042119|GO:0043217|GO:0010001|GO:0030855|GO:0043408|GO:0000323|GO:0046718|GO:0060047|GO:0006812|GO:0016310|GO:0043410|GO:0014015|GO:0048709|GO:0071345|GO:0050801|GO:0004950|GO:0042552|GO:0022008|GO:0030260|GO:0006464|GO:0019932|GO:0050767|GO:0043549|GO:0006915|GO:0006873|GO:0032027|GO:0033674|GO:0045859|GO:0045860|GO:0043406|GO:0005764|GO:0006468|GO:0048699|GO:0014013|GO:0045685|GO:0043405|GO:0060048|GO:0042325|GO:0016494|GO:0001932|GO:0045687|GO:0042063|GO:0030001|GO:0001934|GO:0019722|GO:0051924|GO:0070098|GO:0048714|GO:0030003|GO:0048713|GO:0042327|GO:0000187|GO:0055065|GO:0071902|GO:0006875|GO:0071900|GO:0032147|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0007204 locomotion|developmental process|signal transducer activity|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|receptor activity|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|response to stress|organic substance metabolic process|leukocyte migration|drug binding|response to abiotic stimulus|cell surface|cellular metabolic process|regulation of behavior|signaling receptor activity|cell motility|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|cell leading edge|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|viral process|dendritic cell migration|ubiquitin-like protein binding|chemotaxis|regulation of cell differentiation|tissue development|cell development|transport|regulation of cell death|multicellular organism development|animal organ development|defense response|forebrain development|virus receptor activity|vesicle|positive regulation of cellular metabolic process|brain development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|transmembrane signaling receptor activity|cytoplasm|muscle system process|head development|regulation of chemotaxis|movement of cell or subcellular component|homeostatic process|response to virus|cell activation|regulation of signal transduction|cellular homeostasis|cell recognition|regulation of cell communication|positive regulation of catalytic activity|cell communication|membrane organization|cell migration|signal transduction|extracellular exosome|cytokine binding|cytoskeletal protein binding|cell death|response to hypoxia|leukocyte chemotaxis|regulation of catalytic activity|coreceptor activity|cellular developmental process|integral component of membrane|telencephalon development|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|circulatory system process|endosome|interaction with host|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|telencephalon cell migration|G-protein coupled receptor signaling pathway|muscle contraction|cell surface receptor signaling pathway|macromolecule modification|cytokine receptor activity|response to cytokine|central nervous system development|cytoplasmic vesicle|positive regulation of cell development|early endosome|ubiquitin binding|epithelial cell development|chemical homeostasis|myosin binding|actin binding|vacuole|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|forebrain cell migration|protein modification process|neuron migration|ion transport|inflammatory response|cellular chemical homeostasis|late endosome|cell chemotaxis|positive regulation of neurogenesis|positive regulation of protein metabolic process|membrane-bounded vesicle|neuron recognition|regulation of ion transport|positive regulation of cellular protein metabolic process|programmed cell death|dendritic cell chemotaxis|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|viral life cycle|cellular response to organic substance|regulation of protein metabolic process|cell differentiation|G-protein coupled peptide receptor activity|regulation of intracellular signal transduction|blood circulation|G-protein coupled receptor activity|regulation of programmed cell death|regulation of nervous system development|axon ensheathment|ubiquitin-like protein ligase binding|neuron development|striated muscle contraction|neuron differentiation|ubiquitin protein ligase binding|cytokine-mediated signaling pathway|positive regulation of protein modification process|neutrophil activation|myelin maintenance|glial cell differentiation|epithelial cell differentiation|regulation of MAPK cascade|lytic vacuole|viral entry into host cell|heart contraction|cation transport|phosphorylation|positive regulation of MAPK cascade|positive regulation of gliogenesis|oligodendrocyte differentiation|cellular response to cytokine stimulus|ion homeostasis|chemokine receptor activity|myelination|neurogenesis|entry into host cell|cellular protein modification process|second-messenger-mediated signaling|regulation of neurogenesis|regulation of kinase activity|apoptotic process|cellular ion homeostasis|myosin light chain binding|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|lysosome|protein phosphorylation|generation of neurons|regulation of gliogenesis|regulation of glial cell differentiation|regulation of MAP kinase activity|cardiac muscle contraction|regulation of phosphorylation|C-X-C chemokine receptor activity|regulation of protein phosphorylation|positive regulation of glial cell differentiation|gliogenesis|metal ion transport|positive regulation of protein phosphorylation|calcium-mediated signaling|regulation of calcium ion transport|chemokine-mediated signaling pathway|positive regulation of oligodendrocyte differentiation|cellular cation homeostasis|regulation of oligodendrocyte differentiation|positive regulation of phosphorylation|activation of MAPK activity|metal ion homeostasis|positive regulation of protein serine/threonine kinase activity|cellular metal ion homeostasis|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04189 C-X-C chemokine receptor type 4[-] hsa05200|hsa04060|hsa04144|hsa04062|hsa04360|hsa04670|hsa04672 Pathways in cancer - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|Intestinal immune network for IgA production - Homo sapiens (human) 2:136114349-136118165 75 61 112 22 19 26 1.04805395780986 0.774704830399271 1.41109078991914 0.275447380311797 0.217845980503997 0.340505912696933 1.07794985937609 0.277933091170909 1.95548055345575 8.41388795520298e-09 1.5798000692744e-07 UP ENSG00000167081 PBX3 pre-B-cell leukemia homeobox 3 [Source:HGNC Symbol;Acc:HGNC:8634] GO:0032502|GO:0032991|GO:0007610|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0044708|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0007626|GO:0048856|GO:0019222|GO:0043576|GO:0007585|GO:0008344|GO:0006725|GO:0048468|GO:0030534|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0007389|GO:0005667|GO:0006139|GO:0003016|GO:0048869|GO:0044249|GO:0021516|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0007417|GO:0002087|GO:0051252|GO:0021510|GO:0010628|GO:0003705|GO:0003002|GO:0044065|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0048666|GO:0030182|GO:0000975|GO:0045893|GO:0001205|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0009952|GO:0022008|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0007386|GO:0035326|GO:0000976|GO:0001012|GO:0007387|GO:0007388|GO:0000977|GO:0001158|GO:0000980 developmental process|macromolecular complex|behavior|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|single-organism behavior|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|locomotory behavior|anatomical structure development|regulation of metabolic process|regulation of respiratory gaseous exchange|respiratory gaseous exchange|adult locomotory behavior|cellular aromatic compound metabolic process|cell development|adult behavior|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|transcription factor complex|nucleobase-containing compound metabolic process|respiratory system process|cellular developmental process|cellular biosynthetic process|dorsal spinal cord development|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|central nervous system development|regulation of respiratory gaseous exchange by neurological system process|regulation of RNA metabolic process|spinal cord development|positive regulation of gene expression|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|regionalization|regulation of respiratory system process|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|neuron development|neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|anterior/posterior pattern specification|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|compartment pattern specification|enhancer binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|anterior compartment pattern formation|posterior compartment specification|RNA polymerase II regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding K15610 pre-B-cell leukemia transcription factor 3[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 9:125747345-125967377 43 51 33 174 152 159 0.489492896547046 0.527628392450984 0.338693650098918 1.77468356039861 1.41966118181396 1.69629438901107 0.451938313032316 1.63021304374121 -1.8508627431465 8.43142988036154e-09 1.58209872814779e-07 DOWN ENSG00000118007 STAG1 stromal antigen 1 [Source:HGNC Symbol;Acc:HGNC:11354] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0003700|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0003682|GO:0006139|GO:0007059|GO:0051301|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0005829|GO:0010468|GO:0034645|GO:1903047|GO:0043412|GO:0051252|GO:0010628|GO:0036211|GO:0000278|GO:0031981|GO:0005654|GO:0005694|GO:0044267|GO:0007067|GO:0010467|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0006464|GO:0006351|GO:0006355|GO:0000775|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0018193|GO:0043687|GO:0032446|GO:0018205|GO:0016925 macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, sequence-specific DNA binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|chromatin binding|nucleobase-containing compound metabolic process|chromosome segregation|cell division|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|mitotic cell cycle process|macromolecule modification|regulation of RNA metabolic process|positive regulation of gene expression|protein modification process|mitotic cell cycle|nuclear lumen|nucleoplasm|chromosome|cellular protein metabolic process|mitotic nuclear division|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|chromosome, centromeric region|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|post-translational protein modification|protein modification by small protein conjugation|peptidyl-lysine modification|protein sumoylation K06671 cohesin complex subunit SA-1/2[-] hsa04110 Cell cycle - Homo sapiens (human) 3:136336233-136752403 343 361 301 926 1013 770 1.77048829960788 1.69350164004684 1.40080947448612 4.28259499776383 4.29018173624235 3.72493001788744 1.62159980471361 4.09923558396454 -1.33793708417819 8.52242748010913e-09 1.59816928386418e-07 DOWN ENSG00000141504 SAT2 spermidine/spermine N1-acetyltransferase family member 2 [Source:HGNC Symbol;Acc:HGNC:23160] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0005622|GO:0016740|GO:0034641|GO:0031982|GO:0016746|GO:0005737|GO:0070062|GO:0009308|GO:0008215|GO:0016747|GO:0046204|GO:0032920|GO:0009447|GO:0032919|GO:0016407|GO:0006576|GO:0016410|GO:0032918|GO:0008080|GO:0006595|GO:0006598|GO:0004145 cell|cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|transferase activity|cellular nitrogen compound metabolic process|vesicle|transferase activity, transferring acyl groups|cytoplasm|extracellular exosome|amine metabolic process|spermine metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|nor-spermidine metabolic process|putrescine acetylation|putrescine catabolic process|spermine acetylation|acetyltransferase activity|cellular biogenic amine metabolic process|N-acyltransferase activity|spermidine acetylation|N-acetyltransferase activity|polyamine metabolic process|polyamine catabolic process|diamine N-acetyltransferase activity K00657 diamine N-acetyltransferase[2.3.1.57] hsa01100|hsa00330 Metabolic pathways - Homo sapiens (human)|Arginine and proline metabolism - Homo sapiens (human) 17:7626234-7627876 687 694 836 350 314 394 5.18858037028896 4.7635541845174 5.69261688595174 2.36841009970613 1.94576202000648 2.78879969742577 5.21491714691937 2.36765727237946 1.13918407146089 8.58141974082097e-09 1.608221625502e-07 UP ENSG00000096717 SIRT1 sirtuin 1 [Source:HGNC Symbol;Acc:HGNC:14929] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0036094|GO:0051716|GO:0032259|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0007623|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0042698|GO:0019953|GO:0044237|GO:0051641|GO:0006914|GO:0003006|GO:0023051|GO:0000989|GO:0045926|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0048037|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0016787|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0022602|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0048609|GO:0019222|GO:0042802|GO:0016032|GO:0048514|GO:0045137|GO:0060341|GO:0008284|GO:0044262|GO:0051726|GO:0042127|GO:0002250|GO:0007049|GO:0044255|GO:0006281|GO:0000791|GO:0010506|GO:0045595|GO:0003712|GO:0006725|GO:0019866|GO:0042393|GO:0008022|GO:0009314|GO:0006810|GO:0051130|GO:1901360|GO:2001022|GO:0001568|GO:0010941|GO:0006082|GO:0009991|GO:0007275|GO:0016570|GO:0003676|GO:0045596|GO:0048513|GO:0005102|GO:0002039|GO:0034641|GO:0043168|GO:0044281|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0001542|GO:0090287|GO:0010942|GO:0032922|GO:1900076|GO:0061061|GO:0043231|GO:0048608|GO:0019213|GO:0043169|GO:0019899|GO:0010243|GO:0005677|GO:0030308|GO:0005737|GO:0010508|GO:0031668|GO:0032880|GO:0009408|GO:0016810|GO:0005975|GO:0071559|GO:0005635|GO:0032403|GO:0042592|GO:0030728|GO:0009966|GO:0031519|GO:0007548|GO:0050673|GO:0090343|GO:0045184|GO:0009890|GO:0019725|GO:0006979|GO:0019904|GO:0060548|GO:0016458|GO:0010646|GO:0090288|GO:0006139|GO:0043085|GO:0050776|GO:0001525|GO:0000790|GO:0008104|GO:0008406|GO:0007154|GO:0044092|GO:0007276|GO:1900078|GO:0006629|GO:0007165|GO:0050778|GO:0009968|GO:0031647|GO:0042180|GO:2000655|GO:0051649|GO:0008134|GO:0009725|GO:0090344|GO:0008219|GO:0060968|GO:0050662|GO:0016236|GO:0001666|GO:0031965|GO:0050790|GO:0000166|GO:0045833|GO:0043086|GO:0048869|GO:2000773|GO:0010035|GO:0009967|GO:0044249|GO:0010876|GO:0009266|GO:0022613|GO:2000774|GO:0019538|GO:0000792|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0042594|GO:0032370|GO:0006996|GO:0051090|GO:0007568|GO:1900034|GO:0006346|GO:0050679|GO:0051276|GO:1902533|GO:0043518|GO:0005730|GO:2001235|GO:0032268|GO:0006109|GO:1902882|GO:1902230|GO:0003677|GO:0010468|GO:0034645|GO:2000772|GO:1901215|GO:0003714|GO:1904251|GO:0046486|GO:0048232|GO:0046872|GO:0090101|GO:0007166|GO:0005720|GO:0033993|GO:0001944|GO:0043412|GO:0008585|GO:0072594|GO:0061458|GO:0072358|GO:0046628|GO:0034097|GO:0030163|GO:0051345|GO:0042542|GO:0010629|GO:0051427|GO:0043069|GO:0031056|GO:2001234|GO:0048878|GO:0051252|GO:0006631|GO:0016571|GO:0006479|GO:0006325|GO:0044321|GO:0032386|GO:0070997|GO:0051223|GO:0016811|GO:0043425|GO:0015031|GO:0044265|GO:1901652|GO:0046545|GO:0042254|GO:0031058|GO:0071417|GO:0016573|GO:0010628|GO:0051055|GO:0001935|GO:0051347|GO:0036211|GO:0045599|GO:0032269|GO:0000278|GO:0071560|GO:0071456|GO:0070201|GO:0046907|GO:0016239|GO:1902235|GO:0055082|GO:0045739|GO:0016241|GO:0035358|GO:0005637|GO:0007569|GO:0070403|GO:0006638|GO:1900407|GO:0031981|GO:2001020|GO:0000012|GO:0000731|GO:0032368|GO:0007346|GO:0043434|GO:1990234|GO:0034599|GO:0006869|GO:0071478|GO:0034605|GO:0005996|GO:0051247|GO:0051346|GO:0070848|GO:0006508|GO:0005654|GO:0006259|GO:0005739|GO:0033143|GO:0043433|GO:0050678|GO:0005694|GO:0033558|GO:0000228|GO:0009267|GO:0019215|GO:1901214|GO:0033144|GO:0002821|GO:0071453|GO:0034613|GO:0010565|GO:0008202|GO:0006342|GO:0019900|GO:0006282|GO:0032270|GO:0012501|GO:0014070|GO:0000302|GO:0051054|GO:0006796|GO:0010212|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0006290|GO:0010467|GO:0017038|GO:0008610|GO:0042595|GO:0019216|GO:0071310|GO:1902532|GO:0031648|GO:0002819|GO:0045598|GO:0046890|GO:0031328|GO:0045922|GO:0051246|GO:0009059|GO:0030154|GO:0009755|GO:0005719|GO:0046626|GO:0035097|GO:0008206|GO:0043068|GO:0007517|GO:0031669|GO:0006289|GO:1903827|GO:1902531|GO:0016070|GO:0072359|GO:0031667|GO:0007292|GO:0034976|GO:0032870|GO:0010557|GO:0016575|GO:0005634|GO:0009416|GO:0035098|GO:0051287|GO:0070914|GO:0090398|GO:0043067|GO:0033553|GO:0006690|GO:0048545|GO:0097305|GO:0006974|GO:1903202|GO:0006606|GO:0030522|GO:0043398|GO:0097190|GO:0061647|GO:0010638|GO:2001252|GO:0043401|GO:0019217|GO:0070059|GO:0051896|GO:0043491|GO:0007283|GO:0031062|GO:0006364|GO:1904589|GO:0033559|GO:0019318|GO:0000720|GO:0044257|GO:0044320|GO:0045814|GO:0032006|GO:0000975|GO:0051097|GO:0045893|GO:0097193|GO:0043124|GO:0045444|GO:0032376|GO:0019221|GO:2001242|GO:0033365|GO:0033157|GO:0051898|GO:0031401|GO:1902176|GO:0006260|GO:0008631|GO:0001678|GO:0006699|GO:0043122|GO:1901797|GO:0043065|GO:2001251|GO:0009411|GO:0010498|GO:1990254|GO:2001244|GO:0051169|GO:0031929|GO:0006396|GO:1901653|GO:0045892|GO:0014068|GO:0045348|GO:0072331|GO:0042770|GO:0032774|GO:0035067|GO:0043565|GO:0035356|GO:0035357|GO:0034660|GO:0019218|GO:0030162|GO:2001141|GO:0035257|GO:0043966|GO:2001243|GO:0043967|GO:0045862|GO:0071363|GO:0016310|GO:0006605|GO:0033044|GO:1902237|GO:1902679|GO:0052547|GO:0060766|GO:0071383|GO:0071407|GO:0007179|GO:0016604|GO:0003690|GO:1902166|GO:0030518|GO:0030512|GO:0016482|GO:0001936|GO:0006694|GO:0006886|GO:0048017|GO:0010906|GO:0040029|GO:0070857|GO:0051603|GO:0007167|GO:0031060|GO:0051567|GO:0018022|GO:0006633|GO:0008630|GO:0007249|GO:0071375|GO:0000183|GO:0071482|GO:0006344|GO:0050810|GO:1901796|GO:0034968|GO:0015918|GO:0042981|GO:0035065|GO:0071345|GO:0032088|GO:0050801|GO:0045342|GO:0043066|GO:0001938|GO:0090335|GO:0045717|GO:0060765|GO:0019752|GO:0016568|GO:0033673|GO:0032868|GO:0055088|GO:0006639|GO:0034612|GO:0071479|GO:0042306|GO:0031937|GO:0033574|GO:0034979|GO:0014066|GO:1900180|GO:0070932|GO:0034614|GO:0019901|GO:0006464|GO:0000060|GO:0046456|GO:0006343|GO:0010952|GO:0004407|GO:0071396|GO:0071897|GO:1902175|GO:0042304|GO:0043549|GO:0017015|GO:0006351|GO:0070301|GO:0006915|GO:0006355|GO:0043516|GO:0090400|GO:0032007|GO:0033500|GO:0033674|GO:0036294|GO:0006636|GO:0032071|GO:0044154|GO:0042593|GO:1903533|GO:2000108|GO:0045944|GO:0033034|GO:0006366|GO:0071441|GO:0006913|GO:0072332|GO:0045859|GO:1903507|GO:0010950|GO:0048015|GO:0010875|GO:0033210|GO:0045860|GO:0051574|GO:0006469|GO:0006357|GO:0043281|GO:0019941|GO:0006468|GO:0042771|GO:0090239|GO:0071356|GO:1903506|GO:0006006|GO:0032374|GO:0044212|GO:0033158|GO:0055090|GO:0017136|GO:0042325|GO:0033028|GO:0033032|GO:0030301|GO:1901984|GO:0001932|GO:0055081|GO:0071394|GO:0032869|GO:0018193|GO:0055089|GO:0051019|GO:0042326|GO:0030521|GO:0016605|GO:0050872|GO:0016072|GO:0043984|GO:0031393|GO:0071440|GO:0032787|GO:0050873|GO:0043280|GO:0001934|GO:0010657|GO:0007178|GO:1990619|GO:0001933|GO:0000122|GO:1902165|GO:1902254|GO:1902253|GO:0090241|GO:0034644|GO:0042327|GO:0055092|GO:0006641|GO:0030330|GO:0006693|GO:0034504|GO:0046822|GO:0051570|GO:0043161|GO:0007169|GO:0006925|GO:0052548|GO:0032446|GO:0006511|GO:0051170|GO:2000111|GO:0001047|GO:2001056|GO:0006642|GO:0000976|GO:0070328|GO:0071901|GO:0071902|GO:0033344|GO:0071888|GO:0001516|GO:2000619|GO:0014065|GO:2000757|GO:0006476|GO:0010874|GO:0071900|GO:2000116|GO:2000109|GO:0006473|GO:0042632|GO:0018205|GO:0046969|GO:0008286|GO:0034391|GO:0018394|GO:0001046|GO:2000480|GO:2000481|GO:0034983|GO:2000479|GO:0016567|GO:0006475|GO:0018393 developmental process|growth|macromolecular complex|reproduction|immune system process|signaling|cell|rhythmic process|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|small molecule binding|cellular response to stimulus|methylation|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|circadian rhythm|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|immune response|response to abiotic stimulus|ovulation cycle|sexual reproduction|cellular metabolic process|cellular localization|autophagy|developmental process involved in reproduction|regulation of signaling|transcription factor activity, transcription factor binding|negative regulation of growth|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|cofactor binding|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|ovulation cycle process|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|identical protein binding|viral process|blood vessel morphogenesis|development of primary sexual characteristics|regulation of cellular localization|positive regulation of cell proliferation|cellular carbohydrate metabolic process|regulation of cell cycle|regulation of cell proliferation|adaptive immune response|cell cycle|cellular lipid metabolic process|DNA repair|euchromatin|regulation of autophagy|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|organelle inner membrane|histone binding|protein C-terminus binding|response to radiation|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|blood vessel development|regulation of cell death|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|histone modification|nucleic acid binding|negative regulation of cell differentiation|animal organ development|receptor binding|p53 binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|ovulation from ovarian follicle|regulation of cellular response to growth factor stimulus|positive regulation of cell death|circadian regulation of gene expression|regulation of cellular response to insulin stimulus|muscle structure development|intracellular membrane-bounded organelle|reproductive structure development|deacetylase activity|cation binding|enzyme binding|response to organonitrogen compound|chromatin silencing complex|negative regulation of cell growth|cytoplasm|positive regulation of autophagy|cellular response to extracellular stimulus|regulation of protein localization|response to heat|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|carbohydrate metabolic process|response to transforming growth factor beta|nuclear envelope|protein complex binding|homeostatic process|ovulation|regulation of signal transduction|PcG protein complex|sex differentiation|epithelial cell proliferation|positive regulation of cell aging|establishment of protein localization|negative regulation of biosynthetic process|cellular homeostasis|response to oxidative stress|protein domain specific binding|negative regulation of cell death|gene silencing|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|angiogenesis|nuclear chromatin|protein localization|gonad development|cell communication|negative regulation of molecular function|gamete generation|positive regulation of cellular response to insulin stimulus|lipid metabolic process|signal transduction|positive regulation of immune response|negative regulation of signal transduction|regulation of protein stability|cellular ketone metabolic process|negative regulation of cellular response to testosterone stimulus|establishment of localization in cell|transcription factor binding|response to hormone|negative regulation of cell aging|cell death|regulation of gene silencing|coenzyme binding|macroautophagy|response to hypoxia|nuclear membrane|regulation of catalytic activity|nucleotide binding|negative regulation of lipid metabolic process|negative regulation of catalytic activity|cellular developmental process|negative regulation of cellular senescence|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|response to temperature stimulus|ribonucleoprotein complex biogenesis|positive regulation of cellular senescence|protein metabolic process|heterochromatin|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to starvation|positive regulation of lipid transport|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|aging|regulation of cellular response to heat|methylation-dependent chromatin silencing|positive regulation of epithelial cell proliferation|chromosome organization|positive regulation of intracellular signal transduction|negative regulation of DNA damage response, signal transduction by p53 class mediator|nucleolus|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|regulation of response to oxidative stress|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of cellular senescence|negative regulation of neuron death|transcription corepressor activity|regulation of bile acid metabolic process|glycerolipid metabolic process|male gamete generation|metal ion binding|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|nuclear heterochromatin|response to lipid|vasculature development|macromolecule modification|female gonad development|establishment of protein localization to organelle|reproductive system development|cardiovascular system development|positive regulation of insulin receptor signaling pathway|response to cytokine|protein catabolic process|positive regulation of hydrolase activity|response to hydrogen peroxide|negative regulation of gene expression|hormone receptor binding|negative regulation of programmed cell death|regulation of histone modification|negative regulation of apoptotic signaling pathway|chemical homeostasis|regulation of RNA metabolic process|fatty acid metabolic process|histone methylation|protein methylation|chromatin organization|response to leptin|regulation of intracellular transport|neuron death|regulation of protein transport|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|bHLH transcription factor binding|protein transport|cellular macromolecule catabolic process|response to peptide|development of primary female sexual characteristics|ribosome biogenesis|positive regulation of histone modification|cellular response to organonitrogen compound|histone acetylation|positive regulation of gene expression|negative regulation of lipid biosynthetic process|endothelial cell proliferation|positive regulation of transferase activity|protein modification process|negative regulation of fat cell differentiation|negative regulation of cellular protein metabolic process|mitotic cell cycle|cellular response to transforming growth factor beta stimulus|cellular response to hypoxia|regulation of establishment of protein localization|intracellular transport|positive regulation of macroautophagy|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|cellular chemical homeostasis|positive regulation of DNA repair|regulation of macroautophagy|regulation of peroxisome proliferator activated receptor signaling pathway|nuclear inner membrane|cell aging|NAD+ binding|neutral lipid metabolic process|regulation of cellular response to oxidative stress|nuclear lumen|regulation of response to DNA damage stimulus|single strand break repair|DNA synthesis involved in DNA repair|regulation of lipid transport|regulation of mitotic cell cycle|response to peptide hormone|transferase complex|cellular response to oxidative stress|lipid transport|cellular response to radiation|cellular response to heat|monosaccharide metabolic process|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|proteolysis|nucleoplasm|DNA metabolic process|mitochondrion|regulation of intracellular steroid hormone receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of epithelial cell proliferation|chromosome|protein deacetylase activity|nuclear chromosome|cellular response to starvation|intermediate filament binding|regulation of neuron death|negative regulation of intracellular steroid hormone receptor signaling pathway|positive regulation of adaptive immune response|cellular response to oxygen levels|cellular protein localization|regulation of cellular ketone metabolic process|steroid metabolic process|chromatin silencing|kinase binding|regulation of DNA repair|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|response to reactive oxygen species|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|response to ionizing radiation|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|pyrimidine dimer repair|gene expression|protein import|lipid biosynthetic process|behavioral response to starvation|regulation of lipid metabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|protein destabilization|regulation of adaptive immune response|regulation of fat cell differentiation|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|negative regulation of fatty acid metabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|nuclear euchromatin|regulation of insulin receptor signaling pathway|histone methyltransferase complex|bile acid metabolic process|positive regulation of programmed cell death|muscle organ development|cellular response to nutrient levels|nucleotide-excision repair|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|response to nutrient levels|female gamete generation|response to endoplasmic reticulum stress|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|response to light stimulus|ESC/E(Z) complex|NAD binding|UV-damage excision repair|cellular senescence|regulation of programmed cell death|rDNA heterochromatin|icosanoid metabolic process|response to steroid hormone|response to alcohol|cellular response to DNA damage stimulus|negative regulation of oxidative stress-induced cell death|protein import into nucleus|intracellular receptor signaling pathway|HLH domain binding|apoptotic signaling pathway|histone H3-K9 modification|positive regulation of organelle organization|positive regulation of chromosome organization|steroid hormone mediated signaling pathway|regulation of fatty acid metabolic process|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|regulation of protein kinase B signaling|protein kinase B signaling|spermatogenesis|positive regulation of histone methylation|rRNA processing|regulation of protein import|unsaturated fatty acid metabolic process|hexose metabolic process|pyrimidine dimer repair by nucleotide-excision repair|cellular protein catabolic process|cellular response to leptin stimulus|negative regulation of gene expression, epigenetic|regulation of TOR signaling|regulatory region DNA binding|negative regulation of helicase activity|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|fat cell differentiation|positive regulation of cholesterol transport|cytokine-mediated signaling pathway|regulation of intrinsic apoptotic signaling pathway|protein localization to organelle|regulation of intracellular protein transport|negative regulation of protein kinase B signaling|positive regulation of protein modification process|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|DNA replication|intrinsic apoptotic signaling pathway in response to oxidative stress|cellular glucose homeostasis|bile acid biosynthetic process|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of signal transduction by p53 class mediator|positive regulation of apoptotic process|negative regulation of chromosome organization|response to UV|proteasomal protein catabolic process|keratin filament binding|positive regulation of intrinsic apoptotic signaling pathway|nuclear transport|TOR signaling|RNA processing|cellular response to peptide|negative regulation of transcription, DNA-templated|positive regulation of phosphatidylinositol 3-kinase signaling|positive regulation of MHC class II biosynthetic process|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|negative regulation of histone acetylation|sequence-specific DNA binding|cellular triglyceride homeostasis|peroxisome proliferator activated receptor signaling pathway|ncRNA metabolic process|regulation of steroid metabolic process|regulation of proteolysis|regulation of RNA biosynthetic process|nuclear hormone receptor binding|histone H3 acetylation|negative regulation of intrinsic apoptotic signaling pathway|histone H4 acetylation|positive regulation of proteolysis|cellular response to growth factor stimulus|phosphorylation|protein targeting|regulation of chromosome organization|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of RNA biosynthetic process|regulation of peptidase activity|negative regulation of androgen receptor signaling pathway|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|transforming growth factor beta receptor signaling pathway|nuclear body|double-stranded DNA binding|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|intracellular steroid hormone receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|cytosolic transport|regulation of endothelial cell proliferation|steroid biosynthetic process|intracellular protein transport|inositol lipid-mediated signaling|regulation of glucose metabolic process|regulation of gene expression, epigenetic|regulation of bile acid biosynthetic process|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|regulation of histone methylation|histone H3-K9 methylation|peptidyl-lysine methylation|fatty acid biosynthetic process|intrinsic apoptotic signaling pathway in response to DNA damage|I-kappaB kinase/NF-kappaB signaling|cellular response to peptide hormone stimulus|chromatin silencing at rDNA|cellular response to light stimulus|maintenance of chromatin silencing|regulation of steroid biosynthetic process|regulation of signal transduction by p53 class mediator|histone lysine methylation|sterol transport|regulation of apoptotic process|regulation of histone acetylation|cellular response to cytokine stimulus|negative regulation of NF-kappaB transcription factor activity|ion homeostasis|MHC class II biosynthetic process|negative regulation of apoptotic process|positive regulation of endothelial cell proliferation|regulation of brown fat cell differentiation|negative regulation of fatty acid biosynthetic process|regulation of androgen receptor signaling pathway|carboxylic acid metabolic process|chromatin modification|negative regulation of kinase activity|response to insulin|lipid homeostasis|acylglycerol metabolic process|response to tumor necrosis factor|cellular response to ionizing radiation|regulation of protein import into nucleus|positive regulation of chromatin silencing|response to testosterone|NAD-dependent protein deacetylase activity|regulation of phosphatidylinositol 3-kinase signaling|regulation of protein localization to nucleus|histone H3 deacetylation|cellular response to reactive oxygen species|protein kinase binding|cellular protein modification process|protein import into nucleus, translocation|icosanoid biosynthetic process|establishment of chromatin silencing|positive regulation of peptidase activity|histone deacetylase activity|cellular response to lipid|DNA biosynthetic process|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|regulation of fatty acid biosynthetic process|regulation of kinase activity|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|cellular response to hydrogen peroxide|apoptotic process|regulation of transcription, DNA-templated|regulation of DNA damage response, signal transduction by p53 class mediator|stress-induced premature senescence|negative regulation of TOR signaling|carbohydrate homeostasis|positive regulation of kinase activity|cellular response to decreased oxygen levels|unsaturated fatty acid biosynthetic process|regulation of endodeoxyribonuclease activity|histone H3-K14 acetylation|glucose homeostasis|regulation of protein targeting|positive regulation of leukocyte apoptotic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of myeloid cell apoptotic process|transcription from RNA polymerase II promoter|negative regulation of histone H3-K14 acetylation|nucleocytoplasmic transport|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of endopeptidase activity|phosphatidylinositol-mediated signaling|positive regulation of cholesterol efflux|leptin-mediated signaling pathway|positive regulation of protein kinase activity|positive regulation of histone H3-K9 methylation|negative regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|regulation of cysteine-type endopeptidase activity involved in apoptotic process|modification-dependent protein catabolic process|protein phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of histone H4 acetylation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|glucose metabolic process|regulation of cholesterol transport|transcription regulatory region DNA binding|regulation of protein import into nucleus, translocation|acylglycerol homeostasis|NAD-dependent histone deacetylase activity|regulation of phosphorylation|myeloid cell apoptotic process|regulation of myeloid cell apoptotic process|cholesterol transport|negative regulation of protein acetylation|regulation of protein phosphorylation|anion homeostasis|cellular response to testosterone stimulus|cellular response to insulin stimulus|peptidyl-amino acid modification|fatty acid homeostasis|mitogen-activated protein kinase binding|negative regulation of phosphorylation|androgen receptor signaling pathway|PML body|white fat cell differentiation|rRNA metabolic process|histone H4-K16 acetylation|negative regulation of prostaglandin biosynthetic process|regulation of histone H3-K14 acetylation|monocarboxylic acid metabolic process|brown fat cell differentiation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|muscle cell apoptotic process|transmembrane receptor protein serine/threonine kinase signaling pathway|histone H3-K9 deacetylation|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of histone H4 acetylation|cellular response to UV|positive regulation of phosphorylation|sterol homeostasis|triglyceride metabolic process|DNA damage response, signal transduction by p53 class mediator|prostaglandin metabolic process|protein localization to nucleus|regulation of nucleocytoplasmic transport|regulation of histone H3-K9 methylation|proteasome-mediated ubiquitin-dependent protein catabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|inflammatory cell apoptotic process|regulation of endopeptidase activity|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|nuclear import|positive regulation of macrophage apoptotic process|core promoter binding|positive regulation of cysteine-type endopeptidase activity|triglyceride mobilization|transcription regulatory region sequence-specific DNA binding|triglyceride homeostasis|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|cholesterol efflux|macrophage apoptotic process|prostaglandin biosynthetic process|negative regulation of histone H4-K16 acetylation|phosphatidylinositol 3-kinase signaling|negative regulation of peptidyl-lysine acetylation|protein deacetylation|regulation of cholesterol efflux|regulation of protein serine/threonine kinase activity|regulation of cysteine-type endopeptidase activity|regulation of macrophage apoptotic process|protein acetylation|cholesterol homeostasis|peptidyl-lysine modification|NAD-dependent histone deacetylase activity (H3-K9 specific)|insulin receptor signaling pathway|regulation of smooth muscle cell apoptotic process|peptidyl-lysine acetylation|core promoter sequence-specific DNA binding|negative regulation of cAMP-dependent protein kinase activity|positive regulation of cAMP-dependent protein kinase activity|peptidyl-lysine deacetylation|regulation of cAMP-dependent protein kinase activity|protein ubiquitination|internal protein amino acid acetylation|internal peptidyl-lysine acetylation K11411 NAD-dependent deacetylase sirtuin 1 [EC:3.5.1.-][-] hsa05206|hsa04068|hsa04152|hsa04922|hsa04211|hsa05031|hsa04213 MicroRNAs in cancer - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human) 10:67884669-67918390 1358 1424 1410 661 811 635 10.2246533227445 9.74403830327051 9.57155051867858 4.45910600461381 5.00999841392051 4.48075966696446 9.84674738156453 4.64995469516626 1.08243058624072 8.59554698239536e-09 1.60985859229881e-07 UP ENSG00000183032 SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 [Source:HGNC Symbol;Acc:HGNC:14411] GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0003735|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0006810|GO:0006082|GO:0034641|GO:0044281|GO:0043231|GO:0005737|GO:0006520|GO:0031966|GO:0055085|GO:0016021|GO:0044249|GO:0019538|GO:0005740|GO:0034645|GO:0006518|GO:0005743|GO:0009063|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0043043|GO:0046395|GO:0006412|GO:0019752|GO:0006554 structural molecule activity|cell|membrane|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|transport|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|mitochondrial membrane|transmembrane transport|integral component of membrane|cellular biosynthetic process|protein metabolic process|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|mitochondrial inner membrane|cellular amino acid catabolic process|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|peptide biosynthetic process|carboxylic acid catabolic process|translation|carboxylic acid metabolic process|lysine catabolic process - - - - 14:36677921-37172866 4 2 4 28 34 25 0.0398723579189206 0.0181193072376182 0.0359515512946525 0.2500845201211 0.278083133826661 0.233561891867835 0.0313144054837304 0.253909848605199 -3.01941796085766 8.63879817529551e-09 1.61694470674152e-07 DOWN ENSG00000106069 CHN2 chimerin 2 [Source:HGNC Symbol;Acc:HGNC:1944] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0050794|GO:0043167|GO:0023051|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0035591|GO:0008047|GO:0043169|GO:0005737|GO:0009966|GO:0030674|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0009967|GO:0005829|GO:0005096|GO:0046872|GO:0051345|GO:0030695|GO:0035556|GO:1902531|GO:0005070|GO:0043087|GO:0043547|GO:0051056|GO:0007264 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|binding, bridging|cellular response to stimulus|regulation of cellular process|ion binding|regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|signaling adaptor activity|enzyme activator activity|cation binding|cytoplasm|regulation of signal transduction|protein binding, bridging|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|positive regulation of signal transduction|cytosol|GTPase activator activity|metal ion binding|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|regulation of intracellular signal transduction|SH3/SH2 adaptor activity|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 7:29122274-29514328 41 74 102 257 239 354 0.156947980585909 0.257441439139084 0.352029929033149 0.881451058777755 0.750642615602582 1.26998839586715 0.255473116252714 0.967360690082496 -1.92088243065526 8.72584510557422e-09 1.63221415903392e-07 DOWN ENSG00000064199 SPA17 sperm autoantigenic protein 17 [Source:HGNC Symbol;Acc:HGNC:11210] GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0005488|GO:0042995|GO:0044702|GO:0009986|GO:0019953|GO:0071944|GO:0032504|GO:0005622|GO:0005515|GO:0005886|GO:0005929|GO:0048609|GO:0009897|GO:0036126|GO:0031514|GO:0005737|GO:0035686|GO:0006928|GO:0072372|GO:0008037|GO:0035036|GO:0097228|GO:0007276|GO:0009566|GO:0007017|GO:0048232|GO:0007339|GO:0009988|GO:0007338|GO:0007018|GO:0007283|GO:0003341|GO:0003351 reproduction|cell|membrane|cellular process|reproductive process|binding|cell projection|single organism reproductive process|cell surface|sexual reproduction|cell periphery|multicellular organism reproduction|intracellular|protein binding|plasma membrane|cilium|multicellular organismal reproductive process|external side of plasma membrane|sperm flagellum|motile cilium|cytoplasm|sperm fibrous sheath|movement of cell or subcellular component|primary cilium|cell recognition|sperm-egg recognition|sperm principal piece|gamete generation|fertilization|microtubule-based process|male gamete generation|binding of sperm to zona pellucida|cell-cell recognition|single fertilization|microtubule-based movement|spermatogenesis|cilium movement|epithelial cilium movement - - - - 11:124673798-124697518 65 84 81 290 285 196 0.691207682644599 0.811805979350847 0.776586792069971 2.76304962024378 2.48660116290163 1.95334154830006 0.759866818021806 2.40099744381516 -1.6598153831899 8.79931896227462e-09 1.64492716530837e-07 DOWN ENSG00000196968 FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) [Source:HGNC Symbol;Acc:HGNC:19233] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0070062|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0043412|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:0005795|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0008417|GO:0043413|GO:0036065|GO:0031985|GO:0032580|GO:0006464|GO:0046920 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|protein glycosylation|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|extracellular exosome|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|macromolecule modification|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|fucosyltransferase activity|macromolecule glycosylation|fucosylation|Golgi cisterna|Golgi cisterna membrane|cellular protein modification process|alpha-(1->3)-fucosyltransferase activity - - - - 10:73772291-73780251 242 245 394 105 109 123 2.48199468824746 2.28366237987964 3.64330651053614 0.964878223861894 0.917233594794049 1.18228279436209 2.80298785955441 1.02146487100601 1.45632590622097 8.91898222538630e-09 1.6662534127452e-07 UP ENSG00000146143 PRIM2 primase, DNA, polypeptide 2 (58kDa) [Source:HGNC Symbol;Acc:HGNC:9370] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0032993|GO:0005622|GO:0043234|GO:0016740|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0051536|GO:0003676|GO:0034641|GO:0016772|GO:0046483|GO:0043231|GO:0000723|GO:0043169|GO:0042592|GO:1990077|GO:0019725|GO:0006139|GO:0044249|GO:0006996|GO:0051276|GO:0003677|GO:0051539|GO:0034645|GO:0046872|GO:0010833|GO:1903047|GO:0000722|GO:0044770|GO:0033260|GO:0000278|GO:0005657|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0032201|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0006270|GO:0032200|GO:0006260|GO:0032774|GO:0044772|GO:0022616|GO:0006269|GO:0006310|GO:0006271|GO:0003899|GO:0006261|GO:0006312|GO:0000082|GO:0003896 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|protein-DNA complex|intracellular|protein complex|transferase activity|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|iron-sulfur cluster binding|nucleic acid binding|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|telomere maintenance|cation binding|homeostatic process|primosome complex|cellular homeostasis|nucleobase-containing compound metabolic process|cellular biosynthetic process|organelle organization|chromosome organization|DNA binding|4 iron, 4 sulfur cluster binding|cellular macromolecule biosynthetic process|metal ion binding|telomere maintenance via telomere lengthening|mitotic cell cycle process|telomere maintenance via recombination|cell cycle phase transition|nuclear DNA replication|mitotic cell cycle|replication fork|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|telomere maintenance via semi-conservative replication|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|DNA replication initiation|telomere organization|DNA replication|RNA biosynthetic process|mitotic cell cycle phase transition|DNA strand elongation|DNA replication, synthesis of RNA primer|DNA recombination|DNA strand elongation involved in DNA replication|DNA-directed RNA polymerase activity|DNA-dependent DNA replication|mitotic recombination|G1/S transition of mitotic cell cycle|DNA primase activity K02685 DNA primase large subunit [EC:2.7.7.-][-] hsa01100|hsa00230|hsa00240|hsa03030 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|DNA replication - Homo sapiens (human) 6:57314805-57646849 105 114 206 487 480 385 1.3531405619924 1.33517078466277 2.39350427574318 5.62314032957365 5.07529934801603 4.64987888944973 1.69393854079945 5.11610618901314 -1.59466467686389 8.97901774608837e-09 1.67642023634598e-07 DOWN ENSG00000139289 PHLDA1 pleckstrin homology-like domain, family A, member 1 [Source:HGNC Symbol;Acc:HGNC:8933] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0031090|GO:0010941|GO:0007275|GO:0048513|GO:0030900|GO:0031982|GO:0007420|GO:0010942|GO:0043231|GO:0005737|GO:0060322|GO:0012506|GO:0008219|GO:0048869|GO:0044249|GO:0019538|GO:0005730|GO:0034645|GO:0007417|GO:0031410|GO:0016023|GO:0009100|GO:0031981|GO:0031988|GO:0021872|GO:0012501|GO:0030659|GO:1901137|GO:0007399|GO:0009059|GO:0030154|GO:0043068|GO:0005634|GO:0043067|GO:0030182|GO:0021953|GO:0009101|GO:0043065|GO:0042981|GO:0021879|GO:0022008|GO:0006915|GO:0045210|GO:0048699 developmental process|cell|membrane|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|organelle membrane|regulation of cell death|multicellular organism development|animal organ development|forebrain development|vesicle|brain development|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|head development|vesicle membrane|cell death|cellular developmental process|cellular biosynthetic process|protein metabolic process|nucleolus|cellular macromolecule biosynthetic process|central nervous system development|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|nuclear lumen|membrane-bounded vesicle|forebrain generation of neurons|programmed cell death|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|nervous system development|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|nucleus|regulation of programmed cell death|neuron differentiation|central nervous system neuron differentiation|glycoprotein biosynthetic process|positive regulation of apoptotic process|regulation of apoptotic process|forebrain neuron differentiation|neurogenesis|apoptotic process|FasL biosynthetic process|generation of neurons - - - - 12:76025447-76033932 485 609 803 1493 1666 1530 3.28898489340505 3.75333116583369 4.90964185221581 9.07146381847454 9.26963915511428 9.72389549992632 3.98398597048485 9.35499949117171 -1.23152500799889 9.03817342789346e-09 1.68641018447707e-07 DOWN ENSG00000121067 SPOP speckle type POZ protein [Source:HGNC Symbol;Acc:HGNC:11254] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0043231|GO:0019899|GO:0000151|GO:0019538|GO:0030163|GO:0031461|GO:0044265|GO:0031981|GO:1990234|GO:0006508|GO:0005654|GO:0044267|GO:0005634|GO:0044389|GO:0031625|GO:0044257|GO:0010498|GO:0016604|GO:0051603|GO:0031463|GO:0016607|GO:0019941|GO:0043161|GO:0006511 macromolecular complex|cell|cellular process|metabolic process|binding|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|intracellular membrane-bounded organelle|enzyme binding|ubiquitin ligase complex|protein metabolic process|protein catabolic process|cullin-RING ubiquitin ligase complex|cellular macromolecule catabolic process|nuclear lumen|transferase complex|proteolysis|nucleoplasm|cellular protein metabolic process|nucleus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|proteasomal protein catabolic process|nuclear body|proteolysis involved in cellular protein catabolic process|Cul3-RING ubiquitin ligase complex|nuclear speck|modification-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process - - - - 17:49598884-49678234 121 204 168 534 612 397 0.620726072441497 0.951092147663367 0.777028482270862 2.45443622918507 2.57591930129127 1.90867758374233 0.782948900791909 2.31301103807289 -1.56278209264993 9.20170451358031e-09 1.71585063428124e-07 DOWN ENSG00000088451 TGDS TDP-glucose 4,6-dehydratase [Source:HGNC Symbol;Acc:HGNC:20324] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0006807|GO:0016829|GO:0071704|GO:0044237|GO:0048037|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0006139|GO:0050662|GO:0009225|GO:0016836|GO:0008460 cellular process|metabolic process|binding|catalytic activity|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|cellular metabolic process|cofactor binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|coenzyme binding|nucleotide-sugar metabolic process|hydro-lyase activity|dTDP-glucose 4,6-dehydratase activity K01710 dTDP-glucose 4,6-dehydratase[4.2.1.46] hsa01100 Metabolic pathways - Homo sapiens (human) 13:94574051-94596257 73 88 120 301 285 269 1.81759310402576 1.99129974760933 2.69382822757635 6.714876238448 5.82220025893054 6.27705809314292 2.16757369307048 6.27137819684049 -1.53270148128781 9.21837368318374e-09 1.71788594218332e-07 DOWN ENSG00000125352 RNF113A ring finger protein 113A [Source:HGNC Symbol;Acc:HGNC:12974] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|protein binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - X:119870475-119871827 859 870 806 409 409 429 44.9097905859586 41.3377780178168 37.9924426772183 19.1588345309185 17.5444425163251 21.0200895205555 41.4133370936646 19.2411221892664 1.10590251693871 9.35593018385758e-09 1.74243256212654e-07 UP ENSG00000099381 SETD1A SET domain containing 1A [Source:HGNC Symbol;Acc:HGNC:29010] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0032259|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006725|GO:0008013|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0000166|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0008168|GO:0010468|GO:0034645|GO:0003723|GO:0043412|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0044267|GO:0010467|GO:0009059|GO:0035097|GO:0016070|GO:0005634|GO:0048188|GO:0032774|GO:2001141|GO:0016604|GO:0018022|GO:0008276|GO:0034968|GO:0016568|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0016607|GO:0016279|GO:0051568|GO:1903506|GO:0018193|GO:0042054|GO:0018024|GO:0018205|GO:0042800 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|methylation|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|beta-catenin binding|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|macromolecule modification|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|protein modification process|nuclear lumen|transferase complex|nucleoplasm|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|histone methyltransferase complex|RNA metabolic process|nucleus|Set1C/COMPASS complex|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear body|peptidyl-lysine methylation|protein methyltransferase activity|histone lysine methylation|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|nuclear speck|protein-lysine N-methyltransferase activity|histone H3-K4 methylation|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine modification|histone methyltransferase activity (H3-K4 specific) K11422 histone-lysine N-methyltransferase SETD1[2.1.1.43] hsa00310 Lysine degradation - Homo sapiens (human) 16:30957294-30985116 1573 1864 1492 810 839 761 15.5078879445229 16.7012841286875 13.2619350369349 7.15494904805727 6.78662132612653 7.03133083484037 15.1570357033818 6.99096706967472 1.11642368545989 9.41029263492249e-09 1.75146431622803e-07 UP ENSG00000101442 ACTR5 ARP5 actin-related protein 5 homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:14671] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0000785|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006281|GO:0006725|GO:0009314|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0070603|GO:0043231|GO:0005737|GO:0006139|GO:0000790|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0006302|GO:0031011|GO:0031981|GO:0071478|GO:0006259|GO:0005694|GO:0000228|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0009416|GO:0070914|GO:0006974|GO:0009411|GO:0032774|GO:2001141|GO:0071482|GO:0006310|GO:0006351|GO:0006355|GO:1903506|GO:0034644 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|chromatin|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nuclear chromatin|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|double-strand break repair|Ino80 complex|nuclear lumen|cellular response to radiation|DNA metabolic process|chromosome|nuclear chromosome|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|response to light stimulus|UV-damage excision repair|cellular response to DNA damage stimulus|response to UV|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to light stimulus|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|cellular response to UV - - - - 20:38748442-38772520 503 489 395 195 215 161 13.8715811135185 12.2559536613344 9.82132414399272 4.81826490836432 4.86479089480896 4.16114807955955 11.9829529729485 4.61473462757761 1.37666388441444 9.49158075691983e-09 1.7654931583619e-07 UP ENSG00000171174 RBKS ribokinase [Source:HGNC Symbol;Acc:HGNC:30325] GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0005515|GO:0016740|GO:0044262|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0031982|GO:0005975|GO:0070062|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0005996|GO:0016052|GO:0016301|GO:0006796|GO:0017076|GO:0046835|GO:0016773|GO:0019200|GO:0005524|GO:0030554|GO:0016310|GO:0004747|GO:0019323|GO:0006014|GO:0019303 cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|protein binding|transferase activity|cellular carbohydrate metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|carbohydrate metabolic process|extracellular exosome|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|monosaccharide metabolic process|carbohydrate catabolic process|kinase activity|phosphate-containing compound metabolic process|purine nucleotide binding|carbohydrate phosphorylation|phosphotransferase activity, alcohol group as acceptor|carbohydrate kinase activity|ATP binding|adenyl nucleotide binding|phosphorylation|ribokinase activity|pentose catabolic process|D-ribose metabolic process|D-ribose catabolic process K00852 ribokinase[2.7.1.15] hsa01100|hsa00030 Metabolic pathways - Homo sapiens (human)|Pentose phosphate pathway - Homo sapiens (human) 2:27781364-27891098 30 32 39 132 132 103 0.465775493721214 0.45153504533148 0.545941758932168 1.83626340457726 1.68152614667369 1.49874406824183 0.487750765994954 1.67217787316426 -1.7775122745131 9.50113687993607e-09 1.76617023918812e-07 DOWN ENSG00000187608 ISG15 ISG15 ubiquitin-like modifier [Source:HGNC Symbol;Acc:HGNC:4053] GO:0032502|GO:0031386|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0051707|GO:0043227|GO:0002262|GO:0009607|GO:0009605|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0016032|GO:0001818|GO:1903706|GO:0006281|GO:0045648|GO:0045087|GO:0045595|GO:0006725|GO:1901360|GO:0007275|GO:0048513|GO:0034101|GO:0034641|GO:0006952|GO:0046483|GO:0033554|GO:0098542|GO:0001817|GO:0045597|GO:0043231|GO:0045646|GO:0005737|GO:0001816|GO:0042592|GO:0009615|GO:0006139|GO:0009617|GO:0007154|GO:0007165|GO:0048525|GO:0051607|GO:0048869|GO:0044249|GO:0019538|GO:0050792|GO:0010033|GO:0031324|GO:0031323|GO:0032268|GO:0005829|GO:0034340|GO:0034645|GO:0030218|GO:0032479|GO:0007166|GO:0043412|GO:0030097|GO:0034097|GO:0030163|GO:0019985|GO:0044265|GO:0036211|GO:0032269|GO:0048872|GO:0031981|GO:0032480|GO:0032606|GO:0006508|GO:0005654|GO:0006259|GO:0006301|GO:0044267|GO:0032609|GO:0019079|GO:0045639|GO:0019058|GO:0071310|GO:0051246|GO:0042742|GO:0009059|GO:0030154|GO:0005634|GO:0006974|GO:0045637|GO:0032649|GO:0044257|GO:0019221|GO:0071357|GO:0045069|GO:0051603|GO:0045071|GO:0071345|GO:0030099|GO:0006464|GO:0071897|GO:0032020|GO:0019941|GO:0060337|GO:0032446|GO:0031396|GO:0031397|GO:0016567 developmental process|protein tag|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|response to other organism|membrane-bounded organelle|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|viral process|negative regulation of cytokine production|regulation of hemopoiesis|DNA repair|positive regulation of erythrocyte differentiation|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|erythrocyte homeostasis|cellular nitrogen compound metabolic process|defense response|heterocycle metabolic process|cellular response to stress|defense response to other organism|regulation of cytokine production|positive regulation of cell differentiation|intracellular membrane-bounded organelle|regulation of erythrocyte differentiation|cytoplasm|cytokine production|homeostatic process|response to virus|nucleobase-containing compound metabolic process|response to bacterium|cell communication|signal transduction|negative regulation of viral process|defense response to virus|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of viral process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|response to type I interferon|cellular macromolecule biosynthetic process|erythrocyte differentiation|regulation of type I interferon production|cell surface receptor signaling pathway|macromolecule modification|hemopoiesis|response to cytokine|protein catabolic process|translesion synthesis|cellular macromolecule catabolic process|protein modification process|negative regulation of cellular protein metabolic process|homeostasis of number of cells|nuclear lumen|negative regulation of type I interferon production|type I interferon production|proteolysis|nucleoplasm|DNA metabolic process|postreplication repair|cellular protein metabolic process|interferon-gamma production|viral genome replication|positive regulation of myeloid cell differentiation|viral life cycle|cellular response to organic substance|regulation of protein metabolic process|defense response to bacterium|macromolecule biosynthetic process|cell differentiation|nucleus|cellular response to DNA damage stimulus|regulation of myeloid cell differentiation|regulation of interferon-gamma production|cellular protein catabolic process|cytokine-mediated signaling pathway|cellular response to type I interferon|regulation of viral genome replication|proteolysis involved in cellular protein catabolic process|negative regulation of viral genome replication|cellular response to cytokine stimulus|myeloid cell differentiation|cellular protein modification process|DNA biosynthetic process|ISG15-protein conjugation|modification-dependent protein catabolic process|type I interferon signaling pathway|protein modification by small protein conjugation|regulation of protein ubiquitination|negative regulation of protein ubiquitination|protein ubiquitination K12159 ubiquitin cross-reactive protein[-] hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) 1:1001138-1014541 396 438 426 199 202 163 13.532278331619 13.6028498357238 13.1249835356081 6.09293376830039 5.66363063511208 5.22024942745202 13.420037234317 5.6589379436215 1.24578545243889 9.5131938648743e-09 1.76731107431212e-07 UP ENSG00000109046 WSB1 WD repeat and SOCS box containing 1 [Source:HGNC Symbol;Acc:HGNC:19221] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0007154|GO:0007165|GO:0019538|GO:0043412|GO:0036211|GO:0035556|GO:0044267|GO:0006464|GO:0032446|GO:0016567 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|cell communication|signal transduction|protein metabolic process|macromolecule modification|protein modification process|intracellular signal transduction|cellular protein metabolic process|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination - - - - 17:27294076-27315926 1166 1268 1415 603 668 695 4.56064017321518 4.50740507242973 4.98996815088703 2.1132065080771 2.14373774276222 2.54765692071037 4.68600446551065 2.26820039051656 1.04681022416751 9.52008418460989e-09 1.76749125153821e-07 UP ENSG00000143850 PLEKHA6 pleckstrin homology domain containing A6 [Source:HGNC Symbol;Acc:HGNC:17053] - - - - - - 1:204218851-204377665 416 501 742 1338 1443 1453 3.01810806834498 3.3033814119253 4.85355006268658 8.69750722752849 8.58964983848042 9.87951968357882 3.72501318098562 9.05555891652924 -1.28155815767512 9.78008091988827e-09 1.81463353500525e-07 DOWN ENSG00000140743 CDR2 cerebellar degeneration related protein 2 [Source:HGNC Symbol;Acc:HGNC:1799] GO:0005623|GO:0005488|GO:0005622|GO:0005515|GO:0005737 cell|binding|intracellular|protein binding|cytoplasm - - - - 16:22345936-22437165 1501 1705 2126 837 873 968 20.5767469817614 21.2422484821905 26.2768606360978 10.2806221668778 9.81925272363193 12.4365582238715 22.6986187000166 10.8454777047937 1.06551090653016 9.94867768173426e-09 1.8447690901273e-07 UP ENSG00000182108 DEXI Dexi homolog (mouse) [Source:HGNC Symbol;Acc:HGNC:13267] - - - - - - 16:10928891-10942460 737 812 649 327 385 320 17.908984684793 17.932445942123 14.2187751281451 7.11950036455118 7.67595138304802 7.28757064836313 16.686735251687 7.36100746532078 1.18072658044544 9.99199389949243e-09 1.85165106067937e-07 UP ENSG00000115392 FANCL Fanconi anemia complementation group L [Source:HGNC Symbol;Acc:HGNC:20748] GO:0032991|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0006914|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0032504|GO:0016874|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0048609|GO:0042127|GO:0006281|GO:0006725|GO:1901360|GO:0050688|GO:0034641|GO:0006952|GO:0046483|GO:0033554|GO:0098542|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0005635|GO:0009615|GO:0006139|GO:0007276|GO:0016236|GO:0019787|GO:0051607|GO:0043240|GO:0019538|GO:0046872|GO:0098792|GO:0043412|GO:0004842|GO:0036211|GO:0036297|GO:0031981|GO:0005654|GO:0006259|GO:0044267|GO:0005634|GO:0006974|GO:0050691|GO:0044389|GO:0031625|GO:0061630|GO:0002230|GO:0046914|GO:0006464|GO:0008270|GO:0032446|GO:0016567|GO:0006513 macromolecular complex|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|autophagy|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|multicellular organism reproduction|ligase activity|intracellular|regulation of immune system process|protein binding|protein complex|endomembrane system|transferase activity|multicellular organismal reproductive process|regulation of cell proliferation|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of defense response to virus|cellular nitrogen compound metabolic process|defense response|heterocycle metabolic process|cellular response to stress|defense response to other organism|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|nuclear envelope|response to virus|nucleobase-containing compound metabolic process|gamete generation|macroautophagy|ubiquitin-like protein transferase activity|defense response to virus|Fanconi anaemia nuclear complex|protein metabolic process|metal ion binding|xenophagy|macromolecule modification|ubiquitin-protein transferase activity|protein modification process|interstrand cross-link repair|nuclear lumen|nucleoplasm|DNA metabolic process|cellular protein metabolic process|nucleus|cellular response to DNA damage stimulus|regulation of defense response to virus by host|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|ubiquitin protein ligase activity|positive regulation of defense response to virus by host|transition metal ion binding|cellular protein modification process|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination|protein monoubiquitination K10606 E3 ubiquitin-protein ligase FANCL[2.3.2.27] hsa04120|hsa03460 Ubiquitin mediated proteolysis - Homo sapiens (human)|Fanconi anemia pathway - Homo sapiens (human) 2:58159243-58241372 229 281 356 810 805 639 3.82768145464133 4.26861113158705 5.36493047628695 12.130614229634 11.0398700608043 10.0098960426848 4.48707435417178 11.0601267777077 -1.30152092683152 1.00690985841241e-08 1.86478206656601e-07 DOWN ENSG00000069345 DNAJA2 DnaJ heat shock protein family (Hsp40) member A2 [Source:HGNC Symbol;Acc:HGNC:14884] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0006457|GO:0043227|GO:0005622|GO:0005515|GO:0008284|GO:0042127|GO:0009410|GO:0043168|GO:0001882|GO:0031982|GO:0043231|GO:0042026|GO:0051087|GO:0043169|GO:0005737|GO:0009408|GO:0070062|GO:0051082|GO:0006805|GO:0031072|GO:0000166|GO:0001948|GO:0009266|GO:0005829|GO:0046872|GO:0035639|GO:0001883|GO:0032549|GO:0071466|GO:0017076|GO:0005634|GO:0005524|GO:0030554|GO:0018885 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|protein folding|membrane-bounded organelle|intracellular|protein binding|positive regulation of cell proliferation|regulation of cell proliferation|response to xenobiotic stimulus|anion binding|nucleoside binding|vesicle|intracellular membrane-bounded organelle|protein refolding|chaperone binding|cation binding|cytoplasm|response to heat|extracellular exosome|unfolded protein binding|xenobiotic metabolic process|heat shock protein binding|nucleotide binding|glycoprotein binding|response to temperature stimulus|cytosol|metal ion binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|cellular response to xenobiotic stimulus|purine nucleotide binding|nucleus|ATP binding|adenyl nucleotide binding|carbon tetrachloride metabolic process K09503 DnaJ homolog subfamily A member 2[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 16:46955362-46973788 6349 6772 6239 3308 3373 3170 66.2694845045414 64.2399523864985 58.7134357070744 30.9365216792215 28.8863447249036 31.0096187268727 63.0742908660381 30.2774950436659 1.05880622993298 1.02189356624427e-08 1.89135837115043e-07 UP ENSG00000116273 PHF13 PHD finger protein 13 [Source:HGNC Symbol;Acc:HGNC:22983] GO:0005623|GO:0009987|GO:0005488|GO:0044877|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0007049|GO:0042393|GO:0022402|GO:0043231|GO:0043169|GO:0003682|GO:0007059|GO:0051301|GO:0006996|GO:0051276|GO:0000819|GO:0046872|GO:1903047|GO:0006325|GO:0000278|GO:0031981|GO:0005654|GO:0007067|GO:0035064|GO:0005634|GO:0030261|GO:0007076|GO:0000070|GO:0046914|GO:0016568|GO:0071103|GO:0006323|GO:0008270 cell|cellular process|binding|macromolecular complex binding|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|intracellular|protein binding|cell cycle|histone binding|cell cycle process|intracellular membrane-bounded organelle|cation binding|chromatin binding|chromosome segregation|cell division|organelle organization|chromosome organization|sister chromatid segregation|metal ion binding|mitotic cell cycle process|chromatin organization|mitotic cell cycle|nuclear lumen|nucleoplasm|mitotic nuclear division|methylated histone binding|nucleus|chromosome condensation|mitotic chromosome condensation|mitotic sister chromatid segregation|transition metal ion binding|chromatin modification|DNA conformation change|DNA packaging|zinc ion binding - - - - 1:6613685-6624033 1215 1416 1370 689 715 642 19.1884991670973 20.3239431664644 19.5074038382385 9.74948979377944 9.26485964441629 9.5023013631448 19.6732820572667 9.50555026711351 1.04939560921608 1.02396671847722e-08 1.89402121520563e-07 UP ENSG00000219201 RP11-181C21.4 - - - - - - - 1:77810861-77811781 222 278 275 644 698 634 17.0505752930842 19.4048533962881 19.0429212104201 44.3169626453296 43.9854922126483 45.6356691919147 18.4994499665975 44.6460413499642 -1.27104988438099 1.03072132281498e-08 1.90533463599495e-07 DOWN ENSG00000172954 LCLAT1 lysocardiolipin acyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:26756] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0044255|GO:0007275|GO:0044281|GO:0019637|GO:0043231|GO:0016746|GO:0005737|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0008654|GO:0046486|GO:0006638|GO:0016747|GO:0006796|GO:0008610|GO:0006644|GO:0071617|GO:0046474|GO:0006639|GO:0006650|GO:0008374|GO:0006654|GO:0016024|GO:0046473|GO:0046341|GO:0006641|GO:0042171|GO:0019432|GO:0032048|GO:0003841|GO:0035965 developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|cellular lipid metabolic process|multicellular organism development|small molecule metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|phospholipid biosynthetic process|glycerolipid metabolic process|neutral lipid metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|phosphate-containing compound metabolic process|lipid biosynthetic process|phospholipid metabolic process|lysophospholipid acyltransferase activity|glycerophospholipid biosynthetic process|acylglycerol metabolic process|glycerophospholipid metabolic process|O-acyltransferase activity|phosphatidic acid biosynthetic process|CDP-diacylglycerol biosynthetic process|phosphatidic acid metabolic process|CDP-diacylglycerol metabolic process|triglyceride metabolic process|lysophosphatidic acid acyltransferase activity|triglyceride biosynthetic process|cardiolipin metabolic process|1-acylglycerol-3-phosphate O-acyltransferase activity|cardiolipin acyl-chain remodeling K13513 lysocardiolipin and lysophospholipid acyltransferase [EC:2.3.1.- 2.3.1.51][-] hsa01100|hsa00564|hsa00561 Metabolic pathways - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human) 2:30447226-30644225 151 153 226 497 540 436 0.694355129837461 0.639406334444224 0.936971934026836 2.04766468147293 2.03735296244223 1.87896907878539 0.756911132769507 1.98799557423352 -1.3931187134177 1.04446389411278e-08 1.92954363210662e-07 DOWN ENSG00000112406 HECA hdc homolog, cell cycle regulator [Source:HGNC Symbol;Acc:HGNC:21041] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0048523|GO:0050794|GO:0043229|GO:0043227|GO:0005622|GO:0048856|GO:0051726|GO:0007049|GO:0035295|GO:0007275|GO:0048513|GO:0045786|GO:0043231|GO:0005737|GO:0030323|GO:0000278|GO:0007346|GO:0045930|GO:0005634 developmental process|cell|membrane|cellular process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intracellular|anatomical structure development|regulation of cell cycle|cell cycle|tube development|multicellular organism development|animal organ development|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|respiratory tube development|mitotic cell cycle|regulation of mitotic cell cycle|negative regulation of mitotic cell cycle|nucleus - - - - 6:139135112-139180802 808 847 1332 372 439 529 10.1808637869742 9.69922268167892 15.1318422807177 4.19966294107552 4.53843462318887 6.24679931302775 11.6706429164569 4.99496562576405 1.22433738406322 1.04887995978288e-08 1.93650354479642e-07 UP ENSG00000067992 PDK3 pyruvate dehydrogenase kinase, isozyme 3 [Source:HGNC Symbol;Acc:HGNC:8811] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0044262|GO:0044255|GO:0006082|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0033554|GO:0043231|GO:0005737|GO:0005975|GO:0042592|GO:0072593|GO:0019725|GO:0051186|GO:0007154|GO:0006629|GO:0007165|GO:0042180|GO:0001666|GO:0000166|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0006790|GO:0006109|GO:0009743|GO:0006086|GO:0033993|GO:0035639|GO:0043412|GO:0006637|GO:0048878|GO:0006631|GO:0001883|GO:0097411|GO:0036211|GO:2000377|GO:0071456|GO:0032549|GO:0055082|GO:0005996|GO:0005759|GO:0005739|GO:0016301|GO:0071453|GO:0010565|GO:0070542|GO:0006796|GO:0044267|GO:0051174|GO:0019216|GO:0071310|GO:0017076|GO:0016773|GO:0030522|GO:0019217|GO:0071322|GO:0019318|GO:0071398|GO:0001678|GO:0005524|GO:0035357|GO:0034284|GO:0030554|GO:0016310|GO:0009108|GO:0010906|GO:0010510|GO:0004672|GO:0019752|GO:0006464|GO:0071396|GO:0006084|GO:0033500|GO:0050812|GO:0036294|GO:0071333|GO:0042593|GO:0006468|GO:0006085|GO:0006006|GO:0018193|GO:0004674|GO:0032787|GO:0004740|GO:0009749|GO:0018105|GO:0006090 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular carbohydrate metabolic process|cellular lipid metabolic process|organic acid metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|homeostatic process|reactive oxygen species metabolic process|cellular homeostasis|cofactor metabolic process|cell communication|lipid metabolic process|signal transduction|cellular ketone metabolic process|response to hypoxia|nucleotide binding|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|sulfur compound metabolic process|regulation of carbohydrate metabolic process|response to carbohydrate|acetyl-CoA biosynthetic process from pyruvate|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|acyl-CoA metabolic process|chemical homeostasis|fatty acid metabolic process|purine nucleoside binding|hypoxia-inducible factor-1alpha signaling pathway|protein modification process|regulation of reactive oxygen species metabolic process|cellular response to hypoxia|ribonucleoside binding|cellular chemical homeostasis|monosaccharide metabolic process|mitochondrial matrix|mitochondrion|kinase activity|cellular response to oxygen levels|regulation of cellular ketone metabolic process|response to fatty acid|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of lipid metabolic process|cellular response to organic substance|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|intracellular receptor signaling pathway|regulation of fatty acid metabolic process|cellular response to carbohydrate stimulus|hexose metabolic process|cellular response to fatty acid|cellular glucose homeostasis|ATP binding|peroxisome proliferator activated receptor signaling pathway|response to monosaccharide|adenyl nucleotide binding|phosphorylation|coenzyme biosynthetic process|regulation of glucose metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate|protein kinase activity|carboxylic acid metabolic process|cellular protein modification process|cellular response to lipid|acetyl-CoA metabolic process|carbohydrate homeostasis|regulation of acyl-CoA biosynthetic process|cellular response to decreased oxygen levels|cellular response to glucose stimulus|glucose homeostasis|protein phosphorylation|acetyl-CoA biosynthetic process|glucose metabolic process|peptidyl-amino acid modification|protein serine/threonine kinase activity|monocarboxylic acid metabolic process|pyruvate dehydrogenase (acetyl-transferring) kinase activity|response to glucose|peptidyl-serine phosphorylation|pyruvate metabolic process - - - - X:24465221-24539837 92 113 134 286 342 413 2.06270018889879 2.30253425026711 2.70873493581566 5.74525599474937 6.29130903187174 8.67811986109897 2.35798979166052 6.90489496257336 -1.55006199580268 1.06780463255383e-08 1.9702249382115e-07 DOWN ENSG00000165506 DNAAF2 dynein, axonemal, assembly factor 2 [Source:HGNC Symbol;Acc:HGNC:20188] GO:0040011|GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0006950|GO:0009056|GO:0006914|GO:0048870|GO:0009653|GO:0016043|GO:0051707|GO:0009607|GO:0009605|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0048646|GO:0001539|GO:0050688|GO:0006952|GO:0033554|GO:0022607|GO:0098542|GO:0005737|GO:0006928|GO:0009615|GO:0000422|GO:0016236|GO:0051607|GO:0030030|GO:0048869|GO:0007017|GO:0010033|GO:0006996|GO:0000902|GO:1903008|GO:0098792|GO:0070286|GO:0060285|GO:0033993|GO:0000423|GO:0007010|GO:0007005|GO:0035082|GO:0044782|GO:0030031|GO:0006461|GO:0070925|GO:0032526|GO:0042384|GO:0032990|GO:0048858|GO:0000226|GO:0050691|GO:0060271|GO:0034622|GO:0043623|GO:0002230|GO:0001578|GO:0098779|GO:0071973 locomotion|developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|response to stress|catabolic process|autophagy|cell motility|anatomical structure morphogenesis|cellular component organization|response to other organism|response to biotic stimulus|response to external stimulus|intracellular|regulation of immune system process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|cilium or flagellum-dependent cell motility|regulation of defense response to virus|defense response|cellular response to stress|cellular component assembly|defense response to other organism|cytoplasm|movement of cell or subcellular component|response to virus|mitophagy|macroautophagy|defense response to virus|cell projection organization|cellular developmental process|microtubule-based process|response to organic substance|organelle organization|cell morphogenesis|organelle disassembly|xenophagy|axonemal dynein complex assembly|cilium-dependent cell motility|response to lipid|macromitophagy|cytoskeleton organization|mitochondrion organization|axoneme assembly|cilium organization|cell projection assembly|protein complex assembly|organelle assembly|response to retinoic acid|cilium assembly|cell part morphogenesis|cell projection morphogenesis|microtubule cytoskeleton organization|regulation of defense response to virus by host|cilium morphogenesis|cellular macromolecular complex assembly|cellular protein complex assembly|positive regulation of defense response to virus by host|microtubule bundle formation|mitophagy in response to mitochondrial depolarization|bacterial-type flagellum-dependent cell motility - - - - 14:49625174-49635230 1226 1330 940 520 604 442 29.2687782964337 28.8566430859919 20.2328159516621 11.1228327188489 11.83094090794 9.8892900195654 26.1194124446959 10.9476878821181 1.25449623461456 1.08128649920628e-08 1.99386826110589e-07 UP ENSG00000138182 KIF20B kinesin family member 20B [Source:HGNC Symbol;Acc:HGNC:7212] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0030496|GO:0042995|GO:0097159|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0070938|GO:0043229|GO:0051050|GO:0043167|GO:0051641|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0030427|GO:0043227|GO:0016787|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0042802|GO:0060341|GO:0008284|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:0045595|GO:0035239|GO:0009888|GO:0048468|GO:0006810|GO:0022402|GO:0035295|GO:0007275|GO:0051302|GO:0043168|GO:0005874|GO:0001882|GO:0051128|GO:2000147|GO:0030426|GO:0016817|GO:0045786|GO:0045597|GO:0043231|GO:0005737|GO:0032880|GO:0051222|GO:0006928|GO:0032403|GO:0043005|GO:0021915|GO:0048729|GO:0046983|GO:0048598|GO:0045184|GO:0045787|GO:0019904|GO:0032388|GO:0005875|GO:0008104|GO:0007163|GO:0035148|GO:0051270|GO:0016477|GO:0051649|GO:0008092|GO:0090316|GO:0000166|GO:0030030|GO:0051781|GO:0051301|GO:0048869|GO:2000145|GO:0032878|GO:0007017|GO:0006996|GO:0032467|GO:0005730|GO:0015631|GO:0000902|GO:0031175|GO:0005813|GO:2000114|GO:0090068|GO:0005871|GO:0002009|GO:0035639|GO:1903047|GO:0030424|GO:0010720|GO:0005815|GO:0032386|GO:0001883|GO:0051223|GO:0015031|GO:0007050|GO:0009790|GO:0008017|GO:0030334|GO:0050699|GO:0072175|GO:0016818|GO:0000278|GO:0051233|GO:0070201|GO:0046907|GO:0001764|GO:0032549|GO:0032465|GO:0031981|GO:0016331|GO:0050769|GO:0030010|GO:0007346|GO:0010564|GO:0007018|GO:0048471|GO:0005654|GO:0001841|GO:0034613|GO:0060429|GO:0032506|GO:0033043|GO:0007067|GO:0032990|GO:0007399|GO:0060562|GO:0017076|GO:0030154|GO:0048858|GO:0060606|GO:0030335|GO:1903827|GO:0045931|GO:0005856|GO:0000910|GO:0000922|GO:0005634|GO:0042803|GO:0005819|GO:0051960|GO:0048666|GO:0030182|GO:2001222|GO:0033365|GO:0033157|GO:0009792|GO:0072686|GO:0001843|GO:0007088|GO:0005524|GO:0001838|GO:0030554|GO:1902410|GO:1990023|GO:0006886|GO:2001224|GO:0097431|GO:0015630|GO:0022008|GO:0050767|GO:0048812|GO:0016462|GO:0000281|GO:0048699|GO:0017111|GO:0044380|GO:0043009|GO:1903438|GO:0016887|GO:0003774|GO:0035372|GO:0003777|GO:0008574 locomotion|developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|midbody|cell projection|organic cyclic compound binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|contractile ring|intracellular organelle|positive regulation of transport|ion binding|cellular localization|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|site of polarized growth|membrane-bounded organelle|hydrolase activity|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|identical protein binding|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of cell differentiation|tube morphogenesis|tissue development|cell development|transport|cell cycle process|tube development|multicellular organism development|regulation of cell division|anion binding|microtubule|nucleoside binding|regulation of cellular component organization|positive regulation of cell motility|growth cone|hydrolase activity, acting on acid anhydrides|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|protein complex binding|neuron projection|neural tube development|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|establishment of protein localization|positive regulation of cell cycle|protein domain specific binding|positive regulation of intracellular transport|microtubule associated complex|protein localization|establishment or maintenance of cell polarity|tube formation|regulation of cellular component movement|cell migration|establishment of localization in cell|cytoskeletal protein binding|positive regulation of intracellular protein transport|nucleotide binding|cell projection organization|positive regulation of cell division|cell division|cellular developmental process|regulation of cell motility|regulation of establishment or maintenance of cell polarity|microtubule-based process|organelle organization|positive regulation of cytokinesis|nucleolus|tubulin binding|cell morphogenesis|neuron projection development|centrosome|regulation of establishment of cell polarity|positive regulation of cell cycle process|kinesin complex|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|mitotic cell cycle process|axon|positive regulation of cell development|microtubule organizing center|regulation of intracellular transport|purine nucleoside binding|regulation of protein transport|protein transport|cell cycle arrest|embryo development|microtubule binding|regulation of cell migration|WW domain binding|epithelial tube formation|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|spindle midzone|regulation of establishment of protein localization|intracellular transport|neuron migration|ribonucleoside binding|regulation of cytokinesis|nuclear lumen|morphogenesis of embryonic epithelium|positive regulation of neurogenesis|establishment of cell polarity|regulation of mitotic cell cycle|regulation of cell cycle process|microtubule-based movement|perinuclear region of cytoplasm|nucleoplasm|neural tube formation|cellular protein localization|epithelium development|cytokinetic process|regulation of organelle organization|mitotic nuclear division|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|purine nucleotide binding|cell differentiation|cell projection morphogenesis|tube closure|positive regulation of cell migration|regulation of cellular protein localization|positive regulation of mitotic cell cycle|cytoskeleton|cytokinesis|spindle pole|nucleus|protein homodimerization activity|spindle|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron migration|protein localization to organelle|regulation of intracellular protein transport|embryo development ending in birth or egg hatching|mitotic spindle|neural tube closure|regulation of mitotic nuclear division|ATP binding|embryonic epithelial tube formation|adenyl nucleotide binding|mitotic cytokinetic process|mitotic spindle midzone|intracellular protein transport|positive regulation of neuron migration|mitotic spindle pole|microtubule cytoskeleton|neurogenesis|regulation of neurogenesis|neuron projection morphogenesis|pyrophosphatase activity|mitotic cytokinesis|generation of neurons|nucleoside-triphosphatase activity|protein localization to cytoskeleton|chordate embryonic development|positive regulation of mitotic cytokinetic process|ATPase activity|motor activity|protein localization to microtubule|microtubule motor activity|ATP-dependent microtubule motor activity, plus-end-directed - - - - 10:89701610-89774939 606 819 785 1801 2024 1611 5.87534635074766 7.21647363990289 6.86190641783473 15.6448788915955 16.1004979020163 14.6381214344956 6.65124213616176 15.4611660760358 -1.21695343314194 1.08245127786972e-08 1.99478397836559e-07 DOWN ENSG00000108599 AKAP10 A-kinase anchoring protein 10 [Source:HGNC Symbol;Acc:HGNC:368] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0050817|GO:0043231|GO:0005737|GO:0009611|GO:0008104|GO:0007154|GO:0007165|GO:0050878|GO:0005829|GO:0007596|GO:0042060|GO:0007599|GO:0005739 signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|coagulation|intracellular membrane-bounded organelle|cytoplasm|response to wounding|protein localization|cell communication|signal transduction|regulation of body fluid levels|cytosol|blood coagulation|wound healing|hemostasis|mitochondrion - - - - 17:19904302-19978343 241 262 386 721 740 864 2.25288101908552 2.22588517836873 3.25329200306516 6.03885606360945 5.67572984037414 7.56945641798459 2.57735273350647 6.42801410732273 -1.31848309896523 1.08438035964667e-08 1.99710618487919e-07 DOWN ENSG00000143498 TAF1A TATA-box binding protein associated factor, RNA polymerase I, A [Source:HGNC Symbol;Acc:HGNC:11532] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005667|GO:0009890|GO:0016458|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0044798|GO:0010629|GO:0051252|GO:0006325|GO:0031981|GO:0005654|GO:0006342|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0045814|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0040029|GO:0015630|GO:0000183|GO:0006351|GO:0006355|GO:0000120|GO:0006366|GO:1903507|GO:0006352|GO:0006360|GO:1903506|GO:0006354|GO:0006353|GO:0006361|GO:0006362|GO:0006363 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor complex|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|nuclear transcription factor complex|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|nuclear lumen|nucleoplasm|chromatin silencing|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|microtubule cytoskeleton|chromatin silencing at rDNA|transcription, DNA-templated|regulation of transcription, DNA-templated|RNA polymerase I transcription factor complex|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|transcription from RNA polymerase I promoter|regulation of nucleic acid-templated transcription|DNA-templated transcription, elongation|DNA-templated transcription, termination|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription - - - - 1:222557902-222589933 207 203 222 606 700 468 3.70885087898521 3.30556047282395 3.58620239441438 9.728347091059 10.2904525485483 7.85856313526955 3.53353791540785 9.29245425829228 -1.39494629207364 1.08809843568816e-08 2.00271829217228e-07 DOWN ENSG00000141232 TOB1 transducer of ERBB2, 1 [Source:HGNC Symbol;Acc:HGNC:11979] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0060090|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0023051|GO:0000989|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0035591|GO:0042127|GO:0045595|GO:0003712|GO:0006725|GO:0006810|GO:1901360|GO:0045596|GO:0030279|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0090287|GO:0043231|GO:0046332|GO:0030014|GO:0019899|GO:0005737|GO:0009966|GO:0045184|GO:0009890|GO:0030674|GO:0010646|GO:0090288|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0030278|GO:0009968|GO:0001503|GO:0051649|GO:0008285|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0032268|GO:0010468|GO:0071773|GO:0034645|GO:0003714|GO:0006518|GO:0045668|GO:0090101|GO:0007166|GO:0072594|GO:0030514|GO:0010629|GO:0051252|GO:0045667|GO:0015031|GO:0044265|GO:0010628|GO:0030971|GO:0032269|GO:0046907|GO:0001649|GO:0070848|GO:0034613|GO:0019900|GO:0043603|GO:0044267|GO:0010467|GO:0017038|GO:0071310|GO:0030510|GO:0019439|GO:0051246|GO:0009059|GO:0030154|GO:0016070|GO:0005070|GO:0005634|GO:0006606|GO:0006401|GO:0043043|GO:0033365|GO:0051169|GO:0006396|GO:0050684|GO:0032774|GO:0017148|GO:2001141|GO:0071363|GO:0006605|GO:0010608|GO:1902679|GO:0006412|GO:0006886|GO:0030509|GO:0007167|GO:0016071|GO:0006417|GO:0019901|GO:0007184|GO:0061014|GO:0006351|GO:0006355|GO:0031442|GO:0006366|GO:0006913|GO:1903507|GO:0006357|GO:1903506|GO:0031441|GO:0006402|GO:0031440|GO:0006397|GO:1990782|GO:0007178|GO:1900153|GO:0034504|GO:0031123|GO:0051170|GO:0000956|GO:0031124|GO:0060212|GO:0060213|GO:0000289|GO:0000288 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|binding, bridging|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|regulation of signaling|transcription factor activity, transcription factor binding|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|regulation of metabolic process|signaling adaptor activity|regulation of cell proliferation|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|negative regulation of cell differentiation|negative regulation of ossification|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|intracellular membrane-bounded organelle|SMAD binding|CCR4-NOT complex|enzyme binding|cytoplasm|regulation of signal transduction|establishment of protein localization|negative regulation of biosynthetic process|protein binding, bridging|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|regulation of ossification|negative regulation of signal transduction|ossification|establishment of localization in cell|negative regulation of cell proliferation|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|transcription corepressor activity|peptide metabolic process|negative regulation of osteoblast differentiation|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|establishment of protein localization to organelle|negative regulation of BMP signaling pathway|negative regulation of gene expression|regulation of RNA metabolic process|regulation of osteoblast differentiation|protein transport|cellular macromolecule catabolic process|positive regulation of gene expression|receptor tyrosine kinase binding|negative regulation of cellular protein metabolic process|intracellular transport|osteoblast differentiation|response to growth factor|cellular protein localization|kinase binding|cellular amide metabolic process|cellular protein metabolic process|gene expression|protein import|cellular response to organic substance|regulation of BMP signaling pathway|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|SH3/SH2 adaptor activity|nucleus|protein import into nucleus|RNA catabolic process|peptide biosynthetic process|protein localization to organelle|nuclear transport|RNA processing|regulation of mRNA processing|RNA biosynthetic process|negative regulation of translation|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|protein targeting|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|translation|intracellular protein transport|BMP signaling pathway|enzyme linked receptor protein signaling pathway|mRNA metabolic process|regulation of translation|protein kinase binding|SMAD protein import into nucleus|positive regulation of mRNA catabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of mRNA 3'-end processing|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of mRNA 3'-end processing|mRNA catabolic process|regulation of mRNA 3'-end processing|mRNA processing|protein tyrosine kinase binding|transmembrane receptor protein serine/threonine kinase signaling pathway|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|protein localization to nucleus|RNA 3'-end processing|nuclear import|nuclear-transcribed mRNA catabolic process|mRNA 3'-end processing|negative regulation of nuclear-transcribed mRNA poly(A) tail shortening|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K14443 protein Tob/BTG[-] hsa03018 RNA degradation - Homo sapiens (human) 17:50862223-50867978 3386 3275 2961 1501 1547 1679 52.2388170080484 45.9195612062974 41.1868933387719 20.7484016997057 19.5823437586161 24.2764948322286 46.4484238510392 21.5357467635168 1.10889629134648 1.08903559479207e-08 2.00320817294655e-07 UP ENSG00000093100 XXbac-B461K10.4 - - - - - - - 22:17787652-17811497 0 0 16 165 71 104 0 0 0.23577838076419 2.41624030267132 0.952099675756029 1.59301379858769 0.0785927935880633 1.65378459233835 -4.39523049009796 1.10575386503964e-08 2.0327078748087e-07 DOWN ENSG00000160949 TONSL tonsoku-like, DNA repair protein [Source:HGNC Symbol;Acc:HGNC:7801] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0000989|GO:0043227|GO:1903828|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0060341|GO:0008023|GO:1900181|GO:0006281|GO:0003712|GO:0006725|GO:0042393|GO:0006810|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0051651|GO:0005737|GO:0032880|GO:0045184|GO:0009890|GO:0032387|GO:0006139|GO:0031297|GO:0008104|GO:0051649|GO:0042555|GO:0005662|GO:0090317|GO:0044249|GO:0051224|GO:0031324|GO:0031323|GO:0034645|GO:0035101|GO:0003714|GO:0042308|GO:0000725|GO:0072594|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0006302|GO:0070201|GO:0046907|GO:0005657|GO:0031981|GO:0032507|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0034613|GO:0017038|GO:0009059|GO:1903827|GO:0016070|GO:0005634|GO:0006974|GO:0006606|GO:0051220|GO:1904589|GO:0000724|GO:0033365|GO:0033157|GO:0006260|GO:0043596|GO:0051169|GO:0032774|GO:2001141|GO:0006605|GO:1902679|GO:0016482|GO:0006886|GO:0006310|GO:0042992|GO:0042306|GO:1900180|GO:0042991|GO:1903533|GO:0006913|GO:1903507|GO:0006261|GO:1903506|GO:0042990|GO:0042994|GO:0034504|GO:0046822|GO:0051170 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|transcription factor activity, transcription factor binding|membrane-bounded organelle|negative regulation of cellular protein localization|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cellular localization|transcription elongation factor complex|negative regulation of protein localization to nucleus|DNA repair|transcription cofactor activity|cellular aromatic compound metabolic process|histone binding|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|maintenance of location in cell|cytoplasm|regulation of protein localization|establishment of protein localization|negative regulation of biosynthetic process|negative regulation of intracellular transport|nucleobase-containing compound metabolic process|replication fork processing|protein localization|establishment of localization in cell|MCM complex|DNA replication factor A complex|negative regulation of intracellular protein transport|cellular biosynthetic process|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cellular macromolecule biosynthetic process|FACT complex|transcription corepressor activity|negative regulation of protein import into nucleus|recombinational repair|establishment of protein localization to organelle|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|double-strand break repair|regulation of establishment of protein localization|intracellular transport|replication fork|nuclear lumen|maintenance of protein location in cell|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|cellular protein localization|protein import|macromolecule biosynthetic process|regulation of cellular protein localization|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|protein import into nucleus|cytoplasmic sequestering of protein|regulation of protein import|double-strand break repair via homologous recombination|protein localization to organelle|regulation of intracellular protein transport|DNA replication|nuclear replication fork|nuclear transport|RNA biosynthetic process|regulation of RNA biosynthetic process|protein targeting|negative regulation of RNA biosynthetic process|cytosolic transport|intracellular protein transport|DNA recombination|negative regulation of transcription factor import into nucleus|regulation of protein import into nucleus|regulation of protein localization to nucleus|transcription factor import into nucleus|regulation of protein targeting|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|DNA-dependent DNA replication|regulation of nucleic acid-templated transcription|regulation of transcription factor import into nucleus|cytoplasmic sequestering of transcription factor|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import - - - - 8:144428775-144444444 2776 3051 2442 1230 1557 904 20.0762207090332 20.0532494085637 15.92290474659 7.97012778445076 9.23887597625013 6.127170955296 18.684124954729 7.7787249053323 1.26420740665898 1.10802955667066e-08 2.0356378082982e-07 UP ENSG00000076513 ANKRD13A ankyrin repeat domain 13A [Source:HGNC Symbol;Acc:HGNC:21268] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0043231|GO:0005737|GO:0005768|GO:0005770 cell|membrane|binding|intracellular organelle|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endosome|late endosome - - - - 12:109999186-110039763 161 180 398 725 799 947 0.931811535900123 0.94679384505257 2.07682844142977 3.75957676679431 3.79417991936799 5.13667965543643 1.31847794079415 4.23014544719958 -1.68183383515513 1.10919878744906e-08 2.03653263225733e-07 DOWN ENSG00000068724 TTC7A tetratricopeptide repeat domain 7A [Source:HGNC Symbol;Acc:HGNC:19750] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0005488|GO:0002520|GO:0005515|GO:0048856|GO:0007275|GO:0048513|GO:0042592|GO:0019725|GO:0030097|GO:0048878|GO:0055082|GO:0050801|GO:0006873|GO:0030003|GO:0055065|GO:0006875|GO:0006879|GO:0055072 developmental process|immune system process|cell|cellular process|binding|immune system development|protein binding|anatomical structure development|multicellular organism development|animal organ development|homeostatic process|cellular homeostasis|hemopoiesis|chemical homeostasis|cellular chemical homeostasis|ion homeostasis|cellular ion homeostasis|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|cellular iron ion homeostasis|iron ion homeostasis - - - - 2:46916157-47076137 174 236 453 823 962 916 0.800119372132926 0.98627077232402 1.87809204631367 3.39080013291255 3.62950689568613 3.94756280147131 1.22149406359021 3.65595661002333 -1.58160209598027 1.1130067671411e-08 2.04148551437675e-07 DOWN ENSG00000134852 CLOCK clock circadian regulator [Source:HGNC Symbol;Acc:HGNC:2082] GO:0032502|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0003824|GO:0042752|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0044702|GO:0071704|GO:0009056|GO:0009628|GO:0019953|GO:0044237|GO:0051641|GO:0023051|GO:0000989|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0050793|GO:0005622|GO:0051775|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048609|GO:0019222|GO:0060341|GO:0007049|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0009314|GO:0006810|GO:0022402|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0034641|GO:0032940|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0032922|GO:0043231|GO:0016746|GO:0005737|GO:0000981|GO:0030529|GO:0007267|GO:0009611|GO:0001076|GO:0032880|GO:0005667|GO:0031018|GO:0009966|GO:0046983|GO:0045184|GO:0009890|GO:0046883|GO:0003682|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0007276|GO:0007165|GO:0009968|GO:0009725|GO:0031016|GO:0010817|GO:0048869|GO:0042634|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0009649|GO:0006996|GO:0051090|GO:0035770|GO:0051276|GO:0000982|GO:0003677|GO:0010468|GO:0000075|GO:0034645|GO:0048232|GO:0090276|GO:0033993|GO:0043412|GO:0030163|GO:0010629|GO:0050727|GO:0002064|GO:0051252|GO:0006325|GO:0051223|GO:0015031|GO:0044265|GO:0016573|GO:0010628|GO:0036211|GO:0030856|GO:0070201|GO:0042886|GO:0006954|GO:0051091|GO:0051046|GO:0003309|GO:0035270|GO:0031981|GO:0071478|GO:0009914|GO:0009306|GO:0050729|GO:0006508|GO:0005654|GO:0033143|GO:0016747|GO:0005694|GO:0033144|GO:0014070|GO:0060429|GO:0010212|GO:0044267|GO:0010467|GO:0046903|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0009755|GO:0001191|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0009416|GO:0036464|GO:0048545|GO:0006974|GO:0030522|GO:0042633|GO:0031490|GO:0050796|GO:0003323|GO:0043401|GO:0002790|GO:0007283|GO:0044257|GO:0000975|GO:0045893|GO:0030073|GO:0043566|GO:0010498|GO:0030855|GO:2000323|GO:0045892|GO:0032774|GO:0002066|GO:0043565|GO:2001141|GO:0050708|GO:0015833|GO:0051092|GO:1902679|GO:0000077|GO:0033391|GO:0009648|GO:0071383|GO:0071407|GO:0003690|GO:0030518|GO:0016407|GO:0051603|GO:0016410|GO:2000074|GO:0016568|GO:0071479|GO:0006464|GO:0071396|GO:0046879|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0030072|GO:1903507|GO:0006357|GO:0019941|GO:1903506|GO:0044212|GO:0002068|GO:0001190|GO:0018193|GO:0008080|GO:0043161|GO:0006511|GO:0002067|GO:0001047|GO:0000976|GO:0042921|GO:0001012|GO:0070888|GO:0001159|GO:0006473|GO:0018205|GO:0018394|GO:0001046|GO:0035883|GO:0000977|GO:0000987|GO:0006475|GO:0018393|GO:0004402|GO:0000978 developmental process|macromolecular complex|reproduction|signaling|cell|rhythmic process|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|catalytic activity|regulation of circadian rhythm|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|single organism reproductive process|organic substance metabolic process|catabolic process|response to abiotic stimulus|sexual reproduction|cellular metabolic process|cellular localization|regulation of signaling|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|regulation of developmental process|intracellular|response to redox state|protein binding|protein complex|transferase activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|regulation of cellular localization|cell cycle|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|response to radiation|transport|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|secretion by cell|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|circadian regulation of gene expression|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|intracellular ribonucleoprotein complex|cell-cell signaling|response to wounding|transcription factor activity, RNA polymerase II transcription factor binding|regulation of protein localization|transcription factor complex|endocrine pancreas development|regulation of signal transduction|protein dimerization activity|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|gamete generation|signal transduction|negative regulation of signal transduction|response to hormone|pancreas development|regulation of hormone levels|cellular developmental process|regulation of hair cycle|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|entrainment of circadian clock|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|ribonucleoprotein granule|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|male gamete generation|regulation of peptide hormone secretion|response to lipid|macromolecule modification|protein catabolic process|negative regulation of gene expression|regulation of inflammatory response|epithelial cell development|regulation of RNA metabolic process|chromatin organization|regulation of protein transport|protein transport|cellular macromolecule catabolic process|histone acetylation|positive regulation of gene expression|protein modification process|regulation of epithelial cell differentiation|regulation of establishment of protein localization|amide transport|inflammatory response|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of secretion|type B pancreatic cell differentiation|endocrine system development|nuclear lumen|cellular response to radiation|hormone transport|protein secretion|positive regulation of inflammatory response|proteolysis|nucleoplasm|regulation of intracellular steroid hormone receptor signaling pathway|transferase activity, transferring acyl groups other than amino-acyl groups|chromosome|negative regulation of intracellular steroid hormone receptor signaling pathway|response to organic cyclic compound|epithelium development|response to ionizing radiation|cellular protein metabolic process|gene expression|secretion|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|cytoplasmic ribonucleoprotein granule|response to steroid hormone|cellular response to DNA damage stimulus|intracellular receptor signaling pathway|hair cycle|chromatin DNA binding|regulation of insulin secretion|type B pancreatic cell development|steroid hormone mediated signaling pathway|peptide secretion|spermatogenesis|cellular protein catabolic process|regulatory region DNA binding|positive regulation of transcription, DNA-templated|insulin secretion|structure-specific DNA binding|proteasomal protein catabolic process|epithelial cell differentiation|negative regulation of glucocorticoid receptor signaling pathway|negative regulation of transcription, DNA-templated|RNA biosynthetic process|columnar/cuboidal epithelial cell development|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of protein secretion|peptide transport|positive regulation of NF-kappaB transcription factor activity|negative regulation of RNA biosynthetic process|DNA damage checkpoint|chromatoid body|photoperiodism|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|acetyltransferase activity|proteolysis involved in cellular protein catabolic process|N-acyltransferase activity|regulation of type B pancreatic cell development|chromatin modification|cellular response to ionizing radiation|cellular protein modification process|cellular response to lipid|hormone secretion|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|glandular epithelial cell development|transcriptional activator activity, RNA polymerase II transcription factor binding|peptidyl-amino acid modification|N-acetyltransferase activity|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|glandular epithelial cell differentiation|core promoter binding|transcription regulatory region sequence-specific DNA binding|glucocorticoid receptor signaling pathway|RNA polymerase II regulatory region DNA binding|E-box binding|core promoter proximal region DNA binding|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|core promoter sequence-specific DNA binding|enteroendocrine cell differentiation|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding K02223 circadian locomoter output cycles kaput protein[2.3.1.48] hsa05168|hsa04728|hsa04710 Herpes simplex infection - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Circadian rhythm - Homo sapiens (human) 4:55427903-55547138 130 117 281 590 709 524 0.51175695636679 0.418590058874116 0.997339793353954 2.08099619755087 2.29000184899173 1.93322403118978 0.64256226953162 2.10140735924413 -1.70944768140943 1.11326402405217e-08 2.04148551437675e-07 DOWN ENSG00000137210 TMEM14B transmembrane protein 14B [Source:HGNC Symbol;Acc:HGNC:21384] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 6:10747759-10852753 471 524 485 1535 1703 970 3.36400093708449 3.40131332176375 3.12313417447338 9.82293080205684 9.97970673526204 6.49285969736296 3.29614947777387 8.76516574489395 -1.41099970279875 1.11675584407473e-08 2.04663161258484e-07 DOWN ENSG00000224470 ATXN1L ataxin 1-like [Source:HGNC Symbol;Acc:HGNC:33279] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:1903706|GO:0048286|GO:0006725|GO:0035295|GO:1901360|GO:0007275|GO:0030324|GO:0003676|GO:0048513|GO:0034641|GO:0043062|GO:0046483|GO:0043231|GO:0043005|GO:0009890|GO:0036477|GO:0030323|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0072089|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0003723|GO:0030097|GO:0010629|GO:0051252|GO:0060541|GO:1902035|GO:0031981|GO:0030425|GO:0005654|GO:1902033|GO:0010467|GO:0030198|GO:0009059|GO:0016070|GO:0005634|GO:2000648|GO:0071425|GO:0072091|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 developmental process|immune system process|cell|cellular process|metabolic process|binding|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|regulation of hemopoiesis|lung alveolus development|cellular aromatic compound metabolic process|tube development|organic cyclic compound metabolic process|multicellular organism development|lung development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|extracellular structure organization|heterocycle metabolic process|intracellular membrane-bounded organelle|neuron projection|negative regulation of biosynthetic process|somatodendritic compartment|respiratory tube development|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|stem cell proliferation|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|hemopoiesis|negative regulation of gene expression|regulation of RNA metabolic process|respiratory system development|positive regulation of hematopoietic stem cell proliferation|nuclear lumen|dendrite|nucleoplasm|regulation of hematopoietic stem cell proliferation|gene expression|extracellular matrix organization|macromolecule biosynthetic process|RNA metabolic process|nucleus|positive regulation of stem cell proliferation|hematopoietic stem cell proliferation|regulation of stem cell proliferation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 16:71845991-71885268 2331 2765 2783 1292 1438 1391 18.9591339969841 20.4386113856769 20.4081499018361 9.41535063641629 9.59628446935267 10.6030857269716 19.9352984281657 9.87157361091352 1.0139732166947 1.12180047272784e-08 2.05461541796423e-07 UP ENSG00000117597 DIEXF digestive organ expansion factor homolog (zebrafish) [Source:HGNC Symbol;Acc:HGNC:28440] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0022613|GO:0005730|GO:0003723|GO:0030684|GO:0042254|GO:0031981|GO:0042274|GO:0010467|GO:0016070|GO:0005634|GO:0006364|GO:0030490|GO:0006396|GO:0030515|GO:0019843|GO:0034660|GO:0032040|GO:0044822|GO:0000462|GO:0034511|GO:0016072 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|preribosome|ribosome biogenesis|nuclear lumen|ribosomal small subunit biogenesis|gene expression|RNA metabolic process|nucleus|rRNA processing|maturation of SSU-rRNA|RNA processing|snoRNA binding|rRNA binding|ncRNA metabolic process|small-subunit processome|poly(A) RNA binding|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|U3 snoRNA binding|rRNA metabolic process - - - - 1:209828007-209857565 1779 2113 1893 979 1058 908 11.2983365576192 12.1960155697938 10.8393561349731 5.57081799786314 5.51305364061154 5.40447136786326 11.4445694207954 5.49611433544598 1.0581792634699 1.12272657229066e-08 2.05505083317998e-07 UP ENSG00000165730 STOX1 storkhead box 1 [Source:HGNC Symbol;Acc:HGNC:23508] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0042391|GO:0006725|GO:0009888|GO:0022402|GO:1901360|GO:0048839|GO:0005938|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0051409|GO:0043231|GO:0005737|GO:0007423|GO:0009887|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0050673|GO:0045787|GO:0006979|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0001666|GO:0050790|GO:0051301|GO:0009967|GO:0044249|GO:0019538|GO:0040019|GO:0031323|GO:0006996|GO:0050679|GO:1902533|GO:0005730|GO:0032268|GO:1902882|GO:0003677|GO:0005813|GO:0010468|GO:0034645|GO:0090068|GO:0002009|GO:1903047|GO:0043412|GO:0010629|GO:0043583|GO:0043620|GO:0007005|GO:0051252|GO:0005815|GO:0044770|GO:0009790|GO:0010628|GO:0051347|GO:0036211|GO:0000278|GO:0071456|GO:2000027|GO:0042472|GO:0031981|GO:0007346|GO:0010564|GO:0051247|GO:0005654|GO:0006259|GO:0050678|GO:0051881|GO:0071453|GO:0032270|GO:0060429|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0007067|GO:0010467|GO:0048562|GO:0051246|GO:0071599|GO:0009059|GO:1902531|GO:0016070|GO:0045931|GO:0005856|GO:1904120|GO:0005634|GO:0071500|GO:0045995|GO:0000002|GO:0051896|GO:1901858|GO:0043491|GO:0071600|GO:0000975|GO:1904031|GO:0031401|GO:0000086|GO:0032774|GO:0044772|GO:0043565|GO:2001141|GO:0016310|GO:0061418|GO:0051897|GO:0003690|GO:1901990|GO:0042471|GO:1901989|GO:0015630|GO:1901992|GO:0010821|GO:0032042|GO:1901987|GO:0006464|GO:0043549|GO:0006351|GO:0006355|GO:0043618|GO:0033674|GO:0036294|GO:0006366|GO:0045859|GO:0045860|GO:0010389|GO:0006357|GO:0006468|GO:1903506|GO:0044212|GO:0042325|GO:0001932|GO:0018193|GO:1902751|GO:0001934|GO:0010971|GO:1902749|GO:0042327|GO:0000976|GO:0001012|GO:0033138|GO:0018105|GO:0033135|GO:0018107|GO:0010800|GO:0000977 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of membrane potential|cellular aromatic compound metabolic process|tissue development|cell cycle process|organic cyclic compound metabolic process|inner ear development|cell cortex|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|response to nitrosative stress|intracellular membrane-bounded organelle|cytoplasm|sensory organ development|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|epithelial cell proliferation|positive regulation of cell cycle|response to oxidative stress|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|response to hypoxia|regulation of catalytic activity|cell division|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|positive regulation of embryonic development|regulation of cellular metabolic process|organelle organization|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|nucleolus|regulation of cellular protein metabolic process|regulation of response to oxidative stress|DNA binding|centrosome|regulation of gene expression|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|morphogenesis of an epithelium|mitotic cell cycle process|macromolecule modification|negative regulation of gene expression|ear development|regulation of DNA-templated transcription in response to stress|mitochondrion organization|regulation of RNA metabolic process|microtubule organizing center|cell cycle phase transition|embryo development|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|mitotic cell cycle|cellular response to hypoxia|regulation of organ morphogenesis|inner ear morphogenesis|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|nucleoplasm|DNA metabolic process|regulation of epithelial cell proliferation|regulation of mitochondrial membrane potential|cellular response to oxygen levels|positive regulation of cellular protein metabolic process|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|gene expression|embryonic organ morphogenesis|regulation of protein metabolic process|otic vesicle development|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of mitotic cell cycle|cytoskeleton|positive regulation of otic vesicle morphogenesis|nucleus|cellular response to nitrosative stress|regulation of embryonic development|mitochondrial genome maintenance|regulation of protein kinase B signaling|regulation of mitochondrial DNA metabolic process|protein kinase B signaling|otic vesicle morphogenesis|regulatory region DNA binding|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein modification process|G2/M transition of mitotic cell cycle|RNA biosynthetic process|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of RNA biosynthetic process|phosphorylation|regulation of transcription from RNA polymerase II promoter in response to hypoxia|positive regulation of protein kinase B signaling|double-stranded DNA binding|regulation of mitotic cell cycle phase transition|ear morphogenesis|positive regulation of cell cycle phase transition|microtubule cytoskeleton|positive regulation of mitotic cell cycle phase transition|regulation of mitochondrion organization|mitochondrial DNA metabolic process|regulation of cell cycle phase transition|cellular protein modification process|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of kinase activity|cellular response to decreased oxygen levels|transcription from RNA polymerase II promoter|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of G2/M transition of mitotic cell cycle|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of cell cycle G2/M phase transition|positive regulation of protein phosphorylation|positive regulation of G2/M transition of mitotic cell cycle|regulation of cell cycle G2/M phase transition|positive regulation of phosphorylation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|positive regulation of peptidyl-serine phosphorylation|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 10:68827541-68895432 7 35 27 129 170 102 0.116154837230027 0.527817498809595 0.40393479468318 1.91786100265716 2.31445128568327 1.58620507378186 0.349302376907601 1.9395057873741 -2.47314071576916 1.12585401988146e-08 2.05834276405807e-07 DOWN ENSG00000212719 C17orf51 chromosome 17 open reading frame 51 [Source:HGNC Symbol;Acc:HGNC:27904] - - - - - - 17:21524790-21574458 370 534 321 157 169 129 2.68354465168679 3.51988928119951 2.09907249854322 1.02024415145153 1.00568467171982 0.876850087663454 2.76750214380984 0.967592970278268 1.51611224152007 1.12590397725826e-08 2.05834276405807e-07 UP ENSG00000226937 CEP164P1 centrosomal protein 164kDa pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44988] - - - - - - 10:45002222-45076066 36 32 34 4 7 8 0.473422715752322 0.382449092123113 0.403120843936516 0.0471320710963634 0.0755285794838571 0.0985975980241953 0.41966421727065 0.0737527495348053 2.50846671708931 1.12770462717396e-08 2.06037294612309e-07 UP ENSG00000104549 SQLE squalene epoxidase [Source:HGNC Symbol;Acc:HGNC:11279] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0006725|GO:1901360|GO:0043168|GO:0044281|GO:0043231|GO:0005737|GO:0016705|GO:0004497|GO:0006629|GO:0005783|GO:0050662|GO:0000166|GO:0016021|GO:0010033|GO:0055114|GO:0050660|GO:0006066|GO:0016709|GO:0008202|GO:0008610|GO:0006694|GO:0071949|GO:0016125|GO:0004506|GO:0016126|GO:0008203|GO:0006695 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|lipid metabolic process|endoplasmic reticulum|coenzyme binding|nucleotide binding|integral component of membrane|response to organic substance|oxidation-reduction process|flavin adenine dinucleotide binding|alcohol metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|steroid metabolic process|lipid biosynthetic process|steroid biosynthetic process|FAD binding|sterol metabolic process|squalene monooxygenase activity|sterol biosynthetic process|cholesterol metabolic process|cholesterol biosynthetic process K00511 squalene monooxygenase[1.14.14.17] hsa01100|hsa00100 Metabolic pathways - Homo sapiens (human)|Steroid biosynthesis - Homo sapiens (human) 8:124998497-125022283 1283 1550 1920 637 849 832 15.7698295104693 17.3145855640641 21.2772642767525 7.01515631085921 8.56201699485763 9.58412698450058 18.120559783762 8.38710009673914 1.11138354480352 1.14457743002584e-08 2.08992138201783e-07 UP ENSG00000104221 BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit [Source:HGNC Symbol;Acc:HGNC:17298] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:0006352|GO:0006383|GO:1903506|GO:0008270 cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA-templated transcription, initiation|transcription from RNA polymerase III promoter|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 8:37843268-37849904 400 391 363 144 197 110 6.55578090784151 5.82399572232948 5.36394781405155 2.11457881935217 2.64909998133876 1.68960813468587 5.91457481474085 2.1510956451256 1.45920278686455 1.15850442840899e-08 2.11405814215905e-07 UP ENSG00000163527 STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) [Source:HGNC Symbol;Acc:HGNC:30611] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0033554|GO:0043231|GO:0005737|GO:0005975|GO:0005783|GO:0016757|GO:0008250|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0036503|GO:0034645|GO:0043412|GO:0006487|GO:0030163|GO:0044265|GO:0009100|GO:0036211|GO:0016758|GO:0006986|GO:0030433|GO:1990234|GO:0006508|GO:0070085|GO:1901137|GO:0044267|GO:0009059|GO:0034976|GO:0044257|GO:0009101|GO:0043413|GO:0010498|GO:0004576|GO:0018279|GO:0006516|GO:0051603|GO:0006464|GO:0019941|GO:0004579|GO:0018193|GO:0043686|GO:0043687|GO:0043161|GO:0006511 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein complex|endomembrane system|transferase activity|organelle membrane|protein glycosylation|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|oligosaccharyltransferase complex|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|ERAD pathway|cellular macromolecule biosynthetic process|macromolecule modification|protein N-linked glycosylation|protein catabolic process|cellular macromolecule catabolic process|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|response to unfolded protein|ER-associated ubiquitin-dependent protein catabolic process|transferase complex|proteolysis|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|response to endoplasmic reticulum stress|cellular protein catabolic process|glycoprotein biosynthetic process|macromolecule glycosylation|proteasomal protein catabolic process|oligosaccharyl transferase activity|protein N-linked glycosylation via asparagine|glycoprotein catabolic process|proteolysis involved in cellular protein catabolic process|cellular protein modification process|modification-dependent protein catabolic process|dolichyl-diphosphooligosaccharide-protein glycotransferase activity|peptidyl-amino acid modification|co-translational protein modification|post-translational protein modification|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process K07151 dolichyl-diphosphooligosaccharide--protein glycosyltransferase[2.4.99.18] hsa01100|hsa04141|hsa00510 Metabolic pathways - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 3:31532638-31637622 1558 1803 2380 4551 4992 4242 14.7771511351979 15.5417213424312 20.3523499060482 38.6747849697747 38.8477547543823 37.707087796223 16.8904074612258 38.4098758401267 -1.18527316848557 1.17492692856441e-08 2.14271646459144e-07 DOWN ENSG00000099995 SF3A1 splicing factor 3a subunit 1 [Source:HGNC Symbol;Acc:HGNC:10765] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0030529|GO:0006139|GO:0022613|GO:0003723|GO:0030532|GO:0022618|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0097525|GO:0034622|GO:0006396|GO:0071010|GO:0005684|GO:0006376|GO:0016071|GO:0044822|GO:0000245|GO:0071013|GO:0000389|GO:0005686|GO:0006397|GO:0071004|GO:0008380|GO:0000375|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|RNA binding|small nuclear ribonucleoprotein complex|ribonucleoprotein complex assembly|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|spliceosomal snRNP complex|cellular macromolecular complex assembly|RNA processing|prespliceosome|U2-type spliceosomal complex|mRNA splice site selection|mRNA metabolic process|poly(A) RNA binding|spliceosomal complex assembly|catalytic step 2 spliceosome|mRNA 3'-splice site recognition|U2 snRNP|mRNA processing|U2-type prespliceosome|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome K12825 splicing factor 3A subunit 1[-] hsa03040 Spliceosome - Homo sapiens (human) 22:30331988-30356947 5390 5667 5491 2809 3165 2266 39.7447787162425 37.9773373555671 36.5053864655133 18.5584092483866 19.1484186034798 15.6595775042496 38.0758341791076 17.788801785372 1.09790630703446 1.17834204300438e-08 2.1476326832633e-07 UP ENSG00000182923 CEP63 centrosomal protein 63kDa [Source:HGNC Symbol;Acc:HGNC:25815] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0016043|GO:0005622|GO:0005515|GO:0007049|GO:0022402|GO:0033554|GO:0022607|GO:0005737|GO:0007154|GO:0007165|GO:0051301|GO:0007017|GO:0006996|GO:0031023|GO:0005829|GO:0005813|GO:0000075|GO:1903047|GO:0007010|GO:0005815|GO:0044770|GO:0007098|GO:0098534|GO:0005814|GO:0000278|GO:0007099|GO:0007051|GO:0006461|GO:0070925|GO:0035556|GO:0007067|GO:0051298|GO:0000226|GO:0005856|GO:0000922|GO:0005819|GO:0006974|GO:0051225|GO:0042770|GO:0000086|GO:0044772|GO:0098535|GO:0000077|GO:0015630|GO:0051297 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|cellular component organization|intracellular|protein binding|cell cycle|cell cycle process|cellular response to stress|cellular component assembly|cytoplasm|cell communication|signal transduction|cell division|microtubule-based process|organelle organization|microtubule organizing center organization|cytosol|centrosome|cell cycle checkpoint|mitotic cell cycle process|cytoskeleton organization|microtubule organizing center|cell cycle phase transition|centrosome cycle|centriole assembly|centriole|mitotic cell cycle|centriole replication|spindle organization|protein complex assembly|organelle assembly|intracellular signal transduction|mitotic nuclear division|centrosome duplication|microtubule cytoskeleton organization|cytoskeleton|spindle pole|spindle|cellular response to DNA damage stimulus|spindle assembly|signal transduction in response to DNA damage|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|de novo centriole assembly|DNA damage checkpoint|microtubule cytoskeleton|centrosome organization - - - - 3:134485743-134575017 142 183 228 452 522 541 0.660136025583709 0.773173416477891 0.955638496656694 1.88270134102975 1.9910572749423 2.3570650184918 0.796315979572765 2.07694121148795 -1.38304746739412 1.17944631072173e-08 2.14833374986495e-07 DOWN ENSG00000135002 RFK riboflavin kinase [Source:HGNC Symbol;Acc:HGNC:30324] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0072593|GO:0006771|GO:0051186|GO:0006139|GO:0043085|GO:0055086|GO:0008219|GO:0050790|GO:0000166|GO:0044249|GO:0005829|GO:0046872|GO:0035639|GO:0019693|GO:0001883|GO:0032549|GO:0005739|GO:0016301|GO:0051353|GO:0009231|GO:0051341|GO:0012501|GO:0006796|GO:1901137|GO:0017076|GO:0016773|GO:0006766|GO:0033864|GO:0009124|GO:0009259|GO:0009117|GO:0005524|GO:0046390|GO:0030554|GO:0016310|GO:0009108|GO:0008531|GO:0009165|GO:0006767|GO:0006915|GO:0009398|GO:0009156 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|reactive oxygen species metabolic process|riboflavin metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|cell death|regulation of catalytic activity|nucleotide binding|cellular biosynthetic process|cytosol|metal ion binding|purine ribonucleoside triphosphate binding|ribose phosphate metabolic process|purine nucleoside binding|ribonucleoside binding|mitochondrion|kinase activity|positive regulation of oxidoreductase activity|riboflavin biosynthetic process|regulation of oxidoreductase activity|programmed cell death|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|vitamin metabolic process|positive regulation of NAD(P)H oxidase activity|nucleoside monophosphate biosynthetic process|ribonucleotide metabolic process|nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|adenyl nucleotide binding|phosphorylation|coenzyme biosynthetic process|riboflavin kinase activity|nucleotide biosynthetic process|water-soluble vitamin metabolic process|apoptotic process|FMN biosynthetic process|ribonucleoside monophosphate biosynthetic process K00861 riboflavin kinase[2.7.1.26] hsa01100|hsa00740 Metabolic pathways - Homo sapiens (human)|Riboflavin metabolism - Homo sapiens (human) 9:76385517-76394517 1414 1497 1470 630 801 771 13.2584698137763 12.7569251505377 12.4272711418921 5.29276122214381 6.16232680669199 6.77528190754337 12.814222035402 6.07678997879306 1.07636455721578 1.18399165722265e-08 2.15421104380294e-07 UP ENSG00000165891 E2F7 E2F transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:23820] GO:0032502|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0044237|GO:0003006|GO:0000989|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0051726|GO:0042127|GO:0007049|GO:0001890|GO:0003712|GO:0006725|GO:0009888|GO:0022402|GO:1901360|GO:0001568|GO:0007275|GO:0003676|GO:0048513|GO:0060706|GO:0051302|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0060717|GO:0045786|GO:0043231|GO:0048608|GO:0000981|GO:0005667|GO:0048568|GO:0051782|GO:0009890|GO:0045787|GO:0006139|GO:0001892|GO:0001525|GO:0007154|GO:0007165|GO:0008285|GO:0051301|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0048732|GO:0003677|GO:0002040|GO:0010468|GO:0032466|GO:0034645|GO:0003714|GO:0090068|GO:1903047|GO:0001944|GO:0061458|GO:0072358|GO:0010629|GO:0051252|GO:0044770|GO:0009790|GO:0001889|GO:0010628|GO:0060707|GO:0000278|GO:0032465|GO:0007346|GO:0010564|GO:0045930|GO:0006259|GO:0060429|GO:0051054|GO:0035556|GO:0010467|GO:0001227|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0072359|GO:0000910|GO:0010557|GO:0005634|GO:0006974|GO:0060718|GO:0010948|GO:0000083|GO:0032877|GO:0000975|GO:0045893|GO:0009792|GO:0006260|GO:0030855|GO:0045892|GO:0072331|GO:0042770|GO:0032774|GO:0044772|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:1901990|GO:0070365|GO:0042023|GO:0006275|GO:0032875|GO:1901987|GO:0045740|GO:0006351|GO:0006355|GO:1901991|GO:0045944|GO:2000045|GO:0006366|GO:1903507|GO:0006357|GO:0006261|GO:1903506|GO:0044212|GO:1902806|GO:2000134|GO:0000082|GO:2000105|GO:0043009|GO:0071930|GO:0000122|GO:1902807|GO:0030330|GO:0001047|GO:0000976|GO:0001012|GO:0001701|GO:0000977 developmental process|macromolecular complex|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|cellular metabolic process|developmental process involved in reproduction|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|regulation of cell cycle|regulation of cell proliferation|cell cycle|placenta development|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell cycle process|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|nucleic acid binding|animal organ development|cell differentiation involved in embryonic placenta development|regulation of cell division|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|chorion development|negative regulation of cell cycle|intracellular membrane-bounded organelle|reproductive structure development|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor complex|embryonic organ development|negative regulation of cell division|negative regulation of biosynthetic process|positive regulation of cell cycle|nucleobase-containing compound metabolic process|embryonic placenta development|angiogenesis|cell communication|signal transduction|negative regulation of cell proliferation|cell division|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|DNA binding|sprouting angiogenesis|regulation of gene expression|negative regulation of cytokinesis|cellular macromolecule biosynthetic process|transcription corepressor activity|positive regulation of cell cycle process|mitotic cell cycle process|vasculature development|reproductive system development|cardiovascular system development|negative regulation of gene expression|regulation of RNA metabolic process|cell cycle phase transition|embryo development|liver development|positive regulation of gene expression|trophoblast giant cell differentiation|mitotic cell cycle|regulation of cytokinesis|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|DNA metabolic process|epithelium development|positive regulation of DNA metabolic process|intracellular signal transduction|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|circulatory system development|cytokinesis|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|chorionic trophoblast cell differentiation|negative regulation of cell cycle process|regulation of transcription involved in G1/S transition of mitotic cell cycle|positive regulation of DNA endoreduplication|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|DNA replication|epithelial cell differentiation|negative regulation of transcription, DNA-templated|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|regulation of mitotic cell cycle phase transition|hepatocyte differentiation|DNA endoreduplication|regulation of DNA replication|regulation of DNA endoreduplication|regulation of cell cycle phase transition|positive regulation of DNA replication|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of mitotic cell cycle phase transition|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of cell cycle G1/S phase transition|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of DNA-dependent DNA replication|chordate embryonic development|negative regulation of transcription involved in G1/S transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 12:77021247-77065580 25 31 55 168 148 121 0.15716658950653 0.177118449085409 0.311739489627501 0.946284974109133 0.763387656963423 0.712901033168282 0.21534150940648 0.807524554746946 -1.90687968772877 1.18411613950581e-08 2.15421104380294e-07 DOWN ENSG00000256417 RP11-1038A11.3 - - - - - - - 12:5290480-5383653 2 1 5 20 31 34 0.0862604426197135 0.0392181260591094 0.194424930369938 0.772898130441859 1.09707590096268 1.37438866453904 0.10663449968292 1.08145423198119 -3.34222643369099 1.18687133838248e-08 2.15790846139284e-07 DOWN ENSG00000006451 RALA v-ral simian leukemia viral oncogene homolog A (ras related) [Source:HGNC Symbol;Acc:HGNC:9839] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0030496|GO:0051716|GO:0097159|GO:0030055|GO:0050794|GO:0043229|GO:0043209|GO:0044089|GO:0043167|GO:0009986|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0031090|GO:0016032|GO:0060341|GO:0007049|GO:0006935|GO:0035239|GO:0009888|GO:0006810|GO:0022402|GO:0035295|GO:0051130|GO:0007275|GO:0060627|GO:0005102|GO:0043168|GO:0005924|GO:0032940|GO:0005912|GO:0001882|GO:0031982|GO:0051491|GO:0051128|GO:0016817|GO:0022607|GO:0051668|GO:0043231|GO:0019899|GO:0005737|GO:0012506|GO:0021915|GO:0048729|GO:0048598|GO:0045184|GO:0008104|GO:0007154|GO:0035148|GO:0061024|GO:0060491|GO:0007165|GO:0070062|GO:0051649|GO:0008092|GO:0000166|GO:0030030|GO:0051301|GO:0030029|GO:0010033|GO:0032154|GO:0006996|GO:0016192|GO:0031344|GO:0007166|GO:0002009|GO:0035639|GO:0007010|GO:0031410|GO:0051665|GO:0017022|GO:0001883|GO:0051117|GO:0015031|GO:0031346|GO:0009790|GO:0016023|GO:0006887|GO:0072175|GO:0016818|GO:0046907|GO:0032549|GO:0017157|GO:0051046|GO:0016331|GO:0030031|GO:0070848|GO:0031988|GO:0001664|GO:0030036|GO:0001841|GO:0034613|GO:0060429|GO:0035556|GO:0030659|GO:0007399|GO:0060562|GO:0046903|GO:0071310|GO:0017076|GO:0019003|GO:0060606|GO:0000910|GO:0005925|GO:0044389|GO:0051489|GO:0031625|GO:0032561|GO:0009792|GO:0031532|GO:0030139|GO:0051169|GO:0001843|GO:0001838|GO:0071363|GO:0038179|GO:0006886|GO:0007167|GO:0046847|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0048011|GO:0007265|GO:0006913|GO:0017111|GO:0043009|GO:0031755|GO:0007169|GO:0003924 locomotion|developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|midbody|cellular response to stimulus|organic cyclic compound binding|cell-substrate junction|regulation of cellular process|intracellular organelle|myelin sheath|positive regulation of cellular component biogenesis|ion binding|cell surface|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|hydrolase activity|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|viral process|regulation of cellular localization|cell cycle|chemotaxis|tube morphogenesis|tissue development|transport|cell cycle process|tube development|positive regulation of cellular component organization|multicellular organism development|regulation of vesicle-mediated transport|receptor binding|anion binding|cell-substrate adherens junction|secretion by cell|adherens junction|nucleoside binding|vesicle|positive regulation of filopodium assembly|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|cellular component assembly|localization within membrane|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|vesicle membrane|neural tube development|tissue morphogenesis|embryonic morphogenesis|establishment of protein localization|protein localization|cell communication|tube formation|membrane organization|regulation of cell projection assembly|signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|nucleotide binding|cell projection organization|cell division|actin filament-based process|response to organic substance|cleavage furrow|organelle organization|vesicle-mediated transport|regulation of cell projection organization|cell surface receptor signaling pathway|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|cytoskeleton organization|cytoplasmic vesicle|membrane raft localization|myosin binding|purine nucleoside binding|ATPase binding|protein transport|positive regulation of cell projection organization|embryo development|cytoplasmic, membrane-bounded vesicle|exocytosis|epithelial tube formation|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|regulation of exocytosis|regulation of secretion|morphogenesis of embryonic epithelium|cell projection assembly|response to growth factor|membrane-bounded vesicle|G-protein coupled receptor binding|actin cytoskeleton organization|neural tube formation|cellular protein localization|epithelium development|intracellular signal transduction|cytoplasmic vesicle membrane|nervous system development|epithelial tube morphogenesis|secretion|cellular response to organic substance|purine nucleotide binding|GDP binding|tube closure|cytokinesis|focal adhesion|ubiquitin-like protein ligase binding|regulation of filopodium assembly|ubiquitin protein ligase binding|guanyl ribonucleotide binding|embryo development ending in birth or egg hatching|actin cytoskeleton reorganization|endocytic vesicle|nuclear transport|neural tube closure|embryonic epithelial tube formation|cellular response to growth factor stimulus|neurotrophin signaling pathway|intracellular protein transport|enzyme linked receptor protein signaling pathway|filopodium assembly|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|nucleocytoplasmic transport|nucleoside-triphosphatase activity|chordate embryonic development|Edg-2 lysophosphatidic acid receptor binding|transmembrane receptor protein tyrosine kinase signaling pathway|GTPase activity K07834 Ras-related protein Ral-A[-] hsa05200|hsa04014|hsa04015|hsa04072|hsa05212 Pathways in cancer - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human) 7:39623483-39708124 287 304 543 1046 1065 938 4.19019470585808 4.03371307162789 7.1476947639711 13.6829984910893 12.7576180966305 12.8346453093074 5.12386751381902 13.0917539656757 -1.3533533170963 1.19327064899463e-08 2.16822288223285e-07 DOWN ENSG00000178607 ERN1 endoplasmic reticulum to nucleus signaling 1 [Source:HGNC Symbol;Acc:HGNC:3449] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0006914|GO:0023051|GO:0043227|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0042802|GO:0051726|GO:0007049|GO:0010506|GO:0006725|GO:0019866|GO:0022402|GO:1901360|GO:0009991|GO:0034641|GO:0043168|GO:0016788|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0045786|GO:0043231|GO:0031227|GO:0043169|GO:0019899|GO:0005737|GO:0005635|GO:0042592|GO:1990630|GO:0009966|GO:0046983|GO:1990597|GO:0050673|GO:0019725|GO:1990604|GO:0010646|GO:0006139|GO:0043085|GO:0030176|GO:0007154|GO:0007165|GO:0005783|GO:0008219|GO:0016236|GO:0031965|GO:0050790|GO:0031072|GO:0000166|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031301|GO:0010033|GO:0031323|GO:1990332|GO:0000165|GO:1902533|GO:0032268|GO:0009743|GO:0010468|GO:0034645|GO:0046872|GO:0030968|GO:0051879|GO:0035639|GO:0043412|GO:0051345|GO:0048878|GO:0051252|GO:0001883|GO:0044265|GO:0007050|GO:1900101|GO:0032075|GO:0010628|GO:0001935|GO:0051347|GO:0036211|GO:0030544|GO:0032549|GO:0055082|GO:0016241|GO:0043531|GO:0005637|GO:0006986|GO:0031098|GO:0004518|GO:1990234|GO:0051247|GO:0070848|GO:0005739|GO:0016301|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0017076|GO:0019439|GO:0051246|GO:0009059|GO:1901142|GO:0035967|GO:1902531|GO:0016070|GO:0031667|GO:0016773|GO:0034976|GO:0005634|GO:0042803|GO:1900103|GO:0097190|GO:0034620|GO:0070059|GO:0006401|GO:0071322|GO:0070304|GO:0097193|GO:0090501|GO:0031401|GO:0001678|GO:0006396|GO:0036498|GO:0043408|GO:0000287|GO:0032774|GO:0005524|GO:2001141|GO:0034284|GO:0071363|GO:0043484|GO:0030554|GO:0016310|GO:0016071|GO:0043410|GO:0004519|GO:0032872|GO:0004540|GO:0004672|GO:0090305|GO:0006464|GO:0033120|GO:0051403|GO:0006987|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0033500|GO:0033674|GO:0071333|GO:0042593|GO:0045859|GO:0045860|GO:0043406|GO:0046328|GO:1902911|GO:0006468|GO:1903506|GO:0006402|GO:0043405|GO:0042325|GO:0035924|GO:0007254|GO:0001932|GO:0006397|GO:0018193|GO:0090502|GO:0004521|GO:0004674|GO:0006379|GO:0032874|GO:0001934|GO:0008380|GO:0042327|GO:0046330|GO:1902554|GO:0043507|GO:0000187|GO:0046777|GO:0071902|GO:0009749|GO:0018105|GO:0070054|GO:0070055|GO:0071900|GO:0043506|GO:0032147|GO:0007257|GO:0036289|GO:1990579 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|autophagy|regulation of signaling|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|identical protein binding|regulation of cell cycle|cell cycle|regulation of autophagy|cellular aromatic compound metabolic process|organelle inner membrane|cell cycle process|organic cyclic compound metabolic process|response to extracellular stimulus|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cation binding|enzyme binding|cytoplasm|nuclear envelope|homeostatic process|IRE1-RACK1-PP2A complex|regulation of signal transduction|protein dimerization activity|AIP1-IRE1 complex|epithelial cell proliferation|cellular homeostasis|IRE1-TRAF2-ASK1 complex|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|integral component of endoplasmic reticulum membrane|cell communication|signal transduction|endoplasmic reticulum|cell death|macroautophagy|nuclear membrane|regulation of catalytic activity|heat shock protein binding|nucleotide binding|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|integral component of organelle membrane|response to organic substance|regulation of cellular metabolic process|Ire1 complex|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|response to carbohydrate|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|endoplasmic reticulum unfolded protein response|Hsp90 protein binding|purine ribonucleoside triphosphate binding|macromolecule modification|positive regulation of hydrolase activity|chemical homeostasis|regulation of RNA metabolic process|purine nucleoside binding|cellular macromolecule catabolic process|cell cycle arrest|regulation of endoplasmic reticulum unfolded protein response|positive regulation of nuclease activity|positive regulation of gene expression|endothelial cell proliferation|positive regulation of transferase activity|protein modification process|Hsp70 protein binding|ribonucleoside binding|cellular chemical homeostasis|regulation of macroautophagy|ADP binding|nuclear inner membrane|response to unfolded protein|stress-activated protein kinase signaling cascade|nuclease activity|transferase complex|positive regulation of protein metabolic process|response to growth factor|mitochondrion|kinase activity|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|purine nucleotide binding|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|insulin metabolic process|cellular response to topologically incorrect protein|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|response to endoplasmic reticulum stress|nucleus|protein homodimerization activity|positive regulation of endoplasmic reticulum unfolded protein response|apoptotic signaling pathway|cellular response to unfolded protein|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|RNA catabolic process|cellular response to carbohydrate stimulus|positive regulation of stress-activated protein kinase signaling cascade|intrinsic apoptotic signaling pathway|RNA phosphodiester bond hydrolysis|positive regulation of protein modification process|cellular glucose homeostasis|RNA processing|IRE1-mediated unfolded protein response|regulation of MAPK cascade|magnesium ion binding|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|response to monosaccharide|cellular response to growth factor stimulus|regulation of RNA splicing|adenyl nucleotide binding|phosphorylation|mRNA metabolic process|positive regulation of MAPK cascade|endonuclease activity|regulation of stress-activated MAPK cascade|ribonuclease activity|protein kinase activity|nucleic acid phosphodiester bond hydrolysis|cellular protein modification process|positive regulation of RNA splicing|stress-activated MAPK cascade|activation of signaling protein activity involved in unfolded protein response|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|carbohydrate homeostasis|positive regulation of kinase activity|cellular response to glucose stimulus|glucose homeostasis|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of JNK cascade|protein kinase complex|protein phosphorylation|regulation of nucleic acid-templated transcription|mRNA catabolic process|regulation of MAP kinase activity|regulation of phosphorylation|cellular response to vascular endothelial growth factor stimulus|JNK cascade|regulation of protein phosphorylation|mRNA processing|peptidyl-amino acid modification|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|protein serine/threonine kinase activity|mRNA cleavage|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|RNA splicing|positive regulation of phosphorylation|positive regulation of JNK cascade|serine/threonine protein kinase complex|positive regulation of JUN kinase activity|activation of MAPK activity|protein autophosphorylation|positive regulation of protein serine/threonine kinase activity|response to glucose|peptidyl-serine phosphorylation|mRNA splicing, via endonucleolytic cleavage and ligation|mRNA endonucleolytic cleavage involved in unfolded protein response|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|activation of protein kinase activity|activation of JUN kinase activity|peptidyl-serine autophosphorylation|peptidyl-serine trans-autophosphorylation K08852 serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-][-] hsa04141|hsa05010|hsa04932|hsa04210 Protein processing in endoplasmic reticulum - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Apoptosis - Homo sapiens (human) 17:64039142-64130819 50 89 144 307 351 403 0.287288658054264 0.464755122223626 0.745981032744033 1.58047668825211 1.65473288590844 2.17013566657783 0.499341604340641 1.80178174691279 -1.85132524564826 1.20594508898045e-08 2.18991999309138e-07 DOWN ENSG00000122970 IFT81 intraflagellar transport 81 [Source:HGNC Symbol;Acc:HGNC:14313] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0042995|GO:0043229|GO:0044702|GO:0019953|GO:0051641|GO:0009653|GO:0016043|GO:0032504|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0048609|GO:0030992|GO:0036126|GO:0006810|GO:0030990|GO:0022607|GO:0097225|GO:0031514|GO:0006928|GO:0045184|GO:0072372|GO:0036064|GO:0097228|GO:0008104|GO:0010970|GO:0007276|GO:0051649|GO:0008092|GO:0097542|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0015631|GO:0000902|GO:0005813|GO:0048232|GO:0005815|GO:0015031|GO:0044782|GO:0046907|GO:0030031|GO:0007018|GO:0034613|GO:0070925|GO:0042384|GO:0032990|GO:0031503|GO:0048858|GO:0005856|GO:0060271|GO:0007283|GO:0042073|GO:0006886|GO:0015630|GO:0030705|GO:0035735 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|binding|cell projection|intracellular organelle|single organism reproductive process|sexual reproduction|cellular localization|anatomical structure morphogenesis|cellular component organization|multicellular organism reproduction|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|intraciliary transport particle B|sperm flagellum|transport|intraciliary transport particle|cellular component assembly|sperm midpiece|motile cilium|movement of cell or subcellular component|establishment of protein localization|primary cilium|ciliary basal body|sperm principal piece|protein localization|establishment of localization by movement along microtubule|gamete generation|establishment of localization in cell|cytoskeletal protein binding|ciliary tip|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|tubulin binding|cell morphogenesis|centrosome|male gamete generation|microtubule organizing center|protein transport|cilium organization|intracellular transport|cell projection assembly|microtubule-based movement|cellular protein localization|organelle assembly|cilium assembly|cell part morphogenesis|protein complex localization|cell projection morphogenesis|cytoskeleton|cilium morphogenesis|spermatogenesis|intraciliary transport|intracellular protein transport|microtubule cytoskeleton|cytoskeleton-dependent intracellular transport|intraciliary transport involved in cilium morphogenesis - - - - 12:110124335-110218797 111 138 190 407 437 396 0.769556985442052 0.869513641763363 1.18764051137968 2.52819184701746 2.4858084524907 2.57301474633395 0.942237046195032 2.5290050152807 -1.42440793694444 1.21399659670538e-08 2.20320087526093e-07 DOWN ENSG00000256235 SMIM3 small integral membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:30248] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 5:150777946-150796734 159 192 204 84 62 52 4.82295603167881 5.29295111457176 5.5790689818014 2.28293278916723 1.54303208996941 1.47825122647674 5.23165870935066 1.76807203520446 1.56509137421331 1.22331382642798e-08 2.21876129855292e-07 UP ENSG00000167657 DAPK3 death-associated protein kinase 3 [Source:HGNC Symbol;Acc:HGNC:2676] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0006914|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0042802|GO:0051272|GO:0051726|GO:0007049|GO:0008360|GO:0010506|GO:0045087|GO:0006725|GO:0008022|GO:0022402|GO:1901360|GO:0005884|GO:0010941|GO:0007275|GO:0051302|GO:0034641|GO:0043168|GO:0006952|GO:0030155|GO:0001882|GO:0016772|GO:0046483|GO:0051128|GO:2000147|GO:0022607|GO:0010942|GO:0043231|GO:0019899|GO:0005737|GO:0032970|GO:0003012|GO:0006928|GO:1901888|GO:0031589|GO:0009966|GO:0046983|GO:0009890|GO:0019904|GO:0010646|GO:0006139|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0008134|GO:0008219|GO:0000166|GO:0051301|GO:0048869|GO:0030029|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:2001235|GO:0032268|GO:0030111|GO:0000902|GO:0010468|GO:0006936|GO:0034645|GO:0045216|GO:0006518|GO:0007166|GO:0032956|GO:0035639|GO:1903047|GO:0043412|GO:0007010|GO:0034097|GO:0010629|GO:0051252|GO:0006325|GO:0008140|GO:0001883|GO:0030275|GO:0090257|GO:0030334|GO:0036211|GO:0032269|GO:0000278|GO:0007160|GO:0032549|GO:0034329|GO:0034341|GO:0031981|GO:0007346|GO:0010564|GO:0010810|GO:0005654|GO:0022604|GO:0016301|GO:0030036|GO:0012501|GO:0006796|GO:0043603|GO:0035556|GO:0033043|GO:0044267|GO:0007067|GO:0010467|GO:0007399|GO:0071310|GO:0017076|GO:0051246|GO:0030177|GO:0009059|GO:0051020|GO:0030154|GO:0045121|GO:0030335|GO:0043068|GO:0016070|GO:0016773|GO:0005856|GO:0000910|GO:0005634|GO:0042803|GO:0043067|GO:0097190|GO:0030182|GO:0015629|GO:0016055|GO:0043043|GO:0031532|GO:0006939|GO:0043065|GO:0071346|GO:0006937|GO:0060828|GO:0034332|GO:0007088|GO:0032774|GO:2000249|GO:0017148|GO:0005524|GO:2001141|GO:0097192|GO:2001236|GO:0030554|GO:0016310|GO:0010608|GO:2001238|GO:0016604|GO:0006412|GO:0051493|GO:0001952|GO:0007044|GO:0006417|GO:0031267|GO:0042981|GO:0048041|GO:0071345|GO:0043522|GO:0004672|GO:0016568|GO:0043519|GO:0022008|GO:0051893|GO:0006464|GO:0090263|GO:0097191|GO:0006351|GO:0006915|GO:0006355|GO:0034333|GO:0006940|GO:0017016|GO:0006468|GO:0048699|GO:1903506|GO:0060070|GO:2001239|GO:2001241|GO:0016605|GO:0004674|GO:0017048|GO:0046777 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|autophagy|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|identical protein binding|positive regulation of cellular component movement|regulation of cell cycle|cell cycle|regulation of cell shape|regulation of autophagy|innate immune response|cellular aromatic compound metabolic process|protein C-terminus binding|cell cycle process|organic cyclic compound metabolic process|actin filament|regulation of cell death|multicellular organism development|regulation of cell division|cellular nitrogen compound metabolic process|anion binding|defense response|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|positive regulation of cell death|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of actin filament-based process|muscle system process|movement of cell or subcellular component|regulation of cell junction assembly|cell-substrate adhesion|regulation of signal transduction|protein dimerization activity|negative regulation of biosynthetic process|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|regulation of cellular component movement|cell migration|signal transduction|transcription factor binding|cell death|nucleotide binding|cell division|cellular developmental process|actin filament-based process|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|cell-cell junction organization|peptide metabolic process|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|response to cytokine|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|cAMP response element binding protein binding|purine nucleoside binding|LRR domain binding|regulation of muscle system process|regulation of cell migration|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|cell-matrix adhesion|ribonucleoside binding|cell junction assembly|response to interferon-gamma|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|regulation of cell-substrate adhesion|nucleoplasm|regulation of cell morphogenesis|kinase activity|actin cytoskeleton organization|programmed cell death|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|mitotic nuclear division|gene expression|nervous system development|cellular response to organic substance|purine nucleotide binding|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|GTPase binding|cell differentiation|membrane raft|positive regulation of cell migration|positive regulation of programmed cell death|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|cytokinesis|nucleus|protein homodimerization activity|regulation of programmed cell death|apoptotic signaling pathway|neuron differentiation|actin cytoskeleton|Wnt signaling pathway|peptide biosynthetic process|actin cytoskeleton reorganization|smooth muscle contraction|positive regulation of apoptotic process|cellular response to interferon-gamma|regulation of muscle contraction|regulation of canonical Wnt signaling pathway|adherens junction organization|regulation of mitotic nuclear division|RNA biosynthetic process|regulation of actin cytoskeleton reorganization|negative regulation of translation|ATP binding|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|regulation of extrinsic apoptotic signaling pathway|adenyl nucleotide binding|phosphorylation|posttranscriptional regulation of gene expression|positive regulation of extrinsic apoptotic signaling pathway|nuclear body|translation|regulation of cytoskeleton organization|regulation of cell-matrix adhesion|cell-substrate junction assembly|regulation of translation|small GTPase binding|regulation of apoptotic process|focal adhesion assembly|cellular response to cytokine stimulus|leucine zipper domain binding|protein kinase activity|chromatin modification|regulation of myosin II filament organization|neurogenesis|regulation of focal adhesion assembly|cellular protein modification process|positive regulation of canonical Wnt signaling pathway|extrinsic apoptotic signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|adherens junction assembly|regulation of smooth muscle contraction|Ras GTPase binding|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand|PML body|protein serine/threonine kinase activity|Rho GTPase binding|protein autophosphorylation K08803 death-associated protein kinase[2.7.11.1] hsa05200|hsa05219 Pathways in cancer - Homo sapiens (human)|Bladder cancer - Homo sapiens (human) 19:3958453-3971123 688 720 825 329 326 416 7.2356443920012 6.88178982251647 7.82270659471261 3.10015273066044 2.81302662537902 4.10025652659834 7.31338026974343 3.33781196087927 1.13163569772443 1.23489652195928e-08 2.23840927544458e-07 UP ENSG00000077150 NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) [Source:HGNC Symbol;Acc:HGNC:7795] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0000989|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0002757|GO:0002250|GO:0045087|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043062|GO:0006952|GO:0031325|GO:0046483|GO:0001817|GO:0033256|GO:0043231|GO:0005737|GO:0000981|GO:0002218|GO:0001816|GO:0001775|GO:0009890|GO:0003682|GO:0001819|GO:0006139|GO:0009617|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0048869|GO:0002467|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0051090|GO:0007568|GO:0003713|GO:0000982|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0032479|GO:0007166|GO:0033993|GO:0002758|GO:0034097|GO:0010629|GO:0002237|GO:0051252|GO:0048536|GO:0032481|GO:0010628|GO:0006954|GO:0051091|GO:0002429|GO:0031981|GO:0033257|GO:0032606|GO:0005654|GO:0002764|GO:0002460|GO:0035556|GO:0010467|GO:0071310|GO:0030198|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0032496|GO:0005634|GO:0045089|GO:0045088|GO:0000975|GO:0045893|GO:0019221|GO:0045892|GO:0038061|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0051092|GO:0002768|GO:1902679|GO:0002221|GO:0003690|GO:0007249|GO:0002268|GO:0071345|GO:0034612|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0002223|GO:1903507|GO:0002224|GO:0006357|GO:0071356|GO:1903506|GO:0044212|GO:0033209|GO:0000122|GO:0034166|GO:0034134|GO:0038124|GO:0000976|GO:0001012|GO:0002756|GO:0034138|GO:0002755|GO:0034146|GO:0001159|GO:0034142|GO:0038123|GO:0034162|GO:0000977|GO:0000987|GO:0035666|GO:0000978 developmental process|macromolecular complex|immune system process|signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|immune response-activating signal transduction|adaptive immune response|innate immune response|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|extracellular structure organization|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cytokine production|I-kappaB/NF-kappaB complex|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|cytokine production|cell activation|negative regulation of biosynthetic process|chromatin binding|positive regulation of cytokine production|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|cellular developmental process|germinal center formation|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|aging|transcription coactivator activity|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of type I interferon production|cell surface receptor signaling pathway|response to lipid|innate immune response-activating signal transduction|response to cytokine|negative regulation of gene expression|response to molecule of bacterial origin|regulation of RNA metabolic process|spleen development|positive regulation of type I interferon production|positive regulation of gene expression|inflammatory response|positive regulation of sequence-specific DNA binding transcription factor activity|immune response-activating cell surface receptor signaling pathway|nuclear lumen|Bcl3/NF-kappaB2 complex|type I interferon production|nucleoplasm|immune response-regulating signaling pathway|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|intracellular signal transduction|gene expression|cellular response to organic substance|extracellular matrix organization|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|positive regulation of innate immune response|regulation of innate immune response|regulatory region DNA binding|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|negative regulation of transcription, DNA-templated|NIK/NF-kappaB signaling|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|negative regulation of RNA biosynthetic process|pattern recognition receptor signaling pathway|double-stranded DNA binding|I-kappaB kinase/NF-kappaB signaling|follicular dendritic cell differentiation|cellular response to cytokine stimulus|response to tumor necrosis factor|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|stimulatory C-type lectin receptor signaling pathway|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|tumor necrosis factor-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|core promoter proximal region DNA binding|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|TRIF-dependent toll-like receptor signaling pathway|RNA polymerase II core promoter proximal region sequence-specific DNA binding K04469 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2[-] hsa05200|hsa05166|hsa04010|hsa05203|hsa05169|hsa04380|hsa04064|hsa05134 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Legionellosis - Homo sapiens (human) 10:102394110-102402529 1799 1940 3188 1036 1128 1079 18.6810936727357 18.3085068381301 29.8472044400437 9.63891943089535 9.61055104808691 10.5007743525923 22.2789349836365 9.91674827719152 1.1677412276101 1.24679480389504e-08 2.25860510166762e-07 UP ENSG00000175591 P2RY2 purinergic receptor P2Y, G-protein coupled, 2 [Source:HGNC Symbol;Acc:HGNC:8541] GO:0040011|GO:0032502|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0004872|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0006950|GO:0044702|GO:0043167|GO:0019953|GO:0045177|GO:0038023|GO:0048870|GO:0040017|GO:0016043|GO:0051707|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0032504|GO:0031224|GO:0050793|GO:0005622|GO:0005886|GO:0012505|GO:0048856|GO:0048609|GO:0060405|GO:0051272|GO:0007618|GO:0043084|GO:0045595|GO:0048468|GO:0016323|GO:0006810|GO:0051130|GO:0016324|GO:0007275|GO:0050877|GO:0030279|GO:0043168|GO:0001882|GO:0043270|GO:0051128|GO:2000147|GO:0001817|GO:0005887|GO:0045597|GO:0043231|GO:0010243|GO:0004888|GO:0005737|GO:0001816|GO:0009611|GO:0006928|GO:0042592|GO:0070255|GO:0070257|GO:0060406|GO:0019725|GO:0001819|GO:0031226|GO:0009617|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0030278|GO:0001503|GO:0051047|GO:0000166|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0010876|GO:0010033|GO:0050878|GO:0003013|GO:0032370|GO:0005768|GO:0007568|GO:0005829|GO:0031175|GO:0007186|GO:0031344|GO:0035150|GO:0007166|GO:0014074|GO:0033993|GO:0035639|GO:0007589|GO:0034097|GO:2000193|GO:0002237|GO:0010720|GO:0032642|GO:0005769|GO:0048878|GO:0001883|GO:0031346|GO:0005773|GO:0009790|GO:0071417|GO:0030334|GO:0042060|GO:0071219|GO:0006811|GO:0032549|GO:0055082|GO:0032602|GO:0007600|GO:0051046|GO:0050769|GO:0032368|GO:0006869|GO:0070254|GO:0070848|GO:0005739|GO:0007620|GO:0043269|GO:0014070|GO:0007399|GO:0046903|GO:0071310|GO:0017076|GO:0032305|GO:0030154|GO:0030335|GO:0008015|GO:0004930|GO:0032496|GO:0051960|GO:0032722|GO:0048666|GO:0030182|GO:0071415|GO:0006820|GO:0010975|GO:0015711|GO:0007200|GO:0009792|GO:0070555|GO:0042312|GO:0019233|GO:0000323|GO:0032308|GO:0005524|GO:0014909|GO:0030554|GO:0001614|GO:0014910|GO:0015908|GO:0071407|GO:0046942|GO:0014911|GO:0071345|GO:0044070|GO:0050801|GO:2000191|GO:0022008|GO:0050767|GO:0071396|GO:0046717|GO:0010976|GO:0006873|GO:0071222|GO:0050880|GO:0045666|GO:0035590|GO:0015732|GO:0015718|GO:0071347|GO:0005764|GO:0035589|GO:0048699|GO:0015065|GO:0042311|GO:0043009|GO:0045028|GO:0045664|GO:0030003|GO:0045030|GO:0055065|GO:0006875|GO:0001701|GO:0006874|GO:0055074|GO:0051480|GO:0007204 locomotion|developmental process|signal transducer activity|reproduction|signaling|cell|membrane|cellular process|reproductive process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|response to stress|single organism reproductive process|ion binding|sexual reproduction|apical part of cell|signaling receptor activity|cell motility|positive regulation of locomotion|cellular component organization|response to other organism|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|multicellular organism reproduction|intrinsic component of membrane|regulation of developmental process|intracellular|plasma membrane|endomembrane system|anatomical structure development|multicellular organismal reproductive process|regulation of penile erection|positive regulation of cellular component movement|mating|penile erection|regulation of cell differentiation|cell development|basolateral plasma membrane|transport|positive regulation of cellular component organization|apical plasma membrane|multicellular organism development|neurological system process|negative regulation of ossification|anion binding|nucleoside binding|positive regulation of ion transport|regulation of cellular component organization|positive regulation of cell motility|regulation of cytokine production|integral component of plasma membrane|positive regulation of cell differentiation|intracellular membrane-bounded organelle|response to organonitrogen compound|transmembrane signaling receptor activity|cytoplasm|cytokine production|response to wounding|movement of cell or subcellular component|homeostatic process|regulation of mucus secretion|positive regulation of mucus secretion|positive regulation of penile erection|cellular homeostasis|positive regulation of cytokine production|intrinsic component of plasma membrane|response to bacterium|cell communication|regulation of cellular component movement|cell migration|signal transduction|regulation of ossification|ossification|positive regulation of secretion|nucleotide binding|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|lipid localization|response to organic substance|regulation of body fluid levels|circulatory system process|positive regulation of lipid transport|endosome|aging|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|regulation of cell projection organization|regulation of tube size|cell surface receptor signaling pathway|response to purine-containing compound|response to lipid|purine ribonucleoside triphosphate binding|body fluid secretion|response to cytokine|positive regulation of fatty acid transport|response to molecule of bacterial origin|positive regulation of cell development|regulation of chemokine production|early endosome|chemical homeostasis|purine nucleoside binding|positive regulation of cell projection organization|vacuole|embryo development|cellular response to organonitrogen compound|regulation of cell migration|wound healing|cellular response to molecule of bacterial origin|ion transport|ribonucleoside binding|cellular chemical homeostasis|chemokine production|sensory perception|regulation of secretion|positive regulation of neurogenesis|regulation of lipid transport|lipid transport|mucus secretion|response to growth factor|mitochondrion|copulation|regulation of ion transport|response to organic cyclic compound|nervous system development|secretion|cellular response to organic substance|purine nucleotide binding|positive regulation of icosanoid secretion|cell differentiation|positive regulation of cell migration|blood circulation|G-protein coupled receptor activity|response to lipopolysaccharide|regulation of nervous system development|positive regulation of chemokine production|neuron development|neuron differentiation|cellular response to purine-containing compound|anion transport|regulation of neuron projection development|organic anion transport|phospholipase C-activating G-protein coupled receptor signaling pathway|embryo development ending in birth or egg hatching|response to interleukin-1|regulation of vasodilation|sensory perception of pain|lytic vacuole|positive regulation of prostaglandin secretion|ATP binding|smooth muscle cell migration|adenyl nucleotide binding|purinergic nucleotide receptor activity|regulation of smooth muscle cell migration|fatty acid transport|cellular response to organic cyclic compound|carboxylic acid transport|positive regulation of smooth muscle cell migration|cellular response to cytokine stimulus|regulation of anion transport|ion homeostasis|regulation of fatty acid transport|neurogenesis|regulation of neurogenesis|cellular response to lipid|acid secretion|positive regulation of neuron projection development|cellular ion homeostasis|cellular response to lipopolysaccharide|regulation of blood vessel size|positive regulation of neuron differentiation|purinergic nucleotide receptor signaling pathway|prostaglandin transport|monocarboxylic acid transport|cellular response to interleukin-1|lysosome|G-protein coupled purinergic nucleotide receptor signaling pathway|generation of neurons|uridine nucleotide receptor activity|vasodilation|chordate embryonic development|G-protein coupled purinergic nucleotide receptor activity|regulation of neuron differentiation|cellular cation homeostasis|UTP-activated nucleotide receptor activity|metal ion homeostasis|cellular metal ion homeostasis|in utero embryonic development|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04269 purinergic receptor P2Y, G protein-coupled, 2[-] hsa04080|hsa04750 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human) 11:73218298-73236352 165 177 195 495 498 438 1.78165182483787 1.73696884332975 1.89840020939816 4.7889580353968 4.4119968320847 4.43242609471247 1.80567362585526 4.54446032073132 -1.33157182640114 1.27548191080853e-08 2.30917143512904e-07 DOWN ENSG00000180228 PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator [Source:HGNC Symbol;Acc:HGNC:9438] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0042802|GO:0042127|GO:0006725|GO:1901360|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0008047|GO:0016772|GO:0046483|GO:0033554|GO:0010942|GO:0043231|GO:0019899|GO:0005737|GO:0007423|GO:0009887|GO:0009615|GO:0009966|GO:0046983|GO:0048598|GO:0048568|GO:0009890|GO:0006979|GO:0016458|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0008285|GO:0050790|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:1902533|GO:2001235|GO:0032268|GO:0005829|GO:0048705|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0043412|GO:0031047|GO:0010629|GO:0043583|GO:0009790|GO:0042474|GO:0036211|GO:0032269|GO:0043331|GO:0031981|GO:0034599|GO:0048471|GO:0005654|GO:0016301|GO:0012501|GO:0014070|GO:0006796|GO:0043603|GO:0035556|GO:0044267|GO:0010467|GO:0048562|GO:0071310|GO:0051246|GO:0009059|GO:0001501|GO:0042473|GO:0043068|GO:1902531|GO:0016070|GO:0005634|GO:0042803|GO:0043067|GO:0016441|GO:0097190|GO:0097193|GO:0043043|GO:2001242|GO:0043065|GO:2001244|GO:0006396|GO:0017148|GO:0034660|GO:0071359|GO:0016310|GO:0010608|GO:0071407|GO:0006412|GO:0040029|GO:0042471|GO:0003725|GO:0030422|GO:0006417|GO:0042981|GO:0035196|GO:0044822|GO:0006464|GO:0035194|GO:0006915|GO:0016246|GO:0006468|GO:0031054|GO:0035195 developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|enzyme activator activity|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|sensory organ development|organ morphogenesis|response to virus|regulation of signal transduction|protein dimerization activity|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|response to oxidative stress|gene silencing|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|cell death|negative regulation of cell proliferation|regulation of catalytic activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cytosol|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|macromolecule modification|gene silencing by RNA|negative regulation of gene expression|ear development|embryo development|middle ear morphogenesis|protein modification process|negative regulation of cellular protein metabolic process|response to dsRNA|nuclear lumen|cellular response to oxidative stress|perinuclear region of cytoplasm|nucleoplasm|kinase activity|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|embryonic organ morphogenesis|cellular response to organic substance|regulation of protein metabolic process|macromolecule biosynthetic process|skeletal system development|outer ear morphogenesis|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|nucleus|protein homodimerization activity|regulation of programmed cell death|posttranscriptional gene silencing|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|peptide biosynthetic process|regulation of intrinsic apoptotic signaling pathway|positive regulation of apoptotic process|positive regulation of intrinsic apoptotic signaling pathway|RNA processing|negative regulation of translation|ncRNA metabolic process|cellular response to dsRNA|phosphorylation|posttranscriptional regulation of gene expression|cellular response to organic cyclic compound|translation|regulation of gene expression, epigenetic|ear morphogenesis|double-stranded RNA binding|production of siRNA involved in RNA interference|regulation of translation|regulation of apoptotic process|production of miRNAs involved in gene silencing by miRNA|poly(A) RNA binding|cellular protein modification process|posttranscriptional gene silencing by RNA|apoptotic process|RNA interference|protein phosphorylation|pre-miRNA processing|gene silencing by miRNA - - - - 2:178431414-178451512 1590 1727 1293 695 827 531 12.8128958421674 12.6480203706815 9.39426428688244 5.0180207090188 5.46793573600938 4.01027265332007 11.6183934999104 4.83207636611608 1.26569543770481 1.27931659882277e-08 2.31471016613667e-07 UP ENSG00000254851 RP11-109L13.1 - - - - - - - 11:117135528-117138582 4 4 9 34 56 32 0.344202252789124 0.312833586759462 0.69825923819167 2.62151444090065 3.95394870115491 2.58081012054573 0.451765025913419 3.05209108753376 -2.75615352734017 1.28021458124017e-08 2.31493192661079e-07 DOWN ENSG00000157353 FUK fucokinase [Source:HGNC Symbol;Acc:HGNC:29500] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043167|GO:0044237|GO:0005622|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0005737|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0016301|GO:0006796|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0050201 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|ion binding|cellular metabolic process|intracellular|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cytoplasm|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|fucokinase activity K05305 fucokinase[2.7.1.52] hsa01100 Metabolic pathways - Homo sapiens (human) 16:70454421-70480274 105 97 140 307 341 354 0.632064381310209 0.530669621847299 0.759826996381472 1.65579512459125 1.68419851654931 1.99711646389491 0.640853666512993 1.77903670167849 -1.47302940142021 1.29104495756037e-08 2.33310267330553e-07 DOWN ENSG00000136141 LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20309] GO:0005488|GO:0005515 binding|protein binding - - - - 13:46553168-46753040 124 132 218 438 499 440 0.878101849160662 0.849526866997414 1.39185920447641 2.7790421131858 2.89929467159588 2.92015165053728 1.03982930687816 2.86616281177299 -1.46277384163642 1.30201291647309e-08 2.35007821090614e-07 DOWN ENSG00000196505 GDAP2 ganglioside induced differentiation associated protein 2 [Source:HGNC Symbol;Acc:HGNC:18010] GO:0005623|GO:0016020|GO:0050896|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0031090|GO:0043231|GO:0005774|GO:0005737|GO:0010033|GO:0033993|GO:0005773|GO:0032526|GO:0000323|GO:0005765|GO:0005764 cell|membrane|response to stimulus|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|organelle membrane|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|response to organic substance|response to lipid|vacuole|response to retinoic acid|lytic vacuole|lysosomal membrane|lysosome - - - - 1:117863485-117929630 493 608 920 1636 1883 1670 2.95011165947833 3.30655109664072 4.96356252642251 8.77147012631073 9.24506073986988 9.36562783018513 3.74007509418052 9.12738623212191 -1.28713454416521 1.30163771091253e-08 2.35007821090614e-07 DOWN ENSG00000130810 PPAN peter pan homolog (Drosophila) [Source:HGNC Symbol;Acc:HGNC:9227] GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0003676|GO:0022607|GO:0043231|GO:0030529|GO:0022613|GO:0006996|GO:0005730|GO:0003723|GO:0030684|GO:0042254|GO:0022618|GO:0031981|GO:0070925|GO:0042273|GO:0005634|GO:0030687|GO:0034622|GO:0042255|GO:0019843|GO:0000027|GO:0044822 macromolecular complex|cell|cellular process|binding|organic cyclic compound binding|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|nucleic acid binding|cellular component assembly|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|ribonucleoprotein complex biogenesis|organelle organization|nucleolus|RNA binding|preribosome|ribosome biogenesis|ribonucleoprotein complex assembly|nuclear lumen|organelle assembly|ribosomal large subunit biogenesis|nucleus|preribosome, large subunit precursor|cellular macromolecular complex assembly|ribosome assembly|rRNA binding|ribosomal large subunit assembly|poly(A) RNA binding - - - - 19:10106289-10111634 918 1053 880 477 524 382 12.6163704663036 13.1522479819766 10.9040639777202 5.87364928330551 5.90868386037338 4.92021138295248 12.2242274753335 5.56751484221046 1.13463789106814 1.30332924034734e-08 2.3510326973613e-07 UP ENSG00000162929 KIAA1841 KIAA1841 [Source:HGNC Symbol;Acc:HGNC:29387] GO:0005488|GO:0097159|GO:0003676|GO:0003677 binding|organic cyclic compound binding|nucleic acid binding|DNA binding - - - - 2:61065871-61138034 100 122 127 310 333 355 0.458407595072322 0.508265883847222 0.524890090359959 1.27324367351424 1.25245838321191 1.52513779486792 0.497187856426501 1.35027995053136 -1.44139558423027 1.32295043458703e-08 2.38498564457496e-07 DOWN ENSG00000169131 ZNF354A zinc finger protein 354A [Source:HGNC Symbol;Acc:HGNC:11628] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0009605|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:0001822|GO:1901360|GO:0009991|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0010243|GO:0009890|GO:0006139|GO:0001666|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0007568|GO:0007584|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0001655|GO:0010629|GO:0051252|GO:0043200|GO:0072001|GO:0033273|GO:0007600|GO:0007569|GO:0031981|GO:0014070|GO:0010467|GO:0006997|GO:0009059|GO:0016070|GO:0031667|GO:0005634|GO:0050954|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0007000|GO:0006351|GO:0006355|GO:0007576|GO:0051593|GO:0006366|GO:1903507|GO:0007605|GO:0006357|GO:1903506|GO:0000122 developmental process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|response to external stimulus|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|kidney development|organic cyclic compound metabolic process|response to extracellular stimulus|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|response to hypoxia|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|aging|response to nutrient|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|urogenital system development|negative regulation of gene expression|regulation of RNA metabolic process|response to amino acid|renal system development|response to vitamin|sensory perception|cell aging|nuclear lumen|response to organic cyclic compound|gene expression|nucleus organization|macromolecule biosynthetic process|RNA metabolic process|response to nutrient levels|nucleus|sensory perception of mechanical stimulus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|nucleolus organization|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleolar fragmentation|response to folic acid|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|sensory perception of sound|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 5:178711592-178730702 335 375 325 105 152 158 7.21584558261026 7.34097707195765 6.31160156453262 2.02642055723979 2.68628945913276 3.18955164066294 6.95614140636684 2.63408721901183 1.40098414402724 1.3248032531173e-08 2.38688450926759e-07 UP ENSG00000130635 COL5A1 collagen, type V, alpha 1 [Source:HGNC Symbol;Acc:HGNC:2209] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0005604|GO:1903561|GO:0005201|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0005578|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0048870|GO:0009653|GO:0016043|GO:0005583|GO:0007155|GO:0043227|GO:0009605|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0007507|GO:0008201|GO:0006935|GO:0045595|GO:0009888|GO:0048468|GO:0019838|GO:0001568|GO:0007275|GO:0045596|GO:0048513|GO:0005102|GO:0043168|GO:0043062|GO:0031982|GO:0051128|GO:0043231|GO:0043169|GO:0005737|GO:0045992|GO:0009611|GO:0007423|GO:0006928|GO:0009887|GO:0032403|GO:0048729|GO:0048598|GO:0050839|GO:0044236|GO:0001704|GO:0061024|GO:0016477|GO:0005783|GO:0070062|GO:0005588|GO:0030030|GO:0001948|GO:0048869|GO:0005581|GO:0005539|GO:0010256|GO:1903225|GO:0000902|GO:0031175|GO:0030574|GO:0044259|GO:0046872|GO:0001654|GO:0002009|GO:0001944|GO:0022617|GO:0072358|GO:0032964|GO:0003007|GO:0007492|GO:0000904|GO:0009790|GO:0044319|GO:0007009|GO:0043394|GO:0007369|GO:0042060|GO:0005178|GO:0001706|GO:0043588|GO:0060429|GO:0032990|GO:0005788|GO:0007399|GO:0097485|GO:0030198|GO:0010470|GO:0009059|GO:0030154|GO:0048858|GO:0061448|GO:0072359|GO:0045995|GO:0048407|GO:0048666|GO:0030182|GO:0007411|GO:0035989|GO:0002011|GO:0035987|GO:0045112|GO:0061564|GO:0030199|GO:0097435|GO:0022008|GO:0048667|GO:0048812|GO:0048592|GO:0032963|GO:0035313|GO:0007409|GO:0048699|GO:0043206 locomotion|developmental process|extracellular matrix|macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|basement membrane|extracellular vesicle|extracellular matrix structural constituent|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|response to stress|organic substance metabolic process|catabolic process|ion binding|cell motility|anatomical structure morphogenesis|cellular component organization|fibrillar collagen trimer|cell adhesion|membrane-bounded organelle|response to external stimulus|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|heart development|heparin binding|chemotaxis|regulation of cell differentiation|tissue development|cell development|growth factor binding|blood vessel development|multicellular organism development|negative regulation of cell differentiation|animal organ development|receptor binding|anion binding|extracellular structure organization|vesicle|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|cytoplasm|negative regulation of embryonic development|response to wounding|sensory organ development|movement of cell or subcellular component|organ morphogenesis|protein complex binding|tissue morphogenesis|embryonic morphogenesis|cell adhesion molecule binding|multicellular organism metabolic process|formation of primary germ layer|membrane organization|cell migration|endoplasmic reticulum|extracellular exosome|collagen type V trimer|cell projection organization|glycoprotein binding|cellular developmental process|collagen trimer|glycosaminoglycan binding|endomembrane system organization|negative regulation of endodermal cell differentiation|cell morphogenesis|neuron projection development|collagen catabolic process|multicellular organismal macromolecule metabolic process|metal ion binding|eye development|morphogenesis of an epithelium|vasculature development|extracellular matrix disassembly|cardiovascular system development|collagen biosynthetic process|heart morphogenesis|endoderm development|cell morphogenesis involved in differentiation|embryo development|wound healing, spreading of cells|plasma membrane organization|proteoglycan binding|gastrulation|wound healing|integrin binding|endoderm formation|skin development|epithelium development|cell part morphogenesis|endoplasmic reticulum lumen|nervous system development|neuron projection guidance|extracellular matrix organization|regulation of gastrulation|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|connective tissue development|circulatory system development|regulation of embryonic development|platelet-derived growth factor binding|neuron development|neuron differentiation|axon guidance|tendon development|morphogenesis of an epithelial sheet|endodermal cell differentiation|integrin biosynthetic process|axon development|collagen fibril organization|fibril organization|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|eye morphogenesis|collagen metabolic process|wound healing, spreading of epidermal cells|axonogenesis|generation of neurons|extracellular fibril organization K19721 collagen, type V/XI/XXIV/XXVII, alpha[-] hsa04974 Protein digestion and absorption - Homo sapiens (human) 9:134641774-134844843 2 1 5 18 31 53 0.00920051547192574 0.00418299471494143 0.0207373104712993 0.0741929779338566 0.117013818781139 0.228509859880429 0.0113736068860555 0.139905552198475 -3.62069146697483 1.32860499672253e-08 2.39229032401414e-07 DOWN ENSG00000171055 FEZ2 fasciculation and elongation protein zeta 2 (zygin II) [Source:HGNC Symbol;Acc:HGNC:3660] GO:0040011|GO:0032502|GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0009056|GO:0044237|GO:0006914|GO:0009653|GO:0016043|GO:0009605|GO:0005515|GO:0048856|GO:0019222|GO:0010507|GO:0010506|GO:0006935|GO:0048468|GO:1902115|GO:0009991|GO:0007275|GO:0051128|GO:0033554|GO:0022607|GO:0006928|GO:0010646|GO:0007154|GO:0007165|GO:0016236|GO:0030030|GO:0048869|GO:0031324|GO:0031323|GO:0006996|GO:0000902|GO:0031175|GO:2000785|GO:0000904|GO:0016241|GO:0070925|GO:0033043|GO:0032990|GO:0007399|GO:0097485|GO:0016242|GO:0030154|GO:0048858|GO:0000045|GO:0031667|GO:0007033|GO:0048666|GO:0030182|GO:0007411|GO:1902902|GO:0044088|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699 locomotion|developmental process|signaling|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|catabolic process|cellular metabolic process|autophagy|anatomical structure morphogenesis|cellular component organization|response to external stimulus|protein binding|anatomical structure development|regulation of metabolic process|negative regulation of autophagy|regulation of autophagy|chemotaxis|cell development|regulation of organelle assembly|response to extracellular stimulus|multicellular organism development|regulation of cellular component organization|cellular response to stress|cellular component assembly|movement of cell or subcellular component|regulation of cell communication|cell communication|signal transduction|macroautophagy|cell projection organization|cellular developmental process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|cell morphogenesis|neuron projection development|regulation of autophagosome assembly|cell morphogenesis involved in differentiation|regulation of macroautophagy|organelle assembly|regulation of organelle organization|cell part morphogenesis|nervous system development|neuron projection guidance|negative regulation of macroautophagy|cell differentiation|cell projection morphogenesis|autophagosome assembly|response to nutrient levels|vacuole organization|neuron development|neuron differentiation|axon guidance|negative regulation of autophagosome assembly|regulation of vacuole organization|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons - - - - 2:36531805-36646087 243 301 378 676 874 776 1.19426693936395 1.34443884877772 1.67494635722741 2.9767235213884 3.52430689642022 3.57425317544266 1.40455071512303 3.35842786441709 -1.25767732380355 1.32955138961305e-08 2.39255136742062e-07 DOWN ENSG00000183354 KIAA2026 KIAA2026 [Source:HGNC Symbol;Acc:HGNC:23378] GO:0005488|GO:0005515 binding|protein binding - - - - 9:5881596-6007901 65 60 90 221 213 274 0.250308318632036 0.209986288025705 0.31247706369409 0.762517695003546 0.67298820356934 0.988869876939823 0.257590556783944 0.808125258504236 -1.64949922089145 1.3473359585925e-08 2.42309444023015e-07 DOWN ENSG00000064995 TAF11 TATA-box binding protein associated factor 11 [Source:HGNC Symbol;Acc:HGNC:11544] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0019222|GO:0016032|GO:0047485|GO:0003712|GO:0006725|GO:1901360|GO:0051702|GO:0005102|GO:0034641|GO:0048524|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0005667|GO:0046983|GO:0006139|GO:0008134|GO:0044249|GO:0050792|GO:0031323|GO:0005794|GO:0003713|GO:0042809|GO:0010468|GO:0034645|GO:0044798|GO:0051427|GO:0046982|GO:0051252|GO:0010628|GO:0019083|GO:0031981|GO:1990234|GO:0005654|GO:0046966|GO:1903902|GO:0010467|GO:0019058|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0034622|GO:0046782|GO:0032774|GO:2001141|GO:0035257|GO:0065004|GO:0005669|GO:0090575|GO:0050434|GO:0016591|GO:0006351|GO:0006355|GO:0006366|GO:0006352|GO:0043923|GO:1903506|GO:0006354|GO:0006367|GO:0051123|GO:0006368 macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|regulation of metabolic process|viral process|protein N-terminus binding|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|interaction with symbiont|receptor binding|cellular nitrogen compound metabolic process|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|transcription factor complex|protein dimerization activity|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|regulation of viral process|regulation of cellular metabolic process|Golgi apparatus|transcription coactivator activity|vitamin D receptor binding|regulation of gene expression|cellular macromolecule biosynthetic process|nuclear transcription factor complex|hormone receptor binding|protein heterodimerization activity|regulation of RNA metabolic process|positive regulation of gene expression|viral transcription|nuclear lumen|transferase complex|nucleoplasm|thyroid hormone receptor binding|positive regulation of viral life cycle|gene expression|viral life cycle|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|cellular macromolecular complex assembly|regulation of viral transcription|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|protein-DNA complex assembly|transcription factor TFIID complex|RNA polymerase II transcription factor complex|positive regulation of viral transcription|DNA-directed RNA polymerase II, holoenzyme|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|positive regulation by host of viral transcription|regulation of nucleic acid-templated transcription|DNA-templated transcription, elongation|transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter K03135 transcription initiation factor TFIID subunit 11[-] hsa03022 Basal transcription factors - Homo sapiens (human) 6:34877778-34888089 810 965 921 474 500 365 30.722164303469 33.2639880859387 31.4949512337877 16.1080419540198 15.5598174696014 12.9744392939058 31.8270345410651 14.8807662391757 1.09680392576748 1.35094710576275e-08 2.42812612254311e-07 UP ENSG00000115295 CLIP4 CAP-Gly domain containing linker protein family member 4 [Source:HGNC Symbol;Acc:HGNC:26108] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 2:29097705-29189643 434 562 697 1233 1422 1738 2.92769636280559 3.44550110792989 4.23918883707027 7.45240609941134 7.87052081232625 10.9878963761498 3.53746210260192 8.7702744292958 -1.30990729431862 1.35178888261339e-08 2.42817721429243e-07 DOWN ENSG00000091972 CD200 CD200 molecule [Source:HGNC Symbol;Acc:HGNC:7203] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0004872|GO:0006955|GO:0005911|GO:0007155|GO:0071944|GO:0031224|GO:0002682|GO:0005515|GO:0005886|GO:0042802|GO:0005102|GO:0005912|GO:0098609|GO:0005887|GO:0046983|GO:0050839|GO:0008037|GO:0031226|GO:0050776|GO:0005913|GO:0016021|GO:0098742|GO:0042803|GO:0007157|GO:0007156 immune system process|cell|membrane|cellular process|cell junction|response to stimulus|binding|receptor activity|immune response|cell-cell junction|cell adhesion|cell periphery|intrinsic component of membrane|regulation of immune system process|protein binding|plasma membrane|identical protein binding|receptor binding|adherens junction|cell-cell adhesion|integral component of plasma membrane|protein dimerization activity|cell adhesion molecule binding|cell recognition|intrinsic component of plasma membrane|regulation of immune response|cell-cell adherens junction|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|protein homodimerization activity|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|homophilic cell adhesion via plasma membrane adhesion molecules - - - - 3:112332347-112362812 15 15 24 76 72 78 0.151555002813445 0.137743173238668 0.218626838961204 0.688009204896915 0.596879106449999 0.738597741781978 0.169308338337772 0.674495351042964 -1.99415547255702 1.38825500016147e-08 2.49218068399401e-07 DOWN ENSG00000109775 UFSP2 UFM1-specific peptidase 2 [Source:HGNC Symbol;Acc:HGNC:25640] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0023051|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0012505|GO:0016788|GO:0043231|GO:0008233|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0005783|GO:0009725|GO:0019538|GO:0010033|GO:0033993|GO:0016790|GO:0006508|GO:0033143|GO:0014070|GO:0071310|GO:0009755|GO:0032870|GO:0005634|GO:0048545|GO:0030522|GO:0043401|GO:0071383|GO:0071407|GO:0030518|GO:0008234|GO:0071396|GO:0033146|GO:0030520|GO:0071567 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|regulation of signaling|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|endomembrane system|hydrolase activity, acting on ester bonds|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|endoplasmic reticulum|response to hormone|protein metabolic process|response to organic substance|response to lipid|thiolester hydrolase activity|proteolysis|regulation of intracellular steroid hormone receptor signaling pathway|response to organic cyclic compound|cellular response to organic substance|hormone-mediated signaling pathway|cellular response to hormone stimulus|nucleus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|cysteine-type peptidase activity|cellular response to lipid|regulation of intracellular estrogen receptor signaling pathway|intracellular estrogen receptor signaling pathway|UFM1 hydrolase activity - - - - 4:185399540-185425985 115 130 207 430 447 432 1.67795465640634 1.72387567456251 2.7231208018511 5.62146637086846 5.35128822398132 5.90739240046302 2.04165037760665 5.62671566510427 -1.46255722843771 1.39983426412209e-08 2.51145745920078e-07 DOWN ENSG00000112578 BYSL bystin like [Source:HGNC Symbol;Acc:HGNC:1157] GO:0032502|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0097159|GO:0008283|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0045177|GO:0009653|GO:0051707|GO:0007155|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0001824|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0005874|GO:0046483|GO:0001825|GO:0007420|GO:0043231|GO:0005737|GO:0060322|GO:0006139|GO:0009617|GO:0007565|GO:0048869|GO:0022613|GO:0010033|GO:0005730|GO:0003723|GO:0033993|GO:0034097|GO:0007417|GO:0002237|GO:0009790|GO:0042254|GO:0071219|GO:0031981|GO:0048471|GO:0070848|GO:0014070|GO:0042274|GO:0010467|GO:0007399|GO:0071310|GO:0030154|GO:0005881|GO:0016070|GO:0005856|GO:0032496|GO:0005634|GO:0001829|GO:0030182|GO:0006364|GO:0009792|GO:0030490|GO:0070555|GO:0006396|GO:0034660|GO:0071363|GO:0071407|GO:0015630|GO:0071345|GO:0044822|GO:0022008|GO:0071396|GO:0071222|GO:0071347|GO:0048699|GO:0000462|GO:0016072|GO:0043009|GO:0001701 developmental process|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|organic cyclic compound binding|cell proliferation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|apical part of cell|anatomical structure morphogenesis|response to other organism|cell adhesion|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|blastocyst development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|microtubule|heterocycle metabolic process|blastocyst formation|brain development|intracellular membrane-bounded organelle|cytoplasm|head development|nucleobase-containing compound metabolic process|response to bacterium|female pregnancy|cellular developmental process|ribonucleoprotein complex biogenesis|response to organic substance|nucleolus|RNA binding|response to lipid|response to cytokine|central nervous system development|response to molecule of bacterial origin|embryo development|ribosome biogenesis|cellular response to molecule of bacterial origin|nuclear lumen|perinuclear region of cytoplasm|response to growth factor|response to organic cyclic compound|ribosomal small subunit biogenesis|gene expression|nervous system development|cellular response to organic substance|cell differentiation|cytoplasmic microtubule|RNA metabolic process|cytoskeleton|response to lipopolysaccharide|nucleus|trophectodermal cell differentiation|neuron differentiation|rRNA processing|embryo development ending in birth or egg hatching|maturation of SSU-rRNA|response to interleukin-1|RNA processing|ncRNA metabolic process|cellular response to growth factor stimulus|cellular response to organic cyclic compound|microtubule cytoskeleton|cellular response to cytokine stimulus|poly(A) RNA binding|neurogenesis|cellular response to lipid|cellular response to lipopolysaccharide|cellular response to interleukin-1|generation of neurons|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|rRNA metabolic process|chordate embryonic development|in utero embryonic development - - - - 6:41921188-41933046 1704 1635 1064 597 635 318 26.4042986734566 23.0251678034103 14.8648656883474 8.28852545479637 8.07321451620068 4.61808251185753 21.4314440550714 6.99327416095153 1.615689092245 1.41337167279897e-08 2.5342220972817e-07 UP ENSG00000167378 IRGQ immunity-related GTPase family, Q [Source:HGNC Symbol;Acc:HGNC:24868] GO:0005488|GO:0036094|GO:0097159|GO:0043167|GO:0043168|GO:0001882|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0032561|GO:0005525|GO:0019001 binding|small molecule binding|organic cyclic compound binding|ion binding|anion binding|nucleoside binding|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|guanyl ribonucleotide binding|GTP binding|guanyl nucleotide binding - - - - 19:43584369-43596135 678 813 808 373 444 313 2.89751139144021 3.15766480571877 3.11329936238942 1.42824169554729 1.55684943631019 1.25362780467561 3.05615851984947 1.4129063121777 1.11305357067362 1.41568324971735e-08 2.5368432015043e-07 UP ENSG00000164221 CCDC112 coiled-coil domain containing 112 [Source:HGNC Symbol;Acc:HGNC:28599] GO:0005488|GO:0005515 binding|protein binding - - - - 5:115267188-115296831 256 299 436 91 123 151 2.82022325293037 2.99360438347604 4.33055543352686 0.898214168117085 1.11177333147203 1.55901212483144 3.38146102331109 1.18966654147352 1.50708947566801 1.44472233224296e-08 2.58732696501388e-07 UP ENSG00000173011 TADA2B transcriptional adaptor 2B [Source:HGNC Symbol;Acc:HGNC:30781] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0003824|GO:0097159|GO:0003700|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0003712|GO:0006725|GO:0051130|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0043169|GO:0016746|GO:0003682|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0003713|GO:0051276|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0031056|GO:0051252|GO:0006325|GO:0031058|GO:0016573|GO:0036211|GO:0031981|GO:1990234|GO:0051247|GO:0005654|GO:0016747|GO:0032270|GO:0033043|GO:0044267|GO:0010467|GO:0000123|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0010638|GO:2001252|GO:0031401|GO:0032774|GO:2001141|GO:0033044|GO:0035066|GO:0016407|GO:0016410|GO:0035065|GO:0046914|GO:0016568|GO:0070461|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0018193|GO:0008080|GO:1901985|GO:0030914|GO:0006338|GO:0008270|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402 macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|catalytic activity|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|chromatin binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|chromosome organization|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|regulation of histone modification|regulation of RNA metabolic process|chromatin organization|positive regulation of histone modification|histone acetylation|protein modification process|nuclear lumen|transferase complex|positive regulation of protein metabolic process|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|positive regulation of cellular protein metabolic process|regulation of organelle organization|cellular protein metabolic process|gene expression|histone acetyltransferase complex|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|positive regulation of organelle organization|positive regulation of chromosome organization|positive regulation of protein modification process|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of chromosome organization|positive regulation of histone acetylation|acetyltransferase activity|N-acyltransferase activity|regulation of histone acetylation|transition metal ion binding|chromatin modification|SAGA-type complex|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|N-acetyltransferase activity|positive regulation of protein acetylation|STAGA complex|chromatin remodeling|zinc ion binding|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity - - - - 4:7041899-7057952 603 625 456 245 250 226 4.01906088341996 3.78588469085803 2.74022966914258 1.46308903079922 1.36714687556801 1.41171039363282 3.51505841447352 1.41398210000002 1.31378480793152 1.45388077282261e-08 2.60216766138166e-07 UP ENSG00000164128 NPY1R neuropeptide Y receptor Y1 [Source:HGNC Symbol;Acc:HGNC:7956] GO:0032502|GO:0040007|GO:0004871|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0008021|GO:0007631|GO:0004872|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0051051|GO:0051641|GO:0038023|GO:0023051|GO:0009653|GO:0043227|GO:0071944|GO:0040008|GO:0023057|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0007626|GO:0048856|GO:0007507|GO:0060341|GO:0006810|GO:0007275|GO:0048513|GO:0050877|GO:0044281|GO:0032940|GO:0031982|GO:0005887|GO:0043231|GO:0030133|GO:0004888|GO:0005737|GO:0003012|GO:0007267|GO:0005975|GO:0009887|GO:0035264|GO:0042592|GO:0043005|GO:1903524|GO:0046883|GO:0019725|GO:0010646|GO:0031226|GO:0007154|GO:0007165|GO:0003151|GO:0048638|GO:0046888|GO:0009725|GO:0040014|GO:0008217|GO:0051048|GO:1903531|GO:0010817|GO:0016021|GO:0010033|GO:0003013|GO:0005829|GO:0007186|GO:0035150|GO:0006936|GO:0007166|GO:0033993|GO:0030424|GO:0072358|GO:0031410|GO:0048878|GO:0003007|GO:0016023|GO:0070382|GO:0045907|GO:0055082|GO:0007600|GO:0051046|GO:0009914|GO:0005996|GO:0031988|GO:0014070|GO:0046903|GO:0008528|GO:0072359|GO:0008015|GO:0004930|GO:0048545|GO:0097305|GO:0019318|GO:0007187|GO:0006939|GO:0019233|GO:0043627|GO:0019229|GO:0008188|GO:0032355|GO:0050801|GO:0007218|GO:0046879|GO:0006873|GO:0050880|GO:0007188|GO:0006006|GO:0042310|GO:0004983|GO:0030003|GO:0001601|GO:0007193|GO:0030432|GO:0055065|GO:0006875|GO:0001602|GO:0006874|GO:0055074|GO:0051480|GO:0051481 developmental process|growth|signal transducer activity|synapse|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|synaptic vesicle|feeding behavior|receptor activity|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|negative regulation of transport|cellular localization|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|regulation of growth|negative regulation of signaling|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|endomembrane system|locomotory behavior|anatomical structure development|heart development|regulation of cellular localization|transport|multicellular organism development|animal organ development|neurological system process|small molecule metabolic process|secretion by cell|vesicle|integral component of plasma membrane|intracellular membrane-bounded organelle|transport vesicle|transmembrane signaling receptor activity|cytoplasm|muscle system process|cell-cell signaling|carbohydrate metabolic process|organ morphogenesis|multicellular organism growth|homeostatic process|neuron projection|positive regulation of blood circulation|regulation of hormone secretion|cellular homeostasis|regulation of cell communication|intrinsic component of plasma membrane|cell communication|signal transduction|outflow tract morphogenesis|regulation of developmental growth|negative regulation of hormone secretion|response to hormone|regulation of multicellular organism growth|regulation of blood pressure|negative regulation of secretion|negative regulation of secretion by cell|regulation of hormone levels|integral component of membrane|response to organic substance|circulatory system process|cytosol|G-protein coupled receptor signaling pathway|regulation of tube size|muscle contraction|cell surface receptor signaling pathway|response to lipid|axon|cardiovascular system development|cytoplasmic vesicle|chemical homeostasis|heart morphogenesis|cytoplasmic, membrane-bounded vesicle|exocytic vesicle|positive regulation of vasoconstriction|cellular chemical homeostasis|sensory perception|regulation of secretion|hormone transport|monosaccharide metabolic process|membrane-bounded vesicle|response to organic cyclic compound|secretion|G-protein coupled peptide receptor activity|circulatory system development|blood circulation|G-protein coupled receptor activity|response to steroid hormone|response to alcohol|hexose metabolic process|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|smooth muscle contraction|sensory perception of pain|response to estrogen|regulation of vasoconstriction|neuropeptide receptor activity|response to estradiol|ion homeostasis|neuropeptide signaling pathway|hormone secretion|cellular ion homeostasis|regulation of blood vessel size|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|glucose metabolic process|vasoconstriction|neuropeptide Y receptor activity|cellular cation homeostasis|peptide YY receptor activity|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|peristalsis|metal ion homeostasis|cellular metal ion homeostasis|pancreatic polypeptide receptor activity|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|negative regulation of cytosolic calcium ion concentration K04204 neuropeptide Y receptor type 1[-] hsa04080|hsa04024|hsa04923 Neuroactive ligand-receptor interaction - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Regulation of lipolysis in adipocytes - Homo sapiens (human) 4:163323961-163344832 85 77 120 22 32 33 0.87482191544654 0.720231730648366 1.11351171170441 0.202868418323631 0.270218184753996 0.318305203617969 0.902855119266439 0.263797268898532 1.77506486928958 1.45695851127519e-08 2.60611380441039e-07 UP ENSG00000136270 TBRG4 transforming growth factor beta regulator 4 [Source:HGNC Symbol;Acc:HGNC:17443] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0022402|GO:0003676|GO:0015980|GO:0016772|GO:0045786|GO:0043231|GO:0005737|GO:0006091|GO:0019538|GO:0055114|GO:0003723|GO:0043412|GO:0007050|GO:0036211|GO:0005739|GO:0016301|GO:0006796|GO:0044267|GO:0045333|GO:0016773|GO:0016310|GO:0004672|GO:0044822|GO:0006464|GO:0006468 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|cell cycle process|nucleic acid binding|energy derivation by oxidation of organic compounds|transferase activity, transferring phosphorus-containing groups|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|generation of precursor metabolites and energy|protein metabolic process|oxidation-reduction process|RNA binding|macromolecule modification|cell cycle arrest|protein modification process|mitochondrion|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|cellular respiration|phosphotransferase activity, alcohol group as acceptor|phosphorylation|protein kinase activity|poly(A) RNA binding|cellular protein modification process|protein phosphorylation - - - - 7:45100100-45112047 2463 2900 2877 1487 1520 1067 15.6073530867661 16.7010140129503 16.4368613354163 8.4425471624892 7.90271758887973 6.33662773703985 16.2484094783776 7.56063082946959 1.10371998534546 1.4812351921283e-08 2.64795182190408e-07 UP ENSG00000185745 IFIT1 interferon induced protein with tetratricopeptide repeats 1 [Source:HGNC Symbol;Acc:HGNC:5407] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0044216|GO:0006955|GO:0051641|GO:0051707|GO:0009607|GO:0009605|GO:0005622|GO:0002682|GO:0005515|GO:0019222|GO:0016032|GO:0045087|GO:0006810|GO:0050688|GO:0003676|GO:0006952|GO:0048524|GO:0098542|GO:0051098|GO:0005737|GO:0042592|GO:0009615|GO:0045184|GO:0043657|GO:0008104|GO:0007154|GO:0044092|GO:0007165|GO:0051649|GO:0048525|GO:0050687|GO:0051607|GO:0050790|GO:0043086|GO:0050792|GO:0010033|GO:0051701|GO:0050689|GO:0005829|GO:0034340|GO:0003723|GO:0007166|GO:0051100|GO:0034097|GO:0048878|GO:0015031|GO:0043331|GO:0046907|GO:0051346|GO:0034613|GO:0014070|GO:1903902|GO:0019079|GO:0019058|GO:0071310|GO:0050691|GO:0043393|GO:0051097|GO:0019221|GO:0075733|GO:0071359|GO:0071357|GO:0045069|GO:0071407|GO:0006886|GO:0045070|GO:0045071|GO:0071345|GO:0043330|GO:0019060|GO:0032091|GO:0071360|GO:0060337 immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|other organism cell|immune response|cellular localization|response to other organism|response to biotic stimulus|response to external stimulus|intracellular|regulation of immune system process|protein binding|regulation of metabolic process|viral process|innate immune response|transport|regulation of defense response to virus|nucleic acid binding|defense response|positive regulation of viral process|defense response to other organism|regulation of binding|cytoplasm|homeostatic process|response to virus|establishment of protein localization|host cell|protein localization|cell communication|negative regulation of molecular function|signal transduction|establishment of localization in cell|negative regulation of viral process|negative regulation of defense response to virus|defense response to virus|regulation of catalytic activity|negative regulation of catalytic activity|regulation of viral process|response to organic substance|interaction with host|negative regulation of defense response to virus by host|cytosol|response to type I interferon|RNA binding|cell surface receptor signaling pathway|negative regulation of binding|response to cytokine|chemical homeostasis|protein transport|response to dsRNA|intracellular transport|negative regulation of hydrolase activity|cellular protein localization|response to organic cyclic compound|positive regulation of viral life cycle|viral genome replication|viral life cycle|cellular response to organic substance|regulation of defense response to virus by host|regulation of protein binding|negative regulation of helicase activity|cytokine-mediated signaling pathway|intracellular transport of virus|cellular response to dsRNA|cellular response to type I interferon|regulation of viral genome replication|cellular response to organic cyclic compound|intracellular protein transport|positive regulation of viral genome replication|negative regulation of viral genome replication|cellular response to cytokine stimulus|response to exogenous dsRNA|intracellular transport of viral protein in host cell|negative regulation of protein binding|cellular response to exogenous dsRNA|type I interferon signaling pathway K14217 interferon-induced protein with tetratricopeptide repeats 1[-] hsa05168|hsa05160 Herpes simplex infection - Homo sapiens (human)|Hepatitis C - Homo sapiens (human) 10:89392546-89406486 150 199 183 69 63 72 1.67861070540532 2.02392082556442 1.84639821987134 0.691839666878893 0.578455001011392 0.755123841354045 1.84964325028036 0.675139503081443 1.45398949790953 1.49521492978373e-08 2.67134329825037e-07 UP ENSG00000168394 TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) [Source:HGNC Symbol;Acc:HGNC:43] GO:0032991|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0002683|GO:0033218|GO:0097159|GO:0022857|GO:0050794|GO:0001909|GO:0019882|GO:0043229|GO:0006950|GO:0042175|GO:0044216|GO:0043167|GO:0006955|GO:0003823|GO:0051641|GO:0043227|GO:0016787|GO:0031224|GO:0002684|GO:0042267|GO:0005622|GO:0002682|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0042802|GO:0016032|GO:0042605|GO:0002250|GO:0042277|GO:0045087|GO:0019884|GO:0006810|GO:0015197|GO:0005102|GO:0043168|GO:0006952|GO:0001882|GO:0016817|GO:0043231|GO:0031227|GO:0005737|GO:0001910|GO:0042269|GO:0042824|GO:0042592|GO:0046983|GO:0045184|GO:0043657|GO:0022891|GO:0050776|GO:0030176|GO:0008104|GO:0055085|GO:0005783|GO:0051649|GO:0050777|GO:0045953|GO:0019883|GO:0048002|GO:0000166|GO:0016021|GO:0046977|GO:0050792|GO:0031301|GO:0046980|GO:0002443|GO:0051701|GO:0042825|GO:0016820|GO:0046979|GO:0035639|GO:0046982|GO:0048878|GO:0045824|GO:0001883|GO:0015031|GO:0002228|GO:0046978|GO:0016818|GO:0046907|GO:0042886|GO:0032549|GO:0043531|GO:0042287|GO:0042270|GO:0005739|GO:0002474|GO:0034613|GO:0019058|GO:0017076|GO:0042803|GO:0045088|GO:0002476|GO:0023029|GO:0042590|GO:0002591|GO:0075733|GO:0005524|GO:0046967|GO:0030554|GO:0015833|GO:0006886|GO:0002715|GO:0019885|GO:0042288|GO:0042626|GO:0019060|GO:0015440|GO:0016462|GO:0017111|GO:0002479|GO:0002481|GO:0016887|GO:0002485|GO:0002489|GO:0042623|GO:0043492 macromolecular complex|transporter activity|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|negative regulation of immune system process|amide binding|organic cyclic compound binding|transmembrane transporter activity|regulation of cellular process|leukocyte mediated cytotoxicity|antigen processing and presentation|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|other organism cell|ion binding|immune response|antigen binding|cellular localization|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|positive regulation of immune system process|natural killer cell mediated cytotoxicity|intracellular|regulation of immune system process|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|identical protein binding|viral process|peptide antigen binding|adaptive immune response|peptide binding|innate immune response|antigen processing and presentation of exogenous antigen|transport|peptide transporter activity|receptor binding|anion binding|defense response|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cytoplasm|regulation of leukocyte mediated cytotoxicity|regulation of natural killer cell mediated cytotoxicity|MHC class I peptide loading complex|homeostatic process|protein dimerization activity|establishment of protein localization|host cell|substrate-specific transmembrane transporter activity|regulation of immune response|integral component of endoplasmic reticulum membrane|protein localization|transmembrane transport|endoplasmic reticulum|establishment of localization in cell|negative regulation of immune response|negative regulation of natural killer cell mediated cytotoxicity|antigen processing and presentation of endogenous antigen|antigen processing and presentation of peptide antigen|nucleotide binding|integral component of membrane|TAP binding|regulation of viral process|integral component of organelle membrane|tapasin binding|leukocyte mediated immunity|interaction with host|TAP complex|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|TAP2 binding|purine ribonucleoside triphosphate binding|protein heterodimerization activity|chemical homeostasis|negative regulation of innate immune response|purine nucleoside binding|protein transport|natural killer cell mediated immunity|TAP1 binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|amide transport|ribonucleoside binding|ADP binding|MHC protein binding|protection from natural killer cell mediated cytotoxicity|mitochondrion|antigen processing and presentation of peptide antigen via MHC class I|cellular protein localization|viral life cycle|purine nucleotide binding|protein homodimerization activity|regulation of innate immune response|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|MHC class Ib protein binding|antigen processing and presentation of exogenous peptide antigen via MHC class I|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|intracellular transport of virus|ATP binding|cytosol to ER transport|adenyl nucleotide binding|peptide transport|intracellular protein transport|regulation of natural killer cell mediated immunity|antigen processing and presentation of endogenous peptide antigen via MHC class I|MHC class I protein binding|ATPase activity, coupled to transmembrane movement of substances|intracellular transport of viral protein in host cell|peptide-transporting ATPase activity|pyrophosphatase activity|nucleoside-triphosphatase activity|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|ATPase activity, coupled|ATPase activity, coupled to movement of substances K05653 ATP-binding cassette, subfamily B (MDR/TAP), member 2[-] hsa05168|hsa04145|hsa04612|hsa02010|hsa05340 Herpes simplex infection - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Antigen processing and presentation - Homo sapiens (human)|ABC transporters - Homo sapiens (human)|Primary immunodeficiency - Homo sapiens (human) 6:32845209-32853978 1144 1243 1304 605 655 655 14.7642716450991 14.5793117603096 15.1732245678516 6.99582218642366 6.93578249358724 7.92238515091886 14.8389359910868 7.28466327697659 1.02645345641935 1.50622957113886e-08 2.68941253688872e-07 UP ENSG00000079459 FDFT1 farnesyl-diphosphate farnesyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:3629] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:1901360|GO:0044281|GO:0019637|GO:0043231|GO:0005737|GO:0006629|GO:0005783|GO:0016765|GO:0016021|GO:0044249|GO:0055114|GO:0004659|GO:0006720|GO:0006066|GO:0008299|GO:0008202|GO:0006796|GO:0008610|GO:0006644|GO:0004311|GO:0006694|GO:0016125|GO:0045338|GO:0051996|GO:0016126|GO:0008203|GO:0004310|GO:0006695 cell|membrane|cellular process|metabolic process|catalytic activity|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|organic cyclic compound metabolic process|small molecule metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring alkyl or aryl (other than methyl) groups|integral component of membrane|cellular biosynthetic process|oxidation-reduction process|prenyltransferase activity|isoprenoid metabolic process|alcohol metabolic process|isoprenoid biosynthetic process|steroid metabolic process|phosphate-containing compound metabolic process|lipid biosynthetic process|phospholipid metabolic process|farnesyltranstransferase activity|steroid biosynthetic process|sterol metabolic process|farnesyl diphosphate metabolic process|squalene synthase activity|sterol biosynthetic process|cholesterol metabolic process|farnesyl-diphosphate farnesyltransferase activity|cholesterol biosynthetic process K00801 farnesyl-diphosphate farnesyltransferase[2.5.1.21] hsa01100|hsa00100 Metabolic pathways - Homo sapiens (human)|Steroid biosynthesis - Homo sapiens (human) 8:11795573-11839309 842 1089 1254 2280 2600 2862 3.53411517013046 4.1540950120501 4.74548199162837 8.5743470574656 8.9538502158169 11.2581521350896 4.14456405793631 9.5954498027907 -1.21113007557043 1.52701420934865e-08 2.72489433388491e-07 DOWN ENSG00000090565 RAB11FIP3 RAB11 family interacting protein 3 (class II) [Source:HGNC Symbol;Acc:HGNC:17224] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0030496|GO:0048523|GO:0050794|GO:0043229|GO:0043167|GO:0009986|GO:0051051|GO:0051641|GO:0045171|GO:0023051|GO:0016043|GO:0043227|GO:0023057|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0042802|GO:0060341|GO:0007049|GO:0070164|GO:0006810|GO:0022402|GO:0032940|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0007267|GO:0032880|GO:0046983|GO:0045184|GO:0046883|GO:0010646|GO:0008104|GO:0007154|GO:0051649|GO:0046888|GO:0010008|GO:0051048|GO:1903531|GO:0051301|GO:0010817|GO:0051224|GO:0032154|GO:0005768|GO:0006996|GO:0016192|GO:0005829|GO:0005813|GO:0046872|GO:0005815|GO:0050709|GO:0051223|GO:0015031|GO:0070201|GO:0046907|GO:0055037|GO:0051046|GO:0031981|GO:0009914|GO:0009306|GO:0005654|GO:0034613|GO:0046903|GO:0051020|GO:0005856|GO:0000910|GO:0005634|GO:0042803|GO:0055038|GO:0033365|GO:0032456|GO:0050708|GO:0005509|GO:0015630|GO:0016197|GO:0031267|GO:0046879|GO:0017016|GO:0061512|GO:0030306|GO:0017137 signaling|cell|membrane|cellular process|extracellular region|binding|midbody|negative regulation of cellular process|regulation of cellular process|intracellular organelle|ion binding|cell surface|negative regulation of transport|cellular localization|intercellular bridge|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of signaling|intracellular|protein binding|endomembrane system|organelle membrane|identical protein binding|regulation of cellular localization|cell cycle|negative regulation of adiponectin secretion|transport|cell cycle process|secretion by cell|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|cell-cell signaling|regulation of protein localization|protein dimerization activity|establishment of protein localization|regulation of hormone secretion|regulation of cell communication|protein localization|cell communication|establishment of localization in cell|negative regulation of hormone secretion|endosome membrane|negative regulation of secretion|negative regulation of secretion by cell|cell division|regulation of hormone levels|negative regulation of protein transport|cleavage furrow|endosome|organelle organization|vesicle-mediated transport|cytosol|centrosome|metal ion binding|microtubule organizing center|negative regulation of protein secretion|regulation of protein transport|protein transport|regulation of establishment of protein localization|intracellular transport|recycling endosome|regulation of secretion|nuclear lumen|hormone transport|protein secretion|nucleoplasm|cellular protein localization|secretion|GTPase binding|cytoskeleton|cytokinesis|nucleus|protein homodimerization activity|recycling endosome membrane|protein localization to organelle|endocytic recycling|regulation of protein secretion|calcium ion binding|microtubule cytoskeleton|endosomal transport|small GTPase binding|hormone secretion|Ras GTPase binding|protein localization to cilium|ADP-ribosylation factor binding|Rab GTPase binding K12485 Rab11 family-interacting protein 3/4[-] hsa04144 Endocytosis - Homo sapiens (human) 16:425619-523011 176 214 268 496 660 598 1.08750029939004 1.20173677890644 1.49301630823227 2.74596548597006 3.34601376845096 3.46295269262351 1.26075112884292 3.18497731568151 -1.33699958018541 1.52927368567993e-08 2.72729609392405e-07 DOWN ENSG00000165782 TMEM55B transmembrane protein 55B [Source:HGNC Symbol;Acc:HGNC:19299] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0044255|GO:0016788|GO:0019637|GO:0043231|GO:0005774|GO:0005737|GO:0006629|GO:0010008|GO:0016021|GO:0005768|GO:0046486|GO:0005773|GO:0005770|GO:0006796|GO:0030258|GO:0031902|GO:0042578|GO:0006644|GO:0016311|GO:0046839|GO:0000323|GO:0016791|GO:0005765|GO:0006650|GO:0046488|GO:0005764|GO:0046856|GO:0052866|GO:0034593|GO:0034597 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|cellular lipid metabolic process|hydrolase activity, acting on ester bonds|organophosphate metabolic process|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|lipid metabolic process|endosome membrane|integral component of membrane|endosome|glycerolipid metabolic process|vacuole|late endosome|phosphate-containing compound metabolic process|lipid modification|late endosome membrane|phosphoric ester hydrolase activity|phospholipid metabolic process|dephosphorylation|phospholipid dephosphorylation|lytic vacuole|phosphatase activity|lysosomal membrane|glycerophospholipid metabolic process|phosphatidylinositol metabolic process|lysosome|phosphatidylinositol dephosphorylation|phosphatidylinositol phosphate phosphatase activity|phosphatidylinositol bisphosphate phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity K13084 phosphatidylinositol-4,5-bisphosphate 4-phosphatase[3.1.3.78] hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) 14:20457719-20461612 783 734 1029 412 442 426 6.39202894806068 5.44569423835577 7.57367725581049 3.01350416838399 2.96051303111801 3.25923293345967 6.47046681407565 3.07775004432056 1.0719937299847 1.55220138411311e-08 2.76653254455599e-07 UP ENSG00000198886 MT-ND4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 [Source:HGNC Symbol;Acc:HGNC:7459] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0070469|GO:0043227|GO:0031224|GO:0005622|GO:0043234|GO:0048856|GO:0031090|GO:0006725|GO:0019866|GO:1901360|GO:0005746|GO:0007275|GO:0048513|GO:0034641|GO:0015980|GO:0044281|GO:0030902|GO:0019637|GO:0046483|GO:0007420|GO:0043231|GO:0010243|GO:0005737|GO:0060322|GO:0031966|GO:0006139|GO:0016651|GO:0055086|GO:0045271|GO:0022037|GO:0001666|GO:0021549|GO:0006091|GO:0016021|GO:0022900|GO:0010033|GO:0055114|GO:0007568|GO:0005740|GO:0007417|GO:0019693|GO:0005747|GO:0009790|GO:0009116|GO:0022904|GO:0005743|GO:0043279|GO:0005739|GO:0016655|GO:0014070|GO:0006796|GO:0007399|GO:0006119|GO:0045333|GO:0003954|GO:0097305|GO:0009792|GO:0009259|GO:0009117|GO:0042773|GO:0016310|GO:0045471|GO:0006163|GO:0035094|GO:0006120|GO:0042278|GO:0042775|GO:0043009|GO:0008137|GO:0046034|GO:0001701 developmental process|macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|respiratory chain|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein complex|anatomical structure development|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|organic cyclic compound metabolic process|mitochondrial respiratory chain|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|hindbrain development|organophosphate metabolic process|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|head development|mitochondrial membrane|nucleobase-containing compound metabolic process|oxidoreductase activity, acting on NAD(P)H|nucleobase-containing small molecule metabolic process|respiratory chain complex I|metencephalon development|response to hypoxia|cerebellum development|generation of precursor metabolites and energy|integral component of membrane|electron transport chain|response to organic substance|oxidation-reduction process|aging|mitochondrial envelope|central nervous system development|ribose phosphate metabolic process|mitochondrial respiratory chain complex I|embryo development|nucleoside metabolic process|respiratory electron transport chain|mitochondrial inner membrane|response to alkaloid|mitochondrion|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|response to organic cyclic compound|phosphate-containing compound metabolic process|nervous system development|oxidative phosphorylation|cellular respiration|NADH dehydrogenase activity|response to alcohol|embryo development ending in birth or egg hatching|ribonucleotide metabolic process|nucleotide metabolic process|ATP synthesis coupled electron transport|phosphorylation|response to ethanol|purine nucleotide metabolic process|response to nicotine|mitochondrial electron transport, NADH to ubiquinone|purine nucleoside metabolic process|mitochondrial ATP synthesis coupled electron transport|chordate embryonic development|NADH dehydrogenase (ubiquinone) activity|ATP metabolic process|in utero embryonic development K03881 NADH-ubiquinone oxidoreductase chain 4[1.6.5.3] hsa01100|hsa05012|hsa00190 Metabolic pathways - Homo sapiens (human)|Parkinson,s disease - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human) MT:10760-12137 176 0 202 0 0 0 9.03461787185568 0 9.34893524061498 0 0 0 6.12785103749022 0 Inf 1.55574753865415e-08 2.77119850948574e-07 UP ENSG00000109762 SNX25 sorting nexin 25 [Source:HGNC Symbol;Acc:HGNC:21883] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0008289|GO:0023057|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0006810|GO:0005102|GO:0043168|GO:0005543|GO:0090287|GO:0043231|GO:0005737|GO:0071559|GO:0009966|GO:0045184|GO:0010646|GO:0090288|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0010008|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0005768|GO:0032268|GO:0005126|GO:0032801|GO:0090101|GO:0007166|GO:0043412|GO:0035091|GO:0015031|GO:0036211|GO:0032269|GO:0071560|GO:0070848|GO:0006796|GO:0044267|GO:0051174|GO:0071310|GO:0051246|GO:0043112|GO:0060393|GO:0071363|GO:0016310|GO:0007179|GO:0030512|GO:0007167|GO:0060394|GO:0005160|GO:0006464|GO:0017015|GO:0006468|GO:0034713|GO:0042325|GO:0001932|GO:0042326|GO:0007178|GO:0001933|GO:0060389 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|lipid binding|negative regulation of signaling|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|transport|receptor binding|anion binding|phospholipid binding|regulation of cellular response to growth factor stimulus|intracellular membrane-bounded organelle|cytoplasm|response to transforming growth factor beta|regulation of signal transduction|establishment of protein localization|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|protein localization|cell communication|signal transduction|negative regulation of signal transduction|endosome membrane|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endosome|regulation of cellular protein metabolic process|cytokine receptor binding|receptor catabolic process|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|macromolecule modification|phosphatidylinositol binding|protein transport|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|response to growth factor|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of protein metabolic process|receptor metabolic process|regulation of pathway-restricted SMAD protein phosphorylation|cellular response to growth factor stimulus|phosphorylation|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|negative regulation of pathway-restricted SMAD protein phosphorylation|transforming growth factor beta receptor binding|cellular protein modification process|regulation of transforming growth factor beta receptor signaling pathway|protein phosphorylation|type I transforming growth factor beta receptor binding|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|pathway-restricted SMAD protein phosphorylation - - - - 4:185204237-185370185 177 187 261 537 566 543 1.93694366644351 1.85980134799565 2.57512959573684 5.26522211961006 5.08193149808227 5.56894690781662 2.123958203392 5.30536684183632 -1.32069713420275 1.55713737514439e-08 2.77202022644965e-07 DOWN ENSG00000132964 CDK8 cyclin-dependent kinase 8 [Source:HGNC Symbol;Acc:HGNC:1779] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0043231|GO:0016592|GO:0071559|GO:0006139|GO:0007154|GO:0007165|GO:0000166|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0010468|GO:0034645|GO:0007166|GO:0035639|GO:0043412|GO:0051252|GO:0001883|GO:0010628|GO:0036211|GO:0071560|GO:0032549|GO:0031981|GO:0070848|GO:0005654|GO:0016301|GO:0006796|GO:0044267|GO:0010467|GO:0071310|GO:0017076|GO:0031328|GO:0009059|GO:0016070|GO:0016773|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:0005524|GO:2001141|GO:0071363|GO:0030554|GO:0016310|GO:0007179|GO:0007167|GO:0004672|GO:0007219|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006352|GO:0006357|GO:0006468|GO:1903506|GO:0004674|GO:0097472|GO:0007178|GO:0006367|GO:0004693|GO:0008353 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|mediator complex|response to transforming growth factor beta|nucleobase-containing compound metabolic process|cell communication|signal transduction|nucleotide binding|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of gene expression|protein modification process|cellular response to transforming growth factor beta stimulus|ribonucleoside binding|nuclear lumen|response to growth factor|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|cellular response to organic substance|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|protein kinase activity|Notch signaling pathway|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|protein serine/threonine kinase activity|cyclin-dependent protein kinase activity|transmembrane receptor protein serine/threonine kinase signaling pathway|transcription initiation from RNA polymerase II promoter|cyclin-dependent protein serine/threonine kinase activity|RNA polymerase II carboxy-terminal domain kinase activity - - - - 13:26254104-26405238 117 181 343 713 733 705 1.30848874310739 1.83968886971849 3.45854616187604 7.14451243172966 6.72600465977351 7.38929697732405 2.20224125823397 7.08660468960907 -1.68612204719216 1.5656356357863e-08 2.78548785880598e-07 DOWN ENSG00000164305 CASP3 caspase 3 [Source:HGNC Symbol;Acc:HGNC:1504] GO:0032502|GO:0032991|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0001776|GO:0009653|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0002262|GO:0009607|GO:0009605|GO:0009893|GO:0016787|GO:0030234|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0051726|GO:0042127|GO:0007049|GO:0016337|GO:0004857|GO:0006725|GO:0070661|GO:0009888|GO:0048468|GO:0009314|GO:0021766|GO:1901360|GO:0010941|GO:0098797|GO:0007275|GO:0048513|GO:0050877|GO:0070489|GO:0034101|GO:0005102|GO:0034641|GO:0097194|GO:0008047|GO:0043062|GO:0030155|GO:0030900|GO:0031325|GO:0046483|GO:0033554|GO:0007420|GO:0010942|GO:0098609|GO:0045786|GO:0043231|GO:0008233|GO:0019899|GO:0010243|GO:0005737|GO:0009611|GO:0060322|GO:0032403|GO:0042592|GO:0001775|GO:0006979|GO:0060548|GO:0042493|GO:0006139|GO:0043085|GO:0009617|GO:0007162|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0007165|GO:0002260|GO:0030220|GO:0009725|GO:0008219|GO:0007611|GO:0002695|GO:0008285|GO:0001666|GO:0021543|GO:0050790|GO:0019207|GO:0043086|GO:0048869|GO:0010035|GO:0021537|GO:0019538|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0009636|GO:0051249|GO:0032268|GO:0000902|GO:0005829|GO:0009743|GO:0042113|GO:0019210|GO:0005126|GO:0032943|GO:0030218|GO:0007166|GO:0033993|GO:0043412|GO:0022617|GO:0030097|GO:0072358|GO:0034097|GO:0007417|GO:0051345|GO:0042542|GO:0060229|GO:0002237|GO:0019887|GO:0045736|GO:0043069|GO:0034109|GO:1901216|GO:0070997|GO:0051604|GO:0044265|GO:0021761|GO:0000904|GO:0010038|GO:0043200|GO:0036211|GO:0032269|GO:0042060|GO:0048872|GO:0001782|GO:0051250|GO:0002020|GO:0022408|GO:0007600|GO:0022407|GO:0043029|GO:0043279|GO:0031981|GO:0007159|GO:0051247|GO:0070848|GO:0006508|GO:0005654|GO:0070664|GO:0006259|GO:0043588|GO:1901214|GO:0046677|GO:0032270|GO:0042110|GO:0012501|GO:0014070|GO:0060429|GO:0000302|GO:0006796|GO:0010212|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0007399|GO:0071310|GO:0050890|GO:0030198|GO:0019439|GO:0051246|GO:0006921|GO:0046651|GO:0030154|GO:0045121|GO:0043068|GO:0072359|GO:0031264|GO:0032496|GO:0005634|GO:0009416|GO:0043067|GO:0048545|GO:0097305|GO:0006974|GO:0045165|GO:0097190|GO:0032025|GO:0030182|GO:1903038|GO:0042098|GO:0097193|GO:0050863|GO:0030262|GO:0043065|GO:0009411|GO:0050954|GO:0030855|GO:0050869|GO:0016485|GO:0032813|GO:0043523|GO:0050868|GO:0030162|GO:0030216|GO:0097192|GO:0034284|GO:0045862|GO:0043525|GO:0071363|GO:0016310|GO:0043627|GO:0038179|GO:0052547|GO:0008544|GO:0036344|GO:0071407|GO:0070486|GO:1904030|GO:0007167|GO:0070001|GO:0004175|GO:0035329|GO:0050864|GO:0004860|GO:0032355|GO:0035094|GO:0042981|GO:0006308|GO:0043066|GO:0016538|GO:0033673|GO:0051402|GO:0090305|GO:0034612|GO:0042100|GO:0034111|GO:0032945|GO:0030099|GO:0010165|GO:0022008|GO:0008234|GO:0006464|GO:0016004|GO:0010952|GO:0097191|GO:0031960|GO:0000079|GO:0050672|GO:0043549|GO:0006915|GO:0048011|GO:0030291|GO:0051384|GO:0016005|GO:0045859|GO:0010950|GO:0007605|GO:0006469|GO:0043281|GO:0006468|GO:0048699|GO:0042325|GO:0001932|GO:0004197|GO:0042326|GO:0004190|GO:0031638|GO:0004861|GO:0030889|GO:0030888|GO:0043280|GO:0050798|GO:0000737|GO:0006919|GO:0042130|GO:0042129|GO:0001933|GO:0034349|GO:0071593|GO:0007169|GO:0052548|GO:0009913|GO:0005123|GO:0006309|GO:0097153|GO:0046006|GO:2001056|GO:0071901|GO:0009749|GO:0008635|GO:0071900|GO:2000116|GO:0097202|GO:0046007|GO:0097200 developmental process|macromolecular complex|immune system process|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|leukocyte homeostasis|anatomical structure morphogenesis|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|hydrolase activity|enzyme regulator activity|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|regulation of cell cycle|regulation of cell proliferation|cell cycle|single organismal cell-cell adhesion|enzyme inhibitor activity|cellular aromatic compound metabolic process|leukocyte proliferation|tissue development|cell development|response to radiation|hippocampus development|organic cyclic compound metabolic process|regulation of cell death|plasma membrane protein complex|multicellular organism development|animal organ development|neurological system process|T cell aggregation|erythrocyte homeostasis|receptor binding|cellular nitrogen compound metabolic process|execution phase of apoptosis|enzyme activator activity|extracellular structure organization|regulation of cell adhesion|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|brain development|positive regulation of cell death|cell-cell adhesion|negative regulation of cell cycle|intracellular membrane-bounded organelle|peptidase activity|enzyme binding|response to organonitrogen compound|cytoplasm|response to wounding|head development|protein complex binding|homeostatic process|cell activation|response to oxidative stress|negative regulation of cell death|response to drug|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|negative regulation of cell adhesion|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|signal transduction|lymphocyte homeostasis|platelet formation|response to hormone|cell death|learning or memory|negative regulation of leukocyte activation|negative regulation of cell proliferation|response to hypoxia|pallium development|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|response to inorganic substance|telencephalon development|protein metabolic process|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to toxic substance|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|response to carbohydrate|B cell activation|kinase inhibitor activity|cytokine receptor binding|mononuclear cell proliferation|erythrocyte differentiation|cell surface receptor signaling pathway|response to lipid|macromolecule modification|extracellular matrix disassembly|hemopoiesis|cardiovascular system development|response to cytokine|central nervous system development|positive regulation of hydrolase activity|response to hydrogen peroxide|lipase activator activity|response to molecule of bacterial origin|protein kinase regulator activity|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of programmed cell death|homotypic cell-cell adhesion|positive regulation of neuron death|neuron death|protein maturation|cellular macromolecule catabolic process|limbic system development|cell morphogenesis involved in differentiation|response to metal ion|response to amino acid|protein modification process|negative regulation of cellular protein metabolic process|wound healing|homeostasis of number of cells|B cell homeostasis|negative regulation of lymphocyte activation|protease binding|negative regulation of cell-cell adhesion|sensory perception|regulation of cell-cell adhesion|T cell homeostasis|response to alkaloid|nuclear lumen|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|response to growth factor|proteolysis|nucleoplasm|negative regulation of leukocyte proliferation|DNA metabolic process|skin development|regulation of neuron death|response to antibiotic|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|response to organic cyclic compound|epithelium development|response to reactive oxygen species|phosphate-containing compound metabolic process|response to ionizing radiation|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|nervous system development|cellular response to organic substance|cognition|extracellular matrix organization|aromatic compound catabolic process|regulation of protein metabolic process|cellular component disassembly involved in execution phase of apoptosis|lymphocyte proliferation|cell differentiation|membrane raft|positive regulation of programmed cell death|circulatory system development|death-inducing signaling complex|response to lipopolysaccharide|nucleus|response to light stimulus|regulation of programmed cell death|response to steroid hormone|response to alcohol|cellular response to DNA damage stimulus|cell fate commitment|apoptotic signaling pathway|response to cobalt ion|neuron differentiation|negative regulation of leukocyte cell-cell adhesion|T cell proliferation|intrinsic apoptotic signaling pathway|regulation of T cell activation|apoptotic nuclear changes|positive regulation of apoptotic process|response to UV|sensory perception of mechanical stimulus|epithelial cell differentiation|negative regulation of B cell activation|protein processing|tumor necrosis factor receptor superfamily binding|regulation of neuron apoptotic process|negative regulation of T cell activation|regulation of proteolysis|keratinocyte differentiation|extrinsic apoptotic signaling pathway in absence of ligand|response to monosaccharide|positive regulation of proteolysis|positive regulation of neuron apoptotic process|cellular response to growth factor stimulus|phosphorylation|response to estrogen|neurotrophin signaling pathway|regulation of peptidase activity|epidermis development|platelet morphogenesis|cellular response to organic cyclic compound|leukocyte aggregation|negative regulation of cyclin-dependent protein kinase activity|enzyme linked receptor protein signaling pathway|aspartic-type peptidase activity|endopeptidase activity|hippo signaling|regulation of B cell activation|protein kinase inhibitor activity|response to estradiol|response to nicotine|regulation of apoptotic process|DNA catabolic process|negative regulation of apoptotic process|cyclin-dependent protein serine/threonine kinase regulator activity|negative regulation of kinase activity|neuron apoptotic process|nucleic acid phosphodiester bond hydrolysis|response to tumor necrosis factor|B cell proliferation|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|myeloid cell differentiation|response to X-ray|neurogenesis|cysteine-type peptidase activity|cellular protein modification process|phospholipase activator activity|positive regulation of peptidase activity|extrinsic apoptotic signaling pathway|response to corticosteroid|regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of lymphocyte proliferation|regulation of kinase activity|apoptotic process|neurotrophin TRK receptor signaling pathway|protein serine/threonine kinase inhibitor activity|response to glucocorticoid|phospholipase A2 activator activity|regulation of protein kinase activity|positive regulation of endopeptidase activity|sensory perception of sound|negative regulation of protein kinase activity|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|generation of neurons|regulation of phosphorylation|regulation of protein phosphorylation|cysteine-type endopeptidase activity|negative regulation of phosphorylation|aspartic-type endopeptidase activity|zymogen activation|cyclin-dependent protein serine/threonine kinase inhibitor activity|negative regulation of B cell proliferation|regulation of B cell proliferation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activated T cell proliferation|DNA catabolic process, endonucleolytic|activation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of T cell proliferation|regulation of T cell proliferation|negative regulation of protein phosphorylation|glial cell apoptotic process|lymphocyte aggregation|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|epidermal cell differentiation|death receptor binding|apoptotic DNA fragmentation|cysteine-type endopeptidase activity involved in apoptotic process|regulation of activated T cell proliferation|positive regulation of cysteine-type endopeptidase activity|negative regulation of protein serine/threonine kinase activity|response to glucose|activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c|regulation of protein serine/threonine kinase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|negative regulation of activated T cell proliferation|cysteine-type endopeptidase activity involved in execution phase of apoptosis K02187 caspase 3[3.4.22.56] hsa05200|hsa05206|hsa04010|hsa05203|hsa05205|hsa05016|hsa05168|hsa05152|hsa05010|hsa04932|hsa05161|hsa05012|hsa04210|hsa04650|hsa05145|hsa04726|hsa04668|hsa04933|hsa05146|hsa05133|hsa04115|hsa05120|hsa05210|hsa05416|hsa05134|hsa05014 Pathways in cancer - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Parkinson,s disease - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Pertussis - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Viral myocarditis - Homo sapiens (human)|Legionellosis - Homo sapiens (human)|Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) 4:184627696-184649509 1832 1950 1549 913 899 653 22.5805745020715 21.8436002094673 17.2137363183987 10.0827257056234 9.09152997298253 7.54312973016743 20.5459703433125 8.90579513625779 1.20603913723553 1.58286967392906e-08 2.81447237912318e-07 UP ENSG00000224635 RP4-564F22.5 - - - - - - - 20:38406011-38416797 47 40 32 6 10 8 1.65900354837126 1.28317968221696 1.01837870036981 0.18976303175699 0.289620653916064 0.264648942002069 1.32018731031934 0.248010875891708 2.41226734315532 1.59744524380529e-08 2.83869823265258e-07 UP ENSG00000085433 WDR47 WD repeat domain 47 [Source:HGNC Symbol;Acc:HGNC:29141] GO:0032502|GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0048856|GO:0007275|GO:0005874|GO:0005737|GO:0005856|GO:0015630 developmental process|cell|binding|intracellular organelle|intracellular|protein binding|anatomical structure development|multicellular organism development|microtubule|cytoplasm|cytoskeleton|microtubule cytoskeleton - - - - 1:108970214-109042113 809 914 1201 452 493 531 7.56359185745386 7.76614524842523 10.1236414712685 3.7863049967101 3.78175936449418 4.65267953355057 8.48445952571586 4.07358129825162 1.05852505962759 1.60087040633453e-08 2.84309251104765e-07 UP ENSG00000131845 ZNF304 zinc finger protein 304 [Source:HGNC Symbol;Acc:HGNC:13505] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 19:57351307-57359898 790 1059 887 428 460 478 7.29721845208376 8.89009456460018 7.38699794765288 3.54219212075694 3.48623356773483 4.13796490318252 7.85810365477894 3.72213019722476 1.07805267761095 1.63493322385145e-08 2.90186066973015e-07 UP ENSG00000184465 WDR27 WD repeat domain 27 [Source:HGNC Symbol;Acc:HGNC:21248] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|nuclear lumen|nucleoplasm|nucleus - - - - 6:169457212-169702048 58 62 131 290 272 420 0.329194049092535 0.319811660828236 0.670359559683173 1.47474974515459 1.26666113336425 2.23409603595938 0.439788423201315 1.65850230482607 -1.91499948411517 1.63605782740617e-08 2.90213133567343e-07 DOWN ENSG00000182308 DCAF4L1 DDB1 and CUL4 associated factor 4-like 1 [Source:HGNC Symbol;Acc:HGNC:27723] GO:0005488|GO:0005515 binding|protein binding - - - - 4:41981696-41986467 91 104 76 27 28 29 1.34892129139838 1.40106442083471 1.01571635688239 0.358602464643444 0.340543360472479 0.402870529380769 1.25523402303849 0.367338784832231 1.77277322841347 1.63909935158585e-08 2.90580000250855e-07 UP ENSG00000260822 GS1-358P8.4 - - - - - - - X:24545516-24550466 76 80 127 246 318 429 1.08584444109395 1.03877684635943 1.63594808813261 3.14909650486467 3.72776080529594 5.74433066477713 1.25352312519533 4.20706265831258 -1.74682469370453 1.65083203690698e-08 2.92486288604279e-07 DOWN ENSG00000001497 LAS1L LAS1-like, ribosome biogenesis factor [Source:HGNC Symbol;Acc:HGNC:25726] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0043234|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0022613|GO:0005730|GO:0003723|GO:0005815|GO:0042254|GO:0031981|GO:1990234|GO:0005654|GO:0010467|GO:0035097|GO:0016070|GO:0005856|GO:0005634|GO:0006364|GO:0006396|GO:0034660|GO:0015630|GO:0044822|GO:0016072|GO:0071339 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|microtubule organizing center|ribosome biogenesis|nuclear lumen|transferase complex|nucleoplasm|gene expression|histone methyltransferase complex|RNA metabolic process|cytoskeleton|nucleus|rRNA processing|RNA processing|ncRNA metabolic process|microtubule cytoskeleton|poly(A) RNA binding|rRNA metabolic process|MLL1 complex - - - - X:65512582-65534775 3044 3236 3404 9202 9970 6215 31.74918475634 30.6744253797009 32.0104515091564 85.9939429957232 85.3200405981908 60.7516465374982 31.4780205483991 77.3552100438041 -1.29715364181195 1.65496162775234e-08 2.93044035794297e-07 DOWN ENSG00000106723 SPIN1 spindlin 1 [Source:HGNC Symbol;Acc:HGNC:11243] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0019953|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0007049|GO:0006725|GO:0042393|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0043231|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007276|GO:0007165|GO:0009967|GO:0044249|GO:0006996|GO:0051276|GO:0005730|GO:0030111|GO:0034645|GO:0007166|GO:0006325|GO:0031981|GO:0010467|GO:0035064|GO:0030177|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0005819|GO:0016055|GO:0032774|GO:0034660|GO:0015630|GO:0016568|GO:0006351|GO:0009303 developmental process|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|sexual reproduction|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|cell cycle|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|gamete generation|signal transduction|positive regulation of signal transduction|cellular biosynthetic process|organelle organization|chromosome organization|nucleolus|regulation of Wnt signaling pathway|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|chromatin organization|nuclear lumen|gene expression|methylated histone binding|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|spindle|Wnt signaling pathway|RNA biosynthetic process|ncRNA metabolic process|microtubule cytoskeleton|chromatin modification|transcription, DNA-templated|rRNA transcription - - - - 9:88388419-88478694 475 507 798 1199 2084 1715 4.94481229325644 4.79671708296484 7.48985291041981 11.1833862555142 17.8000758194407 16.7320526425854 5.74379409554703 15.2385049058468 -1.40764542551997 1.69820424372906e-08 3.00522759290381e-07 DOWN ENSG00000151883 PARP8 poly(ADP-ribose) polymerase family member 8 [Source:HGNC Symbol;Acc:HGNC:26124] GO:0005623|GO:0008152|GO:0003824|GO:0005622|GO:0016740|GO:0016757|GO:0016763|GO:0003950 cell|metabolic process|catalytic activity|intracellular|transferase activity|transferase activity, transferring glycosyl groups|transferase activity, transferring pentosyl groups|NAD+ ADP-ribosyltransferase activity - - - - 5:50665899-50846522 17 18 21 70 71 102 0.0738865561040402 0.0711011635897543 0.0822922100002528 0.272597938313631 0.253191237890758 0.415483393519635 0.0757599765646824 0.313757523241341 -2.05014226261084 1.7032782579571e-08 3.01242115598644e-07 DOWN ENSG00000169684 CHRNA5 cholinergic receptor, nicotinic alpha 5 [Source:HGNC Symbol;Acc:HGNC:1959] GO:0032991|GO:0004871|GO:0005215|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0022857|GO:0050794|GO:0043167|GO:0042165|GO:0038023|GO:0044297|GO:0044708|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0097060|GO:0030594|GO:0043025|GO:0030534|GO:0006810|GO:0098797|GO:0045211|GO:0005887|GO:0043169|GO:0010243|GO:0004888|GO:0007267|GO:0043235|GO:0043005|GO:0046983|GO:0036477|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0042166|GO:0016021|GO:0010033|GO:0035095|GO:0015464|GO:0046982|GO:0015267|GO:0006811|GO:0015075|GO:0043279|GO:0030425|GO:0034702|GO:0014070|GO:0005892|GO:0034220|GO:0015276|GO:0098655|GO:0005216|GO:0006812|GO:0035094|GO:0008324|GO:0005230|GO:0005261|GO:0007268|GO:0005231|GO:0007271|GO:0007274|GO:0004889 macromolecular complex|signal transducer activity|transporter activity|synapse|behavior|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|transmembrane transporter activity|regulation of cellular process|ion binding|neurotransmitter binding|signaling receptor activity|cell body|single-organism behavior|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|protein complex|synaptic membrane|neurotransmitter receptor activity|neuronal cell body|adult behavior|transport|plasma membrane protein complex|postsynaptic membrane|integral component of plasma membrane|cation binding|response to organonitrogen compound|transmembrane signaling receptor activity|cell-cell signaling|receptor complex|neuron projection|protein dimerization activity|somatodendritic compartment|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|acetylcholine binding|integral component of membrane|response to organic substance|behavioral response to nicotine|acetylcholine receptor activity|protein heterodimerization activity|channel activity|ion transport|ion transmembrane transporter activity|response to alkaloid|dendrite|ion channel complex|response to organic cyclic compound|acetylcholine-gated channel complex|ion transmembrane transport|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|cation transport|response to nicotine|cation transmembrane transporter activity|extracellular ligand-gated ion channel activity|cation channel activity|synaptic transmission|excitatory extracellular ligand-gated ion channel activity|synaptic transmission, cholinergic|neuromuscular synaptic transmission|acetylcholine-activated cation-selective channel activity K04807 nicotinic acetylcholine receptor alpha-5[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 15:78565520-78595269 32 40 47 112 156 147 0.399084368166269 0.453366023124608 0.5284676165929 1.25148078616314 1.59625694160445 1.71812471002845 0.460306002627926 1.52195414593201 -1.72525973209426 1.71815282136555e-08 3.03692920835093e-07 DOWN ENSG00000099860 GADD45B growth arrest and DNA damage inducible beta [Source:HGNC Symbol;Acc:HGNC:4096] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0010941|GO:0007275|GO:0031325|GO:0033554|GO:0010942|GO:0043231|GO:0005737|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0044092|GO:0007165|GO:0008219|GO:0050790|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0043412|GO:0051347|GO:0036211|GO:0032269|GO:0031098|GO:0051247|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:0030154|GO:0043068|GO:1902531|GO:0005634|GO:0043067|GO:0070304|GO:0031401|GO:0043065|GO:0043408|GO:0016310|GO:0043410|GO:0032872|GO:0042981|GO:0033673|GO:0006464|GO:0051403|GO:0043549|GO:0006915|GO:0033674|GO:0000186|GO:0045859|GO:0045860|GO:1900744|GO:0006469|GO:0046328|GO:0038066|GO:0006468|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0042326|GO:0000185|GO:0032874|GO:0001934|GO:0001933|GO:0042327|GO:0046330|GO:1900745|GO:0071902|GO:0071900|GO:0032147 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|regulation of cell death|multicellular organism development|positive regulation of cellular metabolic process|cellular response to stress|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|negative regulation of molecular function|signal transduction|cell death|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|macromolecule modification|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|stress-activated protein kinase signaling cascade|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|cell differentiation|positive regulation of programmed cell death|regulation of intracellular signal transduction|nucleus|regulation of programmed cell death|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of protein modification process|positive regulation of apoptotic process|regulation of MAPK cascade|phosphorylation|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|negative regulation of kinase activity|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|activation of MAPKK activity|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of p38MAPK cascade|negative regulation of protein kinase activity|regulation of JNK cascade|p38MAPK cascade|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|activation of MAPKKK activity|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of JNK cascade|positive regulation of p38MAPK cascade|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity K04402 growth arrest and DNA-damage-inducible protein[-] hsa04010|hsa04210|hsa04068|hsa04110|hsa04064|hsa04115 MAPK signaling pathway - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 19:2476122-2478259 312 275 370 124 159 125 4.19579193042984 3.36103393467718 4.48617462045634 1.49410061794664 1.75438076289651 1.57543268507049 4.01433349518779 1.60797135530455 1.31991876885009 1.72066263411599e-08 3.03956581531945e-07 UP ENSG00000150471 ADGRL3 adhesion G protein-coupled receptor L3 [Source:HGNC Symbol;Acc:HGNC:20974] GO:0040011|GO:0032502|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0031987|GO:0050794|GO:0044089|GO:0043167|GO:0038023|GO:0048870|GO:0005911|GO:0016043|GO:0030246|GO:0007155|GO:0071944|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0007626|GO:0048856|GO:0051130|GO:0007275|GO:0051128|GO:0022607|GO:0098609|GO:0050803|GO:0005887|GO:0043169|GO:0010243|GO:0004888|GO:0006928|GO:0051963|GO:0043005|GO:0031226|GO:0007154|GO:0016477|GO:0007165|GO:0051965|GO:0050808|GO:0048869|GO:0016021|GO:0010033|GO:0007186|GO:0007416|GO:0046872|GO:0007166|GO:0030424|GO:0050807|GO:0001764|GO:0043279|GO:0014070|GO:0060359|GO:0007399|GO:0030154|GO:0004930|GO:0042220|GO:0051960|GO:0005509|GO:0022008|GO:0048699 locomotion|developmental process|signal transducer activity|behavior|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|locomotion involved in locomotory behavior|regulation of cellular process|positive regulation of cellular component biogenesis|ion binding|signaling receptor activity|cell motility|cell-cell junction|cellular component organization|carbohydrate binding|cell adhesion|cell periphery|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|locomotory behavior|anatomical structure development|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component organization|cellular component assembly|cell-cell adhesion|regulation of synapse structure or activity|integral component of plasma membrane|cation binding|response to organonitrogen compound|transmembrane signaling receptor activity|movement of cell or subcellular component|regulation of synapse assembly|neuron projection|intrinsic component of plasma membrane|cell communication|cell migration|signal transduction|positive regulation of synapse assembly|synapse organization|cellular developmental process|integral component of membrane|response to organic substance|G-protein coupled receptor signaling pathway|synapse assembly|metal ion binding|cell surface receptor signaling pathway|axon|regulation of synapse organization|neuron migration|response to alkaloid|response to organic cyclic compound|response to ammonium ion|nervous system development|cell differentiation|G-protein coupled receptor activity|response to cocaine|regulation of nervous system development|calcium ion binding|neurogenesis|generation of neurons - - - - 4:61201258-62078335 4 2 7 32 28 45 0.0114981205263811 0.00522512310148084 0.0181417072296552 0.0824205780959347 0.06604108246331 0.121234247399087 0.011621650285839 0.0898986359861106 -2.95148427877215 1.76932444350551e-08 3.12367900274474e-07 DOWN ENSG00000111725 PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9378] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0051726|GO:0007049|GO:0044255|GO:0006725|GO:0022402|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0016772|GO:0046483|GO:0022607|GO:0045786|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0031588|GO:0006139|GO:0007154|GO:0061024|GO:0006629|GO:0007165|GO:0009725|GO:0016236|GO:0050790|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0007166|GO:0043412|GO:0007005|GO:0006631|GO:1901652|GO:0007050|GO:0071417|GO:0010628|GO:0036211|GO:0043434|GO:1990234|GO:0006461|GO:0016301|GO:0019900|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0008610|GO:0071310|GO:0051246|GO:0009059|GO:0016070|GO:0016773|GO:0032870|GO:0005634|GO:0051259|GO:1901653|GO:0032774|GO:0016310|GO:0007167|GO:0006633|GO:0071375|GO:0004672|GO:0019752|GO:0032868|GO:0019901|GO:0006464|GO:0043549|GO:0006351|GO:0006366|GO:0045859|GO:0006352|GO:1902911|GO:0006468|GO:0051291|GO:0042325|GO:0001932|GO:0032869|GO:0004674|GO:0032787|GO:0007169|GO:0006367|GO:0004679|GO:0008286 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular lipid metabolic process|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular component assembly|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|nucleotide-activated protein kinase complex|nucleobase-containing compound metabolic process|cell communication|membrane organization|lipid metabolic process|signal transduction|response to hormone|macroautophagy|regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|macromolecule modification|mitochondrion organization|fatty acid metabolic process|response to peptide|cell cycle arrest|cellular response to organonitrogen compound|positive regulation of gene expression|protein modification process|response to peptide hormone|transferase complex|protein complex assembly|kinase activity|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|lipid biosynthetic process|cellular response to organic substance|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|nucleus|protein oligomerization|cellular response to peptide|RNA biosynthetic process|phosphorylation|enzyme linked receptor protein signaling pathway|fatty acid biosynthetic process|cellular response to peptide hormone stimulus|protein kinase activity|carboxylic acid metabolic process|response to insulin|protein kinase binding|cellular protein modification process|regulation of kinase activity|transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of protein kinase activity|DNA-templated transcription, initiation|protein kinase complex|protein phosphorylation|protein heterooligomerization|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|protein serine/threonine kinase activity|monocarboxylic acid metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|transcription initiation from RNA polymerase II promoter|AMP-activated protein kinase activity|insulin receptor signaling pathway K07199 5'-AMP-activated protein kinase, regulatory beta subunit[-] hsa04921|hsa04932|hsa04910|hsa04068|hsa04152|hsa04931|hsa04922|hsa04211|hsa05410|hsa04920|hsa04213|hsa04710 Oxytocin signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Circadian rhythm - Homo sapiens (human) 12:119667753-119681630 634 627 458 204 249 262 3.49521728614702 3.14146744822963 2.27648769251061 1.00765685482893 1.12629761391691 1.35367869287075 2.97105747562909 1.16254438720553 1.35369071369884 1.77113233957318e-08 3.1240358932189e-07 UP ENSG00000140691 ARMC5 armadillo repeat containing 5 [Source:HGNC Symbol;Acc:HGNC:25781] GO:0005623|GO:0005488|GO:0005622|GO:0005515|GO:0005737 cell|binding|intracellular|protein binding|cytoplasm - - - - 16:31458080-31467166 539 528 244 132 148 105 2.70271116071502 2.40616405664311 1.10310088587763 0.593040056089459 0.608891891695785 0.493432300678048 2.07065870107859 0.565121416154431 1.87345701062305 1.77240502702704e-08 3.1240358932189e-07 UP ENSG00000235823 OLMALINC oligodendrocyte maturation-associated long intergenic non-coding RNA [Source:HGNC Symbol;Acc:HGNC:28060] - - - - - - 10:100373615-100383368 99 119 208 417 444 891 2.7451669565419 2.9989099851302 5.20011802177488 10.3602312587956 10.1015177851063 23.1548425677534 3.64806498781566 14.5388638705518 -1.9947111997747 1.77266590845877e-08 3.1240358932189e-07 DOWN ENSG00000213401 MAGEA12 MAGE family member A12 [Source:HGNC Symbol;Acc:HGNC:6799] - - - - - - X:152733779-152737669 1469 1503 1170 653 736 532 29.5457514613732 27.4734055013167 21.2164871009088 11.7675058887416 12.1456101889313 10.0279951936939 26.0785480211996 11.3137037571223 1.20479224623822 1.7910247679911e-08 3.15452822558149e-07 UP ENSG00000073756 PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [Source:HGNC Symbol;Acc:HGNC:9605] GO:0016209|GO:0040011|GO:0032502|GO:0032991|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0097159|GO:0048523|GO:0008283|GO:0016491|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0042175|GO:0071704|GO:0043167|GO:0009628|GO:0019953|GO:0051051|GO:0044237|GO:0051641|GO:0003006|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0051707|GO:0043227|GO:0044708|GO:0008289|GO:0071944|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0004601|GO:0009058|GO:0050793|GO:0005622|GO:0005789|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0048609|GO:0019222|GO:0042802|GO:0048514|GO:0060341|GO:0001893|GO:0008284|GO:0046697|GO:0051272|GO:1903409|GO:0051726|GO:0042127|GO:0007049|GO:0044255|GO:0098869|GO:0001890|GO:0050804|GO:0045595|GO:0006725|GO:0009888|GO:0009314|GO:0051213|GO:0006810|GO:0009612|GO:1901360|GO:0001568|GO:0010941|GO:0034405|GO:0006082|GO:0009991|GO:0044853|GO:0007275|GO:0010632|GO:0048513|GO:0050877|GO:0034641|GO:0016701|GO:0044281|GO:0006952|GO:2001057|GO:0019637|GO:0031325|GO:0046483|GO:2000147|GO:0033554|GO:0007566|GO:0050806|GO:0010942|GO:0001817|GO:0050803|GO:0045786|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0019899|GO:0010243|GO:0031652|GO:0005737|GO:0003012|GO:0001816|GO:0016705|GO:0007267|GO:0009611|GO:0032880|GO:0035633|GO:0051222|GO:0006928|GO:0042592|GO:0072593|GO:0043005|GO:0030728|GO:0009966|GO:0046983|GO:1903524|GO:0045184|GO:0051186|GO:0060135|GO:0006769|GO:0006979|GO:0048871|GO:0001819|GO:0042493|GO:0032388|GO:0010646|GO:0006139|GO:0009617|GO:0001525|GO:0055086|GO:1900182|GO:0008104|GO:0007154|GO:0007565|GO:0051270|GO:0007276|GO:0006629|GO:0016477|GO:0007165|GO:0005783|GO:0001503|GO:0042180|GO:0051649|GO:0009725|GO:0045932|GO:0008219|GO:0007611|GO:0090316|GO:0010634|GO:0008285|GO:0001666|GO:0008217|GO:0050805|GO:0048869|GO:2000145|GO:0010035|GO:0009967|GO:0044249|GO:0010033|GO:0098857|GO:0031323|GO:0016684|GO:0003013|GO:0043271|GO:0055114|GO:0009636|GO:0007584|GO:1902533|GO:0005901|GO:0042307|GO:0010574|GO:0009743|GO:0035150|GO:0002040|GO:0071498|GO:0006936|GO:0090132|GO:0048660|GO:0071636|GO:0048167|GO:0046872|GO:0020037|GO:0014074|GO:0033993|GO:0001944|GO:0072594|GO:0061458|GO:0072358|GO:0034097|GO:0004666|GO:0007612|GO:0050727|GO:0002237|GO:0006631|GO:0046683|GO:0001659|GO:0032386|GO:0051223|GO:0015031|GO:0048659|GO:0046889|GO:0031214|GO:0090257|GO:0090271|GO:0071417|GO:0010038|GO:0030334|GO:0001667|GO:0051926|GO:0048661|GO:0051968|GO:0010575|GO:0007613|GO:2000377|GO:0071456|GO:0070201|GO:0046907|GO:0045907|GO:0042886|GO:0006811|GO:0006954|GO:0046209|GO:0033273|GO:1903428|GO:0045766|GO:0007600|GO:0045765|GO:0045600|GO:0031620|GO:0051966|GO:0071478|GO:0032225|GO:0016702|GO:0050729|GO:0045428|GO:0009820|GO:0033198|GO:0090362|GO:1904591|GO:0071453|GO:0043269|GO:0034613|GO:0010565|GO:0070542|GO:0045987|GO:0012501|GO:0014070|GO:0006796|GO:0043603|GO:1901342|GO:0035556|GO:0017038|GO:0031503|GO:0005788|GO:0008610|GO:0019216|GO:0071310|GO:0050890|GO:0010594|GO:0045598|GO:0046890|GO:0031328|GO:0006809|GO:0071260|GO:0032227|GO:0045986|GO:0030154|GO:0045923|GO:0045121|GO:0030335|GO:0043068|GO:1903827|GO:0031622|GO:1902531|GO:0072359|GO:0031667|GO:0007292|GO:0008015|GO:0032496|GO:0005634|GO:0009416|GO:0042803|GO:0030282|GO:0010042|GO:0090361|GO:0043067|GO:0006690|GO:0048545|GO:0097305|GO:1903426|GO:0006606|GO:0010595|GO:0010573|GO:0042633|GO:2000379|GO:0006766|GO:1903672|GO:0019217|GO:0019372|GO:1904589|GO:0033559|GO:0043536|GO:0033280|GO:0002673|GO:0045444|GO:0033365|GO:0033157|GO:0043122|GO:0006939|GO:0043065|GO:0019233|GO:0009411|GO:0051169|GO:0006937|GO:0009117|GO:0010226|GO:0006812|GO:0001676|GO:0002675|GO:0034284|GO:0043535|GO:0002526|GO:0015833|GO:0043627|GO:0071318|GO:0006605|GO:0019229|GO:0071407|GO:0002042|GO:0016482|GO:0006886|GO:0019369|GO:0043123|GO:0006633|GO:0007249|GO:0071482|GO:0042993|GO:0032355|GO:0010631|GO:0042981|GO:0045723|GO:0045429|GO:0090335|GO:0019752|GO:0034612|GO:0042306|GO:0042345|GO:1900180|GO:0031649|GO:0090336|GO:0046456|GO:0006767|GO:0042991|GO:0031960|GO:0042304|GO:0031915|GO:0050473|GO:0006915|GO:0050880|GO:0046824|GO:0036294|GO:0006636|GO:0051384|GO:1903533|GO:0006913|GO:0006940|GO:0042346|GO:0001660|GO:0042310|GO:0019371|GO:0032787|GO:0050873|GO:0030001|GO:0042990|GO:0090049|GO:0051924|GO:0006953|GO:0043542|GO:0034644|GO:0006693|GO:0034504|GO:0046822|GO:0007268|GO:0090050|GO:0051170|GO:0019674|GO:0009750|GO:0007270|GO:0001516|GO:0031394|GO:0043534|GO:0001963|GO:0006816|GO:0035249 antioxidant activity|locomotion|developmental process|macromolecular complex|reproduction|behavior|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|oxidoreductase activity|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|response to abiotic stimulus|sexual reproduction|negative regulation of transport|cellular metabolic process|cellular localization|developmental process involved in reproduction|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|response to other organism|membrane-bounded organelle|single-organism behavior|lipid binding|cell periphery|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|peroxidase activity|biosynthetic process|regulation of developmental process|intracellular|endoplasmic reticulum membrane|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|regulation of cellular localization|maternal placenta development|positive regulation of cell proliferation|decidualization|positive regulation of cellular component movement|reactive oxygen species biosynthetic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular lipid metabolic process|cellular oxidant detoxification|placenta development|modulation of synaptic transmission|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|response to radiation|dioxygenase activity|transport|response to mechanical stimulus|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to fluid shear stress|organic acid metabolic process|response to extracellular stimulus|plasma membrane raft|multicellular organism development|regulation of epithelial cell migration|animal organ development|neurological system process|cellular nitrogen compound metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen|small molecule metabolic process|defense response|reactive nitrogen species metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell motility|cellular response to stress|embryo implantation|positive regulation of synaptic transmission|positive regulation of cell death|regulation of cytokine production|regulation of synapse structure or activity|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|enzyme binding|response to organonitrogen compound|positive regulation of heat generation|cytoplasm|muscle system process|cytokine production|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|cell-cell signaling|response to wounding|regulation of protein localization|maintenance of blood-brain barrier|positive regulation of protein transport|movement of cell or subcellular component|homeostatic process|reactive oxygen species metabolic process|neuron projection|ovulation|regulation of signal transduction|protein dimerization activity|positive regulation of blood circulation|establishment of protein localization|cofactor metabolic process|maternal process involved in female pregnancy|nicotinamide metabolic process|response to oxidative stress|multicellular organismal homeostasis|positive regulation of cytokine production|response to drug|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|angiogenesis|nucleobase-containing small molecule metabolic process|positive regulation of protein localization to nucleus|protein localization|cell communication|female pregnancy|regulation of cellular component movement|gamete generation|lipid metabolic process|cell migration|signal transduction|endoplasmic reticulum|ossification|cellular ketone metabolic process|establishment of localization in cell|response to hormone|negative regulation of muscle contraction|cell death|learning or memory|positive regulation of intracellular protein transport|positive regulation of epithelial cell migration|negative regulation of cell proliferation|response to hypoxia|regulation of blood pressure|negative regulation of synaptic transmission|cellular developmental process|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|membrane microdomain|regulation of cellular metabolic process|oxidoreductase activity, acting on peroxide as acceptor|circulatory system process|negative regulation of ion transport|oxidation-reduction process|response to toxic substance|response to nutrient|positive regulation of intracellular signal transduction|caveola|positive regulation of protein import into nucleus|regulation of vascular endothelial growth factor production|response to carbohydrate|regulation of tube size|sprouting angiogenesis|cellular response to fluid shear stress|muscle contraction|epithelium migration|regulation of smooth muscle cell proliferation|positive regulation of transforming growth factor beta production|regulation of synaptic plasticity|metal ion binding|heme binding|response to purine-containing compound|response to lipid|vasculature development|establishment of protein localization to organelle|reproductive system development|cardiovascular system development|response to cytokine|prostaglandin-endoperoxide synthase activity|learning|regulation of inflammatory response|response to molecule of bacterial origin|fatty acid metabolic process|response to organophosphorus|temperature homeostasis|regulation of intracellular transport|regulation of protein transport|protein transport|smooth muscle cell proliferation|positive regulation of lipid biosynthetic process|biomineral tissue development|regulation of muscle system process|positive regulation of fibroblast growth factor production|cellular response to organonitrogen compound|response to metal ion|regulation of cell migration|ameboidal-type cell migration|negative regulation of calcium ion transport|positive regulation of smooth muscle cell proliferation|positive regulation of synaptic transmission, glutamatergic|positive regulation of vascular endothelial growth factor production|memory|regulation of reactive oxygen species metabolic process|cellular response to hypoxia|regulation of establishment of protein localization|intracellular transport|positive regulation of vasoconstriction|amide transport|ion transport|inflammatory response|nitric oxide metabolic process|response to vitamin|positive regulation of reactive oxygen species biosynthetic process|positive regulation of angiogenesis|sensory perception|regulation of angiogenesis|positive regulation of fat cell differentiation|regulation of fever generation|regulation of synaptic transmission, glutamatergic|cellular response to radiation|regulation of synaptic transmission, dopaminergic|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|positive regulation of inflammatory response|regulation of nitric oxide biosynthetic process|alkaloid metabolic process|response to ATP|positive regulation of platelet-derived growth factor production|positive regulation of protein import|cellular response to oxygen levels|regulation of ion transport|cellular protein localization|regulation of cellular ketone metabolic process|response to fatty acid|positive regulation of smooth muscle contraction|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular amide metabolic process|regulation of vasculature development|intracellular signal transduction|protein import|protein complex localization|endoplasmic reticulum lumen|lipid biosynthetic process|regulation of lipid metabolic process|cellular response to organic substance|cognition|regulation of endothelial cell migration|regulation of fat cell differentiation|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|cellular response to mechanical stimulus|negative regulation of synaptic transmission, dopaminergic|negative regulation of smooth muscle contraction|cell differentiation|positive regulation of fatty acid metabolic process|membrane raft|positive regulation of cell migration|positive regulation of programmed cell death|regulation of cellular protein localization|positive regulation of fever generation|regulation of intracellular signal transduction|circulatory system development|response to nutrient levels|female gamete generation|blood circulation|response to lipopolysaccharide|nucleus|response to light stimulus|protein homodimerization activity|bone mineralization|response to manganese ion|regulation of platelet-derived growth factor production|regulation of programmed cell death|icosanoid metabolic process|response to steroid hormone|response to alcohol|regulation of reactive oxygen species biosynthetic process|protein import into nucleus|positive regulation of endothelial cell migration|vascular endothelial growth factor production|hair cycle|positive regulation of reactive oxygen species metabolic process|vitamin metabolic process|positive regulation of sprouting angiogenesis|regulation of fatty acid metabolic process|lipoxygenase pathway|regulation of protein import|unsaturated fatty acid metabolic process|positive regulation of blood vessel endothelial cell migration|response to vitamin D|regulation of acute inflammatory response|fat cell differentiation|protein localization to organelle|regulation of intracellular protein transport|regulation of I-kappaB kinase/NF-kappaB signaling|smooth muscle contraction|positive regulation of apoptotic process|sensory perception of pain|response to UV|nuclear transport|regulation of muscle contraction|nucleotide metabolic process|response to lithium ion|cation transport|long-chain fatty acid metabolic process|positive regulation of acute inflammatory response|response to monosaccharide|regulation of blood vessel endothelial cell migration|acute inflammatory response|peptide transport|response to estrogen|cellular response to ATP|protein targeting|regulation of vasoconstriction|cellular response to organic cyclic compound|cell migration involved in sprouting angiogenesis|cytosolic transport|intracellular protein transport|arachidonic acid metabolic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|fatty acid biosynthetic process|I-kappaB kinase/NF-kappaB signaling|cellular response to light stimulus|positive regulation of transcription factor import into nucleus|response to estradiol|epithelial cell migration|regulation of apoptotic process|positive regulation of fatty acid biosynthetic process|positive regulation of nitric oxide biosynthetic process|regulation of brown fat cell differentiation|carboxylic acid metabolic process|response to tumor necrosis factor|regulation of protein import into nucleus|regulation of NF-kappaB import into nucleus|regulation of protein localization to nucleus|heat generation|positive regulation of brown fat cell differentiation|icosanoid biosynthetic process|water-soluble vitamin metabolic process|transcription factor import into nucleus|response to corticosteroid|regulation of fatty acid biosynthetic process|positive regulation of synaptic plasticity|arachidonate 15-lipoxygenase activity|apoptotic process|regulation of blood vessel size|positive regulation of nucleocytoplasmic transport|cellular response to decreased oxygen levels|unsaturated fatty acid biosynthetic process|response to glucocorticoid|regulation of protein targeting|nucleocytoplasmic transport|regulation of smooth muscle contraction|positive regulation of NF-kappaB import into nucleus|fever generation|vasoconstriction|cyclooxygenase pathway|monocarboxylic acid metabolic process|brown fat cell differentiation|metal ion transport|regulation of transcription factor import into nucleus|regulation of cell migration involved in sprouting angiogenesis|regulation of calcium ion transport|acute-phase response|endothelial cell migration|cellular response to UV|prostaglandin metabolic process|protein localization to nucleus|regulation of nucleocytoplasmic transport|synaptic transmission|positive regulation of cell migration involved in sprouting angiogenesis|nuclear import|NAD metabolic process|response to fructose|neuron-neuron synaptic transmission|prostaglandin biosynthetic process|positive regulation of prostaglandin biosynthetic process|blood vessel endothelial cell migration|synaptic transmission, dopaminergic|calcium ion transport|synaptic transmission, glutamatergic K11987 prostaglandin-endoperoxide synthase 2[1.14.99.1] hsa01100|hsa05200|hsa05206|hsa04921|hsa04726|hsa04668|hsa04723|hsa04064|hsa05222|hsa05204|hsa05140|hsa00590|hsa04370|hsa04923|hsa04913 Metabolic pathways - Homo sapiens (human)|Pathways in cancer - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|Regulation of lipolysis in adipocytes - Homo sapiens (human)|Ovarian steroidogenesis - Homo sapiens (human) 1:186671791-186680427 178 164 188 69 79 58 1.4087234899657 1.1795835243866 1.34145670548372 0.489272603976447 0.512980404262711 0.430193203083516 1.30992123994534 0.477482070440891 1.45596160543057 1.81019383687774e-08 3.18641077866439e-07 UP ENSG00000197312 DDI2 DNA damage inducible 1 homolog 2 [Source:HGNC Symbol;Acc:HGNC:24578] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043231|GO:0008233|GO:0005737|GO:0019538|GO:0031981|GO:0006508|GO:0005654|GO:0005634|GO:0070001|GO:0004175|GO:0004190 cell|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|protein metabolic process|nuclear lumen|proteolysis|nucleoplasm|nucleus|aspartic-type peptidase activity|endopeptidase activity|aspartic-type endopeptidase activity - - - - 1:15617500-15669044 2232 3088 3257 1171 1258 1644 10.8318240577409 13.619609784401 14.2508055784042 5.09168809915118 5.00905862582283 7.47718480039424 12.9007464735154 5.85931050845608 1.13865173515747 1.81508888363035e-08 3.19314458054805e-07 UP ENSG00000176387 HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 [Source:HGNC Symbol;Acc:HGNC:5209] GO:0000003|GO:0005623|GO:0016020|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009628|GO:0043227|GO:0048037|GO:0008289|GO:0009605|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0003014|GO:1901360|GO:0009991|GO:0005496|GO:0044281|GO:0016614|GO:0043231|GO:0010243|GO:0005737|GO:0016229|GO:0042493|GO:0007565|GO:0006629|GO:0005783|GO:0009725|GO:0050662|GO:0001666|GO:0008217|GO:0000166|GO:0016021|GO:0032094|GO:0010033|GO:0050878|GO:0003013|GO:0055114|GO:0033993|GO:0003071|GO:1901652|GO:0016616|GO:0043434|GO:0045777|GO:0008202|GO:0014070|GO:0008610|GO:0031667|GO:0008015|GO:0051287|GO:0048545|GO:0003073|GO:0003084|GO:0006694|GO:0032868|GO:0002017|GO:0031960|GO:0003845|GO:0008211|GO:0051384|GO:0006704 reproduction|cell|membrane|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|response to abiotic stimulus|membrane-bounded organelle|cofactor binding|lipid binding|response to external stimulus|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|renal system process|organic cyclic compound metabolic process|response to extracellular stimulus|steroid binding|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|steroid dehydrogenase activity|response to drug|female pregnancy|lipid metabolic process|endoplasmic reticulum|response to hormone|coenzyme binding|response to hypoxia|regulation of blood pressure|nucleotide binding|integral component of membrane|response to food|response to organic substance|regulation of body fluid levels|circulatory system process|oxidation-reduction process|response to lipid|renal system process involved in regulation of systemic arterial blood pressure|response to peptide|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|response to peptide hormone|positive regulation of blood pressure|steroid metabolic process|response to organic cyclic compound|lipid biosynthetic process|response to nutrient levels|blood circulation|NAD binding|response to steroid hormone|regulation of systemic arterial blood pressure|positive regulation of systemic arterial blood pressure|steroid biosynthetic process|response to insulin|regulation of blood volume by renal aldosterone|response to corticosteroid|11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity|glucocorticoid metabolic process|response to glucocorticoid|glucocorticoid biosynthetic process K00071 corticosteroid 11-beta-dehydrogenase isozyme 2 [EC:1.1.1.-][-] hsa00140|hsa04960 Steroid hormone biosynthesis - Homo sapiens (human)|Aldosterone-regulated sodium reabsorption - Homo sapiens (human) 16:67430652-67437553 289 277 297 115 143 86 6.28434075492736 5.4742124502183 5.82280382120224 2.24056982356097 2.55131817427868 1.75262197048502 5.86045234211597 2.18150332277489 1.42568935295659 1.82401212266346e-08 3.20695276266165e-07 UP ENSG00000198925 ATG9A autophagy related 9A [Source:HGNC Symbol;Acc:HGNC:22408] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0042175|GO:0009056|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0006810|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0061024|GO:0000422|GO:0005783|GO:0044804|GO:0016236|GO:0010008|GO:0016021|GO:0005794|GO:0005768|GO:0006996|GO:0044805|GO:0005802|GO:1903008|GO:0031410|GO:0007005|GO:0015031|GO:0055037|GO:0005770|GO:0010324|GO:0034727|GO:0034613|GO:0070925|GO:0000407|GO:0000045|GO:0031902|GO:0007033|GO:0034497 cell|membrane|cellular process|metabolic process|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|catabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|transport|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|membrane organization|mitophagy|endoplasmic reticulum|nucleophagy|macroautophagy|endosome membrane|integral component of membrane|Golgi apparatus|endosome|organelle organization|late nucleophagy|trans-Golgi network|organelle disassembly|cytoplasmic vesicle|mitochondrion organization|protein transport|recycling endosome|late endosome|membrane invagination|piecemeal microautophagy of nucleus|cellular protein localization|organelle assembly|pre-autophagosomal structure|autophagosome assembly|late endosome membrane|vacuole organization|protein localization to pre-autophagosomal structure - - - - 2:219209772-219229717 2222 2367 2525 1140 1428 1162 10.605037823035 10.2670708450012 10.8653538573371 4.87495685039699 5.59196317654088 5.19760454245418 10.5791541751244 5.22150818979735 1.01868580293624 1.85407031997422e-08 3.25788200897648e-07 UP ENSG00000186919 ZACN zinc activated ligand-gated ion channel [Source:HGNC Symbol;Acc:HGNC:29504] GO:0004871|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0022857|GO:0050794|GO:0043167|GO:0038023|GO:0071944|GO:0005886|GO:0030594|GO:0006810|GO:0043169|GO:0004888|GO:0022891|GO:0007154|GO:0055085|GO:0007165|GO:0010035|GO:0007186|GO:0046872|GO:0015464|GO:0010038|GO:0015267|GO:0006811|GO:0015075|GO:0010043|GO:0004930|GO:0034220|GO:0015276|GO:0004993|GO:0098655|GO:0005216|GO:0006812|GO:0007210|GO:0046914|GO:0008227|GO:0008324|GO:0005230|GO:0005261|GO:0008270|GO:0005231|GO:0005232|GO:0004889 signal transducer activity|transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|transmembrane transporter activity|regulation of cellular process|ion binding|signaling receptor activity|cell periphery|plasma membrane|neurotransmitter receptor activity|transport|cation binding|transmembrane signaling receptor activity|substrate-specific transmembrane transporter activity|cell communication|transmembrane transport|signal transduction|response to inorganic substance|G-protein coupled receptor signaling pathway|metal ion binding|acetylcholine receptor activity|response to metal ion|channel activity|ion transport|ion transmembrane transporter activity|response to zinc ion|G-protein coupled receptor activity|ion transmembrane transport|ligand-gated ion channel activity|G-protein coupled serotonin receptor activity|cation transmembrane transport|ion channel activity|cation transport|serotonin receptor signaling pathway|transition metal ion binding|G-protein coupled amine receptor activity|cation transmembrane transporter activity|extracellular ligand-gated ion channel activity|cation channel activity|zinc ion binding|excitatory extracellular ligand-gated ion channel activity|serotonin-activated cation-selective channel activity|acetylcholine-activated cation-selective channel activity - - - - 17:76071961-76083666 22 29 53 2 9 3 0.236649124970883 0.283510064621485 0.514011045209126 0.0192764150264096 0.0794307425278952 0.0302398473438495 0.344723411600498 0.0429823349660514 3.00362351869179 1.88137755344486e-08 3.30392032238487e-07 UP ENSG00000119953 SMNDC1 survival motor neuron domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16900] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0030529|GO:0006139|GO:0008219|GO:0003723|GO:0031981|GO:0005681|GO:0005654|GO:0012501|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0016604|GO:0016071|GO:0044822|GO:0006915|GO:0016607|GO:0015030|GO:0006397|GO:0008380|GO:0000375 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|cell death|RNA binding|nuclear lumen|spliceosomal complex|nucleoplasm|programmed cell death|gene expression|RNA metabolic process|nucleus|RNA processing|nuclear body|mRNA metabolic process|poly(A) RNA binding|apoptotic process|nuclear speck|Cajal body|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions K12839 survival of motor neuron-related-splicing factor 30[-] - - 10:110290730-110304951 1130 1481 1086 598 534 605 11.6809347865797 13.9134365778739 10.1214616780476 5.53857482020258 4.52906555893461 5.86115485062078 11.9052776808337 5.30959840991932 1.16492661827074 1.90464032175007e-08 3.34280612378169e-07 UP ENSG00000123096 SSPN sarcospan [Source:HGNC Symbol;Acc:HGNC:11322] GO:0032991|GO:0045202|GO:0005623|GO:0016020|GO:0030054|GO:0043229|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0043234|GO:0012505|GO:0097060|GO:0098797|GO:0031982|GO:0045211|GO:0005887|GO:0043231|GO:0030133|GO:0005737|GO:0003012|GO:0042383|GO:0031226|GO:0016021|GO:0006936|GO:0031410|GO:0016023|GO:0016010|GO:0031988 macromolecular complex|synapse|cell|membrane|cell junction|intracellular organelle|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|protein complex|endomembrane system|synaptic membrane|plasma membrane protein complex|vesicle|postsynaptic membrane|integral component of plasma membrane|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|muscle system process|sarcolemma|intrinsic component of plasma membrane|integral component of membrane|muscle contraction|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|dystrophin-associated glycoprotein complex|membrane-bounded vesicle - - - - 12:26121991-26299290 52 48 84 177 213 281 0.351590905768617 0.29495225576327 0.512064889219696 1.07226708671798 1.18162113471279 1.78059849970388 0.386202683583861 1.34482890704488 -1.79999254648746 1.90825906202366e-08 3.34718954392799e-07 DOWN ENSG00000105287 PRKD2 protein kinase D2 [Source:HGNC Symbol;Acc:HGNC:17293] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0048520|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0050795|GO:0006914|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0008284|GO:0051272|GO:0002757|GO:0042127|GO:0002250|GO:0006935|GO:0035239|GO:0006725|GO:0009888|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0007275|GO:0010632|GO:0016570|GO:0034641|GO:0043168|GO:0030155|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0090287|GO:0001817|GO:0043231|GO:0043169|GO:0005737|GO:0001816|GO:0050920|GO:0006928|GO:0009966|GO:0048729|GO:0050673|GO:0001819|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0000422|GO:0050857|GO:0045785|GO:0008219|GO:0010634|GO:0016236|GO:0050790|GO:0000166|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0005794|GO:0050921|GO:0006996|GO:0051090|GO:0071774|GO:0000165|GO:0050679|GO:0051276|GO:1902533|GO:0032268|GO:0040036|GO:0010468|GO:0090132|GO:0034645|GO:1903008|GO:0046872|GO:0007166|GO:0030949|GO:0002009|GO:0035639|GO:0000423|GO:0001944|GO:0043412|GO:0072358|GO:0032623|GO:0051345|GO:0007005|GO:0030947|GO:0031056|GO:0050862|GO:0051252|GO:0006325|GO:0001883|GO:0031058|GO:0010628|GO:0030334|GO:0038089|GO:0001935|GO:0001667|GO:0036211|GO:0032549|GO:0032757|GO:0051091|GO:0002429|GO:0032743|GO:0045766|GO:0031981|GO:0060326|GO:0045765|GO:2001028|GO:0044344|GO:0051247|GO:0070848|GO:0005654|GO:0006259|GO:0050678|GO:0002764|GO:0016301|GO:0032270|GO:0060429|GO:0051054|GO:0006796|GO:1901342|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0060562|GO:0071310|GO:0017076|GO:0010594|GO:0045743|GO:0031328|GO:0051246|GO:0009059|GO:0030335|GO:1902531|GO:0016070|GO:0072359|GO:0016773|GO:0010557|GO:0016575|GO:0005634|GO:0010595|GO:0032637|GO:0010638|GO:2001252|GO:0003158|GO:0031063|GO:0043536|GO:0045893|GO:0031401|GO:0008543|GO:0050856|GO:0043408|GO:0032774|GO:0005524|GO:0031065|GO:2001141|GO:0090045|GO:0071363|GO:0030554|GO:0043535|GO:0016310|GO:0033044|GO:0051092|GO:0002768|GO:0070371|GO:0035767|GO:0001936|GO:2000278|GO:0007167|GO:0061154|GO:0043410|GO:0032793|GO:0010631|GO:0001938|GO:0004672|GO:0016568|GO:1901725|GO:0038033|GO:2000573|GO:0006464|GO:0098779|GO:0050851|GO:0071897|GO:0006351|GO:0006355|GO:0089700|GO:0045944|GO:0006366|GO:0090312|GO:0006357|GO:0006468|GO:1903506|GO:0090311|GO:0042325|GO:0035924|GO:0070374|GO:0001932|GO:0018193|GO:0004674|GO:0001934|GO:0050852|GO:0070372|GO:1901727|GO:0043542|GO:0042327|GO:0007169|GO:0048010|GO:0046777|GO:0033138|GO:0018105|GO:0006476|GO:0033135|GO:0004697|GO:0038084|GO:0043534 locomotion|developmental process|immune system process|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of behavior|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|regulation of behavior|autophagy|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|positive regulation of cell proliferation|positive regulation of cellular component movement|immune response-activating signal transduction|regulation of cell proliferation|adaptive immune response|chemotaxis|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|regulation of epithelial cell migration|histone modification|cellular nitrogen compound metabolic process|anion binding|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|regulation of cellular response to growth factor stimulus|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|cytoplasm|cytokine production|regulation of chemotaxis|movement of cell or subcellular component|regulation of signal transduction|tissue morphogenesis|epithelial cell proliferation|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|mitophagy|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of cell adhesion|cell death|positive regulation of epithelial cell migration|macroautophagy|regulation of catalytic activity|nucleotide binding|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|positive regulation of chemotaxis|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|response to fibroblast growth factor|MAPK cascade|positive regulation of epithelial cell proliferation|chromosome organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of fibroblast growth factor receptor signaling pathway|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|organelle disassembly|metal ion binding|cell surface receptor signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|macromitophagy|vasculature development|macromolecule modification|cardiovascular system development|interleukin-2 production|positive regulation of hydrolase activity|mitochondrion organization|regulation of vascular endothelial growth factor receptor signaling pathway|regulation of histone modification|positive regulation of T cell receptor signaling pathway|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|positive regulation of histone modification|positive regulation of gene expression|regulation of cell migration|positive regulation of cell migration by vascular endothelial growth factor signaling pathway|endothelial cell proliferation|ameboidal-type cell migration|protein modification process|ribonucleoside binding|positive regulation of interleukin-8 production|positive regulation of sequence-specific DNA binding transcription factor activity|immune response-activating cell surface receptor signaling pathway|positive regulation of interleukin-2 production|positive regulation of angiogenesis|nuclear lumen|cell chemotaxis|regulation of angiogenesis|positive regulation of endothelial cell chemotaxis|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|nucleoplasm|DNA metabolic process|regulation of epithelial cell proliferation|immune response-regulating signaling pathway|kinase activity|positive regulation of cellular protein metabolic process|epithelium development|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|epithelial tube morphogenesis|cellular response to organic substance|purine nucleotide binding|regulation of endothelial cell migration|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of cell migration|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|positive regulation of endothelial cell migration|interleukin-8 production|positive regulation of organelle organization|positive regulation of chromosome organization|endothelium development|regulation of histone deacetylation|positive regulation of blood vessel endothelial cell migration|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|regulation of T cell receptor signaling pathway|regulation of MAPK cascade|RNA biosynthetic process|ATP binding|positive regulation of histone deacetylation|regulation of RNA biosynthetic process|positive regulation of deacetylase activity|cellular response to growth factor stimulus|adenyl nucleotide binding|regulation of blood vessel endothelial cell migration|phosphorylation|regulation of chromosome organization|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|ERK1 and ERK2 cascade|endothelial cell chemotaxis|regulation of endothelial cell proliferation|regulation of DNA biosynthetic process|enzyme linked receptor protein signaling pathway|endothelial tube morphogenesis|positive regulation of MAPK cascade|positive regulation of CREB transcription factor activity|epithelial cell migration|positive regulation of endothelial cell proliferation|protein kinase activity|chromatin modification|regulation of histone deacetylase activity|positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway|positive regulation of DNA biosynthetic process|cellular protein modification process|mitophagy in response to mitochondrial depolarization|antigen receptor-mediated signaling pathway|DNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|protein kinase D signaling|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|positive regulation of protein deacetylation|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of protein deacetylation|regulation of phosphorylation|cellular response to vascular endothelial growth factor stimulus|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|T cell receptor signaling pathway|regulation of ERK1 and ERK2 cascade|positive regulation of histone deacetylase activity|endothelial cell migration|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|protein autophosphorylation|positive regulation of peptidyl-serine phosphorylation|peptidyl-serine phosphorylation|protein deacetylation|regulation of peptidyl-serine phosphorylation|protein kinase C activity|vascular endothelial growth factor signaling pathway|blood vessel endothelial cell migration K06070 protein kinase D[2.7.11.13] hsa04015|hsa04925 Rap1 signaling pathway - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human) 19:46674275-46717127 1974 2032 2244 1023 1223 1050 11.3431800838887 10.6118586817723 11.6258497784578 5.26696995438476 5.76610051866574 5.65465286138536 11.1936295147063 5.56257444481195 1.00885325947986 1.91551353514736e-08 3.35794134341101e-07 UP ENSG00000137221 TJAP1 tight junction associated protein 1 (peripheral) [Source:HGNC Symbol;Acc:HGNC:17949] GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0043229|GO:0005911|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0043231|GO:0005737|GO:0043296|GO:0010256|GO:0005794|GO:0005768|GO:0006996|GO:0005802|GO:0007030|GO:0005923 cell|membrane|cellular process|cell junction|binding|intracellular organelle|cell-cell junction|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|apical junction complex|endomembrane system organization|Golgi apparatus|endosome|organelle organization|trans-Golgi network|Golgi organization|bicellular tight junction K06105 tight junction protein 4 (peripheral)[-] hsa04530 Tight junction - Homo sapiens (human) 6:43477523-43506556 1448 1569 1350 701 757 739 7.03530255768004 6.92814953536296 5.91373725884581 3.05161555734653 3.01771520857219 3.36501825615898 6.62572978396294 3.14478300735923 1.07511889404434 1.93248747180021e-08 3.3824241614756e-07 UP ENSG00000139112 GABARAPL1 GABA(A) receptor-associated protein like 1 [Source:HGNC Symbol;Acc:HGNC:4068] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0043229|GO:0006950|GO:0009056|GO:0006914|GO:0044297|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0031252|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0009991|GO:0005102|GO:0005874|GO:0031982|GO:0033554|GO:0032839|GO:0022607|GO:0043231|GO:0019899|GO:0005774|GO:0005737|GO:0031668|GO:0012506|GO:0043005|GO:0036477|GO:0032838|GO:0007154|GO:0000422|GO:0005783|GO:0032589|GO:0008134|GO:0008092|GO:0031256|GO:0016236|GO:0031253|GO:0042594|GO:0005794|GO:0006996|GO:0015631|GO:0005829|GO:1903008|GO:0031410|GO:0007005|GO:0032590|GO:0005773|GO:0000421|GO:0016023|GO:0050811|GO:0030425|GO:0031988|GO:0005739|GO:0009267|GO:0030957|GO:0070925|GO:0030659|GO:0031669|GO:0000045|GO:0031667|GO:0005856|GO:0007033|GO:0044389|GO:0031625|GO:0006995|GO:0048487|GO:0005776|GO:0015630 cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|intracellular organelle|response to stress|catabolic process|autophagy|cell body|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|cell leading edge|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|response to extracellular stimulus|receptor binding|microtubule|vesicle|cellular response to stress|dendrite cytoplasm|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|vacuolar membrane|cytoplasm|cellular response to extracellular stimulus|vesicle membrane|neuron projection|somatodendritic compartment|cell projection cytoplasm|cell communication|mitophagy|endoplasmic reticulum|neuron projection membrane|transcription factor binding|cytoskeletal protein binding|leading edge membrane|macroautophagy|cell projection membrane|response to starvation|Golgi apparatus|organelle organization|tubulin binding|cytosol|organelle disassembly|cytoplasmic vesicle|mitochondrion organization|dendrite membrane|vacuole|autophagosome membrane|cytoplasmic, membrane-bounded vesicle|GABA receptor binding|dendrite|membrane-bounded vesicle|mitochondrion|cellular response to starvation|Tat protein binding|organelle assembly|cytoplasmic vesicle membrane|cellular response to nutrient levels|autophagosome assembly|response to nutrient levels|cytoskeleton|vacuole organization|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular response to nitrogen starvation|beta-tubulin binding|autophagosome|microtubule cytoskeleton K08341 GABA(A) receptor-associated protein[-] hsa04068|hsa04727|hsa04140 FoxO signaling pathway - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Regulation of autophagy - Homo sapiens (human) 12:10212458-10223130 882 946 1395 271 473 556 3.97185625172098 3.87164811663582 5.66387062116192 1.09343022239864 1.74764768858011 2.34654497934414 4.50245832983957 1.72920763010763 1.38060181684521 1.93228885292584e-08 3.3824241614756e-07 UP ENSG00000170959 DCDC1 doublecortin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:20625] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0005622|GO:0007154|GO:0007165|GO:0035556 signaling|cell|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|intracellular|cell communication|signal transduction|intracellular signal transduction - - - - 11:30830369-31369810 1 3 4 19 26 34 0.0040600512577518 0.0110666856508938 0.0146363860003932 0.0690880172360205 0.0865751338126734 0.129317120472979 0.0099210409696796 0.0949934238405576 -3.25926423360416 1.9328785487631e-08 3.3824241614756e-07 DOWN ENSG00000168785 TSPAN5 tetraspanin 5 [Source:HGNC Symbol;Acc:HGNC:17753] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0051641|GO:0023051|GO:0016043|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0005887|GO:0019899|GO:0009966|GO:0045184|GO:0010646|GO:0031226|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0016021|GO:0009967|GO:0019538|GO:0010256|GO:0090150|GO:0007166|GO:0051604|GO:0007009|GO:0072657|GO:0045747|GO:0008593|GO:0034613|GO:0010467|GO:0072659|GO:0090002|GO:0007219|GO:1990778 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular localization|regulation of signaling|cellular component organization|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|integral component of plasma membrane|enzyme binding|regulation of signal transduction|establishment of protein localization|regulation of cell communication|intrinsic component of plasma membrane|protein localization|cell communication|membrane organization|signal transduction|integral component of membrane|positive regulation of signal transduction|protein metabolic process|endomembrane system organization|establishment of protein localization to membrane|cell surface receptor signaling pathway|protein maturation|plasma membrane organization|protein localization to membrane|positive regulation of Notch signaling pathway|regulation of Notch signaling pathway|cellular protein localization|gene expression|protein localization to plasma membrane|establishment of protein localization to plasma membrane|Notch signaling pathway|protein localization to cell periphery - - - - 4:98470367-98658629 170 156 339 603 690 817 1.19976412139871 1.00058057710614 2.15705799320354 3.81296415230713 3.99544117242553 5.40379363280797 1.4524675639028 4.40406631918021 -1.60033024793892 1.93485612179182e-08 3.38390126889122e-07 DOWN ENSG00000129003 VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23594] GO:0016020|GO:0005576|GO:1903561|GO:0019898|GO:0043227|GO:0031982|GO:0070062 membrane|extracellular region|extracellular vesicle|extrinsic component of membrane|membrane-bounded organelle|vesicle|extracellular exosome - - - - 15:61852389-62060473 256 358 626 1076 1144 1556 0.708670352094311 0.900671316256677 1.56239942771036 2.66878601922751 2.59835160378332 4.03684870229732 1.05724703202045 3.10132877510272 -1.5525739653304 1.9409345706052e-08 3.39254453576392e-07 DOWN ENSG00000116539 ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) [Source:HGNC Symbol;Acc:HGNC:19088] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0032259|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0005911|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0006952|GO:0031982|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0001816|GO:0007267|GO:0009611|GO:0009966|GO:0003682|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0044249|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0043296|GO:0005794|GO:0006996|GO:0000165|GO:0051276|GO:0032268|GO:0003677|GO:0008168|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0032635|GO:0050727|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0010628|GO:0036211|GO:0032269|GO:0006954|GO:0031981|GO:0050728|GO:0005654|GO:0005694|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:1902532|GO:0031328|GO:0051246|GO:0009059|GO:0005923|GO:1902531|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0043124|GO:0002673|GO:0043122|GO:0043408|GO:0032774|GO:2001141|GO:0016310|GO:0002526|GO:0018022|GO:0007249|GO:0008276|GO:0034968|GO:0046914|GO:0043409|GO:0016568|GO:0006464|GO:0008757|GO:0071103|GO:0006351|GO:0008170|GO:0006355|GO:0002674|GO:0006323|GO:0045944|GO:0006366|GO:0006357|GO:0016279|GO:0051568|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0018193|GO:0042054|GO:0042326|GO:0018027|GO:0001933|GO:0008270|GO:0010452|GO:0097676|GO:0018024|GO:0018205|GO:0042800|GO:0046975 signaling|cell|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|methylation|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|cell-cell junction|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|endomembrane system|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cytokine production|cell-cell signaling|response to wounding|regulation of signal transduction|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|apical junction complex|Golgi apparatus|organelle organization|MAPK cascade|chromosome organization|regulation of cellular protein metabolic process|DNA binding|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|interleukin-6 production|regulation of inflammatory response|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|inflammatory response|nuclear lumen|negative regulation of inflammatory response|nucleoplasm|chromosome|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|bicellular tight junction|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of acute inflammatory response|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of MAPK cascade|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorylation|acute inflammatory response|peptidyl-lysine methylation|I-kappaB kinase/NF-kappaB signaling|protein methyltransferase activity|histone lysine methylation|transition metal ion binding|negative regulation of MAPK cascade|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|DNA conformation change|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|negative regulation of acute inflammatory response|DNA packaging|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|protein-lysine N-methyltransferase activity|histone H3-K4 methylation|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|histone methyltransferase activity|negative regulation of phosphorylation|peptidyl-lysine dimethylation|negative regulation of protein phosphorylation|zinc ion binding|histone H3-K36 methylation|histone H3-K36 dimethylation|histone-lysine N-methyltransferase activity|peptidyl-lysine modification|histone methyltransferase activity (H3-K4 specific)|histone methyltransferase activity (H3-K36 specific) K06101 histone-lysine N-methyltransferase ASH1L[2.1.1.43] hsa04530|hsa00310 Tight junction - Homo sapiens (human)|Lysine degradation - Homo sapiens (human) 1:155335268-155562807 634 872 933 1901 2043 1858 2.58828031387733 3.23533146316525 3.43414058559594 6.95347892301771 6.84319091859075 7.10881041612156 3.08591745421284 6.96849341924334 -1.17514730919178 1.94716290420626e-08 3.40143951680361e-07 DOWN ENSG00000204256 BRD2 bromodomain containing 2 [Source:HGNC Symbol;Acc:HGNC:1103] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0016043|GO:0043227|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0048609|GO:0019222|GO:0006725|GO:0042393|GO:1901360|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0003682|GO:0006139|GO:0007276|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0048232|GO:0070577|GO:0051252|GO:0006325|GO:0006461|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0007283|GO:0006334|GO:0034622|GO:0032774|GO:2001141|GO:0034728|GO:0006333|GO:0065004|GO:0031497|GO:0016568|GO:0071103|GO:0006351|GO:0006355|GO:0006323|GO:0006366|GO:0006357|GO:1903506 reproduction|cell|cellular process|reproductive process|metabolic process|binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|multicellular organismal reproductive process|regulation of metabolic process|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|chromatin binding|nucleobase-containing compound metabolic process|gamete generation|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|male gamete generation|lysine-acetylated histone binding|regulation of RNA metabolic process|chromatin organization|protein complex assembly|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|spermatogenesis|nucleosome assembly|cellular macromolecular complex assembly|RNA biosynthetic process|regulation of RNA biosynthetic process|nucleosome organization|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|chromatin modification|DNA conformation change|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA packaging|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 6:32968660-32981505 8643 8369 6716 3695 4139 3545 39.9855228017359 35.1877783431565 28.0132276150983 15.3161760485982 15.7109190558397 15.3703363875526 34.3955095866636 15.4658104973302 1.15313778912862 1.95315255145449e-08 3.40990738427617e-07 UP ENSG00000282034 RP11-2C24.9 - GO:0005488|GO:0036094|GO:0097159|GO:0043167|GO:0003676|GO:0043168|GO:0001882|GO:0000166|GO:0003677|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005524|GO:0030554 binding|small molecule binding|organic cyclic compound binding|ion binding|nucleic acid binding|anion binding|nucleoside binding|nucleotide binding|DNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|ATP binding|adenyl nucleotide binding - - - - 16:30704067-30745169 1803 1856 2222 975 1139 672 10.9081888770499 10.2050474860332 12.1203524099591 5.28517340487276 5.65390682828012 3.81026271956109 11.0778629243474 4.91644765090466 1.17199140541692 1.9662026784465e-08 3.43068467342735e-07 UP ENSG00000244151 RP11-148K1.12 - - - - - - - 7:151074742-151076530 329 335 240 85 140 65 18.9206792809781 17.5091679846717 12.4441723488527 4.37984729760231 6.60598746412467 3.50336388906902 16.2913398715008 4.82973288359867 1.75408995659956 1.98243356787361e-08 3.45698433033288e-07 UP ENSG00000260257 RP5-1085F17.3 - - - - - - - 20:32856621-32858751 78 58 65 20 21 12 2.5891520195929 1.74972478676022 1.94531828120872 0.594816017796644 0.571940256748476 0.373298667894425 2.09473169585395 0.513351647479848 2.0287461476825 2.01248581939546e-08 3.50734101881099e-07 UP ENSG00000099942 CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like [Source:HGNC Symbol;Acc:HGNC:2363] GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0060090|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0043227|GO:0009893|GO:0005622|GO:0002520|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0007507|GO:0035591|GO:0008284|GO:0042127|GO:0001568|GO:0007275|GO:0003676|GO:0048513|GO:0031982|GO:0031325|GO:0033554|GO:0043231|GO:0005737|GO:0007389|GO:0009887|GO:0009966|GO:0030674|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0070062|GO:0050790|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0048732|GO:0005768|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0048538|GO:0003723|GO:0007166|GO:0001944|GO:0043412|GO:0072358|GO:0051347|GO:0036211|GO:0003002|GO:0035270|GO:0031098|GO:0051247|GO:0070848|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0060017|GO:0071310|GO:0051246|GO:1902531|GO:0072359|GO:0005070|GO:0031401|GO:0043408|GO:0071363|GO:0016310|GO:0038179|GO:0007167|GO:0043410|GO:0009952|GO:0044822|GO:0007264|GO:0006464|GO:0051403|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:0045860|GO:0006468|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0001934|GO:0042327|GO:0007169|GO:0071900|GO:0032147 developmental process|signal transducer activity|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|binding, bridging|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|intracellular|immune system development|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|heart development|signaling adaptor activity|positive regulation of cell proliferation|regulation of cell proliferation|blood vessel development|multicellular organism development|nucleic acid binding|animal organ development|vesicle|positive regulation of cellular metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|organ morphogenesis|regulation of signal transduction|protein binding, bridging|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|extracellular exosome|regulation of catalytic activity|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|gland development|endosome|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|thymus development|RNA binding|cell surface receptor signaling pathway|vasculature development|macromolecule modification|cardiovascular system development|positive regulation of transferase activity|protein modification process|regionalization|endocrine system development|stress-activated protein kinase signaling cascade|positive regulation of protein metabolic process|response to growth factor|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|parathyroid gland development|cellular response to organic substance|regulation of protein metabolic process|regulation of intracellular signal transduction|circulatory system development|SH3/SH2 adaptor activity|positive regulation of protein modification process|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|neurotrophin signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|anterior/posterior pattern specification|poly(A) RNA binding|small GTPase mediated signal transduction|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity K04438 proto-oncogene C-crk[-] hsa05200|hsa05206|hsa04010|hsa04810|hsa04015|hsa04510|hsa04062|hsa04910|hsa04722|hsa04666|hsa04012|hsa05100|hsa05220|hsa05211|hsa05131 Pathways in cancer - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Shigellosis - Homo sapiens (human) 22:20917426-20953749 5380 5694 6875 2885 3236 3289 55.1862326471119 53.0818423481362 63.5821819726063 26.5150191942076 27.2348499392695 31.6185001517504 57.2834189892848 28.4561230950758 1.00937848282657 2.01419907478795e-08 3.50827883189728e-07 UP ENSG00000135636 DYSF dysferlin [Source:HGNC Symbol;Acc:HGNC:3097] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0042995|GO:0043229|GO:0006950|GO:0043167|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0031252|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0043168|GO:0005543|GO:0031982|GO:0030315|GO:0043231|GO:0043169|GO:0005737|GO:0009611|GO:0012506|GO:0030027|GO:0042383|GO:0061024|GO:0070062|GO:0016021|GO:0010256|GO:0005768|GO:0006996|GO:0061025|GO:0016192|GO:0046872|GO:0016050|GO:0031410|GO:0005769|GO:0007009|GO:0016023|GO:0042060|GO:0005770|GO:0031988|GO:0005544|GO:0030659|GO:0048284|GO:0030139|GO:0005509|GO:0006906|GO:0001778 cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cell projection|intracellular organelle|response to stress|ion binding|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|cell leading edge|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|transport|anion binding|phospholipid binding|vesicle|T-tubule|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to wounding|vesicle membrane|lamellipodium|sarcolemma|membrane organization|extracellular exosome|integral component of membrane|endomembrane system organization|endosome|organelle organization|membrane fusion|vesicle-mediated transport|metal ion binding|vesicle organization|cytoplasmic vesicle|early endosome|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|wound healing|late endosome|membrane-bounded vesicle|calcium-dependent phospholipid binding|cytoplasmic vesicle membrane|organelle fusion|endocytic vesicle|calcium ion binding|vesicle fusion|plasma membrane repair - - - - 2:71453722-71686768 31 47 61 162 163 148 0.221364813528817 0.305020555458726 0.392727745736818 1.0364806714362 0.955000767395934 0.99045922679781 0.306371038241454 0.993980221876648 -1.69793722209364 2.04066929249772e-08 3.55231143196658e-07 DOWN ENSG00000128654 MTX2 metaxin 2 [Source:HGNC Symbol;Acc:HGNC:7506] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0019867|GO:0005622|GO:0005515|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0031966|GO:0045184|GO:0008104|GO:0051649|GO:0019538|GO:0006996|GO:0005740|GO:0072594|GO:0007005|GO:0005741|GO:0015031|GO:0046907|GO:0005739|GO:0034613|GO:0044267|GO:0006626|GO:0033365|GO:0006839|GO:0006605|GO:0072655|GO:0006886|GO:0070585 cell|membrane|cellular process|metabolic process|binding|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|outer membrane|intracellular|protein binding|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|establishment of protein localization|protein localization|establishment of localization in cell|protein metabolic process|organelle organization|mitochondrial envelope|establishment of protein localization to organelle|mitochondrion organization|mitochondrial outer membrane|protein transport|intracellular transport|mitochondrion|cellular protein localization|cellular protein metabolic process|protein targeting to mitochondrion|protein localization to organelle|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|intracellular protein transport|protein localization to mitochondrion - - - - 2:176269395-176338025 291 327 439 965 905 764 6.94013068161667 7.08765279990344 9.43960349590121 20.6205121118355 17.7088852453658 17.0764180634231 7.82246232580711 18.4686051402081 -1.23938019910313 2.11121380644997e-08 3.67297068634949e-07 DOWN ENSG00000106638 TBL2 transducin (beta)-like 2 [Source:HGNC Symbol;Acc:HGNC:11586] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0009628|GO:0043227|GO:0009605|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0051219|GO:0009991|GO:0003676|GO:0033554|GO:0043231|GO:0031227|GO:0019899|GO:0005737|GO:0031668|GO:0030176|GO:0007154|GO:0007165|GO:0005783|GO:0001666|GO:0016021|GO:0031301|GO:0010033|GO:0042594|GO:0031369|GO:0003723|GO:0030968|GO:0071456|GO:0006986|GO:0009267|GO:0071453|GO:0019900|GO:0071310|GO:0031669|GO:0035967|GO:0031667|GO:0034976|GO:0034620|GO:0042149|GO:0044822|GO:0019901|GO:0036294 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|response to abiotic stimulus|membrane-bounded organelle|response to external stimulus|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|phosphoprotein binding|response to extracellular stimulus|nucleic acid binding|cellular response to stress|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|enzyme binding|cytoplasm|cellular response to extracellular stimulus|integral component of endoplasmic reticulum membrane|cell communication|signal transduction|endoplasmic reticulum|response to hypoxia|integral component of membrane|integral component of organelle membrane|response to organic substance|response to starvation|translation initiation factor binding|RNA binding|endoplasmic reticulum unfolded protein response|cellular response to hypoxia|response to unfolded protein|cellular response to starvation|cellular response to oxygen levels|kinase binding|cellular response to organic substance|cellular response to nutrient levels|cellular response to topologically incorrect protein|response to nutrient levels|response to endoplasmic reticulum stress|cellular response to unfolded protein|cellular response to glucose starvation|poly(A) RNA binding|protein kinase binding|cellular response to decreased oxygen levels - - - - 7:73568932-73578791 681 908 868 371 309 451 3.08121888892724 3.73371697179934 3.54086482470034 1.50399736724351 1.14710292849922 1.91240939958566 3.45193356180897 1.5211698984428 1.18222340202311 2.11471803141923e-08 3.67575151491036e-07 UP ENSG00000136944 LMX1B LIM homeobox transcription factor 1, beta [Source:HGNC Symbol;Acc:HGNC:6654] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0007389|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0009790|GO:0003002|GO:0010467|GO:0007399|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0030182|GO:0009792|GO:0032774|GO:0043565|GO:2001141|GO:0009953|GO:0046914|GO:0022008|GO:0006351|GO:0006355|GO:0048699|GO:1903506|GO:0043009|GO:0008270|GO:0001701 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|pattern specification process|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|embryo development|regionalization|gene expression|nervous system development|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|neuron differentiation|embryo development ending in birth or egg hatching|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|dorsal/ventral pattern formation|transition metal ion binding|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|generation of neurons|regulation of nucleic acid-templated transcription|chordate embryonic development|zinc ion binding|in utero embryonic development - - - - 9:126614443-126701032 2 0 6 20 38 27 0.0215159126838525 0 0.0582005037232367 0.192783716186258 0.335433111273378 0.272232193984729 0.0265721388023631 0.266816340481455 -3.3278607626494 2.11527470443358e-08 3.67575151491036e-07 DOWN ENSG00000048392 RRM2B ribonucleotide reductase M2 B (TP53 inducible) [Source:HGNC Symbol;Acc:HGNC:17296] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0023057|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0006281|GO:0003014|GO:0006725|GO:0001822|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0009966|GO:0006979|GO:0060548|GO:0010646|GO:0006139|GO:0005971|GO:0055086|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0008219|GO:0016021|GO:0044249|GO:0010033|GO:0006996|GO:0055114|GO:0005829|GO:0009262|GO:0034645|GO:0046872|GO:0015949|GO:0001655|GO:0007005|GO:0043069|GO:2001234|GO:0072001|GO:0031981|GO:0005654|GO:0006259|GO:0012501|GO:0006796|GO:0035556|GO:1901137|GO:0014075|GO:0010467|GO:1902532|GO:0009059|GO:1902531|GO:0016070|GO:0005634|GO:0043067|GO:0006974|GO:0097190|GO:0000002|GO:0097193|GO:2001242|GO:0006260|GO:1901797|GO:0009117|GO:0072331|GO:0032774|GO:2001243|GO:0009132|GO:0009263|GO:0032042|GO:1901796|GO:0042981|GO:0043066|GO:0009165|GO:0006351|GO:0006915|GO:0004748|GO:0006366|GO:0072332|GO:0006352|GO:0006261|GO:0009200|GO:0006264|GO:1902254|GO:1902253|GO:0009186|GO:0006367 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|protein complex|anatomical structure development|DNA repair|renal system process|cellular aromatic compound metabolic process|kidney development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|regulation of signal transduction|response to oxidative stress|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|ribonucleoside-diphosphate reductase complex|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|cell death|integral component of membrane|cellular biosynthetic process|response to organic substance|organelle organization|oxidation-reduction process|cytosol|deoxyribonucleotide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|nucleobase-containing small molecule interconversion|urogenital system development|mitochondrion organization|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|renal system development|nuclear lumen|nucleoplasm|DNA metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|response to amine|gene expression|negative regulation of intracellular signal transduction|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|mitochondrial genome maintenance|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|DNA replication|negative regulation of signal transduction by p53 class mediator|nucleotide metabolic process|signal transduction by p53 class mediator|RNA biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway|nucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|mitochondrial DNA metabolic process|regulation of signal transduction by p53 class mediator|regulation of apoptotic process|negative regulation of apoptotic process|nucleotide biosynthetic process|transcription, DNA-templated|apoptotic process|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|transcription from RNA polymerase II promoter|intrinsic apoptotic signaling pathway by p53 class mediator|DNA-templated transcription, initiation|DNA-dependent DNA replication|deoxyribonucleoside triphosphate metabolic process|mitochondrial DNA replication|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|deoxyribonucleoside diphosphate metabolic process|transcription initiation from RNA polymerase II promoter K10808 ribonucleoside-diphosphate reductase subunit M2[1.17.4.1] hsa01100|hsa00230|hsa00240|hsa04115|hsa00480 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human)|Glutathione metabolism - Homo sapiens (human) 8:102204502-102239118 827 922 1147 428 508 542 5.84409654220897 5.92137396265912 7.30784448672816 2.70990082525041 2.94539371003343 3.58954915751737 6.35777166386542 3.08161456426707 1.04483477700044 2.12883412742484e-08 3.69716195695994e-07 UP ENSG00000103657 HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [Source:HGNC Symbol;Acc:HGNC:4867] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0016874|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0005085|GO:0048856|GO:0048646|GO:0019222|GO:0010507|GO:0010506|GO:0021692|GO:0048468|GO:0006810|GO:0021697|GO:0007275|GO:0048513|GO:0050877|GO:0021587|GO:0030902|GO:0007420|GO:0043231|GO:0005737|GO:0060322|GO:0005086|GO:0043085|GO:0021696|GO:0021695|GO:0022037|GO:0021694|GO:0019787|GO:0050790|GO:0030030|GO:0021549|GO:0048869|GO:0019538|GO:0021680|GO:0031324|GO:0031323|GO:0021575|GO:0005794|GO:0005829|GO:0031175|GO:0050905|GO:0043412|GO:0007417|GO:0051345|GO:0004842|GO:0036211|GO:0021533|GO:0021702|GO:0044267|GO:0007399|GO:0030154|GO:0048666|GO:0030182|GO:0021953|GO:0043087|GO:0043547|GO:0050885|GO:0022008|GO:0006464|GO:0048699|GO:0032446|GO:0016567 developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|ligase activity|intracellular|protein binding|endomembrane system|transferase activity|guanyl-nucleotide exchange factor activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|negative regulation of autophagy|regulation of autophagy|cerebellar Purkinje cell layer morphogenesis|cell development|transport|cerebellar cortex formation|multicellular organism development|animal organ development|neurological system process|cerebellum morphogenesis|hindbrain development|brain development|intracellular membrane-bounded organelle|cytoplasm|head development|ARF guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|cerebellar cortex morphogenesis|cerebellar cortex development|metencephalon development|cerebellar Purkinje cell layer formation|ubiquitin-like protein transferase activity|regulation of catalytic activity|cell projection organization|cerebellum development|cellular developmental process|protein metabolic process|cerebellar Purkinje cell layer development|negative regulation of cellular metabolic process|regulation of cellular metabolic process|hindbrain morphogenesis|Golgi apparatus|cytosol|neuron projection development|neuromuscular process|macromolecule modification|central nervous system development|positive regulation of hydrolase activity|ubiquitin-protein transferase activity|protein modification process|cell differentiation in hindbrain|cerebellar Purkinje cell differentiation|cellular protein metabolic process|nervous system development|cell differentiation|neuron development|neuron differentiation|central nervous system neuron differentiation|regulation of GTPase activity|positive regulation of GTPase activity|neuromuscular process controlling balance|neurogenesis|cellular protein modification process|generation of neurons|protein modification by small protein conjugation|protein ubiquitination K10594 E3 ubiquitin-protein ligase HERC1[2.3.2.26] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 15:63608618-63833942 294 365 690 1161 1268 1576 0.995246048095042 1.12293719771814 2.10593994811058 3.52137736051739 3.52184055317249 4.99997371893465 1.40804106464125 4.01439721087484 -1.51149396361192 2.13146672577363e-08 3.69958183902593e-07 DOWN ENSG00000069275 NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 [Source:HGNC Symbol;Acc:HGNC:29923] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:1900076|GO:0043231|GO:0010243|GO:0005737|GO:0000981|GO:0042592|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:1900078|GO:0007165|GO:0009725|GO:0009967|GO:0044249|GO:0010033|GO:0031323|GO:0000982|GO:0010468|GO:0034645|GO:0003723|GO:0007166|GO:0046628|GO:0048878|GO:0051252|GO:1901652|GO:0071417|GO:0010628|GO:0043434|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0001228|GO:0046626|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0045893|GO:1901653|GO:0032774|GO:2001141|GO:0001077|GO:0007167|GO:0071375|GO:0044822|GO:0032868|GO:0006351|GO:0006355|GO:0033500|GO:0042593|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0032869|GO:0007169|GO:0008286 signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular response to insulin stimulus|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|homeostatic process|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|positive regulation of cellular response to insulin stimulus|signal transduction|response to hormone|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|cell surface receptor signaling pathway|positive regulation of insulin receptor signaling pathway|chemical homeostasis|regulation of RNA metabolic process|response to peptide|cellular response to organonitrogen compound|positive regulation of gene expression|response to peptide hormone|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of insulin receptor signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|cellular response to peptide|RNA biosynthetic process|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|poly(A) RNA binding|response to insulin|transcription, DNA-templated|regulation of transcription, DNA-templated|carbohydrate homeostasis|glucose homeostasis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|cellular response to insulin stimulus|transmembrane receptor protein tyrosine kinase signaling pathway|insulin receptor signaling pathway - - - - 1:205712819-205750276 5028 5993 5573 13843 14705 11690 52.8948423171622 57.2983817042009 52.8592860099185 130.480599655198 126.926126156405 115.255454577793 54.3508366770939 124.220726796465 -1.19253176451793 2.14274715990208e-08 3.71700021567209e-07 DOWN ENSG00000155530 LRGUK leucine-rich repeats and guanylate kinase domain containing [Source:HGNC Symbol;Acc:HGNC:21964] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0044702|GO:0043167|GO:0019953|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0032504|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0048609|GO:0043168|GO:0001882|GO:0016772|GO:0031982|GO:0022607|GO:0030141|GO:0043231|GO:0005737|GO:0007276|GO:0001669|GO:0000166|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0048232|GO:0035639|GO:0007010|GO:0031410|GO:0001883|GO:0035082|GO:0016023|GO:0044782|GO:0002177|GO:0032549|GO:0031981|GO:0030031|GO:0031988|GO:0005654|GO:0016301|GO:0070925|GO:0006796|GO:0042384|GO:0032990|GO:0017076|GO:0030154|GO:0048858|GO:0000226|GO:0005856|GO:0005634|GO:0060271|GO:0007283|GO:0005524|GO:0030554|GO:0016310|GO:0015630|GO:0001578 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|single organism reproductive process|ion binding|sexual reproduction|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|cellular component assembly|secretory granule|intracellular membrane-bounded organelle|cytoplasm|gamete generation|acrosomal vesicle|nucleotide binding|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|male gamete generation|purine ribonucleoside triphosphate binding|cytoskeleton organization|cytoplasmic vesicle|purine nucleoside binding|axoneme assembly|cytoplasmic, membrane-bounded vesicle|cilium organization|manchette|ribonucleoside binding|nuclear lumen|cell projection assembly|membrane-bounded vesicle|nucleoplasm|kinase activity|organelle assembly|phosphate-containing compound metabolic process|cilium assembly|cell part morphogenesis|purine nucleotide binding|cell differentiation|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|nucleus|cilium morphogenesis|spermatogenesis|ATP binding|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|microtubule bundle formation - - - - 7:134127299-134264591 3 1 3 23 21 33 0.0596833012707942 0.0180870997572945 0.0537966203074442 0.409934631847912 0.342745975008718 0.61521700350571 0.043855673778511 0.45596587012078 -3.3780904331623 2.15613102295888e-08 3.73804503829352e-07 DOWN ENSG00000004864 SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 [Source:HGNC Symbol;Acc:HGNC:10983] GO:0005215|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0022857|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0003735|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005886|GO:0031090|GO:0006725|GO:0019866|GO:0006810|GO:1901360|GO:0034641|GO:0015980|GO:0044281|GO:0019637|GO:0046483|GO:0005887|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0031966|GO:0022891|GO:0006139|GO:0031226|GO:0055086|GO:0055085|GO:0051649|GO:0006091|GO:0016021|GO:0022900|GO:0010035|GO:0044249|GO:0019538|GO:0055114|GO:0005740|GO:0034645|GO:0006518|GO:0046872|GO:0019693|GO:1903825|GO:0010038|GO:0009116|GO:0046907|GO:0022904|GO:0006811|GO:0015075|GO:0005743|GO:0005996|GO:0005739|GO:0006796|GO:0043603|GO:1901137|GO:0044267|GO:0010467|GO:0045333|GO:0009059|GO:0016051|GO:0034220|GO:0009142|GO:0019318|GO:0043043|GO:0006820|GO:0015711|GO:0098656|GO:0009124|GO:0009259|GO:0009117|GO:0046390|GO:0006839|GO:0008509|GO:0051592|GO:0005509|GO:0046942|GO:0006412|GO:0046943|GO:0006163|GO:0043490|GO:0006865|GO:0009165|GO:0042278|GO:0019319|GO:0006164|GO:0015171|GO:0006835|GO:0003333|GO:0006006|GO:0015807|GO:0008514|GO:0005310|GO:0009156|GO:0046034|GO:0015813|GO:0015810|GO:0005313|GO:0009152|GO:1902475|GO:0006094|GO:0009168|GO:0015179|GO:0089711|GO:0015183|GO:0089712|GO:0006754 transporter activity|structural molecule activity|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|structural constituent of ribosome|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|plasma membrane|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|mitochondrial membrane|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|nucleobase-containing small molecule metabolic process|transmembrane transport|establishment of localization in cell|generation of precursor metabolites and energy|integral component of membrane|electron transport chain|response to inorganic substance|cellular biosynthetic process|protein metabolic process|oxidation-reduction process|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|ribose phosphate metabolic process|organic acid transmembrane transport|response to metal ion|nucleoside metabolic process|intracellular transport|respiratory electron transport chain|ion transport|ion transmembrane transporter activity|mitochondrial inner membrane|monosaccharide metabolic process|mitochondrion|phosphate-containing compound metabolic process|cellular amide metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|gene expression|cellular respiration|macromolecule biosynthetic process|carbohydrate biosynthetic process|ion transmembrane transport|nucleoside triphosphate biosynthetic process|hexose metabolic process|peptide biosynthetic process|anion transport|organic anion transport|anion transmembrane transport|nucleoside monophosphate biosynthetic process|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|mitochondrial transport|anion transmembrane transporter activity|response to calcium ion|calcium ion binding|carboxylic acid transport|translation|carboxylic acid transmembrane transporter activity|purine nucleotide metabolic process|malate-aspartate shuttle|amino acid transport|nucleotide biosynthetic process|purine nucleoside metabolic process|hexose biosynthetic process|purine nucleotide biosynthetic process|amino acid transmembrane transporter activity|dicarboxylic acid transport|amino acid transmembrane transport|glucose metabolic process|L-amino acid transport|organic anion transmembrane transporter activity|dicarboxylic acid transmembrane transporter activity|ribonucleoside monophosphate biosynthetic process|ATP metabolic process|L-glutamate transport|aspartate transport|L-glutamate transmembrane transporter activity|purine ribonucleotide biosynthetic process|L-alpha-amino acid transmembrane transport|gluconeogenesis|purine ribonucleoside monophosphate biosynthetic process|L-amino acid transmembrane transporter activity|L-glutamate transmembrane transport|L-aspartate transmembrane transporter activity|L-aspartate transmembrane transport|ATP biosynthetic process - - - - 7:96120220-96322147 333 380 264 1167 1221 687 3.63901896607381 3.77402064566077 2.6011028099268 11.4263844339583 10.947725791898 7.03599859899195 3.33804747388713 9.80336960828275 -1.55427324380661 2.16326077146667e-08 3.74671478837381e-07 DOWN ENSG00000242366 UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 [Source:HGNC Symbol;Acc:HGNC:12540] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0008144|GO:0044237|GO:0042445|GO:0043227|GO:0008289|GO:0031224|GO:0030234|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0042802|GO:0019840|GO:0044262|GO:0044255|GO:0004857|GO:0006725|GO:0005504|GO:1901360|GO:0006082|GO:0009410|GO:0005496|GO:0043168|GO:0044281|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0005975|GO:0043177|GO:0046983|GO:0044092|GO:0009812|GO:0006629|GO:0005783|GO:0016757|GO:0042180|GO:0006805|GO:0017144|GO:0050790|GO:0045833|GO:0043086|GO:0010817|GO:0016021|GO:0031324|GO:0031323|GO:0006109|GO:0042573|GO:0046982|GO:0006720|GO:0008194|GO:0006631|GO:0052696|GO:0005501|GO:0052697|GO:0051552|GO:0016758|GO:0071466|GO:0005996|GO:0045939|GO:0010565|GO:0008202|GO:0031406|GO:0009804|GO:0019216|GO:0045922|GO:0042803|GO:0019217|GO:0019218|GO:2001030|GO:0015020|GO:1904224|GO:0019752|GO:0001972|GO:0016101|GO:0032787|GO:0052695|GO:0001523 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|drug binding|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|lipid binding|intrinsic component of membrane|enzyme regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|identical protein binding|isoprenoid binding|cellular carbohydrate metabolic process|cellular lipid metabolic process|enzyme inhibitor activity|cellular aromatic compound metabolic process|fatty acid binding|organic cyclic compound metabolic process|organic acid metabolic process|response to xenobiotic stimulus|steroid binding|anion binding|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|carbohydrate metabolic process|organic acid binding|protein dimerization activity|negative regulation of molecular function|flavonoid metabolic process|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular ketone metabolic process|xenobiotic metabolic process|drug metabolic process|regulation of catalytic activity|negative regulation of lipid metabolic process|negative regulation of catalytic activity|regulation of hormone levels|integral component of membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of carbohydrate metabolic process|retinoic acid metabolic process|protein heterodimerization activity|isoprenoid metabolic process|UDP-glycosyltransferase activity|fatty acid metabolic process|flavonoid glucuronidation|retinoid binding|xenobiotic glucuronidation|flavone metabolic process|transferase activity, transferring hexosyl groups|cellular response to xenobiotic stimulus|monosaccharide metabolic process|negative regulation of steroid metabolic process|regulation of cellular ketone metabolic process|steroid metabolic process|carboxylic acid binding|coumarin metabolic process|regulation of lipid metabolic process|negative regulation of fatty acid metabolic process|protein homodimerization activity|regulation of fatty acid metabolic process|regulation of steroid metabolic process|negative regulation of cellular glucuronidation|glucuronosyltransferase activity|negative regulation of glucuronosyltransferase activity|carboxylic acid metabolic process|retinoic acid binding|diterpenoid metabolic process|monocarboxylic acid metabolic process|cellular glucuronidation|retinoid metabolic process K00699 glucuronosyltransferase[2.4.1.17] hsa01100|hsa05204|hsa00980|hsa00982|hsa00830|hsa00140|hsa00500|hsa00983|hsa00860|hsa00040|hsa00053 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Ascorbate and aldarate metabolism - Homo sapiens (human) 2:233617645-233773310 0 0 0 0 294 256 0 0 0 0 7.08899355981932 7.05079614424922 0 4.71326323468951 -Inf 2.16364182191882e-08 3.74671478837381e-07 DOWN ENSG00000145194 ECE2 endothelin converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13275] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0042445|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0007507|GO:0007275|GO:0048513|GO:0034641|GO:0031982|GO:0007420|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0007267|GO:0016486|GO:0060322|GO:0012506|GO:0007154|GO:0010817|GO:0048869|GO:0016021|GO:0019538|GO:0005794|GO:0008168|GO:0006518|GO:0046872|GO:0072358|GO:0007417|GO:0031410|GO:0035051|GO:0051604|GO:0016023|GO:0006508|GO:0031988|GO:0043603|GO:0030659|GO:0010467|GO:0007399|GO:0000139|GO:0030154|GO:0072359|GO:0008237|GO:0048863|GO:0016485|GO:0004175|GO:0010002|GO:0004222 developmental process|signaling|cell|membrane|cellular process|metabolic process|binding|catalytic activity|methylation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|heart development|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|vesicle|brain development|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|cell-cell signaling|peptide hormone processing|head development|vesicle membrane|cell communication|regulation of hormone levels|cellular developmental process|integral component of membrane|protein metabolic process|Golgi apparatus|methyltransferase activity|peptide metabolic process|metal ion binding|cardiovascular system development|central nervous system development|cytoplasmic vesicle|cardiocyte differentiation|protein maturation|cytoplasmic, membrane-bounded vesicle|proteolysis|membrane-bounded vesicle|cellular amide metabolic process|cytoplasmic vesicle membrane|gene expression|nervous system development|Golgi membrane|cell differentiation|circulatory system development|metallopeptidase activity|stem cell differentiation|protein processing|endopeptidase activity|cardioblast differentiation|metalloendopeptidase activity - - - - 3:184249650-184293031 572 788 647 288 366 202 4.39273187633477 5.49977797064624 4.47978485441721 1.98165718908348 2.30615113698204 1.45385006712721 4.79076490046607 1.91388613106424 1.32375101961578 2.17210790427666e-08 3.7591947463348e-07 UP ENSG00000004700 RECQL RecQ helicase-like [Source:HGNC Symbol;Acc:HGNC:9948] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0006139|GO:0000166|GO:0044249|GO:0006996|GO:0051276|GO:0003677|GO:0034645|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0031981|GO:0005654|GO:0006259|GO:0017076|GO:0009059|GO:0005634|GO:0006974|GO:0006260|GO:0036310|GO:0005524|GO:0030554|GO:0006310|GO:0071103|GO:0016462|GO:0000733|GO:0032392|GO:0017111|GO:0016887|GO:0032508|GO:0004386|GO:0003678|GO:0042623|GO:0043138|GO:0008026|GO:0008094|GO:0004003|GO:0043140 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|organelle organization|chromosome organization|DNA binding|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|nucleoplasm|DNA metabolic process|purine nucleotide binding|macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|DNA replication|annealing helicase activity|ATP binding|adenyl nucleotide binding|DNA recombination|DNA conformation change|pyrophosphatase activity|DNA strand renaturation|DNA geometric change|nucleoside-triphosphatase activity|ATPase activity|DNA duplex unwinding|helicase activity|DNA helicase activity|ATPase activity, coupled|3'-5' DNA helicase activity|ATP-dependent helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity - - - - 12:21468911-21501669 310 331 470 872 966 861 3.69787494572759 3.58838573572173 5.05478641791071 9.31977133979942 9.45444203102518 9.62550075527087 4.11368236645334 9.46657137536516 -1.20241159965807 2.18396212971715e-08 3.77752059215387e-07 DOWN ENSG00000145919 BOD1 biorientation of chromosomes in cell division 1 [Source:HGNC Symbol;Acc:HGNC:25114] GO:0032991|GO:0005623|GO:0009987|GO:0043229|GO:0016043|GO:0005622|GO:0043234|GO:0007049|GO:0022402|GO:0000776|GO:0005737|GO:0051301|GO:0006996|GO:1903047|GO:0005815|GO:0000278|GO:0005694|GO:0007067|GO:0005856|GO:0000777|GO:0000793|GO:0015630|GO:0000775|GO:0000779 macromolecular complex|cell|cellular process|intracellular organelle|cellular component organization|intracellular|protein complex|cell cycle|cell cycle process|kinetochore|cytoplasm|cell division|organelle organization|mitotic cell cycle process|microtubule organizing center|mitotic cell cycle|chromosome|mitotic nuclear division|cytoskeleton|condensed chromosome kinetochore|condensed chromosome|microtubule cytoskeleton|chromosome, centromeric region|condensed chromosome, centromeric region - - - - 5:173607514-173616660 1844 1723 1769 902 1016 796 22.8159499884056 19.3750522311573 19.7342085759662 9.99958116232352 10.3142875765033 9.23037990120717 20.641736931843 9.84808288001133 1.06764956524742 2.1958263142036e-08 3.79584243105004e-07 UP ENSG00000147100 SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) [Source:HGNC Symbol;Acc:HGNC:10923] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0010817|GO:0016021|GO:0015349|GO:0006811|GO:0015075|GO:0009914|GO:0006820|GO:0015711|GO:0070327|GO:0015293|GO:0008509|GO:0046942|GO:0046943|GO:0015718|GO:0008514|GO:0008028 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|plasma membrane|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|regulation of hormone levels|integral component of membrane|thyroid hormone transmembrane transporter activity|ion transport|ion transmembrane transporter activity|hormone transport|anion transport|organic anion transport|thyroid hormone transport|symporter activity|anion transmembrane transporter activity|carboxylic acid transport|carboxylic acid transmembrane transporter activity|monocarboxylic acid transport|organic anion transmembrane transporter activity|monocarboxylic acid transmembrane transporter activity K08231 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 2[-] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) X:74421461-74533917 1 1 4 19 20 33 0.0129799511046614 0.0117970885430923 0.0467924079212865 0.220873833533352 0.212901955162628 0.401267730092866 0.0238564825230134 0.278347839596282 -3.54443563753321 2.22844028808851e-08 3.8499916875344e-07 DOWN ENSG00000272293 RP11-91J19.3 - - - - - - - 8:450714-451343 0 0 0 11 11 11 0 0 0 1.10659891995105 1.01334110584637 1.15748208873857 0 1.09247403817866 -Inf 2.23836101949226e-08 3.86489472966582e-07 DOWN ENSG00000267321 RP11-1094M14.11 - - - - - - - 17:35568120-35574792 270 219 240 82 112 53 14.7141166320033 10.8466483666981 11.7922434430576 4.00388101627451 5.00792886340422 2.70690878699651 12.4510028139197 3.90623955555841 1.6724096104832 2.29956608491663e-08 3.96828010977463e-07 UP ENSG00000261408 TEN1-CDK3 TEN1-CDK3 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:44420] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0043167|GO:0044237|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468 cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|ion binding|cellular metabolic process|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation - - - - 17:75979231-76005999 192 207 206 80 82 87 2.53907397560977 2.48784856141807 2.45614974192453 0.94789228900928 0.889727129314682 1.07825107783988 2.49435742631746 0.971956832054614 1.35970406412682 2.30175324789674e-08 3.9697597609884e-07 UP ENSG00000103089 FA2H fatty acid 2-hydroxylase [Source:HGNC Symbol;Acc:HGNC:21197] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0048856|GO:0031090|GO:0042127|GO:0044255|GO:0009888|GO:0048468|GO:0080132|GO:0006082|GO:0007275|GO:0048513|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0061024|GO:0006629|GO:0005783|GO:0048869|GO:0016021|GO:0042634|GO:0044249|GO:0010256|GO:0048732|GO:0055114|GO:0006665|GO:0046872|GO:0020037|GO:0007417|GO:0021782|GO:0006631|GO:0048733|GO:0006643|GO:0007009|GO:0043588|GO:0060429|GO:0008610|GO:0007399|GO:0030154|GO:0030258|GO:0008366|GO:0007422|GO:0042633|GO:0014044|GO:0043217|GO:0010001|GO:0001949|GO:0030855|GO:0014003|GO:0008544|GO:0006633|GO:0048709|GO:0046914|GO:0019752|GO:0042552|GO:0022008|GO:0030148|GO:0014037|GO:0022010|GO:0005506|GO:0032286|GO:0032287|GO:0022011|GO:0042063|GO:0032787|GO:0009913 developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of cell proliferation|cellular lipid metabolic process|tissue development|cell development|fatty acid alpha-hydroxylase activity|organic acid metabolic process|multicellular organism development|animal organ development|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|membrane organization|lipid metabolic process|endoplasmic reticulum|cellular developmental process|integral component of membrane|regulation of hair cycle|cellular biosynthetic process|endomembrane system organization|gland development|oxidation-reduction process|sphingolipid metabolic process|metal ion binding|heme binding|central nervous system development|glial cell development|fatty acid metabolic process|sebaceous gland development|membrane lipid metabolic process|plasma membrane organization|skin development|epithelium development|lipid biosynthetic process|nervous system development|cell differentiation|lipid modification|axon ensheathment|peripheral nervous system development|hair cycle|Schwann cell development|myelin maintenance|glial cell differentiation|sebaceous gland cell differentiation|epithelial cell differentiation|oligodendrocyte development|epidermis development|fatty acid biosynthetic process|oligodendrocyte differentiation|transition metal ion binding|carboxylic acid metabolic process|myelination|neurogenesis|sphingolipid biosynthetic process|Schwann cell differentiation|central nervous system myelination|iron ion binding|central nervous system myelin maintenance|peripheral nervous system myelin maintenance|myelination in peripheral nervous system|gliogenesis|monocarboxylic acid metabolic process|epidermal cell differentiation - - - - 16:74712955-74774831 40 38 100 222 229 293 0.598324178436117 0.516582253965879 1.34863009155506 2.97528028150412 2.81047263761309 4.1074627790094 0.821178841319019 3.2977385660422 -2.00570867092207 2.3141581177754e-08 3.98884967944959e-07 DOWN ENSG00000090339 ICAM1 intercellular adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:5344] GO:0040011|GO:0032502|GO:0004871|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0044406|GO:0051716|GO:0004872|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0045321|GO:0001909|GO:0019882|GO:0040012|GO:0006807|GO:0006950|GO:0044089|GO:0044702|GO:0071704|GO:0050900|GO:0006955|GO:0009628|GO:0009986|GO:0042698|GO:0051051|GO:0044237|GO:0038023|GO:0003006|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0005615|GO:0002684|GO:0050793|GO:0002682|GO:0022602|GO:0005515|GO:0005886|GO:0048856|GO:0048609|GO:0019222|GO:0016032|GO:0045137|GO:0051272|GO:1903409|GO:0002250|GO:0016337|GO:0002286|GO:0008360|GO:0045087|GO:0009897|GO:0006725|GO:0009888|GO:0002685|GO:0045123|GO:0048468|GO:0009314|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0048513|GO:0050877|GO:0070489|GO:0032535|GO:0005102|GO:0034641|GO:0005924|GO:0043062|GO:0006952|GO:0030155|GO:0001618|GO:0005912|GO:2001057|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0022607|GO:0098609|GO:0060009|GO:0005887|GO:0002437|GO:0048608|GO:0001541|GO:0002457|GO:0010243|GO:0004888|GO:0032970|GO:0001910|GO:0033627|GO:0031668|GO:0006928|GO:0032403|GO:0042592|GO:0072593|GO:0002687|GO:0022406|GO:0001775|GO:0009966|GO:0002263|GO:0007548|GO:1903524|GO:0050839|GO:0001772|GO:0019725|GO:0060008|GO:0060548|GO:0042493|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0009617|GO:0050776|GO:0046649|GO:0008406|GO:0007154|GO:0051270|GO:0060491|GO:0016477|GO:0007165|GO:0002366|GO:0009968|GO:0070062|GO:0009725|GO:0008219|GO:0001666|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0010035|GO:0009967|GO:0044249|GO:0019538|GO:0031334|GO:0043254|GO:0023014|GO:0010033|GO:0098857|GO:0031323|GO:0003013|GO:0043271|GO:0002443|GO:0006996|GO:0051090|GO:0007568|GO:0051701|GO:0019062|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0009743|GO:0098742|GO:0031344|GO:0035150|GO:1900027|GO:0010468|GO:0034645|GO:0034698|GO:0008584|GO:0007166|GO:0032956|GO:0002691|GO:0033993|GO:0043412|GO:0008585|GO:0046661|GO:0007010|GO:0061458|GO:0034097|GO:0051345|GO:0002237|GO:0022614|GO:0043069|GO:0002064|GO:2001234|GO:0048878|GO:0097368|GO:0051252|GO:0046545|GO:0071417|GO:0010628|GO:0010038|GO:0030334|GO:0043200|GO:0051926|GO:0036211|GO:2000377|GO:0071456|GO:0071219|GO:0005178|GO:0045907|GO:0006811|GO:0006954|GO:0055082|GO:0046209|GO:1903428|GO:0051091|GO:0007600|GO:0007569|GO:0043279|GO:0034341|GO:0030031|GO:0007159|GO:0051247|GO:0045428|GO:0046688|GO:0022604|GO:0010477|GO:0006461|GO:0030036|GO:0071453|GO:0043269|GO:0002460|GO:0032270|GO:0042110|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0010212|GO:0035556|GO:0032273|GO:0002693|GO:0033043|GO:0044267|GO:0014075|GO:0051174|GO:0010467|GO:0002438|GO:0019058|GO:0071310|GO:0030198|GO:0031328|GO:0006809|GO:0051246|GO:0031529|GO:0009059|GO:0030154|GO:0030832|GO:0045121|GO:0030335|GO:0031669|GO:1902531|GO:0016070|GO:0031667|GO:0008015|GO:0010557|GO:0032496|GO:0043067|GO:0097305|GO:1903426|GO:0005925|GO:0097190|GO:0046546|GO:0002291|GO:2000379|GO:0010638|GO:2001237|GO:0071322|GO:0003158|GO:0071312|GO:0045893|GO:0002456|GO:0001885|GO:0019221|GO:0031401|GO:0001678|GO:0070555|GO:0007157|GO:0034622|GO:0050954|GO:0071346|GO:0030855|GO:0030838|GO:0043408|GO:0046718|GO:0032774|GO:0006812|GO:2001141|GO:0043623|GO:0034284|GO:2001236|GO:0043087|GO:0016310|GO:0002526|GO:0051092|GO:0070371|GO:0019229|GO:0070486|GO:0008064|GO:0043547|GO:0045471|GO:0051493|GO:0043410|GO:0001975|GO:0042981|GO:0071345|GO:0045429|GO:0043066|GO:0097178|GO:0034612|GO:0030260|GO:0006464|GO:0007015|GO:0051495|GO:0046813|GO:0071396|GO:0097191|GO:0030833|GO:0006351|GO:0006915|GO:0006355|GO:0033500|GO:0071222|GO:0050880|GO:0036294|GO:0071333|GO:0042593|GO:0061028|GO:0051258|GO:0045446|GO:0007605|GO:0060333|GO:0071347|GO:0006468|GO:0071356|GO:1903506|GO:0042325|GO:0070374|GO:0001932|GO:0042310|GO:0018193|GO:1902042|GO:0030001|GO:0001934|GO:0051924|GO:0070372|GO:0071593|GO:0042327|GO:0008625|GO:1904036|GO:0008154|GO:1902041|GO:0072577|GO:0050731|GO:0050730|GO:2000351|GO:0009749|GO:2000352|GO:0030041|GO:0018108|GO:0006816 locomotion|developmental process|signal transducer activity|reproduction|immune system process|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|adhesion of symbiont to host|cellular response to stimulus|receptor activity|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|leukocyte activation|leukocyte mediated cytotoxicity|antigen processing and presentation|regulation of locomotion|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|single organism reproductive process|organic substance metabolic process|leukocyte migration|immune response|response to abiotic stimulus|cell surface|ovulation cycle|negative regulation of transport|cellular metabolic process|signaling receptor activity|developmental process involved in reproduction|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|extracellular space|positive regulation of immune system process|regulation of developmental process|regulation of immune system process|ovulation cycle process|protein binding|plasma membrane|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|viral process|development of primary sexual characteristics|positive regulation of cellular component movement|reactive oxygen species biosynthetic process|adaptive immune response|single organismal cell-cell adhesion|T cell activation involved in immune response|regulation of cell shape|innate immune response|external side of plasma membrane|cellular aromatic compound metabolic process|tissue development|regulation of leukocyte migration|cellular extravasation|cell development|response to radiation|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|animal organ development|neurological system process|T cell aggregation|regulation of cellular component size|receptor binding|cellular nitrogen compound metabolic process|cell-substrate adherens junction|extracellular structure organization|defense response|regulation of cell adhesion|virus receptor activity|adherens junction|reactive nitrogen species metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|cellular component assembly|cell-cell adhesion|Sertoli cell development|integral component of plasma membrane|inflammatory response to antigenic stimulus|reproductive structure development|ovarian follicle development|T cell antigen processing and presentation|response to organonitrogen compound|transmembrane signaling receptor activity|regulation of actin filament-based process|regulation of leukocyte mediated cytotoxicity|cell adhesion mediated by integrin|cellular response to extracellular stimulus|movement of cell or subcellular component|protein complex binding|homeostatic process|reactive oxygen species metabolic process|positive regulation of leukocyte migration|membrane docking|cell activation|regulation of signal transduction|cell activation involved in immune response|sex differentiation|positive regulation of blood circulation|cell adhesion molecule binding|immunological synapse|cellular homeostasis|Sertoli cell differentiation|negative regulation of cell death|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|response to bacterium|regulation of immune response|lymphocyte activation|gonad development|cell communication|regulation of cellular component movement|regulation of cell projection assembly|cell migration|signal transduction|leukocyte activation involved in immune response|negative regulation of signal transduction|extracellular exosome|response to hormone|cell death|response to hypoxia|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|regulation of cellular metabolic process|circulatory system process|negative regulation of ion transport|leukocyte mediated immunity|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|aging|interaction with host|virion attachment to host cell|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|response to carbohydrate|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of cell projection organization|regulation of tube size|regulation of ruffle assembly|regulation of gene expression|cellular macromolecule biosynthetic process|response to gonadotropin|male gonad development|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|regulation of cellular extravasation|response to lipid|macromolecule modification|female gonad development|male sex differentiation|cytoskeleton organization|reproductive system development|response to cytokine|positive regulation of hydrolase activity|response to molecule of bacterial origin|membrane to membrane docking|negative regulation of programmed cell death|epithelial cell development|negative regulation of apoptotic signaling pathway|chemical homeostasis|establishment of Sertoli cell barrier|regulation of RNA metabolic process|development of primary female sexual characteristics|cellular response to organonitrogen compound|positive regulation of gene expression|response to metal ion|regulation of cell migration|response to amino acid|negative regulation of calcium ion transport|protein modification process|regulation of reactive oxygen species metabolic process|cellular response to hypoxia|cellular response to molecule of bacterial origin|integrin binding|positive regulation of vasoconstriction|ion transport|inflammatory response|cellular chemical homeostasis|nitric oxide metabolic process|positive regulation of reactive oxygen species biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|sensory perception|cell aging|response to alkaloid|response to interferon-gamma|cell projection assembly|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|regulation of nitric oxide biosynthetic process|response to copper ion|regulation of cell morphogenesis|response to sulfur dioxide|protein complex assembly|actin cytoskeleton organization|cellular response to oxygen levels|regulation of ion transport|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|response to ionizing radiation|intracellular signal transduction|positive regulation of protein polymerization|positive regulation of cellular extravasation|regulation of organelle organization|cellular protein metabolic process|response to amine|regulation of phosphorus metabolic process|gene expression|acute inflammatory response to antigenic stimulus|viral life cycle|cellular response to organic substance|extracellular matrix organization|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|ruffle organization|macromolecule biosynthetic process|cell differentiation|regulation of actin filament length|membrane raft|positive regulation of cell migration|cellular response to nutrient levels|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|blood circulation|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|regulation of programmed cell death|response to alcohol|regulation of reactive oxygen species biosynthetic process|focal adhesion|apoptotic signaling pathway|development of primary male sexual characteristics|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|positive regulation of reactive oxygen species metabolic process|positive regulation of organelle organization|negative regulation of extrinsic apoptotic signaling pathway|cellular response to carbohydrate stimulus|endothelium development|cellular response to alkaloid|positive regulation of transcription, DNA-templated|T cell mediated immunity|endothelial cell development|cytokine-mediated signaling pathway|positive regulation of protein modification process|cellular glucose homeostasis|response to interleukin-1|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|cellular macromolecular complex assembly|sensory perception of mechanical stimulus|cellular response to interferon-gamma|epithelial cell differentiation|positive regulation of actin filament polymerization|regulation of MAPK cascade|viral entry into host cell|RNA biosynthetic process|cation transport|regulation of RNA biosynthetic process|cellular protein complex assembly|response to monosaccharide|regulation of extrinsic apoptotic signaling pathway|regulation of GTPase activity|phosphorylation|acute inflammatory response|positive regulation of NF-kappaB transcription factor activity|ERK1 and ERK2 cascade|regulation of vasoconstriction|leukocyte aggregation|regulation of actin polymerization or depolymerization|positive regulation of GTPase activity|response to ethanol|regulation of cytoskeleton organization|positive regulation of MAPK cascade|response to amphetamine|regulation of apoptotic process|cellular response to cytokine stimulus|positive regulation of nitric oxide biosynthetic process|negative regulation of apoptotic process|ruffle assembly|response to tumor necrosis factor|entry into host cell|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|receptor-mediated virion attachment to host cell|cellular response to lipid|extrinsic apoptotic signaling pathway|regulation of actin filament polymerization|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|carbohydrate homeostasis|cellular response to lipopolysaccharide|regulation of blood vessel size|cellular response to decreased oxygen levels|cellular response to glucose stimulus|glucose homeostasis|establishment of endothelial barrier|protein polymerization|endothelial cell differentiation|sensory perception of sound|interferon-gamma-mediated signaling pathway|cellular response to interleukin-1|protein phosphorylation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|vasoconstriction|peptidyl-amino acid modification|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|metal ion transport|positive regulation of protein phosphorylation|regulation of calcium ion transport|regulation of ERK1 and ERK2 cascade|lymphocyte aggregation|positive regulation of phosphorylation|extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of epithelial cell apoptotic process|actin polymerization or depolymerization|regulation of extrinsic apoptotic signaling pathway via death domain receptors|endothelial cell apoptotic process|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of endothelial cell apoptotic process|response to glucose|negative regulation of endothelial cell apoptotic process|actin filament polymerization|peptidyl-tyrosine phosphorylation|calcium ion transport K06490 intercellular adhesion molecule 1[-] hsa05166|hsa05169|hsa05164|hsa04514|hsa04650|hsa04670|hsa04668|hsa04933|hsa04064|hsa05323|hsa05416|hsa05150|hsa05144|hsa05143 HTLV-I infection - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Cell adhesion molecules (CAMs) - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|Viral myocarditis - Homo sapiens (human)|Staphylococcus aureus infection - Homo sapiens (human)|Malaria - Homo sapiens (human)|African trypanosomiasis - Homo sapiens (human) 19:10270835-10286615 1881 1812 2085 947 1008 1058 24.2140177077744 21.1990489381658 24.1990538440273 10.9225928471325 10.6464878286153 12.7641734674115 23.2040401633225 11.4444180477198 1.01973191830595 2.32800114434888e-08 4.01039504693546e-07 UP ENSG00000166689 PLEKHA7 pleckstrin homology domain containing A7 [Source:HGNC Symbol;Acc:HGNC:27049] GO:0005623|GO:0009987|GO:0005576|GO:0030054|GO:0005488|GO:1903561|GO:0043229|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0005622|GO:0005515|GO:0016337|GO:0005912|GO:0031982|GO:0098609|GO:0043231|GO:0005737|GO:0070097|GO:0005913|GO:0070062|GO:0043954|GO:0043296|GO:0005813|GO:0045216|GO:0005815|GO:0090136|GO:0005915|GO:0005856|GO:0005634|GO:0015630|GO:0045217|GO:0045218 cell|cellular process|extracellular region|cell junction|binding|extracellular vesicle|intracellular organelle|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|intracellular|protein binding|single organismal cell-cell adhesion|adherens junction|vesicle|cell-cell adhesion|intracellular membrane-bounded organelle|cytoplasm|delta-catenin binding|cell-cell adherens junction|extracellular exosome|cellular component maintenance|apical junction complex|centrosome|cell-cell junction organization|microtubule organizing center|epithelial cell-cell adhesion|zonula adherens|cytoskeleton|nucleus|microtubule cytoskeleton|cell-cell junction maintenance|zonula adherens maintenance - - - - 11:16778295-17014443 162 189 356 668 692 719 0.68113214961923 0.722202241892654 1.3495236433456 2.51646451145391 2.38721073028945 2.83318145805774 0.917619344952495 2.57895223326703 -1.49081734090958 2.35150438168958e-08 4.04854739394236e-07 DOWN ENSG00000160161 CILP2 cartilage intermediate layer protein 2 [Source:HGNC Symbol;Acc:HGNC:24213] GO:0031012|GO:0005576|GO:0005488|GO:1903561|GO:0005578|GO:0043227|GO:0005515|GO:0031982|GO:0070062 extracellular matrix|extracellular region|binding|extracellular vesicle|proteinaceous extracellular matrix|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 19:19538248-19546659 117 125 35 16 15 8 1.73069663324012 1.68045654214587 0.466791812151423 0.212051343265853 0.182057650705079 0.110906833913038 1.29264832917914 0.168338609294657 2.94089182782876 2.35831315848739e-08 4.05792974256384e-07 UP ENSG00000109519 GRPEL1 GrpE-like 1, mitochondrial (E. coli) [Source:HGNC Symbol;Acc:HGNC:19696] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0006457|GO:0043227|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0006810|GO:0043231|GO:0051087|GO:0005737|GO:0046983|GO:0045184|GO:0008104|GO:0051649|GO:0051082|GO:0050790|GO:0000166|GO:0019538|GO:0006996|GO:0072594|GO:0007005|GO:0015031|GO:0046907|GO:0005759|GO:0005739|GO:0034613|GO:0044267|GO:0017076|GO:0006626|GO:0060590|GO:0005634|GO:0042803|GO:0033365|GO:0006839|GO:0030554|GO:0006605|GO:0072655|GO:0006886|GO:0000774|GO:0070585 cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|protein folding|membrane-bounded organelle|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|identical protein binding|transport|intracellular membrane-bounded organelle|chaperone binding|cytoplasm|protein dimerization activity|establishment of protein localization|protein localization|establishment of localization in cell|unfolded protein binding|regulation of catalytic activity|nucleotide binding|protein metabolic process|organelle organization|establishment of protein localization to organelle|mitochondrion organization|protein transport|intracellular transport|mitochondrial matrix|mitochondrion|cellular protein localization|cellular protein metabolic process|purine nucleotide binding|protein targeting to mitochondrion|ATPase regulator activity|nucleus|protein homodimerization activity|protein localization to organelle|mitochondrial transport|adenyl nucleotide binding|protein targeting|establishment of protein localization to mitochondrion|intracellular protein transport|adenyl-nucleotide exchange factor activity|protein localization to mitochondrion - - - - 4:7058906-7068197 1522 1549 1254 650 818 507 18.600815245201 17.2047655569744 13.8174858336062 7.11750925946399 8.20235026396456 5.8070324657096 16.5410222119272 7.04229732971272 1.2319303488031 2.36547557421816e-08 4.06790943506388e-07 UP ENSG00000148175 STOM stomatin [Source:HGNC Symbol;Acc:HGNC:3383] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0009056|GO:0051641|GO:0006914|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0005615|GO:0005622|GO:0002682|GO:0072562|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0042802|GO:0016032|GO:0060341|GO:0006810|GO:0051130|GO:0050688|GO:0051702|GO:0006952|GO:0031982|GO:0048524|GO:0051128|GO:0033554|GO:0022607|GO:0098542|GO:0005887|GO:0043231|GO:0019899|GO:0005737|GO:0032880|GO:0051222|GO:0009615|GO:0009966|GO:0046983|GO:0045184|GO:0032388|GO:0010646|GO:0031226|GO:0008104|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0000422|GO:0005783|GO:0070062|GO:0051649|GO:0090316|GO:0016236|GO:0051607|GO:0016021|GO:0010469|GO:0050792|GO:0098857|GO:0006996|GO:0090150|GO:1903008|GO:0098792|GO:0000423|GO:0031410|GO:0007005|GO:0032386|GO:0051223|GO:0015031|GO:0044794|GO:0016023|GO:0070201|GO:0046907|GO:0006811|GO:0070063|GO:0072657|GO:0048471|GO:0031988|GO:0034765|GO:0005739|GO:0006461|GO:0043269|GO:0034613|GO:1901585|GO:1903902|GO:0019079|GO:0019058|GO:0045121|GO:1903827|GO:0090314|GO:0005856|GO:0042803|GO:0022898|GO:0050691|GO:0034220|GO:0044829|GO:0098655|GO:0033157|GO:0051259|GO:0006812|GO:0006605|GO:0045069|GO:0006886|GO:0032412|GO:0002230|GO:0045070|GO:0098779|GO:0006612|GO:1903533|GO:0042470|GO:0002028|GO:1902305|GO:0030001|GO:2000649|GO:2001257|GO:0051260|GO:0015672|GO:0035725|GO:0006814 immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|catabolic process|cellular localization|autophagy|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|extracellular space|intracellular|regulation of immune system process|blood microparticle|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|identical protein binding|viral process|regulation of cellular localization|transport|positive regulation of cellular component organization|regulation of defense response to virus|interaction with symbiont|defense response|vesicle|positive regulation of viral process|regulation of cellular component organization|cellular response to stress|cellular component assembly|defense response to other organism|integral component of plasma membrane|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of protein localization|positive regulation of protein transport|response to virus|regulation of signal transduction|protein dimerization activity|establishment of protein localization|positive regulation of intracellular transport|regulation of cell communication|intrinsic component of plasma membrane|protein localization|cell communication|transmembrane transport|membrane organization|signal transduction|mitophagy|endoplasmic reticulum|extracellular exosome|establishment of localization in cell|positive regulation of intracellular protein transport|macroautophagy|defense response to virus|integral component of membrane|regulation of receptor activity|regulation of viral process|membrane microdomain|organelle organization|establishment of protein localization to membrane|organelle disassembly|xenophagy|macromitophagy|cytoplasmic vesicle|mitochondrion organization|regulation of intracellular transport|regulation of protein transport|protein transport|positive regulation by host of viral process|cytoplasmic, membrane-bounded vesicle|regulation of establishment of protein localization|intracellular transport|ion transport|RNA polymerase binding|protein localization to membrane|perinuclear region of cytoplasm|membrane-bounded vesicle|regulation of ion transmembrane transport|mitochondrion|protein complex assembly|regulation of ion transport|cellular protein localization|regulation of acid-sensing ion channel activity|positive regulation of viral life cycle|viral genome replication|viral life cycle|membrane raft|regulation of cellular protein localization|positive regulation of protein targeting to membrane|cytoskeleton|protein homodimerization activity|regulation of transmembrane transporter activity|regulation of defense response to virus by host|ion transmembrane transport|positive regulation by host of viral genome replication|cation transmembrane transport|regulation of intracellular protein transport|protein oligomerization|cation transport|protein targeting|regulation of viral genome replication|intracellular protein transport|regulation of ion transmembrane transporter activity|positive regulation of defense response to virus by host|positive regulation of viral genome replication|mitophagy in response to mitochondrial depolarization|protein targeting to membrane|regulation of protein targeting|melanosome|regulation of sodium ion transport|regulation of sodium ion transmembrane transport|metal ion transport|regulation of sodium ion transmembrane transporter activity|regulation of cation channel activity|protein homooligomerization|monovalent inorganic cation transport|sodium ion transmembrane transport|sodium ion transport - - - - 9:121338988-121370304 669 761 1294 376 409 435 9.91472309954127 10.2498906675352 17.2903128716588 4.99274398563027 4.97331462907771 6.04188049310242 12.4849755462451 5.33597970260347 1.22636791171274 2.37206264421721e-08 4.07688878413704e-07 UP ENSG00000134243 SORT1 sortilin 1 [Source:HGNC Symbol;Acc:HGNC:11186] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0009986|GO:0051641|GO:0038023|GO:0044297|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005905|GO:0050793|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0045595|GO:0043025|GO:0019838|GO:0006810|GO:0010941|GO:0007275|GO:0045596|GO:0031982|GO:0010942|GO:0061061|GO:0043231|GO:0030133|GO:0019899|GO:0010243|GO:0004888|GO:0005774|GO:0005737|GO:0005635|GO:1990089|GO:0043005|GO:0036477|GO:0007154|GO:0044092|GO:0007165|GO:0005783|GO:0001503|GO:0005030|GO:0051649|GO:0009725|GO:0008219|GO:0031965|GO:0010008|GO:0050790|GO:0043086|GO:0048869|GO:0016021|GO:0010033|GO:0005794|GO:0005768|GO:0006996|GO:0016192|GO:0043121|GO:0007186|GO:0005798|GO:0010468|GO:0016050|GO:0007166|GO:1990090|GO:0031410|GO:0005769|GO:0042692|GO:0030379|GO:1901652|GO:0005773|GO:0016023|GO:0045599|GO:0046907|GO:0043434|GO:0030425|GO:0048471|GO:0051346|GO:0070848|GO:0031988|GO:0012501|GO:0005795|GO:0010467|GO:0030140|GO:0071310|GO:0000139|GO:0045598|GO:0010465|GO:0030154|GO:0043068|GO:0008643|GO:0005634|GO:0043067|GO:0097190|GO:0045444|GO:0038180|GO:0048406|GO:0048227|GO:0043065|GO:0000323|GO:0071363|GO:0038179|GO:0048193|GO:0031985|GO:0016482|GO:0007167|GO:0030135|GO:0016197|GO:0032580|GO:0051146|GO:0042981|GO:0060192|GO:0007218|GO:0032868|GO:0006897|GO:0007034|GO:0097191|GO:0005765|GO:0006915|GO:0048011|GO:0032509|GO:0030136|GO:0051005|GO:0008645|GO:0008333|GO:0007041|GO:0005764|GO:1904037|GO:0014902|GO:0006892|GO:0006895|GO:0008625|GO:0007169|GO:0015758|GO:0046323 developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cell surface|cellular localization|signaling receptor activity|cell body|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|coated pit|regulation of developmental process|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cell differentiation|neuronal cell body|growth factor binding|transport|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|vesicle|positive regulation of cell death|muscle structure development|intracellular membrane-bounded organelle|transport vesicle|enzyme binding|response to organonitrogen compound|transmembrane signaling receptor activity|vacuolar membrane|cytoplasm|nuclear envelope|response to nerve growth factor|neuron projection|somatodendritic compartment|cell communication|negative regulation of molecular function|signal transduction|endoplasmic reticulum|ossification|neurotrophin receptor activity|establishment of localization in cell|response to hormone|cell death|nuclear membrane|endosome membrane|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|response to organic substance|Golgi apparatus|endosome|organelle organization|vesicle-mediated transport|neurotrophin binding|G-protein coupled receptor signaling pathway|Golgi-associated vesicle|regulation of gene expression|vesicle organization|cell surface receptor signaling pathway|cellular response to nerve growth factor stimulus|cytoplasmic vesicle|early endosome|muscle cell differentiation|neurotensin receptor activity, non-G-protein coupled|response to peptide|vacuole|cytoplasmic, membrane-bounded vesicle|negative regulation of fat cell differentiation|intracellular transport|response to peptide hormone|dendrite|perinuclear region of cytoplasm|negative regulation of hydrolase activity|response to growth factor|membrane-bounded vesicle|programmed cell death|Golgi stack|gene expression|trans-Golgi network transport vesicle|cellular response to organic substance|Golgi membrane|regulation of fat cell differentiation|nerve growth factor receptor activity|cell differentiation|positive regulation of programmed cell death|carbohydrate transport|nucleus|regulation of programmed cell death|apoptotic signaling pathway|fat cell differentiation|nerve growth factor signaling pathway|nerve growth factor binding|plasma membrane to endosome transport|positive regulation of apoptotic process|lytic vacuole|cellular response to growth factor stimulus|neurotrophin signaling pathway|Golgi vesicle transport|Golgi cisterna|cytosolic transport|enzyme linked receptor protein signaling pathway|coated vesicle|endosomal transport|Golgi cisterna membrane|striated muscle cell differentiation|regulation of apoptotic process|negative regulation of lipase activity|neuropeptide signaling pathway|response to insulin|endocytosis|vacuolar transport|extrinsic apoptotic signaling pathway|lysosomal membrane|apoptotic process|neurotrophin TRK receptor signaling pathway|endosome transport via multivesicular body sorting pathway|clathrin-coated vesicle|negative regulation of lipoprotein lipase activity|hexose transport|endosome to lysosome transport|lysosomal transport|lysosome|positive regulation of epithelial cell apoptotic process|myotube differentiation|post-Golgi vesicle-mediated transport|Golgi to endosome transport|extrinsic apoptotic signaling pathway via death domain receptors|transmembrane receptor protein tyrosine kinase signaling pathway|glucose transport|glucose import K12388 sortilin[-] hsa04142|hsa04722 Lysosome - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human) 1:109309568-109397951 437 442 734 1243 1384 1545 2.08526656899281 1.91682733191207 3.15784462326096 5.31433748546247 5.41856506553094 6.90935716791336 2.38664617472195 5.88075323963559 -1.30101625559422 2.3840749215619e-08 4.09517679564493e-07 DOWN ENSG00000101337 TM9SF4 transmembrane 9 superfamily protein member 4 [Source:HGNC Symbol;Acc:HGNC:30797] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 20:32109506-32167258 550 559 860 1505 1617 1788 5.93882592995131 5.48567123902575 8.37241993615404 14.5603640976306 14.3257103379166 18.0939996595474 6.59897236837703 15.6600246983649 -1.24677320605596 2.39933381210701e-08 4.11901734483282e-07 DOWN ENSG00000141424 SLC39A6 solute carrier family 39 (zinc transporter), member 6 [Source:HGNC Symbol;Acc:HGNC:18607] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0042995|GO:0022857|GO:0043229|GO:0009986|GO:0043227|GO:0071944|GO:0031252|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0006810|GO:0005887|GO:0043231|GO:0005737|GO:0042592|GO:0030027|GO:0019725|GO:0022891|GO:0031226|GO:0055085|GO:0005783|GO:0031256|GO:0031253|GO:0016021|GO:0031258|GO:0048878|GO:0006811|GO:0055082|GO:0015075|GO:0034220|GO:0098655|GO:0006812|GO:0050801|GO:0006873|GO:0008324|GO:0022890|GO:0030001|GO:0030003|GO:0055065|GO:0006875|GO:0071577|GO:0046873|GO:0006882|GO:0046915|GO:0055069|GO:0071578|GO:0006829|GO:0005385 transporter activity|cell|membrane|cellular process|cell projection|transmembrane transporter activity|intracellular organelle|cell surface|membrane-bounded organelle|cell periphery|cell leading edge|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|transport|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|lamellipodium|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|endoplasmic reticulum|leading edge membrane|cell projection membrane|integral component of membrane|lamellipodium membrane|chemical homeostasis|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|cation transport|ion homeostasis|cellular ion homeostasis|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|zinc II ion transmembrane transport|metal ion transmembrane transporter activity|cellular zinc ion homeostasis|transition metal ion transmembrane transporter activity|zinc ion homeostasis|zinc II ion transmembrane import|zinc II ion transport|zinc ion transmembrane transporter activity - - - - 18:36108532-36129385 2553 2759 2359 1246 1491 1030 34.7157186114381 34.0962859301726 28.9212840987223 15.1806707772415 16.6349289313544 13.1262823495961 32.577762880111 14.9806273527307 1.12078949551025 2.42775930136011e-08 4.16542104498877e-07 UP ENSG00000178074 C2orf69 chromosome 2 open reading frame 69 [Source:HGNC Symbol;Acc:HGNC:26799] GO:0005576 extracellular region - - - - 2:199911256-199955935 1063 1226 1366 571 712 623 15.7902679785209 16.5511033279233 18.2945295219411 7.59958348033762 8.67769315118363 8.67308643633937 16.8786336094618 8.31678768928687 1.02109980851581 2.43410904627401e-08 4.17391679882047e-07 UP ENSG00000169116 PARM1 prostate androgen-regulated mucin-like protein 1 [Source:HGNC Symbol;Acc:HGNC:24536] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0043085|GO:0010008|GO:0050790|GO:0016021|GO:0044249|GO:0031323|GO:0005794|GO:0005768|GO:0034645|GO:0005769|GO:0051347|GO:0005770|GO:0006259|GO:0051054|GO:0000139|GO:0031328|GO:0009059|GO:0010557|GO:0005634|GO:0006260|GO:0051972|GO:0051973|GO:2000278|GO:0006275|GO:2000573|GO:0045740|GO:0071897 cell|membrane|cellular process|metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|endosome membrane|regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|regulation of cellular metabolic process|Golgi apparatus|endosome|cellular macromolecule biosynthetic process|early endosome|positive regulation of transferase activity|late endosome|DNA metabolic process|positive regulation of DNA metabolic process|Golgi membrane|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|positive regulation of macromolecule biosynthetic process|nucleus|DNA replication|regulation of telomerase activity|positive regulation of telomerase activity|regulation of DNA biosynthetic process|regulation of DNA replication|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|DNA biosynthetic process - - - - 4:74933095-75050115 269 267 430 818 871 767 2.05933148873014 1.8576558527889 2.96794676695841 5.61080154119757 5.4709109955381 5.50298525205588 2.29497803615915 5.52823259626385 -1.26833797077395 2.47787995517544e-08 4.24653433879493e-07 DOWN ENSG00000135749 PCNXL2 pecanex-like 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:8736] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 1:232983435-233295713 121 140 313 604 647 655 0.437072553382822 0.459593641988956 1.01935503560835 1.95479510852715 1.91751480318254 2.21736164082042 0.638673743660043 2.02989051751004 -1.66825087090105 2.48365216603632e-08 4.25398461071993e-07 DOWN ENSG00000141644 MBD1 methyl-CpG binding domain protein 1 [Source:HGNC Symbol;Acc:HGNC:6916] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0032259|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009605|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0007507|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0009991|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0009890|GO:0003682|GO:0042493|GO:0016458|GO:0006139|GO:0000790|GO:0009725|GO:0000166|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0007568|GO:0050768|GO:0006346|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0043412|GO:0072358|GO:0007417|GO:0010629|GO:0008327|GO:0051252|GO:0006325|GO:0010721|GO:0045472|GO:0006306|GO:0043279|GO:0031981|GO:0036276|GO:0005654|GO:0006259|GO:0016363|GO:0005694|GO:0000228|GO:0006342|GO:0014070|GO:0060359|GO:0010467|GO:0007399|GO:0009059|GO:0030154|GO:0034399|GO:0016070|GO:0072359|GO:0031667|GO:0005634|GO:0042220|GO:0048545|GO:0097305|GO:0051960|GO:0030182|GO:0044030|GO:0045814|GO:0014076|GO:0010001|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0043627|GO:1902679|GO:0016604|GO:0006304|GO:0003690|GO:0040029|GO:0032355|GO:0046914|GO:0016568|GO:0022008|GO:0050767|GO:0048708|GO:0006351|GO:0006355|GO:0016607|GO:0045686|GO:0048710|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:0014013|GO:1903506|GO:0045685|GO:0042063|GO:0000122|GO:0008270|GO:0010385|GO:0048712 developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|small molecule binding|methylation|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|response to external stimulus|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|heart development|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|response to extracellular stimulus|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|negative regulation of biosynthetic process|chromatin binding|response to drug|gene silencing|nucleobase-containing compound metabolic process|nuclear chromatin|response to hormone|nucleotide binding|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|aging|negative regulation of neurogenesis|methylation-dependent chromatin silencing|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|macromolecule modification|cardiovascular system development|central nervous system development|negative regulation of gene expression|methyl-CpG binding|regulation of RNA metabolic process|chromatin organization|negative regulation of cell development|response to ether|DNA methylation|response to alkaloid|nuclear lumen|response to antidepressant|nucleoplasm|DNA metabolic process|nuclear matrix|chromosome|nuclear chromosome|chromatin silencing|response to organic cyclic compound|response to ammonium ion|gene expression|nervous system development|macromolecule biosynthetic process|cell differentiation|nuclear periphery|RNA metabolic process|circulatory system development|response to nutrient levels|nucleus|response to cocaine|response to steroid hormone|response to alcohol|regulation of nervous system development|neuron differentiation|regulation of DNA methylation|negative regulation of gene expression, epigenetic|response to fluoxetine|glial cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|response to estrogen|negative regulation of RNA biosynthetic process|nuclear body|DNA modification|double-stranded DNA binding|regulation of gene expression, epigenetic|response to estradiol|transition metal ion binding|chromatin modification|neurogenesis|regulation of neurogenesis|astrocyte differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|negative regulation of glial cell differentiation|regulation of astrocyte differentiation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of gliogenesis|regulation of nucleic acid-templated transcription|regulation of glial cell differentiation|gliogenesis|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|double-stranded methylated DNA binding|negative regulation of astrocyte differentiation - - - - 18:50266882-50281774 1321 1324 1174 624 715 560 5.2083705895256 4.74424556330859 4.17331795005202 2.20435346659673 2.31298736677669 2.06926433961589 4.70864470096207 2.1955350576631 1.10073929447993 2.49735900000504e-08 4.27500892122422e-07 UP ENSG00000163684 RPP14 ribonuclease P/MRP 14kDa subunit [Source:HGNC Symbol;Acc:HGNC:30327] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0006139|GO:0003723|GO:0031981|GO:0004518|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0090501|GO:0006396|GO:0034660|GO:0004519|GO:0004540|GO:0090305|GO:0006399|GO:0090502|GO:0004521|GO:0008033|GO:0004526|GO:0016891 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|RNA binding|nuclear lumen|nuclease activity|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA phosphodiester bond hydrolysis|RNA processing|ncRNA metabolic process|endonuclease activity|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|tRNA metabolic process|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|tRNA processing|ribonuclease P activity|endoribonuclease activity, producing 5'-phosphomonoesters K14529 ribonuclease P protein subunit RPP14[3.1.26.5] hsa03013 RNA transport - Homo sapiens (human) 3:58306247-58324695 545 781 502 279 260 242 2.99081566973194 3.89514927833413 2.48376890008575 1.37181138512742 1.17066947873166 1.24462337992005 3.12324461605061 1.26236808125971 1.30691293463933 2.64505171899665e-08 4.52523633346281e-07 UP ENSG00000166813 KIF7 kinesin family member 7 [Source:HGNC Symbol;Acc:HGNC:30497] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0043167|GO:0023051|GO:0023057|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0005929|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0006928|GO:0032403|GO:0009966|GO:0010646|GO:0005875|GO:0007154|GO:0007165|GO:0009968|GO:0008092|GO:0097542|GO:0000166|GO:0009967|GO:0007017|GO:0015631|GO:0005871|GO:0007166|GO:0035639|GO:0001883|GO:0045880|GO:0008589|GO:0008017|GO:0045879|GO:0016818|GO:0032549|GO:0007018|GO:0017076|GO:0005856|GO:0005524|GO:0007224|GO:0030554|GO:0015630|GO:0016462|GO:0017111|GO:0016887|GO:0003774|GO:0003777 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|ion binding|regulation of signaling|negative regulation of signaling|hydrolase activity|intracellular|protein binding|protein complex|cilium|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|movement of cell or subcellular component|protein complex binding|regulation of signal transduction|regulation of cell communication|microtubule associated complex|cell communication|signal transduction|negative regulation of signal transduction|cytoskeletal protein binding|ciliary tip|nucleotide binding|positive regulation of signal transduction|microtubule-based process|tubulin binding|kinesin complex|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|purine nucleoside binding|positive regulation of smoothened signaling pathway|regulation of smoothened signaling pathway|microtubule binding|negative regulation of smoothened signaling pathway|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|microtubule-based movement|purine nucleotide binding|cytoskeleton|ATP binding|smoothened signaling pathway|adenyl nucleotide binding|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|motor activity|microtubule motor activity - - - - 15:89608789-89655451 9 11 14 50 70 46 0.11259907976794 0.125077953223848 0.15792230773859 0.560473009182463 0.718550104428135 0.539352117284585 0.131866446910126 0.606125076965061 -2.20053801069889 2.65539914649095e-08 4.54033712023716e-07 DOWN ENSG00000186141 POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) [Source:HGNC Symbol;Acc:HGNC:30076] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0045087|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0006952|GO:0016772|GO:0046483|GO:0098542|GO:0001817|GO:0043231|GO:0005737|GO:0001816|GO:0009615|GO:0001819|GO:0006139|GO:0050776|GO:0050778|GO:0051607|GO:0044249|GO:0031323|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0032479|GO:0051252|GO:0032481|GO:0031981|GO:1990234|GO:0032606|GO:0005654|GO:0010467|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0045089|GO:0045088|GO:0032774|GO:0032728|GO:2001141|GO:0032608|GO:0032648|GO:0006351|GO:0006355|GO:0005666|GO:0003899|GO:0006383|GO:1903506|GO:0006354|GO:0006359|GO:0006353|GO:0001056|GO:0006385|GO:0006386 macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|transferase activity|regulation of metabolic process|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|defense response to other organism|regulation of cytokine production|intracellular membrane-bounded organelle|cytoplasm|cytokine production|response to virus|positive regulation of cytokine production|nucleobase-containing compound metabolic process|regulation of immune response|positive regulation of immune response|defense response to virus|cellular biosynthetic process|regulation of cellular metabolic process|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of type I interferon production|regulation of RNA metabolic process|positive regulation of type I interferon production|nuclear lumen|transferase complex|type I interferon production|nucleoplasm|gene expression|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|positive regulation of innate immune response|regulation of innate immune response|RNA biosynthetic process|positive regulation of interferon-beta production|regulation of RNA biosynthetic process|interferon-beta production|regulation of interferon-beta production|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase activity|transcription from RNA polymerase III promoter|regulation of nucleic acid-templated transcription|DNA-templated transcription, elongation|regulation of transcription from RNA polymerase III promoter|DNA-templated transcription, termination|RNA polymerase III activity|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription K03023 DNA-directed RNA polymerase III subunit RPC3[-] hsa01100|hsa05169|hsa00230|hsa00240|hsa04623|hsa03020 Metabolic pathways - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Cytosolic DNA-sensing pathway - Homo sapiens (human)|RNA polymerase - Homo sapiens (human) 1:145824088-145842505 837 996 692 392 438 294 15.7758438627747 17.061074798846 11.759466362833 6.61989360115178 6.77343691633306 5.19330594919083 14.8654616748179 6.19554548889189 1.26266105390196 2.67420310626617e-08 4.56987175354723e-07 UP ENSG00000164603 C7orf60 chromosome 7 open reading frame 60 [Source:HGNC Symbol;Acc:HGNC:26475] GO:0009987|GO:0008152|GO:0003824|GO:0032259|GO:0006807|GO:0071704|GO:0044237|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0006139|GO:0022613|GO:0008168|GO:0043412|GO:0042254|GO:0001510|GO:0010467|GO:0016070|GO:0006364|GO:0006396|GO:0034660|GO:0031167|GO:0009451|GO:0008173|GO:0008757|GO:0008649|GO:0016072|GO:0000154|GO:0016433 cellular process|metabolic process|catalytic activity|methylation|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|methyltransferase activity|macromolecule modification|ribosome biogenesis|RNA methylation|gene expression|RNA metabolic process|rRNA processing|RNA processing|ncRNA metabolic process|rRNA methylation|RNA modification|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|rRNA methyltransferase activity|rRNA metabolic process|rRNA modification|rRNA (adenine) methyltransferase activity - - - - 7:112819147-112939916 53 52 82 210 180 312 0.761381902645206 0.678907333085218 1.06207692262856 2.70299151501847 2.12161809503791 4.200601477988 0.834122052786328 3.00840369601479 -1.85066776808125 2.70815596392154e-08 4.62524531732916e-07 DOWN ENSG00000133641 C12orf29 chromosome 12 open reading frame 29 [Source:HGNC Symbol;Acc:HGNC:25322] GO:0032502|GO:0002376|GO:0009987|GO:0002520|GO:0048856|GO:0007275|GO:0048513|GO:0048869|GO:0030097|GO:0030154|GO:0002244 developmental process|immune system process|cellular process|immune system development|anatomical structure development|multicellular organism development|animal organ development|cellular developmental process|hemopoiesis|cell differentiation|hematopoietic progenitor cell differentiation - - - - 12:88033846-88050160 975 931 715 401 459 324 5.87365334103922 5.09722104493164 3.88350699041558 2.1644401549547 2.26873730489942 1.82926768343518 4.95146045879548 2.08748171442977 1.24609055813726 2.72451708049333e-08 4.65052789714396e-07 UP ENSG00000156232 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules [Source:HGNC Symbol;Acc:HGNC:30493] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0044877|GO:0050794|GO:0043229|GO:0044089|GO:0051641|GO:0016043|GO:0007155|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0006810|GO:0051130|GO:0032535|GO:0005874|GO:0031982|GO:0051128|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0032970|GO:0012506|GO:0032403|GO:0031589|GO:0061024|GO:0051649|GO:0008092|GO:0030030|GO:0030029|GO:0031334|GO:0043254|GO:0010256|GO:0005794|GO:0006996|GO:0016192|GO:0015631|GO:0045216|GO:0032956|GO:0005793|GO:0007010|GO:0031410|GO:0071933|GO:0003779|GO:0033116|GO:0008017|GO:0007009|GO:0016023|GO:0007160|GO:0046907|GO:0034329|GO:0030031|GO:0031988|GO:0006461|GO:0030036|GO:0097581|GO:0030659|GO:0032273|GO:0033043|GO:0000139|GO:0051020|GO:0030832|GO:0005856|GO:0010638|GO:0030032|GO:0031532|GO:0034622|GO:0030838|GO:0034332|GO:0043623|GO:0048193|GO:0008064|GO:0051493|GO:0007044|GO:0015630|GO:0031267|GO:0097320|GO:0048041|GO:0007015|GO:0051495|GO:0030833|GO:0034333|GO:0051125|GO:0051258|GO:0017016|GO:0090527|GO:0045010|GO:0006888|GO:0008154|GO:0051127|GO:0017048|GO:0030041|GO:0017049 cell|membrane|cellular process|binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|cellular localization|cellular component organization|cell adhesion|membrane-bounded organelle|intracellular|protein binding|endomembrane system|organelle membrane|transport|positive regulation of cellular component organization|regulation of cellular component size|microtubule|vesicle|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of actin filament-based process|vesicle membrane|protein complex binding|cell-substrate adhesion|membrane organization|establishment of localization in cell|cytoskeletal protein binding|cell projection organization|actin filament-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|endomembrane system organization|Golgi apparatus|organelle organization|vesicle-mediated transport|tubulin binding|cell-cell junction organization|regulation of actin cytoskeleton organization|endoplasmic reticulum-Golgi intermediate compartment|cytoskeleton organization|cytoplasmic vesicle|Arp2/3 complex binding|actin binding|endoplasmic reticulum-Golgi intermediate compartment membrane|microtubule binding|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|cell-matrix adhesion|intracellular transport|cell junction assembly|cell projection assembly|membrane-bounded vesicle|protein complex assembly|actin cytoskeleton organization|lamellipodium organization|cytoplasmic vesicle membrane|positive regulation of protein polymerization|regulation of organelle organization|Golgi membrane|GTPase binding|regulation of actin filament length|cytoskeleton|positive regulation of organelle organization|lamellipodium assembly|actin cytoskeleton reorganization|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|adherens junction organization|cellular protein complex assembly|Golgi vesicle transport|regulation of actin polymerization or depolymerization|regulation of cytoskeleton organization|cell-substrate junction assembly|microtubule cytoskeleton|small GTPase binding|membrane tubulation|focal adhesion assembly|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|adherens junction assembly|regulation of actin nucleation|protein polymerization|Ras GTPase binding|actin filament reorganization|actin nucleation|ER to Golgi vesicle-mediated transport|actin polymerization or depolymerization|positive regulation of actin nucleation|Rho GTPase binding|actin filament polymerization|GTP-Rho binding - - - - 15:82809628-82836108 546 580 614 261 325 276 7.35103053203623 7.09682071853369 7.45312575193682 3.14843120014874 3.5901050582535 3.48252622326103 7.30032566750225 3.40702082722109 1.09945005734938 2.73524912583e-08 4.66617870871593e-07 UP ENSG00000170100 ZNF778 zinc finger protein 778 [Source:HGNC Symbol;Acc:HGNC:26479] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 16:89217703-89237071 279 651 266 108 106 123 1.09289836002593 2.3175913211946 0.939444821832408 0.379049485474026 0.340681611578825 0.451556342491713 1.44997816768431 0.390429146514855 1.89289851491376 2.84231838173288e-08 4.84606356186485e-07 UP ENSG00000110925 CSRNP2 cysteine-serine-rich nuclear protein 2 [Source:HGNC Symbol;Acc:HGNC:16006] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0019899|GO:0000981|GO:0006139|GO:0044092|GO:0008219|GO:0050790|GO:0043086|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0043412|GO:0051252|GO:0010628|GO:0036211|GO:0032269|GO:0019902|GO:0051346|GO:0012501|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0010923|GO:0016311|GO:0032774|GO:0043565|GO:2001141|GO:0006464|GO:0006351|GO:0006915|GO:0006355|GO:0010921|GO:0006470|GO:0035304|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0035305|GO:0035303|GO:0035308 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|negative regulation of molecular function|cell death|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|regulation of RNA metabolic process|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|phosphatase binding|negative regulation of hydrolase activity|programmed cell death|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|negative regulation of phosphatase activity|dephosphorylation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|cellular protein modification process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation - - - - 12:51061205-51083664 715 745 546 314 322 255 6.54970859513389 6.20229620860922 4.50943821720451 2.57717515364227 2.42013473383317 2.18919717350818 5.75381434031587 2.39550235366121 1.26419043908 2.85001717046364e-08 4.85641624469301e-07 UP ENSG00000113648 H2AFY H2A histone family member Y [Source:HGNC Symbol;Acc:HGNC:4740] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0032259|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0030234|GO:0032993|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0004857|GO:0045595|GO:0006725|GO:0009888|GO:0045684|GO:0022402|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0034641|GO:0031982|GO:0046483|GO:0051128|GO:0022607|GO:0045786|GO:0045597|GO:0043231|GO:0019899|GO:0032403|GO:0031519|GO:0046983|GO:0045184|GO:0009890|GO:0003682|GO:0016458|GO:0006139|GO:0000790|GO:0008104|GO:0044092|GO:0006629|GO:0070062|GO:0050790|GO:0019207|GO:0043086|GO:0048869|GO:0044249|GO:0000786|GO:0019538|GO:0000792|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0032268|GO:0003677|GO:0045682|GO:0019210|GO:0010468|GO:0034645|GO:0005720|GO:0043412|GO:0072594|GO:0010629|GO:0016572|GO:0019887|GO:0031056|GO:0046982|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0044770|GO:0010628|GO:0036211|GO:0032269|GO:0030856|GO:0031981|GO:0005721|GO:1990234|GO:0010564|GO:0005654|GO:0030858|GO:0031491|GO:0005694|GO:0000228|GO:0006461|GO:0043588|GO:0034613|GO:0006342|GO:0019900|GO:0060429|GO:0006796|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0019216|GO:0045606|GO:0051246|GO:0009059|GO:0030154|GO:0035097|GO:0016070|GO:0005634|GO:0035098|GO:0010948|GO:0031490|GO:0045814|GO:0000975|GO:0033365|GO:0033128|GO:0006334|GO:0000781|GO:0034622|GO:2001251|GO:0043566|GO:0030855|GO:0000803|GO:0045892|GO:0001740|GO:0032774|GO:0000793|GO:0043565|GO:0034660|GO:0030216|GO:2001141|GO:0034728|GO:0016310|GO:0033044|GO:1902679|GO:0008544|GO:0045604|GO:0031492|GO:0003690|GO:0040029|GO:0031061|GO:0006333|GO:0031060|GO:0045815|GO:0018022|GO:0065004|GO:0045618|GO:0004860|GO:0034968|GO:0031497|GO:0000784|GO:0016568|GO:0033673|GO:1901987|GO:0001739|GO:0019901|GO:0006464|GO:0071103|GO:0043549|GO:0006351|GO:0006355|GO:0000775|GO:0061086|GO:0051572|GO:0006323|GO:0030291|GO:0045616|GO:0070734|GO:0006366|GO:0034502|GO:0045859|GO:1903507|GO:0006469|GO:0006357|GO:0006360|GO:0016479|GO:0051568|GO:0006468|GO:1903506|GO:1902750|GO:0044212|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:0071169|GO:0007549|GO:0051569|GO:0006356|GO:1902749|GO:0001933|GO:0000122|GO:0000805|GO:0061085|GO:0010385|GO:0009913|GO:0009303|GO:0071168|GO:1901837|GO:0001047|GO:0000182|GO:0000976|GO:0001012|GO:0071901|GO:0071900|GO:0018205|GO:0001046|GO:0000977|GO:0000979 developmental process|macromolecular complex|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|methylation|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|protein-DNA complex|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|enzyme inhibitor activity|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|positive regulation of epidermis development|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|protein complex binding|PcG protein complex|protein dimerization activity|establishment of protein localization|negative regulation of biosynthetic process|chromatin binding|gene silencing|nucleobase-containing compound metabolic process|nuclear chromatin|protein localization|negative regulation of molecular function|lipid metabolic process|extracellular exosome|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|nucleosome|protein metabolic process|heterochromatin|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|regulation of cellular protein metabolic process|DNA binding|regulation of epidermis development|kinase inhibitor activity|regulation of gene expression|cellular macromolecule biosynthetic process|nuclear heterochromatin|macromolecule modification|establishment of protein localization to organelle|negative regulation of gene expression|histone phosphorylation|protein kinase regulator activity|regulation of histone modification|protein heterodimerization activity|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|cell cycle phase transition|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|regulation of epithelial cell differentiation|nuclear lumen|pericentric heterochromatin|transferase complex|regulation of cell cycle process|nucleoplasm|positive regulation of epithelial cell differentiation|nucleosome binding|chromosome|nuclear chromosome|protein complex assembly|skin development|cellular protein localization|chromatin silencing|kinase binding|epithelium development|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of lipid metabolic process|positive regulation of epidermal cell differentiation|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|histone methyltransferase complex|RNA metabolic process|nucleus|ESC/E(Z) complex|negative regulation of cell cycle process|chromatin DNA binding|negative regulation of gene expression, epigenetic|regulatory region DNA binding|protein localization to organelle|negative regulation of histone phosphorylation|nucleosome assembly|chromosome, telomeric region|cellular macromolecular complex assembly|negative regulation of chromosome organization|structure-specific DNA binding|epithelial cell differentiation|sex chromosome|negative regulation of transcription, DNA-templated|Barr body|RNA biosynthetic process|condensed chromosome|sequence-specific DNA binding|ncRNA metabolic process|keratinocyte differentiation|regulation of RNA biosynthetic process|nucleosome organization|phosphorylation|regulation of chromosome organization|negative regulation of RNA biosynthetic process|epidermis development|regulation of epidermal cell differentiation|nucleosomal DNA binding|double-stranded DNA binding|regulation of gene expression, epigenetic|negative regulation of histone methylation|chromatin assembly or disassembly|regulation of histone methylation|positive regulation of gene expression, epigenetic|peptidyl-lysine methylation|protein-DNA complex assembly|positive regulation of keratinocyte differentiation|protein kinase inhibitor activity|histone lysine methylation|chromatin assembly|nuclear chromosome, telomeric region|chromatin modification|negative regulation of kinase activity|regulation of cell cycle phase transition|sex chromatin|protein kinase binding|cellular protein modification process|DNA conformation change|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|chromosome, centromeric region|negative regulation of histone H3-K27 methylation|negative regulation of histone H3-K4 methylation|DNA packaging|protein serine/threonine kinase inhibitor activity|regulation of keratinocyte differentiation|histone H3-K27 methylation|transcription from RNA polymerase II promoter|protein localization to chromosome|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|negative regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase I promoter|negative regulation of transcription from RNA polymerase I promoter|histone H3-K4 methylation|protein phosphorylation|regulation of nucleic acid-templated transcription|negative regulation of cell cycle G2/M phase transition|transcription regulatory region DNA binding|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|establishment of protein localization to chromatin|dosage compensation|regulation of histone H3-K4 methylation|regulation of transcription from RNA polymerase I promoter|regulation of cell cycle G2/M phase transition|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|X chromosome|regulation of histone H3-K27 methylation|double-stranded methylated DNA binding|epidermal cell differentiation|rRNA transcription|protein localization to chromatin|negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter|core promoter binding|rDNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|peptidyl-lysine modification|core promoter sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding K11251 histone H2A[-] hsa05034|hsa05322 Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 5:135333900-135399914 1212 1607 1629 3282 3573 3494 3.12814441383989 3.76946935324384 3.79070103967307 7.58962926881886 7.566327841799 8.4515433010148 3.56277160225227 7.86916680387755 -1.14321088973622 2.90290979869428e-08 4.94372328181512e-07 DOWN ENSG00000186193 SAPCD2 suppressor APC domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28055] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0005730|GO:0031981|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|nucleolus|nuclear lumen|nucleus - - - - 9:137062124-137070588 768 818 837 2114 2607 1564 14.1179558888381 13.6660795088343 13.872365171517 34.8187718648663 39.3205576705317 26.9448938070622 13.8854668563965 33.6947411141534 -1.2789477570571 2.93110619176325e-08 4.98889647941278e-07 DOWN ENSG00000076242 MLH1 mutL homolog 1 [Source:HGNC Symbol;Acc:HGNC:7127] GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0016043|GO:0043227|GO:0090220|GO:0032504|GO:0016787|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0002250|GO:0007049|GO:0007131|GO:0006281|GO:0016445|GO:0006725|GO:0051640|GO:0048468|GO:0022402|GO:1901360|GO:0045190|GO:0007275|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0022607|GO:0043231|GO:0051311|GO:0002377|GO:0032403|GO:0051656|GO:0001775|GO:0002312|GO:0002263|GO:0003682|GO:0070192|GO:0051307|GO:0045141|GO:0006139|GO:0046649|GO:0032300|GO:0007154|GO:0007276|GO:0007165|GO:0007126|GO:0002366|GO:0002566|GO:0051649|GO:0008219|GO:0007059|GO:0000166|GO:0048869|GO:0007017|GO:1990391|GO:0031324|GO:0007281|GO:0031323|GO:0002443|GO:0006996|GO:0051276|GO:0003677|GO:0042113|GO:0051053|GO:0048232|GO:0035639|GO:0007010|GO:0016446|GO:0051304|GO:0016447|GO:0001883|GO:0000712|GO:0032389|GO:0007129|GO:0044265|GO:0048477|GO:0006302|GO:0016818|GO:0051255|GO:0032549|GO:0007140|GO:0007127|GO:0031981|GO:0045132|GO:0043060|GO:0006298|GO:0005654|GO:0006259|GO:0007143|GO:0007051|GO:0005694|GO:0000228|GO:0006461|GO:0051257|GO:0002460|GO:0070925|GO:0012501|GO:0002381|GO:0035556|GO:0017076|GO:0019439|GO:0030154|GO:0016070|GO:0000226|GO:0007292|GO:0005634|GO:0006974|GO:0051303|GO:0097190|GO:0006401|GO:0007283|GO:0006303|GO:0051225|GO:0097193|GO:0045910|GO:0007060|GO:0003697|GO:0000793|GO:0005524|GO:0032407|GO:0030554|GO:0005712|GO:0016321|GO:0003690|GO:0000794|GO:0045143|GO:0008630|GO:0016071|GO:0000018|GO:0006310|GO:0051310|GO:0000795|GO:0019724|GO:0002204|GO:0016462|GO:0006915|GO:0016064|GO:0006402|GO:0017111|GO:0045950|GO:0016444|GO:0006312|GO:0000019|GO:0030983|GO:0001673|GO:0016887|GO:0032137|GO:0000956|GO:0000289|GO:0000288 developmental process|macromolecular complex|reproduction|immune system process|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|catabolic process|ion binding|immune response|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|chromosome localization to nuclear envelope involved in homologous chromosome segregation|multicellular organism reproduction|hydrolase activity|intracellular|immune system development|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|adaptive immune response|cell cycle|reciprocal meiotic recombination|DNA repair|somatic diversification of immunoglobulins|cellular aromatic compound metabolic process|organelle localization|cell development|cell cycle process|organic cyclic compound metabolic process|isotype switching|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|meiotic metaphase plate congression|immunoglobulin production|protein complex binding|establishment of organelle localization|cell activation|B cell activation involved in immune response|cell activation involved in immune response|chromatin binding|chromosome organization involved in meiotic cell cycle|meiotic chromosome separation|meiotic telomere clustering|nucleobase-containing compound metabolic process|lymphocyte activation|mismatch repair complex|cell communication|gamete generation|signal transduction|meiotic nuclear division|leukocyte activation involved in immune response|somatic diversification of immune receptors via somatic mutation|establishment of localization in cell|cell death|chromosome segregation|nucleotide binding|cellular developmental process|microtubule-based process|DNA repair complex|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|leukocyte mediated immunity|organelle organization|chromosome organization|DNA binding|B cell activation|negative regulation of DNA metabolic process|male gamete generation|purine ribonucleoside triphosphate binding|cytoskeleton organization|somatic hypermutation of immunoglobulin genes|chromosome separation|somatic recombination of immunoglobulin gene segments|purine nucleoside binding|resolution of meiotic recombination intermediates|MutLalpha complex|synapsis|cellular macromolecule catabolic process|oogenesis|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|spindle midzone assembly|ribonucleoside binding|male meiosis|meiosis I|nuclear lumen|meiotic chromosome segregation|meiotic metaphase I plate congression|mismatch repair|nucleoplasm|DNA metabolic process|female meiotic division|spindle organization|chromosome|nuclear chromosome|protein complex assembly|meiotic spindle midzone assembly|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|organelle assembly|programmed cell death|immunoglobulin production involved in immunoglobulin mediated immune response|intracellular signal transduction|purine nucleotide binding|aromatic compound catabolic process|cell differentiation|RNA metabolic process|microtubule cytoskeleton organization|female gamete generation|nucleus|cellular response to DNA damage stimulus|establishment of chromosome localization|apoptotic signaling pathway|RNA catabolic process|spermatogenesis|double-strand break repair via nonhomologous end joining|spindle assembly|intrinsic apoptotic signaling pathway|negative regulation of DNA recombination|male meiosis chromosome segregation|single-stranded DNA binding|condensed chromosome|ATP binding|MutSalpha complex binding|adenyl nucleotide binding|chiasma|female meiosis chromosome segregation|double-stranded DNA binding|condensed nuclear chromosome|homologous chromosome segregation|intrinsic apoptotic signaling pathway in response to DNA damage|mRNA metabolic process|regulation of DNA recombination|DNA recombination|metaphase plate congression|synaptonemal complex|B cell mediated immunity|somatic recombination of immunoglobulin genes involved in immune response|pyrophosphatase activity|apoptotic process|immunoglobulin mediated immune response|mRNA catabolic process|nucleoside-triphosphatase activity|negative regulation of mitotic recombination|somatic cell DNA recombination|mitotic recombination|regulation of mitotic recombination|mismatched DNA binding|male germ cell nucleus|ATPase activity|guanine/thymine mispair binding|nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K08734 DNA mismatch repair protein MLH1[-] hsa05200|hsa05210|hsa03460|hsa05213|hsa03430 Pathways in cancer - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Fanconi anemia pathway - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Mismatch repair - Homo sapiens (human) 3:36993332-37050918 256 292 231 733 837 582 2.30360685753287 2.38797763733473 1.874107988207 5.90975627332588 6.17961324019057 4.90817573662507 2.18856416102487 5.66584841671384 -1.37230732522328 2.97599342407025e-08 5.06241069414206e-07 DOWN ENSG00000075391 RASAL2 RAS protein activator like 2 [Source:HGNC Symbol;Acc:HGNC:9874] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0031224|GO:0030234|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0009898|GO:0006935|GO:0045087|GO:0048468|GO:0007275|GO:0008047|GO:0006952|GO:0031325|GO:0010243|GO:0005737|GO:0006928|GO:0098562|GO:0009966|GO:0010646|GO:0031226|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0005096|GO:0007166|GO:0043412|GO:0051345|GO:0030695|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0031235|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:1902532|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:1901653|GO:0043408|GO:0071363|GO:0043087|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0043547|GO:0007167|GO:0071375|GO:0043410|GO:0032868|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0051058|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0042327|GO:0046580|GO:0007169|GO:0048010|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|enzyme regulator activity|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|cytoplasmic side of plasma membrane|chemotaxis|innate immune response|cell development|multicellular organism development|enzyme activator activity|defense response|positive regulation of cellular metabolic process|response to organonitrogen compound|cytoplasm|movement of cell or subcellular component|cytoplasmic side of membrane|regulation of signal transduction|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|GTPase activator activity|cell surface receptor signaling pathway|macromolecule modification|positive regulation of hydrolase activity|GTPase regulator activity|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|intrinsic component of the cytoplasmic side of the plasma membrane|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular response to peptide|regulation of MAPK cascade|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|response to insulin|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|negative regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K17633 RAS protein activator-like 2[-] hsa04014 Ras signaling pathway - Homo sapiens (human) 1:178094141-178484147 197 240 432 757 860 822 0.786230048510666 0.870511876493832 1.5544676275496 2.70693243110848 2.81611446073623 3.07457249070601 1.0704031841847 2.86587312751691 -1.42082043000418 2.99529151757989e-08 5.09233672926139e-07 DOWN ENSG00000134369 NAV1 neuron navigator 1 [Source:HGNC Symbol;Acc:HGNC:15989] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0048870|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0007275|GO:0043168|GO:0005874|GO:0001882|GO:0005737|GO:0006928|GO:0016477|GO:0000166|GO:0048869|GO:0007017|GO:0006996|GO:0035639|GO:0007010|GO:0001883|GO:0001764|GO:0032549|GO:0007399|GO:0017076|GO:0030154|GO:0000226|GO:0005856|GO:0005524|GO:0030554|GO:0015630|GO:0001578|GO:0022008|GO:0048699 locomotion|developmental process|cell|cellular process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|cell motility|cellular component organization|intracellular|protein binding|anatomical structure development|multicellular organism development|anion binding|microtubule|nucleoside binding|cytoplasm|movement of cell or subcellular component|cell migration|nucleotide binding|cellular developmental process|microtubule-based process|organelle organization|purine ribonucleoside triphosphate binding|cytoskeleton organization|purine nucleoside binding|neuron migration|ribonucleoside binding|nervous system development|purine nucleotide binding|cell differentiation|microtubule cytoskeleton organization|cytoskeleton|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|microtubule bundle formation|neurogenesis|generation of neurons - - - - 1:201622885-201826969 263 292 399 738 772 1227 0.639966342558567 0.64574792594043 0.875363214218376 1.60899436768293 1.54129540027263 2.79817112168106 0.720359160905791 1.98282029654554 -1.46076563329048 3.00237866321774e-08 5.10148051290281e-07 DOWN ENSG00000086589 RBM22 RNA binding motif protein 22 [Source:HGNC Symbol;Acc:HGNC:25503] GO:0032991|GO:0005215|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0005487|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:1903829|GO:0005515|GO:0043234|GO:0019222|GO:0060341|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0030529|GO:0032880|GO:0051222|GO:0045184|GO:0048306|GO:0042493|GO:0032388|GO:0006139|GO:0008104|GO:0051649|GO:0090316|GO:0000166|GO:0000974|GO:0022613|GO:0031323|GO:0010468|GO:0046872|GO:0003723|GO:0072594|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0010628|GO:0070201|GO:0046907|GO:0022618|GO:0031981|GO:0005681|GO:0005654|GO:0034613|GO:0010467|GO:0017038|GO:0035690|GO:1903827|GO:0016070|GO:0005634|GO:0006606|GO:0033365|GO:0033157|GO:0071012|GO:0017069|GO:0034622|GO:0051169|GO:0006396|GO:0043484|GO:0006605|GO:0005684|GO:0006886|GO:0016071|GO:0036002|GO:0044822|GO:0000387|GO:0033120|GO:0000060|GO:0071013|GO:0006913|GO:0006397|GO:0008380|GO:0071006|GO:0017070|GO:0071007|GO:0034504|GO:0000375|GO:0051170|GO:0000398|GO:0045292 macromolecular complex|transporter activity|cell|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|nucleocytoplasmic transporter activity|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|positive regulation of cellular protein localization|protein binding|protein complex|regulation of metabolic process|regulation of cellular localization|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|intracellular ribonucleoprotein complex|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|calcium-dependent protein binding|response to drug|positive regulation of intracellular transport|nucleobase-containing compound metabolic process|protein localization|establishment of localization in cell|positive regulation of intracellular protein transport|nucleotide binding|Prp19 complex|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|regulation of gene expression|metal ion binding|RNA binding|establishment of protein localization to organelle|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|positive regulation of gene expression|regulation of establishment of protein localization|intracellular transport|ribonucleoprotein complex assembly|nuclear lumen|spliceosomal complex|nucleoplasm|cellular protein localization|gene expression|protein import|cellular response to drug|regulation of cellular protein localization|RNA metabolic process|nucleus|protein import into nucleus|protein localization to organelle|regulation of intracellular protein transport|catalytic step 1 spliceosome|snRNA binding|cellular macromolecular complex assembly|nuclear transport|RNA processing|regulation of RNA splicing|protein targeting|U2-type spliceosomal complex|intracellular protein transport|mRNA metabolic process|pre-mRNA binding|poly(A) RNA binding|spliceosomal snRNP assembly|positive regulation of RNA splicing|protein import into nucleus, translocation|catalytic step 2 spliceosome|nucleocytoplasmic transport|mRNA processing|RNA splicing|U2-type catalytic step 1 spliceosome|U6 snRNA binding|U2-type catalytic step 2 spliceosome|protein localization to nucleus|RNA splicing, via transesterification reactions|nuclear import|mRNA splicing, via spliceosome|mRNA cis splicing, via spliceosome K12872 pre-mRNA-splicing factor RBM22/SLT11[-] hsa03040 Spliceosome - Homo sapiens (human) 5:150690794-150701107 2343 2321 1696 997 1107 775 30.0737538356192 27.0751299397796 19.6270681828287 11.4658976753603 11.6581870898997 9.32278528252914 25.5919839860758 10.815623349263 1.24257517861565 3.00998659040349e-08 5.11149827473867e-07 UP ENSG00000177595 PIDD1 p53-induced death domain protein 1 [Source:HGNC Symbol;Acc:HGNC:16491] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0010941|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0045786|GO:0043231|GO:0005737|GO:0009966|GO:0045787|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0009967|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0051090|GO:2001235|GO:0032268|GO:0010468|GO:0005126|GO:0000075|GO:0034645|GO:0090068|GO:0007166|GO:1903047|GO:0051345|GO:0043069|GO:0051252|GO:0044770|GO:0051604|GO:0007050|GO:0010628|GO:0000278|GO:0051091|GO:0007346|GO:0010564|GO:0051247|GO:0045930|GO:0006508|GO:0032270|GO:0012501|GO:0035556|GO:0044267|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0043068|GO:0072395|GO:0016070|GO:0010557|GO:0005634|GO:0043067|GO:0006974|GO:0097190|GO:0010948|GO:0045893|GO:0043065|GO:0071156|GO:0016485|GO:0032813|GO:0007093|GO:0072331|GO:0042770|GO:0032774|GO:0044772|GO:0030162|GO:2001141|GO:0045862|GO:2001236|GO:0051092|GO:0044774|GO:0052547|GO:2001238|GO:0000077|GO:1901990|GO:0042981|GO:0043066|GO:1901987|GO:0010952|GO:0097191|GO:0006351|GO:0006915|GO:0006355|GO:0044773|GO:1901991|GO:0071158|GO:2000045|GO:0010950|GO:1902043|GO:0043281|GO:0044819|GO:1903506|GO:0044783|GO:1902806|GO:2000134|GO:0000082|GO:0031638|GO:0043280|GO:0006919|GO:0031571|GO:1902807|GO:0006977|GO:0030330|GO:0008625|GO:0072422|GO:1902041|GO:0052548|GO:0005123|GO:0072431|GO:2001056|GO:2000116|GO:0097202 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|endomembrane system|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|positive regulation of cell cycle|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of sequence-specific DNA binding transcription factor activity|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of gene expression|cytokine receptor binding|cell cycle checkpoint|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|cell surface receptor signaling pathway|mitotic cell cycle process|positive regulation of hydrolase activity|negative regulation of programmed cell death|regulation of RNA metabolic process|cell cycle phase transition|protein maturation|cell cycle arrest|positive regulation of gene expression|mitotic cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|proteolysis|positive regulation of cellular protein metabolic process|programmed cell death|intracellular signal transduction|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of programmed cell death|signal transduction involved in cell cycle checkpoint|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|negative regulation of cell cycle process|positive regulation of transcription, DNA-templated|positive regulation of apoptotic process|regulation of cell cycle arrest|protein processing|tumor necrosis factor receptor superfamily binding|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of proteolysis|regulation of RNA biosynthetic process|positive regulation of proteolysis|regulation of extrinsic apoptotic signaling pathway|positive regulation of NF-kappaB transcription factor activity|mitotic DNA integrity checkpoint|regulation of peptidase activity|positive regulation of extrinsic apoptotic signaling pathway|DNA damage checkpoint|regulation of mitotic cell cycle phase transition|regulation of apoptotic process|negative regulation of apoptotic process|regulation of cell cycle phase transition|positive regulation of peptidase activity|extrinsic apoptotic signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|regulation of G1/S transition of mitotic cell cycle|positive regulation of endopeptidase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of cysteine-type endopeptidase activity involved in apoptotic process|mitotic G1/S transition checkpoint|regulation of nucleic acid-templated transcription|G1 DNA damage checkpoint|regulation of cell cycle G1/S phase transition|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|mitotic G1 DNA damage checkpoint|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|extrinsic apoptotic signaling pathway via death domain receptors|signal transduction involved in DNA damage checkpoint|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of endopeptidase activity|death receptor binding|signal transduction involved in mitotic G1 DNA damage checkpoint|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity K10130 leucine-rich repeats and death domain-containing protein[-] hsa04210|hsa04064|hsa04115 Apoptosis - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 11:799179-809753 110 106 155 320 360 366 0.54780507103933 0.479755985664698 0.69595638131882 1.42784902378588 1.47097670524375 1.70822409381245 0.574505812674283 1.53568327428069 -1.41848730449459 3.01440117037703e-08 5.11608485164502e-07 DOWN ENSG00000276115 RP11-817I4.2 - - - - - - - 12:32352349-32354144 0 0 1 10 13 23 0 0 0.0354925823050359 0.352900070193957 0.420085317651995 0.8489886937298 0.0118308607683453 0.540658027191917 -5.51408941267824 3.02615323432365e-08 5.1331124237215e-07 DOWN ENSG00000104635 SLC39A14 solute carrier family 39 (zinc transporter), member 14 [Source:HGNC Symbol;Acc:HGNC:20858] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0042995|GO:0022857|GO:0043229|GO:0043227|GO:0071944|GO:0031252|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0006810|GO:0005887|GO:0043231|GO:0005737|GO:0042592|GO:0030027|GO:0019725|GO:0022891|GO:0031226|GO:0055085|GO:0005783|GO:0016021|GO:0005794|GO:0048878|GO:0006811|GO:0055082|GO:0015075|GO:0034220|GO:0098655|GO:0006812|GO:0050801|GO:0006873|GO:0008324|GO:0022890|GO:0030001|GO:0030003|GO:0055065|GO:0006875|GO:0034755|GO:0071577|GO:0046873|GO:0015093|GO:0006882|GO:0046915|GO:0055069|GO:0071578|GO:0015684|GO:1903874|GO:0006829|GO:0005385|GO:0006826|GO:0005381 transporter activity|cell|membrane|cellular process|cell projection|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|cell periphery|cell leading edge|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|transport|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|lamellipodium|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|endoplasmic reticulum|integral component of membrane|Golgi apparatus|chemical homeostasis|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|cation transport|ion homeostasis|cellular ion homeostasis|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|iron ion transmembrane transport|zinc II ion transmembrane transport|metal ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|cellular zinc ion homeostasis|transition metal ion transmembrane transporter activity|zinc ion homeostasis|zinc II ion transmembrane import|ferrous iron transport|ferrous iron transmembrane transport|zinc II ion transport|zinc ion transmembrane transporter activity|iron ion transport|iron ion transmembrane transporter activity - - - - 8:22367249-22434129 513 536 784 1475 1742 1305 2.84678806359187 2.70322858427057 3.92254840720972 7.33377137707578 7.93147354819903 6.78698966795983 3.15752168502405 7.35074486441155 -1.21909780618668 3.05094283365762e-08 5.17222301851304e-07 DOWN ENSG00000167034 NKX3-1 NK3 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7838] GO:0032502|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0009628|GO:0044237|GO:0051641|GO:0038023|GO:0003006|GO:0023051|GO:0009653|GO:0043227|GO:0004879|GO:0023057|GO:0009893|GO:0009058|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0098531|GO:0007507|GO:0045137|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0001756|GO:0071899|GO:0060770|GO:0035239|GO:0006725|GO:0003707|GO:0001822|GO:0046887|GO:0009888|GO:0006810|GO:0022402|GO:0035295|GO:1901360|GO:2001022|GO:0001568|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0043028|GO:0051302|GO:0005102|GO:0034641|GO:0008047|GO:0032940|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0051098|GO:0045786|GO:0043231|GO:0060740|GO:0048608|GO:0019899|GO:0000981|GO:0007389|GO:0001763|GO:0004882|GO:0007267|GO:0060512|GO:0009887|GO:0009966|GO:0048729|GO:0007548|GO:0050673|GO:0009890|GO:0046883|GO:0045787|GO:0019904|GO:0042493|GO:0010646|GO:0006139|GO:0043085|GO:0008406|GO:0007154|GO:0044092|GO:0007165|GO:0043621|GO:0060768|GO:0009968|GO:0008134|GO:0009725|GO:0008219|GO:0008285|GO:0001666|GO:0051047|GO:0050790|GO:0051781|GO:0051301|GO:0019207|GO:0010817|GO:0009967|GO:0044249|GO:0030850|GO:0010876|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0048732|GO:0032370|GO:1902533|GO:2001235|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0008584|GO:0007166|GO:0016504|GO:0051100|GO:0002009|GO:0033993|GO:0001944|GO:0043412|GO:0046661|GO:0061458|GO:0072358|GO:0034097|GO:0051345|GO:0001655|GO:0010629|GO:0051427|GO:0019887|GO:0043569|GO:0097162|GO:0051252|GO:0048754|GO:0051604|GO:0060664|GO:0061138|GO:0022612|GO:0007050|GO:0009790|GO:0000983|GO:0001656|GO:0010628|GO:0060442|GO:0051347|GO:0036211|GO:0000278|GO:0060840|GO:0071456|GO:0060037|GO:0072001|GO:0003002|GO:0043567|GO:0007431|GO:0051046|GO:2001020|GO:0032368|GO:0007346|GO:0006869|GO:0009914|GO:0042826|GO:0051247|GO:0045930|GO:0006508|GO:0050678|GO:0030284|GO:0035272|GO:0050680|GO:0071453|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0008656|GO:0010467|GO:0019209|GO:0060562|GO:0046903|GO:0071310|GO:0031328|GO:0051246|GO:0035690|GO:0009059|GO:0009755|GO:0043068|GO:1902531|GO:0016070|GO:0045931|GO:0072359|GO:0032870|GO:0010557|GO:0005634|GO:0043067|GO:2000836|GO:0048545|GO:0097305|GO:0006974|GO:0030522|GO:0097190|GO:0046546|GO:0043393|GO:0043401|GO:0043491|GO:0000975|GO:0045893|GO:0097193|GO:0016505|GO:2001242|GO:0009792|GO:0031401|GO:0070555|GO:0043065|GO:2001244|GO:0071850|GO:0016485|GO:0045892|GO:0014068|GO:0032774|GO:0043565|GO:0030162|GO:2001141|GO:0035257|GO:0045862|GO:0016310|GO:1902679|GO:0052547|GO:0071383|GO:0071407|GO:0003690|GO:0030518|GO:0061053|GO:0048017|GO:0007167|GO:0030295|GO:0042981|GO:0009952|GO:0071345|GO:0035904|GO:0007435|GO:0034612|GO:0033574|GO:0014066|GO:0006464|GO:0010952|GO:0032091|GO:0071396|GO:0046879|GO:0043549|GO:0006351|GO:0035282|GO:0006915|GO:0006355|GO:0033674|GO:0036294|GO:0045944|GO:0006366|GO:0045859|GO:1903507|GO:0010950|GO:0048015|GO:0045860|GO:0035258|GO:0071347|GO:0006357|GO:0043281|GO:0006468|GO:0071356|GO:1903506|GO:0044212|GO:0042325|GO:0001932|GO:0035907|GO:0030521|GO:0031638|GO:0043009|GO:0043280|GO:0001934|GO:0006919|GO:0042327|GO:1900121|GO:0007169|GO:0052548|GO:0001047|GO:0048009|GO:2001056|GO:0000976|GO:0014065|GO:2000116|GO:0030331|GO:0097202|GO:0032147 developmental process|signal transducer activity|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|signaling receptor activity|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|heart development|development of primary sexual characteristics|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|somitogenesis|negative regulation of estrogen receptor binding|negative regulation of epithelial cell proliferation involved in prostate gland development|tube morphogenesis|cellular aromatic compound metabolic process|steroid hormone receptor activity|kidney development|positive regulation of hormone secretion|tissue development|transport|cell cycle process|tube development|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|blood vessel development|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|cysteine-type endopeptidase regulator activity involved in apoptotic process|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|enzyme activator activity|secretion by cell|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|regulation of binding|negative regulation of cell cycle|intracellular membrane-bounded organelle|prostate gland epithelium morphogenesis|reproductive structure development|enzyme binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|morphogenesis of a branching structure|androgen receptor activity|cell-cell signaling|prostate gland morphogenesis|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|sex differentiation|epithelial cell proliferation|negative regulation of biosynthetic process|regulation of hormone secretion|positive regulation of cell cycle|protein domain specific binding|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|gonad development|cell communication|negative regulation of molecular function|signal transduction|protein self-association|regulation of epithelial cell proliferation involved in prostate gland development|negative regulation of signal transduction|transcription factor binding|response to hormone|cell death|negative regulation of cell proliferation|response to hypoxia|positive regulation of secretion|regulation of catalytic activity|positive regulation of cell division|cell division|kinase regulator activity|regulation of hormone levels|positive regulation of signal transduction|cellular biosynthetic process|prostate gland development|lipid localization|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|positive regulation of lipid transport|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gonad development|cell surface receptor signaling pathway|peptidase activator activity|negative regulation of binding|morphogenesis of an epithelium|response to lipid|vasculature development|macromolecule modification|male sex differentiation|reproductive system development|cardiovascular system development|response to cytokine|positive regulation of hydrolase activity|urogenital system development|negative regulation of gene expression|hormone receptor binding|protein kinase regulator activity|negative regulation of insulin-like growth factor receptor signaling pathway|MADS box domain binding|regulation of RNA metabolic process|branching morphogenesis of an epithelial tube|protein maturation|epithelial cell proliferation involved in salivary gland morphogenesis|morphogenesis of a branching epithelium|gland morphogenesis|cell cycle arrest|embryo development|transcription factor activity, RNA polymerase II core promoter sequence-specific|metanephros development|positive regulation of gene expression|branching involved in prostate gland morphogenesis|positive regulation of transferase activity|protein modification process|mitotic cell cycle|artery development|cellular response to hypoxia|pharyngeal system development|renal system development|regionalization|regulation of insulin-like growth factor receptor signaling pathway|salivary gland development|regulation of secretion|regulation of response to DNA damage stimulus|regulation of lipid transport|regulation of mitotic cell cycle|lipid transport|hormone transport|histone deacetylase binding|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|proteolysis|regulation of epithelial cell proliferation|estrogen receptor activity|exocrine system development|negative regulation of epithelial cell proliferation|cellular response to oxygen levels|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cysteine-type endopeptidase activator activity involved in apoptotic process|gene expression|kinase activator activity|epithelial tube morphogenesis|secretion|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cellular response to drug|macromolecule biosynthetic process|hormone-mediated signaling pathway|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of mitotic cell cycle|circulatory system development|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|positive regulation of androgen secretion|response to steroid hormone|response to alcohol|cellular response to DNA damage stimulus|intracellular receptor signaling pathway|apoptotic signaling pathway|development of primary male sexual characteristics|regulation of protein binding|steroid hormone mediated signaling pathway|protein kinase B signaling|regulatory region DNA binding|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|peptidase activator activity involved in apoptotic process|regulation of intrinsic apoptotic signaling pathway|embryo development ending in birth or egg hatching|positive regulation of protein modification process|response to interleukin-1|positive regulation of apoptotic process|positive regulation of intrinsic apoptotic signaling pathway|mitotic cell cycle arrest|protein processing|negative regulation of transcription, DNA-templated|positive regulation of phosphatidylinositol 3-kinase signaling|RNA biosynthetic process|sequence-specific DNA binding|regulation of proteolysis|regulation of RNA biosynthetic process|nuclear hormone receptor binding|positive regulation of proteolysis|phosphorylation|negative regulation of RNA biosynthetic process|regulation of peptidase activity|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|somite development|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|protein kinase activator activity|regulation of apoptotic process|anterior/posterior pattern specification|cellular response to cytokine stimulus|aorta development|salivary gland morphogenesis|response to tumor necrosis factor|response to testosterone|regulation of phosphatidylinositol 3-kinase signaling|cellular protein modification process|positive regulation of peptidase activity|negative regulation of protein binding|cellular response to lipid|hormone secretion|regulation of kinase activity|transcription, DNA-templated|segmentation|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|cellular response to decreased oxygen levels|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of endopeptidase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|steroid hormone receptor binding|cellular response to interleukin-1|regulation of transcription from RNA polymerase II promoter|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of phosphorylation|regulation of protein phosphorylation|dorsal aorta development|androgen receptor signaling pathway|zymogen activation|chordate embryonic development|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of phosphorylation|negative regulation of receptor binding|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|core promoter binding|insulin-like growth factor receptor signaling pathway|positive regulation of cysteine-type endopeptidase activity|transcription regulatory region sequence-specific DNA binding|phosphatidylinositol 3-kinase signaling|regulation of cysteine-type endopeptidase activity|estrogen receptor binding|activation of cysteine-type endopeptidase activity|activation of protein kinase activity K09348 homeobox protein Nkx-3.1[-] hsa05200|hsa05215 Pathways in cancer - Homo sapiens (human)|Prostate cancer - Homo sapiens (human) 8:23678693-23682927 188 225 221 80 84 97 3.33797845953693 3.63069111256238 3.53779678095586 1.2726596018852 1.22369948507129 1.6140795647322 3.50215545101839 1.37014621722956 1.35391326165676 3.07482855149548e-08 5.20975775121147e-07 UP ENSG00000254087 LYN LYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6735] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0019898|GO:0002683|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0060076|GO:0040012|GO:0043229|GO:0006950|GO:0005057|GO:0071704|GO:0050900|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0050795|GO:0001776|GO:0048870|GO:0023051|GO:0005911|GO:0040017|GO:0009653|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0002507|GO:0002262|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0031224|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0016032|GO:0051219|GO:0060341|GO:0002532|GO:0008284|GO:0051272|GO:0002757|GO:0042127|GO:0002250|GO:1903706|GO:0044255|GO:0051282|GO:0050817|GO:0016337|GO:0009898|GO:0006935|GO:0045087|GO:0045595|GO:0051640|GO:0070661|GO:0019866|GO:0002685|GO:0048468|GO:0050867|GO:0044325|GO:0006810|GO:0051130|GO:0010941|GO:0009991|GO:0098797|GO:0007275|GO:0060627|GO:0045596|GO:0048513|GO:0070489|GO:0034101|GO:0005102|GO:0043168|GO:0032940|GO:0006952|GO:0030155|GO:0005912|GO:0001882|GO:0016772|GO:0031982|GO:0019637|GO:0031325|GO:0051128|GO:2000147|GO:0033554|GO:0010942|GO:0001817|GO:0098609|GO:0005887|GO:0034122|GO:0045597|GO:0043231|GO:0045646|GO:0019899|GO:0010243|GO:0005737|GO:0002218|GO:0001816|GO:0007267|GO:0033627|GO:0031668|GO:0009611|GO:0050920|GO:0032880|GO:0009408|GO:0043235|GO:0005758|GO:0006928|GO:0032403|GO:0042592|GO:0031234|GO:0051656|GO:0002696|GO:0001775|GO:0098562|GO:0009966|GO:0002263|GO:0031966|GO:0045184|GO:0050839|GO:0019897|GO:0019725|GO:0014069|GO:0014009|GO:0019904|GO:0042493|GO:0010646|GO:0031226|GO:0043085|GO:0009617|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0055085|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0002366|GO:0050778|GO:0050857|GO:0005913|GO:0002260|GO:0009968|GO:0070062|GO:0051649|GO:0045785|GO:0060369|GO:0008092|GO:0050777|GO:0061351|GO:2000021|GO:0009725|GO:0008219|GO:0051861|GO:0002695|GO:0008285|GO:0030595|GO:0050790|GO:0031295|GO:0000166|GO:0030030|GO:0051238|GO:0046625|GO:0043086|GO:0010817|GO:0043299|GO:0048869|GO:0016021|GO:0002513|GO:2000145|GO:0009967|GO:0009266|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031324|GO:0004716|GO:0031323|GO:0006991|GO:0050878|GO:0005794|GO:0002443|GO:0030061|GO:0009636|GO:0000165|GO:0016192|GO:1902533|GO:0051249|GO:0015631|GO:0032268|GO:0005740|GO:0000902|GO:0006909|GO:0005829|GO:0031175|GO:0009743|GO:0031344|GO:0042113|GO:0030193|GO:0060252|GO:0030168|GO:0032943|GO:0030218|GO:0002688|GO:0007166|GO:0070851|GO:0033993|GO:0035639|GO:0043412|GO:0030097|GO:0002758|GO:0007417|GO:0021782|GO:0034136|GO:0070662|GO:0050727|GO:0002237|GO:0010720|GO:0048678|GO:0048878|GO:0007596|GO:0017124|GO:0043303|GO:0032386|GO:0001883|GO:0033003|GO:0034109|GO:0051223|GO:0015031|GO:1901652|GO:0031346|GO:0000904|GO:0005773|GO:0060251|GO:0071417|GO:0051208|GO:0030334|GO:0043200|GO:0006887|GO:0090218|GO:0051347|GO:0036211|GO:0032269|GO:0033628|GO:0070201|GO:0042060|GO:0071219|GO:0046907|GO:0005178|GO:0048872|GO:0006811|GO:0006954|GO:0051209|GO:0032549|GO:0055082|GO:0045576|GO:0001782|GO:0051251|GO:0051250|GO:0002429|GO:0017157|GO:0022407|GO:0051279|GO:0051046|GO:0005743|GO:0031098|GO:0060326|GO:0050769|GO:0043434|GO:0007599|GO:0007159|GO:0009914|GO:0009306|GO:0034605|GO:0051247|GO:0048471|GO:0034765|GO:0070664|GO:0005739|GO:0002764|GO:0016301|GO:0043269|GO:0050663|GO:0010543|GO:0008305|GO:0002548|GO:0032270|GO:0042110|GO:0012501|GO:0014070|GO:0006796|GO:0034144|GO:0032526|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:2000179|GO:0007399|GO:0019216|GO:0046903|GO:0071310|GO:0043208|GO:0097485|GO:1902532|GO:0017076|GO:0051246|GO:0046651|GO:0010522|GO:0030154|GO:0022409|GO:0032418|GO:0048858|GO:0045121|GO:0030335|GO:0043068|GO:0050707|GO:0034121|GO:1902531|GO:2000177|GO:0060368|GO:0016773|GO:0032870|GO:0032496|GO:0005634|GO:0050861|GO:0043067|GO:0038096|GO:0006644|GO:0045089|GO:0045638|GO:0006974|GO:0051960|GO:0045637|GO:0045088|GO:0044389|GO:0034220|GO:0048666|GO:0002553|GO:0030182|GO:0031625|GO:0002521|GO:0007411|GO:0002761|GO:0070304|GO:0098655|GO:0010975|GO:0045055|GO:0031401|GO:0050863|GO:0043304|GO:0010001|GO:0043065|GO:0034666|GO:0070527|GO:1901653|GO:0043408|GO:0000323|GO:0050869|GO:0070668|GO:0043552|GO:0005524|GO:0043550|GO:0006812|GO:0015696|GO:0014003|GO:0050708|GO:0090330|GO:0030554|GO:0016310|GO:0001821|GO:0002768|GO:0034112|GO:0060402|GO:0070371|GO:0070445|GO:0002221|GO:0070486|GO:0060416|GO:0061564|GO:0016482|GO:0002762|GO:0007167|GO:0002765|GO:0070667|GO:0050864|GO:0071375|GO:0002448|GO:1903305|GO:0014015|GO:0048709|GO:0042981|GO:0070447|GO:0050855|GO:1903725|GO:0050801|GO:0004672|GO:0043409|GO:0033673|GO:0032868|GO:0042100|GO:0002431|GO:0032945|GO:0030099|GO:0071300|GO:0006897|GO:0022008|GO:0048667|GO:0006464|GO:0090025|GO:0050870|GO:0043015|GO:0050851|GO:0050767|GO:0048812|GO:0071396|GO:0046879|GO:0010976|GO:0050672|GO:0043549|GO:0005161|GO:0006915|GO:0006873|GO:0090279|GO:0071222|GO:1903039|GO:0061041|GO:0033674|GO:0031663|GO:0045666|GO:0043551|GO:2000108|GO:1903169|GO:0007259|GO:0097028|GO:0002573|GO:0002223|GO:0045859|GO:0002224|GO:0006469|GO:0007409|GO:0005764|GO:0006468|GO:0043407|GO:0048699|GO:0014013|GO:0046425|GO:0051608|GO:0043405|GO:0042325|GO:0004713|GO:0071378|GO:0001932|GO:0018193|GO:0042326|GO:0038093|GO:0042063|GO:0046427|GO:0030889|GO:0030001|GO:0030888|GO:0001934|GO:0051924|GO:0002767|GO:0001933|GO:0002576|GO:0070372|GO:0050853|GO:0071593|GO:0070373|GO:0045664|GO:0030003|GO:0015672|GO:0042327|GO:0007169|GO:0004715|GO:0060397|GO:2000670|GO:0050731|GO:0038094|GO:0070588|GO:0050730|GO:0002774|GO:0034134|GO:0055065|GO:0048013|GO:0046777|GO:0038095|GO:0071901|GO:0060396|GO:0007260|GO:0097553|GO:0006875|GO:0042531|GO:0071900|GO:0034142|GO:0070228|GO:0042629|GO:0018108|GO:0038083|GO:0002902|GO:0006874|GO:0006816|GO:0055074|GO:0001783|GO:0051480|GO:0070509|GO:0060401|GO:0007204 locomotion|developmental process|macromolecular complex|signal transducer activity|immune system process|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|excitatory synapse|regulation of locomotion|intracellular organelle|response to stress|receptor signaling protein activity|organic substance metabolic process|leukocyte migration|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of behavior|leukocyte homeostasis|cell motility|regulation of signaling|cell-cell junction|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|tolerance induction|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|viral process|phosphoprotein binding|regulation of cellular localization|production of molecular mediator involved in inflammatory response|positive regulation of cell proliferation|positive regulation of cellular component movement|immune response-activating signal transduction|regulation of cell proliferation|adaptive immune response|regulation of hemopoiesis|cellular lipid metabolic process|regulation of sequestering of calcium ion|coagulation|single organismal cell-cell adhesion|cytoplasmic side of plasma membrane|chemotaxis|innate immune response|regulation of cell differentiation|organelle localization|leukocyte proliferation|organelle inner membrane|regulation of leukocyte migration|cell development|positive regulation of cell activation|ion channel binding|transport|positive regulation of cellular component organization|regulation of cell death|response to extracellular stimulus|plasma membrane protein complex|multicellular organism development|regulation of vesicle-mediated transport|negative regulation of cell differentiation|animal organ development|T cell aggregation|erythrocyte homeostasis|receptor binding|anion binding|secretion by cell|defense response|regulation of cell adhesion|adherens junction|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|positive regulation of cell death|regulation of cytokine production|cell-cell adhesion|integral component of plasma membrane|negative regulation of toll-like receptor signaling pathway|positive regulation of cell differentiation|intracellular membrane-bounded organelle|regulation of erythrocyte differentiation|enzyme binding|response to organonitrogen compound|cytoplasm|activation of innate immune response|cytokine production|cell-cell signaling|cell adhesion mediated by integrin|cellular response to extracellular stimulus|response to wounding|regulation of chemotaxis|regulation of protein localization|response to heat|receptor complex|mitochondrial intermembrane space|movement of cell or subcellular component|protein complex binding|homeostatic process|extrinsic component of cytoplasmic side of plasma membrane|establishment of organelle localization|positive regulation of leukocyte activation|cell activation|cytoplasmic side of membrane|regulation of signal transduction|cell activation involved in immune response|mitochondrial membrane|establishment of protein localization|cell adhesion molecule binding|extrinsic component of plasma membrane|cellular homeostasis|postsynaptic density|glial cell proliferation|protein domain specific binding|response to drug|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|response to bacterium|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|transmembrane transport|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|positive regulation of antigen receptor-mediated signaling pathway|cell-cell adherens junction|lymphocyte homeostasis|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|positive regulation of cell adhesion|positive regulation of Fc receptor mediated stimulatory signaling pathway|cytoskeletal protein binding|negative regulation of immune response|neural precursor cell proliferation|regulation of ion homeostasis|response to hormone|cell death|glycolipid binding|negative regulation of leukocyte activation|negative regulation of cell proliferation|leukocyte chemotaxis|regulation of catalytic activity|T cell costimulation|nucleotide binding|cell projection organization|sequestering of metal ion|sphingolipid binding|negative regulation of catalytic activity|regulation of hormone levels|leukocyte degranulation|cellular developmental process|integral component of membrane|tolerance induction to self antigen|regulation of cell motility|positive regulation of signal transduction|response to temperature stimulus|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|receptor signaling protein tyrosine kinase activity|regulation of cellular metabolic process|response to sterol depletion|regulation of body fluid levels|Golgi apparatus|leukocyte mediated immunity|mitochondrial crista|response to toxic substance|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|tubulin binding|regulation of cellular protein metabolic process|mitochondrial envelope|cell morphogenesis|phagocytosis|cytosol|neuron projection development|response to carbohydrate|regulation of cell projection organization|B cell activation|regulation of blood coagulation|positive regulation of glial cell proliferation|platelet activation|mononuclear cell proliferation|erythrocyte differentiation|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|growth factor receptor binding|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|hemopoiesis|innate immune response-activating signal transduction|central nervous system development|glial cell development|negative regulation of toll-like receptor 2 signaling pathway|mast cell proliferation|regulation of inflammatory response|response to molecule of bacterial origin|positive regulation of cell development|response to axon injury|chemical homeostasis|blood coagulation|SH3 domain binding|mast cell degranulation|regulation of intracellular transport|purine nucleoside binding|regulation of mast cell activation|homotypic cell-cell adhesion|regulation of protein transport|protein transport|response to peptide|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|vacuole|regulation of glial cell proliferation|cellular response to organonitrogen compound|sequestering of calcium ion|regulation of cell migration|response to amino acid|exocytosis|positive regulation of lipid kinase activity|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of cell adhesion mediated by integrin|regulation of establishment of protein localization|wound healing|cellular response to molecule of bacterial origin|intracellular transport|integrin binding|homeostasis of number of cells|ion transport|inflammatory response|release of sequestered calcium ion into cytosol|ribonucleoside binding|cellular chemical homeostasis|mast cell activation|B cell homeostasis|positive regulation of lymphocyte activation|negative regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|regulation of exocytosis|regulation of cell-cell adhesion|regulation of release of sequestered calcium ion into cytosol|regulation of secretion|mitochondrial inner membrane|stress-activated protein kinase signaling cascade|cell chemotaxis|positive regulation of neurogenesis|response to peptide hormone|hemostasis|leukocyte cell-cell adhesion|hormone transport|protein secretion|cellular response to heat|positive regulation of protein metabolic process|perinuclear region of cytoplasm|regulation of ion transmembrane transport|negative regulation of leukocyte proliferation|mitochondrion|immune response-regulating signaling pathway|kinase activity|regulation of ion transport|cytokine secretion|regulation of platelet activation|integrin complex|monocyte chemotaxis|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|negative regulation of toll-like receptor 4 signaling pathway|response to retinoic acid|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|positive regulation of neural precursor cell proliferation|nervous system development|regulation of lipid metabolic process|secretion|cellular response to organic substance|glycosphingolipid binding|neuron projection guidance|negative regulation of intracellular signal transduction|purine nucleotide binding|regulation of protein metabolic process|lymphocyte proliferation|regulation of calcium ion transport into cytosol|cell differentiation|positive regulation of cell-cell adhesion|lysosome localization|cell projection morphogenesis|membrane raft|positive regulation of cell migration|positive regulation of programmed cell death|regulation of cytokine secretion|regulation of toll-like receptor signaling pathway|regulation of intracellular signal transduction|regulation of neural precursor cell proliferation|regulation of Fc receptor mediated stimulatory signaling pathway|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|response to lipopolysaccharide|nucleus|positive regulation of B cell receptor signaling pathway|regulation of programmed cell death|Fc-gamma receptor signaling pathway involved in phagocytosis|phospholipid metabolic process|positive regulation of innate immune response|negative regulation of myeloid cell differentiation|cellular response to DNA damage stimulus|regulation of nervous system development|regulation of myeloid cell differentiation|regulation of innate immune response|ubiquitin-like protein ligase binding|ion transmembrane transport|neuron development|histamine secretion by mast cell|neuron differentiation|ubiquitin protein ligase binding|leukocyte differentiation|axon guidance|regulation of myeloid leukocyte differentiation|positive regulation of stress-activated protein kinase signaling cascade|cation transmembrane transport|regulation of neuron projection development|regulated exocytosis|positive regulation of protein modification process|regulation of T cell activation|regulation of mast cell degranulation|glial cell differentiation|positive regulation of apoptotic process|integrin alpha2-beta1 complex|platelet aggregation|cellular response to peptide|regulation of MAPK cascade|lytic vacuole|negative regulation of B cell activation|positive regulation of mast cell proliferation|positive regulation of phosphatidylinositol 3-kinase activity|ATP binding|regulation of lipid kinase activity|cation transport|ammonium transport|oligodendrocyte development|regulation of protein secretion|regulation of platelet aggregation|adenyl nucleotide binding|phosphorylation|histamine secretion|immune response-regulating cell surface receptor signaling pathway|positive regulation of homotypic cell-cell adhesion|calcium ion transport into cytosol|ERK1 and ERK2 cascade|regulation of oligodendrocyte progenitor proliferation|pattern recognition receptor signaling pathway|leukocyte aggregation|response to growth hormone|axon development|cytosolic transport|negative regulation of myeloid leukocyte differentiation|enzyme linked receptor protein signaling pathway|immune response-inhibiting signal transduction|negative regulation of mast cell proliferation|regulation of B cell activation|cellular response to peptide hormone stimulus|mast cell mediated immunity|regulation of regulated secretory pathway|positive regulation of gliogenesis|oligodendrocyte differentiation|regulation of apoptotic process|positive regulation of oligodendrocyte progenitor proliferation|regulation of B cell receptor signaling pathway|regulation of phospholipid metabolic process|ion homeostasis|protein kinase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|response to insulin|B cell proliferation|Fc receptor mediated stimulatory signaling pathway|negative regulation of mononuclear cell proliferation|myeloid cell differentiation|cellular response to retinoic acid|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of monocyte chemotaxis|positive regulation of T cell activation|gamma-tubulin binding|antigen receptor-mediated signaling pathway|regulation of neurogenesis|neuron projection morphogenesis|cellular response to lipid|hormone secretion|positive regulation of neuron projection development|negative regulation of lymphocyte proliferation|regulation of kinase activity|platelet-derived growth factor receptor binding|apoptotic process|cellular ion homeostasis|regulation of calcium ion import|cellular response to lipopolysaccharide|positive regulation of leukocyte cell-cell adhesion|regulation of wound healing|positive regulation of kinase activity|lipopolysaccharide-mediated signaling pathway|positive regulation of neuron differentiation|regulation of phosphatidylinositol 3-kinase activity|positive regulation of leukocyte apoptotic process|regulation of calcium ion transmembrane transport|JAK-STAT cascade|dendritic cell differentiation|myeloid leukocyte differentiation|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|toll-like receptor signaling pathway|negative regulation of protein kinase activity|axonogenesis|lysosome|protein phosphorylation|negative regulation of MAP kinase activity|generation of neurons|regulation of gliogenesis|regulation of JAK-STAT cascade|histamine transport|regulation of MAP kinase activity|regulation of phosphorylation|protein tyrosine kinase activity|cellular response to growth hormone stimulus|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|Fc receptor signaling pathway|gliogenesis|positive regulation of JAK-STAT cascade|negative regulation of B cell proliferation|metal ion transport|regulation of B cell proliferation|positive regulation of protein phosphorylation|regulation of calcium ion transport|immune response-inhibiting cell surface receptor signaling pathway|negative regulation of protein phosphorylation|platelet degranulation|regulation of ERK1 and ERK2 cascade|B cell receptor signaling pathway|lymphocyte aggregation|negative regulation of ERK1 and ERK2 cascade|regulation of neuron differentiation|cellular cation homeostasis|monovalent inorganic cation transport|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|non-membrane spanning protein tyrosine kinase activity|JAK-STAT cascade involved in growth hormone signaling pathway|positive regulation of dendritic cell apoptotic process|positive regulation of peptidyl-tyrosine phosphorylation|Fc-gamma receptor signaling pathway|calcium ion transmembrane transport|regulation of peptidyl-tyrosine phosphorylation|Fc receptor mediated inhibitory signaling pathway|toll-like receptor 2 signaling pathway|metal ion homeostasis|ephrin receptor signaling pathway|protein autophosphorylation|Fc-epsilon receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|growth hormone receptor signaling pathway|tyrosine phosphorylation of STAT protein|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|positive regulation of tyrosine phosphorylation of STAT protein|regulation of protein serine/threonine kinase activity|toll-like receptor 4 signaling pathway|regulation of lymphocyte apoptotic process|mast cell granule|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation|regulation of B cell apoptotic process|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|B cell apoptotic process|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K05854 tyrosine-protein kinase Lyn[2.7.10.2] hsa05203|hsa05169|hsa04062|hsa04611|hsa04064|hsa04666|hsa04662|hsa05120|hsa04664|hsa04730 Viral carcinogenesis - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Long-term depression - Homo sapiens (human) 8:55879813-56014168 229 257 320 686 724 596 2.19972133569285 2.24359954630347 2.77138004510027 5.90409969709554 5.70608947721401 5.36545904639437 2.4049003090322 5.65854940690131 -1.23445516865594 3.07730920281181e-08 5.21100334320724e-07 DOWN ENSG00000240882 RP11-174O3.1 - - - - - - - 3:120306726-120307952 31 22 10 0 2 1 1.78715553611774 1.1526655629499 0.519788524830591 0 0.0945952190870184 0.0540226123697784 1.15320320796608 0.0495392771522656 4.54093012720861 3.12767382638174e-08 5.2932865313379e-07 UP ENSG00000237943 PRKCQ-AS1 PRKCQ antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44689] - - - - - - 10:6580419-6616452 4 5 8 33 46 30 0.0294141024839027 0.0334199953272915 0.0530433949447664 0.217431329525676 0.277549229847338 0.206763117614425 0.0386258309186535 0.233914558995813 -2.59834378506102 3.15779076821552e-08 5.34122864556976e-07 DOWN ENSG00000073849 ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 [Source:HGNC Symbol;Acc:HGNC:10860] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0040013|GO:0048523|GO:0048521|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0071704|GO:0006955|GO:0044237|GO:0050795|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0009605|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0006486|GO:0008284|GO:0042127|GO:0044255|GO:0006935|GO:0006959|GO:0045595|GO:0031228|GO:0070661|GO:0048468|GO:0010941|GO:0006082|GO:0034446|GO:0044281|GO:0030155|GO:0031982|GO:0051128|GO:0043231|GO:0005737|GO:0050920|GO:0005975|GO:0031589|GO:0060548|GO:0006629|GO:0005783|GO:0070062|GO:0016757|GO:0050922|GO:0008219|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0010033|GO:0005794|GO:0009311|GO:0000902|GO:0006490|GO:0034645|GO:0032943|GO:0043412|GO:0006487|GO:0043069|GO:0000904|GO:0030173|GO:0006493|GO:0009100|GO:0036211|GO:0006040|GO:0008373|GO:0010810|GO:0070085|GO:0022604|GO:0012501|GO:0005795|GO:1901137|GO:0044267|GO:1900024|GO:0000139|GO:0009059|GO:0030154|GO:0043067|GO:0097305|GO:0009101|GO:0043413|GO:0006054|GO:0010769|GO:0006488|GO:0018279|GO:0097503|GO:0031985|GO:0045471|GO:0003835|GO:0032580|GO:0042981|GO:0043066|GO:0019752|GO:0006464|GO:0006915|GO:0032946|GO:0016266|GO:2000107|GO:1990743|GO:0033028|GO:0033032|GO:0018193|GO:0043687|GO:0000138|GO:0005797|GO:0033033|GO:0006925|GO:2000110|GO:0071888|GO:2000109 locomotion|developmental process|immune system process|behavior|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|negative regulation of locomotion|negative regulation of cellular process|negative regulation of behavior|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|organic substance metabolic process|immune response|cellular metabolic process|regulation of behavior|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|response to external stimulus|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|protein glycosylation|positive regulation of cell proliferation|regulation of cell proliferation|cellular lipid metabolic process|chemotaxis|humoral immune response|regulation of cell differentiation|intrinsic component of Golgi membrane|leukocyte proliferation|cell development|regulation of cell death|organic acid metabolic process|substrate adhesion-dependent cell spreading|small molecule metabolic process|regulation of cell adhesion|vesicle|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|regulation of chemotaxis|carbohydrate metabolic process|cell-substrate adhesion|negative regulation of cell death|lipid metabolic process|endoplasmic reticulum|extracellular exosome|transferase activity, transferring glycosyl groups|negative regulation of chemotaxis|cell death|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|response to organic substance|Golgi apparatus|oligosaccharide metabolic process|cell morphogenesis|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|mononuclear cell proliferation|macromolecule modification|protein N-linked glycosylation|negative regulation of programmed cell death|cell morphogenesis involved in differentiation|integral component of Golgi membrane|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|amino sugar metabolic process|sialyltransferase activity|regulation of cell-substrate adhesion|glycosylation|regulation of cell morphogenesis|programmed cell death|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of substrate adhesion-dependent cell spreading|Golgi membrane|macromolecule biosynthetic process|cell differentiation|regulation of programmed cell death|response to alcohol|glycoprotein biosynthetic process|macromolecule glycosylation|N-acetylneuraminate metabolic process|regulation of cell morphogenesis involved in differentiation|dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|sialylation|Golgi cisterna|response to ethanol|beta-galactoside alpha-2,6-sialyltransferase activity|Golgi cisterna membrane|regulation of apoptotic process|negative regulation of apoptotic process|carboxylic acid metabolic process|cellular protein modification process|apoptotic process|positive regulation of mononuclear cell proliferation|O-glycan processing|negative regulation of leukocyte apoptotic process|protein sialylation|myeloid cell apoptotic process|regulation of myeloid cell apoptotic process|peptidyl-amino acid modification|post-translational protein modification|Golgi trans cisterna|Golgi medial cisterna|negative regulation of myeloid cell apoptotic process|inflammatory cell apoptotic process|negative regulation of macrophage apoptotic process|macrophage apoptotic process|regulation of macrophage apoptotic process K00778 beta-galactoside alpha-2,6-sialyltransferase (sialyltransferase 1)[2.4.99.1] hsa01100|hsa00510|hsa00514 Metabolic pathways - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human)|Other types of O-glycan biosynthesis - Homo sapiens (human) 3:186930485-187078553 239 237 446 767 836 937 0.937716098814342 0.845089634333426 1.57769576563554 2.69629368989046 2.69121607271078 3.44542519153677 1.1201671662611 2.94431165137934 -1.39421634026838 3.20109333249045e-08 5.4114065882316e-07 DOWN ENSG00000079819 EPB41L2 erythrocyte membrane protein band 4.1-like 2 [Source:HGNC Symbol;Acc:HGNC:3379] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0005488|GO:1903561|GO:0019898|GO:0030055|GO:0043229|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0005938|GO:0005924|GO:0005912|GO:0031982|GO:0043231|GO:0005737|GO:0019904|GO:0070062|GO:0008092|GO:0030029|GO:0008180|GO:0006996|GO:0042731|GO:0030864|GO:0007010|GO:0003779|GO:0031981|GO:0005654|GO:0030036|GO:0008091|GO:0005856|GO:0005634|GO:0005925|GO:0030507|GO:0015629|GO:0030866|GO:0030865|GO:0030863 macromolecular complex|structural molecule activity|cell|membrane|cellular process|extracellular region|cell junction|binding|extracellular vesicle|extrinsic component of membrane|cell-substrate junction|intracellular organelle|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|cell cortex|cell-substrate adherens junction|adherens junction|vesicle|intracellular membrane-bounded organelle|cytoplasm|protein domain specific binding|extracellular exosome|cytoskeletal protein binding|actin filament-based process|COP9 signalosome|organelle organization|PH domain binding|cortical actin cytoskeleton|cytoskeleton organization|actin binding|nuclear lumen|nucleoplasm|actin cytoskeleton organization|spectrin|cytoskeleton|nucleus|focal adhesion|spectrin binding|actin cytoskeleton|cortical actin cytoskeleton organization|cortical cytoskeleton organization|cortical cytoskeleton K06107 erythrocyte membrane protein band 4.1[-] hsa04530 Tight junction - Homo sapiens (human) 6:130839347-131063322 302 395 565 1039 1128 967 0.875334149747155 1.04050459929893 1.47648561880819 2.69823781111189 2.68252709443016 2.62677134561767 1.13077478928476 2.66917875038657 -1.23908429992413 3.20751843999406e-08 5.41919951938781e-07 DOWN ENSG00000142546 NOSIP nitric oxide synthase interacting protein [Source:HGNC Symbol;Acc:HGNC:17946] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0009892|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0003676|GO:0044281|GO:2001057|GO:0043231|GO:0005737|GO:0072593|GO:0044092|GO:0019787|GO:0050790|GO:0043086|GO:0019538|GO:0005794|GO:0005829|GO:0051354|GO:0003723|GO:0043412|GO:0004842|GO:0036211|GO:0046209|GO:0051341|GO:0044267|GO:0000139|GO:0005634|GO:0044822|GO:0006464|GO:0032769|GO:0051001|GO:0050999|GO:0032446|GO:0016567 cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|negative regulation of metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|nucleic acid binding|small molecule metabolic process|reactive nitrogen species metabolic process|intracellular membrane-bounded organelle|cytoplasm|reactive oxygen species metabolic process|negative regulation of molecular function|ubiquitin-like protein transferase activity|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|Golgi apparatus|cytosol|negative regulation of oxidoreductase activity|RNA binding|macromolecule modification|ubiquitin-protein transferase activity|protein modification process|nitric oxide metabolic process|regulation of oxidoreductase activity|cellular protein metabolic process|Golgi membrane|nucleus|poly(A) RNA binding|cellular protein modification process|negative regulation of monooxygenase activity|negative regulation of nitric-oxide synthase activity|regulation of nitric-oxide synthase activity|protein modification by small protein conjugation|protein ubiquitination - - - - 19:49555711-49590262 2215 2258 1699 990 1041 606 14.7743609150486 13.6879689431859 10.2174515358211 5.9165420254379 5.69709791887222 3.78823563459935 12.8932604646852 5.13395852630316 1.32847359392002 3.21312355348279e-08 5.42559901389565e-07 UP ENSG00000061676 NCKAP1 NCK-associated protein 1 [Source:HGNC Symbol;Acc:HGNC:7666] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0030055|GO:0044877|GO:0050794|GO:0006950|GO:0044089|GO:0006955|GO:0016043|GO:0043227|GO:0071944|GO:0031252|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0016032|GO:0002757|GO:0045087|GO:0006810|GO:0051130|GO:0007275|GO:0032535|GO:0005924|GO:0006952|GO:0005912|GO:0031982|GO:0051128|GO:0022607|GO:0019899|GO:0005737|GO:0032970|GO:0032403|GO:0030027|GO:0010592|GO:0050776|GO:0007154|GO:0060491|GO:0007165|GO:0050778|GO:0031209|GO:0070062|GO:0008219|GO:0031256|GO:0030030|GO:0031253|GO:0016021|GO:0030029|GO:0031334|GO:0043254|GO:0006996|GO:0016192|GO:0006909|GO:0005829|GO:0031344|GO:0007166|GO:0032956|GO:0031258|GO:0007010|GO:0007417|GO:0031346|GO:0002429|GO:0030031|GO:0002764|GO:0006461|GO:0030036|GO:0012501|GO:0097581|GO:0035556|GO:0032273|GO:0033043|GO:0010591|GO:0007399|GO:0051020|GO:0030832|GO:0038096|GO:0005925|GO:0010638|GO:0030032|GO:1902745|GO:0034622|GO:0030838|GO:0043623|GO:0002768|GO:0008064|GO:0051493|GO:0007167|GO:0031267|GO:0002431|GO:0006897|GO:0007264|GO:0007015|GO:0051495|GO:0030833|GO:0006915|GO:0051125|GO:0051258|GO:0007265|GO:0017016|GO:0045010|GO:0038093|GO:0007169|GO:0008154|GO:0051127|GO:0048010|GO:0017048|GO:0038094|GO:0016601|GO:2000601|GO:0034314|GO:0030041|GO:0034315|GO:0048365 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|cell-substrate junction|macromolecular complex binding|regulation of cellular process|response to stress|positive regulation of cellular component biogenesis|immune response|cellular component organization|membrane-bounded organelle|cell periphery|cell leading edge|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|anatomical structure development|viral process|immune response-activating signal transduction|innate immune response|transport|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component size|cell-substrate adherens junction|defense response|adherens junction|vesicle|regulation of cellular component organization|cellular component assembly|enzyme binding|cytoplasm|regulation of actin filament-based process|protein complex binding|lamellipodium|positive regulation of lamellipodium assembly|regulation of immune response|cell communication|regulation of cell projection assembly|signal transduction|positive regulation of immune response|SCAR complex|extracellular exosome|cell death|leading edge membrane|cell projection organization|cell projection membrane|integral component of membrane|actin filament-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|organelle organization|vesicle-mediated transport|phagocytosis|cytosol|regulation of cell projection organization|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|lamellipodium membrane|cytoskeleton organization|central nervous system development|positive regulation of cell projection organization|immune response-activating cell surface receptor signaling pathway|cell projection assembly|immune response-regulating signaling pathway|protein complex assembly|actin cytoskeleton organization|programmed cell death|lamellipodium organization|intracellular signal transduction|positive regulation of protein polymerization|regulation of organelle organization|regulation of lamellipodium assembly|nervous system development|GTPase binding|regulation of actin filament length|Fc-gamma receptor signaling pathway involved in phagocytosis|focal adhesion|positive regulation of organelle organization|lamellipodium assembly|positive regulation of lamellipodium organization|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|cellular protein complex assembly|immune response-regulating cell surface receptor signaling pathway|regulation of actin polymerization or depolymerization|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|small GTPase binding|Fc receptor mediated stimulatory signaling pathway|endocytosis|small GTPase mediated signal transduction|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|apoptotic process|regulation of actin nucleation|protein polymerization|Ras protein signal transduction|Ras GTPase binding|actin nucleation|Fc receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|positive regulation of actin nucleation|vascular endothelial growth factor receptor signaling pathway|Rho GTPase binding|Fc-gamma receptor signaling pathway|Rac protein signal transduction|positive regulation of Arp2/3 complex-mediated actin nucleation|Arp2/3 complex-mediated actin nucleation|actin filament polymerization|regulation of Arp2/3 complex-mediated actin nucleation|Rac GTPase binding K05750 NCK-associated protein 1[-] hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) 2:182909115-183038858 3057 3755 5294 10055 9497 9981 8.63002516128421 9.63400063767181 13.4745685132403 25.4329339274372 21.997384580944 26.4070356925002 10.5795314373988 24.6124514002938 -1.21811262482202 3.22262762965076e-08 5.43857124113023e-07 DOWN ENSG00000185862 EVI2B ecotropic viral integration site 2B [Source:HGNC Symbol;Acc:HGNC:3500] GO:0005623|GO:0016020|GO:0071944|GO:0031224|GO:0005886|GO:0005887|GO:0031226|GO:0016021 cell|membrane|cell periphery|intrinsic component of membrane|plasma membrane|integral component of plasma membrane|intrinsic component of plasma membrane|integral component of membrane - - - - 17:31303766-31314112 41 52 36 14 6 6 0.806518835719414 0.92962728256719 0.638471391414891 0.246755265988789 0.0968312017406326 0.110618739993523 0.791539169900498 0.151401735907648 2.38627899821502 3.26508788359651e-08 5.50711489699945e-07 UP ENSG00000168488 ATXN2L ataxin 2-like [Source:HGNC Symbol;Acc:HGNC:31326] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:1902115|GO:0003676|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0030529|GO:0016021|GO:0022613|GO:0006996|GO:0035770|GO:0003723|GO:0010603|GO:0022618|GO:0031981|GO:0005654|GO:0070925|GO:0033043|GO:0005634|GO:0036464|GO:0034622|GO:0034063|GO:0016604|GO:0044822|GO:0033962|GO:0010494|GO:0016607 macromolecular complex|cell|membrane|cellular process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|regulation of organelle assembly|nucleic acid binding|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|integral component of membrane|ribonucleoprotein complex biogenesis|organelle organization|ribonucleoprotein granule|RNA binding|regulation of cytoplasmic mRNA processing body assembly|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|organelle assembly|regulation of organelle organization|nucleus|cytoplasmic ribonucleoprotein granule|cellular macromolecular complex assembly|stress granule assembly|nuclear body|poly(A) RNA binding|cytoplasmic mRNA processing body assembly|cytoplasmic stress granule|nuclear speck - - - - 16:28823035-28837237 4896 5176 4770 2506 2798 2485 18.9872601757017 18.2429551264514 16.6783679670275 8.70762581256184 8.90300528696297 9.03183874295489 17.9695277563935 8.88082328082657 1.01678716461666 3.2681600041033e-08 5.509184006917e-07 UP ENSG00000122257 RBBP6 retinoblastoma binding protein 6 [Source:HGNC Symbol;Acc:HGNC:9889] GO:0032502|GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0016874|GO:0048589|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0035264|GO:0048568|GO:0006139|GO:0019787|GO:0044249|GO:0019538|GO:0031323|GO:0005730|GO:0034645|GO:0046872|GO:0003723|GO:0043412|GO:0030163|GO:0004842|GO:0005815|GO:0044265|GO:0009790|GO:0036211|GO:0031981|GO:0006508|GO:0005654|GO:0006259|GO:0005694|GO:0060429|GO:0044267|GO:0009059|GO:0005856|GO:0005634|GO:0006974|GO:0044257|GO:0009792|GO:0006260|GO:0061630|GO:0061053|GO:0051603|GO:0015630|GO:0006275|GO:0046914|GO:0044822|GO:0006464|GO:0019941|GO:0043009|GO:0008270|GO:0032446|GO:0006511|GO:0001701|GO:0042787|GO:0016567 developmental process|growth|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|ligase activity|developmental growth|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|multicellular organism growth|embryonic organ development|nucleobase-containing compound metabolic process|ubiquitin-like protein transferase activity|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|nucleolus|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|microtubule organizing center|cellular macromolecule catabolic process|embryo development|protein modification process|nuclear lumen|proteolysis|nucleoplasm|DNA metabolic process|chromosome|epithelium development|cellular protein metabolic process|macromolecule biosynthetic process|cytoskeleton|nucleus|cellular response to DNA damage stimulus|cellular protein catabolic process|embryo development ending in birth or egg hatching|DNA replication|ubiquitin protein ligase activity|somite development|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|regulation of DNA replication|transition metal ion binding|poly(A) RNA binding|cellular protein modification process|modification-dependent protein catabolic process|chordate embryonic development|zinc ion binding|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|in utero embryonic development|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - 16:24537693-24572863 4965 4823 3335 1763 2181 1997 21.0847375494713 18.6142794889779 12.7690638572286 6.70809222731854 7.59928350203971 7.94796634882619 17.4893602985593 7.41844735939481 1.23728834599418 3.28314218998179e-08 5.53131641871989e-07 UP ENSG00000058085 LAMC2 laminin subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:6493] GO:0032502|GO:0031012|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0005604|GO:0005578|GO:0016043|GO:0007155|GO:0071944|GO:0005615|GO:0043256|GO:0005622|GO:0005515|GO:0043234|GO:0005605|GO:0048856|GO:0005607|GO:0009888|GO:0005938|GO:0043062|GO:0022607|GO:0005737|GO:0022617|GO:0034329|GO:0048471|GO:0060429|GO:0030198|GO:0008544|GO:0007044|GO:0031581 developmental process|extracellular matrix|macromolecular complex|cell|membrane|cellular process|extracellular region|binding|basement membrane|proteinaceous extracellular matrix|cellular component organization|cell adhesion|cell periphery|extracellular space|laminin complex|intracellular|protein binding|protein complex|basal lamina|anatomical structure development|laminin-2 complex|tissue development|cell cortex|extracellular structure organization|cellular component assembly|cytoplasm|extracellular matrix disassembly|cell junction assembly|perinuclear region of cytoplasm|epithelium development|extracellular matrix organization|epidermis development|cell-substrate junction assembly|hemidesmosome assembly K06246 laminin, gamma 2[-] hsa05200|hsa04151|hsa04510|hsa05145|hsa05146|hsa05222|hsa04512 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 1:183186238-183244900 1745 1942 2682 5103 5563 4477 16.7393272195047 16.9305835619067 23.1961300943159 43.8597177512237 43.7844184886984 40.2493335254959 18.9553469585758 42.6311565884727 -1.16930333249201 3.29150980807699e-08 5.54228617091541e-07 DOWN ENSG00000187867 PALM3 paralemmin 3 [Source:HGNC Symbol;Acc:HGNC:33274] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043167|GO:0023051|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0023057|GO:0005622|GO:0005515|GO:0005886|GO:0043168|GO:0001882|GO:0060761|GO:0005737|GO:0009966|GO:0010646|GO:0009617|GO:0007154|GO:0007165|GO:0009968|GO:0000166|GO:0010033|GO:0007166|GO:0001959|GO:0033993|GO:0035639|GO:0034097|GO:0002237|GO:0001883|GO:0032549|GO:0071310|GO:0017076|GO:0001960|GO:0032496|GO:0019221|GO:0005524|GO:0030554|GO:0008063|GO:0071345 signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|ion binding|regulation of signaling|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|negative regulation of signaling|intracellular|protein binding|plasma membrane|anion binding|nucleoside binding|negative regulation of response to cytokine stimulus|cytoplasm|regulation of signal transduction|regulation of cell communication|response to bacterium|cell communication|signal transduction|negative regulation of signal transduction|nucleotide binding|response to organic substance|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|response to lipid|purine ribonucleoside triphosphate binding|response to cytokine|response to molecule of bacterial origin|purine nucleoside binding|ribonucleoside binding|cellular response to organic substance|purine nucleotide binding|negative regulation of cytokine-mediated signaling pathway|response to lipopolysaccharide|cytokine-mediated signaling pathway|ATP binding|adenyl nucleotide binding|Toll signaling pathway|cellular response to cytokine stimulus - - - - 19:14053365-14059159 113 93 107 269 330 355 2.51281265273863 1.87951886765524 2.14526397131845 5.35960526451938 6.02094054425897 7.39842857988268 2.17919849723744 6.25965812955368 -1.52228625311122 3.38855936738115e-08 5.7024831653775e-07 DOWN ENSG00000048162 NOP16 NOP16 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:26934] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0022613|GO:0005730|GO:0003723|GO:0042254|GO:0031981|GO:0042273|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|ribosome biogenesis|nuclear lumen|ribosomal large subunit biogenesis|nucleus|poly(A) RNA binding - - - - 5:176383938-176388975 1377 1283 1052 508 618 262 13.5115348945239 11.4413510669191 9.30680749664939 4.46613720553021 4.97539386437974 2.40935654157645 11.4198978193641 3.95029587049547 1.53151712423214 3.40242095005487e-08 5.7225845094613e-07 UP ENSG00000124459 ZNF45 zinc finger protein 45 [Source:HGNC Symbol;Acc:HGNC:13111] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006352|GO:1903506|GO:0006367 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of nucleic acid-templated transcription|transcription initiation from RNA polymerase II promoter - - - - 19:43912629-43935278 481 614 391 216 199 199 3.48040107511932 4.0376907043642 2.55079625832186 1.4003493592054 1.18142224358407 1.34947680190519 3.35629601260179 1.31041613489822 1.35684493580636 3.40573430749588e-08 5.72493198288187e-07 UP ENSG00000074047 GLI2 GLI family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:4318] GO:0040011|GO:0032502|GO:0040007|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0003006|GO:0023051|GO:0009653|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0019222|GO:0007507|GO:0008284|GO:0042127|GO:1903706|GO:0048565|GO:0016337|GO:0090102|GO:0006935|GO:0045595|GO:0035239|GO:0060033|GO:0006725|GO:0061037|GO:0001822|GO:0009888|GO:0048468|GO:0050867|GO:0035295|GO:0009612|GO:1901360|GO:0048839|GO:0010941|GO:0005930|GO:0007275|GO:0030324|GO:0003676|GO:0045596|GO:0048513|GO:0070489|GO:0034641|GO:0021587|GO:0030902|GO:0030155|GO:0030900|GO:0021517|GO:0031325|GO:0046483|GO:0007420|GO:0098609|GO:0045597|GO:0043231|GO:0060740|GO:0048608|GO:0043169|GO:0005737|GO:0000981|GO:0007389|GO:0001763|GO:0007267|GO:0097546|GO:0060322|GO:0007423|GO:0060512|GO:0006928|GO:0009887|GO:0009615|GO:0002696|GO:0001775|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0072372|GO:0009890|GO:0003682|GO:0030323|GO:0060548|GO:0010646|GO:0006139|GO:0021508|GO:0021696|GO:0033504|GO:0021695|GO:0046649|GO:0050865|GO:0007154|GO:0022037|GO:0007165|GO:0007418|GO:0001503|GO:0045785|GO:0061351|GO:0097542|GO:0008219|GO:0048645|GO:0007442|GO:0030030|GO:0021549|GO:0048869|GO:0044249|GO:0030850|GO:0010033|GO:0031324|GO:0031323|GO:0021536|GO:0048732|GO:0021575|GO:0021534|GO:0000982|GO:0051249|GO:0000902|GO:0005829|GO:0031175|GO:0003677|GO:0030879|GO:0010468|GO:0034645|GO:0051216|GO:0055123|GO:0046872|GO:0042733|GO:0007166|GO:0002009|GO:0061458|GO:0030097|GO:0072358|GO:0030098|GO:0007417|GO:0001655|GO:0010629|GO:0043583|GO:0010720|GO:0043069|GO:0051252|GO:0060541|GO:0021510|GO:0034109|GO:0048754|GO:0008589|GO:0061138|GO:0022612|GO:0090103|GO:0000904|GO:0031512|GO:0009790|GO:0010628|GO:0030903|GO:0072001|GO:0001649|GO:0032330|GO:0051251|GO:0021983|GO:0042472|GO:0061525|GO:0003002|GO:0022407|GO:0021532|GO:0098586|GO:0035270|GO:0031981|GO:0016331|GO:0050769|GO:0060032|GO:0001708|GO:0007159|GO:0021514|GO:0005654|GO:0006259|GO:0042110|GO:0012501|GO:0032331|GO:0014070|GO:0060429|GO:0051054|GO:0042476|GO:0035108|GO:0010467|GO:0032990|GO:0048562|GO:0021937|GO:2000179|GO:0007399|GO:0060562|GO:0071310|GO:0097485|GO:0031328|GO:0033505|GO:0009059|GO:0030154|GO:0022409|GO:0001501|GO:0048858|GO:0061448|GO:0001228|GO:0060173|GO:0021940|GO:0061035|GO:0048566|GO:0048546|GO:2000177|GO:0016070|GO:0072359|GO:0021522|GO:0010557|GO:0005634|GO:0043067|GO:0060513|GO:0002076|GO:0051960|GO:0045165|GO:0048666|GO:0030182|GO:0002521|GO:0007411|GO:0021953|GO:0000975|GO:0060571|GO:0045893|GO:0009792|GO:0050863|GO:0006260|GO:0021904|GO:0030855|GO:0060603|GO:0021520|GO:0045892|GO:0002062|GO:0032774|GO:0048570|GO:0043565|GO:2001141|GO:0007224|GO:0021936|GO:0030217|GO:0001077|GO:0033089|GO:0045619|GO:0034112|GO:0021515|GO:1902679|GO:0008544|GO:0071407|GO:0016604|GO:0070486|GO:0003690|GO:0048663|GO:0061564|GO:0042471|GO:0033081|GO:0048665|GO:0021938|GO:0021954|GO:0009953|GO:0021521|GO:0006275|GO:0042981|GO:0009952|GO:0033077|GO:0046914|GO:0043066|GO:0042475|GO:0009954|GO:0045740|GO:0021965|GO:0021511|GO:0022008|GO:0060601|GO:0048667|GO:0050870|GO:0061180|GO:0050767|GO:0048812|GO:0060579|GO:0030326|GO:0045621|GO:0060443|GO:0006351|GO:0006915|GO:0006355|GO:1903039|GO:0045666|GO:0016607|GO:0021513|GO:0045582|GO:0045944|GO:0006366|GO:0021776|GO:1903507|GO:0021955|GO:0006357|GO:0007409|GO:0021775|GO:0048699|GO:0045580|GO:1903506|GO:0044212|GO:0060831|GO:0043009|GO:0000122|GO:0021910|GO:0021930|GO:0071593|GO:0008270|GO:0045664|GO:0009913|GO:0021952|GO:0000976|GO:0001012|GO:0001701|GO:0001159|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|growth|reproduction|immune system process|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|positive regulation of cell proliferation|regulation of cell proliferation|regulation of hemopoiesis|digestive tract development|single organismal cell-cell adhesion|cochlea development|chemotaxis|regulation of cell differentiation|tube morphogenesis|anatomical structure regression|cellular aromatic compound metabolic process|negative regulation of cartilage development|kidney development|tissue development|cell development|positive regulation of cell activation|tube development|response to mechanical stimulus|organic cyclic compound metabolic process|inner ear development|regulation of cell death|axoneme|multicellular organism development|lung development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|cerebellum morphogenesis|hindbrain development|regulation of cell adhesion|forebrain development|ventral spinal cord development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|prostate gland epithelium morphogenesis|reproductive structure development|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|morphogenesis of a branching structure|cell-cell signaling|ciliary base|head development|sensory organ development|prostate gland morphogenesis|movement of cell or subcellular component|organ morphogenesis|response to virus|positive regulation of leukocyte activation|cell activation|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|primary cilium|negative regulation of biosynthetic process|chromatin binding|respiratory tube development|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|floor plate formation|cerebellar cortex morphogenesis|floor plate development|cerebellar cortex development|lymphocyte activation|regulation of cell activation|cell communication|metencephalon development|signal transduction|ventral midline development|ossification|positive regulation of cell adhesion|neural precursor cell proliferation|ciliary tip|cell death|organ formation|hindgut morphogenesis|cell projection organization|cerebellum development|cellular developmental process|cellular biosynthetic process|prostate gland development|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|diencephalon development|gland development|hindbrain morphogenesis|cell proliferation in hindbrain|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of lymphocyte activation|cell morphogenesis|cytosol|neuron projection development|DNA binding|mammary gland development|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|digestive system development|metal ion binding|embryonic digit morphogenesis|cell surface receptor signaling pathway|morphogenesis of an epithelium|reproductive system development|hemopoiesis|cardiovascular system development|lymphocyte differentiation|central nervous system development|urogenital system development|negative regulation of gene expression|ear development|positive regulation of cell development|negative regulation of programmed cell death|regulation of RNA metabolic process|respiratory system development|spinal cord development|homotypic cell-cell adhesion|branching morphogenesis of an epithelial tube|regulation of smoothened signaling pathway|morphogenesis of a branching epithelium|gland morphogenesis|cochlea morphogenesis|cell morphogenesis involved in differentiation|motile primary cilium|embryo development|positive regulation of gene expression|notochord development|renal system development|osteoblast differentiation|regulation of chondrocyte differentiation|positive regulation of lymphocyte activation|pituitary gland development|inner ear morphogenesis|hindgut development|regionalization|regulation of cell-cell adhesion|neural tube patterning|cellular response to virus|endocrine system development|nuclear lumen|morphogenesis of embryonic epithelium|positive regulation of neurogenesis|notochord regression|cell fate specification|leukocyte cell-cell adhesion|ventral spinal cord interneuron differentiation|nucleoplasm|DNA metabolic process|T cell activation|programmed cell death|negative regulation of chondrocyte differentiation|response to organic cyclic compound|epithelium development|positive regulation of DNA metabolic process|odontogenesis|limb morphogenesis|gene expression|cell part morphogenesis|embryonic organ morphogenesis|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|positive regulation of neural precursor cell proliferation|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|neuron projection guidance|positive regulation of cellular biosynthetic process|floor plate morphogenesis|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|skeletal system development|cell projection morphogenesis|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|limb development|positive regulation of cerebellar granule cell precursor proliferation|regulation of cartilage development|embryonic digestive tract development|digestive tract morphogenesis|regulation of neural precursor cell proliferation|RNA metabolic process|circulatory system development|spinal cord motor neuron differentiation|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|prostatic bud formation|osteoblast development|regulation of nervous system development|cell fate commitment|neuron development|neuron differentiation|leukocyte differentiation|axon guidance|central nervous system neuron differentiation|regulatory region DNA binding|morphogenesis of an epithelial fold|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|regulation of T cell activation|DNA replication|dorsal/ventral neural tube patterning|epithelial cell differentiation|mammary gland duct morphogenesis|spinal cord motor neuron cell fate specification|negative regulation of transcription, DNA-templated|chondrocyte differentiation|RNA biosynthetic process|notochord morphogenesis|sequence-specific DNA binding|regulation of RNA biosynthetic process|smoothened signaling pathway|regulation of cerebellar granule cell precursor proliferation|T cell differentiation|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of T cell differentiation in thymus|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|cell differentiation in spinal cord|negative regulation of RNA biosynthetic process|epidermis development|cellular response to organic cyclic compound|nuclear body|leukocyte aggregation|double-stranded DNA binding|neuron fate commitment|axon development|ear morphogenesis|regulation of T cell differentiation in thymus|neuron fate specification|smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation|central nervous system neuron development|dorsal/ventral pattern formation|ventral spinal cord interneuron specification|regulation of DNA replication|regulation of apoptotic process|anterior/posterior pattern specification|T cell differentiation in thymus|transition metal ion binding|negative regulation of apoptotic process|odontogenesis of dentin-containing tooth|proximal/distal pattern formation|positive regulation of DNA replication|spinal cord ventral commissure morphogenesis|spinal cord patterning|neurogenesis|lateral sprouting from an epithelium|cell morphogenesis involved in neuron differentiation|positive regulation of T cell activation|mammary gland epithelium development|regulation of neurogenesis|neuron projection morphogenesis|ventral spinal cord interneuron fate commitment|embryonic limb morphogenesis|positive regulation of lymphocyte differentiation|mammary gland morphogenesis|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of leukocyte cell-cell adhesion|positive regulation of neuron differentiation|nuclear speck|spinal cord dorsal/ventral patterning|positive regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|smoothened signaling pathway involved in spinal cord motor neuron cell fate specification|negative regulation of nucleic acid-templated transcription|central nervous system neuron axonogenesis|regulation of transcription from RNA polymerase II promoter|axonogenesis|smoothened signaling pathway involved in ventral spinal cord interneuron specification|generation of neurons|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|smoothened signaling pathway involved in ventral spinal cord patterning|cerebellar granule cell precursor proliferation|lymphocyte aggregation|zinc ion binding|regulation of neuron differentiation|epidermal cell differentiation|central nervous system projection neuron axonogenesis|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K16798 zinc finger protein GLI2[-] hsa05200|hsa04390|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 2:120735623-120992653 31 37 40 92 227 157 0.11476630778335 0.124491579085332 0.133514174465631 0.305168058051638 0.689519902101457 0.544732393497638 0.124257353778104 0.513140117883578 -2.04602158584055 3.41763573412856e-08 5.74170496379708e-07 DOWN ENSG00000279041 CTD-2373N4.3 - - - - - - - 8:30552345-30553766 4 2 5 26 33 26 0.198969234734642 0.090418146384064 0.224231283970955 1.15881719378738 1.34688664655314 1.21212442339794 0.171206221696554 1.23927608791282 -2.8556905933302 3.45170089425182e-08 5.79567370624263e-07 DOWN ENSG00000257949 TEN1 TEN1 CST complex subunit [Source:HGNC Symbol;Acc:HGNC:37242] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0030234|GO:0032993|GO:0005622|GO:0005515|GO:0019222|GO:0004857|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0032204|GO:0046483|GO:0051128|GO:0043231|GO:0000723|GO:0042592|GO:0009890|GO:0006139|GO:0044092|GO:0050790|GO:0043086|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0034645|GO:0051053|GO:0010833|GO:0031981|GO:0010521|GO:0006259|GO:0005694|GO:0000228|GO:0033043|GO:1904356|GO:0009059|GO:0005634|GO:0000783|GO:0008156|GO:0032200|GO:0006260|GO:0000781|GO:2000279|GO:0051972|GO:0003697|GO:0043565|GO:0033044|GO:2000278|GO:1990879|GO:0006275|GO:0000784|GO:0071897|GO:0051974|GO:0042162 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|enzyme regulator activity|protein-DNA complex|intracellular|protein binding|regulation of metabolic process|enzyme inhibitor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|regulation of telomere maintenance|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|telomere maintenance|homeostatic process|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|telomere maintenance via telomere lengthening|nuclear lumen|telomerase inhibitor activity|DNA metabolic process|chromosome|nuclear chromosome|regulation of organelle organization|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|nucleus|nuclear telomere cap complex|negative regulation of DNA replication|telomere organization|DNA replication|chromosome, telomeric region|negative regulation of DNA biosynthetic process|regulation of telomerase activity|single-stranded DNA binding|sequence-specific DNA binding|regulation of chromosome organization|regulation of DNA biosynthetic process|CST complex|regulation of DNA replication|nuclear chromosome, telomeric region|DNA biosynthetic process|negative regulation of telomerase activity|telomeric DNA binding - - - - 17:75979220-76000586 53 43 36 188 162 144 1.27735757704429 0.941868624891945 0.782263415171362 4.05969866467211 3.20346656703229 3.25258811555306 1.00049653903587 3.50525111575249 -1.80880162581637 3.4780967815208e-08 5.8367117096977e-07 DOWN ENSG00000112651 MRPL2 mitochondrial ribosomal protein L2 [Source:HGNC Symbol;Acc:HGNC:14056] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0016740|GO:0031090|GO:0019866|GO:0003676|GO:0034641|GO:0005761|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0031966|GO:0044249|GO:0019538|GO:0006996|GO:0005740|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0005840|GO:0005743|GO:0005759|GO:0005739|GO:0015934|GO:0070124|GO:0043603|GO:0044267|GO:0010467|GO:0005762|GO:0009059|GO:0032543|GO:0043241|GO:0043043|GO:0070125|GO:0006412|GO:0044822|GO:0070126|GO:0006414|GO:0043624|GO:0006415 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|transferase activity|organelle membrane|organelle inner membrane|nucleic acid binding|cellular nitrogen compound metabolic process|mitochondrial ribosome|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|cellular biosynthetic process|protein metabolic process|organelle organization|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|ribosome|mitochondrial inner membrane|mitochondrial matrix|mitochondrion|large ribosomal subunit|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|mitochondrial large ribosomal subunit|macromolecule biosynthetic process|mitochondrial translation|protein complex disassembly|peptide biosynthetic process|mitochondrial translational elongation|translation|poly(A) RNA binding|mitochondrial translational termination|translational elongation|cellular protein complex disassembly|translational termination K02886 large subunit ribosomal protein L2[-] hsa03010 Ribosome - Homo sapiens (human) 6:43054029-43059806 1173 1216 1176 632 670 511 15.2190655912891 14.3384961531144 13.7566128844235 7.34690982484714 7.1323487548926 6.21354491801872 14.438058209609 6.89760116591949 1.06571010901828 3.50800570144149e-08 5.88359562982214e-07 UP ENSG00000084112 SSH1 slingshot protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:30579] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0030496|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0009986|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0045595|GO:0048468|GO:0007275|GO:0003676|GO:0032535|GO:0016788|GO:0051128|GO:0022607|GO:0043231|GO:0010243|GO:0005737|GO:0032970|GO:0030027|GO:0060491|GO:0008092|GO:0030030|GO:0048869|GO:0016021|GO:0030029|GO:0019538|GO:0010033|GO:0031323|GO:0032154|GO:0006996|GO:0032268|GO:0000902|GO:0031175|GO:0003677|GO:0031344|GO:0032956|GO:0014074|GO:0043412|GO:0007010|GO:0046683|GO:0003779|GO:0000904|GO:0071417|GO:0036211|GO:0031981|GO:0030031|GO:0005654|GO:0022604|GO:0033198|GO:0030036|GO:0014070|GO:0097581|GO:0006796|GO:0033043|GO:0044267|GO:0010591|GO:0032990|GO:0007399|GO:0071310|GO:0051246|GO:0030154|GO:0030832|GO:0048858|GO:0005856|GO:0005634|GO:0042578|GO:0051960|GO:0048666|GO:0030182|GO:0016311|GO:0010975|GO:0030032|GO:0010769|GO:0071318|GO:0071407|GO:0008064|GO:0061564|GO:0051493|GO:0016791|GO:0022008|GO:0048667|GO:0006464|GO:0007015|GO:0050767|GO:0048812|GO:0006470|GO:0007409|GO:0048699|GO:0004721|GO:0050770|GO:0045664|GO:0008154|GO:0035335|GO:0008138|GO:0004725 developmental process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|midbody|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|cell surface|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cell development|multicellular organism development|nucleic acid binding|regulation of cellular component size|hydrolase activity, acting on ester bonds|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|lamellipodium|regulation of cell projection assembly|cytoskeletal protein binding|cell projection organization|cellular developmental process|integral component of membrane|actin filament-based process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|cleavage furrow|organelle organization|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|DNA binding|regulation of cell projection organization|regulation of actin cytoskeleton organization|response to purine-containing compound|macromolecule modification|cytoskeleton organization|response to organophosphorus|actin binding|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|protein modification process|nuclear lumen|cell projection assembly|nucleoplasm|regulation of cell morphogenesis|response to ATP|actin cytoskeleton organization|response to organic cyclic compound|lamellipodium organization|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of lamellipodium assembly|cell part morphogenesis|nervous system development|cellular response to organic substance|regulation of protein metabolic process|cell differentiation|regulation of actin filament length|cell projection morphogenesis|cytoskeleton|nucleus|phosphoric ester hydrolase activity|regulation of nervous system development|neuron development|neuron differentiation|dephosphorylation|regulation of neuron projection development|lamellipodium assembly|regulation of cell morphogenesis involved in differentiation|cellular response to ATP|cellular response to organic cyclic compound|regulation of actin polymerization or depolymerization|axon development|regulation of cytoskeleton organization|phosphatase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|actin filament organization|regulation of neurogenesis|neuron projection morphogenesis|protein dephosphorylation|axonogenesis|generation of neurons|phosphoprotein phosphatase activity|regulation of axonogenesis|regulation of neuron differentiation|actin polymerization or depolymerization|peptidyl-tyrosine dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity K05766 protein phosphatase slingshot[3.1.3.48] hsa04810|hsa04360 Regulation of actin cytoskeleton - Homo sapiens (human)|Axon guidance - Homo sapiens (human) 12:108778192-108857590 1570 2076 2162 940 1068 1040 5.17916626323897 6.22397153682299 6.43028233016802 2.77834322556784 2.89067720186444 3.21530796778092 5.94447337674333 2.9614427984044 1.00524878660503 3.51076619067044e-08 5.88491936306992e-07 UP ENSG00000043355 ZIC2 Zic family member 2 [Source:HGNC Symbol;Acc:HGNC:12873] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0031325|GO:0046483|GO:0007420|GO:0043231|GO:0043169|GO:0005737|GO:0060322|GO:0009890|GO:0003682|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0051090|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0007417|GO:0010629|GO:0051252|GO:0010628|GO:0051091|GO:0007600|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0031490|GO:0045893|GO:0050953|GO:0043566|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:1903507|GO:1903506|GO:0007601 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|cation binding|cytoplasm|head development|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|central nervous system development|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|positive regulation of sequence-specific DNA binding transcription factor activity|sensory perception|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|chromatin DNA binding|positive regulation of transcription, DNA-templated|sensory perception of light stimulus|structure-specific DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|visual perception K06235 zinc finger protein ZIC 2[-] hsa04340 Hedgehog signaling pathway - Homo sapiens (human) 13:99981772-99986773 312 281 186 78 109 70 4.05249092068692 3.31706983269857 2.17818287359898 0.90773304236081 1.16161588382199 0.852105455461528 3.18258120899482 0.973818127214776 1.70847306629324 3.60690773959906e-08 6.04268370695793e-07 UP ENSG00000112245 PTP4A1 protein tyrosine phosphatase type IVA, member 1 [Source:HGNC Symbol;Acc:HGNC:9634] GO:0040011|GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0050794|GO:0040012|GO:0043229|GO:0071704|GO:0044237|GO:0048870|GO:0040017|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005886|GO:0012505|GO:0048856|GO:0051272|GO:0007049|GO:0009898|GO:0007275|GO:0016788|GO:0031982|GO:2000147|GO:0043231|GO:0005737|GO:0006928|GO:0098562|GO:0051270|GO:0016477|GO:0005783|GO:0070062|GO:2000145|GO:0019538|GO:0005768|GO:0043412|GO:0005769|GO:0030334|GO:0036211|GO:0006796|GO:0044267|GO:0030335|GO:0005856|GO:0005634|GO:0042578|GO:0005819|GO:0016311|GO:0015630|GO:0016791|GO:0006464|GO:0006470|GO:0004721|GO:0035335|GO:0008138|GO:0004725 locomotion|developmental process|cell|membrane|cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|regulation of cellular process|regulation of locomotion|intracellular organelle|organic substance metabolic process|cellular metabolic process|cell motility|positive regulation of locomotion|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|plasma membrane|endomembrane system|anatomical structure development|positive regulation of cellular component movement|cell cycle|cytoplasmic side of plasma membrane|multicellular organism development|hydrolase activity, acting on ester bonds|vesicle|positive regulation of cell motility|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|cytoplasmic side of membrane|regulation of cellular component movement|cell migration|endoplasmic reticulum|extracellular exosome|regulation of cell motility|protein metabolic process|endosome|macromolecule modification|early endosome|regulation of cell migration|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|positive regulation of cell migration|cytoskeleton|nucleus|phosphoric ester hydrolase activity|spindle|dephosphorylation|microtubule cytoskeleton|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|peptidyl-tyrosine dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity - - - - 6:63521761-63583587 3963 3423 3078 1545 2020 1247 33.1085544159722 25.9898085317793 23.184572005551 11.5649126242635 13.8463559732457 9.76363416184286 27.4276449844342 11.7249675864507 1.22604681917574 3.63072222954774e-08 6.07576129153129e-07 UP ENSG00000156735 BAG4 BCL2 associated athanogene 4 [Source:HGNC Symbol;Acc:HGNC:940] GO:0040011|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0044089|GO:0005057|GO:0071704|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0016043|GO:0006457|GO:0007155|GO:0043227|GO:0071944|GO:1903828|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0060341|GO:0051272|GO:0006810|GO:0070849|GO:0051130|GO:0010941|GO:0003676|GO:0032535|GO:0030155|GO:0031325|GO:0051128|GO:2000147|GO:0033554|GO:0022607|GO:0043231|GO:0051087|GO:0019899|GO:1903748|GO:0005737|GO:0032970|GO:0032880|GO:0009408|GO:0006928|GO:0009966|GO:0045184|GO:0060548|GO:0032231|GO:0032387|GO:0010646|GO:0008104|GO:0007154|GO:0044092|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0032233|GO:0051649|GO:0045785|GO:0008219|GO:0090317|GO:0050790|GO:0030030|GO:0043086|GO:0030029|GO:2000145|GO:0009967|GO:0009266|GO:0019538|GO:0031334|GO:0043254|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:0010256|GO:0006996|GO:1900034|GO:0051017|GO:1902533|GO:0032268|GO:0005829|GO:0003723|GO:0007166|GO:0032956|GO:0043412|GO:0072594|GO:0007010|GO:0034097|GO:0007005|GO:0043069|GO:0032386|GO:0051223|GO:0015031|GO:0030334|GO:0001667|GO:0007009|GO:0036211|GO:0032269|GO:0070201|GO:0046907|GO:1903215|GO:0071364|GO:0072657|GO:0030031|GO:0034605|GO:0051247|GO:0051346|GO:0070848|GO:0006461|GO:0030036|GO:0034613|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0032273|GO:0033043|GO:0044267|GO:0051174|GO:0071310|GO:0006626|GO:0051246|GO:0031529|GO:0030832|GO:0030335|GO:0051496|GO:1903827|GO:1902531|GO:0005634|GO:0051492|GO:0043067|GO:0044389|GO:0010638|GO:0031625|GO:0051896|GO:0043491|GO:0010923|GO:0016311|GO:0019221|GO:0033365|GO:0033157|GO:0031401|GO:0034622|GO:0030838|GO:0072659|GO:0006839|GO:0010763|GO:0043623|GO:0071363|GO:0016310|GO:0051897|GO:0006605|GO:0072655|GO:0010823|GO:0008064|GO:0016482|GO:0006886|GO:0051493|GO:0010821|GO:0010762|GO:0042981|GO:0071345|GO:0043066|GO:0044822|GO:0097178|GO:0034612|GO:0031032|GO:0030038|GO:0006464|GO:0007015|GO:0051495|GO:1903214|GO:1990778|GO:0010761|GO:0030833|GO:0006915|GO:0010921|GO:0006470|GO:0035304|GO:1903533|GO:0051258|GO:0006468|GO:0071356|GO:0042325|GO:0001932|GO:2001145|GO:0018193|GO:0043149|GO:0033209|GO:0001934|GO:0035305|GO:0061572|GO:0042327|GO:0035303|GO:0070585|GO:0035308|GO:0008154|GO:0033138|GO:0018105|GO:0033135|GO:0030041 locomotion|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|positive regulation of cellular component biogenesis|receptor signaling protein activity|organic substance metabolic process|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|cellular component organization|protein folding|cell adhesion|membrane-bounded organelle|cell periphery|negative regulation of cellular protein localization|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|regulation of cellular localization|positive regulation of cellular component movement|transport|response to epidermal growth factor|positive regulation of cellular component organization|regulation of cell death|nucleic acid binding|regulation of cellular component size|regulation of cell adhesion|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|chaperone binding|enzyme binding|negative regulation of establishment of protein localization to mitochondrion|cytoplasm|regulation of actin filament-based process|regulation of protein localization|response to heat|movement of cell or subcellular component|regulation of signal transduction|establishment of protein localization|negative regulation of cell death|regulation of actin filament bundle assembly|negative regulation of intracellular transport|regulation of cell communication|protein localization|cell communication|negative regulation of molecular function|membrane organization|regulation of cellular component movement|cell migration|signal transduction|positive regulation of actin filament bundle assembly|establishment of localization in cell|positive regulation of cell adhesion|cell death|negative regulation of intracellular protein transport|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|actin filament-based process|regulation of cell motility|positive regulation of signal transduction|response to temperature stimulus|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endomembrane system organization|organelle organization|regulation of cellular response to heat|actin filament bundle assembly|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|RNA binding|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|macromolecule modification|establishment of protein localization to organelle|cytoskeleton organization|response to cytokine|mitochondrion organization|negative regulation of programmed cell death|regulation of intracellular transport|regulation of protein transport|protein transport|regulation of cell migration|ameboidal-type cell migration|plasma membrane organization|protein modification process|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|intracellular transport|negative regulation of protein targeting to mitochondrion|cellular response to epidermal growth factor stimulus|protein localization to membrane|cell projection assembly|cellular response to heat|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|protein complex assembly|actin cytoskeleton organization|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|positive regulation of protein polymerization|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|protein targeting to mitochondrion|regulation of protein metabolic process|ruffle organization|regulation of actin filament length|positive regulation of cell migration|positive regulation of stress fiber assembly|regulation of cellular protein localization|regulation of intracellular signal transduction|nucleus|regulation of stress fiber assembly|regulation of programmed cell death|ubiquitin-like protein ligase binding|positive regulation of organelle organization|ubiquitin protein ligase binding|regulation of protein kinase B signaling|protein kinase B signaling|negative regulation of phosphatase activity|dephosphorylation|cytokine-mediated signaling pathway|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|protein localization to plasma membrane|mitochondrial transport|positive regulation of fibroblast migration|cellular protein complex assembly|cellular response to growth factor stimulus|phosphorylation|positive regulation of protein kinase B signaling|protein targeting|establishment of protein localization to mitochondrion|negative regulation of mitochondrion organization|regulation of actin polymerization or depolymerization|cytosolic transport|intracellular protein transport|regulation of cytoskeleton organization|regulation of mitochondrion organization|regulation of fibroblast migration|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|poly(A) RNA binding|ruffle assembly|response to tumor necrosis factor|actomyosin structure organization|contractile actin filament bundle assembly|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|regulation of protein targeting to mitochondrion|protein localization to cell periphery|fibroblast migration|regulation of actin filament polymerization|apoptotic process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|regulation of protein targeting|protein polymerization|protein phosphorylation|cellular response to tumor necrosis factor|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity|peptidyl-amino acid modification|stress fiber assembly|tumor necrosis factor-mediated signaling pathway|positive regulation of protein phosphorylation|negative regulation of dephosphorylation|actin filament bundle organization|positive regulation of phosphorylation|regulation of dephosphorylation|protein localization to mitochondrion|negative regulation of protein dephosphorylation|actin polymerization or depolymerization|positive regulation of peptidyl-serine phosphorylation|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|actin filament polymerization K09558 BCL2-associated athanogene 4[-] hsa04668 TNF signaling pathway - Homo sapiens (human) 8:38176533-38213301 630 700 725 363 382 309 6.3418526749338 6.40403761273152 6.58003694342207 3.27400711806325 3.15505378036839 2.91516065529093 6.4419757436958 3.11474051790752 1.04839124793081 3.63000393366508e-08 6.07576129153129e-07 UP ENSG00000227124 ZNF717 zinc finger protein 717 [Source:HGNC Symbol;Acc:HGNC:29448] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 3:75709643-75785583 14 10 27 66 77 103 0.129795038299241 0.084255966027614 0.22568466968996 0.548231721576278 0.585707800718262 0.894925029477036 0.146578558005605 0.676288183923859 -2.20596407055704 3.63536041697377e-08 6.08011483968263e-07 DOWN ENSG00000128512 DOCK4 dedicator of cytokinesis 4 [Source:HGNC Symbol;Acc:HGNC:19192] GO:0040011|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0040012|GO:0032420|GO:0048870|GO:0040017|GO:0009605|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0005085|GO:0019222|GO:0051272|GO:0006935|GO:0032421|GO:0005102|GO:0008047|GO:2000147|GO:0019899|GO:0005737|GO:0003012|GO:0006928|GO:0019904|GO:0043085|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0045932|GO:0050790|GO:2000145|GO:0003013|GO:0005829|GO:0035150|GO:0006936|GO:0005096|GO:0051345|GO:0030695|GO:0017124|GO:0030165|GO:0090257|GO:0030334|GO:0030971|GO:0045906|GO:0060326|GO:0019900|GO:0035556|GO:0045986|GO:0051020|GO:0030335|GO:0008015|GO:0006939|GO:0006937|GO:1904694|GO:0014909|GO:0043087|GO:0014910|GO:0019229|GO:0043547|GO:0014911|GO:0031267|GO:0019901|GO:0007264|GO:0050880|GO:0003056|GO:0006940|GO:0017016|GO:0014829|GO:0042310|GO:1990782|GO:0017048|GO:0048365 locomotion|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|regulation of locomotion|stereocilium|cell motility|positive regulation of locomotion|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|regulation of metabolic process|positive regulation of cellular component movement|chemotaxis|stereocilium bundle|receptor binding|enzyme activator activity|positive regulation of cell motility|enzyme binding|cytoplasm|muscle system process|movement of cell or subcellular component|protein domain specific binding|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of muscle contraction|regulation of catalytic activity|regulation of cell motility|circulatory system process|cytosol|regulation of tube size|muscle contraction|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|SH3 domain binding|PDZ domain binding|regulation of muscle system process|regulation of cell migration|receptor tyrosine kinase binding|negative regulation of vasoconstriction|cell chemotaxis|kinase binding|intracellular signal transduction|negative regulation of smooth muscle contraction|GTPase binding|positive regulation of cell migration|blood circulation|smooth muscle contraction|regulation of muscle contraction|negative regulation of vascular smooth muscle contraction|smooth muscle cell migration|regulation of GTPase activity|regulation of smooth muscle cell migration|regulation of vasoconstriction|positive regulation of GTPase activity|positive regulation of smooth muscle cell migration|small GTPase binding|protein kinase binding|small GTPase mediated signal transduction|regulation of blood vessel size|regulation of vascular smooth muscle contraction|regulation of smooth muscle contraction|Ras GTPase binding|vascular smooth muscle contraction|vasoconstriction|protein tyrosine kinase binding|Rho GTPase binding|Rac GTPase binding K17697 dedicator of cytokinesis protein 4[-] hsa04015 Rap1 signaling pathway - Homo sapiens (human) 7:111726110-112206411 3 4 17 38 73 64 0.01021238664801 0.0123736506744432 0.0521698349421259 0.115889148342204 0.20386939908771 0.204159938320526 0.024918624088193 0.174639495250147 -2.80908355018267 3.64232609074136e-08 6.08835403768155e-07 DOWN ENSG00000198355 PIM3 Pim-3 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:19310] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0071704|GO:0043167|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0023057|GO:0005622|GO:0005515|GO:0016740|GO:0060341|GO:0051726|GO:0007049|GO:0061179|GO:0006810|GO:0010941|GO:0061178|GO:0043168|GO:0032940|GO:0001882|GO:0016772|GO:0005737|GO:0007267|GO:0032880|GO:0042592|GO:0045184|GO:0046883|GO:0019725|GO:0060548|GO:0010646|GO:0008104|GO:0007154|GO:0051649|GO:0046888|GO:0008219|GO:0051048|GO:1903531|GO:0000166|GO:0010817|GO:0019538|GO:0010033|GO:0051224|GO:0009743|GO:0090276|GO:0035639|GO:0043412|GO:0043069|GO:0048878|GO:0050709|GO:0001883|GO:0051223|GO:0015031|GO:0036211|GO:0000278|GO:0070201|GO:0042886|GO:0032549|GO:0055082|GO:0051046|GO:0007346|GO:0009914|GO:0009306|GO:0016301|GO:0035773|GO:0012501|GO:0006796|GO:0002792|GO:0044267|GO:0046903|GO:0071310|GO:0017076|GO:0016773|GO:0043067|GO:0050796|GO:0071322|GO:0002790|GO:0030073|GO:0001678|GO:0046676|GO:0005524|GO:0034284|GO:0050708|GO:0030554|GO:0016310|GO:0015833|GO:0042981|GO:0043066|GO:0004672|GO:0006464|GO:0046879|GO:0006915|GO:0033500|GO:0071333|GO:0042593|GO:0030072|GO:0006468|GO:0004674|GO:0046777|GO:0009749 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|ion binding|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|negative regulation of signaling|intracellular|protein binding|transferase activity|regulation of cellular localization|regulation of cell cycle|cell cycle|negative regulation of insulin secretion involved in cellular response to glucose stimulus|transport|regulation of cell death|regulation of insulin secretion involved in cellular response to glucose stimulus|anion binding|secretion by cell|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cytoplasm|cell-cell signaling|regulation of protein localization|homeostatic process|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|negative regulation of cell death|regulation of cell communication|protein localization|cell communication|establishment of localization in cell|negative regulation of hormone secretion|cell death|negative regulation of secretion|negative regulation of secretion by cell|nucleotide binding|regulation of hormone levels|protein metabolic process|response to organic substance|negative regulation of protein transport|response to carbohydrate|regulation of peptide hormone secretion|purine ribonucleoside triphosphate binding|macromolecule modification|negative regulation of programmed cell death|chemical homeostasis|negative regulation of protein secretion|purine nucleoside binding|regulation of protein transport|protein transport|protein modification process|mitotic cell cycle|regulation of establishment of protein localization|amide transport|ribonucleoside binding|cellular chemical homeostasis|regulation of secretion|regulation of mitotic cell cycle|hormone transport|protein secretion|kinase activity|insulin secretion involved in cellular response to glucose stimulus|programmed cell death|phosphate-containing compound metabolic process|negative regulation of peptide secretion|cellular protein metabolic process|secretion|cellular response to organic substance|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|regulation of programmed cell death|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|insulin secretion|cellular glucose homeostasis|negative regulation of insulin secretion|ATP binding|response to monosaccharide|regulation of protein secretion|adenyl nucleotide binding|phosphorylation|peptide transport|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|cellular protein modification process|hormone secretion|apoptotic process|carbohydrate homeostasis|cellular response to glucose stimulus|glucose homeostasis|peptide hormone secretion|protein phosphorylation|protein serine/threonine kinase activity|protein autophosphorylation|response to glucose - - - - 22:49960513-49964080 2856 2950 3489 1396 1680 1786 66.4335629183502 62.3636252977698 73.1719334705475 29.0945927928889 32.0631839806262 38.9349622752184 67.3230405622225 33.3642463495778 1.01279741987484 3.65968579879179e-08 6.11394850795356e-07 UP ENSG00000186106 ANKRD46 ankyrin repeat domain 46 [Source:HGNC Symbol;Acc:HGNC:27229] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 8:100509752-100559784 706 704 883 344 401 423 4.78492043447504 4.33633434061327 5.39566779951065 2.08894394906761 2.22988399616364 2.68682534562564 4.83897419153299 2.33521776361896 1.05114415434202 3.6758934322415e-08 6.13759074530971e-07 UP ENSG00000139132 FGD4 FYVE, RhoGEF and PH domain containing 4 [Source:HGNC Symbol;Acc:HGNC:19125] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0043167|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0031252|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0005085|GO:0048856|GO:0019222|GO:0008360|GO:0010941|GO:0051128|GO:0022607|GO:0010942|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0001726|GO:0005088|GO:0009966|GO:0030027|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008092|GO:0008219|GO:0050790|GO:0030030|GO:0048869|GO:0030029|GO:0010033|GO:0005794|GO:0006996|GO:0000902|GO:0005829|GO:0046872|GO:0007166|GO:0007010|GO:0051345|GO:0003779|GO:0030031|GO:0070848|GO:0022604|GO:0030175|GO:0030036|GO:0012501|GO:0097581|GO:0035556|GO:0071310|GO:0051020|GO:0005089|GO:0043068|GO:1902531|GO:0005856|GO:0043067|GO:0097190|GO:0015629|GO:0030032|GO:0043065|GO:0071363|GO:0043087|GO:0038179|GO:0043547|GO:0007167|GO:0046847|GO:0031267|GO:0042981|GO:0051056|GO:0007264|GO:0030035|GO:0006915|GO:0048011|GO:0007265|GO:0046578|GO:0007169|GO:0035023|GO:0007266 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|ion binding|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|cell leading edge|regulation of developmental process|intracellular|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|regulation of cell shape|regulation of cell death|regulation of cellular component organization|cellular component assembly|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|ruffle|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|lamellipodium|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cytoskeletal protein binding|cell death|regulation of catalytic activity|cell projection organization|cellular developmental process|actin filament-based process|response to organic substance|Golgi apparatus|organelle organization|cell morphogenesis|cytosol|metal ion binding|cell surface receptor signaling pathway|cytoskeleton organization|positive regulation of hydrolase activity|actin binding|cell projection assembly|response to growth factor|regulation of cell morphogenesis|filopodium|actin cytoskeleton organization|programmed cell death|lamellipodium organization|intracellular signal transduction|cellular response to organic substance|GTPase binding|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|cytoskeleton|regulation of programmed cell death|apoptotic signaling pathway|actin cytoskeleton|lamellipodium assembly|positive regulation of apoptotic process|cellular response to growth factor stimulus|regulation of GTPase activity|neurotrophin signaling pathway|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|filopodium assembly|small GTPase binding|regulation of apoptotic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|microspike assembly|apoptotic process|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction - - - - 12:32399529-32646050 42 75 113 263 276 257 0.167480814348088 0.271806645278092 0.406266024282332 0.939659463937941 0.903012253946571 0.96045730112101 0.281851161302837 0.934376339668507 -1.72907023088931 3.70314398315485e-08 6.17963445908915e-07 DOWN ENSG00000156675 RAB11FIP1 RAB11 family interacting protein 1 (class I) [Source:HGNC Symbol;Acc:HGNC:30265] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0051051|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0060341|GO:0070164|GO:0006810|GO:0032940|GO:0031982|GO:0043231|GO:0019899|GO:0005737|GO:0007267|GO:0032880|GO:0012506|GO:0030666|GO:0045184|GO:0046883|GO:0010646|GO:0008104|GO:0007154|GO:0046888|GO:0051048|GO:1903531|GO:0010817|GO:0051224|GO:0005768|GO:0016192|GO:0031410|GO:0050709|GO:0051223|GO:0015031|GO:0016023|GO:0006887|GO:0070201|GO:0055037|GO:0051046|GO:0009914|GO:0009306|GO:0031988|GO:0030659|GO:0046903|GO:0051020|GO:0030670|GO:0045055|GO:0030139|GO:0050708|GO:0031267|GO:0046879|GO:0017016|GO:0045335|GO:0017137 signaling|cell|membrane|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|negative regulation of transport|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|intracellular|protein binding|endomembrane system|organelle membrane|regulation of cellular localization|negative regulation of adiponectin secretion|transport|secretion by cell|vesicle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|cell-cell signaling|regulation of protein localization|vesicle membrane|endocytic vesicle membrane|establishment of protein localization|regulation of hormone secretion|regulation of cell communication|protein localization|cell communication|negative regulation of hormone secretion|negative regulation of secretion|negative regulation of secretion by cell|regulation of hormone levels|negative regulation of protein transport|endosome|vesicle-mediated transport|cytoplasmic vesicle|negative regulation of protein secretion|regulation of protein transport|protein transport|cytoplasmic, membrane-bounded vesicle|exocytosis|regulation of establishment of protein localization|recycling endosome|regulation of secretion|hormone transport|protein secretion|membrane-bounded vesicle|cytoplasmic vesicle membrane|secretion|GTPase binding|phagocytic vesicle membrane|regulated exocytosis|endocytic vesicle|regulation of protein secretion|small GTPase binding|hormone secretion|Ras GTPase binding|phagocytic vesicle|Rab GTPase binding K12484 Rab11 family-interacting protein 1/2/5[-] hsa04144 Endocytosis - Homo sapiens (human) 8:37858618-37899467 2966 3177 4360 1504 1616 2035 10.7924633777647 10.5062259530414 14.3037601791907 4.90337430092989 4.82457125494378 6.93973332632473 11.8674831699989 5.5558929607328 1.09492329391089 3.71571621701654e-08 6.19715038786658e-07 UP ENSG00000065548 ZC3H15 zinc finger CCCH-type containing 15 [Source:HGNC Symbol;Acc:HGNC:29528] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0010033|GO:0005730|GO:0046872|GO:0003723|GO:0007166|GO:0034097|GO:0031981|GO:0071310|GO:0005634|GO:0019221|GO:0071345|GO:0044822 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell communication|signal transduction|response to organic substance|nucleolus|metal ion binding|RNA binding|cell surface receptor signaling pathway|response to cytokine|nuclear lumen|cellular response to organic substance|nucleus|cytokine-mediated signaling pathway|cellular response to cytokine stimulus|poly(A) RNA binding - - - - 2:186486156-186509363 4563 4484 3339 2040 2111 1545 62.0357977777056 55.4035417294718 40.9281969782516 24.849621233812 23.5476807616834 19.6856257269167 52.7891788284763 22.694309240804 1.21791164724192 3.72802691820527e-08 6.21421081050252e-07 UP ENSG00000146676 PURB purine-rich element binding protein B [Source:HGNC Symbol;Acc:HGNC:9702] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0032993|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:1903706|GO:0045595|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0046332|GO:0000981|GO:0009890|GO:0006139|GO:0008134|GO:0005662|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0003723|GO:0030097|GO:0010629|GO:0051252|GO:0005657|GO:0031981|GO:0005694|GO:0000228|GO:0010467|GO:0001227|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0045637|GO:0000975|GO:0043596|GO:0045892|GO:0003697|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0044822|GO:0030099|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0003729|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0000977 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|protein-DNA complex|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|regulation of hemopoiesis|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|SMAD binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|transcription factor binding|DNA replication factor A complex|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|hemopoiesis|negative regulation of gene expression|regulation of RNA metabolic process|replication fork|nuclear lumen|chromosome|nuclear chromosome|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|regulation of myeloid cell differentiation|regulatory region DNA binding|nuclear replication fork|negative regulation of transcription, DNA-templated|single-stranded DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|poly(A) RNA binding|myeloid cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|mRNA binding|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 7:44876293-44885361 838 1046 1139 2105 2387 2703 6.5362783890634 7.41477327423337 8.00984660890673 14.7107921935647 15.2758978250961 19.758833895617 7.32029942406783 16.5818413047593 -1.17962965180359 3.76163624789027e-08 6.26673485181452e-07 DOWN ENSG00000142892 PIGK phosphatidylinositol glycan anchor biosynthesis class K [Source:HGNC Symbol;Acc:HGNC:8965] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0006457|GO:0043227|GO:0008289|GO:0016853|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0044255|GO:0003923|GO:0043168|GO:0005543|GO:0019637|GO:0043231|GO:0031227|GO:0008233|GO:0005737|GO:0016860|GO:0030176|GO:0008104|GO:0042765|GO:0006629|GO:0005783|GO:0051861|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0008654|GO:0034645|GO:0046486|GO:0043412|GO:0034235|GO:0035091|GO:0006643|GO:0036211|GO:0042157|GO:0006508|GO:0034613|GO:0006796|GO:1901137|GO:0044267|GO:0008610|GO:0009059|GO:0006644|GO:0046474|GO:0009247|GO:0034394|GO:0006664|GO:0042158|GO:0008234|GO:0003756|GO:0006464|GO:0006650|GO:0006506|GO:0046488|GO:0006661|GO:0006505|GO:0016255|GO:0043687|GO:0006497|GO:0006501 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|protein folding|membrane-bounded organelle|lipid binding|isomerase activity|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|cellular lipid metabolic process|GPI-anchor transamidase activity|anion binding|phospholipid binding|organophosphate metabolic process|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|peptidase activity|cytoplasm|intramolecular oxidoreductase activity|integral component of endoplasmic reticulum membrane|protein localization|GPI-anchor transamidase complex|lipid metabolic process|endoplasmic reticulum|glycolipid binding|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|glycerolipid metabolic process|macromolecule modification|GPI anchor binding|phosphatidylinositol binding|membrane lipid metabolic process|protein modification process|lipoprotein metabolic process|proteolysis|cellular protein localization|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|lipid biosynthetic process|macromolecule biosynthetic process|phospholipid metabolic process|glycerophospholipid biosynthetic process|glycolipid biosynthetic process|protein localization to cell surface|glycolipid metabolic process|lipoprotein biosynthetic process|cysteine-type peptidase activity|protein disulfide isomerase activity|cellular protein modification process|glycerophospholipid metabolic process|GPI anchor biosynthetic process|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|GPI anchor metabolic process|attachment of GPI anchor to protein|post-translational protein modification|protein lipidation|C-terminal protein lipidation K05290 phosphatidylinositol glycan, class K [EC:2.6.-.-][-] hsa01100|hsa00563 Metabolic pathways - Homo sapiens (human)|Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human) 1:77088990-77219430 396 410 424 911 1078 912 4.37684627288302 4.11841479714597 4.22518122104928 9.02156267489985 9.77580201698093 9.44690868648786 4.24014743035942 9.41475779278955 -1.1508095517468 3.77435757378376e-08 6.28442113818964e-07 DOWN ENSG00000196975 ANXA4 annexin A4 [Source:HGNC Symbol;Acc:HGNC:542] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0009986|GO:0051051|GO:0044237|GO:0051641|GO:0043227|GO:0008289|GO:0071944|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0060341|GO:0001818|GO:0050817|GO:0004857|GO:0006725|GO:0009888|GO:0006810|GO:1901360|GO:0010941|GO:0034641|GO:0043168|GO:0032940|GO:0005543|GO:0031982|GO:0046483|GO:0001817|GO:0043231|GO:0043169|GO:0005737|GO:0001816|GO:0032880|GO:0012506|GO:0005635|GO:0050819|GO:0045184|GO:0009890|GO:0048306|GO:0060548|GO:0006139|GO:0008104|GO:0007154|GO:0044092|GO:0007165|GO:0070062|GO:0008134|GO:0008219|GO:0031965|GO:0050790|GO:0051048|GO:1903531|GO:0043086|GO:0048869|GO:0044249|GO:0051224|GO:0031324|GO:0031323|GO:0051090|GO:0010468|GO:0034645|GO:0046872|GO:0007166|GO:0010629|GO:0043069|GO:0051252|GO:0050709|GO:0050710|GO:0051223|GO:0015031|GO:0070201|GO:0032717|GO:0051046|GO:0009306|GO:0048471|GO:0043433|GO:0055102|GO:0051059|GO:0050663|GO:0005544|GO:0012501|GO:0060429|GO:0010467|GO:0046903|GO:0009059|GO:0030154|GO:0050707|GO:0016070|GO:0005634|GO:0043067|GO:0032637|GO:0072606|GO:0030855|GO:0045892|GO:0032774|GO:2001141|GO:0050708|GO:1902679|GO:0005509|GO:0004859|GO:0042981|GO:0032088|GO:0043066|GO:0007219|GO:2000482|GO:2000483|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cell surface|negative regulation of transport|cellular metabolic process|cellular localization|membrane-bounded organelle|lipid binding|cell periphery|biosynthetic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|regulation of cellular localization|negative regulation of cytokine production|coagulation|enzyme inhibitor activity|cellular aromatic compound metabolic process|tissue development|transport|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|secretion by cell|phospholipid binding|vesicle|heterocycle metabolic process|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|cytoplasm|cytokine production|regulation of protein localization|vesicle membrane|nuclear envelope|negative regulation of coagulation|establishment of protein localization|negative regulation of biosynthetic process|calcium-dependent protein binding|negative regulation of cell death|nucleobase-containing compound metabolic process|protein localization|cell communication|negative regulation of molecular function|signal transduction|extracellular exosome|transcription factor binding|cell death|nuclear membrane|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|cell surface receptor signaling pathway|negative regulation of gene expression|negative regulation of programmed cell death|regulation of RNA metabolic process|negative regulation of protein secretion|negative regulation of cytokine secretion|regulation of protein transport|protein transport|regulation of establishment of protein localization|negative regulation of interleukin-8 production|regulation of secretion|protein secretion|perinuclear region of cytoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|lipase inhibitor activity|NF-kappaB binding|cytokine secretion|calcium-dependent phospholipid binding|programmed cell death|epithelium development|gene expression|secretion|macromolecule biosynthetic process|cell differentiation|regulation of cytokine secretion|RNA metabolic process|nucleus|regulation of programmed cell death|interleukin-8 production|interleukin-8 secretion|epithelial cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of protein secretion|negative regulation of RNA biosynthetic process|calcium ion binding|phospholipase inhibitor activity|regulation of apoptotic process|negative regulation of NF-kappaB transcription factor activity|negative regulation of apoptotic process|Notch signaling pathway|regulation of interleukin-8 secretion|negative regulation of interleukin-8 secretion|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 2:69644425-69827100 386 389 705 1194 1290 1331 1.94906233535733 1.78512320175715 3.20953376839836 5.40182548961945 5.34436777170446 6.29862218770475 2.31457310183761 5.68160514967622 -1.29555244468993 3.80441575645356e-08 6.33093801522656e-07 DOWN ENSG00000278341 RP5-1142A6.10 - - - - - - - 16:88708956-88710437 68 66 58 23 16 8 3.2456687336855 2.86299725858204 2.4959920833034 0.983621829184329 0.626588928412352 0.357865370966361 2.86821935852365 0.656025376187681 2.12833183716478 3.82736373991454e-08 6.36557755383893e-07 UP ENSG00000123975 CKS2 CDC28 protein kinase regulatory subunit 2 [Source:HGNC Symbol;Acc:HGNC:2000] GO:0000003|GO:0009987|GO:0022414|GO:0008152|GO:0008283|GO:0050794|GO:0044702|GO:0051321|GO:0071704|GO:0044237|GO:0016043|GO:0030234|GO:0019222|GO:0051726|GO:0007049|GO:0022402|GO:0007126|GO:0050790|GO:0051301|GO:0019207|GO:0019538|GO:0031323|GO:0006996|GO:0032268|GO:0043412|GO:0019887|GO:0036211|GO:0007127|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0016310|GO:0016538|GO:0006464|GO:0000079|GO:0043549|GO:0045859|GO:0006468|GO:0042325|GO:0001932|GO:0071900 reproduction|cellular process|reproductive process|metabolic process|cell proliferation|regulation of cellular process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|cellular metabolic process|cellular component organization|enzyme regulator activity|regulation of metabolic process|regulation of cell cycle|cell cycle|cell cycle process|meiotic nuclear division|regulation of catalytic activity|cell division|kinase regulator activity|protein metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|macromolecule modification|protein kinase regulator activity|protein modification process|meiosis I|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|phosphorylation|cyclin-dependent protein serine/threonine kinase regulator activity|cellular protein modification process|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|regulation of protein serine/threonine kinase activity K02219 cyclin-dependent kinase regulatory subunit CKS1[-] hsa05200|hsa05222 Pathways in cancer - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human) 9:89311198-89316703 2531 2503 2284 1315 1329 1035 292.06356210586 262.498091478819 237.62686150788 135.959269226368 125.82826415443 111.932054664743 264.062838364186 124.57319601518 1.08388760288205 3.85181375949811e-08 6.40267527706328e-07 UP ENSG00000147255 IGSF1 immunoglobulin superfamily member 1 [Source:HGNC Symbol;Acc:HGNC:5948] GO:0004871|GO:0023052|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0038023|GO:0009058|GO:0031224|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0034711|GO:0046483|GO:0006139|GO:0007154|GO:0007165|GO:0015026|GO:0016021|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 signal transducer activity|signaling|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|signaling receptor activity|biosynthetic process|intrinsic component of membrane|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|inhibin binding|heterocycle metabolic process|nucleobase-containing compound metabolic process|cell communication|signal transduction|coreceptor activity|integral component of membrane|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:131273506-131578899 7 8 14 40 49 72 0.0543662792173479 0.0564666684928146 0.0980338963498012 0.278345409097644 0.312239526054641 0.524059925471994 0.0696222813533212 0.37154828687476 -2.41592872381312 3.85552546693357e-08 6.40527864718057e-07 DOWN ENSG00000198826 ARHGAP11A Rho GTPase activating protein 11A [Source:HGNC Symbol;Acc:HGNC:15783] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0023051|GO:0009893|GO:0030234|GO:0005622|GO:0019222|GO:0008047|GO:0005737|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005829|GO:0005096|GO:0051345|GO:0030695|GO:0035556|GO:1902531|GO:0043087|GO:0043547|GO:0051056|GO:0007264 signaling|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of metabolic process|enzyme activator activity|cytoplasm|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cytosol|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 15:32615144-32639949 435 589 516 1235 1464 1098 2.34889499945444 2.89047720223128 2.51210741234394 5.97501466134664 6.48609852002405 5.55655844292265 2.58382653800989 6.00589054143111 -1.21686896198552 3.88225410840851e-08 6.44609644896705e-07 DOWN ENSG00000164674 SYTL3 synaptotagmin like 3 [Source:HGNC Symbol;Acc:HGNC:15587] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0019898|GO:0043229|GO:0043167|GO:0051641|GO:0043227|GO:0008289|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0006810|GO:0005102|GO:0043168|GO:0032940|GO:0005543|GO:0031982|GO:0030276|GO:0043231|GO:0043169|GO:0030133|GO:0019899|GO:0005737|GO:0045184|GO:0019897|GO:0000149|GO:0008104|GO:0051649|GO:0016192|GO:0046872|GO:0031410|GO:0015031|GO:0016023|GO:0006887|GO:0070382|GO:0046907|GO:0042043|GO:0031988|GO:0034613|GO:0005544|GO:0046903|GO:0051020|GO:0019905|GO:0005509|GO:0006886|GO:0031267|GO:0017016|GO:0017137 cell|membrane|cellular process|binding|extrinsic component of membrane|intracellular organelle|ion binding|cellular localization|membrane-bounded organelle|lipid binding|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|transport|receptor binding|anion binding|secretion by cell|phospholipid binding|vesicle|clathrin binding|intracellular membrane-bounded organelle|cation binding|transport vesicle|enzyme binding|cytoplasm|establishment of protein localization|extrinsic component of plasma membrane|SNARE binding|protein localization|establishment of localization in cell|vesicle-mediated transport|metal ion binding|cytoplasmic vesicle|protein transport|cytoplasmic, membrane-bounded vesicle|exocytosis|exocytic vesicle|intracellular transport|neurexin family protein binding|membrane-bounded vesicle|cellular protein localization|calcium-dependent phospholipid binding|secretion|GTPase binding|syntaxin binding|calcium ion binding|intracellular protein transport|small GTPase binding|Ras GTPase binding|Rab GTPase binding - - - - 6:158650014-158764876 4 10 16 50 49 58 0.0725472440494001 0.164839236100178 0.261653546653184 0.812542152286576 0.729199385462993 0.985914576707811 0.166346675600921 0.84255203815246 -2.34057275896513 3.89054570006461e-08 6.45627300332012e-07 DOWN ENSG00000155438 NIFK nucleolar protein interacting with the FHA domain of MKI67 [Source:HGNC Symbol;Acc:HGNC:17838] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0006139|GO:0044092|GO:0050790|GO:0000166|GO:0043086|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0005730|GO:0032268|GO:0034645|GO:0003723|GO:0043412|GO:0036211|GO:0032269|GO:0031981|GO:0051346|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0010923|GO:0016311|GO:0032774|GO:0000793|GO:0034660|GO:0000794|GO:0044822|GO:0006464|GO:0006351|GO:0010921|GO:0006470|GO:0035304|GO:0016072|GO:0035305|GO:0035303|GO:0035308|GO:0009303 cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|negative regulation of molecular function|regulation of catalytic activity|nucleotide binding|negative regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|nucleolus|regulation of cellular protein metabolic process|cellular macromolecule biosynthetic process|RNA binding|macromolecule modification|protein modification process|negative regulation of cellular protein metabolic process|nuclear lumen|negative regulation of hydrolase activity|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of phosphatase activity|dephosphorylation|RNA biosynthetic process|condensed chromosome|ncRNA metabolic process|condensed nuclear chromosome|poly(A) RNA binding|cellular protein modification process|transcription, DNA-templated|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|rRNA metabolic process|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation|rRNA transcription - - - - 2:121726945-121736923 2856 2595 1680 937 1175 644 44.0524345474712 36.3771831373289 23.3633501795948 12.9493761816234 14.8702191207381 9.30950268126494 34.5976559547983 12.3763659945421 1.48308653034822 3.91527141766786e-08 6.49369516128091e-07 UP ENSG00000132823 OSER1 oxidative stress responsive serine-rich 1 [Source:HGNC Symbol;Acc:HGNC:16105] GO:0009987|GO:0050896|GO:0051716|GO:0006950|GO:0033554|GO:0006979|GO:0010035|GO:0042542|GO:0034599|GO:0000302|GO:0034614|GO:0070301 cellular process|response to stimulus|cellular response to stimulus|response to stress|cellular response to stress|response to oxidative stress|response to inorganic substance|response to hydrogen peroxide|cellular response to oxidative stress|response to reactive oxygen species|cellular response to reactive oxygen species|cellular response to hydrogen peroxide - - - - 20:44196496-44210791 2111 2006 2115 1045 1125 1119 87.2228245635142 75.3274010038321 78.7891797222417 38.686202626067 38.1384008050023 43.3312250518222 80.4464684298627 40.0519428276305 1.00615686241173 3.91816644281906e-08 6.49488844996781e-07 UP ENSG00000117020 AKT3 v-akt murine thymoma viral oncogene homolog 3 [Source:HGNC Symbol;Acc:HGNC:393] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0000166|GO:0019538|GO:0005794|GO:0006996|GO:0035639|GO:0043412|GO:0007005|GO:0001883|GO:0036211|GO:0032549|GO:0031981|GO:0005654|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0016773|GO:0005634|GO:0000002|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0018193|GO:0004674|GO:0018105 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|nucleotide binding|protein metabolic process|Golgi apparatus|organelle organization|purine ribonucleoside triphosphate binding|macromolecule modification|mitochondrion organization|purine nucleoside binding|protein modification process|ribonucleoside binding|nuclear lumen|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|mitochondrial genome maintenance|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|peptidyl-serine phosphorylation K04456 RAC serine/threonine-protein kinase[2.7.11.1] hsa05200|hsa04151|hsa05166|hsa04010|hsa04014|hsa04015|hsa05205|hsa04510|hsa05169|hsa04024|hsa04062|hsa05152|hsa05164|hsa04022|hsa04630|hsa04932|hsa04261|hsa05161|hsa04072|hsa04550|hsa04210|hsa04910|hsa04530|hsa05162|hsa04068|hsa05160|hsa04380|hsa04728|hsa04152|hsa04611|hsa04722|hsa04071|hsa05145|hsa04919|hsa04725|hsa04668|hsa04931|hsa04620|hsa05142|hsa04660|hsa04066|hsa05231|hsa04933|hsa04922|hsa04915|hsa04914|hsa04211|hsa04666|hsa05215|hsa04012|hsa05222|hsa05220|hsa04662|hsa04917|hsa05218|hsa04920|hsa05230|hsa04664|hsa05211|hsa05212|hsa05214|hsa04213|hsa05210|hsa04370|hsa04150|hsa05221|hsa04923|hsa05223|hsa05213|hsa04973 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Measles - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Melanoma - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Glioma - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Regulation of lipolysis in adipocytes - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Carbohydrate digestion and absorption - Homo sapiens (human) 1:243488233-243851079 416 517 1255 2211 2490 2746 2.14354266217683 2.42107849646975 5.83037242735524 10.2076305670984 10.5270261040416 13.2607447723153 3.46499786200061 11.3318004811518 -1.70945073824871 3.93836158367401e-08 6.52474177130988e-07 DOWN ENSG00000132471 WBP2 WW domain binding protein 2 [Source:HGNC Symbol;Acc:HGNC:12738] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:0051130|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0001076|GO:0045184|GO:0003682|GO:0006139|GO:0000790|GO:0008104|GO:0009725|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0003713|GO:0051276|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0033993|GO:0043412|GO:0001104|GO:0031056|GO:0051252|GO:0006325|GO:0031058|GO:0016573|GO:0010628|GO:0036211|GO:0031981|GO:0051247|GO:0005694|GO:0000228|GO:0032270|GO:0014070|GO:0033043|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0001191|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0031490|GO:0010638|GO:2001252|GO:0000975|GO:0045893|GO:0031401|GO:0043566|GO:0032774|GO:0043565|GO:2001141|GO:0043966|GO:0043627|GO:0033044|GO:0071383|GO:0071407|GO:0035066|GO:0003690|GO:0040029|GO:0001105|GO:0045815|GO:0035065|GO:0016568|GO:0006464|GO:0071396|GO:0006351|GO:0006355|GO:0044154|GO:0045944|GO:0006366|GO:0071442|GO:0006357|GO:1903506|GO:0044212|GO:0001190|GO:0018193|GO:0071440|GO:1901985|GO:0071391|GO:0001047|GO:0000976|GO:0001012|GO:0006473|GO:0018205|GO:0018394|GO:0001046|GO:0000977|GO:0006475|GO:0018393|GO:0000979 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|transcription factor activity, RNA polymerase II transcription factor binding|establishment of protein localization|chromatin binding|nucleobase-containing compound metabolic process|nuclear chromatin|protein localization|response to hormone|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|chromosome organization|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|macromolecule modification|RNA polymerase II transcription cofactor activity|regulation of histone modification|regulation of RNA metabolic process|chromatin organization|positive regulation of histone modification|histone acetylation|positive regulation of gene expression|protein modification process|nuclear lumen|positive regulation of protein metabolic process|chromosome|nuclear chromosome|positive regulation of cellular protein metabolic process|response to organic cyclic compound|regulation of organelle organization|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|chromatin DNA binding|positive regulation of organelle organization|positive regulation of chromosome organization|regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|structure-specific DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|histone H3 acetylation|response to estrogen|regulation of chromosome organization|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|positive regulation of histone acetylation|double-stranded DNA binding|regulation of gene expression, epigenetic|RNA polymerase II transcription coactivator activity|positive regulation of gene expression, epigenetic|regulation of histone acetylation|chromatin modification|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|histone H3-K14 acetylation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|positive regulation of histone H3-K14 acetylation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcriptional activator activity, RNA polymerase II transcription factor binding|peptidyl-amino acid modification|regulation of histone H3-K14 acetylation|positive regulation of protein acetylation|cellular response to estrogen stimulus|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|core promoter sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|RNA polymerase II core promoter sequence-specific DNA binding - - - - 17:75845699-75856507 1957 2311 2642 859 1353 1219 9.50573667047151 10.2017556875187 11.5702264632267 3.73840039965857 5.39213501168721 5.5491641850921 10.425906273739 4.89323319881263 1.0913128510126 4.01207621074519e-08 6.64317932310521e-07 UP ENSG00000121310 ECHDC2 enoyl-CoA hydratase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:23408] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0016829|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0044255|GO:0006082|GO:0044281|GO:0043231|GO:0005737|GO:0006629|GO:0006631|GO:0005739|GO:0019752|GO:0032787 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|lyase activity|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|fatty acid metabolic process|mitochondrion|carboxylic acid metabolic process|monocarboxylic acid metabolic process - - - - 1:52895910-52927212 110 158 226 479 426 575 0.365203380692887 0.476738652421523 0.676496726796903 1.42487724426862 1.1604355872867 1.78912506952104 0.506146253303771 1.45814596702545 -1.52650892352603 4.03934082383527e-08 6.68429446110765e-07 DOWN ENSG00000151320 AKAP6 A-kinase anchoring protein 6 [Source:HGNC Symbol;Acc:HGNC:376] GO:0032502|GO:0040007|GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0016049|GO:0042175|GO:0071704|GO:0032947|GO:0044237|GO:0051641|GO:0023051|GO:0005911|GO:0016043|GO:0045927|GO:0043227|GO:0071944|GO:0040008|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0005789|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0007507|GO:0060341|GO:0051282|GO:0042391|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0044325|GO:0006810|GO:1901360|GO:0033017|GO:0044853|GO:0007275|GO:0010524|GO:0048513|GO:0044291|GO:0034641|GO:0030307|GO:0046620|GO:0044281|GO:0043270|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0043495|GO:0035265|GO:0061061|GO:0030315|GO:0055017|GO:0045597|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0003012|GO:0051018|GO:0032880|GO:0051222|GO:0005635|GO:0042592|GO:0009966|GO:0045184|GO:0009890|GO:0042383|GO:0019725|GO:0048639|GO:0032388|GO:0010646|GO:0006139|GO:0043085|GO:0055086|GO:1900182|GO:0008104|GO:1902495|GO:0007154|GO:0055085|GO:0046622|GO:0007165|GO:0048588|GO:0005783|GO:0048638|GO:1901863|GO:0051649|GO:2000021|GO:0090316|GO:0031965|GO:0050790|GO:0071804|GO:0051238|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0010469|GO:0019538|GO:0010033|GO:0098857|GO:0001558|GO:0031324|GO:0031323|GO:0032411|GO:0014701|GO:1902533|GO:0005901|GO:0032268|GO:0042307|GO:0051149|GO:0086009|GO:0016528|GO:0010613|GO:0014074|GO:0043412|GO:0072594|GO:0072358|GO:0034097|GO:0051345|GO:0019693|GO:0010720|GO:0042692|GO:0048878|GO:0046683|GO:0060421|GO:0035051|GO:0032386|GO:0048738|GO:0061051|GO:0061049|GO:0051223|GO:0060420|GO:0015031|GO:0014704|GO:0055006|GO:0034237|GO:0090257|GO:0001508|GO:0071417|GO:0051208|GO:0045844|GO:0034767|GO:0051147|GO:0036211|GO:0070201|GO:0060537|GO:0046907|GO:0006811|GO:0008179|GO:0051209|GO:0055082|GO:0051279|GO:0051247|GO:0048471|GO:0034765|GO:0034702|GO:0051591|GO:0055001|GO:1904591|GO:0043269|GO:0034613|GO:0043268|GO:0032270|GO:0014070|GO:0006796|GO:0035556|GO:1901137|GO:0044267|GO:0051174|GO:0010611|GO:0051281|GO:0014896|GO:0017038|GO:0071310|GO:0032414|GO:0060306|GO:0051246|GO:0071805|GO:0010522|GO:0030154|GO:0045121|GO:0007517|GO:1903827|GO:1902531|GO:0051928|GO:0072359|GO:0005634|GO:0060314|GO:0016529|GO:0022898|GO:0006606|GO:2000273|GO:0034220|GO:0016202|GO:0055002|GO:0050850|GO:1904589|GO:0055024|GO:0051153|GO:0010737|GO:0016311|GO:0098655|GO:0033365|GO:0033157|GO:0031401|GO:1901379|GO:0051169|GO:0009259|GO:0009117|GO:0010922|GO:0055013|GO:0046390|GO:0090280|GO:0034703|GO:0006812|GO:0045980|GO:1901021|GO:0010880|GO:0006605|GO:0014808|GO:0060402|GO:0071407|GO:0016482|GO:0006886|GO:0032412|GO:2001259|GO:0006163|GO:0042993|GO:0051146|GO:0071345|GO:0050801|GO:0042306|GO:0071320|GO:1900180|GO:1904427|GO:0014706|GO:0055007|GO:0006464|GO:0019932|GO:0009165|GO:1901381|GO:0050848|GO:0051155|GO:0042991|GO:0060316|GO:0010738|GO:0006873|GO:0090279|GO:0010921|GO:1901018|GO:0046824|GO:0070296|GO:0006470|GO:0003300|GO:0035304|GO:1903533|GO:1903169|GO:1901016|GO:0006913|GO:0006164|GO:0019935|GO:0043266|GO:0035307|GO:0043666|GO:0032516|GO:0051533|GO:0051531|GO:0034704|GO:2000727|GO:1901019|GO:0070886|GO:0009187|GO:0030001|GO:0070884|GO:0019722|GO:0048016|GO:0042990|GO:0035306|GO:0051924|GO:2001257|GO:0030003|GO:0015672|GO:0035303|GO:0034504|GO:0046822|GO:0030802|GO:0009190|GO:1902259|GO:0030818|GO:0006813|GO:1902261|GO:0051170|GO:0070588|GO:0046058|GO:0055065|GO:0009152|GO:0030817|GO:0097553|GO:0033173|GO:0052652|GO:0006875|GO:0030814|GO:0032514|GO:0030815|GO:0019933|GO:0006171|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|growth|macromolecular complex|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|cell growth|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|protein complex scaffold|cellular metabolic process|cellular localization|regulation of signaling|cell-cell junction|cellular component organization|positive regulation of growth|membrane-bounded organelle|cell periphery|regulation of growth|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|endoplasmic reticulum membrane|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|heart development|regulation of cellular localization|regulation of sequestering of calcium ion|regulation of membrane potential|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|ion channel binding|transport|organic cyclic compound metabolic process|sarcoplasmic reticulum membrane|plasma membrane raft|multicellular organism development|positive regulation of calcium ion transport into cytosol|animal organ development|cell-cell contact zone|cellular nitrogen compound metabolic process|positive regulation of cell growth|regulation of organ growth|small molecule metabolic process|positive regulation of ion transport|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|protein anchor|organ growth|muscle structure development|T-tubule|cardiac muscle tissue growth|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|muscle system process|protein kinase A binding|regulation of protein localization|positive regulation of protein transport|nuclear envelope|homeostatic process|regulation of signal transduction|establishment of protein localization|negative regulation of biosynthetic process|sarcolemma|cellular homeostasis|positive regulation of developmental growth|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|positive regulation of protein localization to nucleus|protein localization|transmembrane transporter complex|cell communication|transmembrane transport|positive regulation of organ growth|signal transduction|developmental cell growth|endoplasmic reticulum|regulation of developmental growth|positive regulation of muscle tissue development|establishment of localization in cell|regulation of ion homeostasis|positive regulation of intracellular protein transport|nuclear membrane|regulation of catalytic activity|cellular potassium ion transport|sequestering of metal ion|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|regulation of receptor activity|protein metabolic process|response to organic substance|membrane microdomain|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of transporter activity|junctional sarcoplasmic reticulum membrane|positive regulation of intracellular signal transduction|caveola|regulation of cellular protein metabolic process|positive regulation of protein import into nucleus|positive regulation of muscle cell differentiation|membrane repolarization|sarcoplasm|positive regulation of cardiac muscle hypertrophy|response to purine-containing compound|macromolecule modification|establishment of protein localization to organelle|cardiovascular system development|response to cytokine|positive regulation of hydrolase activity|ribose phosphate metabolic process|positive regulation of cell development|muscle cell differentiation|chemical homeostasis|response to organophosphorus|positive regulation of heart growth|cardiocyte differentiation|regulation of intracellular transport|cardiac muscle tissue development|positive regulation of cell growth involved in cardiac muscle cell development|cell growth involved in cardiac muscle cell development|regulation of protein transport|regulation of heart growth|protein transport|intercalated disc|cardiac cell development|protein kinase A regulatory subunit binding|regulation of muscle system process|action potential|cellular response to organonitrogen compound|sequestering of calcium ion|positive regulation of striated muscle tissue development|positive regulation of ion transmembrane transport|regulation of muscle cell differentiation|protein modification process|regulation of establishment of protein localization|muscle tissue development|intracellular transport|ion transport|adenylate cyclase binding|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|regulation of release of sequestered calcium ion into cytosol|positive regulation of protein metabolic process|perinuclear region of cytoplasm|regulation of ion transmembrane transport|ion channel complex|response to cAMP|muscle cell development|positive regulation of protein import|regulation of ion transport|cellular protein localization|positive regulation of potassium ion transport|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of cardiac muscle hypertrophy|positive regulation of release of sequestered calcium ion into cytosol|muscle hypertrophy|protein import|cellular response to organic substance|positive regulation of ion transmembrane transporter activity|regulation of membrane repolarization|regulation of protein metabolic process|potassium ion transmembrane transport|regulation of calcium ion transport into cytosol|cell differentiation|membrane raft|muscle organ development|regulation of cellular protein localization|regulation of intracellular signal transduction|positive regulation of calcium ion transport|circulatory system development|nucleus|regulation of ryanodine-sensitive calcium-release channel activity|sarcoplasmic reticulum|regulation of transmembrane transporter activity|protein import into nucleus|positive regulation of receptor activity|ion transmembrane transport|regulation of striated muscle tissue development|striated muscle cell development|positive regulation of calcium-mediated signaling|regulation of protein import|regulation of cardiac muscle tissue development|regulation of striated muscle cell differentiation|protein kinase A signaling|dephosphorylation|cation transmembrane transport|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|regulation of potassium ion transmembrane transport|nuclear transport|ribonucleotide metabolic process|nucleotide metabolic process|positive regulation of phosphatase activity|cardiac muscle cell development|ribose phosphate biosynthetic process|positive regulation of calcium ion import|cation channel complex|cation transport|negative regulation of nucleotide metabolic process|positive regulation of calcium ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|protein targeting|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|calcium ion transport into cytosol|cellular response to organic cyclic compound|cytosolic transport|intracellular protein transport|regulation of ion transmembrane transporter activity|positive regulation of cation channel activity|purine nucleotide metabolic process|positive regulation of transcription factor import into nucleus|striated muscle cell differentiation|cellular response to cytokine stimulus|ion homeostasis|regulation of protein import into nucleus|cellular response to cAMP|regulation of protein localization to nucleus|positive regulation of calcium ion transmembrane transport|striated muscle tissue development|cardiac muscle cell differentiation|cellular protein modification process|second-messenger-mediated signaling|nucleotide biosynthetic process|positive regulation of potassium ion transmembrane transport|regulation of calcium-mediated signaling|positive regulation of striated muscle cell differentiation|transcription factor import into nucleus|positive regulation of ryanodine-sensitive calcium-release channel activity|regulation of protein kinase A signaling|cellular ion homeostasis|regulation of calcium ion import|regulation of phosphatase activity|positive regulation of potassium ion transmembrane transporter activity|positive regulation of nucleocytoplasmic transport|sarcoplasmic reticulum calcium ion transport|protein dephosphorylation|cardiac muscle hypertrophy|regulation of protein dephosphorylation|regulation of protein targeting|regulation of calcium ion transmembrane transport|regulation of potassium ion transmembrane transporter activity|nucleocytoplasmic transport|purine nucleotide biosynthetic process|cyclic-nucleotide-mediated signaling|regulation of potassium ion transport|positive regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of NFAT protein import into nucleus|NFAT protein import into nucleus|calcium channel complex|positive regulation of cardiac muscle cell differentiation|regulation of calcium ion transmembrane transporter activity|positive regulation of calcineurin-NFAT signaling cascade|cyclic nucleotide metabolic process|metal ion transport|regulation of calcineurin-NFAT signaling cascade|calcium-mediated signaling|inositol phosphate-mediated signaling|regulation of transcription factor import into nucleus|positive regulation of dephosphorylation|regulation of calcium ion transport|regulation of cation channel activity|cellular cation homeostasis|monovalent inorganic cation transport|regulation of dephosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|regulation of delayed rectifier potassium channel activity|negative regulation of cAMP biosynthetic process|potassium ion transport|positive regulation of delayed rectifier potassium channel activity|nuclear import|calcium ion transmembrane transport|cAMP metabolic process|metal ion homeostasis|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|calcium ion transmembrane import into cytosol|calcineurin-NFAT signaling cascade|cyclic purine nucleotide metabolic process|cellular metal ion homeostasis|regulation of cAMP metabolic process|positive regulation of protein phosphatase type 2B activity|negative regulation of cAMP metabolic process|cAMP-mediated signaling|cAMP biosynthetic process|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration - - - - 14:32329273-32837681 12 20 54 128 141 204 0.0341927421383581 0.0517903021663333 0.138723437503778 0.326774053847847 0.329629005361668 0.544750844238465 0.0749021606028231 0.40038463448266 -2.41830736918802 4.04138524227886e-08 6.68429446110765e-07 DOWN ENSG00000179094 PER1 period circadian clock 1 [Source:HGNC Symbol;Acc:HGNC:8845] GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0042752|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0071704|GO:0009628|GO:0044237|GO:0023051|GO:0000989|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0002532|GO:0006725|GO:0009314|GO:0006810|GO:1901360|GO:0016570|GO:0003676|GO:0097167|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0032922|GO:0001817|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0001816|GO:0009611|GO:0009966|GO:0009890|GO:0003682|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0008134|GO:0009725|GO:0042634|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0009649|GO:0006996|GO:0000165|GO:0051276|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0006518|GO:0014074|GO:0033993|GO:0043412|GO:0010629|GO:0050727|GO:0051252|GO:0046683|GO:0006325|GO:0016573|GO:0010628|GO:0036211|GO:0032269|GO:0006811|GO:0006954|GO:0031098|GO:0033143|GO:0051591|GO:0033144|GO:0043269|GO:0019900|GO:0014070|GO:0006796|GO:0043603|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:1902532|GO:1900015|GO:0031328|GO:0051246|GO:0009059|GO:0009755|GO:1902531|GO:0016070|GO:0032870|GO:0010557|GO:0016575|GO:0005634|GO:0009416|GO:0048545|GO:0030522|GO:0043153|GO:0002534|GO:0044389|GO:0042633|GO:0031490|GO:0043401|GO:0031625|GO:0000975|GO:0045893|GO:0043043|GO:0043124|GO:0043122|GO:0043566|GO:0043408|GO:2000323|GO:0045892|GO:0032774|GO:0043565|GO:0006812|GO:2001141|GO:0043966|GO:0043967|GO:0016310|GO:0010608|GO:1902679|GO:0009648|GO:0071383|GO:0071407|GO:0003690|GO:0030518|GO:0006412|GO:0007249|GO:0006417|GO:0032872|GO:0043409|GO:0016568|GO:0070932|GO:0006464|GO:0071396|GO:0051403|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:1900744|GO:0046328|GO:0006357|GO:0038066|GO:0006468|GO:1903506|GO:0044212|GO:0042325|GO:0007254|GO:0001932|GO:0018193|GO:0042326|GO:0002028|GO:0030001|GO:0001933|GO:0000122|GO:0015672|GO:0032873|GO:0006814|GO:0000976|GO:0042921|GO:0001012|GO:0006476|GO:0070888|GO:0001159|GO:0006473|GO:0018205|GO:0046329|GO:0018394|GO:0000977|GO:0000987|GO:0006475|GO:0018393|GO:0000978 signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|regulation of circadian rhythm|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|production of molecular mediator involved in inflammatory response|cellular aromatic compound metabolic process|response to radiation|transport|organic cyclic compound metabolic process|histone modification|nucleic acid binding|circadian regulation of translation|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|circadian regulation of gene expression|regulation of cytokine production|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|cytokine production|response to wounding|regulation of signal transduction|negative regulation of biosynthetic process|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|transcription factor binding|response to hormone|regulation of hair cycle|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|entrainment of circadian clock|organelle organization|MAPK cascade|chromosome organization|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|response to purine-containing compound|response to lipid|macromolecule modification|negative regulation of gene expression|regulation of inflammatory response|regulation of RNA metabolic process|response to organophosphorus|chromatin organization|histone acetylation|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|ion transport|inflammatory response|stress-activated protein kinase signaling cascade|regulation of intracellular steroid hormone receptor signaling pathway|response to cAMP|negative regulation of intracellular steroid hormone receptor signaling pathway|regulation of ion transport|kinase binding|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of cytokine production involved in inflammatory response|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|regulation of intracellular signal transduction|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|response to light stimulus|response to steroid hormone|intracellular receptor signaling pathway|entrainment of circadian clock by photoperiod|cytokine production involved in inflammatory response|ubiquitin-like protein ligase binding|hair cycle|chromatin DNA binding|steroid hormone mediated signaling pathway|ubiquitin protein ligase binding|regulatory region DNA binding|positive regulation of transcription, DNA-templated|peptide biosynthetic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of I-kappaB kinase/NF-kappaB signaling|structure-specific DNA binding|regulation of MAPK cascade|negative regulation of glucocorticoid receptor signaling pathway|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|cation transport|regulation of RNA biosynthetic process|histone H3 acetylation|histone H4 acetylation|phosphorylation|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|photoperiodism|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|translation|I-kappaB kinase/NF-kappaB signaling|regulation of translation|regulation of stress-activated MAPK cascade|negative regulation of MAPK cascade|chromatin modification|histone H3 deacetylation|cellular protein modification process|cellular response to lipid|stress-activated MAPK cascade|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of p38MAPK cascade|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|p38MAPK cascade|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|regulation of sodium ion transport|metal ion transport|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|monovalent inorganic cation transport|negative regulation of stress-activated MAPK cascade|sodium ion transport|transcription regulatory region sequence-specific DNA binding|glucocorticoid receptor signaling pathway|RNA polymerase II regulatory region DNA binding|protein deacetylation|E-box binding|core promoter proximal region DNA binding|protein acetylation|peptidyl-lysine modification|negative regulation of JNK cascade|peptidyl-lysine acetylation|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|RNA polymerase II core promoter proximal region sequence-specific DNA binding K02633 period circadian protein[-] hsa05168|hsa04713|hsa04710 Herpes simplex infection - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Circadian rhythm - Homo sapiens (human) 17:8140472-8156506 1184 1237 1586 439 478 790 5.59281789159348 5.31041629020251 6.75455006884754 1.85798094025548 1.85257093739167 3.49731531927777 5.88592808354784 2.40262239897497 1.29265998560802 4.04437731389767e-08 6.68553933162243e-07 UP ENSG00000117616 RSRP1 arginine/serine-rich protein 1 [Source:HGNC Symbol;Acc:HGNC:25234] GO:0005488|GO:0005515 binding|protein binding - - - - 1:25242237-25338213 1110 1032 1330 372 731 341 4.25041407592987 3.59143380040683 4.59170716504929 1.27629013972814 2.29664435333988 1.22374599923228 4.14451834712866 1.59889349743343 1.37413060561124 4.05574487350435e-08 6.70062022432755e-07 UP ENSG00000054793 ATP9A ATPase, class II, type 9A [Source:HGNC Symbol;Acc:HGNC:13540] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0097035|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0005319|GO:0061024|GO:0051649|GO:0010008|GO:0000166|GO:0016021|GO:0010876|GO:0005794|GO:0005768|GO:0016192|GO:0005802|GO:0046872|GO:0035639|GO:0005548|GO:0005769|GO:0001883|GO:0016818|GO:0046907|GO:0006811|GO:0032549|GO:0055037|GO:0006869|GO:0048471|GO:0031901|GO:0017076|GO:0015914|GO:0045332|GO:0006820|GO:0015711|GO:0000287|GO:0005524|GO:0030554|GO:0048193|GO:0004012|GO:0006897|GO:0016462|GO:0017111|GO:0006890|GO:0016887|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|organelle membrane|regulation of membrane lipid distribution|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|lipid transporter activity|membrane organization|establishment of localization in cell|endosome membrane|nucleotide binding|integral component of membrane|lipid localization|Golgi apparatus|endosome|vesicle-mediated transport|trans-Golgi network|metal ion binding|purine ribonucleoside triphosphate binding|phospholipid transporter activity|early endosome|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ion transport|ribonucleoside binding|recycling endosome|lipid transport|perinuclear region of cytoplasm|early endosome membrane|purine nucleotide binding|phospholipid transport|phospholipid translocation|anion transport|organic anion transport|magnesium ion binding|ATP binding|adenyl nucleotide binding|Golgi vesicle transport|phospholipid-translocating ATPase activity|endocytosis|pyrophosphatase activity|nucleoside-triphosphatase activity|retrograde vesicle-mediated transport, Golgi to ER|ATPase activity|ATPase activity, coupled|ATPase activity, coupled to movement of substances - - - - 20:51596514-51768634 480 538 708 1233 1362 1732 4.06923543598907 4.14508980918686 5.41151238534347 9.36552377258237 9.47363359756282 13.7609415641527 4.5419458768398 10.866699644766 -1.2585314223291 4.06856759275287e-08 6.71808721869714e-07 DOWN ENSG00000142856 ITGB3BP integrin subunit beta 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6157] GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0007155|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0007049|GO:0006725|GO:0008022|GO:0022402|GO:1901360|GO:0010941|GO:0034641|GO:0000776|GO:0046483|GO:0022607|GO:0010942|GO:0043231|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0008219|GO:0051301|GO:0044249|GO:0010033|GO:0031323|GO:0006996|GO:0051276|GO:0005829|GO:0010468|GO:0034645|GO:0007166|GO:1903047|GO:0051252|GO:0006325|GO:0000278|GO:0031981|GO:0070848|GO:0005654|GO:0005694|GO:0006461|GO:0012501|GO:0035556|GO:0007067|GO:0010467|GO:0071310|GO:0009059|GO:0043068|GO:0016070|GO:0005634|GO:0000777|GO:0043067|GO:0097190|GO:0006334|GO:0034622|GO:0043065|GO:0032774|GO:0000793|GO:2001141|GO:0034728|GO:0071363|GO:0038179|GO:0034508|GO:0007167|GO:0006333|GO:0065004|GO:0031497|GO:0042981|GO:0016568|GO:0007264|GO:0071103|GO:0006351|GO:0006915|GO:0006355|GO:0000775|GO:0006336|GO:0048011|GO:0006323|GO:0043486|GO:0000779|GO:1903506|GO:0006338|GO:0034080|GO:0007169|GO:0043044 macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|cell adhesion|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|protein C-terminus binding|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|kinetochore|heterocycle metabolic process|cellular component assembly|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|cell death|cell division|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|organelle organization|chromosome organization|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|mitotic cell cycle process|regulation of RNA metabolic process|chromatin organization|mitotic cell cycle|nuclear lumen|response to growth factor|nucleoplasm|chromosome|protein complex assembly|programmed cell death|intracellular signal transduction|mitotic nuclear division|gene expression|cellular response to organic substance|macromolecule biosynthetic process|positive regulation of programmed cell death|RNA metabolic process|nucleus|condensed chromosome kinetochore|regulation of programmed cell death|apoptotic signaling pathway|nucleosome assembly|cellular macromolecular complex assembly|positive regulation of apoptotic process|RNA biosynthetic process|condensed chromosome|regulation of RNA biosynthetic process|nucleosome organization|cellular response to growth factor stimulus|neurotrophin signaling pathway|centromere complex assembly|enzyme linked receptor protein signaling pathway|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|regulation of apoptotic process|chromatin modification|small GTPase mediated signal transduction|DNA conformation change|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|chromosome, centromeric region|DNA replication-independent nucleosome assembly|neurotrophin TRK receptor signaling pathway|DNA packaging|histone exchange|condensed chromosome, centromeric region|regulation of nucleic acid-templated transcription|chromatin remodeling|CENP-A containing nucleosome assembly|transmembrane receptor protein tyrosine kinase signaling pathway|ATP-dependent chromatin remodeling - - - - 1:63440770-63593721 291 325 422 810 922 753 2.54883947519503 2.58709801886521 3.33254958631448 6.35670621840155 6.62594892717899 6.18120879893604 2.82282902679157 6.38795464817219 -1.17821232001981 4.11205908353375e-08 6.78614769927123e-07 DOWN ENSG00000173545 ZNF622 zinc finger protein 622 [Source:HGNC Symbol;Acc:HGNC:30958] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0010941|GO:0003676|GO:0031325|GO:0033554|GO:0010942|GO:0043231|GO:0043169|GO:0005737|GO:0030529|GO:0009966|GO:0006979|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0009967|GO:0022613|GO:0019538|GO:0023014|GO:0031323|GO:0005794|GO:0000165|GO:1902533|GO:0005730|GO:0032268|GO:0005829|GO:0046872|GO:0003723|GO:0030684|GO:0043412|GO:0005840|GO:0042254|GO:0051347|GO:0036211|GO:0031981|GO:0031098|GO:0034599|GO:0051247|GO:0015934|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0042273|GO:0051246|GO:0043068|GO:1902531|GO:0005634|GO:0043067|GO:0097190|GO:0070304|GO:0097193|GO:0030687|GO:0031401|GO:0008631|GO:0043065|GO:0043408|GO:0022626|GO:0016310|GO:0022625|GO:0043410|GO:0032872|GO:0042981|GO:0046914|GO:0044822|GO:0006464|GO:0051403|GO:0043549|GO:0006915|GO:0033674|GO:0046328|GO:0006468|GO:0042325|GO:0007254|GO:0001932|GO:0032874|GO:0001934|GO:0008270|GO:0042327|GO:0046330 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|endomembrane system|regulation of metabolic process|regulation of cell death|nucleic acid binding|positive regulation of cellular metabolic process|cellular response to stress|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|cytoplasm|intracellular ribonucleoprotein complex|regulation of signal transduction|response to oxidative stress|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|positive regulation of signal transduction|ribonucleoprotein complex biogenesis|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|Golgi apparatus|MAPK cascade|positive regulation of intracellular signal transduction|nucleolus|regulation of cellular protein metabolic process|cytosol|metal ion binding|RNA binding|preribosome|macromolecule modification|ribosome|ribosome biogenesis|positive regulation of transferase activity|protein modification process|nuclear lumen|stress-activated protein kinase signaling cascade|cellular response to oxidative stress|positive regulation of protein metabolic process|large ribosomal subunit|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|ribosomal large subunit biogenesis|regulation of protein metabolic process|positive regulation of programmed cell death|regulation of intracellular signal transduction|nucleus|regulation of programmed cell death|apoptotic signaling pathway|positive regulation of stress-activated protein kinase signaling cascade|intrinsic apoptotic signaling pathway|preribosome, large subunit precursor|positive regulation of protein modification process|intrinsic apoptotic signaling pathway in response to oxidative stress|positive regulation of apoptotic process|regulation of MAPK cascade|cytosolic ribosome|phosphorylation|cytosolic large ribosomal subunit|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|transition metal ion binding|poly(A) RNA binding|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of JNK cascade|protein phosphorylation|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|zinc ion binding|positive regulation of phosphorylation|positive regulation of JNK cascade - - - - 5:16451519-16465792 1404 1413 1336 711 803 560 58.4547149179791 53.4655968874036 50.1502500129111 26.522824853135 27.4306425918211 21.850895536815 54.0235206060979 25.2681209939237 1.09626927494435 4.12411815971985e-08 6.80228859338544e-07 UP ENSG00000074621 SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 [Source:HGNC Symbol;Acc:HGNC:10975] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0022857|GO:0051606|GO:0050794|GO:0043167|GO:0009628|GO:0019867|GO:0071944|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0009314|GO:0006810|GO:0050877|GO:0009582|GO:0005887|GO:0043169|GO:0042592|GO:0019725|GO:0022891|GO:0031226|GO:0007154|GO:0055085|GO:0007165|GO:0016021|GO:0007186|GO:0046872|GO:0009583|GO:0048878|GO:0015267|GO:0006811|GO:0055082|GO:0007602|GO:0015075|GO:0007600|GO:0071478|GO:0009416|GO:0034220|GO:0009642|GO:0050953|GO:0098655|GO:0005216|GO:0015293|GO:0015297|GO:0016056|GO:0006812|GO:0005509|GO:0009584|GO:0071482|GO:0050801|GO:0007603|GO:0006873|GO:0008324|GO:0022890|GO:0015491|GO:0030001|GO:0030955|GO:0005261|GO:0007601|GO:0030003|GO:0015672|GO:0031402|GO:0005262|GO:0035725|GO:0070588|GO:0006814|GO:0055065|GO:0006875|GO:0015077|GO:0008273|GO:0015368|GO:0046873|GO:0015079|GO:0006874|GO:0006816|GO:0055074|GO:0015085|GO:0015081 transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|transmembrane transporter activity|detection of stimulus|regulation of cellular process|ion binding|response to abiotic stimulus|outer membrane|cell periphery|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|response to radiation|transport|neurological system process|detection of abiotic stimulus|integral component of plasma membrane|cation binding|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|cell communication|transmembrane transport|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|metal ion binding|detection of light stimulus|chemical homeostasis|channel activity|ion transport|cellular chemical homeostasis|phototransduction|ion transmembrane transporter activity|sensory perception|cellular response to radiation|response to light stimulus|ion transmembrane transport|response to light intensity|sensory perception of light stimulus|cation transmembrane transport|ion channel activity|symporter activity|antiporter activity|rhodopsin mediated signaling pathway|cation transport|calcium ion binding|detection of visible light|cellular response to light stimulus|ion homeostasis|phototransduction, visible light|cellular ion homeostasis|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|cation:cation antiporter activity|metal ion transport|potassium ion binding|cation channel activity|visual perception|cellular cation homeostasis|monovalent inorganic cation transport|sodium ion binding|calcium channel activity|sodium ion transmembrane transport|calcium ion transmembrane transport|sodium ion transport|metal ion homeostasis|cellular metal ion homeostasis|monovalent inorganic cation transmembrane transporter activity|calcium, potassium:sodium antiporter activity|calcium:cation antiporter activity|metal ion transmembrane transporter activity|potassium ion transmembrane transporter activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|calcium ion transmembrane transporter activity|sodium ion transmembrane transporter activity K13749 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1[-] hsa04744 Phototransduction - Homo sapiens (human) 15:65611366-65660995 61 67 88 211 207 228 0.258119235099552 0.257658650712181 0.335726211581223 0.799956871056516 0.718664551648376 0.904172632552526 0.283834699130985 0.807598018419139 -1.50858639940085 4.21891095938271e-08 6.95095848683285e-07 DOWN ENSG00000103381 CPPED1 calcineurin-like phosphoesterase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25632] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005886|GO:0016788|GO:0031982|GO:0043169|GO:0005737|GO:0070062|GO:0019538|GO:0046872|GO:0043412|GO:0036211|GO:0006796|GO:0044267|GO:0042578|GO:0016311|GO:0016791|GO:0006464|GO:0006470|GO:0004721 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|plasma membrane|hydrolase activity, acting on ester bonds|vesicle|cation binding|cytoplasm|extracellular exosome|protein metabolic process|metal ion binding|macromolecule modification|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|phosphoric ester hydrolase activity|dephosphorylation|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity - - - - 16:12659799-12804017 310 358 440 862 971 790 2.16064621422452 2.26769673310739 2.7649629172 5.38303631086237 5.55276787261831 5.16034061544829 2.39776862151064 5.36538159964299 -1.16198833366968 4.21686002475648e-08 6.95095848683285e-07 DOWN ENSG00000120519 SLC10A7 solute carrier family 10 member 7 [Source:HGNC Symbol;Acc:HGNC:23088] GO:0005215|GO:0016020|GO:0009987|GO:0022857|GO:0031224|GO:0006810|GO:0055085|GO:0016021|GO:0006811|GO:0015293|GO:0006812|GO:0030001|GO:0015672|GO:0006814 transporter activity|membrane|cellular process|transmembrane transporter activity|intrinsic component of membrane|transport|transmembrane transport|integral component of membrane|ion transport|symporter activity|cation transport|metal ion transport|monovalent inorganic cation transport|sodium ion transport - - - - 4:146253975-146521964 32 11 48 167 141 150 0.208262630990807 0.0650649321490141 0.281652382692843 0.973801613320006 0.752909162490456 0.914907637148307 0.184993315277555 0.880539470986256 -2.25091453564529 4.31633372280676e-08 7.10754699176355e-07 DOWN ENSG00000067798 NAV3 neuron navigator 3 [Source:HGNC Symbol;Acc:HGNC:15998] GO:0005623|GO:0016020|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0042175|GO:0043167|GO:0043227|GO:0019867|GO:0005640|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0043168|GO:0001882|GO:0043231|GO:0005635|GO:0031965|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005634|GO:0005524|GO:0030554 cell|membrane|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|membrane-bounded organelle|outer membrane|nuclear outer membrane|intracellular|protein binding|endomembrane system|organelle membrane|anion binding|nucleoside binding|intracellular membrane-bounded organelle|nuclear envelope|nuclear membrane|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|nucleus|ATP binding|adenyl nucleotide binding - - - - 12:77830905-78213008 17 31 43 181 246 80 0.0694647161107536 0.115125457172262 0.158416966860844 0.662672147967118 0.824758426593714 0.306365564148291 0.114335713381287 0.597932046236374 -2.38670542679538 4.3259393931145e-08 7.11909444049426e-07 DOWN ENSG00000071909 MYO3B myosin IIIB [Source:HGNC Symbol;Acc:HGNC:15576] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0050877|GO:0043168|GO:0001882|GO:0016772|GO:0016817|GO:0005737|GO:0016459|GO:0008092|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0003779|GO:0016818|GO:0036211|GO:0032549|GO:0007600|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005856|GO:0015629|GO:0050953|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0016462|GO:0006468|GO:0017111|GO:0007601|GO:0003774 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|intracellular|protein binding|protein complex|transferase activity|neurological system process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|hydrolase activity, acting on acid anhydrides|cytoplasm|myosin complex|cytoskeletal protein binding|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|actin binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|ribonucleoside binding|sensory perception|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|actin cytoskeleton|sensory perception of light stimulus|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|pyrophosphatase activity|protein phosphorylation|nucleoside-triphosphatase activity|visual perception|motor activity - - - - 2:170178145-170655171 4 2 10 38 30 56 0.0273155292327341 0.0124130724230681 0.0615737130688487 0.232516729180119 0.168096278238506 0.358418165515063 0.0337674382415503 0.253010390977896 -2.90549199781298 4.32811563257757e-08 7.11909444049426e-07 DOWN ENSG00000156140 ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif 3 [Source:HGNC Symbol;Acc:HGNC:219] GO:0031012|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0050794|GO:0005578|GO:0071704|GO:0009056|GO:0043167|GO:0023051|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005615|GO:0005515|GO:0008201|GO:0043168|GO:0043062|GO:0031982|GO:0090287|GO:0043169|GO:0008233|GO:0001816|GO:0009966|GO:0044236|GO:0010646|GO:0007154|GO:0007165|GO:0070062|GO:0009967|GO:0019538|GO:0005539|GO:0010033|GO:0030574|GO:0044259|GO:0046872|GO:0007166|GO:0032964|GO:0051604|GO:0070848|GO:0006508|GO:0010467|GO:0071310|GO:0030198|GO:0009059|GO:1900746|GO:1900748|GO:0010573|GO:0008237|GO:0016485|GO:0071363|GO:0007167|GO:0004175|GO:0030199|GO:0097435|GO:0046914|GO:0032963|GO:0035924|GO:0043206|GO:0008270|GO:0004222|GO:0007169|GO:0038084 extracellular matrix|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|regulation of cellular process|proteinaceous extracellular matrix|organic substance metabolic process|catabolic process|ion binding|regulation of signaling|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|extracellular space|protein binding|heparin binding|anion binding|extracellular structure organization|vesicle|regulation of cellular response to growth factor stimulus|cation binding|peptidase activity|cytokine production|regulation of signal transduction|multicellular organism metabolic process|regulation of cell communication|cell communication|signal transduction|extracellular exosome|positive regulation of signal transduction|protein metabolic process|glycosaminoglycan binding|response to organic substance|collagen catabolic process|multicellular organismal macromolecule metabolic process|metal ion binding|cell surface receptor signaling pathway|collagen biosynthetic process|protein maturation|response to growth factor|proteolysis|gene expression|cellular response to organic substance|extracellular matrix organization|macromolecule biosynthetic process|regulation of vascular endothelial growth factor signaling pathway|positive regulation of vascular endothelial growth factor signaling pathway|vascular endothelial growth factor production|metallopeptidase activity|protein processing|cellular response to growth factor stimulus|enzyme linked receptor protein signaling pathway|endopeptidase activity|collagen fibril organization|fibril organization|transition metal ion binding|collagen metabolic process|cellular response to vascular endothelial growth factor stimulus|extracellular fibril organization|zinc ion binding|metalloendopeptidase activity|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor signaling pathway - - - - 4:72280969-72568799 2 7 8 32 34 46 0.0171475304116764 0.0545504896013765 0.0618453837543889 0.245833110934141 0.239185202137453 0.369635984379035 0.0445144679224806 0.284884765816876 -2.67803225911322 4.3524343066575e-08 7.15515274179257e-07 DOWN ENSG00000189108 IL1RAPL2 interleukin 1 receptor accessory protein-like 2 [Source:HGNC Symbol;Acc:HGNC:5997] GO:0032502|GO:0004871|GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0031224|GO:0005515|GO:0048856|GO:0007275|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0010033|GO:0007166|GO:0004896|GO:0034097|GO:0007417|GO:0007399|GO:0071310|GO:0019221|GO:0004908|GO:0071345|GO:0004910 developmental process|signal transducer activity|signaling|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|intrinsic component of membrane|protein binding|anatomical structure development|multicellular organism development|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|response to organic substance|cell surface receptor signaling pathway|cytokine receptor activity|response to cytokine|central nervous system development|nervous system development|cellular response to organic substance|cytokine-mediated signaling pathway|interleukin-1 receptor activity|cellular response to cytokine stimulus|interleukin-1, Type II, blocking receptor activity - - - - X:104566315-105767829 1 4 3 29 20 28 0.0176124174770069 0.0639993052056441 0.0476109461954384 0.457444665627721 0.288885380673631 0.461974221211377 0.0430742229593631 0.40276808917091 -3.22505270869393 4.39327545805322e-08 7.21831841082667e-07 DOWN ENSG00000004766 VPS50 VPS50 EARP/GARPII complex subunit [Source:HGNC Symbol;Acc:HGNC:25956] GO:0032991|GO:0005623|GO:0016020|GO:0005576|GO:1903561|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0043234|GO:0012505|GO:0006810|GO:0031982|GO:1990745|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0070062|GO:0051649|GO:0005768|GO:0016192|GO:0015031|GO:0046907|GO:0055037|GO:0032456|GO:0016197 macromolecular complex|cell|membrane|extracellular region|extracellular vesicle|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein complex|endomembrane system|transport|vesicle|EARP complex|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|extracellular exosome|establishment of localization in cell|endosome|vesicle-mediated transport|protein transport|intracellular transport|recycling endosome|endocytic recycling|endosomal transport - - - - 7:93232340-93361121 421 575 606 1294 1329 1167 2.00485985933956 2.48857069611706 2.6018916308538 5.52121086509534 5.19272424442343 5.20837459050441 2.36510739543681 5.30743656667439 -1.16610952811786 4.45088555750883e-08 7.30895145400818e-07 DOWN ENSG00000153815 CMIP c-Maf inducing protein [Source:HGNC Symbol;Acc:HGNC:24319] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nucleus - - - - 16:81445170-81711762 313 323 792 1318 1598 1642 1.23988532494168 1.16283972650486 2.82863203305832 4.67789340507802 5.19376110603014 6.09592172032206 1.74378569483495 5.32252541047674 -1.60988818348837 4.51453632627155e-08 7.40939898210614e-07 DOWN ENSG00000129055 ANAPC13 anaphase promoting complex subunit 13 [Source:HGNC Symbol;Acc:HGNC:24540] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0043229|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0043234|GO:0007049|GO:0022402|GO:0043231|GO:0051301|GO:0000151|GO:0019538|GO:0006996|GO:1903047|GO:0043412|GO:0031461|GO:0036211|GO:0000278|GO:1990234|GO:0044267|GO:0007067|GO:0005634|GO:0000152|GO:0005680|GO:0006464|GO:0032446|GO:0016567|GO:0000209|GO:0070979 macromolecular complex|cell|cellular process|metabolic process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein complex|cell cycle|cell cycle process|intracellular membrane-bounded organelle|cell division|ubiquitin ligase complex|protein metabolic process|organelle organization|mitotic cell cycle process|macromolecule modification|cullin-RING ubiquitin ligase complex|protein modification process|mitotic cell cycle|transferase complex|cellular protein metabolic process|mitotic nuclear division|nucleus|nuclear ubiquitin ligase complex|anaphase-promoting complex|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination|protein polyubiquitination|protein K11-linked ubiquitination K12456 anaphase-promoting complex subunit 13[-] hsa04120|hsa04110|hsa04114|hsa04914 Ubiquitin mediated proteolysis - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human) 3:134477706-134486716 2413 2592 2041 1217 1269 892 27.3231960264632 26.6740724165537 20.8368230083926 12.3470307083288 11.7897300186772 9.4660299560936 24.9446971504698 11.2009302276999 1.15511460207493 4.5386401332218e-08 7.44486607347273e-07 UP ENSG00000148572 NRBF2 nuclear receptor binding factor 2 [Source:HGNC Symbol;Acc:HGNC:19692] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0010506|GO:0006725|GO:1901360|GO:0034641|GO:0031982|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0005942|GO:0006139|GO:0006629|GO:0050790|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0035032|GO:0031410|GO:0051252|GO:0005773|GO:0016023|GO:0031981|GO:1990234|GO:0031988|GO:0005654|GO:0006796|GO:0051174|GO:0010467|GO:0019216|GO:0009059|GO:0016070|GO:0034976|GO:0005634|GO:0032774|GO:0043550|GO:2001141|GO:0016310|GO:0005776|GO:0043549|GO:0006351|GO:0006355|GO:0006366|GO:0006352|GO:1903506|GO:0042325|GO:0006367 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of autophagy|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|phosphatidylinositol 3-kinase complex|nucleobase-containing compound metabolic process|lipid metabolic process|regulation of catalytic activity|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|phosphatidylinositol 3-kinase complex, class III|cytoplasmic vesicle|regulation of RNA metabolic process|vacuole|cytoplasmic, membrane-bounded vesicle|nuclear lumen|transferase complex|membrane-bounded vesicle|nucleoplasm|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of lipid metabolic process|macromolecule biosynthetic process|RNA metabolic process|response to endoplasmic reticulum stress|nucleus|RNA biosynthetic process|regulation of lipid kinase activity|regulation of RNA biosynthetic process|phosphorylation|autophagosome|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|transcription initiation from RNA polymerase II promoter - - - - 10:63133247-63155031 1216 1326 1024 563 599 596 18.1851983513536 18.0222165444984 13.8069886967846 7.54381264920192 7.34986850211466 8.35332778385795 16.6714678642122 7.74900297839151 1.10529853034851 4.63002804343932e-08 7.59060171382963e-07 UP ENSG00000126012 KDM5C lysine (K)-specific demethylase 5C [Source:HGNC Symbol;Acc:HGNC:11114] GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0009892|GO:0048523|GO:0032451|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:0051213|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0032452|GO:0046483|GO:0006482|GO:0043231|GO:0043169|GO:0016705|GO:0070988|GO:0009890|GO:0006139|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0055114|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0032453|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0036211|GO:0031981|GO:0016706|GO:0005654|GO:0016577|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0070076|GO:0046914|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0034720|GO:1903507|GO:1903506|GO:0008270 cell|rhythmic process|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|demethylase activity|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|dioxygenase activity|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|histone demethylase activity|heterocycle metabolic process|protein demethylation|intracellular membrane-bounded organelle|cation binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|demethylation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|histone demethylase activity (H3-K4 specific)|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|protein modification process|nuclear lumen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|nucleoplasm|histone demethylation|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|histone lysine demethylation|transition metal ion binding|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|histone H3-K4 demethylation|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|zinc ion binding - - - - X:53191321-53225422 344 473 708 1215 1431 1277 1.55535136403324 1.94361932298228 2.88613993884985 4.92202870755617 5.3085725663737 5.41115659166869 2.12837020862179 5.21391928853285 -1.29261913514911 4.63262726440336e-08 7.59069453081767e-07 DOWN ENSG00000154265 ABCA5 ATP binding cassette subfamily A member 5 [Source:HGNC Symbol;Acc:HGNC:35] GO:0032502|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0048523|GO:0050794|GO:0043229|GO:0043167|GO:0097006|GO:0016043|GO:0043227|GO:0016787|GO:0031224|GO:0050793|GO:0005622|GO:0012505|GO:0031090|GO:0045595|GO:0006810|GO:0045596|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005774|GO:0005737|GO:0055085|GO:0034369|GO:0010008|GO:0000166|GO:0048869|GO:0016021|GO:0010876|GO:0005794|GO:0005768|GO:0016820|GO:0035639|GO:0001883|GO:0005773|GO:0016818|GO:0010743|GO:0032549|GO:0005770|GO:0006869|GO:0034375|GO:0000139|GO:0017076|GO:0030154|GO:0031902|GO:0010745|GO:0000323|GO:0005524|GO:0030554|GO:0015918|GO:0042626|GO:0016462|GO:0005765|GO:0005764|GO:0010742|GO:0017111|GO:0030301|GO:0016887|GO:0043691|GO:0033344|GO:0042623|GO:0043492 developmental process|transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|negative regulation of cellular process|regulation of cellular process|intracellular organelle|ion binding|regulation of plasma lipoprotein particle levels|cellular component organization|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|regulation of developmental process|intracellular|endomembrane system|organelle membrane|regulation of cell differentiation|transport|negative regulation of cell differentiation|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|transmembrane transport|plasma lipoprotein particle remodeling|endosome membrane|nucleotide binding|cellular developmental process|integral component of membrane|lipid localization|Golgi apparatus|endosome|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|purine ribonucleoside triphosphate binding|purine nucleoside binding|vacuole|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|regulation of macrophage derived foam cell differentiation|ribonucleoside binding|late endosome|lipid transport|high-density lipoprotein particle remodeling|Golgi membrane|purine nucleotide binding|cell differentiation|late endosome membrane|negative regulation of macrophage derived foam cell differentiation|lytic vacuole|ATP binding|adenyl nucleotide binding|sterol transport|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|lysosomal membrane|lysosome|macrophage derived foam cell differentiation|nucleoside-triphosphatase activity|cholesterol transport|ATPase activity|reverse cholesterol transport|cholesterol efflux|ATPase activity, coupled|ATPase activity, coupled to movement of substances K05648 ATP-binding cassette, subfamily A (ABC1), member 5[-] hsa02010 ABC transporters - Homo sapiens (human) 17:69244311-69327244 10 11 37 92 96 112 0.0392462758409616 0.0392382371152213 0.13093017531496 0.323522503755904 0.309143143360793 0.41196916163012 0.069804896090381 0.348211602915606 -2.31856414127171 4.63982105941767e-08 7.59831145956419e-07 DOWN ENSG00000213762 ZNF134 zinc finger protein 134 [Source:HGNC Symbol;Acc:HGNC:12918] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57614233-57624723 653 709 739 339 405 351 5.47094280303103 5.39852275242427 5.58222735769598 2.54475561699377 2.78401467909504 2.75603314157829 5.48389763771709 2.69493447922237 1.02495144427944 4.67995408602505e-08 7.65983274584384e-07 UP ENSG00000146909 NOM1 nucleolar protein with MIF4G domain 1 [Source:HGNC Symbol;Acc:HGNC:13244] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0007275|GO:0003676|GO:0043231|GO:0048869|GO:0022613|GO:0005730|GO:0003723|GO:0042254|GO:0031981|GO:0042274|GO:0007399|GO:0030154|GO:0005634|GO:0044822|GO:0022008 developmental process|cell|cellular process|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|multicellular organism development|nucleic acid binding|intracellular membrane-bounded organelle|cellular developmental process|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|ribosome biogenesis|nuclear lumen|ribosomal small subunit biogenesis|nervous system development|cell differentiation|nucleus|poly(A) RNA binding|neurogenesis - - - - 7:156949723-156973182 1538 1799 1631 876 965 724 10.1401114406183 10.779476984205 9.69515327601019 5.17473832187882 5.2201357198009 4.47356450528959 10.2049139002778 4.9561461823231 1.0419733645425 4.72613038496917e-08 7.73117241166409e-07 UP ENSG00000150459 SAP18 Sin3A associated protein 18kDa [Source:HGNC Symbol;Acc:HGNC:10530] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0010941|GO:0003676|GO:0034641|GO:0046483|GO:0010942|GO:0043231|GO:0005737|GO:0035145|GO:0009890|GO:0061574|GO:0006139|GO:0008219|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0003714|GO:0003723|GO:0010629|GO:0051252|GO:0006325|GO:0031981|GO:0005654|GO:0012501|GO:0010467|GO:0000118|GO:0009059|GO:0043068|GO:0016070|GO:0005634|GO:0043067|GO:0045814|GO:0043065|GO:0006396|GO:0050684|GO:0032774|GO:2001141|GO:0043484|GO:1902679|GO:0016604|GO:0040029|GO:0016071|GO:0042981|GO:0033119|GO:0044822|GO:0006351|GO:0006915|GO:0006355|GO:0016607|GO:0006366|GO:1903507|GO:0006357|GO:0048025|GO:1903506|GO:0048024|GO:0006397|GO:0008380|GO:0000375|GO:0000381|GO:0000398|GO:0000380 macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|exon-exon junction complex|negative regulation of biosynthetic process|ASAP complex|nucleobase-containing compound metabolic process|cell death|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|RNA binding|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|nuclear lumen|nucleoplasm|programmed cell death|gene expression|histone deacetylase complex|macromolecule biosynthetic process|positive regulation of programmed cell death|RNA metabolic process|nucleus|regulation of programmed cell death|negative regulation of gene expression, epigenetic|positive regulation of apoptotic process|RNA processing|regulation of mRNA processing|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of RNA splicing|negative regulation of RNA biosynthetic process|nuclear body|regulation of gene expression, epigenetic|mRNA metabolic process|regulation of apoptotic process|negative regulation of RNA splicing|poly(A) RNA binding|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|nuclear speck|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|negative regulation of mRNA splicing, via spliceosome|regulation of nucleic acid-templated transcription|regulation of mRNA splicing, via spliceosome|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|alternative mRNA splicing, via spliceosome K14324 histone deacetylase complex subunit SAP18[-] hsa03013|hsa03015 RNA transport - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human) 13:21140514-21149084 2200 2389 1822 1105 1124 899 22.6753695074156 22.3783444032496 16.9314595748352 10.2045026687764 9.50530073591425 8.68400988927745 20.6617244951668 9.4646044313227 1.12634655573634 4.734088370393e-08 7.73994929954614e-07 UP ENSG00000175197 DDIT3 DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0023051|GO:0000989|GO:0043227|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0032993|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0051282|GO:0045595|GO:0003712|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0001568|GO:0010941|GO:0009991|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0001817|GO:0051098|GO:0061061|GO:2000016|GO:0045786|GO:0043231|GO:0010243|GO:0005737|GO:0000981|GO:0007389|GO:0001816|GO:0005667|GO:0042592|GO:0009966|GO:0046983|GO:0048568|GO:0009890|GO:0019725|GO:0006979|GO:0001819|GO:0019904|GO:0042493|GO:0010646|GO:0006139|GO:0007154|GO:0044092|GO:0055085|GO:0007165|GO:1990622|GO:0009968|GO:0051649|GO:0008134|GO:2000021|GO:0008219|GO:0051238|GO:0048869|GO:0010035|GO:0009967|GO:0044249|GO:0045454|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0042594|GO:0005768|GO:0051090|GO:0007568|GO:0007584|GO:0000982|GO:1902533|GO:2001235|GO:0030111|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0030178|GO:0003714|GO:0051101|GO:0001955|GO:0007166|GO:0051100|GO:0030968|GO:0044798|GO:0001944|GO:0072358|GO:0030163|GO:0042542|GO:0010629|GO:0043620|GO:0006984|GO:0042692|GO:0046982|GO:0048878|GO:0009798|GO:0051252|GO:0008140|GO:1901216|GO:0070997|GO:0030275|GO:0044265|GO:0007050|GO:0009790|GO:0051208|GO:0010628|GO:0051147|GO:0045599|GO:0046907|GO:0006811|GO:1902235|GO:0051209|GO:0055082|GO:0032757|GO:0003002|GO:0006986|GO:0005770|GO:0031981|GO:0006508|GO:0005654|GO:0043433|GO:1901214|GO:0012501|GO:0000302|GO:0035556|GO:0044267|GO:0014075|GO:0010467|GO:0071310|GO:1902532|GO:0045598|GO:0031328|GO:0006983|GO:0009059|GO:0030154|GO:0001228|GO:0043068|GO:0035967|GO:1902531|GO:0016070|GO:0072359|GO:0031667|GO:0034976|GO:0010557|GO:0005634|GO:0051148|GO:0043067|GO:0006974|GO:0097190|GO:0032637|GO:0034220|GO:0034620|GO:0070059|GO:0051896|GO:0016055|GO:0043491|GO:0044257|GO:0000975|GO:0045893|GO:0097193|GO:0098655|GO:0045444|GO:2001242|GO:0051898|GO:2000677|GO:0090090|GO:0045445|GO:0043065|GO:0010498|GO:2001244|GO:0060828|GO:0045892|GO:0043523|GO:0032774|GO:0043565|GO:0006812|GO:2001141|GO:0001077|GO:0043525|GO:1902237|GO:1902679|GO:0060402|GO:0045661|GO:0036500|GO:0036499|GO:0003690|GO:0051603|GO:0009948|GO:0009855|GO:0009953|GO:0001975|GO:0042981|GO:0009952|GO:0050801|GO:0043522|GO:0032792|GO:1990440|GO:0051402|GO:0090575|GO:0045662|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0043618|GO:0043392|GO:0036488|GO:0009299|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:0019941|GO:1903506|GO:0044212|GO:0060070|GO:0036003|GO:0048263|GO:1990617|GO:0035976|GO:0030001|GO:0044324|GO:0000122|GO:2000678|GO:0030003|GO:1903025|GO:0043161|GO:0006511|GO:0070588|GO:0042789|GO:0000976|GO:0055065|GO:0001012|GO:0097553|GO:1903026|GO:0006875|GO:0001159|GO:0006874|GO:0006816|GO:0000977|GO:0000987|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0000978|GO:0007204 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|regulation of signaling|transcription factor activity, transcription factor binding|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|protein-DNA complex|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|regulation of sequestering of calcium ion|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to extracellular stimulus|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|regulation of cytokine production|regulation of binding|muscle structure development|negative regulation of determination of dorsal identity|negative regulation of cell cycle|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|cytokine production|transcription factor complex|homeostatic process|regulation of signal transduction|protein dimerization activity|embryonic organ development|negative regulation of biosynthetic process|cellular homeostasis|response to oxidative stress|positive regulation of cytokine production|protein domain specific binding|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|negative regulation of molecular function|transmembrane transport|signal transduction|CHOP-ATF3 complex|negative regulation of signal transduction|establishment of localization in cell|transcription factor binding|regulation of ion homeostasis|cell death|sequestering of metal ion|cellular developmental process|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|cell redox homeostasis|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to starvation|endosome|regulation of sequence-specific DNA binding transcription factor activity|aging|response to nutrient|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of Wnt signaling pathway|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|transcription corepressor activity|regulation of DNA binding|blood vessel maturation|cell surface receptor signaling pathway|negative regulation of binding|endoplasmic reticulum unfolded protein response|nuclear transcription factor complex|vasculature development|cardiovascular system development|protein catabolic process|response to hydrogen peroxide|negative regulation of gene expression|regulation of DNA-templated transcription in response to stress|ER-nucleus signaling pathway|muscle cell differentiation|protein heterodimerization activity|chemical homeostasis|axis specification|regulation of RNA metabolic process|cAMP response element binding protein binding|positive regulation of neuron death|neuron death|LRR domain binding|cellular macromolecule catabolic process|cell cycle arrest|embryo development|sequestering of calcium ion|positive regulation of gene expression|regulation of muscle cell differentiation|negative regulation of fat cell differentiation|intracellular transport|ion transport|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|positive regulation of interleukin-8 production|regionalization|response to unfolded protein|late endosome|nuclear lumen|proteolysis|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of neuron death|programmed cell death|response to reactive oxygen species|intracellular signal transduction|cellular protein metabolic process|response to amine|gene expression|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|ER overload response|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of programmed cell death|cellular response to topologically incorrect protein|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|response to nutrient levels|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|nucleus|negative regulation of muscle cell differentiation|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|interleukin-8 production|ion transmembrane transport|cellular response to unfolded protein|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|regulation of protein kinase B signaling|Wnt signaling pathway|protein kinase B signaling|cellular protein catabolic process|regulatory region DNA binding|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|cation transmembrane transport|fat cell differentiation|regulation of intrinsic apoptotic signaling pathway|negative regulation of protein kinase B signaling|regulation of transcription regulatory region DNA binding|negative regulation of canonical Wnt signaling pathway|myoblast differentiation|positive regulation of apoptotic process|proteasomal protein catabolic process|positive regulation of intrinsic apoptotic signaling pathway|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|RNA biosynthetic process|sequence-specific DNA binding|cation transport|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of neuron apoptotic process|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of RNA biosynthetic process|calcium ion transport into cytosol|regulation of myoblast differentiation|ATF6-mediated unfolded protein response|PERK-mediated unfolded protein response|double-stranded DNA binding|proteolysis involved in cellular protein catabolic process|anterior/posterior axis specification|determination of bilateral symmetry|dorsal/ventral pattern formation|response to amphetamine|regulation of apoptotic process|anterior/posterior pattern specification|ion homeostasis|leucine zipper domain binding|negative regulation of CREB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|neuron apoptotic process|RNA polymerase II transcription factor complex|negative regulation of myoblast differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of transcription from RNA polymerase II promoter in response to stress|negative regulation of DNA binding|CHOP-C/EBP complex|mRNA transcription|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|canonical Wnt signaling pathway|positive regulation of transcription from RNA polymerase II promoter in response to stress|determination of dorsal identity|CHOP-ATF4 complex|AP1 complex|metal ion transport|regulation of transcription involved in anterior/posterior axis specification|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|cellular cation homeostasis|regulation of RNA polymerase II regulatory region sequence-specific DNA binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|calcium ion transmembrane transport|mRNA transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|metal ion homeostasis|RNA polymerase II regulatory region DNA binding|calcium ion transmembrane import into cytosol|negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding|cellular metal ion homeostasis|core promoter proximal region DNA binding|cellular calcium ion homeostasis|calcium ion transport|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|RNA polymerase II core promoter proximal region sequence-specific DNA binding|positive regulation of cytosolic calcium ion concentration K04452 DNA damage-inducible transcript 3[-] hsa04010|hsa05202|hsa04141|hsa04932|hsa04210 MAPK signaling pathway - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Apoptosis - Homo sapiens (human) 12:57516588-57520517 290 281 156 72 89 69 3.41552795675199 3.00778593221385 1.65652832468737 0.759789069475193 0.86004306422709 0.761618475701925 2.6932807378844 0.793816869801403 1.76248649179919 4.77215470062918e-08 7.797914966206e-07 UP ENSG00000109445 ZNF330 zinc finger protein 330 [Source:HGNC Symbol;Acc:HGNC:15462] GO:0005623|GO:0005488|GO:0030496|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0043231|GO:0043169|GO:0005730|GO:0046872|GO:0031981|GO:0005694|GO:0005634|GO:0046914|GO:0000775|GO:0008270 cell|binding|midbody|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cation binding|nucleolus|metal ion binding|nuclear lumen|chromosome|nucleus|transition metal ion binding|chromosome, centromeric region|zinc ion binding - - - - 4:141220887-141234697 580 618 652 334 315 283 9.46858713996163 9.16907766770844 9.59663557078177 4.88541414039933 4.219250446715 4.32983914023944 9.41143345948395 4.47816790911792 1.07150585406918 4.7891298327356e-08 7.82137210210551e-07 UP ENSG00000130803 ZNF317 zinc finger protein 317 [Source:HGNC Symbol;Acc:HGNC:13507] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:9140380-9163424 969 1019 844 482 518 433 4.76000251061066 4.5492258397601 3.7380051506804 2.12142674063206 2.08776325193628 1.99342528491822 4.34907783368372 2.06753842582885 1.07279538579087 4.79805527712256e-08 7.83166442007748e-07 UP ENSG00000106526 ACTR3C ARP3 actin-related protein 3 homolog C (yeast) [Source:HGNC Symbol;Acc:HGNC:37282] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:0036094|GO:1903561|GO:0097159|GO:0050794|GO:0043229|GO:0044089|GO:0043167|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0051130|GO:0032535|GO:0043168|GO:0001882|GO:0031982|GO:0051128|GO:0022607|GO:0032970|GO:0005885|GO:0070062|GO:0008092|GO:0000166|GO:0030029|GO:0031334|GO:0043254|GO:0006996|GO:0032956|GO:0035639|GO:0007010|GO:0001883|GO:0003779|GO:0032549|GO:0006461|GO:0030036|GO:0032273|GO:0033043|GO:0017076|GO:0030832|GO:0005856|GO:0010638|GO:0015629|GO:0034622|GO:0030838|GO:0005524|GO:0043623|GO:0030554|GO:0008064|GO:0051493|GO:0007015|GO:0051495|GO:0030833|GO:0051258|GO:0045010|GO:0008154|GO:0034314|GO:0030041 macromolecular complex|cell|cellular process|extracellular region|binding|small molecule binding|extracellular vesicle|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|ion binding|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|positive regulation of cellular component organization|regulation of cellular component size|anion binding|nucleoside binding|vesicle|regulation of cellular component organization|cellular component assembly|regulation of actin filament-based process|Arp2/3 protein complex|extracellular exosome|cytoskeletal protein binding|nucleotide binding|actin filament-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|organelle organization|regulation of actin cytoskeleton organization|purine ribonucleoside triphosphate binding|cytoskeleton organization|purine nucleoside binding|actin binding|ribonucleoside binding|protein complex assembly|actin cytoskeleton organization|positive regulation of protein polymerization|regulation of organelle organization|purine nucleotide binding|regulation of actin filament length|cytoskeleton|positive regulation of organelle organization|actin cytoskeleton|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|ATP binding|cellular protein complex assembly|adenyl nucleotide binding|regulation of actin polymerization or depolymerization|regulation of cytoskeleton organization|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|protein polymerization|actin nucleation|actin polymerization or depolymerization|Arp2/3 complex-mediated actin nucleation|actin filament polymerization - - - - 7:150243916-150323725 12 34 25 104 88 125 0.0683579494545723 0.176016127451149 0.128395709916329 0.530795322634456 0.411286472553032 0.667319691050957 0.12425659560735 0.536467162079482 -2.1101674314086 4.81464376716054e-08 7.85444672266726e-07 DOWN ENSG00000261786 RP4-555D20.2 - - - - - - - 3:44117299-44122365 174 201 282 661 671 465 2.42909735573728 2.55018317397885 3.54942637154076 8.26787071508718 7.68573685400805 6.08382672625045 2.84290230041896 7.34581143178189 -1.36955734231364 4.84112688177763e-08 7.89333707966081e-07 DOWN ENSG00000235884 LINC00941 long intergenic non-protein coding RNA 941 [Source:HGNC Symbol;Acc:HGNC:48635] - - - - - - 12:30795681-30802711 40 47 31 164 165 115 0.95429175036236 1.01906698899634 0.666808174610877 3.50561188413513 3.2297827776202 2.57128092848 0.880055637989859 3.10222519674511 -1.81763677794363 4.89446623073632e-08 7.97594950067698e-07 DOWN ENSG00000136930 PSMB7 proteasome subunit beta 7 [Source:HGNC Symbol;Acc:HGNC:9544] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0019882|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0016787|GO:0002684|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0060341|GO:0002757|GO:0051726|GO:0007049|GO:0006935|GO:0045087|GO:0048468|GO:0019884|GO:0006810|GO:0022402|GO:0051130|GO:0010941|GO:0006082|GO:0007275|GO:0034641|GO:0044281|GO:0006952|GO:0031982|GO:0031325|GO:0051128|GO:0033554|GO:0045786|GO:0043231|GO:0008233|GO:0010243|GO:0005839|GO:0005737|GO:0006520|GO:0002218|GO:0032880|GO:0051222|GO:0006928|GO:0009966|GO:0000502|GO:0045184|GO:0045787|GO:0060548|GO:0032388|GO:0010646|GO:0043085|GO:0050776|GO:0008104|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0009968|GO:0070062|GO:0042180|GO:0051649|GO:0009725|GO:0008219|GO:0090316|GO:0050790|GO:0048002|GO:0030030|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0043487|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0030111|GO:0000902|GO:0005829|GO:0045732|GO:0031175|GO:0010468|GO:0000075|GO:0030178|GO:0090068|GO:0007166|GO:1903047|GO:0043412|GO:0072594|GO:0002758|GO:0034097|GO:0030163|GO:0007005|GO:0043069|GO:0009308|GO:0032386|GO:0044770|GO:0051223|GO:1903955|GO:0015031|GO:0044265|GO:1901652|GO:0007050|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0070201|GO:0046907|GO:0006521|GO:0002429|GO:0031981|GO:0051351|GO:0007346|GO:0043434|GO:0044344|GO:0010564|GO:0051247|GO:0045930|GO:0070848|GO:0006508|GO:0005654|GO:0002764|GO:0002474|GO:0034613|GO:0010565|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0042176|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0006626|GO:0051246|GO:0030177|GO:0030154|GO:0048858|GO:0072395|GO:1903827|GO:1902531|GO:0032870|GO:0005634|GO:0043067|GO:0045089|GO:0006974|GO:0045088|GO:0043488|GO:0010948|GO:0010638|GO:0048666|GO:0030182|GO:0007411|GO:0016055|GO:0044257|GO:0019221|GO:0033365|GO:0042590|GO:0033157|GO:0031401|GO:0008543|GO:0090090|GO:0071156|GO:0010498|GO:0051436|GO:1901653|GO:0043408|GO:0060828|GO:0007093|GO:0072331|GO:0042770|GO:0038061|GO:1903364|GO:0044772|GO:0006839|GO:0030162|GO:0051444|GO:0045862|GO:0051439|GO:0071363|GO:0016310|GO:0006605|GO:0072655|GO:0010608|GO:0002768|GO:0044774|GO:0038179|GO:0000077|GO:0010822|GO:0061564|GO:0016482|GO:1901990|GO:0006886|GO:0051603|GO:0007167|GO:0004175|GO:0010821|GO:0006576|GO:0071375|GO:0043410|GO:0042981|GO:0071345|GO:0043066|GO:0019752|GO:0032868|GO:1901987|GO:0051438|GO:0034612|GO:0051443|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050851|GO:0090263|GO:0048812|GO:1903214|GO:0043549|GO:0006915|GO:0044773|GO:1901991|GO:0071158|GO:0033674|GO:0048011|GO:1903533|GO:0000186|GO:2000045|GO:0007265|GO:0002223|GO:0045859|GO:1903052|GO:0045860|GO:0004298|GO:0007409|GO:0044819|GO:0019941|GO:0006468|GO:0048699|GO:0071356|GO:0060070|GO:0044783|GO:0043405|GO:0042325|GO:0002479|GO:0001932|GO:1902806|GO:0032869|GO:0038093|GO:2000134|GO:0000082|GO:0033209|GO:0001934|GO:0050852|GO:0031571|GO:0042327|GO:1902807|GO:0006977|GO:0030330|GO:0051437|GO:0043161|GO:0072422|GO:0070585|GO:0006595|GO:0007169|GO:0032446|GO:0048010|GO:0072431|GO:0006511|GO:0031398|GO:2000058|GO:0038095|GO:0031396|GO:0031397|GO:2000060|GO:0071900|GO:0032147|GO:0008286|GO:0031145|GO:0038127|GO:0007173|GO:0042787|GO:0016567|GO:0000209 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|antigen processing and presentation|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|positive regulation of immune system process|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|protein complex|anatomical structure development|regulation of metabolic process|viral process|regulation of cellular localization|immune response-activating signal transduction|regulation of cell cycle|cell cycle|chemotaxis|innate immune response|cell development|antigen processing and presentation of exogenous antigen|transport|cell cycle process|positive regulation of cellular component organization|regulation of cell death|organic acid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|peptidase activity|response to organonitrogen compound|proteasome core complex|cytoplasm|cellular amino acid metabolic process|activation of innate immune response|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|regulation of signal transduction|proteasome complex|establishment of protein localization|positive regulation of cell cycle|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|protein localization|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|negative regulation of signal transduction|extracellular exosome|cellular ketone metabolic process|establishment of localization in cell|response to hormone|cell death|positive regulation of intracellular protein transport|regulation of catalytic activity|antigen processing and presentation of peptide antigen|cell projection organization|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of RNA stability|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|positive regulation of protein catabolic process|neuron projection development|regulation of gene expression|cell cycle checkpoint|negative regulation of Wnt signaling pathway|positive regulation of cell cycle process|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|establishment of protein localization to organelle|innate immune response-activating signal transduction|response to cytokine|protein catabolic process|mitochondrion organization|negative regulation of programmed cell death|amine metabolic process|regulation of intracellular transport|cell cycle phase transition|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|cellular macromolecule catabolic process|response to peptide|cell cycle arrest|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of establishment of protein localization|intracellular transport|regulation of cellular amino acid metabolic process|immune response-activating cell surface receptor signaling pathway|nuclear lumen|positive regulation of ligase activity|regulation of mitotic cell cycle|response to peptide hormone|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|response to growth factor|proteolysis|nucleoplasm|immune response-regulating signaling pathway|antigen processing and presentation of peptide antigen via MHC class I|cellular protein localization|regulation of cellular ketone metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|protein targeting to mitochondrion|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|cell differentiation|cell projection morphogenesis|signal transduction involved in cell cycle checkpoint|regulation of cellular protein localization|regulation of intracellular signal transduction|cellular response to hormone stimulus|nucleus|regulation of programmed cell death|positive regulation of innate immune response|cellular response to DNA damage stimulus|regulation of innate immune response|regulation of mRNA stability|negative regulation of cell cycle process|positive regulation of organelle organization|neuron development|neuron differentiation|axon guidance|Wnt signaling pathway|cellular protein catabolic process|cytokine-mediated signaling pathway|protein localization to organelle|antigen processing and presentation of exogenous peptide antigen via MHC class I|regulation of intracellular protein transport|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of cell cycle arrest|proteasomal protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|cellular response to peptide|regulation of MAPK cascade|regulation of canonical Wnt signaling pathway|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|NIK/NF-kappaB signaling|positive regulation of cellular protein catabolic process|mitotic cell cycle phase transition|mitochondrial transport|regulation of proteolysis|negative regulation of ubiquitin-protein transferase activity|positive regulation of proteolysis|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|cellular response to growth factor stimulus|phosphorylation|protein targeting|establishment of protein localization to mitochondrion|posttranscriptional regulation of gene expression|immune response-regulating cell surface receptor signaling pathway|mitotic DNA integrity checkpoint|neurotrophin signaling pathway|DNA damage checkpoint|positive regulation of mitochondrion organization|axon development|cytosolic transport|regulation of mitotic cell cycle phase transition|intracellular protein transport|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|endopeptidase activity|regulation of mitochondrion organization|cellular biogenic amine metabolic process|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|carboxylic acid metabolic process|response to insulin|regulation of cell cycle phase transition|regulation of ubiquitin-protein transferase activity|response to tumor necrosis factor|positive regulation of ubiquitin-protein transferase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|antigen receptor-mediated signaling pathway|positive regulation of canonical Wnt signaling pathway|neuron projection morphogenesis|regulation of protein targeting to mitochondrion|regulation of kinase activity|apoptotic process|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|regulation of protein targeting|activation of MAPKK activity|regulation of G1/S transition of mitotic cell cycle|Ras protein signal transduction|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|positive regulation of proteolysis involved in cellular protein catabolic process|positive regulation of protein kinase activity|threonine-type endopeptidase activity|axonogenesis|mitotic G1/S transition checkpoint|modification-dependent protein catabolic process|protein phosphorylation|generation of neurons|cellular response to tumor necrosis factor|canonical Wnt signaling pathway|G1 DNA damage checkpoint|regulation of MAP kinase activity|regulation of phosphorylation|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|cellular response to insulin stimulus|Fc receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|tumor necrosis factor-mediated signaling pathway|positive regulation of protein phosphorylation|T cell receptor signaling pathway|mitotic G1 DNA damage checkpoint|positive regulation of phosphorylation|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|proteasome-mediated ubiquitin-dependent protein catabolic process|signal transduction involved in DNA damage checkpoint|protein localization to mitochondrion|polyamine metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|signal transduction involved in mitotic G1 DNA damage checkpoint|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Fc-epsilon receptor signaling pathway|regulation of protein ubiquitination|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination K02739 20S proteasome subunit beta 2[3.4.25.1] hsa03050 Proteasome - Homo sapiens (human) 9:124353466-124415444 1187 1492 1361 3651 3809 2597 34.3273162244409 39.2137270648418 35.4863829508082 94.6016772300858 90.3791490653516 70.3866432495124 36.3424754133636 85.1224898483166 -1.2278836606147 4.95520138143324e-08 8.07051729630704e-07 DOWN ENSG00000160746 ANO10 anoctamin 10 [Source:HGNC Symbol;Acc:HGNC:25519] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0006810|GO:0022891|GO:0055085|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0034220|GO:0098655|GO:0006820|GO:0005216|GO:0098656|GO:0008509|GO:0006812|GO:0008324|GO:0005253|GO:0005261|GO:0022839|GO:0015698|GO:0005254|GO:1902476|GO:0006821|GO:0005227|GO:0005229|GO:0015108 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|transport|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|anion transport|ion channel activity|anion transmembrane transport|anion transmembrane transporter activity|cation transport|cation transmembrane transporter activity|anion channel activity|cation channel activity|ion gated channel activity|inorganic anion transport|chloride channel activity|chloride transmembrane transport|chloride transport|calcium activated cation channel activity|intracellular calcium activated chloride channel activity|chloride transmembrane transporter activity - - - - 3:43354859-43691594 89 118 193 382 400 419 0.64662954772563 0.779159988222083 1.26426290753635 2.48671447812801 2.38447967971697 2.85303847925571 0.896684147828021 2.5747442123669 -1.52175731689743 4.96453910246851e-08 8.08131681380016e-07 DOWN ENSG00000185049 NELFA negative elongation factor complex member A [Source:HGNC Symbol;Acc:HGNC:12768] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0032259|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0008023|GO:0006725|GO:0051130|GO:1901360|GO:0007275|GO:0016570|GO:0034641|GO:0048524|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0005737|GO:0009890|GO:0003682|GO:0006139|GO:0044249|GO:0019538|GO:0050792|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0010468|GO:0034645|GO:0043412|GO:0010629|GO:0031056|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0031058|GO:0010628|GO:0036211|GO:0032021|GO:0019083|GO:0031981|GO:0051247|GO:0005654|GO:0032270|GO:0033043|GO:0044267|GO:1903902|GO:0010467|GO:0019058|GO:0031328|GO:0051246|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0010638|GO:2001252|GO:0031062|GO:0045893|GO:0031401|GO:0045892|GO:0046782|GO:0032774|GO:2001141|GO:0033044|GO:1902679|GO:0031060|GO:0018022|GO:0034968|GO:0016568|GO:0050434|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0032784|GO:1903507|GO:0032785|GO:0006357|GO:0051568|GO:1903506|GO:0006354|GO:0051571|GO:0018193|GO:0051569|GO:0000122|GO:0006368|GO:0034243|GO:0034244|GO:0018205 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|methylation|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|viral process|transcription elongation factor complex|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|histone modification|cellular nitrogen compound metabolic process|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of viral process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|negative regulation of gene expression|regulation of histone modification|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|positive regulation of histone modification|positive regulation of gene expression|protein modification process|NELF complex|viral transcription|nuclear lumen|positive regulation of protein metabolic process|nucleoplasm|positive regulation of cellular protein metabolic process|regulation of organelle organization|cellular protein metabolic process|positive regulation of viral life cycle|gene expression|viral life cycle|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of organelle organization|positive regulation of chromosome organization|positive regulation of histone methylation|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|negative regulation of transcription, DNA-templated|regulation of viral transcription|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of chromosome organization|negative regulation of RNA biosynthetic process|regulation of histone methylation|peptidyl-lysine methylation|histone lysine methylation|chromatin modification|positive regulation of viral transcription|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|negative regulation of nucleic acid-templated transcription|negative regulation of DNA-templated transcription, elongation|regulation of transcription from RNA polymerase II promoter|histone H3-K4 methylation|regulation of nucleic acid-templated transcription|DNA-templated transcription, elongation|positive regulation of histone H3-K4 methylation|peptidyl-amino acid modification|regulation of histone H3-K4 methylation|negative regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter|peptidyl-lysine modification - - - - 4:1982714-2041903 1195 929 1411 451 659 579 7.32183198350079 5.1730614902927 7.79458309231746 2.4758571410477 3.31287661455099 3.32475025662417 6.76315885537032 3.03782800407429 1.15465705111045 5.01337641596066e-08 8.15636727640814e-07 UP ENSG00000136861 CDK5RAP2 CDK5 regulatory subunit associated protein 2 [Source:HGNC Symbol;Acc:HGNC:18672] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0005488|GO:1903561|GO:0097159|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0045595|GO:0006725|GO:0051640|GO:0048468|GO:1902115|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0005874|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0022607|GO:0045786|GO:0043231|GO:0019899|GO:0005737|GO:0032886|GO:0060322|GO:0032403|GO:0051656|GO:0006139|GO:0005516|GO:0007163|GO:0070062|GO:0051649|GO:0008092|GO:0007059|GO:0048869|GO:0016021|GO:0044249|GO:0007017|GO:0031323|GO:0005794|GO:0006996|GO:0050768|GO:0031023|GO:0015631|GO:0005829|GO:0051653|GO:0003677|GO:0005813|GO:0010468|GO:0000075|GO:0034645|GO:1903047|GO:0007010|GO:0007417|GO:0070507|GO:0051252|GO:0005815|GO:0044770|GO:0010721|GO:0007098|GO:0098534|GO:0008017|GO:0010628|GO:0000278|GO:0046599|GO:0030010|GO:0010564|GO:0007099|GO:0048471|GO:0051293|GO:0070925|GO:0019900|GO:0033043|GO:0010467|GO:0051298|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0000226|GO:0005856|GO:0010557|GO:0000922|GO:0005819|GO:0051960|GO:0010948|GO:0046600|GO:0030182|GO:0031577|GO:0000975|GO:0045893|GO:0072686|GO:0010826|GO:0000086|GO:0051294|GO:0032774|GO:0044772|GO:2001141|GO:0051494|GO:0051493|GO:0097431|GO:0015630|GO:0051297|GO:0040001|GO:0001578|GO:0000132|GO:0010824|GO:0045665|GO:0046605|GO:0019901|GO:0022008|GO:0000242|GO:0050767|GO:0006351|GO:0006355|GO:1901976|GO:0090231|GO:0048699|GO:1903506|GO:0044212|GO:0045664 developmental process|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|binding|extracellular vesicle|organic cyclic compound binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|regulation of cell differentiation|cellular aromatic compound metabolic process|organelle localization|cell development|regulation of organelle assembly|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|microtubule|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|cellular component assembly|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of microtubule-based process|head development|protein complex binding|establishment of organelle localization|nucleobase-containing compound metabolic process|calmodulin binding|establishment or maintenance of cell polarity|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|chromosome segregation|cellular developmental process|integral component of membrane|cellular biosynthetic process|microtubule-based process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|negative regulation of neurogenesis|microtubule organizing center organization|tubulin binding|cytosol|spindle localization|DNA binding|centrosome|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|mitotic cell cycle process|cytoskeleton organization|central nervous system development|regulation of microtubule cytoskeleton organization|regulation of RNA metabolic process|microtubule organizing center|cell cycle phase transition|negative regulation of cell development|centrosome cycle|centriole assembly|microtubule binding|positive regulation of gene expression|mitotic cell cycle|regulation of centriole replication|establishment of cell polarity|regulation of cell cycle process|centriole replication|perinuclear region of cytoplasm|establishment of spindle localization|organelle assembly|kinase binding|regulation of organelle organization|gene expression|centrosome duplication|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|microtubule cytoskeleton organization|cytoskeleton|positive regulation of macromolecule biosynthetic process|spindle pole|spindle|regulation of nervous system development|negative regulation of cell cycle process|negative regulation of centriole replication|neuron differentiation|spindle checkpoint|regulatory region DNA binding|positive regulation of transcription, DNA-templated|mitotic spindle|negative regulation of centrosome duplication|G2/M transition of mitotic cell cycle|establishment of spindle orientation|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|mitotic spindle pole|microtubule cytoskeleton|centrosome organization|establishment of mitotic spindle localization|microtubule bundle formation|establishment of mitotic spindle orientation|regulation of centrosome duplication|negative regulation of neuron differentiation|regulation of centrosome cycle|protein kinase binding|neurogenesis|pericentriolar material|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of cell cycle checkpoint|regulation of spindle checkpoint|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of neuron differentiation - - - - 9:120388869-120580170 637 759 998 1740 2002 1850 3.07761538268366 3.33270634191567 4.34730053847938 7.53220167198919 7.93609882519938 8.37675033128653 3.5858740876929 7.94835027615837 -1.14833062103551 5.08579187859307e-08 8.26967487709791e-07 DOWN ENSG00000177606 JUN jun proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6204] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044089|GO:0007623|GO:0071704|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0000989|GO:0040017|GO:0009653|GO:0000785|GO:0016043|GO:0051707|GO:0043227|GO:0044708|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0016032|GO:0048514|GO:0007507|GO:0008284|GO:0051272|GO:0002757|GO:0051726|GO:0042127|GO:0007049|GO:1903706|GO:0000791|GO:0042391|GO:0045087|GO:0045595|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0009314|GO:0006810|GO:0051130|GO:0009612|GO:1901360|GO:0001568|GO:0010941|GO:0009991|GO:0007275|GO:0010632|GO:0051702|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0008047|GO:0006952|GO:0048524|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0022607|GO:0010942|GO:0051098|GO:0045597|GO:0043231|GO:0046332|GO:0019899|GO:0010243|GO:0048144|GO:0005737|GO:0000981|GO:0002218|GO:0031668|GO:0009611|GO:0001076|GO:0017053|GO:0007423|GO:0071559|GO:0006928|GO:0009887|GO:0005667|GO:0001775|GO:0009966|GO:0046983|GO:0050673|GO:0045184|GO:0009890|GO:0003682|GO:0006979|GO:0019904|GO:0060548|GO:0042493|GO:0010646|GO:0006139|GO:0043085|GO:0009617|GO:0050776|GO:0001525|GO:0000790|GO:0008104|GO:0007154|GO:0044092|GO:0051270|GO:0061029|GO:0016477|GO:0007165|GO:0050778|GO:0003151|GO:0051649|GO:0008134|GO:0009725|GO:0048525|GO:0008219|GO:0007611|GO:0010634|GO:0008285|GO:0050790|GO:0030030|GO:0048869|GO:2000145|GO:0010035|GO:0009967|GO:0044249|GO:0019538|GO:0031334|GO:0043254|GO:0023014|GO:0050792|GO:0010033|GO:0031324|GO:0031323|GO:0048732|GO:0042594|GO:0006996|GO:0051090|GO:0007568|GO:0003713|GO:0000165|GO:0050679|GO:0000982|GO:1902533|GO:0032268|GO:0005829|GO:0031175|GO:0003677|GO:0010468|GO:0090132|GO:0034645|GO:0048660|GO:1901215|GO:0005096|GO:0051101|GO:0003723|GO:0007166|GO:0001654|GO:0014074|GO:0051100|GO:0051899|GO:0033993|GO:0031102|GO:0001944|GO:0043412|GO:0072594|GO:0030097|GO:0002758|GO:0072358|GO:0034097|GO:0001085|GO:0051345|GO:0042542|GO:0007612|GO:0010629|GO:0002237|GO:0043620|GO:0007005|GO:0043069|GO:0048678|GO:0046982|GO:0030695|GO:0051252|GO:0046683|GO:2000144|GO:1901216|GO:0003007|GO:0071837|GO:0070997|GO:0015031|GO:0048659|GO:0001889|GO:0010628|GO:0010038|GO:0030334|GO:0001935|GO:0001667|GO:0048661|GO:0036211|GO:0032269|GO:0071560|GO:0046907|GO:0003705|GO:0019083|GO:0048145|GO:0031981|GO:0031098|GO:0035994|GO:0051247|GO:0048146|GO:0070848|GO:0005654|GO:0006259|GO:0051591|GO:0050678|GO:0005694|GO:0002764|GO:0000228|GO:0009267|GO:0006461|GO:1901214|GO:0042116|GO:0034613|GO:2000142|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0000302|GO:0051054|GO:0006796|GO:0035556|GO:0071241|GO:0044267|GO:1903902|GO:0051174|GO:0010467|GO:0017038|GO:0045639|GO:0007399|GO:0019058|GO:0071310|GO:0060395|GO:0050890|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0001228|GO:0070412|GO:0005719|GO:0030335|GO:0043068|GO:0031669|GO:0001191|GO:1902531|GO:0016070|GO:0072359|GO:0031667|GO:0034976|GO:0033613|GO:0032870|GO:0010557|GO:0032496|GO:0005634|GO:0042803|GO:0043067|GO:0045089|GO:0006606|GO:0045637|GO:0097190|GO:0045088|GO:0048666|GO:0030182|GO:0002521|GO:0002761|GO:0000975|GO:0045893|GO:1990441|GO:0001102|GO:0033365|GO:0001774|GO:0031401|GO:0006260|GO:0051365|GO:0043065|GO:0051169|GO:0030855|GO:0043408|GO:0045892|GO:0043010|GO:0043523|GO:0046782|GO:0032774|GO:0043565|GO:0051592|GO:2001141|GO:0008637|GO:0001077|GO:0043525|GO:0071363|GO:0043087|GO:0016310|GO:0006605|GO:0002768|GO:1902679|GO:0070371|GO:0002221|GO:0007179|GO:0003690|GO:0061564|GO:0001936|GO:0006886|GO:0043547|GO:0007167|GO:0002763|GO:0043410|GO:0006275|GO:0001836|GO:0010631|GO:0042981|GO:0032897|GO:0043066|GO:0001938|GO:0044822|GO:0051402|GO:0030099|GO:0043524|GO:0045740|GO:0050434|GO:0022008|GO:0006464|GO:0031103|GO:0007184|GO:0051403|GO:0006351|GO:0006915|GO:0006355|GO:0043618|GO:0071248|GO:0043392|GO:0045944|GO:0006366|GO:0002573|GO:0006913|GO:0097201|GO:1903507|GO:0002224|GO:0006352|GO:0006357|GO:0006468|GO:0048699|GO:0043923|GO:0071277|GO:1903506|GO:0044212|GO:0035026|GO:0045657|GO:0001190|GO:0042325|GO:0045655|GO:0070374|GO:0001932|GO:0042326|GO:0038093|GO:0001934|GO:0007178|GO:0001933|GO:0000122|GO:0043922|GO:0070372|GO:0042327|GO:0034504|GO:0051170|GO:0035326|GO:0035497|GO:0034166|GO:0034134|GO:0038124|GO:0030224|GO:0000976|GO:0001012|GO:0046777|GO:0038095|GO:0031952|GO:0002756|GO:1902895|GO:0031953|GO:0034138|GO:0002755|GO:0034146|GO:0001159|GO:0034142|GO:0038123|GO:0034162|GO:0000977|GO:0000987|GO:0001158|GO:0035666|GO:0000980|GO:0000978 locomotion|developmental process|macromolecular complex|immune system process|behavior|signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|circadian rhythm|organic substance metabolic process|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|positive regulation of locomotion|anatomical structure morphogenesis|chromatin|cellular component organization|response to other organism|membrane-bounded organelle|single-organism behavior|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|viral process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|positive regulation of cellular component movement|immune response-activating signal transduction|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of hemopoiesis|euchromatin|regulation of membrane potential|innate immune response|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|response to radiation|transport|positive regulation of cellular component organization|response to mechanical stimulus|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to extracellular stimulus|multicellular organism development|regulation of epithelial cell migration|interaction with symbiont|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|enzyme activator activity|defense response|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|cellular component assembly|positive regulation of cell death|regulation of binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|SMAD binding|enzyme binding|response to organonitrogen compound|fibroblast proliferation|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|cellular response to extracellular stimulus|response to wounding|transcription factor activity, RNA polymerase II transcription factor binding|transcriptional repressor complex|sensory organ development|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|transcription factor complex|cell activation|regulation of signal transduction|protein dimerization activity|epithelial cell proliferation|establishment of protein localization|negative regulation of biosynthetic process|chromatin binding|response to oxidative stress|protein domain specific binding|negative regulation of cell death|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|regulation of immune response|angiogenesis|nuclear chromatin|protein localization|cell communication|negative regulation of molecular function|regulation of cellular component movement|eyelid development in camera-type eye|cell migration|signal transduction|positive regulation of immune response|outflow tract morphogenesis|establishment of localization in cell|transcription factor binding|response to hormone|negative regulation of viral process|cell death|learning or memory|positive regulation of epithelial cell migration|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|cellular developmental process|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|signal transduction by protein phosphorylation|regulation of viral process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|response to starvation|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|aging|transcription coactivator activity|MAPK cascade|positive regulation of epithelial cell proliferation|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|neuron projection development|DNA binding|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|negative regulation of neuron death|GTPase activator activity|regulation of DNA binding|RNA binding|cell surface receptor signaling pathway|eye development|response to purine-containing compound|negative regulation of binding|membrane depolarization|response to lipid|neuron projection regeneration|vasculature development|macromolecule modification|establishment of protein localization to organelle|hemopoiesis|innate immune response-activating signal transduction|cardiovascular system development|response to cytokine|RNA polymerase II transcription factor binding|positive regulation of hydrolase activity|response to hydrogen peroxide|learning|negative regulation of gene expression|response to molecule of bacterial origin|regulation of DNA-templated transcription in response to stress|mitochondrion organization|negative regulation of programmed cell death|response to axon injury|protein heterodimerization activity|GTPase regulator activity|regulation of RNA metabolic process|response to organophosphorus|positive regulation of DNA-templated transcription, initiation|positive regulation of neuron death|heart morphogenesis|HMG box domain binding|neuron death|protein transport|smooth muscle cell proliferation|liver development|positive regulation of gene expression|response to metal ion|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|positive regulation of smooth muscle cell proliferation|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|intracellular transport|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|viral transcription|regulation of fibroblast proliferation|nuclear lumen|stress-activated protein kinase signaling cascade|response to muscle stretch|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|response to growth factor|nucleoplasm|DNA metabolic process|response to cAMP|regulation of epithelial cell proliferation|chromosome|immune response-regulating signaling pathway|nuclear chromosome|cellular response to starvation|protein complex assembly|regulation of neuron death|macrophage activation|cellular protein localization|regulation of DNA-templated transcription, initiation|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|response to reactive oxygen species|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular response to inorganic substance|cellular protein metabolic process|positive regulation of viral life cycle|regulation of phosphorus metabolic process|gene expression|protein import|positive regulation of myeloid cell differentiation|nervous system development|viral life cycle|cellular response to organic substance|SMAD protein signal transduction|cognition|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|R-SMAD binding|nuclear euchromatin|positive regulation of cell migration|positive regulation of programmed cell death|cellular response to nutrient levels|transcriptional repressor activity, RNA polymerase II transcription factor binding|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|response to nutrient levels|response to endoplasmic reticulum stress|activating transcription factor binding|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|protein homodimerization activity|regulation of programmed cell death|positive regulation of innate immune response|protein import into nucleus|regulation of myeloid cell differentiation|apoptotic signaling pathway|regulation of innate immune response|neuron development|neuron differentiation|leukocyte differentiation|regulation of myeloid leukocyte differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress|RNA polymerase II activating transcription factor binding|protein localization to organelle|microglial cell activation|positive regulation of protein modification process|DNA replication|cellular response to potassium ion starvation|positive regulation of apoptotic process|nuclear transport|epithelial cell differentiation|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|camera-type eye development|regulation of neuron apoptotic process|regulation of viral transcription|RNA biosynthetic process|sequence-specific DNA binding|response to calcium ion|regulation of RNA biosynthetic process|apoptotic mitochondrial changes|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of neuron apoptotic process|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|protein targeting|immune response-regulating cell surface receptor signaling pathway|negative regulation of RNA biosynthetic process|ERK1 and ERK2 cascade|pattern recognition receptor signaling pathway|transforming growth factor beta receptor signaling pathway|double-stranded DNA binding|axon development|regulation of endothelial cell proliferation|intracellular protein transport|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|positive regulation of myeloid leukocyte differentiation|positive regulation of MAPK cascade|regulation of DNA replication|release of cytochrome c from mitochondria|epithelial cell migration|regulation of apoptotic process|negative regulation of viral transcription|negative regulation of apoptotic process|positive regulation of endothelial cell proliferation|poly(A) RNA binding|neuron apoptotic process|myeloid cell differentiation|negative regulation of neuron apoptotic process|positive regulation of DNA replication|positive regulation of viral transcription|neurogenesis|cellular protein modification process|axon regeneration|SMAD protein import into nucleus|stress-activated MAPK cascade|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|cellular response to metal ion|negative regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|myeloid leukocyte differentiation|nucleocytoplasmic transport|negative regulation of transcription from RNA polymerase II promoter in response to stress|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|generation of neurons|positive regulation by host of viral transcription|cellular response to calcium ion|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|leading edge cell differentiation|positive regulation of monocyte differentiation|transcriptional activator activity, RNA polymerase II transcription factor binding|regulation of phosphorylation|regulation of monocyte differentiation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|Fc receptor signaling pathway|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation by host of viral transcription|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|protein localization to nucleus|nuclear import|enhancer binding|cAMP response element binding|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|monocyte differentiation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|protein autophosphorylation|Fc-epsilon receptor signaling pathway|regulation of protein autophosphorylation|MyD88-independent toll-like receptor signaling pathway|positive regulation of pri-miRNA transcription from RNA polymerase II promoter|negative regulation of protein autophosphorylation|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|core promoter proximal region DNA binding|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|enhancer sequence-specific DNA binding|TRIF-dependent toll-like receptor signaling pathway|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K04448 transcription factor AP-1[-] hsa05200|hsa05166|hsa04010|hsa05203|hsa04510|hsa05169|hsa04024|hsa05168|hsa05164|hsa04921|hsa04932|hsa05161|hsa04310|hsa04210|hsa04380|hsa04722|hsa04668|hsa04620|hsa05142|hsa04660|hsa05231|hsa04933|hsa04915|hsa04912|hsa05323|hsa04012|hsa05132|hsa05133|hsa05140|hsa04662|hsa05120|hsa05031|hsa05211|hsa05321|hsa05210|hsa05030 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Renal cell carcinoma - Homo sapiens (human)|Inflammatory bowel disease (IBD) - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human) 1:58780788-58784327 1478 1538 1549 796 902 701 29.5336279905812 27.930506298373 27.9066759127939 14.2512507015015 14.7882548238279 13.1277289265717 28.456936733916 14.0557448173004 1.01762046584375 5.11353104522138e-08 8.30573209053532e-07 UP ENSG00000258102 MAP1LC3B2 microtubule associated protein 1 light chain 3 beta 2 [Source:HGNC Symbol;Acc:HGNC:34390] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0043229|GO:0006950|GO:0009056|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0009991|GO:0005874|GO:0031982|GO:0033554|GO:0022607|GO:0043231|GO:0005774|GO:0005737|GO:0031668|GO:0032403|GO:0007154|GO:0000422|GO:0008092|GO:0016236|GO:0042594|GO:0006996|GO:0015631|GO:0005829|GO:1903008|GO:0031410|GO:0007005|GO:0005773|GO:0008017|GO:0000421|GO:0009267|GO:0070925|GO:0031669|GO:0000045|GO:0031667|GO:0005856|GO:0007033|GO:0006995|GO:0005776|GO:0015630 cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|intracellular organelle|response to stress|catabolic process|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|intracellular|protein binding|endomembrane system|organelle membrane|response to extracellular stimulus|microtubule|vesicle|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|cellular response to extracellular stimulus|protein complex binding|cell communication|mitophagy|cytoskeletal protein binding|macroautophagy|response to starvation|organelle organization|tubulin binding|cytosol|organelle disassembly|cytoplasmic vesicle|mitochondrion organization|vacuole|microtubule binding|autophagosome membrane|cellular response to starvation|organelle assembly|cellular response to nutrient levels|autophagosome assembly|response to nutrient levels|cytoskeleton|vacuole organization|cellular response to nitrogen starvation|autophagosome|microtubule cytoskeleton - - - - 12:116548105-116576448 308 317 278 107 145 133 9.94837045765676 9.30552748115201 8.0958133409179 3.09658758684436 3.8426969656385 4.02608785536207 9.11657042657556 3.65512413594831 1.31857079322914 5.11148795298139e-08 8.30573209053532e-07 UP ENSG00000146232 NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon [Source:HGNC Symbol;Acc:HGNC:7799] GO:0005623|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0051051|GO:0051641|GO:0043227|GO:1903828|GO:0005622|GO:0005515|GO:0012505|GO:0060341|GO:1900181|GO:0006810|GO:0043231|GO:0051651|GO:0005737|GO:0032880|GO:0045184|GO:0032387|GO:0008104|GO:0051649|GO:0090317|GO:0051224|GO:0005794|GO:0005829|GO:0042308|GO:0072594|GO:0032386|GO:0051223|GO:0015031|GO:0070201|GO:0046907|GO:0006811|GO:0032507|GO:0048471|GO:0034613|GO:0017038|GO:1903827|GO:0006606|GO:0051220|GO:1904589|GO:0006820|GO:0015711|GO:0033365|GO:0033157|GO:0051169|GO:0006812|GO:0006605|GO:0046942|GO:0016482|GO:0006886|GO:0042992|GO:0006865|GO:0042306|GO:1900180|GO:0042991|GO:1903533|GO:0015804|GO:0006913|GO:0042990|GO:0042994|GO:0034504|GO:0046822|GO:0042942|GO:0051170 cell|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|negative regulation of transport|cellular localization|membrane-bounded organelle|negative regulation of cellular protein localization|intracellular|protein binding|endomembrane system|regulation of cellular localization|negative regulation of protein localization to nucleus|transport|intracellular membrane-bounded organelle|maintenance of location in cell|cytoplasm|regulation of protein localization|establishment of protein localization|negative regulation of intracellular transport|protein localization|establishment of localization in cell|negative regulation of intracellular protein transport|negative regulation of protein transport|Golgi apparatus|cytosol|negative regulation of protein import into nucleus|establishment of protein localization to organelle|regulation of intracellular transport|regulation of protein transport|protein transport|regulation of establishment of protein localization|intracellular transport|ion transport|maintenance of protein location in cell|perinuclear region of cytoplasm|cellular protein localization|protein import|regulation of cellular protein localization|protein import into nucleus|cytoplasmic sequestering of protein|regulation of protein import|anion transport|organic anion transport|protein localization to organelle|regulation of intracellular protein transport|nuclear transport|cation transport|protein targeting|carboxylic acid transport|cytosolic transport|intracellular protein transport|negative regulation of transcription factor import into nucleus|amino acid transport|regulation of protein import into nucleus|regulation of protein localization to nucleus|transcription factor import into nucleus|regulation of protein targeting|neutral amino acid transport|nucleocytoplasmic transport|regulation of transcription factor import into nucleus|cytoplasmic sequestering of transcription factor|protein localization to nucleus|regulation of nucleocytoplasmic transport|D-serine transport|nuclear import K05872 NF-kappa-B inhibitor epsilon[-] hsa05169|hsa04722|hsa04660|hsa04662|hsa04920 Epstein-Barr virus infection - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human) 6:44258166-44265788 336 383 467 191 196 170 4.58480007459775 4.74962714524334 5.74528986813218 2.3351323455878 2.19433879087071 2.17399441535882 5.02657236265776 2.23448851727244 1.16963032554425 5.17790884544265e-08 8.40572543076916e-07 UP ENSG00000115211 EIF2B4 eukaryotic translation initiation factor 2B subunit delta [Source:HGNC Symbol;Acc:HGNC:3260] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0009628|GO:0042698|GO:0044237|GO:0003006|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0022602|GO:0005515|GO:0043234|GO:0005085|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0048468|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0033554|GO:0048608|GO:0001541|GO:0006413|GO:0010243|GO:0005737|GO:0009408|GO:0007548|GO:0009890|GO:0043085|GO:0008406|GO:0009725|GO:0005851|GO:0050790|GO:0048869|GO:0044249|GO:0009266|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0031369|GO:0032268|GO:0005829|GO:0009743|GO:0010468|GO:0034645|GO:0043555|GO:0006518|GO:0003723|GO:0008585|GO:0061458|GO:0007417|GO:0021782|GO:0051345|GO:0010629|GO:0006446|GO:1901652|GO:0046545|GO:0032269|GO:0043434|GO:0045947|GO:0043603|GO:0044267|GO:0010467|GO:0007399|GO:0051246|GO:0009059|GO:0030154|GO:0008366|GO:0043043|GO:0010001|GO:0017148|GO:0014003|GO:0034284|GO:0043087|GO:0010608|GO:0006412|GO:0043547|GO:0006417|GO:0043558|GO:0048709|GO:0008135|GO:0032055|GO:0042552|GO:0032057|GO:0022008|GO:0003743|GO:0042063|GO:0009749 developmental process|macromolecular complex|reproduction|cell|rhythmic process|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|ovulation cycle|cellular metabolic process|developmental process involved in reproduction|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|ovulation cycle process|protein binding|protein complex|guanyl-nucleotide exchange factor activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|cell development|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|cellular response to stress|reproductive structure development|ovarian follicle development|translational initiation|response to organonitrogen compound|cytoplasm|response to heat|sex differentiation|negative regulation of biosynthetic process|positive regulation of catalytic activity|gonad development|response to hormone|eukaryotic translation initiation factor 2B complex|regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|translation initiation factor binding|regulation of cellular protein metabolic process|cytosol|response to carbohydrate|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of translation in response to stress|peptide metabolic process|RNA binding|female gonad development|reproductive system development|central nervous system development|glial cell development|positive regulation of hydrolase activity|negative regulation of gene expression|regulation of translational initiation|response to peptide|development of primary female sexual characteristics|negative regulation of cellular protein metabolic process|response to peptide hormone|negative regulation of translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|nervous system development|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|axon ensheathment|peptide biosynthetic process|glial cell differentiation|negative regulation of translation|oligodendrocyte development|response to monosaccharide|regulation of GTPase activity|posttranscriptional regulation of gene expression|translation|positive regulation of GTPase activity|regulation of translation|regulation of translational initiation in response to stress|oligodendrocyte differentiation|translation factor activity, RNA binding|negative regulation of translation in response to stress|myelination|negative regulation of translational initiation in response to stress|neurogenesis|translation initiation factor activity|gliogenesis|response to glucose K03680 translation initiation factor eIF-2B subunit delta[-] hsa03013 RNA transport - Homo sapiens (human) 2:27364352-27370486 973 1124 902 552 521 393 6.44085442678141 6.76202968702092 5.38333655598478 3.2739169484518 2.82967099643811 2.4381004776307 6.19540688992904 2.84722947417354 1.12164026336546 5.30033337794203e-08 8.59979090571095e-07 UP ENSG00000182871 COL18A1 collagen, type XVIII, alpha 1 [Source:HGNC Symbol;Acc:HGNC:2195] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0005604|GO:1903561|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0005578|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0005615|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0042802|GO:0048514|GO:0008284|GO:0051272|GO:0042127|GO:0009888|GO:0048468|GO:0001568|GO:0010941|GO:0007275|GO:0048513|GO:0050877|GO:0043062|GO:0031982|GO:0051599|GO:2000147|GO:0010942|GO:0043231|GO:0043169|GO:0005737|GO:0006928|GO:0009887|GO:0042493|GO:0044236|GO:0001525|GO:0051270|GO:0016477|GO:0005783|GO:0070062|GO:0008219|GO:0008285|GO:0048869|GO:2000145|GO:0010035|GO:0005581|GO:0000902|GO:0030574|GO:0044259|GO:0046872|GO:0001944|GO:0022617|GO:0072358|GO:0002064|GO:0000904|GO:0030334|GO:0007600|GO:0012501|GO:0060429|GO:0005788|GO:0030198|GO:0030154|GO:0030335|GO:0043068|GO:0072359|GO:0043067|GO:0003158|GO:0050953|GO:0001885|GO:0043065|GO:0030855|GO:0003382|GO:0042981|GO:0006915|GO:0032963|GO:0001886|GO:0045446|GO:1904037|GO:0007601|GO:0072577|GO:2000353|GO:2000351 locomotion|developmental process|extracellular matrix|macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|basement membrane|extracellular vesicle|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|proteinaceous extracellular matrix|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|extracellular space|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|identical protein binding|blood vessel morphogenesis|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|tissue development|cell development|blood vessel development|regulation of cell death|multicellular organism development|animal organ development|neurological system process|extracellular structure organization|vesicle|response to hydrostatic pressure|positive regulation of cell motility|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|cytoplasm|movement of cell or subcellular component|organ morphogenesis|response to drug|multicellular organism metabolic process|angiogenesis|regulation of cellular component movement|cell migration|endoplasmic reticulum|extracellular exosome|cell death|negative regulation of cell proliferation|cellular developmental process|regulation of cell motility|response to inorganic substance|collagen trimer|cell morphogenesis|collagen catabolic process|multicellular organismal macromolecule metabolic process|metal ion binding|vasculature development|extracellular matrix disassembly|cardiovascular system development|epithelial cell development|cell morphogenesis involved in differentiation|regulation of cell migration|sensory perception|programmed cell death|epithelium development|endoplasmic reticulum lumen|extracellular matrix organization|cell differentiation|positive regulation of cell migration|positive regulation of programmed cell death|circulatory system development|regulation of programmed cell death|endothelium development|sensory perception of light stimulus|endothelial cell development|positive regulation of apoptotic process|epithelial cell differentiation|epithelial cell morphogenesis|regulation of apoptotic process|apoptotic process|collagen metabolic process|endothelial cell morphogenesis|endothelial cell differentiation|positive regulation of epithelial cell apoptotic process|visual perception|endothelial cell apoptotic process|positive regulation of endothelial cell apoptotic process|regulation of endothelial cell apoptotic process K06823 collagen, type XVIII, alpha[-] hsa04974 Protein digestion and absorption - Homo sapiens (human) 21:45405137-45513720 669 747 1104 1760 2121 2368 4.14568316724577 4.20698256040635 6.1681267804486 9.77192445146898 10.783961863525 13.7524651550196 4.84026416936691 11.4361171566712 -1.24043961136218 5.33433135558204e-08 8.65025140084444e-07 DOWN ENSG00000138101 DTNB dystrobrevin beta [Source:HGNC Symbol;Acc:HGNC:3058] GO:0045202|GO:0005623|GO:0005488|GO:0043167|GO:0005622|GO:0005515|GO:0043169|GO:0005737|GO:0046872|GO:0046914|GO:0008270 synapse|cell|binding|ion binding|intracellular|protein binding|cation binding|cytoplasm|metal ion binding|transition metal ion binding|zinc ion binding - - - - 2:25377198-25673647 72 83 140 275 297 356 0.415795703817738 0.435617315472335 0.728935181196725 1.42290189761328 1.40724459628453 1.92674398383415 0.526782733495599 1.58563015924399 -1.58977634460093 5.37632528027197e-08 8.71361644501843e-07 DOWN ENSG00000119638 NEK9 NIMA-related kinase 9 [Source:HGNC Symbol;Acc:HGNC:18591] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0007049|GO:0022402|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0061024|GO:0007059|GO:0000166|GO:0051301|GO:0007017|GO:0019538|GO:0010256|GO:0006996|GO:0005829|GO:0005813|GO:0006998|GO:0046872|GO:0035639|GO:1903047|GO:0043412|GO:0005815|GO:0001883|GO:0036211|GO:0000278|GO:0032549|GO:0016301|GO:0019900|GO:0006796|GO:0044267|GO:0007067|GO:0017076|GO:0006997|GO:0016773|GO:0005856|GO:0005634|GO:0007077|GO:0005524|GO:0030554|GO:0016310|GO:0015630|GO:0051081|GO:0004672|GO:0019901|GO:0006464|GO:0006468|GO:0004674 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|transferase activity|cell cycle|cell cycle process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|membrane organization|chromosome segregation|nucleotide binding|cell division|microtubule-based process|protein metabolic process|endomembrane system organization|organelle organization|cytosol|centrosome|nuclear envelope organization|metal ion binding|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|microtubule organizing center|purine nucleoside binding|protein modification process|mitotic cell cycle|ribonucleoside binding|kinase activity|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|mitotic nuclear division|purine nucleotide binding|nucleus organization|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|mitotic nuclear envelope disassembly|ATP binding|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|nuclear envelope disassembly|protein kinase activity|protein kinase binding|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 14:75079353-75127344 1316 1584 2471 4110 4419 4892 5.65688355623867 6.1880899484612 9.57653509115971 15.8292732145746 15.5852383036908 19.7077390953317 7.14050286528653 17.0407502045324 -1.25489126657582 5.41392114455118e-08 8.76978848884596e-07 DOWN ENSG00000062194 GPBP1 GC-rich promoter binding protein 1 [Source:HGNC Symbol;Acc:HGNC:29520] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 5:57173948-57264679 652 727 815 1759 1665 1628 4.59503869608133 4.65646706042215 5.17861353353292 11.1072201673824 9.62773167275209 10.7528875850356 4.81003976334547 10.4959464750567 -1.12571154240398 5.43836845931747e-08 8.80461236358264e-07 DOWN ENSG00000069998 CECR5 cat eye syndrome chromosome region, candidate 5 [Source:HGNC Symbol;Acc:HGNC:1843] GO:0005623|GO:0009987|GO:0008152|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0044255|GO:0019637|GO:0043231|GO:0005737|GO:0006629|GO:0044249|GO:0008654|GO:0046486|GO:0005739|GO:0006796|GO:0008610|GO:0006644|GO:0046474|GO:0006650 cell|cellular process|metabolic process|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|cellular lipid metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|cellular biosynthetic process|phospholipid biosynthetic process|glycerolipid metabolic process|mitochondrion|phosphate-containing compound metabolic process|lipid biosynthetic process|phospholipid metabolic process|glycerophospholipid biosynthetic process|glycerophospholipid metabolic process - - - - 22:17137511-17165287 1136 1205 954 557 607 385 8.33579233633338 8.03592222813821 6.31147921622147 3.66202787500872 3.65447628114952 2.64763332201136 7.56106459356435 3.32137915938987 1.18680695309585 5.48415221647259e-08 8.87392304989553e-07 UP ENSG00000157869 RAB28 RAB28, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9768] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0071944|GO:0016787|GO:0005622|GO:0005886|GO:0005929|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0035253|GO:0005737|GO:0045184|GO:0036064|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0000166|GO:1901998|GO:0035639|GO:0005815|GO:0001883|GO:0015031|GO:0016818|GO:0046907|GO:0032549|GO:0034613|GO:0035556|GO:0017076|GO:0019003|GO:0005856|GO:0032561|GO:0051169|GO:0006886|GO:0015630|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0006913|GO:0017111|GO:0003924 signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|cellular localization|cell periphery|hydrolase activity|intracellular|plasma membrane|cilium|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|ciliary rootlet|cytoplasm|establishment of protein localization|ciliary basal body|protein localization|cell communication|signal transduction|establishment of localization in cell|nucleotide binding|toxin transport|purine ribonucleoside triphosphate binding|microtubule organizing center|purine nucleoside binding|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|cellular protein localization|intracellular signal transduction|purine nucleotide binding|GDP binding|cytoskeleton|guanyl ribonucleotide binding|nuclear transport|intracellular protein transport|microtubule cytoskeleton|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|nucleocytoplasmic transport|nucleoside-triphosphatase activity|GTPase activity - - - - 4:13361354-13484365 65 80 117 287 266 238 1.28218446875401 1.43418409546167 2.08083246311521 5.07241929033662 4.30511282273018 4.39988339902626 1.5990670091103 4.59247183736435 -1.52204047784796 5.49866634574794e-08 8.89258857453732e-07 DOWN ENSG00000112697 TMEM30A transmembrane protein 30A [Source:HGNC Symbol;Acc:HGNC:16667] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0050794|GO:0043229|GO:0051050|GO:0051641|GO:0045177|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0060341|GO:0045595|GO:0097035|GO:0048468|GO:0006810|GO:0051130|GO:0016324|GO:0007275|GO:0031982|GO:0051128|GO:0045597|GO:0043231|GO:0030133|GO:0005737|GO:0032880|GO:0012506|GO:0051222|GO:0045184|GO:0030658|GO:0042493|GO:0032388|GO:0008104|GO:0055085|GO:0061024|GO:0005783|GO:0051649|GO:0090316|GO:0030030|GO:0048869|GO:0016021|GO:0010876|GO:0005794|GO:0031175|GO:0031344|GO:0006855|GO:0031410|GO:0010720|GO:0070863|GO:0032386|GO:0051223|GO:0015031|GO:0031346|GO:0016023|GO:0070201|GO:0046907|GO:0006811|GO:0050769|GO:0006869|GO:0015893|GO:0031988|GO:0034613|GO:0030659|GO:0007399|GO:0030154|GO:1903827|GO:0051960|GO:0048666|GO:0030182|GO:0015914|GO:0045332|GO:0006820|GO:0010975|GO:0015711|GO:0033365|GO:0033157|GO:0032527|GO:0016482|GO:0006886|GO:0022008|GO:0050767|GO:0010976|GO:0045666|GO:0048699|GO:0070861|GO:0036010|GO:0045664 developmental process|cell|membrane|cellular process|response to stimulus|binding|regulation of cellular process|intracellular organelle|positive regulation of transport|cellular localization|apical part of cell|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of cellular localization|regulation of cell differentiation|regulation of membrane lipid distribution|cell development|transport|positive regulation of cellular component organization|apical plasma membrane|multicellular organism development|vesicle|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|regulation of protein localization|vesicle membrane|positive regulation of protein transport|establishment of protein localization|transport vesicle membrane|response to drug|positive regulation of intracellular transport|protein localization|transmembrane transport|membrane organization|endoplasmic reticulum|establishment of localization in cell|positive regulation of intracellular protein transport|cell projection organization|cellular developmental process|integral component of membrane|lipid localization|Golgi apparatus|neuron projection development|regulation of cell projection organization|drug transmembrane transport|cytoplasmic vesicle|positive regulation of cell development|positive regulation of protein exit from endoplasmic reticulum|regulation of intracellular transport|regulation of protein transport|protein transport|positive regulation of cell projection organization|cytoplasmic, membrane-bounded vesicle|regulation of establishment of protein localization|intracellular transport|ion transport|positive regulation of neurogenesis|lipid transport|drug transport|membrane-bounded vesicle|cellular protein localization|cytoplasmic vesicle membrane|nervous system development|cell differentiation|regulation of cellular protein localization|regulation of nervous system development|neuron development|neuron differentiation|phospholipid transport|phospholipid translocation|anion transport|regulation of neuron projection development|organic anion transport|protein localization to organelle|regulation of intracellular protein transport|protein exit from endoplasmic reticulum|cytosolic transport|intracellular protein transport|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|positive regulation of neuron differentiation|generation of neurons|regulation of protein exit from endoplasmic reticulum|protein localization to endosome|regulation of neuron differentiation - - - - 6:75252924-75284968 1164 1449 1991 3583 3707 3558 8.1530557883652 9.22392839250035 12.5734030579212 22.4859820540597 21.3038426319041 23.3562034943153 9.98346241292892 22.3820093934264 -1.16472740769385 5.57813940330835e-08 9.01623030570479e-07 DOWN ENSG00000078902 TOLLIP toll interacting protein [Source:HGNC Symbol;Acc:HGNC:16476] GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0045321|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0051641|GO:0006914|GO:0043227|GO:0071944|GO:0009893|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0032182|GO:0045087|GO:0009888|GO:0098797|GO:0005102|GO:0006952|GO:0031982|GO:0031325|GO:0005887|GO:0043231|GO:0019899|GO:0005737|GO:0007267|GO:0043235|GO:0001775|GO:0031226|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0048869|GO:0016021|GO:0019538|GO:0031323|GO:0032268|GO:0005829|GO:0035325|GO:0005126|GO:0070851|GO:0043412|GO:0032183|GO:0036211|GO:0006954|GO:0031981|GO:0051247|GO:0048471|GO:0005654|GO:0034613|GO:0019900|GO:0032270|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0044390|GO:0051246|GO:0030154|GO:0045323|GO:0045092|GO:0005634|GO:0044389|GO:0031625|GO:0033365|GO:0031401|GO:0030855|GO:0016310|GO:0016604|GO:0005149|GO:0031624|GO:0006464|GO:0018193|GO:0005150|GO:0036010|GO:0032446|GO:0033235|GO:0033233|GO:0018205|GO:0016925 developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|leukocyte activation|intracellular organelle|response to stress|organic substance metabolic process|immune response|cellular metabolic process|cellular localization|autophagy|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|ubiquitin-like protein binding|innate immune response|tissue development|plasma membrane protein complex|receptor binding|defense response|vesicle|positive regulation of cellular metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|cell-cell signaling|receptor complex|cell activation|intrinsic component of plasma membrane|protein localization|cell communication|signal transduction|extracellular exosome|cellular developmental process|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|Toll-like receptor binding|cytokine receptor binding|growth factor receptor binding|macromolecule modification|SUMO binding|protein modification process|inflammatory response|nuclear lumen|positive regulation of protein metabolic process|perinuclear region of cytoplasm|nucleoplasm|cellular protein localization|kinase binding|positive regulation of cellular protein metabolic process|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein metabolic process|cell differentiation|interleukin-1 receptor complex|interleukin-18 receptor complex|nucleus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|protein localization to organelle|positive regulation of protein modification process|epithelial cell differentiation|phosphorylation|nuclear body|interleukin-1 receptor binding|ubiquitin conjugating enzyme binding|cellular protein modification process|peptidyl-amino acid modification|interleukin-1, Type I receptor binding|protein localization to endosome|protein modification by small protein conjugation|positive regulation of protein sumoylation|regulation of protein sumoylation|peptidyl-lysine modification|protein sumoylation K05402 toll-interacting protein[-] hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) 11:1274371-1309654 1428 1250 1345 683 762 631 6.4163267749064 5.10444319999164 5.44872285242517 2.74964617104091 2.80918868674824 2.65715070652797 5.65649760910774 2.73866185477237 1.04643789531401 5.59362067780467e-08 9.03636102354874e-07 UP ENSG00000011198 ABHD5 abhydrolase domain containing 5 [Source:HGNC Symbol;Acc:HGNC:21396] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0010888|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0044255|GO:0010883|GO:0006082|GO:0016788|GO:0044281|GO:0019637|GO:0031325|GO:0043231|GO:0008233|GO:0016746|GO:0005737|GO:0043085|GO:0006629|GO:0019915|GO:0050790|GO:0010891|GO:0048869|GO:0044249|GO:0010876|GO:0019538|GO:0031323|GO:0090207|GO:0005829|GO:0008654|GO:0046486|GO:0051345|GO:0016042|GO:0050996|GO:0044242|GO:0006631|GO:0005811|GO:0050994|GO:0006638|GO:0006508|GO:0016747|GO:0006796|GO:0030730|GO:0008610|GO:0019216|GO:0030154|GO:0005634|GO:0052689|GO:0006644|GO:0071617|GO:0046474|GO:0046461|GO:0010898|GO:0019752|GO:0006639|GO:0060193|GO:0006650|GO:0008374|GO:0006654|GO:0061365|GO:0046473|GO:0046464|GO:0032787|GO:0006641|GO:0042171|GO:0051006|GO:0019433|GO:0003841 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|negative regulation of lipid storage|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular lipid metabolic process|regulation of lipid storage|organic acid metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|peptidase activity|transferase activity, transferring acyl groups|cytoplasm|positive regulation of catalytic activity|lipid metabolic process|lipid storage|regulation of catalytic activity|negative regulation of sequestering of triglyceride|cellular developmental process|cellular biosynthetic process|lipid localization|protein metabolic process|regulation of cellular metabolic process|regulation of triglyceride metabolic process|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|positive regulation of hydrolase activity|lipid catabolic process|positive regulation of lipid catabolic process|cellular lipid catabolic process|fatty acid metabolic process|lipid particle|regulation of lipid catabolic process|neutral lipid metabolic process|proteolysis|transferase activity, transferring acyl groups other than amino-acyl groups|phosphate-containing compound metabolic process|sequestering of triglyceride|lipid biosynthetic process|regulation of lipid metabolic process|cell differentiation|nucleus|carboxylic ester hydrolase activity|phospholipid metabolic process|lysophospholipid acyltransferase activity|glycerophospholipid biosynthetic process|neutral lipid catabolic process|positive regulation of triglyceride catabolic process|carboxylic acid metabolic process|acylglycerol metabolic process|positive regulation of lipase activity|glycerophospholipid metabolic process|O-acyltransferase activity|phosphatidic acid biosynthetic process|positive regulation of triglyceride lipase activity|phosphatidic acid metabolic process|acylglycerol catabolic process|monocarboxylic acid metabolic process|triglyceride metabolic process|lysophosphatidic acid acyltransferase activity|positive regulation of lipoprotein lipase activity|triglyceride catabolic process|1-acylglycerol-3-phosphate O-acyltransferase activity K13699 abhydrolase domain-containing protein 5[2.3.1.51] hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human) 3:43690113-43734371 66 88 107 310 298 208 0.953946452273311 1.15596293072295 1.39437774678463 4.01459401838952 3.53400128473101 2.81757212041794 1.16809570992696 3.45538914117949 -1.56468970534163 5.60755708979797e-08 9.05397562784362e-07 DOWN ENSG00000179348 GATA2 GATA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4171] GO:0040011|GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0002683|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0003006|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0002262|GO:0023057|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0042127|GO:1903706|GO:0048565|GO:0050817|GO:0001890|GO:0045648|GO:0045595|GO:0006725|GO:0051640|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:0051130|GO:1901360|GO:0048839|GO:0001568|GO:0007275|GO:0060627|GO:0016570|GO:0003676|GO:0045596|GO:0048513|GO:0034101|GO:0034641|GO:0032940|GO:0030902|GO:0030900|GO:0021517|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0045807|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0045646|GO:0005737|GO:0000981|GO:0009611|GO:0060322|GO:0007423|GO:0006928|GO:0009887|GO:0005667|GO:0042592|GO:0051656|GO:0001775|GO:0009966|GO:0048598|GO:0002263|GO:0048568|GO:0009890|GO:0019725|GO:0003682|GO:0048871|GO:0019904|GO:0010646|GO:0006139|GO:0001892|GO:0001525|GO:0007154|GO:0061024|GO:0016477|GO:0007165|GO:0002366|GO:0009968|GO:0051649|GO:0008134|GO:0061351|GO:0008285|GO:0043299|GO:0048869|GO:0044249|GO:0019827|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0021536|GO:0048732|GO:0050878|GO:0002443|GO:0006996|GO:0016192|GO:0051276|GO:0000982|GO:0032268|GO:0006909|GO:0005829|GO:0003677|GO:0070345|GO:0010468|GO:0034645|GO:0030218|GO:0055123|GO:0046872|GO:0007166|GO:0033993|GO:0001944|GO:0043412|GO:0061458|GO:0030097|GO:0072358|GO:0007417|GO:0001085|GO:0001655|GO:0010629|GO:0043583|GO:0010720|GO:0031056|GO:0048878|GO:0001894|GO:0007596|GO:2000178|GO:0051252|GO:0043303|GO:0006325|GO:0021510|GO:0001709|GO:0010725|GO:0005773|GO:0009790|GO:0016573|GO:0010628|GO:0006887|GO:0036211|GO:0045599|GO:0042060|GO:0070742|GO:0046907|GO:0001764|GO:0048872|GO:0055082|GO:0045576|GO:0021983|GO:0042472|GO:0045766|GO:0021533|GO:0035270|GO:0031981|GO:0050769|GO:0045765|GO:0007599|GO:0010324|GO:0035162|GO:0030100|GO:0021514|GO:0008593|GO:0005654|GO:0050766|GO:0060872|GO:0035019|GO:0021872|GO:1901342|GO:0033043|GO:0044267|GO:0010467|GO:0048562|GO:0045639|GO:0007399|GO:0046903|GO:1901534|GO:0045598|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0032418|GO:0001228|GO:0048469|GO:2000177|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0045638|GO:0030222|GO:0051960|GO:0045165|GO:0045637|GO:0045746|GO:0045995|GO:1901532|GO:0048666|GO:0030182|GO:0002521|GO:0002761|GO:0045654|GO:0021953|GO:0000975|GO:0045893|GO:0045444|GO:0045055|GO:0009792|GO:0050764|GO:0000323|GO:0045892|GO:0035854|GO:0032774|GO:0043565|GO:2001141|GO:0048873|GO:0001077|GO:0033044|GO:0021515|GO:1902679|GO:0060100|GO:0060319|GO:0003690|GO:0048663|GO:0002762|GO:0042471|GO:0021954|GO:0002448|GO:0060215|GO:0035065|GO:0046914|GO:0050801|GO:0006911|GO:0016568|GO:0002244|GO:0021879|GO:0030099|GO:0060216|GO:0006897|GO:0007219|GO:0022008|GO:0006464|GO:0045652|GO:0050767|GO:0006351|GO:0006355|GO:0006873|GO:0045666|GO:0045650|GO:0045944|GO:0006366|GO:0002573|GO:1903507|GO:0021877|GO:0006357|GO:0005764|GO:0048699|GO:1903506|GO:0044212|GO:0030219|GO:0018193|GO:2000977|GO:0043009|GO:0000122|GO:0097154|GO:0008270|GO:0045664|GO:0030003|GO:0035326|GO:0030225|GO:0001047|GO:0000976|GO:0055065|GO:0001012|GO:0030851|GO:0006875|GO:0021902|GO:0001701|GO:0006473|GO:0018205|GO:0042629|GO:0018394|GO:0001046|GO:0006874|GO:0000977|GO:0001158|GO:0055074|GO:0006475|GO:0018393|GO:0051480|GO:0000980|GO:0000979|GO:0007204 locomotion|developmental process|macromolecular complex|reproduction|immune system process|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|developmental process involved in reproduction|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|myeloid cell homeostasis|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|regulation of cell proliferation|regulation of hemopoiesis|digestive tract development|coagulation|placenta development|positive regulation of erythrocyte differentiation|regulation of cell differentiation|cellular aromatic compound metabolic process|organelle localization|tissue development|cell development|transport|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|inner ear development|blood vessel development|multicellular organism development|regulation of vesicle-mediated transport|histone modification|nucleic acid binding|negative regulation of cell differentiation|animal organ development|erythrocyte homeostasis|cellular nitrogen compound metabolic process|secretion by cell|hindbrain development|forebrain development|ventral spinal cord development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|positive regulation of endocytosis|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|regulation of erythrocyte differentiation|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|response to wounding|head development|sensory organ development|movement of cell or subcellular component|organ morphogenesis|transcription factor complex|homeostatic process|establishment of organelle localization|cell activation|regulation of signal transduction|embryonic morphogenesis|cell activation involved in immune response|embryonic organ development|negative regulation of biosynthetic process|cellular homeostasis|chromatin binding|multicellular organismal homeostasis|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|angiogenesis|cell communication|membrane organization|cell migration|signal transduction|leukocyte activation involved in immune response|negative regulation of signal transduction|establishment of localization in cell|transcription factor binding|neural precursor cell proliferation|negative regulation of cell proliferation|leukocyte degranulation|cellular developmental process|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|diencephalon development|gland development|regulation of body fluid levels|leukocyte mediated immunity|organelle organization|vesicle-mediated transport|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of cellular protein metabolic process|phagocytosis|cytosol|DNA binding|negative regulation of fat cell proliferation|regulation of gene expression|cellular macromolecule biosynthetic process|erythrocyte differentiation|digestive system development|metal ion binding|cell surface receptor signaling pathway|response to lipid|vasculature development|macromolecule modification|reproductive system development|hemopoiesis|cardiovascular system development|central nervous system development|RNA polymerase II transcription factor binding|urogenital system development|negative regulation of gene expression|ear development|positive regulation of cell development|regulation of histone modification|chemical homeostasis|tissue homeostasis|blood coagulation|negative regulation of neural precursor cell proliferation|regulation of RNA metabolic process|mast cell degranulation|chromatin organization|spinal cord development|cell fate determination|regulation of primitive erythrocyte differentiation|vacuole|embryo development|histone acetylation|positive regulation of gene expression|exocytosis|protein modification process|negative regulation of fat cell differentiation|wound healing|C2H2 zinc finger domain binding|intracellular transport|neuron migration|homeostasis of number of cells|cellular chemical homeostasis|mast cell activation|pituitary gland development|inner ear morphogenesis|positive regulation of angiogenesis|cell differentiation in hindbrain|endocrine system development|nuclear lumen|positive regulation of neurogenesis|regulation of angiogenesis|hemostasis|membrane invagination|embryonic hemopoiesis|regulation of endocytosis|ventral spinal cord interneuron differentiation|regulation of Notch signaling pathway|nucleoplasm|positive regulation of phagocytosis|semicircular canal development|somatic stem cell population maintenance|forebrain generation of neurons|regulation of vasculature development|regulation of organelle organization|cellular protein metabolic process|gene expression|embryonic organ morphogenesis|positive regulation of myeloid cell differentiation|nervous system development|secretion|positive regulation of hematopoietic progenitor cell differentiation|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|lysosome localization|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|cell maturation|regulation of neural precursor cell proliferation|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|negative regulation of myeloid cell differentiation|eosinophil differentiation|regulation of nervous system development|cell fate commitment|regulation of myeloid cell differentiation|negative regulation of Notch signaling pathway|regulation of embryonic development|regulation of hematopoietic progenitor cell differentiation|neuron development|neuron differentiation|leukocyte differentiation|regulation of myeloid leukocyte differentiation|positive regulation of megakaryocyte differentiation|central nervous system neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|fat cell differentiation|regulated exocytosis|embryo development ending in birth or egg hatching|regulation of phagocytosis|lytic vacuole|negative regulation of transcription, DNA-templated|eosinophil fate commitment|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|homeostasis of number of cells within a tissue|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of chromosome organization|cell differentiation in spinal cord|negative regulation of RNA biosynthetic process|positive regulation of phagocytosis, engulfment|primitive erythrocyte differentiation|double-stranded DNA binding|neuron fate commitment|negative regulation of myeloid leukocyte differentiation|ear morphogenesis|central nervous system neuron development|mast cell mediated immunity|primitive hemopoiesis|regulation of histone acetylation|transition metal ion binding|ion homeostasis|phagocytosis, engulfment|chromatin modification|hematopoietic progenitor cell differentiation|forebrain neuron differentiation|myeloid cell differentiation|definitive hemopoiesis|endocytosis|Notch signaling pathway|neurogenesis|cellular protein modification process|regulation of megakaryocyte differentiation|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular ion homeostasis|positive regulation of neuron differentiation|negative regulation of macrophage differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|myeloid leukocyte differentiation|negative regulation of nucleic acid-templated transcription|forebrain neuron fate commitment|regulation of transcription from RNA polymerase II promoter|lysosome|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|megakaryocyte differentiation|peptidyl-amino acid modification|regulation of forebrain neuron differentiation|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|GABAergic neuron differentiation|zinc ion binding|regulation of neuron differentiation|cellular cation homeostasis|enhancer binding|macrophage differentiation|core promoter binding|transcription regulatory region sequence-specific DNA binding|metal ion homeostasis|RNA polymerase II regulatory region DNA binding|granulocyte differentiation|cellular metal ion homeostasis|commitment of neuronal cell to specific neuron type in forebrain|in utero embryonic development|protein acetylation|peptidyl-lysine modification|mast cell granule|peptidyl-lysine acetylation|core promoter sequence-specific DNA binding|cellular calcium ion homeostasis|RNA polymerase II regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding|calcium ion homeostasis|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|regulation of cytosolic calcium ion concentration|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding|positive regulation of cytosolic calcium ion concentration - - - - 3:128479427-128493185 1539 1924 2161 860 943 1094 15.7477249153503 17.8922250467347 19.9364674277409 7.88451812725713 7.91696343454774 10.4912052804897 17.8588057966086 8.76422894743152 1.02693653450522 5.62689737612165e-08 9.08029158198571e-07 UP ENSG00000197969 VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:1908] GO:0032502|GO:0007610|GO:0005623|GO:0016020|GO:0005488|GO:0019898|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0007626|GO:0048856|GO:0006810|GO:0007275|GO:0031982|GO:0030141|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0035176|GO:0051649|GO:0016192|GO:0031410|GO:0015031|GO:0016023|GO:0046907|GO:0031988|GO:0031045|GO:0007399|GO:0048193|GO:0016482|GO:0016197|GO:0006892|GO:0006895 developmental process|behavior|cell|membrane|binding|extrinsic component of membrane|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|locomotory behavior|anatomical structure development|transport|multicellular organism development|vesicle|secretory granule|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|social behavior|establishment of localization in cell|vesicle-mediated transport|cytoplasmic vesicle|protein transport|cytoplasmic, membrane-bounded vesicle|intracellular transport|membrane-bounded vesicle|dense core granule|nervous system development|Golgi vesicle transport|cytosolic transport|endosomal transport|post-Golgi vesicle-mediated transport|Golgi to endosome transport - - - - 9:77177353-77421541 463 603 956 1574 1708 2241 1.26072563385752 1.49223472085368 2.34699421619711 3.84010038710184 3.81589096163135 5.71887914120882 1.69998485696944 4.458290163314 -1.39096862074194 5.66758152944629e-08 9.14100372663909e-07 DOWN ENSG00000102760 RGCC regulator of cell cycle [Source:HGNC Symbol;Acc:HGNC:20369] GO:0040011|GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044089|GO:0071704|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0009893|GO:0009058|GO:0030234|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0060341|GO:0001818|GO:0051726|GO:0042127|GO:0007049|GO:0016337|GO:0006959|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0010718|GO:0006810|GO:0022402|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0010632|GO:0048513|GO:0051302|GO:0034641|GO:0008047|GO:0043062|GO:0032940|GO:0030155|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0010942|GO:0001817|GO:0098609|GO:0045786|GO:0045597|GO:0043231|GO:0046332|GO:0019899|GO:1901201|GO:0005737|GO:0032970|GO:0001816|GO:0032880|GO:0051222|GO:0006928|GO:0001775|GO:1901203|GO:0050673|GO:0051782|GO:0045184|GO:0006956|GO:0045787|GO:0001819|GO:0032231|GO:0044236|GO:0006139|GO:0043085|GO:0007162|GO:0050776|GO:0001525|GO:0008104|GO:0051270|GO:0016477|GO:0032233|GO:0050778|GO:0008219|GO:0051271|GO:0008285|GO:0001666|GO:0051047|GO:0050790|GO:0051048|GO:1903531|GO:0051781|GO:0051301|GO:0019207|GO:0048869|GO:0030029|GO:2000145|GO:0044249|GO:0010633|GO:0019538|GO:0051224|GO:0031323|GO:2000146|GO:0006996|GO:0051090|GO:0051017|GO:0016525|GO:0032268|GO:0000902|GO:0005813|GO:0044259|GO:0010468|GO:0090132|GO:0034645|GO:0090068|GO:0044331|GO:0010712|GO:0032956|GO:2000736|GO:1903047|GO:0001944|GO:0043412|GO:0007010|GO:0072358|GO:0032964|GO:0010720|GO:0019887|GO:1903053|GO:0051252|GO:0005815|GO:0050709|GO:0050710|GO:0010717|GO:0044770|GO:0051223|GO:0015031|GO:0007050|GO:0000904|GO:0010628|GO:0030334|GO:0001935|GO:0001667|GO:0051347|GO:0036211|GO:0000278|GO:0071456|GO:0070201|GO:0050714|GO:0045737|GO:0051091|GO:0050715|GO:0022408|GO:0022407|GO:0051046|GO:0060485|GO:0045765|GO:0007346|GO:0010564|GO:0009306|GO:0051247|GO:0045930|GO:0022604|GO:0006259|GO:0050678|GO:0085029|GO:0050680|GO:0030036|GO:0071453|GO:0030336|GO:0050663|GO:0019900|GO:0032270|GO:0012501|GO:0070278|GO:0051054|GO:0006796|GO:1901342|GO:0033043|GO:0044267|GO:0051174|GO:0007067|GO:0048864|GO:0010467|GO:0019209|GO:0046903|GO:0010594|GO:0030198|GO:0031328|GO:0051246|GO:0010770|GO:0009059|GO:0030154|GO:0070412|GO:0051496|GO:0043068|GO:0050707|GO:0010714|GO:0016070|GO:0045931|GO:0072359|GO:0005856|GO:0010557|GO:0010596|GO:0090272|GO:0005634|GO:0051492|GO:0043067|GO:0072537|GO:0003331|GO:2000738|GO:0010948|GO:0010638|GO:0045893|GO:0048863|GO:1904031|GO:0031401|GO:0043065|GO:0071156|GO:0071850|GO:0010769|GO:0031659|GO:0007088|GO:0032774|GO:0044772|GO:2001141|GO:0014031|GO:0050708|GO:0043537|GO:0043535|GO:0016310|GO:0032967|GO:0001936|GO:1901990|GO:2000278|GO:0051493|GO:0045839|GO:0015630|GO:0030295|GO:0001937|GO:0010631|GO:0042981|GO:0045840|GO:0048762|GO:1901987|GO:2000573|GO:0031032|GO:0019901|GO:0030038|GO:0006464|GO:2000048|GO:0007015|GO:0051495|GO:0001837|GO:0071897|GO:0010458|GO:0000079|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0032963|GO:1901991|GO:0071158|GO:0033674|GO:0036294|GO:0045944|GO:2000045|GO:0006366|GO:0045859|GO:0045860|GO:0006357|GO:0006468|GO:1903506|GO:1904037|GO:0042325|GO:0001932|GO:1902806|GO:0043149|GO:0000082|GO:0001100|GO:0001934|GO:0061572|GO:0043542|GO:0042327|GO:0007096|GO:0072577|GO:2000353|GO:0071902|GO:2000351|GO:0071900|GO:0032147|GO:0043534 locomotion|developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|negative regulation of cytokine production|regulation of cell cycle|regulation of cell proliferation|cell cycle|single organismal cell-cell adhesion|humoral immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|positive regulation of epithelial to mesenchymal transition|transport|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|regulation of epithelial cell migration|animal organ development|regulation of cell division|cellular nitrogen compound metabolic process|enzyme activator activity|extracellular structure organization|secretion by cell|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|positive regulation of cell death|regulation of cytokine production|cell-cell adhesion|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|SMAD binding|enzyme binding|regulation of extracellular matrix assembly|cytoplasm|regulation of actin filament-based process|cytokine production|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|cell activation|positive regulation of extracellular matrix assembly|epithelial cell proliferation|negative regulation of cell division|establishment of protein localization|complement activation|positive regulation of cell cycle|positive regulation of cytokine production|regulation of actin filament bundle assembly|multicellular organism metabolic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|negative regulation of cell adhesion|regulation of immune response|angiogenesis|protein localization|regulation of cellular component movement|cell migration|positive regulation of actin filament bundle assembly|positive regulation of immune response|cell death|negative regulation of cellular component movement|negative regulation of cell proliferation|response to hypoxia|positive regulation of secretion|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|positive regulation of cell division|cell division|kinase regulator activity|cellular developmental process|actin filament-based process|regulation of cell motility|cellular biosynthetic process|negative regulation of epithelial cell migration|protein metabolic process|negative regulation of protein transport|regulation of cellular metabolic process|negative regulation of cell motility|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|actin filament bundle assembly|negative regulation of angiogenesis|regulation of cellular protein metabolic process|cell morphogenesis|centrosome|multicellular organismal macromolecule metabolic process|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|cell-cell adhesion mediated by cadherin|regulation of collagen metabolic process|regulation of actin cytoskeleton organization|regulation of stem cell differentiation|mitotic cell cycle process|vasculature development|macromolecule modification|cytoskeleton organization|cardiovascular system development|collagen biosynthetic process|positive regulation of cell development|protein kinase regulator activity|regulation of extracellular matrix organization|regulation of RNA metabolic process|microtubule organizing center|negative regulation of protein secretion|negative regulation of cytokine secretion|regulation of epithelial to mesenchymal transition|cell cycle phase transition|regulation of protein transport|protein transport|cell cycle arrest|cell morphogenesis involved in differentiation|positive regulation of gene expression|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|mitotic cell cycle|cellular response to hypoxia|regulation of establishment of protein localization|positive regulation of protein secretion|positive regulation of cyclin-dependent protein serine/threonine kinase activity|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cytokine secretion|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of secretion|mesenchyme development|regulation of angiogenesis|regulation of mitotic cell cycle|regulation of cell cycle process|protein secretion|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|regulation of cell morphogenesis|DNA metabolic process|regulation of epithelial cell proliferation|extracellular matrix assembly|negative regulation of epithelial cell proliferation|actin cytoskeleton organization|cellular response to oxygen levels|negative regulation of cell migration|cytokine secretion|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|extracellular matrix constituent secretion|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|regulation of vasculature development|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|stem cell development|gene expression|kinase activator activity|secretion|regulation of endothelial cell migration|extracellular matrix organization|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|R-SMAD binding|positive regulation of stress fiber assembly|positive regulation of programmed cell death|regulation of cytokine secretion|positive regulation of collagen metabolic process|RNA metabolic process|positive regulation of mitotic cell cycle|circulatory system development|cytoskeleton|positive regulation of macromolecule biosynthetic process|negative regulation of endothelial cell migration|negative regulation of fibroblast growth factor production|nucleus|regulation of stress fiber assembly|regulation of programmed cell death|fibroblast activation|positive regulation of extracellular matrix constituent secretion|positive regulation of stem cell differentiation|negative regulation of cell cycle process|positive regulation of organelle organization|positive regulation of transcription, DNA-templated|stem cell differentiation|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein modification process|positive regulation of apoptotic process|regulation of cell cycle arrest|mitotic cell cycle arrest|regulation of cell morphogenesis involved in differentiation|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|regulation of mitotic nuclear division|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|mesenchymal cell development|regulation of protein secretion|negative regulation of blood vessel endothelial cell migration|regulation of blood vessel endothelial cell migration|phosphorylation|positive regulation of collagen biosynthetic process|regulation of endothelial cell proliferation|regulation of mitotic cell cycle phase transition|regulation of DNA biosynthetic process|regulation of cytoskeleton organization|negative regulation of mitotic nuclear division|microtubule cytoskeleton|protein kinase activator activity|negative regulation of endothelial cell proliferation|epithelial cell migration|regulation of apoptotic process|positive regulation of mitotic nuclear division|mesenchymal cell differentiation|regulation of cell cycle phase transition|positive regulation of DNA biosynthetic process|actomyosin structure organization|protein kinase binding|contractile actin filament bundle assembly|cellular protein modification process|negative regulation of cell-cell adhesion mediated by cadherin|actin filament organization|positive regulation of cytoskeleton organization|epithelial to mesenchymal transition|DNA biosynthetic process|exit from mitosis|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|collagen metabolic process|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|positive regulation of kinase activity|cellular response to decreased oxygen levels|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|positive regulation of epithelial cell apoptotic process|regulation of phosphorylation|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|stress fiber assembly|G1/S transition of mitotic cell cycle|negative regulation of exit from mitosis|positive regulation of protein phosphorylation|actin filament bundle organization|endothelial cell migration|positive regulation of phosphorylation|regulation of exit from mitosis|endothelial cell apoptotic process|positive regulation of endothelial cell apoptotic process|positive regulation of protein serine/threonine kinase activity|regulation of endothelial cell apoptotic process|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|blood vessel endothelial cell migration - - - - 13:41457559-41470882 173 232 288 99 84 95 11.1757713315965 13.620688659675 16.7740746452761 5.73011871628719 4.45225456486211 5.75152647957775 13.8568448788492 5.31129992024235 1.38346189836373 5.68550671105245e-08 9.15577718398513e-07 UP ENSG00000135365 PHF21A PHD finger protein 21A [Source:HGNC Symbol;Acc:HGNC:24156] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0050817|GO:0003712|GO:0006725|GO:0042393|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0009611|GO:0009890|GO:0003682|GO:0006139|GO:0044249|GO:1990391|GO:0031324|GO:0031323|GO:0050878|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0007596|GO:0051252|GO:0006325|GO:0042060|GO:0031981|GO:0007599|GO:0005654|GO:0010467|GO:0000118|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0046914|GO:0016568|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0008270|GO:0000976|GO:0001012|GO:0000977 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|coagulation|transcription cofactor activity|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|response to wounding|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|DNA repair complex|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|blood coagulation|regulation of RNA metabolic process|chromatin organization|wound healing|nuclear lumen|hemostasis|nucleoplasm|gene expression|histone deacetylase complex|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transition metal ion binding|chromatin modification|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 11:45929323-46121178 198 247 461 804 807 1063 0.743137267110185 0.842521039857167 1.55997847744559 2.70369153203002 2.48510629973702 3.73908642915661 1.04854559480431 2.97596142030788 -1.50496622705424 5.68441341438854e-08 9.15577718398513e-07 DOWN ENSG00000138193 PLCE1 phospholipase C epsilon 1 [Source:HGNC Symbol;Acc:HGNC:17175] GO:0032502|GO:0040007|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0016049|GO:0005057|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0040008|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0005085|GO:0048856|GO:0031090|GO:0019222|GO:0007507|GO:0044255|GO:0001822|GO:0032835|GO:0007275|GO:0048513|GO:0043647|GO:0016788|GO:0044281|GO:0019637|GO:0031325|GO:0051128|GO:0043231|GO:0019899|GO:0005737|GO:0003012|GO:0042592|GO:0009966|GO:0072006|GO:0019725|GO:0010646|GO:0043085|GO:0007154|GO:0006629|GO:0007165|GO:0050790|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0001558|GO:0031323|GO:0005794|GO:0006996|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0007186|GO:0006936|GO:0046486|GO:0007166|GO:0043412|GO:0007010|GO:0072358|GO:0051345|GO:0001655|GO:0008277|GO:0016042|GO:0048878|GO:0006066|GO:0090257|GO:0051347|GO:0036211|GO:0072001|GO:0055082|GO:0006638|GO:0051247|GO:0032270|GO:0016298|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0008610|GO:0000139|GO:0051246|GO:0051020|GO:1902531|GO:0072359|GO:0042578|GO:0006644|GO:0004620|GO:0007200|GO:0031401|GO:0006939|GO:0008081|GO:0006937|GO:0043408|GO:0043087|GO:0016310|GO:0043547|GO:0007167|GO:0031267|GO:0043410|GO:0050801|GO:0006639|GO:0051056|GO:0007264|GO:0006464|GO:0019932|GO:0007205|GO:0043549|GO:0006873|GO:0033674|GO:0007265|GO:0004629|GO:0046578|GO:0045859|GO:0045860|GO:0043406|GO:0006940|GO:0006651|GO:0017016|GO:0006468|GO:0043405|GO:0042325|GO:0001932|GO:0046339|GO:0001934|GO:0019722|GO:0048016|GO:0030003|GO:0042327|GO:0007169|GO:0004435|GO:0000187|GO:0055065|GO:0071902|GO:0006875|GO:0071900|GO:0032147|GO:0038127|GO:0007173|GO:0006874|GO:0055074|GO:0051480|GO:0007204 developmental process|growth|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|cell growth|receptor signaling protein activity|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|regulation of growth|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|plasma membrane|endomembrane system|guanyl-nucleotide exchange factor activity|anatomical structure development|organelle membrane|regulation of metabolic process|heart development|cellular lipid metabolic process|kidney development|glomerulus development|multicellular organism development|animal organ development|inositol phosphate metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|muscle system process|homeostatic process|regulation of signal transduction|nephron development|cellular homeostasis|regulation of cell communication|positive regulation of catalytic activity|cell communication|lipid metabolic process|signal transduction|regulation of catalytic activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cell growth|regulation of cellular metabolic process|Golgi apparatus|organelle organization|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|muscle contraction|glycerolipid metabolic process|cell surface receptor signaling pathway|macromolecule modification|cytoskeleton organization|cardiovascular system development|positive regulation of hydrolase activity|urogenital system development|regulation of G-protein coupled receptor protein signaling pathway|lipid catabolic process|chemical homeostasis|alcohol metabolic process|regulation of muscle system process|positive regulation of transferase activity|protein modification process|renal system development|cellular chemical homeostasis|neutral lipid metabolic process|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|lipase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|lipid biosynthetic process|Golgi membrane|regulation of protein metabolic process|GTPase binding|regulation of intracellular signal transduction|circulatory system development|phosphoric ester hydrolase activity|phospholipid metabolic process|phospholipase activity|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of protein modification process|smooth muscle contraction|phosphoric diester hydrolase activity|regulation of muscle contraction|regulation of MAPK cascade|regulation of GTPase activity|phosphorylation|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|small GTPase binding|positive regulation of MAPK cascade|ion homeostasis|acylglycerol metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|cellular protein modification process|second-messenger-mediated signaling|protein kinase C-activating G-protein coupled receptor signaling pathway|regulation of kinase activity|cellular ion homeostasis|positive regulation of kinase activity|Ras protein signal transduction|phospholipase C activity|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of smooth muscle contraction|diacylglycerol biosynthetic process|Ras GTPase binding|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|diacylglycerol metabolic process|positive regulation of protein phosphorylation|calcium-mediated signaling|inositol phosphate-mediated signaling|cellular cation homeostasis|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|phosphatidylinositol phospholipase C activity|activation of MAPK activity|metal ion homeostasis|positive regulation of protein serine/threonine kinase activity|cellular metal ion homeostasis|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K05860 phosphatidylinositol phospholipase C, epsilon[3.1.4.11] hsa01100|hsa04014|hsa04015|hsa05205|hsa04024|hsa04020|hsa04919|hsa04933|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 10:93993989-94332823 364 357 929 1548 1770 2352 1.53886024445447 1.3716589329958 3.54101372929919 5.86362811907445 6.13958679387209 9.31889055612029 2.15051096891649 7.10736848968894 -1.72463600949584 5.68594188353602e-08 9.15577718398513e-07 DOWN ENSG00000106591 MRPL32 mitochondrial ribosomal protein L32 [Source:HGNC Symbol;Acc:HGNC:14035] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0031090|GO:0019866|GO:0003676|GO:0034641|GO:0005761|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0031966|GO:0044249|GO:0019538|GO:0006996|GO:0005740|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0005840|GO:0005743|GO:0005759|GO:0005739|GO:0015934|GO:0070124|GO:0043603|GO:0044267|GO:0010467|GO:0005762|GO:0009059|GO:0032543|GO:0043241|GO:0043043|GO:0070125|GO:0006412|GO:0044822|GO:0070126|GO:0006414|GO:0043624|GO:0006415 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|organelle membrane|organelle inner membrane|nucleic acid binding|cellular nitrogen compound metabolic process|mitochondrial ribosome|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|cellular biosynthetic process|protein metabolic process|organelle organization|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|ribosome|mitochondrial inner membrane|mitochondrial matrix|mitochondrion|large ribosomal subunit|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|mitochondrial large ribosomal subunit|macromolecule biosynthetic process|mitochondrial translation|protein complex disassembly|peptide biosynthetic process|mitochondrial translational elongation|translation|poly(A) RNA binding|mitochondrial translational termination|translational elongation|cellular protein complex disassembly|translational termination K02911 large subunit ribosomal protein L32[-] hsa03010 Ribosome - Homo sapiens (human) 7:42932200-42948958 1387 1396 1113 650 691 431 22.0426849436316 20.1629286454757 15.9476828336586 9.25548047489948 9.01019323720634 6.41940072165064 19.384432140922 8.22835814458549 1.23622197796946 5.70384488689202e-08 9.17470825718073e-07 UP ENSG00000166002 SMCO4 single-pass membrane protein with coiled-coil domains 4 [Source:HGNC Symbol;Acc:HGNC:24810] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 11:93478472-93543508 8 15 20 51 69 83 0.179356102562701 0.305654502644663 0.404298269392796 1.02450944710951 1.26929288838425 1.74403234036596 0.296436291533387 1.34594489195324 -2.18282535472706 5.70182339686184e-08 9.17470825718073e-07 DOWN ENSG00000227440 ATP5G1P4 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:39507] - - - - - - 3:172828736-172829176 96 89 88 35 23 10 15.3985336684089 12.9741503621203 12.7263833991005 5.03000830821122 3.02692295000175 1.50323802840722 13.6996891432099 3.18672309554006 2.10399758833037 5.74662933312254e-08 9.23854992520412e-07 UP ENSG00000143842 SOX13 SRY-box 13 [Source:HGNC Symbol;Acc:HGNC:11192] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0007155|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:1903706|GO:0016337|GO:0045595|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0070489|GO:0034641|GO:0030155|GO:0046483|GO:0098609|GO:0043231|GO:0001775|GO:0006139|GO:0046649|GO:0050865|GO:0048869|GO:0044249|GO:0031323|GO:0051249|GO:0003677|GO:0010468|GO:0034645|GO:0030097|GO:0030098|GO:0051252|GO:0034109|GO:0022407|GO:0031981|GO:0007159|GO:0005654|GO:0042110|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0002521|GO:0000975|GO:0050863|GO:0032774|GO:0043565|GO:2001141|GO:0030217|GO:0045619|GO:0070486|GO:0003690|GO:0046629|GO:0006351|GO:0006355|GO:0042492|GO:0045580|GO:1903506|GO:0044212|GO:0071593|GO:0000976|GO:0001012|GO:0045586|GO:0000977 developmental process|immune system process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cell adhesion|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|regulation of cell adhesion|heterocycle metabolic process|cell-cell adhesion|intracellular membrane-bounded organelle|cell activation|nucleobase-containing compound metabolic process|lymphocyte activation|regulation of cell activation|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of lymphocyte activation|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|hemopoiesis|lymphocyte differentiation|regulation of RNA metabolic process|homotypic cell-cell adhesion|regulation of cell-cell adhesion|nuclear lumen|leukocyte cell-cell adhesion|nucleoplasm|T cell activation|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|leukocyte differentiation|regulatory region DNA binding|regulation of T cell activation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|T cell differentiation|regulation of lymphocyte differentiation|leukocyte aggregation|double-stranded DNA binding|gamma-delta T cell activation|transcription, DNA-templated|regulation of transcription, DNA-templated|gamma-delta T cell differentiation|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|lymphocyte aggregation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|regulation of gamma-delta T cell differentiation|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 1:204073115-204127743 666 756 1200 1951 2357 2158 3.9076592182143 4.03129240387295 6.34801426222993 10.2564568424888 11.346713348192 11.866507987431 4.76232196143906 11.1565593927039 -1.22815511455711 5.74973425617794e-08 9.23856654918925e-07 DOWN ENSG00000040275 SPDL1 spindle apparatus coiled-coil protein 1 [Source:HGNC Symbol;Acc:HGNC:26010] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0050794|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0051640|GO:0022402|GO:0000776|GO:0043231|GO:0019899|GO:0005737|GO:0032403|GO:0051656|GO:0008104|GO:0007163|GO:0007154|GO:0007165|GO:0051649|GO:0007059|GO:0051301|GO:0007017|GO:0000940|GO:0006996|GO:0051276|GO:0005829|GO:0051653|GO:0000819|GO:0000075|GO:1903047|GO:0007080|GO:0007010|GO:0005815|GO:0000278|GO:0030010|GO:0043515|GO:0005694|GO:0034613|GO:0051293|GO:0035556|GO:0007067|GO:0000226|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0000777|GO:0051303|GO:0031577|GO:0033365|GO:0051294|GO:0000793|GO:0015630|GO:0040001|GO:0000070|GO:0000132|GO:0051310|GO:0007264|GO:0000775|GO:0034502|GO:0000779|GO:0071459|GO:0034501 macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|organelle localization|cell cycle process|kinetochore|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein complex binding|establishment of organelle localization|protein localization|establishment or maintenance of cell polarity|cell communication|signal transduction|establishment of localization in cell|chromosome segregation|cell division|microtubule-based process|condensed chromosome outer kinetochore|organelle organization|chromosome organization|cytosol|spindle localization|sister chromatid segregation|cell cycle checkpoint|mitotic cell cycle process|mitotic metaphase plate congression|cytoskeleton organization|microtubule organizing center|mitotic cell cycle|establishment of cell polarity|kinetochore binding|chromosome|cellular protein localization|establishment of spindle localization|intracellular signal transduction|mitotic nuclear division|microtubule cytoskeleton organization|cytoskeleton|spindle pole|nucleus|spindle|condensed chromosome kinetochore|establishment of chromosome localization|spindle checkpoint|protein localization to organelle|establishment of spindle orientation|condensed chromosome|microtubule cytoskeleton|establishment of mitotic spindle localization|mitotic sister chromatid segregation|establishment of mitotic spindle orientation|metaphase plate congression|small GTPase mediated signal transduction|chromosome, centromeric region|protein localization to chromosome|condensed chromosome, centromeric region|protein localization to chromosome, centromeric region|protein localization to kinetochore - - - - 5:169583634-169604778 252 264 282 756 803 532 2.07011023751867 1.97094968631684 2.08860102480514 5.56431559812634 5.41222410445989 4.09574487239825 2.04322031621355 5.02409485832816 -1.29801892827431 5.80765039939967e-08 9.32660543430219e-07 DOWN ENSG00000174028 FAM3C2 family with sequence similarity 3 member C2 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:34501] - - - - - - X:23075758-23076767 223 289 346 651 724 717 23.1635044616052 27.2820274970763 32.4032382609093 60.5867202723795 61.7028530252628 69.7986392945786 27.6162567398636 64.029404197407 -1.21321680356108 5.81666711908694e-08 9.33606345017321e-07 DOWN ENSG00000176170 SPHK1 sphingosine kinase 1 [Source:HGNC Symbol;Acc:HGNC:11240] GO:0040011|GO:0032502|GO:0040007|GO:0004871|GO:0000003|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0008021|GO:0097159|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0038023|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0006457|GO:0045927|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0007269|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0060341|GO:0008284|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:0044255|GO:0050804|GO:0045595|GO:0006725|GO:0048468|GO:0006810|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0006082|GO:0009991|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043168|GO:0030307|GO:0044281|GO:0032940|GO:0001956|GO:0006952|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0007420|GO:0050806|GO:0001817|GO:0045597|GO:0043231|GO:0043169|GO:0030133|GO:0019899|GO:0010243|GO:0004888|GO:0048144|GO:0005737|GO:0003012|GO:0001816|GO:0007267|GO:0031668|GO:0060322|GO:0032880|GO:0051222|GO:0006928|GO:0043005|GO:0009966|GO:0045184|GO:0045787|GO:0006979|GO:0060548|GO:0032388|GO:0010646|GO:0006139|GO:0001525|GO:1900182|GO:0008104|GO:0005516|GO:0007154|GO:0007565|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0006458|GO:0051649|GO:0009725|GO:0008219|GO:0001505|GO:0090316|GO:0051047|GO:0000166|GO:0030030|GO:0048869|GO:2000145|GO:0010035|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0001558|GO:0031323|GO:0042594|GO:0051090|GO:0046928|GO:0006836|GO:1902533|GO:0032268|GO:0042307|GO:0005829|GO:0031175|GO:0003677|GO:0007186|GO:0031344|GO:0010468|GO:0006936|GO:0034645|GO:0006665|GO:0046872|GO:0007166|GO:0014074|GO:0001959|GO:0033993|GO:0035639|GO:0030424|GO:0001944|GO:0043412|GO:0072594|GO:0072358|GO:0034097|GO:0007417|GO:0031410|GO:0042542|GO:0016042|GO:0010720|GO:0043069|GO:0051252|GO:0006066|GO:0044242|GO:0006631|GO:0046683|GO:0032386|GO:0001883|GO:0051223|GO:0015031|GO:0031346|GO:0006670|GO:0090257|GO:0006643|GO:0010628|GO:0010038|GO:0030334|GO:0016023|GO:0036211|GO:0000278|GO:0070201|GO:0070382|GO:0046907|GO:0042886|GO:0006954|GO:0032549|GO:0051091|GO:0019902|GO:0048145|GO:0045766|GO:0051046|GO:0050769|GO:0045765|GO:0007346|GO:0034599|GO:0051247|GO:0048146|GO:0070848|GO:0031988|GO:0033198|GO:0009267|GO:0016301|GO:1904591|GO:0034613|GO:0045987|GO:0032270|GO:0012501|GO:0014070|GO:0000302|GO:0006796|GO:1901342|GO:0035556|GO:0044267|GO:0014075|GO:0051174|GO:0051084|GO:0010467|GO:0017038|GO:0031503|GO:0008610|GO:0007399|GO:0046903|GO:0071310|GO:0017076|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0030335|GO:0031669|GO:1903827|GO:0030258|GO:1902531|GO:0016070|GO:0045931|GO:0072359|GO:0031667|GO:0016773|GO:0004930|GO:0010557|GO:0005634|GO:0043067|GO:0006690|GO:0048545|GO:0006606|GO:0051960|GO:0032652|GO:0048666|GO:0032026|GO:0030182|GO:1904589|GO:0033559|GO:0046512|GO:0045893|GO:0010975|GO:0019221|GO:0033365|GO:0033157|GO:0031401|GO:0070555|GO:0043122|GO:0032651|GO:0006939|GO:0010803|GO:0051169|GO:0006937|GO:0032570|GO:0000287|GO:0032774|GO:0005524|GO:0001676|GO:0045125|GO:2001141|GO:0071363|GO:0030554|GO:0008481|GO:0016310|GO:0015833|GO:0006605|GO:0051092|GO:0003376|GO:0032611|GO:0016482|GO:0019903|GO:0006886|GO:0019369|GO:0007167|GO:0043123|GO:0006633|GO:0007249|GO:0042993|GO:0042981|GO:0071345|GO:0043066|GO:0030149|GO:0019752|GO:0034612|GO:0042306|GO:0046834|GO:0042345|GO:1900180|GO:0034614|GO:0022008|GO:0017050|GO:0030148|GO:0046466|GO:0006464|GO:0019932|GO:0046456|GO:0050767|GO:0042991|GO:0010976|GO:0006351|GO:0070301|GO:0006915|GO:0006355|GO:0001727|GO:0046824|GO:0045666|GO:0006636|GO:1903533|GO:0006913|GO:0006940|GO:0042346|GO:0006468|GO:0048699|GO:0071356|GO:1903506|GO:0042325|GO:0046521|GO:0001932|GO:0019371|GO:0018193|GO:0033209|GO:0032787|GO:0001934|GO:0019722|GO:0042990|GO:0051721|GO:0038036|GO:0045664|GO:0042327|GO:0006693|GO:0046520|GO:0034504|GO:0046822|GO:0007268|GO:0007169|GO:0032446|GO:0048010|GO:0051170|GO:0031398|GO:0031396|GO:0001516|GO:0018107|GO:0010800|GO:0016567 locomotion|developmental process|growth|signal transducer activity|reproduction|synapse|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|synaptic vesicle|organic cyclic compound binding|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|signaling receptor activity|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|protein folding|positive regulation of growth|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|neurotransmitter secretion|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular lipid metabolic process|modulation of synaptic transmission|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|positive regulation of cell growth|small molecule metabolic process|secretion by cell|positive regulation of neurotransmitter secretion|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|brain development|positive regulation of synaptic transmission|regulation of cytokine production|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|transport vesicle|enzyme binding|response to organonitrogen compound|transmembrane signaling receptor activity|fibroblast proliferation|cytoplasm|muscle system process|cytokine production|cell-cell signaling|cellular response to extracellular stimulus|head development|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|neuron projection|regulation of signal transduction|establishment of protein localization|positive regulation of cell cycle|response to oxidative stress|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|positive regulation of protein localization to nucleus|protein localization|calmodulin binding|cell communication|female pregnancy|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|'de novo' protein folding|establishment of localization in cell|response to hormone|cell death|regulation of neurotransmitter levels|positive regulation of intracellular protein transport|positive regulation of secretion|nucleotide binding|cell projection organization|cellular developmental process|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|response to starvation|regulation of sequence-specific DNA binding transcription factor activity|regulation of neurotransmitter secretion|neurotransmitter transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|positive regulation of protein import into nucleus|cytosol|neuron projection development|DNA binding|G-protein coupled receptor signaling pathway|regulation of cell projection organization|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|sphingolipid metabolic process|metal ion binding|cell surface receptor signaling pathway|response to purine-containing compound|regulation of cytokine-mediated signaling pathway|response to lipid|purine ribonucleoside triphosphate binding|axon|vasculature development|macromolecule modification|establishment of protein localization to organelle|cardiovascular system development|response to cytokine|central nervous system development|cytoplasmic vesicle|response to hydrogen peroxide|lipid catabolic process|positive regulation of cell development|negative regulation of programmed cell death|regulation of RNA metabolic process|alcohol metabolic process|cellular lipid catabolic process|fatty acid metabolic process|response to organophosphorus|regulation of intracellular transport|purine nucleoside binding|regulation of protein transport|protein transport|positive regulation of cell projection organization|sphingosine metabolic process|regulation of muscle system process|membrane lipid metabolic process|positive regulation of gene expression|response to metal ion|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|protein modification process|mitotic cell cycle|regulation of establishment of protein localization|exocytic vesicle|intracellular transport|amide transport|inflammatory response|ribonucleoside binding|positive regulation of sequence-specific DNA binding transcription factor activity|phosphatase binding|regulation of fibroblast proliferation|positive regulation of angiogenesis|regulation of secretion|positive regulation of neurogenesis|regulation of angiogenesis|regulation of mitotic cell cycle|cellular response to oxidative stress|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|response to growth factor|membrane-bounded vesicle|response to ATP|cellular response to starvation|kinase activity|positive regulation of protein import|cellular protein localization|positive regulation of smooth muscle contraction|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|response to reactive oxygen species|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|response to amine|regulation of phosphorus metabolic process|'de novo' posttranslational protein folding|gene expression|protein import|protein complex localization|lipid biosynthetic process|nervous system development|secretion|cellular response to organic substance|purine nucleotide binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|positive regulation of cell migration|cellular response to nutrient levels|regulation of cellular protein localization|lipid modification|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of mitotic cell cycle|circulatory system development|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|G-protein coupled receptor activity|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|icosanoid metabolic process|response to steroid hormone|protein import into nucleus|regulation of nervous system development|regulation of interleukin-1 production|neuron development|response to magnesium ion|neuron differentiation|regulation of protein import|unsaturated fatty acid metabolic process|sphingosine biosynthetic process|positive regulation of transcription, DNA-templated|regulation of neuron projection development|cytokine-mediated signaling pathway|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|response to interleukin-1|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of interleukin-1 beta production|smooth muscle contraction|regulation of tumor necrosis factor-mediated signaling pathway|nuclear transport|regulation of muscle contraction|response to progesterone|magnesium ion binding|RNA biosynthetic process|ATP binding|long-chain fatty acid metabolic process|bioactive lipid receptor activity|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|sphinganine kinase activity|phosphorylation|peptide transport|protein targeting|positive regulation of NF-kappaB transcription factor activity|sphingosine-1-phosphate signaling pathway|interleukin-1 beta production|cytosolic transport|protein phosphatase binding|intracellular protein transport|arachidonic acid metabolic process|enzyme linked receptor protein signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|fatty acid biosynthetic process|I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription factor import into nucleus|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|sphingolipid catabolic process|carboxylic acid metabolic process|response to tumor necrosis factor|regulation of protein import into nucleus|lipid phosphorylation|regulation of NF-kappaB import into nucleus|regulation of protein localization to nucleus|cellular response to reactive oxygen species|neurogenesis|D-erythro-sphingosine kinase activity|sphingolipid biosynthetic process|membrane lipid catabolic process|cellular protein modification process|second-messenger-mediated signaling|icosanoid biosynthetic process|regulation of neurogenesis|transcription factor import into nucleus|positive regulation of neuron projection development|transcription, DNA-templated|cellular response to hydrogen peroxide|apoptotic process|regulation of transcription, DNA-templated|lipid kinase activity|positive regulation of nucleocytoplasmic transport|positive regulation of neuron differentiation|unsaturated fatty acid biosynthetic process|regulation of protein targeting|nucleocytoplasmic transport|regulation of smooth muscle contraction|positive regulation of NF-kappaB import into nucleus|protein phosphorylation|generation of neurons|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of phosphorylation|sphingoid catabolic process|regulation of protein phosphorylation|cyclooxygenase pathway|peptidyl-amino acid modification|tumor necrosis factor-mediated signaling pathway|monocarboxylic acid metabolic process|positive regulation of protein phosphorylation|calcium-mediated signaling|regulation of transcription factor import into nucleus|protein phosphatase 2A binding|sphingosine-1-phosphate receptor activity|regulation of neuron differentiation|positive regulation of phosphorylation|prostaglandin metabolic process|sphingoid biosynthetic process|protein localization to nucleus|regulation of nucleocytoplasmic transport|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|nuclear import|positive regulation of protein ubiquitination|regulation of protein ubiquitination|prostaglandin biosynthetic process|peptidyl-threonine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|protein ubiquitination K04718 sphingosine kinase[2.7.1.91] hsa01100|hsa04020|hsa05152|hsa04072|hsa04071|hsa04666|hsa04370|hsa00600 Metabolic pathways - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human) 17:76376584-76387860 996 1085 765 440 521 338 7.56592305443174 7.4905298571482 5.23936586479185 2.99469645337485 3.24719332774244 2.40629323536134 6.76527292545726 2.88272767215954 1.23071358316095 5.85122559712806e-08 9.38648516800974e-07 UP ENSG00000005884 ITGA3 integrin subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:6139] GO:0040011|GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0050840|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0060076|GO:0040012|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0050900|GO:0043167|GO:0009986|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0030427|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0097060|GO:0048646|GO:0048609|GO:0019222|GO:0007507|GO:0060341|GO:0051272|GO:0050817|GO:0003014|GO:0045595|GO:0009897|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0016323|GO:0035295|GO:0051130|GO:1901360|GO:0098797|GO:0007275|GO:0010632|GO:0030324|GO:0048513|GO:0050877|GO:0005102|GO:0034641|GO:0005924|GO:0043062|GO:0030155|GO:0005912|GO:0031982|GO:0046483|GO:0051128|GO:2000147|GO:0030426|GO:0090287|GO:0035640|GO:0005887|GO:0045597|GO:0043169|GO:0019899|GO:0005737|GO:0009611|GO:0032880|GO:0043235|GO:0071559|GO:0006928|GO:0032403|GO:0043005|GO:0031589|GO:0009966|GO:0048729|GO:0046983|GO:0048598|GO:0072006|GO:0045184|GO:0050839|GO:0001968|GO:0060135|GO:0030323|GO:0019904|GO:0042493|GO:0010646|GO:0006139|GO:0031226|GO:0008104|GO:0007154|GO:0001704|GO:0007565|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0090004|GO:0043236|GO:0009968|GO:0070062|GO:0045785|GO:0009725|GO:0007611|GO:0071437|GO:0010634|GO:0030030|GO:0031253|GO:0001948|GO:0048869|GO:0016021|GO:2000145|GO:0043954|GO:0044249|GO:0010033|GO:0031323|GO:0010256|GO:0050878|GO:0030111|GO:0031175|GO:0031344|GO:0010468|GO:0090132|GO:0071773|GO:0034645|GO:0034698|GO:0090150|GO:0046872|GO:0007166|GO:0097205|GO:0072358|GO:0001655|GO:0010720|GO:0007498|GO:0097061|GO:0046982|GO:0007596|GO:0051252|GO:0060541|GO:0005518|GO:0031346|GO:0009790|GO:0010628|GO:0030334|GO:0001667|GO:0007009|GO:0007613|GO:0071560|GO:0070201|GO:0007369|GO:0007160|GO:0042060|GO:0001764|GO:0005178|GO:0072001|GO:0031345|GO:0002020|GO:0001707|GO:0072657|GO:0050769|GO:0007599|GO:0097062|GO:0010810|GO:0048471|GO:0070848|GO:0030175|GO:0043588|GO:0034613|GO:0031527|GO:0008305|GO:1903078|GO:0035556|GO:0010467|GO:0071438|GO:0007399|GO:0071310|GO:0050890|GO:1902532|GO:0030198|GO:0030510|GO:0009059|GO:0010811|GO:0030154|GO:0030335|GO:1903827|GO:1902531|GO:0016070|GO:0072359|GO:0048332|GO:0051960|GO:0005925|GO:0048666|GO:0030182|GO:0016055|GO:0090003|GO:0010975|GO:0072659|GO:0090002|GO:0032774|GO:0048333|GO:2001141|GO:0071363|GO:0007229|GO:0007179|GO:0030509|GO:0007167|GO:0034667|GO:0010631|GO:1903076|GO:0051056|GO:0022008|GO:0007264|GO:0051058|GO:0050767|GO:1990778|GO:0010976|GO:0017015|GO:0006351|GO:0006355|GO:0045666|GO:0006366|GO:0007265|GO:0046578|GO:0006357|GO:0048699|GO:1903506|GO:0007178|GO:0045664|GO:0046580|GO:0035024|GO:0035023|GO:0007266 locomotion|developmental process|macromolecular complex|reproduction|immune system process|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|extracellular matrix binding|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|excitatory synapse|regulation of locomotion|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|leukocyte migration|ion binding|cell surface|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|anatomical structure development|synaptic membrane|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|heart development|regulation of cellular localization|positive regulation of cellular component movement|coagulation|renal system process|regulation of cell differentiation|external side of plasma membrane|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|basolateral plasma membrane|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|plasma membrane protein complex|multicellular organism development|regulation of epithelial cell migration|lung development|animal organ development|neurological system process|receptor binding|cellular nitrogen compound metabolic process|cell-substrate adherens junction|extracellular structure organization|regulation of cell adhesion|adherens junction|vesicle|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|growth cone|regulation of cellular response to growth factor stimulus|exploration behavior|integral component of plasma membrane|positive regulation of cell differentiation|cation binding|enzyme binding|cytoplasm|response to wounding|regulation of protein localization|receptor complex|response to transforming growth factor beta|movement of cell or subcellular component|protein complex binding|neuron projection|cell-substrate adhesion|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|nephron development|establishment of protein localization|cell adhesion molecule binding|fibronectin binding|maternal process involved in female pregnancy|respiratory tube development|protein domain specific binding|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|protein localization|cell communication|formation of primary germ layer|female pregnancy|membrane organization|regulation of cellular component movement|cell migration|signal transduction|positive regulation of establishment of protein localization to plasma membrane|laminin binding|negative regulation of signal transduction|extracellular exosome|positive regulation of cell adhesion|response to hormone|learning or memory|invadopodium|positive regulation of epithelial cell migration|cell projection organization|cell projection membrane|glycoprotein binding|cellular developmental process|integral component of membrane|regulation of cell motility|cellular component maintenance|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|regulation of body fluid levels|regulation of Wnt signaling pathway|neuron projection development|regulation of cell projection organization|regulation of gene expression|epithelium migration|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|response to gonadotropin|establishment of protein localization to membrane|metal ion binding|cell surface receptor signaling pathway|renal filtration|cardiovascular system development|urogenital system development|positive regulation of cell development|mesoderm development|dendritic spine organization|protein heterodimerization activity|blood coagulation|regulation of RNA metabolic process|respiratory system development|collagen binding|positive regulation of cell projection organization|embryo development|positive regulation of gene expression|regulation of cell migration|ameboidal-type cell migration|plasma membrane organization|memory|cellular response to transforming growth factor beta stimulus|regulation of establishment of protein localization|gastrulation|cell-matrix adhesion|wound healing|neuron migration|integrin binding|renal system development|negative regulation of cell projection organization|protease binding|mesoderm formation|protein localization to membrane|positive regulation of neurogenesis|hemostasis|dendritic spine maintenance|regulation of cell-substrate adhesion|perinuclear region of cytoplasm|response to growth factor|filopodium|skin development|cellular protein localization|filopodium membrane|integrin complex|positive regulation of protein localization to plasma membrane|intracellular signal transduction|gene expression|invadopodium membrane|nervous system development|cellular response to organic substance|cognition|negative regulation of intracellular signal transduction|extracellular matrix organization|regulation of BMP signaling pathway|macromolecule biosynthetic process|positive regulation of cell-substrate adhesion|cell differentiation|positive regulation of cell migration|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|mesoderm morphogenesis|regulation of nervous system development|focal adhesion|neuron development|neuron differentiation|Wnt signaling pathway|regulation of establishment of protein localization to plasma membrane|regulation of neuron projection development|protein localization to plasma membrane|establishment of protein localization to plasma membrane|RNA biosynthetic process|mesodermal cell differentiation|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|integrin-mediated signaling pathway|transforming growth factor beta receptor signaling pathway|BMP signaling pathway|enzyme linked receptor protein signaling pathway|integrin alpha3-beta1 complex|epithelial cell migration|regulation of protein localization to plasma membrane|regulation of small GTPase mediated signal transduction|neurogenesis|small GTPase mediated signal transduction|negative regulation of small GTPase mediated signal transduction|regulation of neurogenesis|protein localization to cell periphery|positive regulation of neuron projection development|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway|regulation of neuron differentiation|negative regulation of Ras protein signal transduction|negative regulation of Rho protein signal transduction|regulation of Rho protein signal transduction|Rho protein signal transduction K06482 integrin alpha 3[-] hsa05200|hsa04151|hsa04810|hsa04510|hsa05414|hsa04640|hsa05222|hsa05410|hsa04512|hsa05412 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 17:50055968-50090481 2382 2572 4703 7944 8346 8949 10.0744493712705 9.88622925827382 17.9336563442352 30.1034679690585 28.961824734481 35.471784817556 12.6314449912598 31.5123591736985 -1.31889807818587 5.94645593951561e-08 9.52859577840412e-07 DOWN ENSG00000157240 FZD1 frizzled class receptor 1 [Source:HGNC Symbol;Acc:HGNC:4038] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0009892|GO:0030055|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0009986|GO:0051051|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0009653|GO:0071944|GO:1903828|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0060341|GO:0060022|GO:1900181|GO:0003149|GO:0048286|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0007164|GO:0006810|GO:0035295|GO:1901360|GO:0009991|GO:0007275|GO:0030324|GO:0060411|GO:0048513|GO:0005102|GO:0034641|GO:0005924|GO:0005912|GO:0031325|GO:0046483|GO:0090287|GO:0061061|GO:0010243|GO:0004888|GO:0007267|GO:0031668|GO:0032880|GO:0009887|GO:0043005|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0045184|GO:0009890|GO:0030323|GO:0019904|GO:0042493|GO:0032387|GO:0010646|GO:0090288|GO:0006139|GO:0008104|GO:0007154|GO:0035148|GO:0007165|GO:0030278|GO:0003151|GO:0009968|GO:0003279|GO:0001503|GO:0051649|GO:0009725|GO:0017147|GO:0090317|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:0060021|GO:0051090|GO:0003205|GO:0007584|GO:0032268|GO:0030111|GO:0007186|GO:0010468|GO:0071773|GO:0034645|GO:0030178|GO:0042308|GO:0090101|GO:0007166|GO:0002009|GO:0033993|GO:0043412|GO:0072594|GO:0030514|GO:0072358|GO:0010629|GO:0051252|GO:0060541|GO:0032386|GO:0003007|GO:0051223|GO:0030165|GO:0045667|GO:0015031|GO:1901652|GO:0009790|GO:0001736|GO:0071417|GO:0010628|GO:0072175|GO:0036211|GO:0031670|GO:0035425|GO:0070201|GO:0060412|GO:0046907|GO:2000027|GO:0033273|GO:0001649|GO:0051091|GO:0016331|GO:0003231|GO:0043434|GO:0051247|GO:0070848|GO:0001664|GO:0001841|GO:0034613|GO:0032270|GO:0014070|GO:0060429|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0090177|GO:0017038|GO:0007399|GO:0060562|GO:0071310|GO:0060415|GO:0031328|GO:0030510|GO:0051246|GO:0030177|GO:0009059|GO:0030154|GO:0060606|GO:0003281|GO:0007517|GO:0031669|GO:1903827|GO:0016070|GO:0072359|GO:0031667|GO:0004930|GO:0032870|GO:0010557|GO:0097305|GO:0006606|GO:0051960|GO:0005925|GO:0045995|GO:0048644|GO:0042813|GO:0030182|GO:0016055|GO:1904589|GO:0045893|GO:0048863|GO:0033280|GO:0033365|GO:0033157|GO:0009792|GO:0031401|GO:0090090|GO:0051169|GO:0030855|GO:0001843|GO:1901653|GO:0060828|GO:0045892|GO:0035414|GO:0042249|GO:0032774|GO:2001141|GO:0001838|GO:0071363|GO:0016310|GO:0006605|GO:1902679|GO:0071407|GO:0090175|GO:0016482|GO:0006886|GO:0030509|GO:0007167|GO:0071375|GO:0071295|GO:0090178|GO:0003150|GO:0044339|GO:0005109|GO:0042306|GO:1900180|GO:0022008|GO:0006464|GO:0090263|GO:0071396|GO:0035411|GO:0006351|GO:0006355|GO:0001738|GO:1903533|GO:0006366|GO:0035567|GO:0006913|GO:1903507|GO:0006357|GO:0006468|GO:0048699|GO:0035412|GO:1903506|GO:0060070|GO:0042325|GO:0001932|GO:0090179|GO:0043009|GO:0001934|GO:0007178|GO:0060071|GO:0042327|GO:0034504|GO:0046822|GO:0071305|GO:0051170|GO:0044338 developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|negative regulation of metabolic process|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cell surface|negative regulation of transport|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|cell periphery|negative regulation of cellular protein localization|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|regulation of cellular localization|hard palate development|negative regulation of protein localization to nucleus|membranous septum morphogenesis|lung alveolus development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|establishment of tissue polarity|transport|tube development|organic cyclic compound metabolic process|response to extracellular stimulus|multicellular organism development|lung development|cardiac septum morphogenesis|animal organ development|receptor binding|cellular nitrogen compound metabolic process|cell-substrate adherens junction|adherens junction|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|muscle structure development|response to organonitrogen compound|transmembrane signaling receptor activity|cell-cell signaling|cellular response to extracellular stimulus|regulation of protein localization|organ morphogenesis|neuron projection|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|establishment of protein localization|negative regulation of biosynthetic process|respiratory tube development|protein domain specific binding|response to drug|negative regulation of intracellular transport|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|protein localization|cell communication|tube formation|signal transduction|regulation of ossification|outflow tract morphogenesis|negative regulation of signal transduction|cardiac septum development|ossification|establishment of localization in cell|response to hormone|Wnt-protein binding|negative regulation of intracellular protein transport|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|palate development|regulation of sequence-specific DNA binding transcription factor activity|cardiac chamber development|response to nutrient|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|G-protein coupled receptor signaling pathway|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|negative regulation of protein import into nucleus|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|morphogenesis of an epithelium|response to lipid|macromolecule modification|establishment of protein localization to organelle|negative regulation of BMP signaling pathway|cardiovascular system development|negative regulation of gene expression|regulation of RNA metabolic process|respiratory system development|regulation of intracellular transport|heart morphogenesis|regulation of protein transport|PDZ domain binding|regulation of osteoblast differentiation|protein transport|response to peptide|embryo development|establishment of planar polarity|cellular response to organonitrogen compound|positive regulation of gene expression|epithelial tube formation|protein modification process|cellular response to nutrient|autocrine signaling|regulation of establishment of protein localization|ventricular septum morphogenesis|intracellular transport|regulation of organ morphogenesis|response to vitamin|osteoblast differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|morphogenesis of embryonic epithelium|cardiac ventricle development|response to peptide hormone|positive regulation of protein metabolic process|response to growth factor|G-protein coupled receptor binding|neural tube formation|cellular protein localization|positive regulation of cellular protein metabolic process|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|establishment of planar polarity involved in neural tube closure|protein import|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|regulation of BMP signaling pathway|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|cell differentiation|tube closure|ventricular septum development|muscle organ development|cellular response to nutrient levels|regulation of cellular protein localization|RNA metabolic process|circulatory system development|response to nutrient levels|G-protein coupled receptor activity|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to alcohol|protein import into nucleus|regulation of nervous system development|focal adhesion|regulation of embryonic development|muscle organ morphogenesis|Wnt-activated receptor activity|neuron differentiation|Wnt signaling pathway|regulation of protein import|positive regulation of transcription, DNA-templated|stem cell differentiation|response to vitamin D|protein localization to organelle|regulation of intracellular protein transport|embryo development ending in birth or egg hatching|positive regulation of protein modification process|negative regulation of canonical Wnt signaling pathway|nuclear transport|epithelial cell differentiation|neural tube closure|cellular response to peptide|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|negative regulation of catenin import into nucleus|establishment of planar polarity of embryonic epithelium|RNA biosynthetic process|regulation of RNA biosynthetic process|embryonic epithelial tube formation|cellular response to growth factor stimulus|phosphorylation|protein targeting|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|regulation of establishment of planar polarity|cytosolic transport|intracellular protein transport|BMP signaling pathway|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|cellular response to vitamin|regulation of establishment of planar polarity involved in neural tube closure|muscular septum morphogenesis|canonical Wnt signaling pathway involved in osteoblast differentiation|frizzled binding|regulation of protein import into nucleus|regulation of protein localization to nucleus|neurogenesis|cellular protein modification process|positive regulation of canonical Wnt signaling pathway|cellular response to lipid|catenin import into nucleus|transcription, DNA-templated|regulation of transcription, DNA-templated|morphogenesis of a polarized epithelium|regulation of protein targeting|transcription from RNA polymerase II promoter|non-canonical Wnt signaling pathway|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|generation of neurons|regulation of catenin import into nucleus|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|regulation of phosphorylation|regulation of protein phosphorylation|planar cell polarity pathway involved in neural tube closure|chordate embryonic development|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|Wnt signaling pathway, planar cell polarity pathway|positive regulation of phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|cellular response to vitamin D|nuclear import|canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation K02432 frizzled 1/7[-] hsa05200|hsa05166|hsa05205|hsa04390|hsa04310|hsa04550|hsa04916|hsa05217 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human) 7:91264364-91271326 409 478 418 188 235 193 4.15501731943873 4.41324016129699 3.82860236264381 1.71121866735784 1.95878044321134 1.83753708791596 4.13228661445984 1.83584539949505 1.1704957512707 5.94938786458943e-08 9.52859577840412e-07 UP ENSG00000182263 FIGN fidgetin [Source:HGNC Symbol;Acc:HGNC:13285] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0019222|GO:0007049|GO:0006281|GO:0006725|GO:0008022|GO:0022402|GO:1901360|GO:0034641|GO:0043168|GO:0005874|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0005737|GO:0006139|GO:0000166|GO:0051301|GO:0031323|GO:0006996|GO:0000725|GO:0035639|GO:1903047|GO:0005815|GO:0001883|GO:0006302|GO:0016818|GO:0000278|GO:0032549|GO:0031981|GO:2001020|GO:0006259|GO:0016363|GO:0006282|GO:0007067|GO:0017076|GO:0034399|GO:0005856|GO:0005634|GO:0006974|GO:0000724|GO:0005524|GO:0030554|GO:2000779|GO:0015630|GO:0000018|GO:0006310|GO:0016462|GO:0010569|GO:0017111|GO:0016887|GO:0042623|GO:0008568 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|regulation of metabolic process|cell cycle|DNA repair|cellular aromatic compound metabolic process|protein C-terminus binding|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|microtubule|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nucleotide binding|cell division|regulation of cellular metabolic process|organelle organization|recombinational repair|purine ribonucleoside triphosphate binding|mitotic cell cycle process|microtubule organizing center|purine nucleoside binding|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|ribonucleoside binding|nuclear lumen|regulation of response to DNA damage stimulus|DNA metabolic process|nuclear matrix|regulation of DNA repair|mitotic nuclear division|purine nucleotide binding|nuclear periphery|cytoskeleton|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|ATP binding|adenyl nucleotide binding|regulation of double-strand break repair|microtubule cytoskeleton|regulation of DNA recombination|DNA recombination|pyrophosphatase activity|regulation of double-strand break repair via homologous recombination|nucleoside-triphosphatase activity|ATPase activity|ATPase activity, coupled|microtubule-severing ATPase activity - - - - 2:163593396-163736012 3 29 46 177 206 176 0.0198127165159582 0.174044266705646 0.273872632887891 1.04724218271504 1.11611763277834 1.08922442477939 0.155909872036498 1.08419474675759 -2.79783973591508 5.95930723989652e-08 9.5393650584381e-07 DOWN ENSG00000250461 RP11-631M6.2 - - - - - - - 5:61375112-61375855 224 223 196 67 101 86 21.2971061435845 19.2689499842612 16.8012963032085 5.70746885635459 7.87880194444427 7.66300977148894 19.1224508103514 7.08309352409593 1.43281594012515 5.980222345608e-08 9.56771478594754e-07 UP ENSG00000198130 HIBCH 3-hydroxyisobutyryl-CoA hydrolase [Source:HGNC Symbol;Acc:HGNC:4908] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0006082|GO:0034641|GO:0016788|GO:0044281|GO:0031982|GO:0043231|GO:0005737|GO:0006520|GO:0070062|GO:0009081|GO:0016790|GO:0016836|GO:0009063|GO:0005759|GO:0005739|GO:0009083|GO:0046395|GO:0006573|GO:0019752|GO:0006574|GO:0003860 cell|cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|organic acid metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|extracellular exosome|branched-chain amino acid metabolic process|thiolester hydrolase activity|hydro-lyase activity|cellular amino acid catabolic process|mitochondrial matrix|mitochondrion|branched-chain amino acid catabolic process|carboxylic acid catabolic process|valine metabolic process|carboxylic acid metabolic process|valine catabolic process|3-hydroxyisobutyryl-CoA hydrolase activity K05605 3-hydroxyisobutyryl-CoA hydrolase[3.1.2.4] hsa01100|hsa01200|hsa00280|hsa00640|hsa00410 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Valine, leucine and isoleucine degradation - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human)|beta-Alanine metabolism - Homo sapiens (human) 2:190189735-190344193 58 52 102 234 228 225 0.390774877020694 0.318405534632976 0.619598157786795 1.41257325119563 1.26037908344003 1.42072546549647 0.442926189813488 1.36455926671071 -1.62329684627025 6.06418511256814e-08 9.69684961706531e-07 DOWN ENSG00000180998 GPR137C G protein-coupled receptor 137C [Source:HGNC Symbol;Acc:HGNC:25445] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 14:52553148-52637713 19 14 27 76 82 76 0.156148579817542 0.104568633566512 0.200066693358243 0.559631979026758 0.55293951605719 0.585378331527848 0.153594635580766 0.565983275537265 -1.88163159329736 6.07057722324303e-08 9.70187432669686e-07 DOWN ENSG00000140534 TICRR TOPBP1-interacting checkpoint and replication regulator [Source:HGNC Symbol;Acc:HGNC:28704] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0009314|GO:0022402|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0022607|GO:0045786|GO:0043231|GO:0006413|GO:0003682|GO:0006139|GO:0044249|GO:0022613|GO:0019538|GO:0031323|GO:0000075|GO:0034645|GO:0006518|GO:1903047|GO:0001731|GO:0044770|GO:0000278|GO:0022618|GO:0031981|GO:0007346|GO:0010564|GO:0045930|GO:0005654|GO:0006259|GO:0043603|GO:0010212|GO:0044267|GO:0010467|GO:0009059|GO:0005634|GO:0006974|GO:0010948|GO:0006270|GO:0043043|GO:0006260|GO:0034622|GO:0033314|GO:0007093|GO:0000086|GO:0044772|GO:0044774|GO:1901990|GO:0006412|GO:0006275|GO:1901987|GO:1901991|GO:0010389|GO:0044818|GO:0010972|GO:0006261|GO:1902750|GO:0030174|GO:1902749|GO:0000076 cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|response to radiation|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|negative regulation of cell cycle|intracellular membrane-bounded organelle|translational initiation|chromatin binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|regulation of cellular metabolic process|cell cycle checkpoint|cellular macromolecule biosynthetic process|peptide metabolic process|mitotic cell cycle process|formation of translation preinitiation complex|cell cycle phase transition|mitotic cell cycle|ribonucleoprotein complex assembly|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|nucleoplasm|DNA metabolic process|cellular amide metabolic process|response to ionizing radiation|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|negative regulation of cell cycle process|DNA replication initiation|peptide biosynthetic process|DNA replication|cellular macromolecular complex assembly|mitotic DNA replication checkpoint|mitotic cell cycle checkpoint|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|mitotic DNA integrity checkpoint|regulation of mitotic cell cycle phase transition|translation|regulation of DNA replication|regulation of cell cycle phase transition|negative regulation of mitotic cell cycle phase transition|regulation of G2/M transition of mitotic cell cycle|mitotic G2/M transition checkpoint|negative regulation of G2/M transition of mitotic cell cycle|DNA-dependent DNA replication|negative regulation of cell cycle G2/M phase transition|regulation of DNA-dependent DNA replication initiation|regulation of cell cycle G2/M phase transition|DNA replication checkpoint - - - - 15:89575482-89631056 179 158 193 502 623 383 1.15464809281298 0.926262422806217 1.12245701876472 2.901340324551 3.29726027194862 2.31539428537608 1.06778917812797 2.83799829395857 -1.41024688942705 6.08807450780603e-08 9.72463222878765e-07 DOWN ENSG00000147316 MCPH1 microcephalin 1 [Source:HGNC Symbol;Acc:HGNC:6954] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009605|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0042802|GO:0051726|GO:0007049|GO:0051640|GO:0022402|GO:0007275|GO:0048513|GO:0006952|GO:0030900|GO:0051128|GO:0007420|GO:0045786|GO:0043231|GO:0005737|GO:0009611|GO:0032886|GO:0060322|GO:0021987|GO:0051656|GO:0008104|GO:0007163|GO:0051649|GO:0060348|GO:0021543|GO:0050790|GO:0021537|GO:0007017|GO:0019827|GO:0031323|GO:0006996|GO:0031023|GO:0051276|GO:0051653|GO:0010468|GO:1903047|GO:0007010|GO:0007417|GO:0050727|GO:0070507|GO:0005815|GO:0007098|GO:0097150|GO:0007050|GO:0000278|GO:0006954|GO:0031981|GO:0030010|GO:0010564|GO:0005654|GO:0034613|GO:0051293|GO:0006796|GO:0033043|GO:0051174|GO:0010467|GO:0007399|GO:0001501|GO:0000226|GO:0005856|GO:0005634|GO:0030261|GO:0033365|GO:0071850|GO:0051294|GO:0016310|GO:0033044|GO:0051493|GO:0015630|GO:0051297|GO:0040001|GO:0000132|GO:0046605|GO:0060623|GO:0071103|GO:0043549|GO:0006323|GO:0042325|GO:0044380|GO:0071539 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|response to external stimulus|intracellular|protein binding|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cell cycle|cell cycle|organelle localization|cell cycle process|multicellular organism development|animal organ development|defense response|forebrain development|regulation of cellular component organization|brain development|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|response to wounding|regulation of microtubule-based process|head development|cerebral cortex development|establishment of organelle localization|protein localization|establishment or maintenance of cell polarity|establishment of localization in cell|bone development|pallium development|regulation of catalytic activity|telencephalon development|microtubule-based process|stem cell population maintenance|regulation of cellular metabolic process|organelle organization|microtubule organizing center organization|chromosome organization|spindle localization|regulation of gene expression|mitotic cell cycle process|cytoskeleton organization|central nervous system development|regulation of inflammatory response|regulation of microtubule cytoskeleton organization|microtubule organizing center|centrosome cycle|neuronal stem cell population maintenance|cell cycle arrest|mitotic cell cycle|inflammatory response|nuclear lumen|establishment of cell polarity|regulation of cell cycle process|nucleoplasm|cellular protein localization|establishment of spindle localization|phosphate-containing compound metabolic process|regulation of organelle organization|regulation of phosphorus metabolic process|gene expression|nervous system development|skeletal system development|microtubule cytoskeleton organization|cytoskeleton|nucleus|chromosome condensation|protein localization to organelle|mitotic cell cycle arrest|establishment of spindle orientation|phosphorylation|regulation of chromosome organization|regulation of cytoskeleton organization|microtubule cytoskeleton|centrosome organization|establishment of mitotic spindle localization|establishment of mitotic spindle orientation|regulation of centrosome cycle|regulation of chromosome condensation|DNA conformation change|regulation of kinase activity|DNA packaging|regulation of phosphorylation|protein localization to cytoskeleton|protein localization to centrosome - - - - 8:6406592-6648504 91 122 123 306 341 282 0.472582952980916 0.575805803806363 0.575909755257153 1.42382348693715 1.45297825181492 1.37250622195725 0.541432837348144 1.41643598690311 -1.38741111006649 6.13489143634258e-08 9.79417374013751e-07 DOWN ENSG00000162408 NOL9 nucleolar protein 9 [Source:HGNC Symbol;Acc:HGNC:26265] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0043231|GO:0051186|GO:0006139|GO:0000166|GO:0044249|GO:0022613|GO:0019538|GO:0005730|GO:0003723|GO:0035639|GO:0001883|GO:0042254|GO:0006777|GO:0032549|GO:0031981|GO:0016301|GO:0006796|GO:0044267|GO:0010467|GO:0042273|GO:0017076|GO:0016070|GO:0043545|GO:0016773|GO:0005634|GO:0006364|GO:0032561|GO:0090501|GO:0006396|GO:0051731|GO:0005524|GO:0034660|GO:0030554|GO:0016310|GO:0019205|GO:0032324|GO:0009108|GO:0000470|GO:0016071|GO:0005525|GO:0090305|GO:0019001|GO:0000460|GO:0000469|GO:0006397|GO:0090502|GO:0016072|GO:0000463|GO:0031123|GO:0031124|GO:0000479|GO:0000466|GO:0000448 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|nucleolus|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribosome biogenesis|Mo-molybdopterin cofactor biosynthetic process|ribonucleoside binding|nuclear lumen|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|ribosomal large subunit biogenesis|purine nucleotide binding|RNA metabolic process|molybdopterin cofactor metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|rRNA processing|guanyl ribonucleotide binding|RNA phosphodiester bond hydrolysis|RNA processing|polynucleotide 5'-hydroxyl-kinase activity|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|phosphorylation|nucleobase-containing compound kinase activity|molybdopterin cofactor biosynthetic process|coenzyme biosynthetic process|maturation of LSU-rRNA|mRNA metabolic process|GTP binding|nucleic acid phosphodiester bond hydrolysis|guanyl nucleotide binding|maturation of 5.8S rRNA|cleavage involved in rRNA processing|mRNA processing|RNA phosphodiester bond hydrolysis, endonucleolytic|rRNA metabolic process|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA 3'-end processing|mRNA 3'-end processing|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) - - - - 1:6521347-6554535 843 969 590 376 367 249 6.75247915238165 7.05406941327052 4.26090470532838 2.69849020987581 2.41196029332192 1.86923288243839 6.02248442366018 2.32656112854537 1.37215966387413 6.28811931045316e-08 1.00334320627615e-06 UP ENSG00000214160 ALG3 ALG3, alpha-1,3- mannosyltransferase [Source:HGNC Symbol;Acc:HGNC:23056] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0044255|GO:0043231|GO:0005737|GO:0005975|GO:0006629|GO:0005783|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0006490|GO:0034645|GO:0043412|GO:0006487|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0009059|GO:0097502|GO:0009101|GO:0043413|GO:0000030|GO:0006488|GO:0018279|GO:0006464|GO:0000033|GO:0018193|GO:0043687|GO:0052925 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|protein glycosylation|cellular lipid metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|macromolecule modification|protein N-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|mannosylation|glycoprotein biosynthetic process|macromolecule glycosylation|mannosyltransferase activity|dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|cellular protein modification process|alpha-1,3-mannosyltransferase activity|peptidyl-amino acid modification|post-translational protein modification|dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity K03845 alpha-1,3-mannosyltransferase[2.4.1.258] hsa01100|hsa00510 Metabolic pathways - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 3:184242301-184249548 2048 2297 1892 1050 1167 1022 17.6111227248516 17.9513914233197 14.6687256510037 8.08991625331326 8.23371645422148 8.23639245110947 16.743746599725 8.1866750528814 1.03227284524249 6.306038897185e-08 1.00566498523804e-06 UP ENSG00000185480 PARPBP PARP1 binding protein [Source:HGNC Symbol;Acc:HGNC:26074] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0000785|GO:0043227|GO:0005622|GO:0005515|GO:0019222|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0006139|GO:0031324|GO:0031323|GO:0003677|GO:0051053|GO:0045738|GO:0000725|GO:0006302|GO:0031981|GO:2001020|GO:0005654|GO:0006259|GO:0005694|GO:0006282|GO:0005634|GO:0006974|GO:0000724|GO:0045910|GO:2000779|GO:0000018|GO:0006310|GO:2000780|GO:0010569|GO:2000042 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|chromatin|membrane-bounded organelle|intracellular|protein binding|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|negative regulation of DNA metabolic process|negative regulation of DNA repair|recombinational repair|double-strand break repair|nuclear lumen|regulation of response to DNA damage stimulus|nucleoplasm|DNA metabolic process|chromosome|regulation of DNA repair|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|negative regulation of DNA recombination|regulation of double-strand break repair|regulation of DNA recombination|DNA recombination|negative regulation of double-strand break repair|regulation of double-strand break repair via homologous recombination|negative regulation of double-strand break repair via homologous recombination - - - - 12:102120185-102197520 49 81 87 272 274 178 0.379348827496151 0.569913745546952 0.607258799696808 1.88672593248885 1.74044719699447 1.29148993422264 0.51884045757997 1.63955435456865 -1.65994084480306 6.34099767495046e-08 1.01070018466616e-06 DOWN ENSG00000139163 ETNK1 ethanolamine kinase 1 [Source:HGNC Symbol;Acc:HGNC:24649] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0044255|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0043231|GO:0005737|GO:0006629|GO:0000166|GO:0016021|GO:0044249|GO:0005829|GO:0008654|GO:0046486|GO:0035639|GO:0001883|GO:0032549|GO:0031981|GO:0005654|GO:0016301|GO:0006796|GO:0008610|GO:0017076|GO:0016773|GO:0005634|GO:0006644|GO:0004305|GO:0046474|GO:0005524|GO:0030554|GO:0016310|GO:0006650|GO:0006646|GO:0046337 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|transferase activity|cellular lipid metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|nucleotide binding|integral component of membrane|cellular biosynthetic process|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|nuclear lumen|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|lipid biosynthetic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|phospholipid metabolic process|ethanolamine kinase activity|glycerophospholipid biosynthetic process|ATP binding|adenyl nucleotide binding|phosphorylation|glycerophospholipid metabolic process|phosphatidylethanolamine biosynthetic process|phosphatidylethanolamine metabolic process K00894 ethanolamine kinase[2.7.1.82] hsa01100|hsa00564 Metabolic pathways - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human) 12:22625075-22690665 2211 2557 3204 1204 1505 1487 15.5869207945283 16.3825836544534 20.3647138458412 7.60494138032162 8.70514617889105 9.82452803714745 17.4447394316076 8.71153853212004 1.00179260975517 6.40408369849942e-08 1.02021085771079e-06 UP ENSG00000138231 DBR1 debranching RNA lariats 1 [Source:HGNC Symbol;Acc:HGNC:15594] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0046872|GO:0003723|GO:0004518|GO:0010467|GO:0016070|GO:0005634|GO:0090501|GO:0006396|GO:0016071|GO:0004519|GO:0004540|GO:0044822|GO:0090305|GO:0006397|GO:0090502|GO:0004521|GO:0008380|GO:0000375|GO:0016891|GO:0000398|GO:0008419 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|metal ion binding|RNA binding|nuclease activity|gene expression|RNA metabolic process|nucleus|RNA phosphodiester bond hydrolysis|RNA processing|mRNA metabolic process|endonuclease activity|ribonuclease activity|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|mRNA processing|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|RNA splicing|RNA splicing, via transesterification reactions|endoribonuclease activity, producing 5'-phosphomonoesters|mRNA splicing, via spliceosome|RNA lariat debranching enzyme activity - - - - 3:138161012-138174949 1150 1141 789 477 538 395 21.5775528552989 19.4567381820138 13.3473690802411 8.01901136901153 8.28236930701037 6.94593732399669 18.1272200391846 7.7491060000062 1.22605590864644 6.47454168087385e-08 1.03088515915098e-06 UP ENSG00000112367 FIG4 FIG4 phosphoinositide 5-phosphatase [Source:HGNC Symbol;Acc:HGNC:16873] GO:0032502|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0043473|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0007626|GO:0048856|GO:0048646|GO:0031090|GO:0044255|GO:0045595|GO:0048468|GO:0051130|GO:0031641|GO:0007275|GO:0050877|GO:0016788|GO:0044281|GO:0019637|GO:0051128|GO:0022607|GO:0045597|GO:0043231|GO:0005737|GO:0031645|GO:0006629|GO:0005783|GO:0031642|GO:0010008|GO:0030030|GO:0048869|GO:0016021|GO:0044249|GO:0005794|GO:0005768|GO:0006996|GO:0031175|GO:0031344|GO:0008654|GO:0046486|GO:0010720|GO:0005769|GO:0031346|GO:0055037|GO:0005770|GO:0050769|GO:0031644|GO:0031901|GO:0006796|GO:0032288|GO:0008610|GO:0007399|GO:0000139|GO:0030154|GO:0031902|GO:0042578|GO:0006644|GO:0051960|GO:0007033|GO:0008366|GO:0048666|GO:0030182|GO:0016311|GO:0010975|GO:0046474|GO:0016791|GO:0042552|GO:0022008|GO:0050767|GO:0010976|GO:0006650|GO:0045666|GO:0046488|GO:0048699|GO:0006661|GO:0052866|GO:0045664|GO:0036092|GO:0034595|GO:0034593|GO:0043813|GO:0004438|GO:0043812 developmental process|behavior|cell|membrane|cellular process|metabolic process|binding|catalytic activity|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|pigmentation|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|endomembrane system|locomotory behavior|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|cellular lipid metabolic process|regulation of cell differentiation|cell development|positive regulation of cellular component organization|regulation of myelination|multicellular organism development|neurological system process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|negative regulation of neurological system process|lipid metabolic process|endoplasmic reticulum|negative regulation of myelination|endosome membrane|cell projection organization|cellular developmental process|integral component of membrane|cellular biosynthetic process|Golgi apparatus|endosome|organelle organization|neuron projection development|regulation of cell projection organization|phospholipid biosynthetic process|glycerolipid metabolic process|positive regulation of cell development|early endosome|positive regulation of cell projection organization|recycling endosome|late endosome|positive regulation of neurogenesis|regulation of neurological system process|early endosome membrane|phosphate-containing compound metabolic process|myelin assembly|lipid biosynthetic process|nervous system development|Golgi membrane|cell differentiation|late endosome membrane|phosphoric ester hydrolase activity|phospholipid metabolic process|regulation of nervous system development|vacuole organization|axon ensheathment|neuron development|neuron differentiation|dephosphorylation|regulation of neuron projection development|glycerophospholipid biosynthetic process|phosphatase activity|myelination|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|glycerophospholipid metabolic process|positive regulation of neuron differentiation|phosphatidylinositol metabolic process|generation of neurons|phosphatidylinositol biosynthetic process|phosphatidylinositol phosphate phosphatase activity|regulation of neuron differentiation|phosphatidylinositol-3-phosphate biosynthetic process|phosphatidylinositol phosphate 5-phosphatase activity|phosphatidylinositol bisphosphate phosphatase activity|phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-4-phosphate phosphatase activity - - - - 6:109691312-109825428 101 123 191 395 387 394 1.80142569162471 1.99378935461004 3.07143408063047 6.31229732320653 5.66332899895929 6.58595510995709 2.28888304228841 6.18719381070764 -1.43464148063455 6.48899778509288e-08 1.03263614006483e-06 DOWN ENSG00000157456 CCNB2 cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] GO:0032502|GO:0040007|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0001776|GO:0016043|GO:0043227|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0051726|GO:0007049|GO:0022402|GO:0007275|GO:0048513|GO:0043231|GO:0005737|GO:0042592|GO:0061024|GO:0002260|GO:0051301|GO:0010256|GO:0048732|GO:0006996|GO:0005829|GO:0005813|GO:0006998|GO:0048538|GO:1903047|GO:0005815|GO:0044770|GO:0009790|GO:0000278|GO:0048872|GO:0043029|GO:0031981|GO:0005654|GO:0007067|GO:0006997|GO:0005856|GO:0005634|GO:0007077|GO:0009792|GO:0000086|GO:0044772|GO:0015630|GO:0051081|GO:0043009|GO:0001701 developmental process|growth|immune system process|cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|leukocyte homeostasis|cellular component organization|membrane-bounded organelle|intracellular|immune system development|protein binding|anatomical structure development|regulation of cell cycle|cell cycle|cell cycle process|multicellular organism development|animal organ development|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|membrane organization|lymphocyte homeostasis|cell division|endomembrane system organization|gland development|organelle organization|cytosol|centrosome|nuclear envelope organization|thymus development|mitotic cell cycle process|microtubule organizing center|cell cycle phase transition|embryo development|mitotic cell cycle|homeostasis of number of cells|T cell homeostasis|nuclear lumen|nucleoplasm|mitotic nuclear division|nucleus organization|cytoskeleton|nucleus|mitotic nuclear envelope disassembly|embryo development ending in birth or egg hatching|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|microtubule cytoskeleton|nuclear envelope disassembly|chordate embryonic development|in utero embryonic development K05868 cyclin B[-] hsa05166|hsa04068|hsa04110|hsa04114|hsa04914|hsa04115 HTLV-I infection - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 15:59105078-59125045 324 409 460 1084 1167 746 5.15723100143741 5.9166374831227 6.60152333181753 15.4596165549449 15.2408981891147 11.128571450453 5.89179727212588 13.9430287315042 -1.24276428486242 6.67899441607439e-08 1.06173961287266e-06 DOWN ENSG00000225339 RP11-513I15.6 - - - - - - - 6:34248568-34286768 35 19 28 102 199 97 0.211785636835682 0.104490091031667 0.152756091322005 0.553007237917964 0.987988353573813 0.550084943190169 0.156343939729785 0.697026844893982 -2.15649092230822 6.73968339923254e-08 1.07081696753959e-06 DOWN ENSG00000100335 MIEF1 mitochondrial elongation factor 1 [Source:HGNC Symbol;Acc:HGNC:25979] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0019867|GO:0031224|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0048856|GO:0031090|GO:0042802|GO:0060341|GO:0006810|GO:0051130|GO:0043168|GO:0001882|GO:0051128|GO:0043231|GO:0090141|GO:0005737|GO:0032880|GO:0051222|GO:0031966|GO:0045184|GO:0032388|GO:0008104|GO:0061024|GO:0051649|GO:0090316|GO:0000166|GO:0016021|GO:0006996|GO:0005740|GO:0090150|GO:0007005|GO:0005741|GO:0032386|GO:0001883|GO:0051223|GO:0015031|GO:0070201|GO:0046907|GO:0032549|GO:0043531|GO:0072657|GO:0005739|GO:0034613|GO:0033043|GO:0090140|GO:0017076|GO:0019003|GO:1903827|GO:0090314|GO:0010638|GO:0032561|GO:0000266|GO:0033157|GO:0030554|GO:0006605|GO:0010822|GO:0006886|GO:0010821|GO:0019001|GO:0006612|GO:1903533 developmental process|cell|membrane|cellular process|binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|outer membrane|intrinsic component of membrane|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|anatomical structure development|organelle membrane|identical protein binding|regulation of cellular localization|transport|positive regulation of cellular component organization|anion binding|nucleoside binding|regulation of cellular component organization|intracellular membrane-bounded organelle|positive regulation of mitochondrial fission|cytoplasm|regulation of protein localization|positive regulation of protein transport|mitochondrial membrane|establishment of protein localization|positive regulation of intracellular transport|protein localization|membrane organization|establishment of localization in cell|positive regulation of intracellular protein transport|nucleotide binding|integral component of membrane|organelle organization|mitochondrial envelope|establishment of protein localization to membrane|mitochondrion organization|mitochondrial outer membrane|regulation of intracellular transport|purine nucleoside binding|regulation of protein transport|protein transport|regulation of establishment of protein localization|intracellular transport|ribonucleoside binding|ADP binding|protein localization to membrane|mitochondrion|cellular protein localization|regulation of organelle organization|regulation of mitochondrial fission|purine nucleotide binding|GDP binding|regulation of cellular protein localization|positive regulation of protein targeting to membrane|positive regulation of organelle organization|guanyl ribonucleotide binding|mitochondrial fission|regulation of intracellular protein transport|adenyl nucleotide binding|protein targeting|positive regulation of mitochondrion organization|intracellular protein transport|regulation of mitochondrion organization|guanyl nucleotide binding|protein targeting to membrane|regulation of protein targeting - - - - 22:39499432-39518132 2895 2400 2838 1480 1352 1380 11.6149494175659 8.75104687979774 10.265863489417 5.3202041895369 4.45054727171552 5.18891854413059 10.2106199289269 4.986556668461 1.0339546103349 6.76260163274667e-08 1.07368434144042e-06 UP ENSG00000143110 C1orf162 chromosome 1 open reading frame 162 [Source:HGNC Symbol;Acc:HGNC:28344] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 1:111473792-111478512 49 55 40 17 5 7 0.841901927819367 0.85883702672011 0.619639380984892 0.261705716592219 0.0704881941277376 0.112720605876713 0.77345944517479 0.148304838865557 2.38275997820583 6.76492344827974e-08 1.07368434144042e-06 UP ENSG00000111962 UST uronyl-2-sulfotransferase [Source:HGNC Symbol;Acc:HGNC:17223] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0045595|GO:0048468|GO:0006082|GO:0007275|GO:0044281|GO:0051128|GO:0043231|GO:0005737|GO:0005975|GO:0007163|GO:0030030|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0000902|GO:0031175|GO:0031344|GO:0034645|GO:0043412|GO:0000904|GO:0030204|GO:0009100|GO:0036211|GO:0030010|GO:0022604|GO:1901137|GO:0044267|GO:0008146|GO:0032990|GO:0007399|GO:0000139|GO:0051923|GO:0030205|GO:0009059|GO:0030154|GO:0048858|GO:0051960|GO:0048666|GO:0030182|GO:0009101|GO:0010975|GO:0010769|GO:0030208|GO:0061564|GO:0006477|GO:0006024|GO:0006029|GO:0019752|GO:0030203|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0050655|GO:0007409|GO:0048699|GO:0032787|GO:0030166|GO:0050770|GO:0045664|GO:0050651 developmental process|cell|membrane|cellular process|metabolic process|catalytic activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of cell differentiation|cell development|organic acid metabolic process|multicellular organism development|small molecule metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|establishment or maintenance of cell polarity|cell projection organization|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|cell morphogenesis|neuron projection development|regulation of cell projection organization|cellular macromolecule biosynthetic process|macromolecule modification|cell morphogenesis involved in differentiation|chondroitin sulfate metabolic process|glycoprotein metabolic process|protein modification process|establishment of cell polarity|regulation of cell morphogenesis|carbohydrate derivative biosynthetic process|cellular protein metabolic process|sulfotransferase activity|cell part morphogenesis|nervous system development|Golgi membrane|sulfation|dermatan sulfate metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|regulation of nervous system development|neuron development|neuron differentiation|glycoprotein biosynthetic process|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|dermatan sulfate biosynthetic process|axon development|protein sulfation|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|carboxylic acid metabolic process|glycosaminoglycan metabolic process|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|dermatan sulfate proteoglycan metabolic process|axonogenesis|generation of neurons|monocarboxylic acid metabolic process|proteoglycan biosynthetic process|regulation of axonogenesis|regulation of neuron differentiation|dermatan sulfate proteoglycan biosynthetic process K03193 dermatan/chondrotin sulfate uronyl 2-O-sulfotransferase UST [EC:2.8.2.-][-] hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human) 6:148747328-149076990 28 22 84 198 201 256 0.394072030142761 0.281400844755179 1.06590188440439 2.49680859304993 2.32106092063224 3.3766944526876 0.580458253100777 2.73152132212326 -2.23444046822953 6.8799682659538e-08 1.09136329761841e-06 DOWN ENSG00000168389 MFSD2A major facilitator superfamily domain containing 2A [Source:HGNC Symbol;Acc:HGNC:25897] GO:0032502|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0042175|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0048468|GO:0006810|GO:0005887|GO:0043231|GO:0005737|GO:0005319|GO:0031226|GO:0055085|GO:0005783|GO:0048869|GO:0016021|GO:0010876|GO:0016192|GO:0045056|GO:0005548|GO:0060856|GO:0006811|GO:0006869|GO:0030154|GO:0015914|GO:0006820|GO:0015711|GO:0015293|GO:1990379|GO:0015908|GO:0046942|GO:0015718 developmental process|transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|cell development|transport|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|lipid transporter activity|intrinsic component of plasma membrane|transmembrane transport|endoplasmic reticulum|cellular developmental process|integral component of membrane|lipid localization|vesicle-mediated transport|transcytosis|phospholipid transporter activity|establishment of blood-brain barrier|ion transport|lipid transport|cell differentiation|phospholipid transport|anion transport|organic anion transport|symporter activity|lipid transport across blood brain barrier|fatty acid transport|carboxylic acid transport|monocarboxylic acid transport - - - - 1:39955112-39969968 110 124 141 45 58 44 1.12686795496635 1.15447146383847 1.30231306477893 0.413040143372845 0.487503861863738 0.42243669520226 1.19455082786125 0.440993566812948 1.43763872633801 6.91515674446229e-08 1.09636266303334e-06 UP ENSG00000151835 SACS sacsin molecular chaperone [Source:HGNC Symbol;Acc:HGNC:10519] GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0016043|GO:0006457|GO:0043227|GO:0005622|GO:0005515|GO:0051128|GO:0022607|GO:0043231|GO:0051087|GO:0090083|GO:0005737|GO:0032403|GO:0043005|GO:0036477|GO:0031072|GO:0030424|GO:0070852|GO:0030544|GO:0030425|GO:0005739|GO:0070628|GO:0005634|GO:0090084 cell|cellular process|binding|cell projection|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|cellular component organization|protein folding|membrane-bounded organelle|intracellular|protein binding|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|chaperone binding|regulation of inclusion body assembly|cytoplasm|protein complex binding|neuron projection|somatodendritic compartment|heat shock protein binding|axon|cell body fiber|Hsp70 protein binding|dendrite|mitochondrion|proteasome binding|nucleus|negative regulation of inclusion body assembly - - - - 13:23328823-23433728 125 138 239 58 61 60 0.275515721954584 0.27643559925565 0.474950528503691 0.114540903460952 0.110315200435398 0.123940994606796 0.342300616571308 0.116265699501049 1.55783835274602 7.02420496187644e-08 1.11306058881029e-06 UP ENSG00000118523 CTGF connective tissue growth factor [Source:HGNC Symbol;Acc:HGNC:2500] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0005578|GO:0006807|GO:0006950|GO:0016049|GO:0001502|GO:0044089|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009893|GO:0009058|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0044255|GO:0008201|GO:0035988|GO:0045595|GO:0006725|GO:0009888|GO:0008022|GO:0019838|GO:0050867|GO:0006810|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0005938|GO:0007275|GO:0030324|GO:0048513|GO:0005102|GO:0034641|GO:0043168|GO:0043062|GO:0044281|GO:0032940|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0010942|GO:0045597|GO:0043231|GO:0010243|GO:0005737|GO:0032970|GO:0003012|GO:0007267|GO:0009611|GO:0006928|GO:0009887|GO:0032403|GO:0042592|GO:0072593|GO:0001775|GO:0031589|GO:0009966|GO:1903524|GO:0050839|GO:0001968|GO:0045787|GO:0030323|GO:0048871|GO:0060548|GO:0032231|GO:0044236|GO:0010646|GO:0006139|GO:0043085|GO:0001525|GO:0050865|GO:0007154|GO:0006629|GO:0016477|GO:0007165|GO:0032233|GO:0001503|GO:0009725|GO:0008219|GO:0050790|GO:0034059|GO:0048869|GO:0030029|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0005539|GO:0010033|GO:0001558|GO:0031323|GO:0003013|GO:0005794|GO:0006996|GO:0007568|GO:0071774|GO:0051017|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0048705|GO:0009743|GO:0044259|GO:0010468|GO:0006936|GO:0034645|GO:0051216|GO:0005520|GO:0090068|GO:0010712|GO:0007166|GO:0032956|GO:0033993|GO:0001944|GO:0043412|GO:0007010|GO:0072358|GO:0032964|GO:0051345|GO:0010629|GO:0001894|GO:0060541|GO:0045823|GO:1901652|GO:0005801|GO:0090257|GO:0045989|GO:0010628|GO:0043200|GO:0010260|GO:0036211|GO:0007160|GO:0005178|GO:0006811|GO:0032330|GO:0031098|GO:0043434|GO:0044344|GO:0010564|GO:0051247|GO:0048471|GO:0070848|GO:0006508|GO:0006259|GO:0030036|GO:0070542|GO:0045023|GO:0032270|GO:0012501|GO:0014070|GO:0070278|GO:0060429|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0046903|GO:0071310|GO:0030198|GO:0051246|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0061035|GO:0051496|GO:0043068|GO:0010714|GO:1902531|GO:0016070|GO:0008083|GO:0072359|GO:0008015|GO:0010557|GO:0051492|GO:0043067|GO:0048545|GO:0097305|GO:0010638|GO:0006941|GO:0008016|GO:0070304|GO:0070318|GO:0031401|GO:0008543|GO:0043065|GO:0006937|GO:0043408|GO:0002062|GO:0032774|GO:0060047|GO:0030162|GO:0006812|GO:0034284|GO:0045862|GO:0071363|GO:0016310|GO:0007229|GO:0043627|GO:0032967|GO:0052547|GO:0070371|GO:0008544|GO:0060452|GO:0051493|GO:0007167|GO:0043410|GO:0032355|GO:0032872|GO:0042981|GO:0031032|GO:0030038|GO:0006464|GO:0007015|GO:0051495|GO:0010952|GO:0031960|GO:0051403|GO:0071897|GO:0006351|GO:0006915|GO:0032963|GO:0006366|GO:0010950|GO:0006352|GO:0046328|GO:0043281|GO:0006468|GO:0006942|GO:0060048|GO:0042325|GO:0070374|GO:0007254|GO:0001932|GO:0051385|GO:0043149|GO:0055117|GO:0030001|GO:0032874|GO:0043280|GO:0001934|GO:0070372|GO:0061572|GO:0042327|GO:0007169|GO:0052548|GO:0006367|GO:0046330|GO:2001056|GO:0009749|GO:2000116|GO:0006816|GO:0060401 locomotion|developmental process|extracellular matrix|growth|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|response to stress|cell growth|cartilage condensation|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|positive regulation of metabolic process|biosynthetic process|extracellular space|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular lipid metabolic process|heparin binding|chondrocyte proliferation|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|protein C-terminus binding|growth factor binding|positive regulation of cell activation|transport|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|cell cortex|multicellular organism development|lung development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|anion binding|extracellular structure organization|small molecule metabolic process|secretion by cell|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|positive regulation of cell death|positive regulation of cell differentiation|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|muscle system process|cell-cell signaling|response to wounding|movement of cell or subcellular component|organ morphogenesis|protein complex binding|homeostatic process|reactive oxygen species metabolic process|cell activation|cell-substrate adhesion|regulation of signal transduction|positive regulation of blood circulation|cell adhesion molecule binding|fibronectin binding|positive regulation of cell cycle|respiratory tube development|multicellular organismal homeostasis|negative regulation of cell death|regulation of actin filament bundle assembly|multicellular organism metabolic process|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|angiogenesis|regulation of cell activation|cell communication|lipid metabolic process|cell migration|signal transduction|positive regulation of actin filament bundle assembly|ossification|response to hormone|cell death|regulation of catalytic activity|response to anoxia|cellular developmental process|actin filament-based process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|glycosaminoglycan binding|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|circulatory system process|Golgi apparatus|organelle organization|aging|response to fibroblast growth factor|actin filament bundle assembly|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|skeletal system morphogenesis|response to carbohydrate|multicellular organismal macromolecule metabolic process|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|cartilage development|insulin-like growth factor binding|positive regulation of cell cycle process|regulation of collagen metabolic process|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|response to lipid|vasculature development|macromolecule modification|cytoskeleton organization|cardiovascular system development|collagen biosynthetic process|positive regulation of hydrolase activity|negative regulation of gene expression|tissue homeostasis|respiratory system development|positive regulation of heart contraction|response to peptide|cis-Golgi network|regulation of muscle system process|positive regulation of striated muscle contraction|positive regulation of gene expression|response to amino acid|organ senescence|protein modification process|cell-matrix adhesion|integrin binding|ion transport|regulation of chondrocyte differentiation|stress-activated protein kinase signaling cascade|response to peptide hormone|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|perinuclear region of cytoplasm|response to growth factor|proteolysis|DNA metabolic process|actin cytoskeleton organization|response to fatty acid|G0 to G1 transition|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|extracellular matrix constituent secretion|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|secretion|cellular response to organic substance|extracellular matrix organization|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|regulation of cartilage development|positive regulation of stress fiber assembly|positive regulation of programmed cell death|positive regulation of collagen metabolic process|regulation of intracellular signal transduction|RNA metabolic process|growth factor activity|circulatory system development|blood circulation|positive regulation of macromolecule biosynthetic process|regulation of stress fiber assembly|regulation of programmed cell death|response to steroid hormone|response to alcohol|positive regulation of organelle organization|striated muscle contraction|regulation of heart contraction|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of G0 to G1 transition|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|positive regulation of apoptotic process|regulation of muscle contraction|regulation of MAPK cascade|chondrocyte differentiation|RNA biosynthetic process|heart contraction|regulation of proteolysis|cation transport|response to monosaccharide|positive regulation of proteolysis|cellular response to growth factor stimulus|phosphorylation|integrin-mediated signaling pathway|response to estrogen|positive regulation of collagen biosynthetic process|regulation of peptidase activity|ERK1 and ERK2 cascade|epidermis development|positive regulation of cardiac muscle contraction|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|response to estradiol|regulation of stress-activated MAPK cascade|regulation of apoptotic process|actomyosin structure organization|contractile actin filament bundle assembly|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|positive regulation of peptidase activity|response to corticosteroid|stress-activated MAPK cascade|DNA biosynthetic process|transcription, DNA-templated|apoptotic process|collagen metabolic process|transcription from RNA polymerase II promoter|positive regulation of endopeptidase activity|DNA-templated transcription, initiation|regulation of JNK cascade|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|regulation of striated muscle contraction|cardiac muscle contraction|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|JNK cascade|regulation of protein phosphorylation|response to mineralocorticoid|stress fiber assembly|regulation of cardiac muscle contraction|metal ion transport|positive regulation of stress-activated MAPK cascade|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|actin filament bundle organization|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|transcription initiation from RNA polymerase II promoter|positive regulation of JNK cascade|positive regulation of cysteine-type endopeptidase activity|response to glucose|regulation of cysteine-type endopeptidase activity|calcium ion transport|cytosolic calcium ion transport K06827 connective tissue growth factor[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) 6:131948176-131951373 53 48 109 6 15 21 1.60284073904446 1.31927768268291 2.97205677501386 0.162584487234292 0.37221021191607 0.595186697919146 1.96472506558041 0.376660465689836 2.38299092165725 7.03387022657942e-08 1.11400085805996e-06 UP ENSG00000121621 KIF18A kinesin family member 18A [Source:HGNC Symbol;Acc:HGNC:29441] GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0019882|GO:0043229|GO:0006950|GO:0044702|GO:0051321|GO:0043167|GO:0051641|GO:0003006|GO:0016043|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0045137|GO:0007049|GO:0050817|GO:0032182|GO:0051640|GO:0019884|GO:0006810|GO:0022402|GO:0035295|GO:0044853|GO:0007275|GO:0048513|GO:0043168|GO:0005874|GO:0000776|GO:0001882|GO:0051128|GO:0016817|GO:0043231|GO:0048608|GO:0005737|GO:0009611|GO:0032886|GO:0001726|GO:0006928|GO:0032403|GO:0051656|GO:0007548|GO:0045184|GO:0005875|GO:0008104|GO:0008406|GO:0007154|GO:0007165|GO:0007126|GO:0051649|GO:0008092|GO:0002504|GO:0007059|GO:0048002|GO:0000166|GO:0007017|GO:0098857|GO:0050878|GO:0006996|GO:0051276|GO:0005901|GO:0015631|GO:0005829|GO:0000819|GO:0008584|GO:0005871|GO:0035639|GO:1903047|GO:0046661|GO:0007080|GO:0007010|GO:0061458|GO:0070507|GO:0043130|GO:0007596|GO:0005815|GO:0001883|GO:0003779|GO:0015031|GO:0008017|GO:0016818|GO:0000278|GO:0051233|GO:0042060|GO:0032549|GO:0007140|GO:0007599|GO:0007018|GO:0005876|GO:0005694|GO:0072520|GO:0035556|GO:0033043|GO:0007067|GO:0017076|GO:0045121|GO:0000226|GO:0005856|GO:0005634|GO:0005819|GO:0051303|GO:0002495|GO:0046546|GO:0043241|GO:0072686|GO:0051010|GO:0005524|GO:0030554|GO:1990023|GO:0051493|GO:0019886|GO:0015630|GO:0031109|GO:0000070|GO:0051310|GO:0005828|GO:0007264|GO:0016462|GO:0000775|GO:0007019|GO:0043624|GO:0017111|GO:0016887|GO:0003774|GO:0051261|GO:0042623|GO:0003777|GO:0008574|GO:0070463 developmental process|macromolecular complex|reproduction|immune system process|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|antigen processing and presentation|intracellular organelle|response to stress|single organism reproductive process|meiotic cell cycle|ion binding|cellular localization|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|development of primary sexual characteristics|cell cycle|coagulation|ubiquitin-like protein binding|organelle localization|antigen processing and presentation of exogenous antigen|transport|cell cycle process|tube development|plasma membrane raft|multicellular organism development|animal organ development|anion binding|microtubule|kinetochore|nucleoside binding|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|response to wounding|regulation of microtubule-based process|ruffle|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|sex differentiation|establishment of protein localization|microtubule associated complex|protein localization|gonad development|cell communication|signal transduction|meiotic nuclear division|establishment of localization in cell|cytoskeletal protein binding|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|chromosome segregation|antigen processing and presentation of peptide antigen|nucleotide binding|microtubule-based process|membrane microdomain|regulation of body fluid levels|organelle organization|chromosome organization|caveola|tubulin binding|cytosol|sister chromatid segregation|male gonad development|kinesin complex|purine ribonucleoside triphosphate binding|mitotic cell cycle process|male sex differentiation|mitotic metaphase plate congression|cytoskeleton organization|reproductive system development|regulation of microtubule cytoskeleton organization|ubiquitin binding|blood coagulation|microtubule organizing center|purine nucleoside binding|actin binding|protein transport|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|spindle midzone|wound healing|ribonucleoside binding|male meiosis|hemostasis|microtubule-based movement|spindle microtubule|chromosome|seminiferous tubule development|intracellular signal transduction|regulation of organelle organization|mitotic nuclear division|purine nucleotide binding|membrane raft|microtubule cytoskeleton organization|cytoskeleton|nucleus|spindle|establishment of chromosome localization|antigen processing and presentation of peptide antigen via MHC class II|development of primary male sexual characteristics|protein complex disassembly|mitotic spindle|microtubule plus-end binding|ATP binding|adenyl nucleotide binding|mitotic spindle midzone|regulation of cytoskeleton organization|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule cytoskeleton|microtubule polymerization or depolymerization|mitotic sister chromatid segregation|metaphase plate congression|kinetochore microtubule|small GTPase mediated signal transduction|pyrophosphatase activity|chromosome, centromeric region|microtubule depolymerization|cellular protein complex disassembly|nucleoside-triphosphatase activity|ATPase activity|motor activity|protein depolymerization|ATPase activity, coupled|microtubule motor activity|ATP-dependent microtubule motor activity, plus-end-directed|tubulin-dependent ATPase activity - - - - 11:28020620-28108308 251 314 405 797 848 701 3.1592442280873 3.59185282078787 4.59598046280333 8.98804989235375 8.75735668644507 8.26906768684408 3.7823591705595 8.67149142188097 -1.19699377866724 7.0614597912959e-08 1.11777741574416e-06 DOWN ENSG00000177602 GSG2 germ cell associated 2 (haspin) [Source:HGNC Symbol;Acc:HGNC:19682] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0051726|GO:0007049|GO:0022402|GO:0016570|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0008104|GO:0007154|GO:0007165|GO:0007059|GO:0000166|GO:0019538|GO:0006996|GO:0051276|GO:0005813|GO:0000819|GO:0000075|GO:0035639|GO:1903047|GO:0043412|GO:0016572|GO:0006325|GO:0005815|GO:0001883|GO:0036211|GO:0000278|GO:0032549|GO:0007062|GO:0010564|GO:0005694|GO:0016301|GO:0034613|GO:0006796|GO:0035556|GO:0044267|GO:0007067|GO:0031503|GO:0017076|GO:0016773|GO:0005856|GO:0005634|GO:0005819|GO:0031577|GO:0033365|GO:0005524|GO:0007064|GO:0030554|GO:0016310|GO:0034629|GO:0015630|GO:0000070|GO:0004672|GO:0016568|GO:0006464|GO:1901976|GO:0090231|GO:0034502|GO:0072355|GO:0035173|GO:0006468|GO:0018193|GO:0072356|GO:0004674|GO:0071459|GO:0018107|GO:2000751|GO:0072354|GO:0034501 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|transferase activity|regulation of cell cycle|cell cycle|cell cycle process|histone modification|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|protein localization|cell communication|signal transduction|chromosome segregation|nucleotide binding|protein metabolic process|organelle organization|chromosome organization|centrosome|sister chromatid segregation|cell cycle checkpoint|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|histone phosphorylation|chromatin organization|microtubule organizing center|purine nucleoside binding|protein modification process|mitotic cell cycle|ribonucleoside binding|sister chromatid cohesion|regulation of cell cycle process|chromosome|kinase activity|cellular protein localization|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|mitotic nuclear division|protein complex localization|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|spindle|spindle checkpoint|protein localization to organelle|ATP binding|mitotic sister chromatid cohesion|adenyl nucleotide binding|phosphorylation|cellular protein complex localization|microtubule cytoskeleton|mitotic sister chromatid segregation|protein kinase activity|chromatin modification|cellular protein modification process|regulation of cell cycle checkpoint|regulation of spindle checkpoint|protein localization to chromosome|histone H3-T3 phosphorylation|histone kinase activity|protein phosphorylation|peptidyl-amino acid modification|chromosome passenger complex localization to kinetochore|protein serine/threonine kinase activity|protein localization to chromosome, centromeric region|peptidyl-threonine phosphorylation|histone H3-T3 phosphorylation involved in chromosome passenger complex localization to kinetochore|histone kinase activity (H3-T3 specific)|protein localization to kinetochore - - - - 17:3723903-3726699 759 774 616 326 391 325 19.1953017744873 17.7899294453041 14.0458629977367 7.38700488004849 8.11329977744444 7.70309148526051 17.010364739176 7.73446538091781 1.13704059709105 7.06967103338584e-08 1.11848414960626e-06 UP ENSG00000064042 LIMCH1 LIM and calponin homology domains 1 [Source:HGNC Symbol;Acc:HGNC:29191] GO:0009987|GO:0005488|GO:0043167|GO:0016043|GO:0005515|GO:0043169|GO:0008092|GO:0030029|GO:0006996|GO:0046872|GO:0007010|GO:0003779|GO:0030036|GO:0046914|GO:0031032|GO:0008270 cellular process|binding|ion binding|cellular component organization|protein binding|cation binding|cytoskeletal protein binding|actin filament-based process|organelle organization|metal ion binding|cytoskeleton organization|actin binding|actin cytoskeleton organization|transition metal ion binding|actomyosin structure organization|zinc ion binding - - - - 4:41359607-41700044 1329 1305 3418 6054 6051 8388 3.47423205773547 3.10044792812592 8.05601493457626 14.179930145347 12.978637477865 20.5504506379096 4.87689830681255 15.9030060870405 -1.70526370395876 7.22779485294538e-08 1.1422900346206e-06 DOWN ENSG00000162337 LRP5 LDL receptor related protein 5 [Source:HGNC Symbol;Acc:HGNC:6697] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0038023|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0045595|GO:0035239|GO:0060033|GO:0006725|GO:0060041|GO:0009888|GO:0048468|GO:0006810|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0061178|GO:0007275|GO:0033687|GO:0045596|GO:0048513|GO:0061299|GO:0030279|GO:0051302|GO:0034641|GO:0044281|GO:0032940|GO:0031325|GO:0046483|GO:0051128|GO:1902742|GO:0045597|GO:0043231|GO:0004888|GO:0005737|GO:0007389|GO:0001763|GO:0007267|GO:0007423|GO:0032880|GO:0043235|GO:0005975|GO:0006928|GO:0009887|GO:0042592|GO:0009966|GO:0048729|GO:0048598|GO:0045184|GO:0048771|GO:0046883|GO:0019725|GO:0045787|GO:0060561|GO:0010646|GO:0006139|GO:0001525|GO:0008104|GO:0007154|GO:0044092|GO:0006629|GO:0016477|GO:0007165|GO:0005783|GO:0030278|GO:0035426|GO:0001503|GO:0051649|GO:0017147|GO:0008219|GO:0060348|GO:0008217|GO:0050790|GO:0051781|GO:0034103|GO:0051301|GO:0043086|GO:0010817|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0019827|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0048732|GO:0003013|GO:0006996|GO:0051090|GO:0072089|GO:0016192|GO:0032268|GO:0030111|GO:0048705|GO:0009743|GO:0030879|GO:0010468|GO:0046850|GO:0034645|GO:0033688|GO:0090068|GO:0045668|GO:0042733|GO:0007166|GO:0001654|GO:0090276|GO:0002009|GO:0001569|GO:1903047|GO:0001944|GO:0043412|GO:0072358|GO:0010623|GO:0048878|GO:0009798|GO:0051252|GO:0006066|GO:0048539|GO:0010463|GO:0048754|GO:0051223|GO:0045667|GO:0015031|GO:0061138|GO:0022612|GO:0009790|GO:0010628|GO:0001667|GO:0036211|GO:0032269|GO:0000278|GO:0070201|GO:0007369|GO:0042886|GO:0055082|GO:0001649|GO:0051091|GO:0046849|GO:0033690|GO:0003002|GO:0051046|GO:0045600|GO:0007346|GO:0060042|GO:0010564|GO:0009914|GO:0009306|GO:0005996|GO:0005739|GO:0016052|GO:0035019|GO:0008202|GO:0035773|GO:0060764|GO:0012501|GO:0060429|GO:0006796|GO:0033043|GO:0035108|GO:0044267|GO:0051174|GO:0007067|GO:0010467|GO:0060562|GO:0046903|GO:0071310|GO:0060349|GO:1902262|GO:0045598|GO:0031328|GO:0051246|GO:0030177|GO:0061298|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0060173|GO:0061304|GO:0016070|GO:0045931|GO:0072359|GO:0008015|GO:0010557|GO:0043067|GO:0002076|GO:2000648|GO:0060612|GO:0072091|GO:0042813|GO:0010638|GO:0050796|GO:0071322|GO:0002790|GO:0016055|GO:0019318|GO:0045893|GO:0030073|GO:0045444|GO:0001678|GO:0060603|GO:0060828|GO:0043010|GO:0060444|GO:0007088|GO:0032774|GO:2001141|GO:0034284|GO:0050708|GO:0016310|GO:0015833|GO:0002053|GO:0009953|GO:0016125|GO:0042981|GO:0009952|GO:0045840|GO:0001702|GO:0033673|GO:0055088|GO:0006897|GO:0009950|GO:0006464|GO:0061180|GO:0090263|GO:0042074|GO:0030326|GO:0060443|GO:0046879|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0048592|GO:0033500|GO:0010464|GO:0071333|GO:0042593|GO:0045944|GO:0006366|GO:0030072|GO:0045859|GO:0006469|GO:0006357|GO:0048593|GO:0006468|GO:1903506|GO:0006006|GO:0060070|GO:0042325|GO:0001932|GO:0044332|GO:0042326|GO:0008203|GO:0001933|GO:0055092|GO:0006007|GO:0071901|GO:0009749|GO:0071900|GO:0042632 locomotion|developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|signaling receptor activity|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|immune system development|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of cell differentiation|tube morphogenesis|anatomical structure regression|cellular aromatic compound metabolic process|retina development in camera-type eye|tissue development|cell development|transport|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|regulation of insulin secretion involved in cellular response to glucose stimulus|multicellular organism development|osteoblast proliferation|negative regulation of cell differentiation|animal organ development|retina vasculature morphogenesis in camera-type eye|negative regulation of ossification|regulation of cell division|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|apoptotic process involved in development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|pattern specification process|morphogenesis of a branching structure|cell-cell signaling|sensory organ development|regulation of protein localization|receptor complex|carbohydrate metabolic process|movement of cell or subcellular component|organ morphogenesis|homeostatic process|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|establishment of protein localization|tissue remodeling|regulation of hormone secretion|cellular homeostasis|positive regulation of cell cycle|apoptotic process involved in morphogenesis|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|protein localization|cell communication|negative regulation of molecular function|lipid metabolic process|cell migration|signal transduction|endoplasmic reticulum|regulation of ossification|extracellular matrix-cell signaling|ossification|establishment of localization in cell|Wnt-protein binding|cell death|bone development|regulation of blood pressure|regulation of catalytic activity|positive regulation of cell division|regulation of tissue remodeling|cell division|negative regulation of catalytic activity|regulation of hormone levels|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|circulatory system process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|stem cell proliferation|vesicle-mediated transport|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|skeletal system morphogenesis|response to carbohydrate|mammary gland development|regulation of gene expression|regulation of bone remodeling|cellular macromolecule biosynthetic process|regulation of osteoblast proliferation|positive regulation of cell cycle process|negative regulation of osteoblast differentiation|embryonic digit morphogenesis|cell surface receptor signaling pathway|eye development|regulation of peptide hormone secretion|morphogenesis of an epithelium|patterning of blood vessels|mitotic cell cycle process|vasculature development|macromolecule modification|cardiovascular system development|developmental programmed cell death|chemical homeostasis|axis specification|regulation of RNA metabolic process|alcohol metabolic process|bone marrow development|mesenchymal cell proliferation|branching morphogenesis of an epithelial tube|regulation of protein transport|regulation of osteoblast differentiation|protein transport|morphogenesis of a branching epithelium|gland morphogenesis|embryo development|positive regulation of gene expression|ameboidal-type cell migration|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of establishment of protein localization|gastrulation|amide transport|cellular chemical homeostasis|osteoblast differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|bone remodeling|positive regulation of osteoblast proliferation|regionalization|regulation of secretion|positive regulation of fat cell differentiation|regulation of mitotic cell cycle|retina morphogenesis in camera-type eye|regulation of cell cycle process|hormone transport|protein secretion|monosaccharide metabolic process|mitochondrion|carbohydrate catabolic process|somatic stem cell population maintenance|steroid metabolic process|insulin secretion involved in cellular response to glucose stimulus|cell-cell signaling involved in mammary gland development|programmed cell death|epithelium development|phosphate-containing compound metabolic process|regulation of organelle organization|limb morphogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|gene expression|epithelial tube morphogenesis|secretion|cellular response to organic substance|bone morphogenesis|apoptotic process involved in patterning of blood vessels|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|retina vasculature development in camera-type eye|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|limb development|retinal blood vessel morphogenesis|RNA metabolic process|positive regulation of mitotic cell cycle|circulatory system development|blood circulation|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|osteoblast development|positive regulation of stem cell proliferation|adipose tissue development|regulation of stem cell proliferation|Wnt-activated receptor activity|positive regulation of organelle organization|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|Wnt signaling pathway|hexose metabolic process|positive regulation of transcription, DNA-templated|insulin secretion|fat cell differentiation|cellular glucose homeostasis|mammary gland duct morphogenesis|regulation of canonical Wnt signaling pathway|camera-type eye development|branching involved in mammary gland duct morphogenesis|regulation of mitotic nuclear division|RNA biosynthetic process|regulation of RNA biosynthetic process|response to monosaccharide|regulation of protein secretion|phosphorylation|peptide transport|positive regulation of mesenchymal cell proliferation|dorsal/ventral pattern formation|sterol metabolic process|regulation of apoptotic process|anterior/posterior pattern specification|positive regulation of mitotic nuclear division|gastrulation with mouth forming second|negative regulation of kinase activity|lipid homeostasis|endocytosis|dorsal/ventral axis specification|cellular protein modification process|mammary gland epithelium development|positive regulation of canonical Wnt signaling pathway|cell migration involved in gastrulation|embryonic limb morphogenesis|mammary gland morphogenesis|hormone secretion|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|eye morphogenesis|carbohydrate homeostasis|regulation of mesenchymal cell proliferation|cellular response to glucose stimulus|glucose homeostasis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|regulation of protein kinase activity|negative regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|camera-type eye morphogenesis|protein phosphorylation|regulation of nucleic acid-templated transcription|glucose metabolic process|canonical Wnt signaling pathway|regulation of phosphorylation|regulation of protein phosphorylation|Wnt signaling pathway involved in dorsal/ventral axis specification|negative regulation of phosphorylation|cholesterol metabolic process|negative regulation of protein phosphorylation|sterol homeostasis|glucose catabolic process|negative regulation of protein serine/threonine kinase activity|response to glucose|regulation of protein serine/threonine kinase activity|cholesterol homeostasis K03068 low density lipoprotein receptor-related protein 5/6[-] hsa04310 Wnt signaling pathway - Homo sapiens (human) 11:68312609-68449275 1362 1526 2260 3549 4237 5233 11.9562693571514 12.1745525777229 17.8871506086825 27.9140044543968 30.5172136473567 43.0524801332027 14.0059908478523 33.8278994116521 -1.27216954397987 7.24197007337883e-08 1.14392473317805e-06 DOWN ENSG00000151748 SAV1 salvador family WW domain containing protein 1 [Source:HGNC Symbol;Acc:HGNC:17795] GO:0032502|GO:0040007|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0032947|GO:0044237|GO:0045926|GO:0009653|GO:0043227|GO:0040008|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0007507|GO:0042127|GO:0048565|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:1901360|GO:0010941|GO:0007275|GO:0030324|GO:0060411|GO:0048513|GO:0034641|GO:0046620|GO:0031325|GO:0046483|GO:0046621|GO:0010942|GO:0035265|GO:0061061|GO:0055017|GO:0045597|GO:0043231|GO:0048635|GO:0001942|GO:2000036|GO:0005737|GO:0009887|GO:0050673|GO:0030323|GO:1901862|GO:0006139|GO:0007154|GO:0007165|GO:0031647|GO:0048638|GO:0003279|GO:0008219|GO:0008285|GO:0048640|GO:0048869|GO:0044249|GO:0019827|GO:0031323|GO:0051090|GO:0003205|GO:0060575|GO:0060043|GO:0005829|GO:0060479|GO:0010468|GO:0034645|GO:0055123|GO:2000736|GO:0072358|GO:0050821|GO:0022405|GO:0051252|GO:0060541|GO:0048738|GO:0003007|GO:0060420|GO:0010628|GO:0060412|GO:0060537|GO:0045843|GO:0051091|GO:0003231|GO:0045600|GO:0060044|GO:0050678|GO:0050680|GO:0043588|GO:0060038|GO:0012501|GO:0060429|GO:0035556|GO:0010467|GO:0045598|GO:0031328|GO:0009059|GO:0030154|GO:0003281|GO:0043068|GO:0007517|GO:0016070|GO:0072359|GO:0060428|GO:0010557|GO:0005634|GO:0043067|GO:0042633|GO:0016202|GO:0055024|GO:0045893|GO:0048863|GO:0045444|GO:0043065|GO:0030855|GO:0060487|GO:0032774|GO:0030216|GO:2001141|GO:0008544|GO:0035329|GO:0042981|GO:0014706|GO:0006351|GO:0006915|GO:0006355|GO:0098773|GO:0055026|GO:1903506|GO:0009913 developmental process|growth|structural molecule activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|protein complex scaffold|cellular metabolic process|negative regulation of growth|anatomical structure morphogenesis|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|anatomical structure development|regulation of metabolic process|heart development|regulation of cell proliferation|digestive tract development|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|tube development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|lung development|cardiac septum morphogenesis|animal organ development|cellular nitrogen compound metabolic process|regulation of organ growth|positive regulation of cellular metabolic process|heterocycle metabolic process|negative regulation of organ growth|positive regulation of cell death|organ growth|muscle structure development|cardiac muscle tissue growth|positive regulation of cell differentiation|intracellular membrane-bounded organelle|negative regulation of muscle organ development|hair follicle development|regulation of stem cell population maintenance|cytoplasm|organ morphogenesis|epithelial cell proliferation|respiratory tube development|negative regulation of muscle tissue development|nucleobase-containing compound metabolic process|cell communication|signal transduction|regulation of protein stability|regulation of developmental growth|cardiac septum development|cell death|negative regulation of cell proliferation|negative regulation of developmental growth|cellular developmental process|cellular biosynthetic process|stem cell population maintenance|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|cardiac chamber development|intestinal epithelial cell differentiation|regulation of cardiac muscle cell proliferation|cytosol|lung cell differentiation|regulation of gene expression|cellular macromolecule biosynthetic process|digestive system development|regulation of stem cell differentiation|cardiovascular system development|protein stabilization|hair cycle process|regulation of RNA metabolic process|respiratory system development|cardiac muscle tissue development|heart morphogenesis|regulation of heart growth|positive regulation of gene expression|ventricular septum morphogenesis|muscle tissue development|negative regulation of striated muscle tissue development|positive regulation of sequence-specific DNA binding transcription factor activity|cardiac ventricle development|positive regulation of fat cell differentiation|negative regulation of cardiac muscle cell proliferation|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|skin development|cardiac muscle cell proliferation|programmed cell death|epithelium development|intracellular signal transduction|gene expression|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|ventricular septum development|positive regulation of programmed cell death|muscle organ development|RNA metabolic process|circulatory system development|lung epithelium development|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|hair cycle|regulation of striated muscle tissue development|regulation of cardiac muscle tissue development|positive regulation of transcription, DNA-templated|stem cell differentiation|fat cell differentiation|positive regulation of apoptotic process|epithelial cell differentiation|lung epithelial cell differentiation|RNA biosynthetic process|keratinocyte differentiation|regulation of RNA biosynthetic process|epidermis development|hippo signaling|regulation of apoptotic process|striated muscle tissue development|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|skin epidermis development|negative regulation of cardiac muscle tissue development|regulation of nucleic acid-templated transcription|epidermal cell differentiation K16686 scaffold protein salvador[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) 14:50632058-50668331 1892 1797 2792 788 1231 1097 16.3292007841782 14.0952213225204 21.7256851559805 6.0935144925174 8.71705352855714 8.87317707908231 17.3833690875597 7.89458170005228 1.13877298835669 7.26353032113009e-08 1.14672360765213e-06 UP ENSG00000144451 SPAG16 sperm associated antigen 16 [Source:HGNC Symbol;Acc:HGNC:23225] GO:0040011|GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0043229|GO:0044702|GO:0019953|GO:0003006|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0032504|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0048609|GO:0001539|GO:0048468|GO:0005930|GO:0022607|GO:0043231|GO:0031514|GO:0019899|GO:0005737|GO:0006928|GO:0048515|GO:0097231|GO:0007276|GO:0030030|GO:0048869|GO:0010035|GO:0007288|GO:0007017|GO:0007281|GO:0060294|GO:0006996|GO:0000902|GO:0007286|GO:0048232|GO:0060285|GO:0007010|GO:0035082|GO:1990716|GO:0010038|GO:0044782|GO:0030031|GO:0007018|GO:0070925|GO:0019900|GO:0042384|GO:0071241|GO:0032990|GO:0030154|GO:0048858|GO:0000226|GO:0005856|GO:0005634|GO:0060271|GO:0007283|GO:0051592|GO:0051012|GO:0001578|GO:0019901|GO:0071248|GO:0003341|GO:0071277 locomotion|developmental process|reproduction|cell|cellular process|reproductive process|response to stimulus|binding|cellular response to stimulus|cell projection|intracellular organelle|single organism reproductive process|sexual reproduction|developmental process involved in reproduction|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|cilium or flagellum-dependent cell motility|cell development|axoneme|cellular component assembly|intracellular membrane-bounded organelle|motile cilium|enzyme binding|cytoplasm|movement of cell or subcellular component|spermatid differentiation|cell motility in response to calcium ion|gamete generation|cell projection organization|cellular developmental process|response to inorganic substance|sperm axoneme assembly|microtubule-based process|germ cell development|cilium movement involved in cell motility|organelle organization|cell morphogenesis|spermatid development|male gamete generation|cilium-dependent cell motility|cytoskeleton organization|axoneme assembly|axonemal central apparatus|response to metal ion|cilium organization|cell projection assembly|microtubule-based movement|organelle assembly|kinase binding|cilium assembly|cellular response to inorganic substance|cell part morphogenesis|cell differentiation|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|nucleus|cilium morphogenesis|spermatogenesis|response to calcium ion|microtubule sliding|microtubule bundle formation|protein kinase binding|cellular response to metal ion|cilium movement|cellular response to calcium ion - - - - 2:213284379-214410501 48 40 119 244 283 301 0.338620080124635 0.256456775023714 0.756898505707047 1.54227736016469 1.63805750491691 1.99008157591579 0.450658453618465 1.72347214699913 -1.93521162485779 7.27993073114397e-08 1.14870534908865e-06 DOWN ENSG00000189227 C15orf61 chromosome 15 open reading frame 61 [Source:HGNC Symbol;Acc:HGNC:34453] GO:0005576 extracellular region - - - - 15:67521068-67530143 242 237 238 99 109 105 2.74904727233703 2.44678352615984 2.43757441546417 1.00762485857307 1.01592421764807 1.11784960103826 2.54446840465368 1.0471328924198 1.28091972969889 7.29668654999994e-08 1.15074104735181e-06 UP ENSG00000117419 ERI3 ERI1 exoribonuclease family member 3 [Source:HGNC Symbol;Acc:HGNC:17276] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043169|GO:0006139|GO:0046872|GO:0003723|GO:0004518|GO:0006259|GO:0004527|GO:0044822|GO:0090305 cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cation binding|nucleobase-containing compound metabolic process|metal ion binding|RNA binding|nuclease activity|DNA metabolic process|exonuclease activity|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis - - - - 1:44221070-44355260 353 427 494 949 1203 859 5.34920893044301 5.88061448423748 6.74926236206761 12.884834918639 14.9571332056297 12.1993525002679 5.99302859224937 13.3471068748455 -1.15516989452844 7.33779631617284e-08 1.1566133644299e-06 DOWN ENSG00000268568 AC007228.9 - - - - - - - 19:56672574-56673901 42 41 50 12 12 12 2.23715524527163 1.98479654359919 2.40123181587495 0.572718547652121 0.524448888755695 0.599020678676972 2.20772786824859 0.565396038361596 1.96522867218325 7.38851834335201e-08 1.16399380803394e-06 UP ENSG00000170881 RNF139 ring finger protein 139 [Source:HGNC Symbol;Acc:HGNC:17023] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0016874|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0060341|GO:0042127|GO:0036513|GO:0006810|GO:0060627|GO:0034641|GO:0031325|GO:0033554|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0009890|GO:0005783|GO:0031647|GO:0051649|GO:0008285|GO:0019787|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0036503|GO:0016192|GO:0032268|GO:0045732|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0043412|GO:0030163|GO:0010629|GO:0004842|GO:0032386|GO:0051604|GO:0044265|GO:0036211|GO:0032269|GO:0046907|GO:0002020|GO:0051247|GO:0006508|GO:0032270|GO:0043603|GO:0044267|GO:0042176|GO:0010467|GO:0031648|GO:0060628|GO:0051246|GO:0009059|GO:0034976|GO:0044257|GO:0043043|GO:0031401|GO:0061630|GO:0010498|GO:0016485|GO:0017148|GO:1903364|GO:0030162|GO:0045862|GO:0010608|GO:0048193|GO:0016482|GO:0006412|GO:0051603|GO:0006417|GO:0046914|GO:0006464|GO:1903052|GO:0019941|GO:0070613|GO:0006888|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0031398|GO:2000058|GO:0031396|GO:2000060|GO:0042787|GO:0016567|GO:0000209 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|ligase activity|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|regulation of cellular localization|regulation of cell proliferation|Derlin-1 retrotranslocation complex|transport|regulation of vesicle-mediated transport|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|negative regulation of biosynthetic process|endoplasmic reticulum|regulation of protein stability|establishment of localization in cell|negative regulation of cell proliferation|ubiquitin-like protein transferase activity|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|ERAD pathway|vesicle-mediated transport|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|macromolecule modification|protein catabolic process|negative regulation of gene expression|ubiquitin-protein transferase activity|regulation of intracellular transport|protein maturation|cellular macromolecule catabolic process|protein modification process|negative regulation of cellular protein metabolic process|intracellular transport|protease binding|positive regulation of protein metabolic process|proteolysis|positive regulation of cellular protein metabolic process|cellular amide metabolic process|cellular protein metabolic process|regulation of protein catabolic process|gene expression|protein destabilization|regulation of ER to Golgi vesicle-mediated transport|regulation of protein metabolic process|macromolecule biosynthetic process|response to endoplasmic reticulum stress|cellular protein catabolic process|peptide biosynthetic process|positive regulation of protein modification process|ubiquitin protein ligase activity|proteasomal protein catabolic process|protein processing|negative regulation of translation|positive regulation of cellular protein catabolic process|regulation of proteolysis|positive regulation of proteolysis|posttranscriptional regulation of gene expression|Golgi vesicle transport|cytosolic transport|translation|proteolysis involved in cellular protein catabolic process|regulation of translation|transition metal ion binding|cellular protein modification process|positive regulation of proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|regulation of protein processing|ER to Golgi vesicle-mediated transport|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein ubiquitination|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 8:124474738-124487914 1607 1549 2124 935 1020 828 36.6218116633823 32.0815667022448 43.6408005084637 19.0911976365048 19.0718166051897 17.6841197855316 37.4480596246969 18.6157113424087 1.00837022180312 7.41420244833612e-08 1.1674240500666e-06 UP ENSG00000137959 IFI44L interferon induced protein 44 like [Source:HGNC Symbol;Acc:HGNC:17817] GO:0002376|GO:0005623|GO:0050896|GO:0043229|GO:0006950|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0006952|GO:0098542|GO:0043231|GO:0005737|GO:0009615|GO:0051607|GO:0031981|GO:0005654|GO:0005634 immune system process|cell|response to stimulus|intracellular organelle|response to stress|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|defense response|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|response to virus|defense response to virus|nuclear lumen|nucleoplasm|nucleus - - - - 1:78619922-78646145 1 4 13 45 34 66 0.004965386852555 0.0180430261237916 0.0581729793559084 0.200115225230809 0.138456210892084 0.307004162849608 0.0270604641107517 0.215191866324167 -2.99136506079125 7.47756037755964e-08 1.17654099361201e-06 DOWN ENSG00000224950 RP5-1086K13.1 - - - - - - - 1:116493016-116499212 16 25 22 76 87 74 0.491660846272606 0.698181136678804 0.609491918146811 2.09242069656095 2.19343709321425 2.13109461716106 0.59977796703274 2.13898413564542 -1.83442535181154 7.4799852812876e-08 1.17654099361201e-06 DOWN ENSG00000148690 FRA10AC1 fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 [Source:HGNC Symbol;Acc:HGNC:1162] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|nucleus - - - - 10:93667883-93702572 100 91 152 277 360 392 0.69629762767605 0.575861296766728 0.954227474169259 1.72811172842591 2.05667419246798 2.55805256015198 0.742128799537346 2.11427949368196 -1.51042460460396 7.51278116797364e-08 1.18107724585932e-06 DOWN ENSG00000081913 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:20610] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0042752|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0007623|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0002507|GO:0009605|GO:0023057|GO:0016787|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0045087|GO:0010941|GO:0007275|GO:0016788|GO:0002517|GO:0006952|GO:0033554|GO:0043231|GO:0043169|GO:0002643|GO:0005737|GO:0009966|GO:0010646|GO:0050776|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0009649|GO:0071774|GO:0000165|GO:0032268|GO:0005829|GO:0046872|GO:0007166|GO:0043412|GO:0036211|GO:0031098|GO:0002664|GO:0044344|GO:0070848|GO:0002764|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:1902532|GO:0051246|GO:1902531|GO:0005634|GO:0042578|GO:0043067|GO:0051896|GO:0043491|GO:0002667|GO:0016311|GO:0051898|GO:0008543|GO:0043408|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0048017|GO:0007167|GO:0032872|GO:0042981|GO:0016791|GO:0006464|GO:0051403|GO:0006915|GO:0048011|GO:0006470|GO:0048015|GO:1900744|GO:0046328|GO:0038066|GO:0006468|GO:0042325|GO:0004721|GO:0007254|GO:0001932|GO:0038093|GO:0007169|GO:0038095|GO:0038127|GO:0007173 developmental process|immune system process|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|regulation of circadian rhythm|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|circadian rhythm|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|tolerance induction|response to external stimulus|negative regulation of signaling|hydrolase activity|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|innate immune response|regulation of cell death|multicellular organism development|hydrolase activity, acting on ester bonds|T cell tolerance induction|defense response|cellular response to stress|intracellular membrane-bounded organelle|cation binding|regulation of tolerance induction|cytoplasm|regulation of signal transduction|regulation of cell communication|regulation of immune response|cell communication|signal transduction|negative regulation of signal transduction|cell death|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|entrainment of circadian clock|response to fibroblast growth factor|MAPK cascade|regulation of cellular protein metabolic process|cytosol|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|protein modification process|stress-activated protein kinase signaling cascade|regulation of T cell tolerance induction|cellular response to fibroblast growth factor stimulus|response to growth factor|immune response-regulating signaling pathway|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|regulation of intracellular signal transduction|nucleus|phosphoric ester hydrolase activity|regulation of programmed cell death|regulation of protein kinase B signaling|protein kinase B signaling|regulation of T cell anergy|dephosphorylation|negative regulation of protein kinase B signaling|fibroblast growth factor receptor signaling pathway|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|regulation of stress-activated MAPK cascade|regulation of apoptotic process|phosphatase activity|cellular protein modification process|stress-activated MAPK cascade|apoptotic process|neurotrophin TRK receptor signaling pathway|protein dephosphorylation|phosphatidylinositol-mediated signaling|regulation of p38MAPK cascade|regulation of JNK cascade|p38MAPK cascade|protein phosphorylation|regulation of phosphorylation|phosphoprotein phosphatase activity|JNK cascade|regulation of protein phosphorylation|Fc receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|Fc-epsilon receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K16340 PH domain and leucine-rich repeat-containing protein phosphatase[3.1.3.16] hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) 18:62715450-62980433 105 106 234 469 463 479 0.751227727801787 0.689233743337854 1.50942284586917 3.00643532318386 2.7178770205086 3.21178228893495 0.98329477233627 2.9786982108758 -1.59898608524859 7.58103079452676e-08 1.19117943863054e-06 DOWN ENSG00000135521 LTV1 LTV1 ribosome biogenesis factor [Source:HGNC Symbol;Acc:HGNC:21173] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nuclear lumen|nucleoplasm|nucleus - - - - 6:143843344-143863812 1230 1320 782 481 538 290 47.1068350536685 45.9444290433152 27.0022568720677 16.5052150261986 16.9055399498804 10.4089137677596 40.0178403230171 14.6065562479462 1.45402723263876 7.60719373288149e-08 1.1946615555047e-06 UP ENSG00000275400 RP4-756H11.5 - - - - - - - 7:66553805-66554199 193 188 139 51 50 74 34.5625496911655 30.5975007363672 22.442824324823 8.18310710286203 7.34653850516732 12.4196957182399 29.2009582507852 9.31644710875642 1.6481639297869 7.65490056763576e-08 1.2015215643859e-06 UP ENSG00000271122 RP11-379H18.1 - - - - - - - 7:35695214-35699413 62 56 84 204 201 200 1.04420944896022 0.857164027720926 1.27552925500392 3.07839169150237 2.77753623502325 3.15686701846506 1.05896757722836 3.00426498166356 -1.50435364828421 7.69840209236684e-08 1.20771464038633e-06 DOWN ENSG00000130309 COLGALT1 collagen beta(1-O)galactosyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:26182] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0012505|GO:0016740|GO:0043062|GO:0043231|GO:0005737|GO:0005783|GO:0016757|GO:0008194|GO:0016758|GO:0005788|GO:0030198|GO:0008378|GO:0035250|GO:0050211 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|endomembrane system|transferase activity|extracellular structure organization|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|transferase activity, transferring glycosyl groups|UDP-glycosyltransferase activity|transferase activity, transferring hexosyl groups|endoplasmic reticulum lumen|extracellular matrix organization|galactosyltransferase activity|UDP-galactosyltransferase activity|procollagen galactosyltransferase activity K11703 collagen beta-1,O-galactosyltransferase[2.4.1.50] hsa00310|hsa00514 Lysine degradation - Homo sapiens (human)|Other types of O-glycan biosynthesis - Homo sapiens (human) 19:17555594-17583162 1274 1510 1856 3426 4010 3186 11.8312634417412 12.7443807060557 15.5401068769369 28.506694440704 30.554424419187 27.7291452109178 13.3719170082446 28.9300880236029 -1.11336440674187 7.71466343032317e-08 1.20963005277767e-06 DOWN ENSG00000132405 TBC1D14 TBC1 domain family member 14 [Source:HGNC Symbol;Acc:HGNC:29246] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0010507|GO:0010506|GO:1902115|GO:0006810|GO:0009991|GO:0008047|GO:0051128|GO:0033554|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0010646|GO:0043085|GO:0007154|GO:0051649|GO:0016236|GO:0050790|GO:0031324|GO:0031323|GO:0005794|GO:0005768|GO:0006996|GO:0016192|GO:0005096|GO:0051345|GO:0030695|GO:2000785|GO:0005773|GO:0046907|GO:0016241|GO:0055037|GO:0070925|GO:0019900|GO:0033043|GO:0000045|GO:0031667|GO:0007033|GO:0042147|GO:0043087|GO:0048193|GO:0044088|GO:0016482|GO:0043547|GO:0005776|GO:0016197|GO:0019901|GO:0071955 cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|catabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|endomembrane system|regulation of metabolic process|negative regulation of autophagy|regulation of autophagy|regulation of organelle assembly|transport|response to extracellular stimulus|enzyme activator activity|regulation of cellular component organization|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of cell communication|positive regulation of catalytic activity|cell communication|establishment of localization in cell|macroautophagy|regulation of catalytic activity|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|endosome|organelle organization|vesicle-mediated transport|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|regulation of autophagosome assembly|vacuole|intracellular transport|regulation of macroautophagy|recycling endosome|organelle assembly|kinase binding|regulation of organelle organization|autophagosome assembly|response to nutrient levels|vacuole organization|retrograde transport, endosome to Golgi|regulation of GTPase activity|Golgi vesicle transport|regulation of vacuole organization|cytosolic transport|positive regulation of GTPase activity|autophagosome|endosomal transport|protein kinase binding|recycling endosome to Golgi transport - - - - 4:6909242-7033118 542 621 777 1503 1709 1315 2.45781012651617 2.55929514813514 3.17675779271418 6.10668526818157 6.35856276091381 5.58860729969944 2.73128768912183 6.01795177626494 -1.13969126340641 7.74165680295259e-08 1.2132253133614e-06 DOWN ENSG00000130340 SNX9 sorting nexin 9 [Source:HGNC Symbol;Acc:HGNC:14973] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0019898|GO:0042995|GO:0044877|GO:0050794|GO:0043229|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0031252|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0042802|GO:0007049|GO:0009898|GO:0006810|GO:0022402|GO:0051130|GO:0043168|GO:0005543|GO:0031982|GO:0031325|GO:0051128|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0012506|GO:0001726|GO:0032403|GO:0031234|GO:0098562|GO:0046983|GO:0045184|GO:0019897|GO:0043085|GO:0008104|GO:0061024|GO:0070062|GO:0051649|GO:0050790|GO:0051301|GO:0019538|GO:0031334|GO:0043254|GO:0031323|GO:0010256|GO:0005794|GO:0005768|GO:0006996|GO:0016192|GO:0032268|GO:0045732|GO:0005802|GO:0016050|GO:1903047|GO:0043412|GO:0030163|GO:0031410|GO:0051345|GO:0071933|GO:0035091|GO:0015031|GO:0032461|GO:0007009|GO:0016023|GO:0051347|GO:0036211|GO:0000278|GO:0046907|GO:0032459|GO:0051247|GO:0006508|GO:0031988|GO:0006461|GO:0034613|GO:0032270|GO:0032506|GO:0006796|GO:0030659|GO:0044267|GO:0051174|GO:0042176|GO:0007067|GO:0051246|GO:0000910|GO:0042803|GO:0044389|GO:0031625|GO:0031401|GO:0034622|GO:0051259|GO:0036089|GO:0065005|GO:0030162|GO:0045862|GO:0043087|GO:0016310|GO:0005545|GO:0033619|GO:0006886|GO:0043547|GO:0030135|GO:0016197|GO:0051044|GO:0097320|GO:0006897|GO:0006464|GO:0000281|GO:0043549|GO:0033674|GO:0006509|GO:0030136|GO:0060988|GO:0045859|GO:0045860|GO:0006468|GO:0042325|GO:0001932|GO:0006898|GO:0001934|GO:0042327 cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|extrinsic component of membrane|cell projection|macromolecular complex binding|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|cell leading edge|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|identical protein binding|cell cycle|cytoplasmic side of plasma membrane|transport|cell cycle process|positive regulation of cellular component organization|anion binding|phospholipid binding|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|vesicle membrane|ruffle|protein complex binding|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|protein dimerization activity|establishment of protein localization|extrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|membrane organization|extracellular exosome|establishment of localization in cell|regulation of catalytic activity|cell division|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|endosome|organelle organization|vesicle-mediated transport|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|trans-Golgi network|vesicle organization|mitotic cell cycle process|macromolecule modification|protein catabolic process|cytoplasmic vesicle|positive regulation of hydrolase activity|Arp2/3 complex binding|phosphatidylinositol binding|protein transport|positive regulation of protein oligomerization|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|protein modification process|mitotic cell cycle|intracellular transport|regulation of protein oligomerization|positive regulation of protein metabolic process|proteolysis|membrane-bounded vesicle|protein complex assembly|cellular protein localization|positive regulation of cellular protein metabolic process|cytokinetic process|phosphate-containing compound metabolic process|cytoplasmic vesicle membrane|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|mitotic nuclear division|regulation of protein metabolic process|cytokinesis|protein homodimerization activity|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|positive regulation of protein modification process|cellular macromolecular complex assembly|protein oligomerization|cleavage furrow formation|protein-lipid complex assembly|regulation of proteolysis|positive regulation of proteolysis|regulation of GTPase activity|phosphorylation|1-phosphatidylinositol binding|membrane protein proteolysis|intracellular protein transport|positive regulation of GTPase activity|coated vesicle|endosomal transport|positive regulation of membrane protein ectodomain proteolysis|membrane tubulation|endocytosis|cellular protein modification process|mitotic cytokinesis|regulation of kinase activity|positive regulation of kinase activity|membrane protein ectodomain proteolysis|clathrin-coated vesicle|lipid tube assembly|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|receptor-mediated endocytosis|positive regulation of protein phosphorylation|positive regulation of phosphorylation - - - - 6:157700387-157945077 396 478 583 1154 1298 949 5.85776163664812 6.42605421227749 7.7753317572051 15.2946606892994 15.7535594832888 13.1562254787745 6.6863825353769 14.7348152171209 -1.13993116775128 7.80539021452513e-08 1.22257145574204e-06 DOWN ENSG00000204592 HLA-E major histocompatibility complex, class I, E [Source:HGNC Symbol;Acc:HGNC:4962] GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0050896|GO:0005488|GO:0033218|GO:0019882|GO:0006955|GO:0003823|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0042605|GO:0042277|GO:0098797|GO:0048002|GO:0016021|GO:0002474|GO:0042612 macromolecular complex|immune system process|cell|membrane|response to stimulus|binding|amide binding|antigen processing and presentation|immune response|antigen binding|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|protein complex|peptide antigen binding|peptide binding|plasma membrane protein complex|antigen processing and presentation of peptide antigen|integral component of membrane|antigen processing and presentation of peptide antigen via MHC class I|MHC class I protein complex - - - - 6:30489467-30494205 4330 4498 5152 2083 2164 2857 77.3851878902394 73.0582743424833 83.0156594486583 33.354689177438 31.7318335709914 47.8529910785816 77.819707227127 37.6465046090037 1.04761963240851 7.8216492608768e-08 1.2244757054757e-06 UP ENSG00000181773 GPR3 G protein-coupled receptor 3 [Source:HGNC Symbol;Acc:HGNC:4484] GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0044702|GO:0051321|GO:0038023|GO:0016043|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0051726|GO:0007049|GO:0022402|GO:0051302|GO:0051128|GO:0005887|GO:0004888|GO:0051445|GO:0031226|GO:0007154|GO:0007165|GO:0007126|GO:0051301|GO:0016021|GO:0006996|GO:0007186|GO:0040020|GO:0010564|GO:0033043|GO:0004930|GO:0007187|GO:0007188|GO:0007189 signal transducer activity|reproduction|signaling|cell|membrane|cellular process|reproductive process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|single organism reproductive process|meiotic cell cycle|signaling receptor activity|cellular component organization|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|regulation of cell cycle|cell cycle|cell cycle process|regulation of cell division|regulation of cellular component organization|integral component of plasma membrane|transmembrane signaling receptor activity|regulation of meiotic cell cycle|intrinsic component of plasma membrane|cell communication|signal transduction|meiotic nuclear division|cell division|integral component of membrane|organelle organization|G-protein coupled receptor signaling pathway|regulation of meiotic nuclear division|regulation of cell cycle process|regulation of organelle organization|G-protein coupled receptor activity|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway - - - - 1:27392644-27395814 60 78 109 20 34 23 2.00671988640028 2.37087922561107 3.28682779988531 0.599315808002198 0.932991923231198 0.720937916755897 2.55480897063222 0.751081882663098 1.76617331783475 7.87934381680529e-08 1.23221545472449e-06 UP ENSG00000189362 NEMP2 nuclear envelope integral membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:33700] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0019866|GO:0043231|GO:0005635|GO:0031965|GO:0016021|GO:0005637|GO:0005634 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|organelle inner membrane|intracellular membrane-bounded organelle|nuclear envelope|nuclear membrane|integral component of membrane|nuclear inner membrane|nucleus - - - - 2:190504342-190534722 34 53 40 158 170 116 0.310933892971611 0.440498698752237 0.329806765548132 1.29461591736518 1.27556636468879 0.994199573150733 0.36041311909066 1.18812728506823 -1.72096597001067 7.87844976630458e-08 1.23221545472449e-06 DOWN ENSG00000151414 NEK7 NIMA-related kinase 7 [Source:HGNC Symbol;Acc:HGNC:13386] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0016740|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:0051130|GO:1901360|GO:0034641|GO:0043168|GO:0005874|GO:0032204|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0032206|GO:0043231|GO:0000723|GO:0043169|GO:0005737|GO:0042592|GO:0006139|GO:0043085|GO:0050790|GO:0000166|GO:0051301|GO:0044249|GO:0007017|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0007004|GO:0034645|GO:0046872|GO:0010833|GO:0035639|GO:0043412|GO:0007010|GO:0005815|GO:0001883|GO:0051347|GO:0036211|GO:0000278|GO:1904358|GO:0032549|GO:0031981|GO:0007346|GO:0005654|GO:0006259|GO:0007051|GO:0006461|GO:0016301|GO:0070925|GO:0051054|GO:0006796|GO:0033043|GO:0044267|GO:0017076|GO:0031328|GO:1904355|GO:1904356|GO:0009059|GO:0016233|GO:0000226|GO:0016773|GO:0005856|GO:0000910|GO:0010557|GO:0000922|GO:0005634|GO:0005819|GO:0010638|GO:2001252|GO:0051225|GO:0032200|GO:0006260|GO:0051972|GO:0005524|GO:0051973|GO:0030554|GO:0016310|GO:0033044|GO:0032212|GO:2000278|GO:0015630|GO:0006275|GO:0004672|GO:2000573|GO:0045740|GO:0006464|GO:0071897|GO:0032210|GO:0006278|GO:0006468|GO:0004674 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|transferase activity|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|microtubule|regulation of telomere maintenance|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of telomere maintenance|intracellular membrane-bounded organelle|telomere maintenance|cation binding|cytoplasm|homeostatic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of catalytic activity|nucleotide binding|cell division|cellular biosynthetic process|microtubule-based process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|telomere maintenance via telomerase|cellular macromolecule biosynthetic process|metal ion binding|telomere maintenance via telomere lengthening|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|microtubule organizing center|purine nucleoside binding|positive regulation of transferase activity|protein modification process|mitotic cell cycle|positive regulation of telomere maintenance via telomere lengthening|ribonucleoside binding|nuclear lumen|regulation of mitotic cell cycle|nucleoplasm|DNA metabolic process|spindle organization|protein complex assembly|kinase activity|organelle assembly|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|purine nucleotide binding|positive regulation of cellular biosynthetic process|positive regulation of telomere capping|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|telomere capping|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|cytokinesis|positive regulation of macromolecule biosynthetic process|spindle pole|nucleus|spindle|positive regulation of organelle organization|positive regulation of chromosome organization|spindle assembly|telomere organization|DNA replication|regulation of telomerase activity|ATP binding|positive regulation of telomerase activity|adenyl nucleotide binding|phosphorylation|regulation of chromosome organization|positive regulation of telomere maintenance via telomerase|regulation of DNA biosynthetic process|microtubule cytoskeleton|regulation of DNA replication|protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|cellular protein modification process|DNA biosynthetic process|regulation of telomere maintenance via telomerase|RNA-dependent DNA replication|protein phosphorylation|protein serine/threonine kinase activity - - - - 1:198156963-198322420 644 698 961 2073 2494 1421 6.59255208234197 6.49386363249005 8.86962943307219 19.0136108883113 20.9474977055386 13.6329798836187 7.31868171596807 17.8646961591562 -1.28745566662836 7.88389010196941e-08 1.23228091677589e-06 DOWN ENSG00000126524 SBDS Shwachman-Bodian-Diamond syndrome [Source:HGNC Symbol;Acc:HGNC:19440] GO:0040011|GO:0032502|GO:0040007|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0050900|GO:0044237|GO:0048870|GO:0016043|GO:0043227|GO:0009605|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0051726|GO:0007049|GO:0001824|GO:0006935|GO:0006725|GO:0009888|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0043021|GO:0034641|GO:0046483|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0032886|GO:0006928|GO:0032403|GO:0001833|GO:0006139|GO:0016477|GO:0001503|GO:0008092|GO:0001832|GO:0060348|GO:0030595|GO:0022613|GO:0007017|GO:0006996|GO:0005730|GO:0015631|GO:0003723|GO:1903047|GO:0007010|GO:0070507|GO:0048539|GO:0031214|GO:0009790|GO:0042254|GO:0008017|GO:0000278|GO:0022618|GO:0031981|GO:0060326|GO:0043242|GO:0007346|GO:0010564|GO:0005654|GO:0043022|GO:0007051|GO:0043244|GO:0070925|GO:0033043|GO:0010467|GO:0001501|GO:0016070|GO:0000226|GO:0005856|GO:0000922|GO:0005634|GO:0030282|GO:0005819|GO:0006364|GO:0043241|GO:0009792|GO:0034622|GO:0006396|GO:0042255|GO:0019843|GO:0060236|GO:0034660|GO:0007052|GO:0031110|GO:0051494|GO:0051493|GO:0015630|GO:0043148|GO:0031109|GO:1901879|GO:0044822|GO:0007019|GO:0007026|GO:0043624|GO:0031111|GO:0042256|GO:0016072|GO:0043009|GO:0043146|GO:0001701|GO:0051261 locomotion|developmental process|growth|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|leukocyte migration|cellular metabolic process|cell motility|cellular component organization|membrane-bounded organelle|response to external stimulus|developmental growth|intracellular|immune system development|protein binding|anatomical structure development|regulation of cell cycle|cell cycle|blastocyst development|chemotaxis|cellular aromatic compound metabolic process|tissue development|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|ribonucleoprotein complex binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|regulation of microtubule-based process|movement of cell or subcellular component|protein complex binding|inner cell mass cell proliferation|nucleobase-containing compound metabolic process|cell migration|ossification|cytoskeletal protein binding|blastocyst growth|bone development|leukocyte chemotaxis|ribonucleoprotein complex biogenesis|microtubule-based process|organelle organization|nucleolus|tubulin binding|RNA binding|mitotic cell cycle process|cytoskeleton organization|regulation of microtubule cytoskeleton organization|bone marrow development|biomineral tissue development|embryo development|ribosome biogenesis|microtubule binding|mitotic cell cycle|ribonucleoprotein complex assembly|nuclear lumen|cell chemotaxis|negative regulation of protein complex disassembly|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|ribosome binding|spindle organization|regulation of protein complex disassembly|organelle assembly|regulation of organelle organization|gene expression|skeletal system development|RNA metabolic process|microtubule cytoskeleton organization|cytoskeleton|spindle pole|nucleus|bone mineralization|spindle|rRNA processing|protein complex disassembly|embryo development ending in birth or egg hatching|cellular macromolecular complex assembly|RNA processing|ribosome assembly|rRNA binding|regulation of mitotic spindle organization|ncRNA metabolic process|mitotic spindle organization|regulation of microtubule polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|microtubule cytoskeleton|mitotic spindle stabilization|microtubule polymerization or depolymerization|regulation of protein depolymerization|poly(A) RNA binding|microtubule depolymerization|negative regulation of microtubule depolymerization|cellular protein complex disassembly|negative regulation of microtubule polymerization or depolymerization|mature ribosome assembly|rRNA metabolic process|chordate embryonic development|spindle stabilization|in utero embryonic development|protein depolymerization K14574 ribosome maturation protein SDO1[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 7:66987677-66995601 2373 2726 1942 1083 1308 707 41.4670282948348 43.2923490278672 30.5962878104343 16.9563051033751 18.753439041387 11.5785264012673 38.4518883777121 15.7627568486765 1.28653457192351 7.92496195276521e-08 1.23805240260519e-06 UP ENSG00000261326 LINC01355 long intergenic non-protein coding RNA 1355 [Source:HGNC Symbol;Acc:HGNC:50584] - - - - - - 1:23281309-23286752 20 21 49 98 154 121 0.242083764529808 0.231017071923054 0.534740661414845 1.06282190294895 1.52941496217671 1.37261506249307 0.335947165955902 1.32161730920624 -1.97599822207169 7.99794746723694e-08 1.24880085610299e-06 DOWN ENSG00000162704 ARPC5 actin related protein 2/3 complex subunit 5 [Source:HGNC Symbol;Acc:HGNC:708] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0005200|GO:0051716|GO:0042995|GO:0030055|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0044089|GO:0006955|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0048856|GO:0002757|GO:0006935|GO:0045087|GO:0048468|GO:0006810|GO:0051130|GO:0007275|GO:0032535|GO:0005924|GO:0006952|GO:0005912|GO:0031982|GO:0051128|GO:0022607|GO:0005737|GO:0032970|GO:0006928|GO:0032403|GO:0005885|GO:0050776|GO:0007154|GO:0016477|GO:0007165|GO:0050778|GO:0070062|GO:0008092|GO:0030030|GO:0048869|GO:0030029|GO:0031334|GO:0043254|GO:0006996|GO:0016192|GO:0000902|GO:0006909|GO:0005829|GO:0031175|GO:0007166|GO:0032956|GO:0007010|GO:0003779|GO:0000904|GO:0002429|GO:0002764|GO:0006461|GO:0030036|GO:0051015|GO:0035556|GO:0032273|GO:0033043|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0030832|GO:0048858|GO:0005856|GO:0038096|GO:0005925|GO:0010638|GO:0048666|GO:0030182|GO:0015629|GO:0007411|GO:0034622|GO:0030838|GO:0043623|GO:0002768|GO:0008064|GO:0061564|GO:0051493|GO:0007167|GO:0002431|GO:0006897|GO:0022008|GO:0048667|GO:0007264|GO:0007015|GO:0051495|GO:0048812|GO:0030833|GO:0051258|GO:0007409|GO:0048699|GO:0045010|GO:0038093|GO:0007169|GO:0008154|GO:0038094|GO:0048013|GO:0034314|GO:0030041 locomotion|developmental process|macromolecular complex|immune system process|structural molecule activity|signaling|cell|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|structural constituent of cytoskeleton|cellular response to stimulus|cell projection|cell-substrate junction|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|positive regulation of cellular component biogenesis|immune response|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|anatomical structure development|immune response-activating signal transduction|chemotaxis|innate immune response|cell development|transport|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component size|cell-substrate adherens junction|defense response|adherens junction|vesicle|regulation of cellular component organization|cellular component assembly|cytoplasm|regulation of actin filament-based process|movement of cell or subcellular component|protein complex binding|Arp2/3 protein complex|regulation of immune response|cell communication|cell migration|signal transduction|positive regulation of immune response|extracellular exosome|cytoskeletal protein binding|cell projection organization|cellular developmental process|actin filament-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|organelle organization|vesicle-mediated transport|cell morphogenesis|phagocytosis|cytosol|neuron projection development|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|cytoskeleton organization|actin binding|cell morphogenesis involved in differentiation|immune response-activating cell surface receptor signaling pathway|immune response-regulating signaling pathway|protein complex assembly|actin cytoskeleton organization|actin filament binding|intracellular signal transduction|positive regulation of protein polymerization|regulation of organelle organization|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|regulation of actin filament length|cell projection morphogenesis|cytoskeleton|Fc-gamma receptor signaling pathway involved in phagocytosis|focal adhesion|positive regulation of organelle organization|neuron development|neuron differentiation|actin cytoskeleton|axon guidance|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|cellular protein complex assembly|immune response-regulating cell surface receptor signaling pathway|regulation of actin polymerization or depolymerization|axon development|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|Fc receptor mediated stimulatory signaling pathway|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|actin filament organization|positive regulation of cytoskeleton organization|neuron projection morphogenesis|regulation of actin filament polymerization|protein polymerization|axonogenesis|generation of neurons|actin nucleation|Fc receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|Fc-gamma receptor signaling pathway|ephrin receptor signaling pathway|Arp2/3 complex-mediated actin nucleation|actin filament polymerization K05754 actin related protein 2/3 complex, subunit 5[-] hsa04144|hsa04810|hsa04666|hsa05132|hsa05100|hsa05131|hsa05130 Endocytosis - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human) 1:183620846-183635757 3416 3373 3405 2000 1056 1304 16.8929750693683 15.1594899143332 15.1816713375922 8.86167570563915 4.28469820437021 6.04358721700967 15.7447121070979 6.39665370900634 1.29947808960157 8.07520984251103e-08 1.26020551300745e-06 UP ENSG00000165105 RASEF RAS and EF-hand domain containing [Source:HGNC Symbol;Acc:HGNC:26464] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0051641|GO:0016787|GO:0005622|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0043169|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0000166|GO:0046872|GO:0035639|GO:0001883|GO:0015031|GO:0016818|GO:0046907|GO:0032549|GO:0048471|GO:0034613|GO:0035556|GO:0017076|GO:0032561|GO:0051169|GO:0005509|GO:0006886|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0006913|GO:0017111|GO:0003924 signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|cellular localization|hydrolase activity|intracellular|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|cation binding|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|establishment of localization in cell|nucleotide binding|metal ion binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|perinuclear region of cytoplasm|cellular protein localization|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|nuclear transport|calcium ion binding|intracellular protein transport|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|nucleocytoplasmic transport|nucleoside-triphosphatase activity|GTPase activity - - - - 9:82979585-83063177 263 348 543 900 1061 968 2.53423533281263 3.04753863554232 4.71742012415747 7.77017351856557 8.38830173144469 8.74167558032651 3.43306469750414 8.30005027677892 -1.27362302974872 8.07968609618729e-08 1.26024529109496e-06 DOWN ENSG00000140263 SORD sorbitol dehydrogenase [Source:HGNC Symbol;Acc:HGNC:11184] GO:0040011|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042995|GO:0097159|GO:0016491|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0048870|GO:0030246|GO:0043227|GO:0048037|GO:0009605|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0005929|GO:0031090|GO:0042802|GO:0044262|GO:0006082|GO:0009991|GO:0044281|GO:0031982|GO:0019637|GO:0016614|GO:0043231|GO:0031514|GO:0043169|GO:0005737|GO:0030317|GO:0005975|GO:0006928|GO:0031966|GO:0042493|GO:0070062|GO:0009725|GO:0050662|GO:0006970|GO:0000166|GO:0010035|GO:0010033|GO:0055114|GO:0005740|GO:0005829|GO:0046872|GO:0006066|GO:0010038|GO:0044275|GO:0016616|GO:0005996|GO:0046688|GO:0005739|GO:0016052|GO:0006796|GO:1901137|GO:0019640|GO:0031667|GO:0016051|GO:0051287|GO:0006060|GO:0019318|GO:0046686|GO:0046164|GO:0046395|GO:0051164|GO:0046914|GO:0019752|GO:0003939|GO:0046526|GO:0006062|GO:0019319|GO:0051160|GO:0006006|GO:0006000|GO:0032787|GO:0008270|GO:0046370 locomotion|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cell projection|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cell motility|carbohydrate binding|membrane-bounded organelle|cofactor binding|response to external stimulus|biosynthetic process|extracellular space|intracellular|protein binding|cilium|organelle membrane|identical protein binding|cellular carbohydrate metabolic process|organic acid metabolic process|response to extracellular stimulus|small molecule metabolic process|vesicle|organophosphate metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|motile cilium|cation binding|cytoplasm|sperm motility|carbohydrate metabolic process|movement of cell or subcellular component|mitochondrial membrane|response to drug|extracellular exosome|response to hormone|coenzyme binding|response to osmotic stress|nucleotide binding|response to inorganic substance|response to organic substance|oxidation-reduction process|mitochondrial envelope|cytosol|metal ion binding|alcohol metabolic process|response to metal ion|cellular carbohydrate catabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|monosaccharide metabolic process|response to copper ion|mitochondrion|carbohydrate catabolic process|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|glucuronate catabolic process to xylulose 5-phosphate|response to nutrient levels|carbohydrate biosynthetic process|NAD binding|sorbitol metabolic process|hexose metabolic process|response to cadmium ion|alcohol catabolic process|carboxylic acid catabolic process|L-xylitol metabolic process|transition metal ion binding|carboxylic acid metabolic process|L-iditol 2-dehydrogenase activity|D-xylulose reductase activity|sorbitol catabolic process|hexose biosynthetic process|L-xylitol catabolic process|glucose metabolic process|fructose metabolic process|monocarboxylic acid metabolic process|zinc ion binding|fructose biosynthetic process K00008 L-iditol 2-dehydrogenase[1.1.1.14] hsa01100|hsa00040|hsa00051 Metabolic pathways - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Fructose and mannose metabolism - Homo sapiens (human) 15:45023104-45077185 1329 1406 1461 770 820 639 10.6441627321404 10.2341562977585 10.5499657667897 5.52554228190099 5.38850449067557 4.79640852045312 10.4760949322295 5.23681843100989 1.00033854807812 8.10582253000396e-08 1.26366175358088e-06 UP ENSG00000136114 THSD1 thrombospondin type 1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:17754] GO:0005623|GO:0016020|GO:0005576|GO:0031224|GO:0005622|GO:0005737|GO:0016021 cell|membrane|extracellular region|intrinsic component of membrane|intracellular|cytoplasm|integral component of membrane - - - - 13:52377167-52406494 13 17 13 1 1 1 0.182129025312061 0.216461588433759 0.164207031447892 0.0125468000595785 0.0114999460456234 0.0131284898747709 0.187599215064571 0.0123917453266576 3.92020248687425 8.15157457559397e-08 1.27013104060429e-06 UP ENSG00000151491 EPS8 epidermal growth factor receptor pathway substrate 8 [Source:HGNC Symbol;Acc:HGNC:3420] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0060090|GO:0051716|GO:0042995|GO:0048523|GO:0008283|GO:0050794|GO:0060076|GO:0043229|GO:0032420|GO:0050900|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0030427|GO:0043227|GO:0044708|GO:0071944|GO:0031252|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0007626|GO:0048856|GO:0036336|GO:0035591|GO:0005903|GO:0007049|GO:0008360|GO:0008344|GO:0030534|GO:0022402|GO:0005938|GO:0098797|GO:0032421|GO:0032535|GO:0031982|GO:0051128|GO:0030426|GO:0022607|GO:0005887|GO:0070358|GO:0019899|GO:0005737|GO:0032970|GO:0001726|GO:0043235|GO:0006928|GO:0043005|GO:0009966|GO:0030674|GO:0014069|GO:0010646|GO:0031226|GO:1902495|GO:0007154|GO:0016477|GO:0007165|GO:0070062|GO:0008092|GO:0031256|GO:0031253|GO:0048869|GO:0016021|GO:0030029|GO:0009967|GO:0043254|GO:0010033|GO:0006996|GO:0051017|GO:0000902|GO:0031333|GO:0008328|GO:0007166|GO:0032956|GO:1903047|GO:0007010|GO:0003779|GO:0044770|GO:0048149|GO:0000278|GO:0043242|GO:0022604|GO:0034702|GO:0006461|GO:0043244|GO:0030036|GO:0032587|GO:0035556|GO:0033043|GO:0007067|GO:0051020|GO:0030832|GO:0005070|GO:0097305|GO:0043241|GO:0017146|GO:0031532|GO:0034622|GO:0044772|GO:0043623|GO:0008064|GO:0045471|GO:0051494|GO:0051493|GO:0007167|GO:0032272|GO:0031267|GO:1901879|GO:0007264|GO:0007015|GO:0010458|GO:0030833|GO:0051764|GO:0051258|GO:0007265|GO:0017016|GO:0043624|GO:0030837|GO:0030834|GO:0061572|GO:0007169|GO:0008154|GO:0030835|GO:0017048|GO:0016601|GO:0051693|GO:0030042|GO:0030041|GO:0038127|GO:0051261|GO:0007173|GO:0048365|GO:0051016 locomotion|developmental process|macromolecular complex|immune system process|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|binding, bridging|cellular response to stimulus|cell projection|negative regulation of cellular process|cell proliferation|regulation of cellular process|excitatory synapse|intracellular organelle|stereocilium|leukocyte migration|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|site of polarized growth|membrane-bounded organelle|single-organism behavior|cell periphery|cell leading edge|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|locomotory behavior|anatomical structure development|dendritic cell migration|signaling adaptor activity|brush border|cell cycle|regulation of cell shape|adult locomotory behavior|adult behavior|cell cycle process|cell cortex|plasma membrane protein complex|stereocilium bundle|regulation of cellular component size|vesicle|regulation of cellular component organization|growth cone|cellular component assembly|integral component of plasma membrane|actin polymerization-dependent cell motility|enzyme binding|cytoplasm|regulation of actin filament-based process|ruffle|receptor complex|movement of cell or subcellular component|neuron projection|regulation of signal transduction|protein binding, bridging|postsynaptic density|regulation of cell communication|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|cell migration|signal transduction|extracellular exosome|cytoskeletal protein binding|leading edge membrane|cell projection membrane|cellular developmental process|integral component of membrane|actin filament-based process|positive regulation of signal transduction|regulation of protein complex assembly|response to organic substance|organelle organization|actin filament bundle assembly|cell morphogenesis|negative regulation of protein complex assembly|ionotropic glutamate receptor complex|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|mitotic cell cycle process|cytoskeleton organization|actin binding|cell cycle phase transition|behavioral response to ethanol|mitotic cell cycle|negative regulation of protein complex disassembly|regulation of cell morphogenesis|ion channel complex|protein complex assembly|regulation of protein complex disassembly|actin cytoskeleton organization|ruffle membrane|intracellular signal transduction|regulation of organelle organization|mitotic nuclear division|GTPase binding|regulation of actin filament length|SH3/SH2 adaptor activity|response to alcohol|protein complex disassembly|NMDA selective glutamate receptor complex|actin cytoskeleton reorganization|cellular macromolecular complex assembly|mitotic cell cycle phase transition|cellular protein complex assembly|regulation of actin polymerization or depolymerization|response to ethanol|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|negative regulation of protein polymerization|small GTPase binding|regulation of protein depolymerization|small GTPase mediated signal transduction|actin filament organization|exit from mitosis|regulation of actin filament polymerization|actin crosslink formation|protein polymerization|Ras protein signal transduction|Ras GTPase binding|cellular protein complex disassembly|negative regulation of actin filament polymerization|regulation of actin filament depolymerization|actin filament bundle organization|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|Rho GTPase binding|Rac protein signal transduction|actin filament capping|actin filament depolymerization|actin filament polymerization|ERBB signaling pathway|protein depolymerization|epidermal growth factor receptor signaling pathway|Rac GTPase binding|barbed-end actin filament capping - - - - 12:15620158-15882329 1342 1724 2079 3795 4041 3869 8.8876398239878 10.376503181626 12.4137377175311 22.5186990627389 21.9578930136248 24.0138353170419 10.5592935743816 22.8301424644685 -1.11242654187099 8.19157357128678e-08 1.27569763900467e-06 DOWN ENSG00000141556 TBCD tubulin folding cofactor D [Source:HGNC Symbol;Acc:HGNC:11581] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0005911|GO:0016043|GO:0006457|GO:0007155|GO:0071944|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0008047|GO:0005874|GO:0030155|GO:0005912|GO:0051128|GO:0022607|GO:0051087|GO:0005737|GO:0032886|GO:0031589|GO:0007023|GO:0043085|GO:0007162|GO:0006458|GO:0016328|GO:0008092|GO:0050790|GO:0007017|GO:0019538|GO:0043254|GO:0043296|GO:0006996|GO:0015631|GO:0031333|GO:0045216|GO:0005096|GO:0007010|GO:0051345|GO:0070507|GO:0030695|GO:0010812|GO:0034329|GO:0010810|GO:0006461|GO:0033043|GO:0044267|GO:0051084|GO:0005923|GO:0000226|GO:0005856|GO:0048487|GO:0034622|GO:0034332|GO:0031113|GO:0043623|GO:0043087|GO:0031110|GO:0043547|GO:0051494|GO:0051493|GO:0015630|GO:0032272|GO:0031109|GO:0007043|GO:0034333|GO:0070830|GO:0051258|GO:0007021|GO:0043297|GO:0031111|GO:0031115|GO:0046785 cell|membrane|cellular process|metabolic process|cell junction|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cell-cell junction|cellular component organization|protein folding|cell adhesion|cell periphery|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|regulation of metabolic process|enzyme activator activity|microtubule|regulation of cell adhesion|adherens junction|regulation of cellular component organization|cellular component assembly|chaperone binding|cytoplasm|regulation of microtubule-based process|cell-substrate adhesion|post-chaperonin tubulin folding pathway|positive regulation of catalytic activity|negative regulation of cell adhesion|'de novo' protein folding|lateral plasma membrane|cytoskeletal protein binding|regulation of catalytic activity|microtubule-based process|protein metabolic process|regulation of protein complex assembly|apical junction complex|organelle organization|tubulin binding|negative regulation of protein complex assembly|cell-cell junction organization|GTPase activator activity|cytoskeleton organization|positive regulation of hydrolase activity|regulation of microtubule cytoskeleton organization|GTPase regulator activity|negative regulation of cell-substrate adhesion|cell junction assembly|regulation of cell-substrate adhesion|protein complex assembly|regulation of organelle organization|cellular protein metabolic process|'de novo' posttranslational protein folding|bicellular tight junction|microtubule cytoskeleton organization|cytoskeleton|beta-tubulin binding|cellular macromolecular complex assembly|adherens junction organization|regulation of microtubule polymerization|cellular protein complex assembly|regulation of GTPase activity|regulation of microtubule polymerization or depolymerization|positive regulation of GTPase activity|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|microtubule cytoskeleton|negative regulation of protein polymerization|microtubule polymerization or depolymerization|cell-cell junction assembly|adherens junction assembly|bicellular tight junction assembly|protein polymerization|tubulin complex assembly|apical junction assembly|negative regulation of microtubule polymerization or depolymerization|negative regulation of microtubule polymerization|microtubule polymerization - - - - 17:82752064-82945922 647 634 892 1601 1790 1645 2.49927745239744 2.22576509214973 3.10662701601607 5.5411377620794 5.67323654950931 5.9553151701575 2.61055652018775 5.72322982724874 -1.13247214795359 8.25033522888562e-08 1.28417887342623e-06 DOWN ENSG00000010818 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4921] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:1903506|GO:0044212 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding - - - - 6:142751467-142945201 198 242 397 651 766 810 0.9527180513724 1.05826318639105 1.72228096954865 2.80658162747367 3.02409715559935 3.65269188245631 1.2444207357707 3.16112355517644 -1.3449630854964 8.66808780454507e-08 1.34779736102546e-06 DOWN ENSG00000184182 UBE2F ubiquitin conjugating enzyme E2F (putative) [Source:HGNC Symbol;Acc:HGNC:12480] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0006281|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0005737|GO:0006139|GO:0019787|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0004842|GO:0001883|GO:0036211|GO:0032549|GO:0019788|GO:0006259|GO:0006301|GO:0044267|GO:0017076|GO:0005634|GO:0006974|GO:0044389|GO:0031625|GO:0061630|GO:0005524|GO:0030554|GO:0006464|GO:0032446|GO:0016567|GO:0045116|GO:0000209|GO:0070534 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|ligase activity|intracellular|protein binding|transferase activity|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|nucleobase-containing compound metabolic process|ubiquitin-like protein transferase activity|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|ubiquitin-protein transferase activity|purine nucleoside binding|protein modification process|ribonucleoside binding|NEDD8 transferase activity|DNA metabolic process|postreplication repair|cellular protein metabolic process|purine nucleotide binding|nucleus|cellular response to DNA damage stimulus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|ubiquitin protein ligase activity|ATP binding|adenyl nucleotide binding|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination|protein neddylation|protein polyubiquitination|protein K63-linked ubiquitination K10687 ubiquitin-conjugating enzyme E2 F[2.3.2.23] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 2:237966827-238042782 288 261 291 847 851 555 1.66005490403814 1.36726012608336 1.51229730430171 4.37432812817354 4.02464766453923 2.99814559893742 1.5132041114744 3.7990404638834 -1.32802847694297 8.66767164949364e-08 1.34779736102546e-06 DOWN ENSG00000124370 MCEE methylmalonyl-CoA epimerase [Source:HGNC Symbol;Acc:HGNC:16732] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016853|GO:0005622|GO:0005515|GO:0044255|GO:0016854|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0051186|GO:0006139|GO:0055086|GO:0006629|GO:0006790|GO:0055114|GO:0046872|GO:0019693|GO:0016042|GO:0006637|GO:0044242|GO:0006631|GO:0009116|GO:0034440|GO:0004493|GO:0005759|GO:0005739|GO:0006796|GO:0030258|GO:0015936|GO:0009259|GO:0009117|GO:0046395|GO:0046459|GO:0006163|GO:0019752|GO:0009062|GO:0019395|GO:0042278|GO:0006635|GO:0019626|GO:0046491|GO:0032787 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|isomerase activity|intracellular|protein binding|cellular lipid metabolic process|racemase and epimerase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|lipid metabolic process|sulfur compound metabolic process|oxidation-reduction process|metal ion binding|ribose phosphate metabolic process|lipid catabolic process|acyl-CoA metabolic process|cellular lipid catabolic process|fatty acid metabolic process|nucleoside metabolic process|lipid oxidation|methylmalonyl-CoA epimerase activity|mitochondrial matrix|mitochondrion|phosphate-containing compound metabolic process|lipid modification|coenzyme A metabolic process|ribonucleotide metabolic process|nucleotide metabolic process|carboxylic acid catabolic process|short-chain fatty acid metabolic process|purine nucleotide metabolic process|carboxylic acid metabolic process|fatty acid catabolic process|fatty acid oxidation|purine nucleoside metabolic process|fatty acid beta-oxidation|short-chain fatty acid catabolic process|L-methylmalonyl-CoA metabolic process|monocarboxylic acid metabolic process K05606 methylmalonyl-CoA/ethylmalonyl-CoA epimerase[5.1.99.1] hsa01100|hsa01200|hsa00280|hsa00640|hsa00630 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Valine, leucine and isoleucine degradation - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human)|Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) 2:71109684-71130239 31 25 42 97 118 166 0.991786450844172 0.726916769169881 1.21149318657089 2.78051482999584 3.097465701564 4.97731527259577 0.976732135528314 3.61843193471854 -1.88932976493177 8.70779757776261e-08 1.35326699055973e-06 DOWN ENSG00000185436 IFNLR1 interferon, lambda receptor 1 [Source:HGNC Symbol;Acc:HGNC:18584] GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0006955|GO:0038023|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0042127|GO:0045087|GO:0098797|GO:0050688|GO:0006952|GO:0098542|GO:0005887|GO:0004888|GO:0043235|GO:0009615|GO:0031226|GO:0007154|GO:0007165|GO:0008285|GO:0051607|GO:0016021|GO:0010033|GO:0002385|GO:0007166|GO:0004896|GO:0034097|GO:0032002|GO:0034342|GO:0071310|GO:0050691|GO:0019221|GO:0071345 macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|immune response|signaling receptor activity|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|regulation of immune system process|protein binding|plasma membrane|protein complex|regulation of cell proliferation|innate immune response|plasma membrane protein complex|regulation of defense response to virus|defense response|defense response to other organism|integral component of plasma membrane|transmembrane signaling receptor activity|receptor complex|response to virus|intrinsic component of plasma membrane|cell communication|signal transduction|negative regulation of cell proliferation|defense response to virus|integral component of membrane|response to organic substance|mucosal immune response|cell surface receptor signaling pathway|cytokine receptor activity|response to cytokine|interleukin-28 receptor complex|response to type III interferon|cellular response to organic substance|regulation of defense response to virus by host|cytokine-mediated signaling pathway|cellular response to cytokine stimulus K05140 interleukin 28 receptor alpha[-] hsa04060|hsa04630 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human) 1:24154157-24187959 323 334 505 142 187 183 3.39848789794945 3.19380617200791 4.79058186879646 1.33865245859145 1.61432630209881 1.80452815300182 3.79429197958461 1.58583563789736 1.25858744942769 8.74482160940547e-08 1.35831375820599e-06 UP ENSG00000231989 PPP1R2P3 protein phosphatase 1 regulatory inhibitor subunit 2 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:16318] - - - - - - 5:156850563-156851174 130 148 131 58 37 51 15.0257528577694 15.5466024635658 13.6514561966199 6.00647257315739 3.50883901803613 5.52450345550005 14.741270505985 5.01327168223119 1.55603654661132 8.8191336240172e-08 1.36843251149381e-06 UP ENSG00000255717 SNHG1 small nucleolar RNA host gene 1 [Source:HGNC Symbol;Acc:HGNC:32688] - - - - - - 11:62851988-62855914 2964 2881 2951 1737 1521 1210 14.6895551697505 12.9763841002175 13.1860243423458 7.7130844378112 6.1848274049534 5.62011040442418 13.6173212041046 6.50600741572959 1.06559855275039 8.85191005252358e-08 1.37280479328851e-06 UP ENSG00000205583 STAG3L1 stromal antigen 3-like 1 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:33852] - - - - - - 7:75359194-75395383 93 121 121 290 313 306 2.55476486541724 3.02089086455351 2.99685851353951 7.1377887665482 7.05473547642576 7.87804919945484 2.85750474783675 7.35685781414293 -1.36433381316003 9.03124977079838e-08 1.3998906056979e-06 DOWN ENSG00000136068 FLNB filamin B [Source:HGNC Symbol;Acc:HGNC:3755] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0097159|GO:0030055|GO:0050794|GO:0043229|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0042802|GO:0030017|GO:0030018|GO:0005903|GO:0009888|GO:0048468|GO:0005938|GO:0007275|GO:0003676|GO:0048513|GO:0005924|GO:0005912|GO:0031982|GO:0061061|GO:0051651|GO:0005737|GO:0031674|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0008092|GO:0048869|GO:0016021|GO:0030029|GO:0010033|GO:0006996|GO:0000902|GO:0005829|GO:0003723|GO:0007166|GO:0007010|GO:0034097|GO:0002064|GO:0003779|GO:0000904|GO:0032432|GO:0060537|GO:0043292|GO:0007016|GO:0032507|GO:0043588|GO:0030036|GO:0034613|GO:0042641|GO:0060429|GO:0071310|GO:0030154|GO:0007517|GO:0005856|GO:0005925|GO:0015629|GO:0060538|GO:0019221|GO:0030016|GO:0030855|GO:0030216|GO:0008544|GO:0003382|GO:0001725|GO:0071345|GO:0003334|GO:0044822|GO:0014706|GO:0007519|GO:0009913 developmental process|signaling|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|cell-substrate junction|regulation of cellular process|intracellular organelle|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|identical protein binding|sarcomere|Z disc|brush border|tissue development|cell development|cell cortex|multicellular organism development|nucleic acid binding|animal organ development|cell-substrate adherens junction|adherens junction|vesicle|muscle structure development|maintenance of location in cell|cytoplasm|I band|protein localization|cell communication|signal transduction|extracellular exosome|cytoskeletal protein binding|cellular developmental process|integral component of membrane|actin filament-based process|response to organic substance|organelle organization|cell morphogenesis|cytosol|RNA binding|cell surface receptor signaling pathway|cytoskeleton organization|response to cytokine|epithelial cell development|actin binding|cell morphogenesis involved in differentiation|actin filament bundle|muscle tissue development|contractile fiber|cytoskeletal anchoring at plasma membrane|maintenance of protein location in cell|skin development|actin cytoskeleton organization|cellular protein localization|actomyosin|epithelium development|cellular response to organic substance|cell differentiation|muscle organ development|cytoskeleton|focal adhesion|actin cytoskeleton|skeletal muscle organ development|cytokine-mediated signaling pathway|myofibril|epithelial cell differentiation|keratinocyte differentiation|epidermis development|epithelial cell morphogenesis|stress fiber|cellular response to cytokine stimulus|keratinocyte development|poly(A) RNA binding|striated muscle tissue development|skeletal muscle tissue development|epidermal cell differentiation K04437 filamin[-] hsa04010|hsa05205|hsa04510|hsa05132 MAPK signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Salmonella infection - Homo sapiens (human) 3:58008400-58172251 2299 2444 5709 10110 10996 10134 8.90017776359896 8.59885884573079 19.9266338636812 35.0677983810004 34.9270850045013 36.7679554340672 12.4752234910036 35.5876129398563 -1.51230950509945 9.07207585598271e-08 1.40548911574732e-06 DOWN ENSG00000166169 POLL polymerase (DNA directed), lambda [Source:HGNC Symbol;Acc:HGNC:9184] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0016740|GO:0048856|GO:0006281|GO:0016445|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0016772|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0002377|GO:0006139|GO:0002566|GO:0044249|GO:0003677|GO:0034645|GO:0046872|GO:0016446|GO:0006302|GO:0031981|GO:0005654|GO:0006259|GO:0009059|GO:0016779|GO:0006289|GO:0005634|GO:0006974|GO:0006303|GO:0034061|GO:0006260|GO:0071897|GO:0003887 developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|immune system development|protein binding|transferase activity|anatomical structure development|DNA repair|somatic diversification of immunoglobulins|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|immunoglobulin production|nucleobase-containing compound metabolic process|somatic diversification of immune receptors via somatic mutation|cellular biosynthetic process|DNA binding|cellular macromolecule biosynthetic process|metal ion binding|somatic hypermutation of immunoglobulin genes|double-strand break repair|nuclear lumen|nucleoplasm|DNA metabolic process|macromolecule biosynthetic process|nucleotidyltransferase activity|nucleotide-excision repair|nucleus|cellular response to DNA damage stimulus|double-strand break repair via nonhomologous end joining|DNA polymerase activity|DNA replication|DNA biosynthetic process|DNA-directed DNA polymerase activity K03512 DNA polymerase lambda [EC:2.7.7.7 4.2.99.-][-] hsa03410|hsa03450 Base excision repair - Homo sapiens (human)|Non-homologous end-joining - Homo sapiens (human) 10:101578882-101588270 115 111 212 377 429 546 0.765332973398995 0.671363341371209 1.27204941965703 2.24798005034586 2.342494325349 3.40545018800073 0.902915244809078 2.66530818789853 -1.56163988481536 9.14378089488322e-08 1.41586325122325e-06 DOWN ENSG00000000460 C1orf112 chromosome 1 open reading frame 112 [Source:HGNC Symbol;Acc:HGNC:25565] - - - - - - 1:169662007-169854080 179 225 282 685 834 445 1.65449771145788 1.89006577713949 2.35005140789194 5.67286572271145 6.32481485949745 3.85481433174648 1.9648716321631 5.28416497131846 -1.42724044588245 9.21344518662676e-08 1.42582108168845e-06 DOWN ENSG00000068885 IFT80 intraflagellar transport 80 [Source:HGNC Symbol;Acc:HGNC:29262] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0023051|GO:0009653|GO:0016043|GO:0023057|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0042127|GO:0030992|GO:0009888|GO:0007275|GO:0048513|GO:0030990|GO:0022607|GO:0005737|GO:0009887|GO:0009966|GO:0050673|GO:0072372|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0001503|GO:0097542|GO:0060348|GO:0008285|GO:0030030|GO:0048869|GO:0009967|GO:0006996|GO:0030111|GO:0000902|GO:0005813|GO:0048705|GO:0030178|GO:0051216|GO:0007166|GO:0005815|GO:0045880|GO:0008589|GO:0044782|GO:0001649|GO:0030031|GO:0050678|GO:0050680|GO:0070925|GO:0042384|GO:0032990|GO:0060349|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0005856|GO:0060271|GO:0016055|GO:0035058|GO:0002062|GO:0007224|GO:2000051|GO:0015630|GO:0035567 developmental process|macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|regulation of signaling|anatomical structure morphogenesis|cellular component organization|negative regulation of signaling|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of cell proliferation|intraciliary transport particle B|tissue development|multicellular organism development|animal organ development|intraciliary transport particle|cellular component assembly|cytoplasm|organ morphogenesis|regulation of signal transduction|epithelial cell proliferation|primary cilium|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|ossification|ciliary tip|bone development|negative regulation of cell proliferation|cell projection organization|cellular developmental process|positive regulation of signal transduction|organelle organization|regulation of Wnt signaling pathway|cell morphogenesis|centrosome|skeletal system morphogenesis|negative regulation of Wnt signaling pathway|cartilage development|cell surface receptor signaling pathway|microtubule organizing center|positive regulation of smoothened signaling pathway|regulation of smoothened signaling pathway|cilium organization|osteoblast differentiation|cell projection assembly|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|organelle assembly|cilium assembly|cell part morphogenesis|bone morphogenesis|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|cytoskeleton|cilium morphogenesis|Wnt signaling pathway|nonmotile primary cilium assembly|chondrocyte differentiation|smoothened signaling pathway|negative regulation of non-canonical Wnt signaling pathway|microtubule cytoskeleton|non-canonical Wnt signaling pathway - - - - 3:160256986-160399880 297 372 672 1127 1121 1443 1.37438368306712 1.56449936037744 2.80372342141685 4.672760464147 4.25623482340209 6.25816553889935 1.9142021549538 5.06238694214948 -1.40307458573393 9.21764148073526e-08 1.42582108168845e-06 DOWN ENSG00000155287 SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 [Source:HGNC Symbol;Acc:HGNC:23472] GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003735|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0006810|GO:0034641|GO:0044281|GO:0043231|GO:0005737|GO:0042592|GO:0031966|GO:0016021|GO:0044249|GO:0019538|GO:0005740|GO:0034645|GO:0006518|GO:0048878|GO:0006811|GO:0005743|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0043043|GO:0006412|GO:0050801|GO:0055065|GO:0055072 structural molecule activity|cell|membrane|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|transport|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|mitochondrial membrane|integral component of membrane|cellular biosynthetic process|protein metabolic process|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|chemical homeostasis|ion transport|mitochondrial inner membrane|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|peptide biosynthetic process|translation|ion homeostasis|metal ion homeostasis|iron ion homeostasis - - - - 10:99610522-99620609 512 482 481 241 254 222 13.9673122842973 11.9500734482943 11.8304957209222 5.89056709349972 5.68517796299378 5.67576895848973 12.5826271511713 5.75050467166108 1.12967269727696 9.32408084874877e-08 1.44153863106445e-06 UP ENSG00000119899 SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 [Source:HGNC Symbol;Acc:HGNC:10933] GO:0005215|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0030672|GO:0008021|GO:0022857|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0006486|GO:0044255|GO:0006810|GO:0031982|GO:0015136|GO:0005887|GO:0043231|GO:0030133|GO:0005774|GO:0005737|GO:0012506|GO:0005975|GO:0030658|GO:0022891|GO:0031226|GO:0055085|GO:0006629|GO:0016021|GO:0044249|GO:0019538|GO:0006490|GO:0034645|GO:0043412|GO:0006487|GO:0031410|GO:0005773|GO:0016023|GO:0009100|GO:0036211|GO:0070382|GO:0006811|GO:0015075|GO:0051119|GO:0031988|GO:0070085|GO:0030659|GO:1901137|GO:0044267|GO:0009059|GO:1901264|GO:0009101|GO:0006820|GO:0043413|GO:0015711|GO:0000323|GO:0015293|GO:0015992|GO:0008509|GO:0006488|GO:0006812|GO:0018279|GO:0046942|GO:0015739|GO:0046943|GO:0006865|GO:0006464|GO:0005765|GO:0008324|GO:0005764|GO:0005351|GO:0018193|GO:0008514|GO:0043687|GO:0015672|GO:0015295 transporter activity|synapse|cell|membrane|cellular process|metabolic process|cell junction|synaptic vesicle membrane|synaptic vesicle|transmembrane transporter activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|organelle membrane|protein glycosylation|cellular lipid metabolic process|transport|vesicle|sialic acid transmembrane transporter activity|integral component of plasma membrane|intracellular membrane-bounded organelle|transport vesicle|vacuolar membrane|cytoplasm|vesicle membrane|carbohydrate metabolic process|transport vesicle membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|lipid metabolic process|integral component of membrane|cellular biosynthetic process|protein metabolic process|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|macromolecule modification|protein N-linked glycosylation|cytoplasmic vesicle|vacuole|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|protein modification process|exocytic vesicle|ion transport|ion transmembrane transporter activity|sugar transmembrane transporter activity|membrane-bounded vesicle|glycosylation|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|carbohydrate derivative transport|glycoprotein biosynthetic process|anion transport|macromolecule glycosylation|organic anion transport|lytic vacuole|symporter activity|proton transport|anion transmembrane transporter activity|dolichol-linked oligosaccharide biosynthetic process|cation transport|protein N-linked glycosylation via asparagine|carboxylic acid transport|sialic acid transport|carboxylic acid transmembrane transporter activity|amino acid transport|cellular protein modification process|lysosomal membrane|cation transmembrane transporter activity|lysosome|sugar:proton symporter activity|peptidyl-amino acid modification|organic anion transmembrane transporter activity|post-translational protein modification|monovalent inorganic cation transport|solute:proton symporter activity K12301 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5[-] hsa04142 Lysosome - Homo sapiens (human) 6:73593379-73654155 169 200 373 648 671 807 3.16257549108612 3.40144455444812 6.29327494323112 10.8649158435354 10.3025472590632 14.1532528071711 4.28576499625512 11.7735719699232 -1.45792743511635 9.45386411626357e-08 1.46084709796549e-06 DOWN ENSG00000171490 RSL1D1 ribosomal L1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:24534] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0043227|GO:0050793|GO:0005622|GO:0005515|GO:0010941|GO:0003676|GO:0033554|GO:0043231|GO:0032880|GO:0008104|GO:0001503|GO:0008219|GO:0048869|GO:0007568|GO:0005730|GO:2000772|GO:0003723|GO:0001649|GO:0007569|GO:0031981|GO:0012501|GO:0030154|GO:0005634|GO:0090398|GO:0043067|GO:0042981|GO:0044822|GO:0006915 developmental process|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|membrane-bounded organelle|regulation of developmental process|intracellular|protein binding|regulation of cell death|nucleic acid binding|cellular response to stress|intracellular membrane-bounded organelle|regulation of protein localization|protein localization|ossification|cell death|cellular developmental process|aging|nucleolus|regulation of cellular senescence|RNA binding|osteoblast differentiation|cell aging|nuclear lumen|programmed cell death|cell differentiation|nucleus|cellular senescence|regulation of programmed cell death|regulation of apoptotic process|poly(A) RNA binding|apoptotic process - - - - 16:11833850-11851585 8246 5811 7200 3525 3896 2551 65.4800247865591 41.936913965049 51.5480496655835 25.0797004433293 25.3835530761595 18.984751010376 52.9883294723972 23.1493348432883 1.19470390452104 9.50788784609688e-08 1.46843499098487e-06 UP ENSG00000183072 NKX2-5 NK2 homeobox 5 [Source:HGNC Symbol;Acc:HGNC:2488] GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0044089|GO:0071704|GO:0044237|GO:0023051|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0040008|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0007507|GO:0008284|GO:0042127|GO:0045595|GO:0035239|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0060411|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0046620|GO:0043270|GO:0031325|GO:0046483|GO:0051128|GO:1902742|GO:0022607|GO:0035265|GO:0061061|GO:0055017|GO:0045597|GO:0043231|GO:0005737|GO:0000981|GO:0007389|GO:0003012|GO:0001076|GO:0003161|GO:0009887|GO:0005667|GO:0009966|GO:0048729|GO:0046983|GO:0048598|GO:0048568|GO:1903524|GO:0009890|GO:0003682|GO:0060561|GO:0003207|GO:0003166|GO:0060548|GO:0010646|GO:0006139|GO:0007154|GO:0061383|GO:0007165|GO:0003151|GO:0009968|GO:0048638|GO:0003279|GO:0008134|GO:0008219|GO:0048869|GO:0030029|GO:0044249|GO:1903779|GO:0031334|GO:0043254|GO:0010033|GO:0051891|GO:0031324|GO:0031323|GO:0048732|GO:0003013|GO:0006996|GO:0003162|GO:0003205|GO:0000982|GO:0030111|GO:0060043|GO:0003677|GO:0003278|GO:0003143|GO:0010468|GO:0006936|GO:0071773|GO:0034645|GO:0030178|GO:0007166|GO:2000736|GO:0002009|GO:0003208|GO:0044798|GO:0001944|GO:0007010|GO:0030097|GO:0072358|GO:0001104|GO:0003148|GO:0060347|GO:0061337|GO:0010629|GO:0010623|GO:0010720|GO:0042692|GO:0043069|GO:0046982|GO:0051252|GO:0048536|GO:0035050|GO:0035051|GO:0048738|GO:2000144|GO:0003007|GO:0045823|GO:0060420|GO:0055006|GO:0009790|GO:0090257|GO:0010628|GO:0030878|GO:0051147|GO:0003165|GO:0060412|GO:0060537|GO:0060037|GO:0003705|GO:0006811|GO:0060413|GO:0003002|GO:0060485|GO:0035270|GO:0050769|GO:0003231|GO:0001570|GO:0070848|GO:0061371|GO:0003209|GO:0006461|GO:0055001|GO:0030036|GO:0003283|GO:0043269|GO:0060038|GO:2000142|GO:0070925|GO:0012501|GO:0060429|GO:0010467|GO:0010765|GO:0048562|GO:0060841|GO:0007399|GO:0060562|GO:0071310|GO:0007512|GO:0060415|GO:0031328|GO:0009059|GO:0003211|GO:0030154|GO:0003281|GO:0030239|GO:0001228|GO:0007517|GO:0001191|GO:0016070|GO:0072359|GO:0008015|GO:0010557|GO:0005634|GO:0042803|GO:0051148|GO:0043067|GO:0061384|GO:0051960|GO:0045165|GO:2000738|GO:0048644|GO:0016202|GO:0006941|GO:0030182|GO:0008016|GO:0055002|GO:0060971|GO:0016055|GO:0000975|GO:0055024|GO:0051153|GO:0045893|GO:0003168|GO:0048863|GO:0055003|GO:0009792|GO:0090090|GO:0051154|GO:0006937|GO:0060828|GO:0045892|GO:0060261|GO:0055013|GO:0032774|GO:0043565|GO:0060047|GO:0006812|GO:2001141|GO:0003342|GO:0001077|GO:0071363|GO:1902679|GO:0042693|GO:0003690|GO:0003285|GO:0003350|GO:0001947|GO:0030509|GO:0007167|GO:0009855|GO:0003222|GO:0060929|GO:0060928|GO:0051146|GO:0042981|GO:0003215|GO:0003229|GO:0043066|GO:0060972|GO:0090575|GO:0031032|GO:0055008|GO:0014706|GO:0022008|GO:0055007|GO:0055010|GO:0045214|GO:0050767|GO:0006351|GO:0010002|GO:0006915|GO:0006355|GO:0045666|GO:0045944|GO:0006366|GO:1903507|GO:0006352|GO:0006357|GO:0055005|GO:0048699|GO:0007368|GO:0010832|GO:1903506|GO:0044212|GO:0006942|GO:0060070|GO:0060048|GO:0055014|GO:0055015|GO:0001190|GO:0060923|GO:0003221|GO:0014902|GO:0055117|GO:0002028|GO:0043009|GO:0030001|GO:0010830|GO:0010657|GO:0055012|GO:0007178|GO:0000122|GO:0010656|GO:0045664|GO:0015672|GO:0006367|GO:0010735|GO:0010664|GO:0006814|GO:0000976|GO:0001012|GO:0010736|GO:0001159|GO:0000977|GO:0010659|GO:0000987|GO:0010667|GO:0000978 developmental process|growth|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|positive regulation of cellular component biogenesis|organic substance metabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|regulation of cell proliferation|regulation of cell differentiation|tube morphogenesis|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|transport|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|cardiac septum morphogenesis|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|regulation of organ growth|positive regulation of ion transport|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|apoptotic process involved in development|cellular component assembly|organ growth|muscle structure development|cardiac muscle tissue growth|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|muscle system process|transcription factor activity, RNA polymerase II transcription factor binding|cardiac conduction system development|organ morphogenesis|transcription factor complex|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|embryonic organ development|positive regulation of blood circulation|negative regulation of biosynthetic process|chromatin binding|apoptotic process involved in morphogenesis|cardiac chamber formation|bundle of His development|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|trabecula morphogenesis|signal transduction|outflow tract morphogenesis|negative regulation of signal transduction|regulation of developmental growth|cardiac septum development|transcription factor binding|cell death|cellular developmental process|actin filament-based process|cellular biosynthetic process|regulation of cardiac conduction|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|positive regulation of cardioblast differentiation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|circulatory system process|organelle organization|atrioventricular node development|cardiac chamber development|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of Wnt signaling pathway|regulation of cardiac muscle cell proliferation|DNA binding|apoptotic process involved in heart morphogenesis|embryonic heart tube morphogenesis|regulation of gene expression|muscle contraction|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|regulation of stem cell differentiation|morphogenesis of an epithelium|cardiac ventricle morphogenesis|nuclear transcription factor complex|vasculature development|cytoskeleton organization|hemopoiesis|cardiovascular system development|RNA polymerase II transcription cofactor activity|outflow tract septum morphogenesis|heart trabecula formation|cardiac conduction|negative regulation of gene expression|developmental programmed cell death|positive regulation of cell development|muscle cell differentiation|negative regulation of programmed cell death|protein heterodimerization activity|regulation of RNA metabolic process|spleen development|embryonic heart tube development|cardiocyte differentiation|cardiac muscle tissue development|positive regulation of DNA-templated transcription, initiation|heart morphogenesis|positive regulation of heart contraction|regulation of heart growth|cardiac cell development|embryo development|regulation of muscle system process|positive regulation of gene expression|thyroid gland development|regulation of muscle cell differentiation|Purkinje myocyte development|ventricular septum morphogenesis|muscle tissue development|pharyngeal system development|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|ion transport|atrial septum morphogenesis|regionalization|mesenchyme development|endocrine system development|positive regulation of neurogenesis|cardiac ventricle development|vasculogenesis|response to growth factor|determination of heart left/right asymmetry|cardiac atrium morphogenesis|protein complex assembly|muscle cell development|actin cytoskeleton organization|atrial septum development|regulation of ion transport|cardiac muscle cell proliferation|regulation of DNA-templated transcription, initiation|organelle assembly|programmed cell death|epithelium development|gene expression|positive regulation of sodium ion transport|embryonic organ morphogenesis|venous blood vessel development|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|adult heart development|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cardiac ventricle formation|cell differentiation|ventricular septum development|myofibril assembly|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|muscle organ development|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|circulatory system development|blood circulation|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|negative regulation of muscle cell differentiation|regulation of programmed cell death|heart trabecula morphogenesis|regulation of nervous system development|cell fate commitment|positive regulation of stem cell differentiation|muscle organ morphogenesis|regulation of striated muscle tissue development|striated muscle contraction|neuron differentiation|regulation of heart contraction|striated muscle cell development|embryonic heart tube left/right pattern formation|Wnt signaling pathway|regulatory region DNA binding|regulation of cardiac muscle tissue development|regulation of striated muscle cell differentiation|positive regulation of transcription, DNA-templated|Purkinje myocyte differentiation|stem cell differentiation|cardiac myofibril assembly|embryo development ending in birth or egg hatching|negative regulation of canonical Wnt signaling pathway|negative regulation of striated muscle cell differentiation|regulation of muscle contraction|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|positive regulation of transcription initiation from RNA polymerase II promoter|cardiac muscle cell development|RNA biosynthetic process|sequence-specific DNA binding|heart contraction|cation transport|regulation of RNA biosynthetic process|proepicardium development|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cellular response to growth factor stimulus|negative regulation of RNA biosynthetic process|muscle cell fate commitment|double-stranded DNA binding|septum secundum development|pulmonary myocardium development|heart looping|BMP signaling pathway|enzyme linked receptor protein signaling pathway|determination of bilateral symmetry|ventricular trabecula myocardium morphogenesis|atrioventricular node cell fate commitment|atrioventricular node cell development|striated muscle cell differentiation|regulation of apoptotic process|cardiac right ventricle morphogenesis|ventricular cardiac muscle tissue development|negative regulation of apoptotic process|left/right pattern formation|RNA polymerase II transcription factor complex|actomyosin structure organization|cardiac muscle tissue morphogenesis|striated muscle tissue development|neurogenesis|cardiac muscle cell differentiation|ventricular cardiac muscle tissue morphogenesis|sarcomere organization|regulation of neurogenesis|transcription, DNA-templated|cardioblast differentiation|apoptotic process|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|ventricular cardiac myofibril assembly|generation of neurons|determination of left/right symmetry|negative regulation of myotube differentiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of striated muscle contraction|canonical Wnt signaling pathway|cardiac muscle contraction|atrial cardiac muscle cell development|ventricular cardiac muscle cell development|transcriptional activator activity, RNA polymerase II transcription factor binding|cardiac muscle cell fate commitment|right ventricular cardiac muscle tissue morphogenesis|myotube differentiation|regulation of cardiac muscle contraction|regulation of sodium ion transport|chordate embryonic development|metal ion transport|regulation of myotube differentiation|muscle cell apoptotic process|ventricular cardiac muscle cell differentiation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative regulation of muscle cell apoptotic process|regulation of neuron differentiation|monovalent inorganic cation transport|transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|negative regulation of striated muscle cell apoptotic process|sodium ion transport|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|serum response element binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|cardiac muscle cell apoptotic process|core promoter proximal region sequence-specific DNA binding|negative regulation of cardiac muscle cell apoptotic process|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 5:173232109-173235357 242 264 211 87 121 73 3.7914324174624 3.75899174947383 2.98046552721174 1.22125667359125 1.55539938594953 1.07187022443567 3.51029656471599 1.28284209465882 1.45224932098677 9.59810713304738e-08 1.48160232859357e-06 UP ENSG00000179314 WSCD1 WSC domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29060] GO:0016020|GO:0008152|GO:0003824|GO:0031224|GO:0016740|GO:0016021|GO:0008146 membrane|metabolic process|catalytic activity|intrinsic component of membrane|transferase activity|integral component of membrane|sulfotransferase activity - - - - 17:5772234-6124427 311 352 566 1010 1247 860 1.19541189597279 1.22964355441137 1.96149774238915 3.47837206508143 3.9327052932653 3.09802389465731 1.4621843975911 3.50303375100135 -1.26047962574175 9.67778601856519e-08 1.49312983875062e-06 DOWN ENSG00000138658 ZGRF1 zinc finger, GRF-type containing 1 [Source:HGNC Symbol;Acc:HGNC:25654] GO:0016020|GO:0005488|GO:0043167|GO:0031224|GO:0043169|GO:0016021|GO:0046872|GO:0046914|GO:0008270 membrane|binding|ion binding|intrinsic component of membrane|cation binding|integral component of membrane|metal ion binding|transition metal ion binding|zinc ion binding - - - - 4:112539333-112636995 41 81 100 263 240 231 0.231113374232768 0.41495751797454 0.50822150792604 1.32828267039566 1.10998391276631 1.22032920029594 0.384764133377783 1.2195319278193 -1.66428130240004 9.71479638039108e-08 1.49806576002167e-06 DOWN ENSG00000176399 DMRTA1 DMRT-like family A1 [Source:HGNC Symbol;Acc:HGNC:13826] GO:0032502|GO:0000003|GO:0007610|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0042698|GO:0019953|GO:0044237|GO:0003006|GO:0043227|GO:0032504|GO:0009058|GO:0005622|GO:0022602|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0042802|GO:0045137|GO:0007618|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0048608|GO:0001541|GO:0043169|GO:0046983|GO:0007548|GO:0006139|GO:0008406|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0008585|GO:0061458|GO:0051252|GO:0046545|GO:0007617|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0042803|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0060179|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001159|GO:0000987 developmental process|reproduction|behavior|cell|rhythmic process|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|ovulation cycle|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|intracellular|ovulation cycle process|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|identical protein binding|development of primary sexual characteristics|mating|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|reproductive structure development|ovarian follicle development|cation binding|protein dimerization activity|sex differentiation|nucleobase-containing compound metabolic process|gonad development|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|female gonad development|reproductive system development|regulation of RNA metabolic process|development of primary female sexual characteristics|mating behavior|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|protein homodimerization activity|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|male mating behavior|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|core promoter proximal region DNA binding|core promoter proximal region sequence-specific DNA binding - - - - 9:22446841-22455740 116 114 117 47 45 43 1.47342267331308 1.31599074106912 1.33989319675546 0.534890266691177 0.468978440593666 0.511876393426807 1.37643553704589 0.505248366903883 1.44587238685944 9.72692611312799e-08 1.49916185948024e-06 UP ENSG00000169756 LIMS1 LIM and senescent cell antigen-like domains 1 [Source:HGNC Symbol;Acc:HGNC:6616] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0030055|GO:0048523|GO:0050794|GO:0006807|GO:0044089|GO:0071704|GO:0043167|GO:0044237|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:0048468|GO:0051130|GO:1901360|GO:0034446|GO:0034641|GO:0005924|GO:0030155|GO:0005912|GO:1901890|GO:0046483|GO:0051128|GO:0022607|GO:0045597|GO:0043169|GO:0019899|GO:0005737|GO:0071559|GO:1901888|GO:0031589|GO:0045184|GO:0009890|GO:0006139|GO:0043085|GO:0008104|GO:0045785|GO:0050790|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0007568|GO:0000902|GO:0005829|GO:0010468|GO:0034645|GO:0045216|GO:0046872|GO:1900026|GO:0051345|GO:0010629|GO:0010720|GO:0051252|GO:0000904|GO:0010628|GO:0071560|GO:0007160|GO:0034329|GO:0007569|GO:0010810|GO:0048471|GO:0070848|GO:0022604|GO:0019900|GO:0010467|GO:1900024|GO:1903393|GO:0071310|GO:0051894|GO:0010770|GO:0009059|GO:0010811|GO:0030154|GO:0016070|GO:0005925|GO:0010769|GO:0045892|GO:0034332|GO:0032774|GO:2001141|GO:0071363|GO:0043087|GO:1902679|GO:0043547|GO:0001952|GO:0007044|GO:0001954|GO:0048041|GO:0046914|GO:0019901|GO:0051893|GO:0006351|GO:0006355|GO:0034333|GO:1903507|GO:1903506|GO:0008270 developmental process|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|cellular metabolic process|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|positive regulation of cellular component organization|organic cyclic compound metabolic process|substrate adhesion-dependent cell spreading|cellular nitrogen compound metabolic process|cell-substrate adherens junction|regulation of cell adhesion|adherens junction|positive regulation of cell junction assembly|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of cell differentiation|cation binding|enzyme binding|cytoplasm|response to transforming growth factor beta|regulation of cell junction assembly|cell-substrate adhesion|establishment of protein localization|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|positive regulation of cell adhesion|regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|aging|cell morphogenesis|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|cell-cell junction organization|metal ion binding|positive regulation of substrate adhesion-dependent cell spreading|positive regulation of hydrolase activity|negative regulation of gene expression|positive regulation of cell development|regulation of RNA metabolic process|cell morphogenesis involved in differentiation|positive regulation of gene expression|cellular response to transforming growth factor beta stimulus|cell-matrix adhesion|cell junction assembly|cell aging|regulation of cell-substrate adhesion|perinuclear region of cytoplasm|response to growth factor|regulation of cell morphogenesis|kinase binding|gene expression|regulation of substrate adhesion-dependent cell spreading|positive regulation of adherens junction organization|cellular response to organic substance|positive regulation of focal adhesion assembly|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|positive regulation of cell-substrate adhesion|cell differentiation|RNA metabolic process|focal adhesion|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|adherens junction organization|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|regulation of GTPase activity|negative regulation of RNA biosynthetic process|positive regulation of GTPase activity|regulation of cell-matrix adhesion|cell-substrate junction assembly|positive regulation of cell-matrix adhesion|focal adhesion assembly|transition metal ion binding|protein kinase binding|regulation of focal adhesion assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|adherens junction assembly|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 2:108534355-108687246 274 398 552 968 1009 1051 1.36540499479266 1.80249433439841 2.48006694084069 4.3219875689067 4.12543246536285 4.90842285798038 1.88265542334392 4.45194763074998 -1.24166764997833 9.73670239920705e-08 1.49989429012346e-06 DOWN ENSG00000129128 SPCS3 signal peptidase complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:26212] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0043234|GO:0012505|GO:0031090|GO:0060341|GO:0006810|GO:0034641|GO:0032940|GO:0043231|GO:0008233|GO:0005737|GO:0007267|GO:0032880|GO:0045184|GO:0046883|GO:0005787|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0005783|GO:0051649|GO:0010817|GO:0016021|GO:0044249|GO:0019538|GO:0034645|GO:0090150|GO:0006518|GO:0090276|GO:0072594|GO:0045047|GO:0051223|GO:0051604|GO:0015031|GO:0070201|GO:0046907|GO:0042886|GO:0051046|GO:0072657|GO:1990234|GO:0009914|GO:0009306|GO:0006508|GO:0034613|GO:0043603|GO:0044267|GO:0010467|GO:0046903|GO:0009059|GO:0050796|GO:0002790|GO:0030073|GO:0043043|GO:0006614|GO:0033365|GO:0016485|GO:0050708|GO:0015833|GO:0006605|GO:0006412|GO:0006886|GO:0006465|GO:0006612|GO:0046879|GO:0072599|GO:0070972|GO:0006613|GO:0030072 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|catalytic activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein complex|endomembrane system|organelle membrane|regulation of cellular localization|transport|cellular nitrogen compound metabolic process|secretion by cell|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|cell-cell signaling|regulation of protein localization|establishment of protein localization|regulation of hormone secretion|signal peptidase complex|regulation of cell communication|protein localization|cell communication|membrane organization|endoplasmic reticulum|establishment of localization in cell|regulation of hormone levels|integral component of membrane|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|peptide metabolic process|regulation of peptide hormone secretion|establishment of protein localization to organelle|protein targeting to ER|regulation of protein transport|protein maturation|protein transport|regulation of establishment of protein localization|intracellular transport|amide transport|regulation of secretion|protein localization to membrane|transferase complex|hormone transport|protein secretion|proteolysis|cellular protein localization|cellular amide metabolic process|cellular protein metabolic process|gene expression|secretion|macromolecule biosynthetic process|regulation of insulin secretion|peptide secretion|insulin secretion|peptide biosynthetic process|SRP-dependent cotranslational protein targeting to membrane|protein localization to organelle|protein processing|regulation of protein secretion|peptide transport|protein targeting|translation|intracellular protein transport|signal peptide processing|protein targeting to membrane|hormone secretion|establishment of protein localization to endoplasmic reticulum|protein localization to endoplasmic reticulum|cotranslational protein targeting to membrane|peptide hormone secretion K12948 signal peptidase complex subunit 3 [EC:3.4.-.-][-] hsa03060 Protein export - Homo sapiens (human) 4:176319964-176332245 832 864 1383 2726 2296 2480 7.40382954733654 6.98758206637713 11.0960803992013 21.7348558873991 16.7638231725034 20.6830179827159 8.49583067097166 19.7272323475395 -1.21536164844638 9.74910063981031e-08 1.50102965704434e-06 DOWN ENSG00000105327 BBC3 BCL2 binding component 3 [Source:HGNC Symbol;Acc:HGNC:17868] GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0044089|GO:0071704|GO:0009628|GO:0044237|GO:0051641|GO:0023051|GO:0045926|GO:0016043|GO:0043227|GO:0019867|GO:0040008|GO:0009893|GO:0005622|GO:1903829|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0060341|GO:0051282|GO:0006810|GO:0051130|GO:0010941|GO:0007275|GO:0097194|GO:0031325|GO:0051128|GO:0033554|GO:0022607|GO:0010942|GO:0043231|GO:0019899|GO:0005737|GO:0032880|GO:0042592|GO:0009966|GO:0031966|GO:0045184|GO:0019725|GO:0032388|GO:0010646|GO:0008340|GO:0043085|GO:0008104|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0005783|GO:0090559|GO:0051649|GO:2000021|GO:0008219|GO:0001666|GO:0050790|GO:0051204|GO:0051238|GO:0001948|GO:0009967|GO:0019538|GO:0031334|GO:0043254|GO:0010033|GO:0031323|GO:0006996|GO:0007568|GO:1902533|GO:2001235|GO:0032268|GO:0005740|GO:0005829|GO:0090150|GO:0030968|GO:0072594|GO:0051345|GO:0007005|GO:0005741|GO:0048878|GO:0032386|GO:0051117|GO:1901216|GO:0070997|GO:0051604|GO:0032461|GO:0005773|GO:1900101|GO:0051208|GO:0046902|GO:0071456|GO:0070201|GO:0046907|GO:0001844|GO:0006811|GO:1902235|GO:0051209|GO:0055082|GO:0010259|GO:0032459|GO:0006986|GO:0072657|GO:0051205|GO:1900740|GO:0051247|GO:0006508|GO:0005739|GO:0006461|GO:1901214|GO:0071453|GO:0034613|GO:0032270|GO:0012501|GO:1901030|GO:0035556|GO:0033043|GO:0044267|GO:0010467|GO:0071310|GO:0051246|GO:0043068|GO:0035967|GO:1903827|GO:1902531|GO:0034976|GO:0043067|GO:0006974|GO:1900103|GO:0097190|GO:0007006|GO:0034220|GO:0010638|GO:0034620|GO:0070059|GO:1901028|GO:0097193|GO:0098655|GO:2001242|GO:0033365|GO:0043065|GO:2001244|GO:0051259|GO:0036498|GO:0000323|GO:0016485|GO:0043523|GO:0006839|GO:0030162|GO:0006812|GO:0032464|GO:0008637|GO:0045862|GO:0043525|GO:0072655|GO:1902237|GO:0052547|GO:0060402|GO:0010822|GO:1903894|GO:0097345|GO:0090200|GO:1902108|GO:0035794|GO:0010821|GO:0001836|GO:1903896|GO:0042981|GO:0050801|GO:0051402|GO:0010952|GO:0006915|GO:0006873|GO:0036294|GO:2000108|GO:0010950|GO:0005764|GO:0043281|GO:1902110|GO:0031638|GO:0030001|GO:0043280|GO:0006919|GO:0051260|GO:0030003|GO:0070585|GO:0052548|GO:0070588|GO:0070230|GO:2001056|GO:0055065|GO:0097553|GO:0006875|GO:2000116|GO:0097202|GO:0070228|GO:0070231|GO:0070234|GO:0006874|GO:0006816|GO:0055074|GO:0070232|GO:0070242|GO:0051480|GO:0070243|GO:0032469|GO:0070509|GO:0060401|GO:0070245|GO:0032471|GO:0007204 developmental process|growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of signaling|negative regulation of growth|cellular component organization|membrane-bounded organelle|outer membrane|regulation of growth|positive regulation of metabolic process|intracellular|positive regulation of cellular protein localization|protein binding|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cellular localization|regulation of sequestering of calcium ion|transport|positive regulation of cellular component organization|regulation of cell death|multicellular organism development|execution phase of apoptosis|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|positive regulation of cell death|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of protein localization|homeostatic process|regulation of signal transduction|mitochondrial membrane|establishment of protein localization|cellular homeostasis|positive regulation of intracellular transport|regulation of cell communication|determination of adult lifespan|positive regulation of catalytic activity|protein localization|cell communication|transmembrane transport|membrane organization|signal transduction|endoplasmic reticulum|regulation of membrane permeability|establishment of localization in cell|regulation of ion homeostasis|cell death|response to hypoxia|regulation of catalytic activity|protein insertion into mitochondrial membrane|sequestering of metal ion|glycoprotein binding|positive regulation of signal transduction|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|regulation of cellular metabolic process|organelle organization|aging|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|mitochondrial envelope|cytosol|establishment of protein localization to membrane|endoplasmic reticulum unfolded protein response|establishment of protein localization to organelle|positive regulation of hydrolase activity|mitochondrion organization|mitochondrial outer membrane|chemical homeostasis|regulation of intracellular transport|ATPase binding|positive regulation of neuron death|neuron death|protein maturation|positive regulation of protein oligomerization|vacuole|regulation of endoplasmic reticulum unfolded protein response|sequestering of calcium ion|regulation of mitochondrial membrane permeability|cellular response to hypoxia|regulation of establishment of protein localization|intracellular transport|protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|ion transport|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|multicellular organism aging|regulation of protein oligomerization|response to unfolded protein|protein localization to membrane|protein insertion into membrane|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|positive regulation of protein metabolic process|proteolysis|mitochondrion|protein complex assembly|regulation of neuron death|cellular response to oxygen levels|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|gene expression|cellular response to organic substance|regulation of protein metabolic process|positive regulation of programmed cell death|cellular response to topologically incorrect protein|regulation of cellular protein localization|regulation of intracellular signal transduction|response to endoplasmic reticulum stress|regulation of programmed cell death|cellular response to DNA damage stimulus|positive regulation of endoplasmic reticulum unfolded protein response|apoptotic signaling pathway|mitochondrial membrane organization|ion transmembrane transport|positive regulation of organelle organization|cellular response to unfolded protein|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|intrinsic apoptotic signaling pathway|cation transmembrane transport|regulation of intrinsic apoptotic signaling pathway|protein localization to organelle|positive regulation of apoptotic process|positive regulation of intrinsic apoptotic signaling pathway|protein oligomerization|IRE1-mediated unfolded protein response|lytic vacuole|protein processing|regulation of neuron apoptotic process|mitochondrial transport|regulation of proteolysis|cation transport|positive regulation of protein homooligomerization|apoptotic mitochondrial changes|positive regulation of proteolysis|positive regulation of neuron apoptotic process|establishment of protein localization to mitochondrion|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|regulation of peptidase activity|calcium ion transport into cytosol|positive regulation of mitochondrion organization|regulation of IRE1-mediated unfolded protein response|mitochondrial outer membrane permeabilization|positive regulation of release of cytochrome c from mitochondria|regulation of mitochondrial membrane permeability involved in apoptotic process|positive regulation of mitochondrial membrane permeability|regulation of mitochondrion organization|release of cytochrome c from mitochondria|positive regulation of IRE1-mediated unfolded protein response|regulation of apoptotic process|ion homeostasis|neuron apoptotic process|positive regulation of peptidase activity|apoptotic process|cellular ion homeostasis|cellular response to decreased oxygen levels|positive regulation of leukocyte apoptotic process|positive regulation of endopeptidase activity|lysosome|regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of mitochondrial membrane permeability involved in apoptotic process|zymogen activation|metal ion transport|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|protein homooligomerization|cellular cation homeostasis|protein localization to mitochondrion|regulation of endopeptidase activity|calcium ion transmembrane transport|positive regulation of lymphocyte apoptotic process|positive regulation of cysteine-type endopeptidase activity|metal ion homeostasis|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|regulation of lymphocyte apoptotic process|T cell apoptotic process|positive regulation of T cell apoptotic process|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of T cell apoptotic process|thymocyte apoptotic process|regulation of cytosolic calcium ion concentration|regulation of thymocyte apoptotic process|endoplasmic reticulum calcium ion homeostasis|calcium ion import|cytosolic calcium ion transport|positive regulation of thymocyte apoptotic process|negative regulation of endoplasmic reticulum calcium ion concentration|positive regulation of cytosolic calcium ion concentration K10132 BCL2-binding component 3[-] hsa05016|hsa04390|hsa04210|hsa05162|hsa04115 Huntington,s disease - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Measles - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 19:47220822-47232766 437 550 570 224 250 285 5.30041008551945 6.06277040343003 6.23329135136735 2.434304210639 2.48791663072759 3.23968364234625 5.86549061343894 2.72063482790428 1.10830845961686 9.81327118454822e-08 1.51013091723455e-06 UP ENSG00000158623 COPG2 coatomer protein complex subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:2237] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0043234|GO:0012505|GO:0031090|GO:0006810|GO:0030660|GO:0031982|GO:0030117|GO:0043231|GO:0005737|GO:0012506|GO:0045184|GO:0008104|GO:0051649|GO:0005794|GO:0030663|GO:0016192|GO:0005829|GO:0005798|GO:0031410|GO:0015031|GO:0030126|GO:0016023|GO:0046907|GO:0031988|GO:0034613|GO:0030659|GO:0000139|GO:0030120|GO:0048193|GO:0006886|GO:0030135|GO:0030137|GO:0006890|GO:0006891 macromolecular complex|structural molecule activity|cell|membrane|binding|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein complex|endomembrane system|organelle membrane|transport|Golgi-associated vesicle membrane|vesicle|membrane coat|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|establishment of protein localization|protein localization|establishment of localization in cell|Golgi apparatus|COPI-coated vesicle membrane|vesicle-mediated transport|cytosol|Golgi-associated vesicle|cytoplasmic vesicle|protein transport|COPI vesicle coat|cytoplasmic, membrane-bounded vesicle|intracellular transport|membrane-bounded vesicle|cellular protein localization|cytoplasmic vesicle membrane|Golgi membrane|vesicle coat|Golgi vesicle transport|intracellular protein transport|coated vesicle|COPI-coated vesicle|retrograde vesicle-mediated transport, Golgi to ER|intra-Golgi vesicle-mediated transport - - - - 7:130506238-130668748 185 200 258 503 519 626 2.67450206916515 2.62772540686979 3.36283198958301 6.51533024948684 6.15609972084976 8.48152357367285 2.88835315520598 7.05098451466982 -1.28757756269192 9.89552725711029e-08 1.52200448600603e-06 DOWN ENSG00000164949 GEM GTP binding protein overexpressed in skeletal muscle [Source:HGNC Symbol;Acc:HGNC:4234] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0030496|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0006955|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0007049|GO:0009898|GO:0051640|GO:0006810|GO:0022402|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0043169|GO:0051656|GO:0098562|GO:0045184|GO:0008104|GO:0005516|GO:0007154|GO:0007165|GO:0051649|GO:0007059|GO:0000166|GO:0006996|GO:0051276|GO:0046872|GO:0007166|GO:0035639|GO:1903047|GO:0001883|GO:0015031|GO:0016818|GO:0000278|GO:0051233|GO:0032549|GO:0035556|GO:0007067|GO:0017076|GO:0019003|GO:0005856|GO:0005634|GO:0005819|GO:0051303|GO:0032561|GO:0072686|GO:0000287|GO:0015630|GO:0051310|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0017111|GO:0003924 immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|small molecule binding|midbody|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|immune response|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|cell cycle|cytoplasmic side of plasma membrane|organelle localization|transport|cell cycle process|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|establishment of organelle localization|cytoplasmic side of membrane|establishment of protein localization|protein localization|calmodulin binding|cell communication|signal transduction|establishment of localization in cell|chromosome segregation|nucleotide binding|organelle organization|chromosome organization|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|mitotic cell cycle process|purine nucleoside binding|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|spindle midzone|ribonucleoside binding|intracellular signal transduction|mitotic nuclear division|purine nucleotide binding|GDP binding|cytoskeleton|nucleus|spindle|establishment of chromosome localization|guanyl ribonucleotide binding|mitotic spindle|magnesium ion binding|microtubule cytoskeleton|metaphase plate congression|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|GTPase activity - - - - 8:94249253-94262350 166 175 322 70 74 92 2.08566634759975 1.99827855923535 3.64760191049944 0.788016242638426 0.762845285626326 1.08331514369529 2.57718227244485 0.878058890653347 1.55340496766876 1.01243705664311e-07 1.5564004062319e-06 UP ENSG00000164038 SLC9B2 solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 [Source:HGNC Symbol;Acc:HGNC:25143] GO:0032502|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0022857|GO:0016491|GO:0050794|GO:0043229|GO:0043227|GO:0031224|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0048856|GO:0031090|GO:1903706|GO:0045595|GO:0019866|GO:0048468|GO:0006810|GO:1903012|GO:0007275|GO:0048513|GO:0045597|GO:0043231|GO:0005737|GO:0031966|GO:0022891|GO:0055085|GO:0060348|GO:0048869|GO:0016021|GO:0055114|GO:0005740|GO:2001206|GO:0030097|GO:0010720|GO:0006811|GO:0015075|GO:1903010|GO:0005743|GO:0005739|GO:0045639|GO:0030154|GO:0001501|GO:0045637|GO:0034220|GO:0002521|GO:0002761|GO:0098655|GO:2001204|GO:0015992|GO:0015297|GO:0006812|GO:0036035|GO:0002763|GO:0030099|GO:0008324|GO:0002573|GO:0045672|GO:1902600|GO:0022890|GO:0030001|GO:0045670|GO:0015672|GO:0006814|GO:0030316|GO:0015299|GO:0015077|GO:0015078 developmental process|transporter activity|immune system process|cell|membrane|cellular process|metabolic process|catalytic activity|transmembrane transporter activity|oxidoreductase activity|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|anatomical structure development|organelle membrane|regulation of hemopoiesis|regulation of cell differentiation|organelle inner membrane|cell development|transport|positive regulation of bone development|multicellular organism development|animal organ development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|substrate-specific transmembrane transporter activity|transmembrane transport|bone development|cellular developmental process|integral component of membrane|oxidation-reduction process|mitochondrial envelope|positive regulation of osteoclast development|hemopoiesis|positive regulation of cell development|ion transport|ion transmembrane transporter activity|regulation of bone development|mitochondrial inner membrane|mitochondrion|positive regulation of myeloid cell differentiation|cell differentiation|skeletal system development|regulation of myeloid cell differentiation|ion transmembrane transport|leukocyte differentiation|regulation of myeloid leukocyte differentiation|cation transmembrane transport|regulation of osteoclast development|proton transport|antiporter activity|cation transport|osteoclast development|positive regulation of myeloid leukocyte differentiation|myeloid cell differentiation|cation transmembrane transporter activity|myeloid leukocyte differentiation|positive regulation of osteoclast differentiation|hydrogen ion transmembrane transport|inorganic cation transmembrane transporter activity|metal ion transport|regulation of osteoclast differentiation|monovalent inorganic cation transport|sodium ion transport|osteoclast differentiation|solute:proton antiporter activity|monovalent inorganic cation transmembrane transporter activity|hydrogen ion transmembrane transporter activity - - - - 4:103019868-103085829 126 156 152 63 63 44 1.06117710407932 1.19404918732407 1.15418465413567 0.475393906262707 0.435339214358019 0.347294366040196 1.13647031517969 0.419342495553641 1.43835905787422 1.01620050303523e-07 1.56138187429818e-06 UP ENSG00000138380 CARF calcium responsive transcription factor [Source:HGNC Symbol;Acc:HGNC:14435] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0010035|GO:0044249|GO:0031323|GO:0000982|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:1901522|GO:0051252|GO:0010628|GO:0010038|GO:0031981|GO:0005654|GO:0071241|GO:0010467|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0061400|GO:0045893|GO:0032774|GO:0043565|GO:0051592|GO:2001141|GO:0001077|GO:0003690|GO:0035864|GO:0006351|GO:0006355|GO:0071248|GO:0045944|GO:0006366|GO:0006357|GO:0071277|GO:1903506|GO:0044212|GO:0035865|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|response to inorganic substance|cellular biosynthetic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|regulation of RNA metabolic process|positive regulation of gene expression|response to metal ion|nuclear lumen|nucleoplasm|cellular response to inorganic substance|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription from RNA polymerase II promoter in response to calcium ion|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|response to calcium ion|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|response to potassium ion|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular response to metal ion|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|cellular response to calcium ion|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|cellular response to potassium ion|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 2:202912214-202987063 18 18 17 96 54 93 0.0766430141465039 0.06965457397359 0.065261753432087 0.366241467261783 0.188652109705024 0.371115993762849 0.0705197805173936 0.308669856909885 -2.12996471415187 1.01847768664958e-07 1.56407576426114e-06 DOWN ENSG00000185338 SOCS1 suppressor of cytokine signaling 1 [Source:HGNC Symbol;Acc:HGNC:19383] GO:0032502|GO:0040007|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0051707|GO:0043227|GO:0040008|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0030234|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:0051726|GO:0007049|GO:0004857|GO:0045087|GO:0006810|GO:0007275|GO:0048513|GO:0005102|GO:0032940|GO:0006952|GO:0031982|GO:0031325|GO:1900076|GO:0001817|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0001816|GO:0032880|GO:0009966|GO:0045184|GO:0042493|GO:0010646|GO:0043085|GO:0009617|GO:0050776|GO:0008104|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0009725|GO:0050790|GO:0019207|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:1902533|GO:0032268|GO:0005829|GO:0005159|GO:0034340|GO:0019210|GO:0007166|GO:0001959|GO:0033993|GO:0043412|GO:0034097|GO:0031410|GO:0002237|GO:0019887|GO:0031100|GO:0051223|GO:0015031|GO:1901652|GO:0071417|GO:0043200|GO:0016023|GO:0051347|GO:0036211|GO:0032269|GO:0070201|GO:0051046|GO:0034341|GO:0043434|GO:0009306|GO:0051247|GO:0031988|GO:0050663|GO:0019900|GO:0032270|GO:0014070|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0046903|GO:0071310|GO:1902532|GO:0046627|GO:0051246|GO:0030154|GO:0046626|GO:0050707|GO:1902531|GO:0060330|GO:0032870|GO:0032496|GO:0005634|GO:0048545|GO:0097305|GO:0045088|GO:0045444|GO:0019221|GO:0060334|GO:0031401|GO:0071346|GO:1901653|GO:0060338|GO:0032570|GO:0050708|GO:0071357|GO:0016310|GO:0043627|GO:0060416|GO:1904030|GO:0007167|GO:0071375|GO:0004860|GO:0032355|GO:0071345|GO:0033673|GO:0032868|GO:0019901|GO:0006464|GO:0043549|GO:0071230|GO:0033674|GO:0007259|GO:0045859|GO:0045860|GO:0006469|GO:0060333|GO:0006468|GO:0046425|GO:0042325|GO:0071378|GO:0046426|GO:0001932|GO:0032869|GO:0018193|GO:0042326|GO:0046427|GO:0001934|GO:0001933|GO:0042327|GO:0060337|GO:0007169|GO:0032446|GO:0060397|GO:0050730|GO:0060396|GO:0007260|GO:0042976|GO:0050732|GO:0032147|GO:0008286|GO:0018108|GO:0042516|GO:0042508|GO:0010534|GO:0042518|GO:0042977|GO:0016567|GO:0042503|GO:0042510 developmental process|growth|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|immune response|cellular metabolic process|cellular localization|regulation of signaling|response to other organism|membrane-bounded organelle|regulation of growth|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of immune system process|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|cell cycle|enzyme inhibitor activity|innate immune response|transport|multicellular organism development|animal organ development|receptor binding|secretion by cell|defense response|vesicle|positive regulation of cellular metabolic process|regulation of cellular response to insulin stimulus|regulation of cytokine production|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|cytokine production|regulation of protein localization|regulation of signal transduction|establishment of protein localization|response to drug|regulation of cell communication|positive regulation of catalytic activity|response to bacterium|regulation of immune response|protein localization|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|response to hormone|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|insulin-like growth factor receptor binding|response to type I interferon|kinase inhibitor activity|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|response to lipid|macromolecule modification|response to cytokine|cytoplasmic vesicle|response to molecule of bacterial origin|protein kinase regulator activity|organ regeneration|regulation of protein transport|protein transport|response to peptide|cellular response to organonitrogen compound|response to amino acid|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|regulation of secretion|response to interferon-gamma|response to peptide hormone|protein secretion|positive regulation of protein metabolic process|membrane-bounded vesicle|cytokine secretion|kinase binding|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|secretion|cellular response to organic substance|negative regulation of intracellular signal transduction|negative regulation of insulin receptor signaling pathway|regulation of protein metabolic process|cell differentiation|regulation of insulin receptor signaling pathway|regulation of cytokine secretion|regulation of intracellular signal transduction|regulation of response to interferon-gamma|cellular response to hormone stimulus|response to lipopolysaccharide|nucleus|response to steroid hormone|response to alcohol|regulation of innate immune response|fat cell differentiation|cytokine-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|positive regulation of protein modification process|cellular response to interferon-gamma|cellular response to peptide|regulation of type I interferon-mediated signaling pathway|response to progesterone|regulation of protein secretion|cellular response to type I interferon|phosphorylation|response to estrogen|response to growth hormone|negative regulation of cyclin-dependent protein kinase activity|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|protein kinase inhibitor activity|response to estradiol|cellular response to cytokine stimulus|negative regulation of kinase activity|response to insulin|protein kinase binding|cellular protein modification process|regulation of kinase activity|cellular response to amino acid stimulus|positive regulation of kinase activity|JAK-STAT cascade|regulation of protein kinase activity|positive regulation of protein kinase activity|negative regulation of protein kinase activity|interferon-gamma-mediated signaling pathway|protein phosphorylation|regulation of JAK-STAT cascade|regulation of phosphorylation|cellular response to growth hormone stimulus|negative regulation of JAK-STAT cascade|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|negative regulation of phosphorylation|positive regulation of JAK-STAT cascade|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|positive regulation of phosphorylation|type I interferon signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|JAK-STAT cascade involved in growth hormone signaling pathway|regulation of peptidyl-tyrosine phosphorylation|growth hormone receptor signaling pathway|tyrosine phosphorylation of STAT protein|activation of Janus kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|activation of protein kinase activity|insulin receptor signaling pathway|peptidyl-tyrosine phosphorylation|regulation of tyrosine phosphorylation of Stat3 protein|tyrosine phosphorylation of Stat1 protein|regulation of activation of JAK2 kinase activity|negative regulation of tyrosine phosphorylation of Stat3 protein|activation of JAK2 kinase activity|protein ubiquitination|tyrosine phosphorylation of Stat3 protein|regulation of tyrosine phosphorylation of Stat1 protein K04694 suppressor of cytokine signaling 1[-] hsa05206|hsa04630|hsa04910|hsa04120|hsa04380|hsa05145|hsa04917|hsa04930 MicroRNAs in cancer - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Type II diabetes mellitus - Homo sapiens (human) 16:11254405-11256179 53 62 61 18 20 19 3.0604444805102 3.25372467665495 3.17580493817871 0.931258145886514 0.94754404860951 1.02822056789996 3.16332469844795 0.969007587465328 1.70686178112338 1.0232996082568e-07 1.57067282801534e-06 UP ENSG00000168014 C2CD3 C2 calcium-dependent domain containing 3 [Source:HGNC Symbol;Acc:HGNC:24564] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0071704|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0019222|GO:0007507|GO:0007049|GO:0035239|GO:0009888|GO:0022402|GO:0035295|GO:0007275|GO:0048513|GO:0007420|GO:0022607|GO:0005737|GO:0007389|GO:0060322|GO:0009887|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0036064|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0030030|GO:0048869|GO:0007017|GO:0019538|GO:0006996|GO:0031023|GO:0000902|GO:0005829|GO:0005813|GO:0003143|GO:0042733|GO:0007166|GO:0002009|GO:0007010|GO:0072358|GO:0007417|GO:0060896|GO:0009798|GO:0009880|GO:0035050|GO:0005815|GO:0003007|GO:0051604|GO:0007098|GO:0008589|GO:0098534|GO:0009790|GO:0005814|GO:0044782|GO:0030031|GO:0007099|GO:0006508|GO:0061371|GO:0061511|GO:0034613|GO:0070925|GO:0060429|GO:0042384|GO:0035108|GO:0010467|GO:0051298|GO:0032990|GO:0048562|GO:0007399|GO:0060562|GO:0051246|GO:0048858|GO:0060173|GO:0072359|GO:0000226|GO:0005856|GO:0060271|GO:0001840|GO:0035058|GO:0000578|GO:0033365|GO:0009792|GO:0016485|GO:0030162|GO:0007224|GO:0001947|GO:0015630|GO:0009855|GO:0051297|GO:0034451|GO:0030326|GO:0021997|GO:0007368|GO:0044380|GO:0043009|GO:0001701|GO:0071539 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|cell cycle|tube morphogenesis|tissue development|cell cycle process|tube development|multicellular organism development|animal organ development|brain development|cellular component assembly|cytoplasm|pattern specification process|head development|organ morphogenesis|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|ciliary basal body|regulation of cell communication|protein localization|cell communication|signal transduction|cell projection organization|cellular developmental process|microtubule-based process|protein metabolic process|organelle organization|microtubule organizing center organization|cell morphogenesis|cytosol|centrosome|embryonic heart tube morphogenesis|embryonic digit morphogenesis|cell surface receptor signaling pathway|morphogenesis of an epithelium|cytoskeleton organization|cardiovascular system development|central nervous system development|neural plate pattern specification|axis specification|embryonic pattern specification|embryonic heart tube development|microtubule organizing center|heart morphogenesis|protein maturation|centrosome cycle|regulation of smoothened signaling pathway|centriole assembly|embryo development|centriole|cilium organization|cell projection assembly|centriole replication|proteolysis|determination of heart left/right asymmetry|centriole elongation|cellular protein localization|organelle assembly|epithelium development|cilium assembly|limb morphogenesis|gene expression|centrosome duplication|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|regulation of protein metabolic process|cell projection morphogenesis|limb development|circulatory system development|microtubule cytoskeleton organization|cytoskeleton|cilium morphogenesis|neural plate development|nonmotile primary cilium assembly|embryonic axis specification|protein localization to organelle|embryo development ending in birth or egg hatching|protein processing|regulation of proteolysis|smoothened signaling pathway|heart looping|microtubule cytoskeleton|determination of bilateral symmetry|centrosome organization|centriolar satellite|embryonic limb morphogenesis|neural plate axis specification|determination of left/right symmetry|protein localization to cytoskeleton|chordate embryonic development|in utero embryonic development|protein localization to centrosome - - - - 11:74012714-74171210 474 571 694 1237 1451 1291 1.72440336865891 1.88788726145888 2.27632346038396 4.03206406957697 4.33107175789257 4.40164656596869 1.96287136350058 4.25492746447941 -1.11616890881274 1.02412471819617e-07 1.57113151783291e-06 DOWN ENSG00000140987 ZSCAN32 zinc finger and SCAN domain containing 32 [Source:HGNC Symbol;Acc:HGNC:20812] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0000981|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 16:3382081-3401065 891 972 434 254 277 295 4.13099254106581 4.09564910992799 1.81417974272023 1.05513689561773 1.05371944683375 1.28182230928039 3.34694046457134 1.13022621724396 1.56623132846794 1.03539369644958e-07 1.58760366788936e-06 UP ENSG00000148331 ASB6 ankyrin repeat and SOCS box containing 6 [Source:HGNC Symbol;Acc:HGNC:17181] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0005737|GO:0007154|GO:0007165|GO:0019538|GO:0043412|GO:0036211|GO:0035556|GO:0044267|GO:0006464|GO:0032446|GO:0016567 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|cytoplasm|cell communication|signal transduction|protein metabolic process|macromolecule modification|protein modification process|intracellular signal transduction|cellular protein metabolic process|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination - - - - 9:129634604-129642169 747 930 709 418 428 334 7.88075411004668 8.91681607499632 6.74384351520947 3.95112583664255 3.70474406510816 3.30233991191999 7.84713790008416 3.6527366045569 1.10318882728056 1.03754235276687e-07 1.59008159135021e-06 UP ENSG00000115008 IL1A interleukin 1 alpha [Source:HGNC Symbol;Acc:HGNC:5991] GO:0032502|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0003006|GO:0023051|GO:0009653|GO:0016043|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0060341|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:0048468|GO:0006810|GO:0022402|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0051302|GO:0005102|GO:0034641|GO:0032940|GO:0006952|GO:0031325|GO:0046483|GO:0042094|GO:0051128|GO:0033554|GO:0001817|GO:0002437|GO:0043169|GO:0005737|GO:0001816|GO:0009611|GO:0032880|GO:0009408|GO:0051222|GO:0042592|GO:0009966|GO:0045184|GO:0048771|GO:0045787|GO:0048871|GO:0001819|GO:0035234|GO:0060548|GO:0010646|GO:0006139|GO:0001525|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0008285|GO:0051047|GO:0051781|GO:0051301|GO:0048869|GO:0010035|GO:0009967|GO:0044249|GO:0009266|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0006996|GO:0042107|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0010574|GO:0010468|GO:0005126|GO:0034645|GO:0042089|GO:0090068|GO:0046872|GO:0007166|GO:0070851|GO:1903047|GO:0001944|GO:0043412|GO:0072358|GO:0034097|GO:0032623|GO:0010623|GO:0043069|GO:2001234|GO:0051252|GO:0001659|GO:0051223|GO:0015031|GO:0005125|GO:0010628|GO:0010038|GO:0036211|GO:0010575|GO:0000278|GO:0070201|GO:0042060|GO:0006954|GO:0050714|GO:0050715|GO:0032743|GO:0045766|GO:0051046|GO:0031098|GO:0045765|GO:0007346|GO:0042035|GO:0010564|GO:0009306|GO:0034605|GO:0051247|GO:0046688|GO:0042108|GO:0050663|GO:0032270|GO:0012501|GO:0006796|GO:1901342|GO:0002248|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0007067|GO:0010467|GO:0046903|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0050707|GO:1902531|GO:0016070|GO:0045931|GO:0072359|GO:0010557|GO:0045076|GO:0043067|GO:0010573|GO:0097190|GO:0010638|GO:0045086|GO:2001237|GO:0070304|GO:0045893|GO:0019221|GO:0031401|GO:0043122|GO:0043408|GO:0007088|GO:0032774|GO:2001240|GO:2001141|GO:0097192|GO:2001236|GO:0050708|GO:0016310|GO:0002526|GO:0070371|GO:0043123|GO:0007249|GO:0043410|GO:0032872|GO:0042981|GO:0071345|GO:0045840|GO:0046914|GO:0043066|GO:0002246|GO:0005149|GO:0031649|GO:0006464|GO:0097191|GO:0051403|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0046328|GO:0006357|GO:0005507|GO:0006468|GO:1903506|GO:2001239|GO:0042325|GO:0070374|GO:0001660|GO:0007254|GO:0001932|GO:0032874|GO:0001934|GO:0006953|GO:0070372|GO:0042327|GO:0046330 developmental process|reproduction|immune system process|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|cellular component organization|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|extracellular space|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|cell development|transport|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|secretion by cell|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|interleukin-2 biosynthetic process|regulation of cellular component organization|cellular response to stress|regulation of cytokine production|inflammatory response to antigenic stimulus|cation binding|cytoplasm|cytokine production|response to wounding|regulation of protein localization|response to heat|positive regulation of protein transport|homeostatic process|regulation of signal transduction|establishment of protein localization|tissue remodeling|positive regulation of cell cycle|multicellular organismal homeostasis|positive regulation of cytokine production|ectopic germ cell programmed cell death|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|protein localization|cell communication|signal transduction|negative regulation of signal transduction|cell death|negative regulation of cell proliferation|positive regulation of secretion|positive regulation of cell division|cell division|cellular developmental process|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|organelle organization|cytokine metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|regulation of vascular endothelial growth factor production|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|cytokine biosynthetic process|positive regulation of cell cycle process|metal ion binding|cell surface receptor signaling pathway|growth factor receptor binding|mitotic cell cycle process|vasculature development|macromolecule modification|cardiovascular system development|response to cytokine|interleukin-2 production|developmental programmed cell death|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|temperature homeostasis|regulation of protein transport|protein transport|cytokine activity|positive regulation of gene expression|response to metal ion|protein modification process|positive regulation of vascular endothelial growth factor production|mitotic cell cycle|regulation of establishment of protein localization|wound healing|inflammatory response|positive regulation of protein secretion|positive regulation of cytokine secretion|positive regulation of interleukin-2 production|positive regulation of angiogenesis|regulation of secretion|stress-activated protein kinase signaling cascade|regulation of angiogenesis|regulation of mitotic cell cycle|regulation of cytokine biosynthetic process|regulation of cell cycle process|protein secretion|cellular response to heat|positive regulation of protein metabolic process|response to copper ion|positive regulation of cytokine biosynthetic process|cytokine secretion|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|regulation of vasculature development|connective tissue replacement involved in inflammatory response wound healing|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|gene expression|secretion|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|regulation of cytokine secretion|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of mitotic cell cycle|circulatory system development|positive regulation of macromolecule biosynthetic process|regulation of interleukin-2 biosynthetic process|regulation of programmed cell death|vascular endothelial growth factor production|apoptotic signaling pathway|positive regulation of organelle organization|positive regulation of interleukin-2 biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of MAPK cascade|regulation of mitotic nuclear division|RNA biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|regulation of extrinsic apoptotic signaling pathway|regulation of protein secretion|phosphorylation|acute inflammatory response|ERK1 and ERK2 cascade|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|positive regulation of mitotic nuclear division|transition metal ion binding|negative regulation of apoptotic process|wound healing involved in inflammatory response|interleukin-1 receptor binding|heat generation|cellular protein modification process|extrinsic apoptotic signaling pathway|stress-activated MAPK cascade|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|copper ion binding|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|fever generation|JNK cascade|regulation of protein phosphorylation|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|acute-phase response|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|positive regulation of JNK cascade K04383 interleukin 1 alpha[-] hsa04060|hsa04010|hsa05152|hsa05164|hsa04932|hsa05162|hsa04380|hsa04933|hsa05323|hsa04640|hsa05132|hsa05133|hsa05140|hsa05321|hsa04940|hsa05332|hsa05020 Cytokine-cytokine receptor interaction - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Measles - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human)|Inflammatory bowel disease (IBD) - Homo sapiens (human)|Type I diabetes mellitus - Homo sapiens (human)|Graft-versus-host disease - Homo sapiens (human)|Prion diseases - Homo sapiens (human) 2:112773915-112784590 34 34 44 7 11 10 1.13233223264379 1.0290811067271 1.32117115795747 0.208867188861497 0.30056727715782 0.31211298047438 1.16086149910945 0.273849148831232 2.08374255503368 1.04173216709871e-07 1.59568353599615e-06 UP ENSG00000117266 CDK18 cyclin-dependent kinase 18 [Source:HGNC Symbol;Acc:HGNC:8751] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0005515|GO:0016740|GO:0051726|GO:0007049|GO:0043168|GO:0001882|GO:0016772|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674|GO:0097472|GO:0004693 cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|protein binding|transferase activity|regulation of cell cycle|cell cycle|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity|cyclin-dependent protein kinase activity|cyclin-dependent protein serine/threonine kinase activity - - - - 1:205504595-205532793 79 65 182 366 355 614 0.322308420015352 0.241014249613415 0.669470049696226 1.33790648492081 1.1883465928053 2.34770589848586 0.410930906441664 1.62465299207066 -1.98316386137808 1.0434178730424e-07 1.59744600932347e-06 DOWN ENSG00000121690 DEPDC7 DEP domain containing 7 [Source:HGNC Symbol;Acc:HGNC:29899] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0023051|GO:0005622|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0005829|GO:0035556|GO:1902531|GO:0051056|GO:0007264 signaling|cell|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of signaling|intracellular|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|cytosol|intracellular signal transduction|regulation of intracellular signal transduction|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 11:33015864-33033582 103 113 192 31 45 55 1.50691239273628 1.50248098440387 2.53258577902798 0.406351655324469 0.540173926714814 0.754113566965234 1.84732638538938 0.566879716334839 1.70432423025486 1.04621424848513e-07 1.60090621088033e-06 UP ENSG00000104442 ARMC1 armadillo repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:17684] GO:0005623|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0006810|GO:0043231|GO:0043169|GO:0005737|GO:0046872|GO:0006811|GO:0005739|GO:0006812|GO:0030001 cell|binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|transport|intracellular membrane-bounded organelle|cation binding|cytoplasm|metal ion binding|ion transport|mitochondrion|cation transport|metal ion transport - - - - 8:65602456-65634217 249 285 456 793 851 812 2.55898379136341 2.66190781885699 4.22520085407675 7.3019492931281 7.17571932866852 7.82083319115875 3.14869748809905 7.43283393765179 -1.23915721923397 1.05242314742648e-07 1.60958200016752e-06 DOWN ENSG00000174529 TMEM81 transmembrane protein 81 [Source:HGNC Symbol;Acc:HGNC:32349] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 1:205083129-205084460 127 101 115 41 44 42 6.74443933227087 4.87466061159451 5.5062380696229 1.95083992459621 1.91717545651785 2.09035577298511 5.70844600449609 1.98612371803306 1.52314256502003 1.05411102422695e-07 1.61090818122638e-06 UP ENSG00000232445 RP11-132A1.4 - - - - - - - 7:101308346-101310985 221 253 200 92 97 48 22.1742030517843 23.0705217739893 18.0925910036511 8.27070366693994 7.98537869365531 4.51367216827359 21.1124386098082 6.92325150962295 1.60857156319444 1.05436946007783e-07 1.61090818122638e-06 UP ENSG00000127589 TUBBP1 tubulin beta pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:12414] - - - - - - 8:30351873-30353518 423 392 31 27 23 20 10.0374779394415 8.45376828725628 0.663229197491194 0.574052653900877 0.447793700419582 0.444768849733367 6.38482514139632 0.488871734684609 3.70711921004144 1.0694092179431e-07 1.6330507822237e-06 UP ENSG00000143156 NME7 NME/NM23 family member 7 [Source:HGNC Symbol;Acc:HGNC:20461] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0043169|GO:0006139|GO:0055086|GO:0000166|GO:0044249|GO:0005813|GO:0046872|GO:0035639|GO:0019693|GO:0005815|GO:0001883|GO:0009116|GO:0032549|GO:0016301|GO:0006796|GO:1901137|GO:0017076|GO:0005856|GO:0016776|GO:0006213|GO:0009142|GO:0009259|GO:0009117|GO:0006220|GO:0005524|GO:0046390|GO:0004550|GO:0030554|GO:0016310|GO:0019205|GO:0015630|GO:0009132|GO:0006163|GO:0009165|GO:0042278|GO:0006164|GO:0046939|GO:0046134|GO:0006165|GO:0006221|GO:0046051|GO:0009152|GO:0009220|GO:0046039|GO:0006241|GO:0006183|GO:0006228 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|cation binding|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|nucleotide binding|cellular biosynthetic process|centrosome|metal ion binding|purine ribonucleoside triphosphate binding|ribose phosphate metabolic process|microtubule organizing center|purine nucleoside binding|nucleoside metabolic process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|purine nucleotide binding|cytoskeleton|phosphotransferase activity, phosphate group as acceptor|pyrimidine nucleoside metabolic process|nucleoside triphosphate biosynthetic process|ribonucleotide metabolic process|nucleotide metabolic process|pyrimidine nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|nucleoside diphosphate kinase activity|adenyl nucleotide binding|phosphorylation|nucleobase-containing compound kinase activity|microtubule cytoskeleton|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|nucleotide biosynthetic process|purine nucleoside metabolic process|purine nucleotide biosynthetic process|nucleotide phosphorylation|pyrimidine nucleoside biosynthetic process|nucleoside diphosphate phosphorylation|pyrimidine nucleotide biosynthetic process|UTP metabolic process|purine ribonucleotide biosynthetic process|pyrimidine ribonucleotide biosynthetic process|GTP metabolic process|CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process K00940 nucleoside-diphosphate kinase[2.7.4.6] hsa01100|hsa00230|hsa00240 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human) 1:169132531-169367967 42 76 85 231 241 182 0.365204937396525 0.600594340259285 0.66637585111694 1.799692202285 1.7193845393411 1.48315753048594 0.544058376257583 1.66741142403735 -1.61577676195746 1.07474118819763e-07 1.64035395871431e-06 DOWN ENSG00000070269 TMEM260 transmembrane protein 260 [Source:HGNC Symbol;Acc:HGNC:20185] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 14:56488354-56650606 234 305 406 724 760 799 1.28502824790446 1.52221547696406 2.01018722359509 3.56231647001469 3.42434509445367 4.1121760058485 1.60581031615454 3.69961252343895 -1.20407269209539 1.09356790378677e-07 1.66738387127938e-06 DOWN ENSG00000265808 SEC22B SEC22 homolog B, vesicle trafficking protein (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:10700] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0006486|GO:0051640|GO:0006810|GO:0031982|GO:0051128|GO:0022607|GO:0051668|GO:0043231|GO:0030133|GO:0005737|GO:0012506|GO:0006903|GO:0005975|GO:0051656|GO:0005484|GO:0045184|GO:0030658|GO:0000149|GO:0008104|GO:0061024|GO:0005783|GO:0051649|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006996|GO:0061025|GO:0016192|GO:0051650|GO:0012507|GO:0045732|GO:0034645|GO:0006900|GO:0016050|GO:0043412|GO:0005793|GO:0006487|GO:0090114|GO:0030163|GO:0031410|GO:0015031|GO:0033116|GO:0016023|GO:0009100|GO:0036211|GO:0046907|GO:0048199|GO:0051247|GO:0031988|GO:0070085|GO:0006461|GO:0030659|GO:1901137|GO:0033043|GO:0044267|GO:0042176|GO:0000139|GO:0051648|GO:0051246|GO:0009059|GO:0019905|GO:0030134|GO:0048284|GO:0009101|GO:0043413|GO:0048208|GO:0018279|GO:0048193|GO:0006906|GO:0030135|GO:0006464|GO:0048280|GO:0042470|GO:0018193|GO:0043687|GO:0006888 cell|membrane|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|protein glycosylation|organelle localization|transport|vesicle|regulation of cellular component organization|cellular component assembly|localization within membrane|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|vesicle membrane|vesicle targeting|carbohydrate metabolic process|establishment of organelle localization|SNAP receptor activity|establishment of protein localization|transport vesicle membrane|SNARE binding|protein localization|membrane organization|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|organelle organization|membrane fusion|vesicle-mediated transport|establishment of vesicle localization|ER to Golgi transport vesicle membrane|positive regulation of protein catabolic process|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation|COPII-coated vesicle budding|protein catabolic process|cytoplasmic vesicle|protein transport|endoplasmic reticulum-Golgi intermediate compartment membrane|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|protein modification process|intracellular transport|vesicle targeting, to, from or within Golgi|positive regulation of protein metabolic process|membrane-bounded vesicle|glycosylation|protein complex assembly|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|Golgi membrane|vesicle localization|regulation of protein metabolic process|macromolecule biosynthetic process|syntaxin binding|ER to Golgi transport vesicle|organelle fusion|glycoprotein biosynthetic process|macromolecule glycosylation|COPII vesicle coating|protein N-linked glycosylation via asparagine|Golgi vesicle transport|vesicle fusion|coated vesicle|cellular protein modification process|vesicle fusion with Golgi apparatus|melanosome|peptidyl-amino acid modification|post-translational protein modification|ER to Golgi vesicle-mediated transport K08517 vesicle transport protein SEC22[-] hsa04145|hsa05134|hsa04130 Phagosome - Homo sapiens (human)|Legionellosis - Homo sapiens (human)|SNARE interactions in vesicular transport - Homo sapiens (human) 1:120150898-120176515 662 805 1181 1922 2105 2430 5.1166745282997 5.65465138195198 8.22988530722065 13.310084696762 13.349029707193 17.6021197088309 6.33373707249078 14.753744704262 -1.2199522926453 1.10492941719577e-07 1.68298789902869e-06 DOWN ENSG00000136451 VEZF1 vascular endothelial zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:12949] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0001568|GO:0007275|GO:0003676|GO:0034641|GO:0006952|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0001525|GO:0048869|GO:0044249|GO:0031323|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0001944|GO:0072358|GO:0002064|GO:0051252|GO:0031981|GO:0005654|GO:0060429|GO:0010467|GO:0006968|GO:0009059|GO:0030154|GO:0016070|GO:0072359|GO:0005634|GO:0003158|GO:0001885|GO:0030855|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0045446|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|angiogenesis|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|vasculature development|cardiovascular system development|epithelial cell development|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|epithelium development|gene expression|cellular defense response|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|circulatory system development|nucleus|endothelium development|endothelial cell development|epithelial cell differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|endothelial cell differentiation|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 17:57971547-57988259 390 554 582 1071 1180 1314 3.96199174318734 5.11492549204656 5.33073269928694 9.74847292049294 9.83556294455391 12.510469556604 4.80254997817361 10.6981684738836 -1.15549129580044 1.10714930234044e-07 1.68550919286443e-06 DOWN ENSG00000186501 TMEM222 transmembrane protein 222 [Source:HGNC Symbol;Acc:HGNC:25363] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 1:27322145-27336400 610 621 492 250 321 219 4.22536831441908 3.90936594357227 3.07265967510166 1.55157659675013 1.82435128362949 1.42170110391997 3.73579797769767 1.5992096614332 1.2240573468463 1.10831695981635e-07 1.68642683579803e-06 UP ENSG00000180901 KCTD2 potassium channel tetramerization domain containing 2 [Source:HGNC Symbol;Acc:HGNC:21294] GO:0009987|GO:0005488|GO:0044877|GO:0016043|GO:0005515|GO:0022607|GO:0032403|GO:0006461|GO:0051259|GO:0051260 cellular process|binding|macromolecular complex binding|cellular component organization|protein binding|cellular component assembly|protein complex binding|protein complex assembly|protein oligomerization|protein homooligomerization - - - - 17:75032575-75065889 1135 1187 989 559 586 582 8.07872184441337 7.67851870012368 6.34683619340743 3.56497388008631 3.42225263263739 3.88238775061478 7.36802557931483 3.62320475444616 1.02401173235454 1.11885624820716e-07 1.70072985916377e-06 UP ENSG00000165124 SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:15985] GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:0044877|GO:0043167|GO:0007155|GO:0005622|GO:0005515|GO:0043169|GO:0005737|GO:0003682|GO:0046872|GO:0005509 cell|membrane|extracellular region|binding|macromolecular complex binding|ion binding|cell adhesion|intracellular|protein binding|cation binding|cytoplasm|chromatin binding|metal ion binding|calcium ion binding - - - - 9:110365251-110579880 2 5 10 47 31 34 0.00824833105336891 0.0187433347940772 0.0371862002196452 0.173681062049045 0.104903765236942 0.131420757381145 0.0213926220223638 0.136668528222377 -2.67549583525134 1.12290631390929e-07 1.70601756210931e-06 DOWN ENSG00000139218 SCAF11 SR-related CTD-associated factor 11 [Source:HGNC Symbol;Acc:HGNC:10784] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0006139|GO:0022613|GO:0005730|GO:0046872|GO:0003723|GO:0022618|GO:0031981|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0034622|GO:0006396|GO:0016071|GO:0046914|GO:0044822|GO:0000245|GO:0006397|GO:0008380|GO:0008270|GO:0000375|GO:0000398 cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|nucleolus|metal ion binding|RNA binding|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|gene expression|RNA metabolic process|nucleus|cellular macromolecular complex assembly|RNA processing|mRNA metabolic process|transition metal ion binding|poly(A) RNA binding|spliceosomal complex assembly|mRNA processing|RNA splicing|zinc ion binding|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 12:45919131-45992120 891 1028 1167 2278 2602 2082 2.79894098938809 2.93487020990315 3.30522623466041 6.41161334284812 6.70642623772013 6.12950834874358 3.01301247798388 6.41584930977061 -1.09043360967651 1.1259283139451e-07 1.70973875302732e-06 DOWN ENSG00000128641 MYO1B myosin IB [Source:HGNC Symbol;Acc:HGNC:7596] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042995|GO:0097159|GO:0044877|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0005903|GO:0006810|GO:0005884|GO:0043168|GO:0005543|GO:0001882|GO:0031982|GO:0016817|GO:0022607|GO:0043231|GO:0005737|GO:0006928|GO:0032403|GO:0016459|GO:0005516|GO:0070062|GO:0051649|GO:0008092|GO:0010008|GO:0000166|GO:0030029|GO:0005794|GO:0005768|GO:0006996|GO:0051017|GO:0016192|GO:0005802|GO:0035639|GO:0007010|GO:0005769|GO:0035091|GO:0030048|GO:0001883|GO:0003779|GO:0016818|GO:0046907|GO:0032549|GO:0048471|GO:0030175|GO:0030036|GO:0051015|GO:0000139|GO:0017076|GO:0005856|GO:0015629|GO:0005524|GO:0030554|GO:0048193|GO:1901981|GO:0007015|GO:0016462|GO:0032588|GO:1902936|GO:0017111|GO:0005547|GO:0006892|GO:0061572|GO:0016887|GO:0003774|GO:0005546|GO:0000146|GO:0042623|GO:0030898 macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|cell projection|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|brush border|transport|actin filament|anion binding|phospholipid binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|protein complex binding|myosin complex|calmodulin binding|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|endosome membrane|nucleotide binding|actin filament-based process|Golgi apparatus|endosome|organelle organization|actin filament bundle assembly|vesicle-mediated transport|trans-Golgi network|purine ribonucleoside triphosphate binding|cytoskeleton organization|early endosome|phosphatidylinositol binding|actin filament-based movement|purine nucleoside binding|actin binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|perinuclear region of cytoplasm|filopodium|actin cytoskeleton organization|actin filament binding|Golgi membrane|purine nucleotide binding|cytoskeleton|actin cytoskeleton|ATP binding|adenyl nucleotide binding|Golgi vesicle transport|phosphatidylinositol phosphate binding|actin filament organization|pyrophosphatase activity|trans-Golgi network membrane|phosphatidylinositol bisphosphate binding|nucleoside-triphosphatase activity|phosphatidylinositol-3,4,5-trisphosphate binding|post-Golgi vesicle-mediated transport|actin filament bundle organization|ATPase activity|motor activity|phosphatidylinositol-4,5-bisphosphate binding|microfilament motor activity|ATPase activity, coupled|actin-dependent ATPase activity - - - - 2:191245185-191425389 871 1086 1392 2799 3319 2109 4.71074361030116 5.33803285851372 6.7877293514064 13.5634996095806 14.7280893571483 10.6899759670049 5.61216860674043 12.9938549779113 -1.21119925102486 1.12828868036312e-07 1.71245197069449e-06 DOWN ENSG00000178904 DPY19L3 dpy-19-like 3 (C. elegans) [Source:HGNC Symbol;Acc:HGNC:27120] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0019866|GO:0043231|GO:0005975|GO:0005635|GO:0016757|GO:0031965|GO:0016021|GO:0044249|GO:0019538|GO:0034645|GO:0043412|GO:0009100|GO:0036211|GO:0005637|GO:0016758|GO:0070085|GO:0035268|GO:1901137|GO:0044267|GO:0009059|GO:0005634|GO:0097502|GO:0009101|GO:0043413|GO:0000030|GO:0018406|GO:0006464|GO:0018193 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|organelle inner membrane|intracellular membrane-bounded organelle|carbohydrate metabolic process|nuclear envelope|transferase activity, transferring glycosyl groups|nuclear membrane|integral component of membrane|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|glycoprotein metabolic process|protein modification process|nuclear inner membrane|transferase activity, transferring hexosyl groups|glycosylation|protein mannosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|nucleus|mannosylation|glycoprotein biosynthetic process|macromolecule glycosylation|mannosyltransferase activity|protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan|cellular protein modification process|peptidyl-amino acid modification - - - - 19:32405543-32485895 98 233 175 492 564 509 0.328012703400429 0.708761796587539 0.528099684481548 1.47545914598135 1.54885667028409 1.59665351576997 0.521624728156505 1.54032311067847 -1.56214884534354 1.13421558186277e-07 1.72057276325869e-06 DOWN ENSG00000132003 ZSWIM4 zinc finger, SWIM-type containing 4 [Source:HGNC Symbol;Acc:HGNC:25704] GO:0005488|GO:0043167|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 19:13795460-13832230 538 639 773 307 342 356 6.00733163563268 6.48454876924756 7.78202566701841 3.07138887278165 3.1332407254231 3.72544389234168 6.75796869063288 3.31002449684881 1.02974777239754 1.13492540219528e-07 1.72077516288156e-06 UP ENSG00000177034 MTX3 metaxin 3 [Source:HGNC Symbol;Acc:HGNC:24812] GO:0005623|GO:0016020|GO:0009987|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0019867|GO:0005622|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0031966|GO:0045184|GO:0008104|GO:0051649|GO:0006996|GO:0005740|GO:0072594|GO:0007005|GO:0005741|GO:0015031|GO:0046907|GO:0005739|GO:0034613|GO:0006626|GO:0033365|GO:0006839|GO:0006605|GO:0072655|GO:0006886|GO:0070585 cell|membrane|cellular process|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|outer membrane|intracellular|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|establishment of protein localization|protein localization|establishment of localization in cell|organelle organization|mitochondrial envelope|establishment of protein localization to organelle|mitochondrion organization|mitochondrial outer membrane|protein transport|intracellular transport|mitochondrion|cellular protein localization|protein targeting to mitochondrion|protein localization to organelle|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|intracellular protein transport|protein localization to mitochondrion - - - - 5:79976731-79991262 318 313 356 133 153 170 1.84198601315909 1.64771994557866 1.85918651946007 0.690252609298625 0.727140338304645 0.922861697446783 1.78296415939927 0.780084881683351 1.19257468416609 1.15124331541491e-07 1.74463035220288e-06 UP ENSG00000249685 RP11-360F5.3 - - - - - - - 4:39133913-39135608 4 6 6 26 37 34 0.621833520423429 0.847744642800916 0.841029257099519 3.62162208695749 4.71958127261123 4.95384046119565 0.770202473441288 4.43168127358812 -2.52454446517472 1.15943475350861e-07 1.75615246733872e-06 DOWN ENSG00000170122 FOXD4 forkhead box D4 [Source:HGNC Symbol;Acc:HGNC:3805] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0008301|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|DNA binding, bending|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 9:116231-118204 60 64 20 8 7 6 2.15005702114316 2.08428942910864 0.646180871293957 0.256862624546443 0.20580963983975 0.201512152490735 1.62684244051525 0.221394805625643 2.87738125388711 1.16069644398844e-07 1.75717198979873e-06 UP ENSG00000213965 NUDT19 nudix hydrolase 19 [Source:HGNC Symbol;Acc:HGNC:32036] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0043167|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0005102|GO:0043231|GO:0043169|GO:0005737|GO:0046872|GO:0005739|GO:0005777 cell|metabolic process|binding|catalytic activity|intracellular organelle|ion binding|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|receptor binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|metal ion binding|mitochondrion|peroxisome K13355 nucleoside diphosphate-linked moiety X motif 19, mitochondrial [EC:3.6.1.-][-] hsa04146 Peroxisome - Homo sapiens (human) 19:32691961-32713796 1331 1548 919 577 635 494 31.7326520516041 33.5412421021338 19.7541381688644 12.3254134307411 12.42137656436 11.0378322170934 28.3426774408674 11.9282074040648 1.24859880332038 1.18468872097012e-07 1.79258474788859e-06 UP ENSG00000196204 RNF216P1 ring finger protein 216 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:33610] - - - - - - 7:4973988-5040675 288 313 285 144 138 99 1.66985194937345 1.64934065372185 1.48985608249265 0.748075588879014 0.656494928336446 0.537961884704829 1.60301622852932 0.647510800640096 1.30781286842253 1.19200110641653e-07 1.80273561453693e-06 UP ENSG00000230628 RP4-781K5.6 - - - - - - - 1:234669523-234696153 17 11 14 56 57 100 0.337402834060958 0.198426135669931 0.250531068449492 0.995847224904224 0.928212945730852 1.86010682906191 0.262120012726794 1.261388999899 -2.26671384517253 1.19332980951292e-07 1.80383129788348e-06 DOWN ENSG00000153064 BANK1 B-cell scaffold protein with ankyrin repeats 1 [Source:HGNC Symbol;Acc:HGNC:18233] GO:0002376|GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0006807|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0023057|GO:0009893|GO:0009058|GO:0002682|GO:0005515|GO:0019222|GO:0060341|GO:0001818|GO:0006810|GO:0034641|GO:0032940|GO:0031325|GO:0001817|GO:0006413|GO:0001816|GO:0032880|GO:0001775|GO:0009966|GO:0045184|GO:0009890|GO:0010646|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0009968|GO:0002695|GO:0051048|GO:1903531|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0051224|GO:0031324|GO:0031323|GO:0000165|GO:1902533|GO:0051249|GO:0032268|GO:0042113|GO:0010468|GO:0034645|GO:0006518|GO:0032715|GO:0032675|GO:0043412|GO:0032635|GO:0010629|GO:0050709|GO:0006446|GO:0050710|GO:0051223|GO:0015031|GO:0036211|GO:0032269|GO:0070201|GO:0051250|GO:0051046|GO:0009306|GO:0051247|GO:0045947|GO:0050663|GO:0032270|GO:0006796|GO:0043603|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0046903|GO:1902532|GO:0051246|GO:0009059|GO:0050707|GO:1902531|GO:0051896|GO:0043491|GO:0043043|GO:0051898|GO:0031401|GO:0043408|GO:0050869|GO:0017148|GO:0050708|GO:0016310|GO:0010608|GO:0006412|GO:0006417|GO:0050864|GO:0043410|GO:1900165|GO:0006464|GO:0006468|GO:0042325|GO:0001932|GO:0001934|GO:0042327 immune system process|signaling|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|nitrogen compound metabolic process|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of immune system process|protein binding|regulation of metabolic process|regulation of cellular localization|negative regulation of cytokine production|transport|cellular nitrogen compound metabolic process|secretion by cell|positive regulation of cellular metabolic process|regulation of cytokine production|translational initiation|cytokine production|regulation of protein localization|cell activation|regulation of signal transduction|establishment of protein localization|negative regulation of biosynthetic process|regulation of cell communication|protein localization|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|negative regulation of signal transduction|negative regulation of leukocyte activation|negative regulation of secretion|negative regulation of secretion by cell|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|negative regulation of interleukin-6 production|regulation of interleukin-6 production|macromolecule modification|interleukin-6 production|negative regulation of gene expression|negative regulation of protein secretion|regulation of translational initiation|negative regulation of cytokine secretion|regulation of protein transport|protein transport|protein modification process|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|negative regulation of lymphocyte activation|regulation of secretion|protein secretion|positive regulation of protein metabolic process|negative regulation of translational initiation|cytokine secretion|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|secretion|negative regulation of intracellular signal transduction|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of cytokine secretion|regulation of intracellular signal transduction|regulation of protein kinase B signaling|protein kinase B signaling|peptide biosynthetic process|negative regulation of protein kinase B signaling|positive regulation of protein modification process|regulation of MAPK cascade|negative regulation of B cell activation|negative regulation of translation|regulation of protein secretion|phosphorylation|posttranscriptional regulation of gene expression|translation|regulation of translation|regulation of B cell activation|positive regulation of MAPK cascade|negative regulation of interleukin-6 secretion|cellular protein modification process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation - - - - 4:101411286-102074812 19 20 27 69 88 83 0.160263633018076 0.153320539182136 0.205339140202051 0.521478480126578 0.609033557853989 0.656143815150801 0.172974437467421 0.595551951043789 -1.7836685133502 1.19716781244898e-07 1.80871699761397e-06 DOWN ENSG00000137574 TGS1 trimethylguanosine synthase 1 [Source:HGNC Symbol;Acc:HGNC:17843] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0044255|GO:0006725|GO:0006810|GO:1901360|GO:0071166|GO:0034641|GO:0044281|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0030529|GO:0006139|GO:0006629|GO:0051649|GO:0044249|GO:0022613|GO:0031323|GO:0005829|GO:0008168|GO:0010468|GO:0034645|GO:0043412|GO:0051252|GO:0030532|GO:0001510|GO:0046907|GO:0022618|GO:0031981|GO:0005654|GO:0071167|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0034622|GO:0051169|GO:0006396|GO:0032774|GO:0034660|GO:2001141|GO:0009451|GO:0016604|GO:0036261|GO:0016071|GO:0000387|GO:0008173|GO:0006351|GO:0006355|GO:0006913|GO:0015030|GO:1903506|GO:0071164|GO:0006397|GO:0008380|GO:0000375|GO:0051170|GO:0009452|GO:0000398 macromolecular complex|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|methylation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|extracellular space|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular lipid metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|ribonucleoprotein complex localization|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|lipid metabolic process|establishment of localization in cell|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|cytosol|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|regulation of RNA metabolic process|small nuclear ribonucleoprotein complex|RNA methylation|intracellular transport|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|ribonucleoprotein complex import into nucleus|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular macromolecular complex assembly|nuclear transport|RNA processing|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|RNA modification|nuclear body|7-methylguanosine cap hypermethylation|mRNA metabolic process|spliceosomal snRNP assembly|RNA methyltransferase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|Cajal body|regulation of nucleic acid-templated transcription|RNA trimethylguanosine synthase activity|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|nuclear import|7-methylguanosine RNA capping|mRNA splicing, via spliceosome K14292 trimethylguanosine synthase [EC:2.1.1.-][-] hsa03013 RNA transport - Homo sapiens (human) 8:55773142-55825448 831 1047 829 473 522 379 11.1923725512765 12.815859967776 10.0667625217106 5.70794924804762 5.7684553494901 4.78398148361067 11.3583316802544 5.42012869371613 1.06735193437592 1.19844609736701e-07 1.80973241228097e-06 UP ENSG00000169372 CRADD CASP2 and RIPK1 domain containing adaptor with death domain [Source:HGNC Symbol;Acc:HGNC:2340] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0023051|GO:0043227|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0022402|GO:0009612|GO:0010941|GO:0031325|GO:0033554|GO:0010942|GO:0045786|GO:0043231|GO:0019899|GO:0005737|GO:0009966|GO:0030674|GO:0045787|GO:0019904|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0009967|GO:0019538|GO:0031323|GO:2001235|GO:0032268|GO:0000075|GO:0090068|GO:0007166|GO:1903047|GO:0051345|GO:0044770|GO:0051604|GO:0007050|GO:0000278|GO:0070513|GO:0002020|GO:0007346|GO:0010564|GO:0051247|GO:0045930|GO:0006508|GO:0032270|GO:0012501|GO:0035556|GO:0044267|GO:0010467|GO:0051246|GO:0071260|GO:0043068|GO:0072395|GO:0005634|GO:0043067|GO:0006974|GO:0097190|GO:0010948|GO:0043065|GO:0071156|GO:0016485|GO:0007093|GO:0072331|GO:0042770|GO:0044772|GO:0030162|GO:0045862|GO:0044774|GO:0052547|GO:0000077|GO:1901990|GO:0042981|GO:1901987|GO:0010952|GO:0097191|GO:0006915|GO:0044773|GO:1901991|GO:0071158|GO:2000045|GO:0010950|GO:0043281|GO:0044819|GO:0044783|GO:1902806|GO:2000134|GO:0000082|GO:0031638|GO:0043280|GO:0006919|GO:0031571|GO:1902807|GO:0006977|GO:0030330|GO:0008625|GO:0072422|GO:0052548|GO:0072431|GO:2001056|GO:2000116|GO:0097202 signaling|cell|cellular process|metabolic process|response to stimulus|binding|binding, bridging|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|cell cycle process|response to mechanical stimulus|regulation of cell death|positive regulation of cellular metabolic process|cellular response to stress|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of signal transduction|protein binding, bridging|positive regulation of cell cycle|protein domain specific binding|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|positive regulation of signal transduction|protein metabolic process|regulation of cellular metabolic process|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cell cycle checkpoint|positive regulation of cell cycle process|cell surface receptor signaling pathway|mitotic cell cycle process|positive regulation of hydrolase activity|cell cycle phase transition|protein maturation|cell cycle arrest|mitotic cell cycle|death domain binding|protease binding|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|proteolysis|positive regulation of cellular protein metabolic process|programmed cell death|intracellular signal transduction|cellular protein metabolic process|gene expression|regulation of protein metabolic process|cellular response to mechanical stimulus|positive regulation of programmed cell death|signal transduction involved in cell cycle checkpoint|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|negative regulation of cell cycle process|positive regulation of apoptotic process|regulation of cell cycle arrest|protein processing|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|mitotic cell cycle phase transition|regulation of proteolysis|positive regulation of proteolysis|mitotic DNA integrity checkpoint|regulation of peptidase activity|DNA damage checkpoint|regulation of mitotic cell cycle phase transition|regulation of apoptotic process|regulation of cell cycle phase transition|positive regulation of peptidase activity|extrinsic apoptotic signaling pathway|apoptotic process|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|regulation of G1/S transition of mitotic cell cycle|positive regulation of endopeptidase activity|regulation of cysteine-type endopeptidase activity involved in apoptotic process|mitotic G1/S transition checkpoint|G1 DNA damage checkpoint|regulation of cell cycle G1/S phase transition|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|mitotic G1 DNA damage checkpoint|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|extrinsic apoptotic signaling pathway via death domain receptors|signal transduction involved in DNA damage checkpoint|regulation of endopeptidase activity|signal transduction involved in mitotic G1 DNA damage checkpoint|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity - - - - 12:93677375-93894840 14 32 26 94 109 77 0.130119056920669 0.270292164831195 0.217863960525662 0.782762815714929 0.831186454249711 0.670692030592289 0.206091727425842 0.761547100185643 -1.88564667141895 1.19971684020244e-07 1.8107354169567e-06 DOWN ENSG00000070950 RAD18 RAD18, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:18278] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0048523|GO:0051606|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0006281|GO:0032182|GO:0006725|GO:0009314|GO:1901360|GO:0010941|GO:0003676|GO:0034641|GO:0042769|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0043169|GO:0016234|GO:0019899|GO:0005737|GO:0032403|GO:0060548|GO:0006139|GO:0051983|GO:0008219|GO:0019787|GO:0007059|GO:0000151|GO:0051984|GO:0044249|GO:0019538|GO:0003677|GO:0005813|GO:0042405|GO:0034645|GO:0097505|GO:0046872|GO:0043412|GO:0004842|GO:0043130|GO:0019985|GO:0005815|GO:0016818|GO:0036211|GO:0005657|GO:0035861|GO:0031981|GO:1990234|GO:0005654|GO:0006259|GO:0005694|GO:0006301|GO:0044267|GO:0009059|GO:0005856|GO:0005634|GO:0009416|GO:0006974|GO:0044389|GO:0031625|GO:0061630|GO:0009411|GO:0043566|GO:0003684|GO:0015630|GO:0046914|GO:0031593|GO:0006464|GO:0016462|GO:0071897|GO:0017111|GO:0008270|GO:0032446|GO:0016887|GO:0000403|GO:0042623|GO:0016567|GO:0006513|GO:0008094|GO:0043142 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|detection of stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|ligase activity|intracellular|protein binding|protein complex|transferase activity|DNA repair|ubiquitin-like protein binding|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|regulation of cell death|nucleic acid binding|cellular nitrogen compound metabolic process|DNA damage response, detection of DNA damage|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|inclusion body|enzyme binding|cytoplasm|protein complex binding|negative regulation of cell death|nucleobase-containing compound metabolic process|regulation of chromosome segregation|cell death|ubiquitin-like protein transferase activity|chromosome segregation|ubiquitin ligase complex|positive regulation of chromosome segregation|cellular biosynthetic process|protein metabolic process|DNA binding|centrosome|nuclear inclusion body|cellular macromolecule biosynthetic process|Rad6-Rad18 complex|metal ion binding|macromolecule modification|ubiquitin-protein transferase activity|ubiquitin binding|translesion synthesis|microtubule organizing center|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|replication fork|site of double-strand break|nuclear lumen|transferase complex|nucleoplasm|DNA metabolic process|chromosome|postreplication repair|cellular protein metabolic process|macromolecule biosynthetic process|cytoskeleton|nucleus|response to light stimulus|cellular response to DNA damage stimulus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|ubiquitin protein ligase activity|response to UV|structure-specific DNA binding|damaged DNA binding|microtubule cytoskeleton|transition metal ion binding|polyubiquitin binding|cellular protein modification process|pyrophosphatase activity|DNA biosynthetic process|nucleoside-triphosphatase activity|zinc ion binding|protein modification by small protein conjugation|ATPase activity|Y-form DNA binding|ATPase activity, coupled|protein ubiquitination|protein monoubiquitination|DNA-dependent ATPase activity|single-stranded DNA-dependent ATPase activity - - - - 3:8775402-8963773 283 325 422 808 1030 687 2.25003474183317 2.34836502195745 3.02502758897108 5.75587250922752 6.71904220894196 5.11903101396818 2.54114245092057 5.86464857737922 -1.20656740938368 1.20324494774034e-07 1.81514273217989e-06 DOWN ENSG00000020426 MNAT1 MNAT CDK-activating kinase assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:7181] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0016032|GO:0007507|GO:0047485|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0034641|GO:0016772|GO:0048524|GO:0031325|GO:0046483|GO:0033554|GO:0016817|GO:0007420|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0060322|GO:0005667|GO:0060548|GO:0006139|GO:0008219|GO:0050790|GO:0010035|GO:0044249|GO:0019538|GO:0050792|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0048660|GO:0046872|GO:1903047|GO:0044798|GO:0043412|GO:0072358|GO:0007417|GO:0010629|GO:0043069|GO:0051252|GO:0044770|GO:0048659|GO:0010628|GO:0010038|GO:0048661|GO:0016818|GO:0036211|GO:0000278|GO:0019083|GO:0031981|GO:1990234|GO:0005654|GO:0006259|GO:0006461|GO:0016301|GO:0012501|GO:0006796|GO:0044267|GO:1903902|GO:0051174|GO:0021591|GO:0010467|GO:0007399|GO:0019058|GO:0007512|GO:0031328|GO:0051246|GO:0009059|GO:0006289|GO:0016070|GO:0072359|GO:0016773|GO:0010557|GO:0005634|GO:0043067|GO:0006974|GO:0045814|GO:0045893|GO:0006396|GO:0000086|GO:0046782|GO:0032774|GO:0044772|GO:0051592|GO:2001141|GO:0005675|GO:0016310|GO:0006283|GO:0040029|GO:0070911|GO:0016071|GO:0042981|GO:0046914|GO:0043066|GO:0004672|GO:0090575|GO:0050434|GO:0006464|GO:0016591|GO:0016462|GO:0000079|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0045859|GO:0006352|GO:0006357|GO:1902911|GO:0006360|GO:0006468|GO:1903506|GO:0017111|GO:0042325|GO:0006354|GO:0001932|GO:0006397|GO:0000082|GO:0004674|GO:0006353|GO:0008270|GO:0006367|GO:0016887|GO:0006368|GO:1902554|GO:0006361|GO:0006370|GO:0006362|GO:0006363|GO:0008353|GO:0071900|GO:0009452|GO:0042623|GO:0008094 developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|viral process|heart development|protein N-terminus binding|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|brain development|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|head development|transcription factor complex|negative regulation of cell death|nucleobase-containing compound metabolic process|cell death|regulation of catalytic activity|response to inorganic substance|cellular biosynthetic process|protein metabolic process|regulation of viral process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|metal ion binding|mitotic cell cycle process|nuclear transcription factor complex|macromolecule modification|cardiovascular system development|central nervous system development|negative regulation of gene expression|negative regulation of programmed cell death|regulation of RNA metabolic process|cell cycle phase transition|smooth muscle cell proliferation|positive regulation of gene expression|response to metal ion|positive regulation of smooth muscle cell proliferation|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|mitotic cell cycle|viral transcription|nuclear lumen|transferase complex|nucleoplasm|DNA metabolic process|protein complex assembly|kinase activity|programmed cell death|phosphate-containing compound metabolic process|cellular protein metabolic process|positive regulation of viral life cycle|regulation of phosphorus metabolic process|ventricular system development|gene expression|nervous system development|viral life cycle|adult heart development|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|nucleotide-excision repair|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|negative regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|RNA processing|G2/M transition of mitotic cell cycle|regulation of viral transcription|RNA biosynthetic process|mitotic cell cycle phase transition|response to calcium ion|regulation of RNA biosynthetic process|holo TFIIH complex|phosphorylation|transcription-coupled nucleotide-excision repair|regulation of gene expression, epigenetic|global genome nucleotide-excision repair|mRNA metabolic process|regulation of apoptotic process|transition metal ion binding|negative regulation of apoptotic process|protein kinase activity|RNA polymerase II transcription factor complex|positive regulation of viral transcription|cellular protein modification process|DNA-directed RNA polymerase II, holoenzyme|pyrophosphatase activity|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of protein kinase activity|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|protein kinase complex|transcription from RNA polymerase I promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|regulation of phosphorylation|DNA-templated transcription, elongation|regulation of protein phosphorylation|mRNA processing|G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|DNA-templated transcription, termination|zinc ion binding|transcription initiation from RNA polymerase II promoter|ATPase activity|transcription elongation from RNA polymerase II promoter|serine/threonine protein kinase complex|transcription initiation from RNA polymerase I promoter|7-methylguanosine mRNA capping|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|RNA polymerase II carboxy-terminal domain kinase activity|regulation of protein serine/threonine kinase activity|7-methylguanosine RNA capping|ATPase activity, coupled|DNA-dependent ATPase activity K10842 CDK-activating kinase assembly factor MAT1[-] hsa03420|hsa03022 Nucleotide excision repair - Homo sapiens (human)|Basal transcription factors - Homo sapiens (human) 14:60734742-60969953 291 279 470 838 930 792 3.47006534080834 3.023632451908 5.05308217434432 8.95336466193362 9.09903826576627 8.85112413974041 3.84892665568689 8.96784235581343 -1.22030473774741 1.20742816987095e-07 1.82053336279431e-06 DOWN ENSG00000184949 FAM227A family with sequence similarity 227 member A [Source:HGNC Symbol;Acc:HGNC:44197] - - - - - - 22:38578120-38656629 50 60 65 174 157 219 0.252143057625012 0.274986677460909 0.295535271779837 0.786189751501887 0.649602515079195 1.03503326963932 0.274221668955253 0.823608512073467 -1.58661616327187 1.20974029045162e-07 1.82217894203546e-06 DOWN ENSG00000275066 SYNRG synergin, gamma [Source:HGNC Symbol;Acc:HGNC:557] GO:0032991|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0030119|GO:0006810|GO:0030660|GO:0031982|GO:0030117|GO:0043231|GO:0030133|GO:0005737|GO:0012506|GO:0045184|GO:0030658|GO:0008104|GO:0051649|GO:0005794|GO:0016192|GO:0005798|GO:0030121|GO:0031410|GO:0030131|GO:0030130|GO:0015031|GO:0016023|GO:0030665|GO:0012510|GO:0046907|GO:0031988|GO:0034613|GO:0030118|GO:0030659|GO:0030140|GO:0000139|GO:0030120|GO:0030125|GO:0006886|GO:0030135|GO:0006897|GO:0030136 macromolecular complex|cell|membrane|binding|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|AP-type membrane coat adaptor complex|transport|Golgi-associated vesicle membrane|vesicle|membrane coat|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|vesicle membrane|establishment of protein localization|transport vesicle membrane|protein localization|establishment of localization in cell|Golgi apparatus|vesicle-mediated transport|Golgi-associated vesicle|AP-1 adaptor complex|cytoplasmic vesicle|clathrin adaptor complex|clathrin coat of trans-Golgi network vesicle|protein transport|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|trans-Golgi network transport vesicle membrane|intracellular transport|membrane-bounded vesicle|cellular protein localization|clathrin coat|cytoplasmic vesicle membrane|trans-Golgi network transport vesicle|Golgi membrane|vesicle coat|clathrin vesicle coat|intracellular protein transport|coated vesicle|endocytosis|clathrin-coated vesicle - - - - 17:37514797-37609496 131 206 256 486 533 579 0.441179177412753 0.630507723685408 0.77731769286975 1.46648583486617 1.47278291716841 1.82747294385479 0.61633486465597 1.58891389862979 -1.36625464037004 1.20941317011984e-07 1.82217894203546e-06 DOWN ENSG00000103479 RBL2 retinoblastoma-like 2 [Source:HGNC Symbol;Acc:HGNC:9894] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0005667|GO:0006139|GO:0006629|GO:0070062|GO:0050790|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0006325|GO:0000278|GO:0031981|GO:0005654|GO:0006796|GO:0051174|GO:0010467|GO:0019216|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043550|GO:2001141|GO:0016310|GO:0016568|GO:0043549|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0042325 macromolecular complex|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|transcription factor complex|nucleobase-containing compound metabolic process|lipid metabolic process|extracellular exosome|regulation of catalytic activity|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|chromatin organization|mitotic cell cycle|nuclear lumen|nucleoplasm|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of lipid metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of lipid kinase activity|regulation of RNA biosynthetic process|phosphorylation|chromatin modification|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|regulation of phosphorylation K16332 retinoblastoma-like protein 2[-] hsa04151|hsa05203|hsa04068|hsa04110 PI3K-Akt signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Cell cycle - Homo sapiens (human) 16:53433977-53491649 699 806 1724 2675 3101 4001 4.23766253886736 4.4408318756467 9.42325089673666 14.5301715926727 15.4247823530642 22.7324778164587 6.03391510375024 17.5624772540652 -1.54133005359257 1.21854887073067e-07 1.8345213306502e-06 DOWN ENSG00000196458 ZNF605 zinc finger protein 605 [Source:HGNC Symbol;Acc:HGNC:28068] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 12:132918308-132956306 20 39 10 168 87 223 0.0804376574887536 0.142553741513622 0.0362622538075469 0.60538995500773 0.287087342994041 0.84054779706286 0.0864178842699742 0.57767503168821 -2.74085632413508 1.2312615551398e-07 1.8527259308036e-06 DOWN ENSG00000118997 DNAH7 dynein, axonemal, heavy chain 7 [Source:HGNC Symbol;Acc:HGNC:18661] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0043229|GO:0043167|GO:0048870|GO:0009653|GO:0016043|GO:0016787|GO:0005622|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0001539|GO:0005930|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0022607|GO:0043169|GO:0005737|GO:0006928|GO:0005875|GO:0000166|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0005858|GO:0046872|GO:0070286|GO:0035639|GO:0007010|GO:0001883|GO:0035082|GO:0016818|GO:0044782|GO:0032549|GO:0030031|GO:0007018|GO:0030286|GO:0006461|GO:0070925|GO:0042384|GO:0032990|GO:0017076|GO:0048858|GO:0000226|GO:0005856|GO:0060271|GO:0036159|GO:0034622|GO:0005524|GO:0043623|GO:0030554|GO:0005509|GO:0015630|GO:0001578|GO:0036156|GO:0016462|GO:0003341|GO:0017111|GO:0016887|GO:0003774|GO:0003777 locomotion|developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|intracellular organelle|ion binding|cell motility|anatomical structure morphogenesis|cellular component organization|hydrolase activity|intracellular|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|cilium or flagellum-dependent cell motility|axoneme|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|cellular component assembly|cation binding|cytoplasm|movement of cell or subcellular component|microtubule associated complex|nucleotide binding|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|axonemal dynein complex|metal ion binding|axonemal dynein complex assembly|purine ribonucleoside triphosphate binding|cytoskeleton organization|purine nucleoside binding|axoneme assembly|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cilium organization|ribonucleoside binding|cell projection assembly|microtubule-based movement|dynein complex|protein complex assembly|organelle assembly|cilium assembly|cell part morphogenesis|purine nucleotide binding|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|cilium morphogenesis|inner dynein arm assembly|cellular macromolecular complex assembly|ATP binding|cellular protein complex assembly|adenyl nucleotide binding|calcium ion binding|microtubule cytoskeleton|microtubule bundle formation|inner dynein arm|pyrophosphatase activity|cilium movement|nucleoside-triphosphatase activity|ATPase activity|motor activity|microtubule motor activity K10408 dynein heavy chain, axonemal[-] hsa05016 Huntington,s disease - Homo sapiens (human) 2:195737703-196068812 9 7 16 52 46 53 0.0279409785827489 0.0197516585126775 0.0447859921855351 0.144642356775568 0.11717121096781 0.154205293198221 0.0308262097603205 0.1386729536472 -2.1694570174769 1.23521421390759e-07 1.85773728675049e-06 DOWN ENSG00000163946 FAM208A family with sequence similarity 208 member A [Source:HGNC Symbol;Acc:HGNC:30314] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0003723|GO:0051252|GO:0005694|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0044822|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|regulation of RNA metabolic process|chromosome|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 3:56620133-56683237 530 747 704 1503 1559 1504 1.94110547515786 2.48641948467632 2.32466676419555 4.93207950183102 4.6847630867517 5.16238547321422 2.25073057467658 4.92640935393231 -1.13014314351007 1.23930975233007e-07 1.86108417233711e-06 DOWN ENSG00000164576 SAP30L SAP30-like [Source:HGNC Symbol;Acc:HGNC:25663] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0006325|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045814|GO:0032774|GO:2001141|GO:0040029|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of gene expression, epigenetic|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 5:154445957-154461054 1397 1456 1360 685 857 700 10.860467367242 10.2871121580126 9.53246304775286 4.77134205691952 5.46638983851904 5.10010711668161 10.2266808576692 5.11261300404006 1.00020525267445 1.23841957304375e-07 1.86108417233711e-06 UP ENSG00000196872 KIAA1211L KIAA1211-like [Source:HGNC Symbol;Acc:HGNC:33454] - - - - - - 2:98793846-98936259 556 603 661 303 358 293 4.90640173474911 4.8359872228464 5.25900586601684 2.39567428875305 2.59202654534212 2.42317758008177 5.00046494120412 2.47029280472565 1.0173801871988 1.23907633444391e-07 1.86108417233711e-06 UP ENSG00000128908 INO80 INO80 complex subunit [Source:HGNC Symbol;Acc:HGNC:26956] GO:0040007|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0000785|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0009314|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0030307|GO:0005874|GO:0001882|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0016817|GO:0022607|GO:0070603|GO:0043231|GO:0045787|GO:0006139|GO:0000790|GO:0008092|GO:0007059|GO:0000166|GO:0051301|GO:0044249|GO:0007017|GO:0001558|GO:0031323|GO:0006996|GO:0051276|GO:0015631|GO:0003677|GO:0000819|GO:0010468|GO:0034645|GO:0090068|GO:0000725|GO:0035639|GO:1903047|GO:0007010|GO:0051252|GO:0006325|GO:0001883|GO:0003779|GO:0044770|GO:0010628|GO:0006302|GO:0016818|GO:0033260|GO:0000278|GO:0032549|GO:0031011|GO:0031981|GO:0007346|GO:0010564|GO:0071478|GO:0006259|GO:0007051|GO:0005694|GO:0000228|GO:0006461|GO:0070925|GO:0051054|GO:0010212|GO:0007067|GO:0010467|GO:0017076|GO:0031328|GO:0009059|GO:0016070|GO:0000226|GO:0005856|GO:0010557|GO:0005634|GO:0009416|GO:0070914|GO:0006974|GO:0051225|GO:0000724|GO:0045893|GO:0033262|GO:0006260|GO:0009411|GO:0032774|GO:0005524|GO:0044772|GO:2001141|GO:0030554|GO:1901990|GO:0043014|GO:0015630|GO:0071482|GO:0006275|GO:0006310|GO:0000070|GO:0016568|GO:1901987|GO:0071479|GO:0045740|GO:0010571|GO:0071103|GO:0016462|GO:0006351|GO:0006355|GO:0045944|GO:2000045|GO:0006366|GO:0006357|GO:0006261|GO:0032392|GO:1903506|GO:0017111|GO:1902806|GO:0000082|GO:2000105|GO:0006338|GO:0034644|GO:0016887|GO:0032508|GO:0004386|GO:0003678 growth|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|chromatin|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|response to radiation|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|positive regulation of cell growth|microtubule|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|hydrolase activity, acting on acid anhydrides|cellular component assembly|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|positive regulation of cell cycle|nucleobase-containing compound metabolic process|nuclear chromatin|cytoskeletal protein binding|chromosome segregation|nucleotide binding|cell division|cellular biosynthetic process|microtubule-based process|regulation of cell growth|regulation of cellular metabolic process|organelle organization|chromosome organization|tubulin binding|DNA binding|sister chromatid segregation|regulation of gene expression|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|recombinational repair|purine ribonucleoside triphosphate binding|mitotic cell cycle process|cytoskeleton organization|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|actin binding|cell cycle phase transition|positive regulation of gene expression|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nuclear DNA replication|mitotic cell cycle|ribonucleoside binding|Ino80 complex|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|cellular response to radiation|DNA metabolic process|spindle organization|chromosome|nuclear chromosome|protein complex assembly|organelle assembly|positive regulation of DNA metabolic process|response to ionizing radiation|mitotic nuclear division|gene expression|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|microtubule cytoskeleton organization|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|UV-damage excision repair|cellular response to DNA damage stimulus|spindle assembly|double-strand break repair via homologous recombination|positive regulation of transcription, DNA-templated|regulation of nuclear cell cycle DNA replication|DNA replication|response to UV|RNA biosynthetic process|ATP binding|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|adenyl nucleotide binding|regulation of mitotic cell cycle phase transition|alpha-tubulin binding|microtubule cytoskeleton|cellular response to light stimulus|regulation of DNA replication|DNA recombination|mitotic sister chromatid segregation|chromatin modification|regulation of cell cycle phase transition|cellular response to ionizing radiation|positive regulation of DNA replication|positive regulation of nuclear cell cycle DNA replication|DNA conformation change|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication|DNA geometric change|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|regulation of cell cycle G1/S phase transition|G1/S transition of mitotic cell cycle|positive regulation of DNA-dependent DNA replication|chromatin remodeling|cellular response to UV|ATPase activity|DNA duplex unwinding|helicase activity|DNA helicase activity - - - - 15:40978880-41116354 270 308 244 711 828 600 1.6639591730563 1.72508181219319 1.35576269359433 3.92596963107479 4.18675754646059 3.46545163930209 1.58160122628127 3.85939293894582 -1.28698804266731 1.24564751805908e-07 1.86872165849929e-06 DOWN ENSG00000278238 RP11-245D16.4 - - - - - - - 13:52454775-52455331 17 29 19 2 5 2 2.1588935378694 3.34714934461559 2.17549302290967 0.227579363040699 0.521005197888502 0.238009857729688 2.56051196846489 0.32886480621963 2.9608657724522 1.24507910132139e-07 1.86872165849929e-06 UP ENSG00000141026 MED9 mediator complex subunit 9 [Source:HGNC Symbol;Acc:HGNC:25487] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0016592|GO:0001076|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0001104|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|mediator complex|transcription factor activity, RNA polymerase II transcription factor binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|RNA polymerase II transcription cofactor activity|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 17:17476986-17493226 548 639 584 295 325 292 5.24472757965291 5.55805932257925 5.0392975090148 2.52966342795316 2.55207847058096 2.61910908128905 5.28069480374899 2.56695032660772 1.04067238526746 1.2507242296438e-07 1.87539533660402e-06 UP ENSG00000120053 GOT1 glutamic-oxaloacetic transaminase 1, soluble [Source:HGNC Symbol;Acc:HGNC:4432] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0042802|GO:0016830|GO:0044262|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0031982|GO:0043231|GO:0010243|GO:0005737|GO:0006520|GO:0005975|GO:0042592|GO:0043177|GO:0043005|GO:0007154|GO:0007165|GO:0070062|GO:0030170|GO:0009725|GO:0044306|GO:0044249|GO:0010033|GO:0006790|GO:0005829|GO:0007166|GO:0033993|GO:0030424|GO:0048878|GO:0006066|GO:0009308|GO:1901652|GO:0005773|GO:0071417|GO:0008483|GO:0006071|GO:0000096|GO:0043679|GO:0009063|GO:0043434|GO:0005996|GO:0016831|GO:0008652|GO:0014070|GO:0031406|GO:0071310|GO:0032870|GO:0005634|GO:0016051|GO:0048545|GO:0019318|GO:1901653|GO:0000323|GO:0004069|GO:0047801|GO:0006114|GO:0046395|GO:0004609|GO:0006576|GO:0071375|GO:0050801|GO:0019752|GO:0032868|GO:0055088|GO:0006555|GO:0007219|GO:0031960|GO:0000097|GO:0006531|GO:0051384|GO:0019319|GO:0043648|GO:0005764|GO:0009086|GO:0071267|GO:0006006|GO:0055081|GO:0032869|GO:0055089|GO:0080130|GO:0043649|GO:0006595|GO:0006536|GO:0006107|GO:0006538|GO:0006103|GO:0006106|GO:0006094|GO:0019509|GO:0019550|GO:0006532|GO:0006533|GO:0019551 signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|biosynthetic process|intracellular|protein binding|transferase activity|identical protein binding|carbon-carbon lyase activity|cellular carbohydrate metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|carbohydrate metabolic process|homeostatic process|organic acid binding|neuron projection|cell communication|signal transduction|extracellular exosome|pyridoxal phosphate binding|response to hormone|neuron projection terminus|cellular biosynthetic process|response to organic substance|sulfur compound metabolic process|cytosol|cell surface receptor signaling pathway|response to lipid|axon|chemical homeostasis|alcohol metabolic process|amine metabolic process|response to peptide|vacuole|cellular response to organonitrogen compound|transaminase activity|glycerol metabolic process|sulfur amino acid metabolic process|axon terminus|cellular amino acid catabolic process|response to peptide hormone|monosaccharide metabolic process|carboxy-lyase activity|cellular amino acid biosynthetic process|response to organic cyclic compound|carboxylic acid binding|cellular response to organic substance|cellular response to hormone stimulus|nucleus|carbohydrate biosynthetic process|response to steroid hormone|hexose metabolic process|cellular response to peptide|lytic vacuole|L-aspartate:2-oxoglutarate aminotransferase activity|L-cysteine:2-oxoglutarate aminotransferase activity|glycerol biosynthetic process|carboxylic acid catabolic process|phosphatidylserine decarboxylase activity|cellular biogenic amine metabolic process|cellular response to peptide hormone stimulus|ion homeostasis|carboxylic acid metabolic process|response to insulin|lipid homeostasis|methionine metabolic process|Notch signaling pathway|response to corticosteroid|sulfur amino acid biosynthetic process|aspartate metabolic process|response to glucocorticoid|hexose biosynthetic process|dicarboxylic acid metabolic process|lysosome|methionine biosynthetic process|L-methionine salvage|glucose metabolic process|anion homeostasis|cellular response to insulin stimulus|fatty acid homeostasis|L-phenylalanine:2-oxoglutarate aminotransferase activity|dicarboxylic acid catabolic process|polyamine metabolic process|glutamate metabolic process|oxaloacetate metabolic process|glutamate catabolic process|2-oxoglutarate metabolic process|fumarate metabolic process|gluconeogenesis|L-methionine biosynthetic process from methylthioadenosine|glutamate catabolic process to aspartate|aspartate biosynthetic process|aspartate catabolic process|glutamate catabolic process to 2-oxoglutarate K14454 aspartate aminotransferase, cytoplasmic[2.6.1.1] hsa01100|hsa01200|hsa01230|hsa00330|hsa00270|hsa00250|hsa00350|hsa00220|hsa01210|hsa00360|hsa00400 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Arginine and proline metabolism - Homo sapiens (human)|Cysteine and methionine metabolism - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human)|Tyrosine metabolism - Homo sapiens (human)|Arginine biosynthesis - Homo sapiens (human)|2-Oxocarboxylic acid metabolism - Homo sapiens (human)|Phenylalanine metabolism - Homo sapiens (human)|Phenylalanine, tyrosine and tryptophan biosynthesis - Homo sapiens (human) 10:99396870-99430624 393 419 544 1106 1125 893 8.78066403257498 8.50802589885912 10.9584099208022 22.1405087205665 20.6231655648022 18.6988549845529 9.41569995074543 20.4875097566405 -1.12160438438091 1.25932658763634e-07 1.88734618209314e-06 DOWN ENSG00000204634 TBC1D8 TBC1 domain family member 8 [Source:HGNC Symbol;Acc:HGNC:17791] GO:0016020|GO:0009987|GO:0008152|GO:0008283|GO:0050794|GO:0009893|GO:0030234|GO:0019222|GO:0008284|GO:0042127|GO:0008047|GO:0043085|GO:0050790|GO:0003013|GO:0005096|GO:0051345|GO:0030695|GO:0008015|GO:0043087|GO:0043547 membrane|cellular process|metabolic process|cell proliferation|regulation of cellular process|positive regulation of metabolic process|enzyme regulator activity|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|enzyme activator activity|positive regulation of catalytic activity|regulation of catalytic activity|circulatory system process|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|blood circulation|regulation of GTPase activity|positive regulation of GTPase activity - - - - 2:101007617-101252866 256 302 639 1050 1130 1248 2.32490095096494 2.49258765282822 5.23214027813801 8.54379908842661 8.41996945350979 10.622028013057 3.34987629397706 9.19526551833113 -1.4567834139084 1.26712139287219e-07 1.89807536692455e-06 DOWN ENSG00000111011 RSRC2 arginine/serine-rich coiled-coil 2 [Source:HGNC Symbol;Acc:HGNC:30559] GO:0005488|GO:0097159|GO:0005515|GO:0003676|GO:0003723|GO:0044822 binding|organic cyclic compound binding|protein binding|nucleic acid binding|RNA binding|poly(A) RNA binding - - - - 12:122503458-122527000 2244 2111 2070 1091 1318 902 9.43999228195124 8.07080861208475 7.85115453268845 4.11217186317675 4.54917163425408 3.55618299769517 8.45398514224148 4.07250883170867 1.0537137494489 1.26797205952871e-07 1.89839708451205e-06 UP ENSG00000198040 ZNF84 zinc finger protein 84 [Source:HGNC Symbol;Acc:HGNC:13159] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0008270 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 12:133037292-133063304 727 738 236 154 157 151 2.00209136447679 1.84707972372767 0.585969780468035 0.379986401556969 0.354744782333406 0.389722683700952 1.4783802895575 0.374817955863776 1.97975545444646 1.27233660144007e-07 1.90397678693694e-06 UP ENSG00000273036 FAM95C family with sequence similarity 95 member C [Source:HGNC Symbol;Acc:HGNC:45272] - - - - - - 9:38540567-38545372 47 65 47 7 10 20 0.947461701606156 1.19085353656238 0.854222947083194 0.126427446321408 0.165403189070331 0.377844383315807 0.997512728417243 0.223225006235849 2.15983659985851 1.27712178094904e-07 1.91018004250764e-06 UP ENSG00000075413 MARK3 MAP/microtubule affinity-regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0006935|GO:0045087|GO:0048468|GO:0007275|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0010243|GO:0005737|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0070062|GO:0009725|GO:0050790|GO:0000166|GO:0030030|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007166|GO:0035639|GO:0043412|GO:0001883|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0032549|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0016301|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0017076|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0016773|GO:0032870|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:1901653|GO:0043408|GO:0005524|GO:0071363|GO:0030554|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0007167|GO:0071375|GO:0043410|GO:0004672|GO:0032868|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0004674|GO:0001934|GO:0042327|GO:0007169|GO:0048010|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|intracellular|regulation of immune system process|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|chemotaxis|innate immune response|cell development|multicellular organism development|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|response to organonitrogen compound|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|extracellular exosome|response to hormone|regulation of catalytic activity|nucleotide binding|cell projection organization|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|ribonucleoside binding|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|kinase activity|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular response to peptide|regulation of MAPK cascade|ATP binding|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|protein kinase activity|response to insulin|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 14:103385392-103503831 891 978 1294 2218 2559 2356 3.28502831226108 3.27702711782788 4.30140015305054 7.32690432264505 7.74104511312856 8.14077034121315 3.6211518610465 7.73623992566225 -1.09518385741442 1.29224706733822e-07 1.93183494984053e-06 DOWN ENSG00000206129 CTD-2008L17.2 - - - - - - - 18:56003613-56191262 2 5 2 28 33 18 0.0454439851899551 0.10326596050537 0.0409752984238442 0.570060955598884 0.61524985910651 0.38332298435584 0.0632284147063898 0.522877933020411 -3.0478292323898 1.30909688311611e-07 1.9560449623898e-06 DOWN ENSG00000095319 NUP188 nucleoporin 188kDa [Source:HGNC Symbol;Acc:HGNC:17859] GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0017056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0012505|GO:0019222|GO:0016032|GO:0007049|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0034641|GO:0044281|GO:0046483|GO:0033554|GO:0043231|GO:0044611|GO:0009408|GO:0005975|GO:0005635|GO:0045184|GO:0016458|GO:0006139|GO:0008104|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0051649|GO:0006403|GO:0044249|GO:0009266|GO:0019538|GO:0010033|GO:0010256|GO:0006996|GO:0051701|GO:1900034|GO:0019048|GO:0006998|GO:0010468|GO:0019054|GO:0007166|GO:1903047|GO:0043412|GO:0072594|GO:0034097|GO:0031047|GO:0010629|GO:0015031|GO:0036211|GO:0000278|GO:0046907|GO:0019083|GO:0034605|GO:0034613|GO:0050658|GO:0044267|GO:0010467|GO:0017038|GO:0019058|GO:0071310|GO:0006997|GO:0009059|GO:0016070|GO:0008643|GO:0005634|GO:0006606|GO:0005643|GO:0010827|GO:0007077|GO:0019221|GO:0033365|GO:0051028|GO:0051169|GO:0006396|GO:0032774|GO:0034660|GO:0006605|GO:0006886|GO:0051081|GO:0071345|GO:0006464|GO:0006405|GO:0006913|GO:0008645|GO:0006399|GO:0018193|GO:0043687|GO:0034504|GO:0008033|GO:0032446|GO:0051170|GO:0051168|GO:0015758|GO:0018205|GO:0016925 macromolecular complex|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|structural constituent of nuclear pore|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|endomembrane system|regulation of metabolic process|viral process|cell cycle|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|nuclear pore inner ring|response to heat|carbohydrate metabolic process|nuclear envelope|establishment of protein localization|gene silencing|nucleobase-containing compound metabolic process|protein localization|cell communication|transmembrane transport|membrane organization|signal transduction|establishment of localization in cell|RNA localization|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|response to organic substance|endomembrane system organization|organelle organization|interaction with host|regulation of cellular response to heat|modulation by virus of host morphology or physiology|nuclear envelope organization|regulation of gene expression|modulation by virus of host process|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|establishment of protein localization to organelle|response to cytokine|gene silencing by RNA|negative regulation of gene expression|protein transport|protein modification process|mitotic cell cycle|intracellular transport|viral transcription|cellular response to heat|cellular protein localization|RNA transport|cellular protein metabolic process|gene expression|protein import|viral life cycle|cellular response to organic substance|nucleus organization|macromolecule biosynthetic process|RNA metabolic process|carbohydrate transport|nucleus|protein import into nucleus|nuclear pore|regulation of glucose transport|mitotic nuclear envelope disassembly|cytokine-mediated signaling pathway|protein localization to organelle|mRNA transport|nuclear transport|RNA processing|RNA biosynthetic process|ncRNA metabolic process|protein targeting|intracellular protein transport|nuclear envelope disassembly|cellular response to cytokine stimulus|cellular protein modification process|RNA export from nucleus|nucleocytoplasmic transport|hexose transport|tRNA metabolic process|peptidyl-amino acid modification|post-translational protein modification|protein localization to nucleus|tRNA processing|protein modification by small protein conjugation|nuclear import|nuclear export|glucose transport|peptidyl-lysine modification|protein sumoylation K14311 nuclear pore complex protein Nup188[-] hsa03013 RNA transport - Homo sapiens (human) 9:128947699-129007096 4260 4578 3502 2068 2343 1434 30.3891715893858 29.6800760401245 22.523692112315 13.2177469780459 13.7135376833113 9.58709925398 27.5309799139418 12.1727946384457 1.17739553990639 1.3163331018901e-07 1.96565173004106e-06 UP ENSG00000259209 RP5-991G20.2 - - - - - - - 16:72805998-72809872 0 0 1 11 11 15 0 0 0.0298150972029207 0.326079195308306 0.298599109767638 0.46512030597127 0.0099383657343069 0.363266203682405 -5.19187470685067 1.31684312322708e-07 1.96565173004106e-06 DOWN ENSG00000136824 SMC2 structural maintenance of chromosomes 2 [Source:HGNC Symbol;Acc:HGNC:14011] GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0005488|GO:0036094|GO:1903561|GO:0097159|GO:0043229|GO:0044702|GO:0051321|GO:0043167|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0022402|GO:0043168|GO:0001882|GO:0031982|GO:0043231|GO:0005737|GO:0046983|GO:0010032|GO:0070192|GO:0007126|GO:0070062|GO:0007059|GO:0000166|GO:0051301|GO:0006996|GO:0051276|GO:0005730|GO:0005829|GO:0000819|GO:0035639|GO:1903047|GO:0046982|GO:0001883|GO:0000278|GO:0032549|GO:0031981|GO:0045132|GO:0005654|GO:0005694|GO:0000228|GO:0007067|GO:0017076|GO:0005634|GO:0030261|GO:0000796|GO:0051383|GO:0000793|GO:0005524|GO:0030554|GO:0007076|GO:0000070|GO:0071103|GO:0006323 macromolecular complex|reproduction|cell|cellular process|extracellular region|reproductive process|binding|small molecule binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|single organism reproductive process|meiotic cell cycle|ion binding|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|cell cycle process|anion binding|nucleoside binding|vesicle|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|meiotic chromosome condensation|chromosome organization involved in meiotic cell cycle|meiotic nuclear division|extracellular exosome|chromosome segregation|nucleotide binding|cell division|organelle organization|chromosome organization|nucleolus|cytosol|sister chromatid segregation|purine ribonucleoside triphosphate binding|mitotic cell cycle process|protein heterodimerization activity|purine nucleoside binding|mitotic cell cycle|ribonucleoside binding|nuclear lumen|meiotic chromosome segregation|nucleoplasm|chromosome|nuclear chromosome|mitotic nuclear division|purine nucleotide binding|nucleus|chromosome condensation|condensin complex|kinetochore organization|condensed chromosome|ATP binding|adenyl nucleotide binding|mitotic chromosome condensation|mitotic sister chromatid segregation|DNA conformation change|DNA packaging - - - - 9:104094260-104141417 674 761 838 1901 2033 1427 4.59577868116222 4.71589822210772 5.15178386907822 11.6139318776873 11.3737776417943 9.11910598304137 4.82115359078272 10.7022718341743 -1.15046678199526 1.31844563740886e-07 1.9670602728238e-06 DOWN ENSG00000170634 ACYP2 acylphosphatase 2, muscle type [Source:HGNC Symbol;Acc:HGNC:180] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0016817|GO:0043231|GO:0005737|GO:0016818|GO:0005739|GO:0006796|GO:0003998 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitochondrion|phosphate-containing compound metabolic process|acylphosphatase activity K01512 acylphosphatase[3.6.1.7] hsa00620 Pyruvate metabolism - Homo sapiens (human) 2:53970838-54305300 31 40 44 143 113 120 0.308503072990499 0.361774350473098 0.394790030880931 1.27506659972189 0.922664148977785 1.11920043329091 0.355022484781509 1.10564372733019 -1.63890427600124 1.32202916026685e-07 1.9714215060243e-06 DOWN ENSG00000149658 YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:15867] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0044877|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009893|GO:0009058|GO:0005622|GO:0019222|GO:0003676|GO:0043021|GO:0034641|GO:0031325|GO:0006413|GO:0005737|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0006446|GO:0010628|GO:0051247|GO:0043022|GO:0032270|GO:0043603|GO:0044267|GO:0045948|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0010557|GO:0043043|GO:0045727|GO:0010608|GO:0006412|GO:0006417|GO:1990247|GO:0044822 cell|cellular process|metabolic process|binding|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|positive regulation of metabolic process|biosynthetic process|intracellular|regulation of metabolic process|nucleic acid binding|ribonucleoprotein complex binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|translational initiation|cytoplasm|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|regulation of translational initiation|positive regulation of gene expression|positive regulation of protein metabolic process|ribosome binding|positive regulation of cellular protein metabolic process|cellular amide metabolic process|cellular protein metabolic process|positive regulation of translational initiation|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of macromolecule biosynthetic process|peptide biosynthetic process|positive regulation of translation|posttranscriptional regulation of gene expression|translation|regulation of translation|N6-methyladenosine-containing RNA binding|poly(A) RNA binding - - - - 20:63195429-63216234 3045 2995 2252 1211 1567 1306 54.6268672865637 48.8310280367066 36.4251674331193 19.4652842301012 23.0651249284305 21.9579109923565 46.6276875854632 21.4961067169627 1.11711149493055 1.32518767650084e-07 1.97514492732183e-06 UP ENSG00000107862 GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:4181] GO:0040011|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0050900|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0016043|GO:0043227|GO:0008289|GO:0009605|GO:0009893|GO:0031252|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0005085|GO:0031090|GO:0019222|GO:0016032|GO:0060341|GO:1903409|GO:0051726|GO:0007049|GO:0006935|GO:0051640|GO:0006810|GO:0043168|GO:0005543|GO:0043231|GO:0005737|GO:0032880|GO:0006903|GO:0006928|GO:0072593|GO:0051656|GO:0001775|GO:0009966|GO:0002263|GO:0045184|GO:0010646|GO:0005086|GO:0043085|GO:0008104|GO:0007163|GO:0007154|GO:0061024|GO:0016477|GO:0007165|GO:0005783|GO:0051649|GO:0030595|GO:0050790|GO:0010256|GO:0005794|GO:0006996|GO:0016192|GO:0051650|GO:0005802|GO:1903008|GO:0006900|GO:0016050|GO:0005793|GO:0007030|GO:0051345|GO:0035091|GO:0005811|GO:0015031|GO:0005801|GO:0000278|GO:0046907|GO:0048199|GO:0060326|GO:0030010|GO:0007346|GO:0005739|GO:0034613|GO:0035556|GO:0005795|GO:0005788|GO:0000139|GO:0051648|GO:0097111|GO:1903827|GO:1902531|GO:0071621|GO:2000008|GO:0033365|GO:1990266|GO:0005777|GO:0042147|GO:0043087|GO:0035964|GO:0048193|GO:0030593|GO:0034394|GO:0016482|GO:0043547|GO:0016197|GO:1901981|GO:0051056|GO:0007264|GO:0048194|GO:0061162|GO:0090166|GO:0070972|GO:0007265|GO:0046578|GO:0034067|GO:1902936|GO:0006890|GO:0005547|GO:0048205|GO:0006892|GO:0006895|GO:1903420|GO:0070973|GO:0032012|GO:0080025 locomotion|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|leukocyte migration|ion binding|immune response|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cellular component organization|membrane-bounded organelle|lipid binding|response to external stimulus|positive regulation of metabolic process|cell leading edge|biosynthetic process|intracellular|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|organelle membrane|regulation of metabolic process|viral process|regulation of cellular localization|reactive oxygen species biosynthetic process|regulation of cell cycle|cell cycle|chemotaxis|organelle localization|transport|anion binding|phospholipid binding|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|vesicle targeting|movement of cell or subcellular component|reactive oxygen species metabolic process|establishment of organelle localization|cell activation|regulation of signal transduction|cell activation involved in immune response|establishment of protein localization|regulation of cell communication|ARF guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|protein localization|establishment or maintenance of cell polarity|cell communication|membrane organization|cell migration|signal transduction|endoplasmic reticulum|establishment of localization in cell|leukocyte chemotaxis|regulation of catalytic activity|endomembrane system organization|Golgi apparatus|organelle organization|vesicle-mediated transport|establishment of vesicle localization|trans-Golgi network|organelle disassembly|membrane budding|vesicle organization|endoplasmic reticulum-Golgi intermediate compartment|Golgi organization|positive regulation of hydrolase activity|phosphatidylinositol binding|lipid particle|protein transport|cis-Golgi network|mitotic cell cycle|intracellular transport|vesicle targeting, to, from or within Golgi|cell chemotaxis|establishment of cell polarity|regulation of mitotic cell cycle|mitochondrion|cellular protein localization|intracellular signal transduction|Golgi stack|endoplasmic reticulum lumen|Golgi membrane|vesicle localization|endoplasmic reticulum-Golgi intermediate compartment organization|regulation of cellular protein localization|regulation of intracellular signal transduction|granulocyte chemotaxis|regulation of protein localization to cell surface|protein localization to organelle|neutrophil migration|peroxisome|retrograde transport, endosome to Golgi|regulation of GTPase activity|COPI-coated vesicle budding|Golgi vesicle transport|neutrophil chemotaxis|protein localization to cell surface|cytosolic transport|positive regulation of GTPase activity|endosomal transport|phosphatidylinositol phosphate binding|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|Golgi vesicle budding|establishment of monopolar cell polarity|Golgi disassembly|protein localization to endoplasmic reticulum|Ras protein signal transduction|regulation of Ras protein signal transduction|protein localization to Golgi apparatus|phosphatidylinositol bisphosphate binding|retrograde vesicle-mediated transport, Golgi to ER|phosphatidylinositol-3,4,5-trisphosphate binding|COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|Golgi to endosome transport|protein localization to endoplasmic reticulum tubular network|protein localization to endoplasmic reticulum exit site|regulation of ARF protein signal transduction|phosphatidylinositol-3,5-bisphosphate binding K18443 golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1[-] hsa04144 Endocytosis - Homo sapiens (human) 10:102245532-102382899 846 980 1226 2127 2338 2408 8.66541807326982 9.12273629985575 11.3220227769126 19.5202075240064 19.64860118339 23.1155664098841 9.70339238334606 20.7614583724268 -1.0973466699519 1.33347281744803e-07 1.98650187086295e-06 DOWN ENSG00000111863 ADTRP androgen-dependent TFPI-regulating protein [Source:HGNC Symbol;Acc:HGNC:21214] GO:0005623|GO:0016020|GO:0071944|GO:0031224|GO:0005886|GO:0016021 cell|membrane|cell periphery|intrinsic component of membrane|plasma membrane|integral component of membrane - - - - 6:11712054-11807046 14 12 11 49 70 49 0.137833840253752 0.107369189276108 0.0976374666370187 0.432229032765043 0.565439428035724 0.452111986640306 0.11428016538896 0.483260149147024 -2.08022500210135 1.33670125937919e-07 1.99031817443921e-06 DOWN ENSG00000143207 RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:17440] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0030055|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0009893|GO:0031224|GO:0016874|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0051726|GO:0007049|GO:0009314|GO:0022402|GO:0005924|GO:0005912|GO:0031325|GO:0033554|GO:0045786|GO:0043231|GO:0043169|GO:0005737|GO:0045787|GO:0007154|GO:0007165|GO:0019787|GO:0016021|GO:0019538|GO:0031323|GO:0005794|GO:0032268|GO:0005829|GO:0045732|GO:0005813|GO:0000075|GO:0090068|GO:0046872|GO:1903047|GO:0043412|GO:0030163|GO:0004842|GO:0005815|GO:0044770|GO:0044265|GO:0007050|GO:0036211|GO:0000278|GO:0031981|GO:0007346|GO:0010564|GO:0051247|GO:0045930|GO:0006508|GO:0005654|GO:0032270|GO:0010212|GO:0035556|GO:0044267|GO:0042176|GO:0000139|GO:0051246|GO:0072395|GO:0005856|GO:0005634|GO:0006974|GO:0005925|GO:0010948|GO:0044257|GO:0061630|GO:0071156|GO:0010498|GO:0007093|GO:0072331|GO:0042770|GO:1903364|GO:0044772|GO:0030162|GO:0045862|GO:0044774|GO:0000077|GO:0016604|GO:1901990|GO:0051603|GO:0015630|GO:0046914|GO:1901987|GO:0006464|GO:0044773|GO:1901991|GO:0071158|GO:0016607|GO:2000045|GO:1903052|GO:0044819|GO:0019941|GO:1901800|GO:0044783|GO:1902806|GO:2000134|GO:0000082|GO:0031571|GO:0061136|GO:0008270|GO:1902807|GO:0006977|GO:0030330|GO:0043161|GO:0072422|GO:0032446|GO:0072431|GO:0006511|GO:0032434|GO:0032436|GO:0016567 signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intrinsic component of membrane|ligase activity|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|regulation of cell cycle|cell cycle|response to radiation|cell cycle process|cell-substrate adherens junction|adherens junction|positive regulation of cellular metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|cytoplasm|positive regulation of cell cycle|cell communication|signal transduction|ubiquitin-like protein transferase activity|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of cellular protein metabolic process|cytosol|positive regulation of protein catabolic process|centrosome|cell cycle checkpoint|positive regulation of cell cycle process|metal ion binding|mitotic cell cycle process|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|microtubule organizing center|cell cycle phase transition|cellular macromolecule catabolic process|cell cycle arrest|protein modification process|mitotic cell cycle|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|proteolysis|nucleoplasm|positive regulation of cellular protein metabolic process|response to ionizing radiation|intracellular signal transduction|cellular protein metabolic process|regulation of protein catabolic process|Golgi membrane|regulation of protein metabolic process|signal transduction involved in cell cycle checkpoint|cytoskeleton|nucleus|cellular response to DNA damage stimulus|focal adhesion|negative regulation of cell cycle process|cellular protein catabolic process|ubiquitin protein ligase activity|regulation of cell cycle arrest|proteasomal protein catabolic process|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|positive regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of proteolysis|positive regulation of proteolysis|mitotic DNA integrity checkpoint|DNA damage checkpoint|nuclear body|regulation of mitotic cell cycle phase transition|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|transition metal ion binding|regulation of cell cycle phase transition|cellular protein modification process|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|nuclear speck|regulation of G1/S transition of mitotic cell cycle|positive regulation of proteolysis involved in cellular protein catabolic process|mitotic G1/S transition checkpoint|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|G1 DNA damage checkpoint|regulation of cell cycle G1/S phase transition|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic G1 DNA damage checkpoint|regulation of proteasomal protein catabolic process|zinc ion binding|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|proteasome-mediated ubiquitin-dependent protein catabolic process|signal transduction involved in DNA damage checkpoint|protein modification by small protein conjugation|signal transduction involved in mitotic G1 DNA damage checkpoint|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination K10143 E3 ubiquitin-protein ligase RFWD2[2.3.2.27] hsa04120|hsa04115 Ubiquitin mediated proteolysis - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 1:175944831-176207493 299 343 437 792 923 778 3.13384147359022 3.26723589239572 4.12954628313077 7.43754159002814 7.93735764757473 7.64213919764434 3.5102078830389 7.6723461450824 -1.12811133739711 1.34407603189828e-07 2.00030138864862e-06 DOWN ENSG00000152804 HHEX hematopoietically expressed homeobox [Source:HGNC Symbol;Acc:HGNC:4901] GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0032993|GO:0050793|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0007507|GO:0051726|GO:0042127|GO:0007049|GO:0035239|GO:0006725|GO:0051640|GO:0009888|GO:0006810|GO:0035295|GO:1901360|GO:0001568|GO:0061009|GO:0007275|GO:0090009|GO:0061010|GO:0030324|GO:0003676|GO:0071166|GO:0048513|GO:0034641|GO:0030900|GO:0031325|GO:0046483|GO:0090287|GO:0007420|GO:0045786|GO:0043231|GO:0048853|GO:0005737|GO:0000981|GO:0007389|GO:0001763|GO:0060322|GO:0009887|GO:0035264|GO:0001775|GO:0009966|GO:0048729|GO:0046983|GO:0048598|GO:0048568|GO:0009890|GO:0003682|GO:0030323|GO:0019904|GO:0010646|GO:0090288|GO:0006139|GO:0001525|GO:0008104|GO:0046649|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0051649|GO:0008134|GO:0061351|GO:0006403|GO:0048645|GO:0031016|GO:0050790|GO:0043086|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0048732|GO:0031369|GO:0006996|GO:0016525|GO:0061011|GO:0060425|GO:0051276|GO:0000982|GO:0032268|GO:0030111|GO:0003677|GO:0042113|GO:0010468|GO:0034645|GO:0030948|GO:0007166|GO:0002009|GO:0017025|GO:0001944|GO:0043412|GO:0030097|GO:0072358|GO:0030098|GO:0007417|GO:0010629|GO:0045736|GO:0030947|GO:0009798|GO:0051252|GO:0060541|GO:0035050|GO:0070491|GO:0071837|GO:0048754|GO:0007492|GO:0061138|GO:0009790|GO:0001889|GO:0060431|GO:0010628|GO:0030878|GO:0036211|GO:0032269|GO:0007369|GO:0046907|GO:0003002|GO:0035270|GO:0016331|GO:0045765|GO:0001570|GO:0070848|GO:0021846|GO:0051647|GO:0034613|GO:0050658|GO:0060429|GO:0006796|GO:1901342|GO:0044267|GO:0051174|GO:0010467|GO:0048854|GO:0007399|GO:0060562|GO:0071310|GO:0001227|GO:0031328|GO:0051246|GO:0030177|GO:0009059|GO:0030154|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0042803|GO:0008190|GO:0002521|GO:0016055|GO:0000975|GO:0060571|GO:0045893|GO:0048863|GO:0061017|GO:0033365|GO:0009792|GO:0051028|GO:0001078|GO:0051169|GO:0030855|GO:0030183|GO:0045892|GO:0032774|GO:0016973|GO:0043565|GO:2001141|GO:0071363|GO:0016310|GO:0022027|GO:1902679|GO:1904030|GO:0003690|GO:0070365|GO:0007167|GO:0009948|GO:0008301|GO:0009952|GO:0001702|GO:0033673|GO:0060441|GO:0006406|GO:0030099|GO:0007219|GO:0006464|GO:0010621|GO:0071103|GO:0006405|GO:0000079|GO:0043549|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0002573|GO:0006913|GO:0045859|GO:1903507|GO:0006469|GO:0006357|GO:0006468|GO:1903506|GO:0044212|GO:0042325|GO:0001932|GO:0042326|GO:0043009|GO:0001933|GO:0000122|GO:0010944|GO:0034504|GO:0007169|GO:0048010|GO:0051168|GO:0000976|GO:0001012|GO:0071901|GO:0071900|GO:0001701|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|growth|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|protein-DNA complex|regulation of developmental process|developmental growth|intracellular|immune system development|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|heart development|regulation of cell cycle|regulation of cell proliferation|cell cycle|tube morphogenesis|cellular aromatic compound metabolic process|organelle localization|tissue development|transport|tube development|organic cyclic compound metabolic process|blood vessel development|common bile duct development|multicellular organism development|primitive streak formation|gall bladder development|lung development|nucleic acid binding|ribonucleoprotein complex localization|animal organ development|cellular nitrogen compound metabolic process|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|brain development|negative regulation of cell cycle|intracellular membrane-bounded organelle|forebrain morphogenesis|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|morphogenesis of a branching structure|head development|organ morphogenesis|multicellular organism growth|cell activation|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|chromatin binding|respiratory tube development|protein domain specific binding|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|angiogenesis|protein localization|lymphocyte activation|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|establishment of localization in cell|transcription factor binding|neural precursor cell proliferation|RNA localization|organ formation|pancreas development|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|translation initiation factor binding|organelle organization|negative regulation of angiogenesis|hepatic duct development|lung morphogenesis|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|DNA binding|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of vascular endothelial growth factor receptor signaling pathway|cell surface receptor signaling pathway|morphogenesis of an epithelium|TBP-class protein binding|vasculature development|macromolecule modification|hemopoiesis|cardiovascular system development|lymphocyte differentiation|central nervous system development|negative regulation of gene expression|negative regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of vascular endothelial growth factor receptor signaling pathway|axis specification|regulation of RNA metabolic process|respiratory system development|embryonic heart tube development|repressing transcription factor binding|HMG box domain binding|branching morphogenesis of an epithelial tube|endoderm development|morphogenesis of a branching epithelium|embryo development|liver development|primary lung bud formation|positive regulation of gene expression|thyroid gland development|protein modification process|negative regulation of cellular protein metabolic process|gastrulation|intracellular transport|regionalization|endocrine system development|morphogenesis of embryonic epithelium|regulation of angiogenesis|vasculogenesis|response to growth factor|cell proliferation in forebrain|nucleus localization|cellular protein localization|RNA transport|epithelium development|phosphate-containing compound metabolic process|regulation of vasculature development|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|brain morphogenesis|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|eukaryotic initiation factor 4E binding|leukocyte differentiation|Wnt signaling pathway|regulatory region DNA binding|morphogenesis of an epithelial fold|positive regulation of transcription, DNA-templated|stem cell differentiation|hepatoblast differentiation|protein localization to organelle|embryo development ending in birth or egg hatching|mRNA transport|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nuclear transport|epithelial cell differentiation|B cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|poly(A)+ mRNA export from nucleus|sequence-specific DNA binding|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|phosphorylation|interkinetic nuclear migration|negative regulation of RNA biosynthetic process|negative regulation of cyclin-dependent protein kinase activity|double-stranded DNA binding|hepatocyte differentiation|enzyme linked receptor protein signaling pathway|anterior/posterior axis specification|DNA binding, bending|anterior/posterior pattern specification|gastrulation with mouth forming second|negative regulation of kinase activity|epithelial tube branching involved in lung morphogenesis|mRNA export from nucleus|myeloid cell differentiation|Notch signaling pathway|cellular protein modification process|negative regulation of transcription by transcription factor localization|DNA conformation change|RNA export from nucleus|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|myeloid leukocyte differentiation|nucleocytoplasmic transport|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|negative regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|chordate embryonic development|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription by competitive promoter binding|protein localization to nucleus|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|nuclear export|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|in utero embryonic development|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K08024 homeobox protein HEX[-] hsa05202|hsa04950 Transcriptional misregulation in cancer - Homo sapiens (human)|Maturity onset diabetes of the young - Homo sapiens (human) 10:92689951-92695646 443 423 337 180 189 162 6.06589101750647 5.26394874256761 4.16040188964105 2.20831760742508 2.12335311346864 2.07890642072163 5.16341388323838 2.13685904720512 1.27283349748375 1.34806775740091e-07 2.0052423930965e-06 UP ENSG00000109686 SH3D19 SH3 domain containing 19 [Source:HGNC Symbol;Acc:HGNC:30418] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0006810|GO:0070064|GO:0031325|GO:0051128|GO:0043231|GO:0005737|GO:0061024|GO:0051649|GO:0048869|GO:0019538|GO:0031323|GO:0005794|GO:0006996|GO:0016192|GO:0032268|GO:0000902|GO:0005829|GO:0045732|GO:0007010|GO:0030163|GO:0046907|GO:0031981|GO:0051247|GO:0006508|GO:0005654|GO:0022604|GO:0032270|GO:0044267|GO:0042176|GO:0051246|GO:0005634|GO:0030162|GO:0045862|GO:0033619|GO:0048193|GO:0051044|GO:0006509|GO:0006892 developmental process|cell|membrane|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|transport|proline-rich region binding|positive regulation of cellular metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|membrane organization|establishment of localization in cell|cellular developmental process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|vesicle-mediated transport|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|positive regulation of protein catabolic process|cytoskeleton organization|protein catabolic process|intracellular transport|nuclear lumen|positive regulation of protein metabolic process|proteolysis|nucleoplasm|regulation of cell morphogenesis|positive regulation of cellular protein metabolic process|cellular protein metabolic process|regulation of protein catabolic process|regulation of protein metabolic process|nucleus|regulation of proteolysis|positive regulation of proteolysis|membrane protein proteolysis|Golgi vesicle transport|positive regulation of membrane protein ectodomain proteolysis|membrane protein ectodomain proteolysis|post-Golgi vesicle-mediated transport - - - - 4:151102751-151325632 400 508 683 1115 1486 1207 1.54413612738725 1.78225334563867 2.37717246048454 3.85654039640193 4.70665249976433 4.36678170975021 1.90118731117015 4.30999153530549 -1.18078435790092 1.35272540598183e-07 2.01116853935166e-06 DOWN ENSG00000175376 EIF1AD eukaryotic translation initiation factor 1A domain containing [Source:HGNC Symbol;Acc:HGNC:28147] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0003676|GO:0034641|GO:0043231|GO:0006413|GO:0044249|GO:0019538|GO:0034645|GO:0006518|GO:0003723|GO:0031981|GO:0005654|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0005856|GO:0005634|GO:0043043|GO:0006412|GO:0045111|GO:0008135|GO:0003743 cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|nucleic acid binding|cellular nitrogen compound metabolic process|intracellular membrane-bounded organelle|translational initiation|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|nuclear lumen|nucleoplasm|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|cytoskeleton|nucleus|peptide biosynthetic process|translation|intermediate filament cytoskeleton|translation factor activity, RNA binding|translation initiation factor activity - - - - 11:65996545-66002176 2133 2527 1133 704 851 405 21.554525756935 23.207746475202 10.3226615120278 6.37409221661923 7.05578230560363 3.83558738314216 18.3616445813883 5.75515396845501 1.67376885053321 1.35593482358938e-07 2.01446231428441e-06 UP ENSG00000179104 TMTC2 transmembrane and tetratricopeptide repeat containing 2 [Source:HGNC Symbol;Acc:HGNC:25440] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0042175|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0005737|GO:0042592|GO:0005783|GO:0016021|GO:0048878|GO:0050801|GO:0055065|GO:0055074 cell|membrane|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|endoplasmic reticulum|integral component of membrane|chemical homeostasis|ion homeostasis|metal ion homeostasis|calcium ion homeostasis - - - - 12:82686880-83134870 60 63 122 233 253 387 0.298383897619277 0.284739205261477 0.547013645847711 1.03819303787979 1.03231589931155 1.80369988974236 0.376712249576155 1.29140294231123 -1.77740436784731 1.35629036367377e-07 2.01446231428441e-06 DOWN ENSG00000113318 MSH3 mutS homolog 3 [Source:HGNC Symbol;Acc:HGNC:7326] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0006281|GO:0016445|GO:0006725|GO:1901360|GO:0043570|GO:0007275|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0002377|GO:0006139|GO:0043085|GO:0032300|GO:0050790|GO:0000166|GO:1990391|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0051053|GO:0035639|GO:0051345|GO:0016447|GO:0001883|GO:0032549|GO:0031981|GO:0006298|GO:0032302|GO:0005654|GO:0006259|GO:0017076|GO:0005634|GO:0006974|GO:0045910|GO:0043566|GO:0003697|GO:0005524|GO:0030554|GO:0003690|GO:0003684|GO:0000018|GO:0006310|GO:0051096|GO:0016444|GO:0030983|GO:0032357|GO:0000406|GO:0000403|GO:0000404|GO:0032139|GO:0032138|GO:0032181|GO:0032142 developmental process|macromolecular complex|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|DNA repair|somatic diversification of immunoglobulins|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|maintenance of DNA repeat elements|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|immunoglobulin production|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|mismatch repair complex|regulation of catalytic activity|nucleotide binding|DNA repair complex|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|negative regulation of DNA metabolic process|purine ribonucleoside triphosphate binding|positive regulation of hydrolase activity|somatic recombination of immunoglobulin gene segments|purine nucleoside binding|ribonucleoside binding|nuclear lumen|mismatch repair|MutSbeta complex|nucleoplasm|DNA metabolic process|purine nucleotide binding|nucleus|cellular response to DNA damage stimulus|negative regulation of DNA recombination|structure-specific DNA binding|single-stranded DNA binding|ATP binding|adenyl nucleotide binding|double-stranded DNA binding|damaged DNA binding|regulation of DNA recombination|DNA recombination|positive regulation of helicase activity|somatic cell DNA recombination|mismatched DNA binding|oxidized purine DNA binding|double-strand/single-strand DNA junction binding|Y-form DNA binding|heteroduplex DNA loop binding|dinucleotide insertion or deletion binding|single base insertion or deletion binding|dinucleotide repeat insertion binding|single guanine insertion binding K08736 DNA mismatch repair protein MSH3[-] hsa05200|hsa05210|hsa03430 Pathways in cancer - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Mismatch repair - Homo sapiens (human) 5:80654648-80876460 160 200 232 483 514 467 2.32066847637843 2.63634619967478 3.0338543311698 6.27678775037983 6.1167922983174 6.34802573562978 2.66362300240767 6.247201928109 -1.22982025875404 1.39762192651538e-07 2.0748187466032e-06 DOWN ENSG00000112379 ARFGEF3 ARFGEF family member 3 [Source:HGNC Symbol;Acc:HGNC:21213] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0031224|GO:0005622|GO:0012505|GO:0005085|GO:0031090|GO:0019222|GO:0031982|GO:0043231|GO:0030133|GO:0005737|GO:0012506|GO:0009966|GO:0030658|GO:0010646|GO:0005086|GO:0043085|GO:0007154|GO:0044092|GO:0007165|GO:0050790|GO:0043086|GO:0016021|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0043412|GO:0031410|GO:0051345|GO:0016023|GO:0036211|GO:0032269|GO:0051346|GO:0031988|GO:0006796|GO:0035556|GO:0030659|GO:0044267|GO:0051174|GO:0051246|GO:1902531|GO:0010923|GO:0016311|GO:0043087|GO:0043547|GO:0051056|GO:0007264|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0007265|GO:0046578|GO:0035305|GO:0035303|GO:0035308|GO:0032012 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|intrinsic component of membrane|intracellular|endomembrane system|guanyl-nucleotide exchange factor activity|organelle membrane|regulation of metabolic process|vesicle|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|vesicle membrane|regulation of signal transduction|transport vesicle membrane|regulation of cell communication|ARF guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|cell communication|negative regulation of molecular function|signal transduction|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|cytoplasmic vesicle|positive regulation of hydrolase activity|cytoplasmic, membrane-bounded vesicle|protein modification process|negative regulation of cellular protein metabolic process|negative regulation of hydrolase activity|membrane-bounded vesicle|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic vesicle membrane|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of intracellular signal transduction|negative regulation of phosphatase activity|dephosphorylation|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|Ras protein signal transduction|regulation of Ras protein signal transduction|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation|regulation of ARF protein signal transduction - - - - 6:138161921-138344663 302 366 748 1127 1406 2165 1.43594339749811 1.58158320966964 3.20660850136591 4.8012244709922 5.4850894969514 9.64755602815504 2.07471170284455 6.64462333203288 -1.6792765420429 1.40166903692761e-07 2.07979261572747e-06 DOWN ENSG00000122642 FKBP9 FK506 binding protein 9 [Source:HGNC Symbol;Acc:HGNC:3725] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0008144|GO:0044237|GO:0006457|GO:0043227|GO:0016853|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0061077|GO:0005527|GO:0043231|GO:0043169|GO:0005737|GO:0005783|GO:0019538|GO:0046872|GO:0043412|GO:0036211|GO:0005528|GO:0003755|GO:0044267|GO:0005509|GO:0006464|GO:0018193|GO:0018208|GO:0000413 cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|drug binding|cellular metabolic process|protein folding|membrane-bounded organelle|isomerase activity|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|chaperone-mediated protein folding|macrolide binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|endoplasmic reticulum|protein metabolic process|metal ion binding|macromolecule modification|protein modification process|FK506 binding|peptidyl-prolyl cis-trans isomerase activity|cellular protein metabolic process|calcium ion binding|cellular protein modification process|peptidyl-amino acid modification|peptidyl-proline modification|protein peptidyl-prolyl isomerization - - - - 7:32957404-33006931 476 479 611 1207 1139 1174 3.14709470287878 2.87818002808974 3.64214928222348 7.15002264780462 6.17865956035622 7.27444311634236 3.222474671064 6.86770844150107 -1.09165977421522 1.40727505925515e-07 2.08707350317949e-06 DOWN ENSG00000106415 GLCCI1 glucocorticoid induced 1 [Source:HGNC Symbol;Acc:HGNC:18713] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 7:7968794-8094272 220 264 284 562 656 615 1.2864439711527 1.40297989161564 1.49727201195259 2.94443423319933 3.14731164367918 3.37032992726097 1.39556529157364 3.15402526804649 -1.1763445956071 1.41906420411886e-07 2.10351254964074e-06 DOWN ENSG00000174516 PELI3 pellino E3 ubiquitin protein ligase family member 3 [Source:HGNC Symbol;Acc:HGNC:30010] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0071704|GO:0044237|GO:0023051|GO:0023057|GO:0016874|GO:0005622|GO:0005515|GO:0010941|GO:0060761|GO:0005737|GO:0009966|GO:0060548|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0019538|GO:0010033|GO:0005829|GO:0007166|GO:0001959|GO:0043412|GO:0034097|GO:0043069|GO:2001234|GO:0036211|GO:0012501|GO:0044267|GO:0071310|GO:0001960|GO:0043067|GO:0097190|GO:2001237|GO:0019221|GO:0010803|GO:2001236|GO:0010804|GO:0008063|GO:0042981|GO:0071345|GO:0043066|GO:0034612|GO:0006464|GO:0097191|GO:0006915|GO:0071356|GO:0033209|GO:0032446|GO:0016567 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|cellular metabolic process|regulation of signaling|negative regulation of signaling|ligase activity|intracellular|protein binding|regulation of cell death|negative regulation of response to cytokine stimulus|cytoplasm|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|cell death|protein metabolic process|response to organic substance|cytosol|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|macromolecule modification|response to cytokine|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|protein modification process|programmed cell death|cellular protein metabolic process|cellular response to organic substance|negative regulation of cytokine-mediated signaling pathway|regulation of programmed cell death|apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|cytokine-mediated signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway|regulation of extrinsic apoptotic signaling pathway|negative regulation of tumor necrosis factor-mediated signaling pathway|Toll signaling pathway|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|response to tumor necrosis factor|cellular protein modification process|extrinsic apoptotic signaling pathway|apoptotic process|cellular response to tumor necrosis factor|tumor necrosis factor-mediated signaling pathway|protein modification by small protein conjugation|protein ubiquitination - - - - 11:66466327-66477337 410 529 408 191 250 176 2.31184424294345 2.7108818831794 2.07419511607188 0.964952258232534 1.15659862817085 0.930073498464474 2.36564041406491 1.01720812828929 1.21761590000711 1.44121784819577e-07 2.13443853485344e-06 UP ENSG00000175471 MCTP1 multiple C2 domains, transmembrane 1 [Source:HGNC Symbol;Acc:HGNC:26183] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0043167|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0043231|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0005783|GO:0016021|GO:0046872|GO:0035556|GO:0005509|GO:0019932|GO:0019722 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|ion binding|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell communication|signal transduction|endoplasmic reticulum|integral component of membrane|metal ion binding|intracellular signal transduction|calcium ion binding|second-messenger-mediated signaling|calcium-mediated signaling - - - - 5:94703741-95284575 15 12 17 60 77 50 0.0636800248887844 0.0462998214469352 0.0650698301384744 0.228227278837234 0.268212130565379 0.198938324894269 0.0583498921580647 0.231792578098961 -1.99003247792736 1.44203108807734e-07 2.13443853485344e-06 DOWN ENSG00000204604 ZNF468 zinc finger protein 468 [Source:HGNC Symbol;Acc:HGNC:33105] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:52838008-52857649 235 298 214 99 112 101 1.65833492555179 1.91117478247832 1.36154922042378 0.625945729682211 0.648472831673851 0.66796752635219 1.64368630948463 0.647462029236084 1.34406750034451 1.44207225993146e-07 2.13443853485344e-06 UP ENSG00000152117 AC093838.4 - - - - - - - 2:131492813-131521573 863 837 621 354 413 228 14.4010098878496 12.6936926431127 9.3430374358283 5.29277008829322 5.65458065398147 3.56571217230021 12.1459133222635 4.83768763819163 1.32808145382119 1.44968283692919e-07 2.14463981237285e-06 UP ENSG00000081760 AACS acetoacetyl-CoA synthetase [Source:HGNC Symbol;Acc:HGNC:21298] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0009605|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0048856|GO:0060341|GO:0044255|GO:0046887|GO:0009888|GO:0006810|GO:0006082|GO:0009991|GO:0007275|GO:0048513|GO:0043168|GO:0044281|GO:0032940|GO:0001882|GO:0010243|GO:0005737|GO:0007267|GO:0032880|GO:0051222|GO:0042592|GO:0045184|GO:0046883|GO:0019725|GO:0042493|GO:0010646|GO:0008104|GO:0007154|GO:0006629|GO:0009725|GO:0051047|GO:0000166|GO:0046950|GO:0010817|GO:0048869|GO:0044249|GO:0010033|GO:0048732|GO:0042594|GO:0007584|GO:0005829|GO:0009743|GO:0090276|GO:0014074|GO:0033993|GO:0035639|GO:0002793|GO:0048878|GO:0006631|GO:0001883|GO:0051223|GO:0015031|GO:0001889|GO:0046951|GO:0070201|GO:0042886|GO:0032549|GO:0055082|GO:0050714|GO:0051046|GO:0016878|GO:0009914|GO:0009306|GO:0070542|GO:0014070|GO:0046903|GO:0071310|GO:0017076|GO:0030154|GO:0061448|GO:0031667|GO:0032870|GO:0048545|GO:0097305|GO:0060612|GO:0090277|GO:0050796|GO:0071322|GO:0002790|GO:0030073|GO:0034201|GO:0045444|GO:0001678|GO:0030729|GO:0005524|GO:0034284|GO:0050708|GO:0030554|GO:0015833|GO:0071383|GO:0071407|GO:0045471|GO:0032024|GO:0019752|GO:0033574|GO:0047760|GO:0071396|GO:0046879|GO:0033500|GO:0071333|GO:0042593|GO:0030072|GO:0070723|GO:0071394|GO:0050872|GO:0032787|GO:0036315|GO:0071397|GO:0009749 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|response to external stimulus|biosynthetic process|ligase activity|intracellular|protein binding|anatomical structure development|regulation of cellular localization|cellular lipid metabolic process|positive regulation of hormone secretion|tissue development|transport|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|animal organ development|anion binding|small molecule metabolic process|secretion by cell|nucleoside binding|response to organonitrogen compound|cytoplasm|cell-cell signaling|regulation of protein localization|positive regulation of protein transport|homeostatic process|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|response to drug|regulation of cell communication|protein localization|cell communication|lipid metabolic process|response to hormone|positive regulation of secretion|nucleotide binding|cellular ketone body metabolic process|regulation of hormone levels|cellular developmental process|cellular biosynthetic process|response to organic substance|gland development|response to starvation|response to nutrient|cytosol|response to carbohydrate|regulation of peptide hormone secretion|response to purine-containing compound|response to lipid|purine ribonucleoside triphosphate binding|positive regulation of peptide secretion|chemical homeostasis|fatty acid metabolic process|purine nucleoside binding|regulation of protein transport|protein transport|liver development|ketone body biosynthetic process|regulation of establishment of protein localization|amide transport|ribonucleoside binding|cellular chemical homeostasis|positive regulation of protein secretion|regulation of secretion|acid-thiol ligase activity|hormone transport|protein secretion|response to fatty acid|response to organic cyclic compound|secretion|cellular response to organic substance|purine nucleotide binding|cell differentiation|connective tissue development|response to nutrient levels|cellular response to hormone stimulus|response to steroid hormone|response to alcohol|adipose tissue development|positive regulation of peptide hormone secretion|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|insulin secretion|response to oleic acid|fat cell differentiation|cellular glucose homeostasis|acetoacetate-CoA ligase activity|ATP binding|response to monosaccharide|regulation of protein secretion|adenyl nucleotide binding|peptide transport|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|response to ethanol|positive regulation of insulin secretion|carboxylic acid metabolic process|response to testosterone|butyrate-CoA ligase activity|cellular response to lipid|hormone secretion|carbohydrate homeostasis|cellular response to glucose stimulus|glucose homeostasis|peptide hormone secretion|response to cholesterol|cellular response to testosterone stimulus|white fat cell differentiation|monocarboxylic acid metabolic process|cellular response to sterol|cellular response to cholesterol|response to glucose K01907 acetoacetyl-CoA synthetase[6.2.1.16] hsa00280|hsa00650 Valine, leucine and isoleucine degradation - Homo sapiens (human)|Butanoate metabolism - Homo sapiens (human) 12:125065379-125143333 236 297 441 764 874 754 0.778961130472387 0.890922455421656 1.31237086803399 2.25940779414496 2.36691471047437 2.33240296792428 0.994084817976011 2.31957515751454 -1.22241973555188 1.46629579113169e-07 2.1681423748611e-06 DOWN ENSG00000116691 MIIP migration and invasion inhibitory protein [Source:HGNC Symbol;Acc:HGNC:25715] GO:0040011|GO:0009987|GO:0005488|GO:0040013|GO:0048523|GO:0050794|GO:0040012|GO:0048870|GO:0005515|GO:0051726|GO:0007049|GO:0022402|GO:0045786|GO:0006928|GO:0051270|GO:0016477|GO:0051271|GO:2000145|GO:2000146|GO:1903047|GO:0044770|GO:0030334|GO:0000278|GO:0007346|GO:0010564|GO:0045930|GO:0030336|GO:0010948|GO:0000086|GO:0044772|GO:1901990|GO:1901987|GO:1901991|GO:0010389|GO:0010972|GO:1902750|GO:1902749 locomotion|cellular process|binding|negative regulation of locomotion|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|cell motility|protein binding|regulation of cell cycle|cell cycle|cell cycle process|negative regulation of cell cycle|movement of cell or subcellular component|regulation of cellular component movement|cell migration|negative regulation of cellular component movement|regulation of cell motility|negative regulation of cell motility|mitotic cell cycle process|cell cycle phase transition|regulation of cell migration|mitotic cell cycle|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|negative regulation of cell migration|negative regulation of cell cycle process|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|regulation of mitotic cell cycle phase transition|regulation of cell cycle phase transition|negative regulation of mitotic cell cycle phase transition|regulation of G2/M transition of mitotic cell cycle|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of cell cycle G2/M phase transition|regulation of cell cycle G2/M phase transition - - - - 1:12019466-12032045 450 464 497 244 251 209 5.28675653006976 4.95422172629198 5.26438423649641 2.56841306931927 2.41946404550534 2.30119310790618 5.16845416428605 2.4296900742436 1.08896054996691 1.46737054737056e-07 2.16865744164359e-06 UP ENSG00000169118 CSNK1G1 casein kinase 1, gamma 1 [Source:HGNC Symbol;Acc:HGNC:2454] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0033218|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0005622|GO:0005515|GO:0016740|GO:0051219|GO:0042277|GO:0043168|GO:0001882|GO:0016772|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0000166|GO:0001948|GO:0019538|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0016055|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0018193|GO:0004674|GO:0046777|GO:0018105 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|amide binding|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|intracellular|protein binding|transferase activity|phosphoprotein binding|peptide binding|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|cytoplasm|cell communication|signal transduction|nucleotide binding|glycoprotein binding|protein metabolic process|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|Wnt signaling pathway|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|protein autophosphorylation|peptidyl-serine phosphorylation K08958 casein kinase 1, gamma[2.7.11.1] hsa04340 Hedgehog signaling pathway - Homo sapiens (human) 15:64165517-64356259 195 218 362 601 665 792 0.704909763588855 0.716201546056682 1.17983718763423 1.94657491789456 1.97237150022744 2.68320055176513 0.866982832426589 2.20071565662904 -1.34389742262503 1.46859348700313e-07 2.16939089366608e-06 DOWN ENSG00000138398 PPIG peptidylprolyl isomerase G (cyclophilin G) [Source:HGNC Symbol;Acc:HGNC:14650] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0033218|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0008144|GO:0044237|GO:0006457|GO:0043227|GO:0016853|GO:0005622|GO:0005515|GO:0042277|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0016018|GO:0006139|GO:0019538|GO:0003723|GO:0043412|GO:0036211|GO:0031981|GO:0003755|GO:0005654|GO:0016363|GO:0044267|GO:0010467|GO:0034399|GO:0016070|GO:0005634|GO:0006396|GO:0016604|GO:0044822|GO:0006464|GO:0016607|GO:0018193|GO:0008380|GO:0018208|GO:0000413 cell|cellular process|metabolic process|binding|catalytic activity|amide binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|drug binding|cellular metabolic process|protein folding|membrane-bounded organelle|isomerase activity|intracellular|protein binding|peptide binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cyclosporin A binding|nucleobase-containing compound metabolic process|protein metabolic process|RNA binding|macromolecule modification|protein modification process|nuclear lumen|peptidyl-prolyl cis-trans isomerase activity|nucleoplasm|nuclear matrix|cellular protein metabolic process|gene expression|nuclear periphery|RNA metabolic process|nucleus|RNA processing|nuclear body|poly(A) RNA binding|cellular protein modification process|nuclear speck|peptidyl-amino acid modification|RNA splicing|peptidyl-proline modification|protein peptidyl-prolyl isomerization - - - - 2:169584340-169641406 460 496 667 1196 1372 1150 2.5659619082076 2.51451483956582 3.35453507877701 5.97752030512519 6.27934235526875 6.01200200791976 2.81167060885014 6.08962155610457 -1.11492498303516 1.47639266183215e-07 2.17983316153991e-06 DOWN ENSG00000110871 COQ5 coenzyme Q5, methyltransferase [Source:HGNC Symbol;Acc:HGNC:28722] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0032259|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0016740|GO:0031090|GO:0019866|GO:0044281|GO:0043231|GO:0005737|GO:0031966|GO:0051186|GO:0042180|GO:0044249|GO:0005740|GO:0008168|GO:0005743|GO:0005739|GO:1901661|GO:0009108|GO:0006743|GO:0008757|GO:0006744 cell|membrane|cellular process|metabolic process|catalytic activity|methylation|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|transferase activity|organelle membrane|organelle inner membrane|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|cofactor metabolic process|cellular ketone metabolic process|cellular biosynthetic process|mitochondrial envelope|methyltransferase activity|mitochondrial inner membrane|mitochondrion|quinone metabolic process|coenzyme biosynthetic process|ubiquinone metabolic process|S-adenosylmethionine-dependent methyltransferase activity|ubiquinone biosynthetic process K06127 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase[2.1.1.201] hsa01100|hsa00130 Metabolic pathways - Homo sapiens (human)|Ubiquinone and other terpenoid-quinone biosynthesis - Homo sapiens (human) 12:120503274-120534434 96 88 144 288 301 349 1.5374130287001 1.28079750576367 2.07918779581431 4.13245287947655 3.95505450023291 5.238083840523 1.63246611009269 4.44186374007749 -1.44411209521269 1.48050919565479e-07 2.18483052531281e-06 DOWN ENSG00000115380 EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 [Source:HGNC Symbol;Acc:HGNC:3218] GO:0040011|GO:0032502|GO:0031012|GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0005604|GO:1903561|GO:0051716|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0005578|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0009058|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0009791|GO:0048569|GO:0045595|GO:0006725|GO:0061037|GO:0009888|GO:0048468|GO:0051130|GO:1901360|GO:0007275|GO:0045596|GO:0048513|GO:0050877|GO:0005102|GO:0034641|GO:0043062|GO:0016772|GO:0031982|GO:0046483|GO:0051128|GO:0043169|GO:0004888|GO:0005737|GO:0007423|GO:0006928|GO:0009887|GO:0048598|GO:0048568|GO:0006139|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0070062|GO:0030030|GO:0048869|GO:2000145|GO:0044249|GO:0019538|GO:0031323|GO:0050768|GO:0031175|GO:0031344|GO:0010468|GO:0034645|GO:0051216|GO:0046872|GO:0007166|GO:0001654|GO:0070851|GO:0043412|GO:0051252|GO:0010721|GO:0031346|GO:0009790|GO:0030334|GO:0036211|GO:0048563|GO:0032330|GO:0031345|GO:0007600|GO:0016301|GO:0032331|GO:0006796|GO:0044267|GO:0010467|GO:0048562|GO:0007399|GO:0030198|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0061035|GO:0016070|GO:0008083|GO:0016773|GO:0051960|GO:0048666|GO:0008347|GO:0030182|GO:0048050|GO:0050953|GO:0010975|GO:0043010|GO:0005154|GO:0002062|GO:0032774|GO:1903975|GO:2001141|GO:0016310|GO:0005509|GO:0048048|GO:0007167|GO:0004672|GO:0045665|GO:0022008|GO:0004714|GO:0006464|GO:0050767|GO:0010977|GO:0006351|GO:0006355|GO:0048592|GO:0006468|GO:0048699|GO:0014013|GO:1903506|GO:0004713|GO:0018193|GO:0042063|GO:0005006|GO:0007601|GO:0045664|GO:0007169|GO:0038127|GO:0018108|GO:0007173 locomotion|developmental process|extracellular matrix|signal transducer activity|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|basement membrane|extracellular vesicle|cellular response to stimulus|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|biosynthetic process|extracellular space|regulation of developmental process|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|post-embryonic development|post-embryonic organ development|regulation of cell differentiation|cellular aromatic compound metabolic process|negative regulation of cartilage development|tissue development|cell development|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|negative regulation of cell differentiation|animal organ development|neurological system process|receptor binding|cellular nitrogen compound metabolic process|extracellular structure organization|transferase activity, transferring phosphorus-containing groups|vesicle|heterocycle metabolic process|regulation of cellular component organization|cation binding|transmembrane signaling receptor activity|cytoplasm|sensory organ development|movement of cell or subcellular component|organ morphogenesis|embryonic morphogenesis|embryonic organ development|nucleobase-containing compound metabolic process|cell communication|regulation of cellular component movement|cell migration|signal transduction|extracellular exosome|cell projection organization|cellular developmental process|regulation of cell motility|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|negative regulation of neurogenesis|neuron projection development|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|metal ion binding|cell surface receptor signaling pathway|eye development|growth factor receptor binding|macromolecule modification|regulation of RNA metabolic process|negative regulation of cell development|positive regulation of cell projection organization|embryo development|regulation of cell migration|protein modification process|post-embryonic organ morphogenesis|regulation of chondrocyte differentiation|negative regulation of cell projection organization|sensory perception|kinase activity|negative regulation of chondrocyte differentiation|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|embryonic organ morphogenesis|nervous system development|extracellular matrix organization|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|regulation of cartilage development|RNA metabolic process|growth factor activity|phosphotransferase activity, alcohol group as acceptor|regulation of nervous system development|neuron development|glial cell migration|neuron differentiation|post-embryonic eye morphogenesis|sensory perception of light stimulus|regulation of neuron projection development|camera-type eye development|epidermal growth factor receptor binding|chondrocyte differentiation|RNA biosynthetic process|regulation of glial cell migration|regulation of RNA biosynthetic process|phosphorylation|calcium ion binding|embryonic eye morphogenesis|enzyme linked receptor protein signaling pathway|protein kinase activity|negative regulation of neuron differentiation|neurogenesis|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|regulation of neurogenesis|negative regulation of neuron projection development|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|protein phosphorylation|generation of neurons|regulation of gliogenesis|regulation of nucleic acid-templated transcription|protein tyrosine kinase activity|peptidyl-amino acid modification|gliogenesis|epidermal growth factor-activated receptor activity|visual perception|regulation of neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|epidermal growth factor receptor signaling pathway - - - - 2:55865967-55924139 267 301 480 835 1027 757 2.16665777560746 2.21985870717653 3.51183480304894 6.07103919649831 6.83780967896668 5.75709363791653 2.63278376194431 6.22198083779384 -1.24078491814262 1.51334654043844e-07 2.23218614714671e-06 DOWN ENSG00000099810 MTAP methylthioadenosine phosphorylase [Source:HGNC Symbol;Acc:HGNC:7413] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0032259|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0006139|GO:0055086|GO:0070062|GO:0016757|GO:0009725|GO:0044249|GO:0010033|GO:0006790|GO:0005829|GO:0033993|GO:0009308|GO:0009116|GO:0000096|GO:0016758|GO:0008652|GO:0014070|GO:1901137|GO:0016763|GO:0005634|GO:0048545|GO:0097305|GO:0043101|GO:0004731|GO:0006576|GO:0004645|GO:0019752|GO:0033574|GO:0006555|GO:0042278|GO:0000097|GO:0009086|GO:0071267|GO:0006166|GO:0017061|GO:0006595|GO:0019509 cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|methylation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|extracellular exosome|transferase activity, transferring glycosyl groups|response to hormone|cellular biosynthetic process|response to organic substance|sulfur compound metabolic process|cytosol|response to lipid|amine metabolic process|nucleoside metabolic process|sulfur amino acid metabolic process|transferase activity, transferring hexosyl groups|cellular amino acid biosynthetic process|response to organic cyclic compound|carbohydrate derivative biosynthetic process|transferase activity, transferring pentosyl groups|nucleus|response to steroid hormone|response to alcohol|purine-containing compound salvage|purine-nucleoside phosphorylase activity|cellular biogenic amine metabolic process|phosphorylase activity|carboxylic acid metabolic process|response to testosterone|methionine metabolic process|purine nucleoside metabolic process|sulfur amino acid biosynthetic process|methionine biosynthetic process|L-methionine salvage|purine ribonucleoside salvage|S-methyl-5-thioadenosine phosphorylase activity|polyamine metabolic process|L-methionine biosynthetic process from methylthioadenosine K00772 5'-methylthioadenosine phosphorylase[2.4.2.28] hsa01100|hsa00270 Metabolic pathways - Homo sapiens (human)|Cysteine and methionine metabolism - Homo sapiens (human) 9:21802543-21937651 363 395 725 1241 1593 1102 1.23254016117403 1.2189082103341 2.21945565215893 3.77540331105851 4.437901030824 3.506746919973 1.55696800788902 3.90668375395184 -1.3272051734282 1.51424445305924e-07 2.23240760008052e-06 DOWN ENSG00000011143 MKS1 Meckel syndrome, type 1 [Source:HGNC Symbol;Acc:HGNC:7121] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0023051|GO:0009653|GO:0016043|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0035239|GO:0009888|GO:0007164|GO:0048468|GO:0035295|GO:0048839|GO:0061009|GO:0007275|GO:0048513|GO:0022607|GO:0005737|GO:0007389|GO:0001763|GO:0060322|GO:0007423|GO:0009887|GO:0042592|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0072372|GO:0036038|GO:0048871|GO:0036064|GO:0010646|GO:0007154|GO:0035148|GO:0007165|GO:0035869|GO:0030030|GO:0048869|GO:0006996|GO:0030111|GO:0000902|GO:0005829|GO:0005813|GO:0060113|GO:0042733|GO:0007166|GO:0002009|GO:0043583|GO:0001894|GO:0005815|GO:0048754|GO:0008589|GO:0061138|GO:0009790|GO:0001736|GO:0072175|GO:0005814|GO:0044782|GO:2000027|GO:0003002|GO:0021532|GO:0016331|GO:0030031|GO:0060122|GO:0001841|GO:0070925|GO:0060429|GO:0042384|GO:0035108|GO:0032990|GO:0007399|GO:0060562|GO:0030154|GO:0001501|GO:0048858|GO:0060606|GO:0060173|GO:1990403|GO:0005856|GO:0051960|GO:0031513|GO:0045995|GO:0048666|GO:0030182|GO:0060271|GO:0016055|GO:0048706|GO:0035058|GO:1903887|GO:0009792|GO:0021904|GO:0001843|GO:0060828|GO:0007224|GO:0001838|GO:0090175|GO:0015630|GO:0009855|GO:0009953|GO:0060119|GO:0022008|GO:0030326|GO:1901620|GO:0010669|GO:0001738|GO:0035567|GO:0048699|GO:0007368|GO:0060070|GO:0060831|GO:2000095|GO:0043009|GO:0042490|GO:0060071 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|regulation of signaling|anatomical structure morphogenesis|cellular component organization|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|tube morphogenesis|tissue development|establishment of tissue polarity|cell development|tube development|inner ear development|common bile duct development|multicellular organism development|animal organ development|cellular component assembly|cytoplasm|pattern specification process|morphogenesis of a branching structure|head development|sensory organ development|organ morphogenesis|homeostatic process|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|primary cilium|TCTN-B9D complex|multicellular organismal homeostasis|ciliary basal body|regulation of cell communication|cell communication|tube formation|signal transduction|ciliary transition zone|cell projection organization|cellular developmental process|organelle organization|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|centrosome|inner ear receptor cell differentiation|embryonic digit morphogenesis|cell surface receptor signaling pathway|morphogenesis of an epithelium|ear development|tissue homeostasis|microtubule organizing center|branching morphogenesis of an epithelial tube|regulation of smoothened signaling pathway|morphogenesis of a branching epithelium|embryo development|establishment of planar polarity|epithelial tube formation|centriole|cilium organization|regulation of organ morphogenesis|regionalization|neural tube patterning|morphogenesis of embryonic epithelium|cell projection assembly|inner ear receptor stereocilium organization|neural tube formation|organelle assembly|epithelium development|cilium assembly|limb morphogenesis|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|cell differentiation|skeletal system development|cell projection morphogenesis|tube closure|limb development|embryonic brain development|cytoskeleton|regulation of nervous system development|nonmotile primary cilium|regulation of embryonic development|neuron development|neuron differentiation|cilium morphogenesis|Wnt signaling pathway|embryonic skeletal system development|nonmotile primary cilium assembly|motile primary cilium assembly|embryo development ending in birth or egg hatching|dorsal/ventral neural tube patterning|neural tube closure|regulation of canonical Wnt signaling pathway|smoothened signaling pathway|embryonic epithelial tube formation|regulation of establishment of planar polarity|microtubule cytoskeleton|determination of bilateral symmetry|dorsal/ventral pattern formation|inner ear receptor cell development|neurogenesis|embryonic limb morphogenesis|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|epithelial structure maintenance|morphogenesis of a polarized epithelium|non-canonical Wnt signaling pathway|generation of neurons|determination of left/right symmetry|canonical Wnt signaling pathway|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|regulation of Wnt signaling pathway, planar cell polarity pathway|chordate embryonic development|mechanoreceptor differentiation|Wnt signaling pathway, planar cell polarity pathway - - - - 17:58205437-58219605 70 75 100 221 242 220 0.623935003681735 0.607557721848296 0.803638067409763 1.76495558713711 1.76981558154287 1.83778949327223 0.678376930979931 1.79085355398407 -1.40048835131782 1.53870539037177e-07 2.26734998638494e-06 DOWN ENSG00000130433 CACNG6 calcium channel, voltage-dependent, gamma subunit 6 [Source:HGNC Symbol;Acc:HGNC:13625] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0050794|GO:0071944|GO:0031224|GO:0005886|GO:0043234|GO:0006810|GO:0098797|GO:0022891|GO:1902495|GO:0055085|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0005891|GO:0034765|GO:0034702|GO:0043269|GO:0034220|GO:0098655|GO:0005216|GO:0034703|GO:0006812|GO:0008324|GO:0005244|GO:0034704|GO:0022890|GO:0030001|GO:0005261|GO:0005262|GO:0070588|GO:0022843|GO:0046873|GO:0006816|GO:0015085|GO:0005245 macromolecular complex|transporter activity|cell|membrane|cellular process|transmembrane transporter activity|regulation of cellular process|cell periphery|intrinsic component of membrane|plasma membrane|protein complex|transport|plasma membrane protein complex|substrate-specific transmembrane transporter activity|transmembrane transporter complex|transmembrane transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|voltage-gated calcium channel complex|regulation of ion transmembrane transport|ion channel complex|regulation of ion transport|ion transmembrane transport|cation transmembrane transport|ion channel activity|cation channel complex|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|calcium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|calcium channel activity|calcium ion transmembrane transport|voltage-gated cation channel activity|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity|voltage-gated calcium channel activity K04871 voltage-dependent calcium channel gamma-6[-] hsa04010|hsa04921|hsa04261|hsa05414|hsa05410|hsa04260|hsa05412 MAPK signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 19:53992288-54012669 292 309 274 691 772 668 6.58435703989441 6.33242166627043 5.57051928869089 13.9606829369907 14.2828999955133 14.1168150256925 6.16243266495191 14.1201326527322 -1.19618175939385 1.54152420717967e-07 2.27038301337651e-06 DOWN ENSG00000137273 FOXF2 forkhead box F2 [Source:HGNC Symbol;Acc:HGNC:3810] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0044237|GO:0003006|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0048565|GO:0006725|GO:0009888|GO:0007164|GO:0048468|GO:0035295|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043062|GO:0031325|GO:0046483|GO:0043231|GO:0048608|GO:0000981|GO:0007423|GO:0009887|GO:0005667|GO:0048729|GO:0048598|GO:0048568|GO:0007548|GO:0009890|GO:0006139|GO:0008134|GO:0048869|GO:0048806|GO:0044249|GO:0031324|GO:0031323|GO:0060021|GO:0000902|GO:0003677|GO:0010468|GO:0034645|GO:0055123|GO:0001654|GO:0002009|GO:0061458|GO:0010629|GO:0051252|GO:0000904|GO:0009790|GO:0001736|GO:0010628|GO:0003705|GO:0060485|GO:0060429|GO:0048864|GO:0010467|GO:0048562|GO:0030198|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0048566|GO:0016070|GO:0010557|GO:0005634|GO:0031076|GO:0000975|GO:0045893|GO:0048863|GO:0045892|GO:0043010|GO:0042249|GO:0032774|GO:0043565|GO:2001141|GO:0014031|GO:1902679|GO:0048048|GO:0003690|GO:0048762|GO:0048596|GO:0001837|GO:0006351|GO:0006355|GO:0048592|GO:0001738|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:0048593|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|digestive tract development|cellular aromatic compound metabolic process|tissue development|establishment of tissue polarity|cell development|tube development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|extracellular structure organization|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|reproductive structure development|RNA polymerase II transcription factor activity, sequence-specific DNA binding|sensory organ development|organ morphogenesis|transcription factor complex|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|sex differentiation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|transcription factor binding|cellular developmental process|genitalia development|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|palate development|cell morphogenesis|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|digestive system development|eye development|morphogenesis of an epithelium|reproductive system development|negative regulation of gene expression|regulation of RNA metabolic process|cell morphogenesis involved in differentiation|embryo development|establishment of planar polarity|positive regulation of gene expression|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|mesenchyme development|epithelium development|stem cell development|gene expression|embryonic organ morphogenesis|extracellular matrix organization|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|embryonic digestive tract development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|embryonic camera-type eye development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|stem cell differentiation|negative regulation of transcription, DNA-templated|camera-type eye development|establishment of planar polarity of embryonic epithelium|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|mesenchymal cell development|negative regulation of RNA biosynthetic process|embryonic eye morphogenesis|double-stranded DNA binding|mesenchymal cell differentiation|embryonic camera-type eye morphogenesis|epithelial to mesenchymal transition|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|morphogenesis of a polarized epithelium|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|camera-type eye morphogenesis|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 6:1389834-1395597 603 697 599 304 372 224 19.5035633999707 20.4884682093138 17.4678030612264 8.80984819860873 9.87207190011422 6.79005048016429 19.1532782235036 8.49065685962908 1.17364326717576 1.55074603945229e-07 2.28283886892548e-06 UP ENSG00000168779 SHOX2 short stature homeobox 2 [Source:HGNC Symbol;Acc:HGNC:10854] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0007507|GO:0008284|GO:0042127|GO:0048565|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:0051130|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0061061|GO:0045597|GO:0043231|GO:0001763|GO:0003170|GO:0060351|GO:0009887|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:1901863|GO:0001503|GO:0060348|GO:0060688|GO:0030030|GO:0048869|GO:0009967|GO:0044249|GO:0031324|GO:0031323|GO:0072089|GO:0003205|GO:0000902|GO:0031175|GO:0003677|GO:0048705|GO:0031344|GO:0051149|GO:0010468|GO:0034645|GO:0051216|GO:0055123|GO:0007166|GO:0072358|GO:0010629|GO:0010720|GO:2000172|GO:0042692|GO:0051252|GO:0002063|GO:0003007|GO:0010463|GO:0045880|GO:0008589|GO:0031346|GO:0000904|GO:0009790|GO:0010628|GO:0045844|GO:0051147|GO:0060537|GO:0001649|GO:0032330|GO:0050769|GO:0022604|GO:0003209|GO:0055001|GO:0035108|GO:0010467|GO:0032990|GO:0048562|GO:0007399|GO:0060349|GO:0060415|GO:0031328|GO:0010770|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0060173|GO:0061035|GO:0007517|GO:0048566|GO:0048546|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0051960|GO:2000648|GO:0048644|GO:0072091|GO:0016202|GO:0048755|GO:0048666|GO:0030182|GO:0055002|GO:0060538|GO:0048706|GO:0051153|GO:0045893|GO:0010975|GO:0009792|GO:0048641|GO:0010769|GO:0060350|GO:0045892|GO:0048742|GO:0002062|GO:0032774|GO:0048643|GO:0043565|GO:2001141|GO:0007224|GO:1902679|GO:0061564|GO:0048557|GO:0002053|GO:0048743|GO:0051146|GO:0035136|GO:0048704|GO:0014706|GO:0050772|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0030326|GO:0051155|GO:0010976|GO:0006351|GO:0006355|GO:0010464|GO:0045666|GO:0035115|GO:0045944|GO:0006366|GO:0010831|GO:1903507|GO:0006357|GO:0007409|GO:0048699|GO:0007519|GO:1903506|GO:0072498|GO:0060272|GO:0048747|GO:0014902|GO:0043009|GO:0010830|GO:0014904|GO:0000122|GO:0050770|GO:0045664|GO:0048741 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|heart development|positive regulation of cell proliferation|regulation of cell proliferation|digestive tract development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|morphogenesis of a branching structure|heart valve development|cartilage development involved in endochondral bone morphogenesis|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|positive regulation of muscle tissue development|ossification|bone development|regulation of morphogenesis of a branching structure|cell projection organization|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|stem cell proliferation|cardiac chamber development|cell morphogenesis|neuron projection development|DNA binding|skeletal system morphogenesis|regulation of cell projection organization|positive regulation of muscle cell differentiation|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|digestive system development|cell surface receptor signaling pathway|cardiovascular system development|negative regulation of gene expression|positive regulation of cell development|regulation of branching morphogenesis of a nerve|muscle cell differentiation|regulation of RNA metabolic process|chondrocyte development|heart morphogenesis|mesenchymal cell proliferation|positive regulation of smoothened signaling pathway|regulation of smoothened signaling pathway|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|positive regulation of striated muscle tissue development|regulation of muscle cell differentiation|muscle tissue development|osteoblast differentiation|regulation of chondrocyte differentiation|positive regulation of neurogenesis|regulation of cell morphogenesis|cardiac atrium morphogenesis|muscle cell development|limb morphogenesis|gene expression|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|bone morphogenesis|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|limb development|regulation of cartilage development|muscle organ development|embryonic digestive tract development|digestive tract morphogenesis|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|regulation of nervous system development|positive regulation of stem cell proliferation|muscle organ morphogenesis|regulation of stem cell proliferation|regulation of striated muscle tissue development|branching morphogenesis of a nerve|neuron development|neuron differentiation|striated muscle cell development|skeletal muscle organ development|embryonic skeletal system development|regulation of striated muscle cell differentiation|positive regulation of transcription, DNA-templated|regulation of neuron projection development|embryo development ending in birth or egg hatching|regulation of skeletal muscle tissue development|regulation of cell morphogenesis involved in differentiation|endochondral bone morphogenesis|negative regulation of transcription, DNA-templated|regulation of skeletal muscle fiber development|chondrocyte differentiation|RNA biosynthetic process|positive regulation of skeletal muscle tissue development|sequence-specific DNA binding|regulation of RNA biosynthetic process|smoothened signaling pathway|negative regulation of RNA biosynthetic process|axon development|embryonic digestive tract morphogenesis|positive regulation of mesenchymal cell proliferation|positive regulation of skeletal muscle fiber development|striated muscle cell differentiation|forelimb morphogenesis|embryonic skeletal system morphogenesis|striated muscle tissue development|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|embryonic limb morphogenesis|positive regulation of striated muscle cell differentiation|positive regulation of neuron projection development|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of mesenchymal cell proliferation|positive regulation of neuron differentiation|embryonic forelimb morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|positive regulation of myotube differentiation|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|embryonic skeletal joint development|embryonic skeletal joint morphogenesis|muscle fiber development|myotube differentiation|chordate embryonic development|regulation of myotube differentiation|myotube cell development|negative regulation of transcription from RNA polymerase II promoter|regulation of axonogenesis|regulation of neuron differentiation|skeletal muscle fiber development - - - - 3:158095954-158106503 149 206 184 64 90 67 0.883618195539347 1.11026024717374 0.983805149700419 0.340060892891795 0.437912789234014 0.372376682956936 0.992561197471169 0.383450121694248 1.37211712847945 1.58353304008128e-07 2.32995541540595e-06 UP ENSG00000174136 RGMB repulsive guidance molecule family member b [Source:HGNC Symbol;Acc:HGNC:26896] GO:0040011|GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0038023|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0031225|GO:0042802|GO:0006935|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0034641|GO:0046658|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0006928|GO:0006139|GO:0031226|GO:0007154|GO:0007165|GO:0030030|GO:0015026|GO:0048869|GO:0044249|GO:0010033|GO:0098857|GO:0031323|GO:0000902|GO:0031175|GO:0010468|GO:0071773|GO:0034645|GO:0007166|GO:0005793|GO:0051252|GO:0000904|GO:0010628|GO:0070848|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0031328|GO:0009059|GO:0030154|GO:0048858|GO:0045121|GO:0016070|GO:0010557|GO:0048666|GO:0030182|GO:0007411|GO:0045893|GO:0032774|GO:2001141|GO:0071363|GO:0061564|GO:0030509|GO:0007167|GO:0022008|GO:0048667|GO:0048812|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:0007409|GO:0048699|GO:1903506|GO:0007178 locomotion|developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|signaling receptor activity|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|anchored component of membrane|identical protein binding|chemotaxis|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|anchored component of plasma membrane|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|cell communication|signal transduction|cell projection organization|coreceptor activity|cellular developmental process|cellular biosynthetic process|response to organic substance|membrane microdomain|regulation of cellular metabolic process|cell morphogenesis|neuron projection development|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|endoplasmic reticulum-Golgi intermediate compartment|regulation of RNA metabolic process|cell morphogenesis involved in differentiation|positive regulation of gene expression|response to growth factor|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|membrane raft|RNA metabolic process|positive regulation of macromolecule biosynthetic process|neuron development|neuron differentiation|axon guidance|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|axon development|BMP signaling pathway|enzyme linked receptor protein signaling pathway|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway - - - - 5:98768650-98798643 490 801 787 307 347 365 3.48317114936935 5.17477843827839 5.04391772972723 1.95530584957007 2.02383898798415 2.43164800353074 4.56728910579166 2.13693094702832 1.0957978246844 1.59168679369947e-07 2.34079889355193e-06 UP ENSG00000148291 SURF2 surfeit 2 [Source:HGNC Symbol;Acc:HGNC:11475] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0043231|GO:0005730|GO:0031981|GO:0005634 cell|membrane|intracellular organelle|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|intracellular membrane-bounded organelle|nucleolus|nuclear lumen|nucleus - - - - 9:133356552-133361169 678 704 423 260 252 130 29.5317786644818 27.8684245769585 16.6117088281377 10.1468255011506 9.00591017501422 5.30677626253656 24.670637356526 8.15317064623379 1.59736187147796 1.59577699777789e-07 2.34565861603452e-06 UP ENSG00000215158 RP11-1023L17.1 - - - - - - - 5:34164698-34244796 7 7 22 42 79 89 0.0723401126532658 0.0657474856408117 0.204974491683559 0.388887025752376 0.669834748473355 0.861973268498368 0.114354029992546 0.640231680908033 -2.48508685906464 1.60423030059017e-07 2.3569237890659e-06 DOWN ENSG00000141699 FAM134C family with sequence similarity 134 member C [Source:HGNC Symbol;Acc:HGNC:27258] GO:0032502|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0016043|GO:0031224|GO:0050793|GO:0005515|GO:0048856|GO:0045595|GO:0048468|GO:0051130|GO:0007275|GO:0051128|GO:0045597|GO:0030030|GO:0048869|GO:0016021|GO:0031175|GO:0031344|GO:0010720|GO:0031346|GO:0050769|GO:0007399|GO:0030154|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0022008|GO:0050767|GO:0010976|GO:0045666|GO:0048699|GO:0045664 developmental process|membrane|cellular process|binding|regulation of cellular process|cellular component organization|intrinsic component of membrane|regulation of developmental process|protein binding|anatomical structure development|regulation of cell differentiation|cell development|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component organization|positive regulation of cell differentiation|cell projection organization|cellular developmental process|integral component of membrane|neuron projection development|regulation of cell projection organization|positive regulation of cell development|positive regulation of cell projection organization|positive regulation of neurogenesis|nervous system development|cell differentiation|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|positive regulation of neuron differentiation|generation of neurons|regulation of neuron differentiation - - - - 17:42579513-42610623 1082 1188 936 569 611 469 6.75587370475373 6.74141023643446 5.26919599759801 3.18320407329562 3.13013912430664 2.74445167300043 6.25549331292873 3.01926495686756 1.05092629418056 1.60754792810124e-07 2.36063629343504e-06 UP ENSG00000268006 PTOV1-AS1 PTOV1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44174] - - - - - - 19:49838639-49851676 894 1007 788 484 463 441 11.8513344747772 12.1321972390548 9.41824775231175 5.74874564661081 5.03591643586367 5.47895063391952 11.1339264887146 5.421204238798 1.03827719776783 1.61653655272332e-07 2.37266874360875e-06 UP ENSG00000138018 EPT1 ethanolaminephosphotransferase 1 [Source:HGNC Symbol;Acc:HGNC:29361] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0051050|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:1903829|GO:0012505|GO:0016740|GO:0031090|GO:0060341|GO:0044255|GO:0006810|GO:0051130|GO:0044281|GO:0016772|GO:0019637|GO:0051128|GO:0043231|GO:0043169|GO:0005737|GO:0032880|GO:0051222|GO:0045184|GO:0032388|GO:0008104|GO:0006629|GO:0005783|GO:0051649|GO:0090316|GO:0016021|GO:0044249|GO:0006996|GO:0008654|GO:0046486|GO:0046872|GO:0072594|GO:0007005|GO:0032386|GO:0051223|GO:1903955|GO:0015031|GO:0016780|GO:0070201|GO:0046907|GO:0034613|GO:0006796|GO:0033043|GO:0008610|GO:0006626|GO:1903827|GO:0006644|GO:0010638|GO:0033365|GO:0033157|GO:0046474|GO:0006839|GO:0006605|GO:0072655|GO:0010822|GO:0016482|GO:0006886|GO:0010821|GO:1903214|GO:0006650|GO:0004307|GO:1903533|GO:0006646|GO:0046337|GO:0070585 cell|membrane|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|positive regulation of transport|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|positive regulation of cellular protein localization|endomembrane system|transferase activity|organelle membrane|regulation of cellular localization|cellular lipid metabolic process|transport|positive regulation of cellular component organization|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|cytoplasm|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|positive regulation of intracellular transport|protein localization|lipid metabolic process|endoplasmic reticulum|establishment of localization in cell|positive regulation of intracellular protein transport|integral component of membrane|cellular biosynthetic process|organelle organization|phospholipid biosynthetic process|glycerolipid metabolic process|metal ion binding|establishment of protein localization to organelle|mitochondrion organization|regulation of intracellular transport|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|phosphotransferase activity, for other substituted phosphate groups|regulation of establishment of protein localization|intracellular transport|cellular protein localization|phosphate-containing compound metabolic process|regulation of organelle organization|lipid biosynthetic process|protein targeting to mitochondrion|regulation of cellular protein localization|phospholipid metabolic process|positive regulation of organelle organization|protein localization to organelle|regulation of intracellular protein transport|glycerophospholipid biosynthetic process|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|regulation of protein targeting to mitochondrion|glycerophospholipid metabolic process|ethanolaminephosphotransferase activity|regulation of protein targeting|phosphatidylethanolamine biosynthetic process|phosphatidylethanolamine metabolic process|protein localization to mitochondrion K00993 ethanolaminephosphotransferase[2.7.8.1] hsa01100|hsa00564|hsa00565 Metabolic pathways - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Ether lipid metabolism - Homo sapiens (human) 2:26308547-26395891 964 1261 1234 2707 3084 2229 4.26056452405987 5.06506586664669 4.91721630521578 10.7195354769454 11.1833609794478 9.23270680114273 4.74761556530745 10.3785344191786 -1.12832770757538 1.62747971939623e-07 2.38552929343788e-06 DOWN ENSG00000186625 KATNA1 katanin p60 (ATPase containing) subunit A 1 [Source:HGNC Symbol;Acc:HGNC:6216] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0030496|GO:0042995|GO:0097159|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0043167|GO:0044297|GO:0016043|GO:0030427|GO:0043227|GO:0016787|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0007049|GO:0045595|GO:0048468|GO:0043025|GO:0022402|GO:0007275|GO:0045596|GO:0043168|GO:0005874|GO:0001882|GO:0051128|GO:0030426|GO:0016817|GO:0043231|GO:0005737|GO:0032403|GO:0043005|GO:0046983|GO:0036477|GO:0008092|GO:0000166|GO:0030030|GO:0051301|GO:0048869|GO:0007017|GO:0006996|GO:0050768|GO:0015631|GO:0031175|GO:0005813|GO:0031344|GO:0035639|GO:1903047|GO:0030424|GO:0046982|GO:0005815|GO:0001883|GO:0010721|GO:0008017|GO:0016818|GO:0000278|GO:0032549|GO:0031345|GO:0051013|GO:0007067|GO:0007399|GO:0017076|GO:0030154|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0005524|GO:0030554|GO:0015630|GO:0045665|GO:0022008|GO:0050767|GO:0016462|GO:0010977|GO:0048699|GO:0017111|GO:0045664|GO:0016887|GO:0042623|GO:0008568 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|midbody|cell projection|organic cyclic compound binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|ion binding|cell body|cellular component organization|site of polarized growth|membrane-bounded organelle|hydrolase activity|regulation of developmental process|intracellular|protein binding|anatomical structure development|cell cycle|regulation of cell differentiation|cell development|neuronal cell body|cell cycle process|multicellular organism development|negative regulation of cell differentiation|anion binding|microtubule|nucleoside binding|regulation of cellular component organization|growth cone|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|protein complex binding|neuron projection|protein dimerization activity|somatodendritic compartment|cytoskeletal protein binding|nucleotide binding|cell projection organization|cell division|cellular developmental process|microtubule-based process|organelle organization|negative regulation of neurogenesis|tubulin binding|neuron projection development|centrosome|regulation of cell projection organization|purine ribonucleoside triphosphate binding|mitotic cell cycle process|axon|protein heterodimerization activity|microtubule organizing center|purine nucleoside binding|negative regulation of cell development|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|ribonucleoside binding|negative regulation of cell projection organization|microtubule severing|mitotic nuclear division|nervous system development|purine nucleotide binding|cell differentiation|cytoskeleton|spindle pole|nucleus|spindle|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|negative regulation of neuron differentiation|neurogenesis|regulation of neurogenesis|pyrophosphatase activity|negative regulation of neuron projection development|generation of neurons|nucleoside-triphosphatase activity|regulation of neuron differentiation|ATPase activity|ATPase activity, coupled|microtubule-severing ATPase activity - - - - 6:149594873-149648972 615 616 620 323 332 313 10.4149298951551 9.48073711515981 9.4664570296041 4.90096771625117 4.6130429028268 4.96769150658143 9.787374679973 4.82723404188647 1.01972515430095 1.62769584334862e-07 2.38552929343788e-06 UP ENSG00000136819 C9orf78 chromosome 9 open reading frame 78 [Source:HGNC Symbol;Acc:HGNC:24932] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nuclear lumen|nucleoplasm|nucleus - - - - 9:129827290-129835863 1920 1982 1706 959 1128 745 16.5305179711079 15.5084731339658 13.2427645174703 7.39778699200037 7.96824169176826 6.01132981748239 15.093918540848 7.12578616708367 1.08284629700712 1.63413788870327e-07 2.39379551174423e-06 UP ENSG00000151849 CENPJ centromere protein J [Source:HGNC Symbol;Acc:HGNC:17272] GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0016043|GO:0005622|GO:0005515|GO:0043234|GO:0051726|GO:0007049|GO:1902115|GO:0000930|GO:0022402|GO:0005874|GO:0051128|GO:0022607|GO:0019899|GO:0005737|GO:0032886|GO:0019904|GO:0008092|GO:0051301|GO:0007017|GO:0006996|GO:0031023|GO:0015631|GO:0005829|GO:0005813|GO:1903047|GO:0007010|GO:0070507|GO:0005815|GO:0044770|GO:0007098|GO:0098534|GO:0005814|GO:0000278|GO:0046599|GO:0010564|GO:0007099|GO:0006461|GO:0070925|GO:0019900|GO:0008275|GO:0033043|GO:0051298|GO:0000226|GO:0005856|GO:0034622|GO:0000086|GO:0044772|GO:0043623|GO:0051493|GO:0015630|GO:0007020|GO:0031109|GO:0051297|GO:0010824|GO:0046605|GO:0019901|GO:0051258|GO:0046785 macromolecular complex|cell|cellular process|binding|regulation of cellular process|intracellular organelle|cellular component organization|intracellular|protein binding|protein complex|regulation of cell cycle|cell cycle|regulation of organelle assembly|gamma-tubulin complex|cell cycle process|microtubule|regulation of cellular component organization|cellular component assembly|enzyme binding|cytoplasm|regulation of microtubule-based process|protein domain specific binding|cytoskeletal protein binding|cell division|microtubule-based process|organelle organization|microtubule organizing center organization|tubulin binding|cytosol|centrosome|mitotic cell cycle process|cytoskeleton organization|regulation of microtubule cytoskeleton organization|microtubule organizing center|cell cycle phase transition|centrosome cycle|centriole assembly|centriole|mitotic cell cycle|regulation of centriole replication|regulation of cell cycle process|centriole replication|protein complex assembly|organelle assembly|kinase binding|gamma-tubulin small complex|regulation of organelle organization|centrosome duplication|microtubule cytoskeleton organization|cytoskeleton|cellular macromolecular complex assembly|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|cellular protein complex assembly|regulation of cytoskeleton organization|microtubule cytoskeleton|microtubule nucleation|microtubule polymerization or depolymerization|centrosome organization|regulation of centrosome duplication|regulation of centrosome cycle|protein kinase binding|protein polymerization|microtubule polymerization - - - - 13:24882284-24922889 249 327 330 678 758 679 2.45758133611753 2.93316285817128 2.93654571955987 5.99563880962144 6.13826159171731 6.28068403118498 2.77576330461623 6.13819481084124 -1.14492988262536 1.63875300522012e-07 2.39937872574014e-06 DOWN ENSG00000203778 FAM229B family with sequence similarity 229 member B [Source:HGNC Symbol;Acc:HGNC:33858] - - - - - - 6:112087599-112102790 19 20 37 85 99 88 0.47306259292136 0.452568124456666 0.830607022070233 1.89623800635369 2.02244291194888 2.05344975738937 0.585412579816086 1.99071022523065 -1.7657575796031 1.64799531764612e-07 2.41172804965722e-06 DOWN ENSG00000103226 NOMO3 NODAL modulator 3 [Source:HGNC Symbol;Acc:HGNC:25242] GO:0016020|GO:0005488|GO:0030246|GO:0031224|GO:0016021 membrane|binding|carbohydrate binding|intrinsic component of membrane|integral component of membrane - - - - 16:16232495-16294814 509 458 691 1128 1471 1342 2.94255256577418 2.406312945532 3.60162355618982 5.8426908506417 6.97729313839153 7.27089015556237 2.983496355832 6.69695804819853 -1.16650191586821 1.66020327140113e-07 2.42840315847179e-06 DOWN ENSG00000168393 DTYMK deoxythymidylate kinase [Source:HGNC Symbol;Acc:HGNC:3061] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0016740|GO:0048856|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0061061|GO:0043231|GO:0005737|GO:0005758|GO:0006139|GO:0055086|GO:0009725|GO:0000166|GO:0048869|GO:0010035|GO:0044249|GO:0010033|GO:0005740|GO:0005829|GO:0009262|GO:0033993|GO:0035639|GO:0015949|GO:0042692|GO:0001883|GO:0010038|GO:0032549|GO:0070848|GO:0005759|GO:0005739|GO:0016301|GO:0014070|GO:0006796|GO:1901137|GO:0071310|GO:0017076|GO:0030154|GO:0048545|GO:0016776|GO:0009142|GO:0009041|GO:0045445|GO:0046686|GO:0009117|GO:0009133|GO:0006220|GO:0005524|GO:0071363|GO:0030554|GO:0016310|GO:0043627|GO:0019205|GO:0009132|GO:0009263|GO:0050145|GO:0004798|GO:0009165|GO:0046939|GO:0046940|GO:0009200|GO:0019201|GO:0009186|GO:0006221|GO:0006235|GO:0006233|GO:0006227 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|transferase activity|anatomical structure development|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|cytoplasm|mitochondrial intermembrane space|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|response to hormone|nucleotide binding|cellular developmental process|response to inorganic substance|cellular biosynthetic process|response to organic substance|mitochondrial envelope|cytosol|deoxyribonucleotide metabolic process|response to lipid|purine ribonucleoside triphosphate binding|nucleobase-containing small molecule interconversion|muscle cell differentiation|purine nucleoside binding|response to metal ion|ribonucleoside binding|response to growth factor|mitochondrial matrix|mitochondrion|kinase activity|response to organic cyclic compound|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular response to organic substance|purine nucleotide binding|cell differentiation|response to steroid hormone|phosphotransferase activity, phosphate group as acceptor|nucleoside triphosphate biosynthetic process|uridylate kinase activity|myoblast differentiation|response to cadmium ion|nucleotide metabolic process|nucleoside diphosphate biosynthetic process|pyrimidine nucleotide metabolic process|ATP binding|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|response to estrogen|nucleobase-containing compound kinase activity|nucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|nucleoside phosphate kinase activity|thymidylate kinase activity|nucleotide biosynthetic process|nucleotide phosphorylation|nucleoside monophosphate phosphorylation|deoxyribonucleoside triphosphate metabolic process|nucleotide kinase activity|deoxyribonucleoside diphosphate metabolic process|pyrimidine nucleotide biosynthetic process|dTTP biosynthetic process|dTDP biosynthetic process|dUDP biosynthetic process K00943 dTMP kinase[2.7.4.9] hsa01100|hsa00240 Metabolic pathways - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human) 2:241675742-241686991 477 538 519 1433 1542 931 7.97105283689436 8.17071329266599 7.81950735456475 21.4556381220227 21.1421795979284 14.5806250387904 7.98709116137503 19.0594809195805 -1.25476674310845 1.67160638373145e-07 2.44268903474884e-06 DOWN ENSG00000154930 ACSS1 acyl-CoA synthetase short-chain family member 1 [Source:HGNC Symbol;Acc:HGNC:16091] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0044255|GO:0006082|GO:0009410|GO:0043168|GO:0044281|GO:0001882|GO:0043231|GO:0043169|GO:0005737|GO:0051186|GO:0006629|GO:0006805|GO:0000166|GO:0044249|GO:0006790|GO:0055114|GO:0006069|GO:0035639|GO:0016208|GO:0006637|GO:0006066|GO:0006631|GO:0001883|GO:0032549|GO:0071466|GO:0016878|GO:0005759|GO:0005739|GO:0019427|GO:0008610|GO:0017076|GO:0005524|GO:0003987|GO:0030554|GO:0046459|GO:0009108|GO:0006633|GO:0019752|GO:0006084|GO:0006067|GO:0006085|GO:0032787|GO:0051790|GO:0019413|GO:0019542|GO:0006083 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|protein binding|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|anion binding|small molecule metabolic process|nucleoside binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|cofactor metabolic process|lipid metabolic process|xenobiotic metabolic process|nucleotide binding|cellular biosynthetic process|sulfur compound metabolic process|oxidation-reduction process|ethanol oxidation|purine ribonucleoside triphosphate binding|AMP binding|acyl-CoA metabolic process|alcohol metabolic process|fatty acid metabolic process|purine nucleoside binding|ribonucleoside binding|cellular response to xenobiotic stimulus|acid-thiol ligase activity|mitochondrial matrix|mitochondrion|acetyl-CoA biosynthetic process from acetate|lipid biosynthetic process|purine nucleotide binding|ATP binding|acetate-CoA ligase activity|adenyl nucleotide binding|short-chain fatty acid metabolic process|coenzyme biosynthetic process|fatty acid biosynthetic process|carboxylic acid metabolic process|acetyl-CoA metabolic process|ethanol metabolic process|acetyl-CoA biosynthetic process|monocarboxylic acid metabolic process|short-chain fatty acid biosynthetic process|acetate biosynthetic process|propionate biosynthetic process|acetate metabolic process K01895 acetyl-CoA synthetase[6.2.1.1] hsa01100|hsa01200|hsa00010|hsa00620|hsa00640 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human)|Pyruvate metabolism - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human) 20:25006230-25058980 141 148 250 449 465 574 0.85152645204542 0.812304337718969 1.36123217869512 2.42952899397201 2.30408747177813 3.2487674366804 1.00835432281984 2.66079463414351 -1.39985449182691 1.68002408115195e-07 2.45378859680579e-06 DOWN ENSG00000088247 KHSRP KH-type splicing regulatory protein [Source:HGNC Symbol;Acc:HGNC:6316] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0044297|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:0043025|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0030529|GO:0043005|GO:0036477|GO:0006139|GO:0006403|GO:0044249|GO:0043487|GO:0031323|GO:0035770|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0003723|GO:0051252|GO:0044265|GO:0031981|GO:0030425|GO:0005654|GO:0050658|GO:0010467|GO:0019439|GO:0009059|GO:0016070|GO:0005634|GO:0036464|GO:0043488|GO:0006401|GO:2000628|GO:0051028|GO:0006396|GO:0032774|GO:0034660|GO:2001141|GO:0010608|GO:0016071|GO:0044822|GO:0010494|GO:0006351|GO:0006355|GO:0003729|GO:1903506|GO:0006402|GO:0006397|GO:0008380|GO:0010586|GO:0000375|GO:0003730 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cell body|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|neuronal cell body|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|neuron projection|somatodendritic compartment|nucleobase-containing compound metabolic process|RNA localization|cellular biosynthetic process|regulation of RNA stability|regulation of cellular metabolic process|ribonucleoprotein granule|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|regulation of RNA metabolic process|cellular macromolecule catabolic process|nuclear lumen|dendrite|nucleoplasm|RNA transport|gene expression|aromatic compound catabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|RNA catabolic process|regulation of miRNA metabolic process|mRNA transport|RNA processing|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|mRNA metabolic process|poly(A) RNA binding|cytoplasmic stress granule|transcription, DNA-templated|regulation of transcription, DNA-templated|mRNA binding|regulation of nucleic acid-templated transcription|mRNA catabolic process|mRNA processing|RNA splicing|miRNA metabolic process|RNA splicing, via transesterification reactions|mRNA 3'-UTR binding - - - - 19:6413348-6424794 5843 6100 4648 2636 3294 2088 53.2074481348846 50.4831397369786 38.1607504660201 21.5069882941499 24.6109345194866 17.8195138348705 47.2837794459611 21.3124788828357 1.14964695170663 1.68555469890126e-07 2.46066259075785e-06 UP ENSG00000070814 TCOF1 Treacher Collins-Franceschetti syndrome 1 [Source:HGNC Symbol;Acc:HGNC:11654] GO:0032502|GO:0005215|GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0006810|GO:0007275|GO:0003676|GO:0043231|GO:0005737|GO:0005730|GO:0003723|GO:0031981|GO:0001501|GO:0005634|GO:0044822 developmental process|transporter activity|cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|transport|multicellular organism development|nucleic acid binding|intracellular membrane-bounded organelle|cytoplasm|nucleolus|RNA binding|nuclear lumen|skeletal system development|nucleus|poly(A) RNA binding K14562 Treacher Collins syndrome protein[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 5:150357639-150400308 6000 6077 5107 2825 3168 1581 23.6604484029302 21.7791533032495 18.1573234407664 9.98131616920893 10.2500229247734 5.84295629805427 21.198975048982 8.69143179734553 1.286328747015 1.69312970622396e-07 2.47051291542572e-06 UP ENSG00000145416 MARCH1 membrane associated ring-CH-type finger 1 [Source:HGNC Symbol;Acc:HGNC:26077] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0019882|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0043227|GO:0071944|GO:0031224|GO:0016874|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0031090|GO:0005102|GO:0031982|GO:0043231|GO:0043169|GO:0005774|GO:0005737|GO:0012506|GO:0005783|GO:0002504|GO:0019787|GO:0010008|GO:0048002|GO:0016021|GO:0019538|GO:0005794|GO:0005768|GO:0005802|GO:0046872|GO:0043412|GO:0031410|GO:0004842|GO:0005769|GO:0005773|GO:0016023|GO:0036211|GO:0042287|GO:0005770|GO:0031988|GO:0031901|GO:0030659|GO:0044267|GO:0000139|GO:0031902|GO:0002495|GO:0061630|GO:0000323|GO:0046914|GO:0006464|GO:0032588|GO:0005765|GO:0005764|GO:0008270|GO:0032446|GO:0016567|GO:0000209 immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|antigen processing and presentation|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|immune response|cellular metabolic process|membrane-bounded organelle|cell periphery|intrinsic component of membrane|ligase activity|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|transferase activity|organelle membrane|receptor binding|vesicle|intracellular membrane-bounded organelle|cation binding|vacuolar membrane|cytoplasm|vesicle membrane|endoplasmic reticulum|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|ubiquitin-like protein transferase activity|endosome membrane|antigen processing and presentation of peptide antigen|integral component of membrane|protein metabolic process|Golgi apparatus|endosome|trans-Golgi network|metal ion binding|macromolecule modification|cytoplasmic vesicle|ubiquitin-protein transferase activity|early endosome|vacuole|cytoplasmic, membrane-bounded vesicle|protein modification process|MHC protein binding|late endosome|membrane-bounded vesicle|early endosome membrane|cytoplasmic vesicle membrane|cellular protein metabolic process|Golgi membrane|late endosome membrane|antigen processing and presentation of peptide antigen via MHC class II|ubiquitin protein ligase activity|lytic vacuole|transition metal ion binding|cellular protein modification process|trans-Golgi network membrane|lysosomal membrane|lysosome|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination|protein polyubiquitination - - - - 4:163524298-164384050 61 72 108 220 238 239 0.185104854067145 0.198562298901506 0.295475499574615 0.598144169963507 0.592555517401045 0.679690601616656 0.226380884181089 0.623463429660403 -1.46155279797149 1.6944727679303e-07 2.47126477839723e-06 DOWN ENSG00000229719 MIR194-2HG MIR194-2 host gene [Source:HGNC Symbol;Acc:HGNC:51946] - - - - - - 11:64889560-64893449 14 14 13 0 1 2 0.271548160741214 0.246784269017541 0.227332410688348 0 0.0159208191895674 0.0363508337689707 0.248554946815701 0.0174238843195127 3.83442663053447 1.70304090610605e-07 2.48254800834424e-06 UP ENSG00000273514 FOXD4L6 forkhead box D4-like 6 [Source:HGNC Symbol;Acc:HGNC:31986] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 9:41126430-41128463 44 35 10 2 4 2 1.53019139214211 1.10623697021893 0.313559744329958 0.0623213889939378 0.114128155181683 0.0651777240685527 0.983329368896999 0.0805424227480578 3.6098539573274 1.70413763340915e-07 2.48293435372362e-06 UP ENSG00000135114 OASL 2'-5'-oligoadenylate synthetase-like [Source:HGNC Symbol;Acc:HGNC:8090] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0043167|GO:0006955|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0005515|GO:0016740|GO:0016032|GO:0045087|GO:0003676|GO:0005102|GO:0043168|GO:0006952|GO:0001882|GO:0098542|GO:0043231|GO:0005737|GO:0009615|GO:0007154|GO:0007165|GO:0008134|GO:0048525|GO:0051607|GO:0000166|GO:0050792|GO:0010033|GO:0005730|GO:0005829|GO:0003677|GO:0034340|GO:0003723|GO:0007166|GO:0035639|GO:0034097|GO:0051427|GO:0001883|GO:0032549|GO:0034341|GO:0031981|GO:0046966|GO:0019079|GO:0019058|GO:0071310|GO:0017076|GO:0005634|GO:0019221|GO:0071346|GO:0005524|GO:0035257|GO:0030554|GO:0071357|GO:0045069|GO:0003725|GO:0045071|GO:0071345|GO:0044822|GO:0060333|GO:0060337 immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|ion binding|immune response|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|protein binding|transferase activity|viral process|innate immune response|nucleic acid binding|receptor binding|anion binding|defense response|nucleoside binding|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|response to virus|cell communication|signal transduction|transcription factor binding|negative regulation of viral process|defense response to virus|nucleotide binding|regulation of viral process|response to organic substance|nucleolus|cytosol|DNA binding|response to type I interferon|RNA binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|response to cytokine|hormone receptor binding|purine nucleoside binding|ribonucleoside binding|response to interferon-gamma|nuclear lumen|thyroid hormone receptor binding|viral genome replication|viral life cycle|cellular response to organic substance|purine nucleotide binding|nucleus|cytokine-mediated signaling pathway|cellular response to interferon-gamma|ATP binding|nuclear hormone receptor binding|adenyl nucleotide binding|cellular response to type I interferon|regulation of viral genome replication|double-stranded RNA binding|negative regulation of viral genome replication|cellular response to cytokine stimulus|poly(A) RNA binding|interferon-gamma-mediated signaling pathway|type I interferon signaling pathway - - - - 12:121019111-121039242 57 98 74 19 27 26 0.734288606887207 1.14736033577651 0.859486860507981 0.219305070191921 0.285377834381773 0.313902919335618 0.913711934390566 0.272861941303104 1.74356821705876 1.70871211229641e-07 2.48838494636571e-06 UP ENSG00000100564 PIGH phosphatidylinositol glycan anchor biosynthesis class H [Source:HGNC Symbol;Acc:HGNC:8964] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0000506|GO:0044255|GO:0019637|GO:0043231|GO:0005737|GO:0006629|GO:0005783|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0008654|GO:0034645|GO:0046486|GO:0043412|GO:0008194|GO:0006643|GO:0036211|GO:0016758|GO:0042157|GO:0006796|GO:1901137|GO:0044267|GO:0008610|GO:0009059|GO:0006644|GO:0046474|GO:0008375|GO:0009247|GO:0006664|GO:0042158|GO:0006464|GO:0006650|GO:0016254|GO:0006506|GO:0046488|GO:0017176|GO:0006661|GO:0006505|GO:0043687|GO:0006497|GO:0006501 macromolecular complex|cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein complex|endomembrane system|transferase activity|organelle membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|cellular lipid metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|glycerolipid metabolic process|macromolecule modification|UDP-glycosyltransferase activity|membrane lipid metabolic process|protein modification process|transferase activity, transferring hexosyl groups|lipoprotein metabolic process|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|lipid biosynthetic process|macromolecule biosynthetic process|phospholipid metabolic process|glycerophospholipid biosynthetic process|acetylglucosaminyltransferase activity|glycolipid biosynthetic process|glycolipid metabolic process|lipoprotein biosynthetic process|cellular protein modification process|glycerophospholipid metabolic process|preassembly of GPI anchor in ER membrane|GPI anchor biosynthetic process|phosphatidylinositol metabolic process|phosphatidylinositol N-acetylglucosaminyltransferase activity|phosphatidylinositol biosynthetic process|GPI anchor metabolic process|post-translational protein modification|protein lipidation|C-terminal protein lipidation K03858 phosphatidylinositol glycan, class H[-] hsa01100|hsa00563 Metabolic pathways - Homo sapiens (human)|Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human) 14:67581955-67600287 413 486 527 215 271 233 3.81587249830781 4.08094170059346 4.39003817913957 1.77983312746593 2.05438015641775 2.01757486181029 4.09561745934695 1.95059604856466 1.07016593108328 1.71502118926354e-07 2.49635507480613e-06 UP ENSG00000259803 SLC22A31 solute carrier family 22 member 31 [Source:HGNC Symbol;Acc:HGNC:27091] GO:0005215|GO:0016020|GO:0009987|GO:0022857|GO:0031224|GO:0006810|GO:0055085|GO:0016021 transporter activity|membrane|cellular process|transmembrane transporter activity|intrinsic component of membrane|transport|transmembrane transport|integral component of membrane - - - - 16:89195761-89201664 30 31 55 106 142 191 0.559028753791847 0.525009691546107 0.924049720044425 1.76978764580514 2.17108348648396 3.3356689284519 0.669362721794126 2.42551335358033 -1.85743001058362 1.74935563970592e-07 2.54385110900052e-06 DOWN ENSG00000138400 MDH1B malate dehydrogenase 1B [Source:HGNC Symbol;Acc:HGNC:17836] GO:0009987|GO:0008152|GO:0003824|GO:0016491|GO:0071704|GO:0044237|GO:0006082|GO:0015980|GO:0044281|GO:0016614|GO:0005975|GO:0006099|GO:0006091|GO:0055114|GO:0016616|GO:0045333|GO:0016615|GO:0009060|GO:0019752|GO:0072350|GO:0043648|GO:0006101|GO:0006108 cellular process|metabolic process|catalytic activity|oxidoreductase activity|organic substance metabolic process|cellular metabolic process|organic acid metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|carbohydrate metabolic process|tricarboxylic acid cycle|generation of precursor metabolites and energy|oxidation-reduction process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|cellular respiration|malate dehydrogenase activity|aerobic respiration|carboxylic acid metabolic process|tricarboxylic acid metabolic process|dicarboxylic acid metabolic process|citrate metabolic process|malate metabolic process - - - - 2:206737763-206765547 4 7 4 27 34 30 0.0566548361619263 0.0901164475793665 0.0510837420878763 0.342661385918805 0.395129739213853 0.398248784207679 0.0659516752763897 0.378679969780112 -2.5214979003235 1.75436567948899e-07 2.54865367374523e-06 DOWN ENSG00000169592 INO80E INO80 complex subunit E [Source:HGNC Symbol;Acc:HGNC:26905] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0000785|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006281|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0070603|GO:0043231|GO:0006139|GO:0000790|GO:0044249|GO:0031323|GO:0005730|GO:0010468|GO:0034645|GO:0051252|GO:0031011|GO:0031981|GO:0006259|GO:0005694|GO:0000228|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006974|GO:0006260|GO:0032774|GO:2001141|GO:0006310|GO:0006351|GO:0006355|GO:1903506 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|chromatin|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nuclear chromatin|cellular biosynthetic process|regulation of cellular metabolic process|nucleolus|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|Ino80 complex|nuclear lumen|DNA metabolic process|chromosome|nuclear chromosome|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|DNA replication|RNA biosynthetic process|regulation of RNA biosynthetic process|DNA recombination|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 16:29995294-30005793 930 847 856 467 519 338 4.49475686973509 3.72037688814877 3.73002260137731 2.02226457605255 2.05806203430704 1.5309785875707 3.98171878642039 1.87043506597676 1.09001745046222 1.75393573557657e-07 2.54865367374523e-06 UP ENSG00000172264 MACROD2 MACRO domain containing 2 [Source:HGNC Symbol;Acc:HGNC:16126] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0048856|GO:0006725|GO:1901360|GO:0007275|GO:0048513|GO:0016798|GO:0034641|GO:0044281|GO:0046483|GO:0033554|GO:0007420|GO:0043231|GO:0019213|GO:0060322|GO:0006139|GO:0055086|GO:0019538|GO:0043412|GO:0007417|GO:0036211|GO:0009116|GO:0044267|GO:0007399|GO:0005634|GO:0006974|GO:0006464|GO:0042278|GO:0051725 developmental process|cell|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|anatomical structure development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|hydrolase activity, acting on glycosyl bonds|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|cellular response to stress|brain development|intracellular membrane-bounded organelle|deacetylase activity|head development|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein metabolic process|macromolecule modification|central nervous system development|protein modification process|nucleoside metabolic process|cellular protein metabolic process|nervous system development|nucleus|cellular response to DNA damage stimulus|cellular protein modification process|purine nucleoside metabolic process|protein de-ADP-ribosylation - - - - 20:13995369-16053197 8 10 16 36 68 112 0.0411331324842132 0.0467306113826194 0.0741766978227387 0.165853498265174 0.286880421357629 0.539719430112645 0.0540134805631904 0.330817783245149 -2.6146453673383 1.76113488434437e-07 2.55724323138214e-06 DOWN ENSG00000087269 NOP14 NOP14 nucleolar protein [Source:HGNC Symbol;Acc:HGNC:16821] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0030529|GO:0006139|GO:0022613|GO:0005730|GO:0003723|GO:0030684|GO:0042254|GO:0031981|GO:0030692|GO:0005739|GO:0042274|GO:0010467|GO:0016070|GO:0005634|GO:0006364|GO:0090501|GO:0030686|GO:0030490|GO:0006396|GO:0030688|GO:0030515|GO:0034660|GO:0032040|GO:0044822|GO:0090305|GO:0000460|GO:0000469|GO:0000462|GO:0090502|GO:0016072|GO:0000966|GO:0000480|GO:0000479|GO:0000466|GO:0000472|GO:0000447 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|preribosome|ribosome biogenesis|nuclear lumen|Noc4p-Nop14p complex|mitochondrion|ribosomal small subunit biogenesis|gene expression|RNA metabolic process|nucleus|rRNA processing|RNA phosphodiester bond hydrolysis|90S preribosome|maturation of SSU-rRNA|RNA processing|preribosome, small subunit precursor|snoRNA binding|ncRNA metabolic process|small-subunit processome|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|maturation of 5.8S rRNA|cleavage involved in rRNA processing|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA phosphodiester bond hydrolysis, endonucleolytic|rRNA metabolic process|RNA 5'-end processing|endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) - - - - 4:2937933-2963385 2118 2054 1531 941 1043 671 25.045243016357 22.0739386523497 16.3225835078073 9.96980317274357 10.119323263701 7.43619290734379 21.147255058838 9.17510644792945 1.20467361075523 1.7716556520213e-07 2.57126921902984e-06 UP ENSG00000273706 LHX1 LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6593] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0048870|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:2000744|GO:0008284|GO:0042127|GO:0001756|GO:0006935|GO:0009791|GO:0045595|GO:0035239|GO:0003712|GO:0006725|GO:0060041|GO:0001822|GO:0021692|GO:0009888|GO:0048468|GO:0035295|GO:0021697|GO:1901360|GO:0032835|GO:0007275|GO:0090009|GO:0003676|GO:0048513|GO:0060065|GO:0072028|GO:0034641|GO:0021587|GO:0030902|GO:0030900|GO:0021517|GO:0031325|GO:0046483|GO:0007420|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0007389|GO:0001763|GO:0007267|GO:0060322|GO:0007423|GO:0006928|GO:0009887|GO:0072050|GO:0003407|GO:0048729|GO:0048598|GO:0072006|GO:0048568|GO:0007548|GO:0009890|GO:0006139|GO:0021696|GO:0021695|GO:0007154|GO:0001704|GO:0022037|GO:0016477|GO:0035852|GO:0061351|GO:0061205|GO:0021694|GO:0072049|GO:0010842|GO:0060688|GO:0030030|GO:0021549|GO:0048869|GO:0048806|GO:0021537|GO:0044249|GO:0021516|GO:0090184|GO:0021680|GO:0010033|GO:0031324|GO:0040019|GO:0031323|GO:0021575|GO:0035502|GO:0071774|GO:0060560|GO:0021534|GO:0000902|GO:0031175|GO:0003677|GO:0048705|GO:0030540|GO:0010468|GO:0034645|GO:0035846|GO:0003714|GO:0046872|GO:0001654|GO:0060059|GO:0002009|GO:0032525|GO:0072164|GO:0061458|GO:0061005|GO:0007417|GO:0001655|GO:0010629|GO:0072273|GO:0048793|GO:0072210|GO:0009798|GO:0051252|GO:0009880|GO:0021510|GO:0072284|GO:0048754|GO:0007492|GO:0061138|GO:0007398|GO:0000904|GO:0009790|GO:0001656|GO:0010628|GO:0001705|GO:0030856|GO:0007369|GO:0001764|GO:0021871|GO:2000027|GO:0072001|GO:0021527|GO:0072176|GO:0003002|GO:0021533|GO:0060042|GO:0090189|GO:0044344|GO:0001706|GO:0070848|GO:0072077|GO:0030858|GO:0060066|GO:0061326|GO:0060993|GO:0060429|GO:0035849|GO:0072073|GO:0021702|GO:0010467|GO:0032990|GO:0048562|GO:0021937|GO:2000179|GO:0007399|GO:0060562|GO:0048701|GO:0072224|GO:0071310|GO:0097485|GO:0031328|GO:2000543|GO:0010470|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0001823|GO:0021940|GO:0035847|GO:2000177|GO:0016070|GO:0048703|GO:0010557|GO:0005634|GO:0072278|GO:0060067|GO:0051960|GO:0045995|GO:0048666|GO:0060068|GO:0030182|GO:0007411|GO:0021953|GO:0048706|GO:0045893|GO:2000696|GO:0000578|GO:0009792|GO:0001657|GO:0072178|GO:0030855|GO:0045892|GO:0043010|GO:0032774|GO:0043565|GO:2001141|GO:0072078|GO:0021936|GO:0071363|GO:0072163|GO:0001658|GO:0021515|GO:1902679|GO:0072177|GO:0061564|GO:0061053|GO:0061333|GO:2000768|GO:0009948|GO:0009953|GO:0072080|GO:0009952|GO:0072160|GO:0046914|GO:0001702|GO:0048704|GO:0022008|GO:0048667|GO:0003338|GO:0048812|GO:0090190|GO:0072283|GO:0006351|GO:0035282|GO:0006355|GO:0048592|GO:0006366|GO:1903507|GO:0007409|GO:0048593|GO:0008045|GO:0048699|GO:1903506|GO:0060675|GO:0072182|GO:0043009|GO:0097476|GO:0021930|GO:0008270|GO:0097477 locomotion|developmental process|growth|macromolecular complex|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|cell motility|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of anterior head development|positive regulation of cell proliferation|regulation of cell proliferation|somitogenesis|chemotaxis|post-embryonic development|regulation of cell differentiation|tube morphogenesis|transcription cofactor activity|cellular aromatic compound metabolic process|retina development in camera-type eye|kidney development|cerebellar Purkinje cell layer morphogenesis|tissue development|cell development|tube development|cerebellar cortex formation|organic cyclic compound metabolic process|glomerulus development|multicellular organism development|primitive streak formation|nucleic acid binding|animal organ development|uterus development|nephron morphogenesis|cellular nitrogen compound metabolic process|cerebellum morphogenesis|hindbrain development|forebrain development|ventral spinal cord development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|pattern specification process|morphogenesis of a branching structure|cell-cell signaling|head development|sensory organ development|movement of cell or subcellular component|organ morphogenesis|S-shaped body morphogenesis|neural retina development|tissue morphogenesis|embryonic morphogenesis|nephron development|embryonic organ development|sex differentiation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cerebellar cortex morphogenesis|cerebellar cortex development|cell communication|formation of primary germ layer|metencephalon development|cell migration|horizontal cell localization|neural precursor cell proliferation|paramesonephric duct development|cerebellar Purkinje cell layer formation|comma-shaped body morphogenesis|retina layer formation|regulation of morphogenesis of a branching structure|cell projection organization|cerebellum development|cellular developmental process|genitalia development|telencephalon development|cellular biosynthetic process|dorsal spinal cord development|positive regulation of kidney development|cerebellar Purkinje cell layer development|response to organic substance|negative regulation of cellular metabolic process|positive regulation of embryonic development|regulation of cellular metabolic process|hindbrain morphogenesis|metanephric part of ureteric bud development|response to fibroblast growth factor|developmental growth involved in morphogenesis|cell proliferation in hindbrain|cell morphogenesis|neuron projection development|DNA binding|skeletal system morphogenesis|female genitalia development|regulation of gene expression|cellular macromolecule biosynthetic process|oviduct epithelium development|transcription corepressor activity|metal ion binding|eye development|embryonic retina morphogenesis in camera-type eye|morphogenesis of an epithelium|somite rostral/caudal axis specification|mesonephric tubule development|reproductive system development|cell differentiation involved in kidney development|central nervous system development|urogenital system development|negative regulation of gene expression|metanephric nephron morphogenesis|pronephros development|metanephric nephron development|axis specification|regulation of RNA metabolic process|embryonic pattern specification|spinal cord development|metanephric S-shaped body morphogenesis|branching morphogenesis of an epithelial tube|endoderm development|morphogenesis of a branching epithelium|ectoderm development|cell morphogenesis involved in differentiation|embryo development|metanephros development|positive regulation of gene expression|ectoderm formation|regulation of epithelial cell differentiation|gastrulation|neuron migration|forebrain regionalization|regulation of organ morphogenesis|renal system development|spinal cord association neuron differentiation|nephric duct development|regionalization|cell differentiation in hindbrain|retina morphogenesis in camera-type eye|regulation of branching involved in ureteric bud morphogenesis|cellular response to fibroblast growth factor stimulus|endoderm formation|response to growth factor|renal vesicle morphogenesis|positive regulation of epithelial cell differentiation|oviduct development|renal tubule development|kidney morphogenesis|epithelium development|nephric duct elongation|kidney epithelium development|cerebellar Purkinje cell differentiation|gene expression|cell part morphogenesis|embryonic organ morphogenesis|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|positive regulation of neural precursor cell proliferation|nervous system development|epithelial tube morphogenesis|embryonic cranial skeleton morphogenesis|metanephric glomerulus development|cellular response to organic substance|neuron projection guidance|positive regulation of cellular biosynthetic process|positive regulation of gastrulation|regulation of gastrulation|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|mesonephros development|positive regulation of cerebellar granule cell precursor proliferation|uterine epithelium development|regulation of neural precursor cell proliferation|RNA metabolic process|embryonic viscerocranium morphogenesis|positive regulation of macromolecule biosynthetic process|nucleus|metanephric comma-shaped body morphogenesis|cervix development|regulation of nervous system development|regulation of embryonic development|neuron development|vagina development|neuron differentiation|axon guidance|central nervous system neuron differentiation|embryonic skeletal system development|positive regulation of transcription, DNA-templated|regulation of epithelial cell differentiation involved in kidney development|embryonic axis specification|embryo development ending in birth or egg hatching|ureteric bud development|nephric duct morphogenesis|epithelial cell differentiation|negative regulation of transcription, DNA-templated|camera-type eye development|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nephron tubule morphogenesis|regulation of cerebellar granule cell precursor proliferation|cellular response to growth factor stimulus|mesonephric epithelium development|branching involved in ureteric bud morphogenesis|cell differentiation in spinal cord|negative regulation of RNA biosynthetic process|mesonephric duct development|axon development|somite development|renal tubule morphogenesis|positive regulation of nephron tubule epithelial cell differentiation|anterior/posterior axis specification|dorsal/ventral pattern formation|nephron tubule development|anterior/posterior pattern specification|nephron tubule epithelial cell differentiation|transition metal ion binding|gastrulation with mouth forming second|embryonic skeletal system morphogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|metanephros morphogenesis|neuron projection morphogenesis|positive regulation of branching involved in ureteric bud morphogenesis|metanephric renal vesicle morphogenesis|transcription, DNA-templated|segmentation|regulation of transcription, DNA-templated|eye morphogenesis|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|axonogenesis|camera-type eye morphogenesis|motor neuron axon guidance|generation of neurons|regulation of nucleic acid-templated transcription|ureteric bud morphogenesis|regulation of nephron tubule epithelial cell differentiation|chordate embryonic development|spinal cord motor neuron migration|cerebellar granule cell precursor proliferation|zinc ion binding|lateral motor column neuron migration - - - - 17:36936785-36944612 40 49 68 143 174 159 0.389949702291124 0.434138399466962 0.597681096894851 1.24905917734608 1.3917644016686 1.45269753766742 0.473923066217646 1.36450703889403 -1.52565505194042 1.79872604759107e-07 2.60928899051428e-06 DOWN ENSG00000062650 WAPL WAPL cohesin release factor [Source:HGNC Symbol;Acc:HGNC:23293] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0016032|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0046483|GO:0051128|GO:0051098|GO:0045786|GO:0043231|GO:0048144|GO:0005737|GO:0032880|GO:0009890|GO:0006139|GO:0008104|GO:0044092|GO:0051983|GO:0007059|GO:0051301|GO:0044249|GO:0031324|GO:0031323|GO:0008278|GO:0006996|GO:0009636|GO:0051276|GO:0005829|GO:0000819|GO:0034645|GO:0051053|GO:0051100|GO:1903047|GO:0000278|GO:0048145|GO:0031981|GO:0007062|GO:0010564|GO:0048146|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0034613|GO:0033043|GO:0007067|GO:0009059|GO:1903827|GO:0005856|GO:0005634|GO:0030261|GO:0010948|GO:0008156|GO:0033365|GO:0007063|GO:0006260|GO:2001251|GO:0045875|GO:0071922|GO:0000793|GO:0033044|GO:0035562|GO:0000794|GO:0015630|GO:0006275|GO:0000795|GO:0060623|GO:0071103|GO:0000775|GO:0006323|GO:0034502|GO:0071168 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|viral process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|regulation of binding|negative regulation of cell cycle|intracellular membrane-bounded organelle|fibroblast proliferation|cytoplasm|regulation of protein localization|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|protein localization|negative regulation of molecular function|regulation of chromosome segregation|chromosome segregation|cell division|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cohesin complex|organelle organization|response to toxic substance|chromosome organization|cytosol|sister chromatid segregation|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|negative regulation of binding|mitotic cell cycle process|mitotic cell cycle|regulation of fibroblast proliferation|nuclear lumen|sister chromatid cohesion|regulation of cell cycle process|positive regulation of fibroblast proliferation|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|cellular protein localization|regulation of organelle organization|mitotic nuclear division|macromolecule biosynthetic process|regulation of cellular protein localization|cytoskeleton|nucleus|chromosome condensation|negative regulation of cell cycle process|negative regulation of DNA replication|protein localization to organelle|regulation of sister chromatid cohesion|DNA replication|negative regulation of chromosome organization|negative regulation of sister chromatid cohesion|regulation of cohesin localization to chromatin|condensed chromosome|regulation of chromosome organization|negative regulation of chromatin binding|condensed nuclear chromosome|microtubule cytoskeleton|regulation of DNA replication|synaptonemal complex|regulation of chromosome condensation|DNA conformation change|chromosome, centromeric region|DNA packaging|protein localization to chromosome|protein localization to chromatin - - - - 10:86435256-86521815 257 282 338 701 700 639 1.59216622346643 1.58775785481675 1.88793550429666 3.8910904623759 3.55812810138981 3.71009634372412 1.68928652752661 3.71977163582994 -1.13880000321379 1.81590322089244e-07 2.63292738011281e-06 DOWN ENSG00000179222 MAGED1 MAGE family member D1 [Source:HGNC Symbol;Acc:HGNC:6813] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0042752|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0071704|GO:0044237|GO:0023051|GO:0000989|GO:0009653|GO:0000785|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0042127|GO:0035239|GO:0003712|GO:0006725|GO:0001822|GO:0009888|GO:0035295|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0072028|GO:0034641|GO:0031325|GO:0046483|GO:0010942|GO:0032922|GO:0043231|GO:0005737|GO:0001763|GO:0009887|GO:0009966|GO:0048729|GO:0072006|GO:0050673|GO:0009890|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0008285|GO:0050790|GO:0060688|GO:0009967|GO:0044249|GO:0090184|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0003713|GO:0000165|GO:1902533|GO:2001235|GO:0032268|GO:0010468|GO:0034645|GO:0007166|GO:0002009|GO:0043412|GO:0072164|GO:0001655|GO:0010629|GO:0051252|GO:0048754|GO:0061138|GO:0010628|GO:0051347|GO:0036211|GO:2000027|GO:0072001|GO:0090189|GO:0051247|GO:0070848|GO:0050678|GO:0005694|GO:0050680|GO:0061326|GO:0032270|GO:0060993|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0072073|GO:0044267|GO:0051174|GO:0010467|GO:0060562|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0001823|GO:0043068|GO:1902531|GO:0016070|GO:0010557|GO:0005634|GO:0043067|GO:0097190|GO:0045893|GO:0031401|GO:0043065|GO:0001657|GO:0043408|GO:0045892|GO:0032774|GO:2001141|GO:0097192|GO:0072078|GO:0071363|GO:0072163|GO:0016310|GO:0001658|GO:0038179|GO:1902679|GO:0061333|GO:0007167|GO:0043410|GO:0072080|GO:0042981|GO:0006464|GO:0090190|GO:0097191|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0033674|GO:0048011|GO:0006366|GO:0045859|GO:1903507|GO:0045860|GO:0043406|GO:0006357|GO:0006468|GO:1903506|GO:0043405|GO:0042325|GO:0001932|GO:0060675|GO:0001934|GO:0042327|GO:0007169|GO:0071902|GO:0071900 developmental process|macromolecular complex|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|regulation of circadian rhythm|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|tube morphogenesis|transcription cofactor activity|cellular aromatic compound metabolic process|kidney development|tissue development|tube development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|nephron morphogenesis|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell death|circadian regulation of gene expression|intracellular membrane-bounded organelle|cytoplasm|morphogenesis of a branching structure|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|nephron development|epithelial cell proliferation|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|cell death|negative regulation of cell proliferation|regulation of catalytic activity|regulation of morphogenesis of a branching structure|positive regulation of signal transduction|cellular biosynthetic process|positive regulation of kidney development|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription coactivator activity|MAPK cascade|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|morphogenesis of an epithelium|macromolecule modification|mesonephric tubule development|urogenital system development|negative regulation of gene expression|regulation of RNA metabolic process|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|regulation of organ morphogenesis|renal system development|regulation of branching involved in ureteric bud morphogenesis|positive regulation of protein metabolic process|response to growth factor|regulation of epithelial cell proliferation|chromosome|negative regulation of epithelial cell proliferation|renal tubule development|positive regulation of cellular protein metabolic process|kidney morphogenesis|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|kidney epithelium development|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|epithelial tube morphogenesis|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|mesonephros development|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|apoptotic signaling pathway|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|positive regulation of apoptotic process|ureteric bud development|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|nephron tubule morphogenesis|cellular response to growth factor stimulus|mesonephric epithelium development|phosphorylation|branching involved in ureteric bud morphogenesis|neurotrophin signaling pathway|negative regulation of RNA biosynthetic process|renal tubule morphogenesis|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|nephron tubule development|regulation of apoptotic process|cellular protein modification process|positive regulation of branching involved in ureteric bud morphogenesis|extrinsic apoptotic signaling pathway|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|transcription from RNA polymerase II promoter|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|ureteric bud morphogenesis|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity K12464 melanoma-associated antigen D1[-] hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) X:51803007-51902357 440 459 602 1102 1126 1987 2.86965014180973 2.72062530692889 3.53986594843403 6.43954704028086 6.02535546798342 12.1451546654868 3.04338046572422 8.20335239125036 -1.43053890114599 1.83508022686875e-07 2.6594410239291e-06 DOWN ENSG00000219481 NBPF1 neuroblastoma breakpoint family member 1 [Source:HGNC Symbol;Acc:HGNC:26088] - - - - - - 1:16562319-16613562 131 163 170 402 390 384 0.598187815013715 0.676448303114466 0.699890378027651 1.64471429934743 1.46116418380199 1.6433348059397 0.658175498718611 1.58307109636304 -1.26618182222705 1.84739788231307e-07 2.67599303146892e-06 DOWN ENSG00000088899 RP5-1187M17.10 Leucine zipper putative tumor suppressor 3 [Source:UniProtKB/Swiss-Prot;Acc:O60299] GO:0045202|GO:0005623|GO:0016020|GO:0030054|GO:0060076|GO:0043229|GO:0071944|GO:0005622|GO:0005886|GO:0097060|GO:0045211|GO:0005737|GO:0014069|GO:0005856 synapse|cell|membrane|cell junction|excitatory synapse|intracellular organelle|cell periphery|intracellular|plasma membrane|synaptic membrane|postsynaptic membrane|cytoplasm|postsynaptic density|cytoskeleton - - - - 20:3162617-3173592 94 97 218 373 437 538 0.703702637514235 0.659953299431433 1.47140243343368 2.50187919829599 2.68416802209362 3.77460515242227 0.945019456793116 2.98688412427063 -1.66022533151691 1.8601749844167e-07 2.69319417966907e-06 DOWN ENSG00000189308 LIN54 lin-54 DREAM MuvB core complex component [Source:HGNC Symbol;Acc:HGNC:25397] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:1903047|GO:0051252|GO:0044770|GO:0000278|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000086|GO:0032774|GO:0044772|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|mitotic cell cycle process|regulation of RNA metabolic process|cell cycle phase transition|mitotic cell cycle|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|G2/M transition of mitotic cell cycle|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 4:82909973-83012926 69 121 151 346 361 300 0.296060157512103 0.471842410301181 0.584147290565671 1.33015926139878 1.27088185293689 1.20636853691493 0.450683286126318 1.26913655041687 -1.4936614487509 1.86133802847024e-07 2.69357176451529e-06 DOWN ENSG00000257225 RP11-328C8.4 - - - - - - - 12:42459366-42466128 22 21 5 0 1 0 0.557579593625414 0.483720447265614 0.114244674241024 0 0.0208037361463104 0 0.385181571710684 0.0069345787154368 5.79558663193644 1.91083121073393e-07 2.76117884633354e-06 UP ENSG00000112234 FBXL4 F-box and leucine-rich repeat protein 4 [Source:HGNC Symbol;Acc:HGNC:13601] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0043231|GO:0005737|GO:0005758|GO:0000151|GO:0019538|GO:0005740|GO:0030163|GO:0044265|GO:0031981|GO:1990234|GO:0006508|GO:0005654|GO:0005739|GO:0044267|GO:0005634|GO:0044257|GO:0051603|GO:0019941|GO:0006511 macromolecular complex|cell|cellular process|metabolic process|binding|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|intracellular membrane-bounded organelle|cytoplasm|mitochondrial intermembrane space|ubiquitin ligase complex|protein metabolic process|mitochondrial envelope|protein catabolic process|cellular macromolecule catabolic process|nuclear lumen|transferase complex|proteolysis|nucleoplasm|mitochondrion|cellular protein metabolic process|nucleus|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|ubiquitin-dependent protein catabolic process - - - - 6:98868538-98948006 82 90 150 284 340 293 0.647874143364808 0.646247870782559 1.06851790529343 2.01045292934577 2.20406048703079 2.1695734929002 0.787546639813599 2.12802896975892 -1.43408052106366 1.93412056207486e-07 2.79348017707706e-06 DOWN ENSG00000172765 TMCC1 transmembrane and coiled-coil domain family 1 [Source:HGNC Symbol;Acc:HGNC:29116] GO:0005623|GO:0016020|GO:0043229|GO:0042175|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0043231|GO:0005737|GO:0005783|GO:0016021 cell|membrane|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane - - - - 3:129647792-129893576 171 247 396 669 707 909 0.894145659535915 1.17378725888439 1.86690132371091 3.13426579939395 3.03318856377236 4.45456001187454 1.31161141404374 3.54067145834695 -1.43268261947481 1.93576542453409e-07 2.79450391605612e-06 DOWN ENSG00000167653 PSCA prostate stem cell antigen [Source:HGNC Symbol;Acc:HGNC:9500] GO:0005623|GO:0016020|GO:0005576|GO:1903561|GO:0043227|GO:0071944|GO:0031224|GO:0005886|GO:0031225|GO:0031982|GO:0070062 cell|membrane|extracellular region|extracellular vesicle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|plasma membrane|anchored component of membrane|vesicle|extracellular exosome - - - - 8:142670308-142682724 1409 1394 2122 3907 3484 6377 32.6888144735693 29.3921353876203 44.3861884795926 81.2137171886623 66.3184606880243 138.654410425307 35.4890461135941 95.3955294339979 -1.42654786043008 1.96479501142652e-07 2.83504061242761e-06 DOWN ENSG00000160799 CCDC12 coiled-coil domain containing 12 [Source:HGNC Symbol;Acc:HGNC:28332] GO:0005488|GO:0005515 binding|protein binding K12871 coiled-coil domain-containing protein 12[-] hsa03040 Spliceosome - Homo sapiens (human) 3:46921726-46982010 70 70 99 248 250 193 0.587651102446979 0.534074429804755 0.749330676096641 1.86540926902429 1.72199499055344 1.51848691468773 0.623685402782792 1.70196372475515 -1.44830988962619 1.97368925407348e-07 2.84649850198598e-06 DOWN ENSG00000163681 SLMAP sarcolemma associated protein [Source:HGNC Symbol;Acc:HGNC:16643] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0006457|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0005887|GO:0043231|GO:0005737|GO:0003012|GO:0042383|GO:0031226|GO:0005783|GO:0016272|GO:0051082|GO:0016021|GO:0006936|GO:0005815|GO:0005790|GO:0005856|GO:0015630 macromolecular complex|cell|membrane|cellular process|binding|intracellular organelle|protein folding|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|muscle system process|sarcolemma|intrinsic component of plasma membrane|endoplasmic reticulum|prefoldin complex|unfolded protein binding|integral component of membrane|muscle contraction|microtubule organizing center|smooth endoplasmic reticulum|cytoskeleton|microtubule cytoskeleton - - - - 3:57755450-57929168 460 648 757 1324 1546 1420 1.19558211926736 1.53065228529368 1.77391058630835 3.08323881724424 3.29684681458225 3.45890671849012 1.5000483302898 3.2796641167722 -1.12853908648252 2.00635491675758e-07 2.89221244253408e-06 DOWN ENSG00000113460 BRIX1 BRX1, biogenesis of ribosomes [Source:HGNC Symbol;Acc:HGNC:24170] GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0003676|GO:0022607|GO:0043231|GO:0022613|GO:0006996|GO:0005730|GO:0003723|GO:0042254|GO:0022618|GO:0031981|GO:0070925|GO:0042273|GO:0005634|GO:0034622|GO:0042255|GO:0000027|GO:0044822 cell|cellular process|binding|organic cyclic compound binding|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|nucleic acid binding|cellular component assembly|intracellular membrane-bounded organelle|ribonucleoprotein complex biogenesis|organelle organization|nucleolus|RNA binding|ribosome biogenesis|ribonucleoprotein complex assembly|nuclear lumen|organelle assembly|ribosomal large subunit biogenesis|nucleus|cellular macromolecular complex assembly|ribosome assembly|ribosomal large subunit assembly|poly(A) RNA binding - - - - 5:34915376-34925996 2562 2875 2020 1223 1398 826 24.5433103214665 25.0306346763177 17.4469566110068 10.4973166238585 10.9882644893713 7.41589061803014 22.3403005362637 9.63382391041998 1.21346813470728 2.00905970716761e-07 2.89471373058793e-06 UP ENSG00000245275 SAP30L-AS1 SAP30L antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:26760] - - - - - - 5:154329437-154445850 16 20 27 73 78 73 0.484919994909828 0.55087662449931 0.737778076150127 1.98228018199178 1.93956967682766 2.07347646243661 0.591191565186422 1.99844210708535 -1.75717818877688 2.0199027008798e-07 2.90893271741754e-06 DOWN ENSG00000181007 ZFP82 ZFP82 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:28682] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:36383120-36418656 154 173 144 54 69 68 1.12292534600645 1.14645229196339 0.946683073302937 0.352792269286154 0.412804768874582 0.464693827408313 1.07202023709093 0.410096955189683 1.38629520319905 2.03495155645246e-07 2.92919208130819e-06 UP ENSG00000139323 POC1B POC1 centriolar protein B [Source:HGNC Symbol;Acc:HGNC:30836] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0008283|GO:0043229|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0022607|GO:0005737|GO:0042592|GO:0048871|GO:0036064|GO:0030030|GO:0048869|GO:0006996|GO:0000902|GO:0005813|GO:0001894|GO:0005815|GO:0005814|GO:0044782|GO:0030031|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0005856|GO:0000922|GO:0005819|GO:0060271|GO:0001895|GO:0015630 developmental process|cell|cellular process|binding|cell projection|cell proliferation|intracellular organelle|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|cellular component assembly|cytoplasm|homeostatic process|multicellular organismal homeostasis|ciliary basal body|cell projection organization|cellular developmental process|organelle organization|cell morphogenesis|centrosome|tissue homeostasis|microtubule organizing center|centriole|cilium organization|cell projection assembly|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|cytoskeleton|spindle pole|spindle|cilium morphogenesis|retina homeostasis|microtubule cytoskeleton - - - - 12:89419718-89526024 154 144 230 442 485 438 0.891229549342109 0.757373108024708 1.20007784251998 2.29185757007611 2.30291401591131 2.37558891814296 0.949560166628932 2.32345350137679 -1.29093945155152 2.0759927174757e-07 2.98538952733717e-06 DOWN ENSG00000143369 ECM1 extracellular matrix protein 1 [Source:HGNC Symbol;Acc:HGNC:3153] GO:0040011|GO:0032502|GO:0031012|GO:0004871|GO:0002376|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0009892|GO:0050840|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0005578|GO:0006807|GO:0006950|GO:0071704|GO:0050900|GO:0006955|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0043227|GO:0023057|GO:0009058|GO:0005615|GO:0050793|GO:0002682|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0008284|GO:0042127|GO:0006725|GO:0009888|GO:0002685|GO:0008022|GO:1901360|GO:0001568|GO:0007275|GO:0048513|GO:0030279|GO:0005102|GO:0034641|GO:0006952|GO:0031982|GO:0046483|GO:0042092|GO:0060761|GO:0019899|GO:0006928|GO:0009966|GO:0050673|GO:0010646|GO:0006139|GO:0050776|GO:0001525|GO:0007154|GO:0044092|GO:0051270|GO:0016477|GO:0007165|GO:0030278|GO:0043236|GO:0009968|GO:0070062|GO:0001503|GO:0070168|GO:0050790|GO:0072676|GO:0043086|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0050679|GO:1902533|GO:0032268|GO:0010468|GO:0005126|GO:0034645|GO:0007166|GO:0070851|GO:0001959|GO:0001944|GO:0072358|GO:0034097|GO:0051252|GO:0072678|GO:0031214|GO:0030334|GO:0001935|GO:0032269|GO:0006954|GO:0002828|GO:0030502|GO:0045766|GO:0002020|GO:0045765|GO:0051346|GO:0006508|GO:0050678|GO:1901342|GO:0035556|GO:0044267|GO:0010467|GO:0071310|GO:2000401|GO:0051246|GO:0001960|GO:0009059|GO:1902531|GO:0016070|GO:0072359|GO:0030282|GO:0030500|GO:0010466|GO:0019221|GO:0043122|GO:0005134|GO:0032774|GO:0030162|GO:2001141|GO:2000404|GO:0052547|GO:0001936|GO:0043123|GO:0007249|GO:0071345|GO:0045861|GO:0001938|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 locomotion|developmental process|extracellular matrix|signal transducer activity|immune system process|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|extracellular matrix binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|nitrogen compound metabolic process|response to stress|organic substance metabolic process|leukocyte migration|immune response|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|extracellular space|regulation of developmental process|regulation of immune system process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|tissue development|regulation of leukocyte migration|protein C-terminus binding|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|animal organ development|negative regulation of ossification|receptor binding|cellular nitrogen compound metabolic process|defense response|vesicle|heterocycle metabolic process|type 2 immune response|negative regulation of response to cytokine stimulus|enzyme binding|movement of cell or subcellular component|regulation of signal transduction|epithelial cell proliferation|regulation of cell communication|nucleobase-containing compound metabolic process|regulation of immune response|angiogenesis|cell communication|negative regulation of molecular function|regulation of cellular component movement|cell migration|signal transduction|regulation of ossification|laminin binding|negative regulation of signal transduction|extracellular exosome|ossification|negative regulation of biomineral tissue development|regulation of catalytic activity|lymphocyte migration|negative regulation of catalytic activity|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|growth factor receptor binding|regulation of cytokine-mediated signaling pathway|vasculature development|cardiovascular system development|response to cytokine|regulation of RNA metabolic process|T cell migration|biomineral tissue development|regulation of cell migration|endothelial cell proliferation|negative regulation of cellular protein metabolic process|inflammatory response|regulation of type 2 immune response|negative regulation of bone mineralization|positive regulation of angiogenesis|protease binding|regulation of angiogenesis|negative regulation of hydrolase activity|proteolysis|regulation of epithelial cell proliferation|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|gene expression|cellular response to organic substance|regulation of lymphocyte migration|regulation of protein metabolic process|negative regulation of cytokine-mediated signaling pathway|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|bone mineralization|regulation of bone mineralization|negative regulation of peptidase activity|cytokine-mediated signaling pathway|regulation of I-kappaB kinase/NF-kappaB signaling|interleukin-2 receptor binding|RNA biosynthetic process|regulation of proteolysis|regulation of RNA biosynthetic process|regulation of T cell migration|regulation of peptidase activity|regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|cellular response to cytokine stimulus|negative regulation of proteolysis|positive regulation of endothelial cell proliferation|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 1:150508062-150513789 150 158 153 71 64 55 1.39318517185754 1.33369140342607 1.28122483406763 0.590845619689489 0.487712600791547 0.478747255288459 1.33603380311708 0.519101825256498 1.3638670444072 2.08821469108749e-07 3.00151956609176e-06 UP ENSG00000237846 RP11-216M21.1 - - - - - - - 9:40105822-40106527 6 7 7 41 35 30 0.601135095876757 0.637452605115235 0.632313016714059 3.68062150079625 2.87725374676818 2.81707426109511 0.623633572568684 3.12498316955318 -2.32507791876541 2.12422956416361e-07 3.0503486968995e-06 DOWN ENSG00000166444 ST5 suppression of tumorigenicity 5 [Source:HGNC Symbol;Acc:HGNC:11350] GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0023051|GO:0009893|GO:0005085|GO:0019222|GO:0031325|GO:0005088|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0043412|GO:0051345|GO:0017112|GO:0036211|GO:0051247|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:1902531|GO:0031401|GO:0043408|GO:0043087|GO:0016310|GO:0070371|GO:0043547|GO:0043410|GO:0006464|GO:0006468|GO:0042325|GO:0070374|GO:0001932|GO:0001934|GO:0070372|GO:0042327 signaling|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|regulation of signaling|positive regulation of metabolic process|guanyl-nucleotide exchange factor activity|regulation of metabolic process|positive regulation of cellular metabolic process|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|macromolecule modification|positive regulation of hydrolase activity|Rab guanyl-nucleotide exchange factor activity|protein modification process|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of intracellular signal transduction|positive regulation of protein modification process|regulation of MAPK cascade|regulation of GTPase activity|phosphorylation|ERK1 and ERK2 cascade|positive regulation of GTPase activity|positive regulation of MAPK cascade|cellular protein modification process|protein phosphorylation|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation - - - - 11:8693351-8910951 166 170 164 421 426 436 0.38386078904827 0.357268432606793 0.341920023996275 0.872259209983745 0.808245852328553 0.944889877049872 0.361016415217113 0.875131646454057 -1.27743562139445 2.1422428207654e-07 3.07473640245819e-06 DOWN ENSG00000001167 NFYA nuclear transcription factor Y subunit alpha [Source:HGNC Symbol;Acc:HGNC:7804] GO:0032991|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0044281|GO:0031325|GO:0046483|GO:0043231|GO:0005667|GO:0006139|GO:0008134|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0044798|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0001221|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0090575|GO:0006351|GO:0006355|GO:0006366|GO:1903506|GO:0044212|GO:0016602|GO:0001047|GO:0000976|GO:0001046 macromolecular complex|cell|rhythmic process|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor complex|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|nuclear transcription factor complex|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|transcription cofactor binding|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|RNA polymerase II transcription factor complex|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|CCAAT-binding factor complex|core promoter binding|transcription regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding K08064 nuclear transcription factor Y, alpha[-] hsa05152|hsa04612 Tuberculosis - Homo sapiens (human)|Antigen processing and presentation - Homo sapiens (human) 6:41072945-41099976 1898 2235 1601 1040 999 836 29.7888908375446 31.8798165341303 22.6549866178757 14.6247709282641 12.8644584103346 12.2968414231334 28.1078979965169 13.262023587244 1.08367464212846 2.14718630344742e-07 3.08035078823255e-06 UP ENSG00000219529 AP000580.1 - - - - - - - 11:77813319-77813676 54 59 37 11 16 13 10.6698636370045 10.5949196852597 6.59149315559087 1.94736681443899 2.59386813381873 2.40741822181882 9.28542549261836 2.31621772335885 2.00319714896492 2.15330661194043e-07 3.08616493484731e-06 UP ENSG00000243317 C7orf73 chromosome 7 open reading frame 73 [Source:HGNC Symbol;Acc:HGNC:41909] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0043231|GO:0005737|GO:0031966|GO:0016021|GO:0005740|GO:0005739 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|integral component of membrane|mitochondrial envelope|mitochondrion - - - - 7:135662496-135693418 414 430 488 969 1150 884 5.35082889465872 5.0509045757931 5.68662313066898 11.221261160996 12.1951184967905 10.707826175031 5.36278553370693 11.3747352776058 -1.08477850612462 2.15310319283827e-07 3.08616493484731e-06 DOWN ENSG00000253958 CLDN23 claudin 23 [Source:HGNC Symbol;Acc:HGNC:17591] GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0005911|GO:0016043|GO:0007155|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0042802|GO:0022607|GO:0098609|GO:0016021|GO:0043296|GO:0098742|GO:0045216|GO:0034329|GO:0005923|GO:0007043|GO:0016338|GO:0070830|GO:0043297 structural molecule activity|cell|membrane|cellular process|cell junction|binding|cell-cell junction|cellular component organization|cell adhesion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|identical protein binding|cellular component assembly|cell-cell adhesion|integral component of membrane|apical junction complex|cell-cell adhesion via plasma-membrane adhesion molecules|cell-cell junction organization|cell junction assembly|bicellular tight junction|cell-cell junction assembly|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|bicellular tight junction assembly|apical junction assembly K06087 claudin[-] hsa04514|hsa04530|hsa05160|hsa04670 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human) 8:8701938-8704106 241 295 264 130 127 89 7.85963608640853 8.74356133609192 7.7625350339586 3.79864193916106 3.39826336054469 2.72024297965483 8.12191081881968 3.30571609312019 1.29685636002456 2.15842597839497e-07 3.09201771396369e-06 UP ENSG00000159882 ZNF230 zinc finger protein 230 [Source:HGNC Symbol;Acc:HGNC:13024] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:44002948-44013926 248 273 202 78 107 107 1.64473267790472 1.6454588310748 1.20784106146329 0.463483419154038 0.582232492919068 0.665056391634264 1.4993441901476 0.570257434569123 1.39464635154884 2.16351429856035e-07 3.09633537244587e-06 UP ENSG00000108984 MAP2K6 mitogen-activated protein kinase kinase 6 [Source:HGNC Symbol;Acc:HGNC:6846] GO:0032502|GO:0004871|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0005057|GO:0044702|GO:0071704|GO:0043167|GO:0006955|GO:0042698|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0032504|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0022602|GO:0005515|GO:0016740|GO:0048856|GO:0048609|GO:0019222|GO:0002757|GO:0051726|GO:0007049|GO:0045087|GO:0004708|GO:0045595|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0010941|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0043270|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0061061|GO:0045786|GO:0045597|GO:0043231|GO:0019899|GO:0005737|GO:0003012|GO:0002218|GO:0002931|GO:0009966|GO:0042493|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0006975|GO:0008219|GO:0051047|GO:0050790|GO:0000166|GO:0048869|GO:0009967|GO:0044249|GO:0010876|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0003013|GO:0032370|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0009743|GO:0051149|GO:0010468|GO:0006936|GO:0034645|GO:0035639|GO:0043412|GO:0002758|GO:2000193|GO:0042692|GO:0051252|GO:0001883|GO:0007050|GO:0051147|GO:0051347|GO:0036211|GO:0000278|GO:0006811|GO:0032549|GO:0051046|GO:0031981|GO:0031098|GO:0032368|GO:0007346|GO:0006869|GO:0051247|GO:0005654|GO:0002764|GO:0016301|GO:0043269|GO:0019900|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0046903|GO:0071310|GO:0017076|GO:0032305|GO:0051246|GO:0009059|GO:0030154|GO:0043068|GO:1902531|GO:0016070|GO:0016773|GO:0008015|GO:0005856|GO:0010557|GO:0005634|GO:0043067|GO:0045089|GO:0006974|GO:0030522|GO:0045088|GO:0006941|GO:0071322|GO:0006820|GO:0015711|GO:0031401|GO:0043065|GO:0043408|GO:0032308|GO:0032774|GO:0005524|GO:0060047|GO:2001141|GO:0030554|GO:0016310|GO:0015908|GO:0035872|GO:0002221|GO:0046942|GO:0043410|GO:0051770|GO:0042981|GO:0044070|GO:0004672|GO:2000191|GO:0019901|GO:0006464|GO:0051403|GO:0046717|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0033674|GO:0015732|GO:0015718|GO:0045859|GO:0045860|GO:0002224|GO:0043406|GO:0006468|GO:0004712|GO:1903506|GO:0043405|GO:0060048|GO:0042325|GO:0004713|GO:0001932|GO:0070423|GO:0018193|GO:0004674|GO:0001934|GO:0072709|GO:0042327|GO:0034166|GO:0034134|GO:0038124|GO:0000187|GO:0002756|GO:0071902|GO:0034138|GO:0002755|GO:0034146|GO:0071900|GO:0034142|GO:0038123|GO:0034162|GO:0032147|GO:0018108|GO:0035666 developmental process|signal transducer activity|reproduction|immune system process|signaling|cell|rhythmic process|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|receptor signaling protein activity|single organism reproductive process|organic substance metabolic process|ion binding|immune response|ovulation cycle|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|ovulation cycle process|protein binding|transferase activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|immune response-activating signal transduction|regulation of cell cycle|cell cycle|innate immune response|MAP kinase kinase activity|regulation of cell differentiation|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|muscle structure development|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|muscle system process|activation of innate immune response|response to ischemia|regulation of signal transduction|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|DNA damage induced protein phosphorylation|cell death|positive regulation of secretion|regulation of catalytic activity|nucleotide binding|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|circulatory system process|positive regulation of lipid transport|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|response to carbohydrate|positive regulation of muscle cell differentiation|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|positive regulation of fatty acid transport|muscle cell differentiation|regulation of RNA metabolic process|purine nucleoside binding|cell cycle arrest|regulation of muscle cell differentiation|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ion transport|ribonucleoside binding|regulation of secretion|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of lipid transport|regulation of mitotic cell cycle|lipid transport|positive regulation of protein metabolic process|nucleoplasm|immune response-regulating signaling pathway|kinase activity|regulation of ion transport|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|secretion|cellular response to organic substance|purine nucleotide binding|positive regulation of icosanoid secretion|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|blood circulation|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|positive regulation of innate immune response|cellular response to DNA damage stimulus|intracellular receptor signaling pathway|regulation of innate immune response|striated muscle contraction|cellular response to carbohydrate stimulus|anion transport|organic anion transport|positive regulation of protein modification process|positive regulation of apoptotic process|regulation of MAPK cascade|positive regulation of prostaglandin secretion|RNA biosynthetic process|ATP binding|heart contraction|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|fatty acid transport|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|pattern recognition receptor signaling pathway|carboxylic acid transport|positive regulation of MAPK cascade|positive regulation of nitric-oxide synthase biosynthetic process|regulation of apoptotic process|regulation of anion transport|protein kinase activity|regulation of fatty acid transport|protein kinase binding|cellular protein modification process|stress-activated MAPK cascade|acid secretion|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|prostaglandin transport|monocarboxylic acid transport|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|protein phosphorylation|protein serine/threonine/tyrosine kinase activity|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|cardiac muscle contraction|regulation of phosphorylation|protein tyrosine kinase activity|regulation of protein phosphorylation|nucleotide-binding oligomerization domain containing signaling pathway|peptidyl-amino acid modification|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|cellular response to sorbitol|positive regulation of phosphorylation|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|activation of MAPK activity|MyD88-independent toll-like receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|regulation of protein serine/threonine kinase activity|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|activation of protein kinase activity|peptidyl-tyrosine phosphorylation|TRIF-dependent toll-like receptor signaling pathway K04433 mitogen-activated protein kinase kinase 6[2.7.12.2] hsa04010|hsa04015|hsa05169|hsa05164|hsa04380|hsa05145|hsa04668|hsa04620|hsa04750|hsa04912|hsa04664|hsa05014 MAPK signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) 17:69414698-69543331 22 25 30 94 75 105 0.153426466115403 0.158455385648684 0.1886300711375 0.58736150945542 0.429151354200983 0.6862712674421 0.166837307633862 0.567594710366168 -1.76641920864518 2.19768997928591e-07 3.14279799621865e-06 DOWN ENSG00000173542 MOB1B MOB kinase activator 1B [Source:HGNC Symbol;Acc:HGNC:29801] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0008047|GO:0031982|GO:0031325|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0007154|GO:0007165|GO:0070062|GO:0019207|GO:0019538|GO:0031323|GO:0005829|GO:0046872|GO:0043412|GO:0036211|GO:0019900|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0019209|GO:0005634|GO:0016310|GO:0035329|GO:0006464|GO:0006468|GO:0042325|GO:0042327|GO:0046777 signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|enzyme activator activity|vesicle|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|cell communication|signal transduction|extracellular exosome|kinase regulator activity|protein metabolic process|regulation of cellular metabolic process|cytosol|metal ion binding|macromolecule modification|protein modification process|kinase binding|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|kinase activator activity|nucleus|phosphorylation|hippo signaling|cellular protein modification process|protein phosphorylation|regulation of phosphorylation|positive regulation of phosphorylation|protein autophosphorylation K06685 MOB kinase activator 1[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) 4:70902326-71022449 133 202 217 573 390 646 0.935281297174052 1.29098668058177 1.37582962196454 3.61029707113842 2.25021317936939 4.25747597047782 1.20069919990679 3.37266207366188 -1.4900130024851 2.19808475115715e-07 3.14279799621865e-06 DOWN ENSG00000186480 INSIG1 insulin induced gene 1 [Source:HGNC Symbol;Acc:HGNC:6083] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0060341|GO:0044255|GO:0045595|GO:0006725|GO:0097094|GO:0035459|GO:0032937|GO:0006810|GO:1901360|GO:0048839|GO:0006082|GO:0007275|GO:0060627|GO:0045596|GO:0048513|GO:0034641|GO:0044281|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0051668|GO:0043231|GO:0031227|GO:0005737|GO:0007423|GO:0009887|GO:0048598|GO:0048568|GO:0009890|GO:0032387|GO:0006139|GO:0030176|GO:0007154|GO:0061024|GO:0006629|GO:0007165|GO:0005783|GO:0042180|GO:0051649|GO:0060348|GO:0045833|GO:0048869|GO:0016021|GO:0044249|GO:0043254|GO:0031301|GO:0031324|GO:0031323|GO:0006991|GO:0060021|GO:0006996|GO:0016192|GO:0048705|GO:0031333|GO:0010468|GO:0034645|GO:0046486|GO:0006900|GO:0016050|GO:0090114|GO:0043583|GO:0006984|GO:0051252|GO:0006066|GO:0006631|GO:0032386|GO:1901301|GO:0009790|GO:0010628|GO:0051055|GO:0042474|GO:0045599|GO:0046907|GO:0042472|GO:0006638|GO:0045939|GO:0090110|GO:0006461|GO:0010565|GO:0008202|GO:0033043|GO:0010467|GO:0048562|GO:0008610|GO:0019216|GO:0060349|GO:0060628|GO:0045598|GO:0046890|GO:0031328|GO:0045922|GO:0009059|GO:0030154|GO:0001501|GO:0016070|GO:0010557|GO:0060363|GO:0019217|GO:0045893|GO:0045444|GO:0034622|GO:0032774|GO:0019218|GO:2001141|GO:0043623|GO:0048193|GO:0016482|GO:0006694|GO:0042471|GO:0006633|GO:0032933|GO:0050810|GO:0016125|GO:1901303|GO:0010894|GO:0045717|GO:0019752|GO:0006639|GO:0042304|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0016126|GO:0008203|GO:0032787|GO:0006888|GO:0006641|GO:0006695 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cellular localization|cellular lipid metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|craniofacial suture morphogenesis|cargo loading into vesicle|SREBP-SCAP-Insig complex|transport|organic cyclic compound metabolic process|inner ear development|organic acid metabolic process|multicellular organism development|regulation of vesicle-mediated transport|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|localization within membrane|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cytoplasm|sensory organ development|organ morphogenesis|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|negative regulation of intracellular transport|nucleobase-containing compound metabolic process|integral component of endoplasmic reticulum membrane|cell communication|membrane organization|lipid metabolic process|signal transduction|endoplasmic reticulum|cellular ketone metabolic process|establishment of localization in cell|bone development|negative regulation of lipid metabolic process|cellular developmental process|integral component of membrane|cellular biosynthetic process|regulation of protein complex assembly|integral component of organelle membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to sterol depletion|palate development|organelle organization|vesicle-mediated transport|skeletal system morphogenesis|negative regulation of protein complex assembly|regulation of gene expression|cellular macromolecule biosynthetic process|glycerolipid metabolic process|membrane budding|vesicle organization|COPII-coated vesicle budding|ear development|ER-nucleus signaling pathway|regulation of RNA metabolic process|alcohol metabolic process|fatty acid metabolic process|regulation of intracellular transport|regulation of cargo loading into COPII-coated vesicle|embryo development|positive regulation of gene expression|negative regulation of lipid biosynthetic process|middle ear morphogenesis|negative regulation of fat cell differentiation|intracellular transport|inner ear morphogenesis|neutral lipid metabolic process|negative regulation of steroid metabolic process|cargo loading into COPII-coated vesicle|protein complex assembly|regulation of cellular ketone metabolic process|steroid metabolic process|regulation of organelle organization|gene expression|embryonic organ morphogenesis|lipid biosynthetic process|regulation of lipid metabolic process|bone morphogenesis|regulation of ER to Golgi vesicle-mediated transport|regulation of fat cell differentiation|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|negative regulation of fatty acid metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|cranial suture morphogenesis|regulation of fatty acid metabolic process|positive regulation of transcription, DNA-templated|fat cell differentiation|cellular macromolecular complex assembly|RNA biosynthetic process|regulation of steroid metabolic process|regulation of RNA biosynthetic process|cellular protein complex assembly|Golgi vesicle transport|cytosolic transport|steroid biosynthetic process|ear morphogenesis|fatty acid biosynthetic process|SREBP signaling pathway|regulation of steroid biosynthetic process|sterol metabolic process|negative regulation of cargo loading into COPII-coated vesicle|negative regulation of steroid biosynthetic process|negative regulation of fatty acid biosynthetic process|carboxylic acid metabolic process|acylglycerol metabolic process|regulation of fatty acid biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|sterol biosynthetic process|cholesterol metabolic process|monocarboxylic acid metabolic process|ER to Golgi vesicle-mediated transport|triglyceride metabolic process|cholesterol biosynthetic process - - - - 7:155297776-155310235 1355 1441 2757 605 664 999 11.8697771404104 11.4722097300202 21.7748008783539 4.74849552988088 4.77242853377277 8.20158273794276 15.0389292495948 5.9075022671988 1.34808166984032 2.23497885853333e-07 3.1924908537155e-06 UP ENSG00000149792 MRPL49 mitochondrial ribosomal protein L49 [Source:HGNC Symbol;Acc:HGNC:1176] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0031090|GO:0019866|GO:0034641|GO:0005761|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0031966|GO:0044249|GO:0019538|GO:0006996|GO:0005740|GO:0034645|GO:0006518|GO:0007005|GO:0005840|GO:0005743|GO:0005759|GO:0005739|GO:0015934|GO:0070124|GO:0043603|GO:0044267|GO:0010467|GO:0005762|GO:0009059|GO:0032543|GO:0043241|GO:0043043|GO:0070125|GO:0006412|GO:0070126|GO:0006414|GO:0043624|GO:0006415 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|organelle membrane|organelle inner membrane|cellular nitrogen compound metabolic process|mitochondrial ribosome|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|cellular biosynthetic process|protein metabolic process|organelle organization|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|mitochondrion organization|ribosome|mitochondrial inner membrane|mitochondrial matrix|mitochondrion|large ribosomal subunit|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|mitochondrial large ribosomal subunit|macromolecule biosynthetic process|mitochondrial translation|protein complex disassembly|peptide biosynthetic process|mitochondrial translational elongation|translation|mitochondrial translational termination|translational elongation|cellular protein complex disassembly|translational termination - - - - 11:65122183-65127371 3875 3937 3313 1927 1983 1019 26.7811735863998 24.7288170939456 20.6439843210482 11.9326592426667 11.2447177866569 6.60025760136228 24.0513250004645 9.92587821022863 1.27684971693473 2.25597188143906e-07 3.22093661159645e-06 UP ENSG00000103343 ZNF174 zinc finger protein 174 [Source:HGNC Symbol;Acc:HGNC:12963] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0000981|GO:0046983|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0042803|GO:0015629|GO:0000975|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|protein dimerization activity|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|protein homodimerization activity|actin cytoskeleton|regulatory region DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter - - - - 16:3401235-3409370 66 64 89 208 222 189 0.766100088189299 0.675153812448383 0.931421030000518 2.16323736703927 2.1142856702049 2.05604812026543 0.790891643546067 2.11119038583653 -1.41650472960619 2.26905488805624e-07 3.23671669872046e-06 DOWN ENSG00000112992 NNT nicotinamide nucleotide transhydrogenase [Source:HGNC Symbol;Acc:HGNC:7863] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0070469|GO:0043227|GO:0048037|GO:0031224|GO:0005622|GO:0031090|GO:0006725|GO:0019866|GO:0006810|GO:1901360|GO:0005746|GO:0006082|GO:0034641|GO:0015980|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0042592|GO:0072593|GO:0031966|GO:0019725|GO:0051186|GO:0022891|GO:0006139|GO:0016651|GO:0055086|GO:0006099|GO:0055085|GO:0050662|GO:0000166|GO:0006091|GO:0016021|GO:0045454|GO:0055114|GO:0005740|GO:0050661|GO:0006811|GO:0006740|GO:0015075|GO:0005743|GO:0005739|GO:0006796|GO:0045333|GO:0051287|GO:0034220|GO:0098655|GO:0009060|GO:0009117|GO:0015992|GO:0006812|GO:0019752|GO:0008746|GO:0008324|GO:0072350|GO:1902600|GO:0008750|GO:0003957|GO:0022890|GO:0015672|GO:0006739|GO:0015077|GO:0006101|GO:0015078 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|respiratory chain|membrane-bounded organelle|cofactor binding|intrinsic component of membrane|intracellular|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|transport|organic cyclic compound metabolic process|mitochondrial respiratory chain|organic acid metabolic process|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|reactive oxygen species metabolic process|mitochondrial membrane|cellular homeostasis|cofactor metabolic process|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|oxidoreductase activity, acting on NAD(P)H|nucleobase-containing small molecule metabolic process|tricarboxylic acid cycle|transmembrane transport|coenzyme binding|nucleotide binding|generation of precursor metabolites and energy|integral component of membrane|cell redox homeostasis|oxidation-reduction process|mitochondrial envelope|NADP binding|ion transport|NADPH regeneration|ion transmembrane transporter activity|mitochondrial inner membrane|mitochondrion|phosphate-containing compound metabolic process|cellular respiration|NAD binding|ion transmembrane transport|cation transmembrane transport|aerobic respiration|nucleotide metabolic process|proton transport|cation transport|carboxylic acid metabolic process|NAD(P)+ transhydrogenase activity|cation transmembrane transporter activity|tricarboxylic acid metabolic process|hydrogen ion transmembrane transport|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|inorganic cation transmembrane transporter activity|monovalent inorganic cation transport|NADP metabolic process|monovalent inorganic cation transmembrane transporter activity|citrate metabolic process|hydrogen ion transmembrane transporter activity K00323 NAD(P) transhydrogenase[1.6.1.2] hsa01100|hsa00760 Metabolic pathways - Homo sapiens (human)|Nicotinate and nicotinamide metabolism - Homo sapiens (human) 5:43602692-43707405 161 192 258 454 531 544 0.936793665523674 1.01531315284867 1.35348662704859 2.36686232708088 2.53502213197215 2.96651793678575 1.10186448180698 2.62280079861293 -1.25116144134567 2.26919275488106e-07 3.23671669872046e-06 DOWN ENSG00000106404 CLDN15 claudin 15 [Source:HGNC Symbol;Acc:HGNC:2036] GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0005911|GO:0016043|GO:0007155|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0042802|GO:0006810|GO:0022607|GO:0098609|GO:0016328|GO:0016021|GO:0043296|GO:0098742|GO:0045216|GO:0006811|GO:0034329|GO:0005923|GO:0007043|GO:0016338|GO:0070830|GO:0043297 structural molecule activity|cell|membrane|cellular process|cell junction|binding|cell-cell junction|cellular component organization|cell adhesion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|identical protein binding|transport|cellular component assembly|cell-cell adhesion|lateral plasma membrane|integral component of membrane|apical junction complex|cell-cell adhesion via plasma-membrane adhesion molecules|cell-cell junction organization|ion transport|cell junction assembly|bicellular tight junction|cell-cell junction assembly|calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules|bicellular tight junction assembly|apical junction assembly K06087 claudin[-] hsa04514|hsa04530|hsa05160|hsa04670 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human) 7:101232092-101238820 251 254 196 70 116 90 2.84762671400973 2.61892136777605 2.00483792294902 0.711552757987865 1.07978000518656 0.956935488091267 2.49046200157827 0.916089417088564 1.44285307115235 2.28707662447986e-07 3.26066788668681e-06 UP ENSG00000002586 CD99 CD99 molecule [Source:HGNC Symbol;Acc:HGNC:7082] GO:0005623|GO:0016020|GO:0030054|GO:0030055|GO:0007155|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0005924|GO:0005912|GO:0005887|GO:0005737|GO:0031226|GO:0016021|GO:0005925 cell|membrane|cell junction|cell-substrate junction|cell adhesion|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|cell-substrate adherens junction|adherens junction|integral component of plasma membrane|cytoplasm|intrinsic component of plasma membrane|integral component of membrane|focal adhesion K06520 CD99 antigen[-] hsa04514|hsa04670 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human) X:2691179-2741309 826 785 1108 1940 2104 2082 9.02094174681012 7.79151202810609 10.9100323308334 18.9832771921378 18.8532213639023 21.3099072096662 9.24082870191654 19.7154685885688 -1.09323385918208 2.30626162009727e-07 3.28645032966033e-06 DOWN ENSG00000237523 LINC00857 long intergenic non-protein coding RNA 857 [Source:HGNC Symbol;Acc:HGNC:45114] - - - - - - 10:80207710-80219657 106 102 125 271 412 270 2.68748708862007 2.35028846310577 2.85735587109359 6.15612972524652 8.57050328481831 6.41555834695224 2.63171047427314 7.04739711900569 -1.42108973110415 2.35043038097324e-07 3.34619688095255e-06 DOWN ENSG00000260948 RP11-552M11.8 - - - - - - - 1:111431046-111433068 25 38 57 0 3 12 0.874166319885058 1.20757166535079 1.79695938768268 0 0.08607590776279 0.393227613090963 1.29289912430618 0.159767840284584 3.01656077424457 2.34960123464273e-07 3.34619688095255e-06 UP ENSG00000273154 RP4-583P15.15 - GO:0002376|GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0006955|GO:0031224|GO:0002684|GO:0002682|GO:0002757|GO:0003676|GO:0043169|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0016021|GO:0046872|GO:0007166|GO:0002429|GO:0002764|GO:0002768|GO:0050851|GO:0050852|GO:0050853 immune system process|signaling|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|immune response|intrinsic component of membrane|positive regulation of immune system process|regulation of immune system process|immune response-activating signal transduction|nucleic acid binding|cation binding|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|integral component of membrane|metal ion binding|cell surface receptor signaling pathway|immune response-activating cell surface receptor signaling pathway|immune response-regulating signaling pathway|immune response-regulating cell surface receptor signaling pathway|antigen receptor-mediated signaling pathway|T cell receptor signaling pathway|B cell receptor signaling pathway - - - - 20:63708864-63739103 98 226 108 35 38 48 1.68503171455145 3.53158246715355 1.67424146100725 0.539191459387736 0.536089622416738 0.773490247601575 2.29695188090408 0.616257109802016 1.89811634268208 2.3569778011645e-07 3.35391874527955e-06 UP ENSG00000005206 SPPL2B signal peptide peptidase like 2B [Source:HGNC Symbol;Acc:HGNC:30627] GO:0002376|GO:0005623|GO:0016020|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0006955|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0002682|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0042802|GO:0098554|GO:0030660|GO:0031982|GO:0043231|GO:0031227|GO:0008233|GO:0005774|GO:0005737|GO:0012506|GO:0098562|GO:0046983|GO:0050776|GO:0030176|GO:0005783|GO:0010008|GO:0016021|GO:0019538|GO:0031301|GO:0005794|GO:0005768|GO:0005813|GO:0005798|GO:0031410|GO:0071556|GO:0005815|GO:0005773|GO:0016023|GO:0031981|GO:0071458|GO:0006508|GO:0031988|GO:0005654|GO:0030659|GO:0000139|GO:0005856|GO:0005634|GO:0042803|GO:0015629|GO:0000323|GO:0033619|GO:0015630|GO:0070001|GO:0004175|GO:0005765|GO:0006509|GO:0031293|GO:0005764|GO:0004190|GO:0042500 immune system process|cell|membrane|metabolic process|response to stimulus|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|immune response|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|regulation of immune system process|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|identical protein binding|cytoplasmic side of endoplasmic reticulum membrane|Golgi-associated vesicle membrane|vesicle|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|peptidase activity|vacuolar membrane|cytoplasm|vesicle membrane|cytoplasmic side of membrane|protein dimerization activity|regulation of immune response|integral component of endoplasmic reticulum membrane|endoplasmic reticulum|endosome membrane|integral component of membrane|protein metabolic process|integral component of organelle membrane|Golgi apparatus|endosome|centrosome|Golgi-associated vesicle|cytoplasmic vesicle|integral component of lumenal side of endoplasmic reticulum membrane|microtubule organizing center|vacuole|cytoplasmic, membrane-bounded vesicle|nuclear lumen|integral component of cytoplasmic side of endoplasmic reticulum membrane|proteolysis|membrane-bounded vesicle|nucleoplasm|cytoplasmic vesicle membrane|Golgi membrane|cytoskeleton|nucleus|protein homodimerization activity|actin cytoskeleton|lytic vacuole|membrane protein proteolysis|microtubule cytoskeleton|aspartic-type peptidase activity|endopeptidase activity|lysosomal membrane|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|lysosome|aspartic-type endopeptidase activity|aspartic endopeptidase activity, intramembrane cleaving - - - - 19:2328615-2354806 186 192 299 519 574 618 1.04016436531732 0.9758211715694 1.5075608296596 2.60048544819641 2.63372097875182 3.23897054045451 1.17451545551544 2.82439232246758 -1.26587480223108 2.38663752515923e-07 3.39450579686059e-06 DOWN ENSG00000121691 CAT catalase [Source:HGNC Symbol;Acc:HGNC:1516] GO:0016209|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0014854|GO:0097159|GO:0009892|GO:0014823|GO:0030055|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0048037|GO:0071944|GO:0009605|GO:0009893|GO:0004601|GO:0016787|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0044255|GO:0098869|GO:0006725|GO:0001822|GO:0009888|GO:0009314|GO:0035295|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0048513|GO:0051302|GO:0005102|GO:0034641|GO:0015980|GO:0005924|GO:0044281|GO:0005912|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0004096|GO:0005758|GO:0016810|GO:0072593|GO:0009966|GO:0046983|GO:0009890|GO:0042744|GO:0006979|GO:0060548|GO:0042493|GO:0010646|GO:0006139|GO:0055086|GO:0007154|GO:0044092|GO:0006629|GO:0007165|GO:0005783|GO:0070062|GO:0001503|GO:0009725|GO:0008219|GO:0050662|GO:0001666|GO:0000166|GO:0006091|GO:0051781|GO:0051301|GO:0048869|GO:0010035|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0016684|GO:0055093|GO:0005794|GO:0051090|GO:0055114|GO:0007568|GO:0009636|GO:0007584|GO:1902533|GO:0005740|GO:0005829|GO:0009743|GO:0010468|GO:0034645|GO:0046486|GO:0046872|GO:0042743|GO:0020037|GO:0033993|GO:0072164|GO:0042542|GO:0001655|GO:0010629|GO:0043069|GO:0051252|GO:0006066|GO:0016811|GO:1901652|GO:0005773|GO:0010628|GO:0010038|GO:0020027|GO:0050661|GO:0072001|GO:0033273|GO:0001649|GO:0051091|GO:0006638|GO:0033591|GO:0043434|GO:0033197|GO:0010193|GO:0070848|GO:0005739|GO:0043433|GO:0006461|GO:0008202|GO:0070542|GO:0012501|GO:0014070|GO:0060429|GO:0000302|GO:0006796|GO:0035556|GO:0072073|GO:0010467|GO:0071310|GO:0031328|GO:0045333|GO:0019439|GO:0009059|GO:0030154|GO:0001823|GO:1902531|GO:0016070|GO:0031667|GO:0046434|GO:0010557|GO:0009416|GO:0042803|GO:0043067|GO:0048545|GO:0097305|GO:0005778|GO:0005925|GO:0009642|GO:0045893|GO:0009060|GO:0009411|GO:0001657|GO:0051259|GO:0046686|GO:0000323|GO:0045892|GO:0005777|GO:0014068|GO:0009117|GO:0032774|GO:2001141|GO:0034284|GO:0071363|GO:0072163|GO:0005782|GO:0043627|GO:0051092|GO:1902679|GO:0048017|GO:0045471|GO:0016125|GO:0006163|GO:0032355|GO:0042981|GO:0010288|GO:0032088|GO:0043066|GO:0080184|GO:0006144|GO:0032868|GO:0006639|GO:0009166|GO:0014066|GO:0004046|GO:0033189|GO:0006351|GO:0006915|GO:0006355|GO:0006195|GO:1903507|GO:0048015|GO:0005764|GO:1903506|GO:0008203|GO:0009650|GO:0051260|GO:0051262|GO:0006641|GO:0051289|GO:0014065 antioxidant activity|developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|response to inactivity|organic cyclic compound binding|negative regulation of metabolic process|response to activity|cell-substrate junction|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cofactor binding|cell periphery|response to external stimulus|positive regulation of metabolic process|peroxidase activity|hydrolase activity|biosynthetic process|extracellular space|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|cellular lipid metabolic process|cellular oxidant detoxification|cellular aromatic compound metabolic process|kidney development|tissue development|response to radiation|tube development|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|animal organ development|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|cell-substrate adherens junction|small molecule metabolic process|adherens junction|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|catalase activity|mitochondrial intermembrane space|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|reactive oxygen species metabolic process|regulation of signal transduction|protein dimerization activity|negative regulation of biosynthetic process|hydrogen peroxide catabolic process|response to oxidative stress|negative regulation of cell death|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|negative regulation of molecular function|lipid metabolic process|signal transduction|endoplasmic reticulum|extracellular exosome|ossification|response to hormone|cell death|coenzyme binding|response to hypoxia|nucleotide binding|generation of precursor metabolites and energy|positive regulation of cell division|cell division|cellular developmental process|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|oxidoreductase activity, acting on peroxide as acceptor|response to hyperoxia|Golgi apparatus|regulation of sequence-specific DNA binding transcription factor activity|oxidation-reduction process|aging|response to toxic substance|response to nutrient|positive regulation of intracellular signal transduction|mitochondrial envelope|cytosol|response to carbohydrate|regulation of gene expression|cellular macromolecule biosynthetic process|glycerolipid metabolic process|metal ion binding|hydrogen peroxide metabolic process|heme binding|response to lipid|mesonephric tubule development|response to hydrogen peroxide|urogenital system development|negative regulation of gene expression|negative regulation of programmed cell death|regulation of RNA metabolic process|alcohol metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|response to peptide|vacuole|positive regulation of gene expression|response to metal ion|hemoglobin metabolic process|NADP binding|renal system development|response to vitamin|osteoblast differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|neutral lipid metabolic process|response to L-ascorbic acid|response to peptide hormone|response to vitamin E|response to ozone|response to growth factor|mitochondrion|negative regulation of sequence-specific DNA binding transcription factor activity|protein complex assembly|steroid metabolic process|response to fatty acid|programmed cell death|response to organic cyclic compound|epithelium development|response to reactive oxygen species|phosphate-containing compound metabolic process|intracellular signal transduction|kidney epithelium development|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|cellular respiration|aromatic compound catabolic process|macromolecule biosynthetic process|cell differentiation|mesonephros development|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|organophosphate catabolic process|positive regulation of macromolecule biosynthetic process|response to light stimulus|protein homodimerization activity|regulation of programmed cell death|response to steroid hormone|response to alcohol|peroxisomal membrane|focal adhesion|response to light intensity|positive regulation of transcription, DNA-templated|aerobic respiration|response to UV|ureteric bud development|protein oligomerization|response to cadmium ion|lytic vacuole|negative regulation of transcription, DNA-templated|peroxisome|positive regulation of phosphatidylinositol 3-kinase signaling|nucleotide metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|response to monosaccharide|cellular response to growth factor stimulus|mesonephric epithelium development|peroxisomal matrix|response to estrogen|positive regulation of NF-kappaB transcription factor activity|negative regulation of RNA biosynthetic process|inositol lipid-mediated signaling|response to ethanol|sterol metabolic process|purine nucleotide metabolic process|response to estradiol|regulation of apoptotic process|response to lead ion|negative regulation of NF-kappaB transcription factor activity|negative regulation of apoptotic process|response to phenylpropanoid|purine nucleobase metabolic process|response to insulin|acylglycerol metabolic process|nucleotide catabolic process|regulation of phosphatidylinositol 3-kinase signaling|aminoacylase activity|response to vitamin A|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|purine nucleotide catabolic process|negative regulation of nucleic acid-templated transcription|phosphatidylinositol-mediated signaling|lysosome|regulation of nucleic acid-templated transcription|cholesterol metabolic process|UV protection|protein homooligomerization|protein tetramerization|triglyceride metabolic process|protein homotetramerization|phosphatidylinositol 3-kinase signaling K03781 catalase[1.11.1.6] hsa04068|hsa01200|hsa04211|hsa04146|hsa04213|hsa05014|hsa00380|hsa00630 FoxO signaling pathway - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)|Tryptophan metabolism - Homo sapiens (human)|Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) 11:34438925-34472062 420 424 770 1227 1287 1725 6.11432144847832 5.60977092628961 10.1065716852744 16.0044678660215 15.3725286174941 23.5351504823309 7.27688802001411 18.3040489886155 -1.33076930327857 2.39325157621821e-07 3.40229202649611e-06 DOWN ENSG00000089195 TRMT6 tRNA methyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:20900] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0032259|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0043234|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0003723|GO:0043412|GO:0001510|GO:0031981|GO:1990234|GO:0005654|GO:0043527|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0034660|GO:0009451|GO:0031515|GO:0044822|GO:0030488|GO:0006400|GO:0006399|GO:0008033 macromolecular complex|cell|cellular process|metabolic process|binding|methylation|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|RNA binding|macromolecule modification|RNA methylation|nuclear lumen|transferase complex|nucleoplasm|tRNA methyltransferase complex|gene expression|RNA metabolic process|nucleus|RNA processing|ncRNA metabolic process|RNA modification|tRNA (m1A) methyltransferase complex|poly(A) RNA binding|tRNA methylation|tRNA modification|tRNA metabolic process|tRNA processing - - - - 20:5937235-5950558 3214 3026 1985 1443 1177 911 37.4174247971077 32.0167247347806 20.8354392972295 15.0519191208654 11.2427503855947 9.93975145624499 30.0898629430393 12.0781403209017 1.31687919625259 2.39570521327143e-07 3.40415913550716e-06 UP ENSG00000138764 CCNG2 cyclin G2 [Source:HGNC Symbol;Acc:HGNC:1593] GO:0005623|GO:0009987|GO:0050794|GO:0016043|GO:0005622|GO:0051726|GO:0007049|GO:0022402|GO:0005737|GO:0051301|GO:0006996|GO:0000075|GO:1903047|GO:0000278|GO:0007067 cell|cellular process|regulation of cellular process|cellular component organization|intracellular|regulation of cell cycle|cell cycle|cell cycle process|cytoplasm|cell division|organelle organization|cell cycle checkpoint|mitotic cell cycle process|mitotic cell cycle|mitotic nuclear division K10146 cyclin G2[-] hsa04068|hsa04115 FoxO signaling pathway - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 4:77157151-77433388 192 193 395 669 676 867 1.35543978997372 1.23827142973236 2.51414136021371 4.23157163015982 3.91555174994837 5.73622095319587 1.70261752663993 4.62778144443469 -1.44256634546819 2.40824608483787e-07 3.42035102838961e-06 DOWN ENSG00000018236 CNTN1 contactin 1 [Source:HGNC Symbol;Acc:HGNC:2171] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0051050|GO:0043209|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0030246|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0031225|GO:0006935|GO:0045595|GO:0048468|GO:0006810|GO:0051130|GO:0007275|GO:0048513|GO:0030902|GO:0043270|GO:0031982|GO:0031325|GO:0051128|GO:0007420|GO:0045597|GO:0060322|GO:0006928|GO:0007154|GO:0022037|GO:0007165|GO:0070062|GO:0030030|GO:0021549|GO:0001948|GO:0048869|GO:0019538|GO:0098857|GO:0031323|GO:0032268|GO:0000902|GO:0031175|GO:0031344|GO:0010468|GO:0007166|GO:0043412|GO:0007417|GO:0010720|GO:0031346|GO:0000904|GO:0010628|GO:0036211|GO:0006811|GO:0050769|GO:0051247|GO:0043269|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0010765|GO:0032990|GO:0007399|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:0045121|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0031401|GO:0006812|GO:0016310|GO:0061564|GO:0007219|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0010976|GO:0045666|GO:0007409|GO:0006468|GO:0048699|GO:0042325|GO:0001932|GO:0018193|GO:0002028|GO:0030001|GO:0001934|GO:0045664|GO:0015672|GO:0042327|GO:0050731|GO:0050730|GO:0006814|GO:0018108 locomotion|developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|positive regulation of transport|myelin sheath|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|carbohydrate binding|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|anchored component of membrane|chemotaxis|regulation of cell differentiation|cell development|transport|positive regulation of cellular component organization|multicellular organism development|animal organ development|hindbrain development|positive regulation of ion transport|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|brain development|positive regulation of cell differentiation|head development|movement of cell or subcellular component|cell communication|metencephalon development|signal transduction|extracellular exosome|cell projection organization|cerebellum development|glycoprotein binding|cellular developmental process|protein metabolic process|membrane microdomain|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|regulation of cell projection organization|regulation of gene expression|cell surface receptor signaling pathway|macromolecule modification|central nervous system development|positive regulation of cell development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|positive regulation of gene expression|protein modification process|ion transport|positive regulation of neurogenesis|positive regulation of protein metabolic process|regulation of ion transport|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|positive regulation of sodium ion transport|cell part morphogenesis|nervous system development|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|membrane raft|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|positive regulation of protein modification process|cation transport|phosphorylation|axon development|Notch signaling pathway|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|positive regulation of neuron differentiation|axonogenesis|protein phosphorylation|generation of neurons|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|regulation of sodium ion transport|metal ion transport|positive regulation of protein phosphorylation|regulation of neuron differentiation|monovalent inorganic cation transport|positive regulation of phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|sodium ion transport|peptidyl-tyrosine phosphorylation K06759 contactin 1[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 12:40692442-41072418 2 6 2 19 28 37 0.0121264465880619 0.0330639304366893 0.0109340051425876 0.103223396230399 0.139299924239214 0.210256698609393 0.0187081273891129 0.150926673026335 -3.01211073080541 2.45292610285314e-07 3.48215196740739e-06 DOWN ENSG00000124103 FAM209A family with sequence similarity 209 member A [Source:HGNC Symbol;Acc:HGNC:16100] GO:0005623|GO:0016020|GO:0005576|GO:1903561|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0031982|GO:0043231|GO:0070062|GO:0016021|GO:0005634 cell|membrane|extracellular region|extracellular vesicle|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|vesicle|intracellular membrane-bounded organelle|extracellular exosome|integral component of membrane|nucleus - - - - 20:56517187-56526142 22 23 16 3 4 2 0.986813345471483 0.937627376332573 0.647082328438438 0.120551996648371 0.147201437945176 0.0840656250827116 0.857174350080831 0.117273019892086 2.86971753802119 2.46743675540002e-07 3.50108635435894e-06 UP ENSG00000133107 TRPC4 transient receptor potential cation channel, subfamily C, member 4 [Source:HGNC Symbol;Acc:HGNC:12336] GO:0040011|GO:0032502|GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0036094|GO:0022857|GO:0043229|GO:0043167|GO:0009986|GO:0005911|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0006935|GO:0008013|GO:0048468|GO:0016323|GO:0006810|GO:0005938|GO:0044853|GO:0007275|GO:0043168|GO:0005887|GO:0043178|GO:0005737|GO:0006928|GO:0042592|GO:0050839|GO:0019725|GO:0022891|GO:0031226|GO:1902495|GO:0055085|GO:0030030|GO:0048869|GO:0016021|GO:0098857|GO:0005901|GO:0000902|GO:0005829|GO:0031175|GO:0007417|GO:0048878|GO:0000904|GO:0015267|GO:0006811|GO:0055082|GO:0015075|GO:0034702|GO:0043269|GO:0045296|GO:0032990|GO:0007399|GO:0046903|GO:0097485|GO:0030154|GO:0048858|GO:0045121|GO:0070679|GO:0005856|GO:0034220|GO:0048666|GO:0030182|GO:0007411|GO:0098655|GO:0006820|GO:0015711|GO:0005216|GO:0010001|GO:0034703|GO:0006812|GO:0061564|GO:0046942|GO:0048709|GO:0050801|GO:0006865|GO:0022008|GO:0048667|GO:0030863|GO:0048812|GO:0046717|GO:0006873|GO:0008324|GO:0015718|GO:0007409|GO:0048699|GO:0015812|GO:0014051|GO:0034704|GO:0042063|GO:0022890|GO:0030001|GO:0051924|GO:0005261|GO:0030003|GO:0005262|GO:0070588|GO:0055065|GO:0006875|GO:0046873|GO:0015279|GO:0006874|GO:0006816|GO:0055074|GO:0015085|GO:0006828|GO:0051480|GO:0070509 locomotion|developmental process|macromolecular complex|transporter activity|cell|membrane|cellular process|cell junction|response to stimulus|binding|small molecule binding|transmembrane transporter activity|intracellular organelle|ion binding|cell surface|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|chemotaxis|beta-catenin binding|cell development|basolateral plasma membrane|transport|cell cortex|plasma membrane raft|multicellular organism development|anion binding|integral component of plasma membrane|alcohol binding|cytoplasm|movement of cell or subcellular component|homeostatic process|cell adhesion molecule binding|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|transmembrane transport|cell projection organization|cellular developmental process|integral component of membrane|membrane microdomain|caveola|cell morphogenesis|cytosol|neuron projection development|central nervous system development|chemical homeostasis|cell morphogenesis involved in differentiation|channel activity|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|ion channel complex|regulation of ion transport|cadherin binding|cell part morphogenesis|nervous system development|secretion|neuron projection guidance|cell differentiation|cell projection morphogenesis|membrane raft|inositol 1,4,5 trisphosphate binding|cytoskeleton|ion transmembrane transport|neuron development|neuron differentiation|axon guidance|cation transmembrane transport|anion transport|organic anion transport|ion channel activity|glial cell differentiation|cation channel complex|cation transport|axon development|carboxylic acid transport|oligodendrocyte differentiation|ion homeostasis|amino acid transport|neurogenesis|cell morphogenesis involved in neuron differentiation|cortical cytoskeleton|neuron projection morphogenesis|acid secretion|cellular ion homeostasis|cation transmembrane transporter activity|monocarboxylic acid transport|axonogenesis|generation of neurons|gamma-aminobutyric acid transport|gamma-aminobutyric acid secretion|calcium channel complex|gliogenesis|inorganic cation transmembrane transporter activity|metal ion transport|regulation of calcium ion transport|cation channel activity|cellular cation homeostasis|calcium channel activity|calcium ion transmembrane transport|metal ion homeostasis|cellular metal ion homeostasis|metal ion transmembrane transporter activity|store-operated calcium channel activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|calcium ion transmembrane transporter activity|manganese ion transport|regulation of cytosolic calcium ion concentration|calcium ion import K04967 transient receptor potential cation channel subfamily C member 4[-] hsa04360 Axon guidance - Homo sapiens (human) 13:37636636-37870425 7 10 30 86 86 63 0.0564294098132882 0.0732618827111903 0.218037015560988 0.621146549236655 0.568807644711542 0.475953911800462 0.115909436028489 0.55530270191622 -2.26027639666238 2.47120483138183e-07 3.50476717511036e-06 DOWN ENSG00000089123 TASP1 taspase 1 [Source:HGNC Symbol;Acc:HGNC:15859] GO:0009987|GO:0008152|GO:0003824|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009893|GO:0016787|GO:0009058|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0008233|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010628|GO:0006508|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0045893|GO:0032774|GO:2001141|GO:0004175|GO:0006351|GO:0006355|GO:0004298|GO:1903506 cellular process|metabolic process|catalytic activity|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|positive regulation of metabolic process|hydrolase activity|biosynthetic process|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|peptidase activity|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|positive regulation of gene expression|proteolysis|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|endopeptidase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|threonine-type endopeptidase activity|regulation of nucleic acid-templated transcription - - - - 20:13389392-13638940 99 132 174 340 381 348 2.28928437598509 2.77408430024098 3.62769338150154 7.0443885537729 7.22868839765061 7.5417883550874 2.8970206859092 7.27162176883697 -1.32770717407003 2.48139703160037e-07 3.51755113871782e-06 DOWN ENSG00000248932 RP11-319G6.1 - - - - - - - 3:139389815-139583319 7 8 11 36 42 47 0.141597961427396 0.147068463435103 0.200607720270798 0.652458271556764 0.697057298902489 0.891007473049803 0.163091381711099 0.746841014503019 -2.19512061139859 2.48348345995787e-07 3.51883793135179e-06 DOWN ENSG00000181896 ZNF101 zinc finger protein 101 [Source:HGNC Symbol;Acc:HGNC:12881] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:19668796-19683509 114 141 132 59 48 48 0.666613519201802 0.749321320807363 0.69591655935397 0.309115824294055 0.230289689652089 0.263051903664783 0.703950466454378 0.267485805870309 1.39601158009441 2.56212560724911e-07 3.62510416487275e-06 UP ENSG00000184271 POU6F1 POU class 6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9224] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0007507|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0007420|GO:0061061|GO:0043231|GO:0060322|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0072358|GO:0007417|GO:0051252|GO:0010467|GO:0007399|GO:0009059|GO:0007517|GO:0016070|GO:0072359|GO:0005856|GO:0005634|GO:0015629|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|heart development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|brain development|muscle structure development|intracellular membrane-bounded organelle|head development|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cardiovascular system development|central nervous system development|regulation of RNA metabolic process|gene expression|nervous system development|macromolecule biosynthetic process|muscle organ development|RNA metabolic process|circulatory system development|cytoskeleton|nucleus|actin cytoskeleton|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 12:51186936-51217693 31 45 33 4 5 13 0.253536806892874 0.334484798036304 0.24333938509824 0.0293124535122371 0.0335529997946463 0.0996480198186078 0.277120330009139 0.0541711577084971 2.35491572468258 2.56567775770235e-07 3.62841041110591e-06 UP ENSG00000112130 RNF8 ring finger protein 8, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:10071] GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0030496|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0019953|GO:0044237|GO:0003006|GO:0016043|GO:0043227|GO:0009893|GO:0032504|GO:0009058|GO:0016874|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048609|GO:0019222|GO:0042802|GO:0002250|GO:0007049|GO:0006281|GO:0016445|GO:0006725|GO:0042393|GO:0048468|GO:0009314|GO:0022402|GO:1901360|GO:2001022|GO:0045190|GO:0007275|GO:0016570|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0002377|GO:0048515|GO:0001775|GO:0002312|GO:0046983|GO:0002263|GO:0009890|GO:0003682|GO:0006139|GO:0046649|GO:0007276|GO:0002366|GO:0019787|GO:0051301|GO:0000151|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0007281|GO:0031323|GO:0002443|GO:0006996|GO:0051276|GO:0042113|GO:0010468|GO:0007286|GO:0034645|GO:0048232|GO:0046872|GO:0000725|GO:1903047|GO:0043412|GO:0030163|GO:0010629|GO:0004842|GO:0016447|GO:0051252|GO:0006325|GO:0044265|GO:0006302|GO:0036211|GO:0000278|GO:0036297|GO:0045739|GO:0035861|GO:0031981|GO:2001020|GO:1990234|GO:0006508|GO:0016574|GO:0005654|GO:0006259|GO:0005694|GO:0002460|GO:0006282|GO:0051054|GO:0010212|GO:0002381|GO:0044267|GO:0007067|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0042803|GO:0006974|GO:0044389|GO:0031625|GO:0007283|GO:0006303|GO:0044257|GO:0000724|GO:0000781|GO:0045892|GO:0032774|GO:2001141|GO:0034728|GO:1902679|GO:0033522|GO:0051603|GO:0006310|GO:0046914|GO:0016568|GO:0033523|GO:0019724|GO:0006464|GO:0002204|GO:0006351|GO:0006355|GO:0043486|GO:0016064|GO:0006366|GO:0032784|GO:1903507|GO:0032785|GO:0006357|GO:0019941|GO:1903506|GO:0070535|GO:0006354|GO:0016444|GO:0006338|GO:0000122|GO:0008270|GO:0032446|GO:0006511|GO:0006368|GO:0034243|GO:0034244|GO:0043044|GO:0016567|GO:0051865|GO:0000209|GO:0070534|GO:0070936 developmental process|macromolecular complex|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|midbody|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|immune response|response to abiotic stimulus|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|ligase activity|intracellular|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|identical protein binding|adaptive immune response|cell cycle|DNA repair|somatic diversification of immunoglobulins|cellular aromatic compound metabolic process|histone binding|cell development|response to radiation|cell cycle process|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|isotype switching|multicellular organism development|histone modification|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|immunoglobulin production|spermatid differentiation|cell activation|B cell activation involved in immune response|protein dimerization activity|cell activation involved in immune response|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|lymphocyte activation|gamete generation|leukocyte activation involved in immune response|ubiquitin-like protein transferase activity|cell division|ubiquitin ligase complex|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|leukocyte mediated immunity|organelle organization|chromosome organization|B cell activation|regulation of gene expression|spermatid development|cellular macromolecule biosynthetic process|male gamete generation|metal ion binding|recombinational repair|mitotic cell cycle process|macromolecule modification|protein catabolic process|negative regulation of gene expression|ubiquitin-protein transferase activity|somatic recombination of immunoglobulin gene segments|regulation of RNA metabolic process|chromatin organization|cellular macromolecule catabolic process|double-strand break repair|protein modification process|mitotic cell cycle|interstrand cross-link repair|positive regulation of DNA repair|site of double-strand break|nuclear lumen|regulation of response to DNA damage stimulus|transferase complex|proteolysis|histone ubiquitination|nucleoplasm|DNA metabolic process|chromosome|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|regulation of DNA repair|positive regulation of DNA metabolic process|response to ionizing radiation|immunoglobulin production involved in immunoglobulin mediated immune response|cellular protein metabolic process|mitotic nuclear division|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|protein homodimerization activity|cellular response to DNA damage stimulus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|spermatogenesis|double-strand break repair via nonhomologous end joining|cellular protein catabolic process|double-strand break repair via homologous recombination|chromosome, telomeric region|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nucleosome organization|negative regulation of RNA biosynthetic process|histone H2A ubiquitination|proteolysis involved in cellular protein catabolic process|DNA recombination|transition metal ion binding|chromatin modification|histone H2B ubiquitination|B cell mediated immunity|cellular protein modification process|somatic recombination of immunoglobulin genes involved in immune response|transcription, DNA-templated|regulation of transcription, DNA-templated|histone exchange|immunoglobulin mediated immune response|transcription from RNA polymerase II promoter|regulation of DNA-templated transcription, elongation|negative regulation of nucleic acid-templated transcription|negative regulation of DNA-templated transcription, elongation|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|histone H2A K63-linked ubiquitination|DNA-templated transcription, elongation|somatic cell DNA recombination|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|transcription elongation from RNA polymerase II promoter|regulation of transcription elongation from RNA polymerase II promoter|negative regulation of transcription elongation from RNA polymerase II promoter|ATP-dependent chromatin remodeling|protein ubiquitination|protein autoubiquitination|protein polyubiquitination|protein K63-linked ubiquitination|protein K48-linked ubiquitination - - - - 6:37353972-37394738 806 889 725 420 467 286 5.14148274634114 5.15389149808516 4.16971048799954 2.40049241950599 2.44421001810416 1.70981339593661 4.82169491080861 2.18483861118225 1.14201365314347 2.56813396472552e-07 3.63016436472138e-06 UP ENSG00000146457 WTAP Wilms tumor 1 associated protein [Source:HGNC Symbol;Acc:HGNC:16846] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0032259|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0005635|GO:0006139|GO:0031965|GO:0031323|GO:0010468|GO:0043412|GO:0051252|GO:0001510|GO:0036396|GO:0031981|GO:1990234|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0050684|GO:0043484|GO:0009451|GO:0016604|GO:0016071|GO:0080009|GO:0016607|GO:0016556|GO:0048024|GO:0006397|GO:0008380|GO:0000375|GO:0000381|GO:0000398|GO:0000380 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|methylation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|nucleobase-containing compound metabolic process|nuclear membrane|regulation of cellular metabolic process|regulation of gene expression|macromolecule modification|regulation of RNA metabolic process|RNA methylation|MIS complex|nuclear lumen|transferase complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|regulation of mRNA processing|regulation of RNA splicing|RNA modification|nuclear body|mRNA metabolic process|mRNA methylation|nuclear speck|mRNA modification|regulation of mRNA splicing, via spliceosome|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|alternative mRNA splicing, via spliceosome - - - - 6:159725585-159756319 2124 2301 1587 1008 1100 696 15.2641516917136 15.0284765880874 10.2827524086977 6.49047235685054 6.48603076535541 4.68766241556687 13.5251268961662 5.88805517925761 1.19977903321802 2.56988197921776e-07 3.63091607229375e-06 UP ENSG00000261239 ANKRD26P1 ankyrin repeat domain 26 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:32955] - - - - - - 16:46469341-46569097 20 8 10 0 1 0 0.166322304245497 0.0604630162982078 0.0749800752371426 0 0.0068261494926349 0 0.100588465260282 0.00227538316421163 5.46621155775304 2.58143415132874e-07 3.64378889615925e-06 UP ENSG00000159217 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:28866] GO:0032502|GO:0032991|GO:0045202|GO:0005623|GO:0045182|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0030427|GO:0043227|GO:0031252|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0006810|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0010610|GO:0030900|GO:0030426|GO:0033554|GO:0007420|GO:0001817|GO:0043231|GO:0070937|GO:0005737|GO:0001816|GO:0030529|GO:0060322|GO:0043005|GO:0030027|GO:0009890|GO:0043197|GO:0036477|GO:0061351|GO:0006403|GO:0021543|GO:0000166|GO:0021537|GO:0044249|GO:0019827|GO:0019538|GO:0043487|GO:0031324|GO:0031323|GO:0035770|GO:0042107|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0042089|GO:0006518|GO:0003723|GO:0030424|GO:0044309|GO:0007417|GO:0010629|GO:0097150|GO:0032269|GO:0042035|GO:0030425|GO:0048471|GO:0021846|GO:0030175|GO:0050658|GO:0043603|GO:0022013|GO:0044267|GO:0010467|GO:0007399|GO:0051246|GO:0009059|GO:0005634|GO:0036464|GO:0043488|GO:0043043|GO:0051028|GO:0017148|GO:0048255|GO:0010608|GO:0006412|GO:0006417|GO:0044822|GO:0010494|GO:0070934|GO:0003729|GO:0048027|GO:0003730 developmental process|macromolecular complex|synapse|cell|translation regulator activity|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|site of polarized growth|membrane-bounded organelle|cell leading edge|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|transport|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|regulation of mRNA stability involved in response to stress|forebrain development|growth cone|cellular response to stress|brain development|regulation of cytokine production|intracellular membrane-bounded organelle|CRD-mediated mRNA stability complex|cytoplasm|cytokine production|intracellular ribonucleoprotein complex|head development|neuron projection|lamellipodium|negative regulation of biosynthetic process|dendritic spine|somatodendritic compartment|neural precursor cell proliferation|RNA localization|pallium development|nucleotide binding|telencephalon development|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|regulation of RNA stability|negative regulation of cellular metabolic process|regulation of cellular metabolic process|ribonucleoprotein granule|cytokine metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|cytokine biosynthetic process|peptide metabolic process|RNA binding|axon|neuron spine|central nervous system development|negative regulation of gene expression|neuronal stem cell population maintenance|negative regulation of cellular protein metabolic process|regulation of cytokine biosynthetic process|dendrite|perinuclear region of cytoplasm|cell proliferation in forebrain|filopodium|RNA transport|cellular amide metabolic process|pallium cell proliferation in forebrain|cellular protein metabolic process|gene expression|nervous system development|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|cytoplasmic ribonucleoprotein granule|regulation of mRNA stability|peptide biosynthetic process|mRNA transport|negative regulation of translation|mRNA stabilization|posttranscriptional regulation of gene expression|translation|regulation of translation|poly(A) RNA binding|cytoplasmic stress granule|CRD-mediated mRNA stabilization|mRNA binding|mRNA 5'-UTR binding|mRNA 3'-UTR binding K17391 insulin-like growth factor 2 mRNA-binding protein 1[-] hsa05206 MicroRNAs in cancer - Homo sapiens (human) 17:48997412-49055650 739 830 928 1819 2049 1660 4.94228245658776 5.04476898694747 5.59558447960803 10.8996777668529 11.2432856357408 10.404477508754 5.19421197438109 10.8491469704492 -1.06260481686403 2.58916630438664e-07 3.6512692241679e-06 DOWN ENSG00000243927 MRPS6 mitochondrial ribosomal protein S6 [Source:HGNC Symbol;Acc:HGNC:14051] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0031090|GO:0019866|GO:0003676|GO:0034641|GO:0005761|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0031966|GO:0044249|GO:0019538|GO:0006996|GO:0005740|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0005840|GO:0005743|GO:0005759|GO:0005739|GO:0070124|GO:0043603|GO:0044267|GO:0010467|GO:0005763|GO:0009059|GO:0015935|GO:0032543|GO:0043241|GO:0043043|GO:0070125|GO:0019843|GO:0006412|GO:0070126|GO:0006414|GO:0070181|GO:0043624|GO:0006415 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|organelle membrane|organelle inner membrane|nucleic acid binding|cellular nitrogen compound metabolic process|mitochondrial ribosome|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|cellular biosynthetic process|protein metabolic process|organelle organization|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|ribosome|mitochondrial inner membrane|mitochondrial matrix|mitochondrion|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|mitochondrial small ribosomal subunit|macromolecule biosynthetic process|small ribosomal subunit|mitochondrial translation|protein complex disassembly|peptide biosynthetic process|mitochondrial translational elongation|rRNA binding|translation|mitochondrial translational termination|translational elongation|small ribosomal subunit rRNA binding|cellular protein complex disassembly|translational termination K02990 small subunit ribosomal protein S6[-] hsa03010 Ribosome - Homo sapiens (human) 21:34073224-34143034 138 185 233 454 517 431 1.67582755596379 2.04174786425506 2.55105905567188 4.93973310048451 5.15119787129581 4.90519358147073 2.08954482529691 4.99870818441702 -1.25836659959139 2.58917965685115e-07 3.6512692241679e-06 DOWN ENSG00000182168 UNC5C unc-5 netrin receptor C [Source:HGNC Symbol;Acc:HGNC:12569] GO:0040011|GO:0032502|GO:0004871|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0050794|GO:0040012|GO:0038023|GO:0048870|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0006935|GO:0048468|GO:0010941|GO:0007275|GO:0048513|GO:0007420|GO:0010942|GO:0004888|GO:0060322|GO:0006928|GO:0043005|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0008219|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0000902|GO:0031175|GO:0007166|GO:0007417|GO:0000904|GO:0030334|GO:0012501|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0043068|GO:0005042|GO:0043067|GO:0048666|GO:0030182|GO:0007411|GO:0043065|GO:0061564|GO:0042981|GO:0022008|GO:0048667|GO:0038007|GO:0048812|GO:0006915|GO:0007409|GO:0048699|GO:0033564 locomotion|developmental process|signal transducer activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|regulation of cellular process|regulation of locomotion|signaling receptor activity|cell motility|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|chemotaxis|cell development|regulation of cell death|multicellular organism development|animal organ development|brain development|positive regulation of cell death|transmembrane signaling receptor activity|head development|movement of cell or subcellular component|neuron projection|cell communication|regulation of cellular component movement|cell migration|signal transduction|cell death|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|cell morphogenesis|neuron projection development|cell surface receptor signaling pathway|central nervous system development|cell morphogenesis involved in differentiation|regulation of cell migration|programmed cell death|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|netrin receptor activity|regulation of programmed cell death|neuron development|neuron differentiation|axon guidance|positive regulation of apoptotic process|axon development|regulation of apoptotic process|neurogenesis|cell morphogenesis involved in neuron differentiation|netrin-activated signaling pathway|neuron projection morphogenesis|apoptotic process|axonogenesis|generation of neurons|anterior/posterior axon guidance K07521 netrin receptor unc-5[-] hsa04360 Axon guidance - Homo sapiens (human) 4:95162504-95549206 0 2 2 14 38 13 0 0.0109490423365528 0.0108623098010242 0.0755626276501478 0.187811692635822 0.0733931468458775 0.00727045071252567 0.112255822377282 -3.948601661991 2.59226389394956e-07 3.65389264825166e-06 DOWN ENSG00000175170 FAM182B family with sequence similarity 182 member B [Source:HGNC Symbol;Acc:HGNC:34503] - - - - - - 20:25763466-25868225 5 1 3 24 20 46 0.0564837025255947 0.0102711157356978 0.030549470107517 0.242905835891407 0.185362737072285 0.486984489161137 0.0324347627896032 0.30508435404161 -3.23359540171018 2.61692733476105e-07 3.68691593449535e-06 DOWN ENSG00000035499 DEPDC1B DEP domain containing 1B [Source:HGNC Symbol;Acc:HGNC:24902] GO:0040011|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0048870|GO:0023051|GO:0009893|GO:0030234|GO:0005622|GO:0019222|GO:0008047|GO:0005737|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0016477|GO:0007165|GO:0050790|GO:0009967|GO:0030111|GO:0005829|GO:0005096|GO:0007166|GO:0051345|GO:0030695|GO:0035556|GO:0030177|GO:1902531|GO:0016055|GO:0043087|GO:0043547|GO:0051056|GO:0007264 locomotion|signaling|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|cell motility|regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of metabolic process|enzyme activator activity|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|cell migration|signal transduction|regulation of catalytic activity|positive regulation of signal transduction|regulation of Wnt signaling pathway|cytosol|GTPase activator activity|cell surface receptor signaling pathway|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|positive regulation of Wnt signaling pathway|regulation of intracellular signal transduction|Wnt signaling pathway|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 5:60596912-60700190 190 194 239 513 562 448 2.71459771938829 2.51903385242163 3.07868861063805 6.56700773956684 6.5880566624852 5.99873789476651 2.77077339414932 6.38460076560618 -1.20430768403413 2.63630357333467e-07 3.7107122526324e-06 DOWN ENSG00000140465 CYP1A1 cytochrome P450 family 1 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2595] GO:0032502|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0032451|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0042445|GO:0051707|GO:0043227|GO:0019825|GO:0009607|GO:0009605|GO:0032504|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0048609|GO:1903409|GO:0051726|GO:0007049|GO:0044255|GO:0048565|GO:0009635|GO:0006725|GO:0009888|GO:0022402|GO:0035295|GO:1901360|GO:0006082|GO:0009991|GO:0007275|GO:0009410|GO:0048513|GO:0009624|GO:0046685|GO:0018894|GO:0044281|GO:0070576|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0016705|GO:0009611|GO:0007423|GO:0035902|GO:0072593|GO:0009615|GO:0070988|GO:0045787|GO:0051186|GO:0042493|GO:0009617|GO:0004497|GO:0009812|GO:0006629|GO:0005783|GO:0009404|GO:0006805|GO:0001666|GO:0017144|GO:0016679|GO:0010817|GO:0048869|GO:0032094|GO:0010035|GO:0060137|GO:0044249|GO:0010033|GO:0048732|GO:0055093|GO:0007567|GO:0055114|GO:0007568|GO:0009636|GO:0007584|GO:0090068|GO:0055123|GO:0046872|GO:0042743|GO:0017143|GO:0001654|GO:0020037|GO:0033993|GO:1903047|GO:0042573|GO:0002237|GO:0006720|GO:0006066|GO:0009308|GO:0006631|GO:0019341|GO:0016709|GO:0008395|GO:0044770|GO:0009790|GO:0001889|GO:0010038|GO:0006778|GO:0000278|GO:0033273|GO:0050665|GO:0071466|GO:0007346|GO:0010564|GO:0008299|GO:0005739|GO:0008202|GO:0046677|GO:0014070|GO:0060429|GO:0016712|GO:0009804|GO:0008610|GO:0071310|GO:0019439|GO:0010039|GO:0030154|GO:0017085|GO:0045931|GO:0031667|GO:0032496|GO:0042178|GO:0006690|GO:0006766|GO:0033559|GO:0002138|GO:0009792|GO:0070330|GO:0030855|GO:0043010|GO:0042359|GO:0044772|GO:0001676|GO:0071407|GO:1901990|GO:0070365|GO:1901989|GO:0019369|GO:1901992|GO:0010041|GO:0046914|GO:0019752|GO:1901987|GO:0016711|GO:0033189|GO:0097267|GO:1900087|GO:0005506|GO:0019373|GO:2000045|GO:1902808|GO:1902806|GO:0000082|GO:0016101|GO:0032787|GO:0042904|GO:0001523 developmental process|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|demethylase activity|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|hormone metabolic process|response to other organism|membrane-bounded organelle|oxygen binding|response to biotic stimulus|response to external stimulus|multicellular organism reproduction|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|anatomical structure development|organelle membrane|multicellular organismal reproductive process|reactive oxygen species biosynthetic process|regulation of cell cycle|cell cycle|cellular lipid metabolic process|digestive tract development|response to herbicide|cellular aromatic compound metabolic process|tissue development|cell cycle process|tube development|organic cyclic compound metabolic process|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|response to xenobiotic stimulus|animal organ development|response to nematode|response to arsenic-containing substance|dibenzo-p-dioxin metabolic process|small molecule metabolic process|vitamin D 24-hydroxylase activity|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|response to wounding|sensory organ development|response to immobilization stress|reactive oxygen species metabolic process|response to virus|demethylation|positive regulation of cell cycle|cofactor metabolic process|response to drug|response to bacterium|monooxygenase activity|flavonoid metabolic process|lipid metabolic process|endoplasmic reticulum|toxin metabolic process|xenobiotic metabolic process|response to hypoxia|drug metabolic process|oxidoreductase activity, acting on diphenols and related substances as donors|regulation of hormone levels|cellular developmental process|response to food|response to inorganic substance|maternal process involved in parturition|cellular biosynthetic process|response to organic substance|gland development|response to hyperoxia|parturition|oxidation-reduction process|aging|response to toxic substance|response to nutrient|positive regulation of cell cycle process|digestive system development|metal ion binding|hydrogen peroxide metabolic process|insecticide metabolic process|eye development|heme binding|response to lipid|mitotic cell cycle process|retinoic acid metabolic process|response to molecule of bacterial origin|isoprenoid metabolic process|alcohol metabolic process|amine metabolic process|fatty acid metabolic process|dibenzo-p-dioxin catabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|steroid hydroxylase activity|cell cycle phase transition|embryo development|liver development|response to metal ion|porphyrin-containing compound metabolic process|mitotic cell cycle|response to vitamin|hydrogen peroxide biosynthetic process|cellular response to xenobiotic stimulus|regulation of mitotic cell cycle|regulation of cell cycle process|isoprenoid biosynthetic process|mitochondrion|steroid metabolic process|response to antibiotic|response to organic cyclic compound|epithelium development|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|coumarin metabolic process|lipid biosynthetic process|cellular response to organic substance|aromatic compound catabolic process|response to iron ion|cell differentiation|response to insecticide|positive regulation of mitotic cell cycle|response to nutrient levels|response to lipopolysaccharide|xenobiotic catabolic process|icosanoid metabolic process|vitamin metabolic process|unsaturated fatty acid metabolic process|retinoic acid biosynthetic process|embryo development ending in birth or egg hatching|aromatase activity|epithelial cell differentiation|camera-type eye development|vitamin D metabolic process|mitotic cell cycle phase transition|long-chain fatty acid metabolic process|cellular response to organic cyclic compound|regulation of mitotic cell cycle phase transition|hepatocyte differentiation|positive regulation of cell cycle phase transition|arachidonic acid metabolic process|positive regulation of mitotic cell cycle phase transition|response to iron(III) ion|transition metal ion binding|carboxylic acid metabolic process|regulation of cell cycle phase transition|flavonoid 3'-monooxygenase activity|response to vitamin A|omega-hydroxylase P450 pathway|positive regulation of G1/S transition of mitotic cell cycle|iron ion binding|epoxygenase P450 pathway|regulation of G1/S transition of mitotic cell cycle|positive regulation of cell cycle G1/S phase transition|regulation of cell cycle G1/S phase transition|G1/S transition of mitotic cell cycle|diterpenoid metabolic process|monocarboxylic acid metabolic process|9-cis-retinoic acid biosynthetic process|retinoid metabolic process K07408 cytochrome P450, family 1, subfamily A, polypeptide 1[1.14.14.1] hsa01100|hsa05204|hsa00980|hsa00830|hsa00140|hsa04913|hsa00380 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human)|Ovarian steroidogenesis - Homo sapiens (human)|Tryptophan metabolism - Homo sapiens (human) 15:74719542-74725610 39 43 152 12 12 15 0.370993591501047 0.371756914208964 1.30365746504646 0.102282172039002 0.0936616627578756 0.133731470436602 0.682135990252157 0.10989176841116 2.63397605945813 2.65050421052744e-07 3.72894216310491e-06 UP ENSG00000143786 CNIH3 cornichon family AMPA receptor auxiliary protein 3 [Source:HGNC Symbol;Acc:HGNC:26802] GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0016247|GO:0005622|GO:0005789|GO:0005886|GO:0043234|GO:0012505|GO:0097060|GO:0031090|GO:0006486|GO:0043198|GO:0050804|GO:0042391|GO:0051640|GO:0006810|GO:0098797|GO:0031982|GO:0045211|GO:0022607|GO:0051668|GO:0005887|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0012506|GO:0043235|GO:0006903|GO:0005975|GO:0051656|GO:0043005|GO:0009966|GO:0036477|GO:0030658|GO:0010646|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0005783|GO:0051649|GO:0016021|GO:0044249|GO:0010469|GO:0019538|GO:0005794|GO:0006996|GO:0016192|GO:0051650|GO:0012507|GO:0008328|GO:0034645|GO:0006900|GO:0016050|GO:0007166|GO:0043412|GO:0005793|GO:0006487|GO:0090114|GO:0031410|GO:0033116|GO:0016023|GO:0009100|GO:0036211|GO:0046907|GO:0048199|GO:0006811|GO:0030425|GO:0031988|GO:0034765|GO:0070085|GO:0034702|GO:0006461|GO:0043269|GO:0035556|GO:0030659|GO:1901137|GO:0044267|GO:0000139|GO:0051648|GO:0009059|GO:0022898|GO:0030134|GO:0034220|GO:0009101|GO:0043413|GO:0007215|GO:0048208|GO:0018279|GO:0048193|GO:0032412|GO:0030135|GO:2000311|GO:0032281|GO:0006464|GO:0018193|GO:0043687|GO:0006888|GO:0007268|GO:0007270|GO:0035249 macromolecular complex|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|channel regulator activity|intracellular|endoplasmic reticulum membrane|plasma membrane|protein complex|endomembrane system|synaptic membrane|organelle membrane|protein glycosylation|dendritic shaft|modulation of synaptic transmission|regulation of membrane potential|organelle localization|transport|plasma membrane protein complex|vesicle|postsynaptic membrane|cellular component assembly|localization within membrane|integral component of plasma membrane|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|vesicle membrane|receptor complex|vesicle targeting|carbohydrate metabolic process|establishment of organelle localization|neuron projection|regulation of signal transduction|somatodendritic compartment|transport vesicle membrane|regulation of cell communication|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|membrane organization|signal transduction|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|cellular biosynthetic process|regulation of receptor activity|protein metabolic process|Golgi apparatus|organelle organization|vesicle-mediated transport|establishment of vesicle localization|ER to Golgi transport vesicle membrane|ionotropic glutamate receptor complex|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|cell surface receptor signaling pathway|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation|COPII-coated vesicle budding|cytoplasmic vesicle|endoplasmic reticulum-Golgi intermediate compartment membrane|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|protein modification process|intracellular transport|vesicle targeting, to, from or within Golgi|ion transport|dendrite|membrane-bounded vesicle|regulation of ion transmembrane transport|glycosylation|ion channel complex|protein complex assembly|regulation of ion transport|intracellular signal transduction|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|vesicle localization|macromolecule biosynthetic process|regulation of transmembrane transporter activity|ER to Golgi transport vesicle|ion transmembrane transport|glycoprotein biosynthetic process|macromolecule glycosylation|glutamate receptor signaling pathway|COPII vesicle coating|protein N-linked glycosylation via asparagine|Golgi vesicle transport|regulation of ion transmembrane transporter activity|coated vesicle|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|AMPA glutamate receptor complex|cellular protein modification process|peptidyl-amino acid modification|post-translational protein modification|ER to Golgi vesicle-mediated transport|synaptic transmission|neuron-neuron synaptic transmission|synaptic transmission, glutamatergic - - - - 1:224434660-224740549 46 56 71 157 168 177 0.340827109826478 0.377091119349313 0.474299944405159 1.0422584276848 1.02130904965413 1.22908324956683 0.397406057860317 1.09755024230192 -1.46560121359369 2.65349664590392e-07 3.73067205615999e-06 DOWN ENSG00000182578 CSF1R colony stimulating factor 1 receptor [Source:HGNC Symbol;Acc:HGNC:2433] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0009986|GO:0044237|GO:0051641|GO:0038023|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0031224|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0042802|GO:0060341|GO:0008284|GO:0051272|GO:0042127|GO:1903706|GO:0044255|GO:0008360|GO:0006935|GO:0045087|GO:0045595|GO:0035239|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:0010941|GO:0007275|GO:0048513|GO:0043168|GO:0032940|GO:0006952|GO:0030900|GO:0001882|GO:0016772|GO:0019637|GO:0031325|GO:0051128|GO:2000147|GO:0007420|GO:0001817|GO:0061061|GO:0005887|GO:0045597|GO:0019899|GO:0004888|GO:0032970|GO:0001816|GO:1990682|GO:0060322|GO:0032880|GO:0051222|GO:0006928|GO:0009887|GO:0042592|GO:0009966|GO:0048729|GO:0046983|GO:0045184|GO:0048771|GO:0021988|GO:0048871|GO:0001819|GO:0060548|GO:0010646|GO:0031226|GO:0043085|GO:0008104|GO:0007154|GO:0051270|GO:0021772|GO:0006629|GO:0016477|GO:0007165|GO:0019955|GO:0045124|GO:0008219|GO:0008285|GO:0051047|GO:0050790|GO:0000166|GO:0030030|GO:0034103|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0021537|GO:0043954|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0048732|GO:0006996|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0030879|GO:0046850|GO:0045216|GO:0046486|GO:0007166|GO:0032956|GO:0002009|GO:0035639|GO:0043412|GO:0007010|GO:0030097|GO:0034097|GO:0007417|GO:0032642|GO:0043069|GO:0001894|GO:0001883|GO:0051223|GO:0015031|GO:0022612|GO:0000904|GO:0030334|GO:0051347|GO:0036211|GO:0070201|GO:0060537|GO:0006954|GO:0032549|GO:0050714|GO:0032602|GO:0046849|GO:0050715|GO:0019902|GO:0051046|GO:0009306|GO:0051247|GO:0022604|GO:0016301|GO:0030036|GO:0021872|GO:0050663|GO:0032270|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0032990|GO:0045639|GO:0007399|GO:0060562|GO:0046903|GO:0071310|GO:0097485|GO:0017076|GO:0051246|GO:0031529|GO:0030154|GO:0048858|GO:0030335|GO:0007517|GO:0050707|GO:1902531|GO:0016773|GO:0042803|GO:0043067|GO:0006644|GO:0032722|GO:0045637|GO:0048666|GO:0030182|GO:0090197|GO:0002521|GO:0007411|GO:0002761|GO:0060538|GO:0021953|GO:0019221|GO:0031401|GO:0031532|GO:0060603|GO:0043408|GO:2000249|GO:0005524|GO:0050708|GO:0030554|GO:0016310|GO:0070371|GO:0061564|GO:0019903|GO:0048017|GO:0090195|GO:0051493|GO:0007167|GO:0045453|GO:0045217|GO:0002763|GO:0043410|GO:0042981|GO:0071345|GO:0043066|GO:0004672|GO:0021879|GO:0030099|GO:0014706|GO:0022008|GO:0048667|GO:0004714|GO:0006464|GO:0061180|GO:0048812|GO:0060443|GO:0043549|GO:0006650|GO:0006915|GO:0033674|GO:0038145|GO:0036006|GO:0007259|GO:0002573|GO:0045859|GO:0048015|GO:0045860|GO:0046488|GO:0007409|GO:0045672|GO:0006468|GO:0048699|GO:0007519|GO:0046425|GO:0042325|GO:0005011|GO:0004713|GO:0070374|GO:0001932|GO:0018193|GO:0046427|GO:0001934|GO:0070372|GO:0045670|GO:0042327|GO:0007169|GO:0050731|GO:0050730|GO:0061097|GO:0030225|GO:0030224|GO:0046777|GO:0071902|GO:0007260|GO:0030316|GO:0042531|GO:0071900|GO:0061098|GO:0018108|GO:0042516|GO:0042517|GO:0042503 locomotion|developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|immune response|cell surface|cellular metabolic process|cellular localization|signaling receptor activity|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cellular localization|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|regulation of hemopoiesis|cellular lipid metabolic process|regulation of cell shape|chemotaxis|innate immune response|regulation of cell differentiation|tube morphogenesis|tissue development|cell development|transport|tube development|regulation of cell death|multicellular organism development|animal organ development|anion binding|secretion by cell|defense response|forebrain development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|brain development|regulation of cytokine production|muscle structure development|integral component of plasma membrane|positive regulation of cell differentiation|enzyme binding|transmembrane signaling receptor activity|regulation of actin filament-based process|cytokine production|CSF1-CSF1R complex|head development|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|organ morphogenesis|homeostatic process|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|establishment of protein localization|tissue remodeling|olfactory lobe development|multicellular organismal homeostasis|positive regulation of cytokine production|negative regulation of cell death|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|cell communication|regulation of cellular component movement|olfactory bulb development|lipid metabolic process|cell migration|signal transduction|cytokine binding|regulation of bone resorption|cell death|negative regulation of cell proliferation|positive regulation of secretion|regulation of catalytic activity|nucleotide binding|cell projection organization|regulation of tissue remodeling|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|telencephalon development|cellular component maintenance|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|gland development|organelle organization|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|mammary gland development|regulation of bone remodeling|cell-cell junction organization|glycerolipid metabolic process|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|hemopoiesis|response to cytokine|central nervous system development|regulation of chemokine production|negative regulation of programmed cell death|tissue homeostasis|purine nucleoside binding|regulation of protein transport|protein transport|gland morphogenesis|cell morphogenesis involved in differentiation|regulation of cell migration|positive regulation of transferase activity|protein modification process|regulation of establishment of protein localization|muscle tissue development|inflammatory response|ribonucleoside binding|positive regulation of protein secretion|chemokine production|bone remodeling|positive regulation of cytokine secretion|phosphatase binding|regulation of secretion|protein secretion|positive regulation of protein metabolic process|regulation of cell morphogenesis|kinase activity|actin cytoskeleton organization|forebrain generation of neurons|cytokine secretion|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|positive regulation of myeloid cell differentiation|nervous system development|epithelial tube morphogenesis|secretion|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|regulation of protein metabolic process|ruffle organization|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|muscle organ development|regulation of cytokine secretion|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity|regulation of programmed cell death|phospholipid metabolic process|positive regulation of chemokine production|regulation of myeloid cell differentiation|neuron development|neuron differentiation|positive regulation of chemokine secretion|leukocyte differentiation|axon guidance|regulation of myeloid leukocyte differentiation|skeletal muscle organ development|central nervous system neuron differentiation|cytokine-mediated signaling pathway|positive regulation of protein modification process|actin cytoskeleton reorganization|mammary gland duct morphogenesis|regulation of MAPK cascade|regulation of actin cytoskeleton reorganization|ATP binding|regulation of protein secretion|adenyl nucleotide binding|phosphorylation|ERK1 and ERK2 cascade|axon development|protein phosphatase binding|inositol lipid-mediated signaling|chemokine secretion|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|bone resorption|cell-cell junction maintenance|positive regulation of myeloid leukocyte differentiation|positive regulation of MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|protein kinase activity|forebrain neuron differentiation|myeloid cell differentiation|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|mammary gland epithelium development|neuron projection morphogenesis|mammary gland morphogenesis|regulation of kinase activity|glycerophospholipid metabolic process|apoptotic process|positive regulation of kinase activity|macrophage colony-stimulating factor signaling pathway|cellular response to macrophage colony-stimulating factor stimulus|JAK-STAT cascade|myeloid leukocyte differentiation|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|phosphatidylinositol metabolic process|axonogenesis|positive regulation of osteoclast differentiation|protein phosphorylation|generation of neurons|skeletal muscle tissue development|regulation of JAK-STAT cascade|regulation of phosphorylation|macrophage colony-stimulating factor receptor activity|protein tyrosine kinase activity|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of JAK-STAT cascade|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|regulation of osteoclast differentiation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|macrophage differentiation|monocyte differentiation|protein autophosphorylation|positive regulation of protein serine/threonine kinase activity|tyrosine phosphorylation of STAT protein|osteoclast differentiation|positive regulation of tyrosine phosphorylation of STAT protein|regulation of protein serine/threonine kinase activity|positive regulation of protein tyrosine kinase activity|peptidyl-tyrosine phosphorylation|regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|tyrosine phosphorylation of Stat3 protein K05090 macrophage colony-stimulating factor 1 receptor[2.7.10.1] hsa05200|hsa04151|hsa04060|hsa04144|hsa04014|hsa04015|hsa05202|hsa04380|hsa04640 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human) 5:150053291-150113372 133 118 177 50 45 66 1.411340319273 1.1379990467042 1.69343156853082 0.475384697557402 0.391800320381957 0.656379137253617 1.41425697816934 0.507854718397659 1.4775565389985 2.65423308343399e-07 3.73067205615999e-06 UP ENSG00000143867 OSR1 odd-skipped related transciption factor 1 [Source:HGNC Symbol;Acc:HGNC:8111] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0045137|GO:0008284|GO:0042127|GO:0045595|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0035295|GO:1901360|GO:0001568|GO:0010941|GO:0032835|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0072028|GO:0034641|GO:0031325|GO:0046483|GO:0070169|GO:0043231|GO:0048608|GO:0072111|GO:0043169|GO:0007389|GO:0072189|GO:0007423|GO:0009887|GO:0048729|GO:0048598|GO:0072006|GO:0048568|GO:0007548|GO:0050673|GO:0009890|GO:0060548|GO:0006139|GO:0008406|GO:0045778|GO:0035148|GO:0030278|GO:0001503|GO:0008219|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0040019|GO:0031323|GO:0060021|GO:0072089|GO:0050679|GO:0030501|GO:0048705|GO:0010468|GO:0034645|GO:0051216|GO:0072143|GO:0072170|GO:0046872|GO:0042733|GO:0002009|GO:0033993|GO:0001944|GO:0072047|GO:0072164|GO:0061458|GO:0072358|GO:0061005|GO:0001655|GO:0010629|GO:0043583|GO:0007498|GO:0048793|GO:0072210|GO:0043069|GO:0051252|GO:0010463|GO:0031214|GO:0009790|GO:0072203|GO:0001656|GO:0010628|GO:0042474|GO:0072175|GO:0030856|GO:0060537|GO:0007369|GO:0072190|GO:0072001|GO:0072176|GO:0003002|GO:0060485|GO:0016331|GO:0072012|GO:0050678|GO:0072141|GO:0061326|GO:0060993|GO:0012501|GO:0060429|GO:0032526|GO:0072073|GO:0042476|GO:0007379|GO:0035108|GO:0072161|GO:0010467|GO:0048562|GO:0060562|GO:0072224|GO:0071310|GO:0031328|GO:2000543|GO:0010470|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0001823|GO:0060173|GO:0016070|GO:0072359|GO:0010557|GO:0030857|GO:0005634|GO:0030282|GO:0036023|GO:0043067|GO:0045995|GO:0030500|GO:0072234|GO:0048706|GO:0045893|GO:0048863|GO:0072208|GO:2000696|GO:0072239|GO:0009792|GO:0048389|GO:0072202|GO:0001657|GO:0072178|GO:0030855|GO:0045892|GO:0002062|GO:0032774|GO:2001141|GO:0001838|GO:0072078|GO:0072163|GO:1902679|GO:0072177|GO:0042471|GO:0061333|GO:0072162|GO:2001012|GO:0072168|GO:0072075|GO:0072166|GO:0072080|GO:0042981|GO:0009952|GO:0035136|GO:0072169|GO:0072160|GO:0043066|GO:0048745|GO:0048704|GO:0048762|GO:0090094|GO:0072183|GO:0072184|GO:0071300|GO:0009954|GO:0072207|GO:0072268|GO:0035137|GO:0071396|GO:0030326|GO:0072259|GO:0006351|GO:0035282|GO:0006915|GO:0006355|GO:0035115|GO:0035116|GO:0045944|GO:0006366|GO:0072133|GO:1903507|GO:0006357|GO:1903506|GO:0072498|GO:0060272|GO:0072180|GO:0072182|GO:0043009|GO:0000122|GO:0072172|GO:0072079 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|development of primary sexual characteristics|positive regulation of cell proliferation|regulation of cell proliferation|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|tube development|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|glomerulus development|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|nephron morphogenesis|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of biomineral tissue development|intracellular membrane-bounded organelle|reproductive structure development|cell proliferation involved in kidney development|cation binding|pattern specification process|ureter development|sensory organ development|organ morphogenesis|tissue morphogenesis|embryonic morphogenesis|nephron development|embryonic organ development|sex differentiation|epithelial cell proliferation|negative regulation of biosynthetic process|negative regulation of cell death|nucleobase-containing compound metabolic process|gonad development|positive regulation of ossification|tube formation|regulation of ossification|ossification|cell death|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|positive regulation of embryonic development|regulation of cellular metabolic process|palate development|stem cell proliferation|positive regulation of epithelial cell proliferation|positive regulation of bone mineralization|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|mesangial cell development|metanephric tubule development|metal ion binding|embryonic digit morphogenesis|morphogenesis of an epithelium|response to lipid|vasculature development|proximal/distal pattern formation involved in nephron development|mesonephric tubule development|reproductive system development|cardiovascular system development|cell differentiation involved in kidney development|urogenital system development|negative regulation of gene expression|ear development|mesoderm development|pronephros development|metanephric nephron development|negative regulation of programmed cell death|regulation of RNA metabolic process|mesenchymal cell proliferation|biomineral tissue development|embryo development|cell proliferation involved in metanephros development|metanephros development|positive regulation of gene expression|middle ear morphogenesis|epithelial tube formation|regulation of epithelial cell differentiation|muscle tissue development|gastrulation|ureter urothelium development|renal system development|nephric duct development|regionalization|mesenchyme development|morphogenesis of embryonic epithelium|glomerulus vasculature development|regulation of epithelial cell proliferation|renal interstitial fibroblast development|renal tubule development|kidney morphogenesis|programmed cell death|epithelium development|response to retinoic acid|kidney epithelium development|odontogenesis|segment specification|limb morphogenesis|mesenchymal cell differentiation involved in kidney development|gene expression|embryonic organ morphogenesis|epithelial tube morphogenesis|metanephric glomerulus development|cellular response to organic substance|positive regulation of cellular biosynthetic process|positive regulation of gastrulation|regulation of gastrulation|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|mesonephros development|limb development|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|negative regulation of epithelial cell differentiation|nucleus|bone mineralization|embryonic skeletal limb joint morphogenesis|regulation of programmed cell death|regulation of embryonic development|regulation of bone mineralization|metanephric nephron tubule development|embryonic skeletal system development|positive regulation of transcription, DNA-templated|stem cell differentiation|metanephric smooth muscle tissue development|regulation of epithelial cell differentiation involved in kidney development|metanephric glomerulus vasculature development|embryo development ending in birth or egg hatching|intermediate mesoderm development|cell differentiation involved in metanephros development|ureteric bud development|nephric duct morphogenesis|epithelial cell differentiation|negative regulation of transcription, DNA-templated|chondrocyte differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|embryonic epithelial tube formation|nephron tubule morphogenesis|mesonephric epithelium development|negative regulation of RNA biosynthetic process|mesonephric duct development|ear morphogenesis|renal tubule morphogenesis|metanephric mesenchymal cell differentiation|mesenchymal cell differentiation involved in renal system development|specification of anterior mesonephric tubule identity|metanephric mesenchyme development|posterior mesonephric tubule development|nephron tubule development|regulation of apoptotic process|anterior/posterior pattern specification|forelimb morphogenesis|specification of posterior mesonephric tubule identity|nephron tubule epithelial cell differentiation|negative regulation of apoptotic process|smooth muscle tissue development|embryonic skeletal system morphogenesis|mesenchymal cell differentiation|metanephric cap mesenchymal cell proliferation involved in metanephros development|negative regulation of nephron tubule epithelial cell differentiation|renal vesicle progenitor cell differentiation|cellular response to retinoic acid|proximal/distal pattern formation|metanephric epithelium development|pattern specification involved in metanephros development|hindlimb morphogenesis|cellular response to lipid|embryonic limb morphogenesis|metanephric interstitial fibroblast development|transcription, DNA-templated|segmentation|apoptotic process|regulation of transcription, DNA-templated|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|metanephric mesenchyme morphogenesis|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|embryonic skeletal joint development|embryonic skeletal joint morphogenesis|mesonephric duct morphogenesis|regulation of nephron tubule epithelial cell differentiation|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|mesonephric tubule formation|nephron tubule formation - - - - 2:19351485-19358653 5 8 5 28 40 32 0.0528859068802742 0.0768986866974515 0.047675969767748 0.265340872425139 0.34712037087952 0.317198851538365 0.0591535211151579 0.309886698281008 -2.38920487664826 2.6793848255284e-07 3.76425198029763e-06 DOWN ENSG00000174371 EXO1 exonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3511] GO:0032502|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0044877|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0002250|GO:0007049|GO:0006281|GO:0006959|GO:0016445|GO:0006725|GO:1901360|GO:0045190|GO:0007275|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0002377|GO:0001775|GO:0002312|GO:0002263|GO:0003682|GO:0006139|GO:0046649|GO:0002366|GO:0002566|GO:0002443|GO:0003677|GO:0042113|GO:0046872|GO:0000725|GO:0016446|GO:0016447|GO:0006302|GO:0031981|GO:0004518|GO:0006298|GO:0005654|GO:0006259|GO:0002460|GO:0002381|GO:0016070|GO:0002455|GO:0005634|GO:0006974|GO:0000724|GO:0090501|GO:0004536|GO:0004527|GO:0006310|GO:0004519|GO:0004540|GO:0090305|GO:0019724|GO:0002204|GO:0004520|GO:0016064|GO:0045003|GO:0016444|GO:0090502|GO:0004521|GO:0008409|GO:0035312|GO:0048256|GO:0016891|GO:0008297|GO:0051908|GO:0008309|GO:0045145|GO:0004523 developmental process|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|immune response|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|immune system development|protein binding|anatomical structure development|adaptive immune response|cell cycle|DNA repair|humoral immune response|somatic diversification of immunoglobulins|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|isotype switching|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|immunoglobulin production|cell activation|B cell activation involved in immune response|cell activation involved in immune response|chromatin binding|nucleobase-containing compound metabolic process|lymphocyte activation|leukocyte activation involved in immune response|somatic diversification of immune receptors via somatic mutation|leukocyte mediated immunity|DNA binding|B cell activation|metal ion binding|recombinational repair|somatic hypermutation of immunoglobulin genes|somatic recombination of immunoglobulin gene segments|double-strand break repair|nuclear lumen|nuclease activity|mismatch repair|nucleoplasm|DNA metabolic process|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|immunoglobulin production involved in immunoglobulin mediated immune response|RNA metabolic process|humoral immune response mediated by circulating immunoglobulin|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|RNA phosphodiester bond hydrolysis|deoxyribonuclease activity|exonuclease activity|DNA recombination|endonuclease activity|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|B cell mediated immunity|somatic recombination of immunoglobulin genes involved in immune response|endodeoxyribonuclease activity|immunoglobulin mediated immune response|double-strand break repair via synthesis-dependent strand annealing|somatic cell DNA recombination|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|5'-3' exonuclease activity|5'-3' exodeoxyribonuclease activity|flap endonuclease activity|endoribonuclease activity, producing 5'-phosphomonoesters|single-stranded DNA exodeoxyribonuclease activity|double-stranded DNA 5'-3' exodeoxyribonuclease activity|double-stranded DNA exodeoxyribonuclease activity|single-stranded DNA 5'-3' exodeoxyribonuclease activity|RNA-DNA hybrid ribonuclease activity K10746 exonuclease 1 [EC:3.1.-.-][-] hsa03430 Mismatch repair - Homo sapiens (human) 1:241847967-241895148 1561 1671 1743 943 964 581 16.7633561538827 16.308521921575 16.8760044142833 9.07334511683099 8.49381705027471 5.84740909674084 16.649294163247 7.80485708794885 1.0930168955441 2.7382011532697e-07 3.84145945628354e-06 UP ENSG00000259494 MRPL46 mitochondrial ribosomal protein L46 [Source:HGNC Symbol;Acc:HGNC:1192] GO:0032991|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0003735|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0031090|GO:0019866|GO:0034641|GO:0005761|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0031966|GO:0044249|GO:0019538|GO:0006996|GO:0005740|GO:0034645|GO:0006518|GO:0007005|GO:0005840|GO:0005743|GO:0031981|GO:0005654|GO:0005759|GO:0005739|GO:0015934|GO:0070124|GO:0043603|GO:0044267|GO:0010467|GO:0005762|GO:0009059|GO:0005634|GO:0032543|GO:0043241|GO:0043043|GO:0070125|GO:0006412|GO:0070126|GO:0006414|GO:0043624|GO:0006415 macromolecular complex|structural molecule activity|cell|membrane|cellular process|metabolic process|cell junction|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|structural constituent of ribosome|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|organelle membrane|organelle inner membrane|cellular nitrogen compound metabolic process|mitochondrial ribosome|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|cellular biosynthetic process|protein metabolic process|organelle organization|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|mitochondrion organization|ribosome|mitochondrial inner membrane|nuclear lumen|nucleoplasm|mitochondrial matrix|mitochondrion|large ribosomal subunit|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|mitochondrial large ribosomal subunit|macromolecule biosynthetic process|nucleus|mitochondrial translation|protein complex disassembly|peptide biosynthetic process|mitochondrial translational elongation|translation|mitochondrial translational termination|translational elongation|cellular protein complex disassembly|translational termination - - - - 15:88459476-88467419 115 163 172 443 447 320 0.923875545060525 1.19010342572927 1.24583281658373 3.18873231013664 2.94639924018869 2.40932630975412 1.11993726245784 2.84815262002648 -1.34660853958449 2.75345725023261e-07 3.85923534030255e-06 DOWN ENSG00000131400 NAPSA napsin A aspartic peptidase [Source:HGNC Symbol;Acc:HGNC:13395] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0031982|GO:0030141|GO:0043231|GO:0008233|GO:0005737|GO:0042592|GO:0048871|GO:0070062|GO:0019538|GO:0005768|GO:0030163|GO:0031410|GO:0048878|GO:0001894|GO:0005773|GO:0016023|GO:0005770|GO:0042599|GO:0006508|GO:0031988|GO:0044267|GO:0031904|GO:0005771|GO:0000323|GO:0097208|GO:0033619|GO:0070001|GO:0048875|GO:0004175|GO:0097486|GO:0005764|GO:0043129|GO:0004190 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|extracellular space|intracellular|protein binding|endomembrane system|vesicle|secretory granule|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|homeostatic process|multicellular organismal homeostasis|extracellular exosome|protein metabolic process|endosome|protein catabolic process|cytoplasmic vesicle|chemical homeostasis|tissue homeostasis|vacuole|cytoplasmic, membrane-bounded vesicle|late endosome|lamellar body|proteolysis|membrane-bounded vesicle|cellular protein metabolic process|endosome lumen|multivesicular body|lytic vacuole|alveolar lamellar body|membrane protein proteolysis|aspartic-type peptidase activity|chemical homeostasis within a tissue|endopeptidase activity|multivesicular body lumen|lysosome|surfactant homeostasis|aspartic-type endopeptidase activity K08565 napsin-A [EC:3.4.23.-][-] hsa04142 Lysosome - Homo sapiens (human) 19:50358477-50365830 54 42 65 20 9 14 0.52005598121819 0.367606084046415 0.564393908407865 0.172573578478509 0.0711145762918229 0.126363712564855 0.484018657890823 0.123350622445062 1.97229766569616 2.77417198794172e-07 3.88644441708175e-06 UP ENSG00000170088 TMEM192 transmembrane protein 192 [Source:HGNC Symbol;Acc:HGNC:26775] GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0042802|GO:0031982|GO:0043231|GO:0005774|GO:0005737|GO:0046983|GO:0070062|GO:0016021|GO:0005768|GO:0005773|GO:0005770|GO:0031981|GO:0048471|GO:0005654|GO:0005634|GO:0042803|GO:0000323|GO:0005765|GO:0005764 cell|membrane|extracellular region|binding|extracellular vesicle|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|identical protein binding|vesicle|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|protein dimerization activity|extracellular exosome|integral component of membrane|endosome|vacuole|late endosome|nuclear lumen|perinuclear region of cytoplasm|nucleoplasm|nucleus|protein homodimerization activity|lytic vacuole|lysosomal membrane|lysosome - - - - 4:165070608-165208549 1339 1583 1107 698 742 551 8.0774899488909 8.67874392925604 6.02084836948952 3.77267272733188 3.67254955107717 3.11513127169527 7.59236074921215 3.52011785003477 1.1089248136366 2.78993222817252e-07 3.90485873135782e-06 UP ENSG00000197208 SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 [Source:HGNC Symbol;Acc:HGNC:10968] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0045177|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0044255|GO:0006810|GO:0006082|GO:0016324|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0005887|GO:0043231|GO:0005737|GO:0022891|GO:0019904|GO:0031226|GO:0055085|GO:0006629|GO:0000166|GO:0016021|GO:0050878|GO:0046486|GO:0035639|GO:0007589|GO:0015697|GO:0001883|GO:0030165|GO:0006577|GO:1903825|GO:0006811|GO:0032549|GO:0015075|GO:0006638|GO:0009437|GO:0005739|GO:0015226|GO:0046903|GO:0017076|GO:0034220|GO:0098655|GO:0006820|GO:0015711|GO:0098656|GO:0008513|GO:0015293|GO:0005524|GO:0015297|GO:0015879|GO:0008509|GO:0006812|GO:0015696|GO:0030554|GO:0046942|GO:0046943|GO:0019752|GO:0006639|GO:0015695|GO:0008324|GO:0015718|GO:1902603|GO:0072488|GO:0015101|GO:0022890|GO:0015491|GO:0032787|GO:0030001|GO:0008514|GO:0015672|GO:0006641|GO:0008028|GO:0006814|GO:0015651|GO:0015077|GO:0008519 transporter activity|cell|membrane|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|apical part of cell|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|cellular lipid metabolic process|transport|organic acid metabolic process|apical plasma membrane|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|substrate-specific transmembrane transporter activity|protein domain specific binding|intrinsic component of plasma membrane|transmembrane transport|lipid metabolic process|nucleotide binding|integral component of membrane|regulation of body fluid levels|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|body fluid secretion|quaternary ammonium group transport|purine nucleoside binding|PDZ domain binding|amino-acid betaine metabolic process|organic acid transmembrane transport|ion transport|ribonucleoside binding|ion transmembrane transporter activity|neutral lipid metabolic process|carnitine metabolic process|mitochondrion|carnitine transmembrane transporter activity|secretion|purine nucleotide binding|ion transmembrane transport|cation transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|secondary active organic cation transmembrane transporter activity|symporter activity|ATP binding|antiporter activity|carnitine transport|anion transmembrane transporter activity|cation transport|ammonium transport|adenyl nucleotide binding|carboxylic acid transport|carboxylic acid transmembrane transporter activity|carboxylic acid metabolic process|acylglycerol metabolic process|organic cation transport|cation transmembrane transporter activity|monocarboxylic acid transport|carnitine transmembrane transport|ammonium transmembrane transport|organic cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|cation:cation antiporter activity|monocarboxylic acid metabolic process|metal ion transport|organic anion transmembrane transporter activity|monovalent inorganic cation transport|triglyceride metabolic process|monocarboxylic acid transmembrane transporter activity|sodium ion transport|quaternary ammonium group transmembrane transporter activity|monovalent inorganic cation transmembrane transporter activity|ammonium transmembrane transporter activity K08202 MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5[-] hsa05231 Choline metabolism in cancer - Homo sapiens (human) 5:132294443-132344206 9 13 20 59 56 55 0.227613584915243 0.298807776791481 0.456046135121298 1.3369231771488 1.16201138089 1.30358923713869 0.327489165609341 1.26750793172583 -1.95247569167798 2.80097676459183e-07 3.91847986551661e-06 DOWN ENSG00000230133 FLJ33581 uncharacterized LOC400839 [Source:EntrezGene;Acc:400839] - - - - - - 20:24199767-24224588 4 7 5 31 31 29 0.119080072303308 0.189411422227002 0.13419902601292 0.826898254837461 0.757240941741916 0.809132224833767 0.147563506847743 0.797757140471048 -2.43461363645771 2.81057272296992e-07 3.93006267314023e-06 DOWN ENSG00000139629 GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:4128] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0048471|GO:0070085|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0008376|GO:0006464|GO:0016266|GO:0004653|GO:0043687 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|perinuclear region of cytoplasm|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|acetylgalactosaminyltransferase activity|cellular protein modification process|O-glycan processing|polypeptide N-acetylgalactosaminyltransferase activity|post-translational protein modification K00710 polypeptide N-acetylgalactosaminyltransferase[2.4.1.41] hsa01100|hsa00512 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human) 12:51351247-51392867 407 445 588 956 1079 1236 2.02346910805142 2.01067471533903 2.63568269249097 4.25850740155669 4.40140540738419 5.75902985187084 2.22327550529381 4.80631422027057 -1.11224423372305 2.8523093387174e-07 3.98655632013433e-06 DOWN ENSG00000152413 HOMER1 homer scaffolding protein 1 [Source:HGNC Symbol;Acc:HGNC:17512] GO:0032502|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0042995|GO:0050794|GO:0060076|GO:0043229|GO:0051050|GO:0045177|GO:0023051|GO:0044708|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0030017|GO:0035591|GO:0030018|GO:0009888|GO:0048468|GO:0030534|GO:0044325|GO:0006810|GO:0007275|GO:0048513|GO:0005102|GO:0043270|GO:0045211|GO:0061061|GO:0010243|GO:0005737|GO:0003012|GO:0007267|GO:0042592|GO:0043005|GO:0009966|GO:0097481|GO:0014069|GO:0031674|GO:0048871|GO:0010646|GO:0007154|GO:0055085|GO:0007165|GO:0043034|GO:0048869|GO:0010035|GO:0009967|GO:0010033|GO:0007186|GO:0006936|GO:0007166|GO:0048148|GO:0030424|GO:0042692|GO:0048878|GO:0001894|GO:0010038|GO:0060537|GO:0006811|GO:0043279|GO:0043292|GO:0034765|GO:0001664|GO:0055001|GO:0043269|GO:0014070|GO:0060359|GO:0030154|GO:0007517|GO:0051928|GO:0050881|GO:0042220|GO:0035254|GO:0022898|GO:0034220|GO:0006941|GO:0055002|GO:0060538|GO:0098655|GO:0007216|GO:0007200|GO:0030016|GO:0007215|GO:0003009|GO:0006812|GO:0051592|GO:0035256|GO:0032412|GO:0048875|GO:0051146|GO:0014706|GO:0090279|GO:0007519|GO:0048747|GO:0007206|GO:0014902|GO:0030001|GO:0014904|GO:0051924|GO:2001257|GO:0007268|GO:2001256|GO:0048741|GO:0006816|GO:0070509|GO:0002115 developmental process|synapse|behavior|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|binding, bridging|cellular response to stimulus|cell projection|regulation of cellular process|excitatory synapse|intracellular organelle|positive regulation of transport|apical part of cell|regulation of signaling|single-organism behavior|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|synaptic membrane|sarcomere|signaling adaptor activity|Z disc|tissue development|cell development|adult behavior|ion channel binding|transport|multicellular organism development|animal organ development|receptor binding|positive regulation of ion transport|postsynaptic membrane|muscle structure development|response to organonitrogen compound|cytoplasm|muscle system process|cell-cell signaling|homeostatic process|neuron projection|regulation of signal transduction|neuronal postsynaptic density|postsynaptic density|I band|multicellular organismal homeostasis|regulation of cell communication|cell communication|transmembrane transport|signal transduction|costamere|cellular developmental process|response to inorganic substance|positive regulation of signal transduction|response to organic substance|G-protein coupled receptor signaling pathway|muscle contraction|cell surface receptor signaling pathway|behavioral response to cocaine|axon|muscle cell differentiation|chemical homeostasis|tissue homeostasis|response to metal ion|muscle tissue development|ion transport|response to alkaloid|contractile fiber|regulation of ion transmembrane transport|G-protein coupled receptor binding|muscle cell development|regulation of ion transport|response to organic cyclic compound|response to ammonium ion|cell differentiation|muscle organ development|positive regulation of calcium ion transport|musculoskeletal movement|response to cocaine|glutamate receptor binding|regulation of transmembrane transporter activity|ion transmembrane transport|striated muscle contraction|striated muscle cell development|skeletal muscle organ development|cation transmembrane transport|G-protein coupled glutamate receptor signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|myofibril|glutamate receptor signaling pathway|skeletal muscle contraction|cation transport|response to calcium ion|G-protein coupled glutamate receptor binding|regulation of ion transmembrane transporter activity|chemical homeostasis within a tissue|striated muscle cell differentiation|striated muscle tissue development|regulation of calcium ion import|skeletal muscle tissue development|muscle fiber development|phospholipase C-activating G-protein coupled glutamate receptor signaling pathway|myotube differentiation|metal ion transport|myotube cell development|regulation of calcium ion transport|regulation of cation channel activity|synaptic transmission|regulation of store-operated calcium entry|skeletal muscle fiber development|calcium ion transport|calcium ion import|store-operated calcium entry K15010 homer[-] hsa04068|hsa04724 FoxO signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human) 5:79372636-79514217 185 169 213 435 558 434 1.91097234585646 1.58653394801703 1.98369713191507 4.02595519420246 4.72915796538781 4.20146171848717 1.82706780859619 4.31885829269248 -1.24111980244118 2.85996061807935e-07 3.99537970482644e-06 DOWN ENSG00000204248 COL11A2 collagen, type XI, alpha 2 [Source:HGNC Symbol;Acc:HGNC:2187] GO:0032502|GO:0031012|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0060090|GO:0005201|GO:0043229|GO:0005578|GO:0071704|GO:0009056|GO:0043167|GO:0009653|GO:0016043|GO:0005583|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0009888|GO:0007275|GO:0048513|GO:0050877|GO:0060023|GO:0043062|GO:0043231|GO:0043169|GO:0005737|GO:0030529|GO:0009887|GO:0042592|GO:0005592|GO:0030674|GO:0048871|GO:0044236|GO:0030020|GO:0005783|GO:0048869|GO:0005581|GO:0060021|GO:0048705|GO:0030574|GO:0044259|GO:0051216|GO:0046872|GO:0022617|GO:0001894|GO:0005840|GO:0007600|GO:0005788|GO:0030198|GO:0030154|GO:0001501|GO:0061448|GO:0050954|GO:0002062|GO:0030199|GO:0032963|GO:0007605 developmental process|extracellular matrix|macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|binding|binding, bridging|extracellular matrix structural constituent|intracellular organelle|proteinaceous extracellular matrix|organic substance metabolic process|catabolic process|ion binding|anatomical structure morphogenesis|cellular component organization|fibrillar collagen trimer|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|tissue development|multicellular organism development|animal organ development|neurological system process|soft palate development|extracellular structure organization|intracellular membrane-bounded organelle|cation binding|cytoplasm|intracellular ribonucleoprotein complex|organ morphogenesis|homeostatic process|collagen type XI trimer|protein binding, bridging|multicellular organismal homeostasis|multicellular organism metabolic process|extracellular matrix structural constituent conferring tensile strength|endoplasmic reticulum|cellular developmental process|collagen trimer|palate development|skeletal system morphogenesis|collagen catabolic process|multicellular organismal macromolecule metabolic process|cartilage development|metal ion binding|extracellular matrix disassembly|tissue homeostasis|ribosome|sensory perception|endoplasmic reticulum lumen|extracellular matrix organization|cell differentiation|skeletal system development|connective tissue development|sensory perception of mechanical stimulus|chondrocyte differentiation|collagen fibril organization|collagen metabolic process|sensory perception of sound - - - - 6:33162681-33192499 106 66 70 15 22 30 0.739821310039466 0.418644493065475 0.440486447268127 0.0938017493829796 0.125985980731658 0.19623625341225 0.532984083457689 0.138674661175629 1.94238824979634 2.86457490076495e-07 3.99995412008591e-06 UP ENSG00000132329 RAMP1 receptor (G protein-coupled) activity modifying protein 1 [Source:HGNC Symbol;Acc:HGNC:9843] GO:0032502|GO:0032991|GO:0004871|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0006807|GO:0071704|GO:0009986|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0006486|GO:0044262|GO:0006725|GO:0008565|GO:0006810|GO:0031623|GO:1901360|GO:0001568|GO:0007275|GO:0005102|GO:0034641|GO:0044281|GO:0019637|GO:0031325|GO:0046483|GO:0005887|GO:0004888|GO:0043235|GO:0005975|GO:0009966|GO:0045184|GO:0010646|GO:0006139|GO:0031226|GO:0001525|GO:0055086|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0051649|GO:0015026|GO:0016021|GO:0044249|GO:0019538|GO:0031323|GO:0010256|GO:0016192|GO:0032268|GO:0006109|GO:0007186|GO:0034645|GO:0001944|GO:0043412|GO:0072358|GO:1903020|GO:0019693|GO:0008277|GO:0060050|GO:0015031|GO:0007009|GO:0009100|GO:0036211|GO:0046907|GO:0006811|GO:0072657|GO:0051247|GO:0070085|GO:0001664|GO:0034613|GO:0032270|GO:0006796|GO:1901137|GO:0044267|GO:0051174|GO:0031328|GO:0051246|GO:0009059|GO:0008528|GO:0072359|GO:0004930|GO:0010557|GO:0060049|GO:0043112|GO:0009101|GO:0043413|GO:0010560|GO:0031401|GO:0009259|GO:0009117|GO:0072659|GO:0046390|GO:0006812|GO:0031716|GO:0006886|GO:0006163|GO:0010559|GO:0006897|GO:0006464|GO:0009165|GO:1990778|GO:0006164|GO:0030801|GO:0006898|GO:0009187|GO:0030001|GO:0030802|GO:0009190|GO:0004948|GO:0046058|GO:0030819|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030816|GO:0006171|GO:0006816 developmental process|macromolecular complex|signal transducer activity|transporter activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cell surface|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|protein glycosylation|cellular carbohydrate metabolic process|cellular aromatic compound metabolic process|protein transporter activity|transport|receptor internalization|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|integral component of plasma membrane|transmembrane signaling receptor activity|receptor complex|carbohydrate metabolic process|regulation of signal transduction|establishment of protein localization|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|angiogenesis|nucleobase-containing small molecule metabolic process|protein localization|cell communication|membrane organization|signal transduction|establishment of localization in cell|coreceptor activity|integral component of membrane|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|endomembrane system organization|vesicle-mediated transport|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|G-protein coupled receptor signaling pathway|cellular macromolecule biosynthetic process|vasculature development|macromolecule modification|cardiovascular system development|positive regulation of glycoprotein metabolic process|ribose phosphate metabolic process|regulation of G-protein coupled receptor protein signaling pathway|positive regulation of protein glycosylation|protein transport|plasma membrane organization|glycoprotein metabolic process|protein modification process|intracellular transport|ion transport|protein localization to membrane|positive regulation of protein metabolic process|glycosylation|G-protein coupled receptor binding|cellular protein localization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|G-protein coupled peptide receptor activity|circulatory system development|G-protein coupled receptor activity|positive regulation of macromolecule biosynthetic process|regulation of protein glycosylation|receptor metabolic process|glycoprotein biosynthetic process|macromolecule glycosylation|positive regulation of glycoprotein biosynthetic process|positive regulation of protein modification process|ribonucleotide metabolic process|nucleotide metabolic process|protein localization to plasma membrane|ribose phosphate biosynthetic process|cation transport|calcitonin receptor binding|intracellular protein transport|purine nucleotide metabolic process|regulation of glycoprotein biosynthetic process|endocytosis|cellular protein modification process|nucleotide biosynthetic process|protein localization to cell periphery|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|receptor-mediated endocytosis|cyclic nucleotide metabolic process|metal ion transport|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|calcitonin receptor activity|cAMP metabolic process|positive regulation of cAMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|positive regulation of cAMP metabolic process|cAMP biosynthetic process|calcium ion transport K08447 receptor activity modifying protein 1[-] hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) 2:237858893-237912114 255 255 342 621 683 685 8.01327712734043 7.2826710150247 9.68972003378326 17.4847601268314 17.6099941197363 20.1738993516301 8.32855605871613 18.4228845327326 -1.14536066774681 2.87588108817936e-07 4.01386414242668e-06 DOWN ENSG00000041982 TNC tenascin C [Source:HGNC Symbol;Acc:HGNC:5318] GO:0032502|GO:0031012|GO:0040007|GO:0000003|GO:0023052|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0005604|GO:0051716|GO:0030055|GO:0048523|GO:0008283|GO:0050794|GO:0005578|GO:0006950|GO:0044702|GO:0071704|GO:0009628|GO:0003006|GO:0009653|GO:0016043|GO:0007155|GO:0009605|GO:0009893|GO:0005615|GO:0048589|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0035239|GO:0009888|GO:0048468|GO:0035295|GO:0009612|GO:0009991|GO:0007275|GO:0030324|GO:0048513|GO:0005924|GO:0043062|GO:0030155|GO:0005912|GO:0045545|GO:0033554|GO:0060740|GO:0048608|GO:0001763|GO:0007267|GO:0031668|GO:0009611|GO:0060512|GO:0009887|GO:0048729|GO:0030323|GO:0007162|GO:0005614|GO:0007154|GO:0050808|GO:0001503|GO:0009725|GO:0060739|GO:0030030|GO:0048869|GO:0030850|GO:0010033|GO:0048732|GO:0071774|GO:0007584|GO:0060560|GO:0060425|GO:0031175|GO:0010468|GO:0002009|GO:0033993|GO:0031102|GO:0061458|GO:0007528|GO:0001655|GO:0048678|GO:0060541|GO:0048754|GO:0061138|GO:0022612|GO:0010628|GO:0031670|GO:0042060|GO:0033273|GO:0001649|GO:0070848|GO:0060638|GO:0070542|GO:0014070|GO:0060429|GO:0032526|GO:0042476|GO:0010467|GO:0003401|GO:0007399|GO:0060562|GO:0071310|GO:0030198|GO:0030154|GO:0031669|GO:0031667|GO:0032870|GO:0097305|GO:0005925|GO:0048666|GO:0030182|GO:0060602|GO:0071398|GO:0033280|GO:0071407|GO:0061564|GO:0045471|GO:0071295|GO:0042475|GO:0060441|GO:0071300|GO:0022008|GO:0031103|GO:0071379|GO:0071396|GO:0048699|GO:0060447|GO:0071799|GO:0014012|GO:0071305 developmental process|extracellular matrix|growth|reproduction|signaling|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|basement membrane|cellular response to stimulus|cell-substrate junction|negative regulation of cellular process|cell proliferation|regulation of cellular process|proteinaceous extracellular matrix|response to stress|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|cell adhesion|response to external stimulus|positive regulation of metabolic process|extracellular space|developmental growth|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|tube morphogenesis|tissue development|cell development|tube development|response to mechanical stimulus|response to extracellular stimulus|multicellular organism development|lung development|animal organ development|cell-substrate adherens junction|extracellular structure organization|regulation of cell adhesion|adherens junction|syndecan binding|cellular response to stress|prostate gland epithelium morphogenesis|reproductive structure development|morphogenesis of a branching structure|cell-cell signaling|cellular response to extracellular stimulus|response to wounding|prostate gland morphogenesis|organ morphogenesis|tissue morphogenesis|respiratory tube development|negative regulation of cell adhesion|interstitial matrix|cell communication|synapse organization|ossification|response to hormone|mesenchymal-epithelial cell signaling involved in prostate gland development|cell projection organization|cellular developmental process|prostate gland development|response to organic substance|gland development|response to fibroblast growth factor|response to nutrient|developmental growth involved in morphogenesis|lung morphogenesis|neuron projection development|regulation of gene expression|morphogenesis of an epithelium|response to lipid|neuron projection regeneration|reproductive system development|neuromuscular junction development|urogenital system development|response to axon injury|respiratory system development|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|gland morphogenesis|positive regulation of gene expression|cellular response to nutrient|wound healing|response to vitamin|osteoblast differentiation|response to growth factor|mesenchymal-epithelial cell signaling|response to fatty acid|response to organic cyclic compound|epithelium development|response to retinoic acid|odontogenesis|gene expression|axis elongation|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|extracellular matrix organization|cell differentiation|cellular response to nutrient levels|response to nutrient levels|cellular response to hormone stimulus|response to alcohol|focal adhesion|neuron development|neuron differentiation|branch elongation of an epithelium|cellular response to fatty acid|response to vitamin D|cellular response to organic cyclic compound|axon development|response to ethanol|cellular response to vitamin|odontogenesis of dentin-containing tooth|epithelial tube branching involved in lung morphogenesis|cellular response to retinoic acid|neurogenesis|axon regeneration|cellular response to prostaglandin stimulus|cellular response to lipid|generation of neurons|bud outgrowth involved in lung branching|cellular response to prostaglandin D stimulus|peripheral nervous system axon regeneration|cellular response to vitamin D K06252 tenascin[-] hsa04151|hsa05206|hsa04510|hsa04512 PI3K-Akt signaling pathway - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 9:115019578-115118257 67 78 87 209 227 198 0.306835467489849 0.324641302742938 0.35922074665478 0.857580048326438 0.852949421821348 0.849812214815967 0.330232505629189 0.853447228321251 -1.36981981364397 2.88645994778763e-07 4.02674650846971e-06 DOWN ENSG00000254024 KB-1562D12.1 - - - - - - - 8:101461177-101492499 8 7 6 38 42 31 1.15248167736318 0.916581546255308 0.779365197515847 4.90510851496471 4.96458121030958 4.18562153505268 0.949476140378112 4.68510375344232 -2.30287734517955 2.95433143333805e-07 4.119505399854e-06 DOWN ENSG00000150867 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [Source:HGNC Symbol;Acc:HGNC:8997] GO:0032502|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0002520|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:1902117|GO:0044255|GO:0010506|GO:0048468|GO:1902115|GO:0051130|GO:0009991|GO:0007275|GO:0048513|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0031325|GO:0051128|GO:0033554|GO:0022607|GO:0043231|GO:0005737|GO:0010508|GO:0010646|GO:0007154|GO:0006629|GO:0060348|GO:0016236|GO:0000166|GO:0048869|GO:0044249|GO:0031323|GO:0006996|GO:0005829|GO:0008654|GO:0046486|GO:0035639|GO:0030097|GO:0001883|GO:2000785|GO:0005773|GO:0016239|GO:0032549|GO:0016241|GO:0016301|GO:0070925|GO:0006796|GO:0033043|GO:0008610|GO:0017076|GO:2000786|GO:0030154|GO:0001501|GO:0030258|GO:0000045|GO:0031667|GO:0016773|GO:0005634|GO:0006644|GO:0007033|GO:0010638|GO:0046474|GO:0044090|GO:0005524|GO:0035855|GO:0030554|GO:0016310|GO:0044088|GO:0005776|GO:0016307|GO:0002244|GO:0046834|GO:0030099|GO:0006650|GO:0016309|GO:0046854|GO:0046488|GO:0030219|GO:0016308|GO:0006661 developmental process|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|immune system development|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|positive regulation of organelle assembly|cellular lipid metabolic process|regulation of autophagy|cell development|regulation of organelle assembly|positive regulation of cellular component organization|response to extracellular stimulus|multicellular organism development|animal organ development|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|positive regulation of autophagy|regulation of cell communication|cell communication|lipid metabolic process|bone development|macroautophagy|nucleotide binding|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|hemopoiesis|purine nucleoside binding|regulation of autophagosome assembly|vacuole|positive regulation of macroautophagy|ribonucleoside binding|regulation of macroautophagy|kinase activity|organelle assembly|phosphate-containing compound metabolic process|regulation of organelle organization|lipid biosynthetic process|purine nucleotide binding|positive regulation of autophagosome assembly|cell differentiation|skeletal system development|lipid modification|autophagosome assembly|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|nucleus|phospholipid metabolic process|vacuole organization|positive regulation of organelle organization|glycerophospholipid biosynthetic process|positive regulation of vacuole organization|ATP binding|megakaryocyte development|adenyl nucleotide binding|phosphorylation|regulation of vacuole organization|autophagosome|phosphatidylinositol phosphate kinase activity|hematopoietic progenitor cell differentiation|lipid phosphorylation|myeloid cell differentiation|glycerophospholipid metabolic process|1-phosphatidylinositol-5-phosphate 4-kinase activity|phosphatidylinositol phosphorylation|phosphatidylinositol metabolic process|megakaryocyte differentiation|1-phosphatidylinositol-4-phosphate 5-kinase activity|phosphatidylinositol biosynthetic process K00920 1-phosphatidylinositol-5-phosphate 4-kinase[2.7.1.149] hsa04810|hsa04070|hsa00562 Regulation of actin cytoskeleton - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 10:22534849-22714555 232 317 552 890 1056 937 2.48162433621066 3.08167324719838 5.32353700668888 8.52971953330131 9.26785469761251 9.39325128961386 3.62894486336597 9.06360850684256 -1.32053540949688 2.9963308592964e-07 4.17611864955344e-06 DOWN ENSG00000236204 LINC01376 long intergenic non-protein coding RNA 1376 [Source:HGNC Symbol;Acc:HGNC:50637] - - - - - - 2:18986451-19346748 3 13 10 37 45 57 0.0637721812857404 0.251131415770965 0.191640781240125 0.704626012360221 0.784777925380447 1.13545105281933 0.168848126098943 0.874951663519999 -2.37347714963443 3.00503448830545e-07 4.18629489565426e-06 DOWN ENSG00000111237 VPS29 VPS29 retromer complex component [Source:HGNC Symbol;Acc:HGNC:14340] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0030906|GO:0043229|GO:0043167|GO:0051641|GO:0043227|GO:0030904|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0008565|GO:0006810|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0045184|GO:0008104|GO:0070062|GO:0051649|GO:0010008|GO:0005768|GO:0016192|GO:0005829|GO:0046872|GO:0005769|GO:0015031|GO:0046907|GO:0005770|GO:0034613|GO:0042147|GO:0016482|GO:0006886|GO:1990126|GO:0016197 macromolecular complex|transporter activity|cell|membrane|extracellular region|binding|extracellular vesicle|retromer, cargo-selective complex|intracellular organelle|ion binding|cellular localization|membrane-bounded organelle|retromer complex|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|protein transporter activity|transport|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|establishment of protein localization|protein localization|extracellular exosome|establishment of localization in cell|endosome membrane|endosome|vesicle-mediated transport|cytosol|metal ion binding|early endosome|protein transport|intracellular transport|late endosome|cellular protein localization|retrograde transport, endosome to Golgi|cytosolic transport|intracellular protein transport|retrograde transport, endosome to plasma membrane|endosomal transport K18467 vacuolar protein sorting-associated protein 29[-] hsa04144 Endocytosis - Homo sapiens (human) 12:110491097-110502117 456 546 544 1237 1090 1107 4.12007008636964 4.48344971062558 4.43151434528801 10.0139805554802 8.08041908710506 9.37380991537062 4.34501138076108 9.15606985265196 -1.07536851355934 3.05328003203022e-07 4.25152155206298e-06 DOWN ENSG00000138594 TMOD3 tropomodulin 3 [Source:HGNC Symbol;Acc:HGNC:11873] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0002262|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0048646|GO:0030017|GO:0051726|GO:0007049|GO:0048468|GO:0022402|GO:0007275|GO:0048513|GO:0034101|GO:0032535|GO:0051128|GO:0022607|GO:0061061|GO:0005737|GO:0032970|GO:0003012|GO:0042592|GO:0045787|GO:0008092|GO:0048869|GO:0030029|GO:0043254|GO:0006996|GO:0031333|GO:0006936|GO:0030218|GO:0090068|GO:0032956|GO:0005865|GO:1903047|GO:0007010|GO:0030097|GO:0042692|GO:0005523|GO:0003779|GO:0044770|GO:0000278|GO:0048872|GO:0043292|GO:0043242|GO:0007346|GO:0010564|GO:0006461|GO:0055001|GO:0043244|GO:0030036|GO:0070925|GO:0033043|GO:0030154|GO:0030832|GO:0030239|GO:0045931|GO:0005856|GO:0055002|GO:0015629|GO:0043241|GO:0030016|GO:0034622|GO:0044772|GO:0043623|GO:0008064|GO:1901990|GO:0051494|GO:0051493|GO:1901989|GO:1901992|GO:0032272|GO:0051146|GO:1901879|GO:1901987|GO:0048821|GO:0030099|GO:0031032|GO:0007015|GO:0030833|GO:0051258|GO:0043624|GO:0030837|GO:0030834|GO:0008154|GO:0030835|GO:0051693|GO:0030042|GO:0030041|GO:0051261|GO:0051694 developmental process|immune system process|cell|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|myeloid cell homeostasis|intracellular|immune system development|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|sarcomere|regulation of cell cycle|cell cycle|cell development|cell cycle process|multicellular organism development|animal organ development|erythrocyte homeostasis|regulation of cellular component size|regulation of cellular component organization|cellular component assembly|muscle structure development|cytoplasm|regulation of actin filament-based process|muscle system process|homeostatic process|positive regulation of cell cycle|cytoskeletal protein binding|cellular developmental process|actin filament-based process|regulation of protein complex assembly|organelle organization|negative regulation of protein complex assembly|muscle contraction|erythrocyte differentiation|positive regulation of cell cycle process|regulation of actin cytoskeleton organization|striated muscle thin filament|mitotic cell cycle process|cytoskeleton organization|hemopoiesis|muscle cell differentiation|tropomyosin binding|actin binding|cell cycle phase transition|mitotic cell cycle|homeostasis of number of cells|contractile fiber|negative regulation of protein complex disassembly|regulation of mitotic cell cycle|regulation of cell cycle process|protein complex assembly|muscle cell development|regulation of protein complex disassembly|actin cytoskeleton organization|organelle assembly|regulation of organelle organization|cell differentiation|regulation of actin filament length|myofibril assembly|positive regulation of mitotic cell cycle|cytoskeleton|striated muscle cell development|actin cytoskeleton|protein complex disassembly|myofibril|cellular macromolecular complex assembly|mitotic cell cycle phase transition|cellular protein complex assembly|regulation of actin polymerization or depolymerization|regulation of mitotic cell cycle phase transition|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|negative regulation of protein polymerization|striated muscle cell differentiation|regulation of protein depolymerization|regulation of cell cycle phase transition|erythrocyte development|myeloid cell differentiation|actomyosin structure organization|actin filament organization|regulation of actin filament polymerization|protein polymerization|cellular protein complex disassembly|negative regulation of actin filament polymerization|regulation of actin filament depolymerization|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|actin filament capping|actin filament depolymerization|actin filament polymerization|protein depolymerization|pointed-end actin filament capping - - - - 15:51829628-51947295 864 1068 1550 2490 2889 2634 4.41466683097495 4.9594697681134 7.14052615988615 11.3993788774501 12.1115461781583 12.6133042498038 5.50488758632483 12.0414097684707 -1.12921929959862 3.06843957474114e-07 4.27063846453716e-06 DOWN ENSG00000106477 CEP41 centrosomal protein 41kDa [Source:HGNC Symbol;Acc:HGNC:12370] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0042995|GO:0043229|GO:0071704|GO:0009986|GO:0044237|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0048646|GO:0007049|GO:0016337|GO:0006810|GO:0022402|GO:0022607|GO:0098609|GO:0005737|GO:0045184|GO:0072372|GO:0036064|GO:0008104|GO:0030030|GO:0048869|GO:0019538|GO:0006996|GO:0000902|GO:0005829|GO:0005813|GO:1903047|GO:0043412|GO:0005815|GO:0044770|GO:0015031|GO:0005814|GO:0036211|GO:0044782|GO:0000278|GO:0030031|GO:0070925|GO:0042384|GO:0044267|GO:0032990|GO:0048858|GO:0005856|GO:0060271|GO:0000086|GO:0044772|GO:0015630|GO:0006464|GO:0018193|GO:0018095 developmental process|cell|membrane|cellular process|metabolic process|cell junction|binding|cell projection|intracellular organelle|organic substance metabolic process|cell surface|cellular metabolic process|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|cell cycle|single organismal cell-cell adhesion|transport|cell cycle process|cellular component assembly|cell-cell adhesion|cytoplasm|establishment of protein localization|primary cilium|ciliary basal body|protein localization|cell projection organization|cellular developmental process|protein metabolic process|organelle organization|cell morphogenesis|cytosol|centrosome|mitotic cell cycle process|macromolecule modification|microtubule organizing center|cell cycle phase transition|protein transport|centriole|protein modification process|cilium organization|mitotic cell cycle|cell projection assembly|organelle assembly|cilium assembly|cellular protein metabolic process|cell part morphogenesis|cell projection morphogenesis|cytoskeleton|cilium morphogenesis|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|microtubule cytoskeleton|cellular protein modification process|peptidyl-amino acid modification|protein polyglutamylation - - - - 7:130393771-130442433 171 138 155 404 440 385 0.641391509740806 0.470419835988737 0.524172248807069 1.35770883484833 1.35408966969711 1.35336896040032 0.545327864845537 1.35505582164859 -1.31315650431358 3.09523166731212e-07 4.30443881721557e-06 DOWN ENSG00000142949 PTPRF protein tyrosine phosphatase, receptor type, F [Source:HGNC Symbol;Acc:HGNC:9670] GO:0040011|GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0004872|GO:0044877|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0048870|GO:0044297|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0016787|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0008201|GO:0045595|GO:0048468|GO:0043025|GO:0007275|GO:0043168|GO:0016788|GO:0031982|GO:0051128|GO:0033554|GO:0051098|GO:0005887|GO:0004888|GO:0009611|GO:0006928|GO:0032403|GO:0043005|GO:0036477|GO:0031226|GO:0007154|GO:0044092|GO:0016477|GO:0007165|GO:0070062|GO:0035373|GO:0030030|GO:0001948|GO:0048869|GO:0016021|GO:0019538|GO:0005539|GO:0070570|GO:0031175|GO:0031344|GO:0007166|GO:0051100|GO:0031102|GO:0043412|GO:0048678|GO:0036211|GO:0043394|GO:0048679|GO:0006796|GO:0044267|GO:0007399|GO:0030154|GO:0042578|GO:0051960|GO:0043393|GO:0048666|GO:0030182|GO:0016311|GO:0010975|GO:0061564|GO:0007167|GO:0016791|GO:0022008|GO:0006464|GO:0031103|GO:0050767|GO:0032091|GO:0005001|GO:0006470|GO:0048699|GO:0004721|GO:0045664|GO:0007185|GO:1900121|GO:0035335|GO:0004725 locomotion|developmental process|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|receptor activity|macromolecular complex binding|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|cell motility|cell body|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|hydrolase activity|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|heparin binding|regulation of cell differentiation|cell development|neuronal cell body|multicellular organism development|anion binding|hydrolase activity, acting on ester bonds|vesicle|regulation of cellular component organization|cellular response to stress|regulation of binding|integral component of plasma membrane|transmembrane signaling receptor activity|response to wounding|movement of cell or subcellular component|protein complex binding|neuron projection|somatodendritic compartment|intrinsic component of plasma membrane|cell communication|negative regulation of molecular function|cell migration|signal transduction|extracellular exosome|chondroitin sulfate proteoglycan binding|cell projection organization|glycoprotein binding|cellular developmental process|integral component of membrane|protein metabolic process|glycosaminoglycan binding|regulation of neuron projection regeneration|neuron projection development|regulation of cell projection organization|cell surface receptor signaling pathway|negative regulation of binding|neuron projection regeneration|macromolecule modification|response to axon injury|protein modification process|proteoglycan binding|regulation of axon regeneration|phosphate-containing compound metabolic process|cellular protein metabolic process|nervous system development|cell differentiation|phosphoric ester hydrolase activity|regulation of nervous system development|regulation of protein binding|neuron development|neuron differentiation|dephosphorylation|regulation of neuron projection development|axon development|enzyme linked receptor protein signaling pathway|phosphatase activity|neurogenesis|cellular protein modification process|axon regeneration|regulation of neurogenesis|negative regulation of protein binding|transmembrane receptor protein tyrosine phosphatase activity|protein dephosphorylation|generation of neurons|phosphoprotein phosphatase activity|regulation of neuron differentiation|transmembrane receptor protein tyrosine phosphatase signaling pathway|negative regulation of receptor binding|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity K05695 receptor-type tyrosine-protein phosphatase F[3.1.3.48] hsa04514|hsa04910|hsa04931|hsa04520 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Adherens junction - Homo sapiens (human) 1:43525187-43623666 2774 3021 4721 7032 8488 11218 9.88434654589753 9.78300490644719 15.1666502390147 22.4500882465063 24.8150287930127 37.4615583228276 11.6113338971198 28.2422251207822 -1.28232004180626 3.12918046460027e-07 4.34909467365812e-06 DOWN ENSG00000151338 MIPOL1 mirror-image polydactyly 1 [Source:HGNC Symbol;Acc:HGNC:21460] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|nucleus - - - - 14:37197913-37552361 110 110 200 336 410 451 0.286646646861029 0.260512183779615 0.469894148372592 0.784500319600809 0.876612113863449 1.10144072768916 0.339017659671079 0.920851053717806 -1.44160739508933 3.14456708908505e-07 4.36844606224034e-06 DOWN ENSG00000164920 OSR2 odd-skipped related transciption factor 2 [Source:HGNC Symbol;Acc:HGNC:15830] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:0001822|GO:0009888|GO:1901360|GO:0007275|GO:0033687|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0070169|GO:0043231|GO:0043169|GO:0000981|GO:0060322|GO:0007423|GO:0009887|GO:0048598|GO:0048568|GO:0050673|GO:0009890|GO:0006139|GO:0045778|GO:0061029|GO:0030278|GO:0001503|GO:0060348|GO:0048869|GO:0044249|GO:0031324|GO:0040019|GO:0031323|GO:0060021|GO:0050679|GO:0030501|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0051216|GO:0046872|GO:0042733|GO:0001654|GO:0001655|GO:0010629|GO:0043583|GO:0048793|GO:0051252|GO:0031214|GO:0009790|GO:0001656|GO:0010628|GO:0042474|GO:0007369|GO:0072001|GO:0050678|GO:0042476|GO:0035108|GO:0010467|GO:0048562|GO:0060349|GO:0031328|GO:2000543|GO:0010470|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0001228|GO:0001823|GO:0060173|GO:0016070|GO:0010557|GO:0005634|GO:0030282|GO:0036023|GO:0045995|GO:0030500|GO:0048706|GO:0000975|GO:0045893|GO:0009792|GO:0045892|GO:0043010|GO:0002062|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0042471|GO:0035136|GO:0048704|GO:0035137|GO:0030326|GO:0006351|GO:0006355|GO:0035115|GO:0035116|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0072498|GO:0060272|GO:0043009|GO:0000122|GO:0000976|GO:0001012|GO:0000977 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|kidney development|tissue development|organic cyclic compound metabolic process|multicellular organism development|osteoblast proliferation|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of biomineral tissue development|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|sensory organ development|organ morphogenesis|embryonic morphogenesis|embryonic organ development|epithelial cell proliferation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|positive regulation of ossification|eyelid development in camera-type eye|regulation of ossification|ossification|bone development|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|positive regulation of embryonic development|regulation of cellular metabolic process|palate development|positive regulation of epithelial cell proliferation|positive regulation of bone mineralization|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|metal ion binding|embryonic digit morphogenesis|eye development|urogenital system development|negative regulation of gene expression|ear development|pronephros development|regulation of RNA metabolic process|biomineral tissue development|embryo development|metanephros development|positive regulation of gene expression|middle ear morphogenesis|gastrulation|renal system development|regulation of epithelial cell proliferation|odontogenesis|limb morphogenesis|gene expression|embryonic organ morphogenesis|bone morphogenesis|positive regulation of cellular biosynthetic process|positive regulation of gastrulation|regulation of gastrulation|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|mesonephros development|limb development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|bone mineralization|embryonic skeletal limb joint morphogenesis|regulation of embryonic development|regulation of bone mineralization|embryonic skeletal system development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|negative regulation of transcription, DNA-templated|camera-type eye development|chondrocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|ear morphogenesis|forelimb morphogenesis|embryonic skeletal system morphogenesis|hindlimb morphogenesis|embryonic limb morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|embryonic skeletal joint development|embryonic skeletal joint morphogenesis|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 8:98944403-98952104 311 323 430 167 197 143 2.96324961228276 2.79698666435847 3.69394236620362 1.42568019062165 1.54007482751321 1.27694778741521 3.15139288094828 1.41423426851669 1.15596850189339 3.14891243525961e-07 4.37244799266234e-06 UP ENSG00000149311 ATM ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795] GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0002683|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0090220|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0048609|GO:0019222|GO:0007507|GO:0047485|GO:0051726|GO:0042127|GO:0007049|GO:0007131|GO:0044255|GO:0006281|GO:0001756|GO:0006725|GO:0051640|GO:0070661|GO:0009888|GO:0048468|GO:0009314|GO:0009994|GO:0022402|GO:0051130|GO:1901360|GO:2001022|GO:0010941|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0051302|GO:0034641|GO:0043168|GO:0032204|GO:0001882|GO:0016772|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0007420|GO:0010942|GO:0032206|GO:0045786|GO:0043231|GO:0000723|GO:0005737|GO:0007389|GO:0060322|GO:0009408|GO:0032403|GO:0042592|GO:0051656|GO:0001775|GO:0009966|GO:0046983|GO:0051782|GO:0045787|GO:0070192|GO:0045141|GO:0010646|GO:0006139|GO:0008340|GO:0046649|GO:0050865|GO:0007154|GO:0007276|GO:0006629|GO:0007165|GO:0007126|GO:0051983|GO:0051649|GO:0006975|GO:0008219|GO:0002695|GO:0008285|GO:0001666|GO:0007059|GO:0000166|GO:0051301|GO:0048869|GO:0009967|GO:0044249|GO:0009266|GO:0019538|GO:1990391|GO:0031324|GO:0007281|GO:0031323|GO:0006996|GO:0007568|GO:1900034|GO:0051276|GO:1902533|GO:0051249|GO:0032268|GO:0003677|GO:0007004|GO:0000819|GO:0042113|GO:0010468|GO:0000075|GO:0008654|GO:0034645|GO:0032943|GO:0046486|GO:0090068|GO:0000725|GO:0010833|GO:0035639|GO:1903047|GO:0043412|GO:0030097|GO:0072358|GO:0030163|GO:0030098|GO:0007417|GO:0031410|GO:0016572|GO:0051304|GO:0031056|GO:0006325|GO:0001883|GO:1901216|GO:0070997|GO:0044770|GO:0044265|GO:0007050|GO:0048477|GO:0009790|GO:0031058|GO:0006302|GO:0016023|GO:0033151|GO:0036211|GO:0032269|GO:0000278|GO:1904358|GO:0032549|GO:0043517|GO:0010259|GO:0051250|GO:0003002|GO:0007127|GO:0007569|GO:0042157|GO:0031981|GO:2001020|GO:0045132|GO:0007346|GO:0010564|GO:0071478|GO:0034605|GO:0051247|GO:0045930|GO:0006508|GO:0031988|GO:0005654|GO:0070664|GO:0006259|GO:0005694|GO:0016301|GO:1901214|GO:0032270|GO:0012501|GO:0060429|GO:0051054|GO:0006796|GO:0010212|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0042176|GO:0007067|GO:0010467|GO:0008610|GO:0007399|GO:0017076|GO:0031328|GO:0019439|GO:0051246|GO:1904356|GO:0046651|GO:0009059|GO:0030154|GO:0043068|GO:0072395|GO:0048599|GO:1902531|GO:0016070|GO:0072359|GO:0042177|GO:0016773|GO:0007292|GO:0005856|GO:0010557|GO:0005634|GO:0005819|GO:0043067|GO:0006644|GO:0006974|GO:0051303|GO:0097190|GO:0010948|GO:0010638|GO:2001252|GO:0002521|GO:0006401|GO:0006303|GO:0044257|GO:0031577|GO:0000724|GO:0010332|GO:0097193|GO:0009792|GO:0031401|GO:0032200|GO:0006260|GO:0000781|GO:1901798|GO:0043065|GO:2001251|GO:0071156|GO:0010498|GO:0030183|GO:0050869|GO:0046474|GO:0042159|GO:0043523|GO:0007093|GO:0035004|GO:0072331|GO:0042770|GO:0000086|GO:0007088|GO:1903363|GO:0005524|GO:0044772|GO:0030162|GO:0007094|GO:0043525|GO:0030554|GO:0016310|GO:0071174|GO:0033044|GO:0044774|GO:0000077|GO:0032212|GO:1901990|GO:0061053|GO:0045143|GO:0051603|GO:0045839|GO:0015630|GO:0008630|GO:0016071|GO:0050864|GO:0006275|GO:0006310|GO:1901796|GO:0000070|GO:0002331|GO:0042981|GO:0009952|GO:0090399|GO:0051306|GO:0045861|GO:0004672|GO:0016568|GO:0007095|GO:1901987|GO:0051402|GO:0071479|GO:0042100|GO:0007091|GO:0032945|GO:0045740|GO:0033129|GO:0006464|GO:0050672|GO:0032210|GO:0006650|GO:0035282|GO:0006915|GO:0043516|GO:0044773|GO:1901991|GO:0071158|GO:0030071|GO:0071173|GO:2000045|GO:0006278|GO:0016303|GO:0002327|GO:0010389|GO:0044818|GO:0046488|GO:0010972|GO:0044819|GO:0072434|GO:0010965|GO:0019941|GO:0006468|GO:0071480|GO:1902750|GO:0006402|GO:0045003|GO:0044783|GO:0006661|GO:0008334|GO:0042325|GO:0001932|GO:1902806|GO:0018193|GO:0016444|GO:2000134|GO:0000082|GO:0004674|GO:0043009|GO:1901799|GO:0030889|GO:2000816|GO:0030888|GO:0001934|GO:1902749|GO:1903051|GO:0031571|GO:0061136|GO:0042327|GO:1902807|GO:0006977|GO:0030330|GO:0043161|GO:0072422|GO:0031572|GO:0072431|GO:0006511|GO:0036092|GO:0002329|GO:0071044|GO:0000956|GO:0046777|GO:0032434|GO:0032435|GO:0018105|GO:0004677|GO:0036289 developmental process|macromolecular complex|reproduction|immune system process|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|chromosome localization to nuclear envelope involved in homologous chromosome segregation|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|heart development|protein N-terminus binding|regulation of cell cycle|regulation of cell proliferation|cell cycle|reciprocal meiotic recombination|cellular lipid metabolic process|DNA repair|somitogenesis|cellular aromatic compound metabolic process|organelle localization|leukocyte proliferation|tissue development|cell development|response to radiation|oocyte differentiation|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|regulation of cell death|multicellular organism development|histone modification|nucleic acid binding|animal organ development|regulation of cell division|cellular nitrogen compound metabolic process|anion binding|regulation of telomere maintenance|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|brain development|positive regulation of cell death|positive regulation of telomere maintenance|negative regulation of cell cycle|intracellular membrane-bounded organelle|telomere maintenance|cytoplasm|pattern specification process|head development|response to heat|protein complex binding|homeostatic process|establishment of organelle localization|cell activation|regulation of signal transduction|protein dimerization activity|negative regulation of cell division|positive regulation of cell cycle|chromosome organization involved in meiotic cell cycle|meiotic telomere clustering|regulation of cell communication|nucleobase-containing compound metabolic process|determination of adult lifespan|lymphocyte activation|regulation of cell activation|cell communication|gamete generation|lipid metabolic process|signal transduction|meiotic nuclear division|regulation of chromosome segregation|establishment of localization in cell|DNA damage induced protein phosphorylation|cell death|negative regulation of leukocyte activation|negative regulation of cell proliferation|response to hypoxia|chromosome segregation|nucleotide binding|cell division|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|DNA repair complex|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|organelle organization|aging|regulation of cellular response to heat|chromosome organization|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|DNA binding|telomere maintenance via telomerase|sister chromatid segregation|B cell activation|regulation of gene expression|cell cycle checkpoint|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|mononuclear cell proliferation|glycerolipid metabolic process|positive regulation of cell cycle process|recombinational repair|telomere maintenance via telomere lengthening|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|hemopoiesis|cardiovascular system development|protein catabolic process|lymphocyte differentiation|central nervous system development|cytoplasmic vesicle|histone phosphorylation|chromosome separation|regulation of histone modification|chromatin organization|purine nucleoside binding|positive regulation of neuron death|neuron death|cell cycle phase transition|cellular macromolecule catabolic process|cell cycle arrest|oogenesis|embryo development|positive regulation of histone modification|double-strand break repair|cytoplasmic, membrane-bounded vesicle|V(D)J recombination|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|positive regulation of telomere maintenance via telomere lengthening|ribonucleoside binding|positive regulation of DNA damage response, signal transduction by p53 class mediator|multicellular organism aging|negative regulation of lymphocyte activation|regionalization|meiosis I|cell aging|lipoprotein metabolic process|nuclear lumen|regulation of response to DNA damage stimulus|meiotic chromosome segregation|regulation of mitotic cell cycle|regulation of cell cycle process|cellular response to radiation|cellular response to heat|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|proteolysis|membrane-bounded vesicle|nucleoplasm|negative regulation of leukocyte proliferation|DNA metabolic process|chromosome|kinase activity|regulation of neuron death|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|response to ionizing radiation|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|mitotic nuclear division|gene expression|lipid biosynthetic process|nervous system development|purine nucleotide binding|positive regulation of cellular biosynthetic process|aromatic compound catabolic process|regulation of protein metabolic process|regulation of telomere maintenance via telomere lengthening|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|signal transduction involved in cell cycle checkpoint|oocyte development|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|negative regulation of protein catabolic process|phosphotransferase activity, alcohol group as acceptor|female gamete generation|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|spindle|regulation of programmed cell death|phospholipid metabolic process|cellular response to DNA damage stimulus|establishment of chromosome localization|apoptotic signaling pathway|negative regulation of cell cycle process|positive regulation of organelle organization|positive regulation of chromosome organization|leukocyte differentiation|RNA catabolic process|double-strand break repair via nonhomologous end joining|cellular protein catabolic process|spindle checkpoint|double-strand break repair via homologous recombination|response to gamma radiation|intrinsic apoptotic signaling pathway|embryo development ending in birth or egg hatching|positive regulation of protein modification process|telomere organization|DNA replication|chromosome, telomeric region|positive regulation of signal transduction by p53 class mediator|positive regulation of apoptotic process|negative regulation of chromosome organization|regulation of cell cycle arrest|proteasomal protein catabolic process|B cell differentiation|negative regulation of B cell activation|glycerophospholipid biosynthetic process|lipoprotein catabolic process|regulation of neuron apoptotic process|mitotic cell cycle checkpoint|phosphatidylinositol 3-kinase activity|signal transduction by p53 class mediator|signal transduction in response to DNA damage|G2/M transition of mitotic cell cycle|regulation of mitotic nuclear division|negative regulation of cellular protein catabolic process|ATP binding|mitotic cell cycle phase transition|regulation of proteolysis|mitotic spindle assembly checkpoint|positive regulation of neuron apoptotic process|adenyl nucleotide binding|phosphorylation|mitotic spindle checkpoint|regulation of chromosome organization|mitotic DNA integrity checkpoint|DNA damage checkpoint|positive regulation of telomere maintenance via telomerase|regulation of mitotic cell cycle phase transition|somite development|homologous chromosome segregation|proteolysis involved in cellular protein catabolic process|negative regulation of mitotic nuclear division|microtubule cytoskeleton|intrinsic apoptotic signaling pathway in response to DNA damage|mRNA metabolic process|regulation of B cell activation|regulation of DNA replication|DNA recombination|regulation of signal transduction by p53 class mediator|mitotic sister chromatid segregation|pre-B cell allelic exclusion|regulation of apoptotic process|anterior/posterior pattern specification|replicative senescence|mitotic sister chromatid separation|negative regulation of proteolysis|protein kinase activity|chromatin modification|mitotic G2 DNA damage checkpoint|regulation of cell cycle phase transition|neuron apoptotic process|cellular response to ionizing radiation|B cell proliferation|metaphase/anaphase transition of mitotic cell cycle|negative regulation of mononuclear cell proliferation|positive regulation of DNA replication|positive regulation of histone phosphorylation|cellular protein modification process|negative regulation of lymphocyte proliferation|regulation of telomere maintenance via telomerase|glycerophospholipid metabolic process|segmentation|apoptotic process|regulation of DNA damage response, signal transduction by p53 class mediator|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|regulation of mitotic metaphase/anaphase transition|spindle assembly checkpoint|regulation of G1/S transition of mitotic cell cycle|RNA-dependent DNA replication|1-phosphatidylinositol-3-kinase activity|immature B cell differentiation|regulation of G2/M transition of mitotic cell cycle|mitotic G2/M transition checkpoint|phosphatidylinositol metabolic process|negative regulation of G2/M transition of mitotic cell cycle|mitotic G1/S transition checkpoint|signal transduction involved in mitotic G2 DNA damage checkpoint|regulation of mitotic sister chromatid separation|modification-dependent protein catabolic process|protein phosphorylation|cellular response to gamma radiation|negative regulation of cell cycle G2/M phase transition|mRNA catabolic process|double-strand break repair via synthesis-dependent strand annealing|G1 DNA damage checkpoint|phosphatidylinositol biosynthetic process|histone mRNA metabolic process|regulation of phosphorylation|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|peptidyl-amino acid modification|somatic cell DNA recombination|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|chordate embryonic development|negative regulation of proteasomal protein catabolic process|negative regulation of B cell proliferation|negative regulation of mitotic sister chromatid separation|regulation of B cell proliferation|positive regulation of protein phosphorylation|regulation of cell cycle G2/M phase transition|negative regulation of proteolysis involved in cellular protein catabolic process|mitotic G1 DNA damage checkpoint|regulation of proteasomal protein catabolic process|positive regulation of phosphorylation|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|proteasome-mediated ubiquitin-dependent protein catabolic process|signal transduction involved in DNA damage checkpoint|G2 DNA damage checkpoint|signal transduction involved in mitotic G1 DNA damage checkpoint|ubiquitin-dependent protein catabolic process|phosphatidylinositol-3-phosphate biosynthetic process|pre-B cell differentiation|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process|protein autophosphorylation|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|peptidyl-serine phosphorylation|DNA-dependent protein kinase activity|peptidyl-serine autophosphorylation K04728 ataxia telangiectasia mutated family protein[2.7.11.1] hsa05166|hsa05206|hsa05202|hsa04210|hsa04068|hsa04110|hsa04064|hsa04115 HTLV-I infection - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 11:108222484-108369102 258 302 463 728 813 1099 0.561473068944199 0.597303877303685 0.908456512072679 1.41950904075457 1.45166759268407 2.24148416649226 0.689077819440188 1.70422026664363 -1.30637298797606 3.16184158477678e-07 4.38835977089381e-06 DOWN ENSG00000012211 PRICKLE3 prickle homolog 3 [Source:HGNC Symbol;Acc:HGNC:6645] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|protein binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - X:49175264-49186528 530 572 535 254 332 250 6.03420427284707 5.91862186359947 5.49176834306555 2.59105482318359 3.1013488178187 2.6675602522037 5.81486482650403 2.78665463106866 1.0612114443349 3.17144322862686e-07 4.39964062023356e-06 UP ENSG00000225828 FAM229A family with sequence similarity 229 member A [Source:HGNC Symbol;Acc:HGNC:44652] - - - - - - 1:32361270-32364278 34 31 71 130 189 163 0.563777229755135 0.467167554877877 1.0614490317009 1.93137701970003 2.57131790533967 2.5330324226033 0.697464605444637 2.34524244921433 -1.74954516425719 3.20306514760208e-07 4.44144481730202e-06 DOWN ENSG00000032742 IFT88 intraflagellar transport 88 [Source:HGNC Symbol;Acc:HGNC:20606] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0006950|GO:0009056|GO:0044237|GO:0006914|GO:0009653|GO:0016043|GO:0009605|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0019222|GO:0030992|GO:0010506|GO:1902115|GO:0009991|GO:0030990|GO:0051128|GO:0033554|GO:0022607|GO:0031514|GO:0005737|GO:0072372|GO:0036064|GO:0010646|GO:0007154|GO:0060491|GO:0097542|GO:0016236|GO:0030030|GO:0048869|GO:0031323|GO:0006996|GO:0000902|GO:0005813|GO:0031344|GO:0005815|GO:2000785|GO:1902017|GO:0005814|GO:0044782|GO:0016241|GO:0030031|GO:0022604|GO:0070925|GO:0042384|GO:0033043|GO:0032990|GO:0048858|GO:0000045|GO:0031667|GO:0005856|GO:0007033|GO:0060271|GO:0044088|GO:0015630 developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|response to stress|catabolic process|cellular metabolic process|autophagy|anatomical structure morphogenesis|cellular component organization|response to external stimulus|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|intraciliary transport particle B|regulation of autophagy|regulation of organelle assembly|response to extracellular stimulus|intraciliary transport particle|regulation of cellular component organization|cellular response to stress|cellular component assembly|motile cilium|cytoplasm|primary cilium|ciliary basal body|regulation of cell communication|cell communication|regulation of cell projection assembly|ciliary tip|macroautophagy|cell projection organization|cellular developmental process|regulation of cellular metabolic process|organelle organization|cell morphogenesis|centrosome|regulation of cell projection organization|microtubule organizing center|regulation of autophagosome assembly|regulation of cilium assembly|centriole|cilium organization|regulation of macroautophagy|cell projection assembly|regulation of cell morphogenesis|organelle assembly|cilium assembly|regulation of organelle organization|cell part morphogenesis|cell projection morphogenesis|autophagosome assembly|response to nutrient levels|cytoskeleton|vacuole organization|cilium morphogenesis|regulation of vacuole organization|microtubule cytoskeleton - - - - 13:20567069-20691437 120 125 172 347 402 325 1.07762157159746 1.02017813692288 1.39260606195503 2.79197898884513 2.96196045392208 2.7352477953883 1.16346859015846 2.82972907938517 -1.28223167161834 3.21462422052642e-07 4.4554035041595e-06 DOWN ENSG00000066084 DIP2B disco interacting protein 2 homolog B [Source:HGNC Symbol;Acc:HGNC:29284] GO:0005623|GO:0016020|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0031982|GO:0043231|GO:0005737|GO:0070062|GO:0008134|GO:0005634 cell|membrane|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|vesicle|intracellular membrane-bounded organelle|cytoplasm|extracellular exosome|transcription factor binding|nucleus - - - - 12:50504985-50748667 505 583 896 1436 1667 1520 3.09550597426519 3.24779268082802 4.95179082541361 7.88664009265481 8.38384845175325 8.73197187802889 3.76502982683561 8.33415347414565 -1.14637437356128 3.22166318140305e-07 4.46308736044579e-06 DOWN ENSG00000074416 MGLL monoglyceride lipase [Source:HGNC Symbol;Acc:HGNC:17038] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0019898|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0009605|GO:0016787|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0042802|GO:0044255|GO:0050817|GO:0006082|GO:0050877|GO:0016788|GO:0044281|GO:0006952|GO:0019637|GO:0043231|GO:0005737|GO:0009611|GO:0001775|GO:0009966|GO:0046983|GO:0010646|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0044249|GO:0010033|GO:0050878|GO:0005829|GO:0007186|GO:0008654|GO:0030168|GO:0046486|GO:0038171|GO:0050727|GO:0008277|GO:0016042|GO:0007596|GO:0044242|GO:0006631|GO:0042060|GO:0006954|GO:0007600|GO:0006638|GO:0031981|GO:0007599|GO:0031644|GO:0005654|GO:0016298|GO:0006796|GO:0008610|GO:0005634|GO:0052689|GO:0042803|GO:0006644|GO:0006690|GO:0004620|GO:0033559|GO:0004622|GO:0047372|GO:0019233|GO:0046474|GO:0001676|GO:0046461|GO:0019369|GO:0006633|GO:0071926|GO:0019752|GO:0006639|GO:0006650|GO:2000124|GO:0051930|GO:0046464|GO:0036155|GO:0032787|GO:0006641|GO:0019433 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|extrinsic component of membrane|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|response to external stimulus|hydrolase activity|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|identical protein binding|cellular lipid metabolic process|coagulation|organic acid metabolic process|neurological system process|hydrolase activity, acting on ester bonds|small molecule metabolic process|defense response|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|response to wounding|cell activation|regulation of signal transduction|protein dimerization activity|regulation of cell communication|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|cellular biosynthetic process|response to organic substance|regulation of body fluid levels|cytosol|G-protein coupled receptor signaling pathway|phospholipid biosynthetic process|platelet activation|glycerolipid metabolic process|cannabinoid signaling pathway|regulation of inflammatory response|regulation of G-protein coupled receptor protein signaling pathway|lipid catabolic process|blood coagulation|cellular lipid catabolic process|fatty acid metabolic process|wound healing|inflammatory response|sensory perception|neutral lipid metabolic process|nuclear lumen|hemostasis|regulation of neurological system process|nucleoplasm|lipase activity|phosphate-containing compound metabolic process|lipid biosynthetic process|nucleus|carboxylic ester hydrolase activity|protein homodimerization activity|phospholipid metabolic process|icosanoid metabolic process|phospholipase activity|unsaturated fatty acid metabolic process|lysophospholipase activity|acylglycerol lipase activity|sensory perception of pain|glycerophospholipid biosynthetic process|long-chain fatty acid metabolic process|neutral lipid catabolic process|arachidonic acid metabolic process|fatty acid biosynthetic process|endocannabinoid signaling pathway|carboxylic acid metabolic process|acylglycerol metabolic process|glycerophospholipid metabolic process|regulation of endocannabinoid signaling pathway|regulation of sensory perception of pain|acylglycerol catabolic process|acylglycerol acyl-chain remodeling|monocarboxylic acid metabolic process|triglyceride metabolic process|triglyceride catabolic process K01054 acylglycerol lipase[3.1.1.23] hsa01100|hsa04723|hsa00561|hsa04923 Metabolic pathways - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human)|Regulation of lipolysis in adipocytes - Homo sapiens (human) 3:127689062-127823250 377 460 890 1461 1576 1523 1.71806333326974 1.90518102085348 3.65680954859508 5.96548872086724 5.89280531862291 6.50469547901926 2.42668463423943 6.1209965061698 -1.33477991296845 3.22616498905624e-07 4.46725090831563e-06 DOWN ENSG00000263624 RP11-45M22.3 - - - - - - - 17:17167946-17185554 0 1 0 10 11 12 0 0.0522483564069369 0 0.514872888763889 0.518606739791398 0.646222145640145 0.0174161188023123 0.559900591398477 -5.00667564492244 3.23548988938459e-07 4.47808600638329e-06 DOWN ENSG00000144063 MALL mal, T-cell differentiation protein-like [Source:HGNC Symbol;Acc:HGNC:6818] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0031982|GO:0043231|GO:0005737|GO:0042592|GO:0016021|GO:0098857|GO:0005794|GO:0031410|GO:0048878|GO:0016023|GO:0031988|GO:0000139|GO:0045121|GO:0030135|GO:0055088|GO:0030136|GO:0055092|GO:0042632 cell|membrane|binding|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|vesicle|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|integral component of membrane|membrane microdomain|Golgi apparatus|cytoplasmic vesicle|chemical homeostasis|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|Golgi membrane|membrane raft|coated vesicle|lipid homeostasis|clathrin-coated vesicle|sterol homeostasis|cholesterol homeostasis - - - - 2:110083870-110116566 210 236 341 853 875 476 3.36307693651882 3.43486603818438 4.9236469028464 12.2395381264629 11.4972633886712 7.14420732121719 3.90719662584987 10.2936696121171 -1.39755161866456 3.26831666464008e-07 4.52142380473424e-06 DOWN ENSG00000102580 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 [Source:HGNC Symbol;Acc:HGNC:9439] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0051726|GO:0007049|GO:0004857|GO:0010941|GO:0034641|GO:0006952|GO:0030867|GO:0031982|GO:0031325|GO:0033554|GO:0098542|GO:0043231|GO:0051087|GO:0006413|GO:0019899|GO:1903573|GO:0005737|GO:0009615|GO:0060548|GO:0051787|GO:0007154|GO:0044092|GO:0007165|GO:0005783|GO:0070062|GO:0009409|GO:0008219|GO:0051607|GO:0050790|GO:0010998|GO:0019207|GO:0043086|GO:0031205|GO:0044249|GO:0009266|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0036492|GO:0032268|GO:0005829|GO:0070417|GO:0019210|GO:0010468|GO:0034645|GO:0043555|GO:0006518|GO:0030968|GO:0043412|GO:0030163|GO:0019887|GO:0043069|GO:0006446|GO:0044265|GO:0005790|GO:0010628|GO:1903912|GO:0036211|GO:0032269|GO:0005791|GO:0006986|GO:0051247|GO:0006508|GO:0019900|GO:0032270|GO:0012501|GO:0006796|GO:0043603|GO:0044267|GO:0051174|GO:0045948|GO:0010467|GO:0005788|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0035967|GO:0034976|GO:0010557|GO:0043067|GO:0034620|GO:0044257|GO:0043043|GO:0036498|GO:0032058|GO:0045727|GO:0016310|GO:0010608|GO:1904030|GO:0006412|GO:0051603|GO:0006417|GO:0043558|GO:0004860|GO:0042981|GO:0043066|GO:0033673|GO:0019901|GO:0006464|GO:0043549|GO:0006915|GO:0045859|GO:0006469|GO:0006468|GO:0036493|GO:0042325|GO:0001932|GO:0042326|GO:0036494|GO:0001933 macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cell cycle|cell cycle|enzyme inhibitor activity|regulation of cell death|cellular nitrogen compound metabolic process|defense response|rough endoplasmic reticulum membrane|vesicle|positive regulation of cellular metabolic process|cellular response to stress|defense response to other organism|intracellular membrane-bounded organelle|chaperone binding|translational initiation|enzyme binding|negative regulation of response to endoplasmic reticulum stress|cytoplasm|response to virus|negative regulation of cell death|misfolded protein binding|cell communication|negative regulation of molecular function|signal transduction|endoplasmic reticulum|extracellular exosome|response to cold|cell death|defense response to virus|regulation of catalytic activity|regulation of translational initiation by eIF2 alpha phosphorylation|kinase regulator activity|negative regulation of catalytic activity|endoplasmic reticulum Sec complex|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|eiF2alpha phosphorylation in response to endoplasmic reticulum stress|regulation of cellular protein metabolic process|cytosol|cellular response to cold|kinase inhibitor activity|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of translation in response to stress|peptide metabolic process|endoplasmic reticulum unfolded protein response|macromolecule modification|protein catabolic process|protein kinase regulator activity|negative regulation of programmed cell death|regulation of translational initiation|cellular macromolecule catabolic process|smooth endoplasmic reticulum|positive regulation of gene expression|negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation|protein modification process|negative regulation of cellular protein metabolic process|rough endoplasmic reticulum|response to unfolded protein|positive regulation of protein metabolic process|proteolysis|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|cellular amide metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of translational initiation|gene expression|endoplasmic reticulum lumen|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|cellular response to unfolded protein|cellular protein catabolic process|peptide biosynthetic process|IRE1-mediated unfolded protein response|positive regulation of translational initiation in response to stress|positive regulation of translation|phosphorylation|posttranscriptional regulation of gene expression|negative regulation of cyclin-dependent protein kinase activity|translation|proteolysis involved in cellular protein catabolic process|regulation of translation|regulation of translational initiation in response to stress|protein kinase inhibitor activity|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of kinase activity|protein kinase binding|cellular protein modification process|regulation of kinase activity|apoptotic process|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|positive regulation of translation in response to endoplasmic reticulum stress|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|positive regulation of translation initiation in response to endoplasmic reticulum stress|negative regulation of protein phosphorylation K09523 DnaJ homolog subfamily C member 3[-] hsa05164|hsa04141 Influenza A - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human) 13:95677139-95794989 457 450 604 1122 1139 1049 4.7948278164731 4.29091468182987 5.71357789687168 10.5474553917269 9.80502501279312 10.3148162234168 4.93310679839155 10.2224322093123 -1.05117006943011 3.28005372687228e-07 4.53555923863109e-06 DOWN ENSG00000019582 CD74 CD74 molecule, major histocompatibility complex, class II invariant chain [Source:HGNC Symbol;Acc:HGNC:1697] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0002683|GO:0033218|GO:0004872|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0019882|GO:0040012|GO:0043229|GO:0006950|GO:0048520|GO:0042175|GO:0071704|GO:0050900|GO:0006955|GO:0003823|GO:0009986|GO:0051051|GO:0044237|GO:0051641|GO:0050795|GO:0038023|GO:0001776|GO:0048870|GO:0023051|GO:0040017|GO:0016043|GO:0006457|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0045058|GO:0031090|GO:0019222|GO:0042802|GO:0008284|GO:0051272|GO:0042127|GO:0002250|GO:1903706|GO:0044255|GO:0016337|GO:0042277|GO:0006935|GO:0045595|GO:0009897|GO:0070661|GO:0002685|GO:0060760|GO:0044183|GO:0019884|GO:0050867|GO:0006810|GO:0010941|GO:0061077|GO:0006082|GO:0098797|GO:0007275|GO:0045596|GO:0048513|GO:0002906|GO:0070489|GO:0035693|GO:0005102|GO:0044281|GO:0006952|GO:0030155|GO:0031982|GO:0031325|GO:0042092|GO:0043368|GO:2000147|GO:0033554|GO:0022607|GO:0001817|GO:0098609|GO:0045597|GO:0043231|GO:0031227|GO:0043383|GO:0030133|GO:0019899|GO:0004888|GO:0005774|GO:0048144|GO:0005737|GO:0001816|GO:0050920|GO:0012506|GO:0043235|GO:0006928|GO:0032403|GO:0042592|GO:0002687|GO:0002696|GO:0001775|GO:0030666|GO:0009966|GO:0002367|GO:0045184|GO:0030658|GO:0001819|GO:0060548|GO:0010646|GO:0043085|GO:0007162|GO:0050776|GO:0030176|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0050778|GO:0005783|GO:0006458|GO:0002260|GO:0009968|GO:0070062|GO:0051649|GO:0045785|GO:0019955|GO:0002504|GO:0008219|GO:0002695|GO:0019883|GO:0030595|GO:0050790|GO:0051048|GO:0048002|GO:0045061|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031301|GO:0010033|GO:0031323|GO:0005794|GO:0005768|GO:0050921|GO:0002443|GO:0000165|GO:1902533|GO:0043518|GO:0051249|GO:0032268|GO:0012507|GO:1902230|GO:0042113|GO:0032943|GO:0005802|GO:0045059|GO:0002688|GO:0007166|GO:0001959|GO:0043412|GO:0030097|GO:0004896|GO:0034097|GO:0030098|GO:0031410|GO:0032642|GO:0043069|GO:0071556|GO:0002606|GO:2001234|GO:0002690|GO:0006631|GO:0034109|GO:0050998|GO:0015031|GO:0045060|GO:0005773|GO:0030334|GO:0016023|GO:0051347|GO:0002718|GO:0036211|GO:0001961|GO:0030665|GO:0035692|GO:0046907|GO:0042886|GO:0048872|GO:0023026|GO:0032602|GO:0001782|GO:0002828|GO:0051251|GO:0051250|GO:0002720|GO:0048145|GO:0022408|GO:0022407|GO:0051046|GO:0042287|GO:0005770|GO:0060326|GO:2001020|GO:1902622|GO:0007159|GO:0051247|GO:0048146|GO:0031988|GO:0006461|GO:0042116|GO:0034613|GO:0002460|GO:0032270|GO:0042110|GO:0030669|GO:0012501|GO:0006796|GO:0035556|GO:0043030|GO:0030659|GO:0002792|GO:0044267|GO:0051174|GO:0051084|GO:0002830|GO:0008610|GO:0005775|GO:0035718|GO:0046903|GO:0071310|GO:0000139|GO:1902532|GO:0051246|GO:0005771|GO:0046651|GO:0030154|GO:0022409|GO:0030335|GO:1902531|GO:0043067|GO:0051085|GO:0006690|GO:0006974|GO:0030134|GO:0032722|GO:0097190|GO:0002495|GO:0071621|GO:0001540|GO:0002521|GO:1903038|GO:0002790|GO:0033559|GO:0090023|GO:0097193|GO:0010934|GO:0019221|GO:2001242|GO:0042658|GO:0031401|GO:0050863|GO:0042613|GO:1990266|GO:1901797|GO:0030139|GO:0043408|GO:0000323|GO:0045620|GO:0072331|GO:0042770|GO:0050868|GO:2001243|GO:0071622|GO:0030217|GO:2000341|GO:0016310|GO:0015833|GO:0045619|GO:0034112|GO:0070371|GO:0050871|GO:0043202|GO:0030593|GO:0070486|GO:1902166|GO:0006886|GO:0071624|GO:0030135|GO:0019886|GO:0006633|GO:0008630|GO:0050864|GO:0043410|GO:1901796|GO:2000343|GO:0042981|GO:0071345|GO:0033077|GO:0043066|GO:0019752|GO:0042100|GO:0034111|GO:0019724|GO:0042289|GO:0006464|GO:0050870|GO:0046456|GO:0045621|GO:0050671|GO:0043549|GO:0032588|GO:0090022|GO:0005765|GO:0006915|GO:0043516|GO:0061081|GO:1903039|GO:0033674|GO:0032946|GO:0006636|GO:2000107|GO:0045582|GO:0030136|GO:0016064|GO:0030890|GO:0072332|GO:0045859|GO:0045860|GO:0043406|GO:0005764|GO:0006468|GO:0042771|GO:0045580|GO:0045581|GO:0043405|GO:0042325|GO:0035691|GO:0070374|GO:0001932|GO:0018193|GO:0032787|GO:0030888|GO:0001934|GO:0060907|GO:0070372|GO:1902165|GO:0045334|GO:1902254|GO:0071593|GO:1902253|GO:0042327|GO:0030330|GO:0006693|GO:0050731|GO:0050730|GO:0000187|GO:0071902|GO:0001516|GO:0071900|GO:0032147|GO:0070228|GO:0018108|GO:0002902|GO:0002903|GO:0001783 locomotion|developmental process|macromolecular complex|signal transducer activity|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of immune system process|amide binding|receptor activity|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|antigen processing and presentation|regulation of locomotion|intracellular organelle|response to stress|positive regulation of behavior|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|leukocyte migration|immune response|antigen binding|cell surface|negative regulation of transport|cellular metabolic process|cellular localization|regulation of behavior|signaling receptor activity|leukocyte homeostasis|cell motility|regulation of signaling|positive regulation of locomotion|cellular component organization|protein folding|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|T cell selection|organelle membrane|regulation of metabolic process|identical protein binding|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|adaptive immune response|regulation of hemopoiesis|cellular lipid metabolic process|single organismal cell-cell adhesion|peptide binding|chemotaxis|regulation of cell differentiation|external side of plasma membrane|leukocyte proliferation|regulation of leukocyte migration|positive regulation of response to cytokine stimulus|protein binding involved in protein folding|antigen processing and presentation of exogenous antigen|positive regulation of cell activation|transport|regulation of cell death|chaperone-mediated protein folding|organic acid metabolic process|plasma membrane protein complex|multicellular organism development|negative regulation of cell differentiation|animal organ development|negative regulation of mature B cell apoptotic process|T cell aggregation|NOS2-CD74 complex|receptor binding|small molecule metabolic process|defense response|regulation of cell adhesion|vesicle|positive regulation of cellular metabolic process|type 2 immune response|positive T cell selection|positive regulation of cell motility|cellular response to stress|cellular component assembly|regulation of cytokine production|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|negative T cell selection|transport vesicle|enzyme binding|transmembrane signaling receptor activity|vacuolar membrane|fibroblast proliferation|cytoplasm|cytokine production|regulation of chemotaxis|vesicle membrane|receptor complex|movement of cell or subcellular component|protein complex binding|homeostatic process|positive regulation of leukocyte migration|positive regulation of leukocyte activation|cell activation|endocytic vesicle membrane|regulation of signal transduction|cytokine production involved in immune response|establishment of protein localization|transport vesicle membrane|positive regulation of cytokine production|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|negative regulation of cell adhesion|regulation of immune response|integral component of endoplasmic reticulum membrane|protein localization|lymphocyte activation|regulation of cell activation|cell communication|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|positive regulation of immune response|endoplasmic reticulum|'de novo' protein folding|lymphocyte homeostasis|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|positive regulation of cell adhesion|cytokine binding|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|cell death|negative regulation of leukocyte activation|antigen processing and presentation of endogenous antigen|leukocyte chemotaxis|regulation of catalytic activity|negative regulation of secretion|antigen processing and presentation of peptide antigen|thymic T cell selection|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|integral component of organelle membrane|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|endosome|positive regulation of chemotaxis|leukocyte mediated immunity|MAPK cascade|positive regulation of intracellular signal transduction|negative regulation of DNA damage response, signal transduction by p53 class mediator|regulation of lymphocyte activation|regulation of cellular protein metabolic process|ER to Golgi transport vesicle membrane|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|B cell activation|mononuclear cell proliferation|trans-Golgi network|positive thymic T cell selection|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|macromolecule modification|hemopoiesis|cytokine receptor activity|response to cytokine|lymphocyte differentiation|cytoplasmic vesicle|regulation of chemokine production|negative regulation of programmed cell death|integral component of lumenal side of endoplasmic reticulum membrane|positive regulation of dendritic cell antigen processing and presentation|negative regulation of apoptotic signaling pathway|positive regulation of leukocyte chemotaxis|fatty acid metabolic process|homotypic cell-cell adhesion|nitric-oxide synthase binding|protein transport|negative thymic T cell selection|vacuole|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|regulation of cytokine production involved in immune response|protein modification process|positive regulation of cytokine-mediated signaling pathway|clathrin-coated vesicle membrane|macrophage migration inhibitory factor receptor complex|intracellular transport|amide transport|homeostasis of number of cells|MHC class II protein complex binding|chemokine production|B cell homeostasis|regulation of type 2 immune response|positive regulation of lymphocyte activation|negative regulation of lymphocyte activation|positive regulation of cytokine production involved in immune response|regulation of fibroblast proliferation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of secretion|MHC protein binding|late endosome|cell chemotaxis|regulation of response to DNA damage stimulus|regulation of neutrophil migration|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|membrane-bounded vesicle|protein complex assembly|macrophage activation|cellular protein localization|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|positive regulation of cellular protein metabolic process|T cell activation|clathrin-coated endocytic vesicle membrane|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of macrophage activation|cytoplasmic vesicle membrane|negative regulation of peptide secretion|cellular protein metabolic process|regulation of phosphorus metabolic process|'de novo' posttranslational protein folding|positive regulation of type 2 immune response|lipid biosynthetic process|vacuolar lumen|macrophage migration inhibitory factor binding|secretion|cellular response to organic substance|Golgi membrane|negative regulation of intracellular signal transduction|regulation of protein metabolic process|multivesicular body|lymphocyte proliferation|cell differentiation|positive regulation of cell-cell adhesion|positive regulation of cell migration|regulation of intracellular signal transduction|regulation of programmed cell death|chaperone mediated protein folding requiring cofactor|icosanoid metabolic process|cellular response to DNA damage stimulus|ER to Golgi transport vesicle|positive regulation of chemokine production|apoptotic signaling pathway|antigen processing and presentation of peptide antigen via MHC class II|granulocyte chemotaxis|beta-amyloid binding|leukocyte differentiation|negative regulation of leukocyte cell-cell adhesion|peptide secretion|unsaturated fatty acid metabolic process|positive regulation of neutrophil chemotaxis|intrinsic apoptotic signaling pathway|macrophage cytokine production|cytokine-mediated signaling pathway|regulation of intrinsic apoptotic signaling pathway|MHC class II protein binding, via antigen binding groove|positive regulation of protein modification process|regulation of T cell activation|MHC class II protein complex|neutrophil migration|negative regulation of signal transduction by p53 class mediator|endocytic vesicle|regulation of MAPK cascade|lytic vacuole|negative regulation of lymphocyte differentiation|signal transduction by p53 class mediator|signal transduction in response to DNA damage|negative regulation of T cell activation|negative regulation of intrinsic apoptotic signaling pathway|regulation of granulocyte chemotaxis|T cell differentiation|regulation of chemokine (C-X-C motif) ligand 2 production|phosphorylation|peptide transport|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|ERK1 and ERK2 cascade|positive regulation of B cell activation|lysosomal lumen|neutrophil chemotaxis|leukocyte aggregation|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|intracellular protein transport|positive regulation of granulocyte chemotaxis|coated vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class II|fatty acid biosynthetic process|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of B cell activation|positive regulation of MAPK cascade|regulation of signal transduction by p53 class mediator|positive regulation of chemokine (C-X-C motif) ligand 2 production|regulation of apoptotic process|cellular response to cytokine stimulus|T cell differentiation in thymus|negative regulation of apoptotic process|carboxylic acid metabolic process|B cell proliferation|negative regulation of homotypic cell-cell adhesion|B cell mediated immunity|MHC class II protein binding|cellular protein modification process|positive regulation of T cell activation|icosanoid biosynthetic process|positive regulation of lymphocyte differentiation|positive regulation of lymphocyte proliferation|regulation of kinase activity|trans-Golgi network membrane|regulation of neutrophil chemotaxis|lysosomal membrane|apoptotic process|regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of myeloid leukocyte cytokine production involved in immune response|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|positive regulation of mononuclear cell proliferation|unsaturated fatty acid biosynthetic process|negative regulation of leukocyte apoptotic process|positive regulation of T cell differentiation|clathrin-coated vesicle|immunoglobulin mediated immune response|positive regulation of B cell proliferation|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|lysosome|protein phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of T cell differentiation|negative regulation of T cell differentiation|regulation of MAP kinase activity|regulation of phosphorylation|macrophage migration inhibitory factor signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|monocarboxylic acid metabolic process|regulation of B cell proliferation|positive regulation of protein phosphorylation|positive regulation of macrophage cytokine production|regulation of ERK1 and ERK2 cascade|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|clathrin-coated endocytic vesicle|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|lymphocyte aggregation|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|positive regulation of phosphorylation|DNA damage response, signal transduction by p53 class mediator|prostaglandin metabolic process|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|prostaglandin biosynthetic process|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|regulation of lymphocyte apoptotic process|peptidyl-tyrosine phosphorylation|regulation of B cell apoptotic process|negative regulation of B cell apoptotic process|B cell apoptotic process K06505 CD74 antigen[-] hsa05168|hsa05152|hsa04612 Herpes simplex infection - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Antigen processing and presentation - Homo sapiens (human) 5:150401637-150412929 15 33 15 4 1 1 0.163816052909823 0.327545374906155 0.147697607808219 0.0391421044352847 0.00896452487021035 0.01023401966616 0.213019678541399 0.0194468829905517 3.45337587229296 3.28337863573759e-07 4.53754642629733e-06 UP ENSG00000106245 BUD31 BUD31 homolog [Source:HGNC Symbol;Acc:HGNC:29629] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0000989|GO:0000785|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0030529|GO:0009966|GO:0010646|GO:0006139|GO:0000790|GO:0007154|GO:0007165|GO:0009725|GO:0009967|GO:0044249|GO:0010469|GO:0010033|GO:0031323|GO:0051090|GO:0003713|GO:0010468|GO:0034645|GO:0033993|GO:0051427|GO:0051252|GO:0010628|GO:0051091|GO:0031981|GO:0005681|GO:0033143|GO:0005694|GO:0000228|GO:0014070|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0009755|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:2000273|GO:0043401|GO:0045893|GO:0006396|GO:0032774|GO:2001141|GO:0035257|GO:0071383|GO:0071407|GO:0030518|GO:0016071|GO:0030374|GO:0060765|GO:2000825|GO:0071396|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0006397|GO:0030521|GO:0008380|GO:0000375|GO:0000398 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|chromatin|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|nuclear chromatin|cell communication|signal transduction|response to hormone|positive regulation of signal transduction|cellular biosynthetic process|regulation of receptor activity|response to organic substance|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|hormone receptor binding|regulation of RNA metabolic process|positive regulation of gene expression|positive regulation of sequence-specific DNA binding transcription factor activity|nuclear lumen|spliceosomal complex|regulation of intracellular steroid hormone receptor signaling pathway|chromosome|nuclear chromosome|response to organic cyclic compound|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|positive regulation of receptor activity|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|RNA processing|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|mRNA metabolic process|ligand-dependent nuclear receptor transcription coactivator activity|regulation of androgen receptor signaling pathway|positive regulation of androgen receptor activity|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|mRNA processing|androgen receptor signaling pathway|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome K12873 bud site selection protein 31[-] hsa03040 Spliceosome - Homo sapiens (human) 7:99408641-99419616 2523 2347 1775 1111 1216 729 38.4134944182753 32.4757879793761 24.3657064124893 15.1557733132246 15.1903635720473 10.40214653915 31.7516629367136 13.582761141474 1.22505536798579 3.28453065827981e-07 4.53754642629733e-06 UP ENSG00000144645 OSBPL10 oxysterol binding protein like 10 [Source:HGNC Symbol;Acc:HGNC:16395] GO:0005623|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0072341|GO:0008289|GO:0005622|GO:0006810|GO:0005496|GO:0043168|GO:0005543|GO:0043178|GO:0005737|GO:0043177|GO:0001786|GO:0006629|GO:0010876|GO:0032934|GO:0006869|GO:0031406|GO:0005856|GO:0016597|GO:0015485 cell|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|modified amino acid binding|lipid binding|intracellular|transport|steroid binding|anion binding|phospholipid binding|alcohol binding|cytoplasm|organic acid binding|phosphatidylserine binding|lipid metabolic process|lipid localization|sterol binding|lipid transport|carboxylic acid binding|cytoskeleton|amino acid binding|cholesterol binding - - - - 3:31657890-32077580 126 130 295 589 544 529 0.456272473490436 0.427836043323387 0.963142455532787 1.9110306071614 1.61629657463338 1.79530722552154 0.615750324115537 1.77421146910544 -1.52676058815726 3.30089618805941e-07 4.55804601287353e-06 DOWN ENSG00000057663 ATG5 autophagy related 5 [Source:HGNC Symbol;Acc:HGNC:589] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0019882|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0051641|GO:0006914|GO:0009653|GO:0044232|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0045058|GO:0005929|GO:0048646|GO:0031090|GO:0019222|GO:0016032|GO:0007507|GO:0060341|GO:0001818|GO:0051282|GO:0016337|GO:0010506|GO:0045087|GO:0006725|GO:0009888|GO:0048468|GO:1902115|GO:0006810|GO:0051130|GO:1901360|GO:0048839|GO:0010941|GO:0005930|GO:0009991|GO:0007275|GO:0016570|GO:0048513|GO:0070489|GO:0034641|GO:0032940|GO:0006952|GO:0031982|GO:0002374|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0001817|GO:0098609|GO:0061061|GO:0043231|GO:0043383|GO:0009620|GO:0005737|GO:0001816|GO:0010508|GO:0031668|GO:0007423|GO:0032880|GO:0012506|GO:0048840|GO:0042592|GO:0070255|GO:0072593|GO:0001775|GO:0030666|GO:0070257|GO:0002367|GO:0045184|GO:0048771|GO:0019725|GO:0034274|GO:0060548|GO:0042493|GO:0010646|GO:0006139|GO:0019776|GO:0050776|GO:0008104|GO:0046649|GO:0007154|GO:0055085|GO:0060491|GO:0000422|GO:0051649|GO:2000021|GO:0008219|GO:0044233|GO:0034045|GO:0044804|GO:0016236|GO:0019883|GO:0051047|GO:0030030|GO:0045061|GO:0051238|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0050878|GO:0003013|GO:0042594|GO:0006996|GO:0051276|GO:0032268|GO:0000902|GO:0005829|GO:0031344|GO:0035150|GO:0034645|GO:1903008|GO:0032479|GO:0000423|GO:0043412|GO:0007589|GO:0030097|GO:0072358|GO:0030098|GO:0031410|GO:0043583|GO:0007005|GO:0042692|GO:0043069|GO:0031056|GO:0048878|GO:0006325|GO:0035051|GO:0032386|GO:0048738|GO:0051223|GO:0015031|GO:1903146|GO:0045060|GO:0055006|GO:0005773|GO:1902017|GO:0051208|GO:0016573|GO:0016023|GO:0002718|GO:0036211|GO:0044782|GO:0032269|GO:2000377|GO:0070201|GO:0060537|GO:0046907|GO:0006811|GO:0016239|GO:0051209|GO:0055082|GO:0016241|GO:0051279|GO:0051046|GO:0042157|GO:0030031|GO:0032480|GO:0007159|GO:0009306|GO:0032606|GO:0070254|GO:0031988|GO:0034765|GO:0022604|GO:2000378|GO:0009267|GO:0001974|GO:0055001|GO:0043269|GO:0002739|GO:0050663|GO:0070925|GO:1903599|GO:0039689|GO:0042110|GO:0012501|GO:0042384|GO:0030659|GO:0033043|GO:0044267|GO:0032990|GO:0019079|GO:0046903|GO:0019058|GO:0051246|GO:0009059|GO:0010522|GO:0030154|GO:0000407|GO:0048858|GO:0050707|GO:0031669|GO:0000045|GO:0016070|GO:0072359|GO:0031667|GO:0008015|GO:0030670|GO:0043067|GO:0007033|GO:0034220|GO:0010638|GO:0060271|GO:0055002|GO:0002521|GO:0006995|GO:0098655|GO:0061739|GO:2001251|GO:0030139|GO:0055013|GO:0032774|GO:0035067|GO:0060047|GO:0006812|GO:0043967|GO:0030217|GO:0050708|GO:0033044|GO:0060402|GO:0010822|GO:0070486|GO:0016482|GO:0005776|GO:0010821|GO:0042158|GO:0051146|GO:0042981|GO:0035065|GO:0033077|GO:0050801|GO:0043066|GO:0016568|GO:0014706|GO:0055007|GO:0006464|GO:0006915|GO:0006873|GO:0090279|GO:0050880|GO:1903169|GO:0090239|GO:0042311|GO:0045335|GO:0055015|GO:1901984|GO:0018193|GO:0043984|GO:0030001|GO:0043687|GO:0055012|GO:0051924|GO:0006497|GO:0071593|GO:0090241|GO:0030003|GO:0032446|GO:0070588|GO:0055065|GO:0031396|GO:0031397|GO:0097553|GO:0006875|GO:2000619|GO:2000757|GO:0006473|GO:0006501|GO:0018205|GO:0018394|GO:0006874|GO:0006816|GO:0055074|GO:0016567|GO:0006475|GO:0018393|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|macromolecular complex|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|antigen processing and presentation|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|cellular localization|autophagy|anatomical structure morphogenesis|organelle membrane contact site|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|T cell selection|cilium|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|viral process|heart development|regulation of cellular localization|negative regulation of cytokine production|regulation of sequestering of calcium ion|single organismal cell-cell adhesion|regulation of autophagy|innate immune response|cellular aromatic compound metabolic process|tissue development|cell development|regulation of organelle assembly|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|inner ear development|regulation of cell death|axoneme|response to extracellular stimulus|multicellular organism development|histone modification|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|secretion by cell|defense response|vesicle|cytokine secretion involved in immune response|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|regulation of cytokine production|cell-cell adhesion|muscle structure development|intracellular membrane-bounded organelle|negative T cell selection|response to fungus|cytoplasm|cytokine production|positive regulation of autophagy|cellular response to extracellular stimulus|sensory organ development|regulation of protein localization|vesicle membrane|otolith development|homeostatic process|regulation of mucus secretion|reactive oxygen species metabolic process|cell activation|endocytic vesicle membrane|positive regulation of mucus secretion|cytokine production involved in immune response|establishment of protein localization|tissue remodeling|cellular homeostasis|Atg12-Atg5-Atg16 complex|negative regulation of cell death|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|Atg8 ligase activity|regulation of immune response|protein localization|lymphocyte activation|cell communication|transmembrane transport|regulation of cell projection assembly|mitophagy|establishment of localization in cell|regulation of ion homeostasis|cell death|ER-mitochondrion membrane contact site|pre-autophagosomal structure membrane|nucleophagy|macroautophagy|antigen processing and presentation of endogenous antigen|positive regulation of secretion|cell projection organization|thymic T cell selection|sequestering of metal ion|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|response to starvation|organelle organization|chromosome organization|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|regulation of cell projection organization|regulation of tube size|cellular macromolecule biosynthetic process|organelle disassembly|regulation of type I interferon production|macromitophagy|macromolecule modification|body fluid secretion|hemopoiesis|cardiovascular system development|lymphocyte differentiation|cytoplasmic vesicle|ear development|mitochondrion organization|muscle cell differentiation|negative regulation of programmed cell death|regulation of histone modification|chemical homeostasis|chromatin organization|cardiocyte differentiation|regulation of intracellular transport|cardiac muscle tissue development|regulation of protein transport|protein transport|regulation of mitophagy|negative thymic T cell selection|cardiac cell development|vacuole|regulation of cilium assembly|sequestering of calcium ion|histone acetylation|cytoplasmic, membrane-bounded vesicle|regulation of cytokine production involved in immune response|protein modification process|cilium organization|negative regulation of cellular protein metabolic process|regulation of reactive oxygen species metabolic process|regulation of establishment of protein localization|muscle tissue development|intracellular transport|ion transport|positive regulation of macroautophagy|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|regulation of macroautophagy|regulation of release of sequestered calcium ion into cytosol|regulation of secretion|lipoprotein metabolic process|cell projection assembly|negative regulation of type I interferon production|leukocyte cell-cell adhesion|protein secretion|type I interferon production|mucus secretion|membrane-bounded vesicle|regulation of ion transmembrane transport|regulation of cell morphogenesis|negative regulation of reactive oxygen species metabolic process|cellular response to starvation|blood vessel remodeling|muscle cell development|regulation of ion transport|regulation of cytokine secretion involved in immune response|cytokine secretion|organelle assembly|positive regulation of mitophagy|negative stranded viral RNA replication|T cell activation|programmed cell death|cilium assembly|cytoplasmic vesicle membrane|regulation of organelle organization|cellular protein metabolic process|cell part morphogenesis|viral genome replication|secretion|viral life cycle|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|cell differentiation|pre-autophagosomal structure|cell projection morphogenesis|regulation of cytokine secretion|cellular response to nutrient levels|autophagosome assembly|RNA metabolic process|circulatory system development|response to nutrient levels|blood circulation|phagocytic vesicle membrane|regulation of programmed cell death|vacuole organization|ion transmembrane transport|positive regulation of organelle organization|cilium morphogenesis|striated muscle cell development|leukocyte differentiation|cellular response to nitrogen starvation|cation transmembrane transport|protein lipidation involved in autophagosome assembly|negative regulation of chromosome organization|endocytic vesicle|cardiac muscle cell development|RNA biosynthetic process|negative regulation of histone acetylation|heart contraction|cation transport|histone H4 acetylation|T cell differentiation|regulation of protein secretion|regulation of chromosome organization|calcium ion transport into cytosol|positive regulation of mitochondrion organization|leukocyte aggregation|cytosolic transport|autophagosome|regulation of mitochondrion organization|lipoprotein biosynthetic process|striated muscle cell differentiation|regulation of apoptotic process|regulation of histone acetylation|T cell differentiation in thymus|ion homeostasis|negative regulation of apoptotic process|chromatin modification|striated muscle tissue development|cardiac muscle cell differentiation|cellular protein modification process|apoptotic process|cellular ion homeostasis|regulation of calcium ion import|regulation of blood vessel size|regulation of calcium ion transmembrane transport|regulation of histone H4 acetylation|vasodilation|phagocytic vesicle|ventricular cardiac muscle cell development|negative regulation of protein acetylation|peptidyl-amino acid modification|histone H4-K16 acetylation|metal ion transport|post-translational protein modification|ventricular cardiac muscle cell differentiation|regulation of calcium ion transport|protein lipidation|lymphocyte aggregation|negative regulation of histone H4 acetylation|cellular cation homeostasis|protein modification by small protein conjugation|calcium ion transmembrane transport|metal ion homeostasis|regulation of protein ubiquitination|negative regulation of protein ubiquitination|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|negative regulation of histone H4-K16 acetylation|negative regulation of peptidyl-lysine acetylation|protein acetylation|C-terminal protein lipidation|peptidyl-lysine modification|peptidyl-lysine acetylation|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|protein ubiquitination|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K08339 autophagy-related protein 5[-] hsa04211|hsa04622|hsa05131|hsa04213|hsa04140 Longevity regulating pathway - mammal - Homo sapiens (human)|RIG-I-like receptor signaling pathway - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Regulation of autophagy - Homo sapiens (human) 6:106184476-106325820 226 254 414 727 792 674 2.31890253796391 2.36857770932458 3.82991674544561 6.68353770655261 6.66757424816085 6.48132197920135 2.83913233091137 6.61081131130494 -1.21937724312176 3.30631062742276e-07 4.56341181096066e-06 DOWN ENSG00000089234 BRAP BRCA1 associated protein [Source:HGNC Symbol;Acc:HGNC:1099] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0033218|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0016874|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0032182|GO:0042277|GO:0006935|GO:0045087|GO:0048468|GO:0007275|GO:0006952|GO:0031325|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0005635|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0019787|GO:0031965|GO:0050790|GO:0000166|GO:0030030|GO:0000151|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0046872|GO:0007166|GO:0043412|GO:0004842|GO:0043130|GO:1901652|GO:0000904|GO:0071417|GO:0005048|GO:0051347|GO:0036211|GO:0043434|GO:1990234|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0005634|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:0061630|GO:1901653|GO:0043408|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0007167|GO:0071375|GO:0043410|GO:0046914|GO:0032868|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0008139|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0008270|GO:0042327|GO:0007169|GO:0032446|GO:0048010|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0016567 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|amide binding|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|ligase activity|intracellular|regulation of immune system process|protein binding|protein complex|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|ubiquitin-like protein binding|peptide binding|chemotaxis|innate immune response|cell development|multicellular organism development|defense response|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|nuclear envelope|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|ubiquitin-like protein transferase activity|nuclear membrane|regulation of catalytic activity|nucleotide binding|cell projection organization|ubiquitin ligase complex|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|ubiquitin-protein transferase activity|ubiquitin binding|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|signal sequence binding|positive regulation of transferase activity|protein modification process|response to peptide hormone|transferase complex|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|nucleus|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|ubiquitin protein ligase activity|cellular response to peptide|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|transition metal ion binding|response to insulin|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|nuclear localization sequence binding|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|zinc ion binding|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|protein ubiquitination K10632 BRCA1-associated protein[2.3.2.27] hsa04014 Ras signaling pathway - Homo sapiens (human) 12:111642146-111685986 844 813 573 335 384 344 10.8253690096292 9.47700233259422 6.62626581015188 3.84983649389866 4.04109360806318 4.13512014446083 8.9762123841251 4.00868341547422 1.16297832603524 3.31652526792063e-07 4.57539488671453e-06 UP ENSG00000111845 PAK1IP1 PAK1 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:20882] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0071944|GO:0023057|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0043231|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0060021|GO:0005730|GO:0031981|GO:0005654|GO:0005634 developmental process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|cell periphery|negative regulation of signaling|intracellular|protein binding|plasma membrane|anatomical structure development|intracellular membrane-bounded organelle|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|palate development|nucleolus|nuclear lumen|nucleoplasm|nucleus - - - - 6:10694695-10709782 1679 1647 956 610 712 382 65.9817694328901 58.8229659152871 33.8723420824269 21.4783542921824 22.9573193255202 14.0690711044758 52.8923591435347 19.5015815740595 1.43946819397334 3.32014985077491e-07 4.57827961408933e-06 UP ENSG00000154001 PPP2R5E protein phosphatase 2 regulatory subunit B', epsilon [Source:HGNC Symbol;Acc:HGNC:9313] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0044237|GO:0008287|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0019208|GO:0005737|GO:0000159|GO:0007154|GO:0007165|GO:0050790|GO:0019538|GO:0031323|GO:0032268|GO:0043412|GO:0036211|GO:0006796|GO:0044267|GO:0051174|GO:0019888|GO:0051246|GO:0016311|GO:0008601|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0043666|GO:0035303|GO:0034047 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cellular metabolic process|protein serine/threonine phosphatase complex|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|phosphatase regulator activity|cytoplasm|protein phosphatase type 2A complex|cell communication|signal transduction|regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|protein phosphatase regulator activity|regulation of protein metabolic process|dephosphorylation|protein phosphatase type 2A regulator activity|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|regulation of dephosphorylation|regulation of protein phosphatase type 2A activity K11584 serine/threonine-protein phosphatase 2A regulatory subunit B'[-] hsa04151|hsa04261|hsa04728|hsa04152|hsa04114|hsa04071|hsa03015 PI3K-Akt signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|AMPK signaling pathway - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|mRNA surveillance pathway - Homo sapiens (human) 14:63371357-63543374 795 940 1292 2115 2529 2158 3.99941681610644 4.29771174195584 5.86011714902455 9.53317565816842 10.4386992596892 10.1744271599792 4.71908190236228 10.0487673592789 -1.09044042722373 3.35703730094967e-07 4.6270079216321e-06 DOWN ENSG00000111261 MANSC1 MANSC domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25505] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 12:12326056-12350541 391 430 457 873 957 996 2.79177502788292 2.79030995693102 2.94194026006158 5.58489884309189 5.60638989412697 6.66487568110978 2.84134174829184 5.95205480610955 -1.06681544563127 3.36675627531976e-07 4.63612277875444e-06 DOWN ENSG00000100890 KIAA0391 KIAA0391 [Source:HGNC Symbol;Acc:HGNC:19958] GO:0005623|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0005739|GO:0010467|GO:0016070|GO:0006396|GO:0034660|GO:0006399|GO:0008033 cell|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|mitochondrion|gene expression|RNA metabolic process|RNA processing|ncRNA metabolic process|tRNA metabolic process|tRNA processing - - - - 14:35121846-35277614 361 484 525 1022 1047 955 2.10519173873811 2.56513726756681 2.76031131042862 5.33990530461464 5.00956195815731 5.21936151925113 2.47688010557785 5.18960959400769 -1.06710197502033 3.37196291430854e-07 4.64115172170434e-06 DOWN ENSG00000197077 KIAA1671 KIAA1671 [Source:HGNC Symbol;Acc:HGNC:29345] - - - - - - 22:24952730-25197448 491 423 686 1174 1365 1202 1.31874559747872 1.03252303618879 1.66118422552804 2.82517448267282 3.00801428325623 3.02560957294203 1.33748428639852 2.95293277962369 -1.14262657349622 3.4268783750383e-07 4.71456345660799e-06 DOWN ENSG00000173110 HSPA6 heat shock protein family A (Hsp70) member 6 [Source:HGNC Symbol;Acc:HGNC:5239] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0043229|GO:0006950|GO:0043167|GO:0009628|GO:0006457|GO:0043227|GO:0016787|GO:0005615|GO:0005622|GO:0072562|GO:0005515|GO:0043234|GO:0043168|GO:0001882|GO:0031982|GO:0033554|GO:0016817|GO:0043231|GO:0042026|GO:0019899|GO:0005737|GO:0009408|GO:0070062|GO:0051082|GO:0031072|GO:0000166|GO:0009266|GO:0010033|GO:0008180|GO:0005829|GO:0005813|GO:0035639|GO:0005815|GO:0001883|GO:0016818|GO:0005814|GO:0032549|GO:0006986|GO:0034605|GO:0017076|GO:0005856|GO:0005634|GO:0005524|GO:0030554|GO:0015630|GO:0016462|GO:0017111|GO:0016887|GO:0042623 macromolecular complex|cell|cellular process|extracellular region|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|response to stress|ion binding|response to abiotic stimulus|protein folding|membrane-bounded organelle|hydrolase activity|extracellular space|intracellular|blood microparticle|protein binding|protein complex|anion binding|nucleoside binding|vesicle|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|protein refolding|enzyme binding|cytoplasm|response to heat|extracellular exosome|unfolded protein binding|heat shock protein binding|nucleotide binding|response to temperature stimulus|response to organic substance|COP9 signalosome|cytosol|centrosome|purine ribonucleoside triphosphate binding|microtubule organizing center|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|centriole|ribonucleoside binding|response to unfolded protein|cellular response to heat|purine nucleotide binding|cytoskeleton|nucleus|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|ATPase activity, coupled K03283 heat shock 70kDa protein 1/8[-] hsa04144|hsa04010|hsa05169|hsa05164|hsa04141|hsa05162|hsa03040|hsa05145|hsa04915|hsa04612|hsa04213|hsa05134 Endocytosis - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|Measles - Homo sapiens (human)|Spliceosome - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Antigen processing and presentation - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Legionellosis - Homo sapiens (human) 1:161524540-161526910 45 42 26 12 4 5 1.34254575497245 1.138788143113 0.699351583112954 0.320780359039231 0.0979066502064712 0.139814105288483 1.0602284937328 0.186167038178062 2.50970565468111 3.44958508275029e-07 4.74361644681838e-06 UP ENSG00000272486 RP11-532M24.1 - - - - - - - 8:124579631-124580648 64 57 30 6 10 15 4.44709902900713 3.59961359839374 1.87944480505665 0.373561017329085 0.570137318710994 0.976844021774632 3.30871914415251 0.640180785938237 2.36972155343411 3.47311035931324e-07 4.77376780234519e-06 UP ENSG00000180530 NRIP1 nuclear receptor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8001] GO:0032502|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0007623|GO:0044702|GO:0071704|GO:0042698|GO:0019953|GO:0044237|GO:0003006|GO:0000989|GO:0000785|GO:0043227|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0022602|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0001542|GO:0032922|GO:0043231|GO:0048608|GO:0019899|GO:0030728|GO:0007548|GO:0009890|GO:0006139|GO:0000790|GO:0008406|GO:0007154|GO:0007276|GO:0007165|GO:0008134|GO:0009725|GO:0019915|GO:0001543|GO:0044249|GO:0010876|GO:0010033|GO:0031324|GO:0031323|GO:0003713|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0033993|GO:0008585|GO:0061458|GO:0010629|GO:0051427|GO:0051252|GO:0042974|GO:0046545|GO:0010628|GO:0031981|GO:0042826|GO:0005654|GO:0005694|GO:0000228|GO:0014070|GO:0010467|GO:0000118|GO:0071310|GO:0031328|GO:0009059|GO:0009755|GO:0016070|GO:0007292|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0097305|GO:0030522|GO:0043401|GO:0000975|GO:0045893|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0035257|GO:0043627|GO:1902679|GO:0071383|GO:0071407|GO:0016604|GO:0003690|GO:0030518|GO:0046965|GO:0032355|GO:0071396|GO:0006351|GO:0006355|GO:0016607|GO:0045944|GO:0006366|GO:1903507|GO:0035258|GO:0006357|GO:1903506|GO:0044212|GO:0030521|GO:0071392|GO:0071391|GO:0000122|GO:0050681|GO:0001047|GO:0000976|GO:0035259|GO:0030331|GO:0001046 developmental process|macromolecular complex|reproduction|signaling|cell|rhythmic process|cellular process|reproductive process|metabolic process|cell junction|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|circadian rhythm|single organism reproductive process|organic substance metabolic process|ovulation cycle|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|transcription factor activity, transcription factor binding|chromatin|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|ovulation cycle process|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|ovulation from ovarian follicle|circadian regulation of gene expression|intracellular membrane-bounded organelle|reproductive structure development|enzyme binding|ovulation|sex differentiation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|nuclear chromatin|gonad development|cell communication|gamete generation|signal transduction|transcription factor binding|response to hormone|lipid storage|ovarian follicle rupture|cellular biosynthetic process|lipid localization|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription coactivator activity|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|response to lipid|female gonad development|reproductive system development|negative regulation of gene expression|hormone receptor binding|regulation of RNA metabolic process|retinoic acid receptor binding|development of primary female sexual characteristics|positive regulation of gene expression|nuclear lumen|histone deacetylase binding|nucleoplasm|chromosome|nuclear chromosome|response to organic cyclic compound|gene expression|histone deacetylase complex|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|female gamete generation|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|response to alcohol|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nuclear hormone receptor binding|response to estrogen|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|nuclear body|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|retinoid X receptor binding|response to estradiol|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|androgen receptor signaling pathway|cellular response to estradiol stimulus|cellular response to estrogen stimulus|negative regulation of transcription from RNA polymerase II promoter|androgen receptor binding|core promoter binding|transcription regulatory region sequence-specific DNA binding|glucocorticoid receptor binding|estrogen receptor binding|core promoter sequence-specific DNA binding - - - - 21:14961235-15065000 644 796 929 1631 1880 1698 5.22294598589578 5.86708934926107 6.79296511334946 11.8517170556284 12.5099439858516 12.906133799753 5.9610001495021 12.422598280411 -1.0593406410975 3.47506930804732e-07 4.77426226978576e-06 DOWN ENSG00000221923 ZNF880 zinc finger protein 880 [Source:HGNC Symbol;Acc:HGNC:37249] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:52369917-52385795 110 133 131 54 58 37 1.72413543741251 1.89458045671928 1.85124998722167 0.758350942686679 0.745892791085555 0.543508674047679 1.82332196045115 0.682584135939971 1.41749054357901 3.48816646638545e-07 4.79005159555985e-06 UP ENSG00000117151 CTBS chitobiase, di-N-acetyl- [Source:HGNC Symbol;Acc:HGNC:2496] GO:0005623|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043227|GO:0016787|GO:0005615|GO:0005622|GO:0016798|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0008061|GO:0070062|GO:0009311|GO:0005773|GO:0006040|GO:0016052|GO:0004553|GO:0000323|GO:0009313|GO:0006030|GO:0004568|GO:0006032|GO:0005764 cell|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|membrane-bounded organelle|hydrolase activity|extracellular space|intracellular|hydrolase activity, acting on glycosyl bonds|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|chitin binding|extracellular exosome|oligosaccharide metabolic process|vacuole|amino sugar metabolic process|carbohydrate catabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|lytic vacuole|oligosaccharide catabolic process|chitin metabolic process|chitinase activity|chitin catabolic process|lysosome - - - - 1:84549606-84574480 142 116 218 363 466 560 0.91723402111969 0.680972243737746 1.26959013729475 2.10085362237517 2.46970885427565 3.39007136490263 0.955932134050729 2.65354461385115 -1.47294070137659 3.49407382864643e-07 4.79595770484647e-06 DOWN ENSG00000104980 TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) [Source:HGNC Symbol;Acc:HGNC:17316] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0031090|GO:0019866|GO:0008565|GO:0006810|GO:0043168|GO:0001882|GO:0043231|GO:0051087|GO:0005737|GO:0031966|GO:0045184|GO:0022891|GO:0008104|GO:0055085|GO:0051649|GO:0000166|GO:0019538|GO:0006996|GO:0005740|GO:0035639|GO:0072594|GO:0007005|GO:0001883|GO:0015031|GO:0046907|GO:0008320|GO:0032549|GO:0005743|GO:0005759|GO:0005739|GO:0034613|GO:0044267|GO:0017038|GO:0017076|GO:0006626|GO:0030150|GO:0071806|GO:0033365|GO:0005524|GO:0006839|GO:0030554|GO:0006605|GO:0072655|GO:0006886|GO:0065002|GO:0015450|GO:0070585 transporter activity|cell|membrane|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|organelle membrane|organelle inner membrane|protein transporter activity|transport|anion binding|nucleoside binding|intracellular membrane-bounded organelle|chaperone binding|cytoplasm|mitochondrial membrane|establishment of protein localization|substrate-specific transmembrane transporter activity|protein localization|transmembrane transport|establishment of localization in cell|nucleotide binding|protein metabolic process|organelle organization|mitochondrial envelope|purine ribonucleoside triphosphate binding|establishment of protein localization to organelle|mitochondrion organization|purine nucleoside binding|protein transport|intracellular transport|protein transmembrane transporter activity|ribonucleoside binding|mitochondrial inner membrane|mitochondrial matrix|mitochondrion|cellular protein localization|cellular protein metabolic process|protein import|purine nucleotide binding|protein targeting to mitochondrion|protein import into mitochondrial matrix|protein transmembrane transport|protein localization to organelle|ATP binding|mitochondrial transport|adenyl nucleotide binding|protein targeting|establishment of protein localization to mitochondrion|intracellular protein transport|intracellular protein transmembrane transport|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein localization to mitochondrion - - - - 19:7926718-7943920 1141 1115 756 491 541 348 8.67857409327624 7.70757345076732 5.18440205277359 3.34612265370506 3.37620041385303 2.48068070733466 7.19018319893905 3.06766792496425 1.22888621004934 3.51038359558172e-07 4.81391786231037e-06 UP ENSG00000141738 GRB7 growth factor receptor bound protein 7 [Source:HGNC Symbol;Acc:HGNC:4567] GO:0040011|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0030055|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0050900|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0040017|GO:0016043|GO:0008289|GO:0071944|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0042802|GO:0035591|GO:0051272|GO:0050817|GO:0003676|GO:0034641|GO:0043168|GO:0005924|GO:0005912|GO:0005543|GO:2000147|GO:0022607|GO:0019899|GO:0005737|GO:0030529|GO:0009611|GO:0006928|GO:0009966|GO:0009890|GO:0030674|GO:0010646|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:2000145|GO:0009967|GO:0044249|GO:0022613|GO:0019538|GO:0031324|GO:0031323|GO:0050878|GO:0006996|GO:0035770|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0007166|GO:0010629|GO:0035091|GO:0007596|GO:0030334|GO:0032269|GO:0042060|GO:0022618|GO:0007599|GO:0070925|GO:0019900|GO:0043603|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0030335|GO:0005070|GO:0036464|GO:0005925|GO:0043043|GO:0034622|GO:0017148|GO:0034063|GO:0010608|GO:0006412|GO:0007167|GO:0006417|GO:0019901|GO:0010494|GO:0007169|GO:0038127|GO:0007173 locomotion|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|binding, bridging|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|leukocyte migration|ion binding|cellular metabolic process|cell motility|regulation of signaling|positive regulation of locomotion|cellular component organization|lipid binding|cell periphery|biosynthetic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|identical protein binding|signaling adaptor activity|positive regulation of cellular component movement|coagulation|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|cell-substrate adherens junction|adherens junction|phospholipid binding|positive regulation of cell motility|cellular component assembly|enzyme binding|cytoplasm|intracellular ribonucleoprotein complex|response to wounding|movement of cell or subcellular component|regulation of signal transduction|negative regulation of biosynthetic process|protein binding, bridging|regulation of cell communication|cell communication|regulation of cellular component movement|cell migration|signal transduction|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|organelle organization|ribonucleoprotein granule|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|cell surface receptor signaling pathway|negative regulation of gene expression|phosphatidylinositol binding|blood coagulation|regulation of cell migration|negative regulation of cellular protein metabolic process|wound healing|ribonucleoprotein complex assembly|hemostasis|organelle assembly|kinase binding|cellular amide metabolic process|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of cell migration|SH3/SH2 adaptor activity|cytoplasmic ribonucleoprotein granule|focal adhesion|peptide biosynthetic process|cellular macromolecular complex assembly|negative regulation of translation|stress granule assembly|posttranscriptional regulation of gene expression|translation|enzyme linked receptor protein signaling pathway|regulation of translation|protein kinase binding|cytoplasmic stress granule|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 17:39737927-39747291 783 765 1187 426 481 521 7.17447290608106 6.37045043581111 9.80603350306524 3.49732455382681 3.6161115736845 4.47399551558498 7.78365228165247 3.86247721436543 1.01092083992734 3.51830436476114e-07 4.82256466967764e-06 UP ENSG00000139998 RAB15 RAB15, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:20150] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0043167|GO:0051641|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0005929|GO:0031090|GO:0060341|GO:0006810|GO:0060627|GO:0043168|GO:0032940|GO:0001882|GO:0031982|GO:0016817|GO:0043231|GO:0005737|GO:0045184|GO:0072372|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0051649|GO:0010008|GO:0051047|GO:0000166|GO:0005768|GO:0016192|GO:0035639|GO:0001883|GO:0015031|GO:0045921|GO:0006887|GO:0016818|GO:0046907|GO:0032549|GO:0017157|GO:0051046|GO:0048471|GO:0034613|GO:0035556|GO:0046903|GO:0017076|GO:0032561|GO:0045055|GO:0051169|GO:1903307|GO:0006886|GO:1903305|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0006913|GO:0017111|GO:0003924 signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|ion binding|cellular localization|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|endomembrane system|cilium|organelle membrane|regulation of cellular localization|transport|regulation of vesicle-mediated transport|anion binding|secretion by cell|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|primary cilium|protein localization|cell communication|signal transduction|extracellular exosome|establishment of localization in cell|endosome membrane|positive regulation of secretion|nucleotide binding|endosome|vesicle-mediated transport|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|positive regulation of exocytosis|exocytosis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|regulation of exocytosis|regulation of secretion|perinuclear region of cytoplasm|cellular protein localization|intracellular signal transduction|secretion|purine nucleotide binding|guanyl ribonucleotide binding|regulated exocytosis|nuclear transport|positive regulation of regulated secretory pathway|intracellular protein transport|regulation of regulated secretory pathway|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|nucleocytoplasmic transport|nucleoside-triphosphatase activity|GTPase activity - - - - 14:64945814-64972776 1380 1335 1355 3180 3076 2885 10.1441222980299 8.91859498592241 8.98025817164051 20.9440210702751 18.5519504458882 19.8751347424508 9.34765848519761 19.7903687528714 -1.08212156266841 3.52310626018101e-07 4.8269304401764e-06 DOWN ENSG00000171914 TLN2 talin 2 [Source:HGNC Symbol;Acc:HGNC:15447] GO:0045202|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0005200|GO:0042995|GO:0030055|GO:0044877|GO:0043229|GO:0051641|GO:0005911|GO:0016043|GO:0007155|GO:0071944|GO:0031252|GO:0005622|GO:0005515|GO:0005886|GO:0005102|GO:0005924|GO:0005912|GO:0022607|GO:0051651|GO:0005737|GO:0001726|GO:0032403|GO:0008104|GO:0008092|GO:0006996|GO:0045216|GO:0007010|GO:0003779|GO:0005158|GO:0034329|GO:0007016|GO:0032507|GO:0034613|GO:0051015|GO:0005856|GO:0005925|GO:0015629|GO:0007043 synapse|structural molecule activity|cell|membrane|cellular process|cell junction|binding|structural constituent of cytoskeleton|cell projection|cell-substrate junction|macromolecular complex binding|intracellular organelle|cellular localization|cell-cell junction|cellular component organization|cell adhesion|cell periphery|cell leading edge|intracellular|protein binding|plasma membrane|receptor binding|cell-substrate adherens junction|adherens junction|cellular component assembly|maintenance of location in cell|cytoplasm|ruffle|protein complex binding|protein localization|cytoskeletal protein binding|organelle organization|cell-cell junction organization|cytoskeleton organization|actin binding|insulin receptor binding|cell junction assembly|cytoskeletal anchoring at plasma membrane|maintenance of protein location in cell|cellular protein localization|actin filament binding|cytoskeleton|focal adhesion|actin cytoskeleton|cell-cell junction assembly K06271 talin[-] hsa05166|hsa04015|hsa04510|hsa04611 HTLV-I infection - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Platelet activation - Homo sapiens (human) 15:62390526-62844631 9 19 22 51 75 88 0.0324317471730991 0.0622256324075492 0.0714748036461518 0.164662623822236 0.221746418016331 0.297190563461193 0.0553773944089334 0.22786653509992 -2.04081998389534 3.54125642820656e-07 4.84957199117791e-06 DOWN ENSG00000197362 ZNF786 zinc finger protein 786 [Source:HGNC Symbol;Acc:HGNC:21806] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 7:149069643-149090782 703 772 437 275 309 226 5.84759886586277 5.83606044853685 3.27731748175559 2.0495208541704 2.10886726060169 1.76181589929741 4.98699226538507 1.97340133802317 1.33748557324913 3.5431908197227e-07 4.84999627381941e-06 UP ENSG00000181016 LSMEM1 leucine-rich single-pass membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:22036] GO:0005623|GO:0016020|GO:0005488|GO:0031224|GO:0005622|GO:0005515|GO:0005737|GO:0016021 cell|membrane|binding|intrinsic component of membrane|intracellular|protein binding|cytoplasm|integral component of membrane - - - - 7:112480853-112491062 61 82 54 21 18 22 1.1193201694317 1.36746012204506 0.89337174045883 0.345257028699742 0.270991731706064 0.378339286267446 1.12671734397853 0.331529348891084 1.76491713975752 3.56505176729831e-07 4.8754491736566e-06 UP ENSG00000197959 DNM3 dynamin 3 [Source:HGNC Symbol;Acc:HGNC:29125] GO:0032502|GO:0045202|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042995|GO:0097159|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0043083|GO:0044089|GO:0043167|GO:0009653|GO:0016043|GO:0043227|GO:0016787|GO:0050793|GO:0044327|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0045595|GO:0048468|GO:0006810|GO:0051130|GO:0007275|GO:0045596|GO:0005102|GO:0016358|GO:0043168|GO:0005874|GO:0001882|GO:0031982|GO:0051491|GO:0051128|GO:0016817|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0001917|GO:0043005|GO:0043197|GO:0036477|GO:0014069|GO:0060996|GO:0060491|GO:0070062|GO:0050808|GO:0000166|GO:0030030|GO:0048869|GO:0005794|GO:0050768|GO:0016192|GO:0000902|GO:0060998|GO:0031175|GO:2000171|GO:0031344|GO:0007416|GO:0035639|GO:0060997|GO:0030424|GO:0044309|GO:0050773|GO:0097061|GO:0048813|GO:0001883|GO:0050998|GO:0010721|GO:0031346|GO:0000904|GO:0016818|GO:0032549|GO:0031345|GO:0030031|GO:0030425|GO:0048471|GO:0001664|GO:0022604|GO:0005739|GO:0032990|GO:0007399|GO:0061000|GO:0017076|GO:0030154|GO:0048858|GO:0005856|GO:0035254|GO:0051960|GO:0051489|GO:0048666|GO:0030182|GO:0032561|GO:0010975|GO:0010769|GO:0035256|GO:0046847|GO:0015630|GO:0048814|GO:0005525|GO:0050774|GO:0045665|GO:0006897|GO:0022008|GO:0061002|GO:0048667|GO:0050767|GO:0048812|GO:0019001|GO:0016462|GO:0010977|GO:0061001|GO:0048699|GO:0031798|GO:0017111|GO:0031802|GO:0045664|GO:0003924 developmental process|synapse|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|cell projection|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|synaptic cleft|positive regulation of cellular component biogenesis|ion binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|hydrolase activity|regulation of developmental process|dendritic spine head|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of cell differentiation|cell development|transport|positive regulation of cellular component organization|multicellular organism development|negative regulation of cell differentiation|receptor binding|dendrite development|anion binding|microtubule|nucleoside binding|vesicle|positive regulation of filopodium assembly|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|photoreceptor inner segment|neuron projection|dendritic spine|somatodendritic compartment|postsynaptic density|dendritic spine development|regulation of cell projection assembly|extracellular exosome|synapse organization|nucleotide binding|cell projection organization|cellular developmental process|Golgi apparatus|negative regulation of neurogenesis|vesicle-mediated transport|cell morphogenesis|regulation of dendritic spine development|neuron projection development|negative regulation of dendrite development|regulation of cell projection organization|synapse assembly|purine ribonucleoside triphosphate binding|dendritic spine morphogenesis|axon|neuron spine|regulation of dendrite development|dendritic spine organization|dendrite morphogenesis|purine nucleoside binding|nitric-oxide synthase binding|negative regulation of cell development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|negative regulation of cell projection organization|cell projection assembly|dendrite|perinuclear region of cytoplasm|G-protein coupled receptor binding|regulation of cell morphogenesis|mitochondrion|cell part morphogenesis|nervous system development|negative regulation of dendritic spine development|purine nucleotide binding|cell differentiation|cell projection morphogenesis|cytoskeleton|glutamate receptor binding|regulation of nervous system development|regulation of filopodium assembly|neuron development|neuron differentiation|guanyl ribonucleotide binding|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|G-protein coupled glutamate receptor binding|filopodium assembly|microtubule cytoskeleton|regulation of dendrite morphogenesis|GTP binding|negative regulation of dendrite morphogenesis|negative regulation of neuron differentiation|endocytosis|neurogenesis|negative regulation of dendritic spine morphogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|guanyl nucleotide binding|pyrophosphatase activity|negative regulation of neuron projection development|regulation of dendritic spine morphogenesis|generation of neurons|type 1 metabotropic glutamate receptor binding|nucleoside-triphosphatase activity|type 5 metabotropic glutamate receptor binding|regulation of neuron differentiation|GTPase activity K01528 dynamin GTPase[3.6.5.5] hsa04144|hsa04072|hsa05100|hsa04721|hsa04961 Endocytosis - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Synaptic vesicle cycle - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) 1:171841498-172418466 0 5 4 20 25 24 0 0.0246410344207586 0.0195548220134029 0.0971602739479265 0.11121733518094 0.121958411721328 0.0147319521447205 0.110112006950065 -2.90195127234103 3.5639294268788e-07 4.8754491736566e-06 DOWN ENSG00000213903 LTB4R leukotriene B4 receptor [Source:HGNC Symbol;Acc:HGNC:6713] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0004872|GO:0050794|GO:0006950|GO:0006955|GO:0038023|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0006952|GO:0005887|GO:0004888|GO:0003012|GO:0006928|GO:0031226|GO:0007154|GO:0007165|GO:0000166|GO:0016021|GO:0098857|GO:0007186|GO:0006936|GO:0006954|GO:0045121|GO:0008528|GO:0004930|GO:0061737|GO:0007200|GO:0007218|GO:0004974|GO:0001632 signal transducer activity|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|regulation of cellular process|response to stress|immune response|signaling receptor activity|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|defense response|integral component of plasma membrane|transmembrane signaling receptor activity|muscle system process|movement of cell or subcellular component|intrinsic component of plasma membrane|cell communication|signal transduction|nucleotide binding|integral component of membrane|membrane microdomain|G-protein coupled receptor signaling pathway|muscle contraction|inflammatory response|membrane raft|G-protein coupled peptide receptor activity|G-protein coupled receptor activity|leukotriene signaling pathway|phospholipase C-activating G-protein coupled receptor signaling pathway|neuropeptide signaling pathway|leukotriene receptor activity|leukotriene B4 receptor activity K04296 leukotriene B4 receptor 1[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 14:24311450-24318036 408 458 297 112 147 194 3.96927780247962 4.04946296266395 2.60508607211812 0.976261727288861 1.1733781886834 1.76881536082197 3.54127561242056 1.30615175893141 1.43894660077063 3.5722372745834e-07 4.88303899246396e-06 UP ENSG00000188938 FAM120AOS family with sequence similarity 120A opposite strand [Source:HGNC Symbol;Acc:HGNC:23389] - - - - - - 9:93446494-93453592 896 934 691 405 475 397 5.81950122884101 5.51321283547577 4.04641133353582 2.35684323844509 2.53127520209679 2.41656002224065 5.12637513261753 2.43489282092751 1.0740807853708 3.58048738236938e-07 4.89207644454259e-06 UP ENSG00000136878 USP20 ubiquitin specific peptidase 20 [Source:HGNC Symbol;Acc:HGNC:12619] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0016787|GO:0005622|GO:0005515|GO:0006810|GO:0005102|GO:0043169|GO:0008233|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0019538|GO:0016192|GO:0005813|GO:0007186|GO:0036459|GO:0046872|GO:0043412|GO:0030163|GO:0008277|GO:0005815|GO:0044265|GO:0036211|GO:0048471|GO:0006508|GO:0001664|GO:0044267|GO:0005856|GO:0044257|GO:0051603|GO:0015630|GO:0004175|GO:0070646|GO:0046914|GO:0006897|GO:0004843|GO:0008234|GO:0006464|GO:0019941|GO:0016579|GO:0004197|GO:0008270|GO:0006511|GO:0070536|GO:0071108 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|hydrolase activity|intracellular|protein binding|transport|receptor binding|cation binding|peptidase activity|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|protein metabolic process|vesicle-mediated transport|centrosome|G-protein coupled receptor signaling pathway|thiol-dependent ubiquitinyl hydrolase activity|metal ion binding|macromolecule modification|protein catabolic process|regulation of G-protein coupled receptor protein signaling pathway|microtubule organizing center|cellular macromolecule catabolic process|protein modification process|perinuclear region of cytoplasm|proteolysis|G-protein coupled receptor binding|cellular protein metabolic process|cytoskeleton|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|endopeptidase activity|protein modification by small protein removal|transition metal ion binding|endocytosis|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|modification-dependent protein catabolic process|protein deubiquitination|cysteine-type endopeptidase activity|zinc ion binding|ubiquitin-dependent protein catabolic process|protein K63-linked deubiquitination|protein K48-linked deubiquitination - - - - 9:129834698-129881838 140 167 149 378 409 371 1.03470511329907 1.12172289957815 0.992863455048818 2.50309567951384 2.48016202325649 2.56975386815914 1.04976382264201 2.51767052364316 -1.26202471150284 3.58234706437126e-07 4.89237828269623e-06 DOWN ENSG00000116874 WARS2 tryptophanyl tRNA synthetase 2, mitochondrial [Source:HGNC Symbol;Acc:HGNC:12730] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0048856|GO:0048514|GO:0006725|GO:1901360|GO:0001568|GO:0006082|GO:0007275|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0006139|GO:0000166|GO:0048869|GO:0044249|GO:0019538|GO:0034645|GO:0006518|GO:0035639|GO:0001944|GO:0072358|GO:0001883|GO:0032549|GO:0001570|GO:0005759|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0030154|GO:0016070|GO:0072359|GO:0016876|GO:0043043|GO:0043039|GO:0005524|GO:0034660|GO:0030554|GO:0006412|GO:0019752|GO:0004812|GO:0006418|GO:0006399|GO:0004830|GO:0006436 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|anatomical structure development|blood vessel morphogenesis|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|blood vessel development|organic acid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|nucleotide binding|cellular developmental process|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|peptide metabolic process|purine ribonucleoside triphosphate binding|vasculature development|cardiovascular system development|purine nucleoside binding|ribonucleoside binding|vasculogenesis|mitochondrial matrix|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|circulatory system development|ligase activity, forming aminoacyl-tRNA and related compounds|peptide biosynthetic process|tRNA aminoacylation|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|translation|carboxylic acid metabolic process|aminoacyl-tRNA ligase activity|tRNA aminoacylation for protein translation|tRNA metabolic process|tryptophan-tRNA ligase activity|tryptophanyl-tRNA aminoacylation K01867 tryptophanyl-tRNA synthetase[6.1.1.2] hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) 1:119031216-119140671 254 300 339 720 728 609 2.8021188991219 3.00782760819102 3.3718328549406 7.11676154707297 6.58948527414902 6.29649035262933 3.06059312075117 6.66757905795044 -1.12335176216496 3.59591568271098e-07 4.90866331923427e-06 DOWN ENSG00000112763 BTN2A1 butyrophilin subfamily 2 member A1 [Source:HGNC Symbol;Acc:HGNC:1136] GO:0005623|GO:0016020|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0071704|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0031982|GO:0005887|GO:0031226|GO:0006629|GO:0070062|GO:0016021 cell|membrane|extracellular region|metabolic process|binding|extracellular vesicle|organic substance metabolic process|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|vesicle|integral component of plasma membrane|intrinsic component of plasma membrane|lipid metabolic process|extracellular exosome|integral component of membrane - - - - 6:26457904-26476621 811 896 666 391 412 411 5.48447448560155 5.50683398777839 4.06071203707435 2.3691250261386 2.28601378247066 2.60486583852886 5.01734017015143 2.42000154904604 1.0519147835859 3.60135156566674e-07 4.91383682090561e-06 UP ENSG00000152939 MARVELD2 MARVEL domain containing 2 [Source:HGNC Symbol;Acc:HGNC:26401] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0043218|GO:0043220|GO:0043209|GO:0045177|GO:0005911|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0009888|GO:0048468|GO:0016323|GO:0016324|GO:0050877|GO:0031982|GO:0022607|GO:0005737|GO:0033010|GO:0048869|GO:0016021|GO:0043296|GO:0045216|GO:0031410|GO:0002064|GO:0034329|GO:0007600|GO:0060429|GO:0030154|GO:0005923|GO:0061689|GO:0003158|GO:0001885|GO:0050954|GO:0030855|GO:0007043|GO:0070830|GO:0061028|GO:0045446|GO:0007605|GO:0043297 developmental process|cell|membrane|cellular process|cell junction|binding|compact myelin|Schmidt-Lanterman incisure|myelin sheath|apical part of cell|cell-cell junction|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|tissue development|cell development|basolateral plasma membrane|apical plasma membrane|neurological system process|vesicle|cellular component assembly|cytoplasm|paranodal junction|cellular developmental process|integral component of membrane|apical junction complex|cell-cell junction organization|cytoplasmic vesicle|epithelial cell development|cell junction assembly|sensory perception|epithelium development|cell differentiation|bicellular tight junction|tricellular tight junction|endothelium development|endothelial cell development|sensory perception of mechanical stimulus|epithelial cell differentiation|cell-cell junction assembly|bicellular tight junction assembly|establishment of endothelial barrier|endothelial cell differentiation|sensory perception of sound|apical junction assembly - - - - 5:69415112-69444330 463 570 518 248 263 285 4.38025016936614 4.90087241331889 4.41837143315488 2.10217179360688 2.04146865617965 2.52692724383621 4.56649800527997 2.22352256454091 1.03824115771037 3.60856231400564e-07 4.92142619106096e-06 UP ENSG00000126882 FAM78A family with sequence similarity 78 member A [Source:HGNC Symbol;Acc:HGNC:25465] - - - - - - 9:131258076-131276547 25 44 59 120 144 175 0.282453037075143 0.451787460705807 0.600991047001356 1.21473340360517 1.33485086224451 1.8529765680976 0.445077181594102 1.46752027798243 -1.72125299532701 3.61159181688818e-07 4.9233087717525e-06 DOWN ENSG00000116353 MECR mitochondrial trans-2-enoyl-CoA reductase [Source:HGNC Symbol;Acc:HGNC:19691] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0044255|GO:0006082|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0006629|GO:0016627|GO:0044249|GO:0055114|GO:0046872|GO:0006631|GO:0005739|GO:0016628|GO:0008610|GO:0005634|GO:0006633|GO:0046914|GO:0019752|GO:0019166|GO:0032787|GO:0008270 cell|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|lipid metabolic process|oxidoreductase activity, acting on the CH-CH group of donors|cellular biosynthetic process|oxidation-reduction process|metal ion binding|fatty acid metabolic process|mitochondrion|oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor|lipid biosynthetic process|nucleus|fatty acid biosynthetic process|transition metal ion binding|carboxylic acid metabolic process|trans-2-enoyl-CoA reductase (NADPH) activity|monocarboxylic acid metabolic process|zinc ion binding K07512 mitochondrial trans-2-enoyl-CoA reductase[1.3.1.38] hsa01100 Metabolic pathways - Homo sapiens (human) 1:29192873-29230942 100 124 143 323 298 333 0.836825694967585 0.943052816491733 1.07891018766023 2.4217842364582 2.04606675588236 2.61160574518464 0.952929566373183 2.3598189125084 -1.30823466482343 3.6298318647227e-07 4.94591512959523e-06 DOWN ENSG00000116095 PLEKHA3 pleckstrin homology domain containing A3 [Source:HGNC Symbol;Acc:HGNC:14338] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0008289|GO:0005622|GO:0012505|GO:0043168|GO:0005543|GO:0043231|GO:0005737|GO:0005794|GO:0035091|GO:0005545 cell|membrane|binding|intracellular organelle|ion binding|membrane-bounded organelle|lipid binding|intracellular|endomembrane system|anion binding|phospholipid binding|intracellular membrane-bounded organelle|cytoplasm|Golgi apparatus|phosphatidylinositol binding|1-phosphatidylinositol binding - - - - 2:178480468-178516462 1322 1526 1163 661 810 618 6.34898115555037 6.66050272736041 5.03577786299791 2.84427326453573 3.19172584646261 2.78156958152007 6.01508724863623 2.9391895641728 1.03316725462861 3.68627198337621e-07 5.02052754524239e-06 UP ENSG00000026036 RTEL1-TNFRSF6B RTEL1-TNFRSF6B readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:44095] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0019222|GO:0006281|GO:0006725|GO:1901360|GO:0051536|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0000723|GO:0043169|GO:0042592|GO:0006139|GO:0000166|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0051539|GO:0034645|GO:0046872|GO:0000725|GO:0035639|GO:0001883|GO:0006302|GO:0016818|GO:0032549|GO:2001020|GO:0006259|GO:0006282|GO:0017076|GO:0009059|GO:0005634|GO:0006974|GO:0000724|GO:0032200|GO:0006260|GO:0005524|GO:0030554|GO:2000779|GO:0000018|GO:0006310|GO:0071103|GO:0016462|GO:0010569|GO:0032392|GO:0017111|GO:0016887|GO:0032508|GO:0004386|GO:0003678|GO:0042623|GO:0008026|GO:0008094|GO:0004003 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|iron-sulfur cluster binding|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|telomere maintenance|cation binding|homeostatic process|nucleobase-containing compound metabolic process|nucleotide binding|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|4 iron, 4 sulfur cluster binding|cellular macromolecule biosynthetic process|metal ion binding|recombinational repair|purine ribonucleoside triphosphate binding|purine nucleoside binding|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|regulation of response to DNA damage stimulus|DNA metabolic process|regulation of DNA repair|purine nucleotide binding|macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|telomere organization|DNA replication|ATP binding|adenyl nucleotide binding|regulation of double-strand break repair|regulation of DNA recombination|DNA recombination|DNA conformation change|pyrophosphatase activity|regulation of double-strand break repair via homologous recombination|DNA geometric change|nucleoside-triphosphatase activity|ATPase activity|DNA duplex unwinding|helicase activity|DNA helicase activity|ATPase activity, coupled|ATP-dependent helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity - - - - 20:63659300-63698684 24 40 52 122 115 187 0.156021668201899 0.236328653907065 0.304787423534176 0.710615526623073 0.613396296733193 1.13932412040641 0.232379248547713 0.821111981254225 -1.82109774474209 3.69255517369203e-07 5.02679170795266e-06 DOWN ENSG00000112183 RBM24 RNA binding motif protein 24 [Source:HGNC Symbol;Acc:HGNC:21539] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043227|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0045595|GO:0003676|GO:0061061|GO:0043231|GO:0005737|GO:0000166|GO:0048869|GO:0043487|GO:0010468|GO:0003723|GO:0042692|GO:0051147|GO:0010467|GO:0030154|GO:0005634|GO:0043488|GO:0051153|GO:0010608|GO:0051146|GO:0044822|GO:0003729|GO:0014902|GO:0010830|GO:0003730 developmental process|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|membrane-bounded organelle|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|nucleic acid binding|muscle structure development|intracellular membrane-bounded organelle|cytoplasm|nucleotide binding|cellular developmental process|regulation of RNA stability|regulation of gene expression|RNA binding|muscle cell differentiation|regulation of muscle cell differentiation|gene expression|cell differentiation|nucleus|regulation of mRNA stability|regulation of striated muscle cell differentiation|posttranscriptional regulation of gene expression|striated muscle cell differentiation|poly(A) RNA binding|mRNA binding|myotube differentiation|regulation of myotube differentiation|mRNA 3'-UTR binding - - - - 6:17281346-17293875 74 72 120 19 24 39 0.479486003660328 0.423988801840524 0.701031967989778 0.110305408117966 0.127593317627107 0.236832156589083 0.534835591163543 0.158243627444719 1.75694807147 3.69832851294412e-07 5.03235640042998e-06 UP ENSG00000130706 ADRM1 adhesion regulating molecule 1 [Source:HGNC Symbol;Acc:HGNC:15759] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0008047|GO:0031325|GO:0046483|GO:0022607|GO:0005887|GO:0043231|GO:0019899|GO:0005737|GO:0032403|GO:0000502|GO:0006139|GO:0031226|GO:0043085|GO:0050790|GO:0016021|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0034645|GO:0016504|GO:0051345|GO:0002020|GO:0031981|GO:0051247|GO:0006508|GO:0005654|GO:0006461|GO:0032270|GO:0044267|GO:0010467|GO:0070628|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0034622|GO:0032774|GO:0030162|GO:0043623|GO:0045862|GO:0052547|GO:0061133|GO:0010952|GO:0006351|GO:0006366|GO:0010950|GO:0043248|GO:0006354|GO:0052548|GO:0006368 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|intracellular|protein binding|plasma membrane|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|enzyme activator activity|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|integral component of plasma membrane|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein complex binding|proteasome complex|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cellular macromolecule biosynthetic process|peptidase activator activity|positive regulation of hydrolase activity|protease binding|nuclear lumen|positive regulation of protein metabolic process|proteolysis|nucleoplasm|protein complex assembly|positive regulation of cellular protein metabolic process|cellular protein metabolic process|gene expression|proteasome binding|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular macromolecular complex assembly|RNA biosynthetic process|regulation of proteolysis|cellular protein complex assembly|positive regulation of proteolysis|regulation of peptidase activity|endopeptidase activator activity|positive regulation of peptidase activity|transcription, DNA-templated|transcription from RNA polymerase II promoter|positive regulation of endopeptidase activity|proteasome assembly|DNA-templated transcription, elongation|regulation of endopeptidase activity|transcription elongation from RNA polymerase II promoter - - - - 20:62302093-62308862 4022 4066 3290 2034 2232 1550 106.197701518216 97.5709351808104 78.3218804420235 48.1195573586722 48.3543155022773 38.3560320644967 94.03017238035 44.9433016418154 1.06501765051641 3.71612430245351e-07 5.05283475357254e-06 UP ENSG00000175354 PTPN2 protein tyrosine phosphatase, non-receptor type 2 [Source:HGNC Symbol;Acc:HGNC:9650] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0040013|GO:0002683|GO:0009892|GO:0048523|GO:0048521|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0050795|GO:0023051|GO:0010888|GO:0007155|GO:0043227|GO:0071944|GO:0002262|GO:0009605|GO:0023057|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0045058|GO:0019222|GO:0044262|GO:0002757|GO:0042127|GO:1903706|GO:0016337|GO:0010883|GO:0006935|GO:0045087|GO:0045595|GO:0010941|GO:0007275|GO:0045596|GO:0048513|GO:0070489|GO:0034101|GO:0005102|GO:0016788|GO:0044281|GO:0006952|GO:0030155|GO:0031325|GO:0043368|GO:0033554|GO:0060761|GO:0010942|GO:1900076|GO:0098609|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0009611|GO:0050920|GO:0005975|GO:0032403|GO:0042592|GO:0001775|GO:0009966|GO:0050839|GO:0010646|GO:0000149|GO:0007162|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0005783|GO:0009968|GO:0050922|GO:0050777|GO:0009725|GO:0008219|GO:0019915|GO:0002695|GO:0008285|GO:0050790|GO:0045061|GO:0043086|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0010876|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0000165|GO:1902533|GO:0051249|GO:2001235|GO:0032268|GO:0006109|GO:0034340|GO:0042113|GO:0030218|GO:1902227|GO:0045059|GO:0007166|GO:0030968|GO:0001959|GO:0043412|GO:0005793|GO:0030097|GO:0034097|GO:0030098|GO:0050727|GO:0006984|GO:0048878|GO:0045824|GO:0034109|GO:1901652|GO:1900101|GO:0071417|GO:0030971|GO:0036211|GO:0032269|GO:0010640|GO:0005178|GO:0010642|GO:0048872|GO:0006954|GO:1902235|GO:0051250|GO:0002429|GO:0050860|GO:0022408|GO:0022407|GO:0034341|GO:0006986|GO:0031981|GO:1901184|GO:0043434|GO:0050728|GO:0007159|GO:1902202|GO:0005996|GO:0005654|GO:1901185|GO:0002764|GO:0019900|GO:0042110|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:1902532|GO:0031328|GO:0046627|GO:0051246|GO:0001960|GO:0030154|GO:0009755|GO:0046626|GO:0043068|GO:0035967|GO:1902531|GO:0019905|GO:0060330|GO:0034976|GO:0032870|GO:0005634|GO:0016051|GO:0042578|GO:0043067|GO:0045638|GO:0045637|GO:1900103|GO:0097190|GO:0045088|GO:0034620|GO:0070059|GO:0002521|GO:1903038|GO:1902206|GO:0002761|GO:0019318|GO:0097193|GO:0016311|GO:0060339|GO:0019221|GO:1903897|GO:2001242|GO:0060334|GO:0050863|GO:0050856|GO:0043065|GO:1902215|GO:2001244|GO:0010803|GO:0071346|GO:1901653|GO:0043408|GO:0030183|GO:0060338|GO:1902212|GO:0045620|GO:0042058|GO:0050868|GO:1902233|GO:0030217|GO:1902232|GO:0060336|GO:0045722|GO:0006111|GO:0071357|GO:0016310|GO:0045619|GO:1902237|GO:0002768|GO:0070371|GO:0070486|GO:0036499|GO:0010804|GO:0033085|GO:0002762|GO:0010906|GO:0007167|GO:0033081|GO:0042059|GO:1903899|GO:0071375|GO:0070104|GO:0042981|GO:0071345|GO:0033077|GO:0016791|GO:0043409|GO:0033673|GO:0032868|GO:0034612|GO:0034111|GO:0030099|GO:0019901|GO:0006464|GO:0038161|GO:0050851|GO:2000587|GO:0070669|GO:0043549|GO:0070670|GO:0006915|GO:0010907|GO:0033500|GO:0070741|GO:0006470|GO:0045650|GO:0042593|GO:0038145|GO:0036006|GO:0007259|GO:0019319|GO:0002573|GO:0045859|GO:0038110|GO:0006469|GO:0060333|GO:0006468|GO:0071356|GO:0045580|GO:0006006|GO:0046425|GO:0045581|GO:0042325|GO:0004721|GO:0071354|GO:0046426|GO:0001932|GO:0070102|GO:0032869|GO:0018193|GO:0042326|GO:1990782|GO:0033209|GO:0050852|GO:0001933|GO:0070372|GO:0071593|GO:0070373|GO:0071353|GO:0035771|GO:0060337|GO:0071352|GO:0007169|GO:0035335|GO:0050730|GO:0061097|GO:0030225|GO:0048008|GO:0061099|GO:0007260|GO:0006094|GO:0050732|GO:0004725|GO:0008286|GO:0038127|GO:0048012|GO:0018108|GO:0042516|GO:0035791|GO:0007173|GO:0042506|GO:0042508|GO:0042518|GO:0042524|GO:0042527|GO:0042503|GO:0004726|GO:0042510|GO:0042512 locomotion|developmental process|immune system process|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of locomotion|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|negative regulation of behavior|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of behavior|regulation of signaling|negative regulation of lipid storage|cell adhesion|membrane-bounded organelle|cell periphery|myeloid cell homeostasis|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|endomembrane system|anatomical structure development|T cell selection|regulation of metabolic process|cellular carbohydrate metabolic process|immune response-activating signal transduction|regulation of cell proliferation|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of lipid storage|chemotaxis|innate immune response|regulation of cell differentiation|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|animal organ development|T cell aggregation|erythrocyte homeostasis|receptor binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|defense response|regulation of cell adhesion|positive regulation of cellular metabolic process|positive T cell selection|cellular response to stress|negative regulation of response to cytokine stimulus|positive regulation of cell death|regulation of cellular response to insulin stimulus|cell-cell adhesion|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|response to wounding|regulation of chemotaxis|carbohydrate metabolic process|protein complex binding|homeostatic process|cell activation|regulation of signal transduction|cell adhesion molecule binding|regulation of cell communication|SNARE binding|negative regulation of cell adhesion|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|endoplasmic reticulum|negative regulation of signal transduction|negative regulation of chemotaxis|negative regulation of immune response|response to hormone|cell death|lipid storage|negative regulation of leukocyte activation|negative regulation of cell proliferation|regulation of catalytic activity|thymic T cell selection|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|response to type I interferon|B cell activation|erythrocyte differentiation|negative regulation of macrophage colony-stimulating factor signaling pathway|positive thymic T cell selection|cell surface receptor signaling pathway|endoplasmic reticulum unfolded protein response|regulation of cytokine-mediated signaling pathway|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|hemopoiesis|response to cytokine|lymphocyte differentiation|regulation of inflammatory response|ER-nucleus signaling pathway|chemical homeostasis|negative regulation of innate immune response|homotypic cell-cell adhesion|response to peptide|regulation of endoplasmic reticulum unfolded protein response|cellular response to organonitrogen compound|receptor tyrosine kinase binding|protein modification process|negative regulation of cellular protein metabolic process|regulation of platelet-derived growth factor receptor signaling pathway|integrin binding|negative regulation of platelet-derived growth factor receptor signaling pathway|homeostasis of number of cells|inflammatory response|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|negative regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|negative regulation of T cell receptor signaling pathway|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|response to interferon-gamma|response to unfolded protein|nuclear lumen|regulation of ERBB signaling pathway|response to peptide hormone|negative regulation of inflammatory response|leukocyte cell-cell adhesion|regulation of hepatocyte growth factor receptor signaling pathway|monosaccharide metabolic process|nucleoplasm|negative regulation of ERBB signaling pathway|immune response-regulating signaling pathway|kinase binding|T cell activation|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|negative regulation of insulin receptor signaling pathway|regulation of protein metabolic process|negative regulation of cytokine-mediated signaling pathway|cell differentiation|hormone-mediated signaling pathway|regulation of insulin receptor signaling pathway|positive regulation of programmed cell death|cellular response to topologically incorrect protein|regulation of intracellular signal transduction|syntaxin binding|regulation of response to interferon-gamma|response to endoplasmic reticulum stress|cellular response to hormone stimulus|nucleus|carbohydrate biosynthetic process|phosphoric ester hydrolase activity|regulation of programmed cell death|negative regulation of myeloid cell differentiation|regulation of myeloid cell differentiation|positive regulation of endoplasmic reticulum unfolded protein response|apoptotic signaling pathway|regulation of innate immune response|cellular response to unfolded protein|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|leukocyte differentiation|negative regulation of leukocyte cell-cell adhesion|negative regulation of interleukin-2-mediated signaling pathway|regulation of myeloid leukocyte differentiation|hexose metabolic process|intrinsic apoptotic signaling pathway|dephosphorylation|negative regulation of type I interferon-mediated signaling pathway|cytokine-mediated signaling pathway|regulation of PERK-mediated unfolded protein response|regulation of intrinsic apoptotic signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of T cell activation|regulation of T cell receptor signaling pathway|positive regulation of apoptotic process|negative regulation of interleukin-4-mediated signaling pathway|positive regulation of intrinsic apoptotic signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway|cellular response to interferon-gamma|cellular response to peptide|regulation of MAPK cascade|B cell differentiation|regulation of type I interferon-mediated signaling pathway|negative regulation of prolactin signaling pathway|negative regulation of lymphocyte differentiation|regulation of epidermal growth factor receptor signaling pathway|negative regulation of T cell activation|negative regulation of positive thymic T cell selection|T cell differentiation|regulation of positive thymic T cell selection|negative regulation of interferon-gamma-mediated signaling pathway|positive regulation of gluconeogenesis|regulation of gluconeogenesis|cellular response to type I interferon|phosphorylation|regulation of lymphocyte differentiation|positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|immune response-regulating cell surface receptor signaling pathway|ERK1 and ERK2 cascade|leukocyte aggregation|PERK-mediated unfolded protein response|negative regulation of tumor necrosis factor-mediated signaling pathway|negative regulation of T cell differentiation in thymus|negative regulation of myeloid leukocyte differentiation|regulation of glucose metabolic process|enzyme linked receptor protein signaling pathway|regulation of T cell differentiation in thymus|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of PERK-mediated unfolded protein response|cellular response to peptide hormone stimulus|negative regulation of interleukin-6-mediated signaling pathway|regulation of apoptotic process|cellular response to cytokine stimulus|T cell differentiation in thymus|phosphatase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|response to insulin|response to tumor necrosis factor|negative regulation of homotypic cell-cell adhesion|myeloid cell differentiation|protein kinase binding|cellular protein modification process|prolactin signaling pathway|antigen receptor-mediated signaling pathway|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|response to interleukin-2|regulation of kinase activity|response to interleukin-4|apoptotic process|positive regulation of glucose metabolic process|carbohydrate homeostasis|response to interleukin-6|protein dephosphorylation|negative regulation of macrophage differentiation|glucose homeostasis|macrophage colony-stimulating factor signaling pathway|cellular response to macrophage colony-stimulating factor stimulus|JAK-STAT cascade|hexose biosynthetic process|myeloid leukocyte differentiation|regulation of protein kinase activity|interleukin-2-mediated signaling pathway|negative regulation of protein kinase activity|interferon-gamma-mediated signaling pathway|protein phosphorylation|cellular response to tumor necrosis factor|regulation of T cell differentiation|glucose metabolic process|regulation of JAK-STAT cascade|negative regulation of T cell differentiation|regulation of phosphorylation|phosphoprotein phosphatase activity|cellular response to interleukin-6|negative regulation of JAK-STAT cascade|regulation of protein phosphorylation|interleukin-6-mediated signaling pathway|cellular response to insulin stimulus|peptidyl-amino acid modification|negative regulation of phosphorylation|protein tyrosine kinase binding|tumor necrosis factor-mediated signaling pathway|T cell receptor signaling pathway|negative regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|lymphocyte aggregation|negative regulation of ERK1 and ERK2 cascade|cellular response to interleukin-4|interleukin-4-mediated signaling pathway|type I interferon signaling pathway|cellular response to interleukin-2|transmembrane receptor protein tyrosine kinase signaling pathway|peptidyl-tyrosine dephosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|macrophage differentiation|platelet-derived growth factor receptor signaling pathway|negative regulation of protein tyrosine kinase activity|tyrosine phosphorylation of STAT protein|gluconeogenesis|negative regulation of peptidyl-tyrosine phosphorylation|protein tyrosine phosphatase activity|insulin receptor signaling pathway|ERBB signaling pathway|hepatocyte growth factor receptor signaling pathway|peptidyl-tyrosine phosphorylation|regulation of tyrosine phosphorylation of Stat3 protein|platelet-derived growth factor receptor-beta signaling pathway|epidermal growth factor receptor signaling pathway|tyrosine phosphorylation of Stat5 protein|tyrosine phosphorylation of Stat1 protein|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|negative regulation of tyrosine phosphorylation of Stat6 protein|tyrosine phosphorylation of Stat3 protein|non-membrane spanning protein tyrosine phosphatase activity|regulation of tyrosine phosphorylation of Stat1 protein|negative regulation of tyrosine phosphorylation of Stat1 protein K18026 tyrosine-protein phosphatase non-receptor type 2[3.1.3.48] hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) 18:12785478-12929643 180 227 269 513 566 530 0.975606289112695 1.1181708678727 1.31452472016065 2.49124628906562 2.51701825175111 2.69219888173059 1.13610062571535 2.56682114084911 -1.17589214907809 3.71676328761482e-07 5.05283475357254e-06 DOWN ENSG00000104313 EYA1 EYA transcriptional coactivator and phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:3519] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0016787|GO:0009058|GO:0032993|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0008284|GO:0042127|GO:0007049|GO:0006281|GO:0090102|GO:0045595|GO:0035239|GO:0006725|GO:0051640|GO:0001822|GO:0009888|GO:0048468|GO:0009314|GO:0022402|GO:0035295|GO:1901360|GO:2001022|GO:0048839|GO:0001568|GO:0010941|GO:0007275|GO:0030324|GO:0016570|GO:0003676|GO:0048513|GO:0050877|GO:0072028|GO:0034641|GO:0016788|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0007389|GO:0001763|GO:0007423|GO:0009887|GO:0051656|GO:0009966|GO:0048729|GO:0048598|GO:0072006|GO:0048568|GO:0050673|GO:0030323|GO:0060548|GO:0010646|GO:0006139|GO:0008104|GO:0007163|GO:0007154|GO:0001704|GO:0007165|GO:0003151|GO:0009968|GO:0051649|GO:0008219|GO:0048645|GO:0048869|GO:0009967|GO:0044249|GO:0007017|GO:0019538|GO:0031323|GO:0006996|GO:0050679|GO:0051276|GO:0051653|GO:0060479|GO:0048705|GO:0010468|GO:0034645|GO:0003156|GO:0046872|GO:0003723|GO:0007166|GO:0002009|GO:1903047|GO:0001944|GO:0043412|GO:0007010|GO:0072164|GO:0072358|GO:0001655|GO:0043583|GO:0007498|GO:0043069|GO:2001234|GO:0051252|GO:0060541|GO:0006325|GO:0003007|GO:0048754|GO:0060795|GO:0061138|GO:0090103|GO:0009790|GO:0001656|GO:0010628|GO:0006302|GO:0072513|GO:0042474|GO:0036211|GO:0000278|GO:0060840|GO:0060537|GO:0007369|GO:0048844|GO:0060037|GO:2000027|GO:0072001|GO:0045739|GO:0042472|GO:0060914|GO:0007600|GO:0001707|GO:0031981|GO:0030010|GO:2001020|GO:0045747|GO:0001708|GO:0008593|GO:0005654|GO:0006259|GO:0048752|GO:0050678|GO:0060872|GO:0061326|GO:0034613|GO:0051293|GO:0006282|GO:0060993|GO:0012501|GO:0060429|GO:0051054|GO:0006796|GO:0010212|GO:0072073|GO:0044267|GO:0010467|GO:0048562|GO:0007399|GO:0060562|GO:0031328|GO:0071599|GO:0009059|GO:0030154|GO:0001501|GO:0001823|GO:0042473|GO:0016576|GO:0016070|GO:0072359|GO:0000226|GO:0060428|GO:0010557|GO:0005634|GO:0042578|GO:0043067|GO:0006974|GO:0048332|GO:0051960|GO:0045165|GO:0097190|GO:0030182|GO:2001237|GO:0071600|GO:0048706|GO:0045893|GO:0016311|GO:0009792|GO:0001657|GO:0050954|GO:0030855|GO:0060487|GO:0051294|GO:0032774|GO:2001240|GO:0048333|GO:2001141|GO:0097192|GO:0072078|GO:2001236|GO:0072163|GO:0001658|GO:0048663|GO:0042471|GO:0061333|GO:0048665|GO:0040001|GO:0035909|GO:0072080|GO:0000132|GO:0042981|GO:0035904|GO:0043066|GO:0016791|GO:0016568|GO:0048704|GO:0001710|GO:0003264|GO:0007501|GO:0007219|GO:0014706|GO:0022008|GO:0035088|GO:0006464|GO:2000826|GO:0050767|GO:0097191|GO:0006351|GO:0006915|GO:0006355|GO:0006470|GO:0045944|GO:0006366|GO:0007605|GO:0006357|GO:0048699|GO:1903506|GO:0003266|GO:2001239|GO:0004721|GO:0018193|GO:0060675|GO:0043009|GO:0045664|GO:0032446|GO:0035335|GO:0018205|GO:0004725|GO:0016925 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|biosynthetic process|protein-DNA complex|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|regulation of cell proliferation|cell cycle|DNA repair|cochlea development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|organelle localization|kidney development|tissue development|cell development|response to radiation|cell cycle process|tube development|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|inner ear development|blood vessel development|regulation of cell death|multicellular organism development|lung development|histone modification|nucleic acid binding|animal organ development|neurological system process|nephron morphogenesis|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|pattern specification process|morphogenesis of a branching structure|sensory organ development|organ morphogenesis|establishment of organelle localization|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|nephron development|embryonic organ development|epithelial cell proliferation|respiratory tube development|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|establishment or maintenance of cell polarity|cell communication|formation of primary germ layer|signal transduction|outflow tract morphogenesis|negative regulation of signal transduction|establishment of localization in cell|cell death|organ formation|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|microtubule-based process|protein metabolic process|regulation of cellular metabolic process|organelle organization|positive regulation of epithelial cell proliferation|chromosome organization|spindle localization|lung cell differentiation|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of organ formation|metal ion binding|RNA binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|mitotic cell cycle process|vasculature development|macromolecule modification|cytoskeleton organization|mesonephric tubule development|cardiovascular system development|urogenital system development|ear development|mesoderm development|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|respiratory system development|chromatin organization|heart morphogenesis|branching morphogenesis of an epithelial tube|cell fate commitment involved in formation of primary germ layer|morphogenesis of a branching epithelium|cochlea morphogenesis|embryo development|metanephros development|positive regulation of gene expression|double-strand break repair|positive regulation of secondary heart field cardioblast proliferation|middle ear morphogenesis|protein modification process|mitotic cell cycle|artery development|muscle tissue development|gastrulation|artery morphogenesis|pharyngeal system development|regulation of organ morphogenesis|renal system development|positive regulation of DNA repair|inner ear morphogenesis|heart formation|sensory perception|mesoderm formation|nuclear lumen|establishment of cell polarity|regulation of response to DNA damage stimulus|positive regulation of Notch signaling pathway|cell fate specification|regulation of Notch signaling pathway|nucleoplasm|DNA metabolic process|semicircular canal morphogenesis|regulation of epithelial cell proliferation|semicircular canal development|renal tubule development|cellular protein localization|establishment of spindle localization|regulation of DNA repair|kidney morphogenesis|programmed cell death|epithelium development|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|response to ionizing radiation|kidney epithelium development|cellular protein metabolic process|gene expression|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|positive regulation of cellular biosynthetic process|otic vesicle development|macromolecule biosynthetic process|cell differentiation|skeletal system development|mesonephros development|outer ear morphogenesis|histone dephosphorylation|RNA metabolic process|circulatory system development|microtubule cytoskeleton organization|lung epithelium development|positive regulation of macromolecule biosynthetic process|nucleus|phosphoric ester hydrolase activity|regulation of programmed cell death|cellular response to DNA damage stimulus|mesoderm morphogenesis|regulation of nervous system development|cell fate commitment|apoptotic signaling pathway|neuron differentiation|negative regulation of extrinsic apoptotic signaling pathway|otic vesicle morphogenesis|embryonic skeletal system development|positive regulation of transcription, DNA-templated|dephosphorylation|embryo development ending in birth or egg hatching|ureteric bud development|sensory perception of mechanical stimulus|epithelial cell differentiation|lung epithelial cell differentiation|establishment of spindle orientation|RNA biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|mesodermal cell differentiation|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|nephron tubule morphogenesis|regulation of extrinsic apoptotic signaling pathway|mesonephric epithelium development|branching involved in ureteric bud morphogenesis|neuron fate commitment|ear morphogenesis|renal tubule morphogenesis|neuron fate specification|establishment of mitotic spindle localization|aorta morphogenesis|nephron tubule development|establishment of mitotic spindle orientation|regulation of apoptotic process|aorta development|negative regulation of apoptotic process|phosphatase activity|chromatin modification|embryonic skeletal system morphogenesis|mesodermal cell fate commitment|regulation of cardioblast proliferation|mesodermal cell fate specification|Notch signaling pathway|striated muscle tissue development|neurogenesis|establishment or maintenance of apical/basal cell polarity|cellular protein modification process|regulation of heart morphogenesis|regulation of neurogenesis|extrinsic apoptotic signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|protein dephosphorylation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|sensory perception of sound|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|regulation of secondary heart field cardioblast proliferation|regulation of extrinsic apoptotic signaling pathway in absence of ligand|phosphoprotein phosphatase activity|peptidyl-amino acid modification|ureteric bud morphogenesis|chordate embryonic development|regulation of neuron differentiation|protein modification by small protein conjugation|peptidyl-tyrosine dephosphorylation|peptidyl-lysine modification|protein tyrosine phosphatase activity|protein sumoylation K15616 eyes absent homolog 1[3.1.3.48] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 8:71197433-71362232 9 0 3 49 43 25 0.0482189803081068 0 0.0144891904728676 0.23521666291122 0.189018744262472 0.125528681715834 0.0209027235936581 0.183254696296509 -3.13208733032699 3.73895398493994e-07 5.08068876952194e-06 DOWN ENSG00000080298 RFX3 regulatory factor X3 [Source:HGNC Symbol;Acc:HGNC:9984] GO:0040011|GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0060341|GO:0045595|GO:0006725|GO:0009888|GO:0001539|GO:0048468|GO:0006810|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0032940|GO:0031325|GO:0046483|GO:0022607|GO:0045597|GO:0043231|GO:0000981|GO:0007389|GO:0007267|GO:0032880|GO:0006928|GO:0005667|GO:0031018|GO:0045184|GO:0009890|GO:2000078|GO:0046883|GO:0010646|GO:0006139|GO:0000790|GO:0008104|GO:0007154|GO:0031016|GO:0030030|GO:0010817|GO:0048869|GO:0044249|GO:0007017|GO:0031324|GO:0031323|GO:0006996|GO:0000902|GO:0003677|GO:0010468|GO:0034645|GO:0060285|GO:0090276|GO:0010629|GO:0010720|GO:0002064|GO:0051252|GO:0051223|GO:0015031|GO:0010628|GO:0044782|GO:0030856|GO:0070201|GO:0042886|GO:0003705|GO:0051046|GO:0003309|GO:0035270|GO:0031981|GO:0030031|GO:0007018|GO:0009914|GO:0009306|GO:0030858|GO:0005694|GO:0000228|GO:0070925|GO:0060429|GO:0042384|GO:0010467|GO:0032990|GO:0046903|GO:0031328|GO:0009059|GO:0030154|GO:0048858|GO:0048469|GO:0016070|GO:0010557|GO:0005634|GO:0050796|GO:0060271|GO:0003323|GO:0002790|GO:0000975|GO:0045893|GO:0030073|GO:0030855|GO:0045892|GO:0032774|GO:0002066|GO:0043565|GO:2001141|GO:0050708|GO:0015833|GO:1902679|GO:0003690|GO:0009855|GO:2000074|GO:0002070|GO:0046879|GO:0006351|GO:0006355|GO:0003341|GO:0045944|GO:0006366|GO:0030072|GO:1903507|GO:0003351|GO:0006357|GO:0007368|GO:1903506|GO:0044212|GO:0002068|GO:0072560|GO:0002071|GO:0002067|GO:0060287|GO:0000976|GO:0001012|GO:0001159|GO:0035883|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cell motility|regulation of signaling|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cellular localization|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cilium or flagellum-dependent cell motility|cell development|transport|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|secretion by cell|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|cell-cell signaling|regulation of protein localization|movement of cell or subcellular component|transcription factor complex|endocrine pancreas development|establishment of protein localization|negative regulation of biosynthetic process|positive regulation of type B pancreatic cell development|regulation of hormone secretion|regulation of cell communication|nucleobase-containing compound metabolic process|nuclear chromatin|protein localization|cell communication|pancreas development|cell projection organization|regulation of hormone levels|cellular developmental process|cellular biosynthetic process|microtubule-based process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|cell morphogenesis|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cilium-dependent cell motility|regulation of peptide hormone secretion|negative regulation of gene expression|positive regulation of cell development|epithelial cell development|regulation of RNA metabolic process|regulation of protein transport|protein transport|positive regulation of gene expression|cilium organization|regulation of epithelial cell differentiation|regulation of establishment of protein localization|amide transport|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|regulation of secretion|type B pancreatic cell differentiation|endocrine system development|nuclear lumen|cell projection assembly|microtubule-based movement|hormone transport|protein secretion|positive regulation of epithelial cell differentiation|chromosome|nuclear chromosome|organelle assembly|epithelium development|cilium assembly|gene expression|cell part morphogenesis|secretion|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|cell maturation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of insulin secretion|cilium morphogenesis|type B pancreatic cell development|peptide secretion|regulatory region DNA binding|positive regulation of transcription, DNA-templated|insulin secretion|epithelial cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|columnar/cuboidal epithelial cell development|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of protein secretion|peptide transport|negative regulation of RNA biosynthetic process|double-stranded DNA binding|determination of bilateral symmetry|regulation of type B pancreatic cell development|epithelial cell maturation|hormone secretion|transcription, DNA-templated|regulation of transcription, DNA-templated|cilium movement|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|negative regulation of nucleic acid-templated transcription|epithelial cilium movement|regulation of transcription from RNA polymerase II promoter|determination of left/right symmetry|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|glandular epithelial cell development|type B pancreatic cell maturation|glandular epithelial cell maturation|glandular epithelial cell differentiation|epithelial cilium movement involved in determination of left/right asymmetry|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|enteroendocrine cell differentiation|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 9:3218297-3526004 26 23 66 127 155 169 0.0898850934754503 0.0722661831032925 0.205719072140932 0.393386430238688 0.439661118478867 0.547563721413538 0.122623449573225 0.460203756710364 -1.90803786513251 3.77353567783697e-07 5.12534732148066e-06 DOWN ENSG00000081019 RSBN1 round spermatid basic protein 1 [Source:HGNC Symbol;Acc:HGNC:25642] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|nucleus - - - - 1:113761832-113812476 202 258 416 756 741 699 0.813391149599722 0.94416371243809 1.51027506956768 2.72751873487026 2.44813063868022 2.63787720779349 1.0892766438685 2.60450886044799 -1.25764094287535 3.79895084287244e-07 5.15752062133305e-06 DOWN ENSG00000109184 DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 [Source:HGNC Symbol;Acc:HGNC:28998] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0032182|GO:0097602|GO:0031325|GO:0043231|GO:0019899|GO:0043085|GO:0050790|GO:0000151|GO:0019538|GO:0031323|GO:0032268|GO:0043412|GO:0051347|GO:0036211|GO:0051351|GO:1990234|GO:0051247|GO:0032270|GO:0044267|GO:0044390|GO:0051246|GO:0005634|GO:0031401|GO:0051438|GO:0051443|GO:0031624|GO:0006464|GO:0032446|GO:0031398|GO:0031396|GO:0016567|GO:0045116 macromolecular complex|cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|protein complex|regulation of metabolic process|ubiquitin-like protein binding|cullin family protein binding|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|enzyme binding|positive regulation of catalytic activity|regulation of catalytic activity|ubiquitin ligase complex|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|positive regulation of transferase activity|protein modification process|positive regulation of ligase activity|transferase complex|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein metabolic process|nucleus|positive regulation of protein modification process|regulation of ubiquitin-protein transferase activity|positive regulation of ubiquitin-protein transferase activity|ubiquitin conjugating enzyme binding|cellular protein modification process|protein modification by small protein conjugation|positive regulation of protein ubiquitination|regulation of protein ubiquitination|protein ubiquitination|protein neddylation - - - - 4:51843000-51916837 181 190 357 627 640 641 0.827409726747028 0.789361987528965 1.47138407663306 2.56808066182877 2.40044100825126 2.74618857826986 1.02938526363635 2.5715700827833 -1.32086643724753 3.81394584828647e-07 5.17552451612474e-06 DOWN ENSG00000081721 DUSP12 dual specificity phosphatase 12 [Source:HGNC Symbol;Acc:HGNC:3067] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0016787|GO:0005622|GO:0005515|GO:0019222|GO:0044262|GO:0016788|GO:0044281|GO:0031325|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0005975|GO:0043085|GO:0050790|GO:0019538|GO:0031323|GO:0006109|GO:0046872|GO:0043412|GO:0051347|GO:0036211|GO:0005996|GO:0019900|GO:0006796|GO:0044267|GO:0051174|GO:0005634|GO:0042578|GO:0019318|GO:0016311|GO:1903301|GO:0016310|GO:0010906|GO:0046914|GO:0016791|GO:0006464|GO:0043549|GO:0033674|GO:0006470|GO:0006006|GO:0042325|GO:0004721|GO:0033133|GO:0008270|GO:0042327|GO:0035335|GO:0008138|GO:0004725 cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|intracellular|protein binding|regulation of metabolic process|cellular carbohydrate metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|carbohydrate metabolic process|positive regulation of catalytic activity|regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|regulation of carbohydrate metabolic process|metal ion binding|macromolecule modification|positive regulation of transferase activity|protein modification process|monosaccharide metabolic process|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|nucleus|phosphoric ester hydrolase activity|hexose metabolic process|dephosphorylation|positive regulation of hexokinase activity|phosphorylation|regulation of glucose metabolic process|transition metal ion binding|phosphatase activity|cellular protein modification process|regulation of kinase activity|positive regulation of kinase activity|protein dephosphorylation|glucose metabolic process|regulation of phosphorylation|phosphoprotein phosphatase activity|positive regulation of glucokinase activity|zinc ion binding|positive regulation of phosphorylation|peptidyl-tyrosine dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity - - - - 1:161749758-161757238 1012 1071 537 378 395 270 20.0914057678888 19.3241065957499 9.61210014579279 6.72386436952763 6.43421113289379 5.02369008924972 16.3425375031438 6.06058853055705 1.43110220531291 3.83133728333677e-07 5.19676252870222e-06 UP ENSG00000171365 CLCN5 chloride channel, voltage-sensitive 5 [Source:HGNC Symbol;Acc:HGNC:2023] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0036094|GO:0097159|GO:0022857|GO:0050794|GO:0043229|GO:0043167|GO:0045177|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0043168|GO:0001882|GO:0005887|GO:0043231|GO:0005774|GO:0005737|GO:0022891|GO:0031226|GO:0055085|GO:0007588|GO:0010008|GO:0000166|GO:0016021|GO:0005794|GO:0005768|GO:0035639|GO:0001883|GO:0005773|GO:0015267|GO:0006811|GO:0032549|GO:0015075|GO:0034765|GO:0043269|GO:0000139|GO:0017076|GO:0034220|GO:0006820|GO:0005216|GO:0098656|GO:0000323|GO:0005524|GO:0015297|GO:0008509|GO:0030554|GO:0044070|GO:1903959|GO:0005765|GO:0005244|GO:0005253|GO:0005764|GO:0015698|GO:0005254|GO:1902476|GO:0008308|GO:0006821|GO:0015108|GO:0005247 transporter activity|cell|membrane|cellular process|binding|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|regulation of cellular process|intracellular organelle|ion binding|apical part of cell|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|organelle membrane|transport|anion binding|nucleoside binding|integral component of plasma membrane|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|excretion|endosome membrane|nucleotide binding|integral component of membrane|Golgi apparatus|endosome|purine ribonucleoside triphosphate binding|purine nucleoside binding|vacuole|channel activity|ion transport|ribonucleoside binding|ion transmembrane transporter activity|regulation of ion transmembrane transport|regulation of ion transport|Golgi membrane|purine nucleotide binding|ion transmembrane transport|anion transport|ion channel activity|anion transmembrane transport|lytic vacuole|ATP binding|antiporter activity|anion transmembrane transporter activity|adenyl nucleotide binding|regulation of anion transport|regulation of anion transmembrane transport|lysosomal membrane|voltage-gated ion channel activity|anion channel activity|lysosome|inorganic anion transport|chloride channel activity|chloride transmembrane transport|voltage-gated anion channel activity|chloride transport|chloride transmembrane transporter activity|voltage-gated chloride channel activity - - - - X:49922615-50099235 11 16 30 55 113 87 0.0626794202436173 0.0828578083828832 0.154122346668895 0.28079996101642 0.528298434906887 0.464601660654543 0.0998865250984652 0.42456668552595 -2.08762919806023 3.83977083112323e-07 5.20583643925309e-06 DOWN ENSG00000078140 UBE2K ubiquitin conjugating enzyme E2K [Source:HGNC Symbol;Acc:HGNC:4914] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0009893|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0019222|GO:0045087|GO:0060760|GO:0043168|GO:0006952|GO:0001882|GO:0031982|GO:0031325|GO:0033554|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0042592|GO:0009966|GO:0019725|GO:0010646|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0070062|GO:0032433|GO:0008219|GO:0019787|GO:0000166|GO:0009967|GO:0019538|GO:0010033|GO:0031323|GO:0032268|GO:0034340|GO:0007166|GO:0001959|GO:0035639|GO:0043412|GO:0034097|GO:0030163|GO:0004842|GO:0001883|GO:0044265|GO:0010994|GO:0036211|GO:0001961|GO:0032549|GO:0010992|GO:0051247|GO:0006508|GO:0030175|GO:0006461|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0042176|GO:0071310|GO:0017076|GO:0051246|GO:0034976|GO:0005634|GO:0045089|GO:0097190|GO:0045088|GO:0044389|GO:0031625|GO:0070059|GO:0044257|GO:0097193|GO:0019221|GO:0035456|GO:0031401|GO:0061630|GO:0034622|GO:0010498|GO:0060338|GO:0005524|GO:0030162|GO:0043623|GO:0030554|GO:0071357|GO:0016310|GO:0051603|GO:0071345|GO:0060340|GO:0006464|GO:0006915|GO:0051258|GO:0035458|GO:0019941|GO:0006468|GO:0042325|GO:0001932|GO:0018193|GO:0001934|GO:0034450|GO:0061136|GO:0042327|GO:0060337|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0018107|GO:0010800|GO:0016567|GO:0000209|GO:0070936 immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|transferase activity|regulation of metabolic process|innate immune response|positive regulation of response to cytokine stimulus|anion binding|defense response|nucleoside binding|vesicle|positive regulation of cellular metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|homeostatic process|regulation of signal transduction|cellular homeostasis|regulation of cell communication|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|extracellular exosome|filopodium tip|cell death|ubiquitin-like protein transferase activity|nucleotide binding|positive regulation of signal transduction|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of cellular protein metabolic process|response to type I interferon|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|response to cytokine|protein catabolic process|ubiquitin-protein transferase activity|purine nucleoside binding|cellular macromolecule catabolic process|free ubiquitin chain polymerization|protein modification process|positive regulation of cytokine-mediated signaling pathway|ribonucleoside binding|ubiquitin homeostasis|positive regulation of protein metabolic process|proteolysis|filopodium|protein complex assembly|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|cellular response to organic substance|purine nucleotide binding|regulation of protein metabolic process|response to endoplasmic reticulum stress|nucleus|positive regulation of innate immune response|apoptotic signaling pathway|regulation of innate immune response|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular protein catabolic process|intrinsic apoptotic signaling pathway|cytokine-mediated signaling pathway|response to interferon-beta|positive regulation of protein modification process|ubiquitin protein ligase activity|cellular macromolecular complex assembly|proteasomal protein catabolic process|regulation of type I interferon-mediated signaling pathway|ATP binding|regulation of proteolysis|cellular protein complex assembly|adenyl nucleotide binding|cellular response to type I interferon|phosphorylation|proteolysis involved in cellular protein catabolic process|cellular response to cytokine stimulus|positive regulation of type I interferon-mediated signaling pathway|cellular protein modification process|apoptotic process|protein polymerization|cellular response to interferon-beta|modification-dependent protein catabolic process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|ubiquitin-ubiquitin ligase activity|regulation of proteasomal protein catabolic process|positive regulation of phosphorylation|type I interferon signaling pathway|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|peptidyl-threonine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|protein ubiquitination|protein polyubiquitination|protein K48-linked ubiquitination K04649 ubiquitin-conjugating enzyme (huntingtin interacting protein 2)[2.3.2.23] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 4:39698044-39782792 981 1511 1639 3124 3526 2808 6.54402479330172 9.16053051346316 9.85755600851443 18.6717385184552 19.2986227849913 17.5550465923251 8.52070377175977 18.5084692985905 -1.11914108468847 3.87357783746648e-07 5.24928700679638e-06 DOWN ENSG00000165724 ZMYND19 zinc finger, MYND-type containing 19 [Source:HGNC Symbol;Acc:HGNC:21146] GO:0045202|GO:0005623|GO:0016020|GO:0005488|GO:0043167|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043169|GO:0005737|GO:0046872 synapse|cell|membrane|binding|ion binding|cell periphery|intracellular|protein binding|plasma membrane|cation binding|cytoplasm|metal ion binding - - - - 9:137582079-137590490 1107 1299 1042 597 674 355 29.7288023558594 31.7043647208371 25.2296866831353 14.3648894081797 14.8510638114328 8.9348524345508 28.8876179199439 12.7169352180544 1.18370022087644 3.87637551779323e-07 5.25069485971865e-06 UP ENSG00000253910 PCDHGB2 protocadherin gamma subfamily B, 2 [Source:HGNC Symbol;Acc:HGNC:8709] GO:0005623|GO:0016020|GO:0005488|GO:0043167|GO:0007155|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0098609|GO:0043169|GO:0016021|GO:0098742|GO:0046872|GO:0005509|GO:0007156 cell|membrane|binding|ion binding|cell adhesion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|cell-cell adhesion|cation binding|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|metal ion binding|calcium ion binding|homophilic cell adhesion via plasma membrane adhesion molecules - - - - 5:141360042-141512979 0 0 1 12 15 8 0 0 0.00886574100415083 0.105781673335468 0.121084796338204 0.0737630709001595 0.00295524700138361 0.100209846857944 -5.08360175112843 3.89160942530415e-07 5.26893912848209e-06 DOWN ENSG00000145337 PYURF PIGY upstream reading frame [Source:HGNC Symbol;Acc:HGNC:44317] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0000506|GO:0044255|GO:0019637|GO:0043231|GO:0005737|GO:0006629|GO:0005783|GO:0044249|GO:0019538|GO:0008654|GO:0034645|GO:0046486|GO:0043412|GO:0006643|GO:0036211|GO:0042157|GO:0005739|GO:0006796|GO:1901137|GO:0044267|GO:0008610|GO:0009059|GO:0006644|GO:0046474|GO:0009247|GO:0006664|GO:0042158|GO:0006464|GO:0006650|GO:0006506|GO:0046488|GO:0006661|GO:0006505|GO:0006497 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|cellular lipid metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|endoplasmic reticulum|cellular biosynthetic process|protein metabolic process|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|glycerolipid metabolic process|macromolecule modification|membrane lipid metabolic process|protein modification process|lipoprotein metabolic process|mitochondrion|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|lipid biosynthetic process|macromolecule biosynthetic process|phospholipid metabolic process|glycerophospholipid biosynthetic process|glycolipid biosynthetic process|glycolipid metabolic process|lipoprotein biosynthetic process|cellular protein modification process|glycerophospholipid metabolic process|GPI anchor biosynthetic process|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|GPI anchor metabolic process|protein lipidation - - - - 4:88520985-88523813 2289 2337 1860 1143 1276 857 118.968880386517 110.389153513145 87.1595196837731 53.2269257740252 54.413454559677 41.7443100517965 105.505851194478 49.7948967951662 1.08325320972022 3.93795488081941e-07 5.32927039945525e-06 UP ENSG00000277363 SRCIN1 SRC kinase signaling inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:29506] GO:0040011|GO:0032502|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0060076|GO:0040012|GO:0043229|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0044297|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009893|GO:0031252|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0019222|GO:0060341|GO:0045595|GO:0048468|GO:0043025|GO:0006810|GO:0034446|GO:0007275|GO:0016358|GO:0032940|GO:0031325|GO:0051128|GO:0045211|GO:0019899|GO:0005737|GO:0032880|GO:0006928|GO:0043005|GO:0031589|GO:0030027|GO:0045184|GO:0036477|GO:0014069|GO:0019904|GO:0043085|GO:0008104|GO:0044092|GO:0060996|GO:0051270|GO:0016477|GO:0050790|GO:0051048|GO:1903531|GO:0030030|GO:0043086|GO:0048869|GO:2000145|GO:0019538|GO:0051224|GO:0031324|GO:0031323|GO:0016192|GO:0032268|GO:0000902|GO:0060998|GO:0031175|GO:0031344|GO:0060997|GO:0030424|GO:0043412|GO:0050773|GO:0097061|GO:0048813|GO:0050709|GO:0051223|GO:0015031|GO:0000904|GO:0030334|GO:0006887|GO:0051347|GO:0036211|GO:0032269|GO:0070201|GO:0051046|GO:0030425|GO:0009306|GO:0051247|GO:0022604|GO:0030175|GO:0019900|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0046903|GO:0051246|GO:0030154|GO:0048858|GO:0005856|GO:0051960|GO:0048666|GO:0030182|GO:0015629|GO:0010975|GO:0031401|GO:0010769|GO:0050708|GO:0016310|GO:0048814|GO:0033673|GO:0019901|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0061001|GO:0043549|GO:0033674|GO:0045859|GO:0045860|GO:0006469|GO:0006468|GO:0048699|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:0001934|GO:0001933|GO:0045664|GO:0042327|GO:0050731|GO:0050730|GO:0061097|GO:0061099|GO:0061098|GO:0050732|GO:0018108 locomotion|developmental process|synapse|cell|membrane|cellular process|metabolic process|binding|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|excitatory synapse|regulation of locomotion|intracellular organelle|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|cell body|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|positive regulation of metabolic process|cell leading edge|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|synaptic membrane|regulation of metabolic process|regulation of cellular localization|regulation of cell differentiation|cell development|neuronal cell body|transport|substrate adhesion-dependent cell spreading|multicellular organism development|dendrite development|secretion by cell|positive regulation of cellular metabolic process|regulation of cellular component organization|postsynaptic membrane|enzyme binding|cytoplasm|regulation of protein localization|movement of cell or subcellular component|neuron projection|cell-substrate adhesion|lamellipodium|establishment of protein localization|somatodendritic compartment|postsynaptic density|protein domain specific binding|positive regulation of catalytic activity|protein localization|negative regulation of molecular function|dendritic spine development|regulation of cellular component movement|cell migration|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|cell projection organization|negative regulation of catalytic activity|cellular developmental process|regulation of cell motility|protein metabolic process|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|vesicle-mediated transport|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|neuron projection development|regulation of cell projection organization|dendritic spine morphogenesis|axon|macromolecule modification|regulation of dendrite development|dendritic spine organization|dendrite morphogenesis|negative regulation of protein secretion|regulation of protein transport|protein transport|cell morphogenesis involved in differentiation|regulation of cell migration|exocytosis|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|regulation of secretion|dendrite|protein secretion|positive regulation of protein metabolic process|regulation of cell morphogenesis|filopodium|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|secretion|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|cytoskeleton|regulation of nervous system development|neuron development|neuron differentiation|actin cytoskeleton|regulation of neuron projection development|positive regulation of protein modification process|regulation of cell morphogenesis involved in differentiation|regulation of protein secretion|phosphorylation|regulation of dendrite morphogenesis|negative regulation of kinase activity|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|regulation of dendritic spine morphogenesis|regulation of kinase activity|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|generation of neurons|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|regulation of neuron differentiation|positive regulation of phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation - - - - 17:38530016-38605930 165 171 232 403 498 515 0.730799643385691 0.688320022552048 0.92643588836736 1.59924976549319 1.8097170651172 2.13771588449686 0.781851851435033 1.84889423836908 -1.24169553049795 3.96208908380423e-07 5.35950192604855e-06 DOWN ENSG00000124496 TRERF1 transcriptional regulating factor 1 [Source:HGNC Symbol;Acc:HGNC:18273] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0042445|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0044281|GO:0031325|GO:0046483|GO:0032350|GO:0043231|GO:0043169|GO:0001076|GO:0042592|GO:0006139|GO:0006629|GO:0008134|GO:0042446|GO:0010817|GO:0044249|GO:0031323|GO:0003713|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0001104|GO:0016042|GO:0051252|GO:0006066|GO:0010628|GO:0008202|GO:0010467|GO:0008610|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0046885|GO:0045893|GO:0032774|GO:0046164|GO:2001141|GO:0006694|GO:0008301|GO:0006706|GO:0030374|GO:0016125|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0008203|GO:0006707 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|hormone metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of hormone metabolic process|intracellular membrane-bounded organelle|cation binding|transcription factor activity, RNA polymerase II transcription factor binding|homeostatic process|nucleobase-containing compound metabolic process|lipid metabolic process|transcription factor binding|hormone biosynthetic process|regulation of hormone levels|cellular biosynthetic process|regulation of cellular metabolic process|transcription coactivator activity|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|RNA polymerase II transcription cofactor activity|lipid catabolic process|regulation of RNA metabolic process|alcohol metabolic process|positive regulation of gene expression|steroid metabolic process|gene expression|lipid biosynthetic process|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of hormone biosynthetic process|positive regulation of transcription, DNA-templated|RNA biosynthetic process|alcohol catabolic process|regulation of RNA biosynthetic process|steroid biosynthetic process|DNA binding, bending|steroid catabolic process|ligand-dependent nuclear receptor transcription coactivator activity|sterol metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|cholesterol metabolic process|cholesterol catabolic process - - - - 6:42224931-42452051 308 378 573 838 1272 976 1.52794244352818 1.70423318852683 2.56286246882584 3.72476044425207 5.17740199088862 4.5376952742092 1.93167936696028 4.4799525697833 -1.21362781235299 3.97683116109339e-07 5.37700713239503e-06 DOWN ENSG00000128683 GAD1 glutamate decarboxylase 1 [Source:HGNC Symbol;Acc:HGNC:4092] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0048786|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0043227|GO:0048037|GO:0071944|GO:0009058|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0031090|GO:0016830|GO:0047485|GO:0042133|GO:0006810|GO:0006082|GO:0043168|GO:0044281|GO:0032940|GO:0031982|GO:0043231|GO:0005737|GO:0006520|GO:0007267|GO:0012506|GO:0043177|GO:0046983|GO:0042493|GO:0007154|GO:0030170|GO:0051649|GO:0001505|GO:0044249|GO:0019538|GO:0006836|GO:0043412|GO:0031410|GO:0046982|GO:0016023|GO:0036211|GO:0030665|GO:0009063|GO:0016831|GO:0008652|GO:0031988|GO:0030659|GO:0044267|GO:0031406|GO:0046903|GO:0009448|GO:0042136|GO:0046395|GO:0061202|GO:0030135|GO:0009449|GO:0016597|GO:0019752|GO:0004351|GO:0006464|GO:0030136|GO:0043648|GO:0016595|GO:0032787|GO:0043649|GO:0007268|GO:0006536|GO:0006538|GO:0018352|GO:0006105|GO:0006540 synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|presynaptic active zone|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|membrane-bounded organelle|cofactor binding|cell periphery|biosynthetic process|intracellular|neurotransmitter secretion|protein binding|plasma membrane|organelle membrane|carbon-carbon lyase activity|protein N-terminus binding|neurotransmitter metabolic process|transport|organic acid metabolic process|anion binding|small molecule metabolic process|secretion by cell|vesicle|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|cell-cell signaling|vesicle membrane|organic acid binding|protein dimerization activity|response to drug|cell communication|pyridoxal phosphate binding|establishment of localization in cell|regulation of neurotransmitter levels|cellular biosynthetic process|protein metabolic process|neurotransmitter transport|macromolecule modification|cytoplasmic vesicle|protein heterodimerization activity|cytoplasmic, membrane-bounded vesicle|protein modification process|clathrin-coated vesicle membrane|cellular amino acid catabolic process|carboxy-lyase activity|cellular amino acid biosynthetic process|membrane-bounded vesicle|cytoplasmic vesicle membrane|cellular protein metabolic process|carboxylic acid binding|secretion|gamma-aminobutyric acid metabolic process|neurotransmitter biosynthetic process|carboxylic acid catabolic process|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|coated vesicle|gamma-aminobutyric acid biosynthetic process|amino acid binding|carboxylic acid metabolic process|glutamate decarboxylase activity|cellular protein modification process|clathrin-coated vesicle|dicarboxylic acid metabolic process|glutamate binding|monocarboxylic acid metabolic process|dicarboxylic acid catabolic process|synaptic transmission|glutamate metabolic process|glutamate catabolic process|protein-pyridoxal-5-phosphate linkage|succinate metabolic process|glutamate decarboxylation to succinate K01580 glutamate decarboxylase[4.1.1.15] hsa01100|hsa04727|hsa04940|hsa00250|hsa00410|hsa00650|hsa00430 Metabolic pathways - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Type I diabetes mellitus - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human)|beta-Alanine metabolism - Homo sapiens (human)|Butanoate metabolism - Homo sapiens (human)|Taurine and hypotaurine metabolism - Homo sapiens (human) 2:170813213-170861151 292 346 450 184 175 167 1.41000259636486 1.5184249108716 1.9591364029374 0.796074282912507 0.693337820062235 0.755760107385279 1.62918797005795 0.748390736786674 1.12228945978659 4.0735299633817e-07 5.50276758039806e-06 UP ENSG00000171488 LRRC8C leucine-rich repeat containing 8 family member C [Source:HGNC Symbol;Acc:HGNC:25075] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0042175|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0043231|GO:0005737|GO:0005783|GO:0048869|GO:0016021|GO:0006811|GO:0030154|GO:0045444 developmental process|cell|membrane|cellular process|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|transport|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|cellular developmental process|integral component of membrane|ion transport|cell differentiation|fat cell differentiation - - - - 1:89633072-89769903 146 176 220 455 580 373 0.859555889893831 0.941703301366311 1.16777675385004 2.40010770735107 2.80167637633717 2.05806789537299 0.989678648370061 2.41995065968708 -1.28994557379876 4.09047191043616e-07 5.5231546094148e-06 DOWN ENSG00000138821 SLC39A8 solute carrier family 39 (zinc transporter), member 8 [Source:HGNC Symbol;Acc:HGNC:20862] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043227|GO:0071944|GO:0031224|GO:0005886|GO:0031090|GO:0006810|GO:0022891|GO:0055085|GO:0016021|GO:0006811|GO:0015075|GO:0034220|GO:0098655|GO:0006812|GO:0008324|GO:0022890|GO:0030001|GO:0070574|GO:0046873|GO:0006829 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|membrane-bounded organelle|cell periphery|intrinsic component of membrane|plasma membrane|organelle membrane|transport|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|ion transport|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|cation transport|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|cadmium ion transmembrane transport|metal ion transmembrane transporter activity|zinc II ion transport - - - - 4:102251041-102431258 145 159 219 531 553 342 1.34639847526919 1.34178412381595 1.8334242939531 4.41770945990003 4.21306536795757 2.97618083344653 1.50720229767941 3.86898522043471 -1.36008214827576 4.10478049696926e-07 5.53746574588885e-06 DOWN ENSG00000166133 RPUSD2 RNA pseudouridylate synthase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24180] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016853|GO:0019239|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0016866|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0003723|GO:0043412|GO:0009982|GO:0005739|GO:0010467|GO:0016070|GO:0006396|GO:0034660|GO:0009451|GO:0044822|GO:0006400|GO:0006399|GO:0001522|GO:0008033|GO:0031119 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|isomerase activity|deaminase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|intramolecular transferase activity|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|RNA binding|macromolecule modification|pseudouridine synthase activity|mitochondrion|gene expression|RNA metabolic process|RNA processing|ncRNA metabolic process|RNA modification|poly(A) RNA binding|tRNA modification|tRNA metabolic process|pseudouridine synthesis|tRNA processing|tRNA pseudouridine synthesis - - - - 15:40569300-40574943 452 479 361 214 210 175 7.52306545728149 7.24556426365462 5.41724927289572 3.1913067365596 2.86776205881437 2.72976148067273 6.72862633127728 2.92961009201557 1.19960333838983 4.10313172310742e-07 5.53746574588885e-06 UP ENSG00000112293 GPLD1 glycosylphosphatidylinositol specific phospholipase D1 [Source:HGNC Symbol;Acc:HGNC:4459] GO:0040011|GO:0032502|GO:0031012|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0003824|GO:1903561|GO:0019835|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0005578|GO:0006807|GO:0051050|GO:0071704|GO:0009056|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0097006|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005615|GO:0002684|GO:0016247|GO:0005622|GO:0002682|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0048514|GO:0060341|GO:0044262|GO:0051272|GO:0002757|GO:0042127|GO:0044255|GO:0046887|GO:0009888|GO:0006810|GO:0001568|GO:0010941|GO:0061178|GO:0007275|GO:0010632|GO:0048513|GO:0034641|GO:0016788|GO:0044281|GO:0032940|GO:0031982|GO:0019637|GO:0031325|GO:2000147|GO:0010942|GO:1900076|GO:0043231|GO:0010243|GO:0005774|GO:0005737|GO:0007267|GO:0032880|GO:0005975|GO:0051222|GO:0006928|GO:0042592|GO:0045919|GO:0045184|GO:0046883|GO:0019725|GO:0042493|GO:0010646|GO:0043085|GO:0050776|GO:0001525|GO:0009268|GO:0008104|GO:0007154|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0050778|GO:0035774|GO:0070062|GO:0001503|GO:0051649|GO:0009725|GO:0008219|GO:0017080|GO:0010634|GO:0008285|GO:0051047|GO:0050790|GO:0045833|GO:0010817|GO:0048869|GO:2000145|GO:0010035|GO:0034381|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0090207|GO:0032268|GO:0006109|GO:0045732|GO:0009743|GO:0090209|GO:0002040|GO:0090132|GO:0010983|GO:0051216|GO:0046486|GO:0007166|GO:0090276|GO:0033993|GO:0002793|GO:0001944|GO:0043412|GO:0072358|GO:0030163|GO:0051345|GO:0016042|GO:0048878|GO:0006066|GO:0044242|GO:0009308|GO:0051223|GO:0015031|GO:1901652|GO:0046889|GO:0005773|GO:0071417|GO:0006643|GO:0010038|GO:0030334|GO:0050994|GO:0001667|GO:0036211|GO:0070201|GO:0042886|GO:0035701|GO:0046470|GO:0055082|GO:0050714|GO:0002429|GO:0051046|GO:0006638|GO:0043434|GO:0034384|GO:0050995|GO:0009914|GO:0009306|GO:0005996|GO:0051247|GO:0071467|GO:0006508|GO:0002764|GO:0035773|GO:0032270|GO:0012501|GO:0014070|GO:0016298|GO:0006796|GO:0071241|GO:0044267|GO:0051174|GO:0042176|GO:0008610|GO:0019216|GO:0046903|GO:0071310|GO:0010594|GO:0046890|GO:0031328|GO:0051246|GO:0035690|GO:0030154|GO:0001501|GO:0061448|GO:0030335|GO:0043068|GO:0072359|GO:0032870|GO:0042578|GO:0043067|GO:0006644|GO:0034014|GO:0097305|GO:0010595|GO:0090277|GO:0070633|GO:0050796|GO:0071322|GO:0002790|GO:0004620|GO:0019318|GO:0016311|GO:0030073|GO:0010867|GO:0031401|GO:0001678|GO:0010866|GO:0043065|GO:0008081|GO:1901653|GO:0000323|GO:0010922|GO:0002062|GO:0030162|GO:0051592|GO:0097241|GO:0034284|GO:0045862|GO:0050708|GO:0046461|GO:0015833|GO:0002768|GO:0033619|GO:0071407|GO:0002042|GO:0010906|GO:0007167|GO:0006664|GO:0051044|GO:0032024|GO:0006576|GO:0071375|GO:0010631|GO:0042981|GO:0032868|GO:0006639|GO:0002430|GO:0006464|GO:0010897|GO:0071401|GO:0071396|GO:0046879|GO:0005765|GO:0006650|GO:0006915|GO:0010907|GO:0071248|GO:0033500|GO:0010921|GO:0006509|GO:0006470|GO:0071333|GO:0042593|GO:0035304|GO:0030072|GO:0010694|GO:0046488|GO:0005764|GO:0070723|GO:0071277|GO:0035307|GO:0006006|GO:0004630|GO:0046464|GO:0032869|GO:0006505|GO:0035306|GO:0036315|GO:0043542|GO:0035303|GO:0006641|GO:0007169|GO:0019432|GO:0071397|GO:0009749|GO:0004621|GO:0008286|GO:0019433|GO:0006507|GO:0043534 locomotion|developmental process|extracellular matrix|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|catalytic activity|extracellular vesicle|cytolysis|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|catabolic process|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|regulation of plasma lipoprotein particle levels|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|extracellular space|positive regulation of immune system process|channel regulator activity|intracellular|regulation of immune system process|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|cellular carbohydrate metabolic process|positive regulation of cellular component movement|immune response-activating signal transduction|regulation of cell proliferation|cellular lipid metabolic process|positive regulation of hormone secretion|tissue development|transport|blood vessel development|regulation of cell death|regulation of insulin secretion involved in cellular response to glucose stimulus|multicellular organism development|regulation of epithelial cell migration|animal organ development|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|secretion by cell|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|positive regulation of cell motility|positive regulation of cell death|regulation of cellular response to insulin stimulus|intracellular membrane-bounded organelle|response to organonitrogen compound|vacuolar membrane|cytoplasm|cell-cell signaling|regulation of protein localization|carbohydrate metabolic process|positive regulation of protein transport|movement of cell or subcellular component|homeostatic process|positive regulation of cytolysis|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|response to drug|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|angiogenesis|response to pH|protein localization|cell communication|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|positive regulation of immune response|positive regulation of insulin secretion involved in cellular response to glucose stimulus|extracellular exosome|ossification|establishment of localization in cell|response to hormone|cell death|sodium channel regulator activity|positive regulation of epithelial cell migration|negative regulation of cell proliferation|positive regulation of secretion|regulation of catalytic activity|negative regulation of lipid metabolic process|regulation of hormone levels|cellular developmental process|regulation of cell motility|response to inorganic substance|plasma lipoprotein particle clearance|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of triglyceride metabolic process|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|positive regulation of protein catabolic process|response to carbohydrate|negative regulation of triglyceride metabolic process|sprouting angiogenesis|epithelium migration|positive regulation of high-density lipoprotein particle clearance|cartilage development|glycerolipid metabolic process|cell surface receptor signaling pathway|regulation of peptide hormone secretion|response to lipid|positive regulation of peptide secretion|vasculature development|macromolecule modification|cardiovascular system development|protein catabolic process|positive regulation of hydrolase activity|lipid catabolic process|chemical homeostasis|alcohol metabolic process|cellular lipid catabolic process|amine metabolic process|regulation of protein transport|protein transport|response to peptide|positive regulation of lipid biosynthetic process|vacuole|cellular response to organonitrogen compound|membrane lipid metabolic process|response to metal ion|regulation of cell migration|regulation of lipid catabolic process|ameboidal-type cell migration|protein modification process|regulation of establishment of protein localization|amide transport|hematopoietic stem cell migration|phosphatidylcholine metabolic process|cellular chemical homeostasis|positive regulation of protein secretion|immune response-activating cell surface receptor signaling pathway|regulation of secretion|neutral lipid metabolic process|response to peptide hormone|high-density lipoprotein particle clearance|negative regulation of lipid catabolic process|hormone transport|protein secretion|monosaccharide metabolic process|positive regulation of protein metabolic process|cellular response to pH|proteolysis|immune response-regulating signaling pathway|insulin secretion involved in cellular response to glucose stimulus|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|lipase activity|phosphate-containing compound metabolic process|cellular response to inorganic substance|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|lipid biosynthetic process|regulation of lipid metabolic process|secretion|cellular response to organic substance|regulation of endothelial cell migration|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cellular response to drug|cell differentiation|skeletal system development|connective tissue development|positive regulation of cell migration|positive regulation of programmed cell death|circulatory system development|cellular response to hormone stimulus|phosphoric ester hydrolase activity|regulation of programmed cell death|phospholipid metabolic process|response to triglyceride|response to alcohol|positive regulation of endothelial cell migration|positive regulation of peptide hormone secretion|transepithelial transport|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|phospholipase activity|hexose metabolic process|dephosphorylation|insulin secretion|positive regulation of triglyceride biosynthetic process|positive regulation of protein modification process|cellular glucose homeostasis|regulation of triglyceride biosynthetic process|positive regulation of apoptotic process|phosphoric diester hydrolase activity|cellular response to peptide|lytic vacuole|positive regulation of phosphatase activity|chondrocyte differentiation|regulation of proteolysis|response to calcium ion|hematopoietic stem cell migration to bone marrow|response to monosaccharide|positive regulation of proteolysis|regulation of protein secretion|neutral lipid catabolic process|peptide transport|immune response-regulating cell surface receptor signaling pathway|membrane protein proteolysis|cellular response to organic cyclic compound|cell migration involved in sprouting angiogenesis|regulation of glucose metabolic process|enzyme linked receptor protein signaling pathway|glycolipid metabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of insulin secretion|cellular biogenic amine metabolic process|cellular response to peptide hormone stimulus|epithelial cell migration|regulation of apoptotic process|response to insulin|acylglycerol metabolic process|complement receptor mediated signaling pathway|cellular protein modification process|negative regulation of triglyceride catabolic process|cellular response to triglyceride|cellular response to lipid|hormone secretion|lysosomal membrane|glycerophospholipid metabolic process|apoptotic process|positive regulation of glucose metabolic process|cellular response to metal ion|carbohydrate homeostasis|regulation of phosphatase activity|membrane protein ectodomain proteolysis|protein dephosphorylation|cellular response to glucose stimulus|glucose homeostasis|regulation of protein dephosphorylation|peptide hormone secretion|positive regulation of alkaline phosphatase activity|phosphatidylinositol metabolic process|lysosome|response to cholesterol|cellular response to calcium ion|positive regulation of protein dephosphorylation|glucose metabolic process|phospholipase D activity|acylglycerol catabolic process|cellular response to insulin stimulus|GPI anchor metabolic process|positive regulation of dephosphorylation|cellular response to sterol|endothelial cell migration|regulation of dephosphorylation|triglyceride metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|triglyceride biosynthetic process|cellular response to cholesterol|response to glucose|glycosylphosphatidylinositol phospholipase D activity|insulin receptor signaling pathway|triglyceride catabolic process|GPI anchor release|blood vessel endothelial cell migration K01127 glycosylphosphatidylinositol phospholipase D[3.1.4.50] hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human) 6:24424565-24495205 21 14 14 61 63 77 0.241781284722463 0.146487993018713 0.145327592440428 0.629243442950326 0.595119476138184 0.83083285234992 0.177865623393868 0.685065257146143 -1.9454537174959 4.12965453879875e-07 5.56850526654462e-06 DOWN ENSG00000101096 NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 [Source:HGNC Symbol;Acc:HGNC:7776] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0008284|GO:0002757|GO:0042127|GO:0006949|GO:0045087|GO:0045595|GO:0006725|GO:0070661|GO:0048468|GO:0050867|GO:0051130|GO:1901360|GO:0060143|GO:0003676|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0061061|GO:0045597|GO:0043231|GO:0005737|GO:0000981|GO:0002218|GO:0001816|GO:0030529|GO:0006928|GO:0005667|GO:0002696|GO:0001775|GO:0009890|GO:0003682|GO:0042493|GO:0006139|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0016477|GO:0007165|GO:0050778|GO:0008134|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0000982|GO:0051249|GO:0005829|GO:0003677|GO:0051149|GO:0042113|GO:0010468|GO:0034645|GO:0032943|GO:0007166|GO:0044798|GO:0002758|GO:0010629|GO:1901741|GO:0042692|GO:0051252|GO:0010628|GO:0051147|GO:0051251|GO:0002429|GO:0031981|GO:0005654|GO:0002764|GO:0055001|GO:0035556|GO:0010467|GO:0001227|GO:0031328|GO:0046651|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0045089|GO:0006974|GO:0045088|GO:1901739|GO:0055002|GO:0015629|GO:0007520|GO:0000975|GO:0051153|GO:0045893|GO:0001078|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0002768|GO:1902679|GO:0050871|GO:0003690|GO:0050864|GO:0051146|GO:0042100|GO:0050851|GO:0019932|GO:0051155|GO:0050671|GO:0006351|GO:0006355|GO:0032946|GO:0045944|GO:0030890|GO:0006366|GO:0002223|GO:0010831|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0038093|GO:0014902|GO:0030888|GO:0010830|GO:0019722|GO:0014904|GO:0048016|GO:0000122|GO:0050853|GO:0000976|GO:0001012|GO:0038095|GO:0033173|GO:0001159|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of cell proliferation|immune response-activating signal transduction|regulation of cell proliferation|syncytium formation|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|leukocyte proliferation|cell development|positive regulation of cell activation|positive regulation of cellular component organization|organic cyclic compound metabolic process|positive regulation of syncytium formation by plasma membrane fusion|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|cytokine production|intracellular ribonucleoprotein complex|movement of cell or subcellular component|transcription factor complex|positive regulation of leukocyte activation|cell activation|negative regulation of biosynthetic process|chromatin binding|response to drug|nucleobase-containing compound metabolic process|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|cell migration|signal transduction|positive regulation of immune response|transcription factor binding|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of lymphocyte activation|cytosol|DNA binding|positive regulation of muscle cell differentiation|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|mononuclear cell proliferation|cell surface receptor signaling pathway|nuclear transcription factor complex|innate immune response-activating signal transduction|negative regulation of gene expression|positive regulation of myoblast fusion|muscle cell differentiation|regulation of RNA metabolic process|positive regulation of gene expression|regulation of muscle cell differentiation|positive regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|nuclear lumen|nucleoplasm|immune response-regulating signaling pathway|muscle cell development|intracellular signal transduction|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of innate immune response|cellular response to DNA damage stimulus|regulation of innate immune response|regulation of myoblast fusion|striated muscle cell development|actin cytoskeleton|myoblast fusion|regulatory region DNA binding|regulation of striated muscle cell differentiation|positive regulation of transcription, DNA-templated|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|immune response-regulating cell surface receptor signaling pathway|negative regulation of RNA biosynthetic process|positive regulation of B cell activation|double-stranded DNA binding|regulation of B cell activation|striated muscle cell differentiation|B cell proliferation|antigen receptor-mediated signaling pathway|second-messenger-mediated signaling|positive regulation of striated muscle cell differentiation|positive regulation of lymphocyte proliferation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of mononuclear cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of B cell proliferation|transcription from RNA polymerase II promoter|stimulatory C-type lectin receptor signaling pathway|positive regulation of myotube differentiation|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|Fc receptor signaling pathway|myotube differentiation|regulation of B cell proliferation|regulation of myotube differentiation|calcium-mediated signaling|myotube cell development|inositol phosphate-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|B cell receptor signaling pathway|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|Fc-epsilon receptor signaling pathway|calcineurin-NFAT signaling cascade|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K17332 nuclear factor of activated T-cells, cytoplasmic 2[-] hsa05166|hsa04360|hsa04022|hsa04921|hsa05161|hsa04310|hsa04650|hsa04380|hsa04660|hsa04662|hsa04370 HTLV-I infection - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human) 20:51386957-51562831 29 72 83 239 315 160 0.170196027289483 0.384027690176139 0.439177917932704 1.25674461847201 1.51680180748495 0.880034769658386 0.331133878466109 1.21786039853845 -1.87886224259041 4.16879159217078e-07 5.61620506284596e-06 DOWN ENSG00000185298 CCDC137 coiled-coil domain containing 137 [Source:HGNC Symbol;Acc:HGNC:33451] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 17:81666364-81673904 1537 1596 1273 764 872 549 20.4866318473564 19.3334569091438 15.2981642394335 9.12405661132854 9.53632576339861 6.85800976090887 18.3727509986446 8.50613071187867 1.11099273118336 4.16703323938078e-07 5.61620506284596e-06 UP ENSG00000118508 RAB32 RAB32, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9772] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0044877|GO:0050794|GO:0019882|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0043473|GO:0043227|GO:0009605|GO:0016787|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0006810|GO:0043168|GO:0048066|GO:0001882|GO:0031982|GO:0016817|GO:0022607|GO:0043231|GO:0005737|GO:0043482|GO:0012506|GO:0030742|GO:0032403|GO:0030666|GO:0045184|GO:0033059|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0000166|GO:0048869|GO:0005794|GO:0005768|GO:0006996|GO:0035651|GO:0005802|GO:0016050|GO:0035639|GO:0031410|GO:0035650|GO:0005769|GO:0001883|GO:0015031|GO:0016023|GO:0016818|GO:0046907|GO:0032549|GO:0090382|GO:0048753|GO:0031988|GO:0036461|GO:0005739|GO:0034613|GO:0070925|GO:0050931|GO:0035556|GO:0030659|GO:0017076|GO:0030154|GO:0030670|GO:0048757|GO:0032561|GO:0032438|GO:0030139|GO:0051169|GO:1903232|GO:0006886|GO:0016197|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0006913|GO:0017111|GO:0045335|GO:0042470|GO:0035646|GO:0003924 developmental process|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|antigen processing and presentation|intracellular organelle|ion binding|cellular localization|cellular component organization|pigmentation|membrane-bounded organelle|response to external stimulus|hydrolase activity|intracellular|protein binding|endomembrane system|organelle membrane|transport|anion binding|developmental pigmentation|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cellular pigment accumulation|vesicle membrane|GTP-dependent protein binding|protein complex binding|endocytic vesicle membrane|establishment of protein localization|cellular pigmentation|protein localization|cell communication|signal transduction|establishment of localization in cell|nucleotide binding|cellular developmental process|Golgi apparatus|endosome|organelle organization|AP-3 adaptor complex binding|trans-Golgi network|vesicle organization|purine ribonucleoside triphosphate binding|cytoplasmic vesicle|AP-1 adaptor complex binding|early endosome|purine nucleoside binding|protein transport|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|phagosome maturation|pigment granule organization|membrane-bounded vesicle|BLOC-2 complex binding|mitochondrion|cellular protein localization|organelle assembly|pigment cell differentiation|intracellular signal transduction|cytoplasmic vesicle membrane|purine nucleotide binding|cell differentiation|phagocytic vesicle membrane|pigment granule maturation|guanyl ribonucleotide binding|melanosome organization|endocytic vesicle|nuclear transport|melanosome assembly|intracellular protein transport|endosomal transport|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|nucleocytoplasmic transport|nucleoside-triphosphatase activity|phagocytic vesicle|melanosome|endosome to melanosome transport|GTPase activity - - - - 6:146543693-146554965 311 283 309 130 171 113 18.0765530990857 14.9493318923866 16.1930299542576 6.77013505837332 8.15489805842499 6.15546914169052 16.40630498191 7.02683408616294 1.2233036125955 4.17332554648286e-07 5.61724350156444e-06 UP ENSG00000228109 MFI2-AS1 MFI2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40373] - - - - - - 3:196999460-197004744 11 13 25 64 73 56 0.340526180702085 0.365761641875612 0.697775897479636 1.77516250783953 1.85418549314696 1.62472444569148 0.468021240019111 1.75135748222599 -1.90382768308123 4.17247470423302e-07 5.61724350156444e-06 DOWN ENSG00000170260 ZNF212 zinc finger protein 212 [Source:HGNC Symbol;Acc:HGNC:13004] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0008270 cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|identical protein binding|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 7:149239651-149255609 763 748 646 379 388 363 10.5004267149871 9.35544023433068 8.01547735724069 4.67325713236183 4.38109455981652 4.68185949268073 9.29044810218616 4.57873706161969 1.02079846393565 4.18875814446888e-07 5.63547479247292e-06 UP ENSG00000144048 DUSP11 dual specificity phosphatase 11 [Source:HGNC Symbol;Acc:HGNC:3066] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0006139|GO:0019538|GO:0003723|GO:0043412|GO:0036211|GO:0031981|GO:0005654|GO:0006796|GO:0044267|GO:0010467|GO:0016070|GO:0005634|GO:0042578|GO:0016311|GO:0006396|GO:0098507|GO:0016604|GO:0016791|GO:0044822|GO:0006464|GO:0016607|GO:0006470|GO:0098519|GO:0004721|GO:0035335|GO:0008138|GO:0004651|GO:0004725 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|protein metabolic process|RNA binding|macromolecule modification|protein modification process|nuclear lumen|nucleoplasm|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|RNA metabolic process|nucleus|phosphoric ester hydrolase activity|dephosphorylation|RNA processing|polynucleotide 5' dephosphorylation|nuclear body|phosphatase activity|poly(A) RNA binding|cellular protein modification process|nuclear speck|protein dephosphorylation|nucleotide phosphatase activity, acting on free nucleotides|phosphoprotein phosphatase activity|peptidyl-tyrosine dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|polynucleotide 5'-phosphatase activity|protein tyrosine phosphatase activity - - - - 2:73762184-73780157 213 233 227 572 599 471 3.59249991605212 3.57152403650001 3.45189572897196 8.64392690631392 8.28919361349602 7.44504888195701 3.53863989384136 8.12605646725565 -1.19936043495424 4.19849043272321e-07 5.6460240260594e-06 DOWN ENSG00000006606 CCL26 chemokine (C-C motif) ligand 26 [Source:HGNC Symbol;Acc:HGNC:10625] GO:0040011|GO:0002376|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0040012|GO:0006950|GO:0044089|GO:0071704|GO:0050900|GO:0006955|GO:0044237|GO:0048870|GO:0023051|GO:0040017|GO:0016043|GO:0009605|GO:0009893|GO:0005615|GO:0005515|GO:0019222|GO:0008284|GO:0051272|GO:0042127|GO:0006935|GO:0045087|GO:0051130|GO:0032535|GO:0005102|GO:0006952|GO:0031325|GO:0051128|GO:2000147|GO:0022607|GO:0032970|GO:0007267|GO:0009611|GO:0006928|GO:0009966|GO:0050673|GO:0010646|GO:0043085|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0030595|GO:0050790|GO:0072676|GO:0030029|GO:2000145|GO:0009967|GO:0019538|GO:0031334|GO:0043254|GO:0023014|GO:0010033|GO:0031323|GO:0006996|GO:0000165|GO:0050679|GO:1902533|GO:0032268|GO:0007186|GO:0005126|GO:0007166|GO:0032956|GO:0043412|GO:0007010|GO:0034097|GO:0051345|GO:0050727|GO:0005125|GO:0030334|GO:0001935|GO:0036211|GO:0006954|GO:0034341|GO:0060326|GO:0051247|GO:0050729|GO:0001664|GO:0050678|GO:0006461|GO:0030036|GO:0002548|GO:0032270|GO:0006796|GO:0035556|GO:0032273|GO:0033043|GO:0044267|GO:0051174|GO:0071310|GO:0051246|GO:0030832|GO:0030335|GO:1902531|GO:0048247|GO:0071621|GO:0010638|GO:0019221|GO:0031401|GO:0070555|GO:1990266|GO:0034622|GO:0071346|GO:0030838|GO:0043408|GO:0042379|GO:0043623|GO:0043087|GO:0016310|GO:0070371|GO:0030593|GO:0008064|GO:0001936|GO:0043547|GO:0051493|GO:0008009|GO:0043410|GO:0071345|GO:0001938|GO:0034612|GO:0006464|GO:0007015|GO:0051495|GO:0030833|GO:0051258|GO:0071347|GO:0048020|GO:0006468|GO:0071356|GO:0042325|GO:0070374|GO:0001932|GO:0001934|GO:0070372|GO:0070098|GO:0042327|GO:0008154|GO:0030041 locomotion|immune system process|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|leukocyte migration|immune response|cellular metabolic process|cell motility|regulation of signaling|positive regulation of locomotion|cellular component organization|response to external stimulus|positive regulation of metabolic process|extracellular space|protein binding|regulation of metabolic process|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|chemotaxis|innate immune response|positive regulation of cellular component organization|regulation of cellular component size|receptor binding|defense response|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|regulation of actin filament-based process|cell-cell signaling|response to wounding|movement of cell or subcellular component|regulation of signal transduction|epithelial cell proliferation|regulation of cell communication|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|cell migration|signal transduction|leukocyte chemotaxis|regulation of catalytic activity|lymphocyte migration|actin filament-based process|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|organelle organization|MAPK cascade|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|G-protein coupled receptor signaling pathway|cytokine receptor binding|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|macromolecule modification|cytoskeleton organization|response to cytokine|positive regulation of hydrolase activity|regulation of inflammatory response|cytokine activity|regulation of cell migration|endothelial cell proliferation|protein modification process|inflammatory response|response to interferon-gamma|cell chemotaxis|positive regulation of protein metabolic process|positive regulation of inflammatory response|G-protein coupled receptor binding|regulation of epithelial cell proliferation|protein complex assembly|actin cytoskeleton organization|monocyte chemotaxis|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|positive regulation of protein polymerization|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of protein metabolic process|regulation of actin filament length|positive regulation of cell migration|regulation of intracellular signal transduction|lymphocyte chemotaxis|granulocyte chemotaxis|positive regulation of organelle organization|cytokine-mediated signaling pathway|positive regulation of protein modification process|response to interleukin-1|neutrophil migration|cellular macromolecular complex assembly|cellular response to interferon-gamma|positive regulation of actin filament polymerization|regulation of MAPK cascade|chemokine receptor binding|cellular protein complex assembly|regulation of GTPase activity|phosphorylation|ERK1 and ERK2 cascade|neutrophil chemotaxis|regulation of actin polymerization or depolymerization|regulation of endothelial cell proliferation|positive regulation of GTPase activity|regulation of cytoskeleton organization|chemokine activity|positive regulation of MAPK cascade|cellular response to cytokine stimulus|positive regulation of endothelial cell proliferation|response to tumor necrosis factor|cellular protein modification process|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|protein polymerization|cellular response to interleukin-1|CCR chemokine receptor binding|protein phosphorylation|cellular response to tumor necrosis factor|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|chemokine-mediated signaling pathway|positive regulation of phosphorylation|actin polymerization or depolymerization|actin filament polymerization K05514 C-C motif chemokine, other[-] hsa04060|hsa04062 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human) 7:75769533-75789896 81 77 65 28 25 24 6.68578386589429 5.77614082234098 4.8371916654093 2.07071149915907 1.69304708841371 1.85655710538674 5.76637211788152 1.87343856431984 1.6219752722857 4.22083360215367e-07 5.67351491934695e-06 UP ENSG00000125378 BMP4 bone morphogenetic protein 4 [Source:HGNC Symbol;Acc:HGNC:1071] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0000003|GO:0002376|GO:0023052|GO:0042056|GO:0005623|GO:0048511|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0031128|GO:0040012|GO:0005578|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0042698|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0048870|GO:0023051|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0002262|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0005615|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:0022602|GO:1903829|GO:0005515|GO:0048856|GO:0048646|GO:0048609|GO:0019222|GO:2000137|GO:0042802|GO:0048514|GO:0007507|GO:0045137|GO:0060341|GO:0039706|GO:0008284|GO:0051272|GO:0051726|GO:0042127|GO:0007049|GO:1903706|GO:0048565|GO:0016337|GO:0008201|GO:0003014|GO:0035844|GO:0048286|GO:0006935|GO:0060685|GO:0009791|GO:0045595|GO:0060592|GO:0035239|GO:0060033|GO:0006725|GO:0060041|GO:0097094|GO:0061037|GO:0070661|GO:0001822|GO:0009888|GO:0048468|GO:0072200|GO:0045684|GO:0006810|GO:0022402|GO:0035295|GO:0051130|GO:0009612|GO:1901360|GO:0048839|GO:0001568|GO:0010941|GO:0002088|GO:0032835|GO:0007275|GO:0010632|GO:0030324|GO:0010524|GO:0045596|GO:0048513|GO:0070489|GO:0034101|GO:0051302|GO:0072028|GO:0005102|GO:0034641|GO:0043168|GO:0043062|GO:0030155|GO:0030900|GO:0061036|GO:0043270|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0090287|GO:0060687|GO:0007420|GO:0010942|GO:0070169|GO:0072102|GO:0098609|GO:0051098|GO:0061061|GO:0045786|GO:0045597|GO:0060740|GO:0048608|GO:0048635|GO:0001541|GO:0072111|GO:0035992|GO:0002089|GO:0005737|GO:0007389|GO:0001763|GO:0007267|GO:0072189|GO:0045992|GO:0061047|GO:0009611|GO:0060322|GO:0007423|GO:0032880|GO:0051222|GO:0060512|GO:0006928|GO:0009887|GO:0042592|GO:0031018|GO:0072050|GO:0001775|GO:0070368|GO:0021915|GO:0009966|GO:0048729|GO:0046983|GO:0048598|GO:0072006|GO:0048568|GO:0007548|GO:0050673|GO:0051782|GO:0045184|GO:0009890|GO:0019725|GO:0030323|GO:0006979|GO:0060548|GO:1901862|GO:0032388|GO:0044236|GO:0010646|GO:0006139|GO:0043085|GO:0007162|GO:0001525|GO:1900182|GO:0008104|GO:0046649|GO:0060235|GO:0050865|GO:0008406|GO:0007154|GO:0001704|GO:0044092|GO:0045778|GO:0055085|GO:0035148|GO:0051270|GO:0007276|GO:0016477|GO:0007165|GO:0030278|GO:0009968|GO:0048638|GO:0060438|GO:1901863|GO:0003279|GO:0001503|GO:0051649|GO:2000021|GO:0009725|GO:0008219|GO:0072049|GO:0060462|GO:0090316|GO:0048645|GO:0010634|GO:0060348|GO:0002695|GO:0008285|GO:0031016|GO:0048640|GO:0035993|GO:0072101|GO:0050790|GO:0060688|GO:0030030|GO:0051301|GO:0043086|GO:0001759|GO:0048869|GO:2000145|GO:0010035|GO:0021537|GO:0009967|GO:0060686|GO:0044249|GO:0030850|GO:0090184|GO:0019538|GO:0023014|GO:0005539|GO:0010033|GO:0031324|GO:0007281|GO:0031323|GO:0021536|GO:0048732|GO:0032411|GO:0072044|GO:0006996|GO:0072089|GO:0003205|GO:0060560|GO:0050768|GO:0000165|GO:0060425|GO:0050679|GO:0030501|GO:1902533|GO:0051249|GO:0032268|GO:0000902|GO:0042307|GO:0031175|GO:0060677|GO:0048705|GO:0045682|GO:0031344|GO:0044259|GO:0030879|GO:0051149|GO:0002040|GO:0010468|GO:0005126|GO:0090132|GO:0071773|GO:0034645|GO:0003156|GO:0048660|GO:0035990|GO:0032943|GO:0030218|GO:0051216|GO:0010453|GO:0055123|GO:0060113|GO:0010712|GO:0042733|GO:0007166|GO:0001654|GO:0002009|GO:0033993|GO:1903047|GO:0001944|GO:0043412|GO:0008585|GO:0072594|GO:0072164|GO:0061458|GO:0030097|GO:0072358|GO:0061005|GO:0030098|GO:0007417|GO:0032964|GO:0001655|GO:0010629|GO:0043583|GO:0072273|GO:0010720|GO:0007498|GO:0042692|GO:0072210|GO:0043069|GO:0002064|GO:0048878|GO:0072205|GO:0009798|GO:0061046|GO:0072110|GO:0051252|GO:0060541|GO:0035051|GO:0032386|GO:0048738|GO:0072284|GO:0034109|GO:0003007|GO:0010463|GO:0048754|GO:0010721|GO:0051223|GO:0072198|GO:0060795|GO:0045667|GO:0097066|GO:0015031|GO:0001709|GO:0005125|GO:0048659|GO:0061138|GO:0055006|GO:0031346|GO:0022612|GO:0031214|GO:0000904|GO:0009790|GO:0046545|GO:0001889|GO:0001656|GO:0010628|GO:0045844|GO:0060442|GO:0060502|GO:0030334|GO:0034767|GO:0051147|GO:0071731|GO:0001935|GO:0001667|GO:0048661|GO:0072175|GO:0051347|GO:0072095|GO:0036211|GO:0032269|GO:0000278|GO:0060840|GO:0030856|GO:0070201|GO:0060537|GO:0007369|GO:0042060|GO:0048844|GO:0046907|GO:0072190|GO:2000647|GO:0021871|GO:2000027|GO:0010159|GO:0048872|GO:0072001|GO:0006811|GO:0055082|GO:0001649|GO:0032330|GO:0045843|GO:0051250|GO:0072176|GO:0021983|GO:0060914|GO:0097168|GO:0022408|GO:0060440|GO:0003002|GO:0090194|GO:0022407|GO:0001707|GO:0033612|GO:0021532|GO:0003309|GO:0060485|GO:0035270|GO:0016331|GO:0050769|GO:0007346|GO:0072012|GO:0021978|GO:0090189|GO:0034599|GO:0010564|GO:0007159|GO:0051099|GO:0051247|GO:0045930|GO:0070848|GO:0031988|GO:0072077|GO:0034765|GO:0060433|GO:0070664|GO:0030858|GO:0006259|GO:0010092|GO:0050678|GO:0050680|GO:0055001|GO:1904591|GO:0060684|GO:0045669|GO:0061326|GO:0043269|GO:0001841|GO:0034613|GO:0032270|GO:0060993|GO:0042110|GO:0012501|GO:0032331|GO:0003197|GO:0014070|GO:0060429|GO:0000302|GO:0051054|GO:0006796|GO:1901342|GO:0032526|GO:0035556|GO:0072073|GO:0042476|GO:0033043|GO:0035108|GO:0044267|GO:0051174|GO:0007067|GO:0072161|GO:0010467|GO:0017038|GO:0050918|GO:0048562|GO:0003401|GO:0007399|GO:0060562|GO:0048701|GO:0071310|GO:0043586|GO:0045606|GO:0060349|GO:0060395|GO:0060439|GO:0032414|GO:1902532|GO:0010594|GO:0030198|GO:0031328|GO:0030510|GO:0051246|GO:0071260|GO:0046651|GO:0009059|GO:0010522|GO:0030154|GO:0072197|GO:0009755|GO:0001501|GO:0072104|GO:0060606|GO:0061448|GO:1901723|GO:0001823|GO:0060173|GO:0030335|GO:0061035|GO:0043068|GO:0007517|GO:0010714|GO:1903827|GO:0048546|GO:1902531|GO:0061312|GO:0016070|GO:0051928|GO:0008083|GO:0072359|GO:0072125|GO:0032870|GO:0060428|GO:0010557|GO:0042803|GO:0030282|GO:0051148|GO:0043067|GO:0072278|GO:0060513|GO:0048545|GO:0097305|GO:0048332|GO:0022898|GO:0006606|GO:0051960|GO:2000648|GO:0045165|GO:0010595|GO:0045995|GO:0072091|GO:0030500|GO:0010948|GO:0060363|GO:0034220|GO:0016202|GO:0043393|GO:0060197|GO:0048666|GO:0055020|GO:0030182|GO:0060602|GO:0003323|GO:0043401|GO:0055002|GO:0002521|GO:1903038|GO:0003158|GO:1904589|GO:0048706|GO:0042098|GO:0060571|GO:0055024|GO:0051153|GO:0060391|GO:0045893|GO:0048863|GO:0007500|GO:0035989|GO:0098655|GO:0010975|GO:0003130|GO:0060393|GO:0033365|GO:0033157|GO:0009792|GO:0031401|GO:0050863|GO:0048389|GO:0006260|GO:0061156|GO:0021904|GO:0042481|GO:0048739|GO:0045445|GO:0010001|GO:0043065|GO:0051169|GO:0001657|GO:0072178|GO:0030855|GO:0001843|GO:0043408|GO:0060350|GO:0051145|GO:0045892|GO:2000005|GO:0043010|GO:1902462|GO:0045620|GO:0007088|GO:0002062|GO:0055013|GO:0032774|GO:0060390|GO:0002066|GO:0050868|GO:0048333|GO:0006812|GO:1901021|GO:2001141|GO:0007224|GO:0001838|GO:0072078|GO:0061149|GO:0072179|GO:0030217|GO:0071363|GO:2000007|GO:0072163|GO:0016310|GO:0043627|GO:0001658|GO:0006605|GO:0045619|GO:1902679|GO:0032967|GO:0060402|GO:0070371|GO:0008544|GO:0090191|GO:0071383|GO:0097067|GO:0071407|GO:0045661|GO:0002043|GO:0045604|GO:0070486|GO:0048663|GO:0033085|GO:0016482|GO:0001936|GO:0003382|GO:0006886|GO:0032412|GO:0030509|GO:0070365|GO:0061333|GO:0007167|GO:0072201|GO:0045839|GO:0010862|GO:0033081|GO:2001012|GO:0061154|GO:0032092|GO:0009948|GO:2001259|GO:0009953|GO:0043410|GO:0072192|GO:0006275|GO:0072080|GO:0051146|GO:0032355|GO:0010631|GO:0048709|GO:0042981|GO:0009952|GO:0033077|GO:0050801|GO:0043066|GO:0001938|GO:0043409|GO:0001958|GO:0042475|GO:0048745|GO:0033673|GO:0002244|GO:0048704|GO:0048762|GO:0005160|GO:0060441|GO:0060503|GO:0001710|GO:0042306|GO:0034111|GO:0032945|GO:0033574|GO:0045603|GO:0060850|GO:0030099|GO:0045740|GO:1900180|GO:1904427|GO:0051150|GO:0014706|GO:0022008|GO:0060601|GO:0055007|GO:0006464|GO:0003338|GO:0007184|GO:0072097|GO:0045601|GO:2000826|GO:0072193|GO:0050767|GO:0043587|GO:0072283|GO:0035137|GO:0071396|GO:0033080|GO:0030326|GO:0051155|GO:0031960|GO:0060443|GO:0010976|GO:0045662|GO:0050672|GO:0071893|GO:0072138|GO:0043549|GO:0006351|GO:0035282|GO:0006915|GO:0006355|GO:0006873|GO:0030513|GO:0048592|GO:0032963|GO:0010464|GO:0033674|GO:0046824|GO:0045666|GO:0060681|GO:2000107|GO:0048715|GO:0045686|GO:0051384|GO:0035116|GO:1903533|GO:0000186|GO:1903169|GO:0045944|GO:0045446|GO:0006366|GO:0072112|GO:0002573|GO:0006913|GO:0045859|GO:1903507|GO:0045860|GO:0060231|GO:0006469|GO:0070700|GO:0006357|GO:0006261|GO:0048593|GO:0061151|GO:0006468|GO:0033088|GO:0043407|GO:0048699|GO:0014013|GO:0002320|GO:0045580|GO:1903506|GO:0045685|GO:0002068|GO:0045581|GO:0043405|GO:1904037|GO:0072498|GO:0042325|GO:1901341|GO:0003337|GO:0070374|GO:0061155|GO:0060272|GO:0001932|GO:0060675|GO:0042326|GO:0048747|GO:0042063|GO:2000727|GO:2000105|GO:1901019|GO:0072015|GO:0043009|GO:0042487|GO:0030001|GO:0001934|GO:0042130|GO:0042490|GO:0007178|GO:0051924|GO:0042129|GO:0001933|GO:0000122|GO:2001257|GO:0003139|GO:0070372|GO:0043542|GO:0048392|GO:0071593|GO:0045664|GO:0030003|GO:0048713|GO:0042327|GO:0034504|GO:0046822|GO:0060449|GO:0009913|GO:0072577|GO:0002067|GO:0051170|GO:0070588|GO:0030225|GO:2000353|GO:0030224|GO:0055065|GO:0071901|GO:0060389|GO:0033087|GO:0006875|GO:2000351|GO:1901339|GO:0071900|GO:0007182|GO:0032147|GO:0070228|GO:0070231|GO:0035883|GO:0006874|GO:0006816|GO:0055074|GO:0070233|GO:0070232|GO:0070242|GO:0051480|GO:0070243|GO:0070244|GO:0060401|GO:0007204 locomotion|developmental process|extracellular matrix|growth|reproduction|immune system process|signaling|chemoattractant activity|cell|rhythmic process|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|developmental induction|regulation of locomotion|proteinaceous extracellular matrix|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|ovulation cycle|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|cell motility|regulation of signaling|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|myeloid cell homeostasis|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|extracellular space|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|ovulation cycle process|positive regulation of cellular protein localization|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|negative regulation of cell proliferation involved in heart morphogenesis|identical protein binding|blood vessel morphogenesis|heart development|development of primary sexual characteristics|regulation of cellular localization|co-receptor binding|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of hemopoiesis|digestive tract development|single organismal cell-cell adhesion|heparin binding|renal system process|cloaca development|lung alveolus development|chemotaxis|regulation of prostatic bud formation|post-embryonic development|regulation of cell differentiation|mammary gland formation|tube morphogenesis|anatomical structure regression|cellular aromatic compound metabolic process|retina development in camera-type eye|craniofacial suture morphogenesis|negative regulation of cartilage development|leukocyte proliferation|kidney development|tissue development|cell development|negative regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of epidermis development|transport|cell cycle process|tube development|positive regulation of cellular component organization|response to mechanical stimulus|organic cyclic compound metabolic process|inner ear development|blood vessel development|regulation of cell death|lens development in camera-type eye|glomerulus development|multicellular organism development|regulation of epithelial cell migration|lung development|positive regulation of calcium ion transport into cytosol|negative regulation of cell differentiation|animal organ development|T cell aggregation|erythrocyte homeostasis|regulation of cell division|nephron morphogenesis|receptor binding|cellular nitrogen compound metabolic process|anion binding|extracellular structure organization|regulation of cell adhesion|forebrain development|positive regulation of cartilage development|positive regulation of ion transport|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|regulation of cellular response to growth factor stimulus|regulation of branching involved in prostate gland morphogenesis|brain development|positive regulation of cell death|positive regulation of biomineral tissue development|glomerulus morphogenesis|cell-cell adhesion|regulation of binding|muscle structure development|negative regulation of cell cycle|positive regulation of cell differentiation|prostate gland epithelium morphogenesis|reproductive structure development|negative regulation of muscle organ development|ovarian follicle development|cell proliferation involved in kidney development|tendon formation|lens morphogenesis in camera-type eye|cytoplasm|pattern specification process|morphogenesis of a branching structure|cell-cell signaling|ureter development|negative regulation of embryonic development|positive regulation of branching involved in lung morphogenesis|response to wounding|head development|sensory organ development|regulation of protein localization|positive regulation of protein transport|prostate gland morphogenesis|movement of cell or subcellular component|organ morphogenesis|homeostatic process|endocrine pancreas development|S-shaped body morphogenesis|cell activation|positive regulation of hepatocyte differentiation|neural tube development|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|nephron development|embryonic organ development|sex differentiation|epithelial cell proliferation|negative regulation of cell division|establishment of protein localization|negative regulation of biosynthetic process|cellular homeostasis|respiratory tube development|response to oxidative stress|negative regulation of cell death|negative regulation of muscle tissue development|positive regulation of intracellular transport|multicellular organism metabolic process|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|negative regulation of cell adhesion|angiogenesis|positive regulation of protein localization to nucleus|protein localization|lymphocyte activation|lens induction in camera-type eye|regulation of cell activation|gonad development|cell communication|formation of primary germ layer|negative regulation of molecular function|positive regulation of ossification|transmembrane transport|tube formation|regulation of cellular component movement|gamete generation|cell migration|signal transduction|regulation of ossification|negative regulation of signal transduction|regulation of developmental growth|trachea development|positive regulation of muscle tissue development|cardiac septum development|ossification|establishment of localization in cell|regulation of ion homeostasis|response to hormone|cell death|comma-shaped body morphogenesis|lung lobe development|positive regulation of intracellular protein transport|organ formation|positive regulation of epithelial cell migration|bone development|negative regulation of leukocyte activation|negative regulation of cell proliferation|pancreas development|negative regulation of developmental growth|deltoid tuberosity development|specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway|regulation of catalytic activity|regulation of morphogenesis of a branching structure|cell projection organization|cell division|negative regulation of catalytic activity|organ induction|cellular developmental process|regulation of cell motility|response to inorganic substance|telencephalon development|positive regulation of signal transduction|negative regulation of prostatic bud formation|cellular biosynthetic process|prostate gland development|positive regulation of kidney development|protein metabolic process|signal transduction by protein phosphorylation|glycosaminoglycan binding|response to organic substance|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|diencephalon development|gland development|positive regulation of transporter activity|collecting duct development|organelle organization|stem cell proliferation|cardiac chamber development|developmental growth involved in morphogenesis|negative regulation of neurogenesis|MAPK cascade|lung morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of bone mineralization|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cell morphogenesis|positive regulation of protein import into nucleus|neuron projection development|ureteric bud elongation|skeletal system morphogenesis|regulation of epidermis development|regulation of cell projection organization|multicellular organismal macromolecule metabolic process|mammary gland development|positive regulation of muscle cell differentiation|sprouting angiogenesis|regulation of gene expression|cytokine receptor binding|epithelium migration|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|regulation of organ formation|regulation of smooth muscle cell proliferation|tendon cell differentiation|mononuclear cell proliferation|erythrocyte differentiation|cartilage development|regulation of cell fate commitment|digestive system development|inner ear receptor cell differentiation|regulation of collagen metabolic process|embryonic digit morphogenesis|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|response to lipid|mitotic cell cycle process|vasculature development|macromolecule modification|female gonad development|establishment of protein localization to organelle|mesonephric tubule development|reproductive system development|hemopoiesis|cardiovascular system development|cell differentiation involved in kidney development|lymphocyte differentiation|central nervous system development|collagen biosynthetic process|urogenital system development|negative regulation of gene expression|ear development|metanephric nephron morphogenesis|positive regulation of cell development|mesoderm development|muscle cell differentiation|metanephric nephron development|negative regulation of programmed cell death|epithelial cell development|chemical homeostasis|metanephric collecting duct development|axis specification|regulation of branching involved in lung morphogenesis|glomerular mesangial cell proliferation|regulation of RNA metabolic process|respiratory system development|cardiocyte differentiation|regulation of intracellular transport|cardiac muscle tissue development|metanephric S-shaped body morphogenesis|homotypic cell-cell adhesion|heart morphogenesis|mesenchymal cell proliferation|branching morphogenesis of an epithelial tube|negative regulation of cell development|regulation of protein transport|mesenchymal cell proliferation involved in ureter development|cell fate commitment involved in formation of primary germ layer|regulation of osteoblast differentiation|response to thyroid hormone|protein transport|cell fate determination|cytokine activity|smooth muscle cell proliferation|morphogenesis of a branching epithelium|cardiac cell development|positive regulation of cell projection organization|gland morphogenesis|biomineral tissue development|cell morphogenesis involved in differentiation|embryo development|development of primary female sexual characteristics|liver development|metanephros development|positive regulation of gene expression|positive regulation of striated muscle tissue development|branching involved in prostate gland morphogenesis|epithelial cell proliferation involved in lung morphogenesis|regulation of cell migration|positive regulation of ion transmembrane transport|regulation of muscle cell differentiation|response to nitric oxide|endothelial cell proliferation|ameboidal-type cell migration|positive regulation of smooth muscle cell proliferation|epithelial tube formation|positive regulation of transferase activity|regulation of branch elongation involved in ureteric bud branching|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|artery development|regulation of epithelial cell differentiation|regulation of establishment of protein localization|muscle tissue development|gastrulation|wound healing|artery morphogenesis|intracellular transport|ureter urothelium development|negative regulation of stem cell proliferation|forebrain regionalization|regulation of organ morphogenesis|specification of organ position|homeostasis of number of cells|renal system development|ion transport|cellular chemical homeostasis|osteoblast differentiation|regulation of chondrocyte differentiation|negative regulation of striated muscle tissue development|negative regulation of lymphocyte activation|nephric duct development|pituitary gland development|heart formation|mesenchymal stem cell proliferation|negative regulation of cell-cell adhesion|trachea formation|regionalization|negative regulation of glomerulus development|regulation of cell-cell adhesion|mesoderm formation|receptor serine/threonine kinase binding|neural tube patterning|type B pancreatic cell differentiation|mesenchyme development|endocrine system development|morphogenesis of embryonic epithelium|positive regulation of neurogenesis|regulation of mitotic cell cycle|glomerulus vasculature development|telencephalon regionalization|regulation of branching involved in ureteric bud morphogenesis|cellular response to oxidative stress|regulation of cell cycle process|leukocyte cell-cell adhesion|positive regulation of binding|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|response to growth factor|membrane-bounded vesicle|renal vesicle morphogenesis|regulation of ion transmembrane transport|bronchus development|negative regulation of leukocyte proliferation|positive regulation of epithelial cell differentiation|DNA metabolic process|specification of organ identity|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|muscle cell development|positive regulation of protein import|epithelial-mesenchymal cell signaling|positive regulation of osteoblast differentiation|renal tubule development|regulation of ion transport|neural tube formation|cellular protein localization|positive regulation of cellular protein metabolic process|kidney morphogenesis|T cell activation|programmed cell death|negative regulation of chondrocyte differentiation|endocardial cushion development|response to organic cyclic compound|epithelium development|response to reactive oxygen species|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|regulation of vasculature development|response to retinoic acid|intracellular signal transduction|kidney epithelium development|odontogenesis|regulation of organelle organization|limb morphogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|mesenchymal cell differentiation involved in kidney development|gene expression|protein import|positive chemotaxis|embryonic organ morphogenesis|axis elongation|nervous system development|epithelial tube morphogenesis|embryonic cranial skeleton morphogenesis|cellular response to organic substance|tongue development|positive regulation of epidermal cell differentiation|bone morphogenesis|SMAD protein signal transduction|trachea morphogenesis|positive regulation of ion transmembrane transporter activity|negative regulation of intracellular signal transduction|regulation of endothelial cell migration|extracellular matrix organization|positive regulation of cellular biosynthetic process|regulation of BMP signaling pathway|regulation of protein metabolic process|cellular response to mechanical stimulus|lymphocyte proliferation|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|cell differentiation|ureter morphogenesis|hormone-mediated signaling pathway|skeletal system development|glomerular capillary formation|tube closure|connective tissue development|negative regulation of cell proliferation involved in kidney development|mesonephros development|limb development|positive regulation of cell migration|regulation of cartilage development|positive regulation of programmed cell death|muscle organ development|positive regulation of collagen metabolic process|regulation of cellular protein localization|digestive tract morphogenesis|regulation of intracellular signal transduction|BMP signaling pathway involved in heart development|RNA metabolic process|positive regulation of calcium ion transport|growth factor activity|circulatory system development|negative regulation of glomerular mesangial cell proliferation|cellular response to hormone stimulus|lung epithelium development|positive regulation of macromolecule biosynthetic process|protein homodimerization activity|bone mineralization|negative regulation of muscle cell differentiation|regulation of programmed cell death|metanephric comma-shaped body morphogenesis|prostatic bud formation|response to steroid hormone|response to alcohol|mesoderm morphogenesis|regulation of transmembrane transporter activity|protein import into nucleus|regulation of nervous system development|positive regulation of stem cell proliferation|cell fate commitment|positive regulation of endothelial cell migration|regulation of embryonic development|regulation of stem cell proliferation|regulation of bone mineralization|negative regulation of cell cycle process|cranial suture morphogenesis|ion transmembrane transport|regulation of striated muscle tissue development|regulation of protein binding|cloacal septation|neuron development|positive regulation of cardiac muscle fiber development|neuron differentiation|branch elongation of an epithelium|type B pancreatic cell development|steroid hormone mediated signaling pathway|striated muscle cell development|leukocyte differentiation|negative regulation of leukocyte cell-cell adhesion|endothelium development|regulation of protein import|embryonic skeletal system development|T cell proliferation|morphogenesis of an epithelial fold|regulation of cardiac muscle tissue development|regulation of striated muscle cell differentiation|positive regulation of SMAD protein import into nucleus|positive regulation of transcription, DNA-templated|stem cell differentiation|mesodermal cell fate determination|tendon development|cation transmembrane transport|regulation of neuron projection development|BMP signaling pathway involved in heart induction|regulation of pathway-restricted SMAD protein phosphorylation|protein localization to organelle|regulation of intracellular protein transport|embryo development ending in birth or egg hatching|positive regulation of protein modification process|regulation of T cell activation|intermediate mesoderm development|DNA replication|pulmonary artery morphogenesis|dorsal/ventral neural tube patterning|regulation of odontogenesis|cardiac muscle fiber development|myoblast differentiation|glial cell differentiation|positive regulation of apoptotic process|nuclear transport|ureteric bud development|nephric duct morphogenesis|epithelial cell differentiation|neural tube closure|regulation of MAPK cascade|endochondral bone morphogenesis|smooth muscle cell differentiation|negative regulation of transcription, DNA-templated|negative regulation of metanephric S-shaped body morphogenesis|camera-type eye development|positive regulation of mesenchymal stem cell proliferation|negative regulation of lymphocyte differentiation|regulation of mitotic nuclear division|chondrocyte differentiation|cardiac muscle cell development|RNA biosynthetic process|regulation of SMAD protein import into nucleus|columnar/cuboidal epithelial cell development|negative regulation of T cell activation|mesodermal cell differentiation|cation transport|positive regulation of calcium ion transmembrane transporter activity|regulation of RNA biosynthetic process|smoothened signaling pathway|embryonic epithelial tube formation|nephron tubule morphogenesis|BMP signaling pathway involved in ureter morphogenesis|nephric duct formation|T cell differentiation|cellular response to growth factor stimulus|negative regulation of metanephric comma-shaped body morphogenesis|mesonephric epithelium development|phosphorylation|response to estrogen|branching involved in ureteric bud morphogenesis|protein targeting|regulation of lymphocyte differentiation|negative regulation of RNA biosynthetic process|positive regulation of collagen biosynthetic process|calcium ion transport into cytosol|ERK1 and ERK2 cascade|epidermis development|negative regulation of branching involved in ureteric bud morphogenesis|cellular response to steroid hormone stimulus|cellular response to thyroid hormone stimulus|cellular response to organic cyclic compound|regulation of myoblast differentiation|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|regulation of epidermal cell differentiation|leukocyte aggregation|neuron fate commitment|negative regulation of T cell differentiation in thymus|cytosolic transport|regulation of endothelial cell proliferation|epithelial cell morphogenesis|intracellular protein transport|regulation of ion transmembrane transporter activity|BMP signaling pathway|hepatocyte differentiation|renal tubule morphogenesis|enzyme linked receptor protein signaling pathway|negative regulation of mesenchymal cell proliferation|negative regulation of mitotic nuclear division|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of T cell differentiation in thymus|mesenchymal cell differentiation involved in renal system development|endothelial tube morphogenesis|positive regulation of protein binding|anterior/posterior axis specification|positive regulation of cation channel activity|dorsal/ventral pattern formation|positive regulation of MAPK cascade|ureter epithelial cell differentiation|regulation of DNA replication|nephron tubule development|striated muscle cell differentiation|response to estradiol|epithelial cell migration|oligodendrocyte differentiation|regulation of apoptotic process|anterior/posterior pattern specification|T cell differentiation in thymus|ion homeostasis|negative regulation of apoptotic process|positive regulation of endothelial cell proliferation|negative regulation of MAPK cascade|endochondral ossification|odontogenesis of dentin-containing tooth|smooth muscle tissue development|negative regulation of kinase activity|hematopoietic progenitor cell differentiation|embryonic skeletal system morphogenesis|mesenchymal cell differentiation|transforming growth factor beta receptor binding|epithelial tube branching involved in lung morphogenesis|bud dilation involved in lung branching|mesodermal cell fate commitment|regulation of protein import into nucleus|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|response to testosterone|positive regulation of endothelial cell differentiation|regulation of transcription involved in cell fate commitment|myeloid cell differentiation|positive regulation of DNA replication|regulation of protein localization to nucleus|positive regulation of calcium ion transmembrane transport|regulation of smooth muscle cell differentiation|striated muscle tissue development|neurogenesis|lateral sprouting from an epithelium|cardiac muscle cell differentiation|cellular protein modification process|metanephros morphogenesis|SMAD protein import into nucleus|negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway|regulation of endothelial cell differentiation|regulation of heart morphogenesis|ureter smooth muscle cell differentiation|regulation of neurogenesis|tongue morphogenesis|metanephric renal vesicle morphogenesis|hindlimb morphogenesis|cellular response to lipid|immature T cell proliferation in thymus|embryonic limb morphogenesis|positive regulation of striated muscle cell differentiation|response to corticosteroid|mammary gland morphogenesis|positive regulation of neuron projection development|negative regulation of myoblast differentiation|negative regulation of lymphocyte proliferation|BMP signaling pathway involved in nephric duct formation|mesenchymal cell proliferation involved in ureteric bud development|regulation of kinase activity|transcription, DNA-templated|segmentation|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|positive regulation of BMP signaling pathway|eye morphogenesis|collagen metabolic process|regulation of mesenchymal cell proliferation|positive regulation of kinase activity|positive regulation of nucleocytoplasmic transport|positive regulation of neuron differentiation|branch elongation involved in ureteric bud branching|negative regulation of leukocyte apoptotic process|negative regulation of oligodendrocyte differentiation|negative regulation of glial cell differentiation|response to glucocorticoid|embryonic hindlimb morphogenesis|regulation of protein targeting|activation of MAPKK activity|regulation of calcium ion transmembrane transport|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|glomerular visceral epithelial cell differentiation|myeloid leukocyte differentiation|nucleocytoplasmic transport|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|mesenchymal to epithelial transition|negative regulation of protein kinase activity|BMP receptor binding|regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication|camera-type eye morphogenesis|BMP signaling pathway involved in renal system segmentation|protein phosphorylation|negative regulation of immature T cell proliferation in thymus|negative regulation of MAP kinase activity|generation of neurons|regulation of gliogenesis|lymphoid progenitor cell differentiation|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|regulation of glial cell differentiation|glandular epithelial cell development|negative regulation of T cell differentiation|regulation of MAP kinase activity|positive regulation of epithelial cell apoptotic process|embryonic skeletal joint development|regulation of phosphorylation|positive regulation of store-operated calcium channel activity|mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of ERK1 and ERK2 cascade|pulmonary artery endothelial tube morphogenesis|embryonic skeletal joint morphogenesis|regulation of protein phosphorylation|ureteric bud morphogenesis|negative regulation of phosphorylation|muscle fiber development|gliogenesis|positive regulation of cardiac muscle cell differentiation|positive regulation of DNA-dependent DNA replication|regulation of calcium ion transmembrane transporter activity|glomerular visceral epithelial cell development|chordate embryonic development|regulation of odontogenesis of dentin-containing tooth|metal ion transport|positive regulation of protein phosphorylation|negative regulation of T cell proliferation|mechanoreceptor differentiation|transmembrane receptor protein serine/threonine kinase signaling pathway|regulation of calcium ion transport|regulation of T cell proliferation|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|regulation of cation channel activity|secondary heart field specification|regulation of ERK1 and ERK2 cascade|endothelial cell migration|intermediate mesodermal cell differentiation|lymphocyte aggregation|regulation of neuron differentiation|cellular cation homeostasis|regulation of oligodendrocyte differentiation|positive regulation of phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|bud elongation involved in lung branching|epidermal cell differentiation|endothelial cell apoptotic process|glandular epithelial cell differentiation|nuclear import|calcium ion transmembrane transport|macrophage differentiation|positive regulation of endothelial cell apoptotic process|monocyte differentiation|metal ion homeostasis|negative regulation of protein serine/threonine kinase activity|pathway-restricted SMAD protein phosphorylation|negative regulation of immature T cell proliferation|cellular metal ion homeostasis|regulation of endothelial cell apoptotic process|regulation of store-operated calcium channel activity|regulation of protein serine/threonine kinase activity|common-partner SMAD protein phosphorylation|activation of protein kinase activity|regulation of lymphocyte apoptotic process|T cell apoptotic process|enteroendocrine cell differentiation|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|negative regulation of T cell apoptotic process|regulation of T cell apoptotic process|thymocyte apoptotic process|regulation of cytosolic calcium ion concentration|regulation of thymocyte apoptotic process|negative regulation of thymocyte apoptotic process|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K04662 bone morphogenetic protein 2/4[-] hsa05200|hsa04390|hsa04550|hsa04919|hsa04350|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 14:53949736-53958761 857 900 767 472 482 327 7.94514803891292 7.58304491749388 6.41107002471578 3.92067320301878 3.66636781849014 2.84117809852942 7.31308766037419 3.47607304001278 1.07302225870083 4.2633595942788e-07 5.72809798954092e-06 UP ENSG00000139668 WDFY2 WD repeat and FYVE domain containing 2 [Source:HGNC Symbol;Acc:HGNC:20482] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0045595|GO:0031982|GO:0031325|GO:0045597|GO:0043231|GO:0043169|GO:0005737|GO:0048869|GO:0019538|GO:0031323|GO:0005768|GO:0032268|GO:0046872|GO:0043412|GO:0005769|GO:0036211|GO:0045600|GO:0051247|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0045598|GO:0051246|GO:0030154|GO:0045444|GO:0031401|GO:0016310|GO:0006464|GO:0006468|GO:0042325|GO:0001932|GO:0001934|GO:0042327 developmental process|cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|regulation of developmental process|intracellular|protein binding|endomembrane system|regulation of metabolic process|regulation of cell differentiation|vesicle|positive regulation of cellular metabolic process|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular developmental process|protein metabolic process|regulation of cellular metabolic process|endosome|regulation of cellular protein metabolic process|metal ion binding|macromolecule modification|early endosome|protein modification process|positive regulation of fat cell differentiation|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of fat cell differentiation|regulation of protein metabolic process|cell differentiation|fat cell differentiation|positive regulation of protein modification process|phosphorylation|cellular protein modification process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation - - - - 13:51584455-51767707 141 200 312 554 603 566 0.602945794511426 0.77726154127759 1.20289071672982 2.12258724557911 2.11564591238314 2.26831438194084 0.861032684172945 2.1688491799677 -1.3327898252162 4.27897108353192e-07 5.74648685235097e-06 DOWN ENSG00000114473 IQCG IQ motif containing G [Source:HGNC Symbol;Acc:HGNC:25251] GO:0032502|GO:0000003|GO:0009987|GO:0005576|GO:0022414|GO:0005488|GO:1903561|GO:0044702|GO:0019953|GO:0003006|GO:0043227|GO:0032504|GO:0005515|GO:0048856|GO:0048609|GO:0048468|GO:0031982|GO:0048515|GO:0007276|GO:0070062|GO:0048869|GO:0007281|GO:0007286|GO:0048232|GO:0030154|GO:0007283 developmental process|reproduction|cellular process|extracellular region|reproductive process|binding|extracellular vesicle|single organism reproductive process|sexual reproduction|developmental process involved in reproduction|membrane-bounded organelle|multicellular organism reproduction|protein binding|anatomical structure development|multicellular organismal reproductive process|cell development|vesicle|spermatid differentiation|gamete generation|extracellular exosome|cellular developmental process|germ cell development|spermatid development|male gamete generation|cell differentiation|spermatogenesis - - - - 3:197889075-197960142 89 119 131 305 330 259 0.564626482211366 0.686118329333376 0.749299658505057 1.73367594653436 1.71772303778366 1.53992771947008 0.6666814900166 1.66377556792937 -1.31939125951834 4.35380219745433e-07 5.83738687529032e-06 DOWN ENSG00000233892 PAIP1P1 poly(A) binding protein interacting protein 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:18240] - - - - - - 6:30186798-30188614 25 24 24 4 5 6 1.4700236617851 1.28253969235051 1.27232460479417 0.210742652059301 0.24123017059343 0.330660838750383 1.34162931964326 0.260877887134371 2.36253955578309 4.35447865320276e-07 5.83738687529032e-06 UP ENSG00000205133 TRIQK triple QxxK/R motif containing [Source:HGNC Symbol;Acc:HGNC:27828] GO:0005623|GO:0016020|GO:0043229|GO:0042175|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0043231|GO:0005737|GO:0005783|GO:0016021 cell|membrane|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane - - - - 8:92883530-93017673 127 155 286 455 530 816 0.354844301875609 0.393591746530538 0.720466707452854 1.13904862755552 1.21500181027772 2.13674360454464 0.489634251953 1.49693134745929 -1.61223166857463 4.39788934768672e-07 5.89293485573785e-06 DOWN ENSG00000183665 TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:26091] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0006807|GO:0071704|GO:0044237|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0006139|GO:0043412|GO:0010467|GO:0016070|GO:0006396|GO:0034660|GO:0009451|GO:0006400|GO:0006399|GO:0008033 cellular process|metabolic process|binding|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|macromolecule modification|gene expression|RNA metabolic process|RNA processing|ncRNA metabolic process|RNA modification|tRNA modification|tRNA metabolic process|tRNA processing - - - - 8:124450820-124462150 614 624 532 319 298 281 12.0947912778168 11.1710769553481 9.44835865598802 5.63013610146305 4.81631921121514 5.18758604954109 10.9047422963843 5.21134712073976 1.06522741721304 4.43498794365341e-07 5.93731524976812e-06 UP ENSG00000188599 NPIPP1 nuclear pore complex interacting protein pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:35407] - - - - - - 16:15104312-15123498 75 92 65 16 30 29 2.58540406161478 2.88227670140078 2.02021113901353 0.49416643445288 0.848509381088909 0.936889944544362 2.49596396734303 0.75985525336205 1.71580057964742 4.45455282735631e-07 5.96083460815309e-06 UP ENSG00000108641 B9D1 B9 protein domain 1 [Source:HGNC Symbol;Acc:HGNC:24123] GO:0032502|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0050794|GO:0043229|GO:0038023|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0009888|GO:0007275|GO:0048513|GO:0022607|GO:0004888|GO:0005737|GO:0007423|GO:0032880|GO:0048598|GO:0072372|GO:0036038|GO:0036064|GO:0008104|GO:0007154|GO:0007165|GO:0035869|GO:0030030|GO:0048869|GO:0006996|GO:0000902|GO:0005829|GO:0005813|GO:0008158|GO:0042733|GO:0007166|GO:0001654|GO:0001944|GO:0072358|GO:0005815|GO:0009790|GO:0044782|GO:0030031|GO:0070925|GO:0060429|GO:0042384|GO:0035108|GO:0032990|GO:0030154|GO:0048858|GO:0060173|GO:0072359|GO:0005856|GO:0031513|GO:0060271|GO:0009792|GO:0030855|GO:0043010|GO:0007224|GO:0015630|GO:0030326|GO:0043009|GO:0060563|GO:0001701 developmental process|macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|regulation of cellular process|intracellular organelle|signaling receptor activity|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|tissue development|multicellular organism development|animal organ development|cellular component assembly|transmembrane signaling receptor activity|cytoplasm|sensory organ development|regulation of protein localization|embryonic morphogenesis|primary cilium|TCTN-B9D complex|ciliary basal body|protein localization|cell communication|signal transduction|ciliary transition zone|cell projection organization|cellular developmental process|organelle organization|cell morphogenesis|cytosol|centrosome|hedgehog receptor activity|embryonic digit morphogenesis|cell surface receptor signaling pathway|eye development|vasculature development|cardiovascular system development|microtubule organizing center|embryo development|cilium organization|cell projection assembly|organelle assembly|epithelium development|cilium assembly|limb morphogenesis|cell part morphogenesis|cell differentiation|cell projection morphogenesis|limb development|circulatory system development|cytoskeleton|nonmotile primary cilium|cilium morphogenesis|embryo development ending in birth or egg hatching|epithelial cell differentiation|camera-type eye development|smoothened signaling pathway|microtubule cytoskeleton|embryonic limb morphogenesis|chordate embryonic development|neuroepithelial cell differentiation|in utero embryonic development - - - - 17:19337554-19378182 93 84 148 284 333 284 1.07562451413496 0.882951827116062 1.54331012133725 2.94303222309232 3.16002048910121 3.07840896938941 1.16729548752942 3.06048722719431 -1.39059153807482 4.47635525503421e-07 5.98732570715911e-06 DOWN ENSG00000115866 DARS aspartyl-tRNA synthetase [Source:HGNC Symbol;Acc:HGNC:2678] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0006082|GO:0003676|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0031982|GO:0046483|GO:0022607|GO:0005737|GO:0006520|GO:0016810|GO:0006139|GO:0070062|GO:0000166|GO:0044249|GO:0019538|GO:0005829|GO:0034645|GO:0006518|GO:0003723|GO:0035639|GO:0001883|GO:0016811|GO:0032549|GO:0006461|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0009059|GO:0016070|GO:0016876|GO:0043043|GO:0043039|GO:0005524|GO:0034660|GO:0030554|GO:0006412|GO:0019752|GO:0044822|GO:0004812|GO:0004046|GO:0006418|GO:0006399|GO:0004815|GO:0006422 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|ligase activity|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|vesicle|heterocycle metabolic process|cellular component assembly|cytoplasm|cellular amino acid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|nucleobase-containing compound metabolic process|extracellular exosome|nucleotide binding|cellular biosynthetic process|protein metabolic process|cytosol|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|ribonucleoside binding|protein complex assembly|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|ligase activity, forming aminoacyl-tRNA and related compounds|peptide biosynthetic process|tRNA aminoacylation|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|translation|carboxylic acid metabolic process|poly(A) RNA binding|aminoacyl-tRNA ligase activity|aminoacylase activity|tRNA aminoacylation for protein translation|tRNA metabolic process|aspartate-tRNA ligase activity|aspartyl-tRNA aminoacylation K01876 aspartyl-tRNA synthetase[6.1.1.12] hsa00970 Aminoacyl-tRNA biosynthesis - Homo sapiens (human) 2:135906677-135986100 843 966 1243 2158 2430 2074 9.75800088278226 10.1622638942394 12.9723585022297 22.3811591252302 23.0785030038119 22.4994129466922 10.9642077597505 22.6530250252448 -1.04690214579933 4.5048746699415e-07 6.02277332720258e-06 DOWN ENSG00000223482 NUTM2A-AS1 NUTM2A antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:45161] - - - - - - 10:87203875-87342612 33 41 36 122 120 102 0.269208507520793 0.303979911186682 0.264784122192129 0.891731927711412 0.80320205281718 0.779839952661984 0.279324180299868 0.824924644396859 -1.56232186836406 4.51149177077721e-07 6.02892011301624e-06 DOWN ENSG00000153956 CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 [Source:HGNC Symbol;Acc:HGNC:1399] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0022857|GO:0050794|GO:0043229|GO:0043167|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0006810|GO:0098797|GO:0031982|GO:0030315|GO:0043231|GO:0043169|GO:0005737|GO:0042383|GO:0022891|GO:1902495|GO:0055085|GO:0005783|GO:0070062|GO:0016021|GO:0016528|GO:0046872|GO:0015267|GO:0006811|GO:0015075|GO:0005891|GO:1990454|GO:0034765|GO:0034702|GO:0043269|GO:0016529|GO:0034220|GO:0098655|GO:0005216|GO:0034703|GO:0006812|GO:0008324|GO:0005244|GO:0034704|GO:0022890|GO:0030001|GO:0051924|GO:0005261|GO:0005262|GO:0070588|GO:0022843|GO:0046873|GO:0006816|GO:0015085|GO:0005245 macromolecular complex|transporter activity|cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|transmembrane transporter activity|regulation of cellular process|intracellular organelle|ion binding|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|transport|plasma membrane protein complex|vesicle|T-tubule|intracellular membrane-bounded organelle|cation binding|cytoplasm|sarcolemma|substrate-specific transmembrane transporter activity|transmembrane transporter complex|transmembrane transport|endoplasmic reticulum|extracellular exosome|integral component of membrane|sarcoplasm|metal ion binding|channel activity|ion transport|ion transmembrane transporter activity|voltage-gated calcium channel complex|L-type voltage-gated calcium channel complex|regulation of ion transmembrane transport|ion channel complex|regulation of ion transport|sarcoplasmic reticulum|ion transmembrane transport|cation transmembrane transport|ion channel activity|cation channel complex|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|calcium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|regulation of calcium ion transport|cation channel activity|calcium channel activity|calcium ion transmembrane transport|voltage-gated cation channel activity|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity|voltage-gated calcium channel activity K04858 voltage-dependent calcium channel alpha-2/delta-1[-] hsa04010|hsa04921|hsa04261|hsa05414|hsa05410|hsa04260|hsa05412 MAPK signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 7:81946444-82443798 11 16 24 55 84 61 0.071477339969159 0.0944880427397677 0.140603205912859 0.320214102154863 0.44784298626897 0.371479339086314 0.102189529540595 0.379845475836716 -1.89416525445762 4.52903172396304e-07 6.04424287381281e-06 DOWN ENSG00000168907 PLA2G4F phospholipase A2 group IVF [Source:HGNC Symbol;Acc:HGNC:27396] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0031090|GO:0006575|GO:0044255|GO:0006810|GO:0006082|GO:0034641|GO:0016788|GO:0044281|GO:0031982|GO:0019637|GO:0043231|GO:0043169|GO:0005774|GO:0005737|GO:0006520|GO:0001726|GO:0006629|GO:0031256|GO:0031253|GO:0044249|GO:0010876|GO:0010033|GO:0009636|GO:0005829|GO:0006658|GO:0008654|GO:0046486|GO:0046872|GO:0016042|GO:0006066|GO:0044242|GO:0009308|GO:0006631|GO:0005773|GO:0006811|GO:0046470|GO:0097237|GO:0006869|GO:0032587|GO:0046677|GO:0014070|GO:0016298|GO:0006796|GO:0008610|GO:0046903|GO:0071310|GO:0046434|GO:0052689|GO:0006644|GO:0006690|GO:0004620|GO:0033559|GO:0009395|GO:0036152|GO:0004622|GO:0006820|GO:0015711|GO:0071236|GO:0000323|GO:0046474|GO:0004623|GO:0015908|GO:0071407|GO:0046942|GO:0006633|GO:0006576|GO:0036150|GO:0019752|GO:0036151|GO:0046456|GO:0046717|GO:0005765|GO:0006650|GO:0006636|GO:0015718|GO:0047498|GO:0046488|GO:0005764|GO:0032787|GO:0006693|GO:0015909|GO:0036149|GO:0050482|GO:0001516|GO:0036148 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|biosynthetic process|intracellular|protein binding|plasma membrane|organelle membrane|cellular modified amino acid metabolic process|cellular lipid metabolic process|transport|organic acid metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|organophosphate metabolic process|intracellular membrane-bounded organelle|cation binding|vacuolar membrane|cytoplasm|cellular amino acid metabolic process|ruffle|lipid metabolic process|leading edge membrane|cell projection membrane|cellular biosynthetic process|lipid localization|response to organic substance|response to toxic substance|cytosol|phosphatidylserine metabolic process|phospholipid biosynthetic process|glycerolipid metabolic process|metal ion binding|lipid catabolic process|alcohol metabolic process|cellular lipid catabolic process|amine metabolic process|fatty acid metabolic process|vacuole|ion transport|phosphatidylcholine metabolic process|cellular response to toxic substance|lipid transport|ruffle membrane|response to antibiotic|response to organic cyclic compound|lipase activity|phosphate-containing compound metabolic process|lipid biosynthetic process|secretion|cellular response to organic substance|organophosphate catabolic process|carboxylic ester hydrolase activity|phospholipid metabolic process|icosanoid metabolic process|phospholipase activity|unsaturated fatty acid metabolic process|phospholipid catabolic process|phosphatidylethanolamine acyl-chain remodeling|lysophospholipase activity|anion transport|organic anion transport|cellular response to antibiotic|lytic vacuole|glycerophospholipid biosynthetic process|phospholipase A2 activity|fatty acid transport|cellular response to organic cyclic compound|carboxylic acid transport|fatty acid biosynthetic process|cellular biogenic amine metabolic process|phosphatidylserine acyl-chain remodeling|carboxylic acid metabolic process|phosphatidylcholine acyl-chain remodeling|icosanoid biosynthetic process|acid secretion|lysosomal membrane|glycerophospholipid metabolic process|unsaturated fatty acid biosynthetic process|monocarboxylic acid transport|calcium-dependent phospholipase A2 activity|phosphatidylinositol metabolic process|lysosome|monocarboxylic acid metabolic process|prostaglandin metabolic process|long-chain fatty acid transport|phosphatidylinositol acyl-chain remodeling|arachidonic acid secretion|prostaglandin biosynthetic process|phosphatidylglycerol acyl-chain remodeling K16342 cytosolic phospholipase A2[3.1.1.4] hsa01100|hsa04010|hsa04014|hsa04921|hsa04072|hsa04611|hsa04270|hsa04724|hsa04726|hsa05231|hsa04750|hsa00564|hsa04666|hsa04912|hsa04664|hsa00590|hsa04370|hsa04730|hsa04913|hsa00565|hsa00591|hsa00592 Metabolic pathways - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|Ovarian steroidogenesis - Homo sapiens (human)|Ether lipid metabolism - Homo sapiens (human)|Linoleic acid metabolism - Homo sapiens (human)|alpha-Linolenic acid metabolism - Homo sapiens (human) 15:42139034-42156636 5 1 7 20 39 35 0.0335388721046154 0.00609877932267584 0.0423300767874195 0.120192768246221 0.21462903592432 0.22001547081564 0.0273225760715702 0.184945758328727 -2.75893679542176 4.52881315043042e-07 6.04424287381281e-06 DOWN ENSG00000267575 CTC-459F4.3 - - - - - - - 19:27793463-27918863 273 377 310 146 171 103 2.22504403821399 2.79252717000427 2.2779884931618 1.06616936162434 1.14350857669123 0.786758609852493 2.43185323379335 0.998812182722688 1.28377083912921 4.52770076430186e-07 6.04424287381281e-06 UP ENSG00000113645 WWC1 WW and C2 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:29435] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0060090|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0032947|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0000989|GO:0045926|GO:0043227|GO:0071944|GO:0040008|GO:0023057|GO:0009893|GO:0031252|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0060341|GO:0003712|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0046620|GO:0031325|GO:0046483|GO:0046621|GO:0035265|GO:0043231|GO:0019899|GO:0005737|GO:0001726|GO:0006928|GO:0009966|GO:0009890|GO:0030674|GO:0010646|GO:0006139|GO:0007163|GO:0007154|GO:0016477|GO:0007165|GO:0009968|GO:0048638|GO:0051649|GO:0031256|GO:0048640|GO:0031253|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0003713|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0043412|GO:0010629|GO:0051252|GO:0032386|GO:0036211|GO:0046907|GO:0030010|GO:0051247|GO:0048471|GO:0032587|GO:0019900|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:1902532|GO:0051246|GO:0009059|GO:1902531|GO:0016070|GO:0005634|GO:0031401|GO:0043408|GO:0045892|GO:0032774|GO:0035331|GO:2001141|GO:0016310|GO:1902679|GO:0035329|GO:0043410|GO:0035330|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0001934|GO:0000122|GO:0042327 locomotion|developmental process|growth|macromolecular complex|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|binding, bridging|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|protein complex scaffold|cellular metabolic process|cellular localization|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|negative regulation of growth|membrane-bounded organelle|cell periphery|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|protein complex|regulation of metabolic process|regulation of cellular localization|transcription cofactor activity|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|regulation of organ growth|positive regulation of cellular metabolic process|heterocycle metabolic process|negative regulation of organ growth|organ growth|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|ruffle|movement of cell or subcellular component|regulation of signal transduction|negative regulation of biosynthetic process|protein binding, bridging|regulation of cell communication|nucleobase-containing compound metabolic process|establishment or maintenance of cell polarity|cell communication|cell migration|signal transduction|negative regulation of signal transduction|regulation of developmental growth|establishment of localization in cell|leading edge membrane|negative regulation of developmental growth|cell projection membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription coactivator activity|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|regulation of intracellular transport|protein modification process|intracellular transport|establishment of cell polarity|positive regulation of protein metabolic process|perinuclear region of cytoplasm|ruffle membrane|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|negative regulation of intracellular signal transduction|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|nucleus|positive regulation of protein modification process|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|RNA biosynthetic process|negative regulation of hippo signaling|regulation of RNA biosynthetic process|phosphorylation|negative regulation of RNA biosynthetic process|hippo signaling|positive regulation of MAPK cascade|regulation of hippo signaling|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of phosphorylation K16685 protein KIBRA[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) 5:168291651-168472303 376 436 695 1221 1245 1050 1.66784214125159 1.75765501698063 2.77949319881642 4.85266346305621 4.53110347890773 4.36500763301272 2.06833011901621 4.58292485832555 -1.14780216387017 4.56102141449144e-07 6.08421507186003e-06 DOWN ENSG00000084693 AGBL5 ATP/GTP binding protein-like 5 [Source:HGNC Symbol;Acc:HGNC:26147] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0030496|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0008092|GO:0019538|GO:0015631|GO:0005829|GO:0046872|GO:0043412|GO:0036211|GO:0006508|GO:0044267|GO:0005856|GO:0005634|GO:0005819|GO:0008237|GO:0072686|GO:0015630|GO:0008238|GO:0046914|GO:0006464|GO:0004180|GO:0018193|GO:0008235|GO:0008270|GO:0004181|GO:0035608|GO:0035611 cell|cellular process|metabolic process|binding|catalytic activity|midbody|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|cytoskeletal protein binding|protein metabolic process|tubulin binding|cytosol|metal ion binding|macromolecule modification|protein modification process|proteolysis|cellular protein metabolic process|cytoskeleton|nucleus|spindle|metallopeptidase activity|mitotic spindle|microtubule cytoskeleton|exopeptidase activity|transition metal ion binding|cellular protein modification process|carboxypeptidase activity|peptidyl-amino acid modification|metalloexopeptidase activity|zinc ion binding|metallocarboxypeptidase activity|protein deglutamylation|protein branching point deglutamylation - - - - 2:27042364-27070622 614 657 790 1476 1564 1437 5.31413134450511 5.16784386279292 6.16460615567465 11.4458579047226 11.1062907320135 11.6560141876116 5.54886045432423 11.4027209414492 -1.03911469751977 4.56387921449923e-07 6.08530817640286e-06 DOWN ENSG00000060982 BCAT1 branched chain amino-acid transaminase 1, cytosolic [Source:HGNC Symbol;Acc:HGNC:976] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0008283|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0042802|GO:0007049|GO:0022402|GO:0006082|GO:0034641|GO:0044281|GO:0005737|GO:0006520|GO:0044249|GO:0005829|GO:1903047|GO:0044770|GO:0009081|GO:0000278|GO:0008483|GO:0009063|GO:0008652|GO:0009083|GO:0009082|GO:0044772|GO:0046395|GO:0004084|GO:0019752|GO:0052654|GO:0052655|GO:0000082|GO:0052656 cell|cellular process|metabolic process|binding|catalytic activity|cell proliferation|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|identical protein binding|cell cycle|cell cycle process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|cytoplasm|cellular amino acid metabolic process|cellular biosynthetic process|cytosol|mitotic cell cycle process|cell cycle phase transition|branched-chain amino acid metabolic process|mitotic cell cycle|transaminase activity|cellular amino acid catabolic process|cellular amino acid biosynthetic process|branched-chain amino acid catabolic process|branched-chain amino acid biosynthetic process|mitotic cell cycle phase transition|carboxylic acid catabolic process|branched-chain-amino-acid transaminase activity|carboxylic acid metabolic process|L-leucine transaminase activity|L-valine transaminase activity|G1/S transition of mitotic cell cycle|L-isoleucine transaminase activity K00826 branched-chain amino acid aminotransferase[2.6.1.42] hsa01100|hsa01230|hsa00280|hsa00270|hsa00770|hsa01210|hsa00290 Metabolic pathways - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Valine, leucine and isoleucine degradation - Homo sapiens (human)|Cysteine and methionine metabolism - Homo sapiens (human)|Pantothenate and CoA biosynthesis - Homo sapiens (human)|2-Oxocarboxylic acid metabolism - Homo sapiens (human)|Valine, leucine and isoleucine biosynthesis - Homo sapiens (human) 12:24810022-24949459 20 14 42 117 96 92 0.0686033129624769 0.0436437895988252 0.129890962831356 0.359583713570823 0.270181692987662 0.295755225439069 0.0807126884642194 0.308506877332518 -1.93443525496185 4.63280266931924e-07 6.17445048615431e-06 DOWN ENSG00000070366 SMG6 SMG6 nonsense mediated mRNA decay factor [Source:HGNC Symbol;Acc:HGNC:17809] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0032205|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0071166|GO:0043021|GO:0034641|GO:0016788|GO:0032204|GO:0046483|GO:0051128|GO:0043231|GO:0000723|GO:0043169|GO:0019899|GO:0005737|GO:0030529|GO:0042592|GO:0035145|GO:0006139|GO:0051649|GO:0006403|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0005829|GO:0003677|GO:0007004|GO:0034645|GO:0051053|GO:1904354|GO:0046872|GO:0003723|GO:0010833|GO:0070182|GO:0044265|GO:0046907|GO:0031981|GO:0004518|GO:0006259|GO:0005694|GO:0005697|GO:0050658|GO:0006796|GO:0033043|GO:0051174|GO:0010467|GO:0019439|GO:1904356|GO:0009059|GO:0016233|GO:0016070|GO:0005634|GO:0006401|GO:0016311|GO:0090501|GO:0032200|GO:0006260|GO:0000781|GO:2001251|GO:0051028|GO:0051169|GO:0043565|GO:0033044|GO:0000333|GO:0016071|GO:0006275|GO:0004519|GO:0004540|GO:0070034|GO:0090305|GO:0006406|GO:0006405|GO:0032210|GO:0006278|GO:0006913|GO:0042162|GO:0006402|GO:0090502|GO:0004521|GO:0035303|GO:0051168|GO:0000956|GO:0000184 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|negative regulation of telomere maintenance|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|ribonucleoprotein complex localization|ribonucleoprotein complex binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|regulation of telomere maintenance|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|telomere maintenance|cation binding|enzyme binding|cytoplasm|intracellular ribonucleoprotein complex|homeostatic process|exon-exon junction complex|nucleobase-containing compound metabolic process|establishment of localization in cell|RNA localization|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|cytosol|DNA binding|telomere maintenance via telomerase|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|negative regulation of telomere capping|metal ion binding|RNA binding|telomere maintenance via telomere lengthening|DNA polymerase binding|cellular macromolecule catabolic process|intracellular transport|nuclear lumen|nuclease activity|DNA metabolic process|chromosome|telomerase holoenzyme complex|RNA transport|phosphate-containing compound metabolic process|regulation of organelle organization|regulation of phosphorus metabolic process|gene expression|aromatic compound catabolic process|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|telomere capping|RNA metabolic process|nucleus|RNA catabolic process|dephosphorylation|RNA phosphodiester bond hydrolysis|telomere organization|DNA replication|chromosome, telomeric region|negative regulation of chromosome organization|mRNA transport|nuclear transport|sequence-specific DNA binding|regulation of chromosome organization|telomerase catalytic core complex|mRNA metabolic process|regulation of DNA replication|endonuclease activity|ribonuclease activity|telomerase RNA binding|nucleic acid phosphodiester bond hydrolysis|mRNA export from nucleus|RNA export from nucleus|regulation of telomere maintenance via telomerase|RNA-dependent DNA replication|nucleocytoplasmic transport|telomeric DNA binding|mRNA catabolic process|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|regulation of dephosphorylation|nuclear export|nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay K11124 protein SMG6 [EC:3.1.-.-][-] hsa03015 mRNA surveillance pathway - Homo sapiens (human) 17:2059839-2303771 175 234 382 639 731 664 0.62482014607281 0.759298843453577 1.22968984088234 2.04416445963095 2.14142495150654 2.22184712484031 0.871269610136242 2.13581217865927 -1.29359365536407 4.70045823406817e-07 6.25903122746973e-06 DOWN ENSG00000100426 ZBED4 zinc finger, BED-type containing 4 [Source:HGNC Symbol;Acc:HGNC:20721] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0043169|GO:0005737|GO:0046983|GO:0003677|GO:0046872|GO:0005634 cell|binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein dimerization activity|DNA binding|metal ion binding|nucleus - - - - 22:49853842-49890078 480 611 659 1208 1365 1261 4.92582336832914 5.69847265268669 6.09729216857646 11.1071384332764 11.4931194223298 12.1277864379969 5.5738627298641 11.5760147645344 -1.05438928899382 4.70040772654505e-07 6.25903122746973e-06 DOWN ENSG00000260461 RP11-541N10.3 - - - - - - - 10:103877374-103879761 8 1 7 40 25 52 0.236963359960352 0.0269337214141287 0.186940112981627 1.0616289723875 0.607596882232222 1.44358536856941 0.150279064785369 1.03760374106304 -2.78753963825187 4.71133552512684e-07 6.27071826870873e-06 DOWN ENSG00000105127 AKAP8 A-kinase anchoring protein 8 [Source:HGNC Symbol;Acc:HGNC:378] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0007049|GO:0022402|GO:0003676|GO:0043231|GO:0043169|GO:0005737|GO:0051018|GO:0007154|GO:0007165|GO:0007059|GO:0005794|GO:0006996|GO:0051276|GO:0003677|GO:0000819|GO:0046872|GO:0003723|GO:1903047|GO:0034237|GO:0000278|GO:0031981|GO:0005654|GO:0005739|GO:0016363|GO:0005694|GO:0007067|GO:0034399|GO:0005634|GO:0030261|GO:0000793|GO:0045120|GO:0003690|GO:0007076|GO:0000070|GO:0046914|GO:0044822|GO:0071103|GO:0006323|GO:0001939|GO:0008270 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|cell cycle|cell cycle process|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein kinase A binding|cell communication|signal transduction|chromosome segregation|Golgi apparatus|organelle organization|chromosome organization|DNA binding|sister chromatid segregation|metal ion binding|RNA binding|mitotic cell cycle process|protein kinase A regulatory subunit binding|mitotic cell cycle|nuclear lumen|nucleoplasm|mitochondrion|nuclear matrix|chromosome|mitotic nuclear division|nuclear periphery|nucleus|chromosome condensation|condensed chromosome|pronucleus|double-stranded DNA binding|mitotic chromosome condensation|mitotic sister chromatid segregation|transition metal ion binding|poly(A) RNA binding|DNA conformation change|DNA packaging|female pronucleus|zinc ion binding - - - - 19:15353385-15379798 1767 2024 1360 895 923 774 17.8458029072582 18.5776244940011 12.3837637452175 8.09879662990602 7.64837617982323 7.32603996953746 16.2690637154923 7.69107092642224 1.0808748240934 4.72076921355742e-07 6.2804743360759e-06 UP ENSG00000185219 ZNF445 zinc finger protein 445 [Source:HGNC Symbol;Acc:HGNC:21018] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0001071|GO:0005488|GO:1903561|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0070062|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|extracellular region|metabolic process|nucleic acid binding transcription factor activity|binding|extracellular vesicle|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|extracellular exosome|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 3:44431720-44477670 594 717 673 257 440 284 1.38243264982326 1.51655017488158 1.41217107475 0.535906235281771 0.840191389116857 0.619449537960966 1.43705129981828 0.665182387453198 1.11128968910803 4.76623317769932e-07 6.33813475666083e-06 UP ENSG00000164930 FZD6 frizzled class receptor 6 [Source:HGNC Symbol;Acc:HGNC:4044] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009986|GO:0044237|GO:0045177|GO:0038023|GO:0023051|GO:0009653|GO:0043227|GO:0071944|GO:0023057|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0050817|GO:0035239|GO:0006725|GO:0009888|GO:0007164|GO:0035295|GO:1901360|GO:0048839|GO:0016324|GO:0007275|GO:0048513|GO:0034641|GO:0031982|GO:0046483|GO:0007420|GO:0005887|GO:0043231|GO:0019899|GO:0004888|GO:0001942|GO:0005737|GO:0009611|GO:0060322|GO:0007423|GO:0012506|GO:0009887|GO:0001775|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0009890|GO:0030901|GO:0010646|GO:0006139|GO:0031226|GO:0007154|GO:0044092|GO:0035148|GO:0007165|GO:0009968|GO:0035878|GO:0061351|GO:0017147|GO:0016327|GO:0016021|GO:0044249|GO:0031324|GO:0031323|GO:0050878|GO:0051090|GO:0030111|GO:0007186|GO:0010468|GO:0034645|GO:0030168|GO:0030178|GO:0042733|GO:0007166|GO:0002009|GO:0007417|GO:0031410|GO:0010629|GO:0043583|GO:0033278|GO:0022405|GO:0007596|GO:0051252|GO:0009790|GO:0001736|GO:0016023|GO:0072175|GO:0042060|GO:2000027|GO:0035880|GO:0042472|GO:0016331|GO:0007599|GO:0031988|GO:0043433|GO:0043588|GO:0001841|GO:0060429|GO:0030659|GO:0035108|GO:0010467|GO:0048562|GO:0007399|GO:0060562|GO:0009059|GO:0060606|GO:0060173|GO:0016070|GO:0004930|GO:0044389|GO:0042633|GO:0042813|GO:0031625|GO:0016055|GO:0009792|GO:0090090|GO:0001843|GO:0060828|GO:0045892|GO:0032774|GO:2001141|GO:0001838|GO:1902679|GO:0008544|GO:0090175|GO:0042471|GO:0030326|GO:0006351|GO:0006355|GO:0098773|GO:0001738|GO:0035567|GO:1903507|GO:1903506|GO:0060070|GO:0043009|GO:0060071 developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cell surface|cellular metabolic process|apical part of cell|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|negative regulation of signaling|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|coagulation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|establishment of tissue polarity|tube development|organic cyclic compound metabolic process|inner ear development|apical plasma membrane|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|brain development|integral component of plasma membrane|intracellular membrane-bounded organelle|enzyme binding|transmembrane signaling receptor activity|hair follicle development|cytoplasm|response to wounding|head development|sensory organ development|vesicle membrane|organ morphogenesis|cell activation|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|midbrain development|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|cell communication|negative regulation of molecular function|tube formation|signal transduction|negative regulation of signal transduction|nail development|neural precursor cell proliferation|Wnt-protein binding|apicolateral plasma membrane|integral component of membrane|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|regulation of sequence-specific DNA binding transcription factor activity|regulation of Wnt signaling pathway|G-protein coupled receptor signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|platelet activation|negative regulation of Wnt signaling pathway|embryonic digit morphogenesis|cell surface receptor signaling pathway|morphogenesis of an epithelium|central nervous system development|cytoplasmic vesicle|negative regulation of gene expression|ear development|cell proliferation in midbrain|hair cycle process|blood coagulation|regulation of RNA metabolic process|embryo development|establishment of planar polarity|cytoplasmic, membrane-bounded vesicle|epithelial tube formation|wound healing|regulation of organ morphogenesis|embryonic nail plate morphogenesis|inner ear morphogenesis|morphogenesis of embryonic epithelium|hemostasis|membrane-bounded vesicle|negative regulation of sequence-specific DNA binding transcription factor activity|skin development|neural tube formation|epithelium development|cytoplasmic vesicle membrane|limb morphogenesis|gene expression|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|macromolecule biosynthetic process|tube closure|limb development|RNA metabolic process|G-protein coupled receptor activity|ubiquitin-like protein ligase binding|hair cycle|Wnt-activated receptor activity|ubiquitin protein ligase binding|Wnt signaling pathway|embryo development ending in birth or egg hatching|negative regulation of canonical Wnt signaling pathway|neural tube closure|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|embryonic epithelial tube formation|negative regulation of RNA biosynthetic process|epidermis development|regulation of establishment of planar polarity|ear morphogenesis|embryonic limb morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|skin epidermis development|morphogenesis of a polarized epithelium|non-canonical Wnt signaling pathway|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|chordate embryonic development|Wnt signaling pathway, planar cell polarity pathway K02376 frizzled 6[-] hsa05200|hsa05166|hsa05205|hsa04390|hsa04310|hsa04550|hsa04916|hsa05217 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human) 8:103298433-103332866 487 619 780 1315 1496 1373 3.20962159219271 3.70761859793179 4.63482831815108 7.76511991388835 8.08954627747408 8.48055083547676 3.85068950275853 8.1117390089464 -1.0748944378389 4.77688412621527e-07 6.34947011148846e-06 DOWN ENSG00000135205 CCDC146 coiled-coil domain containing 146 [Source:HGNC Symbol;Acc:HGNC:29296] GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0005737|GO:0005813|GO:0005815|GO:0005814|GO:0005856|GO:0015630 cell|binding|intracellular organelle|intracellular|protein binding|cytoplasm|centrosome|microtubule organizing center|centriole|cytoskeleton|microtubule cytoskeleton - - - - 7:77122434-77329533 21 29 45 103 107 282 0.195204233026914 0.244988460571733 0.377123813051446 0.857819107064628 0.816043596514426 2.45662381725095 0.272438835550031 1.37682884027667 -2.33734494668488 4.86024264433644e-07 6.45452330533897e-06 DOWN ENSG00000071537 SEL1L sel-1 suppressor of lin-12-like (C. elegans) [Source:HGNC Symbol;Acc:HGNC:10717] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006457|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006486|GO:0036513|GO:0006810|GO:0033554|GO:0043231|GO:0005737|GO:0005975|GO:0000835|GO:0000502|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0031647|GO:0051649|GO:0000151|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0036503|GO:0034645|GO:0007166|GO:0043412|GO:0006487|GO:0030163|GO:0050821|GO:0030970|GO:0015031|GO:0044265|GO:0009100|GO:0036211|GO:0046907|GO:0030433|GO:1990234|GO:0006508|GO:0070085|GO:0034613|GO:1901137|GO:0044267|GO:0009059|GO:0000153|GO:0034976|GO:0000836|GO:0044257|GO:0009101|GO:0043413|GO:0010498|GO:0032527|GO:0018279|GO:0006886|GO:0051603|GO:0007219|GO:0006464|GO:0019941|GO:0018193|GO:0043687|GO:0043161|GO:0006511 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|protein folding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|protein glycosylation|Derlin-1 retrotranslocation complex|transport|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|ER ubiquitin ligase complex|proteasome complex|establishment of protein localization|protein localization|cell communication|signal transduction|endoplasmic reticulum|regulation of protein stability|establishment of localization in cell|ubiquitin ligase complex|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|ERAD pathway|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|macromolecule modification|protein N-linked glycosylation|protein catabolic process|protein stabilization|retrograde protein transport, ER to cytosol|protein transport|cellular macromolecule catabolic process|glycoprotein metabolic process|protein modification process|intracellular transport|ER-associated ubiquitin-dependent protein catabolic process|transferase complex|proteolysis|glycosylation|cellular protein localization|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|cytoplasmic ubiquitin ligase complex|response to endoplasmic reticulum stress|Hrd1p ubiquitin ligase complex|cellular protein catabolic process|glycoprotein biosynthetic process|macromolecule glycosylation|proteasomal protein catabolic process|protein exit from endoplasmic reticulum|protein N-linked glycosylation via asparagine|intracellular protein transport|proteolysis involved in cellular protein catabolic process|Notch signaling pathway|cellular protein modification process|modification-dependent protein catabolic process|peptidyl-amino acid modification|post-translational protein modification|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process K14026 SEL1 protein[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 14:81471549-81533861 316 356 448 765 831 932 2.08729723286978 2.13710706323174 2.66802064269647 4.52747382853874 4.50366371086738 5.76954631941147 2.29747497959933 4.93356128627253 -1.10258028053705 4.88032719607521e-07 6.47670804630949e-06 DOWN ENSG00000136881 BAAT bile acid-CoA:amino acid N-acyltransferase [Source:HGNC Symbol;Acc:HGNC:932] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0044255|GO:0006810|GO:1901360|GO:0006082|GO:0007275|GO:0048513|GO:0005102|GO:0016788|GO:0044281|GO:0043231|GO:0016746|GO:0005737|GO:0006520|GO:0051186|GO:0006629|GO:0044249|GO:0010876|GO:0048732|GO:0006790|GO:0019530|GO:0005829|GO:0006637|GO:0006631|GO:0031100|GO:0001889|GO:0016790|GO:0006811|GO:0006869|GO:0016747|GO:0008202|GO:0008610|GO:0008206|GO:0052689|GO:0006820|GO:0015711|GO:0006699|GO:0005777|GO:0015721|GO:0002152|GO:0005782|GO:0046942|GO:0006694|GO:0016410|GO:0019752|GO:0009069|GO:0047963|GO:0015718|GO:0006544|GO:0047617|GO:0032787|GO:0016290|GO:0052815|GO:0052816|GO:0052817 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|transferase activity|anatomical structure development|cellular lipid metabolic process|transport|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|animal organ development|receptor binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|cellular amino acid metabolic process|cofactor metabolic process|lipid metabolic process|cellular biosynthetic process|lipid localization|gland development|sulfur compound metabolic process|taurine metabolic process|cytosol|acyl-CoA metabolic process|fatty acid metabolic process|organ regeneration|liver development|thiolester hydrolase activity|ion transport|lipid transport|transferase activity, transferring acyl groups other than amino-acyl groups|steroid metabolic process|lipid biosynthetic process|bile acid metabolic process|carboxylic ester hydrolase activity|anion transport|organic anion transport|bile acid biosynthetic process|peroxisome|bile acid and bile salt transport|bile acid conjugation|peroxisomal matrix|carboxylic acid transport|steroid biosynthetic process|N-acyltransferase activity|carboxylic acid metabolic process|serine family amino acid metabolic process|glycine N-choloyltransferase activity|monocarboxylic acid transport|glycine metabolic process|acyl-CoA hydrolase activity|monocarboxylic acid metabolic process|palmitoyl-CoA hydrolase activity|medium-chain acyl-CoA hydrolase activity|long-chain acyl-CoA hydrolase activity|very long chain acyl-CoA hydrolase activity - - - - 9:101360417-101383519 7 13 11 0 0 1 0.0912583986567645 0.154029736764794 0.129289568335234 0 0 0.0122163187205525 0.124859234585598 0.00407210624018417 4.93838351523291 4.88128662966314e-07 6.47670804630949e-06 UP ENSG00000044459 CNTLN centlein [Source:HGNC Symbol;Acc:HGNC:23432] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0060090|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0005057|GO:0071704|GO:0044237|GO:0051641|GO:0038023|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0016772|GO:0031982|GO:0019899|GO:0005737|GO:0030674|GO:0019904|GO:0008104|GO:0007154|GO:0007165|GO:0000155|GO:0070062|GO:0007017|GO:0019538|GO:0023014|GO:0006996|GO:0031023|GO:0005813|GO:0043412|GO:0007010|GO:0005815|GO:0005814|GO:0036211|GO:0016301|GO:0034613|GO:0019900|GO:0006796|GO:0035556|GO:0044267|GO:0000226|GO:0016773|GO:0005856|GO:0033365|GO:0016310|GO:0015630|GO:0000160|GO:0051297|GO:0004672|GO:0004673|GO:0019901|GO:0006464|GO:0006468|GO:0010457 signal transducer activity|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|binding, bridging|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|receptor signaling protein activity|organic substance metabolic process|cellular metabolic process|cellular localization|signaling receptor activity|cellular component organization|membrane-bounded organelle|intracellular|protein binding|transferase activity|transferase activity, transferring phosphorus-containing groups|vesicle|enzyme binding|cytoplasm|protein binding, bridging|protein domain specific binding|protein localization|cell communication|signal transduction|phosphorelay sensor kinase activity|extracellular exosome|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|organelle organization|microtubule organizing center organization|centrosome|macromolecule modification|cytoskeleton organization|microtubule organizing center|centriole|protein modification process|kinase activity|cellular protein localization|kinase binding|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|protein localization to organelle|phosphorylation|microtubule cytoskeleton|phosphorelay signal transduction system|centrosome organization|protein kinase activity|protein histidine kinase activity|protein kinase binding|cellular protein modification process|protein phosphorylation|centriole-centriole cohesion - - - - 9:17134982-17503923 39 41 41 111 130 125 0.232782747987662 0.222412438604313 0.220639609259526 0.593625029585393 0.636652163566413 0.699246976919314 0.225278265283834 0.64317472335704 -1.51350258008525 4.88797323623055e-07 6.48269893355962e-06 DOWN ENSG00000272869 CTC-487M23.8 - GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0051641|GO:0016043|GO:0005622|GO:0006810|GO:0003676|GO:0005737|GO:0030529|GO:0045184|GO:0008104|GO:0061024|GO:0051649|GO:0090150|GO:0003723|GO:0072594|GO:0045047|GO:0015031|GO:0046907|GO:0072657|GO:0034613|GO:0048500|GO:0008312|GO:0006614|GO:0033365|GO:0006605|GO:0006886|GO:0006612|GO:0072599|GO:0070972|GO:0006613 macromolecular complex|cell|cellular process|binding|organic cyclic compound binding|cellular localization|cellular component organization|intracellular|transport|nucleic acid binding|cytoplasm|intracellular ribonucleoprotein complex|establishment of protein localization|protein localization|membrane organization|establishment of localization in cell|establishment of protein localization to membrane|RNA binding|establishment of protein localization to organelle|protein targeting to ER|protein transport|intracellular transport|protein localization to membrane|cellular protein localization|signal recognition particle|7S RNA binding|SRP-dependent cotranslational protein targeting to membrane|protein localization to organelle|protein targeting|intracellular protein transport|protein targeting to membrane|establishment of protein localization to endoplasmic reticulum|protein localization to endoplasmic reticulum|cotranslational protein targeting to membrane - - - - 5:112861188-112893079 103 63 3 1 2 2 1.79235459259039 0.99634205550781 0.0470604629306941 0.0155839590407902 0.0285530956506203 0.0326129128549658 0.945252370342965 0.0255833225154588 5.20742401712934 4.89956461795624e-07 6.49518659433683e-06 UP ENSG00000123472 ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:18803] GO:0005623|GO:0009987|GO:0005488|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0022607|GO:0043231|GO:0005737|GO:0006996|GO:0007005|GO:0005739|GO:0006461|GO:0043461|GO:0034622|GO:0043623|GO:0033615 cell|cellular process|binding|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|organelle organization|mitochondrion organization|mitochondrion|protein complex assembly|proton-transporting ATP synthase complex assembly|cellular macromolecular complex assembly|cellular protein complex assembly|mitochondrial proton-transporting ATP synthase complex assembly - - - - 1:46632737-46673867 545 671 701 1378 1445 1347 3.23446715184534 3.61916353047349 3.75092259027651 7.32744906908836 7.03625759367429 7.49208081106638 3.53485109086511 7.28526249127634 -1.04333151283156 4.90332895224099e-07 6.49729172393265e-06 DOWN ENSG00000204859 ZBTB48 zinc finger and BTB domain containing 48 [Source:HGNC Symbol;Acc:HGNC:4930] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 1:6580001-6589280 283 319 311 167 134 123 2.14745323944322 2.19992274060084 2.12770580973234 1.13540546397502 0.834273917406683 0.874726929061934 2.15836059659213 0.948135436814546 1.18677085419611 4.90890898306595e-07 6.50179985716286e-06 UP ENSG00000132694 ARHGEF11 Rho guanine nucleotide exchange factor 11 [Source:HGNC Symbol;Acc:HGNC:14580] GO:0040011|GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0005085|GO:0048856|GO:0019222|GO:0007049|GO:0006935|GO:0006725|GO:0048468|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0005102|GO:0034641|GO:0008047|GO:0031325|GO:0046483|GO:0051128|GO:0010942|GO:0005737|GO:0003012|GO:0005088|GO:0006928|GO:0009966|GO:0010646|GO:0006139|GO:0043085|GO:0007163|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0030030|GO:0051301|GO:0048869|GO:0030029|GO:0044249|GO:0010033|GO:0001558|GO:0031323|GO:0006996|GO:0000902|GO:0005829|GO:0031175|GO:0007186|GO:0010468|GO:0006936|GO:0034645|GO:0005096|GO:0007166|GO:0007010|GO:0051345|GO:0030695|GO:0051252|GO:0000904|GO:0010628|GO:0030010|GO:0070848|GO:0001664|GO:0030036|GO:0012501|GO:0035556|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0031328|GO:0009059|GO:0030154|GO:0048858|GO:0005089|GO:0043068|GO:1902531|GO:0016070|GO:0000910|GO:0010557|GO:0043067|GO:0097190|GO:0048666|GO:0006941|GO:0030182|GO:0007411|GO:0045893|GO:0043065|GO:0032774|GO:2001141|GO:0071363|GO:0043087|GO:0038179|GO:0061564|GO:0043547|GO:0007167|GO:0042981|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0048812|GO:0006351|GO:0006915|GO:0006355|GO:0048011|GO:0007265|GO:0046578|GO:0007409|GO:0048699|GO:1903506|GO:0007169|GO:0035023|GO:0007266 locomotion|developmental process|growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|intracellular|protein binding|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|cell cycle|chemotaxis|cellular aromatic compound metabolic process|cell development|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|receptor binding|cellular nitrogen compound metabolic process|enzyme activator activity|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell death|cytoplasm|muscle system process|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|establishment or maintenance of cell polarity|cell communication|signal transduction|cell death|regulation of catalytic activity|cell projection organization|cell division|cellular developmental process|actin filament-based process|cellular biosynthetic process|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|organelle organization|cell morphogenesis|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|GTPase activator activity|cell surface receptor signaling pathway|cytoskeleton organization|positive regulation of hydrolase activity|GTPase regulator activity|regulation of RNA metabolic process|cell morphogenesis involved in differentiation|positive regulation of gene expression|establishment of cell polarity|response to growth factor|G-protein coupled receptor binding|actin cytoskeleton organization|programmed cell death|intracellular signal transduction|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|cytokinesis|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|apoptotic signaling pathway|neuron development|striated muscle contraction|neuron differentiation|axon guidance|positive regulation of transcription, DNA-templated|positive regulation of apoptotic process|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|regulation of GTPase activity|neurotrophin signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of apoptotic process|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|neuron projection morphogenesis|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction K12331 Rho guanine nucleotide exchange factor 11[-] hsa05200|hsa04270 Pathways in cancer - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human) 1:156934840-157045370 349 431 526 929 1051 888 1.87194214706668 2.10099011379563 2.54370546115201 4.46457813666076 4.6252747361304 4.46384183759523 2.17221257400477 4.51789823679546 -1.05648648213537 4.91961414754336e-07 6.51308916899155e-06 DOWN ENSG00000111728 ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10869] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0008284|GO:0042127|GO:0044255|GO:0031228|GO:0033554|GO:0043231|GO:0005737|GO:0009408|GO:0005975|GO:0006629|GO:0016757|GO:0016021|GO:0044249|GO:0009266|GO:0019538|GO:0031301|GO:0005794|GO:0006490|GO:0034645|GO:0006665|GO:0043412|GO:0006487|GO:0006643|GO:0030173|GO:0009100|GO:0036211|GO:0008373|GO:0034605|GO:0070085|GO:1901137|GO:0044267|GO:0008610|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0006687|GO:0006488|GO:0009247|GO:0018279|GO:0097503|GO:0006664|GO:0003828|GO:0030148|GO:0006464|GO:0006688|GO:0018193|GO:0043687 cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|positive regulation of cell proliferation|regulation of cell proliferation|cellular lipid metabolic process|intrinsic component of Golgi membrane|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|response to heat|carbohydrate metabolic process|lipid metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|integral component of organelle membrane|Golgi apparatus|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|sphingolipid metabolic process|macromolecule modification|protein N-linked glycosylation|membrane lipid metabolic process|integral component of Golgi membrane|glycoprotein metabolic process|protein modification process|sialyltransferase activity|cellular response to heat|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|lipid biosynthetic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|glycosphingolipid metabolic process|dolichol-linked oligosaccharide biosynthetic process|glycolipid biosynthetic process|protein N-linked glycosylation via asparagine|sialylation|glycolipid metabolic process|alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity|sphingolipid biosynthetic process|cellular protein modification process|glycosphingolipid biosynthetic process|peptidyl-amino acid modification|post-translational protein modification K03371 alpha-N-acetyl-neuraminate alpha-2,8-sialyltransferase (sialyltransferase 8A)[2.4.99.8] hsa01100|hsa00601|hsa00604|hsa00603 Metabolic pathways - Homo sapiens (human)|Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human)|Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human)|Glycosphingolipid biosynthesis - globo series - Homo sapiens (human) 12:22063773-22437041 5 6 8 30 48 27 0.0173255422588917 0.0188941372752592 0.0249926238537207 0.0931355111434238 0.1364591905815 0.0876770352902079 0.0204041011292905 0.105757245671711 -2.37382544764221 4.99085157583311e-07 6.60447176174298e-06 DOWN ENSG00000204519 ZNF551 zinc finger protein 551 [Source:HGNC Symbol;Acc:HGNC:25108] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 19:57681969-57717301 684 1126 973 515 499 315 6.71627011782446 10.0482542809083 8.61388246226203 4.53081857631997 4.02013526854126 2.89875331950945 8.45946895366493 3.81656905479023 1.14829080561156 5.00926738224477e-07 6.62590467122443e-06 UP ENSG00000204152 TIMM23B translocase of inner mitochondrial membrane 23 homolog B (yeast) [Source:HGNC Symbol;Acc:HGNC:23581] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0043234|GO:0031090|GO:0019866|GO:0008565|GO:0006810|GO:0043231|GO:0005737|GO:0031966|GO:0045184|GO:0022891|GO:0008104|GO:0055085|GO:0051649|GO:0016021|GO:0031301|GO:0006996|GO:0005740|GO:0072594|GO:0007005|GO:0015031|GO:0015267|GO:0046907|GO:0008320|GO:0005743|GO:0031304|GO:0005739|GO:0034613|GO:0032592|GO:0017038|GO:0006626|GO:0030150|GO:0005744|GO:0071806|GO:0033365|GO:0006839|GO:0006605|GO:0072655|GO:0031305|GO:0006886|GO:0065002|GO:0015266|GO:0015450|GO:0070585 macromolecular complex|transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein complex|organelle membrane|organelle inner membrane|protein transporter activity|transport|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|establishment of protein localization|substrate-specific transmembrane transporter activity|protein localization|transmembrane transport|establishment of localization in cell|integral component of membrane|integral component of organelle membrane|organelle organization|mitochondrial envelope|establishment of protein localization to organelle|mitochondrion organization|protein transport|channel activity|intracellular transport|protein transmembrane transporter activity|mitochondrial inner membrane|intrinsic component of mitochondrial inner membrane|mitochondrion|cellular protein localization|integral component of mitochondrial membrane|protein import|protein targeting to mitochondrion|protein import into mitochondrial matrix|mitochondrial inner membrane presequence translocase complex|protein transmembrane transport|protein localization to organelle|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|integral component of mitochondrial inner membrane|intracellular protein transport|intracellular protein transmembrane transport|protein channel activity|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein localization to mitochondrion - - - - 10:49942033-49974850 28 41 50 134 130 106 0.409893630690712 0.545490440790505 0.659941194429209 1.75761129479877 1.5614579450384 1.45430582114928 0.538441755303475 1.59112502032882 -1.56318499967264 5.05831901666148e-07 6.68782355728131e-06 DOWN ENSG00000154217 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 [Source:HGNC Symbol;Acc:HGNC:21045] GO:0005215|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0006810|GO:0043231|GO:0005737|GO:0005319|GO:0007154|GO:0007165|GO:0010876|GO:0005548|GO:0006811|GO:0031981|GO:0006869|GO:0005654|GO:0005634|GO:0015914|GO:0006820|GO:0015711|GO:0008526 transporter activity|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|membrane-bounded organelle|lipid binding|intracellular|protein binding|transport|intracellular membrane-bounded organelle|cytoplasm|lipid transporter activity|cell communication|signal transduction|lipid localization|phospholipid transporter activity|ion transport|nuclear lumen|lipid transport|nucleoplasm|nucleus|phospholipid transport|anion transport|organic anion transport|phosphatidylinositol transporter activity - - - - 17:67377281-67697261 19 30 28 87 77 99 0.0903995982033756 0.129724830992943 0.120112915016765 0.37088678827366 0.300595313074618 0.441456581246984 0.113412448071028 0.370979560865087 -1.70976070551989 5.09331160822963e-07 6.73110778008356e-06 DOWN ENSG00000173530 TNFRSF10D tumor necrosis factor receptor superfamily member 10d [Source:HGNC Symbol;Acc:HGNC:11907] GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0006955|GO:0038023|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0042127|GO:0010941|GO:0007275|GO:0006952|GO:0005887|GO:0004888|GO:0045569|GO:0060548|GO:0031226|GO:0009617|GO:0007154|GO:0007165|GO:0008219|GO:0016021|GO:0010033|GO:0007166|GO:0033993|GO:0034097|GO:0002237|GO:0043069|GO:0005035|GO:0006954|GO:0012501|GO:0071310|GO:0032496|GO:0043067|GO:0097190|GO:0019221|GO:0005031|GO:0042981|GO:0071345|GO:0043066|GO:0034612|GO:0097191|GO:0006915|GO:0071356|GO:0033209|GO:0008625 developmental process|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|immune response|signaling receptor activity|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|regulation of cell proliferation|regulation of cell death|multicellular organism development|defense response|integral component of plasma membrane|transmembrane signaling receptor activity|TRAIL binding|negative regulation of cell death|intrinsic component of plasma membrane|response to bacterium|cell communication|signal transduction|cell death|integral component of membrane|response to organic substance|cell surface receptor signaling pathway|response to lipid|response to cytokine|response to molecule of bacterial origin|negative regulation of programmed cell death|death receptor activity|inflammatory response|programmed cell death|cellular response to organic substance|response to lipopolysaccharide|regulation of programmed cell death|apoptotic signaling pathway|cytokine-mediated signaling pathway|tumor necrosis factor-activated receptor activity|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|response to tumor necrosis factor|extrinsic apoptotic signaling pathway|apoptotic process|cellular response to tumor necrosis factor|tumor necrosis factor-mediated signaling pathway|extrinsic apoptotic signaling pathway via death domain receptors K04722 tumor necrosis factor receptor superfamily member 10[-] hsa04060|hsa05164|hsa04210|hsa05162|hsa04650 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Measles - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human) 8:23135588-23164030 1328 1316 955 563 607 632 26.5513128371369 23.9124395801828 17.2149437734733 10.0854250510811 9.95736329855326 11.8422498120401 22.559565396931 10.6283460538915 1.08582216775943 5.14194889309312e-07 6.79021328992024e-06 UP ENSG00000228044 RP4-781K5.4 - - - - - - - 1:234646289-234683176 24 25 23 85 77 83 0.700070833692725 0.662768237787467 0.604891472885584 2.22153079424777 1.84286619360014 2.26904001396067 0.655910181455259 2.11114566726953 -1.68645595208815 5.14258466152263e-07 6.79021328992024e-06 DOWN ENSG00000085733 CTTN cortactin [Source:HGNC Symbol;Acc:HGNC:3338] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0030055|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0016049|GO:0044089|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0030427|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0023057|GO:0031252|GO:0031224|GO:0005905|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0019222|GO:0010506|GO:0045595|GO:0048468|GO:0006810|GO:0051130|GO:0005884|GO:0010941|GO:0005938|GO:0009991|GO:0098797|GO:0007275|GO:0032535|GO:0005924|GO:0005912|GO:0031982|GO:0051128|GO:0030426|GO:0033554|GO:0022607|GO:0005887|GO:0043231|GO:0005737|GO:0032970|GO:0003012|GO:0001726|GO:0006928|GO:0043005|GO:0031589|GO:0009966|GO:0030027|GO:0045184|GO:0043197|GO:0036477|GO:0060548|GO:0010646|GO:0031226|GO:0008104|GO:1902495|GO:0007154|GO:0016477|GO:0007165|GO:0048588|GO:0000422|GO:0009968|GO:0070062|GO:0048638|GO:0051649|GO:0005522|GO:0008219|GO:0016236|GO:0030030|GO:0048869|GO:0016021|GO:0030029|GO:0043954|GO:0031334|GO:0043254|GO:0001558|GO:0031323|GO:0005794|GO:0006996|GO:0002102|GO:0060560|GO:0016192|GO:0000902|GO:0031175|GO:0031344|GO:0006936|GO:0045216|GO:1903008|GO:0007166|GO:0032956|GO:0007010|GO:0044309|GO:0007005|GO:0043069|GO:0097061|GO:2001234|GO:0015031|GO:1903146|GO:0000904|GO:0090257|GO:0051233|GO:0007160|GO:0046907|GO:0016241|GO:0034329|GO:0008076|GO:0030031|GO:0030425|GO:0097062|GO:0008361|GO:0022604|GO:0034702|GO:0006461|GO:0030036|GO:0034613|GO:0045987|GO:0012501|GO:0097581|GO:0035556|GO:0032273|GO:0006929|GO:0033043|GO:0030516|GO:0032990|GO:0007399|GO:0030154|GO:0030832|GO:0048858|GO:0031667|GO:0005856|GO:0005819|GO:0043067|GO:1990138|GO:0051960|GO:0005925|GO:0097190|GO:0010638|GO:0048666|GO:0030182|GO:2001237|GO:0015629|GO:0010975|GO:0006930|GO:0072686|GO:0031532|GO:0006939|GO:0034622|GO:0006937|GO:0030838|GO:0010769|GO:0034332|GO:0034703|GO:0043623|GO:2001236|GO:1990023|GO:0008064|GO:0061564|GO:0006886|GO:0051493|GO:0007044|GO:0015630|GO:0010821|GO:0042981|GO:0048041|GO:0043066|GO:0006897|GO:0022008|GO:0048667|GO:0007264|GO:0030863|GO:0007015|GO:0050767|GO:0051495|GO:0048812|GO:0097191|GO:0030833|GO:0006915|GO:0048675|GO:0034333|GO:0051258|GO:0006940|GO:0007409|GO:0048699|GO:0034705|GO:0006898|GO:0050770|GO:0045664|GO:0008154|GO:0030041 locomotion|developmental process|growth|macromolecular complex|synapse|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|cell growth|positive regulation of cellular component biogenesis|catabolic process|cellular metabolic process|cellular localization|autophagy|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|negative regulation of signaling|cell leading edge|intrinsic component of membrane|coated pit|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of autophagy|regulation of cell differentiation|cell development|transport|positive regulation of cellular component organization|actin filament|regulation of cell death|cell cortex|response to extracellular stimulus|plasma membrane protein complex|multicellular organism development|regulation of cellular component size|cell-substrate adherens junction|adherens junction|vesicle|regulation of cellular component organization|growth cone|cellular response to stress|cellular component assembly|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|regulation of actin filament-based process|muscle system process|ruffle|movement of cell or subcellular component|neuron projection|cell-substrate adhesion|regulation of signal transduction|lamellipodium|establishment of protein localization|dendritic spine|somatodendritic compartment|negative regulation of cell death|regulation of cell communication|intrinsic component of plasma membrane|protein localization|transmembrane transporter complex|cell communication|cell migration|signal transduction|developmental cell growth|mitophagy|negative regulation of signal transduction|extracellular exosome|regulation of developmental growth|establishment of localization in cell|profilin binding|cell death|macroautophagy|cell projection organization|cellular developmental process|integral component of membrane|actin filament-based process|cellular component maintenance|positive regulation of protein complex assembly|regulation of protein complex assembly|regulation of cell growth|regulation of cellular metabolic process|Golgi apparatus|organelle organization|podosome|developmental growth involved in morphogenesis|vesicle-mediated transport|cell morphogenesis|neuron projection development|regulation of cell projection organization|muscle contraction|cell-cell junction organization|organelle disassembly|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|cytoskeleton organization|neuron spine|mitochondrion organization|negative regulation of programmed cell death|dendritic spine organization|negative regulation of apoptotic signaling pathway|protein transport|regulation of mitophagy|cell morphogenesis involved in differentiation|regulation of muscle system process|spindle midzone|cell-matrix adhesion|intracellular transport|regulation of macroautophagy|cell junction assembly|voltage-gated potassium channel complex|cell projection assembly|dendrite|dendritic spine maintenance|regulation of cell size|regulation of cell morphogenesis|ion channel complex|protein complex assembly|actin cytoskeleton organization|cellular protein localization|positive regulation of smooth muscle contraction|programmed cell death|lamellipodium organization|intracellular signal transduction|positive regulation of protein polymerization|substrate-dependent cell migration|regulation of organelle organization|regulation of axon extension|cell part morphogenesis|nervous system development|cell differentiation|regulation of actin filament length|cell projection morphogenesis|response to nutrient levels|cytoskeleton|spindle|regulation of programmed cell death|neuron projection extension|regulation of nervous system development|focal adhesion|apoptotic signaling pathway|positive regulation of organelle organization|neuron development|neuron differentiation|negative regulation of extrinsic apoptotic signaling pathway|actin cytoskeleton|regulation of neuron projection development|substrate-dependent cell migration, cell extension|mitotic spindle|actin cytoskeleton reorganization|smooth muscle contraction|cellular macromolecular complex assembly|regulation of muscle contraction|positive regulation of actin filament polymerization|regulation of cell morphogenesis involved in differentiation|adherens junction organization|cation channel complex|cellular protein complex assembly|regulation of extrinsic apoptotic signaling pathway|mitotic spindle midzone|regulation of actin polymerization or depolymerization|axon development|intracellular protein transport|regulation of cytoskeleton organization|cell-substrate junction assembly|microtubule cytoskeleton|regulation of mitochondrion organization|regulation of apoptotic process|focal adhesion assembly|negative regulation of apoptotic process|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cortical cytoskeleton|actin filament organization|regulation of neurogenesis|positive regulation of cytoskeleton organization|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|regulation of actin filament polymerization|apoptotic process|axon extension|adherens junction assembly|protein polymerization|regulation of smooth muscle contraction|axonogenesis|generation of neurons|potassium channel complex|receptor-mediated endocytosis|regulation of axonogenesis|regulation of neuron differentiation|actin polymerization or depolymerization|actin filament polymerization K06106 cortactin[-] hsa05205|hsa04530|hsa05100|hsa05131|hsa05130 Proteoglycans in cancer - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human) 11:70398404-70436584 3349 3938 4649 8187 9350 8204 18.6621817206079 19.9435717531081 23.3572124072683 40.87612794071 42.7490854542418 42.8451642739238 20.6543219603281 42.1567925562919 -1.02932140540265 5.17473097196796e-07 6.8296383040288e-06 DOWN ENSG00000100749 VRK1 vaccinia related kinase 1 [Source:HGNC Symbol;Acc:HGNC:12718] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0044877|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0007049|GO:0042393|GO:0022402|GO:0016570|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0019899|GO:0005737|GO:0032403|GO:0003682|GO:0061024|GO:0000166|GO:0051301|GO:0016021|GO:0019538|GO:0010256|GO:0005794|GO:0006996|GO:0051276|GO:0005730|GO:0005829|GO:0006998|GO:1903008|GO:0035639|GO:1903047|GO:0043412|GO:0007030|GO:0016572|GO:0006325|GO:0001883|GO:0036211|GO:0000278|GO:0032549|GO:0031981|GO:0005654|GO:0031491|GO:0016301|GO:0019900|GO:0006796|GO:0005795|GO:0044267|GO:0007067|GO:0017076|GO:0006997|GO:0016773|GO:0031493|GO:0005856|GO:0005634|GO:0005819|GO:0007077|GO:0007084|GO:0035404|GO:0005524|GO:0030554|GO:0016310|GO:0031468|GO:0015630|GO:0051081|GO:0004672|GO:0016568|GO:0019901|GO:0006464|GO:0090166|GO:0043987|GO:0072355|GO:0035173|GO:0006468|GO:0018193|GO:0004674|GO:0035174|GO:0046777|GO:0018105|GO:0018107|GO:0072354|GO:0035175 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|cell cycle|histone binding|cell cycle process|histone modification|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein complex binding|chromatin binding|membrane organization|nucleotide binding|cell division|integral component of membrane|protein metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|chromosome organization|nucleolus|cytosol|nuclear envelope organization|organelle disassembly|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|Golgi organization|histone phosphorylation|chromatin organization|purine nucleoside binding|protein modification process|mitotic cell cycle|ribonucleoside binding|nuclear lumen|nucleoplasm|nucleosome binding|kinase activity|kinase binding|phosphate-containing compound metabolic process|Golgi stack|cellular protein metabolic process|mitotic nuclear division|purine nucleotide binding|nucleus organization|phosphotransferase activity, alcohol group as acceptor|nucleosomal histone binding|cytoskeleton|nucleus|spindle|mitotic nuclear envelope disassembly|mitotic nuclear envelope reassembly|histone-serine phosphorylation|ATP binding|adenyl nucleotide binding|phosphorylation|nuclear envelope reassembly|microtubule cytoskeleton|nuclear envelope disassembly|protein kinase activity|chromatin modification|protein kinase binding|cellular protein modification process|Golgi disassembly|histone H3-S10 phosphorylation|histone H3-T3 phosphorylation|histone kinase activity|protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|histone serine kinase activity|protein autophosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|histone kinase activity (H3-T3 specific)|histone kinase activity (H3-S10 specific) - - - - 14:96797304-96931722 65 83 96 293 285 171 1.18137551514694 1.37098573926532 1.5731139504052 4.77132083524875 4.24996683854616 2.91271140662842 1.37515840160582 3.97799969347444 -1.53244535578611 5.22497138650434e-07 6.88985405356451e-06 DOWN ENSG00000121350 PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 [Source:HGNC Symbol;Acc:HGNC:26162] GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0005515|GO:0055114 metabolic process|binding|catalytic activity|oxidoreductase activity|protein binding|oxidation-reduction process - - - - 12:21437615-21471252 143 184 200 393 469 422 1.03186743432667 1.20665751122603 1.3011605281622 2.54083540534769 2.77669215796968 2.85383151962839 1.17989515790497 2.72378636098192 -1.2069548790747 5.26296153836505e-07 6.9368853759978e-06 DOWN ENSG00000107968 MAP3K8 mitogen-activated protein kinase kinase kinase 8 [Source:HGNC Symbol;Acc:HGNC:6860] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0045321|GO:0006950|GO:0005057|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0007155|GO:0009893|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0019222|GO:0002757|GO:0051726|GO:0007049|GO:0016337|GO:0045087|GO:0050867|GO:0010941|GO:0070489|GO:0043168|GO:0006952|GO:0030155|GO:0001882|GO:0016772|GO:0031325|GO:0033554|GO:0098609|GO:0043169|GO:0005737|GO:0002218|GO:0002696|GO:0001775|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0050778|GO:0045785|GO:0004702|GO:0008219|GO:0050790|GO:0031295|GO:0000166|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:1902533|GO:0051249|GO:0032268|GO:0005829|GO:0046872|GO:0035639|GO:0043412|GO:0002758|GO:0001883|GO:0034109|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0051251|GO:0022407|GO:0031098|GO:0007346|GO:0007159|GO:0051247|GO:0002764|GO:0016301|GO:0032270|GO:0042110|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:0022409|GO:1902531|GO:0004709|GO:0016773|GO:0043067|GO:0045089|GO:0045088|GO:0031401|GO:0050863|GO:0043408|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0034112|GO:0002221|GO:0070486|GO:0043410|GO:0042981|GO:0004672|GO:0006464|GO:0050870|GO:0051403|GO:0043549|GO:0006915|GO:1903039|GO:0033674|GO:0000186|GO:0045859|GO:0045860|GO:0002224|GO:0006468|GO:0043405|GO:0042325|GO:0001932|GO:0004674|GO:0001934|GO:0071593|GO:0042327|GO:0034166|GO:0034134|GO:0038124|GO:0002756|GO:0034138|GO:0002755|GO:0034146|GO:0071900|GO:0034142|GO:0038123|GO:0034162|GO:0032147|GO:0035666 signal transducer activity|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|leukocyte activation|response to stress|receptor signaling protein activity|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cell adhesion|positive regulation of metabolic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|transferase activity|regulation of metabolic process|immune response-activating signal transduction|regulation of cell cycle|cell cycle|single organismal cell-cell adhesion|innate immune response|positive regulation of cell activation|regulation of cell death|T cell aggregation|anion binding|defense response|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|cellular response to stress|cell-cell adhesion|cation binding|cytoplasm|activation of innate immune response|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|positive regulation of immune response|positive regulation of cell adhesion|receptor signaling protein serine/threonine kinase activity|cell death|regulation of catalytic activity|T cell costimulation|nucleotide binding|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|purine nucleoside binding|homotypic cell-cell adhesion|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|immune response-regulating signaling pathway|kinase activity|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|positive regulation of cell-cell adhesion|regulation of intracellular signal transduction|MAP kinase kinase kinase activity|phosphotransferase activity, alcohol group as acceptor|regulation of programmed cell death|positive regulation of innate immune response|regulation of innate immune response|positive regulation of protein modification process|regulation of T cell activation|regulation of MAPK cascade|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|positive regulation of homotypic cell-cell adhesion|pattern recognition receptor signaling pathway|leukocyte aggregation|positive regulation of MAPK cascade|regulation of apoptotic process|protein kinase activity|cellular protein modification process|positive regulation of T cell activation|stress-activated MAPK cascade|regulation of kinase activity|apoptotic process|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|activation of MAPKK activity|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|lymphocyte aggregation|positive regulation of phosphorylation|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|regulation of protein serine/threonine kinase activity|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|activation of protein kinase activity|TRIF-dependent toll-like receptor signaling pathway K04415 mitogen-activated protein kinase kinase kinase 8[2.7.11.25] hsa04010|hsa04668|hsa04620|hsa04660 MAPK signaling pathway - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human) 10:30433937-30461833 357 372 580 189 206 227 3.62674731281066 3.43457377893574 5.31241356902793 1.72031658398872 1.71705472961677 2.16124776001764 4.12457822025811 1.86620635787438 1.14413807413299 5.26597315891115e-07 6.93779182198294e-06 UP ENSG00000167740 CYB5D2 cytochrome b5 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28471] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0097159|GO:0050794|GO:0050793|GO:0012505|GO:0048856|GO:0045595|GO:0048468|GO:0007275|GO:0045597|GO:0048869|GO:0020037|GO:0010720|GO:0050769|GO:0007399|GO:0030154|GO:0051960|GO:0030182|GO:0022008|GO:0050767|GO:0045666|GO:0048699|GO:0045664 developmental process|cell|membrane|cellular process|extracellular region|binding|organic cyclic compound binding|regulation of cellular process|regulation of developmental process|endomembrane system|anatomical structure development|regulation of cell differentiation|cell development|multicellular organism development|positive regulation of cell differentiation|cellular developmental process|heme binding|positive regulation of cell development|positive regulation of neurogenesis|nervous system development|cell differentiation|regulation of nervous system development|neuron differentiation|neurogenesis|regulation of neurogenesis|positive regulation of neuron differentiation|generation of neurons|regulation of neuron differentiation - - - - 17:4143168-4187310 73 92 78 218 240 209 1.18110292967456 1.35279775646715 1.1378212623596 3.16024177511566 3.18599911283268 3.16914082861462 1.2239073161671 3.17179390552099 -1.37380472169901 5.32777533572159e-07 7.01302490620073e-06 DOWN ENSG00000092871 RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:24821] GO:0040011|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0043227|GO:0071944|GO:0023057|GO:0016874|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0010941|GO:0002039|GO:0097194|GO:0060761|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0043235|GO:0006928|GO:0009966|GO:0060548|GO:0010646|GO:0007154|GO:0044092|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0008219|GO:0019787|GO:0010008|GO:0050790|GO:0043086|GO:2000145|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0005768|GO:0002947|GO:0032268|GO:0005829|GO:0046872|GO:0007166|GO:0001959|GO:0043412|GO:0034097|GO:0030163|GO:0004842|GO:0043069|GO:2001234|GO:0044265|GO:0030334|GO:0001667|GO:0036211|GO:0032269|GO:1900117|GO:0002020|GO:0055037|GO:0051346|GO:0006508|GO:0019900|GO:0012501|GO:0035556|GO:0044267|GO:1900118|GO:0071310|GO:1902532|GO:0051246|GO:0001960|GO:1902531|GO:0043067|GO:0097190|GO:0044389|GO:0055038|GO:2001237|GO:0031625|GO:0044257|GO:0032006|GO:0010466|GO:0019221|GO:0061630|GO:1901797|GO:0010498|GO:0010803|GO:0031929|GO:0072331|GO:0030162|GO:2001236|GO:0052547|GO:0010804|GO:0051603|GO:0010762|GO:1901796|GO:0042981|GO:0071345|GO:0045861|GO:0046914|GO:0043066|GO:0034612|GO:2001271|GO:0019901|GO:0006464|GO:0097191|GO:0010761|GO:0006915|GO:0043281|GO:0019941|GO:0071356|GO:0010951|GO:0033209|GO:1902042|GO:0043154|GO:0008270|GO:0008625|GO:0043161|GO:1902041|GO:0052548|GO:0032446|GO:0006511|GO:2000117|GO:2000116|GO:0042787|GO:0016567|GO:0000209|GO:0070936 locomotion|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|membrane-bounded organelle|cell periphery|negative regulation of signaling|ligase activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|regulation of cell death|p53 binding|execution phase of apoptosis|negative regulation of response to cytokine stimulus|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|receptor complex|movement of cell or subcellular component|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|cell communication|negative regulation of molecular function|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|cell death|ubiquitin-like protein transferase activity|endosome membrane|regulation of catalytic activity|negative regulation of catalytic activity|regulation of cell motility|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endosome|tumor necrosis factor receptor superfamily complex|regulation of cellular protein metabolic process|cytosol|metal ion binding|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|macromolecule modification|response to cytokine|protein catabolic process|ubiquitin-protein transferase activity|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|cellular macromolecule catabolic process|regulation of cell migration|ameboidal-type cell migration|protein modification process|negative regulation of cellular protein metabolic process|regulation of execution phase of apoptosis|protease binding|recycling endosome|negative regulation of hydrolase activity|proteolysis|kinase binding|programmed cell death|intracellular signal transduction|cellular protein metabolic process|negative regulation of execution phase of apoptosis|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|negative regulation of cytokine-mediated signaling pathway|regulation of intracellular signal transduction|regulation of programmed cell death|apoptotic signaling pathway|ubiquitin-like protein ligase binding|recycling endosome membrane|negative regulation of extrinsic apoptotic signaling pathway|ubiquitin protein ligase binding|cellular protein catabolic process|regulation of TOR signaling|negative regulation of peptidase activity|cytokine-mediated signaling pathway|ubiquitin protein ligase activity|negative regulation of signal transduction by p53 class mediator|proteasomal protein catabolic process|regulation of tumor necrosis factor-mediated signaling pathway|TOR signaling|signal transduction by p53 class mediator|regulation of proteolysis|regulation of extrinsic apoptotic signaling pathway|regulation of peptidase activity|negative regulation of tumor necrosis factor-mediated signaling pathway|proteolysis involved in cellular protein catabolic process|regulation of fibroblast migration|regulation of signal transduction by p53 class mediator|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of proteolysis|transition metal ion binding|negative regulation of apoptotic process|response to tumor necrosis factor|negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis|protein kinase binding|cellular protein modification process|extrinsic apoptotic signaling pathway|fibroblast migration|apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|modification-dependent protein catabolic process|cellular response to tumor necrosis factor|negative regulation of endopeptidase activity|tumor necrosis factor-mediated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|zinc ion binding|extrinsic apoptotic signaling pathway via death domain receptors|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of endopeptidase activity|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|negative regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination|protein K48-linked ubiquitination - - - - 17:35005990-35089319 173 218 266 544 583 460 0.674240749757476 0.772156024971744 0.934682897666646 1.89961596089814 1.86425747785649 1.68017910624088 0.793693224131955 1.81468418166517 -1.19306509665408 5.33711433755443e-07 7.02222174673203e-06 DOWN ENSG00000119778 ATAD2B ATPase family, AAA domain containing 2B [Source:HGNC Symbol;Acc:HGNC:29230] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:0042393|GO:1901360|GO:0034641|GO:0043168|GO:0001882|GO:0031325|GO:0046483|GO:0051128|GO:0016817|GO:0043231|GO:0009890|GO:0003682|GO:0016458|GO:0006139|GO:0060968|GO:0000166|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0035639|GO:0010629|GO:0070577|GO:0051252|GO:0006325|GO:0001883|GO:0010628|GO:0031936|GO:0016818|GO:0032549|GO:0006342|GO:0033043|GO:0010467|GO:0017076|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045814|GO:0045893|GO:2001251|GO:0045892|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0033044|GO:1902679|GO:0040029|GO:0045815|GO:0016568|GO:0016462|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0017111|GO:0016887 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|negative regulation of biosynthetic process|chromatin binding|gene silencing|nucleobase-containing compound metabolic process|regulation of gene silencing|nucleotide binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|negative regulation of gene expression|lysine-acetylated histone binding|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|positive regulation of gene expression|negative regulation of chromatin silencing|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|chromatin silencing|regulation of organelle organization|gene expression|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|negative regulation of gene expression, epigenetic|positive regulation of transcription, DNA-templated|negative regulation of chromosome organization|negative regulation of transcription, DNA-templated|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|regulation of chromosome organization|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|positive regulation of gene expression, epigenetic|chromatin modification|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|ATPase activity - - - - 2:23748664-23927114 194 227 281 520 592 531 0.852411567267097 0.906469221480008 1.11318707663688 2.04714288750539 2.13420770146957 2.18660620851255 0.957355955127995 2.12265226582917 -1.14874070849793 5.37518502390994e-07 7.06919707946288e-06 DOWN ENSG00000104907 TRMT1 tRNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:25980] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0008168|GO:0046872|GO:0003723|GO:0043412|GO:0001510|GO:0031981|GO:0005654|GO:0005739|GO:0010467|GO:0016070|GO:0005634|GO:0000049|GO:0006396|GO:0034660|GO:0009451|GO:0044822|GO:0030488|GO:0008173|GO:0008757|GO:0008170|GO:0006400|GO:0016423|GO:0006399|GO:0002940|GO:0008175|GO:0004809|GO:0008033 cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|methyltransferase activity|metal ion binding|RNA binding|macromolecule modification|RNA methylation|nuclear lumen|nucleoplasm|mitochondrion|gene expression|RNA metabolic process|nucleus|tRNA binding|RNA processing|ncRNA metabolic process|RNA modification|poly(A) RNA binding|tRNA methylation|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|N-methyltransferase activity|tRNA modification|tRNA (guanine) methyltransferase activity|tRNA metabolic process|tRNA N2-guanine methylation|tRNA methyltransferase activity|tRNA (guanine-N2-)-methyltransferase activity|tRNA processing - - - - 19:13104902-13117567 1782 1788 1452 866 995 569 11.8049297749703 10.7647328915534 8.67234768294563 5.14009729625113 5.40812674543344 3.53261975484159 10.4140034498231 4.69361459884205 1.14975350021332 5.37784144615185e-07 7.06957633348382e-06 UP ENSG00000123607 TTC21B tetratricopeptide repeat domain 21B [Source:HGNC Symbol;Acc:HGNC:25660] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0030990|GO:0030900|GO:0046483|GO:0007420|GO:0043231|GO:0005737|GO:0007389|GO:0060322|GO:0006928|GO:0030991|GO:0009966|GO:0045184|GO:0072372|GO:0010646|GO:0006139|GO:0000790|GO:0008104|GO:0007154|GO:0010970|GO:0007165|GO:0051649|GO:0097542|GO:0030030|GO:0048869|GO:0044249|GO:0007017|GO:0031323|GO:0006996|GO:0000902|GO:0010468|GO:0034645|GO:0007166|GO:0007417|GO:0051252|GO:0015031|GO:0008589|GO:0044782|GO:0046907|GO:0021871|GO:0003002|GO:0031981|GO:0007018|GO:0005694|GO:0000228|GO:0034613|GO:0021591|GO:0010467|GO:0032990|GO:0031503|GO:0007399|GO:0009059|GO:0048858|GO:0016070|GO:0005856|GO:0005634|GO:0060271|GO:0021798|GO:0033365|GO:0042073|GO:0032774|GO:2001141|GO:0007224|GO:0006886|GO:0009953|GO:0030705|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0061512|GO:0035735|GO:0035721 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|cilium|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|intraciliary transport particle|forebrain development|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|head development|movement of cell or subcellular component|intraciliary transport particle A|regulation of signal transduction|establishment of protein localization|primary cilium|regulation of cell communication|nucleobase-containing compound metabolic process|nuclear chromatin|protein localization|cell communication|establishment of localization by movement along microtubule|signal transduction|establishment of localization in cell|ciliary tip|cell projection organization|cellular developmental process|cellular biosynthetic process|microtubule-based process|regulation of cellular metabolic process|organelle organization|cell morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|central nervous system development|regulation of RNA metabolic process|protein transport|regulation of smoothened signaling pathway|cilium organization|intracellular transport|forebrain regionalization|regionalization|nuclear lumen|microtubule-based movement|chromosome|nuclear chromosome|cellular protein localization|ventricular system development|gene expression|cell part morphogenesis|protein complex localization|nervous system development|macromolecule biosynthetic process|cell projection morphogenesis|RNA metabolic process|cytoskeleton|nucleus|cilium morphogenesis|forebrain dorsal/ventral pattern formation|protein localization to organelle|intraciliary transport|RNA biosynthetic process|regulation of RNA biosynthetic process|smoothened signaling pathway|intracellular protein transport|dorsal/ventral pattern formation|cytoskeleton-dependent intracellular transport|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|protein localization to cilium|intraciliary transport involved in cilium morphogenesis|intraciliary retrograde transport - - - - 2:165857475-165953843 68 72 104 195 230 266 0.523005443440461 0.503282130009025 0.72118268594074 1.3437913982771 1.45142854527092 1.91738548328101 0.582490086463409 1.57086847560968 -1.43125699137851 5.38056340278084e-07 7.07004136560824e-06 DOWN ENSG00000184162 NR2C2AP nuclear receptor 2C2-associated protein [Source:HGNC Symbol;Acc:HGNC:30763] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0006139|GO:0070062|GO:0044249|GO:0034645|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0006351|GO:0006366|GO:0006352|GO:0006367 cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|extracellular exosome|cellular biosynthetic process|cellular macromolecule biosynthetic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|transcription initiation from RNA polymerase II promoter - - - - 19:19201416-19203424 432 447 428 243 213 146 5.12207352891957 4.81670373013777 4.57530540105636 2.58146198100209 2.07209525835823 1.62234623028892 4.83802755337123 2.09196782321641 1.20955832422246 5.4410691440651e-07 7.14325761771854e-06 UP ENSG00000138161 CUZD1 CUB and zona pellucida-like domains 1 [Source:HGNC Symbol;Acc:HGNC:17937] GO:0040011|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0008283|GO:0043229|GO:0071704|GO:0048870|GO:0007155|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0007049|GO:0031982|GO:0030141|GO:0043231|GO:0030133|GO:0005737|GO:0012506|GO:0006928|GO:0031589|GO:0030658|GO:0016477|GO:0030667|GO:0051301|GO:0016021|GO:0019538|GO:0031410|GO:0051604|GO:0016023|GO:0042588|GO:0006508|GO:0031988|GO:0006931|GO:0030659|GO:0006929|GO:0010467|GO:0042589|GO:0016485|GO:0031638|GO:0032023 locomotion|cell|membrane|cellular process|metabolic process|cell proliferation|intracellular organelle|organic substance metabolic process|cell motility|cell adhesion|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|cell cycle|vesicle|secretory granule|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|vesicle membrane|movement of cell or subcellular component|cell-substrate adhesion|transport vesicle membrane|cell migration|secretory granule membrane|cell division|integral component of membrane|protein metabolic process|cytoplasmic vesicle|protein maturation|cytoplasmic, membrane-bounded vesicle|zymogen granule|proteolysis|membrane-bounded vesicle|substrate-dependent cell migration, cell attachment to substrate|cytoplasmic vesicle membrane|substrate-dependent cell migration|gene expression|zymogen granule membrane|protein processing|zymogen activation|trypsinogen activation - - - - 10:122832149-122850793 140 138 104 45 53 49 1.82378685808202 1.63382093681613 1.22149487340644 0.525237972373756 0.566485132770758 0.598236579007477 1.55970088943486 0.56331989471733 1.4692430546454 5.49712134552654e-07 7.21050354346877e-06 UP ENSG00000197535 MYO5A myosin VA [Source:HGNC Symbol;Acc:HGNC:7602] GO:0040011|GO:0032502|GO:0032991|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0048523|GO:0031987|GO:0044877|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0030427|GO:0043473|GO:0043227|GO:0031252|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0007626|GO:0048856|GO:0005929|GO:0060341|GO:0044255|GO:0051282|GO:0006725|GO:0051640|GO:0009888|GO:0043025|GO:0006810|GO:1901360|GO:0005884|GO:0006082|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0043168|GO:0005874|GO:0044281|GO:0032940|GO:0048066|GO:0001882|GO:0031982|GO:0030426|GO:0016817|GO:0005882|GO:0030141|GO:0043231|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0007267|GO:0001726|GO:0006928|GO:0009887|GO:0032403|GO:0042592|GO:0051656|GO:0043005|GO:0009966|GO:0045184|GO:0072372|GO:0019725|GO:0036477|GO:0016459|GO:0033059|GO:0010646|GO:0006582|GO:0008104|GO:0005516|GO:0007154|GO:0055085|GO:0061024|GO:0001750|GO:0006629|GO:0007165|GO:0005783|GO:0070062|GO:0050808|GO:0051649|GO:0032433|GO:0008092|GO:2000021|GO:0009725|GO:0000166|GO:0051238|GO:0010817|GO:0048869|GO:0030029|GO:0044249|GO:0010469|GO:0019538|GO:0010033|GO:0010256|GO:0005794|GO:0005768|GO:0016192|GO:0051650|GO:0005829|GO:1990752|GO:0046872|GO:0003723|GO:0035639|GO:0031410|GO:0005769|GO:0044550|GO:0048878|GO:0006631|GO:0030048|GO:0032386|GO:0001883|GO:0003779|GO:0051904|GO:0051875|GO:0015031|GO:1901652|GO:0005773|GO:0071417|GO:0051208|GO:0007009|GO:0016023|GO:0006887|GO:0051643|GO:0016818|GO:0046907|GO:0042886|GO:0006811|GO:0051209|GO:0032549|GO:0055082|GO:0007600|GO:0051279|GO:0055037|GO:0005770|GO:0072657|GO:0031585|GO:0043434|GO:0009914|GO:0009306|GO:0031988|GO:0034765|GO:0030175|GO:0018958|GO:0043269|GO:0034613|GO:0032593|GO:0042438|GO:0042641|GO:0051015|GO:0050931|GO:0035371|GO:0060429|GO:0035556|GO:0042476|GO:0044267|GO:0008610|GO:0007399|GO:0046903|GO:0071310|GO:0017076|GO:0051648|GO:0010522|GO:0051020|GO:0030154|GO:1902531|GO:0032870|GO:0005856|GO:0022898|GO:0031513|GO:0008366|GO:0034220|GO:0002790|GO:0015629|GO:0050953|GO:0030073|GO:0098655|GO:0032400|GO:0030855|GO:1901653|GO:0000323|GO:0005777|GO:0072659|GO:0005524|GO:0006812|GO:0030050|GO:0001676|GO:0032402|GO:0030554|GO:0015833|GO:0048193|GO:0060402|GO:0005509|GO:0016482|GO:0032412|GO:0015630|GO:0006633|GO:0031267|GO:0071375|GO:0032252|GO:0045111|GO:0050801|GO:0019752|GO:0044822|GO:0032868|GO:0030318|GO:0042552|GO:0030705|GO:0019932|GO:0050848|GO:1990778|GO:0016462|GO:0046879|GO:0006873|GO:0090279|GO:1903169|GO:0032401|GO:0030072|GO:0017016|GO:0005764|GO:0017111|GO:0042470|GO:0032869|GO:1901019|GO:0032787|GO:0030001|GO:0019722|GO:0051924|GO:2001257|GO:0006892|GO:0007601|GO:0030003|GO:0007268|GO:0042759|GO:0017137|GO:0070588|GO:0055065|GO:0060563|GO:0097553|GO:0006875|GO:0003774|GO:0000146|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 locomotion|developmental process|macromolecular complex|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of cellular process|locomotion involved in locomotory behavior|macromolecular complex binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|site of polarized growth|pigmentation|membrane-bounded organelle|cell leading edge|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|endomembrane system|locomotory behavior|anatomical structure development|cilium|regulation of cellular localization|cellular lipid metabolic process|regulation of sequestering of calcium ion|cellular aromatic compound metabolic process|organelle localization|tissue development|neuronal cell body|transport|organic cyclic compound metabolic process|actin filament|organic acid metabolic process|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|anion binding|microtubule|small molecule metabolic process|secretion by cell|developmental pigmentation|nucleoside binding|vesicle|growth cone|hydrolase activity, acting on acid anhydrides|intermediate filament|secretory granule|intracellular membrane-bounded organelle|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|cell-cell signaling|ruffle|movement of cell or subcellular component|organ morphogenesis|protein complex binding|homeostatic process|establishment of organelle localization|neuron projection|regulation of signal transduction|establishment of protein localization|primary cilium|cellular homeostasis|somatodendritic compartment|myosin complex|cellular pigmentation|regulation of cell communication|melanin metabolic process|protein localization|calmodulin binding|cell communication|transmembrane transport|membrane organization|photoreceptor outer segment|lipid metabolic process|signal transduction|endoplasmic reticulum|extracellular exosome|synapse organization|establishment of localization in cell|filopodium tip|cytoskeletal protein binding|regulation of ion homeostasis|response to hormone|nucleotide binding|sequestering of metal ion|regulation of hormone levels|cellular developmental process|actin filament-based process|cellular biosynthetic process|regulation of receptor activity|protein metabolic process|response to organic substance|endomembrane system organization|Golgi apparatus|endosome|vesicle-mediated transport|establishment of vesicle localization|cytosol|microtubule end|metal ion binding|RNA binding|purine ribonucleoside triphosphate binding|cytoplasmic vesicle|early endosome|secondary metabolite biosynthetic process|chemical homeostasis|fatty acid metabolic process|actin filament-based movement|regulation of intracellular transport|purine nucleoside binding|actin binding|pigment granule transport|pigment granule localization|protein transport|response to peptide|vacuole|cellular response to organonitrogen compound|sequestering of calcium ion|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|exocytosis|endoplasmic reticulum localization|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|amide transport|ion transport|release of sequestered calcium ion into cytosol|ribonucleoside binding|cellular chemical homeostasis|sensory perception|regulation of release of sequestered calcium ion into cytosol|recycling endosome|late endosome|protein localization to membrane|regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|response to peptide hormone|hormone transport|protein secretion|membrane-bounded vesicle|regulation of ion transmembrane transport|filopodium|phenol-containing compound metabolic process|regulation of ion transport|cellular protein localization|insulin-responsive compartment|melanin biosynthetic process|actomyosin|actin filament binding|pigment cell differentiation|microtubule plus-end|epithelium development|intracellular signal transduction|odontogenesis|cellular protein metabolic process|lipid biosynthetic process|nervous system development|secretion|cellular response to organic substance|purine nucleotide binding|vesicle localization|regulation of calcium ion transport into cytosol|GTPase binding|cell differentiation|regulation of intracellular signal transduction|cellular response to hormone stimulus|cytoskeleton|regulation of transmembrane transporter activity|nonmotile primary cilium|axon ensheathment|ion transmembrane transport|peptide secretion|actin cytoskeleton|sensory perception of light stimulus|insulin secretion|cation transmembrane transport|melanosome localization|epithelial cell differentiation|cellular response to peptide|lytic vacuole|peroxisome|protein localization to plasma membrane|ATP binding|cation transport|vesicle transport along actin filament|long-chain fatty acid metabolic process|melanosome transport|adenyl nucleotide binding|peptide transport|Golgi vesicle transport|calcium ion transport into cytosol|calcium ion binding|cytosolic transport|regulation of ion transmembrane transporter activity|microtubule cytoskeleton|fatty acid biosynthetic process|small GTPase binding|cellular response to peptide hormone stimulus|secretory granule localization|intermediate filament cytoskeleton|ion homeostasis|carboxylic acid metabolic process|poly(A) RNA binding|response to insulin|melanocyte differentiation|myelination|cytoskeleton-dependent intracellular transport|second-messenger-mediated signaling|regulation of calcium-mediated signaling|protein localization to cell periphery|pyrophosphatase activity|hormone secretion|cellular ion homeostasis|regulation of calcium ion import|regulation of calcium ion transmembrane transport|establishment of melanosome localization|peptide hormone secretion|Ras GTPase binding|lysosome|nucleoside-triphosphatase activity|melanosome|cellular response to insulin stimulus|regulation of calcium ion transmembrane transporter activity|monocarboxylic acid metabolic process|metal ion transport|calcium-mediated signaling|regulation of calcium ion transport|regulation of cation channel activity|post-Golgi vesicle-mediated transport|visual perception|cellular cation homeostasis|synaptic transmission|long-chain fatty acid biosynthetic process|Rab GTPase binding|calcium ion transmembrane transport|metal ion homeostasis|neuroepithelial cell differentiation|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|motor activity|microfilament motor activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration - - - - 15:52307283-52529050 300 375 471 741 946 916 0.754741359273144 0.857408994711702 1.06834636996778 1.67029344828642 1.95270120512262 2.15973818597408 0.893498907984209 1.92757761312771 -1.1092510796896 5.51678208587213e-07 7.23311429036568e-06 DOWN ENSG00000106541 AGR2 anterior gradient 2, protein disulphide isomerase family member [Source:HGNC Symbol;Acc:HGNC:328] GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0043227|GO:0040008|GO:0009893|GO:0005615|GO:0050793|GO:0048589|GO:0005622|GO:1903829|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0042802|GO:0060341|GO:0048565|GO:0035239|GO:0009888|GO:0006810|GO:0035295|GO:0051130|GO:0010941|GO:0007275|GO:0030324|GO:0048513|GO:0005102|GO:0030155|GO:0051128|GO:0033554|GO:0043231|GO:0005737|GO:0032880|GO:0031589|GO:0009966|GO:0046983|GO:0045184|GO:0048639|GO:0030323|GO:0060548|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0090004|GO:0005783|GO:0048638|GO:0045785|GO:0008219|GO:0001948|GO:0048869|GO:0009967|GO:0010033|GO:0010256|GO:0050878|GO:0060479|GO:0010468|GO:0090150|GO:0055123|GO:0007166|GO:0030968|GO:0070851|GO:0007589|GO:0006984|GO:0060541|GO:1900101|GO:0010628|GO:0007009|GO:0070201|GO:0006986|GO:0072657|GO:1901184|GO:0070254|GO:0010810|GO:0060433|GO:0005739|GO:0034613|GO:0060429|GO:1903078|GO:0010467|GO:0046903|GO:0071310|GO:0002162|GO:0010811|GO:0030154|GO:0035967|GO:1903827|GO:0048546|GO:0034976|GO:0060428|GO:1901186|GO:0042803|GO:1900103|GO:0034620|GO:0060481|GO:0090003|GO:1903897|GO:0045742|GO:0030855|GO:0036498|GO:0005154|GO:0060487|GO:0072659|GO:0090002|GO:0042058|GO:0060482|GO:1903894|GO:0036499|GO:0007167|GO:1903899|GO:1903896|GO:1903076|GO:1990778|GO:0061140|GO:0060480|GO:0007169|GO:0002067|GO:0038127|GO:0007173 developmental process|growth|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|extracellular space|regulation of developmental process|developmental growth|intracellular|positive regulation of cellular protein localization|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cellular localization|digestive tract development|tube morphogenesis|tissue development|transport|tube development|positive regulation of cellular component organization|regulation of cell death|multicellular organism development|lung development|animal organ development|receptor binding|regulation of cell adhesion|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|cell-substrate adhesion|regulation of signal transduction|protein dimerization activity|establishment of protein localization|positive regulation of developmental growth|respiratory tube development|negative regulation of cell death|regulation of cell communication|protein localization|cell communication|membrane organization|signal transduction|positive regulation of establishment of protein localization to plasma membrane|endoplasmic reticulum|regulation of developmental growth|positive regulation of cell adhesion|cell death|glycoprotein binding|cellular developmental process|positive regulation of signal transduction|response to organic substance|endomembrane system organization|regulation of body fluid levels|lung cell differentiation|regulation of gene expression|establishment of protein localization to membrane|digestive system development|cell surface receptor signaling pathway|endoplasmic reticulum unfolded protein response|growth factor receptor binding|body fluid secretion|ER-nucleus signaling pathway|respiratory system development|regulation of endoplasmic reticulum unfolded protein response|positive regulation of gene expression|plasma membrane organization|regulation of establishment of protein localization|response to unfolded protein|protein localization to membrane|regulation of ERBB signaling pathway|mucus secretion|regulation of cell-substrate adhesion|bronchus development|mitochondrion|cellular protein localization|epithelium development|positive regulation of protein localization to plasma membrane|gene expression|secretion|cellular response to organic substance|dystroglycan binding|positive regulation of cell-substrate adhesion|cell differentiation|cellular response to topologically incorrect protein|regulation of cellular protein localization|digestive tract morphogenesis|response to endoplasmic reticulum stress|lung epithelium development|positive regulation of ERBB signaling pathway|protein homodimerization activity|positive regulation of endoplasmic reticulum unfolded protein response|cellular response to unfolded protein|lobar bronchus epithelium development|regulation of establishment of protein localization to plasma membrane|regulation of PERK-mediated unfolded protein response|positive regulation of epidermal growth factor receptor signaling pathway|epithelial cell differentiation|IRE1-mediated unfolded protein response|epidermal growth factor receptor binding|lung epithelial cell differentiation|protein localization to plasma membrane|establishment of protein localization to plasma membrane|regulation of epidermal growth factor receptor signaling pathway|lobar bronchus development|regulation of IRE1-mediated unfolded protein response|PERK-mediated unfolded protein response|enzyme linked receptor protein signaling pathway|positive regulation of PERK-mediated unfolded protein response|positive regulation of IRE1-mediated unfolded protein response|regulation of protein localization to plasma membrane|protein localization to cell periphery|lung secretory cell differentiation|lung goblet cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|glandular epithelial cell differentiation|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 7:16791811-16833433 605 632 836 1526 1390 1887 10.9536284982291 10.3991901109003 13.6465446004157 24.7545203606899 20.6483418618477 32.0186656675438 11.6664544031817 25.8071759633605 -1.14540610564833 5.6447927649761e-07 7.38797208266534e-06 DOWN ENSG00000159714 ZDHHC1 zinc finger, DHHC-type containing 1 [Source:HGNC Symbol;Acc:HGNC:17916] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0003676|GO:0031982|GO:0043231|GO:0043169|GO:0016746|GO:0005737|GO:0005783|GO:0070062|GO:0016021|GO:0044249|GO:0019538|GO:0003677|GO:0034645|GO:0046872|GO:0043412|GO:0036211|GO:0042157|GO:0016747|GO:0044267|GO:0009059|GO:0016409|GO:0042158|GO:0046914|GO:0006464|GO:0019706|GO:0006497|GO:0008270|GO:0018345 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|nucleic acid binding|vesicle|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|cytoplasm|endoplasmic reticulum|extracellular exosome|integral component of membrane|cellular biosynthetic process|protein metabolic process|DNA binding|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|protein modification process|lipoprotein metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein metabolic process|macromolecule biosynthetic process|palmitoyltransferase activity|lipoprotein biosynthetic process|transition metal ion binding|cellular protein modification process|protein-cysteine S-palmitoyltransferase activity|protein lipidation|zinc ion binding|protein palmitoylation - - - - 16:67394419-67416833 30 25 52 101 123 175 0.425777116652057 0.322474513770989 0.665407695721381 1.28435828642619 1.43232274506057 2.32774604591876 0.471219775381476 1.68147569246851 -1.83525593309441 5.64477031713052e-07 7.38797208266534e-06 DOWN ENSG00000122068 FYTTD1 forty-two-three domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25407] GO:0005623|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0071704|GO:0051641|GO:0043227|GO:0005622|GO:0005515|GO:0006810|GO:0003676|GO:0071166|GO:0043231|GO:0051649|GO:0006403|GO:0003723|GO:0046907|GO:0031981|GO:0005654|GO:0050658|GO:0010467|GO:0005634|GO:0051028|GO:0051169|GO:0016604|GO:0044822|GO:0006406|GO:0006405|GO:0016607|GO:0006913|GO:0003729|GO:0051168 cell|metabolic process|binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|cellular localization|membrane-bounded organelle|intracellular|protein binding|transport|nucleic acid binding|ribonucleoprotein complex localization|intracellular membrane-bounded organelle|establishment of localization in cell|RNA localization|RNA binding|intracellular transport|nuclear lumen|nucleoplasm|RNA transport|gene expression|nucleus|mRNA transport|nuclear transport|nuclear body|poly(A) RNA binding|mRNA export from nucleus|RNA export from nucleus|nuclear speck|nucleocytoplasmic transport|mRNA binding|nuclear export - - - - 3:197737179-197787596 1566 2404 1855 976 1194 881 11.1174154888439 15.5105235594169 11.8732620087771 6.20810881606515 6.95479338027059 5.86160933558926 12.8337336856793 6.341503843975 1.01704403986653 5.65091532821359e-07 7.39274435620019e-06 UP ENSG00000268592 RAET1E-AS1 RAET1E antisense RNA 1 [Source:EntrezGene;Acc:100652739] - - - - - - 6:149863494-149919507 20 21 53 82 159 199 1.16920456191091 1.11575518042837 2.79350134983075 4.29507236291265 7.62648166350053 10.9028803433266 1.69282036405668 7.60814478991326 -2.1681158144556 5.66840474747375e-07 7.41237649282003e-06 DOWN ENSG00000097021 ACOT7 acyl-CoA thioesterase 7 [Source:HGNC Symbol;Acc:HGNC:24157] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0042802|GO:0044255|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0016788|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0046983|GO:0051186|GO:0006139|GO:0055086|GO:0006629|GO:0070062|GO:0050662|GO:0000062|GO:0044249|GO:0006790|GO:0005829|GO:0046486|GO:0036042|GO:0019693|GO:0006637|GO:0006631|GO:0009116|GO:0016790|GO:0006638|GO:0031981|GO:0005654|GO:0005739|GO:0006796|GO:1901137|GO:0008610|GO:0005634|GO:0052689|GO:0042803|GO:0015936|GO:0036116|GO:0009259|GO:0009117|GO:0046390|GO:0001676|GO:0051791|GO:0009108|GO:0006633|GO:0036114|GO:0006163|GO:0019752|GO:0006639|GO:0009165|GO:0042278|GO:0051792|GO:0006164|GO:0015937|GO:0046949|GO:0047617|GO:0032787|GO:0035336|GO:0006641|GO:0036112|GO:0042759|GO:0019432|GO:1900535|GO:0009152|GO:0035338|GO:0016290 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|hydrolase activity|biosynthetic process|intracellular|protein binding|identical protein binding|cellular lipid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|lipid metabolic process|extracellular exosome|coenzyme binding|fatty-acyl-CoA binding|cellular biosynthetic process|sulfur compound metabolic process|cytosol|glycerolipid metabolic process|long-chain fatty acyl-CoA binding|ribose phosphate metabolic process|acyl-CoA metabolic process|fatty acid metabolic process|nucleoside metabolic process|thiolester hydrolase activity|neutral lipid metabolic process|nuclear lumen|nucleoplasm|mitochondrion|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|lipid biosynthetic process|nucleus|carboxylic ester hydrolase activity|protein homodimerization activity|coenzyme A metabolic process|long-chain fatty-acyl-CoA catabolic process|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|long-chain fatty acid metabolic process|medium-chain fatty acid metabolic process|coenzyme biosynthetic process|fatty acid biosynthetic process|medium-chain fatty-acyl-CoA catabolic process|purine nucleotide metabolic process|carboxylic acid metabolic process|acylglycerol metabolic process|nucleotide biosynthetic process|purine nucleoside metabolic process|medium-chain fatty acid biosynthetic process|purine nucleotide biosynthetic process|coenzyme A biosynthetic process|fatty-acyl-CoA biosynthetic process|acyl-CoA hydrolase activity|monocarboxylic acid metabolic process|long-chain fatty-acyl-CoA metabolic process|triglyceride metabolic process|medium-chain fatty-acyl-CoA metabolic process|long-chain fatty acid biosynthetic process|triglyceride biosynthetic process|palmitic acid biosynthetic process|purine ribonucleotide biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|palmitoyl-CoA hydrolase activity K17360 acyl-coenzyme A thioesterase 7[3.1.2.2] hsa00062|hsa01040 Fatty acid elongation - Homo sapiens (human)|Biosynthesis of unsaturated fatty acids - Homo sapiens (human) 1:6264269-6394391 431 509 630 1178 1400 963 5.50019668790554 5.90334966316151 7.2486207440501 13.4692664190116 14.6587431577373 11.5174475389299 6.21738903170572 13.2151523718929 -1.08781230099287 5.71037652938039e-07 7.46399215884948e-06 DOWN ENSG00000187535 IFT140 intraflagellar transport 140 [Source:HGNC Symbol;Acc:HGNC:29077] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0007507|GO:0060041|GO:0009888|GO:0048468|GO:1902115|GO:0006810|GO:0035295|GO:0005930|GO:0007275|GO:0048513|GO:0030990|GO:0051128|GO:0022607|GO:0007389|GO:0007423|GO:0006928|GO:0009887|GO:0021915|GO:0030991|GO:0009966|GO:0045184|GO:0072372|GO:0036064|GO:0010646|GO:0008104|GO:0007154|GO:0001750|GO:0010970|GO:0060491|GO:0007165|GO:0051649|GO:0097542|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0005813|GO:0048705|GO:0031344|GO:0007166|GO:0001654|GO:0072358|GO:0001655|GO:0005815|GO:0015031|GO:0008589|GO:0009790|GO:1902017|GO:0044782|GO:0046907|GO:0072001|GO:0003002|GO:0021532|GO:0030031|GO:0007018|GO:0022604|GO:0034613|GO:0070925|GO:0060429|GO:0042384|GO:0033043|GO:0035108|GO:0032990|GO:0031503|GO:0007399|GO:0030154|GO:0001501|GO:0048858|GO:0060173|GO:0072359|GO:0005856|GO:0031513|GO:0048666|GO:0030182|GO:0060271|GO:0042461|GO:0033365|GO:0009792|GO:0042073|GO:0032391|GO:0043010|GO:0007224|GO:0006886|GO:0015630|GO:0009855|GO:0035845|GO:0022008|GO:0030705|GO:0048699|GO:0007368|GO:0061512|GO:0035721|GO:0043009 developmental process|macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|heart development|retina development in camera-type eye|tissue development|cell development|regulation of organelle assembly|transport|tube development|axoneme|multicellular organism development|animal organ development|intraciliary transport particle|regulation of cellular component organization|cellular component assembly|pattern specification process|sensory organ development|movement of cell or subcellular component|organ morphogenesis|neural tube development|intraciliary transport particle A|regulation of signal transduction|establishment of protein localization|primary cilium|ciliary basal body|regulation of cell communication|protein localization|cell communication|photoreceptor outer segment|establishment of localization by movement along microtubule|regulation of cell projection assembly|signal transduction|establishment of localization in cell|ciliary tip|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|centrosome|skeletal system morphogenesis|regulation of cell projection organization|cell surface receptor signaling pathway|eye development|cardiovascular system development|urogenital system development|microtubule organizing center|protein transport|regulation of smoothened signaling pathway|embryo development|regulation of cilium assembly|cilium organization|intracellular transport|renal system development|regionalization|neural tube patterning|cell projection assembly|microtubule-based movement|regulation of cell morphogenesis|cellular protein localization|organelle assembly|epithelium development|cilium assembly|regulation of organelle organization|limb morphogenesis|cell part morphogenesis|protein complex localization|nervous system development|cell differentiation|skeletal system development|cell projection morphogenesis|limb development|circulatory system development|cytoskeleton|nonmotile primary cilium|neuron development|neuron differentiation|cilium morphogenesis|photoreceptor cell development|protein localization to organelle|embryo development ending in birth or egg hatching|intraciliary transport|photoreceptor connecting cilium|camera-type eye development|smoothened signaling pathway|intracellular protein transport|microtubule cytoskeleton|determination of bilateral symmetry|photoreceptor cell outer segment organization|neurogenesis|cytoskeleton-dependent intracellular transport|generation of neurons|determination of left/right symmetry|protein localization to cilium|intraciliary retrograde transport|chordate embryonic development - - - - 16:1510427-1612110 107 127 173 310 350 504 0.667506453009313 0.720038609110124 0.973040182365254 1.73272979327968 1.79145897617378 2.94665986053829 0.786861748161564 2.15694954333058 -1.45481034732522 5.74642977563532e-07 7.50454569211798e-06 DOWN ENSG00000144647 POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) [Source:HGNC Symbol;Acc:HGNC:25902] GO:0040011|GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0048870|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0006486|GO:0007275|GO:0043231|GO:0005737|GO:0005975|GO:0006928|GO:0016477|GO:0005783|GO:0016757|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0034645|GO:0043412|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0001764|GO:0016758|GO:0070085|GO:0035268|GO:1901137|GO:0044267|GO:0007399|GO:0009059|GO:0030154|GO:0097502|GO:0009101|GO:0043413|GO:0008375|GO:0097363|GO:0022008|GO:0006464|GO:0035269|GO:0048699 locomotion|developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cell motility|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|protein glycosylation|multicellular organism development|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|movement of cell or subcellular component|cell migration|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|neuron migration|transferase activity, transferring hexosyl groups|glycosylation|protein mannosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|nervous system development|macromolecule biosynthetic process|cell differentiation|mannosylation|glycoprotein biosynthetic process|macromolecule glycosylation|acetylglucosaminyltransferase activity|protein O-GlcNAc transferase activity|neurogenesis|cellular protein modification process|protein O-linked mannosylation|generation of neurons - - - - 3:43079232-43106076 118 160 174 371 439 333 1.6447207869117 2.02679178968495 2.18662345891886 4.63320095359312 5.02044767972066 4.34993169734893 1.9527120118385 4.6678601102209 -1.25728213134619 5.79293462122352e-07 7.56197071193734e-06 DOWN ENSG00000206573 THUMPD3-AS1 THUMPD3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44478] - - - - - - 3:9349689-9398579 101 99 104 279 261 263 0.415254536064145 0.36991998433512 0.385511023690613 1.02776220600363 0.880437935895759 1.01338779736137 0.390228514696626 0.973862646420253 -1.31939910684882 5.81220283130923e-07 7.58049381065556e-06 DOWN ENSG00000131069 ACSS2 acyl-CoA synthetase short-chain family member 2 [Source:HGNC Symbol;Acc:HGNC:15814] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0044255|GO:0006082|GO:0009410|GO:0043168|GO:0044281|GO:0001882|GO:0043231|GO:0043169|GO:0005737|GO:0051186|GO:0006629|GO:0006805|GO:0000166|GO:0044249|GO:0006790|GO:0055114|GO:0005829|GO:0006069|GO:0035639|GO:0016208|GO:0006637|GO:0006066|GO:0006631|GO:0001883|GO:0032549|GO:0071466|GO:0031981|GO:0016878|GO:0005654|GO:0019427|GO:0008610|GO:0017076|GO:0005634|GO:0005524|GO:0003987|GO:0030554|GO:0046459|GO:0009108|GO:0006633|GO:0019752|GO:0006084|GO:0006067|GO:0006085|GO:0032787|GO:0051790|GO:0019413|GO:0019542|GO:0006083 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|anion binding|small molecule metabolic process|nucleoside binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|cofactor metabolic process|lipid metabolic process|xenobiotic metabolic process|nucleotide binding|cellular biosynthetic process|sulfur compound metabolic process|oxidation-reduction process|cytosol|ethanol oxidation|purine ribonucleoside triphosphate binding|AMP binding|acyl-CoA metabolic process|alcohol metabolic process|fatty acid metabolic process|purine nucleoside binding|ribonucleoside binding|cellular response to xenobiotic stimulus|nuclear lumen|acid-thiol ligase activity|nucleoplasm|acetyl-CoA biosynthetic process from acetate|lipid biosynthetic process|purine nucleotide binding|nucleus|ATP binding|acetate-CoA ligase activity|adenyl nucleotide binding|short-chain fatty acid metabolic process|coenzyme biosynthetic process|fatty acid biosynthetic process|carboxylic acid metabolic process|acetyl-CoA metabolic process|ethanol metabolic process|acetyl-CoA biosynthetic process|monocarboxylic acid metabolic process|short-chain fatty acid biosynthetic process|acetate biosynthetic process|propionate biosynthetic process|acetate metabolic process K01895 acetyl-CoA synthetase[6.2.1.1] hsa01100|hsa01200|hsa00010|hsa00620|hsa00640 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human)|Pyruvate metabolism - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human) 20:34872146-34927962 198 245 386 599 691 835 1.39390008690542 1.5675178576861 2.45000602977648 3.77825242897682 3.99127887129831 5.5091141071541 1.803807991456 4.42621513580974 -1.29502779758164 5.83159407430205e-07 7.60246329669054e-06 DOWN ENSG00000198964 SGMS1 sphingomyelin synthase 1 [Source:HGNC Symbol;Acc:HGNC:29799] GO:0040007|GO:0023052|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0006950|GO:0016049|GO:0071704|GO:0023051|GO:0051707|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0031224|GO:0005515|GO:0016740|GO:0019222|GO:0010941|GO:0006952|GO:0016772|GO:0009966|GO:0060548|GO:0010646|GO:0009617|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0016021|GO:0010033|GO:0010468|GO:0007166|GO:0033993|GO:0034097|GO:0002237|GO:0043069|GO:2001234|GO:0010628|GO:0016780|GO:0071219|GO:0006954|GO:0012501|GO:0010467|GO:0071310|GO:0032496|GO:0043067|GO:0097190|GO:2001237|GO:2001236|GO:0033188|GO:0042981|GO:0071345|GO:0043066|GO:0034612|GO:0071396|GO:0097191|GO:0006915|GO:0071222|GO:0071356 growth|signaling|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|response to stress|cell growth|organic substance metabolic process|regulation of signaling|response to other organism|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|protein binding|transferase activity|regulation of metabolic process|regulation of cell death|defense response|transferase activity, transferring phosphorus-containing groups|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|response to bacterium|cell communication|signal transduction|negative regulation of signal transduction|cell death|integral component of membrane|response to organic substance|regulation of gene expression|cell surface receptor signaling pathway|response to lipid|response to cytokine|response to molecule of bacterial origin|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|positive regulation of gene expression|phosphotransferase activity, for other substituted phosphate groups|cellular response to molecule of bacterial origin|inflammatory response|programmed cell death|gene expression|cellular response to organic substance|response to lipopolysaccharide|regulation of programmed cell death|apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|regulation of extrinsic apoptotic signaling pathway|sphingomyelin synthase activity|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|response to tumor necrosis factor|cellular response to lipid|extrinsic apoptotic signaling pathway|apoptotic process|cellular response to lipopolysaccharide|cellular response to tumor necrosis factor K04714 shingomyelin synthase[2.7.8.27] hsa01100|hsa04071|hsa00600 Metabolic pathways - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human) 10:50305586-50625163 196 240 484 711 857 1073 1.39889425358988 1.55675032781522 3.11449663870089 4.54669351482962 5.01853305828723 7.17723341919005 2.023380406702 5.58081999743563 -1.46370953472471 5.84124177164423e-07 7.61171679837045e-06 DOWN ENSG00000204779 FOXD4L5 forkhead box D4-like 5 [Source:HGNC Symbol;Acc:HGNC:18522] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 9:65282101-65285209 36 27 9 3 3 1 0.81908677646566 0.558310576002813 0.184615340557592 0.0611484395993829 0.0560088650383159 0.0213205999928331 0.520670897675355 0.0461593015435106 3.4956784719217 5.84754546996207e-07 7.61660656458323e-06 UP ENSG00000107262 BAG1 BCL2 associated athanogene 1 [Source:HGNC Symbol;Acc:HGNC:937] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0005057|GO:0009628|GO:0006457|GO:0043227|GO:0005622|GO:0005515|GO:0010941|GO:0061077|GO:0033554|GO:0043231|GO:0042026|GO:0051087|GO:0005737|GO:0009408|GO:0060548|GO:0007154|GO:0007165|GO:0008219|GO:0009266|GO:1900034|GO:0005829|GO:0007166|GO:0043069|GO:0070389|GO:0034605|GO:0012501|GO:0035556|GO:0005634|GO:0043067|GO:0042981|GO:0043066|GO:0006915 signal transducer activity|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|receptor signaling protein activity|response to abiotic stimulus|protein folding|membrane-bounded organelle|intracellular|protein binding|regulation of cell death|chaperone-mediated protein folding|cellular response to stress|intracellular membrane-bounded organelle|protein refolding|chaperone binding|cytoplasm|response to heat|negative regulation of cell death|cell communication|signal transduction|cell death|response to temperature stimulus|regulation of cellular response to heat|cytosol|cell surface receptor signaling pathway|negative regulation of programmed cell death|chaperone cofactor-dependent protein refolding|cellular response to heat|programmed cell death|intracellular signal transduction|nucleus|regulation of programmed cell death|regulation of apoptotic process|negative regulation of apoptotic process|apoptotic process K09555 BCL2-associated athanogene 1[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 9:33247820-33264761 1646 1717 1191 797 827 559 8.07776314766819 7.65793324497375 5.26971630717709 3.5044290547404 3.32992506526227 2.57099942914326 7.00180423327301 3.13511784971531 1.15920705009775 5.87474685495007e-07 7.64536585037836e-06 UP ENSG00000168461 RAB31 RAB31, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9771] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0012505|GO:0031090|GO:0006810|GO:0031623|GO:0043168|GO:0032940|GO:0001882|GO:0031982|GO:0016817|GO:0043231|GO:0010243|GO:0005737|GO:0012506|GO:0030666|GO:0045184|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0051649|GO:0009725|GO:0000166|GO:0010033|GO:0010256|GO:0005794|GO:0005768|GO:0006996|GO:0016192|GO:0090150|GO:0005802|GO:0035639|GO:0031410|GO:0005769|GO:0001883|GO:0015031|GO:1901652|GO:0071417|GO:0007009|GO:0016023|GO:0006887|GO:0016818|GO:0046907|GO:0032549|GO:0090382|GO:0005770|GO:0072657|GO:0043434|GO:0031988|GO:0034613|GO:0035556|GO:0030659|GO:0046903|GO:0071310|GO:0000139|GO:0017076|GO:0019003|GO:0032870|GO:0030670|GO:0043112|GO:0032561|GO:0045055|GO:0030139|GO:0051169|GO:1901653|GO:0072659|GO:0090002|GO:0048193|GO:0006886|GO:0071375|GO:0032868|GO:0005525|GO:0006897|GO:0007264|GO:0019001|GO:1990778|GO:0016462|GO:0032588|GO:0043001|GO:0006913|GO:0017111|GO:0045335|GO:0032869|GO:0006898|GO:0006892|GO:0003924|GO:0006893 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|endomembrane system|organelle membrane|transport|receptor internalization|anion binding|secretion by cell|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|vesicle membrane|endocytic vesicle membrane|establishment of protein localization|protein localization|cell communication|membrane organization|signal transduction|establishment of localization in cell|response to hormone|nucleotide binding|response to organic substance|endomembrane system organization|Golgi apparatus|endosome|organelle organization|vesicle-mediated transport|establishment of protein localization to membrane|trans-Golgi network|purine ribonucleoside triphosphate binding|cytoplasmic vesicle|early endosome|purine nucleoside binding|protein transport|response to peptide|cellular response to organonitrogen compound|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|exocytosis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|phagosome maturation|late endosome|protein localization to membrane|response to peptide hormone|membrane-bounded vesicle|cellular protein localization|intracellular signal transduction|cytoplasmic vesicle membrane|secretion|cellular response to organic substance|Golgi membrane|purine nucleotide binding|GDP binding|cellular response to hormone stimulus|phagocytic vesicle membrane|receptor metabolic process|guanyl ribonucleotide binding|regulated exocytosis|endocytic vesicle|nuclear transport|cellular response to peptide|protein localization to plasma membrane|establishment of protein localization to plasma membrane|Golgi vesicle transport|intracellular protein transport|cellular response to peptide hormone stimulus|response to insulin|GTP binding|endocytosis|small GTPase mediated signal transduction|guanyl nucleotide binding|protein localization to cell periphery|pyrophosphatase activity|trans-Golgi network membrane|Golgi to plasma membrane protein transport|nucleocytoplasmic transport|nucleoside-triphosphatase activity|phagocytic vesicle|cellular response to insulin stimulus|receptor-mediated endocytosis|post-Golgi vesicle-mediated transport|GTPase activity|Golgi to plasma membrane transport K07891 Ras-related protein Rab-22[-] hsa04144 Endocytosis - Homo sapiens (human) 18:9708165-9862551 237 245 351 555 699 745 2.11594300386564 1.98793631629811 2.82538544614914 4.43962981318572 5.12037126788255 6.23363445417586 2.3097549221043 5.26454517841471 -1.18856911564528 5.9084917457446e-07 7.68593083126184e-06 DOWN ENSG00000236085 ACTG1P4 actin gamma 1 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:149] - - - - - - 1:103569553-103570674 10 16 12 1 1 1 0.630423912193985 0.91675297082452 0.682118203173407 0.0564606002681034 0.0517497572053052 0.0590782044364689 0.743098362063971 0.0557628539699592 3.7361768832815 5.91547891326451e-07 7.69166844410273e-06 UP ENSG00000203666 EFCAB2 EF-hand calcium binding domain 2 [Source:HGNC Symbol;Acc:HGNC:28166] GO:0005488|GO:0043167|GO:0043169|GO:0046872|GO:0005509 binding|ion binding|cation binding|metal ion binding|calcium ion binding - - - - 1:244969705-245127164 60 51 51 208 222 123 0.313851405733683 0.242452327936879 0.240522112645255 0.97484053203707 0.952780956461484 0.60298783056388 0.265608615438606 0.843536439687478 -1.66714844887023 5.9196990454115e-07 7.69380475845515e-06 DOWN ENSG00000088325 TPX2 TPX2, microtubule-associated [Source:HGNC Symbol;Acc:HGNC:1249] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0042995|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0044297|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0043025|GO:0022402|GO:0043168|GO:0005874|GO:0001882|GO:0031325|GO:0051128|GO:0022607|GO:0061676|GO:0043231|GO:0019899|GO:0005737|GO:0032886|GO:0043005|GO:0036477|GO:0043085|GO:0008219|GO:0050790|GO:0000166|GO:0051301|GO:0007017|GO:0019538|GO:0031323|GO:0006996|GO:0032268|GO:0035639|GO:1903047|GO:0030424|GO:0043412|GO:0007010|GO:0070507|GO:0001883|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0031981|GO:0007346|GO:0010564|GO:0051247|GO:0005654|GO:0007051|GO:0006461|GO:0070925|GO:0019900|GO:0032270|GO:0012501|GO:0006796|GO:0033043|GO:0044267|GO:0051174|GO:0007067|GO:0017076|GO:0051246|GO:0000226|GO:0043203|GO:0005856|GO:0000922|GO:0005634|GO:0005819|GO:0051225|GO:0032561|GO:0031401|GO:0005524|GO:0060236|GO:0030554|GO:0016310|GO:0007052|GO:0051493|GO:0015630|GO:0005525|GO:0019901|GO:0006464|GO:0090307|GO:0019001|GO:0043549|GO:0006915|GO:0033674|GO:0045859|GO:0045860|GO:0006468|GO:0042325|GO:0001932|GO:0001934|GO:0042327|GO:0032147 cell|cellular process|metabolic process|binding|small molecule binding|cell projection|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cell body|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|neuronal cell body|cell cycle process|anion binding|microtubule|nucleoside binding|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|importin-alpha family protein binding|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of microtubule-based process|neuron projection|somatodendritic compartment|positive regulation of catalytic activity|cell death|regulation of catalytic activity|nucleotide binding|cell division|microtubule-based process|protein metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|purine ribonucleoside triphosphate binding|mitotic cell cycle process|axon|macromolecule modification|cytoskeleton organization|regulation of microtubule cytoskeleton organization|purine nucleoside binding|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|nucleoplasm|spindle organization|protein complex assembly|organelle assembly|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|purine nucleotide binding|regulation of protein metabolic process|microtubule cytoskeleton organization|axon hillock|cytoskeleton|spindle pole|nucleus|spindle|spindle assembly|guanyl ribonucleotide binding|positive regulation of protein modification process|ATP binding|regulation of mitotic spindle organization|adenyl nucleotide binding|phosphorylation|mitotic spindle organization|regulation of cytoskeleton organization|microtubule cytoskeleton|GTP binding|protein kinase binding|cellular protein modification process|mitotic spindle assembly|guanyl nucleotide binding|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|activation of protein kinase activity - - - - 20:31739271-31801805 1497 1493 2173 4062 4233 3286 29.3739473437159 26.6244366511346 38.4427561586501 71.4131393426731 68.1485633572152 60.4278279640326 31.4803800511669 66.6631768879736 -1.0824371138108 5.92537487943952e-07 7.69783035904209e-06 DOWN ENSG00000140044 JDP2 Jun dimerization protein 2 [Source:HGNC Symbol;Acc:HGNC:17546] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0019222|GO:0045595|GO:0006725|GO:0051130|GO:1901360|GO:0016570|GO:0003676|GO:0045596|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0000981|GO:0046983|GO:0009890|GO:0003682|GO:0006139|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0000982|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0043412|GO:0010629|GO:0031056|GO:0046982|GO:0051252|GO:0006325|GO:0031058|GO:0036211|GO:0045599|GO:0051247|GO:0032270|GO:0033043|GO:0044267|GO:0010467|GO:0001227|GO:0045598|GO:0051246|GO:0009059|GO:0030154|GO:0016070|GO:0016575|GO:0005634|GO:0010638|GO:2001252|GO:0031063|GO:0000975|GO:0045444|GO:0031401|GO:0001078|GO:0045892|GO:0032774|GO:0031065|GO:0043565|GO:2001141|GO:0033044|GO:1902679|GO:0003690|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0090312|GO:0006357|GO:1903506|GO:0044212|GO:0090311|GO:0000122|GO:0000976|GO:0001012|GO:0006476|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|histone modification|nucleic acid binding|negative regulation of cell differentiation|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|protein dimerization activity|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|negative regulation of gene expression|regulation of histone modification|protein heterodimerization activity|regulation of RNA metabolic process|chromatin organization|positive regulation of histone modification|protein modification process|negative regulation of fat cell differentiation|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|regulation of organelle organization|cellular protein metabolic process|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of fat cell differentiation|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|histone deacetylation|nucleus|positive regulation of organelle organization|positive regulation of chromosome organization|regulation of histone deacetylation|regulatory region DNA binding|fat cell differentiation|positive regulation of protein modification process|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|positive regulation of histone deacetylation|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of chromosome organization|negative regulation of RNA biosynthetic process|double-stranded DNA binding|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|positive regulation of protein deacetylation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of protein deacetylation|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|protein deacetylation|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 14:75427716-75474111 156 176 492 897 932 861 0.940987968577209 0.964830320279375 2.6757056879115 4.84784968884415 4.61256615727341 4.86733345943176 1.52717465892269 4.77591643518311 -1.64491252502199 5.98046139866702e-07 7.76601542391497e-06 DOWN ENSG00000164091 WDR82 WD repeat domain 82 [Source:HGNC Symbol;Acc:HGNC:28826] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0044877|GO:0043229|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0008287|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0072357|GO:0016570|GO:0043231|GO:0003682|GO:0019538|GO:0006996|GO:0051276|GO:0008168|GO:0043412|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0005694|GO:0044267|GO:0035097|GO:0005634|GO:0048188|GO:0000781|GO:0018022|GO:0008276|GO:0034968|GO:0016568|GO:0006464|GO:0008757|GO:0008170|GO:0016279|GO:0051568|GO:0018193|GO:0042054|GO:0018024|GO:0018205|GO:0042800 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|methylation|macromolecular complex binding|intracellular organelle|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|protein serine/threonine phosphatase complex|intracellular|protein binding|protein complex|transferase activity|PTW/PP1 phosphatase complex|histone modification|intracellular membrane-bounded organelle|chromatin binding|protein metabolic process|organelle organization|chromosome organization|methyltransferase activity|macromolecule modification|histone methylation|protein methylation|chromatin organization|protein modification process|nuclear lumen|transferase complex|nucleoplasm|chromosome|cellular protein metabolic process|histone methyltransferase complex|nucleus|Set1C/COMPASS complex|chromosome, telomeric region|peptidyl-lysine methylation|protein methyltransferase activity|histone lysine methylation|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|N-methyltransferase activity|protein-lysine N-methyltransferase activity|histone H3-K4 methylation|peptidyl-amino acid modification|histone methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine modification|histone methyltransferase activity (H3-K4 specific) K14962 COMPASS component SWD2[-] hsa03015 mRNA surveillance pathway - Homo sapiens (human) 3:52254421-52288020 3260 3465 2514 1731 1654 1290 26.9583995189081 26.0411240970185 18.7437320927994 12.8254113941125 11.2222513330289 9.99758359636631 23.9144185695753 11.3484154411692 1.07538984489106 5.99790439467395e-07 7.78527990428679e-06 UP ENSG00000154945 ANKRD40 ankyrin repeat domain 40 [Source:HGNC Symbol;Acc:HGNC:28233] GO:0005488|GO:0005515 binding|protein binding - - - - 17:50693190-50707924 461 596 739 1295 1381 1283 5.82419421154747 6.84323859411344 8.41770773013523 14.6589417723927 14.3151875498081 15.1911518751425 7.02838017859871 14.7217603991144 -1.06668605962333 6.00825754380714e-07 7.79532901837542e-06 DOWN ENSG00000171843 MLLT3 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 [Source:HGNC Symbol;Acc:HGNC:7136] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0043227|GO:0023057|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0008023|GO:0006725|GO:0009888|GO:0007164|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0007389|GO:0009887|GO:0009966|GO:0048729|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0009967|GO:0044249|GO:0031323|GO:0030111|GO:0010468|GO:0034645|GO:0030178|GO:0007166|GO:0002009|GO:0051252|GO:0001736|GO:2000027|GO:0003002|GO:0031981|GO:0005654|GO:0060429|GO:0007379|GO:0010467|GO:0030177|GO:0009059|GO:0016070|GO:0005634|GO:0016055|GO:0090090|GO:0060828|GO:0032774|GO:2001141|GO:2000052|GO:0090175|GO:0009952|GO:0006351|GO:0035282|GO:0006355|GO:0001738|GO:0035567|GO:1903506|GO:0060070|GO:2000095|GO:2000096|GO:0060071 developmental process|macromolecular complex|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|transcription elongation factor complex|cellular aromatic compound metabolic process|tissue development|establishment of tissue polarity|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|pattern specification process|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|positive regulation of signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|regulation of Wnt signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|morphogenesis of an epithelium|regulation of RNA metabolic process|establishment of planar polarity|regulation of organ morphogenesis|regionalization|nuclear lumen|nucleoplasm|epithelium development|segment specification|gene expression|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|RNA metabolic process|nucleus|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of canonical Wnt signaling pathway|RNA biosynthetic process|regulation of RNA biosynthetic process|positive regulation of non-canonical Wnt signaling pathway|regulation of establishment of planar polarity|anterior/posterior pattern specification|transcription, DNA-templated|segmentation|regulation of transcription, DNA-templated|morphogenesis of a polarized epithelium|non-canonical Wnt signaling pathway|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|regulation of Wnt signaling pathway, planar cell polarity pathway|positive regulation of Wnt signaling pathway, planar cell polarity pathway|Wnt signaling pathway, planar cell polarity pathway K15187 YEATS domain-containing protein 1/3[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 9:20341665-20622543 137 131 310 550 517 707 0.733605512495568 0.637522104240422 1.49664361333469 2.63878234715687 2.27144039366375 3.5480601720159 0.955923743356893 2.81942763761217 -1.5604348755564 6.02678969571344e-07 7.81597652371108e-06 DOWN ENSG00000129534 MIS18BP1 MIS18 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:20190] GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0022402|GO:0003676|GO:0000776|GO:0022607|GO:0043231|GO:0051301|GO:0006996|GO:0051276|GO:0003677|GO:1903047|GO:0006325|GO:0000278|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0007067|GO:0005634|GO:0000777|GO:0006334|GO:0034622|GO:0000793|GO:0034728|GO:0034508|GO:0000794|GO:0000780|GO:0006333|GO:0065004|GO:0031497|GO:0000778|GO:0016568|GO:0071103|GO:0000775|GO:0006336|GO:0006323|GO:0043486|GO:0000779|GO:0006338|GO:0034080|GO:0043044 macromolecular complex|cell|cellular process|binding|organic cyclic compound binding|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|cell cycle process|nucleic acid binding|kinetochore|cellular component assembly|intracellular membrane-bounded organelle|cell division|organelle organization|chromosome organization|DNA binding|mitotic cell cycle process|chromatin organization|mitotic cell cycle|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|mitotic nuclear division|nucleus|condensed chromosome kinetochore|nucleosome assembly|cellular macromolecular complex assembly|condensed chromosome|nucleosome organization|centromere complex assembly|condensed nuclear chromosome|condensed nuclear chromosome, centromeric region|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|condensed nuclear chromosome kinetochore|chromatin modification|DNA conformation change|chromosome, centromeric region|DNA replication-independent nucleosome assembly|DNA packaging|histone exchange|condensed chromosome, centromeric region|chromatin remodeling|CENP-A containing nucleosome assembly|ATP-dependent chromatin remodeling - - - - 14:45203190-45253540 627 775 1058 1726 2101 1699 4.39869395897945 4.94126255928319 6.69200074931327 10.8491156147077 12.0934427464634 11.1706491385078 5.34398575585864 11.3710691665596 -1.0893798427407 6.0645337343481e-07 7.85779046726846e-06 DOWN ENSG00000167716 WDR81 WD repeat domain 81 [Source:HGNC Symbol;Acc:HGNC:26600] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0016043|GO:0043227|GO:0071944|GO:0032504|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0007049|GO:0051640|GO:0048468|GO:0006810|GO:0022402|GO:0005938|GO:0007275|GO:0005874|GO:0000776|GO:0043231|GO:0005737|GO:0045502|GO:0006928|GO:0032403|GO:0051656|GO:0005875|GO:0007163|GO:0044092|GO:0010970|GO:0007276|GO:0051649|GO:0008092|GO:0050790|GO:0043086|GO:0048869|GO:0007017|GO:0019538|GO:0031324|GO:0007281|GO:0031323|GO:0006996|GO:0031023|GO:0051650|GO:0015631|GO:0032268|GO:0051653|GO:0005813|GO:1903047|GO:0043412|GO:0007010|GO:0005815|GO:0008017|GO:0036211|GO:0032269|GO:0000278|GO:0046907|GO:0008088|GO:0030010|GO:0007018|GO:0051346|GO:0005739|GO:0051647|GO:0005694|GO:0051293|GO:0006796|GO:0044267|GO:0051174|GO:0007399|GO:0051648|GO:0051246|GO:0030154|GO:0000226|GO:0072384|GO:0005856|GO:0040023|GO:0010923|GO:0016311|GO:0047496|GO:0008090|GO:0051294|GO:0015630|GO:0040001|GO:0000132|GO:0007097|GO:2000574|GO:0022008|GO:0006464|GO:0030705|GO:0010921|GO:0000775|GO:0006470|GO:0035304|GO:0035305|GO:0035303|GO:0035308 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|cell periphery|multicellular organism reproduction|intracellular|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|cell cycle|organelle localization|cell development|transport|cell cycle process|cell cortex|multicellular organism development|microtubule|kinetochore|intracellular membrane-bounded organelle|cytoplasm|dynein binding|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|microtubule associated complex|establishment or maintenance of cell polarity|negative regulation of molecular function|establishment of localization by movement along microtubule|gamete generation|establishment of localization in cell|cytoskeletal protein binding|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|microtubule-based process|protein metabolic process|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|organelle organization|microtubule organizing center organization|establishment of vesicle localization|tubulin binding|regulation of cellular protein metabolic process|spindle localization|centrosome|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|microtubule organizing center|microtubule binding|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|intracellular transport|axo-dendritic transport|establishment of cell polarity|microtubule-based movement|negative regulation of hydrolase activity|mitochondrion|nucleus localization|chromosome|establishment of spindle localization|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|vesicle localization|regulation of protein metabolic process|cell differentiation|microtubule cytoskeleton organization|organelle transport along microtubule|cytoskeleton|establishment of nucleus localization|negative regulation of phosphatase activity|dephosphorylation|vesicle transport along microtubule|retrograde axonal transport|establishment of spindle orientation|microtubule cytoskeleton|establishment of mitotic spindle localization|establishment of mitotic spindle orientation|nuclear migration|regulation of microtubule motor activity|neurogenesis|cellular protein modification process|cytoskeleton-dependent intracellular transport|regulation of phosphatase activity|chromosome, centromeric region|protein dephosphorylation|regulation of protein dephosphorylation|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation - - - - 17:1716523-1738599 965 1120 675 481 410 416 3.97814765662637 4.19615945143594 2.50883406666734 1.77662638576775 1.38677287900363 1.60722218065741 3.56104705824322 1.59020714847626 1.16308679008972 6.0669280589046e-07 7.85779046726846e-06 UP ENSG00000237493 RP11-603J24.7 - - - - - - - 12:55980432-55981035 352 409 440 213 195 205 41.224073830936 43.5323459850948 46.4596169646736 22.3503985408368 18.7374953404608 22.5004473583474 43.7386789269015 21.1961137465483 1.04510987163705 6.09251354372476e-07 7.88750647590455e-06 UP ENSG00000066136 NFYC nuclear transcription factor Y subunit gamma [Source:HGNC Symbol;Acc:HGNC:7806] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0006457|GO:0043227|GO:0009893|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0044281|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0005667|GO:0046983|GO:0006139|GO:0008134|GO:0044249|GO:0031323|GO:0003713|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0044798|GO:0046982|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0010467|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0003690|GO:0090575|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0016602|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|protein folding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor complex|protein dimerization activity|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|regulation of cellular metabolic process|transcription coactivator activity|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|nuclear transcription factor complex|protein heterodimerization activity|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|RNA polymerase II transcription factor complex|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|CCAAT-binding factor complex|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K08066 nuclear transcription factor Y, gamma[-] hsa05152|hsa04612 Tuberculosis - Homo sapiens (human)|Antigen processing and presentation - Homo sapiens (human) 1:40691570-40771603 222 221 201 577 702 431 0.977867852601689 0.884707901122873 0.798249460349187 2.27719669026768 2.53706799897183 1.77923610511657 0.886941738024583 2.19783359811869 -1.30917091730997 6.11038845355935e-07 7.90721876430693e-06 DOWN ENSG00000103647 CORO2B coronin, actin binding protein, 2B [Source:HGNC Symbol;Acc:HGNC:2256] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0044877|GO:0043229|GO:0016043|GO:0005622|GO:0005515|GO:0005737|GO:0032403|GO:0008092|GO:0030029|GO:0006996|GO:0007010|GO:0003779|GO:0030036|GO:0051015|GO:0005856|GO:0015629 cell|membrane|cellular process|binding|macromolecular complex binding|intracellular organelle|cellular component organization|intracellular|protein binding|cytoplasm|protein complex binding|cytoskeletal protein binding|actin filament-based process|organelle organization|cytoskeleton organization|actin binding|actin cytoskeleton organization|actin filament binding|cytoskeleton|actin cytoskeleton - - - - 15:68578969-68727806 6 2 6 26 26 35 0.0712202345509297 0.0215765403856585 0.0642168672562982 0.276529291754599 0.253231176767058 0.389374585538134 0.0523378807309621 0.306378351353264 -2.54938694728143 6.11450994220337e-07 7.90912390877554e-06 DOWN ENSG00000153107 ANAPC1 anaphase promoting complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:19988] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0051726|GO:0007049|GO:0022402|GO:0051302|GO:0031325|GO:0051128|GO:0045786|GO:0043231|GO:0005737|GO:0051782|GO:0043085|GO:0044092|GO:0051983|GO:0050790|GO:0007059|GO:0051301|GO:0043086|GO:0000151|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0005829|GO:0045732|GO:0000819|GO:0000075|GO:1903047|GO:0043412|GO:0030163|GO:0051304|GO:0031461|GO:0044770|GO:0044265|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0031981|GO:0051351|GO:0007346|GO:1990234|GO:0010564|GO:0051247|GO:0045930|GO:0006508|GO:0005654|GO:0032270|GO:0033043|GO:0044267|GO:0042176|GO:0007067|GO:0051246|GO:0042177|GO:0005634|GO:0000152|GO:0010948|GO:0044257|GO:0031577|GO:0031401|GO:2001251|GO:0010498|GO:0051436|GO:0007093|GO:0007088|GO:1903364|GO:1903363|GO:0044772|GO:0030162|GO:0005680|GO:0051444|GO:0007094|GO:0045862|GO:0051439|GO:0071174|GO:0033044|GO:1901990|GO:0051603|GO:0045839|GO:0000070|GO:0051306|GO:0045861|GO:1901987|GO:0051438|GO:0007091|GO:0051443|GO:0006464|GO:1901991|GO:0030071|GO:0071173|GO:1903052|GO:0010965|GO:0019941|GO:1901799|GO:2000816|GO:1903051|GO:0061136|GO:0051437|GO:0043161|GO:0032446|GO:0006511|GO:0031398|GO:2000058|GO:0031396|GO:0032434|GO:0032435|GO:0031397|GO:2000060|GO:0031145|GO:0042787|GO:0016567|GO:0000209|GO:0070979 macromolecular complex|cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell cycle|cell cycle|cell cycle process|regulation of cell division|positive regulation of cellular metabolic process|regulation of cellular component organization|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|negative regulation of cell division|positive regulation of catalytic activity|negative regulation of molecular function|regulation of chromosome segregation|regulation of catalytic activity|chromosome segregation|cell division|negative regulation of catalytic activity|ubiquitin ligase complex|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|cytosol|positive regulation of protein catabolic process|sister chromatid segregation|cell cycle checkpoint|mitotic cell cycle process|macromolecule modification|protein catabolic process|chromosome separation|cullin-RING ubiquitin ligase complex|cell cycle phase transition|cellular macromolecule catabolic process|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|nuclear lumen|positive regulation of ligase activity|regulation of mitotic cell cycle|transferase complex|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|proteolysis|nucleoplasm|positive regulation of cellular protein metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of protein catabolic process|mitotic nuclear division|regulation of protein metabolic process|negative regulation of protein catabolic process|nucleus|nuclear ubiquitin ligase complex|negative regulation of cell cycle process|cellular protein catabolic process|spindle checkpoint|positive regulation of protein modification process|negative regulation of chromosome organization|proteasomal protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|mitotic cell cycle checkpoint|regulation of mitotic nuclear division|positive regulation of cellular protein catabolic process|negative regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of proteolysis|anaphase-promoting complex|negative regulation of ubiquitin-protein transferase activity|mitotic spindle assembly checkpoint|positive regulation of proteolysis|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|mitotic spindle checkpoint|regulation of chromosome organization|regulation of mitotic cell cycle phase transition|proteolysis involved in cellular protein catabolic process|negative regulation of mitotic nuclear division|mitotic sister chromatid segregation|mitotic sister chromatid separation|negative regulation of proteolysis|regulation of cell cycle phase transition|regulation of ubiquitin-protein transferase activity|metaphase/anaphase transition of mitotic cell cycle|positive regulation of ubiquitin-protein transferase activity|cellular protein modification process|negative regulation of mitotic cell cycle phase transition|regulation of mitotic metaphase/anaphase transition|spindle assembly checkpoint|positive regulation of proteolysis involved in cellular protein catabolic process|regulation of mitotic sister chromatid separation|modification-dependent protein catabolic process|negative regulation of proteasomal protein catabolic process|negative regulation of mitotic sister chromatid separation|negative regulation of proteolysis involved in cellular protein catabolic process|regulation of proteasomal protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination|protein K11-linked ubiquitination K03348 anaphase-promoting complex subunit 1[-] hsa05166|hsa04120|hsa04110|hsa04114|hsa04914 HTLV-I infection - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human) 2:111766271-111884690 527 666 741 1405 1714 1225 2.36748022283937 2.71912892378865 3.00128932332151 5.65522141596232 6.31763116999355 5.15751702124431 2.69596615664984 5.71012320240006 -1.08271948770173 6.12778094782505e-07 7.92089998044542e-06 DOWN ENSG00000158055 GRHL3 grainyhead-like transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:25839] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0090102|GO:0035239|GO:0006725|GO:0009888|GO:0007164|GO:0035295|GO:1901360|GO:0048839|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0005737|GO:0000981|GO:0007389|GO:0032970|GO:0009611|GO:0007423|GO:0009887|GO:0042592|GO:0021915|GO:0048729|GO:0048598|GO:0048568|GO:0003682|GO:0048871|GO:0006139|GO:0043085|GO:0007154|GO:0035148|GO:0061029|GO:0007165|GO:0050790|GO:0030029|GO:0044249|GO:0031323|GO:0050878|GO:0006996|GO:0003677|GO:0010468|GO:0034645|GO:0007166|GO:0001654|GO:0032956|GO:0002009|GO:0007010|GO:0007417|GO:0051345|GO:0050891|GO:0043583|GO:0048878|GO:0051252|GO:0007398|GO:0090103|GO:0009790|GO:0001736|GO:0010628|GO:0072175|GO:0042060|GO:2000027|GO:0042472|GO:0031981|GO:0016331|GO:0005654|GO:0043588|GO:0030036|GO:0001841|GO:0060429|GO:0033043|GO:0010467|GO:0090177|GO:0048562|GO:0007399|GO:0060562|GO:0031328|GO:0009059|GO:0060606|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0051960|GO:0045995|GO:0031490|GO:0016055|GO:0045893|GO:0009792|GO:0043566|GO:0001843|GO:0043010|GO:0042249|GO:0032774|GO:0043565|GO:2001141|GO:0001838|GO:0043087|GO:0061436|GO:0008544|GO:0030104|GO:0090175|GO:0043547|GO:0042471|GO:0051493|GO:0090178|GO:0033561|GO:0006351|GO:0006355|GO:0001738|GO:0045944|GO:0006366|GO:0035567|GO:0006357|GO:1903506|GO:0090179|GO:0043009|GO:0060071 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|cochlea development|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|establishment of tissue polarity|tube development|organic cyclic compound metabolic process|inner ear development|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|regulation of actin filament-based process|response to wounding|sensory organ development|organ morphogenesis|homeostatic process|neural tube development|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|chromatin binding|multicellular organismal homeostasis|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|tube formation|eyelid development in camera-type eye|signal transduction|regulation of catalytic activity|actin filament-based process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of body fluid levels|organelle organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|eye development|regulation of actin cytoskeleton organization|morphogenesis of an epithelium|cytoskeleton organization|central nervous system development|positive regulation of hydrolase activity|multicellular organismal water homeostasis|ear development|chemical homeostasis|regulation of RNA metabolic process|ectoderm development|cochlea morphogenesis|embryo development|establishment of planar polarity|positive regulation of gene expression|epithelial tube formation|wound healing|regulation of organ morphogenesis|inner ear morphogenesis|nuclear lumen|morphogenesis of embryonic epithelium|nucleoplasm|skin development|actin cytoskeleton organization|neural tube formation|epithelium development|regulation of organelle organization|gene expression|establishment of planar polarity involved in neural tube closure|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|tube closure|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of nervous system development|regulation of embryonic development|chromatin DNA binding|Wnt signaling pathway|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|structure-specific DNA binding|neural tube closure|camera-type eye development|establishment of planar polarity of embryonic epithelium|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|embryonic epithelial tube formation|regulation of GTPase activity|establishment of skin barrier|epidermis development|water homeostasis|regulation of establishment of planar polarity|positive regulation of GTPase activity|ear morphogenesis|regulation of cytoskeleton organization|regulation of establishment of planar polarity involved in neural tube closure|regulation of water loss via skin|transcription, DNA-templated|regulation of transcription, DNA-templated|morphogenesis of a polarized epithelium|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|non-canonical Wnt signaling pathway|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|planar cell polarity pathway involved in neural tube closure|chordate embryonic development|Wnt signaling pathway, planar cell polarity pathway - - - - 1:24319322-24364482 358 372 527 207 164 219 4.89254409438239 4.62035108630788 6.49345678120026 2.5346637792188 1.83891860665756 2.80494815943406 5.33545065396351 2.39284351510347 1.15688408014648 6.12892039754436e-07 7.92089998044542e-06 UP ENSG00000196586 MYO6 myosin VI [Source:HGNC Symbol;Acc:HGNC:7605] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0045177|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0031252|GO:0016787|GO:0009058|GO:0005905|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0005884|GO:0005938|GO:0034641|GO:0043168|GO:0001882|GO:0031982|GO:0031325|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0005774|GO:0005737|GO:0007267|GO:0012506|GO:0001726|GO:0005635|GO:0006928|GO:0032403|GO:0045184|GO:0016459|GO:0042493|GO:0006139|GO:0008104|GO:0005516|GO:0007154|GO:0061024|GO:0007165|GO:0070062|GO:0051649|GO:0008092|GO:0031941|GO:0031256|GO:0031965|GO:0000166|GO:0031253|GO:0030029|GO:0044249|GO:0031323|GO:0005794|GO:0016192|GO:0005829|GO:0010468|GO:0034645|GO:0016461|GO:0035639|GO:0031410|GO:0051252|GO:0030048|GO:0001883|GO:0003779|GO:0015031|GO:0005773|GO:0010628|GO:0016023|GO:0016818|GO:0030665|GO:0046907|GO:0032549|GO:0043531|GO:0051046|GO:0031981|GO:1990234|GO:0048471|GO:0031988|GO:0005654|GO:0034613|GO:0032587|GO:0051015|GO:0035556|GO:0030659|GO:0010467|GO:0046903|GO:0017076|GO:0005902|GO:0031328|GO:0009059|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0006974|GO:0015629|GO:0045893|GO:0030139|GO:0000323|GO:0072331|GO:0042770|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0006886|GO:0030135|GO:0006897|GO:0016591|GO:0016462|GO:0006351|GO:0005765|GO:0006355|GO:0030136|GO:0045944|GO:0006366|GO:0006357|GO:0005764|GO:1903506|GO:0017111|GO:0045334|GO:0030330|GO:0007268|GO:0003774|GO:0000146|GO:0060001 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|apical part of cell|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|cell leading edge|hydrolase activity|biosynthetic process|coated pit|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|actin filament|cell cortex|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|cell-cell signaling|vesicle membrane|ruffle|nuclear envelope|movement of cell or subcellular component|protein complex binding|establishment of protein localization|myosin complex|response to drug|nucleobase-containing compound metabolic process|protein localization|calmodulin binding|cell communication|membrane organization|signal transduction|extracellular exosome|establishment of localization in cell|cytoskeletal protein binding|filamentous actin|leading edge membrane|nuclear membrane|nucleotide binding|cell projection membrane|actin filament-based process|cellular biosynthetic process|regulation of cellular metabolic process|Golgi apparatus|vesicle-mediated transport|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|unconventional myosin complex|purine ribonucleoside triphosphate binding|cytoplasmic vesicle|regulation of RNA metabolic process|actin filament-based movement|purine nucleoside binding|actin binding|protein transport|vacuole|positive regulation of gene expression|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|clathrin-coated vesicle membrane|intracellular transport|ribonucleoside binding|ADP binding|regulation of secretion|nuclear lumen|transferase complex|perinuclear region of cytoplasm|membrane-bounded vesicle|nucleoplasm|cellular protein localization|ruffle membrane|actin filament binding|intracellular signal transduction|cytoplasmic vesicle membrane|gene expression|secretion|purine nucleotide binding|microvillus|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|actin cytoskeleton|positive regulation of transcription, DNA-templated|endocytic vesicle|lytic vacuole|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|intracellular protein transport|coated vesicle|endocytosis|DNA-directed RNA polymerase II, holoenzyme|pyrophosphatase activity|transcription, DNA-templated|lysosomal membrane|regulation of transcription, DNA-templated|clathrin-coated vesicle|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|lysosome|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|clathrin-coated endocytic vesicle|DNA damage response, signal transduction by p53 class mediator|synaptic transmission|motor activity|microfilament motor activity|minus-end directed microfilament motor activity - - - - 6:75749192-75919537 402 484 900 1326 1502 2138 1.65847530176953 1.81471568036775 3.34764833391228 4.90144578066796 5.08417737067471 8.26645828990217 2.27361310534985 6.08402714708161 -1.42003981485192 6.1542130376257e-07 7.95014608504014e-06 DOWN ENSG00000240682 ISY1 ISY1 splicing factor homolog [Source:HGNC Symbol;Acc:HGNC:29201] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0000384|GO:0005515|GO:0043234|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0022607|GO:0043231|GO:0030529|GO:0006139|GO:0000974|GO:0022613|GO:0003723|GO:0022618|GO:0031981|GO:0005681|GO:0005654|GO:0006259|GO:0010467|GO:0006289|GO:0016070|GO:0005634|GO:0006974|GO:0071020|GO:0071012|GO:0034622|GO:0006396|GO:0071014|GO:0006283|GO:0006376|GO:0016071|GO:0044822|GO:0000350|GO:0000245|GO:0071013|GO:0000389|GO:0006397|GO:0008380|GO:0000375|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|first spliceosomal transesterification activity|protein binding|protein complex|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|Prp19 complex|ribonucleoprotein complex biogenesis|RNA binding|ribonucleoprotein complex assembly|nuclear lumen|spliceosomal complex|nucleoplasm|DNA metabolic process|gene expression|nucleotide-excision repair|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|post-spliceosomal complex|catalytic step 1 spliceosome|cellular macromolecular complex assembly|RNA processing|post-mRNA release spliceosomal complex|transcription-coupled nucleotide-excision repair|mRNA splice site selection|mRNA metabolic process|poly(A) RNA binding|generation of catalytic spliceosome for second transesterification step|spliceosomal complex assembly|catalytic step 2 spliceosome|mRNA 3'-splice site recognition|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome K12870 pre-mRNA-splicing factor ISY1[-] hsa03040 Spliceosome - Homo sapiens (human) 3:129127415-129161293 1475 1468 1654 878 896 509 16.1187819447377 14.5796201376032 16.2963326618355 8.59671391327847 8.03371189168725 5.21298863004521 15.6649115813921 7.28113814500364 1.10530073979315 6.20223967558452e-07 8.00525997729789e-06 UP ENSG00000078124 ACER3 alkaline ceramidase 3 [Source:HGNC Symbol;Acc:HGNC:16066] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0008284|GO:0042127|GO:0044255|GO:0031228|GO:0016798|GO:0034641|GO:0044281|GO:0043231|GO:0031227|GO:0005737|GO:0016810|GO:0030176|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0031301|GO:0005794|GO:0006665|GO:0006066|GO:0016811|GO:0006670|GO:0006643|GO:0030173|GO:0004553|GO:0043603|GO:0008610|GO:0000139|GO:0046512|GO:0006672|GO:0071602|GO:0017040|GO:0070774|GO:0030148|GO:0046520 cell|membrane|cellular process|metabolic process|catalytic activity|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|positive regulation of cell proliferation|regulation of cell proliferation|cellular lipid metabolic process|intrinsic component of Golgi membrane|hydrolase activity, acting on glycosyl bonds|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cytoplasm|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|integral component of endoplasmic reticulum membrane|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|integral component of organelle membrane|Golgi apparatus|sphingolipid metabolic process|alcohol metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|sphingosine metabolic process|membrane lipid metabolic process|integral component of Golgi membrane|hydrolase activity, hydrolyzing O-glycosyl compounds|cellular amide metabolic process|lipid biosynthetic process|Golgi membrane|sphingosine biosynthetic process|ceramide metabolic process|phytosphingosine biosynthetic process|ceramidase activity|phytoceramidase activity|sphingolipid biosynthetic process|sphingoid biosynthetic process K04711 dihydroceramidase [EC:3.5.1.-][-] hsa00600 Sphingolipid metabolism - Homo sapiens (human) 11:76860867-77026797 177 302 334 640 671 682 0.738623317791921 1.14534630569754 1.2566418134666 2.39292072361048 2.29742367053618 2.66725209158081 1.04687047898535 2.45253216190916 -1.22818909567108 6.20520283286081e-07 8.00562339551541e-06 DOWN ENSG00000166260 COX11 COX11 cytochrome c oxidase copper chaperone [Source:HGNC Symbol;Acc:HGNC:2261] GO:0009055|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0022857|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0004129|GO:0031224|GO:0005622|GO:0005515|GO:0031090|GO:0019222|GO:0044262|GO:0007585|GO:0019866|GO:0006810|GO:0044281|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0031966|GO:0022891|GO:0015002|GO:0044092|GO:0055085|GO:0050790|GO:0043086|GO:0016021|GO:0031324|GO:0031323|GO:0005740|GO:0006109|GO:0046872|GO:0006811|GO:0015075|GO:0005743|GO:0005996|GO:0005739|GO:0006461|GO:0006796|GO:0051174|GO:0034220|GO:0019318|GO:0098655|GO:0034622|GO:0015992|GO:0006812|GO:0043623|GO:0016310|GO:0010906|GO:0046914|GO:0033673|GO:0043549|GO:0008324|GO:0017004|GO:1902600|GO:0005507|GO:0033132|GO:0006006|GO:0042325|GO:0042326|GO:0022890|GO:0015672|GO:0008535|GO:0015077|GO:0015078 electron carrier activity|transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|transmembrane transporter activity|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|cytochrome-c oxidase activity|intrinsic component of membrane|intracellular|protein binding|organelle membrane|regulation of metabolic process|cellular carbohydrate metabolic process|respiratory gaseous exchange|organelle inner membrane|transport|small molecule metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|mitochondrial membrane|substrate-specific transmembrane transporter activity|heme-copper terminal oxidase activity|negative regulation of molecular function|transmembrane transport|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|mitochondrial envelope|regulation of carbohydrate metabolic process|metal ion binding|ion transport|ion transmembrane transporter activity|mitochondrial inner membrane|monosaccharide metabolic process|mitochondrion|protein complex assembly|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|ion transmembrane transport|hexose metabolic process|cation transmembrane transport|cellular macromolecular complex assembly|proton transport|cation transport|cellular protein complex assembly|phosphorylation|regulation of glucose metabolic process|transition metal ion binding|negative regulation of kinase activity|regulation of kinase activity|cation transmembrane transporter activity|cytochrome complex assembly|hydrogen ion transmembrane transport|copper ion binding|negative regulation of glucokinase activity|glucose metabolic process|regulation of phosphorylation|negative regulation of phosphorylation|inorganic cation transmembrane transporter activity|monovalent inorganic cation transport|respiratory chain complex IV assembly|monovalent inorganic cation transmembrane transporter activity|hydrogen ion transmembrane transporter activity K02258 cytochrome c oxidase assembly protein subunit 11[-] hsa01100|hsa00190 Metabolic pathways - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human) 17:54951902-54968785 1047 1074 828 415 441 597 6.42559889342331 5.99033691499535 4.58153959203976 2.2819875269802 2.22061776057627 3.43376072904961 5.66582513348614 2.64545533886869 1.09877001388702 6.22686208899881e-07 8.03009679503112e-06 UP ENSG00000091039 OSBPL8 oxysterol binding protein like 8 [Source:HGNC Symbol;Acc:HGNC:16396] GO:0040011|GO:0032502|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0040013|GO:0097159|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0072341|GO:0016043|GO:0010888|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0010883|GO:0006810|GO:0005938|GO:0005496|GO:0043168|GO:0005543|GO:0031325|GO:1900076|GO:0043231|GO:0043178|GO:0010243|GO:0005737|GO:0005635|GO:0006928|GO:0043177|GO:0009966|GO:0005319|GO:0010828|GO:0010646|GO:0043085|GO:0008104|GO:0001786|GO:0007154|GO:0061024|GO:0051270|GO:1900078|GO:0016477|GO:0007165|GO:0005783|GO:0009725|GO:0051271|GO:0019915|GO:0031965|GO:0050790|GO:0010891|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0010876|GO:0019538|GO:0010033|GO:0031323|GO:2000146|GO:0010256|GO:0006996|GO:1902533|GO:0032268|GO:0006998|GO:0046326|GO:0007166|GO:0005548|GO:0043412|GO:0046628|GO:0035091|GO:1901652|GO:0071417|GO:0030334|GO:0051347|GO:0036211|GO:0032934|GO:0006811|GO:0032541|GO:0072657|GO:0043434|GO:0006869|GO:0051247|GO:0030336|GO:0034613|GO:0032270|GO:0006796|GO:0035556|GO:0030730|GO:0044267|GO:0031406|GO:0051174|GO:0071782|GO:2001273|GO:0071310|GO:0006997|GO:0051246|GO:2001275|GO:0030154|GO:0046626|GO:1902531|GO:0008643|GO:0032870|GO:0005634|GO:0010827|GO:0015914|GO:0051896|GO:0043491|GO:0006820|GO:0015711|GO:0045444|GO:0033365|GO:0031401|GO:1901653|GO:0046324|GO:0016310|GO:0051897|GO:0090204|GO:0007167|GO:1901981|GO:0071375|GO:0016597|GO:0032868|GO:0015485|GO:0006464|GO:0090435|GO:0043549|GO:0033674|GO:0045859|GO:0008645|GO:0045860|GO:0006468|GO:0042325|GO:0001932|GO:0032869|GO:0070273|GO:0001934|GO:0042327|GO:0034504|GO:0007169|GO:0015758|GO:0032147|GO:0008286|GO:0046323|GO:0032148 locomotion|developmental process|transporter activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|negative regulation of locomotion|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell motility|regulation of signaling|modified amino acid binding|cellular component organization|negative regulation of lipid storage|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|regulation of lipid storage|transport|cell cortex|steroid binding|anion binding|phospholipid binding|positive regulation of cellular metabolic process|regulation of cellular response to insulin stimulus|intracellular membrane-bounded organelle|alcohol binding|response to organonitrogen compound|cytoplasm|nuclear envelope|movement of cell or subcellular component|organic acid binding|regulation of signal transduction|lipid transporter activity|positive regulation of glucose transport|regulation of cell communication|positive regulation of catalytic activity|protein localization|phosphatidylserine binding|cell communication|membrane organization|regulation of cellular component movement|positive regulation of cellular response to insulin stimulus|cell migration|signal transduction|endoplasmic reticulum|response to hormone|negative regulation of cellular component movement|lipid storage|nuclear membrane|regulation of catalytic activity|negative regulation of sequestering of triglyceride|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|lipid localization|protein metabolic process|response to organic substance|regulation of cellular metabolic process|negative regulation of cell motility|endomembrane system organization|organelle organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|nuclear envelope organization|positive regulation of glucose import|cell surface receptor signaling pathway|phospholipid transporter activity|macromolecule modification|positive regulation of insulin receptor signaling pathway|phosphatidylinositol binding|response to peptide|cellular response to organonitrogen compound|regulation of cell migration|positive regulation of transferase activity|protein modification process|sterol binding|ion transport|cortical endoplasmic reticulum|protein localization to membrane|response to peptide hormone|lipid transport|positive regulation of protein metabolic process|negative regulation of cell migration|cellular protein localization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|sequestering of triglyceride|cellular protein metabolic process|carboxylic acid binding|regulation of phosphorus metabolic process|endoplasmic reticulum tubular network|regulation of glucose import in response to insulin stimulus|cellular response to organic substance|nucleus organization|regulation of protein metabolic process|positive regulation of glucose import in response to insulin stimulus|cell differentiation|regulation of insulin receptor signaling pathway|regulation of intracellular signal transduction|carbohydrate transport|cellular response to hormone stimulus|nucleus|regulation of glucose transport|phospholipid transport|regulation of protein kinase B signaling|protein kinase B signaling|anion transport|organic anion transport|fat cell differentiation|protein localization to organelle|positive regulation of protein modification process|cellular response to peptide|regulation of glucose import|phosphorylation|positive regulation of protein kinase B signaling|protein localization to nuclear pore|enzyme linked receptor protein signaling pathway|phosphatidylinositol phosphate binding|cellular response to peptide hormone stimulus|amino acid binding|response to insulin|cholesterol binding|cellular protein modification process|protein localization to nuclear envelope|regulation of kinase activity|positive regulation of kinase activity|regulation of protein kinase activity|hexose transport|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|phosphatidylinositol-4-phosphate binding|positive regulation of protein phosphorylation|positive regulation of phosphorylation|protein localization to nucleus|transmembrane receptor protein tyrosine kinase signaling pathway|glucose transport|activation of protein kinase activity|insulin receptor signaling pathway|glucose import|activation of protein kinase B activity - - - - 12:76351797-76559809 79 112 128 407 214 454 0.311423505696956 0.401258238567531 0.454937049181794 1.43753574538114 0.692163594457733 1.67730362828833 0.389206264482094 1.26900098937573 -1.70508635761212 6.24917493869745e-07 8.05539156389783e-06 DOWN ENSG00000071205 ARHGAP10 Rho GTPase activating protein 10 [Source:HGNC Symbol;Acc:HGNC:26099] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0023051|GO:0016043|GO:0071944|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0010941|GO:0008047|GO:0005737|GO:0009966|GO:0060548|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0006996|GO:0005829|GO:0005096|GO:0007010|GO:0051345|GO:0043069|GO:0030695|GO:0048471|GO:0012501|GO:0035556|GO:1902531|GO:0043067|GO:0043087|GO:0043547|GO:0042981|GO:0043066|GO:0051056|GO:0007264|GO:0006915 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|regulation of signaling|cellular component organization|cell periphery|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|regulation of metabolic process|regulation of cell death|enzyme activator activity|cytoplasm|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|organelle organization|cytosol|GTPase activator activity|cytoskeleton organization|positive regulation of hydrolase activity|negative regulation of programmed cell death|GTPase regulator activity|perinuclear region of cytoplasm|programmed cell death|intracellular signal transduction|regulation of intracellular signal transduction|regulation of programmed cell death|regulation of GTPase activity|positive regulation of GTPase activity|regulation of apoptotic process|negative regulation of apoptotic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|apoptotic process K13736 Rho GTPase-activating protein 10[-] hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) 4:147732063-148072780 94 122 227 436 436 399 0.500699263695181 0.59059117873844 1.09015441922503 2.08080496712344 1.90546991063089 1.99181676904958 0.72714828721955 1.9926972156013 -1.45440100582007 6.37702245288726e-07 8.21664343152768e-06 DOWN ENSG00000157216 SSBP3 single stranded DNA binding protein 3 [Source:HGNC Symbol;Acc:HGNC:15674] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:2000744|GO:0008284|GO:0042127|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0021547|GO:0031325|GO:0046483|GO:0007420|GO:0022607|GO:0021501|GO:0043231|GO:0007389|GO:0060322|GO:0021915|GO:0006139|GO:0010171|GO:0060323|GO:0048869|GO:0030917|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0030097|GO:0007417|GO:0060896|GO:0051252|GO:0009790|GO:0010628|GO:0003002|GO:0021532|GO:0006461|GO:0060429|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0009792|GO:0021903|GO:0003697|GO:0032774|GO:2001141|GO:0009952|GO:0002244|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0021999|GO:0043009 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of anterior head development|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|midbrain-hindbrain boundary initiation|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|cellular component assembly|prechordal plate formation|intracellular membrane-bounded organelle|pattern specification process|head development|neural tube development|nucleobase-containing compound metabolic process|body morphogenesis|head morphogenesis|cellular developmental process|midbrain-hindbrain boundary development|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|hemopoiesis|central nervous system development|neural plate pattern specification|regulation of RNA metabolic process|embryo development|positive regulation of gene expression|regionalization|neural tube patterning|protein complex assembly|epithelium development|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|rostrocaudal neural tube patterning|single-stranded DNA binding|RNA biosynthetic process|regulation of RNA biosynthetic process|anterior/posterior pattern specification|hematopoietic progenitor cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|neural plate anterior/posterior regionalization|chordate embryonic development - - - - 1:54225432-54413479 128 136 258 433 536 450 0.859448848890224 0.829907269364352 1.56187346227144 2.6049339786127 2.95286795952628 2.83173448578495 1.08374319350867 2.79651214130798 -1.36760566135367 6.38685263821312e-07 8.22221210268281e-06 DOWN ENSG00000167720 SRR serine racemase [Source:HGNC Symbol;Acc:HGNC:14398] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0006807|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0045177|GO:0044297|GO:0016043|GO:0051707|GO:0048037|GO:0071944|GO:0009607|GO:0009605|GO:0016853|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0042802|GO:0016854|GO:0043025|GO:0006082|GO:0007275|GO:0048513|GO:0043168|GO:0044281|GO:0001882|GO:0007420|GO:0022607|GO:0043169|GO:0010243|GO:0005737|GO:0006520|GO:0060322|GO:0043177|GO:0046983|GO:0036477|GO:0019904|GO:0042493|GO:0009617|GO:0030170|GO:0000166|GO:0044249|GO:0010033|GO:0007568|GO:0046872|GO:0033993|GO:0035639|GO:0007417|GO:0002237|GO:0001883|GO:0030165|GO:0032549|GO:0016841|GO:0043279|GO:0008652|GO:0006461|GO:0014070|GO:0060359|GO:0031406|GO:0007399|GO:0017076|GO:0032496|GO:0016594|GO:0042803|GO:0051259|GO:0000287|GO:0005524|GO:0030554|GO:0046416|GO:0005509|GO:0003941|GO:0008721|GO:0043278|GO:0016597|GO:0019752|GO:0009069|GO:0006563|GO:0070178|GO:0009070|GO:0032787|GO:0051260|GO:0051262|GO:0030378|GO:0051289|GO:0018114|GO:0042866|GO:0070179|GO:0006090 developmental process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|apical part of cell|cell body|cellular component organization|response to other organism|cofactor binding|cell periphery|response to biotic stimulus|response to external stimulus|isomerase activity|biosynthetic process|intracellular|protein binding|plasma membrane|anatomical structure development|identical protein binding|racemase and epimerase activity|neuronal cell body|organic acid metabolic process|multicellular organism development|animal organ development|anion binding|small molecule metabolic process|nucleoside binding|brain development|cellular component assembly|cation binding|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|head development|organic acid binding|protein dimerization activity|somatodendritic compartment|protein domain specific binding|response to drug|response to bacterium|pyridoxal phosphate binding|nucleotide binding|cellular biosynthetic process|response to organic substance|aging|metal ion binding|response to lipid|purine ribonucleoside triphosphate binding|central nervous system development|response to molecule of bacterial origin|purine nucleoside binding|PDZ domain binding|ribonucleoside binding|ammonia-lyase activity|response to alkaloid|cellular amino acid biosynthetic process|protein complex assembly|response to organic cyclic compound|response to ammonium ion|carboxylic acid binding|nervous system development|purine nucleotide binding|response to lipopolysaccharide|glycine binding|protein homodimerization activity|protein oligomerization|magnesium ion binding|ATP binding|adenyl nucleotide binding|D-amino acid metabolic process|calcium ion binding|L-serine ammonia-lyase activity|D-serine ammonia-lyase activity|response to morphine|amino acid binding|carboxylic acid metabolic process|serine family amino acid metabolic process|L-serine metabolic process|D-serine metabolic process|serine family amino acid biosynthetic process|monocarboxylic acid metabolic process|protein homooligomerization|protein tetramerization|serine racemase activity|protein homotetramerization|threonine racemase activity|pyruvate biosynthetic process|D-serine biosynthetic process|pyruvate metabolic process K12235 serine racemase[5.1.1.18] hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) 17:2303383-2325260 225 257 258 577 577 557 3.6188753215665 3.75667736675278 3.74132262961111 8.31502993383555 7.61437246482196 8.39604690334595 3.7056251059768 8.10848310066782 -1.12971511377124 6.38455147264848e-07 8.22221210268281e-06 DOWN ENSG00000213463 SYNJ2BP synaptojanin 2 binding protein [Source:HGNC Symbol;Acc:HGNC:18955] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0071704|GO:0009986|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0019867|GO:0023057|GO:0009893|GO:0031224|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0048514|GO:0060341|GO:0042127|GO:0051640|GO:0008022|GO:0006810|GO:0031623|GO:0051130|GO:0001568|GO:0007275|GO:0010632|GO:0060627|GO:0005102|GO:0031325|GO:0051128|GO:0045807|GO:0043231|GO:0005737|GO:0032880|GO:0006928|GO:2000010|GO:0009966|GO:0050673|GO:0031966|GO:0045184|GO:0010646|GO:0001525|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0051649|GO:0051271|GO:0008285|GO:0016021|GO:2000145|GO:0009967|GO:0010633|GO:0019538|GO:0023014|GO:0031301|GO:0031324|GO:0031323|GO:2000146|GO:0006996|GO:0016525|GO:0000165|GO:0016192|GO:0032268|GO:0051646|GO:0005740|GO:0002040|GO:0090132|GO:0090101|GO:0007166|GO:0001944|GO:0043412|GO:0072358|GO:0002090|GO:0007005|GO:0005741|GO:0048260|GO:0015031|GO:0030334|GO:0001935|GO:0001667|GO:0036211|GO:0032269|GO:0046907|GO:0033612|GO:0031306|GO:0045765|GO:0030100|GO:0008593|GO:0002092|GO:0005739|GO:0050678|GO:0050680|GO:0030336|GO:0034613|GO:0006796|GO:1901342|GO:0032592|GO:0035556|GO:0044267|GO:0051174|GO:1902532|GO:0010594|GO:0051246|GO:1903827|GO:1902531|GO:0072359|GO:0010596|GO:0048311|GO:0043112|GO:0032926|GO:2000008|GO:0032925|GO:0043408|GO:0048259|GO:0016310|GO:0006605|GO:0070371|GO:0034394|GO:0001936|GO:0006886|GO:0007167|GO:0001937|GO:0010631|GO:0043409|GO:1903671|GO:0031307|GO:0006897|GO:0007219|GO:0007264|GO:0006464|GO:0032927|GO:0048312|GO:0007265|GO:0006468|GO:0042325|GO:0001932|GO:0042326|GO:0006898|GO:0007178|GO:0001933|GO:0070372|GO:0043542|GO:0070373|GO:0032924|GO:0007266|GO:0070699 locomotion|developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|organic substance metabolic process|cell surface|cellular metabolic process|cellular localization|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|outer membrane|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|regulation of cell proliferation|organelle localization|protein C-terminus binding|transport|receptor internalization|positive regulation of cellular component organization|blood vessel development|multicellular organism development|regulation of epithelial cell migration|regulation of vesicle-mediated transport|receptor binding|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of endocytosis|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|movement of cell or subcellular component|positive regulation of protein localization to cell surface|regulation of signal transduction|epithelial cell proliferation|mitochondrial membrane|establishment of protein localization|regulation of cell communication|angiogenesis|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|establishment of localization in cell|negative regulation of cellular component movement|negative regulation of cell proliferation|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|negative regulation of epithelial cell migration|protein metabolic process|signal transduction by protein phosphorylation|integral component of organelle membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|organelle organization|negative regulation of angiogenesis|MAPK cascade|vesicle-mediated transport|regulation of cellular protein metabolic process|mitochondrion localization|mitochondrial envelope|sprouting angiogenesis|epithelium migration|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|vasculature development|macromolecule modification|cardiovascular system development|regulation of receptor internalization|mitochondrion organization|mitochondrial outer membrane|positive regulation of receptor-mediated endocytosis|protein transport|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|protein modification process|negative regulation of cellular protein metabolic process|intracellular transport|receptor serine/threonine kinase binding|intrinsic component of mitochondrial outer membrane|regulation of angiogenesis|regulation of endocytosis|regulation of Notch signaling pathway|positive regulation of receptor internalization|mitochondrion|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of cell migration|cellular protein localization|phosphate-containing compound metabolic process|regulation of vasculature development|integral component of mitochondrial membrane|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|negative regulation of intracellular signal transduction|regulation of endothelial cell migration|regulation of protein metabolic process|regulation of cellular protein localization|regulation of intracellular signal transduction|circulatory system development|negative regulation of endothelial cell migration|mitochondrion distribution|receptor metabolic process|negative regulation of activin receptor signaling pathway|regulation of protein localization to cell surface|regulation of activin receptor signaling pathway|regulation of MAPK cascade|regulation of receptor-mediated endocytosis|phosphorylation|protein targeting|ERK1 and ERK2 cascade|protein localization to cell surface|regulation of endothelial cell proliferation|intracellular protein transport|enzyme linked receptor protein signaling pathway|negative regulation of endothelial cell proliferation|epithelial cell migration|negative regulation of MAPK cascade|negative regulation of sprouting angiogenesis|integral component of mitochondrial outer membrane|endocytosis|Notch signaling pathway|small GTPase mediated signal transduction|cellular protein modification process|positive regulation of activin receptor signaling pathway|intracellular distribution of mitochondria|Ras protein signal transduction|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|receptor-mediated endocytosis|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|endothelial cell migration|negative regulation of ERK1 and ERK2 cascade|activin receptor signaling pathway|Rho protein signal transduction|type II activin receptor binding - - - - 14:70366496-70417061 207 307 529 785 1033 972 1.87220857565958 2.52349215738808 4.31373077656131 6.36136941104028 7.66570132903219 8.23908118315282 2.90314383653632 7.4220506410751 -1.35420179246185 6.44022711925894e-07 8.28735088010157e-06 DOWN ENSG00000204954 C12orf73 chromosome 12 open reading frame 73 [Source:HGNC Symbol;Acc:HGNC:34450] GO:0005576 extracellular region - - - - 12:103950202-103965708 240 214 237 118 105 86 1.85966154441301 1.50700872438612 1.65571598283224 0.819222711661553 0.667545562017199 0.624523964288287 1.67412875054379 0.703764079322346 1.25024669927962 6.50851036166573e-07 8.37161001021839e-06 UP ENSG00000164082 GRM2 glutamate receptor, metabotropic 2 [Source:HGNC Symbol;Acc:HGNC:4594] GO:0004871|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0038023|GO:0071944|GO:0009058|GO:0031224|GO:0016247|GO:0005622|GO:0005515|GO:0005886|GO:0097060|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0044281|GO:0032940|GO:0019637|GO:0046483|GO:0005887|GO:0004888|GO:0007267|GO:0042734|GO:0005246|GO:0043005|GO:0009890|GO:0036477|GO:0006139|GO:0031226|GO:0055086|GO:0007154|GO:0044092|GO:0007165|GO:0050790|GO:0043086|GO:0016021|GO:0044249|GO:0031324|GO:0031323|GO:0007186|GO:0007166|GO:0051350|GO:0030424|GO:0019693|GO:0031279|GO:0006811|GO:0030425|GO:0008066|GO:0006796|GO:1901137|GO:0051174|GO:0046903|GO:0014047|GO:0004930|GO:0006820|GO:0007216|GO:0015711|GO:0007187|GO:0007215|GO:0009259|GO:0009117|GO:0046390|GO:0045980|GO:0001640|GO:0007194|GO:0046942|GO:0045761|GO:0006163|GO:0006865|GO:0009165|GO:0046717|GO:0006164|GO:0007188|GO:0006835|GO:0009187|GO:0001641|GO:0007196|GO:0030802|GO:0007268|GO:0009190|GO:0007193|GO:0030818|GO:0046058|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030815|GO:0006171 signal transducer activity|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|signaling receptor activity|cell periphery|biosynthetic process|intrinsic component of membrane|channel regulator activity|intracellular|protein binding|plasma membrane|synaptic membrane|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|organophosphate metabolic process|heterocycle metabolic process|integral component of plasma membrane|transmembrane signaling receptor activity|cell-cell signaling|presynaptic membrane|calcium channel regulator activity|neuron projection|negative regulation of biosynthetic process|somatodendritic compartment|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|nucleobase-containing small molecule metabolic process|cell communication|negative regulation of molecular function|signal transduction|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|negative regulation of lyase activity|axon|ribose phosphate metabolic process|regulation of cyclase activity|ion transport|dendrite|glutamate receptor activity|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|secretion|glutamate secretion|G-protein coupled receptor activity|anion transport|G-protein coupled glutamate receptor signaling pathway|organic anion transport|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|glutamate receptor signaling pathway|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|negative regulation of nucleotide metabolic process|adenylate cyclase inhibiting G-protein coupled glutamate receptor activity|negative regulation of adenylate cyclase activity|carboxylic acid transport|regulation of adenylate cyclase activity|purine nucleotide metabolic process|amino acid transport|nucleotide biosynthetic process|acid secretion|purine nucleotide biosynthetic process|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|dicarboxylic acid transport|cyclic nucleotide metabolic process|group II metabotropic glutamate receptor activity|adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|cyclic nucleotide biosynthetic process|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of cAMP biosynthetic process|cAMP metabolic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|negative regulation of cAMP metabolic process|cAMP biosynthetic process K04605 metabotropic glutamate receptor 2/3[-] hsa04080|hsa04072|hsa04724|hsa05030 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human) 3:51707070-51718613 29 24 3 1 0 0 0.168048883175238 0.126394302441031 0.0156714001649276 0.00518954644882543 0 0 0.103371528593732 0.00172984881627514 5.90104911558246 6.61882926548993e-07 8.50617860059993e-06 UP ENSG00000055483 USP36 ubiquitin specific peptidase 36 [Source:HGNC Symbol;Acc:HGNC:20062] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0016787|GO:0005622|GO:1903829|GO:0019222|GO:0060341|GO:0010506|GO:0006810|GO:0051130|GO:0009991|GO:0003676|GO:0051128|GO:0033554|GO:0043231|GO:0008233|GO:0032880|GO:0051222|GO:0045184|GO:0032388|GO:0010646|GO:0008104|GO:0007154|GO:0000422|GO:0051649|GO:0090316|GO:0016236|GO:0019538|GO:0031323|GO:0006996|GO:0005730|GO:0036459|GO:1903008|GO:0003723|GO:0043412|GO:0072594|GO:0030163|GO:0007005|GO:0032386|GO:0051223|GO:1903955|GO:0015031|GO:1903146|GO:0044265|GO:0036211|GO:0070201|GO:0046907|GO:0016241|GO:0031981|GO:0006508|GO:0034613|GO:0033043|GO:0044267|GO:0006626|GO:1903827|GO:0031667|GO:0005634|GO:0010638|GO:0044257|GO:0033365|GO:0033157|GO:0006839|GO:0006605|GO:0072655|GO:0010822|GO:0016482|GO:0006886|GO:0051603|GO:0010821|GO:0070646|GO:0044822|GO:0004843|GO:0008234|GO:0006464|GO:1903214|GO:1903533|GO:0019941|GO:0016579|GO:0070585|GO:0006511 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|hydrolase activity|intracellular|positive regulation of cellular protein localization|regulation of metabolic process|regulation of cellular localization|regulation of autophagy|transport|positive regulation of cellular component organization|response to extracellular stimulus|nucleic acid binding|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|peptidase activity|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|positive regulation of intracellular transport|regulation of cell communication|protein localization|cell communication|mitophagy|establishment of localization in cell|positive regulation of intracellular protein transport|macroautophagy|protein metabolic process|regulation of cellular metabolic process|organelle organization|nucleolus|thiol-dependent ubiquitinyl hydrolase activity|organelle disassembly|RNA binding|macromolecule modification|establishment of protein localization to organelle|protein catabolic process|mitochondrion organization|regulation of intracellular transport|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|regulation of mitophagy|cellular macromolecule catabolic process|protein modification process|regulation of establishment of protein localization|intracellular transport|regulation of macroautophagy|nuclear lumen|proteolysis|cellular protein localization|regulation of organelle organization|cellular protein metabolic process|protein targeting to mitochondrion|regulation of cellular protein localization|response to nutrient levels|nucleus|positive regulation of organelle organization|cellular protein catabolic process|protein localization to organelle|regulation of intracellular protein transport|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|proteolysis involved in cellular protein catabolic process|regulation of mitochondrion organization|protein modification by small protein removal|poly(A) RNA binding|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|regulation of protein targeting to mitochondrion|regulation of protein targeting|modification-dependent protein catabolic process|protein deubiquitination|protein localization to mitochondrion|ubiquitin-dependent protein catabolic process - - - - 17:78787381-78841441 1230 1263 1105 623 765 514 4.45569336529553 4.1580864341598 3.60899840613718 2.02206978802228 2.27373324406625 1.74502866010763 4.07425940186417 2.01361056406539 1.01675314692898 6.62464781439254e-07 8.50999293678463e-06 UP ENSG00000115568 ZNF142 zinc finger protein 142 [Source:HGNC Symbol;Acc:HGNC:12927] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 2:218637916-218659655 1018 1180 836 539 594 404 6.92072526570166 7.29064278250202 5.12417585332283 3.28314824472591 3.31327997306857 2.57403420822849 6.44518130050884 3.05682080867432 1.07618895793372 6.6602396133159e-07 8.55203412541646e-06 UP ENSG00000167693 NXN nucleoredoxin [Source:HGNC Symbol;Acc:HGNC:18008] GO:0016209|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0004791|GO:0023057|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0098869|GO:0007275|GO:0043231|GO:0005737|GO:0009966|GO:0016667|GO:0010646|GO:0016651|GO:0007154|GO:0007165|GO:0009968|GO:0048869|GO:0019538|GO:0031324|GO:0031323|GO:0055114|GO:0009636|GO:0032268|GO:0030111|GO:0005829|GO:0030178|GO:0007166|GO:0043412|GO:0072358|GO:0036211|GO:0032269|GO:0044267|GO:0051246|GO:0030154|GO:0016668|GO:0072359|GO:0005634|GO:0016055|GO:0047134|GO:0006464|GO:0032446|GO:0031396|GO:0031397|GO:0016567 antioxidant activity|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|thioredoxin-disulfide reductase activity|negative regulation of signaling|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular oxidant detoxification|multicellular organism development|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|oxidoreductase activity, acting on a sulfur group of donors|regulation of cell communication|oxidoreductase activity, acting on NAD(P)H|cell communication|signal transduction|negative regulation of signal transduction|cellular developmental process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|oxidation-reduction process|response to toxic substance|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cytosol|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|macromolecule modification|cardiovascular system development|protein modification process|negative regulation of cellular protein metabolic process|cellular protein metabolic process|regulation of protein metabolic process|cell differentiation|oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor|circulatory system development|nucleus|Wnt signaling pathway|protein-disulfide reductase activity|cellular protein modification process|protein modification by small protein conjugation|regulation of protein ubiquitination|negative regulation of protein ubiquitination|protein ubiquitination - - - - 17:799313-979770 348 323 667 1012 1283 1063 2.74583450553181 2.31621070788592 4.7449926752896 7.15440522241017 8.30596540822801 7.86063155943275 3.26901262956911 7.77366739669031 -1.24974043114745 6.66666566830011e-07 8.55660519610625e-06 DOWN ENSG00000204876 AC021218.2 - - - - - - - 7:155962632-155966343 12 10 16 40 55 66 0.33472753009735 0.253498825232924 0.402385186099139 0.999672707437438 1.25870765172121 1.72532465651917 0.330203847143138 1.32790167189261 -2.00771948831254 6.76485959287384e-07 8.67890495426109e-06 DOWN ENSG00000115816 CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta [Source:HGNC Symbol;Acc:HGNC:24218] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0044249|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0003723|GO:0051252|GO:0010628|GO:0010467|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0003690|GO:0044822|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|regulation of RNA metabolic process|positive regulation of gene expression|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 2:37201612-37231713 2589 2974 2532 1518 1667 1064 38.1139873058757 39.7899437628336 33.6070390238071 20.0226564471094 20.1351948248143 14.6798997278757 37.1703233641721 18.2792503332665 1.02394433506772 6.82116255679384e-07 8.74362331346172e-06 UP ENSG00000157916 RER1 retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0009986|GO:0051641|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:1903829|GO:0005515|GO:0012505|GO:0031090|GO:0060341|GO:0031228|GO:0006810|GO:0051130|GO:0005102|GO:0051128|GO:0051668|GO:0043231|GO:0005737|GO:0032880|GO:0045184|GO:0008104|GO:0061024|GO:0090004|GO:0050808|GO:0051649|GO:0016021|GO:0031301|GO:0010256|GO:0005794|GO:0016192|GO:0043113|GO:0090150|GO:0005793|GO:0007528|GO:0007009|GO:0030173|GO:0070201|GO:0046907|GO:0072657|GO:0034613|GO:1903078|GO:0001941|GO:0000139|GO:1903827|GO:0033130|GO:0090003|GO:0071340|GO:0072659|GO:0090002|GO:0048193|GO:1903076|GO:1990778|GO:0006890 cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|cell surface|cellular localization|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|positive regulation of cellular protein localization|protein binding|endomembrane system|organelle membrane|regulation of cellular localization|intrinsic component of Golgi membrane|transport|positive regulation of cellular component organization|receptor binding|regulation of cellular component organization|localization within membrane|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|establishment of protein localization|protein localization|membrane organization|positive regulation of establishment of protein localization to plasma membrane|synapse organization|establishment of localization in cell|integral component of membrane|integral component of organelle membrane|endomembrane system organization|Golgi apparatus|vesicle-mediated transport|receptor clustering|establishment of protein localization to membrane|endoplasmic reticulum-Golgi intermediate compartment|neuromuscular junction development|plasma membrane organization|integral component of Golgi membrane|regulation of establishment of protein localization|intracellular transport|protein localization to membrane|cellular protein localization|positive regulation of protein localization to plasma membrane|postsynaptic membrane organization|Golgi membrane|regulation of cellular protein localization|acetylcholine receptor binding|regulation of establishment of protein localization to plasma membrane|skeletal muscle acetylcholine-gated channel clustering|protein localization to plasma membrane|establishment of protein localization to plasma membrane|Golgi vesicle transport|regulation of protein localization to plasma membrane|protein localization to cell periphery|retrograde vesicle-mediated transport, Golgi to ER - - - - 1:2391775-2405444 624 551 702 1318 1682 1259 3.90375850084645 3.13277915187275 3.95958766955685 7.3877370243635 8.63360845661132 7.38164503638073 3.66537510742535 7.80099683911852 -1.08969763991268 6.86636406114536e-07 8.79778681036196e-06 DOWN ENSG00000158050 DUSP2 dual specificity phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:3068] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0043227|GO:0023057|GO:0016787|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0009888|GO:0007275|GO:0016788|GO:0043231|GO:0019899|GO:0009966|GO:0048598|GO:0010646|GO:0007154|GO:0001704|GO:0044092|GO:0007165|GO:0009968|GO:0050790|GO:0043086|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0000165|GO:0032268|GO:0043412|GO:0007492|GO:0009790|GO:0036211|GO:0032269|GO:0007369|GO:0001706|GO:0019900|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:1902532|GO:0051246|GO:1902531|GO:0005634|GO:0042578|GO:0016311|GO:0043408|GO:0016310|GO:0016791|GO:0043409|GO:0033673|GO:0019901|GO:0006464|GO:0043549|GO:0006470|GO:0045859|GO:0006469|GO:0006468|GO:0043407|GO:0043405|GO:0042325|GO:0004721|GO:0001932|GO:0051019|GO:0042326|GO:0001933|GO:0035335|GO:0071901|GO:0000188|GO:0008138|GO:0033549|GO:0071900|GO:0004725|GO:0008330|GO:0017017 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|negative regulation of signaling|hydrolase activity|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|tissue development|multicellular organism development|hydrolase activity, acting on ester bonds|intracellular membrane-bounded organelle|enzyme binding|regulation of signal transduction|embryonic morphogenesis|regulation of cell communication|cell communication|formation of primary germ layer|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|macromolecule modification|endoderm development|embryo development|protein modification process|negative regulation of cellular protein metabolic process|gastrulation|endoderm formation|kinase binding|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|negative regulation of intracellular signal transduction|regulation of protein metabolic process|regulation of intracellular signal transduction|nucleus|phosphoric ester hydrolase activity|dephosphorylation|regulation of MAPK cascade|phosphorylation|phosphatase activity|negative regulation of MAPK cascade|negative regulation of kinase activity|protein kinase binding|cellular protein modification process|regulation of kinase activity|protein dephosphorylation|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|negative regulation of MAP kinase activity|regulation of MAP kinase activity|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|mitogen-activated protein kinase binding|negative regulation of phosphorylation|negative regulation of protein phosphorylation|peptidyl-tyrosine dephosphorylation|negative regulation of protein serine/threonine kinase activity|inactivation of MAPK activity|protein tyrosine/serine/threonine phosphatase activity|MAP kinase phosphatase activity|regulation of protein serine/threonine kinase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity|MAP kinase tyrosine/serine/threonine phosphatase activity K04459 dual specificity MAP kinase phosphatase[3.1.3.48] hsa04010 MAPK signaling pathway - Homo sapiens (human) 2:96143166-96145440 249 287 274 93 150 56 7.15704406174495 7.49714998835872 7.10065786616145 2.3950405845971 3.53746698495417 1.50853123055873 7.25161730542171 2.48034626670333 1.54776124982693 6.87715451451613e-07 8.80783229842834e-06 UP ENSG00000186153 WWOX WW domain containing oxidoreductase [Source:HGNC Symbol;Acc:HGNC:12799] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0042995|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0000989|GO:0009653|GO:0043227|GO:0048037|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0010942|GO:0043231|GO:0019899|GO:0005737|GO:0001076|GO:0071559|GO:0009887|GO:0005667|GO:0009966|GO:0046983|GO:0010646|GO:0006139|GO:0007154|GO:0006629|GO:0007165|GO:0009968|GO:0001503|GO:0008219|GO:0050662|GO:0048869|GO:0009967|GO:0044249|GO:0010033|GO:0031323|GO:0005794|GO:0055114|GO:0003713|GO:2001235|GO:0030111|GO:0005829|GO:0048705|GO:0010468|GO:0034645|GO:0030178|GO:0007166|GO:0044798|GO:0001104|GO:0051252|GO:0010628|GO:0071560|GO:0001649|GO:0070848|GO:0005739|GO:0008202|GO:0012501|GO:0035556|GO:0010467|GO:0071310|GO:0005902|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0043068|GO:0001191|GO:0016070|GO:0010557|GO:0005634|GO:0043067|GO:0097190|GO:0016055|GO:0045893|GO:0097193|GO:0043065|GO:0072331|GO:0032774|GO:2001141|GO:0097192|GO:2001236|GO:0071363|GO:2001238|GO:0001105|GO:0042981|GO:0090575|GO:0097191|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0072332|GO:0006357|GO:1903506|GO:2001239|GO:0001190|GO:2001241 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|membrane-bounded organelle|cofactor binding|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell death|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|transcription factor activity, RNA polymerase II transcription factor binding|response to transforming growth factor beta|organ morphogenesis|transcription factor complex|regulation of signal transduction|protein dimerization activity|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|lipid metabolic process|signal transduction|negative regulation of signal transduction|ossification|cell death|coenzyme binding|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|oxidation-reduction process|transcription coactivator activity|positive regulation of apoptotic signaling pathway|regulation of Wnt signaling pathway|cytosol|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|nuclear transcription factor complex|RNA polymerase II transcription cofactor activity|regulation of RNA metabolic process|positive regulation of gene expression|cellular response to transforming growth factor beta stimulus|osteoblast differentiation|response to growth factor|mitochondrion|steroid metabolic process|programmed cell death|intracellular signal transduction|gene expression|cellular response to organic substance|microvillus|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|positive regulation of programmed cell death|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|apoptotic signaling pathway|Wnt signaling pathway|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|positive regulation of apoptotic process|signal transduction by p53 class mediator|RNA biosynthetic process|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|regulation of extrinsic apoptotic signaling pathway|cellular response to growth factor stimulus|positive regulation of extrinsic apoptotic signaling pathway|RNA polymerase II transcription coactivator activity|regulation of apoptotic process|RNA polymerase II transcription factor complex|extrinsic apoptotic signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|regulation of extrinsic apoptotic signaling pathway in absence of ligand|transcriptional activator activity, RNA polymerase II transcription factor binding|positive regulation of extrinsic apoptotic signaling pathway in absence of ligand - - - - 16:78099413-79212667 40 47 42 158 148 104 0.31168484686323 0.332841333154234 0.295066251983722 1.1030903415752 0.946203780144573 0.759480471501157 0.313197477333729 0.93625819774031 -1.57983385324482 6.88937338299811e-07 8.81969781200796e-06 DOWN ENSG00000180257 ZNF816 zinc finger protein 816 [Source:HGNC Symbol;Acc:HGNC:26995] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0016021|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|membrane|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|integral component of membrane|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:52949379-52962911 92 83 63 24 34 21 0.903487310284003 0.740785297406724 0.557811627552734 0.211172614792724 0.273952230686379 0.193272481803816 0.734028078414487 0.22613244242764 1.69866726549594 6.92915787507576e-07 8.86682722685434e-06 UP ENSG00000124383 MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) [Source:HGNC Symbol;Acc:HGNC:7213] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0044092|GO:0034457|GO:0050790|GO:0043086|GO:0022613|GO:0019538|GO:0031324|GO:0031323|GO:0005730|GO:0032268|GO:0003723|GO:0030684|GO:0043412|GO:0042254|GO:0005732|GO:0036211|GO:0032269|GO:0031981|GO:0051346|GO:0005694|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0051246|GO:0016070|GO:0005634|GO:0006364|GO:0010923|GO:0016311|GO:0030686|GO:0006396|GO:0034660|GO:0032040|GO:0044822|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0016072|GO:0035305|GO:0008380|GO:0035303|GO:0035308|GO:0000375 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|negative regulation of molecular function|Mpp10 complex|regulation of catalytic activity|negative regulation of catalytic activity|ribonucleoprotein complex biogenesis|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|nucleolus|regulation of cellular protein metabolic process|RNA binding|preribosome|macromolecule modification|ribosome biogenesis|small nucleolar ribonucleoprotein complex|protein modification process|negative regulation of cellular protein metabolic process|nuclear lumen|negative regulation of hydrolase activity|chromosome|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of protein metabolic process|RNA metabolic process|nucleus|rRNA processing|negative regulation of phosphatase activity|dephosphorylation|90S preribosome|RNA processing|ncRNA metabolic process|small-subunit processome|poly(A) RNA binding|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|rRNA metabolic process|negative regulation of dephosphorylation|RNA splicing|regulation of dephosphorylation|negative regulation of protein dephosphorylation|RNA splicing, via transesterification reactions K14559 U3 small nucleolar RNA-associated protein MPP10[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 2:71130314-71150101 2095 2045 1634 1041 1119 728 25.8267233610257 22.9117610447868 18.1614848867422 11.4983017576506 11.3183578209663 8.41095975523062 22.2999897641849 10.4092064446158 1.09918296028883 6.93569589563913e-07 8.87139097122582e-06 UP ENSG00000109654 TRIM2 tripartite motif containing 2 [Source:HGNC Symbol;Acc:HGNC:15974] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0010941|GO:0043169|GO:0005737|GO:0008219|GO:0019787|GO:0019538|GO:0046872|GO:0043412|GO:0004842|GO:0070997|GO:0036211|GO:1901214|GO:0012501|GO:0044267|GO:0043067|GO:0043523|GO:0042981|GO:0046914|GO:0051402|GO:0006464|GO:0006915|GO:0008270|GO:0032446|GO:0016567 cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|ligase activity|intracellular|protein binding|transferase activity|regulation of cell death|cation binding|cytoplasm|cell death|ubiquitin-like protein transferase activity|protein metabolic process|metal ion binding|macromolecule modification|ubiquitin-protein transferase activity|neuron death|protein modification process|regulation of neuron death|programmed cell death|cellular protein metabolic process|regulation of programmed cell death|regulation of neuron apoptotic process|regulation of apoptotic process|transition metal ion binding|neuron apoptotic process|cellular protein modification process|apoptotic process|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 4:153152342-153339320 471 559 975 1499 1552 2108 2.54212309483327 2.74199849586889 4.7445418405409 7.24894889410568 6.87282512043939 10.6628956147627 3.34288781041435 8.26155654310259 -1.30531868455671 6.95999405538757e-07 8.89865792417733e-06 DOWN ENSG00000242498 ARPIN actin-related protein 2/3 complex inhibitor [Source:HGNC Symbol;Acc:HGNC:28782] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0040013|GO:0042995|GO:0048523|GO:0050794|GO:0040012|GO:0044089|GO:0048870|GO:0009653|GO:0016043|GO:0033058|GO:0031252|GO:0050793|GO:0005515|GO:0048856|GO:0051130|GO:0032535|GO:0051128|GO:0022607|GO:0032970|GO:2000393|GO:0006928|GO:0030027|GO:0051270|GO:0016477|GO:0051271|GO:0030030|GO:0048869|GO:0030029|GO:2000145|GO:0031334|GO:0043254|GO:2000146|GO:0006996|GO:0000902|GO:0031344|GO:0032956|GO:0007010|GO:0030334|GO:0031345|GO:0022604|GO:0006461|GO:0030036|GO:0030336|GO:0097581|GO:0032273|GO:0033043|GO:0032990|GO:0030832|GO:0048858|GO:0010638|GO:0034622|GO:0030838|GO:0043623|GO:0072673|GO:0008064|GO:0051494|GO:0051493|GO:0007015|GO:0051495|GO:0030833|GO:2000392|GO:0051125|GO:0051258|GO:0051126|GO:0045010|GO:0008154|GO:0030041 locomotion|developmental process|cell|cellular process|binding|negative regulation of locomotion|cell projection|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|positive regulation of cellular component biogenesis|cell motility|anatomical structure morphogenesis|cellular component organization|directional locomotion|cell leading edge|regulation of developmental process|protein binding|anatomical structure development|positive regulation of cellular component organization|regulation of cellular component size|regulation of cellular component organization|cellular component assembly|regulation of actin filament-based process|negative regulation of lamellipodium morphogenesis|movement of cell or subcellular component|lamellipodium|regulation of cellular component movement|cell migration|negative regulation of cellular component movement|cell projection organization|cellular developmental process|actin filament-based process|regulation of cell motility|positive regulation of protein complex assembly|regulation of protein complex assembly|negative regulation of cell motility|organelle organization|cell morphogenesis|regulation of cell projection organization|regulation of actin cytoskeleton organization|cytoskeleton organization|regulation of cell migration|negative regulation of cell projection organization|regulation of cell morphogenesis|protein complex assembly|actin cytoskeleton organization|negative regulation of cell migration|lamellipodium organization|positive regulation of protein polymerization|regulation of organelle organization|cell part morphogenesis|regulation of actin filament length|cell projection morphogenesis|positive regulation of organelle organization|cellular macromolecular complex assembly|positive regulation of actin filament polymerization|cellular protein complex assembly|lamellipodium morphogenesis|regulation of actin polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|actin filament organization|positive regulation of cytoskeleton organization|regulation of actin filament polymerization|regulation of lamellipodium morphogenesis|regulation of actin nucleation|protein polymerization|negative regulation of actin nucleation|actin nucleation|actin polymerization or depolymerization|actin filament polymerization - - - - 15:89895006-89912956 230 300 485 770 790 1047 1.65105016729408 1.95719409617626 3.13898121209502 4.952464931373 4.65294605354701 7.04383189441046 2.24907515852179 5.54974762644349 -1.30309029349713 6.97644728003079e-07 8.91587573193661e-06 DOWN ENSG00000241549 GUSBP2 glucuronidase, beta pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:18792] - - - - - - 6:26871484-26956554 3 1 3 20 19 21 0.0770918341151268 0.0233627776015036 0.0694881154425251 0.460426056638085 0.40055806513303 0.505681687770753 0.0566475757197185 0.455555269847289 -3.00753997722723 7.03263793022084e-07 8.98384136794235e-06 DOWN ENSG00000130544 ZNF557 zinc finger protein 557 [Source:HGNC Symbol;Acc:HGNC:28632] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:7069444-7087968 140 136 129 56 65 51 1.32112628593722 1.16636513910798 1.09753669801734 0.473479123473673 0.503266061261043 0.451040036655021 1.19500937435418 0.475928407129912 1.32820546209075 7.10659106456715e-07 9.0744298392467e-06 UP ENSG00000102393 GLA galactosidase alpha [Source:HGNC Symbol;Acc:HGNC:4296] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0042802|GO:1903409|GO:0044255|GO:0005102|GO:0016798|GO:0034641|GO:0044281|GO:2001057|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0072593|GO:0016936|GO:0046983|GO:0009890|GO:0044092|GO:0006629|GO:0070062|GO:0050790|GO:0043086|GO:0044249|GO:0031324|GO:0031323|GO:0005794|GO:0009311|GO:0051354|GO:0006665|GO:0016042|GO:0044242|GO:1903427|GO:0005773|GO:0006643|GO:2000377|GO:0046209|GO:0045428|GO:2000378|GO:0051341|GO:0004553|GO:0043603|GO:0005775|GO:0006809|GO:0042803|GO:1903426|GO:0006672|GO:0019377|GO:0006687|GO:0000323|GO:0043202|GO:0006664|GO:0030149|GO:0045019|GO:0046466|GO:0032769|GO:0006677|GO:0005764|GO:0051001|GO:0050999|GO:0046479|GO:0004557|GO:0046514|GO:0052692|GO:0046477 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|endomembrane system|regulation of metabolic process|identical protein binding|reactive oxygen species biosynthetic process|cellular lipid metabolic process|receptor binding|hydrolase activity, acting on glycosyl bonds|cellular nitrogen compound metabolic process|small molecule metabolic process|reactive nitrogen species metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|reactive oxygen species metabolic process|galactoside binding|protein dimerization activity|negative regulation of biosynthetic process|negative regulation of molecular function|lipid metabolic process|extracellular exosome|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|oligosaccharide metabolic process|negative regulation of oxidoreductase activity|sphingolipid metabolic process|lipid catabolic process|cellular lipid catabolic process|negative regulation of reactive oxygen species biosynthetic process|vacuole|membrane lipid metabolic process|regulation of reactive oxygen species metabolic process|nitric oxide metabolic process|regulation of nitric oxide biosynthetic process|negative regulation of reactive oxygen species metabolic process|regulation of oxidoreductase activity|hydrolase activity, hydrolyzing O-glycosyl compounds|cellular amide metabolic process|vacuolar lumen|nitric oxide biosynthetic process|protein homodimerization activity|regulation of reactive oxygen species biosynthetic process|ceramide metabolic process|glycolipid catabolic process|glycosphingolipid metabolic process|lytic vacuole|lysosomal lumen|glycolipid metabolic process|sphingolipid catabolic process|negative regulation of nitric oxide biosynthetic process|membrane lipid catabolic process|negative regulation of monooxygenase activity|glycosylceramide metabolic process|lysosome|negative regulation of nitric-oxide synthase activity|regulation of nitric-oxide synthase activity|glycosphingolipid catabolic process|alpha-galactosidase activity|ceramide catabolic process|raffinose alpha-galactosidase activity|glycosylceramide catabolic process K01189 alpha-galactosidase[3.2.1.22] hsa04142|hsa00561|hsa00600|hsa00052|hsa00603 Lysosome - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human)|Galactose metabolism - Homo sapiens (human)|Glycosphingolipid biosynthesis - globo series - Homo sapiens (human) X:101397803-101407925 1747 1898 1371 900 936 572 32.1648271844154 31.758844844878 22.7583046510386 14.8466537740213 14.1394325856285 9.86992230481053 28.8939922267773 12.9520028881534 1.15759433958768 7.25072999545051e-07 9.2505680890675e-06 UP ENSG00000139144 PIK3C2G phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma [Source:HGNC Symbol;Acc:HGNC:8973] GO:0040011|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0008289|GO:0071944|GO:0009605|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0044255|GO:0006935|GO:0043168|GO:0044281|GO:0005543|GO:0001882|GO:0016772|GO:0019637|GO:0005737|GO:0005942|GO:0006928|GO:0007154|GO:0006629|GO:0016477|GO:0007165|GO:0000166|GO:0044249|GO:0005829|GO:0008654|GO:0046486|GO:0035639|GO:0035091|GO:0001883|GO:0032549|GO:1990234|GO:0016301|GO:0006796|GO:0035556|GO:0008610|GO:0017076|GO:0030258|GO:0016773|GO:0006644|GO:0046474|GO:0035004|GO:0005524|GO:0030554|GO:0016310|GO:0048017|GO:0016307|GO:0046834|GO:0006650|GO:0016303|GO:0048015|GO:0046854|GO:0046488|GO:0006661|GO:0035005|GO:0036092|GO:0014065 locomotion|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|lipid binding|cell periphery|response to external stimulus|biosynthetic process|intracellular|protein binding|plasma membrane|protein complex|transferase activity|cellular lipid metabolic process|chemotaxis|anion binding|small molecule metabolic process|phospholipid binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|cytoplasm|phosphatidylinositol 3-kinase complex|movement of cell or subcellular component|cell communication|lipid metabolic process|cell migration|signal transduction|nucleotide binding|cellular biosynthetic process|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|phosphatidylinositol binding|purine nucleoside binding|ribonucleoside binding|transferase complex|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|lipid biosynthetic process|purine nucleotide binding|lipid modification|phosphotransferase activity, alcohol group as acceptor|phospholipid metabolic process|glycerophospholipid biosynthetic process|phosphatidylinositol 3-kinase activity|ATP binding|adenyl nucleotide binding|phosphorylation|inositol lipid-mediated signaling|phosphatidylinositol phosphate kinase activity|lipid phosphorylation|glycerophospholipid metabolic process|1-phosphatidylinositol-3-kinase activity|phosphatidylinositol-mediated signaling|phosphatidylinositol phosphorylation|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|1-phosphatidylinositol-4-phosphate 3-kinase activity|phosphatidylinositol-3-phosphate biosynthetic process|phosphatidylinositol 3-kinase signaling K00923 phosphatidylinositol-4-phosphate 3-kinase[2.7.1.154] hsa01100|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 12:18247614-18648416 1 0 9 20 38 31 0.0090924699245296 0 0.0737465108304706 0.162861741478177 0.283370513506676 0.264055013967733 0.0276129935850001 0.236762422984195 -3.10002091901257 7.25985872458923e-07 9.25825811037534e-06 DOWN ENSG00000176438 SYNE3 spectrin repeat containing, nuclear envelope family member 3 [Source:HGNC Symbol;Acc:HGNC:19861] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0044877|GO:0050794|GO:0043229|GO:0042175|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0019867|GO:0031224|GO:0005640|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0008360|GO:0051128|GO:0043231|GO:0051651|GO:0005737|GO:0005635|GO:0032403|GO:0045184|GO:0008104|GO:0061024|GO:0005783|GO:0008092|GO:0031965|GO:0048869|GO:0016021|GO:0006996|GO:0034993|GO:0000902|GO:0090150|GO:0007010|GO:0003779|GO:0005791|GO:0072657|GO:0032507|GO:0022604|GO:0090286|GO:0034613|GO:0051015|GO:0005634 developmental process|macromolecular complex|cell|membrane|cellular process|binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|outer membrane|intrinsic component of membrane|nuclear outer membrane|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of cell shape|regulation of cellular component organization|intracellular membrane-bounded organelle|maintenance of location in cell|cytoplasm|nuclear envelope|protein complex binding|establishment of protein localization|protein localization|membrane organization|endoplasmic reticulum|cytoskeletal protein binding|nuclear membrane|cellular developmental process|integral component of membrane|organelle organization|LINC complex|cell morphogenesis|establishment of protein localization to membrane|cytoskeleton organization|actin binding|rough endoplasmic reticulum|protein localization to membrane|maintenance of protein location in cell|regulation of cell morphogenesis|cytoskeletal anchoring at nuclear membrane|cellular protein localization|actin filament binding|nucleus - - - - 14:95407266-95475836 12 7 19 48 58 53 0.041892563604939 0.0222100152599001 0.0598010962720568 0.150133380481862 0.166126149443276 0.173398194024649 0.041301225045632 0.163219241316596 -1.98255466183318 7.28770989860177e-07 9.28980748560449e-06 DOWN ENSG00000144306 SCRN3 secernin 3 [Source:HGNC Symbol;Acc:HGNC:30382] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0071704|GO:0016787|GO:0006810|GO:0032940|GO:0008233|GO:0019538|GO:0016192|GO:0006887|GO:0006508|GO:0046903|GO:0008238|GO:0016805 cell|cellular process|metabolic process|catalytic activity|organic substance metabolic process|hydrolase activity|transport|secretion by cell|peptidase activity|protein metabolic process|vesicle-mediated transport|exocytosis|proteolysis|secretion|exopeptidase activity|dipeptidase activity - - - - 2:174395730-174429575 157 189 182 436 444 397 1.10295623596967 1.20670677501261 1.15277303819974 2.74437282385532 2.55923844173267 2.61384002405631 1.15414534972734 2.63915042988143 -1.19324866143374 7.29761563051056e-07 9.29846423530783e-06 DOWN ENSG00000153237 CCDC148 coiled-coil domain containing 148 [Source:HGNC Symbol;Acc:HGNC:25191] GO:0005488|GO:0005515 binding|protein binding - - - - 2:158171081-158456753 3 2 3 16 22 29 0.0289857715540759 0.0175600388088144 0.0261268481034241 0.138490784416459 0.174387860518349 0.262564622535514 0.0242242194887715 0.191814422490107 -2.98518911294326 7.32809516488117e-07 9.33331710974243e-06 DOWN ENSG00000138639 ARHGAP24 Rho GTPase activating protein 24 [Source:HGNC Symbol;Acc:HGNC:25361] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0030055|GO:0050794|GO:0043229|GO:0023051|GO:0009653|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0048514|GO:0001568|GO:0007275|GO:0005924|GO:0005912|GO:0005737|GO:0009966|GO:0010646|GO:0001525|GO:0007154|GO:0007165|GO:0048869|GO:0005829|GO:0001944|GO:0072358|GO:0035556|GO:0030154|GO:1902531|GO:0072359|GO:0005856|GO:0005925|GO:0051056|GO:0007264 developmental process|signaling|cell|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|cell-substrate junction|regulation of cellular process|intracellular organelle|regulation of signaling|anatomical structure morphogenesis|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|blood vessel development|multicellular organism development|cell-substrate adherens junction|adherens junction|cytoplasm|regulation of signal transduction|regulation of cell communication|angiogenesis|cell communication|signal transduction|cellular developmental process|cytosol|vasculature development|cardiovascular system development|intracellular signal transduction|cell differentiation|regulation of intracellular signal transduction|circulatory system development|cytoskeleton|focal adhesion|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 4:85475114-86002670 5 13 29 85 65 77 0.0283141967031119 0.0669040467247657 0.148057167285288 0.4312529759887 0.301991866411526 0.408632488379596 0.0810918035710552 0.380625776926607 -2.23074526263514 7.35993988408604e-07 9.36588428386636e-06 DOWN ENSG00000111877 MCM9 minichromosome maintenance 9 homologous recombination repair factor [Source:HGNC Symbol;Acc:HGNC:21484] GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0043227|GO:0032504|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048609|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0006139|GO:0007276|GO:0042555|GO:0000166|GO:0044249|GO:0003677|GO:0097362|GO:0034645|GO:0000725|GO:0035639|GO:0001883|GO:0006302|GO:0016818|GO:0032549|GO:0006259|GO:0017076|GO:0009059|GO:0007292|GO:0005634|GO:0006974|GO:0000724|GO:0006260|GO:0005524|GO:0030554|GO:0006310|GO:0016462|GO:0017111|GO:0004386 macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|membrane-bounded organelle|multicellular organism reproduction|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|multicellular organismal reproductive process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|gamete generation|MCM complex|nucleotide binding|cellular biosynthetic process|DNA binding|MCM8-MCM9 complex|cellular macromolecule biosynthetic process|recombinational repair|purine ribonucleoside triphosphate binding|purine nucleoside binding|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|DNA metabolic process|purine nucleotide binding|macromolecule biosynthetic process|female gamete generation|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|DNA replication|ATP binding|adenyl nucleotide binding|DNA recombination|pyrophosphatase activity|nucleoside-triphosphatase activity|helicase activity - - - - 6:118813442-118935162 54 69 39 197 231 140 0.201668928886944 0.23419324576916 0.1313188666752 0.65918437227011 0.707818670455208 0.490005973160729 0.189060347110435 0.619003005295349 -1.71109960487783 7.370270721426e-07 9.37104182783014e-06 DOWN ENSG00000172239 PAIP1 poly(A) binding protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16945] GO:0005623|GO:0045182|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0008494|GO:0006413|GO:0005737|GO:0006139|GO:0044249|GO:0019538|GO:0043487|GO:0031323|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0044265|GO:0010628|GO:0051247|GO:0032270|GO:0043603|GO:0044267|GO:0010467|GO:0031328|GO:0019439|GO:0051246|GO:0009059|GO:0016070|GO:0010557|GO:0043488|GO:0006401|GO:0043043|GO:0048255|GO:0045727|GO:0010608|GO:0006412|GO:0016071|GO:0006417|GO:0006402|GO:0000956|GO:0000289|GO:0000288 cell|translation regulator activity|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|translation activator activity|translational initiation|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of RNA stability|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|cellular macromolecule catabolic process|positive regulation of gene expression|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|regulation of mRNA stability|RNA catabolic process|peptide biosynthetic process|mRNA stabilization|positive regulation of translation|posttranscriptional regulation of gene expression|translation|mRNA metabolic process|regulation of translation|mRNA catabolic process|nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K14322 polyadenylate-binding protein-interacting protein 1[-] hsa03013 RNA transport - Homo sapiens (human) 5:43526267-43557758 3028 3207 2323 1503 1659 1276 32.1222507122643 30.9192638856474 22.2184428251388 14.2858703506845 14.4399126871556 12.686151639364 28.4199858076835 13.8039782257347 1.04182173093638 7.36754560672586e-07 9.37104182783014e-06 UP ENSG00000177042 TMEM80 transmembrane protein 80 [Source:HGNC Symbol;Acc:HGNC:27453] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 11:695428-705028 99 139 138 269 392 333 1.02142953706803 1.30337885263252 1.28371804703694 2.48671300268905 3.31840179479236 3.21993923046176 1.20284214557916 3.00835134264772 -1.32252574437755 7.48423934292392e-07 9.50785026994259e-06 DOWN ENSG00000114030 KPNA1 karyopherin alpha 1 [Source:HGNC Symbol;Acc:HGNC:6394] GO:0005215|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0033218|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:1903829|GO:0005515|GO:0012505|GO:0019222|GO:0016032|GO:0060341|GO:0042277|GO:0006725|GO:0008565|GO:0006810|GO:1901360|GO:0034641|GO:0097194|GO:0046483|GO:0043231|GO:0005737|GO:0032880|GO:0051222|GO:0005635|GO:0043005|GO:0045184|GO:0036477|GO:0032388|GO:0006139|GO:1900182|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0008219|GO:0090316|GO:0010033|GO:0031323|GO:0051701|GO:0019048|GO:0042307|GO:0005829|GO:0019054|GO:0007166|GO:0072594|GO:0034097|GO:0032386|GO:0051223|GO:0015031|GO:0044265|GO:0005048|GO:0070201|GO:0046907|GO:0031981|GO:0030425|GO:0005654|GO:0006259|GO:1904591|GO:0034613|GO:0012501|GO:0017038|GO:0019058|GO:0071310|GO:0019439|GO:0006921|GO:1903827|GO:0005634|GO:0006606|GO:0005643|GO:1904589|GO:0019221|GO:0033365|GO:0033157|GO:0030262|GO:0051169|GO:0075733|GO:0006607|GO:0006605|GO:0016482|GO:0006886|GO:0000018|GO:0006310|GO:0006308|GO:0071345|GO:0090305|GO:0042306|GO:1900180|GO:0008139|GO:0006915|GO:0046824|GO:1903533|GO:0006913|GO:0000737|GO:0034504|GO:0046822|GO:0006309|GO:0051170 transporter activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|amide binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|positive regulation of cellular protein localization|protein binding|endomembrane system|regulation of metabolic process|viral process|regulation of cellular localization|peptide binding|cellular aromatic compound metabolic process|protein transporter activity|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|execution phase of apoptosis|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|positive regulation of protein transport|nuclear envelope|neuron projection|establishment of protein localization|somatodendritic compartment|positive regulation of intracellular transport|nucleobase-containing compound metabolic process|positive regulation of protein localization to nucleus|protein localization|cell communication|signal transduction|establishment of localization in cell|cell death|positive regulation of intracellular protein transport|response to organic substance|regulation of cellular metabolic process|interaction with host|modulation by virus of host morphology or physiology|positive regulation of protein import into nucleus|cytosol|modulation by virus of host process|cell surface receptor signaling pathway|establishment of protein localization to organelle|response to cytokine|regulation of intracellular transport|regulation of protein transport|protein transport|cellular macromolecule catabolic process|signal sequence binding|regulation of establishment of protein localization|intracellular transport|nuclear lumen|dendrite|nucleoplasm|DNA metabolic process|positive regulation of protein import|cellular protein localization|programmed cell death|protein import|viral life cycle|cellular response to organic substance|aromatic compound catabolic process|cellular component disassembly involved in execution phase of apoptosis|regulation of cellular protein localization|nucleus|protein import into nucleus|nuclear pore|regulation of protein import|cytokine-mediated signaling pathway|protein localization to organelle|regulation of intracellular protein transport|apoptotic nuclear changes|nuclear transport|intracellular transport of virus|NLS-bearing protein import into nucleus|protein targeting|cytosolic transport|intracellular protein transport|regulation of DNA recombination|DNA recombination|DNA catabolic process|cellular response to cytokine stimulus|nucleic acid phosphodiester bond hydrolysis|regulation of protein import into nucleus|regulation of protein localization to nucleus|nuclear localization sequence binding|apoptotic process|positive regulation of nucleocytoplasmic transport|regulation of protein targeting|nucleocytoplasmic transport|DNA catabolic process, endonucleolytic|protein localization to nucleus|regulation of nucleocytoplasmic transport|apoptotic DNA fragmentation|nuclear import K15042 importin subunit alpha-1[-] hsa05164 Influenza A - Homo sapiens (human) 3:122421949-122514945 1013 1008 1044 2306 2627 1928 5.67081714501508 5.12833660533537 5.26927436114053 11.5662637708953 12.066021476397 10.1151467954521 5.35614270383033 11.2491440142481 -1.0705489219872 7.49897712185523e-07 9.52252075694879e-06 DOWN ENSG00000143353 LYPLAL1 lysophospholipase-like 1 [Source:HGNC Symbol;Acc:HGNC:20440] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0016788|GO:0031982|GO:0005737|GO:0098599|GO:0070062|GO:0019538|GO:0005829|GO:0043412|GO:0030163|GO:0036211|GO:0016790|GO:0042157|GO:0008474|GO:0016298|GO:0044267|GO:0052689|GO:0004620|GO:0004622|GO:0042159|GO:0006464|GO:0098734|GO:0002084 cell|cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|hydrolase activity, acting on ester bonds|vesicle|cytoplasm|palmitoyl hydrolase activity|extracellular exosome|protein metabolic process|cytosol|macromolecule modification|protein catabolic process|protein modification process|thiolester hydrolase activity|lipoprotein metabolic process|palmitoyl-(protein) hydrolase activity|lipase activity|cellular protein metabolic process|carboxylic ester hydrolase activity|phospholipase activity|lysophospholipase activity|lipoprotein catabolic process|cellular protein modification process|macromolecule depalmitoylation|protein depalmitoylation - - - - 1:219173844-219212865 126 130 169 352 493 298 1.90771115093369 1.78881619654945 2.30697568918081 4.77510502976483 6.12431321741502 4.22851459949145 2.00116767888798 5.04264428222377 -1.33333840193444 7.63204020786938e-07 9.68736940330495e-06 DOWN ENSG00000278259 MYO19 myosin XIX [Source:HGNC Symbol;Acc:HGNC:26234] GO:0032991|GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0019867|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005737|GO:0031966|GO:0016459|GO:0008092|GO:0000166|GO:0005740|GO:0035639|GO:0005741|GO:0017022|GO:0001883|GO:0003779|GO:0016818|GO:0032549|GO:0005739|GO:0017076|GO:0005856|GO:0015629|GO:0005524|GO:0030554|GO:0016462|GO:0032027|GO:0017111|GO:0016887|GO:0003774|GO:0000146|GO:0060002 macromolecular complex|cell|membrane|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|outer membrane|hydrolase activity|intracellular|protein binding|protein complex|organelle membrane|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|myosin complex|cytoskeletal protein binding|nucleotide binding|mitochondrial envelope|purine ribonucleoside triphosphate binding|mitochondrial outer membrane|myosin binding|purine nucleoside binding|actin binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|mitochondrion|purine nucleotide binding|cytoskeleton|actin cytoskeleton|ATP binding|adenyl nucleotide binding|pyrophosphatase activity|myosin light chain binding|nucleoside-triphosphatase activity|ATPase activity|motor activity|microfilament motor activity|plus-end directed microfilament motor activity - - - - 17:36495633-36543435 624 816 731 1683 1953 1350 1.85282279180082 2.202010634506 1.95695425282514 4.47745255670244 4.75794590506815 3.75674635533868 2.00392922637732 4.33071493903642 -1.11177365575325 7.68612434664274e-07 9.75187234358999e-06 DOWN ENSG00000104689 TNFRSF10A tumor necrosis factor receptor superfamily member 10a [Source:HGNC Symbol;Acc:HGNC:11904] GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0009628|GO:0009986|GO:0044237|GO:0038023|GO:0023051|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0042127|GO:0009612|GO:0010941|GO:0007275|GO:0006952|GO:0031325|GO:0010942|GO:0005887|GO:0019899|GO:0004888|GO:0045569|GO:0009966|GO:0060548|GO:0010646|GO:0031226|GO:0043085|GO:0009617|GO:0007154|GO:0044092|GO:0007165|GO:0008134|GO:0008219|GO:0050790|GO:0043086|GO:0016021|GO:0009967|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:1902533|GO:2001235|GO:0032268|GO:0007166|GO:0033993|GO:0043412|GO:0034097|GO:0051345|GO:0002237|GO:0043069|GO:0051604|GO:0005035|GO:0051347|GO:0036211|GO:0032269|GO:0006954|GO:0010939|GO:0002020|GO:0051247|GO:0051346|GO:0006508|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0051246|GO:0071260|GO:0043068|GO:1902531|GO:0032496|GO:0043067|GO:0097190|GO:0010466|GO:0019221|GO:0005031|GO:0031401|GO:0043065|GO:0016485|GO:0097296|GO:0038061|GO:0030162|GO:0045862|GO:2001236|GO:0016310|GO:0052547|GO:0097300|GO:1901222|GO:2001269|GO:0042981|GO:0071345|GO:0045861|GO:0043066|GO:0034612|GO:0006464|GO:0010952|GO:0097191|GO:0043549|GO:0006915|GO:1901224|GO:0033674|GO:0045859|GO:0010950|GO:0045860|GO:0043281|GO:0006468|GO:0071356|GO:0042325|GO:0001932|GO:0007250|GO:0070266|GO:0010951|GO:0033209|GO:0031638|GO:0043280|GO:0001934|GO:0006919|GO:0043154|GO:0042327|GO:0008625|GO:1902041|GO:0052548|GO:2000117|GO:2001056|GO:0071902|GO:0071900|GO:2000116|GO:0097202|GO:0032147|GO:0036462 developmental process|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|organic substance metabolic process|immune response|response to abiotic stimulus|cell surface|cellular metabolic process|signaling receptor activity|regulation of signaling|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|response to mechanical stimulus|regulation of cell death|multicellular organism development|defense response|positive regulation of cellular metabolic process|positive regulation of cell death|integral component of plasma membrane|enzyme binding|transmembrane signaling receptor activity|TRAIL binding|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|response to bacterium|cell communication|negative regulation of molecular function|signal transduction|transcription factor binding|cell death|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|positive regulation of signal transduction|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cell surface receptor signaling pathway|response to lipid|macromolecule modification|response to cytokine|positive regulation of hydrolase activity|response to molecule of bacterial origin|negative regulation of programmed cell death|protein maturation|death receptor activity|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|inflammatory response|regulation of necrotic cell death|protease binding|positive regulation of protein metabolic process|negative regulation of hydrolase activity|proteolysis|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|regulation of protein metabolic process|cellular response to mechanical stimulus|positive regulation of programmed cell death|regulation of intracellular signal transduction|response to lipopolysaccharide|regulation of programmed cell death|apoptotic signaling pathway|negative regulation of peptidase activity|cytokine-mediated signaling pathway|tumor necrosis factor-activated receptor activity|positive regulation of protein modification process|positive regulation of apoptotic process|protein processing|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|NIK/NF-kappaB signaling|regulation of proteolysis|positive regulation of proteolysis|regulation of extrinsic apoptotic signaling pathway|phosphorylation|regulation of peptidase activity|programmed necrotic cell death|regulation of NIK/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of proteolysis|negative regulation of apoptotic process|response to tumor necrosis factor|cellular protein modification process|positive regulation of peptidase activity|extrinsic apoptotic signaling pathway|regulation of kinase activity|apoptotic process|positive regulation of NIK/NF-kappaB signaling|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of endopeptidase activity|positive regulation of protein kinase activity|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|cellular response to tumor necrosis factor|regulation of phosphorylation|regulation of protein phosphorylation|activation of NF-kappaB-inducing kinase activity|necroptotic process|negative regulation of endopeptidase activity|tumor necrosis factor-mediated signaling pathway|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of phosphorylation|extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of endopeptidase activity|negative regulation of cysteine-type endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|activation of protein kinase activity|TRAIL-activated apoptotic signaling pathway K04722 tumor necrosis factor receptor superfamily member 10[-] hsa04060|hsa05164|hsa04210|hsa05162|hsa04650 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Measles - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human) 8:23190452-23225126 773 865 595 367 424 250 15.0549546270551 15.3107399703658 10.4479551450758 6.40417715557758 6.77537783284985 4.56320260103017 13.6045499141656 5.9142525298192 1.20182147718026 7.69420176993887e-07 9.75797364654864e-06 UP ENSG00000101294 HM13 histocompatibility (minor) 13 [Source:HGNC Symbol;Acc:HGNC:16435] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0009986|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0042802|GO:0098554|GO:0036513|GO:0006810|GO:0033554|GO:0022607|GO:0043231|GO:0031227|GO:0008233|GO:0019899|GO:0005737|GO:0098562|GO:0046983|GO:0045184|GO:0030176|GO:0008104|GO:0005783|GO:0051649|GO:0016021|GO:0019538|GO:0031301|GO:0010033|GO:0036503|GO:0030163|GO:0030970|GO:0071556|GO:0015031|GO:0046907|GO:0005791|GO:0071458|GO:0006508|GO:0006461|GO:0034613|GO:0034976|GO:0042803|GO:0044389|GO:0031625|GO:0051259|GO:0032527|GO:0033619|GO:0006886|GO:0070001|GO:0004175|GO:1904211|GO:0004190|GO:0051260|GO:0051262|GO:0042500|GO:0051289 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cell surface|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|identical protein binding|cytoplasmic side of endoplasmic reticulum membrane|Derlin-1 retrotranslocation complex|transport|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|peptidase activity|enzyme binding|cytoplasm|cytoplasmic side of membrane|protein dimerization activity|establishment of protein localization|integral component of endoplasmic reticulum membrane|protein localization|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|protein metabolic process|integral component of organelle membrane|response to organic substance|ERAD pathway|protein catabolic process|retrograde protein transport, ER to cytosol|integral component of lumenal side of endoplasmic reticulum membrane|protein transport|intracellular transport|rough endoplasmic reticulum|integral component of cytoplasmic side of endoplasmic reticulum membrane|proteolysis|protein complex assembly|cellular protein localization|response to endoplasmic reticulum stress|protein homodimerization activity|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|protein oligomerization|protein exit from endoplasmic reticulum|membrane protein proteolysis|intracellular protein transport|aspartic-type peptidase activity|endopeptidase activity|membrane protein proteolysis involved in retrograde protein transport, ER to cytosol|aspartic-type endopeptidase activity|protein homooligomerization|protein tetramerization|aspartic endopeptidase activity, intramembrane cleaving|protein homotetramerization - - - - 20:31514428-31577923 1116 1246 1376 2486 2856 2601 4.79659135996729 4.86706161679135 5.33213817617272 9.57342798450549 10.0715172317641 10.4770246913245 4.99859705097712 10.0406566358647 -1.0062584836358 7.70286637949173e-07 9.76481413559856e-06 DOWN ENSG00000170430 MGMT O-6-methylguanine-DNA methyltransferase [Source:HGNC Symbol;Acc:HGNC:7059] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0009605|GO:0009893|GO:0005622|GO:0016740|GO:0048856|GO:0019222|GO:0006281|GO:0006725|GO:0009888|GO:0009314|GO:1901360|GO:2001022|GO:0010941|GO:0009991|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0010243|GO:0006979|GO:0060548|GO:0042493|GO:0006139|GO:0008219|GO:0050790|GO:0048869|GO:0019538|GO:0010033|GO:0031323|GO:0048732|GO:0009636|GO:0007584|GO:0003677|GO:0008168|GO:0030879|GO:0046872|GO:0043412|GO:0043200|GO:0006306|GO:0033273|GO:0045739|GO:0031981|GO:2001020|GO:0034599|GO:0071478|GO:0006508|GO:0005654|GO:0006259|GO:0006282|GO:0012501|GO:0014070|GO:0060429|GO:0051054|GO:0010212|GO:0071310|GO:0051246|GO:0030154|GO:0031667|GO:0005634|GO:0043067|GO:0097305|GO:0006974|GO:0006307|GO:0030855|GO:0030162|GO:0052547|GO:0005509|GO:0071407|GO:0006304|GO:0045471|GO:0003684|GO:0006266|GO:0042981|GO:0071479|GO:0061180|GO:0009008|GO:0006915|GO:0051593|GO:0060644|GO:0043281|GO:0003908|GO:0052548|GO:2000116 developmental process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|methylation|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|intracellular|transferase activity|anatomical structure development|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|tissue development|response to radiation|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|regulation of cell death|response to extracellular stimulus|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|response to oxidative stress|negative regulation of cell death|response to drug|nucleobase-containing compound metabolic process|cell death|regulation of catalytic activity|cellular developmental process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|gland development|response to toxic substance|response to nutrient|DNA binding|methyltransferase activity|mammary gland development|metal ion binding|macromolecule modification|response to amino acid|DNA methylation|response to vitamin|positive regulation of DNA repair|nuclear lumen|regulation of response to DNA damage stimulus|cellular response to oxidative stress|cellular response to radiation|proteolysis|nucleoplasm|DNA metabolic process|regulation of DNA repair|programmed cell death|response to organic cyclic compound|epithelium development|positive regulation of DNA metabolic process|response to ionizing radiation|cellular response to organic substance|regulation of protein metabolic process|cell differentiation|response to nutrient levels|nucleus|regulation of programmed cell death|response to alcohol|cellular response to DNA damage stimulus|DNA dealkylation involved in DNA repair|epithelial cell differentiation|regulation of proteolysis|regulation of peptidase activity|calcium ion binding|cellular response to organic cyclic compound|DNA modification|response to ethanol|damaged DNA binding|DNA ligation|regulation of apoptotic process|cellular response to ionizing radiation|mammary gland epithelium development|DNA-methyltransferase activity|apoptotic process|response to folic acid|mammary gland epithelial cell differentiation|regulation of cysteine-type endopeptidase activity involved in apoptotic process|methylated-DNA-[protein]-cysteine S-methyltransferase activity|regulation of endopeptidase activity|regulation of cysteine-type endopeptidase activity - - - - 10:129467184-129768007 130 137 143 349 378 303 2.42184902527123 2.31956565959715 2.40190355972925 5.82543592318852 5.77783151093208 5.29026058795445 2.38110608153254 5.63117600735835 -1.24180434821965 7.717318633831e-07 9.77898261860741e-06 DOWN ENSG00000092758 COL9A3 collagen, type IX, alpha 3 [Source:HGNC Symbol;Acc:HGNC:2219] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0000003|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005201|GO:0043229|GO:0005578|GO:0044702|GO:0071704|GO:0009056|GO:0003006|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0005622|GO:0043234|GO:0012505|GO:0048856|GO:0045137|GO:0006935|GO:0048468|GO:0007275|GO:0048513|GO:0043062|GO:0043231|GO:0048608|GO:0005737|GO:0006928|GO:0007548|GO:0044236|GO:0008406|GO:0030020|GO:0005783|GO:0030030|GO:0048869|GO:0005581|GO:0000902|GO:0031175|GO:0030574|GO:0044259|GO:0008584|GO:0008585|GO:0022617|GO:0046661|GO:0061458|GO:0000904|GO:0046545|GO:0032990|GO:0005788|GO:0007399|GO:0097485|GO:0030198|GO:0030154|GO:0048858|GO:0046546|GO:0048666|GO:0030182|GO:0007411|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0005594|GO:0032963|GO:0007409|GO:0048699 locomotion|developmental process|extracellular matrix|macromolecular complex|reproduction|structural molecule activity|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|extracellular matrix structural constituent|intracellular organelle|proteinaceous extracellular matrix|single organism reproductive process|organic substance metabolic process|catabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|intracellular|protein complex|endomembrane system|anatomical structure development|development of primary sexual characteristics|chemotaxis|cell development|multicellular organism development|animal organ development|extracellular structure organization|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|movement of cell or subcellular component|sex differentiation|multicellular organism metabolic process|gonad development|extracellular matrix structural constituent conferring tensile strength|endoplasmic reticulum|cell projection organization|cellular developmental process|collagen trimer|cell morphogenesis|neuron projection development|collagen catabolic process|multicellular organismal macromolecule metabolic process|male gonad development|female gonad development|extracellular matrix disassembly|male sex differentiation|reproductive system development|cell morphogenesis involved in differentiation|development of primary female sexual characteristics|cell part morphogenesis|endoplasmic reticulum lumen|nervous system development|neuron projection guidance|extracellular matrix organization|cell differentiation|cell projection morphogenesis|development of primary male sexual characteristics|neuron development|neuron differentiation|axon guidance|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|collagen type IX trimer|collagen metabolic process|axonogenesis|generation of neurons K08131 collagen, type IX, alpha[-] hsa04151|hsa04510|hsa04974|hsa04512 PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 20:62816244-62841159 416 454 448 202 255 229 3.30375588485051 3.27680431045394 3.20779533654839 1.43735078018371 1.66158411200485 1.70442793799913 3.26278517728428 1.6011209433959 1.02702171470375 7.74781307201795e-07 9.81345827119321e-06 UP ENSG00000161847 RAVER1 ribonucleoprotein, PTB-binding 1 [Source:HGNC Symbol;Acc:HGNC:30296] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0000166|GO:0003723|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0016071|GO:0044822|GO:0006397|GO:0008380|GO:0000375|GO:0000398 cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nucleotide binding|RNA binding|gene expression|RNA metabolic process|nucleus|RNA processing|mRNA metabolic process|poly(A) RNA binding|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 19:10316212-10333640 2560 2375 2381 1462 931 1261 16.9810892993073 14.317568961965 14.2396446246369 8.68901582134303 5.06691281133814 7.83916278292502 15.1794342953031 7.19836380520206 1.07637710262602 7.80533164710206e-07 9.88211921088146e-06 UP ENSG00000146223 RPL7L1 ribosomal protein L7 like 1 [Source:HGNC Symbol;Acc:HGNC:21370] GO:0032502|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0048646|GO:0001824|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0001825|GO:0043231|GO:0005737|GO:0030529|GO:0006139|GO:0044249|GO:0022613|GO:0019538|GO:0005730|GO:0005829|GO:0034645|GO:0006518|GO:0003723|GO:0005840|GO:0009790|GO:0042254|GO:0031981|GO:0015934|GO:0043603|GO:0044267|GO:0010467|GO:0042273|GO:0009059|GO:0016070|GO:0005634|GO:0006364|GO:0043043|GO:0009792|GO:0006396|GO:0034660|GO:0022626|GO:0006412|GO:0000470|GO:0022625|GO:0044822|GO:0016072|GO:0043009|GO:0000463|GO:0002181|GO:0001701 developmental process|macromolecular complex|structural molecule activity|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|blastocyst development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|blastocyst formation|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|nucleolus|cytosol|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|ribosome|embryo development|ribosome biogenesis|nuclear lumen|large ribosomal subunit|cellular amide metabolic process|cellular protein metabolic process|gene expression|ribosomal large subunit biogenesis|macromolecule biosynthetic process|RNA metabolic process|nucleus|rRNA processing|peptide biosynthetic process|embryo development ending in birth or egg hatching|RNA processing|ncRNA metabolic process|cytosolic ribosome|translation|maturation of LSU-rRNA|cytosolic large ribosomal subunit|poly(A) RNA binding|rRNA metabolic process|chordate embryonic development|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|cytoplasmic translation|in utero embryonic development - - - - 6:42879618-42889925 6588 6926 4273 2930 3204 2241 34.0131654647691 32.4979536305958 19.8902640305294 13.5537270676042 13.5723170277635 10.8433721867253 28.8004610419648 12.656472094031 1.18621658740343 7.84885498934298e-07 9.93301046425796e-06 UP ENSG00000169084 DHRSX dehydrogenase/reductase (SDR family) X-linked [Source:HGNC Symbol;Acc:HGNC:18399] GO:0008152|GO:0003824|GO:0016491|GO:0055114 metabolic process|catalytic activity|oxidoreductase activity|oxidation-reduction process - - - - X:2219516-2502805 83 91 109 279 265 212 1.21330520747422 1.20896361104633 1.4365862361557 3.65419482419765 3.17836938955879 2.90438953065433 1.28628501822542 3.24565124813692 -1.33529763364721 7.88169693888618e-07 9.96612369392241e-06 DOWN ENSG00000198912 C1orf174 chromosome 1 open reading frame 174 [Source:HGNC Symbol;Acc:HGNC:27915] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|nucleus - - - - 1:3889125-3900293 548 518 571 292 327 243 7.48191112549984 6.42750112454617 7.02881679965146 3.57200690582422 3.66309212698005 3.10933818037969 6.97940968323249 3.44814573772799 1.01728426680563 7.91716909433757e-07 1.00025038570611e-05 UP ENSG00000227954 TARID TCF21 antisense RNA inducing promoter demethylation [Source:HGNC Symbol;Acc:HGNC:50506] - - - - - - 6:133502252-133892802 0 0 0 6 9 12 0 0 0 0.0389596471305203 0.0535126076081794 0.081497742166071 0 0.0579899989682569 -Inf 7.91669470399144e-07 1.00025038570611e-05 DOWN ENSG00000168243 GNG4 guanine nucleotide binding protein (G protein), gamma 4 [Source:HGNC Symbol;Acc:HGNC:4407] GO:0040007|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0019898|GO:0048523|GO:0050794|GO:0016049|GO:0044237|GO:0023051|GO:0045926|GO:0016043|GO:0043227|GO:0071944|GO:0040008|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0009898|GO:0098797|GO:0015980|GO:0044281|GO:0031982|GO:0051128|GO:0010243|GO:0030308|GO:0007267|GO:0031234|GO:0098562|GO:0009966|GO:0019897|GO:0010646|GO:0007154|GO:0007165|GO:0070062|GO:0009725|GO:0005834|GO:0006091|GO:0010033|GO:0001558|GO:0055114|GO:0007186|GO:0008277|GO:1901652|GO:0071417|GO:0043434|GO:0006112|GO:0071310|GO:0032870|GO:1901653|GO:0071375|GO:0033762|GO:0071377|GO:0007268 growth|macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|negative regulation of cellular process|regulation of cellular process|cell growth|cellular metabolic process|regulation of signaling|negative regulation of growth|cellular component organization|membrane-bounded organelle|cell periphery|regulation of growth|intracellular|protein binding|plasma membrane|protein complex|cytoplasmic side of plasma membrane|plasma membrane protein complex|energy derivation by oxidation of organic compounds|small molecule metabolic process|vesicle|regulation of cellular component organization|response to organonitrogen compound|negative regulation of cell growth|cell-cell signaling|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|regulation of signal transduction|extrinsic component of plasma membrane|regulation of cell communication|cell communication|signal transduction|extracellular exosome|response to hormone|heterotrimeric G-protein complex|generation of precursor metabolites and energy|response to organic substance|regulation of cell growth|oxidation-reduction process|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|response to peptide|cellular response to organonitrogen compound|response to peptide hormone|energy reserve metabolic process|cellular response to organic substance|cellular response to hormone stimulus|cellular response to peptide|cellular response to peptide hormone stimulus|response to glucagon|cellular response to glucagon stimulus|synaptic transmission K04541 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4[-] hsa05200|hsa04151|hsa04014|hsa04062|hsa05034|hsa04728|hsa04724|hsa04726|hsa04725|hsa04723|hsa04713|hsa05032|hsa04727 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human) 1:235547687-235650754 318 237 413 672 907 801 3.05173425487707 2.06703581839606 3.57341400311063 5.77811997708967 7.1415848557285 7.20412171195772 2.89739469212792 6.70794218159196 -1.21111402738977 7.95806837692214e-07 1.00499227294684e-05 DOWN ENSG00000197885 NKIRAS1 NFKB inhibitor interacting Ras-like 1 [Source:HGNC Symbol;Acc:HGNC:17899] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0016787|GO:0005622|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0000166|GO:0035639|GO:0001883|GO:0015031|GO:0016818|GO:0032549|GO:0035556|GO:0017076|GO:0032561|GO:0007249|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0017111|GO:0003924 signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|hydrolase activity|intracellular|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|I-kappaB kinase/NF-kappaB signaling|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|GTPase activity - - - - 3:23891660-23946591 366 439 379 179 234 176 1.96625478363398 2.14340062560715 1.83574448222024 0.861610083273119 1.03143654579602 0.886137467778296 1.98179996382046 0.926394698949145 1.09711244610037 8.00717542873734e-07 1.01076623784154e-05 UP ENSG00000264538 SUZ12P1 SUZ12 polycomb repressive complex 2 subunit pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:32421] - - - - - - 17:30709299-30790908 29 35 40 105 102 107 0.419847056266912 0.460516986783729 0.522115295029636 1.36200677649928 1.21160292145945 1.45179931910992 0.467493112693426 1.34180300568955 -1.52115586462281 8.01977386175409e-07 1.01192869344381e-05 DOWN ENSG00000057704 TMCC3 transmembrane and coiled-coil domain family 3 [Source:HGNC Symbol;Acc:HGNC:29199] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 12:94567124-94650562 84 87 146 257 298 314 0.580545611279087 0.546460743091052 0.909753649057667 1.59143469615575 1.68982924157045 2.03383812099349 0.678920001142602 1.7717006862399 -1.38382140022454 8.06987196275162e-07 1.01781984611739e-05 DOWN ENSG00000230311 TOMM20P4 TOMM20 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:50522] - - - - - - X:73223124-73223558 247 338 197 93 128 92 40.1655593334666 49.9519726499436 28.8827031626684 13.5498732843528 17.0779228887489 14.0208373770218 39.6667450486929 14.8828778500412 1.41427649617153 8.08138106373085e-07 1.01884100623573e-05 UP ENSG00000256594 RP11-705C15.2 - - - - - - - 12:9617284-9658412 50 47 69 164 142 181 0.660962562008232 0.564667094444802 0.822385622358928 1.9424666859392 1.54016686875222 2.24242212018789 0.682671759603987 1.90835189162644 -1.48306324484433 8.09795581724327e-07 1.02049967483318e-05 DOWN ENSG00000144659 SLC25A38 solute carrier family 25 member 38 [Source:HGNC Symbol;Acc:HGNC:26054] GO:0032502|GO:0005215|GO:0002376|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003735|GO:0043227|GO:0002262|GO:0009058|GO:0031224|GO:0005622|GO:0002520|GO:0048856|GO:0031090|GO:0006725|GO:0019866|GO:0006810|GO:1901360|GO:0007275|GO:0048513|GO:0034101|GO:0034641|GO:0046483|GO:0043231|GO:0042168|GO:0005737|GO:0042592|GO:0031966|GO:0051186|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0005740|GO:0034645|GO:0030218|GO:0006518|GO:0030097|GO:0006778|GO:0048872|GO:0005743|GO:0006783|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0030154|GO:0006779|GO:0043043|GO:0033014|GO:0006412|GO:0030099 developmental process|transporter activity|immune system process|structural molecule activity|cell|membrane|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|myeloid cell homeostasis|biosynthetic process|intrinsic component of membrane|intracellular|immune system development|anatomical structure development|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|transport|organic cyclic compound metabolic process|multicellular organism development|animal organ development|erythrocyte homeostasis|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|heme metabolic process|cytoplasm|homeostatic process|mitochondrial membrane|cofactor metabolic process|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|mitochondrial envelope|cellular macromolecule biosynthetic process|erythrocyte differentiation|peptide metabolic process|hemopoiesis|porphyrin-containing compound metabolic process|homeostasis of number of cells|mitochondrial inner membrane|heme biosynthetic process|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|porphyrin-containing compound biosynthetic process|peptide biosynthetic process|tetrapyrrole biosynthetic process|translation|myeloid cell differentiation - - - - 3:39383348-39397351 685 753 587 347 402 307 18.9572678490728 18.9391352658501 14.6466152859709 8.60423258808025 9.1280760937184 7.96254398825271 17.5143394669646 8.56495089001712 1.03201970031704 8.10691801135047e-07 1.02119801818927e-05 UP ENSG00000203883 SOX18 SRY-box 18 [Source:HGNC Symbol;Acc:HGNC:11194] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0048870|GO:0009653|GO:0000785|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0001946|GO:0007507|GO:0042127|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:1901360|GO:0001568|GO:0007275|GO:0003676|GO:0048513|GO:0001945|GO:0034641|GO:0003157|GO:0031325|GO:0046483|GO:0043231|GO:0001942|GO:0000981|GO:0007389|GO:0006928|GO:0009887|GO:0005667|GO:0048729|GO:0046983|GO:0048598|GO:0048568|GO:0009890|GO:0060214|GO:0006139|GO:0001525|GO:0000790|GO:0016477|GO:0003151|GO:0036303|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0072089|GO:0000982|GO:0003677|GO:0003143|GO:0010468|GO:0090132|GO:0034645|GO:0002009|GO:0044798|GO:0001944|GO:0072358|GO:0010629|GO:0002064|GO:0022405|GO:0046982|GO:0051252|GO:0035050|GO:0035051|GO:0003007|GO:0009790|GO:0010628|GO:0001667|GO:0031981|GO:0001708|GO:0001570|GO:0061371|GO:0005694|GO:0000228|GO:0043588|GO:0060429|GO:0010467|GO:0048562|GO:0060562|GO:0060956|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0048469|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0060836|GO:0045165|GO:0072091|GO:0003160|GO:0042633|GO:0003158|GO:0000975|GO:0045893|GO:0048863|GO:0001885|GO:0009792|GO:0030855|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:1902679|GO:0008544|GO:0003690|GO:0001947|GO:0009855|GO:0048866|GO:0010631|GO:0006351|GO:0006355|GO:0098773|GO:0009299|GO:0061028|GO:0045944|GO:0045446|GO:0006366|GO:1903507|GO:0006357|GO:0007368|GO:1903506|GO:0044212|GO:0043009|GO:0000122|GO:0043542|GO:0042789|GO:0000976|GO:0001012|GO:0001701|GO:0001159|GO:0043534|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell motility|anatomical structure morphogenesis|chromatin|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|lymphangiogenesis|heart development|regulation of cell proliferation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|tube development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|nucleic acid binding|animal organ development|lymph vessel development|cellular nitrogen compound metabolic process|endocardium development|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|hair follicle development|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|movement of cell or subcellular component|organ morphogenesis|transcription factor complex|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|endocardium formation|nucleobase-containing compound metabolic process|angiogenesis|nuclear chromatin|cell migration|outflow tract morphogenesis|lymph vessel morphogenesis|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|stem cell proliferation|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|embryonic heart tube morphogenesis|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|morphogenesis of an epithelium|nuclear transcription factor complex|vasculature development|cardiovascular system development|negative regulation of gene expression|epithelial cell development|hair cycle process|protein heterodimerization activity|regulation of RNA metabolic process|embryonic heart tube development|cardiocyte differentiation|heart morphogenesis|embryo development|positive regulation of gene expression|ameboidal-type cell migration|nuclear lumen|cell fate specification|vasculogenesis|determination of heart left/right asymmetry|chromosome|nuclear chromosome|skin development|epithelium development|gene expression|embryonic organ morphogenesis|epithelial tube morphogenesis|endocardial cell differentiation|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|cell maturation|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|lymphatic endothelial cell differentiation|cell fate commitment|regulation of stem cell proliferation|endocardium morphogenesis|hair cycle|endothelium development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|stem cell differentiation|endothelial cell development|embryo development ending in birth or egg hatching|epithelial cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of RNA biosynthetic process|epidermis development|double-stranded DNA binding|heart looping|determination of bilateral symmetry|stem cell fate specification|epithelial cell migration|transcription, DNA-templated|regulation of transcription, DNA-templated|skin epidermis development|mRNA transcription|establishment of endothelial barrier|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|determination of left/right symmetry|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|endothelial cell migration|mRNA transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|core promoter proximal region DNA binding|blood vessel endothelial cell migration|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 20:64047582-64049641 14 26 18 1 1 6 0.53129621363906 0.896711295094317 0.615882476363113 0.0339854042386331 0.0311498002061977 0.213403964064759 0.68129666169883 0.0928463895031966 2.87536542308428 8.19223499335553e-07 1.03150984180361e-05 UP ENSG00000112294 ALDH5A1 aldehyde dehydrogenase 5 family member A1 [Source:HGNC Symbol;Acc:HGNC:408] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0048037|GO:0005622|GO:0007269|GO:0005515|GO:0048856|GO:0042802|GO:0006575|GO:0044255|GO:0042133|GO:0009791|GO:0006810|GO:0006082|GO:0007275|GO:0034641|GO:0043168|GO:0015980|GO:0044281|GO:0032940|GO:0019637|GO:0022607|GO:0043231|GO:0005737|GO:0006520|GO:0007267|GO:0005975|GO:0043177|GO:0046983|GO:0016903|GO:0007154|GO:0006629|GO:0051649|GO:0050662|GO:0001505|GO:0000166|GO:0006091|GO:0022900|GO:0006790|GO:0055114|GO:0006836|GO:0006665|GO:0046486|GO:0006518|GO:0042135|GO:0007417|GO:0006631|GO:0006643|GO:0022904|GO:0016620|GO:0009063|GO:0005996|GO:0006749|GO:0005759|GO:0005739|GO:0006461|GO:0006796|GO:0043603|GO:0031406|GO:0007399|GO:0046903|GO:0045333|GO:0042803|GO:0051287|GO:0006644|GO:0009448|GO:0019318|GO:0006672|GO:0004029|GO:0006687|GO:0051259|GO:0009013|GO:0046395|GO:0046459|GO:0004777|GO:0006664|GO:0019752|GO:0009450|GO:0006650|GO:0006677|GO:0006541|GO:0043648|GO:0006006|GO:0032787|GO:0051260|GO:0051262|GO:0007268|GO:0006536|GO:0051289|GO:0006083|GO:0006105|GO:0006678|GO:0006681 developmental process|signaling|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|cofactor binding|intracellular|neurotransmitter secretion|protein binding|anatomical structure development|identical protein binding|cellular modified amino acid metabolic process|cellular lipid metabolic process|neurotransmitter metabolic process|post-embryonic development|transport|organic acid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|organophosphate metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|cell-cell signaling|carbohydrate metabolic process|organic acid binding|protein dimerization activity|oxidoreductase activity, acting on the aldehyde or oxo group of donors|cell communication|lipid metabolic process|establishment of localization in cell|coenzyme binding|regulation of neurotransmitter levels|nucleotide binding|generation of precursor metabolites and energy|electron transport chain|sulfur compound metabolic process|oxidation-reduction process|neurotransmitter transport|sphingolipid metabolic process|glycerolipid metabolic process|peptide metabolic process|neurotransmitter catabolic process|central nervous system development|fatty acid metabolic process|membrane lipid metabolic process|respiratory electron transport chain|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|cellular amino acid catabolic process|monosaccharide metabolic process|glutathione metabolic process|mitochondrial matrix|mitochondrion|protein complex assembly|phosphate-containing compound metabolic process|cellular amide metabolic process|carboxylic acid binding|nervous system development|secretion|cellular respiration|protein homodimerization activity|NAD binding|phospholipid metabolic process|gamma-aminobutyric acid metabolic process|hexose metabolic process|ceramide metabolic process|aldehyde dehydrogenase (NAD) activity|glycosphingolipid metabolic process|protein oligomerization|succinate-semialdehyde dehydrogenase [NAD(P)+] activity|carboxylic acid catabolic process|short-chain fatty acid metabolic process|succinate-semialdehyde dehydrogenase (NAD+) activity|glycolipid metabolic process|carboxylic acid metabolic process|gamma-aminobutyric acid catabolic process|glycerophospholipid metabolic process|glycosylceramide metabolic process|glutamine metabolic process|dicarboxylic acid metabolic process|glucose metabolic process|monocarboxylic acid metabolic process|protein homooligomerization|protein tetramerization|synaptic transmission|glutamate metabolic process|protein homotetramerization|acetate metabolic process|succinate metabolic process|glucosylceramide metabolic process|galactosylceramide metabolic process K00139 succinate-semialdehyde dehydrogenase[1.2.1.24] hsa01100|hsa00250|hsa00650 Metabolic pathways - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human)|Butanoate metabolism - Homo sapiens (human) 6:24494852-24537207 266 392 451 851 807 864 2.21104455188573 2.96130238123513 3.37992172085192 6.33787052871599 5.50373659590407 6.73067881491062 2.85075621799093 6.19076197984356 -1.11877231944399 8.19645963128399e-07 1.03160668563386e-05 DOWN ENSG00000154127 UBASH3B ubiquitin associated and SH3 domain containing B [Source:HGNC Symbol;Acc:HGNC:29884] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0007155|GO:0043227|GO:0009605|GO:0023057|GO:0016787|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:1903706|GO:0051282|GO:0050817|GO:0016337|GO:0045779|GO:0045595|GO:0006810|GO:0007275|GO:0045596|GO:0048513|GO:0016788|GO:0030155|GO:0098609|GO:0043231|GO:0005737|GO:0009611|GO:0042592|GO:0050819|GO:0001775|GO:0009966|GO:0048771|GO:0019725|GO:0048871|GO:0010646|GO:0007162|GO:0050865|GO:0007154|GO:0044092|GO:0055085|GO:0007165|GO:0009968|GO:0051649|GO:0045124|GO:2000021|GO:0050790|GO:0051238|GO:0034103|GO:0043086|GO:0048869|GO:0019538|GO:0031324|GO:0031323|GO:0050878|GO:0034104|GO:0032268|GO:0046850|GO:0030193|GO:0030168|GO:0043412|GO:0030097|GO:0010544|GO:0048878|GO:0001894|GO:0007596|GO:0032386|GO:0034109|GO:0051208|GO:0036211|GO:0032269|GO:0046851|GO:0042060|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0046849|GO:0030195|GO:0022408|GO:0022407|GO:0051279|GO:0007599|GO:0034765|GO:0043269|GO:0061045|GO:0010543|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0010522|GO:0030154|GO:0005634|GO:0042578|GO:0045638|GO:0045637|GO:0034220|GO:0002521|GO:0002761|GO:0016311|GO:0098655|GO:0070527|GO:0006812|GO:0090330|GO:0016310|GO:0060402|GO:0016482|GO:0002762|GO:0045453|GO:0050801|GO:0016791|GO:0033673|GO:0034111|GO:0090331|GO:0030099|GO:0006464|GO:0043549|GO:0006873|GO:0090279|GO:0061041|GO:0006470|GO:1903169|GO:0002573|GO:0045859|GO:0006469|GO:0006468|GO:0042325|GO:0004721|GO:0001932|GO:0042326|GO:0030001|GO:0051924|GO:0001933|GO:0045670|GO:0030003|GO:0045671|GO:0035335|GO:0070588|GO:0055065|GO:0097553|GO:0030316|GO:0006875|GO:0004725|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|cell adhesion|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|hydrolase activity|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|regulation of hemopoiesis|regulation of sequestering of calcium ion|coagulation|single organismal cell-cell adhesion|negative regulation of bone resorption|regulation of cell differentiation|transport|multicellular organism development|negative regulation of cell differentiation|animal organ development|hydrolase activity, acting on ester bonds|regulation of cell adhesion|cell-cell adhesion|intracellular membrane-bounded organelle|cytoplasm|response to wounding|homeostatic process|negative regulation of coagulation|cell activation|regulation of signal transduction|tissue remodeling|cellular homeostasis|multicellular organismal homeostasis|regulation of cell communication|negative regulation of cell adhesion|regulation of cell activation|cell communication|negative regulation of molecular function|transmembrane transport|signal transduction|negative regulation of signal transduction|establishment of localization in cell|regulation of bone resorption|regulation of ion homeostasis|regulation of catalytic activity|sequestering of metal ion|regulation of tissue remodeling|negative regulation of catalytic activity|cellular developmental process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|negative regulation of tissue remodeling|regulation of cellular protein metabolic process|regulation of bone remodeling|regulation of blood coagulation|platelet activation|macromolecule modification|hemopoiesis|negative regulation of platelet activation|chemical homeostasis|tissue homeostasis|blood coagulation|regulation of intracellular transport|homotypic cell-cell adhesion|sequestering of calcium ion|protein modification process|negative regulation of cellular protein metabolic process|negative regulation of bone remodeling|wound healing|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|bone remodeling|negative regulation of blood coagulation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of release of sequestered calcium ion into cytosol|hemostasis|regulation of ion transmembrane transport|regulation of ion transport|negative regulation of wound healing|regulation of platelet activation|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of calcium ion transport into cytosol|cell differentiation|nucleus|phosphoric ester hydrolase activity|negative regulation of myeloid cell differentiation|regulation of myeloid cell differentiation|ion transmembrane transport|leukocyte differentiation|regulation of myeloid leukocyte differentiation|dephosphorylation|cation transmembrane transport|platelet aggregation|cation transport|regulation of platelet aggregation|phosphorylation|calcium ion transport into cytosol|cytosolic transport|negative regulation of myeloid leukocyte differentiation|bone resorption|ion homeostasis|phosphatase activity|negative regulation of kinase activity|negative regulation of homotypic cell-cell adhesion|negative regulation of platelet aggregation|myeloid cell differentiation|cellular protein modification process|regulation of kinase activity|cellular ion homeostasis|regulation of calcium ion import|regulation of wound healing|protein dephosphorylation|regulation of calcium ion transmembrane transport|myeloid leukocyte differentiation|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|negative regulation of phosphorylation|metal ion transport|regulation of calcium ion transport|negative regulation of protein phosphorylation|regulation of osteoclast differentiation|cellular cation homeostasis|negative regulation of osteoclast differentiation|peptidyl-tyrosine dephosphorylation|calcium ion transmembrane transport|metal ion homeostasis|calcium ion transmembrane import into cytosol|osteoclast differentiation|cellular metal ion homeostasis|protein tyrosine phosphatase activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration - - - - 11:122655675-122814473 701 845 1311 2102 2341 2071 4.72567555793392 5.17705723156269 7.96825091453301 12.6962797965047 12.9483819054508 13.0844357918948 5.95699456800987 12.9096991646168 -1.11579883319221 8.25152747515943e-07 1.03766260001436e-05 DOWN ENSG00000153786 ZDHHC7 zinc finger, DHHC-type containing 7 [Source:HGNC Symbol;Acc:HGNC:18459] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0043231|GO:0043169|GO:0016746|GO:0005737|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0005730|GO:0034645|GO:0046872|GO:0043412|GO:0036211|GO:0042157|GO:0031981|GO:0005654|GO:0016747|GO:0044267|GO:0000139|GO:0009059|GO:0005634|GO:0016409|GO:0042158|GO:0046914|GO:0006464|GO:0019706|GO:0018193|GO:0006497|GO:0008270|GO:0018345|GO:0018230 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|intracellular membrane-bounded organelle|cation binding|transferase activity, transferring acyl groups|cytoplasm|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|nucleolus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|protein modification process|lipoprotein metabolic process|nuclear lumen|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|nucleus|palmitoyltransferase activity|lipoprotein biosynthetic process|transition metal ion binding|cellular protein modification process|protein-cysteine S-palmitoyltransferase activity|peptidyl-amino acid modification|protein lipidation|zinc ion binding|protein palmitoylation|peptidyl-L-cysteine S-palmitoylation - - - - 16:84974181-85011535 1716 2130 1911 1005 764 1167 15.1163668990918 17.0525698600704 15.1776695913969 7.93220534368186 5.52194071614523 9.6345200706541 15.782202116853 7.69622204349373 1.03607619305337 8.2821785062943e-07 1.04107855632383e-05 UP ENSG00000141965 FEM1A fem-1 homolog a (C. elegans) [Source:HGNC Symbol;Acc:HGNC:16934] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0050794|GO:0006950|GO:0071704|GO:0044237|GO:0009605|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0005102|GO:0006952|GO:0005737|GO:0009611|GO:0019787|GO:0050790|GO:0019538|GO:0031323|GO:0032268|GO:0043412|GO:0004842|GO:0050727|GO:0036211|GO:0006954|GO:0050728|GO:0001664|GO:0044267|GO:0051246|GO:0051438|GO:0006464|GO:0031867|GO:0032446|GO:0031396|GO:0016567 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|regulation of cellular process|response to stress|organic substance metabolic process|cellular metabolic process|response to external stimulus|intracellular|protein binding|transferase activity|regulation of metabolic process|receptor binding|defense response|cytoplasm|response to wounding|ubiquitin-like protein transferase activity|regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|ubiquitin-protein transferase activity|regulation of inflammatory response|protein modification process|inflammatory response|negative regulation of inflammatory response|G-protein coupled receptor binding|cellular protein metabolic process|regulation of protein metabolic process|regulation of ubiquitin-protein transferase activity|cellular protein modification process|EP4 subtype prostaglandin E2 receptor binding|protein modification by small protein conjugation|regulation of protein ubiquitination|protein ubiquitination - - - - 19:4791681-4801273 1077 1138 769 470 583 457 7.94158159657456 7.6262974527898 5.11247997420773 3.1051782376545 3.52718369885283 3.15817716482215 6.89345300785736 3.26351303377649 1.07880102496674 8.29427919014341e-07 1.04216082046524e-05 UP ENSG00000224897 POT1-AS1 POT1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49459] - - - - - - 7:124929873-125179315 1 3 1 15 21 17 0.00827100203630363 0.0225446857053621 0.00745028960026233 0.11111275479155 0.142450290688523 0.131720278742638 0.0127553257806427 0.128427774740904 -3.33178559206557 8.62734303801742e-07 1.08309797753142e-05 DOWN ENSG00000251246 RP11-540D14.8 - GO:0016020 membrane - - - - 1:155063748-155086807 10 5 10 0 0 0 0.678824980308686 0.308509534600017 0.612073435669036 0 0 0 0.533135983525913 0 Inf 8.63786660556351e-07 1.08396330240644e-05 UP ENSG00000139517 LNX2 ligand of numb-protein X 2 [Source:HGNC Symbol;Acc:HGNC:20421] GO:0009987|GO:0005488|GO:0043167|GO:0016043|GO:0005515|GO:0022607|GO:0043169|GO:0019904|GO:0046872|GO:0030165|GO:0006461|GO:0051259|GO:0046914|GO:0051260|GO:0008270 cellular process|binding|ion binding|cellular component organization|protein binding|cellular component assembly|cation binding|protein domain specific binding|metal ion binding|PDZ domain binding|protein complex assembly|protein oligomerization|transition metal ion binding|protein homooligomerization|zinc ion binding - - - - 13:27545911-27620404 145 176 342 505 683 659 2.21674164352727 2.44533502613275 4.71397445343551 6.91728390230231 8.5671270290742 9.4419292220548 3.12535037436518 8.30878005114377 -1.41061873134045 8.79800466549897e-07 1.10313158876021e-05 DOWN ENSG00000114126 TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) [Source:HGNC Symbol;Acc:HGNC:11751] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0007049|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0071559|GO:0005667|GO:0009890|GO:0019904|GO:0006139|GO:0007154|GO:0007165|GO:0008134|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0007166|GO:0010629|GO:0051252|GO:0010628|GO:0000278|GO:0071560|GO:0031981|GO:0070848|GO:0005654|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0045892|GO:0032774|GO:2001141|GO:0071363|GO:1902679|GO:0007179|GO:0007167|GO:0007219|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006352|GO:0006357|GO:1903506|GO:0007178|GO:0006367 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cell cycle|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|response to transforming growth factor beta|transcription factor complex|negative regulation of biosynthetic process|protein domain specific binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|transcription factor binding|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|mitotic cell cycle|cellular response to transforming growth factor beta stimulus|nuclear lumen|response to growth factor|nucleoplasm|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|negative regulation of RNA biosynthetic process|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|Notch signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway|transcription initiation from RNA polymerase II promoter K09392 transcription factor Dp-2[-] hsa04110 Cell cycle - Homo sapiens (human) 3:141944428-142149544 228 243 484 721 832 939 0.61592443088102 0.596595181587617 1.17883430155297 1.74512216281584 1.84409928531274 2.37732069005048 0.797117971340536 1.98884737939302 -1.31906741041013 8.93922710261174e-07 1.11942821275743e-05 DOWN ENSG00000196865 NHLRC2 NHL repeat containing 2 [Source:HGNC Symbol;Acc:HGNC:24731] GO:0005488|GO:0005515 binding|protein binding - - - - 10:113854661-113917194 201 229 497 741 841 1052 1.22537926670652 1.26879450148796 2.73178121933508 4.04754295315603 4.20667726870444 6.01063071743594 1.74198499584319 4.7549503130988 -1.44869806801478 9.04061350885569e-07 1.13164979326364e-05 DOWN ENSG00000168283 BMI1 BMI1 proto-oncogene, polycomb ring finger [Source:HGNC Symbol;Acc:HGNC:1066] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0048144|GO:0005737|GO:0007389|GO:0031519|GO:0009890|GO:0019904|GO:0006139|GO:0043085|GO:0050790|GO:0000151|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0030097|GO:0010629|GO:0051252|GO:0006325|GO:0071535|GO:0051347|GO:0036211|GO:0048145|GO:0003002|GO:0031981|GO:0051351|GO:1990234|GO:0051247|GO:0048146|GO:0005654|GO:0032270|GO:0007379|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0016070|GO:0035102|GO:0005634|GO:0000152|GO:0031401|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0046914|GO:0016568|GO:0051438|GO:0051443|GO:0006464|GO:0006351|GO:0035282|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0018193|GO:0043687|GO:0000122|GO:0008270|GO:0032446|GO:0031398|GO:0031396|GO:0018205|GO:0016925|GO:0016567 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|fibroblast proliferation|cytoplasm|pattern specification process|PcG protein complex|negative regulation of biosynthetic process|protein domain specific binding|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of catalytic activity|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|hemopoiesis|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|RING-like zinc finger domain binding|positive regulation of transferase activity|protein modification process|regulation of fibroblast proliferation|regionalization|nuclear lumen|positive regulation of ligase activity|transferase complex|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|nucleoplasm|positive regulation of cellular protein metabolic process|segment specification|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|PRC1 complex|nucleus|nuclear ubiquitin ligase complex|positive regulation of protein modification process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transition metal ion binding|chromatin modification|regulation of ubiquitin-protein transferase activity|positive regulation of ubiquitin-protein transferase activity|cellular protein modification process|transcription, DNA-templated|segmentation|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|post-translational protein modification|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|protein modification by small protein conjugation|positive regulation of protein ubiquitination|regulation of protein ubiquitination|peptidyl-lysine modification|protein sumoylation|protein ubiquitination K11459 polycomb group RING finger protein 4[-] hsa05206|hsa05202|hsa04550 MicroRNAs in cancer - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) 10:22321211-22331484 470 633 580 1103 1387 1245 4.81830414311047 5.89766560010273 5.36091821465819 10.1314116102317 11.6665130569326 11.961756370662 5.3589626526238 11.2532270126088 -1.0703131059263 9.10544949786326e-07 1.13928788478294e-05 DOWN ENSG00000070669 ASNS asparagine synthetase (glutamine-hydrolyzing) [Source:HGNC Symbol;Acc:HGNC:753] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0048037|GO:0009605|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0048856|GO:0042802|GO:0051726|GO:0007049|GO:0009314|GO:0009612|GO:0010941|GO:0006082|GO:0009991|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0033554|GO:0010243|GO:0005737|GO:0006520|GO:0031668|GO:0046983|GO:0045787|GO:0060548|GO:0007154|GO:0007165|GO:0009725|GO:0008219|GO:0000166|GO:0044249|GO:0019538|GO:0010033|GO:0048732|GO:0042594|GO:0009636|GO:0005829|GO:0034698|GO:0031427|GO:0030968|GO:0035639|GO:0016884|GO:0006984|GO:0043069|GO:0001883|GO:0001889|GO:0043200|GO:0000278|GO:0032549|GO:0006986|GO:0007346|GO:0008652|GO:0009267|GO:0012501|GO:0014070|GO:0043603|GO:0044267|GO:0071310|GO:0017076|GO:0031669|GO:0035967|GO:0045931|GO:0031667|GO:0034976|GO:0032870|GO:0009416|GO:0042803|GO:0043067|GO:0006528|GO:0034620|GO:0004066|GO:0032354|GO:0042149|GO:0005524|GO:0030554|GO:0036499|GO:0042981|GO:0043066|GO:0019752|GO:0006915|GO:0006541|GO:0006529|GO:0070981 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cofactor binding|response to external stimulus|biosynthetic process|ligase activity|intracellular|protein binding|anatomical structure development|identical protein binding|regulation of cell cycle|cell cycle|response to radiation|response to mechanical stimulus|regulation of cell death|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|cellular response to stress|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|cellular response to extracellular stimulus|protein dimerization activity|positive regulation of cell cycle|negative regulation of cell death|cell communication|signal transduction|response to hormone|cell death|nucleotide binding|cellular biosynthetic process|protein metabolic process|response to organic substance|gland development|response to starvation|response to toxic substance|cytosol|response to gonadotropin|response to methotrexate|endoplasmic reticulum unfolded protein response|purine ribonucleoside triphosphate binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|ER-nucleus signaling pathway|negative regulation of programmed cell death|purine nucleoside binding|liver development|response to amino acid|mitotic cell cycle|ribonucleoside binding|response to unfolded protein|regulation of mitotic cell cycle|cellular amino acid biosynthetic process|cellular response to starvation|programmed cell death|response to organic cyclic compound|cellular amide metabolic process|cellular protein metabolic process|cellular response to organic substance|purine nucleotide binding|cellular response to nutrient levels|cellular response to topologically incorrect protein|positive regulation of mitotic cell cycle|response to nutrient levels|response to endoplasmic reticulum stress|cellular response to hormone stimulus|response to light stimulus|protein homodimerization activity|regulation of programmed cell death|asparagine metabolic process|cellular response to unfolded protein|asparagine synthase (glutamine-hydrolyzing) activity|response to follicle-stimulating hormone|cellular response to glucose starvation|ATP binding|adenyl nucleotide binding|PERK-mediated unfolded protein response|regulation of apoptotic process|negative regulation of apoptotic process|carboxylic acid metabolic process|apoptotic process|glutamine metabolic process|asparagine biosynthetic process|L-asparagine biosynthetic process K01953 asparagine synthase (glutamine-hydrolysing)[6.3.5.4] hsa01100|hsa00250 Metabolic pathways - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human) 7:97852118-97872542 705 806 594 1929 2207 1303 5.13589229064287 5.33631579042696 3.90145846145641 12.5908886770244 13.1915769057138 8.89610564435927 4.79122218084208 11.5595237423658 -1.27061633789408 9.22909168646606e-07 1.15427441645479e-05 DOWN ENSG00000228065 LINC01515 long intergenic non-protein coding RNA 1515 [Source:HGNC Symbol;Acc:HGNC:51210] - - - - - - 10:65570338-65768835 28 46 41 105 137 112 0.168304386768994 0.251292989092216 0.222195785973372 0.56549669527324 0.675665620281205 0.630941553370127 0.213931053944861 0.624034622974857 -1.54448015819425 9.24055056986966e-07 1.15522360432533e-05 DOWN ENSG00000179242 CDH4 cadherin 4, type 1, R-cadherin (retinal) [Source:HGNC Symbol;Acc:HGNC:1763] GO:0040011|GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0050794|GO:0016049|GO:0043167|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0071944|GO:0040008|GO:0009605|GO:0031224|GO:0050793|GO:0048589|GO:0005886|GO:0048856|GO:0006935|GO:0045595|GO:0048468|GO:0051130|GO:0007275|GO:0032535|GO:0030307|GO:0051128|GO:0022607|GO:0098609|GO:0005887|GO:0045597|GO:0043169|GO:0006928|GO:0048639|GO:0031226|GO:0048588|GO:0048638|GO:0030030|GO:0048869|GO:0016021|GO:0001558|GO:0060560|GO:0000902|GO:0031175|GO:0098742|GO:0031344|GO:0045216|GO:0046872|GO:0010720|GO:0031346|GO:0000904|GO:0034329|GO:0050769|GO:0008361|GO:0022604|GO:0030516|GO:0032990|GO:0007399|GO:0097485|GO:0010770|GO:0030154|GO:0048858|GO:1990138|GO:0051960|GO:0045773|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0007157|GO:0010769|GO:0034332|GO:0005509|GO:0061564|GO:0007156|GO:0050772|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0010976|GO:0048675|GO:0045666|GO:0007409|GO:0048699|GO:0050770|GO:0045664 locomotion|developmental process|growth|cell|membrane|cellular process|response to stimulus|binding|regulation of cellular process|cell growth|ion binding|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|cell periphery|regulation of growth|response to external stimulus|intrinsic component of membrane|regulation of developmental process|developmental growth|plasma membrane|anatomical structure development|chemotaxis|regulation of cell differentiation|cell development|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component size|positive regulation of cell growth|regulation of cellular component organization|cellular component assembly|cell-cell adhesion|integral component of plasma membrane|positive regulation of cell differentiation|cation binding|movement of cell or subcellular component|positive regulation of developmental growth|intrinsic component of plasma membrane|developmental cell growth|regulation of developmental growth|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell growth|developmental growth involved in morphogenesis|cell morphogenesis|neuron projection development|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of cell projection organization|cell-cell junction organization|metal ion binding|positive regulation of cell development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|cell junction assembly|positive regulation of neurogenesis|regulation of cell size|regulation of cell morphogenesis|regulation of axon extension|cell part morphogenesis|nervous system development|neuron projection guidance|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|cell projection morphogenesis|neuron projection extension|regulation of nervous system development|positive regulation of axon extension|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|regulation of cell morphogenesis involved in differentiation|adherens junction organization|calcium ion binding|axon development|homophilic cell adhesion via plasma membrane adhesion molecules|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|axon extension|positive regulation of neuron differentiation|axonogenesis|generation of neurons|regulation of axonogenesis|regulation of neuron differentiation - - - - 20:61252426-61940617 37 60 24 9 7 10 0.311168852752997 0.458594474467265 0.181976756576791 0.0678154338789074 0.0483020127266279 0.0788167840360935 0.317246694599018 0.0649780768805429 2.28758018188891 9.29885117927941e-07 1.16202554669823e-05 UP ENSG00000265415 CTD-2510F5.4 - - - - - - - 17:59202677-59203829 15 17 28 69 70 69 3.30540989002157 3.4047182554581 5.56298662789483 13.6234222253629 12.6563311228557 14.2500952182734 4.0910382577915 13.509949522164 -1.7234833503448 9.4790028730319e-07 1.18354726796945e-05 DOWN ENSG00000181143 MUC16 mucin 16, cell surface associated [Source:HGNC Symbol;Acc:HGNC:15582] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 19:8848844-8981342 530 568 1284 1985 2209 6420 0.846688298001283 0.824662897315368 1.84938419604012 2.84122786339949 2.89542081369611 9.61195910074199 1.17357846378559 5.11620259261253 -2.12415909191099 9.4876186717953e-07 1.18412779192214e-05 DOWN ENSG00000178718 RPP25 ribonuclease P/MRP 25kDa subunit [Source:HGNC Symbol;Acc:HGNC:30361] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0006139|GO:0003723|GO:0005815|GO:0031981|GO:0004518|GO:0005654|GO:0010467|GO:0016070|GO:0005856|GO:0005634|GO:0090501|GO:0006396|GO:0034660|GO:0015630|GO:0004519|GO:0004540|GO:0044822|GO:0090305|GO:0006399|GO:0090502|GO:0004521|GO:0008033|GO:0004526|GO:0016891 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|RNA binding|microtubule organizing center|nuclear lumen|nuclease activity|nucleoplasm|gene expression|RNA metabolic process|cytoskeleton|nucleus|RNA phosphodiester bond hydrolysis|RNA processing|ncRNA metabolic process|microtubule cytoskeleton|endonuclease activity|ribonuclease activity|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|tRNA metabolic process|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|tRNA processing|ribonuclease P activity|endoribonuclease activity, producing 5'-phosphomonoesters K14525 ribonucleases P/MRP protein subunit RPP25[3.1.26.5] hsa03013|hsa03008 RNA transport - Homo sapiens (human)|Ribosome biogenesis in eukaryotes - Homo sapiens (human) 15:74954416-74957464 1287 1332 786 509 626 335 29.8584136059506 28.084882934717 16.4408704172982 10.5804513041588 11.9160012146909 7.28387844262107 24.7947223193219 9.92677698715692 1.32063578186254 9.64843909512451e-07 1.20369620035874e-05 UP ENSG00000214765 SEPT7P2 septin 7 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:32339] - - - - - - 7:45723780-45768985 99 126 113 283 319 266 1.05338762126029 1.21844164590294 1.0840482859122 2.69798016918168 2.78492010428033 2.65255630110341 1.11862585102514 2.71181885818847 -1.27753323778976 9.66967977040454e-07 1.20584218824418e-05 DOWN ENSG00000269476 CTD-2583A14.9 - - - - - - - 19:57876765-57916591 1 0 0 7 11 15 0.069379111198641 0 0 0.434935205041 0.625887153610991 0.97492864133978 0.023126370399547 0.678583666663924 -4.87491594209635 9.76192774755887e-07 1.21632967852931e-05 DOWN ENSG00000177710 SLC35G5 solute carrier family 35 member G5 [Source:HGNC Symbol;Acc:HGNC:15546] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 8:11330888-11332208 11 8 10 0 1 0 0.589025225514205 0.389325069366053 0.482801302019027 0 0.0439539951433402 0 0.487050532299762 0.0146513317144467 5.05496775439509 9.77359716620464e-07 1.21727563537703e-05 UP ENSG00000134697 GNL2 guanine nucleotide binding protein-like 2 (nucleolar) [Source:HGNC Symbol;Acc:HGNC:29925] GO:0005623|GO:0016020|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0003676|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0000166|GO:0016021|GO:0022613|GO:0005730|GO:0003723|GO:0035639|GO:0001883|GO:0042254|GO:0016818|GO:0032549|GO:0031981|GO:0017076|GO:0005634|GO:0032561|GO:0044822|GO:0005525|GO:0019001|GO:0016462|GO:0017111|GO:0003924 cell|membrane|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|nucleic acid binding|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|nucleotide binding|integral component of membrane|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribosome biogenesis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|purine nucleotide binding|nucleus|guanyl ribonucleotide binding|poly(A) RNA binding|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|GTPase activity K14537 nuclear GTP-binding protein[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 1:37566816-37595935 2490 2576 2278 1439 1460 983 22.943179379783 21.5714906282332 18.92439726356 11.8799011705305 11.0376052915627 8.48861113056448 21.1463557571921 10.4687058642192 1.01432595079217 9.81860667396576e-07 1.22186195766809e-05 UP ENSG00000162650 ATXN7L2 ataxin 7-like 2 [Source:HGNC Symbol;Acc:HGNC:28713] - - - - - - 1:109483479-109492804 225 284 169 100 91 81 1.57597917261605 1.80786154970351 1.06725323495918 0.627576285379477 0.522971282064331 0.531721016249053 1.48369798575958 0.560756194564287 1.40375189627727 9.94672887961788e-07 1.23729018321713e-05 UP ENSG00000248101 AC002116.8 - - - - - - - 19:36008638-36014235 0 0 0 11 11 5 0 0 0 0.616953380149698 0.564960085560363 0.293362162512383 0 0.491758542740815 -Inf 9.98549988932424e-07 1.24159564221527e-05 DOWN ENSG00000155016 CYP2U1 cytochrome P450 family 2 subfamily U member 1 [Source:HGNC Symbol;Acc:HGNC:20582] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0044255|GO:0006082|GO:0009410|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0004497|GO:0006629|GO:0005783|GO:0006805|GO:0016021|GO:0055114|GO:0046872|GO:0020037|GO:0006631|GO:0008395|GO:0071466|GO:0016712|GO:0006690|GO:0033559|GO:0070330|GO:0001676|GO:0019369|GO:0046914|GO:0019752|GO:0097267|GO:0005506|GO:0032787 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|lipid metabolic process|endoplasmic reticulum|xenobiotic metabolic process|integral component of membrane|oxidation-reduction process|metal ion binding|heme binding|fatty acid metabolic process|steroid hydroxylase activity|cellular response to xenobiotic stimulus|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|icosanoid metabolic process|unsaturated fatty acid metabolic process|aromatase activity|long-chain fatty acid metabolic process|arachidonic acid metabolic process|transition metal ion binding|carboxylic acid metabolic process|omega-hydroxylase P450 pathway|iron ion binding|monocarboxylic acid metabolic process K07422 cytochrome P450, family 2, subfamily U, polypeptide 1[-] hsa01100|hsa00590 Metabolic pathways - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human) 4:107931369-107953457 9 11 11 42 38 53 0.0734720365848741 0.0816146275277131 0.0809607845109036 0.30720504227063 0.254526567411709 0.405489625565086 0.0786824828744969 0.322407078415808 -2.03476902985856 1.0004798099965e-06 1.2434772792521e-05 DOWN ENSG00000134779 TPGS2 tubulin polyglutamylase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:24561] GO:0005623|GO:0043229|GO:0005622|GO:0005874|GO:0005737|GO:0005856|GO:0015630 cell|intracellular organelle|intracellular|microtubule|cytoplasm|cytoskeleton|microtubule cytoskeleton - - - - 18:36777647-36829216 315 335 307 736 912 616 1.29186568723214 1.24862457219075 1.1351670541708 2.70447034805944 3.06880924552404 2.36764650251935 1.22521910453123 2.71364203203428 -1.14719065351709 1.00852969555931e-06 1.25296069626415e-05 DOWN ENSG00000176108 CHMP6 charged multivesicular body protein 6 [Source:HGNC Symbol;Acc:HGNC:25675] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0000920|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0016032|GO:0047485|GO:0007049|GO:0051640|GO:0006810|GO:0022402|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0051656|GO:0045184|GO:0008104|GO:0000815|GO:0061024|GO:0070062|GO:0051649|GO:0010008|GO:0007059|GO:0051301|GO:0005768|GO:0006996|GO:0016192|GO:0051276|GO:0005829|GO:0000819|GO:0006900|GO:0016050|GO:1903047|GO:0007080|GO:0019068|GO:0015031|GO:0000278|GO:0046907|GO:0005770|GO:0007067|GO:0019058|GO:0006997|GO:0046755|GO:0031902|GO:0051303|GO:0039702|GO:0016197|GO:0000070|GO:0051310|GO:0007034 macromolecular complex|cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|cell separation after cytokinesis|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|viral process|protein N-terminus binding|cell cycle|organelle localization|transport|cell cycle process|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|establishment of organelle localization|establishment of protein localization|protein localization|ESCRT III complex|membrane organization|extracellular exosome|establishment of localization in cell|endosome membrane|chromosome segregation|cell division|endosome|organelle organization|vesicle-mediated transport|chromosome organization|cytosol|sister chromatid segregation|membrane budding|vesicle organization|mitotic cell cycle process|mitotic metaphase plate congression|virion assembly|protein transport|mitotic cell cycle|intracellular transport|late endosome|mitotic nuclear division|viral life cycle|nucleus organization|viral budding|late endosome membrane|establishment of chromosome localization|viral budding via host ESCRT complex|endosomal transport|mitotic sister chromatid segregation|metaphase plate congression|vacuolar transport K12195 charged multivesicular body protein 6[-] hsa04144 Endocytosis - Homo sapiens (human) 17:80991598-81009517 36 44 38 128 144 96 1.12281339860306 1.24719633663098 1.06856226963024 3.57693679930629 3.68496527712209 2.80608784855174 1.14619066828809 3.35599664166004 -1.5498942163643 1.01607103733891e-06 1.26180469004642e-05 DOWN ENSG00000085721 RRN3 RRN3 homolog, RNA polymerase I transcription factor [Source:HGNC Symbol;Acc:HGNC:30346] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:0048468|GO:0051130|GO:1901360|GO:0010941|GO:0007275|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0045597|GO:0043231|GO:0019899|GO:0042592|GO:0009966|GO:0060548|GO:0007028|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0030030|GO:0048869|GO:0044249|GO:0022613|GO:0043254|GO:0031323|GO:0006996|GO:0005730|GO:0031175|GO:0003677|GO:0031344|GO:0010468|GO:0034645|GO:0010720|GO:0043069|GO:2001234|GO:0051252|GO:0031346|GO:0009790|GO:0042254|GO:0010628|GO:0048872|GO:0070063|GO:0031981|GO:0050769|GO:0005654|GO:0006461|GO:2000142|GO:0012501|GO:0035556|GO:0010467|GO:0007399|GO:1902532|GO:0006997|GO:0031328|GO:0009059|GO:0030154|GO:1902531|GO:0016070|GO:0010557|GO:0005634|GO:0043067|GO:0051960|GO:0097190|GO:0048666|GO:0030182|GO:0000975|GO:0045893|GO:0097193|GO:0010975|GO:2001242|GO:0009792|GO:1901797|GO:0072331|GO:0032774|GO:0043565|GO:2001141|GO:2001243|GO:0003690|GO:0007000|GO:1901796|GO:0042981|GO:0043066|GO:0022008|GO:0050767|GO:0010976|GO:0006351|GO:0006915|GO:0006355|GO:0045666|GO:0072332|GO:0006352|GO:0006360|GO:0048699|GO:1903506|GO:0044212|GO:0043009|GO:1902254|GO:1902253|GO:0045664|GO:0006361|GO:0001047|GO:0000976|GO:0001701|GO:0001013|GO:0001046|GO:0001164 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|homeostatic process|regulation of signal transduction|negative regulation of cell death|cytoplasm organization|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|cell death|cell projection organization|cellular developmental process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of protein complex assembly|regulation of cellular metabolic process|organelle organization|nucleolus|neuron projection development|DNA binding|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|positive regulation of cell development|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|positive regulation of cell projection organization|embryo development|ribosome biogenesis|positive regulation of gene expression|homeostasis of number of cells|RNA polymerase binding|nuclear lumen|positive regulation of neurogenesis|nucleoplasm|protein complex assembly|regulation of DNA-templated transcription, initiation|programmed cell death|intracellular signal transduction|gene expression|nervous system development|negative regulation of intracellular signal transduction|nucleus organization|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|regulation of nervous system development|apoptotic signaling pathway|neuron development|neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|regulation of neuron projection development|regulation of intrinsic apoptotic signaling pathway|embryo development ending in birth or egg hatching|negative regulation of signal transduction by p53 class mediator|signal transduction by p53 class mediator|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway|double-stranded DNA binding|nucleolus organization|regulation of signal transduction by p53 class mediator|regulation of apoptotic process|negative regulation of apoptotic process|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|intrinsic apoptotic signaling pathway by p53 class mediator|DNA-templated transcription, initiation|transcription from RNA polymerase I promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of neuron differentiation|transcription initiation from RNA polymerase I promoter|core promoter binding|transcription regulatory region sequence-specific DNA binding|in utero embryonic development|RNA polymerase I regulatory region DNA binding|core promoter sequence-specific DNA binding|RNA polymerase I CORE element sequence-specific DNA binding - - - - 16:15060022-15094317 2422 2838 1964 1249 1439 858 29.2862633802262 31.1876250765234 21.411422812344 13.5316280342114 14.2764015824862 9.72312679074747 27.2951037563645 12.5103854691484 1.12551593877398 1.02046809784299e-06 1.26673823671537e-05 UP ENSG00000163629 PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) [Source:HGNC Symbol;Acc:HGNC:9646] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0044297|GO:0016043|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0016788|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0043005|GO:0009966|GO:0030027|GO:0010646|GO:0007154|GO:0007165|GO:0070062|GO:0043548|GO:0019538|GO:0045216|GO:0036312|GO:0043412|GO:0036211|GO:0034329|GO:0006796|GO:0035556|GO:0044267|GO:1902531|GO:0005856|GO:0005634|GO:0042578|GO:0016311|GO:0048017|GO:0016791|GO:0014066|GO:0006464|GO:0007043|GO:0006470|GO:0070830|GO:0048015|GO:0043297|GO:0004721|GO:0035335|GO:0014065|GO:0004725 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|cell body|cellular component organization|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|intracellular|protein binding|plasma membrane|hydrolase activity, acting on ester bonds|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|neuron projection|regulation of signal transduction|lamellipodium|regulation of cell communication|cell communication|signal transduction|extracellular exosome|phosphatidylinositol 3-kinase binding|protein metabolic process|cell-cell junction organization|phosphatidylinositol 3-kinase regulatory subunit binding|macromolecule modification|protein modification process|cell junction assembly|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of intracellular signal transduction|cytoskeleton|nucleus|phosphoric ester hydrolase activity|dephosphorylation|inositol lipid-mediated signaling|phosphatase activity|regulation of phosphatidylinositol 3-kinase signaling|cellular protein modification process|cell-cell junction assembly|protein dephosphorylation|bicellular tight junction assembly|phosphatidylinositol-mediated signaling|apical junction assembly|phosphoprotein phosphatase activity|peptidyl-tyrosine dephosphorylation|phosphatidylinositol 3-kinase signaling|protein tyrosine phosphatase activity K02374 tyrosine-protein phosphatase non-receptor type 13[-] hsa04210 Apoptosis - Homo sapiens (human) 4:86594315-86815171 125 151 282 451 485 821 0.725002137150579 0.795950560724612 1.47465918535561 2.34370045042602 2.30801230046604 4.4627285240977 0.998537294410267 3.03814709166325 -1.60530350243867 1.02779696814824e-06 1.27530551484197e-05 DOWN ENSG00000198205 ZXDA zinc finger, X-linked, duplicated A [Source:HGNC Symbol;Acc:HGNC:13198] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0019904|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010628|GO:0070742|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|protein domain specific binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|positive regulation of gene expression|C2H2 zinc finger domain binding|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:57906708-57910820 266 396 300 147 156 151 4.57476030550634 6.18960186545764 4.65182308790126 2.26518278659142 2.20130546384159 2.43384800718275 5.13872841962175 2.30011208587192 1.15970724182679 1.03122333262808e-06 1.2779635272843e-05 UP ENSG00000197892 KIF13B kinesin family member 13B [Source:HGNC Symbol;Acc:HGNC:14405] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0045321|GO:0043229|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0007155|GO:0016787|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0016337|GO:0045595|GO:0048468|GO:0006810|GO:0007275|GO:0070489|GO:0043168|GO:0005874|GO:0001882|GO:0051128|GO:0016817|GO:0098609|GO:0019899|GO:0005737|GO:0071889|GO:0006928|GO:0032403|GO:0001775|GO:0043005|GO:0045184|GO:0005875|GO:0008104|GO:0046649|GO:0007154|GO:0007165|GO:0051649|GO:0008092|GO:0000166|GO:0030030|GO:0048869|GO:0007017|GO:0033270|GO:0015631|GO:0000902|GO:0005829|GO:0031175|GO:0031344|GO:0005871|GO:0035639|GO:0030424|GO:0001883|GO:0015031|GO:0000904|GO:0008017|GO:0016818|GO:0046907|GO:0032549|GO:0044304|GO:0007018|GO:0007159|GO:0022604|GO:0034613|GO:0019900|GO:0042110|GO:0032990|GO:0007399|GO:0017076|GO:0005902|GO:0030154|GO:0048858|GO:0005856|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0010769|GO:0005524|GO:0030554|GO:0006605|GO:0070486|GO:0061564|GO:0006886|GO:0015630|GO:0019901|GO:0022008|GO:0048667|GO:0030705|GO:0050767|GO:0048812|GO:0016462|GO:0007409|GO:0048699|GO:0017111|GO:0050770|GO:0071593|GO:0045664|GO:0016887|GO:0003774|GO:0003777 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|leukocyte activation|intracellular organelle|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|cell adhesion|hydrolase activity|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|single organismal cell-cell adhesion|regulation of cell differentiation|cell development|transport|multicellular organism development|T cell aggregation|anion binding|microtubule|nucleoside binding|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|cell-cell adhesion|enzyme binding|cytoplasm|14-3-3 protein binding|movement of cell or subcellular component|protein complex binding|cell activation|neuron projection|establishment of protein localization|microtubule associated complex|protein localization|lymphocyte activation|cell communication|signal transduction|establishment of localization in cell|cytoskeletal protein binding|nucleotide binding|cell projection organization|cellular developmental process|microtubule-based process|paranode region of axon|tubulin binding|cell morphogenesis|cytosol|neuron projection development|regulation of cell projection organization|kinesin complex|purine ribonucleoside triphosphate binding|axon|purine nucleoside binding|protein transport|cell morphogenesis involved in differentiation|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|main axon|microtubule-based movement|leukocyte cell-cell adhesion|regulation of cell morphogenesis|cellular protein localization|kinase binding|T cell activation|cell part morphogenesis|nervous system development|purine nucleotide binding|microvillus|cell differentiation|cell projection morphogenesis|cytoskeleton|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|ATP binding|adenyl nucleotide binding|protein targeting|leukocyte aggregation|axon development|intracellular protein transport|microtubule cytoskeleton|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|cytoskeleton-dependent intracellular transport|regulation of neurogenesis|neuron projection morphogenesis|pyrophosphatase activity|axonogenesis|generation of neurons|nucleoside-triphosphatase activity|regulation of axonogenesis|lymphocyte aggregation|regulation of neuron differentiation|ATPase activity|motor activity|microtubule motor activity - - - - 8:29067279-29263124 471 483 1024 1523 1622 2418 2.6242174921932 2.44571497549216 5.14390804472205 7.60285133510562 7.41477066154027 12.6259475108055 3.4046135041358 9.21452316915046 -1.4364184805263 1.04119425817929e-06 1.28978478770475e-05 DOWN ENSG00000272669 RP3-508I15.21 - - - - - - - 22:38742625-38743115 7 6 15 34 48 44 1.00848894320082 0.785588212778853 1.94834502194263 4.38876755686423 5.6737563660312 5.94078488874054 1.24747405930743 5.33443627054532 -2.09632600317262 1.04329217710812e-06 1.29184755932749e-05 DOWN ENSG00000231607 DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:13748] - - - - - - 13:49982552-50125720 33 40 37 94 138 110 0.264151518469254 0.290991522367634 0.267031181362627 0.674166322327297 0.906329990461089 0.825206371993235 0.274058074066505 0.801900894927207 -1.54894230959098 1.04899789264961e-06 1.29837409150752e-05 DOWN ENSG00000257218 GATC glutamyl-tRNA(Gln) amidotransferase, subunit C [Source:HGNC Symbol;Acc:HGNC:25068] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0006139|GO:0030956|GO:0006450|GO:0000166|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0035639|GO:0016884|GO:0007005|GO:0001883|GO:0032549|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0051246|GO:0009059|GO:0016070|GO:0032543|GO:0043043|GO:0043039|GO:0005524|GO:0034660|GO:0030554|GO:0010608|GO:0006412|GO:0050567|GO:0006417|GO:0019752|GO:0006414|GO:0070681|GO:0006399 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|nucleobase-containing compound metabolic process|glutamyl-tRNA(Gln) amidotransferase complex|regulation of translational fidelity|nucleotide binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|purine ribonucleoside triphosphate binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|mitochondrion organization|purine nucleoside binding|ribonucleoside binding|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|mitochondrial translation|peptide biosynthetic process|tRNA aminoacylation|ATP binding|ncRNA metabolic process|adenyl nucleotide binding|posttranscriptional regulation of gene expression|translation|glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity|regulation of translation|carboxylic acid metabolic process|translational elongation|glutaminyl-tRNAGln biosynthesis via transamidation|tRNA metabolic process K02435 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C[6.3.5.7] hsa01100|hsa00970 Metabolic pathways - Homo sapiens (human)|Aminoacyl-tRNA biosynthesis - Homo sapiens (human) 12:120446438-120463749 197 242 309 602 614 518 2.69747219895529 3.01152286162114 3.81473431171728 7.3855963811602 6.89806805639278 6.64737081444686 3.17457645743124 6.97701175066661 -1.13604513879446 1.06084413466238e-06 1.3124923661919e-05 DOWN ENSG00000124164 VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C [Source:HGNC Symbol;Acc:HGNC:12649] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0042802|GO:0016032|GO:0044255|GO:0006725|GO:0006810|GO:1901360|GO:0051702|GO:0034641|GO:0044281|GO:0048524|GO:0031325|GO:0046483|GO:0033554|GO:0051668|GO:0043231|GO:0019899|GO:0005737|GO:0032403|GO:0042592|GO:0046983|GO:0019725|GO:0019904|GO:0006139|GO:0043085|GO:0007154|GO:0061024|GO:0006629|GO:0007165|GO:0005783|GO:0051649|GO:0008092|GO:0048525|GO:0050790|GO:0016021|GO:0044249|GO:0019538|GO:0050792|GO:0010033|GO:0031323|GO:0010256|GO:0005794|GO:0006996|GO:0051701|GO:0016192|GO:0019048|GO:0015631|GO:0032268|GO:0006665|GO:0019054|GO:0006900|GO:0016050|GO:0030968|GO:0043412|GO:0090114|GO:0051345|GO:0046725|GO:0046982|GO:0048878|GO:0044793|GO:0044794|GO:0032075|GO:0008017|GO:0006643|GO:0019076|GO:0051347|GO:0036211|GO:0046907|GO:0055082|GO:0006986|GO:0051247|GO:0032270|GO:0033149|GO:0006796|GO:0044267|GO:1903902|GO:0051174|GO:0019079|GO:0008610|GO:0019058|GO:0007029|GO:0071310|GO:0000139|GO:0051246|GO:0035967|GO:0034976|GO:0042803|GO:0034620|GO:0044829|GO:1902186|GO:0031401|GO:0048487|GO:0016310|GO:0044790|GO:0045069|GO:0048193|GO:0044828|GO:0045070|GO:0045071|GO:0050801|GO:0044791|GO:0030148|GO:0006464|GO:0006987|GO:0043549|GO:1902187|GO:0006873|GO:0033674|GO:1902188|GO:0045859|GO:0045860|GO:0006468|GO:0042325|GO:0001932|GO:0001934|GO:0006888|GO:0030003|GO:0042327|GO:0055065|GO:0006875|GO:0006874|GO:0055074 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|identical protein binding|viral process|cellular lipid metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|interaction with symbiont|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|localization within membrane|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein complex binding|homeostatic process|protein dimerization activity|cellular homeostasis|protein domain specific binding|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|membrane organization|lipid metabolic process|signal transduction|endoplasmic reticulum|establishment of localization in cell|cytoskeletal protein binding|negative regulation of viral process|regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|protein metabolic process|regulation of viral process|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|interaction with host|vesicle-mediated transport|modulation by virus of host morphology or physiology|tubulin binding|regulation of cellular protein metabolic process|sphingolipid metabolic process|modulation by virus of host process|membrane budding|vesicle organization|endoplasmic reticulum unfolded protein response|macromolecule modification|COPII-coated vesicle budding|positive regulation of hydrolase activity|negative regulation by virus of viral protein levels in host cell|protein heterodimerization activity|chemical homeostasis|negative regulation by host of viral process|positive regulation by host of viral process|positive regulation of nuclease activity|microtubule binding|membrane lipid metabolic process|viral release from host cell|positive regulation of transferase activity|protein modification process|intracellular transport|cellular chemical homeostasis|response to unfolded protein|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|FFAT motif binding|phosphate-containing compound metabolic process|cellular protein metabolic process|positive regulation of viral life cycle|regulation of phosphorus metabolic process|viral genome replication|lipid biosynthetic process|viral life cycle|endoplasmic reticulum organization|cellular response to organic substance|Golgi membrane|regulation of protein metabolic process|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|protein homodimerization activity|cellular response to unfolded protein|positive regulation by host of viral genome replication|regulation of viral release from host cell|positive regulation of protein modification process|beta-tubulin binding|phosphorylation|negative regulation by host of viral release from host cell|regulation of viral genome replication|Golgi vesicle transport|negative regulation by host of viral genome replication|positive regulation of viral genome replication|negative regulation of viral genome replication|ion homeostasis|positive regulation by host of viral release from host cell|sphingolipid biosynthetic process|cellular protein modification process|activation of signaling protein activity involved in unfolded protein response|regulation of kinase activity|negative regulation of viral release from host cell|cellular ion homeostasis|positive regulation of kinase activity|positive regulation of viral release from host cell|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|ER to Golgi vesicle-mediated transport|cellular cation homeostasis|positive regulation of phosphorylation|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis - - - - 20:58389122-58451101 591 662 828 1536 1706 1296 2.6012998817969 2.64813980621366 3.28584564357229 6.05747741741546 6.16097871607805 5.34609638929339 2.84509511052762 5.85485084092897 -1.04115553475108 1.06574336410252e-06 1.31800755558893e-05 DOWN ENSG00000033100 CHPF2 chondroitin polymerizing factor 2 [Source:HGNC Symbol;Acc:HGNC:29270] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006082|GO:0044281|GO:0043231|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0034645|GO:0008194|GO:0030204|GO:0009100|GO:0016758|GO:0005795|GO:1901137|GO:0000139|GO:0009059|GO:0009101|GO:0030206|GO:0031985|GO:0015020|GO:0050650|GO:0032580|GO:0006024|GO:0006029|GO:0030203|GO:0008376|GO:0030166|GO:0050510 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|cellular macromolecule biosynthetic process|UDP-glycosyltransferase activity|chondroitin sulfate metabolic process|glycoprotein metabolic process|transferase activity, transferring hexosyl groups|Golgi stack|carbohydrate derivative biosynthetic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|chondroitin sulfate biosynthetic process|Golgi cisterna|glucuronosyltransferase activity|chondroitin sulfate proteoglycan biosynthetic process|Golgi cisterna membrane|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|glycosaminoglycan metabolic process|acetylgalactosaminyltransferase activity|proteoglycan biosynthetic process|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity K03419 chondroitin polymerizing factor 2[2.4.1.226] hsa01100 Metabolic pathways - Homo sapiens (human) 7:151232489-151238827 713 847 732 1531 1833 1709 7.46085542096562 8.0549461738085 6.90596635964897 14.3539620196958 15.7372751917841 16.7598495908434 7.47392265147436 15.6170289341078 -1.06318247539253 1.07924127032815e-06 1.33414777989137e-05 DOWN ENSG00000163611 SPICE1 spindle and centriole associated protein 1 [Source:HGNC Symbol;Acc:HGNC:25083] GO:0005623|GO:0009987|GO:0050794|GO:0043229|GO:0051641|GO:0016043|GO:0005622|GO:0051726|GO:0007049|GO:0051640|GO:1902115|GO:0022402|GO:0051128|GO:0022607|GO:0005737|GO:0032886|GO:0051656|GO:0051649|GO:0007059|GO:0051301|GO:0007017|GO:0006996|GO:0031023|GO:0005813|GO:1903047|GO:0007010|GO:0070507|GO:0005815|GO:0007098|GO:0098534|GO:0005814|GO:0000278|GO:0046599|GO:0010564|GO:0007099|GO:0007051|GO:0006461|GO:0070925|GO:0033043|GO:0007067|GO:0051298|GO:0000226|GO:0005856|GO:0005819|GO:0051303|GO:0051225|GO:0007052|GO:0051493|GO:0015630|GO:0051297|GO:0051310|GO:0010824|GO:0046605|GO:0090307 cell|cellular process|regulation of cellular process|intracellular organelle|cellular localization|cellular component organization|intracellular|regulation of cell cycle|cell cycle|organelle localization|regulation of organelle assembly|cell cycle process|regulation of cellular component organization|cellular component assembly|cytoplasm|regulation of microtubule-based process|establishment of organelle localization|establishment of localization in cell|chromosome segregation|cell division|microtubule-based process|organelle organization|microtubule organizing center organization|centrosome|mitotic cell cycle process|cytoskeleton organization|regulation of microtubule cytoskeleton organization|microtubule organizing center|centrosome cycle|centriole assembly|centriole|mitotic cell cycle|regulation of centriole replication|regulation of cell cycle process|centriole replication|spindle organization|protein complex assembly|organelle assembly|regulation of organelle organization|mitotic nuclear division|centrosome duplication|microtubule cytoskeleton organization|cytoskeleton|spindle|establishment of chromosome localization|spindle assembly|mitotic spindle organization|regulation of cytoskeleton organization|microtubule cytoskeleton|centrosome organization|metaphase plate congression|regulation of centrosome duplication|regulation of centrosome cycle|mitotic spindle assembly - - - - 3:113442718-113515187 278 359 573 943 892 1055 2.18425615382366 2.56349793080571 4.05907541297208 6.63846765351169 5.75030792912397 7.76855225672474 2.93560983253382 6.7191092797868 -1.19460975998634 1.08203886544205e-06 1.33705249540178e-05 DOWN ENSG00000175662 TOM1L2 target of myb1 like 2 membrane trafficking protein [Source:HGNC Symbol;Acc:HGNC:11984] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0051726|GO:0007049|GO:0006810|GO:0022402|GO:0051302|GO:0031982|GO:0051128|GO:0030276|GO:0045786|GO:0019899|GO:0051782|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0051649|GO:0051301|GO:0006996|GO:1903047|GO:0015031|GO:0000278|GO:0046907|GO:0007346|GO:0010564|GO:0045930|GO:0034613|GO:0019900|GO:0033043|GO:0007067|GO:0010948|GO:0007088|GO:0006886|GO:0045839|GO:0019901 signaling|cell|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|regulation of cell cycle|cell cycle|transport|cell cycle process|regulation of cell division|vesicle|regulation of cellular component organization|clathrin binding|negative regulation of cell cycle|enzyme binding|negative regulation of cell division|establishment of protein localization|protein localization|cell communication|signal transduction|extracellular exosome|establishment of localization in cell|cell division|organelle organization|mitotic cell cycle process|protein transport|mitotic cell cycle|intracellular transport|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|cellular protein localization|kinase binding|regulation of organelle organization|mitotic nuclear division|negative regulation of cell cycle process|regulation of mitotic nuclear division|intracellular protein transport|negative regulation of mitotic nuclear division|protein kinase binding - - - - 17:17843511-17972422 163 211 372 588 631 770 0.874157238712398 1.02840418220937 1.79869860557951 2.82537217350856 2.77650398777987 3.87008650228427 1.23375334216709 3.15732088785757 -1.35564690060008 1.10005355688338e-06 1.35818853958629e-05 DOWN ENSG00000148229 POLE3 polymerase (DNA directed), epsilon 3, accessory subunit [Source:HGNC Symbol;Acc:HGNC:13546] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0016772|GO:0046483|GO:0043231|GO:0046983|GO:0006139|GO:0044249|GO:0019538|GO:1990391|GO:0006996|GO:0051276|GO:0003677|GO:0034645|GO:0043412|GO:0046982|GO:0006325|GO:0016573|GO:0036211|GO:0005657|GO:0031981|GO:1990234|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0044267|GO:0008622|GO:0000123|GO:0009059|GO:0016779|GO:0005634|GO:0000109|GO:0034061|GO:0006260|GO:0043596|GO:0043966|GO:0005671|GO:0016568|GO:0006464|GO:0071897|GO:0018193|GO:0003887|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|protein dimerization activity|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|DNA repair complex|organelle organization|chromosome organization|DNA binding|cellular macromolecule biosynthetic process|macromolecule modification|protein heterodimerization activity|chromatin organization|histone acetylation|protein modification process|replication fork|nuclear lumen|transferase complex|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|cellular protein metabolic process|epsilon DNA polymerase complex|histone acetyltransferase complex|macromolecule biosynthetic process|nucleotidyltransferase activity|nucleus|nucleotide-excision repair complex|DNA polymerase activity|DNA replication|nuclear replication fork|histone H3 acetylation|Ada2/Gcn5/Ada3 transcription activator complex|chromatin modification|cellular protein modification process|DNA biosynthetic process|peptidyl-amino acid modification|DNA-directed DNA polymerase activity|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation K02326 DNA polymerase epsilon subunit 3[2.7.7.7] hsa01100|hsa05166|hsa00230|hsa00240|hsa03420|hsa03030|hsa03410 Metabolic pathways - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Nucleotide excision repair - Homo sapiens (human)|DNA replication - Homo sapiens (human)|Base excision repair - Homo sapiens (human) 9:113407235-113410672 3859 4030 2922 1931 2125 1380 81.9986507625962 77.8246297610527 55.979151488307 36.7630792307362 37.0474975851986 27.481472770071 71.9341440039853 33.7640165286686 1.09119018211163 1.11562620956513e-06 1.3768460049755e-05 UP ENSG00000072864 NDE1 nudE neurodevelopment protein 1 [Source:HGNC Symbol;Acc:HGNC:17619] GO:0040011|GO:0032502|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0009986|GO:0051641|GO:0048870|GO:0016043|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0042802|GO:0007049|GO:0051640|GO:0006810|GO:0022402|GO:0007275|GO:0048513|GO:0005874|GO:0000776|GO:0030900|GO:0007420|GO:0022607|GO:0005737|GO:0060322|GO:0021987|GO:0006928|GO:0032403|GO:0051656|GO:0019904|GO:0005875|GO:0007163|GO:0007154|GO:0010970|GO:0016477|GO:0007165|GO:0051649|GO:0008092|GO:0061351|GO:0021543|GO:0007059|GO:0051301|GO:0048869|GO:0021537|GO:0007017|GO:0032154|GO:0006996|GO:0072089|GO:0031023|GO:0051650|GO:0015631|GO:0005829|GO:0051653|GO:0005813|GO:0005871|GO:1903047|GO:0007010|GO:0007417|GO:0051299|GO:0005815|GO:0007405|GO:0044770|GO:0007098|GO:0008017|GO:0000278|GO:0046907|GO:0001764|GO:0030010|GO:0007018|GO:0005694|GO:0006461|GO:0051293|GO:0051642|GO:0035556|GO:0007067|GO:0051298|GO:0007399|GO:0051648|GO:0030154|GO:0000226|GO:0072384|GO:0005856|GO:0000922|GO:0005819|GO:0000777|GO:0051303|GO:0031616|GO:0034622|GO:0000086|GO:0047496|GO:0051294|GO:0000793|GO:0044772|GO:0007100|GO:0043623|GO:0015630|GO:0007020|GO:0031109|GO:0051297|GO:0040001|GO:0000132|GO:0022008|GO:0007264|GO:0030705|GO:0000775|GO:0051258|GO:0000779|GO:0048699|GO:0046785 locomotion|developmental process|macromolecular complex|synapse|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|cell surface|cellular localization|cell motility|cellular component organization|intracellular|protein binding|protein complex|anatomical structure development|identical protein binding|cell cycle|organelle localization|transport|cell cycle process|multicellular organism development|animal organ development|microtubule|kinetochore|forebrain development|brain development|cellular component assembly|cytoplasm|head development|cerebral cortex development|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|protein domain specific binding|microtubule associated complex|establishment or maintenance of cell polarity|cell communication|establishment of localization by movement along microtubule|cell migration|signal transduction|establishment of localization in cell|cytoskeletal protein binding|neural precursor cell proliferation|pallium development|chromosome segregation|cell division|cellular developmental process|telencephalon development|microtubule-based process|cleavage furrow|organelle organization|stem cell proliferation|microtubule organizing center organization|establishment of vesicle localization|tubulin binding|cytosol|spindle localization|centrosome|kinesin complex|mitotic cell cycle process|cytoskeleton organization|central nervous system development|centrosome separation|microtubule organizing center|neuroblast proliferation|cell cycle phase transition|centrosome cycle|microtubule binding|mitotic cell cycle|intracellular transport|neuron migration|establishment of cell polarity|microtubule-based movement|chromosome|protein complex assembly|establishment of spindle localization|centrosome localization|intracellular signal transduction|mitotic nuclear division|centrosome duplication|nervous system development|vesicle localization|cell differentiation|microtubule cytoskeleton organization|organelle transport along microtubule|cytoskeleton|spindle pole|spindle|condensed chromosome kinetochore|establishment of chromosome localization|spindle pole centrosome|cellular macromolecular complex assembly|G2/M transition of mitotic cell cycle|vesicle transport along microtubule|establishment of spindle orientation|condensed chromosome|mitotic cell cycle phase transition|mitotic centrosome separation|cellular protein complex assembly|microtubule cytoskeleton|microtubule nucleation|microtubule polymerization or depolymerization|centrosome organization|establishment of mitotic spindle localization|establishment of mitotic spindle orientation|neurogenesis|small GTPase mediated signal transduction|cytoskeleton-dependent intracellular transport|chromosome, centromeric region|protein polymerization|condensed chromosome, centromeric region|generation of neurons|microtubule polymerization - - - - 16:15643267-15726353 212 262 292 589 550 612 2.05175047413447 2.30445658020471 2.54791680730116 5.10741166784659 4.36735537169198 5.5509581854142 2.30137462054678 5.00857507498426 -1.12190437293517 1.1287531193187e-06 1.39132104145914e-05 DOWN ENSG00000133460 SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 [Source:HGNC Symbol;Acc:HGNC:14239] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0022857|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0006810|GO:0043231|GO:0022891|GO:0055085|GO:0016021|GO:0008643|GO:0005634 transporter activity|cell|membrane|cellular process|cell junction|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|transport|intracellular membrane-bounded organelle|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|carbohydrate transport|nucleus - - - - 22:23856703-23886309 117 137 179 338 365 354 0.413706138473094 0.440259475605618 0.57065588302024 1.07083343567996 1.05893291759591 1.1731125002364 0.474873832366317 1.10095961783742 -1.21314538850998 1.1351461588136e-06 1.39820380792922e-05 DOWN ENSG00000143164 DCAF6 DDB1 and CUL4 associated factor 6 [Source:HGNC Symbol;Acc:HGNC:30002] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0000988|GO:0030055|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0034641|GO:0005924|GO:0005912|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0000151|GO:0044249|GO:0019538|GO:0031323|GO:0003713|GO:0010468|GO:0034645|GO:0043412|GO:0031461|GO:0051252|GO:0010628|GO:0036211|GO:1990234|GO:0044267|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0005925|GO:0045893|GO:0032774|GO:2001141|GO:0030374|GO:0080008|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0032446|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|cell junction|binding|transcription factor activity, protein binding|cell-substrate junction|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|cell-substrate adherens junction|adherens junction|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|cullin-RING ubiquitin ligase complex|regulation of RNA metabolic process|positive regulation of gene expression|protein modification process|transferase complex|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|focal adhesion|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|ligand-dependent nuclear receptor transcription coactivator activity|Cul4-RING E3 ubiquitin ligase complex|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|protein modification by small protein conjugation|protein ubiquitination - - - - 1:167935783-168075843 640 717 898 1553 1751 1506 4.65565617412488 4.74023303325285 5.88967731687233 10.1220857682532 10.4509286180334 10.2672649650776 5.09518884141669 10.2800931171214 -1.01264580987085 1.16675659996759e-06 1.43520195860867e-05 DOWN ENSG00000186230 ZNF749 zinc finger protein 749 [Source:HGNC Symbol;Acc:HGNC:32783] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57435329-57445485 362 358 359 170 217 147 5.96754660552689 5.36351762859634 5.33576166530258 2.5109205858517 2.93504007900367 2.27107978449811 5.55560863314194 2.57234681645116 1.11085980470374 1.17198211311764e-06 1.44103599691162e-05 UP ENSG00000077380 DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 [Source:HGNC Symbol;Acc:HGNC:2964] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0044877|GO:0019882|GO:0043229|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0016032|GO:0007049|GO:0019884|GO:0006810|GO:0022402|GO:0005874|GO:0031982|GO:0016817|GO:0005737|GO:0006928|GO:0032403|GO:0005875|GO:0002504|GO:0048002|GO:0007017|GO:0006996|GO:0005829|GO:0005813|GO:1903047|GO:0005815|GO:0044770|GO:0016818|GO:0000278|GO:0007018|GO:0030286|GO:0005856|GO:0002495|GO:0000086|GO:0044772|GO:0019886|GO:0015630|GO:0005868|GO:0016462|GO:0017111|GO:0003774|GO:0003777 macromolecular complex|immune system process|cell|cellular process|metabolic process|binding|catalytic activity|macromolecular complex binding|antigen processing and presentation|intracellular organelle|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|viral process|cell cycle|antigen processing and presentation of exogenous antigen|transport|cell cycle process|microtubule|vesicle|hydrolase activity, acting on acid anhydrides|cytoplasm|movement of cell or subcellular component|protein complex binding|microtubule associated complex|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|antigen processing and presentation of peptide antigen|microtubule-based process|organelle organization|cytosol|centrosome|mitotic cell cycle process|microtubule organizing center|cell cycle phase transition|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|microtubule-based movement|dynein complex|cytoskeleton|antigen processing and presentation of peptide antigen via MHC class II|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule cytoskeleton|cytoplasmic dynein complex|pyrophosphatase activity|nucleoside-triphosphatase activity|motor activity|microtubule motor activity K10415 dynein intermediate chain, cytosolic[-] hsa04145|hsa05132|hsa04962 Phagosome - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Vasopressin-regulated water reabsorption - Homo sapiens (human) 2:171687409-171748420 846 1121 1146 2057 2459 2129 5.23655733409182 6.30610403435514 6.39550040552406 11.4079472974041 12.4882628631478 12.3503720347841 5.97938725799034 12.082194065112 -1.01481290865107 1.18450594785474e-06 1.45583534653172e-05 DOWN ENSG00000279207 RP11-159D12.8 - - - - - - - 17:58095672-58101479 661 863 847 371 445 165 8.05045430261299 9.55234727414094 9.30071882775671 4.04846674233559 4.446793556481 1.88334845137416 8.96784013483688 3.45953625006358 1.37418190224852 1.18653671467983e-06 1.45773115555768e-05 UP ENSG00000125485 DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 [Source:HGNC Symbol;Acc:HGNC:16715] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0012505|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0016817|GO:0043231|GO:0005737|GO:0006139|GO:0000166|GO:0022613|GO:0005794|GO:0005730|GO:0003723|GO:0035639|GO:0001883|GO:0042254|GO:0016818|GO:0032549|GO:0031981|GO:0017076|GO:0016070|GO:0005634|GO:0010501|GO:0005524|GO:0030554|GO:0044822|GO:0016462|GO:0017111|GO:0016887|GO:0004386|GO:0042623|GO:0003724|GO:0008026|GO:0004004|GO:0008186 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|endomembrane system|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nucleotide binding|ribonucleoprotein complex biogenesis|Golgi apparatus|nucleolus|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribosome biogenesis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|purine nucleotide binding|RNA metabolic process|nucleus|RNA secondary structure unwinding|ATP binding|adenyl nucleotide binding|poly(A) RNA binding|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|helicase activity|ATPase activity, coupled|RNA helicase activity|ATP-dependent helicase activity|ATP-dependent RNA helicase activity|RNA-dependent ATPase activity - - - - 9:132592997-132670401 166 183 135 469 556 338 1.57024626062939 1.57322903251238 1.15135108321988 3.97494330573934 4.31521869659748 2.9964432478851 1.43160879212055 3.76220175007397 -1.39393990712596 1.20359270489386e-06 1.4780771950597e-05 DOWN ENSG00000130826 DKC1 dyskeratosis congenita 1, dyskerin [Source:HGNC Symbol;Acc:HGNC:2890] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0016853|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0006725|GO:0051130|GO:1901360|GO:0003676|GO:0016866|GO:0034641|GO:0032204|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0032206|GO:0043231|GO:0000723|GO:0005737|GO:0030529|GO:0042592|GO:0006139|GO:0043085|GO:0050790|GO:0016021|GO:0044249|GO:0022613|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0007004|GO:0034645|GO:0003723|GO:0010833|GO:0043412|GO:0042254|GO:0009982|GO:0005732|GO:0051347|GO:0072588|GO:1904358|GO:0031981|GO:0005654|GO:0006259|GO:0005697|GO:0051054|GO:0033043|GO:0010467|GO:0031328|GO:1904356|GO:0009059|GO:0016779|GO:0016070|GO:0010557|GO:0005634|GO:0010638|GO:2001252|GO:0006364|GO:0034061|GO:0032200|GO:0006260|GO:0072589|GO:0006396|GO:0030515|GO:0051972|GO:0034660|GO:0031429|GO:0051973|GO:0033044|GO:0009451|GO:0016604|GO:0032212|GO:2000278|GO:0016071|GO:0006275|GO:0090661|GO:0044822|GO:0070034|GO:2000573|GO:0045740|GO:0071897|GO:0032210|GO:0006278|GO:0034513|GO:0016556|GO:0016074|GO:0015030|GO:0016073|GO:0016072|GO:0003964|GO:0000154|GO:0001522|GO:0031123|GO:0040031|GO:0033979|GO:0031120|GO:0031118|GO:1990481|GO:0003720|GO:0000495 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|isomerase activity|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|positive regulation of cellular component organization|organic cyclic compound metabolic process|nucleic acid binding|intramolecular transferase activity|cellular nitrogen compound metabolic process|regulation of telomere maintenance|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of telomere maintenance|intracellular membrane-bounded organelle|telomere maintenance|cytoplasm|intracellular ribonucleoprotein complex|homeostatic process|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|telomere maintenance via telomerase|cellular macromolecule biosynthetic process|RNA binding|telomere maintenance via telomere lengthening|macromolecule modification|ribosome biogenesis|pseudouridine synthase activity|small nucleolar ribonucleoprotein complex|positive regulation of transferase activity|box H/ACA RNP complex|positive regulation of telomere maintenance via telomere lengthening|nuclear lumen|nucleoplasm|DNA metabolic process|telomerase holoenzyme complex|positive regulation of DNA metabolic process|regulation of organelle organization|gene expression|positive regulation of cellular biosynthetic process|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of organelle organization|positive regulation of chromosome organization|rRNA processing|DNA polymerase activity|telomere organization|DNA replication|box H/ACA scaRNP complex|RNA processing|snoRNA binding|regulation of telomerase activity|ncRNA metabolic process|box H/ACA snoRNP complex|positive regulation of telomerase activity|regulation of chromosome organization|RNA modification|nuclear body|positive regulation of telomere maintenance via telomerase|regulation of DNA biosynthetic process|mRNA metabolic process|regulation of DNA replication|box H/ACA telomerase RNP complex|poly(A) RNA binding|telomerase RNA binding|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|DNA biosynthetic process|regulation of telomere maintenance via telomerase|RNA-dependent DNA replication|box H/ACA snoRNA binding|mRNA modification|snoRNA metabolic process|Cajal body|snRNA metabolic process|rRNA metabolic process|RNA-directed DNA polymerase activity|rRNA modification|pseudouridine synthesis|RNA 3'-end processing|snRNA modification|box H/ACA snoRNA metabolic process|snRNA pseudouridine synthesis|rRNA pseudouridine synthesis|mRNA pseudouridine synthesis|telomerase activity|box H/ACA snoRNA 3'-end processing K11131 H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-][-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) X:154762742-154777689 6004 6543 4179 2674 3151 1606 52.8765012081119 52.3695711618341 33.1824664890007 21.0999369210413 22.7687055783235 13.2555160930268 46.1428462863156 19.0413861974639 1.27696848881279 1.20726214589911e-06 1.48195678745242e-05 UP ENSG00000164414 SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 [Source:HGNC Symbol;Acc:HGNC:11021] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0022857|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0006486|GO:0044255|GO:0006810|GO:0005338|GO:0005887|GO:0043231|GO:0005737|GO:0005975|GO:0022891|GO:0031226|GO:0055085|GO:0006629|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006490|GO:0034645|GO:0043412|GO:0006487|GO:0009100|GO:0036211|GO:0006811|GO:0015075|GO:0051119|GO:0070085|GO:1901137|GO:0044267|GO:0015165|GO:0000139|GO:0009059|GO:1901264|GO:0008643|GO:0015932|GO:0009101|GO:0006820|GO:0043413|GO:0015711|GO:0015293|GO:0015992|GO:0008509|GO:0006488|GO:0006812|GO:0018279|GO:0006464|GO:0005456|GO:0008324|GO:0015782|GO:0015781|GO:0005351|GO:0018193|GO:0008514|GO:0043687|GO:0015672|GO:0015295 transporter activity|cell|membrane|cellular process|metabolic process|transmembrane transporter activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|organelle membrane|protein glycosylation|cellular lipid metabolic process|transport|nucleotide-sugar transmembrane transporter activity|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|lipid metabolic process|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|macromolecule modification|protein N-linked glycosylation|glycoprotein metabolic process|protein modification process|ion transport|ion transmembrane transporter activity|sugar transmembrane transporter activity|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|pyrimidine nucleotide-sugar transmembrane transporter activity|Golgi membrane|macromolecule biosynthetic process|carbohydrate derivative transport|carbohydrate transport|nucleobase-containing compound transmembrane transporter activity|glycoprotein biosynthetic process|anion transport|macromolecule glycosylation|organic anion transport|symporter activity|proton transport|anion transmembrane transporter activity|dolichol-linked oligosaccharide biosynthetic process|cation transport|protein N-linked glycosylation via asparagine|cellular protein modification process|CMP-N-acetylneuraminate transmembrane transporter activity|cation transmembrane transporter activity|CMP-N-acetylneuraminate transport|pyrimidine nucleotide-sugar transport|sugar:proton symporter activity|peptidyl-amino acid modification|organic anion transmembrane transporter activity|post-translational protein modification|monovalent inorganic cation transport|solute:proton symporter activity - - - - 6:87470623-87512336 44 63 73 205 200 133 0.750882820655502 0.977112293278467 1.12320812381893 3.13453751894399 2.80039736570862 2.12717307677755 0.950401079250966 2.68736932047672 -1.49958622249875 1.23840352041547e-06 1.51770520108717e-05 DOWN ENSG00000122696 SLC25A51 solute carrier family 25 member 51 [Source:HGNC Symbol;Acc:HGNC:23323] GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003735|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0006810|GO:0034641|GO:0043231|GO:0005737|GO:0031966|GO:0016021|GO:0044249|GO:0019538|GO:0005740|GO:0034645|GO:0006518|GO:0005743|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0043043|GO:0006412 structural molecule activity|cell|membrane|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|transport|cellular nitrogen compound metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|integral component of membrane|cellular biosynthetic process|protein metabolic process|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|mitochondrial inner membrane|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|peptide biosynthetic process|translation - - - - 9:37879400-37904353 319 330 305 154 151 167 3.76963475194998 3.54407111361392 3.24954982398005 1.63052634654065 1.46404434974216 1.84950381107366 3.52108522984798 1.64802483578549 1.09528216472437 1.24030709252859e-06 1.51941435947265e-05 UP ENSG00000087008 ACOX3 acyl-CoA oxidase 3, pristanoyl [Source:HGNC Symbol;Acc:HGNC:121] GO:0009055|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0005622|GO:0005515|GO:0044255|GO:0006082|GO:0005102|GO:0043168|GO:0044281|GO:0043231|GO:0005737|GO:0042592|GO:0006629|GO:0016627|GO:0050662|GO:0000166|GO:0000062|GO:0055114|GO:0016042|GO:0050660|GO:0048878|GO:0044242|GO:0006631|GO:0052890|GO:0034440|GO:0005739|GO:0003995|GO:0030258|GO:0005777|GO:0046395|GO:0005782|GO:0003997|GO:0019752|GO:0055088|GO:0009062|GO:0019395|GO:0006635|GO:0016402|GO:0032787|GO:0033539|GO:0033540 electron carrier activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|intracellular|protein binding|cellular lipid metabolic process|organic acid metabolic process|receptor binding|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|lipid metabolic process|oxidoreductase activity, acting on the CH-CH group of donors|coenzyme binding|nucleotide binding|fatty-acyl-CoA binding|oxidation-reduction process|lipid catabolic process|flavin adenine dinucleotide binding|chemical homeostasis|cellular lipid catabolic process|fatty acid metabolic process|oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor|lipid oxidation|mitochondrion|acyl-CoA dehydrogenase activity|lipid modification|peroxisome|carboxylic acid catabolic process|peroxisomal matrix|acyl-CoA oxidase activity|carboxylic acid metabolic process|lipid homeostasis|fatty acid catabolic process|fatty acid oxidation|fatty acid beta-oxidation|pristanoyl-CoA oxidase activity|monocarboxylic acid metabolic process|fatty acid beta-oxidation using acyl-CoA dehydrogenase|fatty acid beta-oxidation using acyl-CoA oxidase K00232 acyl-CoA oxidase[1.3.3.6] hsa01100|hsa04024|hsa04146|hsa03320|hsa01212|hsa00071|hsa00592|hsa01040 Metabolic pathways - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Fatty acid metabolism - Homo sapiens (human)|Fatty acid degradation - Homo sapiens (human)|alpha-Linolenic acid metabolism - Homo sapiens (human)|Biosynthesis of unsaturated fatty acids - Homo sapiens (human) 4:8366282-8440723 56 82 102 191 223 262 0.796877551386831 1.06046243622686 1.30862222060019 2.4351893139262 2.60360492895051 3.4940759018758 1.05532073607129 2.84429004825084 -1.43038705864045 1.24478948641202e-06 1.52427995600265e-05 DOWN ENSG00000196387 ZNF140 zinc finger protein 140 [Source:HGNC Symbol;Acc:HGNC:12925] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 12:133079838-133107544 291 292 201 119 114 101 1.62619905211527 1.48300617847119 1.01272618768744 0.595836391726274 0.522701848516231 0.5289703337142 1.37397713942463 0.549169524652235 1.32303452783595 1.24899300044658e-06 1.52880020645068e-05 UP ENSG00000166398 KIAA0355 KIAA0355 [Source:HGNC Symbol;Acc:HGNC:29016] - - - - - - 19:34254537-34355586 107 127 263 417 483 544 0.714245132648164 0.770455580702057 1.58282474387434 2.49400301417264 2.64531940008154 3.40322341771297 1.02250848574152 2.84751527732238 -1.47759076615392 1.25085385205624e-06 1.53045044669208e-05 DOWN ENSG00000165732 DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 [Source:HGNC Symbol;Acc:HGNC:2744] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0016817|GO:0043231|GO:0009615|GO:0006139|GO:0001503|GO:0000166|GO:0048869|GO:0044249|GO:0022613|GO:0010033|GO:0005730|GO:0034645|GO:0003723|GO:0035639|GO:0001883|GO:0042254|GO:0016818|GO:0043331|GO:0032549|GO:0001649|GO:0031981|GO:0005654|GO:0014070|GO:0010467|GO:0017076|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0006364|GO:0017069|GO:0010501|GO:0006396|GO:0030515|GO:0032774|GO:0005524|GO:0019843|GO:0034660|GO:0030554|GO:0003725|GO:0044822|GO:0043330|GO:0016462|GO:0006351|GO:0006366|GO:0017111|GO:0016072|GO:0097322|GO:0016887|GO:0004386|GO:0042623|GO:0003724|GO:0008026|GO:0004004|GO:0008186 developmental process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|hydrolase activity|biosynthetic process|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|response to virus|nucleobase-containing compound metabolic process|ossification|nucleotide binding|cellular developmental process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|response to organic substance|nucleolus|cellular macromolecule biosynthetic process|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribosome biogenesis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|response to dsRNA|ribonucleoside binding|osteoblast differentiation|nuclear lumen|nucleoplasm|response to organic cyclic compound|gene expression|purine nucleotide binding|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|rRNA processing|snRNA binding|RNA secondary structure unwinding|RNA processing|snoRNA binding|RNA biosynthetic process|ATP binding|rRNA binding|ncRNA metabolic process|adenyl nucleotide binding|double-stranded RNA binding|poly(A) RNA binding|response to exogenous dsRNA|pyrophosphatase activity|transcription, DNA-templated|transcription from RNA polymerase II promoter|nucleoside-triphosphatase activity|rRNA metabolic process|7SK snRNA binding|ATPase activity|helicase activity|ATPase activity, coupled|RNA helicase activity|ATP-dependent helicase activity|ATP-dependent RNA helicase activity|RNA-dependent ATPase activity - - - - 10:68956128-68985073 12397 14644 11534 6986 8024 4847 116.225946120934 124.774614795521 97.4946271306726 58.6830612018477 61.7227618647495 42.5881170877441 112.831729349043 54.3313133847804 1.05431699656398 1.25978453102419e-06 1.54074589877904e-05 UP ENSG00000228463 AP006222.2 - - - - - - - 1:257864-297502 115 81 79 26 25 40 1.14605863260889 0.733629458025148 0.70982896382217 0.232155261984454 0.204415519128 0.373595716942904 0.863172351485403 0.270055499351786 1.6763927268795 1.27363640306741e-06 1.55577500724937e-05 UP ENSG00000166166 TRMT61A tRNA methyltransferase 61A [Source:HGNC Symbol;Acc:HGNC:23790] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0032259|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0043234|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0008168|GO:0043412|GO:0001510|GO:0031981|GO:1990234|GO:0005654|GO:0043527|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0034660|GO:0009451|GO:0031515|GO:0030488|GO:0008173|GO:0008757|GO:0006400|GO:0006399|GO:0008175|GO:0008033|GO:0016429 macromolecular complex|cell|cellular process|metabolic process|catalytic activity|methylation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein complex|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|methyltransferase activity|macromolecule modification|RNA methylation|nuclear lumen|transferase complex|nucleoplasm|tRNA methyltransferase complex|gene expression|RNA metabolic process|nucleus|RNA processing|ncRNA metabolic process|RNA modification|tRNA (m1A) methyltransferase complex|tRNA methylation|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|tRNA modification|tRNA metabolic process|tRNA methyltransferase activity|tRNA processing|tRNA (adenine-N1-)-methyltransferase activity - - - - 14:103529184-103537073 1444 1640 949 606 731 346 31.2845438546619 32.2913620546112 18.537152452854 11.7634040782545 12.9941534882841 7.02534734684745 27.3710194540424 10.5943016377954 1.36936067964138 1.29164495829204e-06 1.57712754948264e-05 UP ENSG00000051341 POLQ polymerase (DNA directed), theta [Source:HGNC Symbol;Acc:HGNC:9186] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0006281|GO:0016445|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0046483|GO:0033554|GO:0016817|GO:0022607|GO:0043231|GO:0002377|GO:0003682|GO:0006139|GO:0002566|GO:0000166|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0034645|GO:0051053|GO:0045738|GO:0000725|GO:0051575|GO:0035639|GO:0016446|GO:0001883|GO:0006284|GO:0006302|GO:0016818|GO:0032549|GO:0031981|GO:2001020|GO:0005654|GO:0006259|GO:0005694|GO:0006461|GO:0006282|GO:0017076|GO:0009059|GO:0016779|GO:0005634|GO:0006974|GO:0006303|GO:0000724|GO:0034061|GO:0006260|GO:0045910|GO:0051259|GO:0005524|GO:0030554|GO:2000779|GO:0003684|GO:0000018|GO:0006310|GO:0016462|GO:0071897|GO:2000780|GO:0010569|GO:0006261|GO:0017111|GO:0097681|GO:0003887|GO:0051260|GO:2000042|GO:0016887|GO:0042623|GO:0008094|GO:0043142 developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|immune system development|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|DNA repair|somatic diversification of immunoglobulins|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|immunoglobulin production|chromatin binding|nucleobase-containing compound metabolic process|somatic diversification of immune receptors via somatic mutation|nucleotide binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|negative regulation of DNA repair|recombinational repair|5'-deoxyribose-5-phosphate lyase activity|purine ribonucleoside triphosphate binding|somatic hypermutation of immunoglobulin genes|purine nucleoside binding|base-excision repair|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|regulation of response to DNA damage stimulus|nucleoplasm|DNA metabolic process|chromosome|protein complex assembly|regulation of DNA repair|purine nucleotide binding|macromolecule biosynthetic process|nucleotidyltransferase activity|nucleus|cellular response to DNA damage stimulus|double-strand break repair via nonhomologous end joining|double-strand break repair via homologous recombination|DNA polymerase activity|DNA replication|negative regulation of DNA recombination|protein oligomerization|ATP binding|adenyl nucleotide binding|regulation of double-strand break repair|damaged DNA binding|regulation of DNA recombination|DNA recombination|pyrophosphatase activity|DNA biosynthetic process|negative regulation of double-strand break repair|regulation of double-strand break repair via homologous recombination|DNA-dependent DNA replication|nucleoside-triphosphatase activity|double-strand break repair via alternative nonhomologous end joining|DNA-directed DNA polymerase activity|protein homooligomerization|negative regulation of double-strand break repair via homologous recombination|ATPase activity|ATPase activity, coupled|DNA-dependent ATPase activity|single-stranded DNA-dependent ATPase activity - - - - 3:121431427-121546641 339 418 513 918 1211 771 2.13514122919462 2.39267679800256 2.91312495057362 5.18045009602893 6.25805620697246 4.55103968573655 2.4803143259236 5.32984866291265 -1.10357160688064 1.29409091208786e-06 1.57946811485981e-05 DOWN ENSG00000196912 ANKRD36B ankyrin repeat domain 36B [Source:HGNC Symbol;Acc:HGNC:29333] GO:0005488|GO:0005515 binding|protein binding - - - - 2:97492663-97589965 37 49 68 128 150 191 0.288242425165799 0.346928218781088 0.477618286241084 0.893446328284875 0.958778221362578 1.39451533616777 0.37092964339599 1.08224662860507 -1.54481183361211 1.29631063738865e-06 1.58153076291789e-05 DOWN ENSG00000163694 RBM47 RNA binding motif protein 47 [Source:HGNC Symbol;Acc:HGNC:30358] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0000166|GO:0048869|GO:0003723|GO:0043412|GO:0030097|GO:0030154|GO:0016070|GO:0005634|GO:0009451|GO:0044822|GO:0002244|GO:0016553|GO:0016554 developmental process|immune system process|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|immune system development|protein binding|anatomical structure development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleotide binding|cellular developmental process|RNA binding|macromolecule modification|hemopoiesis|cell differentiation|RNA metabolic process|nucleus|RNA modification|poly(A) RNA binding|hematopoietic progenitor cell differentiation|base conversion or substitution editing|cytidine to uridine editing - - - - 4:40423267-40630875 1033 1275 1564 2428 2917 2995 3.80936205631961 4.27308942888058 5.19999322995851 8.02228738161917 8.82584288429768 10.3508899142899 4.42748157171957 9.06634006006892 -1.03403397267649 1.31076568477192e-06 1.59851302096327e-05 DOWN ENSG00000101109 STK4 serine/threonine kinase 4 [Source:HGNC Symbol;Acc:HGNC:11408] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0023051|GO:0045926|GO:0009653|GO:0016043|GO:0043227|GO:0040008|GO:0023057|GO:0009893|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0007507|GO:0051726|GO:0042127|GO:0007049|GO:0001890|GO:0045595|GO:0035239|GO:0009888|GO:0035295|GO:0001568|GO:0010941|GO:0007275|GO:0048513|GO:0060706|GO:0060800|GO:0043168|GO:0046620|GO:0008047|GO:0003157|GO:0001882|GO:0016772|GO:0031325|GO:0033554|GO:0046621|GO:0010942|GO:0035265|GO:0051098|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0005737|GO:0007389|GO:0001763|GO:0021915|GO:0009966|GO:0048729|GO:0046983|GO:0048598|GO:0048568|GO:0010646|GO:0001892|GO:0043085|GO:0001525|GO:0007154|GO:0035148|GO:0007165|GO:0009968|GO:0031647|GO:0048638|GO:0008134|GO:0008219|GO:0008285|GO:0048640|GO:0050790|GO:0000166|GO:0019207|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:2001235|GO:0032268|GO:0030111|GO:0000902|GO:0005829|GO:0030178|GO:0046872|GO:0007166|GO:0002009|GO:0035639|GO:0001569|GO:0001944|GO:0043412|GO:0061458|GO:0030097|GO:0072358|GO:0007417|GO:0050821|GO:0019887|GO:0001883|GO:0048754|GO:0061138|GO:0009790|GO:0072175|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0016331|GO:0031098|GO:0045600|GO:0007346|GO:0051099|GO:0035162|GO:0051247|GO:0016301|GO:0043588|GO:0001841|GO:0032270|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0019209|GO:0007399|GO:0060562|GO:0017076|GO:0045598|GO:0051246|GO:0030154|GO:0043068|GO:0072359|GO:0016773|GO:0005634|GO:0042803|GO:0043067|GO:0097190|GO:0045995|GO:0043393|GO:0003158|GO:0016055|GO:0045444|GO:0009792|GO:0031401|GO:0090090|GO:0043065|GO:0030855|GO:0060828|GO:0000287|GO:0005524|GO:0030216|GO:0001838|GO:2001236|GO:0030554|GO:0016310|GO:2001238|GO:0008544|GO:0035329|GO:0032092|GO:0030295|GO:0060215|GO:0042981|GO:0004672|GO:0006464|GO:0097191|GO:0043549|GO:0006915|GO:0033674|GO:0045859|GO:0045860|GO:1902043|GO:0006468|GO:0043539|GO:0060070|GO:0042325|GO:0001932|GO:0018193|GO:0004674|GO:0043009|GO:0001934|GO:0042327|GO:0008625|GO:1902041|GO:0009913|GO:0097284|GO:0046777|GO:0033138|GO:0071902|GO:0018105|GO:0033135|GO:0071900|GO:0001701 developmental process|growth|macromolecular complex|reproduction|immune system process|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|negative regulation of growth|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|immune system development|protein binding|protein complex|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|heart development|regulation of cell cycle|regulation of cell proliferation|cell cycle|placenta development|regulation of cell differentiation|tube morphogenesis|tissue development|tube development|blood vessel development|regulation of cell death|multicellular organism development|animal organ development|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|anion binding|regulation of organ growth|enzyme activator activity|endocardium development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|cellular response to stress|negative regulation of organ growth|positive regulation of cell death|organ growth|regulation of binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|cytoplasm|pattern specification process|morphogenesis of a branching structure|neural tube development|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|embryonic organ development|regulation of cell communication|embryonic placenta development|positive regulation of catalytic activity|angiogenesis|cell communication|tube formation|signal transduction|negative regulation of signal transduction|regulation of protein stability|regulation of developmental growth|transcription factor binding|cell death|negative regulation of cell proliferation|negative regulation of developmental growth|regulation of catalytic activity|nucleotide binding|kinase regulator activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|negative regulation of Wnt signaling pathway|metal ion binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|patterning of blood vessels|vasculature development|macromolecule modification|reproductive system development|hemopoiesis|cardiovascular system development|central nervous system development|protein stabilization|protein kinase regulator activity|purine nucleoside binding|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|embryo development|epithelial tube formation|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|morphogenesis of embryonic epithelium|stress-activated protein kinase signaling cascade|positive regulation of fat cell differentiation|regulation of mitotic cell cycle|positive regulation of binding|embryonic hemopoiesis|positive regulation of protein metabolic process|kinase activity|skin development|neural tube formation|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|kinase activator activity|nervous system development|epithelial tube morphogenesis|purine nucleotide binding|regulation of fat cell differentiation|regulation of protein metabolic process|cell differentiation|positive regulation of programmed cell death|circulatory system development|phosphotransferase activity, alcohol group as acceptor|nucleus|protein homodimerization activity|regulation of programmed cell death|apoptotic signaling pathway|regulation of embryonic development|regulation of protein binding|endothelium development|Wnt signaling pathway|fat cell differentiation|embryo development ending in birth or egg hatching|positive regulation of protein modification process|negative regulation of canonical Wnt signaling pathway|positive regulation of apoptotic process|epithelial cell differentiation|regulation of canonical Wnt signaling pathway|magnesium ion binding|ATP binding|keratinocyte differentiation|embryonic epithelial tube formation|regulation of extrinsic apoptotic signaling pathway|adenyl nucleotide binding|phosphorylation|positive regulation of extrinsic apoptotic signaling pathway|epidermis development|hippo signaling|positive regulation of protein binding|protein kinase activator activity|primitive hemopoiesis|regulation of apoptotic process|protein kinase activity|cellular protein modification process|extrinsic apoptotic signaling pathway|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of extrinsic apoptotic signaling pathway via death domain receptors|protein phosphorylation|protein serine/threonine kinase activator activity|canonical Wnt signaling pathway|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|chordate embryonic development|positive regulation of protein phosphorylation|positive regulation of phosphorylation|extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway via death domain receptors|epidermal cell differentiation|hepatocyte apoptotic process|protein autophosphorylation|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein serine/threonine kinase activity|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|regulation of protein serine/threonine kinase activity|in utero embryonic development K04411 serine/threonine kinase 4[-] hsa05200|hsa04010|hsa04014|hsa04068|hsa05223 Pathways in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human) 20:44966474-45079959 497 578 896 1525 1471 1438 2.28301864916462 2.41302171900889 3.71086863596812 6.27654797426551 5.54413655700752 6.19071950780745 2.80230300138054 6.00380134636016 -1.09926328506482 1.31495842530198e-06 1.60231709505981e-05 DOWN ENSG00000177728 TMEM94 transmembrane protein 94 [Source:HGNC Symbol;Acc:HGNC:28983] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0043231|GO:0016021|GO:0031981|GO:0005654|GO:0005634 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|intracellular membrane-bounded organelle|integral component of membrane|nuclear lumen|nucleoplasm|nucleus - - - - 17:75441159-75500090 278 270 505 765 836 973 1.01595671382902 0.896754058759494 1.66393272907205 2.50489342993498 2.50671288359696 3.33251393256953 1.19221450055352 2.78137341536716 -1.22215362218642 1.31471130634814e-06 1.60231709505981e-05 DOWN ENSG00000197782 ZNF780A zinc finger protein 780A [Source:HGNC Symbol;Acc:HGNC:27603] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:40069152-40090938 40 15 8 160 93 174 0.152441950316491 0.051955172449971 0.0274890585622385 0.546339950758759 0.290800889574239 0.621475165534259 0.0772953937762335 0.486205335289086 -2.65311137655762 1.32488106604205e-06 1.61309132730911e-05 DOWN ENSG00000152767 FARP1 FERM, ARH/RhoGEF and pleckstrin domain protein 1 [Source:HGNC Symbol;Acc:HGNC:3591] GO:0032502|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0005085|GO:0048856|GO:0019222|GO:0009898|GO:0048468|GO:0007275|GO:0016358|GO:0022607|GO:0019899|GO:0005737|GO:0005088|GO:0031234|GO:0098562|GO:0043005|GO:0009966|GO:0019897|GO:0043197|GO:0036477|GO:0010646|GO:0043085|GO:0007154|GO:0044092|GO:0007165|GO:0050808|GO:0008092|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007416|GO:0043412|GO:0044309|GO:0051345|GO:0048813|GO:0000904|GO:0036211|GO:0032269|GO:0030425|GO:0051346|GO:0030175|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0051246|GO:0051020|GO:0030154|GO:0048858|GO:0005089|GO:1902531|GO:0005856|GO:0048666|GO:0030182|GO:0010923|GO:0016311|GO:0030676|GO:0043087|GO:0043547|GO:0031267|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0010921|GO:0006470|GO:0035304|GO:0007265|GO:0046578|GO:0017016|GO:0048699|GO:0035305|GO:0035303|GO:0035308|GO:0017048|GO:0035023|GO:0007266|GO:0048365 developmental process|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|cytoplasmic side of plasma membrane|cell development|multicellular organism development|dendrite development|cellular component assembly|enzyme binding|cytoplasm|Ras guanyl-nucleotide exchange factor activity|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|neuron projection|regulation of signal transduction|extrinsic component of plasma membrane|dendritic spine|somatodendritic compartment|regulation of cell communication|positive regulation of catalytic activity|cell communication|negative regulation of molecular function|signal transduction|synapse organization|cytoskeletal protein binding|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|synapse assembly|macromolecule modification|neuron spine|positive regulation of hydrolase activity|dendrite morphogenesis|cell morphogenesis involved in differentiation|protein modification process|negative regulation of cellular protein metabolic process|dendrite|negative regulation of hydrolase activity|filopodium|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|regulation of protein metabolic process|GTPase binding|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|regulation of intracellular signal transduction|cytoskeleton|neuron development|neuron differentiation|negative regulation of phosphatase activity|dephosphorylation|Rac guanyl-nucleotide exchange factor activity|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase binding|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|Ras protein signal transduction|regulation of Ras protein signal transduction|Ras GTPase binding|generation of neurons|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation|Rho GTPase binding|regulation of Rho protein signal transduction|Rho protein signal transduction|Rac GTPase binding - - - - 13:98142562-98455176 541 670 991 1338 1847 2500 0.8886244855475 1.00017539167055 1.46760511306343 1.96913260114717 2.48917953685239 3.84848870046822 1.11880166342716 2.76893361282259 -1.30737616054883 1.33015944652556e-06 1.61885772998672e-05 DOWN ENSG00000181220 ZNF746 zinc finger protein 746 [Source:HGNC Symbol;Acc:HGNC:21948] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0010941|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0010942|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0000981|GO:0009890|GO:0006139|GO:0008219|GO:0044249|GO:0031324|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:1901216|GO:0070997|GO:0010628|GO:1901214|GO:0010467|GO:0001227|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0044389|GO:0031625|GO:0000975|GO:0045893|GO:0001078|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell death|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of neuron death|neuron death|positive regulation of gene expression|regulation of neuron death|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|regulatory region DNA binding|positive regulation of transcription, DNA-templated|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 7:149472794-149497817 1123 1428 836 604 574 490 6.75546123594295 7.80698946062954 4.53414829099617 3.25544286166232 2.83305864956474 2.762488749605 6.36553299585622 2.95033008694402 1.10940494406772 1.33314122724898e-06 1.62182551745278e-05 UP ENSG00000136161 RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 [Source:HGNC Symbol;Acc:HGNC:1914] GO:0005623|GO:0008152|GO:0005488|GO:0043229|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0012505|GO:0005085|GO:0019222|GO:0031982|GO:0030141|GO:0043231|GO:0005737|GO:0005088|GO:0043085|GO:0001669|GO:0050790|GO:0031410|GO:0051345|GO:0005087|GO:0016023|GO:0031988|GO:0043087|GO:0043547 cell|metabolic process|binding|intracellular organelle|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|endomembrane system|guanyl-nucleotide exchange factor activity|regulation of metabolic process|vesicle|secretory granule|intracellular membrane-bounded organelle|cytoplasm|Ras guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|acrosomal vesicle|regulation of catalytic activity|cytoplasmic vesicle|positive regulation of hydrolase activity|Ran guanyl-nucleotide exchange factor activity|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|regulation of GTPase activity|positive regulation of GTPase activity - - - - 13:48488959-48533256 90 101 53 27 29 21 1.10679515110056 1.12883309016757 0.587645450851045 0.297505382697934 0.292607444786177 0.242027414192087 0.941091230706392 0.277380080558733 1.7624703992122 1.35655066898643e-06 1.64963192146317e-05 UP ENSG00000140694 PARN poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0019953|GO:0044237|GO:0043227|GO:0032504|GO:0016787|GO:0005622|GO:0005515|GO:0048609|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0006139|GO:0007276|GO:0000166|GO:0043487|GO:0005730|GO:0005829|GO:0010468|GO:0046872|GO:0003723|GO:0043412|GO:0044265|GO:0031981|GO:0004518|GO:0019900|GO:0010467|GO:0019439|GO:0016070|GO:0007292|GO:0005634|GO:0043488|GO:0006401|GO:0090501|GO:0010608|GO:0009451|GO:0004527|GO:0016071|GO:0004540|GO:0044822|GO:0090305|GO:0019901|GO:0004532|GO:0008408|GO:0003729|GO:0006402|GO:0090503|GO:0000956|GO:0003730|GO:0000175|GO:0016896|GO:0000184|GO:0000289|GO:0004535|GO:0000288 reproduction|cell|cellular process|reproductive process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|sexual reproduction|cellular metabolic process|membrane-bounded organelle|multicellular organism reproduction|hydrolase activity|intracellular|protein binding|multicellular organismal reproductive process|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|nucleobase-containing compound metabolic process|gamete generation|nucleotide binding|regulation of RNA stability|nucleolus|cytosol|regulation of gene expression|metal ion binding|RNA binding|macromolecule modification|cellular macromolecule catabolic process|nuclear lumen|nuclease activity|kinase binding|gene expression|aromatic compound catabolic process|RNA metabolic process|female gamete generation|nucleus|regulation of mRNA stability|RNA catabolic process|RNA phosphodiester bond hydrolysis|posttranscriptional regulation of gene expression|RNA modification|exonuclease activity|mRNA metabolic process|ribonuclease activity|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|protein kinase binding|exoribonuclease activity|3'-5' exonuclease activity|mRNA binding|mRNA catabolic process|RNA phosphodiester bond hydrolysis, exonucleolytic|nuclear-transcribed mRNA catabolic process|mRNA 3'-UTR binding|3'-5'-exoribonuclease activity|exoribonuclease activity, producing 5'-phosphomonoesters|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|poly(A)-specific ribonuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K01148 poly(A)-specific ribonuclease[3.1.13.4] hsa03018 RNA degradation - Homo sapiens (human) 16:14435701-14632728 501 637 560 1337 1384 1072 5.40230768754248 6.24253686722944 5.44432540262305 12.9172784565399 12.2446354468644 10.8334260171059 5.69638998579832 11.9984466401701 -1.07472781723065 1.37460801699043e-06 1.6695503555424e-05 DOWN ENSG00000162959 MEMO1 mediator of cell motility 1 [Source:HGNC Symbol;Acc:HGNC:14014] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0032886|GO:0016021|GO:0007017|GO:0005829|GO:0005634 cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|regulation of microtubule-based process|integral component of membrane|microtubule-based process|cytosol|nucleus - - - - 2:31865060-32011230 290 264 291 688 695 572 2.51979620541118 2.08473747068841 2.27968462331293 5.35616654890373 4.95473612166134 4.65793409840094 2.29473943313751 4.989612256322 -1.12059736240358 1.37456244318829e-06 1.6695503555424e-05 DOWN ENSG00000141527 CARD14 caspase recruitment domain family member 14 [Source:HGNC Symbol;Acc:HGNC:16446] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0071944|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0006725|GO:1901360|GO:0010941|GO:0034641|GO:0031325|GO:0046483|GO:0005737|GO:0009966|GO:0019904|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0051090|GO:1902533|GO:0032268|GO:0010468|GO:0034645|GO:0007166|GO:0043412|GO:0034097|GO:0043069|GO:0051252|GO:0010628|GO:0051347|GO:0036211|GO:0051091|GO:0051247|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0050700|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:1902531|GO:0016070|GO:0010557|GO:0043067|GO:0045893|GO:0019221|GO:0031401|GO:0038061|GO:0032774|GO:2001141|GO:0016310|GO:0051092|GO:1901222|GO:0042981|GO:0071345|GO:0043066|GO:0034612|GO:0006464|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:1901224|GO:0033674|GO:0045859|GO:0045860|GO:0006468|GO:0071356|GO:1903506|GO:0042325|GO:0001932|GO:0007250|GO:0033209|GO:0001934|GO:0042327|GO:0071902|GO:0071900|GO:0032147 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|cell periphery|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cytoplasm|regulation of signal transduction|protein domain specific binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|macromolecule modification|response to cytokine|negative regulation of programmed cell death|regulation of RNA metabolic process|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|CARD domain binding|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|positive regulation of protein modification process|NIK/NF-kappaB signaling|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorylation|positive regulation of NF-kappaB transcription factor activity|regulation of NIK/NF-kappaB signaling|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|response to tumor necrosis factor|cellular protein modification process|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of NIK/NF-kappaB signaling|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|activation of NF-kappaB-inducing kinase activity|tumor necrosis factor-mediated signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity - - - - 17:80169992-80209331 44 35 71 141 143 230 0.246332353907167 0.178083577160689 0.358380812761065 0.7072743716351 0.656860943484649 1.20677684124543 0.260932247942974 0.856970718788393 -1.71557065664823 1.3930637822345e-06 1.69059049409873e-05 DOWN ENSG00000116141 MARK1 MAP/microtubule affinity-regulating kinase 1 [Source:HGNC Symbol;Acc:HGNC:6896] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0072341|GO:0016043|GO:0008289|GO:0071944|GO:0005622|GO:0005886|GO:0016740|GO:0048856|GO:0007275|GO:0043168|GO:0005543|GO:0001882|GO:0016772|GO:0043169|GO:0005737|GO:0006928|GO:0043177|GO:0001786|GO:0007154|GO:0016477|GO:0007165|GO:0000166|GO:0048869|GO:0007017|GO:0019538|GO:0006996|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0007010|GO:0035091|GO:0001883|GO:0036211|GO:0001764|GO:0032549|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0031406|GO:0007399|GO:0017076|GO:0070300|GO:0030154|GO:0000226|GO:0016773|GO:0005856|GO:0016055|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0015630|GO:1901981|GO:0016597|GO:0004672|GO:0022008|GO:0006464|GO:0006468|GO:1902936|GO:0048699|GO:0004674|GO:0050321|GO:0005546 locomotion|developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|modified amino acid binding|cellular component organization|lipid binding|cell periphery|intracellular|plasma membrane|transferase activity|anatomical structure development|multicellular organism development|anion binding|phospholipid binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|cytoplasm|movement of cell or subcellular component|organic acid binding|phosphatidylserine binding|cell communication|cell migration|signal transduction|nucleotide binding|cellular developmental process|microtubule-based process|protein metabolic process|organelle organization|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|phosphatidylinositol binding|purine nucleoside binding|protein modification process|neuron migration|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|carboxylic acid binding|nervous system development|purine nucleotide binding|phosphatidic acid binding|cell differentiation|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|Wnt signaling pathway|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|phosphatidylinositol phosphate binding|amino acid binding|protein kinase activity|neurogenesis|cellular protein modification process|protein phosphorylation|phosphatidylinositol bisphosphate binding|generation of neurons|protein serine/threonine kinase activity|tau-protein kinase activity|phosphatidylinositol-4,5-bisphosphate binding - - - - 1:220528183-220664461 5 2 8 21 31 50 0.0350025675621251 0.0127238598870004 0.0504922727336673 0.131713591849333 0.178050913169599 0.328026756000823 0.0327395667275976 0.212597087006585 -2.69901469471945 1.40677060436014e-06 1.70514533587363e-05 DOWN ENSG00000257524 RP11-203J24.9 - - - - - - - 9:127867864-127886787 23 14 32 3 0 7 1.11436393098023 0.616453581580118 1.39782939420623 0.130212670352385 0 0.317856667393444 1.04288230225553 0.149356445915276 2.80374493934415 1.40797931144519e-06 1.70591779074207e-05 UP ENSG00000143199 ADCY10 adenylate cyclase 10 (soluble) [Source:HGNC Symbol;Acc:HGNC:21285] GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0045178|GO:0050794|GO:0043229|GO:0006807|GO:0016829|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0045177|GO:0044297|GO:0030427|GO:0043227|GO:0071944|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0005929|GO:0048609|GO:0004016|GO:0006725|GO:0043025|GO:1901360|GO:0010941|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0019637|GO:0046483|GO:0030426|GO:0010942|GO:0043231|GO:0031514|GO:0043169|GO:0019899|GO:0005737|GO:0006928|GO:0043005|GO:0016849|GO:0036477|GO:0006139|GO:0055086|GO:0007154|GO:0007276|GO:0007165|GO:0008219|GO:0000166|GO:0010035|GO:0044249|GO:0007017|GO:0005829|GO:0048232|GO:0046872|GO:0035639|GO:0030424|GO:0019693|GO:0001883|GO:0051117|GO:0032549|GO:0030425|GO:0007018|GO:0048471|GO:0005739|GO:0071890|GO:0012501|GO:0006796|GO:0035556|GO:0071241|GO:1901137|GO:0017076|GO:0043068|GO:0005856|GO:0005634|GO:0043067|GO:0007283|GO:0043065|GO:0009259|GO:0009117|GO:0000287|GO:0005524|GO:0046390|GO:0030554|GO:0015630|GO:0006163|GO:0042981|GO:0046914|GO:0009165|GO:0006915|GO:0003341|GO:0006164|GO:0003351|GO:0030145|GO:0009187|GO:0009190|GO:0046058|GO:0009152|GO:0052652|GO:0006171 reproduction|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|basal part of cell|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|lyase activity|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|apical part of cell|cell body|site of polarized growth|membrane-bounded organelle|cell periphery|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|plasma membrane|cilium|multicellular organismal reproductive process|adenylate cyclase activity|cellular aromatic compound metabolic process|neuronal cell body|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|organophosphate metabolic process|heterocycle metabolic process|growth cone|positive regulation of cell death|intracellular membrane-bounded organelle|motile cilium|cation binding|enzyme binding|cytoplasm|movement of cell or subcellular component|neuron projection|phosphorus-oxygen lyase activity|somatodendritic compartment|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|gamete generation|signal transduction|cell death|nucleotide binding|response to inorganic substance|cellular biosynthetic process|microtubule-based process|cytosol|male gamete generation|metal ion binding|purine ribonucleoside triphosphate binding|axon|ribose phosphate metabolic process|purine nucleoside binding|ATPase binding|ribonucleoside binding|dendrite|microtubule-based movement|perinuclear region of cytoplasm|mitochondrion|bicarbonate binding|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular response to inorganic substance|carbohydrate derivative biosynthetic process|purine nucleotide binding|positive regulation of programmed cell death|cytoskeleton|nucleus|regulation of programmed cell death|spermatogenesis|positive regulation of apoptotic process|ribonucleotide metabolic process|nucleotide metabolic process|magnesium ion binding|ATP binding|ribose phosphate biosynthetic process|adenyl nucleotide binding|microtubule cytoskeleton|purine nucleotide metabolic process|regulation of apoptotic process|transition metal ion binding|nucleotide biosynthetic process|apoptotic process|cilium movement|purine nucleotide biosynthetic process|epithelial cilium movement|manganese ion binding|cyclic nucleotide metabolic process|cyclic nucleotide biosynthetic process|cAMP metabolic process|purine ribonucleotide biosynthetic process|cyclic purine nucleotide metabolic process|cAMP biosynthetic process K11265 adenylate cyclase 10[4.6.1.1] hsa04024|hsa00230|hsa04713 cAMP signaling pathway - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human) 1:167809388-167914215 19 12 28 5 2 2 0.184586022042245 0.105953526294305 0.245257342062112 0.0435204235583232 0.0159412627138816 0.0182078685284214 0.178598963466221 0.0258898516002087 2.78626510662941 1.4128325355981e-06 1.71110355041565e-05 UP ENSG00000198814 GK glycerol kinase [Source:HGNC Symbol;Acc:HGNC:4289] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0043227|GO:0019867|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0031090|GO:0019222|GO:0044262|GO:0044255|GO:0042393|GO:0006082|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0031982|GO:0019637|GO:0043231|GO:0005737|GO:0005975|GO:0042592|GO:0031966|GO:0042493|GO:0006629|GO:0070062|GO:0042180|GO:0009409|GO:0000166|GO:0044249|GO:0009266|GO:0010033|GO:0031323|GO:0005740|GO:0005829|GO:0046486|GO:0035639|GO:0005741|GO:0048878|GO:0006066|GO:0006631|GO:0001883|GO:0044275|GO:0006071|GO:0032549|GO:0006638|GO:0005739|GO:0016052|GO:0016301|GO:0010565|GO:0006796|GO:1901137|GO:0008610|GO:0019216|GO:0017076|GO:0016773|GO:0005634|GO:0097305|GO:0019217|GO:0019563|GO:0004370|GO:0005524|GO:0046164|GO:0030554|GO:0016310|GO:0045471|GO:0006072|GO:0019752|GO:0006639|GO:0046167|GO:0033500|GO:0042593|GO:0032787|GO:0006641|GO:0019432 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|outer membrane|biosynthetic process|intracellular|protein binding|transferase activity|organelle membrane|regulation of metabolic process|cellular carbohydrate metabolic process|cellular lipid metabolic process|histone binding|organic acid metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|homeostatic process|mitochondrial membrane|response to drug|lipid metabolic process|extracellular exosome|cellular ketone metabolic process|response to cold|nucleotide binding|cellular biosynthetic process|response to temperature stimulus|response to organic substance|regulation of cellular metabolic process|mitochondrial envelope|cytosol|glycerolipid metabolic process|purine ribonucleoside triphosphate binding|mitochondrial outer membrane|chemical homeostasis|alcohol metabolic process|fatty acid metabolic process|purine nucleoside binding|cellular carbohydrate catabolic process|glycerol metabolic process|ribonucleoside binding|neutral lipid metabolic process|mitochondrion|carbohydrate catabolic process|kinase activity|regulation of cellular ketone metabolic process|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|lipid biosynthetic process|regulation of lipid metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|response to alcohol|regulation of fatty acid metabolic process|glycerol catabolic process|glycerol kinase activity|ATP binding|alcohol catabolic process|adenyl nucleotide binding|phosphorylation|response to ethanol|glycerol-3-phosphate metabolic process|carboxylic acid metabolic process|acylglycerol metabolic process|glycerol-3-phosphate biosynthetic process|carbohydrate homeostasis|glucose homeostasis|monocarboxylic acid metabolic process|triglyceride metabolic process|triglyceride biosynthetic process K00864 glycerol kinase[2.7.1.30] hsa01100|hsa03320|hsa00561 Metabolic pathways - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Glycerolipid metabolism - Homo sapiens (human) X:30653359-30731456 36 46 42 122 123 112 0.271833986766838 0.315672064009094 0.285932049050836 0.825385092355428 0.762029948909254 0.792583283524728 0.291146033275589 0.793332774929803 -1.44618318934743 1.41363240143833e-06 1.71137800942984e-05 DOWN ENSG00000213024 NUP62 nucleoporin 62kDa [Source:HGNC Symbol;Acc:HGNC:8066] GO:0032502|GO:0032991|GO:0000003|GO:0005215|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0030496|GO:0005642|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0005487|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0042175|GO:0071704|GO:0009628|GO:0032947|GO:0017056|GO:0019953|GO:0044237|GO:0051641|GO:0090543|GO:0023051|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0048609|GO:0019222|GO:0016032|GO:0060341|GO:0042127|GO:0007049|GO:0032182|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0010941|GO:0030159|GO:0005102|GO:0034641|GO:0044281|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0043231|GO:0031074|GO:0005737|GO:0030529|GO:0032880|GO:0009408|GO:0005975|GO:0005635|GO:0009966|GO:0045184|GO:0003682|GO:0019904|GO:0060548|GO:0046930|GO:0016458|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0044092|GO:0055085|GO:0061024|GO:0007276|GO:0007165|GO:0009968|GO:0051649|GO:0008134|GO:0008092|GO:0009725|GO:0006403|GO:0008219|GO:0008285|GO:0031965|GO:0050790|GO:0031072|GO:0043086|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0009266|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0010256|GO:0006996|GO:0007568|GO:0051701|GO:1900034|GO:0000165|GO:0019048|GO:1902533|GO:0032268|GO:0006998|GO:0010468|GO:0034645|GO:0019054|GO:0048232|GO:0007166|GO:0051879|GO:1903047|GO:0043412|GO:0072594|GO:0034097|GO:0031047|GO:0010629|GO:0051427|GO:0043069|GO:0043130|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0010628|GO:0051425|GO:0036211|GO:0032269|GO:0000278|GO:0070201|GO:0046907|GO:0030544|GO:0019083|GO:0007569|GO:1901184|GO:0034605|GO:1901185|GO:0006461|GO:0034613|GO:0046966|GO:0012501|GO:0050658|GO:0006796|GO:0035556|GO:0042169|GO:0044267|GO:0051174|GO:0007067|GO:0010467|GO:0017038|GO:0019894|GO:0019058|GO:0071310|GO:1902532|GO:0006997|GO:0031328|GO:0051246|GO:0009059|GO:0009755|GO:1903827|GO:1902531|GO:0016070|GO:0008643|GO:0032870|GO:0005856|GO:1901186|GO:0010557|GO:0000922|GO:0005634|GO:0005819|GO:0043067|GO:0006606|GO:0005643|GO:0010827|GO:0007283|GO:1904589|GO:0045893|GO:0007077|GO:0019221|GO:0033365|GO:0033157|GO:0043122|GO:0045742|GO:0051028|GO:0051169|GO:0006396|GO:0051259|GO:0043408|GO:0042058|GO:0032774|GO:0034660|GO:2001141|GO:0035257|GO:0016310|GO:0006605|GO:0016482|GO:0006886|GO:0007167|GO:0043123|GO:0015630|GO:0042059|GO:0051081|GO:0007249|GO:0042981|GO:0071345|GO:0043066|GO:0043409|GO:0033673|GO:0042306|GO:0051056|GO:1900180|GO:0007264|GO:0006464|GO:0051058|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:1903533|GO:0007265|GO:0006913|GO:0046578|GO:0045859|GO:0008645|GO:0006469|GO:0006468|GO:0043407|GO:0051291|GO:1903506|GO:0043405|GO:0042325|GO:0070206|GO:0006399|GO:0001932|GO:0018193|GO:0042326|GO:0043687|GO:0001933|GO:0034504|GO:0046822|GO:0046580|GO:0007169|GO:0008033|GO:0032446|GO:0051170|GO:0015758|GO:0071901|GO:0070208|GO:0071900|GO:0018205|GO:0038127|GO:0007173|GO:0016925 developmental process|macromolecular complex|reproduction|transporter activity|structural molecule activity|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|midbody|annulate lamellae|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|nucleocytoplasmic transporter activity|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|response to abiotic stimulus|protein complex scaffold|structural constituent of nuclear pore|sexual reproduction|cellular metabolic process|cellular localization|Flemming body|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|viral process|regulation of cellular localization|regulation of cell proliferation|cell cycle|ubiquitin-like protein binding|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|receptor signaling complex scaffold activity|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|nucleocytoplasmic shuttling complex|cytoplasm|intracellular ribonucleoprotein complex|regulation of protein localization|response to heat|carbohydrate metabolic process|nuclear envelope|regulation of signal transduction|establishment of protein localization|chromatin binding|protein domain specific binding|negative regulation of cell death|pore complex|gene silencing|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|negative regulation of molecular function|transmembrane transport|membrane organization|gamete generation|signal transduction|negative regulation of signal transduction|establishment of localization in cell|transcription factor binding|cytoskeletal protein binding|response to hormone|RNA localization|cell death|negative regulation of cell proliferation|nuclear membrane|regulation of catalytic activity|heat shock protein binding|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endomembrane system organization|organelle organization|aging|interaction with host|regulation of cellular response to heat|MAPK cascade|modulation by virus of host morphology or physiology|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|nuclear envelope organization|regulation of gene expression|cellular macromolecule biosynthetic process|modulation by virus of host process|male gamete generation|cell surface receptor signaling pathway|Hsp90 protein binding|mitotic cell cycle process|macromolecule modification|establishment of protein localization to organelle|response to cytokine|gene silencing by RNA|negative regulation of gene expression|hormone receptor binding|negative regulation of programmed cell death|ubiquitin binding|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|positive regulation of gene expression|PTB domain binding|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of establishment of protein localization|intracellular transport|Hsp70 protein binding|viral transcription|cell aging|regulation of ERBB signaling pathway|cellular response to heat|negative regulation of ERBB signaling pathway|protein complex assembly|cellular protein localization|thyroid hormone receptor binding|programmed cell death|RNA transport|phosphate-containing compound metabolic process|intracellular signal transduction|SH2 domain binding|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|gene expression|protein import|kinesin binding|viral life cycle|cellular response to organic substance|negative regulation of intracellular signal transduction|nucleus organization|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|carbohydrate transport|cellular response to hormone stimulus|cytoskeleton|positive regulation of ERBB signaling pathway|positive regulation of macromolecule biosynthetic process|spindle pole|nucleus|spindle|regulation of programmed cell death|protein import into nucleus|nuclear pore|regulation of glucose transport|spermatogenesis|regulation of protein import|positive regulation of transcription, DNA-templated|mitotic nuclear envelope disassembly|cytokine-mediated signaling pathway|protein localization to organelle|regulation of intracellular protein transport|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of epidermal growth factor receptor signaling pathway|mRNA transport|nuclear transport|RNA processing|protein oligomerization|regulation of MAPK cascade|regulation of epidermal growth factor receptor signaling pathway|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|phosphorylation|protein targeting|cytosolic transport|intracellular protein transport|enzyme linked receptor protein signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|microtubule cytoskeleton|negative regulation of epidermal growth factor receptor signaling pathway|nuclear envelope disassembly|I-kappaB kinase/NF-kappaB signaling|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|negative regulation of MAPK cascade|negative regulation of kinase activity|regulation of protein import into nucleus|regulation of small GTPase mediated signal transduction|regulation of protein localization to nucleus|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of protein targeting|Ras protein signal transduction|nucleocytoplasmic transport|regulation of Ras protein signal transduction|regulation of protein kinase activity|hexose transport|negative regulation of protein kinase activity|protein phosphorylation|negative regulation of MAP kinase activity|protein heterooligomerization|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|protein trimerization|tRNA metabolic process|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|post-translational protein modification|negative regulation of protein phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|negative regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|tRNA processing|protein modification by small protein conjugation|nuclear import|glucose transport|negative regulation of protein serine/threonine kinase activity|protein heterotrimerization|regulation of protein serine/threonine kinase activity|peptidyl-lysine modification|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|protein sumoylation K14306 nuclear pore complex protein Nup62[-] hsa03013 RNA transport - Homo sapiens (human) 19:49906825-49929763 3761 3921 3010 1851 2268 1453 12.6970499649224 12.0302985788798 9.16178735186261 5.59891256169571 6.28218190626901 4.59720884431315 11.2963786318883 5.49276777075929 1.04025514834755 1.42195375832245e-06 1.71936036860909e-05 UP ENSG00000117472 TSPAN1 tetraspanin 1 [Source:HGNC Symbol;Acc:HGNC:20657] GO:0040011|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0051050|GO:0048870|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0031090|GO:0006810|GO:0051130|GO:0060627|GO:0031982|GO:0051128|GO:0045807|GO:0005887|GO:0043231|GO:0005774|GO:0005737|GO:0006928|GO:0031226|GO:0007154|GO:0016477|GO:0007165|GO:0070062|GO:0031647|GO:0016021|GO:0016192|GO:0007166|GO:0050821|GO:0005773|GO:0030100|GO:0048471|GO:0000323|GO:0006897|GO:0005765|GO:0005764 locomotion|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|positive regulation of transport|cell motility|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|organelle membrane|transport|positive regulation of cellular component organization|regulation of vesicle-mediated transport|vesicle|regulation of cellular component organization|positive regulation of endocytosis|integral component of plasma membrane|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|movement of cell or subcellular component|intrinsic component of plasma membrane|cell communication|cell migration|signal transduction|extracellular exosome|regulation of protein stability|integral component of membrane|vesicle-mediated transport|cell surface receptor signaling pathway|protein stabilization|vacuole|regulation of endocytosis|perinuclear region of cytoplasm|lytic vacuole|endocytosis|lysosomal membrane|lysosome - - - - 1:46175073-46185958 1261 1444 1924 2991 3293 3777 17.8684223130894 18.5959507012836 24.580482395973 37.9739083303173 38.2851915304061 50.1587962264264 20.348285136782 42.1392986957166 -1.05025908859296 1.42272353985429e-06 1.71959467849433e-05 DOWN ENSG00000154122 ANKH ANKH inorganic pyrophosphate transport regulator [Source:HGNC Symbol;Acc:HGNC:15492] GO:0032502|GO:0005215|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0019867|GO:0071944|GO:0031224|GO:0050793|GO:0005886|GO:0007626|GO:0048856|GO:0009888|GO:0006810|GO:0007275|GO:0048513|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0030278|GO:0001503|GO:0016021|GO:0031214|GO:0006811|GO:0015075|GO:0005315|GO:0001501|GO:0030282|GO:0030500|GO:0034220|GO:0006820|GO:0098656|GO:0008509|GO:0015698|GO:0030504|GO:0030505|GO:0035435|GO:0006817|GO:0015114 developmental process|transporter activity|behavior|cell|membrane|cellular process|transmembrane transporter activity|outer membrane|cell periphery|intrinsic component of membrane|regulation of developmental process|plasma membrane|locomotory behavior|anatomical structure development|tissue development|transport|multicellular organism development|animal organ development|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|regulation of ossification|ossification|integral component of membrane|biomineral tissue development|ion transport|ion transmembrane transporter activity|inorganic phosphate transmembrane transporter activity|skeletal system development|bone mineralization|regulation of bone mineralization|ion transmembrane transport|anion transport|anion transmembrane transport|anion transmembrane transporter activity|inorganic anion transport|inorganic diphosphate transmembrane transporter activity|inorganic diphosphate transport|phosphate ion transmembrane transport|phosphate ion transport|phosphate ion transmembrane transporter activity - - - - 5:14704804-14871778 160 215 302 489 543 662 0.920453819071047 1.12408916490386 1.5664040716112 2.52050902523125 2.56300684634458 3.56918215245452 1.2036490185287 2.88423267467678 -1.2607727866537 1.42372367079909e-06 1.72010710109413e-05 DOWN ENSG00000164542 KIAA0895 KIAA0895 [Source:HGNC Symbol;Acc:HGNC:22206] - - - - - - 7:36324221-36390125 499 569 568 242 284 335 2.00202321504069 2.07472663533823 2.0546196504555 0.869925323870321 0.934879804287121 1.2596305014776 2.04378983361147 1.02147854321168 1.00058794942713 1.4328112348472e-06 1.72968647816936e-05 UP ENSG00000230650 AC112229.1 - - - - - - - 2:110360608-110363737 369 404 301 130 181 184 8.33926854805991 8.29780539592965 6.13312876624848 2.63234963771257 3.35620151039968 3.89716566070574 7.59006757007935 3.29523893627266 1.20372965101036 1.44293728226063e-06 1.7412065329268e-05 UP ENSG00000155858 LSM11 LSM11, U7 small nuclear RNA associated [Source:HGNC Symbol;Acc:HGNC:30860] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0045787|GO:0006139|GO:0044249|GO:0034645|GO:0090068|GO:0003723|GO:1903047|GO:0030532|GO:0044770|GO:0000278|GO:0031981|GO:0007346|GO:0071204|GO:0010564|GO:0005654|GO:0005697|GO:0010467|GO:0009059|GO:0016070|GO:0045931|GO:0005634|GO:0017069|GO:0006396|GO:0032774|GO:0044772|GO:1901990|GO:1901989|GO:1901992|GO:0016071|GO:0005683|GO:1901987|GO:0006351|GO:1900087|GO:2000045|GO:0006366|GO:1902808|GO:0008334|GO:1902806|GO:0006397|GO:0000082|GO:0071209|GO:0006353|GO:0031123|GO:0031124|GO:0006369|GO:0006398 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|positive regulation of cell cycle|nucleobase-containing compound metabolic process|cellular biosynthetic process|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|RNA binding|mitotic cell cycle process|small nuclear ribonucleoprotein complex|cell cycle phase transition|mitotic cell cycle|nuclear lumen|regulation of mitotic cell cycle|histone pre-mRNA 3'end processing complex|regulation of cell cycle process|nucleoplasm|telomerase holoenzyme complex|gene expression|macromolecule biosynthetic process|RNA metabolic process|positive regulation of mitotic cell cycle|nucleus|snRNA binding|RNA processing|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of mitotic cell cycle phase transition|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|mRNA metabolic process|U7 snRNP|regulation of cell cycle phase transition|transcription, DNA-templated|positive regulation of G1/S transition of mitotic cell cycle|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|positive regulation of cell cycle G1/S phase transition|histone mRNA metabolic process|regulation of cell cycle G1/S phase transition|mRNA processing|G1/S transition of mitotic cell cycle|U7 snRNA binding|DNA-templated transcription, termination|RNA 3'-end processing|mRNA 3'-end processing|termination of RNA polymerase II transcription|mRNA 3'-end processing by stem-loop binding and cleavage - - - - 5:157743695-157760709 311 425 544 189 231 217 3.34130697472467 4.14977730988189 5.26949055426182 1.81934452829791 2.0362687480395 2.18496965104424 4.25352494628946 2.01352764246055 1.07893363703811 1.45664931147348e-06 1.75704276948401e-05 UP ENSG00000155085 AK9 adenylate kinase 9 [Source:HGNC Symbol;Acc:HGNC:33814] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0005635|GO:0006139|GO:0055086|GO:0031965|GO:0000166|GO:0006091|GO:0044249|GO:0005829|GO:0009262|GO:0035639|GO:0015949|GO:0019693|GO:0001883|GO:0009116|GO:0032549|GO:0031981|GO:0005654|GO:0016301|GO:0006796|GO:1901137|GO:0017076|GO:0005634|GO:0016776|GO:0006757|GO:0009142|GO:0009124|GO:0009259|GO:0009117|GO:0005524|GO:0046390|GO:0004550|GO:0030554|GO:0016310|GO:0019205|GO:0009132|GO:0006163|GO:0050145|GO:0009165|GO:0042278|GO:0006164|GO:0046939|GO:0046940|GO:0009200|GO:0009186|GO:0006165|GO:0009156|GO:0061567|GO:0006186|GO:0006756|GO:0046034|GO:0006174|GO:0061566|GO:0009152|GO:0061568|GO:0046031|GO:0046033|GO:0061571|GO:0009168|GO:0061570|GO:0061508|GO:0061565|GO:0061569|GO:0006754 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|endomembrane system|transferase activity|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|nuclear membrane|nucleotide binding|generation of precursor metabolites and energy|cellular biosynthetic process|cytosol|deoxyribonucleotide metabolic process|purine ribonucleoside triphosphate binding|nucleobase-containing small molecule interconversion|ribose phosphate metabolic process|purine nucleoside binding|nucleoside metabolic process|ribonucleoside binding|nuclear lumen|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|purine nucleotide binding|nucleus|phosphotransferase activity, phosphate group as acceptor|ATP generation from ADP|nucleoside triphosphate biosynthetic process|nucleoside monophosphate biosynthetic process|ribonucleotide metabolic process|nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|nucleoside diphosphate kinase activity|adenyl nucleotide binding|phosphorylation|nucleobase-containing compound kinase activity|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|nucleoside phosphate kinase activity|nucleotide biosynthetic process|purine nucleoside metabolic process|purine nucleotide biosynthetic process|nucleotide phosphorylation|nucleoside monophosphate phosphorylation|deoxyribonucleoside triphosphate metabolic process|deoxyribonucleoside diphosphate metabolic process|nucleoside diphosphate phosphorylation|ribonucleoside monophosphate biosynthetic process|dCMP phosphorylation|dGDP phosphorylation|AMP phosphorylation|ATP metabolic process|dADP phosphorylation|CMP phosphorylation|purine ribonucleotide biosynthetic process|GDP phosphorylation|ADP metabolic process|AMP metabolic process|TDP phosphorylation|purine ribonucleoside monophosphate biosynthetic process|dCDP phosphorylation|CDP phosphorylation|dAMP phosphorylation|UDP phosphorylation|ATP biosynthetic process K18533 adenylate/nucleoside-diphosphate kinase[2.7.4.6] hsa01100|hsa00230|hsa00240 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human) 6:109492856-109691217 23 14 38 82 84 142 0.116154161435792 0.0642551744918236 0.173020577391403 0.371031452782488 0.348055882667524 0.672076435239009 0.11780997110634 0.46372125689634 -1.97679621109331 1.4614662465606e-06 1.76214108743215e-05 DOWN ENSG00000105854 PON2 paraoxonase 2 [Source:HGNC Symbol;Acc:HGNC:9205] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0043229|GO:0006950|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0042802|GO:0006725|GO:0016788|GO:0043231|GO:0043169|GO:0005737|GO:0006979|GO:0016021|GO:0009636|GO:0046872|GO:0005773|GO:0005739|GO:0019439|GO:0005634|GO:0052689|GO:0000323|GO:0004064|GO:0005764 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|intracellular organelle|response to stress|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|plasma membrane|identical protein binding|cellular aromatic compound metabolic process|hydrolase activity, acting on ester bonds|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to oxidative stress|integral component of membrane|response to toxic substance|metal ion binding|vacuole|mitochondrion|aromatic compound catabolic process|nucleus|carboxylic ester hydrolase activity|lytic vacuole|arylesterase activity|lysosome K01045 arylesterase / paraoxonase[3.1.8.1] hsa01100 Metabolic pathways - Homo sapiens (human) 7:95404863-95435329 432 553 623 1170 1298 982 3.18581012026002 3.70630822293404 4.14227395688799 7.73072320055534 7.85378663981306 6.78698727105565 3.67813076669402 7.45716570380802 -1.0196546275874 1.46817367515374e-06 1.76951380290834e-05 DOWN ENSG00000157657 ZNF618 zinc finger protein 618 [Source:HGNC Symbol;Acc:HGNC:29416] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 9:113876282-114056591 0 0 0 6 13 7 0 0 0 0.0302101299365275 0.0599359096363983 0.0368661212578987 0 0.0423373869436082 -Inf 1.47797814287524e-06 1.78061176260684e-05 DOWN ENSG00000146776 ATXN7L1 ataxin 7-like 1 [Source:HGNC Symbol;Acc:HGNC:22210] GO:0005488|GO:0005515 binding|protein binding - - - - 7:105605067-105876604 17 38 55 136 129 115 0.0932751862079782 0.18949096175959 0.272082899262227 0.668591014851791 0.580740115020261 0.591362701903755 0.184949682409932 0.613564610591936 -1.73008244982757 1.49344370241065e-06 1.79851828526695e-05 DOWN ENSG00000158717 RNF166 ring finger protein 166 [Source:HGNC Symbol;Acc:HGNC:28856] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0009893|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0031325|GO:0043169|GO:0019899|GO:0019787|GO:0019538|GO:0031323|GO:0032268|GO:0045732|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:0051247|GO:0006508|GO:0032270|GO:0044267|GO:0044390|GO:0042176|GO:0051246|GO:0044257|GO:0061630|GO:0010498|GO:1903364|GO:0030162|GO:0045862|GO:0051603|GO:0046914|GO:0031624|GO:0006464|GO:1903052|GO:0019941|GO:1901800|GO:0061136|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0032436|GO:0016567|GO:0000209 cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|positive regulation of metabolic process|intracellular|protein binding|transferase activity|regulation of metabolic process|positive regulation of cellular metabolic process|cation binding|enzyme binding|ubiquitin-like protein transferase activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|positive regulation of protein metabolic process|proteolysis|positive regulation of cellular protein metabolic process|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein catabolic process|regulation of protein metabolic process|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|positive regulation of cellular protein catabolic process|regulation of proteolysis|positive regulation of proteolysis|proteolysis involved in cellular protein catabolic process|transition metal ion binding|ubiquitin conjugating enzyme binding|cellular protein modification process|positive regulation of proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|regulation of proteasomal protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 16:88696495-88706421 546 574 453 240 320 233 3.88984937207356 3.71648426253415 2.90972806409943 1.53196612749964 1.87050177065565 1.5557007898096 3.50535389956905 1.6527228959883 1.08471525044124 1.49518729200775e-06 1.79989199256449e-05 UP ENSG00000196290 NIF3L1 NGG1 interacting factor 3 like 1 [Source:HGNC Symbol;Acc:HGNC:13390] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0042802|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0009890|GO:0006139|GO:0008134|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010628|GO:0005739|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0010557|GO:0005634|GO:0030182|GO:0045893|GO:0032774|GO:2001141|GO:1902679|GO:0022008|GO:0006351|GO:0006355|GO:1903507|GO:0048699|GO:1903506 developmental process|cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|transcription factor binding|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|positive regulation of gene expression|mitochondrion|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|neuron differentiation|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|generation of neurons|regulation of nucleic acid-templated transcription - - - - 2:200889327-200903930 232 267 296 627 647 523 2.56943506111806 2.68744951930005 2.95566559457508 6.22177550667582 5.87923788801059 5.42849802271355 2.73751672499773 5.84317047246665 -1.09388360106359 1.49992799553789e-06 1.80487103501766e-05 DOWN ENSG00000187764 SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D [Source:HGNC Symbol;Acc:HGNC:10732] GO:0040011|GO:0032502|GO:0040007|GO:0004871|GO:0045499|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0004872|GO:0009892|GO:0048523|GO:0048521|GO:0050794|GO:0040012|GO:0006807|GO:0016049|GO:0071704|GO:0006955|GO:0044237|GO:0050795|GO:0038023|GO:0048870|GO:0023051|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0045927|GO:0007155|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0050793|GO:0048589|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0051272|GO:0016337|GO:0008360|GO:0006935|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0051130|GO:1901360|GO:0010941|GO:0007275|GO:0045596|GO:0048513|GO:0030279|GO:0032535|GO:0005102|GO:0016358|GO:0034641|GO:0030307|GO:0030155|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0098609|GO:0005887|GO:0045597|GO:0004888|GO:0030308|GO:0050920|GO:0006928|GO:0009966|GO:0009890|GO:0048639|GO:0060548|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0007162|GO:0007154|GO:0044092|GO:0051270|GO:0061383|GO:0016477|GO:0007165|GO:0048588|GO:0030278|GO:0048638|GO:0001503|GO:0050922|GO:0008219|GO:0051271|GO:0060348|GO:0048640|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0001558|GO:0031324|GO:0031323|GO:0060560|GO:0043931|GO:0050768|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0048668|GO:0031344|GO:0010468|GO:0048672|GO:0034645|GO:0045668|GO:0007166|GO:0048670|GO:0043412|GO:0050773|GO:0051345|GO:0010629|GO:0010720|GO:0043069|GO:0048813|GO:0051252|GO:0070977|GO:0010721|GO:0045667|GO:0031346|GO:0000904|GO:0050919|GO:0061430|GO:0030334|GO:0001667|GO:0036211|GO:0030517|GO:0032269|GO:0001649|GO:0031345|GO:0060485|GO:0050769|GO:0008361|GO:0007159|GO:0051247|GO:0051346|GO:0022604|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0048864|GO:0010467|GO:0030516|GO:0032990|GO:0030215|GO:0007399|GO:0097485|GO:0051246|GO:0010770|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0030335|GO:1902531|GO:0016070|GO:1902667|GO:0043067|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:1900220|GO:0007411|GO:0001755|GO:0048863|GO:0010923|GO:0016311|GO:0010975|GO:0031401|GO:0010769|GO:0045892|GO:0048841|GO:0014068|GO:0032774|GO:2001141|GO:0014031|GO:0043087|GO:0016310|GO:1902679|GO:0070486|GO:0061564|GO:0048017|GO:0043547|GO:0048814|GO:0042981|GO:0043066|GO:0048762|GO:0014066|GO:0045665|GO:0071526|GO:0050772|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048843|GO:0048812|GO:0010976|GO:0010977|GO:0006351|GO:0006915|GO:0006355|GO:0050771|GO:0048675|GO:0010921|GO:0045666|GO:0014033|GO:0006470|GO:0035304|GO:0014032|GO:0006366|GO:1903507|GO:0048015|GO:0006357|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0042325|GO:0010693|GO:0001932|GO:0018193|GO:0042326|GO:0001934|GO:0035305|GO:0001933|GO:0000122|GO:0048846|GO:0050770|GO:0045664|GO:0042327|GO:0035303|GO:0035308|GO:0050731|GO:0050730|GO:0014065|GO:0050732|GO:0018108 locomotion|developmental process|growth|signal transducer activity|chemorepellent activity|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|negative regulation of behavior|regulation of cellular process|regulation of locomotion|nitrogen compound metabolic process|cell growth|organic substance metabolic process|immune response|cellular metabolic process|regulation of behavior|signaling receptor activity|cell motility|regulation of signaling|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell adhesion|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|regulation of developmental process|developmental growth|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|positive regulation of cellular component movement|single organismal cell-cell adhesion|regulation of cell shape|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|animal organ development|negative regulation of ossification|regulation of cellular component size|receptor binding|dendrite development|cellular nitrogen compound metabolic process|positive regulation of cell growth|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cell-cell adhesion|integral component of plasma membrane|positive regulation of cell differentiation|transmembrane signaling receptor activity|negative regulation of cell growth|regulation of chemotaxis|movement of cell or subcellular component|regulation of signal transduction|negative regulation of biosynthetic process|positive regulation of developmental growth|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|negative regulation of cell adhesion|cell communication|negative regulation of molecular function|regulation of cellular component movement|trabecula morphogenesis|cell migration|signal transduction|developmental cell growth|regulation of ossification|regulation of developmental growth|ossification|negative regulation of chemotaxis|cell death|negative regulation of cellular component movement|bone development|negative regulation of developmental growth|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|developmental growth involved in morphogenesis|ossification involved in bone maturation|negative regulation of neurogenesis|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|collateral sprouting|regulation of cell projection organization|regulation of gene expression|positive regulation of collateral sprouting|cellular macromolecule biosynthetic process|negative regulation of osteoblast differentiation|cell surface receptor signaling pathway|regulation of collateral sprouting|macromolecule modification|regulation of dendrite development|positive regulation of hydrolase activity|negative regulation of gene expression|positive regulation of cell development|negative regulation of programmed cell death|dendrite morphogenesis|regulation of RNA metabolic process|bone maturation|negative regulation of cell development|regulation of osteoblast differentiation|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|negative chemotaxis|bone trabecula morphogenesis|regulation of cell migration|ameboidal-type cell migration|protein modification process|negative regulation of axon extension|negative regulation of cellular protein metabolic process|osteoblast differentiation|negative regulation of cell projection organization|mesenchyme development|positive regulation of neurogenesis|regulation of cell size|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|negative regulation of hydrolase activity|regulation of cell morphogenesis|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|gene expression|regulation of axon extension|cell part morphogenesis|semaphorin receptor binding|nervous system development|neuron projection guidance|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|positive regulation of cell migration|regulation of intracellular signal transduction|RNA metabolic process|regulation of axon guidance|regulation of programmed cell death|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis|axon guidance|neural crest cell migration|stem cell differentiation|negative regulation of phosphatase activity|dephosphorylation|regulation of neuron projection development|positive regulation of protein modification process|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|regulation of axon extension involved in axon guidance|positive regulation of phosphatidylinositol 3-kinase signaling|RNA biosynthetic process|regulation of RNA biosynthetic process|mesenchymal cell development|regulation of GTPase activity|phosphorylation|negative regulation of RNA biosynthetic process|leukocyte aggregation|axon development|inositol lipid-mediated signaling|positive regulation of GTPase activity|regulation of dendrite morphogenesis|regulation of apoptotic process|negative regulation of apoptotic process|mesenchymal cell differentiation|regulation of phosphatidylinositol 3-kinase signaling|negative regulation of neuron differentiation|semaphorin-plexin signaling pathway|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|negative regulation of axon extension involved in axon guidance|neuron projection morphogenesis|positive regulation of neuron projection development|negative regulation of neuron projection development|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|negative regulation of axonogenesis|axon extension|regulation of phosphatase activity|positive regulation of neuron differentiation|neural crest cell differentiation|protein dephosphorylation|regulation of protein dephosphorylation|neural crest cell development|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|phosphatidylinositol-mediated signaling|regulation of transcription from RNA polymerase II promoter|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of phosphorylation|negative regulation of alkaline phosphatase activity|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|positive regulation of protein phosphorylation|negative regulation of dephosphorylation|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|axon extension involved in axon guidance|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|phosphatidylinositol 3-kinase signaling|negative regulation of peptidyl-tyrosine phosphorylation|peptidyl-tyrosine phosphorylation K06521 semaphorin 4[-] hsa04360 Axon guidance - Homo sapiens (human) 9:89360787-89498130 123 191 228 446 427 471 0.29464793724109 0.415825294515904 0.492431012398939 0.95725891460827 0.839253068180933 1.05741931697408 0.400968081385311 0.951310433254428 -1.24642880351009 1.52348370173182e-06 1.8317391232985e-05 DOWN ENSG00000177189 RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 [Source:HGNC Symbol;Acc:HGNC:10432] GO:0040011|GO:0032502|GO:0040007|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0009653|GO:0016043|GO:0051707|GO:0045927|GO:0043227|GO:0040008|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0002757|GO:0007049|GO:0004857|GO:0006935|GO:0045087|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0010941|GO:0007275|GO:0043028|GO:0034641|GO:0043168|GO:0030307|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0045597|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0002218|GO:0007267|GO:0006928|GO:0060548|GO:0006139|GO:0009617|GO:0050776|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0008219|GO:0050790|GO:0000166|GO:0030030|GO:0043086|GO:0048869|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0000165|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0010468|GO:0034645|GO:0043555|GO:0006518|GO:0046872|GO:0007166|GO:0033993|GO:0035639|GO:0043412|GO:0002758|GO:0007417|GO:0002237|GO:0030414|GO:0043620|GO:0043069|GO:0051252|GO:0001883|GO:0000904|GO:0010628|GO:0036211|GO:0032269|GO:0032549|GO:0031981|GO:0031098|GO:0051346|GO:0070848|GO:0006508|GO:0005654|GO:0002764|GO:0016301|GO:0019900|GO:0012501|GO:0006796|GO:0043603|GO:0035556|GO:0044267|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0017076|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0043027|GO:0016070|GO:0016773|GO:0010557|GO:0032496|GO:0005634|GO:0043067|GO:0045089|GO:0045088|GO:0048666|GO:0030182|GO:0007411|GO:0004866|GO:0010466|GO:0045893|GO:0043043|GO:0000287|GO:0032774|GO:0005524|GO:0030162|GO:2001141|GO:0071363|GO:0030554|GO:0016310|GO:0010608|GO:0038179|GO:0052547|GO:0002221|GO:0061564|GO:0006412|GO:0007167|GO:0006417|GO:0042981|GO:0045861|GO:0043066|GO:0004672|GO:0019901|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0051403|GO:0006351|GO:0006915|GO:0006355|GO:0004869|GO:0048011|GO:0045944|GO:0006366|GO:0002224|GO:0006357|GO:0007409|GO:0043281|GO:0006468|GO:0048699|GO:1903506|GO:0010951|GO:0004674|GO:0043154|GO:0007268|GO:0007169|GO:0052548|GO:2000117|GO:0034166|GO:0034134|GO:0038124|GO:0002756|GO:0034138|GO:0002755|GO:0034146|GO:2000116|GO:0034142|GO:0038123|GO:0034162|GO:0035666 locomotion|developmental process|growth|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|organic substance metabolic process|ion binding|immune response|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|response to other organism|positive regulation of growth|membrane-bounded organelle|regulation of growth|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|immune response-activating signal transduction|cell cycle|enzyme inhibitor activity|chemotaxis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|cysteine-type endopeptidase regulator activity involved in apoptotic process|cellular nitrogen compound metabolic process|anion binding|positive regulation of cell growth|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|activation of innate immune response|cell-cell signaling|movement of cell or subcellular component|negative regulation of cell death|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|cell death|regulation of catalytic activity|nucleotide binding|cell projection organization|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of translation in response to stress|peptide metabolic process|metal ion binding|cell surface receptor signaling pathway|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|central nervous system development|response to molecule of bacterial origin|peptidase inhibitor activity|regulation of DNA-templated transcription in response to stress|negative regulation of programmed cell death|regulation of RNA metabolic process|purine nucleoside binding|cell morphogenesis involved in differentiation|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|ribonucleoside binding|nuclear lumen|stress-activated protein kinase signaling cascade|negative regulation of hydrolase activity|response to growth factor|proteolysis|nucleoplasm|immune response-regulating signaling pathway|kinase activity|kinase binding|programmed cell death|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|purine nucleotide binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|regulation of programmed cell death|positive regulation of innate immune response|regulation of innate immune response|neuron development|neuron differentiation|axon guidance|endopeptidase inhibitor activity|negative regulation of peptidase activity|positive regulation of transcription, DNA-templated|peptide biosynthetic process|magnesium ion binding|RNA biosynthetic process|ATP binding|regulation of proteolysis|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|posttranscriptional regulation of gene expression|neurotrophin signaling pathway|regulation of peptidase activity|pattern recognition receptor signaling pathway|axon development|translation|enzyme linked receptor protein signaling pathway|regulation of translation|regulation of apoptotic process|negative regulation of proteolysis|negative regulation of apoptotic process|protein kinase activity|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|stress-activated MAPK cascade|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cysteine-type endopeptidase inhibitor activity|neurotrophin TRK receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|toll-like receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|axonogenesis|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|negative regulation of endopeptidase activity|protein serine/threonine kinase activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|negative regulation of cysteine-type endopeptidase activity|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|regulation of cysteine-type endopeptidase activity|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|TRIF-dependent toll-like receptor signaling pathway K04373 p90 ribosomal S6 kinase[2.7.11.1] hsa04010|hsa04114|hsa04722|hsa04931|hsa04914|hsa04720|hsa04150 MAPK signaling pathway - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human) X:20149911-20267100 1104 1378 2054 2971 3475 3884 8.11698345774489 9.20777715035747 13.6157067493201 19.5715827305914 20.9627533598298 26.7629354781719 10.3134891191408 22.4324238561977 -1.12105302593873 1.53398272276724e-06 1.84233069392389e-05 DOWN ENSG00000280239 CTB-50L17.8 - - - - - - - 19:4448810-4450836 60 54 40 3 12 19 2.09383944732935 1.71263656254058 1.25853741071278 0.0937890965537649 0.343595522578965 0.621396248484187 1.6883378068609 0.352926955872306 2.25816206129617 1.53433781560039e-06 1.84233069392389e-05 UP ENSG00000155760 FZD7 frizzled class receptor 7 [Source:HGNC Symbol;Acc:HGNC:4045] GO:0032502|GO:0040007|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0048589|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0060341|GO:0008284|GO:0042127|GO:0016337|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:1901360|GO:0034446|GO:0007275|GO:0045596|GO:0048513|GO:0070489|GO:0005102|GO:0034641|GO:2000384|GO:0030155|GO:0031325|GO:0046483|GO:0042246|GO:0033554|GO:0098609|GO:0004888|GO:0045992|GO:0009611|GO:0032880|GO:0001775|GO:0031589|GO:0009966|GO:0048598|GO:0050673|GO:0045184|GO:0019904|GO:0010646|GO:0006139|GO:0007162|GO:0008104|GO:0046649|GO:0007154|GO:0001704|GO:0007165|GO:0051649|GO:0017147|GO:0014834|GO:0051301|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0019827|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0000165|GO:0050679|GO:1902533|GO:0032268|GO:0000902|GO:0042666|GO:0007186|GO:0010468|GO:0034645|GO:0010453|GO:0007166|GO:0033993|GO:0043412|GO:0072594|GO:0030097|GO:0030098|GO:0002064|GO:0051252|GO:0032386|GO:0051223|GO:0060795|GO:0030165|GO:0015031|GO:0007398|GO:0000904|GO:0009790|GO:0010628|GO:0001705|GO:0010812|GO:0036211|GO:0070201|GO:0007369|GO:0042060|GO:0046907|GO:0010454|GO:0031098|GO:0001708|GO:0007159|GO:0010810|GO:0051247|GO:0001664|GO:0050678|GO:0043403|GO:0034613|GO:0032270|GO:0042110|GO:0060429|GO:0006796|GO:0032526|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0017038|GO:0007399|GO:0071310|GO:0031328|GO:0051246|GO:0010470|GO:0017145|GO:0009059|GO:0030154|GO:1903827|GO:1902531|GO:0016070|GO:0004930|GO:0010557|GO:0006606|GO:0045165|GO:0045995|GO:0042813|GO:0030182|GO:0002521|GO:0016055|GO:1904589|GO:0070304|GO:0045893|GO:0033365|GO:0033157|GO:0031401|GO:0051169|GO:0030855|GO:0043408|GO:0048103|GO:0032774|GO:2001141|GO:0030217|GO:0016310|GO:0006605|GO:0070486|GO:0016482|GO:0003382|GO:0006886|GO:0043410|GO:0042659|GO:0032872|GO:0033077|GO:0010668|GO:0005109|GO:0042306|GO:0071300|GO:1900180|GO:0022008|GO:0006464|GO:0071396|GO:0051403|GO:0035411|GO:0006351|GO:0001712|GO:0006355|GO:0060054|GO:1903533|GO:0035567|GO:0006913|GO:0060231|GO:0046328|GO:0006468|GO:0048699|GO:0035412|GO:1903506|GO:0060070|GO:0042325|GO:0007254|GO:0001932|GO:0032874|GO:0001934|GO:0071593|GO:0042327|GO:0034504|GO:0046822|GO:0046330|GO:0051170|GO:0038030|GO:0038031 developmental process|growth|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|developmental growth|immune system development|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|single organismal cell-cell adhesion|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|transport|organic cyclic compound metabolic process|substrate adhesion-dependent cell spreading|multicellular organism development|negative regulation of cell differentiation|animal organ development|T cell aggregation|receptor binding|cellular nitrogen compound metabolic process|negative regulation of ectoderm development|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|tissue regeneration|cellular response to stress|cell-cell adhesion|transmembrane signaling receptor activity|negative regulation of embryonic development|response to wounding|regulation of protein localization|cell activation|cell-substrate adhesion|regulation of signal transduction|embryonic morphogenesis|epithelial cell proliferation|establishment of protein localization|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|negative regulation of cell adhesion|protein localization|lymphocyte activation|cell communication|formation of primary germ layer|signal transduction|establishment of localization in cell|Wnt-protein binding|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|cell division|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|MAPK cascade|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|negative regulation of ectodermal cell fate specification|G-protein coupled receptor signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of cell fate commitment|cell surface receptor signaling pathway|response to lipid|macromolecule modification|establishment of protein localization to organelle|hemopoiesis|lymphocyte differentiation|epithelial cell development|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|cell fate commitment involved in formation of primary germ layer|PDZ domain binding|protein transport|ectoderm development|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|ectoderm formation|negative regulation of cell-substrate adhesion|protein modification process|regulation of establishment of protein localization|gastrulation|wound healing|intracellular transport|negative regulation of cell fate commitment|stress-activated protein kinase signaling cascade|cell fate specification|leukocyte cell-cell adhesion|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|G-protein coupled receptor binding|regulation of epithelial cell proliferation|skeletal muscle tissue regeneration|cellular protein localization|positive regulation of cellular protein metabolic process|T cell activation|epithelium development|phosphate-containing compound metabolic process|response to retinoic acid|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|protein import|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|regulation of gastrulation|stem cell division|macromolecule biosynthetic process|cell differentiation|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|G-protein coupled receptor activity|positive regulation of macromolecule biosynthetic process|protein import into nucleus|cell fate commitment|regulation of embryonic development|Wnt-activated receptor activity|neuron differentiation|leukocyte differentiation|Wnt signaling pathway|regulation of protein import|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|nuclear transport|epithelial cell differentiation|regulation of MAPK cascade|somatic stem cell division|RNA biosynthetic process|regulation of RNA biosynthetic process|T cell differentiation|phosphorylation|protein targeting|leukocyte aggregation|cytosolic transport|epithelial cell morphogenesis|intracellular protein transport|positive regulation of MAPK cascade|regulation of cell fate specification|regulation of stress-activated MAPK cascade|T cell differentiation in thymus|ectodermal cell differentiation|frizzled binding|regulation of protein import into nucleus|cellular response to retinoic acid|regulation of protein localization to nucleus|neurogenesis|cellular protein modification process|cellular response to lipid|stress-activated MAPK cascade|catenin import into nucleus|transcription, DNA-templated|ectodermal cell fate commitment|regulation of transcription, DNA-templated|positive regulation of epithelial cell proliferation involved in wound healing|regulation of protein targeting|non-canonical Wnt signaling pathway|nucleocytoplasmic transport|mesenchymal to epithelial transition|regulation of JNK cascade|protein phosphorylation|generation of neurons|regulation of catenin import into nucleus|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|lymphocyte aggregation|positive regulation of phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|positive regulation of JNK cascade|nuclear import|non-canonical Wnt signaling pathway via MAPK cascade|non-canonical Wnt signaling pathway via JNK cascade K02432 frizzled 1/7[-] hsa05200|hsa05166|hsa05205|hsa04390|hsa04310|hsa04550|hsa04916|hsa05217 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human) 2:202034587-202038445 548 637 688 225 266 404 10.0450327911932 10.6118273773063 11.370345957949 3.69531250322557 4.00055314390008 6.94035396128981 10.6757353754828 4.87873986947182 1.12975498319383 1.54918446935046e-06 1.85889683070694e-05 UP ENSG00000166529 ZSCAN21 zinc finger and SCAN domain containing 21 [Source:HGNC Symbol;Acc:HGNC:13104] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0000981|GO:0006139|GO:0044249|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010628|GO:0010467|GO:0031328|GO:0009059|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|positive regulation of gene expression|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 7:100049774-100065038 245 251 208 82 89 127 3.25273107810842 3.02855541413369 2.48977122251271 0.975419962298106 0.969485481183916 1.58020784801543 2.92368590491827 1.17503776383248 1.31508120571319 1.55314817641412e-06 1.86290420484802e-05 UP ENSG00000170801 HTRA3 HtrA serine peptidase 3 [Source:HGNC Symbol;Acc:HGNC:30406] GO:0040007|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0023051|GO:0016043|GO:0040008|GO:0023057|GO:0016787|GO:0009058|GO:0005515|GO:0019222|GO:0006725|GO:0019838|GO:1901360|GO:0034641|GO:0046483|GO:0051128|GO:0090287|GO:0008233|GO:0071559|GO:0009966|GO:0010646|GO:0090288|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0044249|GO:0019538|GO:0010033|GO:0001558|GO:0031323|GO:0017171|GO:0010468|GO:0071773|GO:0034645|GO:0005520|GO:0090101|GO:0007166|GO:0030514|GO:0051252|GO:0071560|GO:0070848|GO:0006508|GO:0008236|GO:0010467|GO:0071310|GO:0030510|GO:0009059|GO:0016070|GO:0004252|GO:0032774|GO:2001141|GO:0071363|GO:0007179|GO:0030512|GO:0030509|GO:0007167|GO:0004175|GO:0017015|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0007178 growth|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|regulation of signaling|cellular component organization|regulation of growth|negative regulation of signaling|hydrolase activity|biosynthetic process|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|growth factor binding|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|regulation of cellular response to growth factor stimulus|peptidase activity|response to transforming growth factor beta|regulation of signal transduction|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|serine hydrolase activity|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|insulin-like growth factor binding|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|negative regulation of BMP signaling pathway|regulation of RNA metabolic process|cellular response to transforming growth factor beta stimulus|response to growth factor|proteolysis|serine-type peptidase activity|gene expression|cellular response to organic substance|regulation of BMP signaling pathway|macromolecule biosynthetic process|RNA metabolic process|serine-type endopeptidase activity|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|BMP signaling pathway|enzyme linked receptor protein signaling pathway|endopeptidase activity|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway - - - - 4:8269765-8307111 10 15 24 54 69 57 0.181461167132286 0.247393523818346 0.392664571464183 0.877998410555409 1.02735224803805 0.969415367825229 0.273839754138272 0.958255342139563 -1.80707823370624 1.55445003368609e-06 1.8637169199062e-05 DOWN ENSG00000205758 CRYZL1 crystallin zeta like 1 [Source:HGNC Symbol;Acc:HGNC:2420] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0071704|GO:0043167|GO:0044237|GO:0048037|GO:0005622|GO:0044281|GO:0043169|GO:0005737|GO:0051186|GO:0016651|GO:0042180|GO:0050662|GO:0000166|GO:0055114|GO:0005829|GO:0046872|GO:0050661|GO:0016655|GO:1901661|GO:0046914|GO:0003960|GO:0008270 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|organic substance metabolic process|ion binding|cellular metabolic process|cofactor binding|intracellular|small molecule metabolic process|cation binding|cytoplasm|cofactor metabolic process|oxidoreductase activity, acting on NAD(P)H|cellular ketone metabolic process|coenzyme binding|nucleotide binding|oxidation-reduction process|cytosol|metal ion binding|NADP binding|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|quinone metabolic process|transition metal ion binding|NADPH:quinone reductase activity|zinc ion binding - - - - 21:33589341-33643926 77 101 101 215 257 245 0.38919015793711 0.463954836344686 0.460265550609769 0.973662195346847 1.06579478524094 1.16056110062898 0.437803514963855 1.06667269373892 -1.28476211359664 1.57699435142866e-06 1.88771408851448e-05 DOWN ENSG00000011523 CEP68 centrosomal protein 68kDa [Source:HGNC Symbol;Acc:HGNC:29076] GO:0005623|GO:0009987|GO:0030054|GO:0005488|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0019899|GO:0005737|GO:0019904|GO:0008104|GO:0007017|GO:0006996|GO:0031023|GO:0005813|GO:0007010|GO:0005815|GO:0034613|GO:0019900|GO:0000226|GO:0005856|GO:0005634|GO:0033365|GO:0015630|GO:0051297|GO:0019901|GO:0010457 cell|cellular process|cell junction|binding|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|protein domain specific binding|protein localization|microtubule-based process|organelle organization|microtubule organizing center organization|centrosome|cytoskeleton organization|microtubule organizing center|cellular protein localization|kinase binding|microtubule cytoskeleton organization|cytoskeleton|nucleus|protein localization to organelle|microtubule cytoskeleton|centrosome organization|protein kinase binding|centriole-centriole cohesion - - - - 2:65056366-65087004 622 684 1271 371 400 465 3.21155695205653 3.20967704170798 5.91677383318833 1.71631349193322 1.69454701910398 2.25012773882562 4.11266927565095 1.88699608328761 1.12398363232542 1.58175840965727e-06 1.89265793835303e-05 UP ENSG00000137434 C6orf52 chromosome 6 open reading frame 52 [Source:HGNC Symbol;Acc:HGNC:20881] - - - - - - 6:10671418-10694797 12 9 10 40 43 44 0.545896473522108 0.372100413742441 0.410148244351855 1.63033439618093 1.60489677202407 1.8758362574737 0.442715043872135 1.7036891418929 -1.94421181939912 1.58710578244571e-06 1.89829551398775e-05 DOWN ENSG00000139211 AMIGO2 adhesion molecule with Ig-like domain 2 [Source:HGNC Symbol;Acc:HGNC:24073] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0044089|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0051130|GO:0010941|GO:0007275|GO:0051128|GO:0022607|GO:0098609|GO:0050803|GO:0043231|GO:0051963|GO:0060548|GO:0051965|GO:0050808|GO:0008219|GO:0016021|GO:0098742|GO:0007416|GO:0050807|GO:0043069|GO:0012501|GO:0007399|GO:0005634|GO:0043067|GO:0051960|GO:0007157|GO:0007156|GO:0042981|GO:0043066|GO:0006915 developmental process|cell|membrane|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|positive regulation of cellular component organization|regulation of cell death|multicellular organism development|regulation of cellular component organization|cellular component assembly|cell-cell adhesion|regulation of synapse structure or activity|intracellular membrane-bounded organelle|regulation of synapse assembly|negative regulation of cell death|positive regulation of synapse assembly|synapse organization|cell death|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|synapse assembly|regulation of synapse organization|negative regulation of programmed cell death|programmed cell death|nervous system development|nucleus|regulation of programmed cell death|regulation of nervous system development|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|homophilic cell adhesion via plasma membrane adhesion molecules|regulation of apoptotic process|negative regulation of apoptotic process|apoptotic process - - - - 12:47075707-47079951 1031 1176 951 2347 2577 2136 7.53639721385 7.81254406775004 6.26757867754074 15.3714816356924 15.4556540938526 14.6330600752203 7.20550665304693 15.1533986015884 -1.07246961563002 1.60176848363708e-06 1.9150659315379e-05 DOWN ENSG00000175764 TTLL11 tubulin tyrosine ligase like11 [Source:HGNC Symbol;Acc:HGNC:18113] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0016874|GO:0005622|GO:0005929|GO:0043168|GO:0005874|GO:0001882|GO:0005737|GO:0000166|GO:0007017|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0051013|GO:0044267|GO:0017076|GO:0005856|GO:0005524|GO:0030554|GO:0015630|GO:0006464|GO:0018193|GO:0018095 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|ligase activity|intracellular|cilium|anion binding|microtubule|nucleoside binding|cytoplasm|nucleotide binding|microtubule-based process|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|microtubule severing|cellular protein metabolic process|purine nucleotide binding|cytoskeleton|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|cellular protein modification process|peptidyl-amino acid modification|protein polyglutamylation - - - - 9:121821928-122093606 6 7 10 32 51 28 0.0548180544677074 0.0581298810657913 0.0823792973349438 0.261963725808146 0.382323164185668 0.239758773033753 0.0651090776228142 0.294681887675856 -2.17822778377338 1.60683448267874e-06 1.91846195495998e-05 DOWN ENSG00000280435 RP4-555D20.1 - - - - - - - 3:44115818-44117487 46 69 85 189 238 153 1.94842899252299 2.6562001605471 3.24608835259659 7.17279303851106 8.27129441085973 6.07364571514856 2.61690583522223 7.17257772150645 -1.45462968354922 1.60704475818765e-06 1.91846195495998e-05 DOWN ENSG00000146263 MMS22L MMS22 like, DNA repair protein [Source:HGNC Symbol;Acc:HGNC:21475] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0008023|GO:0006281|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0006139|GO:0031297|GO:0042555|GO:0044249|GO:0034645|GO:0035101|GO:0000725|GO:0006302|GO:0005657|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0009059|GO:0005634|GO:0006974|GO:0000724|GO:0006260|GO:0043596|GO:0006310|GO:0006261 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transcription elongation factor complex|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|replication fork processing|MCM complex|cellular biosynthetic process|cellular macromolecule biosynthetic process|FACT complex|recombinational repair|double-strand break repair|replication fork|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|DNA replication|nuclear replication fork|DNA recombination|DNA-dependent DNA replication - - - - 6:97142161-97283217 234 313 348 653 840 574 0.613530852190867 0.745837724726884 0.822645811915663 1.53401972685067 1.80703774204167 1.41046046872892 0.727338129611138 1.58383931254042 -1.12272786056926 1.62602405433286e-06 1.93940559800453e-05 DOWN ENSG00000170456 DENND5B DENN/MADD domain containing 5B [Source:HGNC Symbol;Acc:HGNC:28338] GO:0005215|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0022857|GO:0051606|GO:0009628|GO:0009605|GO:0009893|GO:0031224|GO:0005515|GO:0005085|GO:0019222|GO:0006810|GO:0009612|GO:0009582|GO:0005088|GO:0022891|GO:0043085|GO:0055085|GO:0050790|GO:0016021|GO:0051345|GO:0017112|GO:0015267|GO:0006811|GO:0015075|GO:0050982|GO:0034220|GO:0098655|GO:0005216|GO:0006812|GO:0043087|GO:0043547|GO:0008324|GO:0022890|GO:0030001|GO:0005261|GO:0005262|GO:0070588|GO:0046873|GO:0006816|GO:0015085 transporter activity|membrane|cellular process|metabolic process|response to stimulus|binding|transmembrane transporter activity|detection of stimulus|response to abiotic stimulus|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|transport|response to mechanical stimulus|detection of abiotic stimulus|Ras guanyl-nucleotide exchange factor activity|substrate-specific transmembrane transporter activity|positive regulation of catalytic activity|transmembrane transport|regulation of catalytic activity|integral component of membrane|positive regulation of hydrolase activity|Rab guanyl-nucleotide exchange factor activity|channel activity|ion transport|ion transmembrane transporter activity|detection of mechanical stimulus|ion transmembrane transport|cation transmembrane transport|ion channel activity|cation transport|regulation of GTPase activity|positive regulation of GTPase activity|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|calcium channel activity|calcium ion transmembrane transport|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity - - - - 12:31382223-31591097 131 165 258 445 501 436 0.660526583675063 0.756107724549457 1.17288024271364 2.01037491595743 2.07264400943695 2.06031658271834 0.863171516979387 2.04777850270424 -1.24634051060907 1.63807005730862e-06 1.9529929509142e-05 DOWN ENSG00000135272 MDFIC MyoD family inhibitor domain containing [Source:HGNC Symbol;Acc:HGNC:28870] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:1903828|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0016032|GO:0060341|GO:1900181|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0048524|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0030332|GO:0032880|GO:0009966|GO:0045184|GO:0009890|GO:0032387|GO:0010646|GO:0006139|GO:0043085|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0008134|GO:0090317|GO:0050790|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0050792|GO:0051224|GO:0031324|GO:0031323|GO:0005794|GO:0000165|GO:1902533|GO:0005730|GO:0032268|GO:0030111|GO:0010468|GO:0034645|GO:0042308|GO:0007166|GO:0043412|GO:0072594|GO:0010629|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0010628|GO:0051347|GO:0036211|GO:0070201|GO:0046907|GO:0019083|GO:0031981|GO:0031098|GO:0051247|GO:0005654|GO:0030957|GO:0034613|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:1903902|GO:0051174|GO:0010467|GO:0017038|GO:0019058|GO:0031328|GO:0051246|GO:0009059|GO:1903827|GO:1902531|GO:0016070|GO:0010557|GO:0005634|GO:0006606|GO:0016055|GO:1904589|GO:0070304|GO:0045893|GO:0033365|GO:0033157|GO:0031401|GO:0051169|GO:0043408|GO:0045892|GO:0046782|GO:0032774|GO:2001141|GO:0016310|GO:0006605|GO:1902679|GO:0016482|GO:0006886|GO:0043410|GO:0032872|GO:0042306|GO:1900180|GO:0050434|GO:0006464|GO:0051403|GO:0043549|GO:0006351|GO:0006355|GO:0033674|GO:1903533|GO:0006913|GO:0045859|GO:1903507|GO:0045860|GO:0043406|GO:0046328|GO:0006468|GO:1903506|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0032874|GO:0001934|GO:0042327|GO:0034504|GO:0046822|GO:0046330|GO:0051170|GO:0043507|GO:0000187|GO:0071902|GO:0071900|GO:0043506|GO:0032147|GO:0007257 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of cellular protein localization|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|endomembrane system|regulation of metabolic process|viral process|regulation of cellular localization|negative regulation of protein localization to nucleus|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|cyclin binding|regulation of protein localization|regulation of signal transduction|establishment of protein localization|negative regulation of biosynthetic process|negative regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|cell communication|signal transduction|establishment of localization in cell|transcription factor binding|negative regulation of intracellular protein transport|regulation of catalytic activity|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|regulation of viral process|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|MAPK cascade|positive regulation of intracellular signal transduction|nucleolus|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of protein import into nucleus|cell surface receptor signaling pathway|macromolecule modification|establishment of protein localization to organelle|negative regulation of gene expression|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|regulation of establishment of protein localization|intracellular transport|viral transcription|nuclear lumen|stress-activated protein kinase signaling cascade|positive regulation of protein metabolic process|nucleoplasm|Tat protein binding|cellular protein localization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|positive regulation of viral life cycle|regulation of phosphorus metabolic process|gene expression|protein import|viral life cycle|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|protein import into nucleus|Wnt signaling pathway|regulation of protein import|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|nuclear transport|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|regulation of viral transcription|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorylation|protein targeting|negative regulation of RNA biosynthetic process|cytosolic transport|intracellular protein transport|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of protein import into nucleus|regulation of protein localization to nucleus|positive regulation of viral transcription|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of kinase activity|regulation of protein targeting|nucleocytoplasmic transport|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of JNK cascade|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|positive regulation of phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|positive regulation of JNK cascade|nuclear import|positive regulation of JUN kinase activity|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|activation of protein kinase activity|activation of JUN kinase activity - - - - 7:114922154-115019916 608 688 597 1219 1588 1407 4.017936668624 4.13207442822455 3.55703748046607 7.21773753177725 8.61029449550938 8.71410216059567 3.90234952577154 8.18071139596077 -1.0678833025204 1.65707580490348e-06 1.97486391535283e-05 DOWN ENSG00000183690 EFHC2 EF-hand domain (C-terminal) containing 2 [Source:HGNC Symbol;Acc:HGNC:26233] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0005509 binding|ion binding|protein binding|cation binding|metal ion binding|calcium ion binding - - - - X:44147882-44343672 1 3 6 23 17 30 0.0199286661285874 0.0543205662897996 0.107763534773382 0.410511841974423 0.277856383973939 0.560082914202521 0.0606709223972563 0.416150380050294 -2.77802780433389 1.65867610520395e-06 1.9759823002697e-05 DOWN ENSG00000180801 ARSJ arylsulfatase family member J [Source:HGNC Symbol;Acc:HGNC:26286] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0012505|GO:0044255|GO:0016788|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0006629|GO:0005783|GO:0016021|GO:0019538|GO:0006665|GO:0046872|GO:0043412|GO:0008484|GO:0006643|GO:0036211|GO:0044267|GO:0005788|GO:0006687|GO:0004065|GO:0006664|GO:0006464|GO:0043687 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|endomembrane system|cellular lipid metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|lipid metabolic process|endoplasmic reticulum|integral component of membrane|protein metabolic process|sphingolipid metabolic process|metal ion binding|macromolecule modification|sulfuric ester hydrolase activity|membrane lipid metabolic process|protein modification process|cellular protein metabolic process|endoplasmic reticulum lumen|glycosphingolipid metabolic process|arylsulfatase activity|glycolipid metabolic process|cellular protein modification process|post-translational protein modification - - - - 4:113900284-113979727 7 3 2 27 22 37 0.0585235871778282 0.0227978171486914 0.0150757716574196 0.202251620526949 0.150912175241148 0.289901270059943 0.0321323919946464 0.21435502194268 -2.7379019304291 1.65953510284576e-06 1.97621703072826e-05 DOWN ENSG00000068024 HDAC4 histone deacetylase 4 [Source:HGNC Symbol;Acc:HGNC:14063] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0014854|GO:0097159|GO:0009892|GO:0048523|GO:0031594|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0048870|GO:0000989|GO:0040017|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0030017|GO:0030018|GO:0008284|GO:0044262|GO:0051272|GO:1903409|GO:0042127|GO:0045595|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0051130|GO:0009612|GO:1901360|GO:0010941|GO:0006082|GO:0007275|GO:0016570|GO:0003676|GO:0045596|GO:0048513|GO:0030279|GO:0034641|GO:0044281|GO:0006952|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0022607|GO:0010942|GO:0051098|GO:0061061|GO:0043231|GO:0019213|GO:0014870|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0017053|GO:0016810|GO:0005975|GO:0006928|GO:0072593|GO:0001775|GO:0031672|GO:0010592|GO:0009890|GO:0051186|GO:0003682|GO:0031674|GO:0042493|GO:0006139|GO:0055086|GO:0046649|GO:0007154|GO:0044092|GO:0051270|GO:0060491|GO:0016477|GO:0007165|GO:0030278|GO:0001503|GO:0008134|GO:0009725|GO:0008219|GO:0008285|GO:0030030|GO:0006091|GO:0048869|GO:2000145|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0003013|GO:0006996|GO:0051090|GO:0051276|GO:0032268|GO:0006109|GO:0005829|GO:0003677|GO:0071107|GO:0031344|GO:0042113|GO:0001025|GO:0010468|GO:0006936|GO:0034645|GO:0048660|GO:0003714|GO:0046872|GO:0045668|GO:0043412|GO:0030097|GO:0034097|GO:0030098|GO:0010629|GO:0019693|GO:0042692|GO:0051252|GO:0006325|GO:0070491|GO:1901216|GO:0070997|GO:0016811|GO:0045667|GO:0048659|GO:0031346|GO:0090257|GO:0010628|GO:0030334|GO:0044275|GO:0051147|GO:0048661|GO:0036211|GO:2000377|GO:0009116|GO:0060537|GO:0006954|GO:0001649|GO:1903428|GO:0051091|GO:0014894|GO:0043292|GO:0031981|GO:0030031|GO:0042826|GO:0051247|GO:0005654|GO:0043433|GO:0033558|GO:0016052|GO:1901214|GO:0055001|GO:0042641|GO:0019900|GO:0032270|GO:0012501|GO:0043467|GO:0097581|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0014896|GO:0010591|GO:0010467|GO:0000118|GO:0007399|GO:0071310|GO:0031328|GO:0019439|GO:0051246|GO:0071260|GO:0009059|GO:0030154|GO:0001501|GO:0030335|GO:0043068|GO:0007517|GO:0016070|GO:0008015|GO:0046434|GO:0033613|GO:0032870|GO:0005856|GO:0010557|GO:0016575|GO:0005634|GO:0051148|GO:0043067|GO:1903426|GO:0002076|GO:0014898|GO:0006757|GO:0016202|GO:0043393|GO:2000379|GO:0006941|GO:0006110|GO:0008016|GO:0055002|GO:0002521|GO:0015629|GO:0060538|GO:0000975|GO:0051153|GO:0045893|GO:0030032|GO:0030016|GO:0031401|GO:1902745|GO:0070555|GO:0051154|GO:0043065|GO:0048641|GO:0006937|GO:0009259|GO:0030183|GO:0045892|GO:0043523|GO:0009117|GO:0048742|GO:0032774|GO:0043565|GO:0060047|GO:0071374|GO:0014909|GO:0045980|GO:2001141|GO:0043525|GO:0016310|GO:0014910|GO:1902679|GO:0040029|GO:0014911|GO:0009132|GO:0006163|GO:0051146|GO:0042981|GO:0045820|GO:0071345|GO:0046914|GO:0019752|GO:0016568|GO:0070933|GO:0051402|GO:0034612|GO:0009166|GO:0034979|GO:0006096|GO:0070932|GO:0019901|GO:0014706|GO:0006464|GO:0019932|GO:0004407|GO:0042278|GO:0006351|GO:0006915|GO:0006355|GO:0003300|GO:0045944|GO:0006366|GO:1903507|GO:0046939|GO:1903578|GO:0006357|GO:0007519|GO:0010832|GO:0071356|GO:1903506|GO:0044212|GO:0006942|GO:0060048|GO:0017136|GO:0042325|GO:0018193|GO:1903579|GO:0042326|GO:0048747|GO:0014902|GO:0055117|GO:0032787|GO:0010830|GO:0019722|GO:0014904|GO:0030955|GO:0006338|GO:0000122|GO:0008270|GO:0006165|GO:0032446|GO:0033235|GO:0046034|GO:0010882|GO:0001047|GO:0048741|GO:0046031|GO:0006476|GO:0032041|GO:0033233|GO:0006090|GO:0018205|GO:0016925|GO:0034983 locomotion|developmental process|macromolecular complex|immune system process|synapse|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|response to inactivity|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|neuromuscular junction|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cell motility|transcription factor activity, transcription factor binding|positive regulation of locomotion|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|sarcomere|Z disc|positive regulation of cell proliferation|cellular carbohydrate metabolic process|positive regulation of cellular component movement|reactive oxygen species biosynthetic process|regulation of cell proliferation|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|positive regulation of cellular component organization|response to mechanical stimulus|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|multicellular organism development|histone modification|nucleic acid binding|negative regulation of cell differentiation|animal organ development|negative regulation of ossification|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|positive regulation of cell death|regulation of binding|muscle structure development|intracellular membrane-bounded organelle|deacetylase activity|response to muscle inactivity|cation binding|enzyme binding|cytoplasm|muscle system process|transcriptional repressor complex|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|carbohydrate metabolic process|movement of cell or subcellular component|reactive oxygen species metabolic process|cell activation|A band|positive regulation of lamellipodium assembly|negative regulation of biosynthetic process|cofactor metabolic process|chromatin binding|I band|response to drug|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|lymphocyte activation|cell communication|negative regulation of molecular function|regulation of cellular component movement|regulation of cell projection assembly|cell migration|signal transduction|regulation of ossification|ossification|transcription factor binding|response to hormone|cell death|negative regulation of cell proliferation|cell projection organization|generation of precursor metabolites and energy|cellular developmental process|regulation of cell motility|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|chromosome organization|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|cytosol|DNA binding|response to parathyroid hormone|regulation of cell projection organization|B cell activation|RNA polymerase III transcription factor binding|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|transcription corepressor activity|metal ion binding|negative regulation of osteoblast differentiation|macromolecule modification|hemopoiesis|response to cytokine|lymphocyte differentiation|negative regulation of gene expression|ribose phosphate metabolic process|muscle cell differentiation|regulation of RNA metabolic process|chromatin organization|repressing transcription factor binding|positive regulation of neuron death|neuron death|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|regulation of osteoblast differentiation|smooth muscle cell proliferation|positive regulation of cell projection organization|regulation of muscle system process|positive regulation of gene expression|regulation of cell migration|cellular carbohydrate catabolic process|regulation of muscle cell differentiation|positive regulation of smooth muscle cell proliferation|protein modification process|regulation of reactive oxygen species metabolic process|nucleoside metabolic process|muscle tissue development|inflammatory response|osteoblast differentiation|positive regulation of reactive oxygen species biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|response to denervation involved in regulation of muscle adaptation|contractile fiber|nuclear lumen|cell projection assembly|histone deacetylase binding|positive regulation of protein metabolic process|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|protein deacetylase activity|carbohydrate catabolic process|regulation of neuron death|muscle cell development|actomyosin|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|regulation of generation of precursor metabolites and energy|lamellipodium organization|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|muscle hypertrophy|regulation of lamellipodium assembly|gene expression|histone deacetylase complex|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|aromatic compound catabolic process|regulation of protein metabolic process|cellular response to mechanical stimulus|macromolecule biosynthetic process|cell differentiation|skeletal system development|positive regulation of cell migration|positive regulation of programmed cell death|muscle organ development|RNA metabolic process|blood circulation|organophosphate catabolic process|activating transcription factor binding|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|histone deacetylation|nucleus|negative regulation of muscle cell differentiation|regulation of programmed cell death|regulation of reactive oxygen species biosynthetic process|osteoblast development|cardiac muscle hypertrophy in response to stress|ATP generation from ADP|regulation of striated muscle tissue development|regulation of protein binding|positive regulation of reactive oxygen species metabolic process|striated muscle contraction|regulation of glycolytic process|regulation of heart contraction|striated muscle cell development|leukocyte differentiation|actin cytoskeleton|skeletal muscle organ development|regulatory region DNA binding|regulation of striated muscle cell differentiation|positive regulation of transcription, DNA-templated|lamellipodium assembly|myofibril|positive regulation of protein modification process|positive regulation of lamellipodium organization|response to interleukin-1|negative regulation of striated muscle cell differentiation|positive regulation of apoptotic process|regulation of skeletal muscle tissue development|regulation of muscle contraction|ribonucleotide metabolic process|B cell differentiation|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|nucleotide metabolic process|regulation of skeletal muscle fiber development|RNA biosynthetic process|sequence-specific DNA binding|heart contraction|cellular response to parathyroid hormone stimulus|smooth muscle cell migration|negative regulation of nucleotide metabolic process|regulation of RNA biosynthetic process|positive regulation of neuron apoptotic process|phosphorylation|regulation of smooth muscle cell migration|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|positive regulation of smooth muscle cell migration|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|striated muscle cell differentiation|regulation of apoptotic process|negative regulation of glycolytic process|cellular response to cytokine stimulus|transition metal ion binding|carboxylic acid metabolic process|chromatin modification|histone H4 deacetylation|neuron apoptotic process|response to tumor necrosis factor|nucleotide catabolic process|NAD-dependent protein deacetylase activity|glycolytic process|histone H3 deacetylation|protein kinase binding|striated muscle tissue development|cellular protein modification process|second-messenger-mediated signaling|histone deacetylase activity|purine nucleoside metabolic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cardiac muscle hypertrophy|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|nucleotide phosphorylation|regulation of ATP metabolic process|regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development|negative regulation of myotube differentiation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of striated muscle contraction|cardiac muscle contraction|NAD-dependent histone deacetylase activity|regulation of phosphorylation|peptidyl-amino acid modification|negative regulation of ATP metabolic process|negative regulation of phosphorylation|muscle fiber development|myotube differentiation|regulation of cardiac muscle contraction|monocarboxylic acid metabolic process|regulation of myotube differentiation|calcium-mediated signaling|myotube cell development|potassium ion binding|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|nucleoside diphosphate phosphorylation|protein modification by small protein conjugation|positive regulation of protein sumoylation|ATP metabolic process|regulation of cardiac muscle contraction by calcium ion signaling|core promoter binding|skeletal muscle fiber development|ADP metabolic process|protein deacetylation|NAD-dependent histone deacetylase activity (H3-K14 specific)|regulation of protein sumoylation|pyruvate metabolic process|peptidyl-lysine modification|protein sumoylation|peptidyl-lysine deacetylation K11406 histone deacetylase 4/5[3.5.1.98] hsa05206|hsa05203|hsa05169|hsa05034 MicroRNAs in cancer - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Alcoholism - Homo sapiens (human) 2:239048168-239401654 90 81 222 374 438 427 0.311172868132873 0.254523774038931 0.692034168490541 1.15859374634203 1.24251961224879 1.38362281215141 0.419243603554115 1.26157872358074 -1.58936955680262 1.6689637105353e-06 1.98665241683895e-05 DOWN ENSG00000136158 SPRY2 sprouty RTK signaling antagonist 2 [Source:HGNC Symbol;Acc:HGNC:11270] GO:0032502|GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0031252|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0042127|GO:0007049|GO:0004857|GO:0045595|GO:0035239|GO:0051640|GO:0009888|GO:0022402|GO:0035295|GO:0048839|GO:0010941|GO:0007275|GO:0030324|GO:0048513|GO:0050877|GO:0008047|GO:0005874|GO:0031325|GO:0051128|GO:0090287|GO:0035265|GO:0043231|GO:0019899|GO:0005737|GO:0001763|GO:0007423|GO:0001726|GO:0009887|GO:0051656|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0030323|GO:0060548|GO:0010646|GO:0090288|GO:0043085|GO:0007163|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0051649|GO:0008219|GO:0031256|GO:0008285|GO:0050790|GO:0030030|GO:0031253|GO:0019207|GO:0043086|GO:0048869|GO:0009967|GO:0007017|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0071774|GO:0060560|GO:0000165|GO:0060425|GO:1902533|GO:0032268|GO:0005829|GO:0051653|GO:0040036|GO:0031344|GO:0019210|GO:0010468|GO:0007166|GO:0002009|GO:1903047|GO:0043412|GO:0007010|GO:0043583|GO:0019887|GO:0043069|GO:0060541|GO:0048754|GO:0060437|GO:0061138|GO:0009790|GO:0010628|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0031345|GO:0042472|GO:0007600|GO:0051386|GO:1901184|GO:0030010|GO:0044344|GO:0051247|GO:0051346|GO:0070848|GO:1901185|GO:0032587|GO:0051293|GO:0019900|GO:0032270|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0048562|GO:0003401|GO:0019209|GO:0060562|GO:0071310|GO:1902532|GO:0051246|GO:0040037|GO:0030154|GO:1902531|GO:0000226|GO:0005856|GO:0005634|GO:0043067|GO:0045165|GO:0051387|GO:0060602|GO:0051896|GO:0043491|GO:0031401|GO:0008543|GO:0050954|GO:0043408|GO:0042058|GO:0051294|GO:0071363|GO:0043087|GO:0016310|GO:0051897|GO:0038179|GO:0070371|GO:0042471|GO:0007167|GO:0015630|GO:0042059|GO:0030295|GO:0043410|GO:0004860|GO:0040001|GO:0000132|GO:0042981|GO:0043066|GO:0043409|GO:0033673|GO:0060441|GO:0051056|GO:0019901|GO:0007264|GO:0006464|GO:0051058|GO:0034260|GO:0043549|GO:0006915|GO:0033674|GO:0048011|GO:0030291|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0007605|GO:0006469|GO:0006468|GO:0043407|GO:0043539|GO:0043405|GO:0042325|GO:0070374|GO:0001932|GO:0018193|GO:0042326|GO:0001934|GO:0001933|GO:0070372|GO:0070373|GO:0042327|GO:0046580|GO:0060449|GO:0007169|GO:0033138|GO:0071901|GO:0071902|GO:0018105|GO:0010801|GO:0033135|GO:0071900|GO:0018107|GO:0038127|GO:0007173 developmental process|growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|cell cycle|enzyme inhibitor activity|regulation of cell differentiation|tube morphogenesis|organelle localization|tissue development|cell cycle process|tube development|inner ear development|regulation of cell death|multicellular organism development|lung development|animal organ development|neurological system process|enzyme activator activity|microtubule|positive regulation of cellular metabolic process|regulation of cellular component organization|regulation of cellular response to growth factor stimulus|organ growth|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|morphogenesis of a branching structure|sensory organ development|ruffle|organ morphogenesis|establishment of organelle localization|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|respiratory tube development|negative regulation of cell death|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|positive regulation of catalytic activity|establishment or maintenance of cell polarity|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|establishment of localization in cell|cell death|leading edge membrane|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|cell projection membrane|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|response to fibroblast growth factor|developmental growth involved in morphogenesis|MAPK cascade|lung morphogenesis|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|spindle localization|regulation of fibroblast growth factor receptor signaling pathway|regulation of cell projection organization|kinase inhibitor activity|regulation of gene expression|cell surface receptor signaling pathway|morphogenesis of an epithelium|mitotic cell cycle process|macromolecule modification|cytoskeleton organization|ear development|protein kinase regulator activity|negative regulation of programmed cell death|respiratory system development|branching morphogenesis of an epithelial tube|lung growth|morphogenesis of a branching epithelium|embryo development|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|negative regulation of cell projection organization|inner ear morphogenesis|sensory perception|regulation of neurotrophin TRK receptor signaling pathway|regulation of ERBB signaling pathway|establishment of cell polarity|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|negative regulation of ERBB signaling pathway|ruffle membrane|establishment of spindle localization|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|embryonic organ morphogenesis|axis elongation|kinase activator activity|epithelial tube morphogenesis|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|negative regulation of fibroblast growth factor receptor signaling pathway|cell differentiation|regulation of intracellular signal transduction|microtubule cytoskeleton organization|cytoskeleton|nucleus|regulation of programmed cell death|cell fate commitment|negative regulation of neurotrophin TRK receptor signaling pathway|branch elongation of an epithelium|regulation of protein kinase B signaling|protein kinase B signaling|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|sensory perception of mechanical stimulus|regulation of MAPK cascade|regulation of epidermal growth factor receptor signaling pathway|establishment of spindle orientation|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|positive regulation of protein kinase B signaling|neurotrophin signaling pathway|ERK1 and ERK2 cascade|ear morphogenesis|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|negative regulation of epidermal growth factor receptor signaling pathway|protein kinase activator activity|positive regulation of MAPK cascade|protein kinase inhibitor activity|establishment of mitotic spindle localization|establishment of mitotic spindle orientation|regulation of apoptotic process|negative regulation of apoptotic process|negative regulation of MAPK cascade|negative regulation of kinase activity|epithelial tube branching involved in lung morphogenesis|regulation of small GTPase mediated signal transduction|protein kinase binding|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|negative regulation of GTPase activity|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|protein serine/threonine kinase inhibitor activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|sensory perception of sound|negative regulation of protein kinase activity|protein phosphorylation|negative regulation of MAP kinase activity|protein serine/threonine kinase activator activity|regulation of MAP kinase activity|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|negative regulation of Ras protein signal transduction|bud elongation involved in lung branching|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of peptidyl-serine phosphorylation|negative regulation of protein serine/threonine kinase activity|positive regulation of protein serine/threonine kinase activity|peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|regulation of peptidyl-serine phosphorylation|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K17383 protein sprouty homolog 2[-] hsa05206 MicroRNAs in cancer - Homo sapiens (human) 13:80335976-80340951 431 444 440 234 262 180 6.44967003195694 6.03842246084675 5.93645200902535 3.1374247015661 3.21683899189145 2.52441612433842 6.14151483394301 2.95955993926532 1.05321187146635 1.67828042719366e-06 1.99694634808448e-05 UP ENSG00000005469 CROT carnitine O-octanoyltransferase [Source:HGNC Symbol;Acc:HGNC:2366] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0044255|GO:0006725|GO:0006810|GO:1901360|GO:0006082|GO:0005102|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0016746|GO:0010243|GO:0005737|GO:0051186|GO:0042493|GO:0006139|GO:0055086|GO:0006629|GO:0006091|GO:0010876|GO:0010033|GO:0055114|GO:0019693|GO:0016042|GO:0044242|GO:0006631|GO:0006577|GO:0009116|GO:0034440|GO:0006811|GO:0006869|GO:0009437|GO:0005739|GO:0016747|GO:0006796|GO:0030258|GO:0015936|GO:0006820|GO:0015711|GO:0009259|GO:0005777|GO:0009117|GO:0046395|GO:0005782|GO:0015908|GO:0051791|GO:0016415|GO:0046942|GO:0006163|GO:0019752|GO:0009062|GO:0019395|GO:0042278|GO:0008374|GO:0015718|GO:0006635|GO:0032787|GO:0033540|GO:0008458 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|cellular lipid metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|organic acid metabolic process|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|response to organonitrogen compound|cytoplasm|cofactor metabolic process|response to drug|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|lipid metabolic process|generation of precursor metabolites and energy|lipid localization|response to organic substance|oxidation-reduction process|ribose phosphate metabolic process|lipid catabolic process|cellular lipid catabolic process|fatty acid metabolic process|amino-acid betaine metabolic process|nucleoside metabolic process|lipid oxidation|ion transport|lipid transport|carnitine metabolic process|mitochondrion|transferase activity, transferring acyl groups other than amino-acyl groups|phosphate-containing compound metabolic process|lipid modification|coenzyme A metabolic process|anion transport|organic anion transport|ribonucleotide metabolic process|peroxisome|nucleotide metabolic process|carboxylic acid catabolic process|peroxisomal matrix|fatty acid transport|medium-chain fatty acid metabolic process|octanoyltransferase activity|carboxylic acid transport|purine nucleotide metabolic process|carboxylic acid metabolic process|fatty acid catabolic process|fatty acid oxidation|purine nucleoside metabolic process|O-acyltransferase activity|monocarboxylic acid transport|fatty acid beta-oxidation|monocarboxylic acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase|carnitine O-octanoyltransferase activity K05940 carnitine O-octanoyltransferase[2.3.1.137] hsa04146 Peroxisome - Homo sapiens (human) 7:87345681-87399795 265 320 324 671 685 634 2.72302276352032 2.98836964923042 3.00167850960274 6.17767423582439 5.77515472070687 6.10552750228841 2.90435697411783 6.01945215293989 -1.05141340359518 1.69944346384946e-06 2.0213221183172e-05 DOWN ENSG00000247828 TMEM161B-AS1 TMEM161B antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:43839] - - - - - - 5:88268895-88436685 44 54 64 139 142 173 0.441978030618724 0.492972779362362 0.579616846220135 1.25101533376822 1.17032560560822 1.62863451936286 0.504855885400407 1.34999181957977 -1.4190071406562 1.70419804398207e-06 2.02616998825332e-05 DOWN ENSG00000142544 CTU1 cytosolic thiouridylase subunit 1 [Source:HGNC Symbol;Acc:HGNC:29590] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016772|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0019538|GO:0005829|GO:0003723|GO:0043412|GO:0036211|GO:0005739|GO:0044267|GO:0010467|GO:0016779|GO:0016070|GO:0000049|GO:0006396|GO:0034660|GO:0009451|GO:0006464|GO:0006400|GO:0006399|GO:0008033|GO:0032446|GO:0034227|GO:0002098|GO:0032447 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|protein metabolic process|cytosol|RNA binding|macromolecule modification|protein modification process|mitochondrion|cellular protein metabolic process|gene expression|nucleotidyltransferase activity|RNA metabolic process|tRNA binding|RNA processing|ncRNA metabolic process|RNA modification|cellular protein modification process|tRNA modification|tRNA metabolic process|tRNA processing|protein modification by small protein conjugation|tRNA thio-modification|tRNA wobble uridine modification|protein urmylation K14168 cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-][-] hsa04122 Sulfur relay system - Homo sapiens (human) 19:51097606-51108370 511 572 393 228 281 195 17.3198564066647 17.6197401238828 12.0096503715131 6.92396811148153 7.81443903592818 6.19422244078307 15.6497489673535 6.97754319606426 1.16534845976853 1.7093658392498e-06 2.03150508618485e-05 UP ENSG00000051108 HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 [Source:HGNC Symbol;Acc:HGNC:13744] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0009893|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:1990037|GO:0044325|GO:0006810|GO:0010941|GO:0097413|GO:0031325|GO:0033554|GO:0051098|GO:0043231|GO:0016234|GO:1903573|GO:0005737|GO:1904294|GO:0042592|GO:0009966|GO:0045184|GO:0019725|GO:0060548|GO:0010646|GO:0008104|GO:1902495|GO:0007154|GO:0044092|GO:0007165|GO:0005783|GO:0009968|GO:0051649|GO:0008219|GO:0050790|GO:0043086|GO:0016021|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0036503|GO:0032268|GO:0045732|GO:0030968|GO:0043412|GO:0030163|GO:0006984|GO:0030970|GO:0043069|GO:2001234|GO:0048878|GO:0015031|GO:0044265|GO:0036211|GO:0032269|GO:0046907|GO:1902235|GO:0055082|GO:0006986|GO:0030433|GO:0051099|GO:0051247|GO:0051346|GO:0006508|GO:0034702|GO:1902236|GO:0034613|GO:0032270|GO:0012501|GO:0035556|GO:0044267|GO:0042176|GO:1904292|GO:1903071|GO:0071310|GO:1902532|GO:0051246|GO:0035967|GO:1902531|GO:0034976|GO:0043067|GO:0097190|GO:0043393|GO:0034620|GO:0070059|GO:0044257|GO:0010466|GO:0097193|GO:2001242|GO:0010498|GO:0032527|GO:1903364|GO:0034703|GO:0030162|GO:2001243|GO:0045862|GO:0052547|GO:0036499|GO:0006886|GO:0051603|GO:0032092|GO:0042981|GO:1903069|GO:0045861|GO:0050801|GO:0043066|GO:0006464|GO:0006915|GO:0006873|GO:1903052|GO:0043281|GO:0019941|GO:1901800|GO:0010951|GO:0034704|GO:0043154|GO:0061136|GO:0030003|GO:0043161|GO:0052548|GO:0032446|GO:0006511|GO:2000117|GO:0055065|GO:0031396|GO:0032434|GO:0032436|GO:0006875|GO:2000116|GO:0006874|GO:0055074|GO:0016567|GO:0032469 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|Lewy body core|ion channel binding|transport|regulation of cell death|Lewy body|positive regulation of cellular metabolic process|cellular response to stress|regulation of binding|intracellular membrane-bounded organelle|inclusion body|negative regulation of response to endoplasmic reticulum stress|cytoplasm|positive regulation of ERAD pathway|homeostatic process|regulation of signal transduction|establishment of protein localization|cellular homeostasis|negative regulation of cell death|regulation of cell communication|protein localization|transmembrane transporter complex|cell communication|negative regulation of molecular function|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|establishment of localization in cell|cell death|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|ERAD pathway|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|endoplasmic reticulum unfolded protein response|macromolecule modification|protein catabolic process|ER-nucleus signaling pathway|retrograde protein transport, ER to cytosol|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|chemical homeostasis|protein transport|cellular macromolecule catabolic process|protein modification process|negative regulation of cellular protein metabolic process|intracellular transport|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|cellular chemical homeostasis|response to unfolded protein|ER-associated ubiquitin-dependent protein catabolic process|positive regulation of binding|positive regulation of protein metabolic process|negative regulation of hydrolase activity|proteolysis|ion channel complex|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|intracellular signal transduction|cellular protein metabolic process|regulation of protein catabolic process|regulation of ERAD pathway|positive regulation of ER-associated ubiquitin-dependent protein catabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cellular response to topologically incorrect protein|regulation of intracellular signal transduction|response to endoplasmic reticulum stress|regulation of programmed cell death|apoptotic signaling pathway|regulation of protein binding|cellular response to unfolded protein|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|cellular protein catabolic process|negative regulation of peptidase activity|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|proteasomal protein catabolic process|protein exit from endoplasmic reticulum|positive regulation of cellular protein catabolic process|cation channel complex|regulation of proteolysis|negative regulation of intrinsic apoptotic signaling pathway|positive regulation of proteolysis|regulation of peptidase activity|PERK-mediated unfolded protein response|intracellular protein transport|proteolysis involved in cellular protein catabolic process|positive regulation of protein binding|regulation of apoptotic process|regulation of ER-associated ubiquitin-dependent protein catabolic process|negative regulation of proteolysis|ion homeostasis|negative regulation of apoptotic process|cellular protein modification process|apoptotic process|cellular ion homeostasis|positive regulation of proteolysis involved in cellular protein catabolic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|negative regulation of endopeptidase activity|calcium channel complex|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of proteasomal protein catabolic process|cellular cation homeostasis|proteasome-mediated ubiquitin-dependent protein catabolic process|regulation of endopeptidase activity|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|negative regulation of cysteine-type endopeptidase activity|metal ion homeostasis|regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|cellular metal ion homeostasis|regulation of cysteine-type endopeptidase activity|cellular calcium ion homeostasis|calcium ion homeostasis|protein ubiquitination|endoplasmic reticulum calcium ion homeostasis K14027 homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein[-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 16:56932048-56944863 216 254 317 749 492 706 1.21630142232459 1.29987061997163 1.60938878126932 3.77891161489604 2.2731082825607 3.72580712680722 1.37518694118851 3.25927567475465 -1.24492363257015 1.71339194091286e-06 2.03547962610475e-05 DOWN ENSG00000157927 RADIL Ras association and DIL domains [Source:HGNC Symbol;Acc:HGNC:22226] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0007155|GO:0005622|GO:0005515|GO:0048856|GO:0048468|GO:0034446|GO:0007275|GO:0005874|GO:0031589|GO:0007154|GO:0007165|GO:0048869|GO:0000902|GO:0000904|GO:0030154|GO:0005856|GO:0015630 developmental process|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|cell adhesion|intracellular|protein binding|anatomical structure development|cell development|substrate adhesion-dependent cell spreading|multicellular organism development|microtubule|cell-substrate adhesion|cell communication|signal transduction|cellular developmental process|cell morphogenesis|cell morphogenesis involved in differentiation|cell differentiation|cytoskeleton|microtubule cytoskeleton - - - - 7:4797055-4883719 21 21 7 1 1 2 0.16318842286442 0.14830976253085 0.0490402054048254 0.00695911166657278 0.00637847166696171 0.0145634945353659 0.120179463600032 0.00930035928963346 3.69176012635148 1.72370396721309e-06 2.04528848319474e-05 UP ENSG00000079246 XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 [Source:HGNC Symbol;Acc:HGNC:12833] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0032993|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0032205|GO:0042127|GO:0006281|GO:0045087|GO:0045595|GO:0006725|GO:0048468|GO:0008022|GO:0009314|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043168|GO:0032204|GO:0006952|GO:0001882|GO:0046483|GO:0051128|GO:0033554|GO:0016817|GO:0001817|GO:0070419|GO:0045597|GO:0043231|GO:0000723|GO:0019899|GO:0005737|GO:0001816|GO:0043564|GO:0042592|GO:0009890|GO:0001819|GO:0006139|GO:0000166|GO:0048869|GO:0044249|GO:1990391|GO:0031324|GO:0031323|GO:0006996|GO:0019043|GO:0051276|GO:0005730|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0048660|GO:0051053|GO:0032479|GO:0003723|GO:0051575|GO:0035639|GO:0030097|GO:0010629|GO:0010720|GO:0051252|GO:0090656|GO:0001883|GO:0048659|GO:0032481|GO:0006302|GO:0016818|GO:0032549|GO:0031981|GO:0050769|GO:0071478|GO:0032606|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0010212|GO:0033043|GO:1904430|GO:0010467|GO:0007399|GO:0017076|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0006974|GO:0051960|GO:0000783|GO:0044389|GO:0031625|GO:0006303|GO:0000975|GO:0048863|GO:0010332|GO:0075713|GO:0032200|GO:0000781|GO:2001251|GO:0045892|GO:0032774|GO:0005524|GO:0043565|GO:2001141|GO:0030554|GO:0033044|GO:1902679|GO:0003690|GO:0003684|GO:0006310|GO:0000784|GO:0044822|GO:0002244|GO:0071479|GO:0010165|GO:0022008|GO:0050767|GO:0071103|GO:0016462|GO:0006351|GO:0006355|GO:0060218|GO:1903507|GO:0042162|GO:0003691|GO:0048699|GO:0071480|GO:0032392|GO:1903506|GO:0044212|GO:0017111|GO:0071481|GO:0016887|GO:0032508|GO:0004386|GO:0003678|GO:0042623|GO:0008026|GO:0008094|GO:0004003 developmental process|macromolecular complex|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|protein-DNA complex|regulation of developmental process|intracellular|immune system development|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|viral process|negative regulation of telomere maintenance|regulation of cell proliferation|DNA repair|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|protein C-terminus binding|response to radiation|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|regulation of telomere maintenance|defense response|nucleoside binding|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|hydrolase activity, acting on acid anhydrides|regulation of cytokine production|nonhomologous end joining complex|positive regulation of cell differentiation|intracellular membrane-bounded organelle|telomere maintenance|enzyme binding|cytoplasm|cytokine production|Ku70:Ku80 complex|homeostatic process|negative regulation of biosynthetic process|positive regulation of cytokine production|nucleobase-containing compound metabolic process|nucleotide binding|cellular developmental process|cellular biosynthetic process|DNA repair complex|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|establishment of viral latency|chromosome organization|nucleolus|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|negative regulation of DNA metabolic process|regulation of type I interferon production|RNA binding|5'-deoxyribose-5-phosphate lyase activity|purine ribonucleoside triphosphate binding|hemopoiesis|negative regulation of gene expression|positive regulation of cell development|regulation of RNA metabolic process|t-circle formation|purine nucleoside binding|smooth muscle cell proliferation|positive regulation of type I interferon production|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|positive regulation of neurogenesis|cellular response to radiation|type I interferon production|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|response to ionizing radiation|regulation of organelle organization|negative regulation of t-circle formation|gene expression|nervous system development|purine nucleotide binding|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|regulation of nervous system development|nuclear telomere cap complex|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|double-strand break repair via nonhomologous end joining|regulatory region DNA binding|stem cell differentiation|response to gamma radiation|establishment of integrated proviral latency|telomere organization|chromosome, telomeric region|negative regulation of chromosome organization|negative regulation of transcription, DNA-templated|RNA biosynthetic process|ATP binding|sequence-specific DNA binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|regulation of chromosome organization|negative regulation of RNA biosynthetic process|double-stranded DNA binding|damaged DNA binding|DNA recombination|nuclear chromosome, telomeric region|poly(A) RNA binding|hematopoietic progenitor cell differentiation|cellular response to ionizing radiation|response to X-ray|neurogenesis|regulation of neurogenesis|DNA conformation change|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|hematopoietic stem cell differentiation|negative regulation of nucleic acid-templated transcription|telomeric DNA binding|double-stranded telomeric DNA binding|generation of neurons|cellular response to gamma radiation|DNA geometric change|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|nucleoside-triphosphatase activity|cellular response to X-ray|ATPase activity|DNA duplex unwinding|helicase activity|DNA helicase activity|ATPase activity, coupled|ATP-dependent helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity K10885 ATP-dependent DNA helicase 2 subunit 2[-] hsa03450 Non-homologous end-joining - Homo sapiens (human) 2:216107464-216206303 4353 5143 5153 11822 12699 8390 35.4009594169693 38.0121925686965 37.7833745141369 86.1420070064905 84.7351934592185 63.9465641873939 37.0655088332676 78.274588217701 -1.07846669697762 1.72782708483558e-06 2.04936630078194e-05 DOWN ENSG00000119509 INVS inversin [Source:HGNC Symbol;Acc:HGNC:17870] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0023057|GO:0005622|GO:0005515|GO:0005874|GO:0043231|GO:0005737|GO:0009966|GO:0010646|GO:0005516|GO:0007154|GO:0007165|GO:0009968|GO:0030111|GO:0030178|GO:0007166|GO:0005856|GO:0005634|GO:0005819|GO:0016055|GO:0090090|GO:0060828|GO:0015630|GO:0060070 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|intracellular|protein binding|microtubule|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|regulation of cell communication|calmodulin binding|cell communication|signal transduction|negative regulation of signal transduction|regulation of Wnt signaling pathway|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|cytoskeleton|nucleus|spindle|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of canonical Wnt signaling pathway|microtubule cytoskeleton|canonical Wnt signaling pathway K19626 inversin[-] hsa04310 Wnt signaling pathway - Homo sapiens (human) 9:100099256-100301000 78 103 105 237 277 219 0.731858728445744 0.878315763204938 0.888251570336991 1.99241029065254 2.13245756736206 1.92577419727162 0.832808687329224 2.01688068509541 -1.27606871622062 1.72963021114914e-06 2.05051804147586e-05 DOWN ENSG00000267769 CTB-50L17.9 - - - - - - - 19:4454014-4455286 22 17 13 3 2 3 3.0513816584481 2.14296972549422 1.62564961133413 0.372765683753885 0.227584968274062 0.389916149280695 2.27333366509215 0.330088933769547 2.78388277093076 1.73017181834183e-06 2.05051804147586e-05 UP ENSG00000197540 GZMM granzyme M [Source:HGNC Symbol;Acc:HGNC:4712] GO:0002376|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0019835|GO:0006950|GO:0071704|GO:0006955|GO:0016787|GO:0005515|GO:0045087|GO:0006952|GO:0008233|GO:0008219|GO:0019538|GO:0017171|GO:0006508|GO:0012501|GO:0008236|GO:0004252|GO:0004175|GO:0006915 immune system process|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cytolysis|response to stress|organic substance metabolic process|immune response|hydrolase activity|protein binding|innate immune response|defense response|peptidase activity|cell death|protein metabolic process|serine hydrolase activity|proteolysis|programmed cell death|serine-type peptidase activity|serine-type endopeptidase activity|endopeptidase activity|apoptotic process - - - - 19:544034-549924 17 12 21 2 3 3 0.811953882912394 0.520896438182872 0.904325265195216 0.0855919684089598 0.117577016478139 0.134272272878565 0.745725195430161 0.112480419255221 2.72897020895669 1.75092153117904e-06 2.07428616634203e-05 UP ENSG00000233006 AC034220.3 - - - - - - - 5:132311285-132369916 5 10 12 29 43 62 0.106761528890816 0.194045584301447 0.231010149097664 0.554788006789068 0.753279348173083 1.24063079706349 0.177272420763309 0.849566050675214 -2.26075801030673 1.7770924125157e-06 2.10312280827601e-05 DOWN ENSG00000256061 DYX1C1 dyslexia susceptibility 1 candidate 1 [Source:HGNC Symbol;Acc:HGNC:21493] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0007275|GO:0005102|GO:0022607|GO:0043231|GO:0005737|GO:0007389|GO:0006928|GO:0009966|GO:0010646|GO:0007154|GO:0016477|GO:0007165|GO:0009725|GO:0030030|GO:0048869|GO:0007017|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0032268|GO:0000902|GO:0070286|GO:0033993|GO:0007010|GO:0030163|GO:0051427|GO:0044265|GO:0035082|GO:0044782|GO:0001764|GO:0030031|GO:0007018|GO:0006508|GO:0033143|GO:0006461|GO:0070925|GO:0014070|GO:0042384|GO:0044267|GO:0042176|GO:0032990|GO:0007399|GO:0071310|GO:0051246|GO:0030154|GO:0009755|GO:0048858|GO:0000226|GO:0032870|GO:0005634|GO:0048545|GO:0030522|GO:0060271|GO:0043401|GO:0044257|GO:0036159|GO:0034622|GO:0010498|GO:0036158|GO:0030162|GO:0035257|GO:0043623|GO:0071383|GO:0071407|GO:0030518|GO:0051603|GO:0009855|GO:0001578|GO:0022008|GO:0071396|GO:0033146|GO:0003341|GO:0030520|GO:0035258|GO:0048699|GO:0007368|GO:0061136|GO:0030331 locomotion|developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|multicellular organism development|receptor binding|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|cell communication|cell migration|signal transduction|response to hormone|cell projection organization|cellular developmental process|microtubule-based process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cell morphogenesis|axonemal dynein complex assembly|response to lipid|cytoskeleton organization|protein catabolic process|hormone receptor binding|cellular macromolecule catabolic process|axoneme assembly|cilium organization|neuron migration|cell projection assembly|microtubule-based movement|proteolysis|regulation of intracellular steroid hormone receptor signaling pathway|protein complex assembly|organelle assembly|response to organic cyclic compound|cilium assembly|cellular protein metabolic process|regulation of protein catabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|regulation of protein metabolic process|cell differentiation|hormone-mediated signaling pathway|cell projection morphogenesis|microtubule cytoskeleton organization|cellular response to hormone stimulus|nucleus|response to steroid hormone|intracellular receptor signaling pathway|cilium morphogenesis|steroid hormone mediated signaling pathway|cellular protein catabolic process|inner dynein arm assembly|cellular macromolecular complex assembly|proteasomal protein catabolic process|outer dynein arm assembly|regulation of proteolysis|nuclear hormone receptor binding|cellular protein complex assembly|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|proteolysis involved in cellular protein catabolic process|determination of bilateral symmetry|microtubule bundle formation|neurogenesis|cellular response to lipid|regulation of intracellular estrogen receptor signaling pathway|cilium movement|intracellular estrogen receptor signaling pathway|steroid hormone receptor binding|generation of neurons|determination of left/right symmetry|regulation of proteasomal protein catabolic process|estrogen receptor binding - - - - 15:55410525-55508234 44 62 68 163 175 140 0.692415860204017 0.886721407987165 0.964799563752846 2.29827059504957 2.25955633505933 2.06478379035314 0.847978943981343 2.20753690682068 -1.38033721081295 1.77737617916539e-06 2.10312280827601e-05 DOWN ENSG00000226200 SGMS1-AS1 SGMS1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49683] - - - - - - 10:50624951-50641451 36 37 44 95 134 116 0.193197844475513 0.18046131565006 0.21289488957603 0.456790576125267 0.590023629319862 0.58342566560359 0.195518016567201 0.543413290349573 -1.47474829530326 1.7847287269976e-06 2.11098618921499e-05 DOWN ENSG00000091409 ITGA6 integrin subunit alpha 6 [Source:HGNC Symbol;Acc:HGNC:6142] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0005604|GO:0051716|GO:0045178|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0005578|GO:0006807|GO:0006950|GO:0071704|GO:0050900|GO:0043167|GO:0009986|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048565|GO:0050817|GO:0016337|GO:0009897|GO:0006725|GO:0009888|GO:0016323|GO:0009925|GO:0035295|GO:1901360|GO:0010941|GO:0009991|GO:0098797|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0005924|GO:0043062|GO:0030155|GO:0005912|GO:0031325|GO:0046483|GO:0022607|GO:0010942|GO:0098609|GO:0005887|GO:0043169|GO:0033627|GO:0031668|GO:0009611|GO:0043235|GO:0006928|GO:0009887|GO:0032403|GO:0031589|GO:0009966|GO:0050839|GO:0030056|GO:0060548|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0097186|GO:0007154|GO:0016477|GO:0007165|GO:0009968|GO:0045785|GO:0035878|GO:0008219|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:0044249|GO:0031323|GO:0050878|GO:0010468|GO:0034645|GO:0055123|GO:0046872|GO:0007166|GO:0051345|GO:0001655|GO:0043069|GO:2001234|GO:0007596|GO:0051252|GO:0007398|GO:0010628|GO:0007160|GO:0042060|GO:0005178|GO:0072001|GO:0034329|GO:0022407|GO:0007599|GO:0030031|GO:0043588|GO:0008305|GO:0012501|GO:0006796|GO:0042476|GO:0051174|GO:0010467|GO:0030198|GO:0031328|GO:0009059|GO:0030154|GO:0022409|GO:0060173|GO:0043068|GO:0016070|GO:0010557|GO:0043067|GO:0005925|GO:0097190|GO:2001237|GO:0045893|GO:0045444|GO:0043065|GO:0032774|GO:2001141|GO:2001236|GO:0043087|GO:0016310|GO:0007229|GO:0043547|GO:0046847|GO:0007044|GO:0042981|GO:0043066|GO:0010668|GO:0042475|GO:0097191|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0042325|GO:0031581|GO:0050873|GO:0042327 locomotion|developmental process|extracellular matrix|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|basement membrane|cellular response to stimulus|basal part of cell|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|proteinaceous extracellular matrix|nitrogen compound metabolic process|response to stress|organic substance metabolic process|leukocyte migration|ion binding|cell surface|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|digestive tract development|coagulation|single organismal cell-cell adhesion|external side of plasma membrane|cellular aromatic compound metabolic process|tissue development|basolateral plasma membrane|basal plasma membrane|tube development|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|plasma membrane protein complex|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|cell-substrate adherens junction|extracellular structure organization|regulation of cell adhesion|adherens junction|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|positive regulation of cell death|cell-cell adhesion|integral component of plasma membrane|cation binding|cell adhesion mediated by integrin|cellular response to extracellular stimulus|response to wounding|receptor complex|movement of cell or subcellular component|organ morphogenesis|protein complex binding|cell-substrate adhesion|regulation of signal transduction|cell adhesion molecule binding|hemidesmosome|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|amelogenesis|cell communication|cell migration|signal transduction|negative regulation of signal transduction|positive regulation of cell adhesion|nail development|cell death|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|cellular biosynthetic process|regulation of cellular metabolic process|regulation of body fluid levels|regulation of gene expression|cellular macromolecule biosynthetic process|digestive system development|metal ion binding|cell surface receptor signaling pathway|positive regulation of hydrolase activity|urogenital system development|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|blood coagulation|regulation of RNA metabolic process|ectoderm development|positive regulation of gene expression|cell-matrix adhesion|wound healing|integrin binding|renal system development|cell junction assembly|regulation of cell-cell adhesion|hemostasis|cell projection assembly|skin development|integrin complex|programmed cell death|phosphate-containing compound metabolic process|odontogenesis|regulation of phosphorus metabolic process|gene expression|extracellular matrix organization|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|limb development|positive regulation of programmed cell death|RNA metabolic process|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|focal adhesion|apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|positive regulation of transcription, DNA-templated|fat cell differentiation|positive regulation of apoptotic process|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of extrinsic apoptotic signaling pathway|regulation of GTPase activity|phosphorylation|integrin-mediated signaling pathway|positive regulation of GTPase activity|filopodium assembly|cell-substrate junction assembly|regulation of apoptotic process|negative regulation of apoptotic process|ectodermal cell differentiation|odontogenesis of dentin-containing tooth|extrinsic apoptotic signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|regulation of phosphorylation|hemidesmosome assembly|brown fat cell differentiation|positive regulation of phosphorylation K06485 integrin alpha 6[-] hsa05200|hsa04151|hsa04810|hsa04510|hsa04514|hsa05145|hsa05414|hsa04640|hsa05222|hsa05410|hsa04512|hsa05412 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Cell adhesion molecules (CAMs) - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 2:172427354-172506282 1763 2396 3834 5982 6798 5889 11.5750017923374 14.2966918813252 22.6952580528861 35.1894840142833 36.6199617082518 36.2359164350205 16.1889839088496 36.0151207191852 -1.15359030141442 1.79122046956231e-06 2.11782558013122e-05 DOWN ENSG00000008838 MED24 mediator complex subunit 24 [Source:HGNC Symbol;Acc:HGNC:22963] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0016570|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0016746|GO:0016592|GO:0001076|GO:0006139|GO:0007154|GO:0007165|GO:0008134|GO:0009725|GO:0019787|GO:0000151|GO:0044249|GO:0019827|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0003713|GO:0051276|GO:0042809|GO:0010468|GO:0034645|GO:0033993|GO:0043412|GO:0001104|GO:0004842|GO:0051427|GO:0051252|GO:0006325|GO:0016573|GO:0010628|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0016747|GO:0006461|GO:0046966|GO:0014070|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0009755|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0043401|GO:0045893|GO:0061630|GO:0051259|GO:0032774|GO:2001141|GO:0035257|GO:0071383|GO:0071407|GO:0030518|GO:0016407|GO:0030374|GO:0016410|GO:0016568|GO:0006464|GO:0071396|GO:0006351|GO:0006355|GO:0006366|GO:0006352|GO:0006357|GO:0051291|GO:1903506|GO:0018193|GO:0030521|GO:0008080|GO:0032446|GO:0006367|GO:0006473|GO:0018205|GO:0018394|GO:0016567|GO:0006475|GO:0018393|GO:0004402 developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|mediator complex|transcription factor activity, RNA polymerase II transcription factor binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|transcription factor binding|response to hormone|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|chromosome organization|vitamin D receptor binding|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|macromolecule modification|RNA polymerase II transcription cofactor activity|ubiquitin-protein transferase activity|hormone receptor binding|regulation of RNA metabolic process|chromatin organization|histone acetylation|positive regulation of gene expression|protein modification process|nuclear lumen|transferase complex|nucleoplasm|transferase activity, transferring acyl groups other than amino-acyl groups|protein complex assembly|thyroid hormone receptor binding|response to organic cyclic compound|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity|protein oligomerization|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|acetyltransferase activity|ligand-dependent nuclear receptor transcription coactivator activity|N-acyltransferase activity|chromatin modification|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|protein heterooligomerization|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|androgen receptor signaling pathway|N-acetyltransferase activity|protein modification by small protein conjugation|transcription initiation from RNA polymerase II promoter|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|protein ubiquitination|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity K15167 mediator of RNA polymerase II transcription subunit 24[-] hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) 17:40019097-40061215 261 337 443 755 830 716 1.11547871375339 1.30897536253424 1.70702532637483 2.89111888730307 2.91049915123524 2.86789847225124 1.37715980088749 2.88983883692985 -1.06929306292778 1.81812835133336e-06 2.14793841712332e-05 DOWN ENSG00000230562 FAM133DP family with sequence similarity 133 member D, pseudogene [Source:HGNC Symbol;Acc:HGNC:44192] - - - - - - 2:157379724-157380414 347 391 309 196 158 130 35.5220056579146 36.3767952786889 28.5194174447633 17.9771321034085 13.2706768547037 12.4720761944419 33.4727394604556 14.5732950508514 1.19965951774773 1.81903750070151e-06 2.14816240292496e-05 UP ENSG00000184305 CCSER1 coiled-coil serine rich protein 1 [Source:HGNC Symbol;Acc:HGNC:29349] - - - - - - 4:90127535-91601913 0 0 2 7 13 39 0 0 0.0102859530677709 0.0357740431531183 0.0608397089350038 0.208490980846949 0.0034286510225903 0.101701577645024 -4.89055717861273 1.83929006225785e-06 2.17122046337073e-05 DOWN ENSG00000196189 SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A [Source:HGNC Symbol;Acc:HGNC:10729] GO:0040011|GO:0032502|GO:0040007|GO:0045499|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0048523|GO:0048521|GO:0050794|GO:0045321|GO:0040012|GO:0016049|GO:0006955|GO:0050795|GO:0048870|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0040008|GO:0009605|GO:0031224|GO:0005615|GO:0050793|GO:0048589|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0048514|GO:0051272|GO:0002250|GO:0016337|GO:0002286|GO:0008360|GO:0006935|GO:0045595|GO:0009888|GO:0048468|GO:0001568|GO:0007275|GO:0010632|GO:0045596|GO:0048513|GO:0070489|GO:0032535|GO:0005102|GO:0051128|GO:2000147|GO:0098609|GO:0030308|GO:0050920|GO:0006928|GO:0001775|GO:0002263|GO:0001525|GO:0046649|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0002366|GO:0048588|GO:0048638|GO:0050922|GO:0051271|GO:0048640|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0001558|GO:0002292|GO:0060560|GO:0050768|GO:0016525|GO:0000902|GO:0031175|GO:0031344|GO:0090132|GO:0007166|GO:0001944|GO:0030097|GO:0072358|GO:0030098|GO:0010721|GO:0000904|GO:0050919|GO:0030334|GO:0001667|GO:0030517|GO:0031345|GO:0060485|GO:0045765|GO:0008361|GO:0007159|GO:0022604|GO:0002460|GO:0042110|GO:1901342|GO:0048864|GO:0030516|GO:0032990|GO:0030215|GO:0007399|GO:0097485|GO:0010594|GO:0030154|GO:0048858|GO:0030335|GO:0042093|GO:0072359|GO:1902667|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:0002521|GO:0007411|GO:0001755|GO:0048863|GO:0010975|GO:0010769|GO:0048841|GO:0014031|GO:0030217|GO:0070486|GO:0046631|GO:0061564|GO:0010631|GO:0048762|GO:0042088|GO:0045665|GO:0071526|GO:0045063|GO:0022008|GO:0048667|GO:0050767|GO:0048843|GO:0048812|GO:0010977|GO:0050771|GO:0048675|GO:0014033|GO:0014032|GO:0007409|GO:0046632|GO:0048699|GO:0035710|GO:0048846|GO:0043542|GO:0050770|GO:0071593|GO:0045664|GO:0043367 locomotion|developmental process|growth|chemorepellent activity|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of cellular process|negative regulation of behavior|regulation of cellular process|leukocyte activation|regulation of locomotion|cell growth|immune response|regulation of behavior|cell motility|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|regulation of growth|response to external stimulus|intrinsic component of membrane|extracellular space|regulation of developmental process|developmental growth|immune system development|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|positive regulation of cellular component movement|adaptive immune response|single organismal cell-cell adhesion|T cell activation involved in immune response|regulation of cell shape|chemotaxis|regulation of cell differentiation|tissue development|cell development|blood vessel development|multicellular organism development|regulation of epithelial cell migration|negative regulation of cell differentiation|animal organ development|T cell aggregation|regulation of cellular component size|receptor binding|regulation of cellular component organization|positive regulation of cell motility|cell-cell adhesion|negative regulation of cell growth|regulation of chemotaxis|movement of cell or subcellular component|cell activation|cell activation involved in immune response|angiogenesis|lymphocyte activation|cell communication|regulation of cellular component movement|cell migration|signal transduction|leukocyte activation involved in immune response|developmental cell growth|regulation of developmental growth|negative regulation of chemotaxis|negative regulation of cellular component movement|negative regulation of developmental growth|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|regulation of cell growth|T cell differentiation involved in immune response|developmental growth involved in morphogenesis|negative regulation of neurogenesis|negative regulation of angiogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|epithelium migration|cell surface receptor signaling pathway|vasculature development|hemopoiesis|cardiovascular system development|lymphocyte differentiation|negative regulation of cell development|cell morphogenesis involved in differentiation|negative chemotaxis|regulation of cell migration|ameboidal-type cell migration|negative regulation of axon extension|negative regulation of cell projection organization|mesenchyme development|regulation of angiogenesis|regulation of cell size|leukocyte cell-cell adhesion|regulation of cell morphogenesis|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|T cell activation|regulation of vasculature development|stem cell development|regulation of axon extension|cell part morphogenesis|semaphorin receptor binding|nervous system development|neuron projection guidance|regulation of endothelial cell migration|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|T-helper cell differentiation|circulatory system development|regulation of axon guidance|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|leukocyte differentiation|axon guidance|neural crest cell migration|stem cell differentiation|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|regulation of axon extension involved in axon guidance|mesenchymal cell development|T cell differentiation|leukocyte aggregation|alpha-beta T cell activation|axon development|epithelial cell migration|mesenchymal cell differentiation|T-helper 1 type immune response|negative regulation of neuron differentiation|semaphorin-plexin signaling pathway|T-helper 1 cell differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|negative regulation of axon extension involved in axon guidance|neuron projection morphogenesis|negative regulation of neuron projection development|negative regulation of axonogenesis|axon extension|neural crest cell differentiation|neural crest cell development|axonogenesis|alpha-beta T cell differentiation|generation of neurons|CD4-positive, alpha-beta T cell activation|axon extension involved in axon guidance|endothelial cell migration|regulation of axonogenesis|lymphocyte aggregation|regulation of neuron differentiation|CD4-positive, alpha-beta T cell differentiation K06521 semaphorin 4[-] hsa04360 Axon guidance - Homo sapiens (human) 1:156147366-156177752 119 134 183 361 382 318 0.654154369447512 0.669451233959847 0.906985013040624 1.77802971039919 1.72292220350083 1.63829240492925 0.743530205482661 1.71308143960976 -1.20413048130832 1.84100352417774e-06 2.17238415852974e-05 DOWN ENSG00000111843 TMEM14C transmembrane protein 14C [Source:HGNC Symbol;Acc:HGNC:20952] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0031090|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0042168|GO:0005737|GO:0031966|GO:0051186|GO:0016021|GO:0044249|GO:0005740|GO:0006778|GO:0006783|GO:0005739|GO:0006779|GO:0033014 cell|membrane|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|heme metabolic process|cytoplasm|mitochondrial membrane|cofactor metabolic process|integral component of membrane|cellular biosynthetic process|mitochondrial envelope|porphyrin-containing compound metabolic process|heme biosynthetic process|mitochondrion|porphyrin-containing compound biosynthetic process|tetrapyrrole biosynthetic process - - - - 6:10722915-10731129 771 964 1133 2055 2312 1766 20.7054396657433 23.5281017667193 27.4330412240679 49.4469476118148 50.9431416819045 44.4477197498609 23.8888608855102 48.2792696811934 -1.01506579057913 1.85065732046258e-06 2.18205069688348e-05 DOWN ENSG00000231686 RP1-203P18.1 - - - - - - - X:146619597-146620584 7 4 2 29 30 23 0.501182258210126 0.260272478052913 0.1291053684144 1.86033670697589 1.76228871456927 1.54330333394607 0.296853368225813 1.72197625183041 -2.53624285858397 1.87109259476233e-06 2.20527431204242e-05 DOWN ENSG00000133657 ATP13A3 ATPase type 13A3 [Source:HGNC Symbol;Acc:HGNC:24113] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0043167|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005886|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0005887|GO:0043231|GO:0043169|GO:0042592|GO:0019725|GO:0022891|GO:0031226|GO:0055085|GO:0000166|GO:0016021|GO:0016820|GO:0046872|GO:0035639|GO:0048878|GO:0001883|GO:0016818|GO:0006811|GO:0032549|GO:0055082|GO:0015075|GO:0017076|GO:0034220|GO:0098655|GO:0005524|GO:0006812|GO:0030554|GO:0042625|GO:0050801|GO:0042626|GO:0016462|GO:0006873|GO:0008324|GO:0019829|GO:0017111|GO:0030003|GO:0016887|GO:0055065|GO:0006875|GO:0042623|GO:0006874|GO:0055074|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|ion binding|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|plasma membrane|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|nucleotide binding|integral component of membrane|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|metal ion binding|purine ribonucleoside triphosphate binding|chemical homeostasis|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|ribonucleoside binding|cellular chemical homeostasis|ion transmembrane transporter activity|purine nucleotide binding|ion transmembrane transport|cation transmembrane transport|ATP binding|cation transport|adenyl nucleotide binding|ATPase coupled ion transmembrane transporter activity|ion homeostasis|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|cellular ion homeostasis|cation transmembrane transporter activity|cation-transporting ATPase activity|nucleoside-triphosphatase activity|cellular cation homeostasis|ATPase activity|metal ion homeostasis|cellular metal ion homeostasis|ATPase activity, coupled|cellular calcium ion homeostasis|calcium ion homeostasis|ATPase activity, coupled to movement of substances - - - - 3:194402672-194498364 1856 2289 3751 4756 7322 7441 5.47990603719396 6.14215908805389 9.98519208901402 12.5815679238919 17.7375182934321 20.5899551324173 7.20241907142062 16.9696804499138 -1.23640594822631 1.87880924189797e-06 2.21349530811453e-05 DOWN ENSG00000137275 RIPK1 receptor interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:HGNC:10019] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0042802|GO:0002757|GO:1903706|GO:0045087|GO:0045595|GO:0006725|GO:0006810|GO:1901360|GO:0010941|GO:0098797|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0043168|GO:0043062|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0010942|GO:0001817|GO:0045597|GO:0043231|GO:0019899|GO:0005737|GO:0002218|GO:0001816|GO:0043235|GO:0032403|GO:0072593|GO:0009966|GO:1990000|GO:0001819|GO:0019904|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0007154|GO:0044092|GO:0055085|GO:0007165|GO:0050778|GO:0009968|GO:0008219|GO:0050790|GO:0000166|GO:0043086|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0051090|GO:0000165|GO:1902533|GO:2001235|GO:0032268|GO:0005829|GO:0010468|GO:0005126|GO:0034645|GO:0032479|GO:0007166|GO:0001959|GO:0035639|GO:0043412|GO:0030097|GO:0002758|GO:0034097|GO:0030163|GO:0051345|GO:0043069|GO:2001234|GO:0051252|GO:0001883|GO:0051604|GO:0044265|GO:0032481|GO:0010628|GO:0051347|GO:0036211|GO:0032269|GO:2000377|GO:0070513|GO:0006811|GO:0032549|GO:0032757|GO:0051091|GO:0010939|GO:0031098|GO:0010940|GO:0032606|GO:0051247|GO:0051346|GO:0070848|GO:0006508|GO:0034765|GO:0005739|GO:0002764|GO:0006461|GO:0016301|GO:0043269|GO:0032270|GO:0012501|GO:0006796|GO:0097342|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0045639|GO:0071310|GO:1902532|GO:0017076|GO:0030198|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0045121|GO:1901264|GO:0043068|GO:1902531|GO:0016070|GO:0016773|GO:0031264|GO:0010557|GO:0043067|GO:0045089|GO:0022898|GO:0045637|GO:0097190|GO:0045088|GO:0032637|GO:0044389|GO:0034220|GO:0097527|GO:2000379|GO:2001237|GO:0032680|GO:0031625|GO:0002521|GO:0002761|GO:0015858|GO:0044257|GO:0010466|GO:0070304|GO:0045893|GO:0006820|GO:0043124|GO:0019221|GO:0031401|GO:0043122|GO:0098656|GO:0043065|GO:0010803|GO:0051259|GO:0043408|GO:0016485|GO:0032813|GO:0097296|GO:0032774|GO:2001240|GO:0005524|GO:0030162|GO:2001141|GO:0097192|GO:0045862|GO:2001236|GO:0071363|GO:0030554|GO:0016310|GO:0051092|GO:0052547|GO:2001238|GO:0032640|GO:0002221|GO:0032412|GO:0043123|GO:0007249|GO:0097300|GO:2001269|GO:0002763|GO:0043410|GO:0097435|GO:0032872|GO:0042981|GO:0071345|GO:0044070|GO:0045861|GO:0043066|GO:0004672|GO:0060544|GO:0060545|GO:0034612|GO:0032760|GO:0097343|GO:0030099|GO:0071550|GO:0006464|GO:0010952|GO:0097191|GO:1903959|GO:0051403|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0033674|GO:0045944|GO:0006366|GO:0070926|GO:0002573|GO:0045859|GO:0010950|GO:0045860|GO:0002224|GO:0043406|GO:0046328|GO:0006357|GO:0043281|GO:0006468|GO:0051291|GO:0071356|GO:1903506|GO:0043405|GO:2001239|GO:0042325|GO:0007254|GO:0001932|GO:0018193|GO:0070266|GO:0010951|GO:0004674|GO:0033209|GO:0031638|GO:0032874|GO:0043280|GO:0001934|GO:0006919|GO:0051260|GO:0043154|GO:0045651|GO:1901026|GO:0042327|GO:0008625|GO:1902041|GO:0052548|GO:0005123|GO:0046330|GO:2000117|GO:0030225|GO:2001056|GO:0043507|GO:0000187|GO:0046777|GO:0002756|GO:0071902|GO:0018105|GO:0034138|GO:0071900|GO:0043506|GO:2000116|GO:0034142|GO:0097202|GO:0032147|GO:0007257|GO:0070231|GO:0036289|GO:0035666 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|identical protein binding|immune response-activating signal transduction|regulation of hemopoiesis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|regulation of cell death|plasma membrane protein complex|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|anion binding|extracellular structure organization|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|positive regulation of cell death|regulation of cytokine production|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|activation of innate immune response|cytokine production|receptor complex|protein complex binding|reactive oxygen species metabolic process|regulation of signal transduction|amyloid fibril formation|positive regulation of cytokine production|protein domain specific binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|cell communication|negative regulation of molecular function|transmembrane transport|signal transduction|positive regulation of immune response|negative regulation of signal transduction|cell death|regulation of catalytic activity|nucleotide binding|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|MAPK cascade|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|regulation of type I interferon production|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|hemopoiesis|innate immune response-activating signal transduction|response to cytokine|protein catabolic process|positive regulation of hydrolase activity|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|purine nucleoside binding|protein maturation|cellular macromolecule catabolic process|positive regulation of type I interferon production|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of reactive oxygen species metabolic process|death domain binding|ion transport|ribonucleoside binding|positive regulation of interleukin-8 production|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of necrotic cell death|stress-activated protein kinase signaling cascade|positive regulation of necrotic cell death|type I interferon production|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|proteolysis|regulation of ion transmembrane transport|mitochondrion|immune response-regulating signaling pathway|protein complex assembly|kinase activity|regulation of ion transport|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|ripoptosome|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|positive regulation of myeloid cell differentiation|cellular response to organic substance|negative regulation of intracellular signal transduction|purine nucleotide binding|extracellular matrix organization|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|membrane raft|carbohydrate derivative transport|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|death-inducing signaling complex|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|positive regulation of innate immune response|regulation of transmembrane transporter activity|regulation of myeloid cell differentiation|apoptotic signaling pathway|regulation of innate immune response|interleukin-8 production|ubiquitin-like protein ligase binding|ion transmembrane transport|necroptotic signaling pathway|positive regulation of reactive oxygen species metabolic process|negative regulation of extrinsic apoptotic signaling pathway|regulation of tumor necrosis factor production|ubiquitin protein ligase binding|leukocyte differentiation|regulation of myeloid leukocyte differentiation|nucleoside transport|cellular protein catabolic process|negative regulation of peptidase activity|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|anion transport|negative regulation of I-kappaB kinase/NF-kappaB signaling|cytokine-mediated signaling pathway|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|anion transmembrane transport|positive regulation of apoptotic process|regulation of tumor necrosis factor-mediated signaling pathway|protein oligomerization|regulation of MAPK cascade|protein processing|tumor necrosis factor receptor superfamily binding|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|RNA biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|ATP binding|regulation of proteolysis|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|positive regulation of proteolysis|regulation of extrinsic apoptotic signaling pathway|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|positive regulation of NF-kappaB transcription factor activity|regulation of peptidase activity|positive regulation of extrinsic apoptotic signaling pathway|tumor necrosis factor production|pattern recognition receptor signaling pathway|regulation of ion transmembrane transporter activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|programmed necrotic cell death|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|positive regulation of myeloid leukocyte differentiation|positive regulation of MAPK cascade|fibril organization|regulation of stress-activated MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|regulation of anion transport|negative regulation of proteolysis|negative regulation of apoptotic process|protein kinase activity|regulation of necroptotic process|positive regulation of necroptotic process|response to tumor necrosis factor|positive regulation of tumor necrosis factor production|ripoptosome assembly|myeloid cell differentiation|death-inducing signaling complex assembly|cellular protein modification process|positive regulation of peptidase activity|extrinsic apoptotic signaling pathway|regulation of anion transmembrane transport|stress-activated MAPK cascade|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of ATP:ADP antiporter activity|myeloid leukocyte differentiation|regulation of protein kinase activity|positive regulation of endopeptidase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|protein heterooligomerization|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|necroptotic process|negative regulation of endopeptidase activity|protein serine/threonine kinase activity|tumor necrosis factor-mediated signaling pathway|zymogen activation|positive regulation of stress-activated MAPK cascade|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|protein homooligomerization|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of macrophage differentiation|ripoptosome assembly involved in necroptotic process|positive regulation of phosphorylation|extrinsic apoptotic signaling pathway via death domain receptors|regulation of extrinsic apoptotic signaling pathway via death domain receptors|regulation of endopeptidase activity|death receptor binding|positive regulation of JNK cascade|negative regulation of cysteine-type endopeptidase activity|macrophage differentiation|positive regulation of cysteine-type endopeptidase activity|positive regulation of JUN kinase activity|activation of MAPK activity|protein autophosphorylation|MyD88-independent toll-like receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|peptidyl-serine phosphorylation|toll-like receptor 3 signaling pathway|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|regulation of cysteine-type endopeptidase activity|toll-like receptor 4 signaling pathway|activation of cysteine-type endopeptidase activity|activation of protein kinase activity|activation of JUN kinase activity|T cell apoptotic process|peptidyl-serine autophosphorylation|TRIF-dependent toll-like receptor signaling pathway K02861 receptor-interacting serine/threonine-protein kinase 1[2.7.11.1] hsa05169|hsa04210|hsa05160|hsa04668|hsa04620|hsa04064|hsa04622|hsa04623 Epstein-Barr virus infection - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|RIG-I-like receptor signaling pathway - Homo sapiens (human)|Cytosolic DNA-sensing pathway - Homo sapiens (human) 6:3063991-3115187 1396 1487 850 603 631 556 15.12693411169 14.6438986389194 8.30421913017432 5.85437189010024 5.6100011640344 5.64637385654684 12.6916839602612 5.70358230356049 1.15394326543809 1.88207699027496e-06 2.2155964695453e-05 UP ENSG00000157014 TATDN2 TatD DNase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28988] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0006725|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0019538|GO:0010033|GO:0046872|GO:0030968|GO:0044265|GO:0006986|GO:0031981|GO:0004518|GO:0005654|GO:0006259|GO:0044267|GO:0071310|GO:0019439|GO:0035967|GO:0034976|GO:0005634|GO:0034620|GO:0004536|GO:0036498|GO:0004519|GO:0006308|GO:0090305|GO:0004520|GO:0016888 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|protein metabolic process|response to organic substance|metal ion binding|endoplasmic reticulum unfolded protein response|cellular macromolecule catabolic process|response to unfolded protein|nuclear lumen|nuclease activity|nucleoplasm|DNA metabolic process|cellular protein metabolic process|cellular response to organic substance|aromatic compound catabolic process|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|nucleus|cellular response to unfolded protein|deoxyribonuclease activity|IRE1-mediated unfolded protein response|endonuclease activity|DNA catabolic process|nucleic acid phosphodiester bond hydrolysis|endodeoxyribonuclease activity|endodeoxyribonuclease activity, producing 5'-phosphomonoesters - - - - 3:10248023-10281218 1466 1251 1032 657 736 549 11.3037105222672 8.76646023271087 7.17432027506117 4.53889705920334 4.65621441404748 3.96723978647737 9.08149701001308 4.3874504199094 1.04954731108869 1.88165000977624e-06 2.2155964695453e-05 UP ENSG00000072274 TFRC transferrin receptor [Source:HGNC Symbol;Acc:HGNC:11763] GO:0040011|GO:0032502|GO:0032991|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0097159|GO:0004872|GO:0022857|GO:0043229|GO:0006950|GO:0009628|GO:0009986|GO:0043227|GO:0071944|GO:0009605|GO:0031224|GO:0005615|GO:0005905|GO:0005622|GO:0002520|GO:0072562|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0042802|GO:0016032|GO:0009897|GO:0008565|GO:0016323|GO:0006810|GO:0009991|GO:0098797|GO:0007275|GO:0003676|GO:0048513|GO:0006952|GO:0001618|GO:0031982|GO:0034105|GO:0005887|GO:0043231|GO:0051087|GO:0005737|GO:0043235|GO:0042592|GO:0046983|GO:0045184|GO:0048771|GO:0019725|GO:0022891|GO:0048871|GO:0042493|GO:0031226|GO:0008104|GO:1990712|GO:0055085|GO:0045780|GO:0070062|GO:0045124|GO:0001666|GO:0010008|GO:0031072|GO:0034103|GO:0001948|GO:0048869|GO:0016021|GO:0010035|GO:0010033|GO:0038024|GO:0005768|GO:0007568|GO:0051701|GO:0007584|GO:0016192|GO:0046850|GO:0003723|GO:0033993|GO:0030097|GO:0031410|GO:0048878|GO:0001894|GO:0004998|GO:0015031|GO:0010038|GO:0016023|GO:0030544|GO:0006811|GO:0008320|GO:0006954|GO:0055082|GO:0046849|GO:0015075|GO:0055037|GO:0048471|GO:0031988|GO:0046688|GO:0005739|GO:0032526|GO:0019058|GO:0010039|GO:0035690|GO:0030154|GO:0031667|GO:0042803|GO:0010042|GO:0055038|GO:0033572|GO:0002521|GO:0046718|GO:0006812|GO:0002526|GO:0003725|GO:0045453|GO:0050801|GO:0044822|GO:0030099|GO:0006897|GO:0030260|GO:0015450|GO:0006873|GO:0008324|GO:0002573|GO:0033570|GO:0042470|GO:0006898|GO:0022890|GO:0030001|GO:0006953|GO:0030003|GO:0055065|GO:0030316|GO:0006875|GO:0046873|GO:0015091|GO:0046915|GO:0006826|GO:0006879|GO:0055072|GO:0097286|GO:0005381 locomotion|developmental process|macromolecular complex|transporter activity|immune system process|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|receptor activity|transmembrane transporter activity|intracellular organelle|response to stress|response to abiotic stimulus|cell surface|membrane-bounded organelle|cell periphery|response to external stimulus|intrinsic component of membrane|extracellular space|coated pit|intracellular|immune system development|blood microparticle|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|identical protein binding|viral process|external side of plasma membrane|protein transporter activity|basolateral plasma membrane|transport|response to extracellular stimulus|plasma membrane protein complex|multicellular organism development|nucleic acid binding|animal organ development|defense response|virus receptor activity|vesicle|positive regulation of tissue remodeling|integral component of plasma membrane|intracellular membrane-bounded organelle|chaperone binding|cytoplasm|receptor complex|homeostatic process|protein dimerization activity|establishment of protein localization|tissue remodeling|cellular homeostasis|substrate-specific transmembrane transporter activity|multicellular organismal homeostasis|response to drug|intrinsic component of plasma membrane|protein localization|HFE-transferrin receptor complex|transmembrane transport|positive regulation of bone resorption|extracellular exosome|regulation of bone resorption|response to hypoxia|endosome membrane|heat shock protein binding|regulation of tissue remodeling|glycoprotein binding|cellular developmental process|integral component of membrane|response to inorganic substance|response to organic substance|cargo receptor activity|endosome|aging|interaction with host|response to nutrient|vesicle-mediated transport|regulation of bone remodeling|RNA binding|response to lipid|hemopoiesis|cytoplasmic vesicle|chemical homeostasis|tissue homeostasis|transferrin receptor activity|protein transport|response to metal ion|cytoplasmic, membrane-bounded vesicle|Hsp70 protein binding|ion transport|protein transmembrane transporter activity|inflammatory response|cellular chemical homeostasis|bone remodeling|ion transmembrane transporter activity|recycling endosome|perinuclear region of cytoplasm|membrane-bounded vesicle|response to copper ion|mitochondrion|response to retinoic acid|viral life cycle|response to iron ion|cellular response to drug|cell differentiation|response to nutrient levels|protein homodimerization activity|response to manganese ion|recycling endosome membrane|transferrin transport|leukocyte differentiation|viral entry into host cell|cation transport|acute inflammatory response|double-stranded RNA binding|bone resorption|ion homeostasis|poly(A) RNA binding|myeloid cell differentiation|endocytosis|entry into host cell|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|cellular ion homeostasis|cation transmembrane transporter activity|myeloid leukocyte differentiation|transferrin transmembrane transporter activity|melanosome|receptor-mediated endocytosis|inorganic cation transmembrane transporter activity|metal ion transport|acute-phase response|cellular cation homeostasis|metal ion homeostasis|osteoclast differentiation|cellular metal ion homeostasis|metal ion transmembrane transporter activity|ferric iron transmembrane transporter activity|transition metal ion transmembrane transporter activity|iron ion transport|cellular iron ion homeostasis|iron ion homeostasis|iron ion import|iron ion transmembrane transporter activity K06503 transferrin receptor[-] hsa04144|hsa04145|hsa04066|hsa04640 Endocytosis - Homo sapiens (human)|Phagosome - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human) 3:196027183-196082189 22842 26838 20331 12988 14036 8132 127.34640485325 135.982413668249 102.194033780006 64.8772659577359 64.2042648148035 42.4892321478554 121.840950767168 57.1902543067983 1.09115787895895 1.89817518920275e-06 2.23366661799208e-05 UP ENSG00000129749 CHRNA10 cholinergic receptor, nicotinic alpha 10 [Source:HGNC Symbol;Acc:HGNC:13800] GO:0032502|GO:0032991|GO:0004871|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0042995|GO:0004872|GO:0022857|GO:0051606|GO:0008283|GO:0050794|GO:0043167|GO:0009628|GO:0042165|GO:0038023|GO:0044297|GO:0009653|GO:0071944|GO:0009605|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0097060|GO:0042127|GO:0030594|GO:0043025|GO:0006810|GO:0009612|GO:0048839|GO:0098797|GO:0007275|GO:0048513|GO:0050877|GO:0005102|GO:0045211|GO:0009582|GO:0005887|GO:0043169|GO:0004888|GO:0005737|GO:0007267|GO:0007423|GO:0043235|GO:0009887|GO:0042592|GO:0043005|GO:0048598|GO:0043204|GO:0048568|GO:0019725|GO:0036477|GO:0022891|GO:0031226|GO:0050906|GO:1902495|GO:0007154|GO:0055085|GO:0042166|GO:0016021|GO:0005829|GO:0030424|GO:0043583|GO:0015464|GO:0048878|GO:0009790|GO:0015267|GO:0006811|GO:0055082|GO:0042472|GO:0015075|GO:0007600|GO:0034702|GO:0050982|GO:0050974|GO:0048562|GO:0005892|GO:0034220|GO:0050910|GO:0015276|GO:0098655|GO:0005216|GO:0050954|GO:0006812|GO:0042471|GO:0050801|GO:0006873|GO:0008324|GO:0007605|GO:0005230|GO:0022890|GO:0030001|GO:0005261|GO:0030003|GO:0007268|GO:0005262|GO:0070588|GO:0005231|GO:0007271|GO:0055065|GO:0006875|GO:0046873|GO:0004889|GO:0006874|GO:0006816|GO:0055074|GO:0015085|GO:0051480|GO:0007204 developmental process|macromolecular complex|signal transducer activity|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cell projection|receptor activity|transmembrane transporter activity|detection of stimulus|cell proliferation|regulation of cellular process|ion binding|response to abiotic stimulus|neurotransmitter binding|signaling receptor activity|cell body|anatomical structure morphogenesis|cell periphery|response to external stimulus|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|synaptic membrane|regulation of cell proliferation|neurotransmitter receptor activity|neuronal cell body|transport|response to mechanical stimulus|inner ear development|plasma membrane protein complex|multicellular organism development|animal organ development|neurological system process|receptor binding|postsynaptic membrane|detection of abiotic stimulus|integral component of plasma membrane|cation binding|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|sensory organ development|receptor complex|organ morphogenesis|homeostatic process|neuron projection|embryonic morphogenesis|perikaryon|embryonic organ development|cellular homeostasis|somatodendritic compartment|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|detection of stimulus involved in sensory perception|transmembrane transporter complex|cell communication|transmembrane transport|acetylcholine binding|integral component of membrane|cytosol|axon|ear development|acetylcholine receptor activity|chemical homeostasis|embryo development|channel activity|ion transport|cellular chemical homeostasis|inner ear morphogenesis|ion transmembrane transporter activity|sensory perception|ion channel complex|detection of mechanical stimulus|detection of mechanical stimulus involved in sensory perception|embryonic organ morphogenesis|acetylcholine-gated channel complex|ion transmembrane transport|detection of mechanical stimulus involved in sensory perception of sound|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|sensory perception of mechanical stimulus|cation transport|ear morphogenesis|ion homeostasis|cellular ion homeostasis|cation transmembrane transporter activity|sensory perception of sound|extracellular ligand-gated ion channel activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|cellular cation homeostasis|synaptic transmission|calcium channel activity|calcium ion transmembrane transport|excitatory extracellular ligand-gated ion channel activity|synaptic transmission, cholinergic|metal ion homeostasis|cellular metal ion homeostasis|metal ion transmembrane transporter activity|acetylcholine-activated cation-selective channel activity|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|calcium ion transmembrane transporter activity|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04811 nicotinic acetylcholine receptor alpha-10[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 11:3665587-3671384 102 65 46 22 22 11 1.82940028535936 1.05950939650035 0.743844737194494 0.353528052519858 0.323749471276713 0.18489191579749 1.21091813968473 0.28738981319802 2.0750205093316 1.9013893767129e-06 2.23656731490886e-05 UP ENSG00000197860 SGTB small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta [Source:HGNC Symbol;Acc:HGNC:23567] GO:0005488|GO:0005515 binding|protein binding - - - - 5:65665928-65723035 254 267 520 142 125 164 3.06869109840642 2.931637929935 5.66417067629247 1.53710682819988 1.23907171566211 1.85690897697752 3.8881665682113 1.5443625069465 1.33207859002747 1.90678647495366e-06 2.24203243100695e-05 UP ENSG00000079805 DNM2 dynamin 2 [Source:HGNC Symbol;Acc:HGNC:2974] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0030496|GO:0051716|GO:0042995|GO:0097159|GO:0030055|GO:0048523|GO:0044877|GO:0050794|GO:0060076|GO:0019882|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0044089|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0019953|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0030427|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0023057|GO:0009893|GO:0032504|GO:0031252|GO:0016787|GO:0009058|GO:0005905|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0097060|GO:0031090|GO:0048609|GO:0019222|GO:0007507|GO:1903409|GO:0007049|GO:0045595|GO:0006725|GO:0051640|GO:0048468|GO:0009314|GO:0019884|GO:0006810|GO:0022402|GO:0031623|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0034446|GO:0007275|GO:0060627|GO:0048513|GO:0032535|GO:0005102|GO:0034641|GO:0043168|GO:0005924|GO:0005874|GO:0044281|GO:0030155|GO:0005912|GO:2001057|GO:0001882|GO:0043270|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0030426|GO:0033554|GO:0016817|GO:0045211|GO:0090287|GO:0022607|GO:0010942|GO:0045807|GO:0045597|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0012506|GO:0001726|GO:0071559|GO:0032403|GO:0072593|GO:0051656|GO:0001917|GO:0043005|GO:0031589|GO:0030666|GO:0009966|GO:0030027|GO:0045184|GO:0010592|GO:0014069|GO:0001891|GO:0006979|GO:0019904|GO:0010646|GO:0090288|GO:0006139|GO:0043085|GO:0008104|GO:0007154|GO:0055085|GO:0061024|GO:0007276|GO:0060491|GO:0007165|GO:0048588|GO:0009968|GO:0070062|GO:0048638|GO:0003279|GO:0051649|GO:0045785|GO:0008092|GO:0002504|GO:0008219|GO:0031256|GO:0050790|GO:0048002|GO:0000166|GO:0071804|GO:0030030|GO:0031253|GO:0043548|GO:0048869|GO:0010035|GO:0044249|GO:0010033|GO:0001558|GO:0031323|GO:0010256|GO:0032411|GO:0005794|GO:0005768|GO:0006996|GO:0003205|GO:0060560|GO:0016192|GO:0051650|GO:0015631|GO:0000902|GO:0034465|GO:0006909|GO:0005829|GO:0031175|GO:0005813|GO:0007186|GO:0031344|GO:0010468|GO:0034645|GO:0005802|GO:0036312|GO:0048232|GO:0090101|GO:0007166|GO:0035639|GO:1903047|GO:0001944|GO:1900026|GO:0007030|GO:0072358|GO:0031410|GO:0051345|GO:0002031|GO:0008277|GO:1903526|GO:0010720|GO:0060976|GO:0051252|GO:0017124|GO:0005815|GO:0001883|GO:0050998|GO:0044770|GO:0015031|GO:0048489|GO:0031346|GO:0000904|GO:0008017|GO:0071417|GO:0010628|GO:0034767|GO:0071731|GO:0050699|GO:0007009|GO:0016023|GO:0071869|GO:0016818|GO:2000377|GO:0000278|GO:0060840|GO:0071560|GO:0046907|GO:0006811|GO:0032549|GO:0046209|GO:1903428|GO:0043279|GO:0003231|GO:0071867|GO:0030031|GO:0034599|GO:0008361|GO:0071478|GO:0045744|GO:0030100|GO:0010810|GO:0048471|GO:0070848|GO:0031988|GO:0034765|GO:0045428|GO:0001664|GO:0022604|GO:0050766|GO:0043269|GO:0043268|GO:0032587|GO:0051341|GO:0019900|GO:0012501|GO:0014070|GO:0000302|GO:0097581|GO:0010212|GO:0035556|GO:0030659|GO:0060359|GO:0071241|GO:0033043|GO:0010591|GO:0010467|GO:0010765|GO:0030516|GO:0032990|GO:1900024|GO:0007399|GO:0071310|GO:0000139|GO:0032414|GO:0017076|GO:0051648|GO:0031328|GO:0006809|GO:0071805|GO:0010770|GO:0009059|GO:0010811|GO:0030154|GO:0048858|GO:0003281|GO:0043068|GO:1902531|GO:0016070|GO:0072359|GO:0005856|GO:0010557|GO:0005634|GO:0009416|GO:0042220|GO:0043067|GO:1990138|GO:1903426|GO:0022898|GO:0051960|GO:0005925|GO:0002495|GO:0034220|GO:2000379|GO:0043112|GO:0048666|GO:0030182|GO:0033572|GO:0060271|GO:0032781|GO:0007283|GO:0032561|GO:0045893|GO:0098655|GO:0010975|GO:0030032|GO:1902745|GO:1901379|GO:0043065|GO:0071242|GO:0050764|GO:0030139|GO:0010769|GO:0071245|GO:0000086|GO:0032774|GO:0044772|GO:0006812|GO:2001141|GO:0071363|GO:0050780|GO:0048193|GO:1902170|GO:0071407|GO:0007179|GO:1903358|GO:0061564|GO:0030512|GO:0016482|GO:0071732|GO:0032412|GO:0007167|GO:0030135|GO:0019886|GO:0015630|GO:0097320|GO:1902307|GO:0042981|GO:0035904|GO:0045429|GO:2000651|GO:0005525|GO:0071479|GO:0006897|GO:0051056|GO:0010165|GO:0034614|GO:0019901|GO:0022008|GO:0048667|GO:0007264|GO:0050767|GO:0048812|GO:0019001|GO:1901381|GO:0016462|GO:0002029|GO:0071870|GO:0017015|GO:0006351|GO:0006915|GO:0006355|GO:0048675|GO:0043462|GO:1901018|GO:0030136|GO:1901016|GO:0007265|GO:0046578|GO:0043266|GO:0007409|GO:0048699|GO:1903506|GO:0017111|GO:1903408|GO:1903351|GO:0031749|GO:0006898|GO:0050999|GO:0002028|GO:1902305|GO:0030001|GO:2000649|GO:0007178|GO:0006907|GO:0006892|GO:0045334|GO:0050770|GO:0071481|GO:0045664|GO:0015672|GO:0006813|GO:0035725|GO:0006814|GO:0016601|GO:0003924|GO:0044351|GO:0035020|GO:0006893|GO:0006826 developmental process|growth|macromolecular complex|reproduction|immune system process|synapse|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|midbody|cellular response to stimulus|cell projection|organic cyclic compound binding|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|excitatory synapse|antigen processing and presentation|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|positive regulation of cellular component biogenesis|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|sexual reproduction|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|cell leading edge|hydrolase activity|biosynthetic process|coated pit|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|synaptic membrane|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|heart development|reactive oxygen species biosynthetic process|cell cycle|regulation of cell differentiation|cellular aromatic compound metabolic process|organelle localization|cell development|response to radiation|antigen processing and presentation of exogenous antigen|transport|cell cycle process|receptor internalization|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|substrate adhesion-dependent cell spreading|multicellular organism development|regulation of vesicle-mediated transport|animal organ development|regulation of cellular component size|receptor binding|cellular nitrogen compound metabolic process|anion binding|cell-substrate adherens junction|microtubule|small molecule metabolic process|regulation of cell adhesion|adherens junction|reactive nitrogen species metabolic process|nucleoside binding|positive regulation of ion transport|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|growth cone|cellular response to stress|hydrolase activity, acting on acid anhydrides|postsynaptic membrane|regulation of cellular response to growth factor stimulus|cellular component assembly|positive regulation of cell death|positive regulation of endocytosis|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|vesicle membrane|ruffle|response to transforming growth factor beta|protein complex binding|reactive oxygen species metabolic process|establishment of organelle localization|photoreceptor inner segment|neuron projection|cell-substrate adhesion|endocytic vesicle membrane|regulation of signal transduction|lamellipodium|establishment of protein localization|positive regulation of lamellipodium assembly|postsynaptic density|phagocytic cup|response to oxidative stress|protein domain specific binding|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|cell communication|transmembrane transport|membrane organization|gamete generation|regulation of cell projection assembly|signal transduction|developmental cell growth|negative regulation of signal transduction|extracellular exosome|regulation of developmental growth|cardiac septum development|establishment of localization in cell|positive regulation of cell adhesion|cytoskeletal protein binding|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|cell death|leading edge membrane|regulation of catalytic activity|antigen processing and presentation of peptide antigen|nucleotide binding|cellular potassium ion transport|cell projection organization|cell projection membrane|phosphatidylinositol 3-kinase binding|cellular developmental process|response to inorganic substance|cellular biosynthetic process|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|endomembrane system organization|positive regulation of transporter activity|Golgi apparatus|endosome|organelle organization|cardiac chamber development|developmental growth involved in morphogenesis|vesicle-mediated transport|establishment of vesicle localization|tubulin binding|cell morphogenesis|response to carbon monoxide|phagocytosis|cytosol|neuron projection development|centrosome|G-protein coupled receptor signaling pathway|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|trans-Golgi network|phosphatidylinositol 3-kinase regulatory subunit binding|male gamete generation|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|mitotic cell cycle process|vasculature development|positive regulation of substrate adhesion-dependent cell spreading|Golgi organization|cardiovascular system development|cytoplasmic vesicle|positive regulation of hydrolase activity|G-protein coupled receptor internalization|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of membrane tubulation|positive regulation of cell development|coronary vasculature development|regulation of RNA metabolic process|SH3 domain binding|microtubule organizing center|purine nucleoside binding|nitric-oxide synthase binding|cell cycle phase transition|protein transport|synaptic vesicle transport|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|microtubule binding|cellular response to organonitrogen compound|positive regulation of gene expression|positive regulation of ion transmembrane transport|response to nitric oxide|WW domain binding|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|response to catecholamine|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|regulation of reactive oxygen species metabolic process|mitotic cell cycle|artery development|cellular response to transforming growth factor beta stimulus|intracellular transport|ion transport|ribonucleoside binding|nitric oxide metabolic process|positive regulation of reactive oxygen species biosynthetic process|response to alkaloid|cardiac ventricle development|response to monoamine|cell projection assembly|cellular response to oxidative stress|regulation of cell size|cellular response to radiation|negative regulation of G-protein coupled receptor protein signaling pathway|regulation of endocytosis|regulation of cell-substrate adhesion|perinuclear region of cytoplasm|response to growth factor|membrane-bounded vesicle|regulation of ion transmembrane transport|regulation of nitric oxide biosynthetic process|G-protein coupled receptor binding|regulation of cell morphogenesis|positive regulation of phagocytosis|regulation of ion transport|positive regulation of potassium ion transport|ruffle membrane|regulation of oxidoreductase activity|kinase binding|programmed cell death|response to organic cyclic compound|response to reactive oxygen species|lamellipodium organization|response to ionizing radiation|intracellular signal transduction|cytoplasmic vesicle membrane|response to ammonium ion|cellular response to inorganic substance|regulation of organelle organization|regulation of lamellipodium assembly|gene expression|positive regulation of sodium ion transport|regulation of axon extension|cell part morphogenesis|regulation of substrate adhesion-dependent cell spreading|nervous system development|cellular response to organic substance|Golgi membrane|positive regulation of ion transmembrane transporter activity|purine nucleotide binding|vesicle localization|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|potassium ion transmembrane transport|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|positive regulation of cell-substrate adhesion|cell differentiation|cell projection morphogenesis|ventricular septum development|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|response to cocaine|regulation of programmed cell death|neuron projection extension|regulation of reactive oxygen species biosynthetic process|regulation of transmembrane transporter activity|regulation of nervous system development|focal adhesion|antigen processing and presentation of peptide antigen via MHC class II|ion transmembrane transport|positive regulation of reactive oxygen species metabolic process|receptor metabolic process|neuron development|neuron differentiation|transferrin transport|cilium morphogenesis|positive regulation of ATPase activity|spermatogenesis|guanyl ribonucleotide binding|positive regulation of transcription, DNA-templated|cation transmembrane transport|regulation of neuron projection development|lamellipodium assembly|positive regulation of lamellipodium organization|regulation of potassium ion transmembrane transport|positive regulation of apoptotic process|cellular response to ammonium ion|regulation of phagocytosis|endocytic vesicle|regulation of cell morphogenesis involved in differentiation|cellular response to carbon monoxide|G2/M transition of mitotic cell cycle|RNA biosynthetic process|mitotic cell cycle phase transition|cation transport|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|dopamine receptor binding|Golgi vesicle transport|cellular response to reactive nitrogen species|cellular response to organic cyclic compound|transforming growth factor beta receptor signaling pathway|regulation of Golgi organization|axon development|negative regulation of transforming growth factor beta receptor signaling pathway|cytosolic transport|cellular response to nitric oxide|regulation of ion transmembrane transporter activity|enzyme linked receptor protein signaling pathway|coated vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class II|microtubule cytoskeleton|membrane tubulation|positive regulation of sodium ion transmembrane transport|regulation of apoptotic process|aorta development|positive regulation of nitric oxide biosynthetic process|positive regulation of sodium ion transmembrane transporter activity|GTP binding|cellular response to ionizing radiation|endocytosis|regulation of small GTPase mediated signal transduction|response to X-ray|cellular response to reactive oxygen species|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|regulation of neurogenesis|neuron projection morphogenesis|guanyl nucleotide binding|positive regulation of potassium ion transmembrane transport|pyrophosphatase activity|desensitization of G-protein coupled receptor protein signaling pathway|cellular response to catecholamine stimulus|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|axon extension|regulation of ATPase activity|positive regulation of potassium ion transmembrane transporter activity|clathrin-coated vesicle|regulation of potassium ion transmembrane transporter activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of potassium ion transport|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|positive regulation of sodium:potassium-exchanging ATPase activity|cellular response to dopamine|D2 dopamine receptor binding|receptor-mediated endocytosis|regulation of nitric-oxide synthase activity|regulation of sodium ion transport|regulation of sodium ion transmembrane transport|metal ion transport|regulation of sodium ion transmembrane transporter activity|transmembrane receptor protein serine/threonine kinase signaling pathway|pinocytosis|post-Golgi vesicle-mediated transport|clathrin-coated endocytic vesicle|regulation of axonogenesis|cellular response to X-ray|regulation of neuron differentiation|monovalent inorganic cation transport|potassium ion transport|sodium ion transmembrane transport|sodium ion transport|Rac protein signal transduction|GTPase activity|macropinocytosis|regulation of Rac protein signal transduction|Golgi to plasma membrane transport|iron ion transport K01528 dynamin GTPase[3.6.5.5] hsa04144|hsa04072|hsa05100 Endocytosis - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Bacterial invasion of epithelial cells - Homo sapiens (human) 19:10718079-10833488 1141 1206 1898 2777 3157 3498 3.40551641634891 3.27133367113879 5.10749390367665 7.42627412466522 7.73107621636719 9.78466922992295 3.92811466372145 8.31400652365179 -1.0817068366949 1.91867847118289e-06 2.25423955445471e-05 DOWN ENSG00000144840 RABL3 RAB, member of RAS oncogene family-like 3 [Source:HGNC Symbol;Acc:HGNC:18072] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0005622|GO:0006810|GO:0043168|GO:0001882|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0000166|GO:0035639|GO:0001883|GO:0015031|GO:0032549|GO:0035556|GO:0017076|GO:0032561|GO:0005525|GO:0007264|GO:0019001 signaling|cell|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|intracellular|transport|anion binding|nucleoside binding|establishment of protein localization|protein localization|cell communication|signal transduction|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding - - - - 3:120686681-120742993 177 252 302 647 606 486 1.42244988183263 1.84053625584248 2.18819637179406 4.65871768860067 3.99581302477232 3.6604057837246 1.81706083648972 4.10497883236586 -1.1757680598189 1.9211365450998e-06 2.2562395915582e-05 DOWN ENSG00000010295 IFFO1 intermediate filament family orphan 1 [Source:HGNC Symbol;Acc:HGNC:24970] GO:0005623|GO:0043229|GO:0005622|GO:0005882|GO:0005856|GO:0045111 cell|intracellular organelle|intracellular|intermediate filament|cytoskeleton|intermediate filament cytoskeleton - - - - 12:6538375-6556083 56 52 38 12 19 14 0.262457981047104 0.221489412847785 0.160571074506154 0.050392250134633 0.0730627677275048 0.0614948299734219 0.214839489467014 0.0616499492785199 1.80108758547974 1.93031987410897e-06 2.26613328830708e-05 UP ENSG00000164889 SLC4A2 solute carrier family 4 (anion exchanger), member 2 [Source:HGNC Symbol;Acc:HGNC:11028] GO:0032502|GO:0000003|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0030054|GO:0005488|GO:0022857|GO:0030055|GO:0044702|GO:0019953|GO:0045177|GO:0071944|GO:0032504|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0048609|GO:0048565|GO:0016323|GO:0006810|GO:0035295|GO:0016324|GO:0007275|GO:0005924|GO:0005912|GO:0019899|GO:0042592|GO:0019725|GO:0022891|GO:0055085|GO:0007276|GO:0016021|GO:0048232|GO:0055123|GO:0048878|GO:0006811|GO:0055082|GO:0015075|GO:0005925|GO:0034220|GO:0007283|GO:0006820|GO:0015711|GO:0098656|GO:0015297|GO:0008509|GO:0050801|GO:0006873|GO:0015301|GO:0015701|GO:0015698|GO:0030003|GO:1902476|GO:0006821|GO:0005452|GO:0006885|GO:0030641|GO:0051453 developmental process|reproduction|transporter activity|cell|membrane|cellular process|reproductive process|cell junction|binding|transmembrane transporter activity|cell-substrate junction|single organism reproductive process|sexual reproduction|apical part of cell|cell periphery|multicellular organism reproduction|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|multicellular organismal reproductive process|digestive tract development|basolateral plasma membrane|transport|tube development|apical plasma membrane|multicellular organism development|cell-substrate adherens junction|adherens junction|enzyme binding|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|transmembrane transport|gamete generation|integral component of membrane|male gamete generation|digestive system development|chemical homeostasis|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|focal adhesion|ion transmembrane transport|spermatogenesis|anion transport|organic anion transport|anion transmembrane transport|antiporter activity|anion transmembrane transporter activity|ion homeostasis|cellular ion homeostasis|anion:anion antiporter activity|bicarbonate transport|inorganic anion transport|cellular cation homeostasis|chloride transmembrane transport|chloride transport|inorganic anion exchanger activity|regulation of pH|regulation of cellular pH|regulation of intracellular pH K13855 solute carrier family 4 (anion exchanger), member 2[-] hsa04972|hsa04970|hsa04971|hsa04976 Pancreatic secretion - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Bile secretion - Homo sapiens (human) 7:151057210-151076527 9525 9933 7389 4895 5418 3662 47.8800806836005 45.3785242337379 33.4880456140424 22.0465314228814 22.3458496006903 17.2519089546175 42.2488835104603 20.5480966593964 1.03990845120623 1.93295691321759e-06 2.26833709462256e-05 UP ENSG00000132359 RAP1GAP2 RAP1 GTPase activating protein 2 [Source:HGNC Symbol;Acc:HGNC:29176] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0050794|GO:0043229|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0045595|GO:0048468|GO:0007275|GO:0045596|GO:0032535|GO:0008047|GO:0051128|GO:0043231|GO:0005737|GO:0005635|GO:0043005|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0031965|GO:0050790|GO:0030030|GO:0048869|GO:0050768|GO:0005829|GO:0031175|GO:0005813|GO:0031344|GO:0005096|GO:0051345|GO:0030695|GO:0005815|GO:0010721|GO:0031345|GO:0008361|GO:0048471|GO:0035556|GO:0007399|GO:0030154|GO:1902531|GO:0005856|GO:0005634|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0043087|GO:0043547|GO:0015630|GO:0045665|GO:0051056|GO:0022008|GO:0007264|GO:0050767|GO:0010977|GO:0048699|GO:0045664 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|regulation of cellular process|intracellular organelle|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cell differentiation|cell development|multicellular organism development|negative regulation of cell differentiation|regulation of cellular component size|enzyme activator activity|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|neuron projection|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|nuclear membrane|regulation of catalytic activity|cell projection organization|cellular developmental process|negative regulation of neurogenesis|cytosol|neuron projection development|centrosome|regulation of cell projection organization|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|microtubule organizing center|negative regulation of cell development|negative regulation of cell projection organization|regulation of cell size|perinuclear region of cytoplasm|intracellular signal transduction|nervous system development|cell differentiation|regulation of intracellular signal transduction|cytoskeleton|nucleus|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|regulation of GTPase activity|positive regulation of GTPase activity|microtubule cytoskeleton|negative regulation of neuron differentiation|regulation of small GTPase mediated signal transduction|neurogenesis|small GTPase mediated signal transduction|regulation of neurogenesis|negative regulation of neuron projection development|generation of neurons|regulation of neuron differentiation - - - - 17:2777056-3037739 212 231 481 718 875 784 1.03665451510085 1.02657245990066 2.12059141465168 3.14571500999711 3.51053590403433 3.59287864191334 1.3946061298844 3.41637651864826 -1.29260925504657 1.9341437623428e-06 2.26883803068691e-05 DOWN ENSG00000103494 RPGRIP1L RPGRIP1-like [Source:HGNC Symbol;Acc:HGNC:29168] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0050794|GO:0043229|GO:0023051|GO:0005911|GO:0009653|GO:0016043|GO:0023057|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0007507|GO:0090102|GO:0001822|GO:0009888|GO:0007164|GO:0035295|GO:0048839|GO:0005930|GO:0007275|GO:0048513|GO:0005102|GO:0030902|GO:0030900|GO:0007420|GO:0022607|GO:0005737|GO:0007389|GO:0060322|GO:0007423|GO:0022038|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0072372|GO:0021988|GO:0036064|GO:0010646|GO:0007163|GO:0007154|GO:0022037|GO:0021772|GO:0007165|GO:0021670|GO:0009968|GO:0035869|GO:0030030|GO:0021549|GO:0048869|GO:0021537|GO:0043296|GO:0048732|GO:0006996|GO:0000902|GO:0005829|GO:0005813|GO:0060039|GO:0007186|GO:0043584|GO:0007166|GO:0001654|GO:0002009|GO:0072358|GO:0007417|GO:0001655|GO:0043583|GO:0008277|GO:0060541|GO:0005815|GO:0008589|GO:0009790|GO:0001736|GO:0001889|GO:0044782|GO:0072001|GO:0003002|GO:0021532|GO:0030031|GO:0045744|GO:0001664|GO:0070925|GO:0060429|GO:0042384|GO:0035108|GO:0021591|GO:0032990|GO:0007399|GO:0048858|GO:0060173|GO:0005923|GO:0072359|GO:0005856|GO:0031513|GO:0060271|GO:0009792|GO:0043010|GO:0007224|GO:0015630|GO:0009855|GO:0035136|GO:0035137|GO:0030326|GO:0001738|GO:0035115|GO:0035116|GO:0007368|GO:0043009|GO:0031870|GO:0001701 developmental process|signaling|cell|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|regulation of cellular process|intracellular organelle|regulation of signaling|cell-cell junction|anatomical structure morphogenesis|cellular component organization|negative regulation of signaling|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|heart development|cochlea development|kidney development|tissue development|establishment of tissue polarity|tube development|inner ear development|axoneme|multicellular organism development|animal organ development|receptor binding|hindbrain development|forebrain development|brain development|cellular component assembly|cytoplasm|pattern specification process|head development|sensory organ development|corpus callosum development|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|primary cilium|olfactory lobe development|ciliary basal body|regulation of cell communication|establishment or maintenance of cell polarity|cell communication|metencephalon development|olfactory bulb development|signal transduction|lateral ventricle development|negative regulation of signal transduction|ciliary transition zone|cell projection organization|cerebellum development|cellular developmental process|telencephalon development|apical junction complex|gland development|organelle organization|cell morphogenesis|cytosol|centrosome|pericardium development|G-protein coupled receptor signaling pathway|nose development|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|cardiovascular system development|central nervous system development|urogenital system development|ear development|regulation of G-protein coupled receptor protein signaling pathway|respiratory system development|microtubule organizing center|regulation of smoothened signaling pathway|embryo development|establishment of planar polarity|liver development|cilium organization|renal system development|regionalization|neural tube patterning|cell projection assembly|negative regulation of G-protein coupled receptor protein signaling pathway|G-protein coupled receptor binding|organelle assembly|epithelium development|cilium assembly|limb morphogenesis|ventricular system development|cell part morphogenesis|nervous system development|cell projection morphogenesis|limb development|bicellular tight junction|circulatory system development|cytoskeleton|nonmotile primary cilium|cilium morphogenesis|embryo development ending in birth or egg hatching|camera-type eye development|smoothened signaling pathway|microtubule cytoskeleton|determination of bilateral symmetry|forelimb morphogenesis|hindlimb morphogenesis|embryonic limb morphogenesis|morphogenesis of a polarized epithelium|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|determination of left/right symmetry|chordate embryonic development|thromboxane A2 receptor binding|in utero embryonic development - - - - 16:53597683-53703938 239 237 297 523 666 558 0.923577358400643 0.832347501633288 1.03477633599404 1.81082020457054 2.11163227227724 2.02087407955713 0.930233732009324 1.98110885213497 -1.09064299062821 1.94644708027037e-06 2.28237357165717e-05 DOWN ENSG00000180385 EMC3-AS1 EMC3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49223] - - - - - - 3:9986893-10006990 11 11 13 35 105 46 0.138625035258198 0.125991581601218 0.147707340420525 0.395195735599705 1.08569810006325 0.543291799595054 0.137441319093314 0.674728545086003 -2.29549140990375 1.94734502508887e-06 2.28252997169231e-05 DOWN ENSG00000163683 SMIM14 small integral membrane protein 14 [Source:HGNC Symbol;Acc:HGNC:27321] GO:0005623|GO:0016020|GO:0043229|GO:0042175|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0043231|GO:0005737|GO:0005783|GO:0016021 cell|membrane|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane - - - - 4:39546330-39639090 1272 1569 1766 2972 3197 5480 9.31731039762312 10.4449548602412 11.6629494562112 19.5051823800891 19.213839429258 37.6194997418872 10.4750715713585 25.4461738504114 -1.28048864418466 1.97141107592327e-06 2.30983148589534e-05 DOWN ENSG00000180869 LINC01555 long intergenic non-protein coding RNA 1555 [Source:HGNC Symbol;Acc:HGNC:26647] - - - - - - 1:84628230-84635020 9 10 8 0 0 1 0.220747294385553 0.222910201383736 0.176915539519316 0 0 0.0229839616427594 0.206857678429535 0.00766132054758647 4.75490161581144 1.97392356679345e-06 2.31186795461167e-05 UP ENSG00000141086 CTRL chymotrypsin-like [Source:HGNC Symbol;Acc:HGNC:2524] GO:0005576|GO:0008152|GO:0003824|GO:0071704|GO:0016787|GO:0005615|GO:0008233|GO:0007586|GO:0019538|GO:0017171|GO:0006508|GO:0008236|GO:0004252|GO:0004175 extracellular region|metabolic process|catalytic activity|organic substance metabolic process|hydrolase activity|extracellular space|peptidase activity|digestion|protein metabolic process|serine hydrolase activity|proteolysis|serine-type peptidase activity|serine-type endopeptidase activity|endopeptidase activity K09632 chymotrypsin-like protease [EC:3.4.21.-][-] hsa04972|hsa04974 Pancreatic secretion - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human) 16:67927640-67932414 32 27 14 6 4 2 0.363339732943672 0.278617589212319 0.143321465161154 0.0610409495410928 0.0372611023498464 0.0212795330265548 0.261759595772382 0.0398605283058313 2.71520968878933 1.99693114633337e-06 2.33789735069162e-05 UP ENSG00000189056 RELN reelin [Source:HGNC Symbol;Acc:HGNC:9957] GO:0040011|GO:0032502|GO:0031012|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0050794|GO:0040012|GO:0005578|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0050795|GO:0048870|GO:0023051|GO:1900273|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0044708|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0051272|GO:0050804|GO:0042391|GO:0006935|GO:0045595|GO:0006725|GO:0048468|GO:0006810|GO:0021766|GO:0051130|GO:1901360|GO:0007275|GO:0048513|GO:0050877|GO:0005102|GO:0016358|GO:0034641|GO:0030900|GO:0021517|GO:0043270|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0007420|GO:0050806|GO:0051668|GO:0050803|GO:0045597|GO:0043169|GO:0008233|GO:0005737|GO:0007389|GO:0007267|GO:0060322|GO:0021987|GO:0006928|GO:0043005|GO:0009966|GO:0036477|GO:0010646|GO:0006139|GO:0043085|GO:0008104|GO:0007154|GO:0055085|GO:0060996|GO:0061024|GO:0051270|GO:0033555|GO:0016477|GO:0007165|GO:0050808|GO:0007611|GO:0021543|GO:0050790|GO:0030030|GO:0021819|GO:0048869|GO:2000145|GO:0021537|GO:0009967|GO:0044249|GO:0010469|GO:0019538|GO:0031323|GO:0032411|GO:0051090|GO:0017171|GO:1902533|GO:0043113|GO:0032268|GO:0000902|GO:0060998|GO:0031175|GO:0022029|GO:0031344|GO:2000463|GO:0010468|GO:0034645|GO:0048167|GO:0046872|GO:0007166|GO:0060997|GO:0043412|GO:0050807|GO:0050773|GO:0007417|GO:0007612|GO:0010720|GO:0097061|GO:0048813|GO:0090129|GO:0051252|GO:0021510|GO:0060078|GO:0070325|GO:0021761|GO:0031346|GO:0000904|GO:0010628|GO:0030334|GO:0034767|GO:0051347|GO:0021885|GO:0051968|GO:0036211|GO:0007613|GO:2000969|GO:0001764|GO:0006811|GO:0060999|GO:0051091|GO:0003002|GO:0072657|GO:0050769|GO:0051966|GO:0030425|GO:0051247|GO:0006508|GO:0034765|GO:0022604|GO:0035418|GO:0016301|GO:0043269|GO:0034613|GO:0032270|GO:0060291|GO:0021795|GO:0008236|GO:0006796|GO:0048265|GO:0035556|GO:0001941|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0072578|GO:0007399|GO:1900451|GO:0050890|GO:0097485|GO:0032414|GO:0098815|GO:0031328|GO:0051246|GO:0010770|GO:0009059|GO:0030154|GO:0048858|GO:1900006|GO:0030335|GO:1902531|GO:0016070|GO:0016773|GO:0060074|GO:0010557|GO:0022898|GO:0051960|GO:2000273|GO:0034220|GO:0048666|GO:0008347|GO:0030182|GO:0007411|GO:0032006|GO:0021800|GO:0045893|GO:2001222|GO:0010975|GO:2000310|GO:0031401|GO:0007215|GO:0061003|GO:0010001|GO:0031929|GO:0021799|GO:0010769|GO:0014068|GO:0032774|GO:0008306|GO:0032008|GO:2001141|GO:0016310|GO:0050775|GO:0038026|GO:0061564|GO:0097120|GO:0048017|GO:0032412|GO:2001224|GO:2000311|GO:0048814|GO:0032793|GO:0090128|GO:0004672|GO:1900271|GO:0007616|GO:0051057|GO:0060079|GO:0014066|GO:0051056|GO:0021511|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050767|GO:0048812|GO:0097119|GO:0010976|GO:0061001|GO:0043549|GO:0006351|GO:0097114|GO:0006355|GO:0070326|GO:0033674|GO:0045666|GO:0045859|GO:0048015|GO:0045860|GO:0007409|GO:0006468|GO:1902078|GO:0048699|GO:0004712|GO:1903506|GO:0021801|GO:0042325|GO:0001932|GO:0018193|GO:0042063|GO:0001934|GO:0097476|GO:0045664|GO:0042327|GO:0007268|GO:0050731|GO:0050730|GO:0061097|GO:0007270|GO:0097477|GO:0014065|GO:0061098|GO:0018108|GO:0035249 locomotion|developmental process|extracellular matrix|behavior|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|regulation of behavior|cell motility|regulation of signaling|positive regulation of long-term synaptic potentiation|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|single-organism behavior|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|extracellular space|regulation of developmental process|intracellular|protein binding|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of cellular component movement|modulation of synaptic transmission|regulation of membrane potential|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|transport|hippocampus development|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|animal organ development|neurological system process|receptor binding|dendrite development|cellular nitrogen compound metabolic process|forebrain development|ventral spinal cord development|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|brain development|positive regulation of synaptic transmission|localization within membrane|regulation of synapse structure or activity|positive regulation of cell differentiation|cation binding|peptidase activity|cytoplasm|pattern specification process|cell-cell signaling|head development|cerebral cortex development|movement of cell or subcellular component|neuron projection|regulation of signal transduction|somatodendritic compartment|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|cell communication|transmembrane transport|dendritic spine development|membrane organization|regulation of cellular component movement|multicellular organismal response to stress|cell migration|signal transduction|synapse organization|learning or memory|pallium development|regulation of catalytic activity|cell projection organization|layer formation in cerebral cortex|cellular developmental process|regulation of cell motility|telencephalon development|positive regulation of signal transduction|cellular biosynthetic process|regulation of receptor activity|protein metabolic process|regulation of cellular metabolic process|positive regulation of transporter activity|regulation of sequence-specific DNA binding transcription factor activity|serine hydrolase activity|positive regulation of intracellular signal transduction|receptor clustering|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|neuron projection development|telencephalon cell migration|regulation of cell projection organization|positive regulation of excitatory postsynaptic potential|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of synaptic plasticity|metal ion binding|cell surface receptor signaling pathway|dendritic spine morphogenesis|macromolecule modification|regulation of synapse organization|regulation of dendrite development|central nervous system development|learning|positive regulation of cell development|dendritic spine organization|dendrite morphogenesis|positive regulation of synapse maturation|regulation of RNA metabolic process|spinal cord development|regulation of postsynaptic membrane potential|lipoprotein particle receptor binding|limbic system development|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|positive regulation of gene expression|regulation of cell migration|positive regulation of ion transmembrane transport|positive regulation of transferase activity|forebrain cell migration|positive regulation of synaptic transmission, glutamatergic|protein modification process|memory|positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|neuron migration|ion transport|positive regulation of dendritic spine development|positive regulation of sequence-specific DNA binding transcription factor activity|regionalization|protein localization to membrane|positive regulation of neurogenesis|regulation of synaptic transmission, glutamatergic|dendrite|positive regulation of protein metabolic process|proteolysis|regulation of ion transmembrane transport|regulation of cell morphogenesis|protein localization to synapse|kinase activity|regulation of ion transport|cellular protein localization|positive regulation of cellular protein metabolic process|long-term synaptic potentiation|cerebral cortex cell migration|serine-type peptidase activity|phosphate-containing compound metabolic process|response to pain|intracellular signal transduction|postsynaptic membrane organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|neurotransmitter-gated ion channel clustering|nervous system development|positive regulation of glutamate receptor signaling pathway|cognition|neuron projection guidance|positive regulation of ion transmembrane transporter activity|modulation of excitatory postsynaptic potential|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of dendrite development|positive regulation of cell migration|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|synapse maturation|positive regulation of macromolecule biosynthetic process|regulation of transmembrane transporter activity|regulation of nervous system development|positive regulation of receptor activity|ion transmembrane transport|neuron development|glial cell migration|neuron differentiation|axon guidance|regulation of TOR signaling|cerebral cortex tangential migration|positive regulation of transcription, DNA-templated|regulation of neuron migration|regulation of neuron projection development|regulation of N-methyl-D-aspartate selective glutamate receptor activity|positive regulation of protein modification process|glutamate receptor signaling pathway|positive regulation of dendritic spine morphogenesis|glial cell differentiation|TOR signaling|cerebral cortex radially oriented cell migration|regulation of cell morphogenesis involved in differentiation|positive regulation of phosphatidylinositol 3-kinase signaling|RNA biosynthetic process|associative learning|positive regulation of TOR signaling|regulation of RNA biosynthetic process|phosphorylation|positive regulation of dendrite morphogenesis|reelin-mediated signaling pathway|axon development|receptor localization to synapse|inositol lipid-mediated signaling|regulation of ion transmembrane transporter activity|positive regulation of neuron migration|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of dendrite morphogenesis|positive regulation of CREB transcription factor activity|regulation of synapse maturation|protein kinase activity|regulation of long-term synaptic potentiation|long-term memory|positive regulation of small GTPase mediated signal transduction|excitatory postsynaptic potential|regulation of phosphatidylinositol 3-kinase signaling|regulation of small GTPase mediated signal transduction|spinal cord patterning|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|postsynaptic density protein 95 clustering|positive regulation of neuron projection development|regulation of dendritic spine morphogenesis|regulation of kinase activity|transcription, DNA-templated|NMDA glutamate receptor clustering|regulation of transcription, DNA-templated|very-low-density lipoprotein particle receptor binding|positive regulation of kinase activity|positive regulation of neuron differentiation|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|positive regulation of lateral motor column neuron migration|generation of neurons|protein serine/threonine/tyrosine kinase activity|regulation of nucleic acid-templated transcription|cerebral cortex radial glia guided migration|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|gliogenesis|positive regulation of protein phosphorylation|spinal cord motor neuron migration|regulation of neuron differentiation|positive regulation of phosphorylation|synaptic transmission|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|neuron-neuron synaptic transmission|lateral motor column neuron migration|phosphatidylinositol 3-kinase signaling|positive regulation of protein tyrosine kinase activity|peptidyl-tyrosine phosphorylation|synaptic transmission, glutamatergic K06249 reelin [EC:3.4.21.-][-] hsa04151|hsa04510|hsa04512 PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 7:103471784-103989516 33 25 33 112 122 73 0.154918168881922 0.106663988361734 0.13967629026511 0.471090988791963 0.469911954725082 0.321176935447773 0.133752815836255 0.420726626321606 -1.65331385991027 2.00642743044038e-06 2.34809425748206e-05 DOWN ENSG00000198171 DDRGK1 DDRGK domain containing 1 [Source:HGNC Symbol;Acc:HGNC:16110] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0005737|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0005783|GO:0009725|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0051090|GO:1902533|GO:0032268|GO:0045732|GO:0010468|GO:0034645|GO:0033993|GO:0043412|GO:0030163|GO:0051252|GO:0044265|GO:0010628|GO:0036211|GO:0051091|GO:0051247|GO:0006508|GO:0033143|GO:0032270|GO:0014070|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0042176|GO:0010467|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0009755|GO:1902531|GO:0016070|GO:0034976|GO:0032870|GO:0010557|GO:0048545|GO:0030522|GO:0044389|GO:0043401|GO:0044257|GO:0045893|GO:0031401|GO:0043122|GO:0010498|GO:0032774|GO:1903364|GO:0030162|GO:2001141|GO:0045862|GO:0016310|GO:0051092|GO:0071383|GO:0071407|GO:0030518|GO:0051603|GO:0043123|GO:0007249|GO:0006464|GO:0071396|GO:0006351|GO:0006355|GO:0033146|GO:0030520|GO:1903052|GO:0006468|GO:1903506|GO:1901800|GO:0042325|GO:0001932|GO:0007252|GO:0001934|GO:1903721|GO:0061136|GO:0042327|GO:0032446|GO:0071569|GO:1990592 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|endoplasmic reticulum|response to hormone|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|macromolecule modification|protein catabolic process|regulation of RNA metabolic process|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of protein metabolic process|proteolysis|regulation of intracellular steroid hormone receptor signaling pathway|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|regulation of intracellular signal transduction|RNA metabolic process|response to endoplasmic reticulum stress|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to steroid hormone|intracellular receptor signaling pathway|ubiquitin-like protein ligase binding|steroid hormone mediated signaling pathway|cellular protein catabolic process|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|proteasomal protein catabolic process|RNA biosynthetic process|positive regulation of cellular protein catabolic process|regulation of proteolysis|regulation of RNA biosynthetic process|positive regulation of proteolysis|phosphorylation|positive regulation of NF-kappaB transcription factor activity|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|proteolysis involved in cellular protein catabolic process|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of intracellular estrogen receptor signaling pathway|intracellular estrogen receptor signaling pathway|positive regulation of proteolysis involved in cellular protein catabolic process|protein phosphorylation|regulation of nucleic acid-templated transcription|positive regulation of proteasomal protein catabolic process|regulation of phosphorylation|regulation of protein phosphorylation|I-kappaB phosphorylation|positive regulation of protein phosphorylation|positive regulation of I-kappaB phosphorylation|regulation of proteasomal protein catabolic process|positive regulation of phosphorylation|protein modification by small protein conjugation|protein ufmylation|protein K69-linked ufmylation - - - - 20:3190350-3204685 2185 2203 1637 1129 1163 754 62.247291322874 57.0379135935542 42.0467047161875 28.8177922513752 27.1842186406711 20.1311832483227 53.7773032108719 25.377731380123 1.08343430320021 2.01896637615095e-06 2.36184256244555e-05 UP ENSG00000100104 SRRD SRR1 domain containing [Source:HGNC Symbol;Acc:HGNC:33910] GO:0048511 rhythmic process - - - - 22:26483877-26494658 541 610 427 274 275 241 6.74693467385456 6.91384258066786 4.8012213231457 3.0616672338442 2.81390534999539 2.81679109750376 6.15399952588937 2.89745456044778 1.08673829629061 2.02547880573127e-06 2.3677178272652e-05 UP ENSG00000205710 C17orf107 chromosome 17 open reading frame 107 [Source:HGNC Symbol;Acc:HGNC:37238] - - - - - - 17:4899418-4902932 51 39 25 12 9 6 0.806342727476232 0.560401252959674 0.356374145225965 0.169997816558341 0.116749343509933 0.088910368577718 0.574372708553957 0.125219176215331 2.19753168557202 2.02557490816484e-06 2.3677178272652e-05 UP ENSG00000069849 ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide [Source:HGNC Symbol;Acc:HGNC:806] GO:0040011|GO:0032991|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0022857|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0050900|GO:0051641|GO:0048870|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0016787|GO:0031224|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0050817|GO:0042391|GO:0006810|GO:0098797|GO:0044853|GO:0008047|GO:0043270|GO:0031982|GO:0016817|GO:0005887|GO:0043231|GO:0019899|GO:0005737|GO:0009611|GO:0006928|GO:0042592|GO:0090533|GO:0019725|GO:0022891|GO:0031226|GO:0043085|GO:0008104|GO:1902495|GO:0055085|GO:0061024|GO:0016477|GO:0070062|GO:0031647|GO:0050790|GO:0071804|GO:0016021|GO:0098857|GO:0010256|GO:0050878|GO:0032411|GO:0005901|GO:0016820|GO:0086009|GO:0031410|GO:0051345|GO:0050821|GO:0048878|GO:0007596|GO:0051117|GO:0034767|GO:0007009|GO:0016023|GO:0016818|GO:0005890|GO:0042060|GO:0006811|GO:0055082|GO:0015075|GO:0072657|GO:0007599|GO:0031988|GO:0034765|GO:0043269|GO:0034613|GO:0043268|GO:0010765|GO:0032414|GO:0071805|GO:0045121|GO:0060590|GO:0090662|GO:0001671|GO:0022898|GO:0034220|GO:0032781|GO:0098655|GO:1901379|GO:0010248|GO:0072659|GO:0010107|GO:0006812|GO:0032412|GO:0042625|GO:1902307|GO:0050801|GO:0042626|GO:1901381|GO:1990778|GO:0016462|GO:0006873|GO:0043462|GO:0008324|GO:1901018|GO:1901016|GO:0019829|GO:0043266|GO:0017111|GO:0042470|GO:0022890|GO:0002028|GO:1902305|GO:0030001|GO:1903288|GO:0030003|GO:0015672|GO:0016887|GO:0006813|GO:1903278|GO:0035725|GO:0006814|GO:0055065|GO:0006875|GO:0015077|GO:0046873|GO:0015079|GO:0005391|GO:0042623|GO:0030007|GO:0071436|GO:0055075|GO:0006883|GO:0055078|GO:0015081|GO:0043492|GO:0036376 locomotion|macromolecular complex|transporter activity|immune system process|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|transmembrane transporter activity|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|leukocyte migration|cellular localization|cell motility|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|hydrolase activity|intrinsic component of membrane|enzyme regulator activity|intracellular|protein binding|plasma membrane|protein complex|regulation of metabolic process|coagulation|regulation of membrane potential|transport|plasma membrane protein complex|plasma membrane raft|enzyme activator activity|positive regulation of ion transport|vesicle|hydrolase activity, acting on acid anhydrides|integral component of plasma membrane|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|response to wounding|movement of cell or subcellular component|homeostatic process|cation-transporting ATPase complex|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|transmembrane transporter complex|transmembrane transport|membrane organization|cell migration|extracellular exosome|regulation of protein stability|regulation of catalytic activity|cellular potassium ion transport|integral component of membrane|membrane microdomain|endomembrane system organization|regulation of body fluid levels|positive regulation of transporter activity|caveola|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|membrane repolarization|cytoplasmic vesicle|positive regulation of hydrolase activity|protein stabilization|chemical homeostasis|blood coagulation|ATPase binding|positive regulation of ion transmembrane transport|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|sodium:potassium-exchanging ATPase complex|wound healing|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|protein localization to membrane|hemostasis|membrane-bounded vesicle|regulation of ion transmembrane transport|regulation of ion transport|cellular protein localization|positive regulation of potassium ion transport|positive regulation of sodium ion transport|positive regulation of ion transmembrane transporter activity|potassium ion transmembrane transport|membrane raft|ATPase regulator activity|ATP hydrolysis coupled transmembrane transport|ATPase activator activity|regulation of transmembrane transporter activity|ion transmembrane transport|positive regulation of ATPase activity|cation transmembrane transport|regulation of potassium ion transmembrane transport|establishment or maintenance of transmembrane electrochemical gradient|protein localization to plasma membrane|potassium ion import|cation transport|regulation of ion transmembrane transporter activity|ATPase coupled ion transmembrane transporter activity|positive regulation of sodium ion transmembrane transport|ion homeostasis|ATPase activity, coupled to transmembrane movement of substances|positive regulation of potassium ion transmembrane transport|protein localization to cell periphery|pyrophosphatase activity|cellular ion homeostasis|regulation of ATPase activity|cation transmembrane transporter activity|positive regulation of potassium ion transmembrane transporter activity|regulation of potassium ion transmembrane transporter activity|cation-transporting ATPase activity|regulation of potassium ion transport|nucleoside-triphosphatase activity|melanosome|inorganic cation transmembrane transporter activity|regulation of sodium ion transport|regulation of sodium ion transmembrane transport|metal ion transport|positive regulation of potassium ion import|cellular cation homeostasis|monovalent inorganic cation transport|ATPase activity|potassium ion transport|positive regulation of sodium ion export from cell|sodium ion transmembrane transport|sodium ion transport|metal ion homeostasis|cellular metal ion homeostasis|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium ion transmembrane transporter activity|sodium:potassium-exchanging ATPase activity|ATPase activity, coupled|cellular potassium ion homeostasis|sodium ion export|potassium ion homeostasis|cellular sodium ion homeostasis|sodium ion homeostasis|sodium ion transmembrane transporter activity|ATPase activity, coupled to movement of substances|sodium ion export from cell K01540 sodium/potassium-transporting ATPase subunit beta[-] hsa04024|hsa04022|hsa04261|hsa04919|hsa04972|hsa04974|hsa04970|hsa04911|hsa04260|hsa04971|hsa04976|hsa04918|hsa04978|hsa04961|hsa04973|hsa04960|hsa04964 cAMP signaling pathway - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Bile secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Mineral absorption - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)|Carbohydrate digestion and absorption - Homo sapiens (human)|Aldosterone-regulated sodium reabsorption - Homo sapiens (human)|Proximal tubule bicarbonate reclamation - Homo sapiens (human) 3:141876124-141926514 728 945 1284 2423 2586 1745 7.73916730093545 9.13008592405985 12.3067151813136 23.0788464608192 22.5558613208709 17.3855052802376 9.72532280210297 21.0067376873092 -1.11103408935938 2.03289515537955e-06 2.37441517874417e-05 DOWN ENSG00000141551 CSNK1D casein kinase 1, delta [Source:HGNC Symbol;Acc:HGNC:2452] GO:0032502|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0042752|GO:0051716|GO:0042995|GO:0033218|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0051219|GO:0006486|GO:0007049|GO:0006281|GO:0042277|GO:0006725|GO:0051640|GO:0006810|GO:0022402|GO:1901360|GO:0034641|GO:0043168|GO:0005874|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0032922|GO:0051668|GO:0043231|GO:0005737|GO:0006903|GO:0005975|GO:0051656|GO:1990089|GO:0043005|GO:0009966|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0051649|GO:0000166|GO:0030030|GO:0001948|GO:0048869|GO:0009967|GO:0044249|GO:0007017|GO:0019538|GO:0010033|GO:0031323|GO:0010256|GO:0005794|GO:0006996|GO:0016192|GO:0051650|GO:0032268|GO:0030111|GO:0000902|GO:0005829|GO:0045732|GO:0005813|GO:0010468|GO:0034645|GO:0006900|GO:0016050|GO:0007166|GO:0035639|GO:1903047|GO:0043412|GO:0005793|GO:1990090|GO:0006487|GO:0090114|GO:0007010|GO:0007030|GO:0030163|GO:0005815|GO:0001883|GO:0044770|GO:0044265|GO:0033116|GO:0009100|GO:0036211|GO:0044782|GO:0000278|GO:0046907|GO:0048199|GO:0032549|GO:0030031|GO:0051247|GO:0048471|GO:0070848|GO:0006508|GO:0070085|GO:0006259|GO:0005876|GO:0007051|GO:0006461|GO:0016301|GO:0034613|GO:0070925|GO:0032270|GO:0006796|GO:0042384|GO:1901137|GO:0044267|GO:0051174|GO:0042176|GO:0010467|GO:0032990|GO:0071310|GO:0000139|GO:0017076|GO:0051648|GO:0051246|GO:0030177|GO:0009059|GO:0048858|GO:0000226|GO:0016773|GO:0005856|GO:0005634|GO:0005819|GO:0006974|GO:0060271|GO:0016055|GO:0044257|GO:0009101|GO:0051225|GO:0035058|GO:0043413|GO:0033365|GO:0031401|GO:0034622|GO:0010498|GO:0060828|GO:0000086|GO:1903364|GO:0005524|GO:0044772|GO:0048208|GO:0030162|GO:0043623|GO:0045862|GO:0071363|GO:0030554|GO:0018279|GO:0016310|GO:2000052|GO:0048193|GO:0051603|GO:0015630|GO:0007020|GO:0031109|GO:0004672|GO:0006464|GO:0090263|GO:0051258|GO:0035567|GO:1903052|GO:0034067|GO:0019941|GO:0006468|GO:1901800|GO:0060070|GO:0061512|GO:0042325|GO:0044380|GO:0001932|GO:0018193|GO:0004674|GO:0043687|GO:0001934|GO:0046785|GO:0006888|GO:0050321|GO:0061136|GO:0042327|GO:0043161|GO:0006511|GO:0032434|GO:0032436|GO:0018105|GO:0071539 developmental process|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|regulation of circadian rhythm|cellular response to stimulus|cell projection|amide binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|phosphoprotein binding|protein glycosylation|cell cycle|DNA repair|peptide binding|cellular aromatic compound metabolic process|organelle localization|transport|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|microtubule|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|circadian regulation of gene expression|localization within membrane|intracellular membrane-bounded organelle|cytoplasm|vesicle targeting|carbohydrate metabolic process|establishment of organelle localization|response to nerve growth factor|neuron projection|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|membrane organization|signal transduction|establishment of localization in cell|nucleotide binding|cell projection organization|glycoprotein binding|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|microtubule-based process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|organelle organization|vesicle-mediated transport|establishment of vesicle localization|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|positive regulation of protein catabolic process|centrosome|regulation of gene expression|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|cellular response to nerve growth factor stimulus|protein N-linked glycosylation|COPII-coated vesicle budding|cytoskeleton organization|Golgi organization|protein catabolic process|microtubule organizing center|purine nucleoside binding|cell cycle phase transition|cellular macromolecule catabolic process|endoplasmic reticulum-Golgi intermediate compartment membrane|glycoprotein metabolic process|protein modification process|cilium organization|mitotic cell cycle|intracellular transport|vesicle targeting, to, from or within Golgi|ribonucleoside binding|cell projection assembly|positive regulation of protein metabolic process|perinuclear region of cytoplasm|response to growth factor|proteolysis|glycosylation|DNA metabolic process|spindle microtubule|spindle organization|protein complex assembly|kinase activity|cellular protein localization|organelle assembly|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cilium assembly|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|gene expression|cell part morphogenesis|cellular response to organic substance|Golgi membrane|purine nucleotide binding|vesicle localization|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|cell projection morphogenesis|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|spindle|cellular response to DNA damage stimulus|cilium morphogenesis|Wnt signaling pathway|cellular protein catabolic process|glycoprotein biosynthetic process|spindle assembly|nonmotile primary cilium assembly|macromolecule glycosylation|protein localization to organelle|positive regulation of protein modification process|cellular macromolecular complex assembly|proteasomal protein catabolic process|regulation of canonical Wnt signaling pathway|G2/M transition of mitotic cell cycle|positive regulation of cellular protein catabolic process|ATP binding|mitotic cell cycle phase transition|COPII vesicle coating|regulation of proteolysis|cellular protein complex assembly|positive regulation of proteolysis|cellular response to growth factor stimulus|adenyl nucleotide binding|protein N-linked glycosylation via asparagine|phosphorylation|positive regulation of non-canonical Wnt signaling pathway|Golgi vesicle transport|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|microtubule nucleation|microtubule polymerization or depolymerization|protein kinase activity|cellular protein modification process|positive regulation of canonical Wnt signaling pathway|protein polymerization|non-canonical Wnt signaling pathway|positive regulation of proteolysis involved in cellular protein catabolic process|protein localization to Golgi apparatus|modification-dependent protein catabolic process|protein phosphorylation|positive regulation of proteasomal protein catabolic process|canonical Wnt signaling pathway|protein localization to cilium|regulation of phosphorylation|protein localization to cytoskeleton|regulation of protein phosphorylation|peptidyl-amino acid modification|protein serine/threonine kinase activity|post-translational protein modification|positive regulation of protein phosphorylation|microtubule polymerization|ER to Golgi vesicle-mediated transport|tau-protein kinase activity|regulation of proteasomal protein catabolic process|positive regulation of phosphorylation|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|peptidyl-serine phosphorylation|protein localization to centrosome K08959 casein kinase 1, delta[2.7.11.1] hsa04390|hsa04540|hsa04340|hsa04710 Hippo signaling pathway - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human)|Circadian rhythm - Homo sapiens (human) 17:82239023-82273731 657 787 955 1677 1633 1747 2.16158624826901 2.35321851210239 2.8328591195604 4.94354098887876 4.40820154491156 5.38677784304448 2.4492212933106 4.9128401256116 -1.00423416053157 2.03254725640202e-06 2.37441517874417e-05 DOWN ENSG00000137814 HAUS2 HAUS augmin like complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:25530] GO:0032991|GO:0005623|GO:0009987|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0043234|GO:0012505|GO:0007049|GO:0022402|GO:0005874|GO:0022607|GO:0043231|GO:0005737|GO:0005875|GO:0051301|GO:0007017|GO:0005794|GO:0006996|GO:0031023|GO:0005829|GO:0005813|GO:1903047|GO:0007010|GO:0005815|GO:0044770|GO:0000278|GO:0031981|GO:0005654|GO:0005876|GO:0007051|GO:0006461|GO:0070925|GO:0007067|GO:0000226|GO:0005856|GO:0070652|GO:0005634|GO:0005819|GO:0051225|GO:0000086|GO:0044772|GO:0015630|GO:0051297 macromolecular complex|cell|cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein complex|endomembrane system|cell cycle|cell cycle process|microtubule|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|microtubule associated complex|cell division|microtubule-based process|Golgi apparatus|organelle organization|microtubule organizing center organization|cytosol|centrosome|mitotic cell cycle process|cytoskeleton organization|microtubule organizing center|cell cycle phase transition|mitotic cell cycle|nuclear lumen|nucleoplasm|spindle microtubule|spindle organization|protein complex assembly|organelle assembly|mitotic nuclear division|microtubule cytoskeleton organization|cytoskeleton|HAUS complex|nucleus|spindle|spindle assembly|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|microtubule cytoskeleton|centrosome organization - - - - 15:42548810-42569994 707 757 565 366 387 322 5.24884354198558 5.10763842861348 3.78186728872942 2.43457416410128 2.35734286417638 2.24041662973767 4.71278308644283 2.34411121933844 1.00753825859481 2.03597815330984e-06 2.37615683303018e-05 UP ENSG00000148384 INPP5E inositol polyphosphate-5-phosphatase E [Source:HGNC Symbol;Acc:HGNC:21474] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0042995|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0031252|GO:0016787|GO:0009058|GO:0050793|GO:0005622|GO:0005886|GO:0012505|GO:0048856|GO:0005929|GO:0031090|GO:0044262|GO:0044255|GO:0045595|GO:0048468|GO:0051130|GO:0005930|GO:0007275|GO:0043647|GO:0016788|GO:0044281|GO:0019637|GO:0051128|GO:0045597|GO:0043231|GO:0005737|GO:0001726|GO:0005975|GO:0072372|GO:0006629|GO:0030030|GO:0048869|GO:0044249|GO:0005794|GO:0006996|GO:0005829|GO:0031175|GO:0031344|GO:0008654|GO:0046486|GO:0071545|GO:0010720|GO:0006066|GO:0031346|GO:0046855|GO:0050769|GO:0006796|GO:0005795|GO:0008610|GO:0007399|GO:0000139|GO:0046838|GO:0030154|GO:0030258|GO:0046434|GO:0005856|GO:0042578|GO:0006644|GO:0051960|GO:0048666|GO:0030182|GO:0016311|GO:0010975|GO:0046839|GO:0046474|GO:0046164|GO:0031985|GO:0032580|GO:0016791|GO:0022008|GO:0050767|GO:0010976|GO:0006650|GO:0045666|GO:0046488|GO:0048699|GO:0006661|GO:0046856|GO:0052866|GO:0045664|GO:0052745|GO:0046030|GO:0034595|GO:0034593|GO:0004439|GO:0004445 developmental process|cell|membrane|cellular process|metabolic process|catalytic activity|cell projection|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|cell leading edge|hydrolase activity|biosynthetic process|regulation of developmental process|intracellular|plasma membrane|endomembrane system|anatomical structure development|cilium|organelle membrane|cellular carbohydrate metabolic process|cellular lipid metabolic process|regulation of cell differentiation|cell development|positive regulation of cellular component organization|axoneme|multicellular organism development|inositol phosphate metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|ruffle|carbohydrate metabolic process|primary cilium|lipid metabolic process|cell projection organization|cellular developmental process|cellular biosynthetic process|Golgi apparatus|organelle organization|cytosol|neuron projection development|regulation of cell projection organization|phospholipid biosynthetic process|glycerolipid metabolic process|inositol phosphate catabolic process|positive regulation of cell development|alcohol metabolic process|positive regulation of cell projection organization|inositol phosphate dephosphorylation|positive regulation of neurogenesis|phosphate-containing compound metabolic process|Golgi stack|lipid biosynthetic process|nervous system development|Golgi membrane|phosphorylated carbohydrate dephosphorylation|cell differentiation|lipid modification|organophosphate catabolic process|cytoskeleton|phosphoric ester hydrolase activity|phospholipid metabolic process|regulation of nervous system development|neuron development|neuron differentiation|dephosphorylation|regulation of neuron projection development|phospholipid dephosphorylation|glycerophospholipid biosynthetic process|alcohol catabolic process|Golgi cisterna|Golgi cisterna membrane|phosphatase activity|neurogenesis|regulation of neurogenesis|positive regulation of neuron projection development|glycerophospholipid metabolic process|positive regulation of neuron differentiation|phosphatidylinositol metabolic process|generation of neurons|phosphatidylinositol biosynthetic process|phosphatidylinositol dephosphorylation|phosphatidylinositol phosphate phosphatase activity|regulation of neuron differentiation|inositol phosphate phosphatase activity|inositol trisphosphate phosphatase activity|phosphatidylinositol phosphate 5-phosphatase activity|phosphatidylinositol bisphosphate phosphatase activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity K01099 phosphatidylinositol-bisphosphatase[3.1.3.36] hsa01100|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 9:136428619-136439822 458 514 378 211 265 182 9.54552028051981 9.73592637535576 7.10297669993343 3.9401529208756 4.53156437126547 3.5549459370958 8.79480778526967 4.00888774307896 1.13345002756066 2.0359278042218e-06 2.37615683303018e-05 UP ENSG00000104067 TJP1 tight junction protein 1 [Source:HGNC Symbol;Acc:HGNC:11827] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0045177|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0001824|GO:0009888|GO:0048468|GO:0016323|GO:0016324|GO:0007275|GO:0050877|GO:0044291|GO:0097194|GO:0005912|GO:0001825|GO:0022607|GO:0043231|GO:0005737|GO:0007267|GO:0019904|GO:0005516|GO:0007154|GO:0061024|GO:0007165|GO:0005913|GO:0008219|GO:0016327|GO:0048869|GO:0043296|GO:0046581|GO:0005921|GO:0005829|GO:1901350|GO:0045216|GO:0002064|GO:0014704|GO:0009790|GO:0034329|GO:0007600|GO:0012501|GO:0060429|GO:0035556|GO:0006921|GO:0030154|GO:0005923|GO:0005634|GO:0003158|GO:0001885|GO:0009792|GO:0050954|GO:0030855|GO:0035329|GO:0007043|GO:0006915|GO:0061028|GO:0045446|GO:0007605|GO:0043009|GO:0090557|GO:0001701 developmental process|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|apical part of cell|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|blastocyst development|tissue development|cell development|basolateral plasma membrane|apical plasma membrane|multicellular organism development|neurological system process|cell-cell contact zone|execution phase of apoptosis|adherens junction|blastocyst formation|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|protein domain specific binding|calmodulin binding|cell communication|membrane organization|signal transduction|cell-cell adherens junction|cell death|apicolateral plasma membrane|cellular developmental process|apical junction complex|intercellular canaliculus|gap junction|cytosol|cell-cell signaling involved in cell-cell junction organization|cell-cell junction organization|epithelial cell development|intercalated disc|embryo development|cell junction assembly|sensory perception|programmed cell death|epithelium development|intracellular signal transduction|cellular component disassembly involved in execution phase of apoptosis|cell differentiation|bicellular tight junction|nucleus|endothelium development|endothelial cell development|embryo development ending in birth or egg hatching|sensory perception of mechanical stimulus|epithelial cell differentiation|hippo signaling|cell-cell junction assembly|apoptotic process|establishment of endothelial barrier|endothelial cell differentiation|sensory perception of sound|chordate embryonic development|establishment of endothelial intestinal barrier|in utero embryonic development K05701 tight junction protein 1[-] hsa04530|hsa04540|hsa05132|hsa04520|hsa05120|hsa05110 Tight junction - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Vibrio cholerae infection - Homo sapiens (human) 15:29699367-29968865 532 659 1007 1568 1637 1720 2.02050890056887 2.27465033528938 3.44820741079323 5.33572310016056 5.10112589977117 6.12219044026881 2.58112221555049 5.51967981340018 -1.09658612698028 2.04253803709472e-06 2.38288122545627e-05 DOWN ENSG00000110237 ARHGEF17 Rho guanine nucleotide exchange factor 17 [Source:HGNC Symbol;Acc:HGNC:21726] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0016043|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0019222|GO:0010941|GO:0010942|GO:0005737|GO:0005088|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0050790|GO:0030029|GO:0010033|GO:0006996|GO:0005829|GO:0007166|GO:0007010|GO:0051345|GO:0070848|GO:0030036|GO:0012501|GO:0035556|GO:0071310|GO:0005089|GO:0043068|GO:1902531|GO:0043067|GO:0097190|GO:0043065|GO:0071363|GO:0043087|GO:0038179|GO:0043547|GO:0007167|GO:0042981|GO:0051056|GO:0007264|GO:0006915|GO:0048011|GO:0007265|GO:0046578|GO:0007169|GO:0035023|GO:0007266 signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|cellular component organization|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|regulation of cell death|positive regulation of cell death|cytoplasm|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|regulation of catalytic activity|actin filament-based process|response to organic substance|organelle organization|cytosol|cell surface receptor signaling pathway|cytoskeleton organization|positive regulation of hydrolase activity|response to growth factor|actin cytoskeleton organization|programmed cell death|intracellular signal transduction|cellular response to organic substance|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|regulation of programmed cell death|apoptotic signaling pathway|positive regulation of apoptotic process|cellular response to growth factor stimulus|regulation of GTPase activity|neurotrophin signaling pathway|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of apoptotic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|apoptotic process|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction - - - - 11:73308289-73369091 356 393 618 896 1088 1043 2.3113667835362 2.31894815435816 3.61760760979008 5.21223684161198 5.79582677366918 6.34646222939508 2.74930751589481 5.78484194822541 -1.07320925858967 2.05713559199798e-06 2.3980369372709e-05 DOWN ENSG00000189190 ZNF600 zinc finger protein 600 [Source:HGNC Symbol;Acc:HGNC:30951] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:52764195-52818004 173 188 167 83 82 81 1.58825043583364 1.56859348356458 1.38230166331724 0.682732053320852 0.617670397755255 0.696930635055053 1.51304852757182 0.665777695377053 1.1843458156437 2.07400794589407e-06 2.41676163999693e-05 UP ENSG00000281357 ARRDC3-AS1 ARRDC3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44145] - - - - - - 5:91380349-91439085 2 0 1 8 16 18 0.0389394786392321 0 0.017546016465688 0.139566975187084 0.255602750318499 0.328457046600531 0.0188284983683067 0.241208924035371 -3.67929343357973 2.08897608159846e-06 2.43230467784869e-05 DOWN ENSG00000154328 NEIL2 nei-like DNA glycosylase 2 [Source:HGNC Symbol;Acc:HGNC:18956] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0044877|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0016798|GO:0034641|GO:0016788|GO:0005874|GO:0044281|GO:0019637|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0032403|GO:0006139|GO:0055086|GO:0008092|GO:0015631|GO:0003677|GO:0009262|GO:0046872|GO:0043412|GO:0003906|GO:0006284|GO:0008017|GO:0031981|GO:0004518|GO:0005654|GO:0006259|GO:0005876|GO:0006796|GO:0019439|GO:0016799|GO:0006289|GO:0046434|GO:0005856|GO:0005634|GO:0005819|GO:0006974|GO:0006285|GO:0004536|GO:0009117|GO:0006220|GO:0046386|GO:0006304|GO:0003684|GO:0015630|GO:0004519|GO:0046914|GO:0009166|GO:0009264|GO:0004520|GO:0009223|GO:0045008|GO:0008270 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|hydrolase activity, acting on glycosyl bonds|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|microtubule|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein complex binding|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cytoskeletal protein binding|tubulin binding|DNA binding|deoxyribonucleotide metabolic process|metal ion binding|macromolecule modification|DNA-(apurinic or apyrimidinic site) lyase activity|base-excision repair|microtubule binding|nuclear lumen|nuclease activity|nucleoplasm|DNA metabolic process|spindle microtubule|phosphate-containing compound metabolic process|aromatic compound catabolic process|hydrolase activity, hydrolyzing N-glycosyl compounds|nucleotide-excision repair|organophosphate catabolic process|cytoskeleton|nucleus|spindle|cellular response to DNA damage stimulus|base-excision repair, AP site formation|deoxyribonuclease activity|nucleotide metabolic process|pyrimidine nucleotide metabolic process|deoxyribose phosphate catabolic process|DNA modification|damaged DNA binding|microtubule cytoskeleton|endonuclease activity|transition metal ion binding|nucleotide catabolic process|deoxyribonucleotide catabolic process|endodeoxyribonuclease activity|pyrimidine deoxyribonucleotide catabolic process|depyrimidination|zinc ion binding K10568 endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18][-] hsa03410 Base excision repair - Homo sapiens (human) 8:11769639-11787346 271 266 305 148 152 126 2.34376941945994 2.09077177564892 2.37826204259012 1.14684504153947 1.07858840735933 1.02128153427662 2.27093441256633 1.08223832772514 1.06926779908225 2.09644991873283e-06 2.44005519976023e-05 UP ENSG00000108010 GLRX3 glutaredoxin 3 [Source:HGNC Symbol;Acc:HGNC:15987] GO:0009055|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0042995|GO:0097159|GO:0016491|GO:0050794|GO:0043229|GO:0043167|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0030017|GO:0030018|GO:0014741|GO:0005938|GO:0051536|GO:0003676|GO:0031982|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0042592|GO:0043005|GO:0019725|GO:0016667|GO:0036477|GO:0031674|GO:0070062|GO:0002026|GO:0045454|GO:0003013|GO:0055114|GO:0046872|GO:0003723|GO:0090257|GO:0015036|GO:0043292|GO:0030425|GO:0019900|GO:0010611|GO:0014896|GO:0008015|GO:0010614|GO:0005634|GO:0008016|GO:0030016|GO:0060047|GO:0015035|GO:0044822|GO:0019901|GO:0003300|GO:0005080 electron carrier activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cell projection|organic cyclic compound binding|oxidoreductase activity|regulation of cellular process|intracellular organelle|ion binding|membrane-bounded organelle|cell periphery|intracellular|protein binding|sarcomere|Z disc|negative regulation of muscle hypertrophy|cell cortex|iron-sulfur cluster binding|nucleic acid binding|vesicle|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|muscle system process|homeostatic process|neuron projection|cellular homeostasis|oxidoreductase activity, acting on a sulfur group of donors|somatodendritic compartment|I band|extracellular exosome|regulation of the force of heart contraction|cell redox homeostasis|circulatory system process|oxidation-reduction process|metal ion binding|RNA binding|regulation of muscle system process|disulfide oxidoreductase activity|contractile fiber|dendrite|kinase binding|regulation of cardiac muscle hypertrophy|muscle hypertrophy|blood circulation|negative regulation of cardiac muscle hypertrophy|nucleus|regulation of heart contraction|myofibril|heart contraction|protein disulfide oxidoreductase activity|poly(A) RNA binding|protein kinase binding|cardiac muscle hypertrophy|protein kinase C binding - - - - 10:130136399-130184521 641 728 878 1827 1813 1307 7.56587703481797 7.80931365974943 9.34351096100988 19.3213646856096 17.5576807467988 14.4579223741431 8.23956721852576 17.1123226021838 -1.05439511834781 2.10064843000461e-06 2.44398901907083e-05 DOWN ENSG00000155313 USP25 ubiquitin specific peptidase 25 [Source:HGNC Symbol;Acc:HGNC:12624] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0032182|GO:0033554|GO:0043231|GO:0008233|GO:0019899|GO:1903573|GO:0005737|GO:0005783|GO:0019538|GO:0010033|GO:0036503|GO:0036459|GO:0043412|GO:0030163|GO:0032183|GO:0043130|GO:0051117|GO:0044265|GO:0036211|GO:1904455|GO:0006508|GO:0044267|GO:0042176|GO:1904292|GO:1904293|GO:0051246|GO:0042177|GO:0034976|GO:0005634|GO:0044389|GO:0031625|GO:0044257|GO:0051603|GO:0070646|GO:0004843|GO:0008234|GO:0006464|GO:0019941|GO:0016579|GO:0006511|GO:0070536|GO:0071108 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|endomembrane system|regulation of metabolic process|ubiquitin-like protein binding|cellular response to stress|intracellular membrane-bounded organelle|peptidase activity|enzyme binding|negative regulation of response to endoplasmic reticulum stress|cytoplasm|endoplasmic reticulum|protein metabolic process|response to organic substance|ERAD pathway|thiol-dependent ubiquitinyl hydrolase activity|macromolecule modification|protein catabolic process|SUMO binding|ubiquitin binding|ATPase binding|cellular macromolecule catabolic process|protein modification process|ubiquitin-specific protease activity involved in negative regulation of ERAD pathway|proteolysis|cellular protein metabolic process|regulation of protein catabolic process|regulation of ERAD pathway|negative regulation of ERAD pathway|regulation of protein metabolic process|negative regulation of protein catabolic process|response to endoplasmic reticulum stress|nucleus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|protein modification by small protein removal|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|modification-dependent protein catabolic process|protein deubiquitination|ubiquitin-dependent protein catabolic process|protein K63-linked deubiquitination|protein K48-linked deubiquitination - - - - 21:15730025-15880069 205 238 442 649 746 827 1.33478241387493 1.4083558445157 2.59473165967013 3.78615563330972 3.98531412956281 5.04650424051107 1.77928997268692 4.27265800112787 -1.26383219591834 2.11849133766125e-06 2.46282867579981e-05 DOWN ENSG00000126858 RHOT1 ras homolog family member T1 [Source:HGNC Symbol;Acc:HGNC:21168] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0019867|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0031090|GO:0051640|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0006928|GO:0042592|GO:0051656|GO:0009966|GO:0031966|GO:0045184|GO:0019725|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0010970|GO:0007165|GO:0090559|GO:0051649|GO:0008219|GO:0000166|GO:0016021|GO:0007017|GO:0031301|GO:0006996|GO:0051646|GO:0005740|GO:0005829|GO:0046872|GO:0035639|GO:0007005|GO:0005741|GO:0051654|GO:0001883|GO:0015031|GO:0016818|GO:0046902|GO:0046907|GO:0032549|GO:0031306|GO:0007018|GO:0005739|GO:0012501|GO:0032592|GO:0035556|GO:0017076|GO:1902531|GO:0072384|GO:0097190|GO:0007006|GO:0032561|GO:0006839|GO:0047497|GO:0008637|GO:0005509|GO:0097345|GO:1902108|GO:0035794|GO:0005525|GO:0031307|GO:0051056|GO:0007264|GO:0030705|GO:0019001|GO:0016462|GO:0006915|GO:0017111|GO:1902110|GO:0003924 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|outer membrane|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|plasma membrane|organelle membrane|organelle localization|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|movement of cell or subcellular component|homeostatic process|establishment of organelle localization|regulation of signal transduction|mitochondrial membrane|establishment of protein localization|cellular homeostasis|regulation of cell communication|protein localization|cell communication|membrane organization|establishment of localization by movement along microtubule|signal transduction|regulation of membrane permeability|establishment of localization in cell|cell death|nucleotide binding|integral component of membrane|microtubule-based process|integral component of organelle membrane|organelle organization|mitochondrion localization|mitochondrial envelope|cytosol|metal ion binding|purine ribonucleoside triphosphate binding|mitochondrion organization|mitochondrial outer membrane|establishment of mitochondrion localization|purine nucleoside binding|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|regulation of mitochondrial membrane permeability|intracellular transport|ribonucleoside binding|intrinsic component of mitochondrial outer membrane|microtubule-based movement|mitochondrion|programmed cell death|integral component of mitochondrial membrane|intracellular signal transduction|purine nucleotide binding|regulation of intracellular signal transduction|organelle transport along microtubule|apoptotic signaling pathway|mitochondrial membrane organization|guanyl ribonucleotide binding|mitochondrial transport|mitochondrion transport along microtubule|apoptotic mitochondrial changes|calcium ion binding|mitochondrial outer membrane permeabilization|regulation of mitochondrial membrane permeability involved in apoptotic process|positive regulation of mitochondrial membrane permeability|GTP binding|integral component of mitochondrial outer membrane|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|cytoskeleton-dependent intracellular transport|guanyl nucleotide binding|pyrophosphatase activity|apoptotic process|nucleoside-triphosphatase activity|positive regulation of mitochondrial membrane permeability involved in apoptotic process|GTPase activity - - - - 17:32142454-32253374 273 312 415 700 721 757 1.50562585433176 1.56382646566893 2.06355767354763 3.45899907265767 3.26255351230312 3.91272300340857 1.71100333118277 3.54475852945645 -1.05084478513899 2.15882905050299e-06 2.50874591178343e-05 DOWN ENSG00000135637 CCDC142 coiled-coil domain containing 142 [Source:HGNC Symbol;Acc:HGNC:25889] - - - - - - 2:74471986-74483408 271 314 229 110 155 102 1.91562806852832 2.01720923881561 1.45945905778973 0.696676058149659 0.898961341580504 0.675726214602985 1.79743212171122 0.757121204777716 1.24734111009821 2.16298689162085e-06 2.51259963667117e-05 UP ENSG00000140577 CRTC3 CREB regulated transcription coactivator 3 [Source:HGNC Symbol;Acc:HGNC:26148] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0016032|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0042592|GO:0001775|GO:0009966|GO:0048871|GO:0010646|GO:0006139|GO:0007154|GO:0006629|GO:0007165|GO:0009968|GO:0008134|GO:0045833|GO:0044249|GO:0031323|GO:0051090|GO:0010468|GO:0034645|GO:0016042|GO:0051252|GO:0008140|GO:0010628|GO:0050994|GO:0051091|GO:0031981|GO:0050995|GO:0005654|GO:0006461|GO:0042116|GO:0035556|GO:0010467|GO:0097009|GO:0019216|GO:1902532|GO:0031328|GO:0009059|GO:1902531|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0051259|GO:0043951|GO:0032774|GO:2001141|GO:0032793|GO:0019932|GO:0006351|GO:0006355|GO:0043949|GO:0045944|GO:0006366|GO:0019935|GO:0006357|GO:1903506|GO:0051260|GO:0051262|GO:0051289|GO:0019933 immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|viral process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|cell activation|regulation of signal transduction|multicellular organismal homeostasis|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|lipid metabolic process|signal transduction|negative regulation of signal transduction|transcription factor binding|negative regulation of lipid metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of gene expression|cellular macromolecule biosynthetic process|lipid catabolic process|regulation of RNA metabolic process|cAMP response element binding protein binding|positive regulation of gene expression|regulation of lipid catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|nuclear lumen|negative regulation of lipid catabolic process|nucleoplasm|protein complex assembly|macrophage activation|intracellular signal transduction|gene expression|energy homeostasis|regulation of lipid metabolic process|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|protein oligomerization|negative regulation of cAMP-mediated signaling|RNA biosynthetic process|regulation of RNA biosynthetic process|positive regulation of CREB transcription factor activity|second-messenger-mediated signaling|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of cAMP-mediated signaling|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|cyclic-nucleotide-mediated signaling|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|protein homooligomerization|protein tetramerization|protein homotetramerization|cAMP-mediated signaling K16334 CREB-regulated transcription coactivator 3[-] hsa05166 HTLV-I infection - Homo sapiens (human) 15:90529925-90645345 760 886 713 294 501 427 3.90102501681036 4.13312607875853 3.29965771551167 1.35210285786873 2.10994287848422 2.05409905767402 3.77793627036019 1.83871493134232 1.03890053912507 2.17248894568775e-06 2.52167515492076e-05 UP ENSG00000255104 TBC1D26 TBC1 domain family member 26 [Source:HGNC Symbol;Acc:HGNC:28745] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 17:15699692-15744783 13 10 16 1 0 3 0.161327973473789 0.112784740489596 0.179026110867968 0.0111138234211951 0 0.0348872344093253 0.151046274943784 0.0153336859435068 3.30021416335832 2.18086075417593e-06 2.53040874291365e-05 UP ENSG00000111335 OAS2 2'-5'-oligoadenylate synthetase 2 [Source:HGNC Symbol;Acc:HGNC:8087] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0006486|GO:0045087|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0044281|GO:0006952|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0098542|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0009615|GO:0006139|GO:0055086|GO:0007154|GO:0007165|GO:0005783|GO:0051607|GO:0000166|GO:0044249|GO:0019538|GO:0010033|GO:0005829|GO:0034340|GO:0034645|GO:0046872|GO:0003723|GO:0007166|GO:0035639|GO:0043412|GO:0034097|GO:0001883|GO:0044265|GO:0009100|GO:0036211|GO:0032549|GO:0034341|GO:0042157|GO:0048471|GO:0070085|GO:0005739|GO:0006796|GO:1901137|GO:0044267|GO:0071310|GO:0017076|GO:0019439|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0006401|GO:0009101|GO:0043413|GO:0019221|GO:0071346|GO:0009117|GO:0005524|GO:0030554|GO:0071357|GO:0003725|GO:0006163|GO:0042158|GO:0071345|GO:0046914|GO:0006464|GO:0009165|GO:0006164|GO:0001730|GO:0060333|GO:0006497|GO:0008270|GO:0060337|GO:0018377 immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|intracellular|protein binding|endomembrane system|transferase activity|protein glycosylation|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|defense response to other organism|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|response to virus|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|endoplasmic reticulum|defense response to virus|nucleotide binding|cellular biosynthetic process|protein metabolic process|response to organic substance|cytosol|response to type I interferon|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|response to cytokine|purine nucleoside binding|cellular macromolecule catabolic process|glycoprotein metabolic process|protein modification process|ribonucleoside binding|response to interferon-gamma|lipoprotein metabolic process|perinuclear region of cytoplasm|glycosylation|mitochondrion|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|cellular response to organic substance|purine nucleotide binding|aromatic compound catabolic process|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|RNA catabolic process|glycoprotein biosynthetic process|macromolecule glycosylation|cytokine-mediated signaling pathway|cellular response to interferon-gamma|nucleotide metabolic process|ATP binding|adenyl nucleotide binding|cellular response to type I interferon|double-stranded RNA binding|purine nucleotide metabolic process|lipoprotein biosynthetic process|cellular response to cytokine stimulus|transition metal ion binding|cellular protein modification process|nucleotide biosynthetic process|purine nucleotide biosynthetic process|2'-5'-oligoadenylate synthetase activity|interferon-gamma-mediated signaling pathway|protein lipidation|zinc ion binding|type I interferon signaling pathway|protein myristoylation K14216 2'-5'-oligoadenylate synthetase[2.7.7.84] hsa05168|hsa05164|hsa05162|hsa05160 Herpes simplex infection - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Measles - Homo sapiens (human)|Hepatitis C - Homo sapiens (human) 12:112978395-113011723 18 38 34 8 4 8 0.120233276111036 0.230681537205348 0.204757981070304 0.0478797753403851 0.0219203652161986 0.0500808762768788 0.185224264795563 0.0399603389444875 2.21263238200963 2.18378096072398e-06 2.5328126185491e-05 UP ENSG00000164099 PRSS12 protease, serine 12 [Source:HGNC Symbol;Acc:HGNC:9477] GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:0042995|GO:0004872|GO:0043083|GO:0071704|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005886|GO:0006810|GO:0043195|GO:0032940|GO:0031982|GO:0008233|GO:0005737|GO:0043005|GO:0036477|GO:0044306|GO:0019538|GO:0038024|GO:0017171|GO:0016192|GO:0030424|GO:0031410|GO:0051604|GO:0006887|GO:0043679|GO:0030425|GO:0006508|GO:0008236|GO:0010467|GO:0046903|GO:0005044|GO:0004252|GO:0016485|GO:0004175|GO:0006897|GO:0006898|GO:0031638 synapse|cell|membrane|cellular process|extracellular region|metabolic process|catalytic activity|cell projection|receptor activity|synaptic cleft|organic substance metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|plasma membrane|transport|terminal bouton|secretion by cell|vesicle|peptidase activity|cytoplasm|neuron projection|somatodendritic compartment|neuron projection terminus|protein metabolic process|cargo receptor activity|serine hydrolase activity|vesicle-mediated transport|axon|cytoplasmic vesicle|protein maturation|exocytosis|axon terminus|dendrite|proteolysis|serine-type peptidase activity|gene expression|secretion|scavenger receptor activity|serine-type endopeptidase activity|protein processing|endopeptidase activity|endocytosis|receptor-mediated endocytosis|zymogen activation - - - - 4:118280038-118353003 101 96 217 341 385 520 1.11771813094237 0.965516426719442 2.16512361816979 3.38112224334983 3.49572817209837 5.39313033763891 1.41611939194387 4.08999358436237 -1.53015567706627 2.18792401313691e-06 2.53663236847337e-05 DOWN ENSG00000147003 TMEM27 transmembrane protein 27 [Source:HGNC Symbol;Acc:HGNC:29437] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0050794|GO:0051050|GO:0044089|GO:0071704|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0060341|GO:0005903|GO:0046887|GO:0006810|GO:0051130|GO:0061178|GO:0060627|GO:0032940|GO:0043270|GO:0031982|GO:0051128|GO:0022607|GO:0008233|GO:0005737|GO:0007267|GO:0032880|GO:0051222|GO:0042592|GO:0045184|GO:0046883|GO:0019725|GO:0031340|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0035774|GO:0070062|GO:0051649|GO:0051047|GO:0031253|GO:0010817|GO:0016021|GO:0019538|GO:0031334|GO:0043254|GO:0010033|GO:0006996|GO:0061025|GO:0016192|GO:0009743|GO:0016050|GO:0090276|GO:0002793|GO:0048878|GO:0031526|GO:0051223|GO:0015031|GO:0051957|GO:0045921|GO:0006887|GO:0070201|GO:0042886|GO:0006811|GO:0055082|GO:0050714|GO:0017157|GO:0051046|GO:0009914|GO:0009306|GO:0006508|GO:0006461|GO:0035542|GO:0043269|GO:0035773|GO:0033043|GO:0035543|GO:0031338|GO:0046903|GO:0071310|GO:0015837|GO:0048284|GO:0090277|GO:0010638|GO:0008237|GO:0050796|GO:0071322|GO:0002790|GO:0030073|GO:0006820|GO:0015711|GO:0045055|GO:0001678|GO:0034622|GO:0043623|GO:0034284|GO:0050708|GO:0015833|GO:0046942|GO:1903307|GO:0006906|GO:0032024|GO:1903305|GO:0044070|GO:0008238|GO:0006865|GO:0046879|GO:0033500|GO:0071333|GO:0042593|GO:0030072|GO:0017156|GO:0017158|GO:0045956|GO:0008241|GO:0035493|GO:0009749 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|regulation of cellular process|positive regulation of transport|positive regulation of cellular component biogenesis|organic substance metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|plasma membrane|regulation of cellular localization|brush border|positive regulation of hormone secretion|transport|positive regulation of cellular component organization|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of vesicle-mediated transport|secretion by cell|positive regulation of ion transport|vesicle|regulation of cellular component organization|cellular component assembly|peptidase activity|cytoplasm|cell-cell signaling|regulation of protein localization|positive regulation of protein transport|homeostatic process|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|positive regulation of vesicle fusion|regulation of cell communication|protein localization|cell communication|membrane organization|positive regulation of insulin secretion involved in cellular response to glucose stimulus|extracellular exosome|establishment of localization in cell|positive regulation of secretion|cell projection membrane|regulation of hormone levels|integral component of membrane|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|response to organic substance|organelle organization|membrane fusion|vesicle-mediated transport|response to carbohydrate|vesicle organization|regulation of peptide hormone secretion|positive regulation of peptide secretion|chemical homeostasis|brush border membrane|regulation of protein transport|protein transport|positive regulation of amino acid transport|positive regulation of exocytosis|exocytosis|regulation of establishment of protein localization|amide transport|ion transport|cellular chemical homeostasis|positive regulation of protein secretion|regulation of exocytosis|regulation of secretion|hormone transport|protein secretion|proteolysis|protein complex assembly|regulation of SNARE complex assembly|regulation of ion transport|insulin secretion involved in cellular response to glucose stimulus|regulation of organelle organization|positive regulation of SNARE complex assembly|regulation of vesicle fusion|secretion|cellular response to organic substance|amine transport|organelle fusion|positive regulation of peptide hormone secretion|positive regulation of organelle organization|metallopeptidase activity|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|insulin secretion|anion transport|organic anion transport|regulated exocytosis|cellular glucose homeostasis|cellular macromolecular complex assembly|cellular protein complex assembly|response to monosaccharide|regulation of protein secretion|peptide transport|carboxylic acid transport|positive regulation of regulated secretory pathway|vesicle fusion|positive regulation of insulin secretion|regulation of regulated secretory pathway|regulation of anion transport|exopeptidase activity|amino acid transport|hormone secretion|carbohydrate homeostasis|cellular response to glucose stimulus|glucose homeostasis|peptide hormone secretion|calcium ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|positive regulation of calcium ion-dependent exocytosis|peptidyl-dipeptidase activity|SNARE complex assembly|response to glucose - - - - X:15627318-15665031 135 153 142 64 76 43 6.05162338033594 6.23319875966762 5.73904714202685 2.57049830824672 2.79523909499112 1.80648899556013 6.00795642734347 2.39074213293266 1.32941582137993 2.18990395499438e-06 2.53794226212742e-05 UP ENSG00000183621 ZNF438 zinc finger protein 438 [Source:HGNC Symbol;Acc:HGNC:21029] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:1903507|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription - - - - 10:30820207-31031937 14 21 27 67 64 78 0.124570583927448 0.169819341926834 0.21660050688483 0.534132934481486 0.467222536808607 0.650430539649764 0.170330144246371 0.550595336979952 -1.69265861257517 2.20622055167916e-06 2.55585985059486e-05 DOWN ENSG00000175279 APITD1 apoptosis-inducing, TAF9-like domain 1 [Source:HGNC Symbol;Acc:HGNC:23163] GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0007049|GO:0007131|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0000776|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0071821|GO:0043231|GO:0005737|GO:0046983|GO:0003682|GO:0051307|GO:0006139|GO:0031297|GO:0007154|GO:0007165|GO:0007126|GO:0007059|GO:0043240|GO:0051301|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0032268|GO:0005829|GO:0003677|GO:0034645|GO:1903047|GO:0043412|GO:0051304|GO:0046982|GO:0006325|GO:0000712|GO:0036211|GO:0000278|GO:0036297|GO:0007127|GO:0031981|GO:0045132|GO:0051247|GO:0005654|GO:0006259|GO:0005694|GO:0006461|GO:0032270|GO:0035556|GO:0044267|GO:0007067|GO:0051246|GO:0009059|GO:0005634|GO:0000777|GO:0006974|GO:0031401|GO:0006260|GO:0006334|GO:0034622|GO:0000793|GO:0034728|GO:0003690|GO:0034508|GO:0006333|GO:0065004|GO:0006310|GO:0031497|GO:0016568|GO:0007264|GO:0006464|GO:0071103|GO:0000775|GO:0006336|GO:0006323|GO:0043486|GO:0000779|GO:0006261|GO:0006338|GO:0034080|GO:0032446|GO:0031398|GO:0031396|GO:0043044|GO:0016567 macromolecular complex|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cell cycle|reciprocal meiotic recombination|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|kinetochore|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|FANCM-MHF complex|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|chromatin binding|meiotic chromosome separation|nucleobase-containing compound metabolic process|replication fork processing|cell communication|signal transduction|meiotic nuclear division|chromosome segregation|Fanconi anaemia nuclear complex|cell division|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of cellular protein metabolic process|cytosol|DNA binding|cellular macromolecule biosynthetic process|mitotic cell cycle process|macromolecule modification|chromosome separation|protein heterodimerization activity|chromatin organization|resolution of meiotic recombination intermediates|protein modification process|mitotic cell cycle|interstrand cross-link repair|meiosis I|nuclear lumen|meiotic chromosome segregation|positive regulation of protein metabolic process|nucleoplasm|DNA metabolic process|chromosome|protein complex assembly|positive regulation of cellular protein metabolic process|intracellular signal transduction|cellular protein metabolic process|mitotic nuclear division|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|condensed chromosome kinetochore|cellular response to DNA damage stimulus|positive regulation of protein modification process|DNA replication|nucleosome assembly|cellular macromolecular complex assembly|condensed chromosome|nucleosome organization|double-stranded DNA binding|centromere complex assembly|chromatin assembly or disassembly|protein-DNA complex assembly|DNA recombination|chromatin assembly|chromatin modification|small GTPase mediated signal transduction|cellular protein modification process|DNA conformation change|chromosome, centromeric region|DNA replication-independent nucleosome assembly|DNA packaging|histone exchange|condensed chromosome, centromeric region|DNA-dependent DNA replication|chromatin remodeling|CENP-A containing nucleosome assembly|protein modification by small protein conjugation|positive regulation of protein ubiquitination|regulation of protein ubiquitination|ATP-dependent chromatin remodeling|protein ubiquitination K11511 centromere protein S[-] hsa03460 Fanconi anemia pathway - Homo sapiens (human) 1:10430443-10442809 97 101 79 344 328 189 2.2148010911046 2.09588377490119 1.62632859432207 7.03754292976715 6.14478487329503 4.04440195122581 1.97900448677595 5.74224325142933 -1.53683956366472 2.20815104081531e-06 2.55710400203648e-05 DOWN ENSG00000027075 PRKCH protein kinase C, eta [Source:HGNC Symbol;Acc:HGNC:9403] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0005911|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0008284|GO:0002757|GO:0042127|GO:0050817|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0045684|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0045597|GO:0043169|GO:0019899|GO:0005737|GO:0009611|GO:0001775|GO:1901888|GO:0009966|GO:0014009|GO:0060548|GO:0010646|GO:0006139|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0050857|GO:0070062|GO:0008219|GO:0000166|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0031323|GO:0050878|GO:0051090|GO:0005829|GO:0045682|GO:0010468|GO:0060252|GO:0034645|GO:0045216|GO:0030168|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0010720|GO:0043069|GO:0007596|GO:0051252|GO:0001883|GO:0060251|GO:0010628|GO:0036211|GO:0030856|GO:0042060|GO:0010743|GO:0032549|GO:0051091|GO:0034329|GO:0002429|GO:2000810|GO:0010744|GO:0050769|GO:0007599|GO:0030858|GO:0002764|GO:0016301|GO:0043588|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0010467|GO:0007399|GO:0045606|GO:0017076|GO:0031328|GO:0009059|GO:0051020|GO:0030154|GO:0016070|GO:0016773|GO:0010557|GO:0050861|GO:0043067|GO:0051960|GO:0045893|GO:0030855|GO:0032774|GO:0005524|GO:0030216|GO:2001141|GO:0030554|GO:0016310|GO:0051092|GO:0002768|GO:0008544|GO:0045604|GO:0031267|GO:0070528|GO:0045618|GO:0014015|GO:0042981|GO:0050855|GO:0043066|GO:0004672|GO:0022008|GO:0006464|GO:0050851|GO:0050767|GO:0007043|GO:0006351|GO:0006915|GO:0006355|GO:0070830|GO:0045616|GO:0017016|GO:0043297|GO:0006468|GO:0048699|GO:0014013|GO:1903506|GO:0034351|GO:0010742|GO:0018193|GO:0042063|GO:0004674|GO:0034349|GO:0050853|GO:0009913|GO:0017160|GO:0018105|GO:0004697|GO:0004699 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cell-cell junction|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|immune response-activating signal transduction|regulation of cell proliferation|coagulation|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|positive regulation of epidermis development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of cell differentiation|cation binding|enzyme binding|cytoplasm|response to wounding|cell activation|regulation of cell junction assembly|regulation of signal transduction|glial cell proliferation|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|positive regulation of antigen receptor-mediated signaling pathway|extracellular exosome|cell death|nucleotide binding|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|regulation of sequence-specific DNA binding transcription factor activity|cytosol|regulation of epidermis development|regulation of gene expression|positive regulation of glial cell proliferation|cellular macromolecule biosynthetic process|cell-cell junction organization|platelet activation|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|positive regulation of cell development|negative regulation of programmed cell death|blood coagulation|regulation of RNA metabolic process|purine nucleoside binding|regulation of glial cell proliferation|positive regulation of gene expression|protein modification process|regulation of epithelial cell differentiation|wound healing|regulation of macrophage derived foam cell differentiation|ribonucleoside binding|positive regulation of sequence-specific DNA binding transcription factor activity|cell junction assembly|immune response-activating cell surface receptor signaling pathway|regulation of bicellular tight junction assembly|positive regulation of macrophage derived foam cell differentiation|positive regulation of neurogenesis|hemostasis|positive regulation of epithelial cell differentiation|immune response-regulating signaling pathway|kinase activity|skin development|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|nervous system development|positive regulation of epidermal cell differentiation|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|GTPase binding|cell differentiation|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|positive regulation of B cell receptor signaling pathway|regulation of programmed cell death|regulation of nervous system development|positive regulation of transcription, DNA-templated|epithelial cell differentiation|RNA biosynthetic process|ATP binding|keratinocyte differentiation|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|positive regulation of NF-kappaB transcription factor activity|immune response-regulating cell surface receptor signaling pathway|epidermis development|regulation of epidermal cell differentiation|small GTPase binding|protein kinase C signaling|positive regulation of keratinocyte differentiation|positive regulation of gliogenesis|regulation of apoptotic process|regulation of B cell receptor signaling pathway|negative regulation of apoptotic process|protein kinase activity|neurogenesis|cellular protein modification process|antigen receptor-mediated signaling pathway|regulation of neurogenesis|cell-cell junction assembly|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|bicellular tight junction assembly|regulation of keratinocyte differentiation|Ras GTPase binding|apical junction assembly|protein phosphorylation|generation of neurons|regulation of gliogenesis|regulation of nucleic acid-templated transcription|negative regulation of glial cell apoptotic process|macrophage derived foam cell differentiation|peptidyl-amino acid modification|gliogenesis|protein serine/threonine kinase activity|glial cell apoptotic process|B cell receptor signaling pathway|epidermal cell differentiation|Ral GTPase binding|peptidyl-serine phosphorylation|protein kinase C activity|calcium-independent protein kinase C activity K18051 novel protein kinase C eta type[2.7.11.13] hsa04530|hsa04270|hsa04750 Tight junction - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human) 14:61187559-61550976 266 296 524 767 901 888 1.46862231786978 1.48525143735596 2.60840083653444 3.79421471550383 4.08151865205397 4.59484437669418 1.85409153058673 4.15685924808399 -1.16478143193017 2.21638348671236e-06 2.56564221063632e-05 DOWN ENSG00000263235 RP11-461A8.4 - - - - - - - 16:3650636-3651703 120 97 33 16 24 13 7.94796359501235 5.83885648532548 1.97063889673659 0.949465845971264 1.30424742372203 0.806981014429905 5.25248632569147 1.02023142804107 2.36410405250809 2.21731340470733e-06 2.56572381333847e-05 UP ENSG00000234009 RPL5P34 ribosomal protein L5 pseudogene 34 [Source:HGNC Symbol;Acc:HGNC:36463] - - - - - - 22:42776406-42777296 659 691 513 324 357 285 52.3182620243321 49.8569653886587 36.7197601794526 23.046791183257 23.2543451850484 21.20520202263 46.2983291974811 22.5021127969785 1.04089966364854 2.21819426120813e-06 2.56574860418859e-05 UP ENSG00000112039 FANCE Fanconi anemia complementation group E [Source:HGNC Symbol;Acc:HGNC:3586] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0043234|GO:0006281|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0006139|GO:0043240|GO:0036297|GO:0031981|GO:0005654|GO:0006259|GO:0005634|GO:0006974 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein complex|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|Fanconi anaemia nuclear complex|interstrand cross-link repair|nuclear lumen|nucleoplasm|DNA metabolic process|nucleus|cellular response to DNA damage stimulus K10892 fanconi anemia group E protein[-] hsa03460 Fanconi anemia pathway - Homo sapiens (human) 6:35452361-35467103 30 30 109 249 272 187 0.830882204147944 0.755136672816008 2.72186405511254 6.17904749189485 6.18104843583347 4.85394900318799 1.43596097735883 5.7380149769721 -1.99853518968244 2.25227637067803e-06 2.60403674143948e-05 DOWN ENSG00000169371 SNUPN snurportin 1 [Source:HGNC Symbol;Acc:HGNC:14245] GO:0005215|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0006725|GO:0008565|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0031982|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0005635|GO:0045184|GO:0006139|GO:0008104|GO:0070062|GO:0051649|GO:0006403|GO:0022613|GO:0005829|GO:0003723|GO:0072594|GO:0015031|GO:0046907|GO:0022618|GO:0034613|GO:0050658|GO:0010467|GO:0017038|GO:0016070|GO:0005634|GO:0006606|GO:0005643|GO:0033365|GO:0000339|GO:0034622|GO:0051169|GO:0006396|GO:0034660|GO:0006605|GO:0006886|GO:0016071|GO:0000387|GO:0061015|GO:0006404|GO:0006913|GO:0006397|GO:0008380|GO:0034504|GO:0000375|GO:0051170|GO:0000398 transporter activity|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|cellular aromatic compound metabolic process|protein transporter activity|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|nuclear envelope|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|extracellular exosome|establishment of localization in cell|RNA localization|ribonucleoprotein complex biogenesis|cytosol|RNA binding|establishment of protein localization to organelle|protein transport|intracellular transport|ribonucleoprotein complex assembly|cellular protein localization|RNA transport|gene expression|protein import|RNA metabolic process|nucleus|protein import into nucleus|nuclear pore|protein localization to organelle|RNA cap binding|cellular macromolecular complex assembly|nuclear transport|RNA processing|ncRNA metabolic process|protein targeting|intracellular protein transport|mRNA metabolic process|spliceosomal snRNP assembly|snRNA import into nucleus|RNA import into nucleus|nucleocytoplasmic transport|mRNA processing|RNA splicing|protein localization to nucleus|RNA splicing, via transesterification reactions|nuclear import|mRNA splicing, via spliceosome K13151 snurportin-1[-] hsa03013 RNA transport - Homo sapiens (human) 15:75598083-75626469 760 737 603 390 411 292 7.89427690993591 6.95739102881759 5.64716556576932 3.62961805872378 3.50274582355472 2.84256023785717 6.83294450150761 3.32497470671189 1.03916404302769 2.2530404311443e-06 2.60403674143948e-05 UP ENSG00000255198 SNHG9 small nucleolar RNA host gene 9 [Source:HGNC Symbol;Acc:HGNC:33102] - - - - - - 16:1964959-1965509 49 50 35 13 18 9 4.64626037108892 4.30880040744433 2.99222311757118 1.10444909488315 1.40036612027732 0.799788505562821 3.98242796536814 1.10153457357443 1.85413348910943 2.26957946709109e-06 2.62213720629014e-05 UP ENSG00000104228 TRIM35 tripartite motif containing 35 [Source:HGNC Symbol;Acc:HGNC:16285] GO:0002376|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0043167|GO:0006955|GO:0043227|GO:0005622|GO:0005515|GO:0016032|GO:0051726|GO:0007049|GO:0045087|GO:0010941|GO:0006952|GO:0010942|GO:0045786|GO:0043231|GO:0043169|GO:0005737|GO:0048525|GO:0008219|GO:0050792|GO:0046872|GO:0019076|GO:0000278|GO:0007346|GO:0045930|GO:0012501|GO:0019058|GO:0043068|GO:0005634|GO:0043067|GO:1902186|GO:0043065|GO:0042981|GO:0046914|GO:0006915|GO:1902187|GO:0008270 immune system process|cell|cellular process|response to stimulus|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|ion binding|immune response|membrane-bounded organelle|intracellular|protein binding|viral process|regulation of cell cycle|cell cycle|innate immune response|regulation of cell death|defense response|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|cytoplasm|negative regulation of viral process|cell death|regulation of viral process|metal ion binding|viral release from host cell|mitotic cell cycle|regulation of mitotic cell cycle|negative regulation of mitotic cell cycle|programmed cell death|viral life cycle|positive regulation of programmed cell death|nucleus|regulation of programmed cell death|regulation of viral release from host cell|positive regulation of apoptotic process|regulation of apoptotic process|transition metal ion binding|apoptotic process|negative regulation of viral release from host cell|zinc ion binding - - - - 8:27284887-27311319 446 585 481 274 297 216 5.34903811728677 6.37641609713691 5.20116571793001 2.94435004244902 2.92257359442001 2.42785417435523 5.6422066441179 2.76492593707475 1.0290186690588 2.27405735474365e-06 2.62629432373373e-05 UP ENSG00000278974 RP11-756P10.6 - - - - - - - 4:188740507-188741281 187 167 109 68 56 36 17.0681364520276 13.8529159636935 8.96985909259023 5.56099321398796 4.19373655787011 3.07944374270898 13.2969705027704 4.27805783818902 1.63606969610222 2.28350861059844e-06 2.63618971619512e-05 UP ENSG00000280143 AP000892.6 - - - - - - - 11:117204967-117210292 1 2 2 26 16 10 0.0132870246756691 0.0241409320612353 0.0239497003367306 0.309395052490736 0.17435313404189 0.124470140917684 0.020459219024545 0.202739442483437 -3.30880380879146 2.29586566993212e-06 2.64840702125787e-05 DOWN ENSG00000183742 MACC1 metastasis associated in colon cancer 1 [Source:HGNC Symbol;Acc:HGNC:30215] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0051302|GO:0005102|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0051781|GO:0051301|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0005739|GO:0010467|GO:0009059|GO:0016070|GO:0008083|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|positive regulation of cell division|cell division|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|mitochondrion|gene expression|macromolecule biosynthetic process|RNA metabolic process|growth factor activity|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 7:20134655-20217404 168 217 297 601 633 436 1.0761358926816 1.26327763975513 1.7152567989107 3.44929620513997 3.32682748642908 2.61742111192208 1.35155677711581 3.13118160116371 -1.21208506496055 2.30478224736233e-06 2.65766586376034e-05 DOWN ENSG00000225648 SBDSP1 Shwachman-Bodian-Diamond syndrome pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:21646] - - - - - - 7:72829425-72836701 1168 1342 640 456 498 207 30.6797789300011 32.036272220105 15.1566599718666 10.7317887172432 10.7326369279565 5.09574515231983 25.9575703739909 8.85339026583984 1.55185343017265 2.31228132124942e-06 2.6652836511421e-05 UP ENSG00000137501 SYTL2 synaptotagmin like 2 [Source:HGNC Symbol;Acc:HGNC:15585] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0019898|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0072341|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0019222|GO:0006810|GO:0005102|GO:0043168|GO:0032940|GO:0005543|GO:0031982|GO:0030276|GO:0043231|GO:0043169|GO:0030133|GO:0019899|GO:0005737|GO:0070255|GO:0043177|GO:0022406|GO:0070257|GO:0045184|GO:0019897|GO:0000149|GO:0008104|GO:0001786|GO:0044092|GO:0061024|GO:0051649|GO:0051047|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0010256|GO:0050878|GO:0016192|GO:0032268|GO:0048278|GO:0046872|GO:0043412|GO:0007589|GO:0031410|GO:0035091|GO:0015031|GO:0007009|GO:0016023|GO:0006887|GO:0036211|GO:0032269|GO:0070382|GO:0046907|GO:0019902|GO:0042043|GO:0051046|GO:0072657|GO:0070254|GO:0051346|GO:0031988|GO:0034613|GO:0005544|GO:0006796|GO:0044267|GO:0031406|GO:0051174|GO:0046903|GO:0051246|GO:0051020|GO:0019905|GO:0010923|GO:0016311|GO:0006904|GO:0072659|GO:0005509|GO:0006886|GO:1901981|GO:0031267|GO:0016597|GO:0006464|GO:1990778|GO:0010921|GO:0006470|GO:0035304|GO:0017016|GO:1902936|GO:0042470|GO:0035305|GO:0035303|GO:0035308|GO:0017137|GO:0005546 cell|membrane|cellular process|metabolic process|binding|small molecule binding|extrinsic component of membrane|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|modified amino acid binding|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|intracellular|protein binding|plasma membrane|endomembrane system|regulation of metabolic process|transport|receptor binding|anion binding|secretion by cell|phospholipid binding|vesicle|clathrin binding|intracellular membrane-bounded organelle|cation binding|transport vesicle|enzyme binding|cytoplasm|regulation of mucus secretion|organic acid binding|membrane docking|positive regulation of mucus secretion|establishment of protein localization|extrinsic component of plasma membrane|SNARE binding|protein localization|phosphatidylserine binding|negative regulation of molecular function|membrane organization|establishment of localization in cell|positive regulation of secretion|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endomembrane system organization|regulation of body fluid levels|vesicle-mediated transport|regulation of cellular protein metabolic process|vesicle docking|metal ion binding|macromolecule modification|body fluid secretion|cytoplasmic vesicle|phosphatidylinositol binding|protein transport|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|exocytosis|protein modification process|negative regulation of cellular protein metabolic process|exocytic vesicle|intracellular transport|phosphatase binding|neurexin family protein binding|regulation of secretion|protein localization to membrane|mucus secretion|negative regulation of hydrolase activity|membrane-bounded vesicle|cellular protein localization|calcium-dependent phospholipid binding|phosphate-containing compound metabolic process|cellular protein metabolic process|carboxylic acid binding|regulation of phosphorus metabolic process|secretion|regulation of protein metabolic process|GTPase binding|syntaxin binding|negative regulation of phosphatase activity|dephosphorylation|vesicle docking involved in exocytosis|protein localization to plasma membrane|calcium ion binding|intracellular protein transport|phosphatidylinositol phosphate binding|small GTPase binding|amino acid binding|cellular protein modification process|protein localization to cell periphery|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|Ras GTPase binding|phosphatidylinositol bisphosphate binding|melanosome|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation|Rab GTPase binding|phosphatidylinositol-4,5-bisphosphate binding - - - - 11:85694224-85811159 687 729 1021 1679 1592 2433 1.5910242190979 1.53436139633366 2.1318651455482 3.48392132550114 3.02503886422606 5.28069201189607 1.75241692032659 3.92988406720776 -1.16514070349131 2.3155197623103e-06 2.66798637529956e-05 DOWN ENSG00000160908 ZNF394 zinc finger protein 394 [Source:HGNC Symbol;Acc:HGNC:18832] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 7:99486519-99500324 619 639 458 295 318 244 5.8836463885858 5.51996996145972 3.92496823200802 2.51232765331924 2.47999781604679 2.17357791694771 5.10952819401785 2.38863446210458 1.09700398912501 2.35150208715963e-06 2.70735608600322e-05 UP ENSG00000132326 PER2 period circadian clock 2 [Source:HGNC Symbol;Acc:HGNC:8846] GO:0032502|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0042752|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0000989|GO:0016043|GO:0043227|GO:0042754|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:0044262|GO:0051726|GO:0042127|GO:0007049|GO:0044255|GO:0032182|GO:0050804|GO:0045595|GO:0003712|GO:0006725|GO:0048468|GO:0006810|GO:1901360|GO:0006082|GO:0007275|GO:0016570|GO:0003676|GO:0097167|GO:0034641|GO:0015980|GO:0044281|GO:0032940|GO:0046483|GO:0032922|GO:0051098|GO:0043231|GO:0005737|GO:0007267|GO:0002931|GO:0032880|GO:0005975|GO:0045184|GO:0009890|GO:0046883|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0044092|GO:0006629|GO:0051649|GO:0001505|GO:0008285|GO:0006091|GO:0010817|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0003013|GO:0006996|GO:0055114|GO:0003713|GO:0098657|GO:0006836|GO:0051276|GO:0005730|GO:0032268|GO:0003677|GO:0005976|GO:0070345|GO:0035150|GO:0010468|GO:0034645|GO:0006518|GO:0051101|GO:0090276|GO:0051100|GO:0043412|GO:0010629|GO:0043130|GO:0051252|GO:0006631|GO:0006325|GO:0051223|GO:0015031|GO:0036211|GO:0032269|GO:0070201|GO:0042886|GO:0006811|GO:0051046|GO:0033692|GO:0031981|GO:0009914|GO:0005977|GO:0009306|GO:0005996|GO:0048471|GO:0005654|GO:0006089|GO:0043269|GO:0006112|GO:0043603|GO:0044267|GO:0010467|GO:0007399|GO:0046903|GO:0051246|GO:0009059|GO:0030154|GO:0016070|GO:0008015|GO:0001504|GO:0016575|GO:0005634|GO:0016051|GO:0051580|GO:0051960|GO:0015837|GO:0005978|GO:0050796|GO:0002790|GO:0019318|GO:0000975|GO:0030073|GO:0043043|GO:0006820|GO:0015711|GO:0045444|GO:2000677|GO:0045892|GO:0000271|GO:0032774|GO:0043565|GO:2001141|GO:0050708|GO:0015833|GO:0010608|GO:1902679|GO:0019229|GO:0003690|GO:0046942|GO:0006412|GO:0006417|GO:0044070|GO:0019752|GO:0016568|GO:0006865|GO:0070932|GO:0022008|GO:0051946|GO:0006464|GO:0019249|GO:0050767|GO:0046879|GO:0006351|GO:0006355|GO:0050880|GO:0043392|GO:0006366|GO:0030072|GO:0019319|GO:1903507|GO:0006357|GO:0002036|GO:0048699|GO:0006835|GO:1903506|GO:0006006|GO:0044212|GO:0015807|GO:0042310|GO:0050872|GO:0032787|GO:0000122|GO:2000678|GO:1990123|GO:0007268|GO:0051935|GO:0032446|GO:0015813|GO:0000976|GO:0031396|GO:0031397|GO:0006094|GO:0006476|GO:0051938|GO:0016567 developmental process|signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|regulation of circadian rhythm|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|negative regulation of circadian rhythm|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|cellular carbohydrate metabolic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular lipid metabolic process|ubiquitin-like protein binding|modulation of synaptic transmission|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|transport|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|histone modification|nucleic acid binding|circadian regulation of translation|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|heterocycle metabolic process|circadian regulation of gene expression|regulation of binding|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|response to ischemia|regulation of protein localization|carbohydrate metabolic process|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|negative regulation of molecular function|lipid metabolic process|establishment of localization in cell|regulation of neurotransmitter levels|negative regulation of cell proliferation|generation of precursor metabolites and energy|regulation of hormone levels|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|organelle organization|oxidation-reduction process|transcription coactivator activity|import into cell|neurotransmitter transport|chromosome organization|nucleolus|regulation of cellular protein metabolic process|DNA binding|polysaccharide metabolic process|negative regulation of fat cell proliferation|regulation of tube size|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|regulation of DNA binding|regulation of peptide hormone secretion|negative regulation of binding|macromolecule modification|negative regulation of gene expression|ubiquitin binding|regulation of RNA metabolic process|fatty acid metabolic process|chromatin organization|regulation of protein transport|protein transport|protein modification process|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|amide transport|ion transport|regulation of secretion|cellular polysaccharide biosynthetic process|nuclear lumen|hormone transport|glycogen metabolic process|protein secretion|monosaccharide metabolic process|perinuclear region of cytoplasm|nucleoplasm|lactate metabolic process|regulation of ion transport|energy reserve metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|nervous system development|secretion|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|blood circulation|neurotransmitter uptake|histone deacetylation|nucleus|carbohydrate biosynthetic process|regulation of neurotransmitter uptake|regulation of nervous system development|amine transport|glycogen biosynthetic process|regulation of insulin secretion|peptide secretion|hexose metabolic process|regulatory region DNA binding|insulin secretion|peptide biosynthetic process|anion transport|organic anion transport|fat cell differentiation|regulation of transcription regulatory region DNA binding|negative regulation of transcription, DNA-templated|polysaccharide biosynthetic process|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of protein secretion|peptide transport|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|regulation of vasoconstriction|double-stranded DNA binding|carboxylic acid transport|translation|regulation of translation|regulation of anion transport|carboxylic acid metabolic process|chromatin modification|amino acid transport|histone H3 deacetylation|neurogenesis|regulation of glutamate uptake involved in transmission of nerve impulse|cellular protein modification process|lactate biosynthetic process|regulation of neurogenesis|hormone secretion|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of blood vessel size|negative regulation of DNA binding|transcription from RNA polymerase II promoter|peptide hormone secretion|hexose biosynthetic process|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of L-glutamate transport|generation of neurons|dicarboxylic acid transport|regulation of nucleic acid-templated transcription|glucose metabolic process|transcription regulatory region DNA binding|L-amino acid transport|vasoconstriction|white fat cell differentiation|monocarboxylic acid metabolic process|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|L-glutamate import into cell|synaptic transmission|glutamate reuptake|protein modification by small protein conjugation|L-glutamate transport|transcription regulatory region sequence-specific DNA binding|regulation of protein ubiquitination|negative regulation of protein ubiquitination|gluconeogenesis|protein deacetylation|L-glutamate import|protein ubiquitination K02633 period circadian protein[-] hsa05168|hsa05202|hsa04713|hsa04710 Herpes simplex infection - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Circadian rhythm - Homo sapiens (human) 2:238244038-238290102 471 523 421 239 267 236 4.56210670695397 4.60390105600592 3.6765519694512 2.07415348301289 2.1218948117068 2.14232649296902 4.28085324413703 2.11279159589624 1.01874791004339 2.39222486956249e-06 2.75105859999686e-05 UP ENSG00000178732 GP5 glycoprotein V (platelet) [Source:HGNC Symbol;Acc:HGNC:4443] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0006950|GO:0071704|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0050817|GO:0048468|GO:0007275|GO:0031982|GO:0005887|GO:0009611|GO:0001775|GO:0031226|GO:0007597|GO:0072378|GO:0070062|GO:0030030|GO:0048869|GO:0016021|GO:0019538|GO:0050878|GO:0000902|GO:0031175|GO:0030168|GO:0007596|GO:0000904|GO:0042060|GO:0007599|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0048666|GO:0030182|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699 developmental process|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|response to stress|organic substance metabolic process|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|coagulation|cell development|multicellular organism development|vesicle|integral component of plasma membrane|response to wounding|cell activation|intrinsic component of plasma membrane|blood coagulation, intrinsic pathway|blood coagulation, fibrin clot formation|extracellular exosome|cell projection organization|cellular developmental process|integral component of membrane|protein metabolic process|regulation of body fluid levels|cell morphogenesis|neuron projection development|platelet activation|blood coagulation|cell morphogenesis involved in differentiation|wound healing|hemostasis|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|neuron development|neuron differentiation|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons K06260 platelet glycoprotein V[-] hsa04611|hsa04640|hsa04512 Platelet activation - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 3:194394821-194398354 23 18 3 0 1 0 0.460376723042202 0.327439569163342 0.0541315172080565 0 0.0164298889599186 0 0.280649269804533 0.0054766296533062 5.67933617131532 2.39773901623915e-06 2.75633810515223e-05 UP ENSG00000180739 S1PR5 sphingosine-1-phosphate receptor 5 [Source:HGNC Symbol;Acc:HGNC:14299] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0050793|GO:0005886|GO:0048856|GO:0045595|GO:0048468|GO:0007275|GO:0004888|GO:0007154|GO:0007165|GO:0048869|GO:0016021|GO:0007186|GO:0007399|GO:0030154|GO:0004930|GO:0051960|GO:0030182|GO:0045125|GO:0003376|GO:0022008|GO:0050767|GO:0048699|GO:0038036|GO:0045664 developmental process|signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|regulation of developmental process|plasma membrane|anatomical structure development|regulation of cell differentiation|cell development|multicellular organism development|transmembrane signaling receptor activity|cell communication|signal transduction|cellular developmental process|integral component of membrane|G-protein coupled receptor signaling pathway|nervous system development|cell differentiation|G-protein coupled receptor activity|regulation of nervous system development|neuron differentiation|bioactive lipid receptor activity|sphingosine-1-phosphate signaling pathway|neurogenesis|regulation of neurogenesis|generation of neurons|sphingosine-1-phosphate receptor activity|regulation of neuron differentiation K04295 sphingosine 1-phosphate receptor 5[-] hsa04080|hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human) 19:10512742-10517931 284 326 319 170 165 144 2.95647675210647 3.08427674433799 2.99406887038978 1.58563064516404 1.40931654682029 1.40490744946994 3.01160745561141 1.46661821381809 1.03804037457615 2.41948403678787e-06 2.78026468184238e-05 UP ENSG00000119042 SATB2 SATB homeobox 2 [Source:HGNC Symbol;Acc:HGNC:21637] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0030900|GO:0031325|GO:0046483|GO:0007420|GO:0043231|GO:0005737|GO:0007389|GO:0060322|GO:0006928|GO:0009887|GO:0005667|GO:0048598|GO:0048568|GO:0009890|GO:0003682|GO:0006139|GO:0016477|GO:0001503|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0060021|GO:0006996|GO:0051276|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0051216|GO:0007417|GO:0010629|GO:0051252|GO:0009880|GO:0006325|GO:0009790|GO:0010628|GO:0001764|GO:0001649|GO:0031981|GO:0005654|GO:0016363|GO:0021872|GO:0010467|GO:0000118|GO:0048562|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0034399|GO:0001501|GO:0061448|GO:0016070|GO:0010557|GO:0005634|GO:0002076|GO:0045165|GO:0030182|GO:0021953|GO:0048706|GO:0045893|GO:0009792|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0048663|GO:0016568|GO:0048704|GO:0021879|GO:0022008|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0021877|GO:0006357|GO:0048699|GO:1903506|GO:0043009|GO:0006338|GO:0000122|GO:0021902 locomotion|developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|head development|movement of cell or subcellular component|organ morphogenesis|transcription factor complex|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|cell migration|ossification|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|palate development|organelle organization|chromosome organization|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|central nervous system development|negative regulation of gene expression|regulation of RNA metabolic process|embryonic pattern specification|chromatin organization|embryo development|positive regulation of gene expression|neuron migration|osteoblast differentiation|nuclear lumen|nucleoplasm|nuclear matrix|forebrain generation of neurons|gene expression|histone deacetylase complex|embryonic organ morphogenesis|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|nuclear periphery|skeletal system development|connective tissue development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|osteoblast development|cell fate commitment|neuron differentiation|central nervous system neuron differentiation|embryonic skeletal system development|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|neuron fate commitment|chromatin modification|embryonic skeletal system morphogenesis|forebrain neuron differentiation|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|forebrain neuron fate commitment|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|chordate embryonic development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|commitment of neuronal cell to specific neuron type in forebrain - - - - 2:199269500-199471266 32 36 58 95 143 177 0.127076098144 0.129924374044041 0.207660712258218 0.33800912726139 0.465920284114329 0.658735630360666 0.154887061482086 0.487555013912128 -1.65434838306524 2.42252858882671e-06 2.78269213123635e-05 DOWN ENSG00000139372 TDG thymine DNA glycosylase [Source:HGNC Symbol;Acc:HGNC:11700] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0042802|GO:0006281|GO:0032182|GO:0003712|GO:0006725|GO:1901360|GO:0080111|GO:0007275|GO:0003676|GO:0016798|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0033554|GO:0051098|GO:0043231|GO:0019899|GO:0001076|GO:0046983|GO:0070988|GO:0009890|GO:0006139|GO:0055086|GO:0044092|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0055114|GO:0051276|GO:0003677|GO:0035511|GO:0009262|GO:0010468|GO:0034645|GO:0070989|GO:0051100|GO:0043412|GO:0001104|GO:0010629|GO:0032183|GO:0051252|GO:0006325|GO:0006284|GO:0009790|GO:0036211|GO:0031981|GO:0006298|GO:0005654|GO:0006259|GO:0019900|GO:0006796|GO:0044267|GO:0010467|GO:0019439|GO:0016799|GO:0009059|GO:0016070|GO:0046434|GO:0005634|GO:0042803|GO:0006974|GO:0043393|GO:0006285|GO:0043566|GO:0045892|GO:0009117|GO:0032774|GO:0006220|GO:0046386|GO:2001141|GO:1902679|GO:0016604|GO:0006304|GO:0003690|GO:0035562|GO:0040029|GO:0003684|GO:0019104|GO:0016568|GO:0009166|GO:0009264|GO:0019901|GO:0006464|GO:0032091|GO:0006351|GO:0006355|GO:0009223|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0005080|GO:0018193|GO:0016605|GO:0043687|GO:0000122|GO:0030983|GO:0045008|GO:0032446|GO:0004844|GO:0008263|GO:0018205|GO:0016925 developmental process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|identical protein binding|DNA repair|ubiquitin-like protein binding|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|DNA demethylation|multicellular organism development|nucleic acid binding|hydrolase activity, acting on glycosyl bonds|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|regulation of binding|intracellular membrane-bounded organelle|enzyme binding|transcription factor activity, RNA polymerase II transcription factor binding|protein dimerization activity|demethylation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|negative regulation of molecular function|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|chromosome organization|DNA binding|oxidative DNA demethylation|deoxyribonucleotide metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|oxidative demethylation|negative regulation of binding|macromolecule modification|RNA polymerase II transcription cofactor activity|negative regulation of gene expression|SUMO binding|regulation of RNA metabolic process|chromatin organization|base-excision repair|embryo development|protein modification process|nuclear lumen|mismatch repair|nucleoplasm|DNA metabolic process|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|aromatic compound catabolic process|hydrolase activity, hydrolyzing N-glycosyl compounds|macromolecule biosynthetic process|RNA metabolic process|organophosphate catabolic process|nucleus|protein homodimerization activity|cellular response to DNA damage stimulus|regulation of protein binding|base-excision repair, AP site formation|structure-specific DNA binding|negative regulation of transcription, DNA-templated|nucleotide metabolic process|RNA biosynthetic process|pyrimidine nucleotide metabolic process|deoxyribose phosphate catabolic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|nuclear body|DNA modification|double-stranded DNA binding|negative regulation of chromatin binding|regulation of gene expression, epigenetic|damaged DNA binding|DNA N-glycosylase activity|chromatin modification|nucleotide catabolic process|deoxyribonucleotide catabolic process|protein kinase binding|cellular protein modification process|negative regulation of protein binding|transcription, DNA-templated|regulation of transcription, DNA-templated|pyrimidine deoxyribonucleotide catabolic process|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|protein kinase C binding|peptidyl-amino acid modification|PML body|post-translational protein modification|negative regulation of transcription from RNA polymerase II promoter|mismatched DNA binding|depyrimidination|protein modification by small protein conjugation|uracil DNA N-glycosylase activity|pyrimidine-specific mismatch base pair DNA N-glycosylase activity|peptidyl-lysine modification|protein sumoylation K03649 TDG/mug DNA glycosylase family protein [EC:3.2.2.-][-] hsa03410 Base excision repair - Homo sapiens (human) 12:103965804-103988874 826 1189 622 468 425 310 6.84256232510706 8.95159778030065 4.6456197583616 3.47361671490876 2.88865622631397 2.40674437133827 6.81325995458977 2.92300577085367 1.22089257527231 2.42348215140167e-06 2.78271677492097e-05 UP ENSG00000187742 SECISBP2 SECIS binding protein 2 [Source:HGNC Symbol;Acc:HGNC:30972] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0021544|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0043021|GO:0034641|GO:0030900|GO:0046483|GO:0007420|GO:0043231|GO:0005737|GO:0030529|GO:0060322|GO:0006139|GO:0021756|GO:0048869|GO:0021537|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0007417|GO:0051252|GO:0044265|GO:0031981|GO:0005654|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0007399|GO:0019439|GO:0051246|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0048666|GO:0030182|GO:0006401|GO:0043043|GO:0010608|GO:0006412|GO:0016071|GO:0006417|GO:0044822|GO:0022008|GO:0006414|GO:0048699|GO:0003729|GO:0006402|GO:0000956|GO:2000623|GO:0003730|GO:0001514|GO:0035368|GO:0000184 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|subpallium development|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|ribonucleoprotein complex binding|cellular nitrogen compound metabolic process|forebrain development|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|head development|nucleobase-containing compound metabolic process|striatum development|cellular developmental process|telencephalon development|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|central nervous system development|regulation of RNA metabolic process|cellular macromolecule catabolic process|nuclear lumen|nucleoplasm|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|nervous system development|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|neuron development|neuron differentiation|RNA catabolic process|peptide biosynthetic process|posttranscriptional regulation of gene expression|translation|mRNA metabolic process|regulation of translation|poly(A) RNA binding|neurogenesis|translational elongation|generation of neurons|mRNA binding|mRNA catabolic process|nuclear-transcribed mRNA catabolic process|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|mRNA 3'-UTR binding|selenocysteine incorporation|selenocysteine insertion sequence binding|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay - - - - 9:89318506-89359662 281 337 496 762 820 915 1.46004302271518 1.59136559609992 2.32357226458976 3.54742226613096 3.49575963432104 4.45563925588772 1.79166029446829 3.83294038544657 -1.09715443684645 2.42860296388061e-06 2.78752452455562e-05 DOWN ENSG00000256671 LIMS3L LIM and senescent cell antigen-like domains 3-like [Source:HGNC Symbol;Acc:HGNC:39941] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|protein binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 2:110446640-110473075 31 35 64 119 160 120 0.444704896129885 0.456314337340357 0.827755390606812 1.52952688024157 1.88320949917258 1.61331914009974 0.576258208025685 1.67535183983796 -1.5396768070263 2.43031456074337e-06 2.7884170213848e-05 DOWN ENSG00000204262 COL5A2 collagen, type V, alpha 2 [Source:HGNC Symbol;Acc:HGNC:2210] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0005201|GO:0048523|GO:0050794|GO:0043229|GO:0005578|GO:0071704|GO:0009056|GO:0043167|GO:0009653|GO:0016043|GO:0005583|GO:0043227|GO:0009605|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0006935|GO:0045595|GO:0009888|GO:0048468|GO:0007275|GO:0045596|GO:0048513|GO:0043062|GO:0043231|GO:0046332|GO:0043169|GO:0010243|GO:0005737|GO:0045992|GO:0007423|GO:0006928|GO:0009887|GO:0048598|GO:0044236|GO:0001704|GO:0005783|GO:0001503|GO:0005588|GO:0030030|GO:0048869|GO:0005581|GO:0010033|GO:1903225|GO:0000902|GO:0031175|GO:0030574|GO:0044259|GO:0046872|GO:0001654|GO:0022617|GO:0007492|GO:0000904|GO:0009790|GO:0071417|GO:0043200|GO:0007369|GO:0001706|GO:0043588|GO:0032990|GO:0005788|GO:0007399|GO:0071310|GO:0097485|GO:0030198|GO:0010470|GO:0030154|GO:0001501|GO:0048858|GO:0045995|GO:0048666|GO:0030182|GO:0007411|GO:0035987|GO:0061564|GO:0030199|GO:0022008|GO:0048667|GO:0048812|GO:0071230|GO:0048592|GO:0032963|GO:0007409|GO:0048699 locomotion|developmental process|extracellular matrix|macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|extracellular matrix structural constituent|negative regulation of cellular process|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|organic substance metabolic process|catabolic process|ion binding|anatomical structure morphogenesis|cellular component organization|fibrillar collagen trimer|membrane-bounded organelle|response to external stimulus|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|chemotaxis|regulation of cell differentiation|tissue development|cell development|multicellular organism development|negative regulation of cell differentiation|animal organ development|extracellular structure organization|intracellular membrane-bounded organelle|SMAD binding|cation binding|response to organonitrogen compound|cytoplasm|negative regulation of embryonic development|sensory organ development|movement of cell or subcellular component|organ morphogenesis|embryonic morphogenesis|multicellular organism metabolic process|formation of primary germ layer|endoplasmic reticulum|ossification|collagen type V trimer|cell projection organization|cellular developmental process|collagen trimer|response to organic substance|negative regulation of endodermal cell differentiation|cell morphogenesis|neuron projection development|collagen catabolic process|multicellular organismal macromolecule metabolic process|metal ion binding|eye development|extracellular matrix disassembly|endoderm development|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|response to amino acid|gastrulation|endoderm formation|skin development|cell part morphogenesis|endoplasmic reticulum lumen|nervous system development|cellular response to organic substance|neuron projection guidance|extracellular matrix organization|regulation of gastrulation|cell differentiation|skeletal system development|cell projection morphogenesis|regulation of embryonic development|neuron development|neuron differentiation|axon guidance|endodermal cell differentiation|axon development|collagen fibril organization|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|cellular response to amino acid stimulus|eye morphogenesis|collagen metabolic process|axonogenesis|generation of neurons K19721 collagen, type V/XI/XXIV/XXVII, alpha[-] hsa04974 Protein digestion and absorption - Homo sapiens (human) 2:189031896-189179879 9 6 7 32 43 29 0.0662264846570201 0.0401252275537727 0.0464384676791975 0.210977131510108 0.259608288827361 0.199989406658174 0.0509300599633301 0.223524942331881 -2.13384650453181 2.43689900947576e-06 2.79489754240835e-05 DOWN ENSG00000241839 PLEKHO2 pleckstrin homology domain containing O2 [Source:HGNC Symbol;Acc:HGNC:30026] - - - - hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) 15:64841883-64868007 237 279 350 127 147 157 2.40594380304642 2.57407975096416 3.20346117446413 1.15514921772586 1.22440195320279 1.49371438613079 2.7278282428249 1.29108851901981 1.07916489077614 2.45137160044471e-06 2.81041658063274e-05 UP ENSG00000158711 ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) [Source:HGNC Symbol;Acc:HGNC:3326] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0016570|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0009890|GO:0003682|GO:0006139|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0036211|GO:0031981|GO:0005654|GO:0044267|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0016575|GO:0005634|GO:0000975|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0016568|GO:0070932|GO:0006464|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0001047|GO:0006476 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|histone modification|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|protein modification process|nuclear lumen|nucleoplasm|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|histone deacetylation|nucleus|regulatory region DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|chromatin modification|histone H3 deacetylation|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|core promoter binding|protein deacetylation K04376 ETS domain-containing protein Elk-4[-] hsa05166|hsa04010|hsa05202 HTLV-I infection - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human) 1:205597556-205631962 541 675 864 1324 1506 1674 2.76447399191672 3.13472219374628 3.9805558917671 6.06179496136092 6.31405764549426 8.01678105026942 3.2932506924767 6.79754455237487 -1.04550136343015 2.46950185693792e-06 2.82902948722275e-05 DOWN ENSG00000128422 KRT17 keratin 17, type I [Source:HGNC Symbol;Acc:HGNC:6427] GO:0032502|GO:0040007|GO:0004871|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0005200|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0038023|GO:0009653|GO:0016043|GO:0045927|GO:0043227|GO:0071944|GO:0040008|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0009888|GO:0045684|GO:0045103|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0030307|GO:0031069|GO:0031982|GO:0031325|GO:0051128|GO:0005882|GO:0004888|GO:0001942|GO:0005737|GO:0048729|GO:0031424|GO:0007154|GO:0007165|GO:0070062|GO:0048869|GO:0042634|GO:0044249|GO:0019538|GO:0001558|GO:0042635|GO:0031323|GO:0006996|GO:0032268|GO:0045682|GO:0010468|GO:0034645|GO:0006518|GO:0002009|GO:0007010|GO:0022405|GO:0010628|GO:0051798|GO:0042287|GO:0051247|GO:0043588|GO:0032270|GO:0060429|GO:0043603|GO:0044267|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0032395|GO:0051797|GO:0045104|GO:0005856|GO:0010557|GO:0042633|GO:0045109|GO:0043043|GO:0030855|GO:0030216|GO:0045727|GO:0010608|GO:0008544|GO:0006412|GO:0006417|GO:0045111|GO:0048730|GO:0042289|GO:0098773|GO:0009913 developmental process|growth|signal transducer activity|structural molecule activity|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|structural constituent of cytoskeleton|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|signaling receptor activity|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|membrane-bounded organelle|cell periphery|regulation of growth|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|tissue development|positive regulation of epidermis development|intermediate filament-based process|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cell growth|hair follicle morphogenesis|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|intermediate filament|transmembrane signaling receptor activity|hair follicle development|cytoplasm|tissue morphogenesis|keratinization|cell communication|signal transduction|extracellular exosome|cellular developmental process|regulation of hair cycle|cellular biosynthetic process|protein metabolic process|regulation of cell growth|positive regulation of hair cycle|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|regulation of epidermis development|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|morphogenesis of an epithelium|cytoskeleton organization|hair cycle process|positive regulation of gene expression|positive regulation of hair follicle development|MHC protein binding|positive regulation of protein metabolic process|skin development|positive regulation of cellular protein metabolic process|epithelium development|cellular amide metabolic process|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|MHC class II receptor activity|regulation of hair follicle development|intermediate filament cytoskeleton organization|cytoskeleton|positive regulation of macromolecule biosynthetic process|hair cycle|intermediate filament organization|peptide biosynthetic process|epithelial cell differentiation|keratinocyte differentiation|positive regulation of translation|posttranscriptional regulation of gene expression|epidermis development|translation|regulation of translation|intermediate filament cytoskeleton|epidermis morphogenesis|MHC class II protein binding|skin epidermis development|epidermal cell differentiation - - - - 17:41619437-41624842 17 22 39 6 7 3 0.216862705246755 0.255062334668986 0.448568197239848 0.0685816259046002 0.07326748945783 0.0358624411421378 0.306831079051863 0.0592371855015227 2.37286961992119 2.50208763313972e-06 2.86525984655746e-05 UP ENSG00000255455 RP11-890B15.3 - - - - - - - 11:130866254-130870247 11 9 17 54 38 60 0.194817807437222 0.144871342856659 0.27145556078299 0.85689479327616 0.552196471362659 0.995903440139183 0.20371490369229 0.801664901592667 -1.97644778060003 2.50932281575972e-06 2.87244337966605e-05 DOWN ENSG00000197429 IPP intracisternal A particle-promoted polypeptide [Source:HGNC Symbol;Acc:HGNC:6108] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0005737|GO:0008092|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0004842|GO:0031461|GO:0003779|GO:0036211|GO:1990234|GO:0044267|GO:0005856|GO:0015629|GO:0006464|GO:0031463|GO:0032446|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|protein complex|transferase activity|cytoplasm|cytoskeletal protein binding|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|actin binding|protein modification process|transferase complex|cellular protein metabolic process|cytoskeleton|actin cytoskeleton|cellular protein modification process|Cul3-RING ubiquitin ligase complex|protein modification by small protein conjugation|protein ubiquitination - - - - 1:45694324-45750650 218 229 289 544 591 507 3.55970581559046 3.3983893353566 4.25469907996241 7.95891728769651 7.91794703563581 7.75879591678836 3.73759807696982 7.87855341337356 -1.07581932271555 2.54941956178487e-06 2.91610619147607e-05 DOWN ENSG00000065613 SLK STE20 like kinase [Source:HGNC Symbol;Acc:HGNC:11088] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0042802|GO:0051726|GO:0007049|GO:0010941|GO:0043168|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0033554|GO:0005737|GO:0046983|GO:0043085|GO:0007154|GO:0007165|GO:0070062|GO:0008219|GO:0050790|GO:0000166|GO:0019538|GO:0023014|GO:0031323|GO:0032268|GO:0035639|GO:0043412|GO:0001883|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0031098|GO:0007346|GO:0051247|GO:0016301|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:0016773|GO:0042803|GO:0043067|GO:0031401|GO:0005524|GO:0030554|GO:0016310|GO:0042981|GO:0004672|GO:0006464|GO:0043549|GO:0006915|GO:0033674|GO:0045859|GO:0045860|GO:0006468|GO:0042325|GO:0001932|GO:0004674|GO:0001934|GO:0042327|GO:0046777|GO:0032147 signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|transferase activity|regulation of metabolic process|identical protein binding|regulation of cell cycle|cell cycle|regulation of cell death|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|cellular response to stress|cytoplasm|protein dimerization activity|positive regulation of catalytic activity|cell communication|signal transduction|extracellular exosome|cell death|regulation of catalytic activity|nucleotide binding|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|regulation of cellular protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|positive regulation of protein metabolic process|kinase activity|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|phosphotransferase activity, alcohol group as acceptor|protein homodimerization activity|regulation of programmed cell death|positive regulation of protein modification process|ATP binding|adenyl nucleotide binding|phosphorylation|regulation of apoptotic process|protein kinase activity|cellular protein modification process|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|positive regulation of phosphorylation|protein autophosphorylation|activation of protein kinase activity K08836 STE20-like kinase[2.7.11.1] hsa04114 Oocyte meiosis - Homo sapiens (human) 10:103967201-104029233 1096 1530 1801 2959 3347 3037 9.3881766871433 11.9108372341496 13.9090943744659 22.7098119665461 23.523099251431 24.3806156727445 11.7360360985863 23.5378422969072 -1.00403686157089 2.57445203425431e-06 2.94248434267336e-05 DOWN ENSG00000241316 SUCLG2-AS1 SUCLG2 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:49643] - - - - - - 3:67654697-67947713 3 3 5 23 22 22 0.0575627391697705 0.0523168784635417 0.086481390237781 0.395369555424783 0.346316223139505 0.395578505169787 0.0654536692903644 0.379088094578025 -2.53398717267092 2.58228741043145e-06 2.95031030811407e-05 DOWN ENSG00000163521 GLB1L galactosidase beta 1 like [Source:HGNC Symbol;Acc:HGNC:28129] GO:0005576|GO:0008152|GO:0003824|GO:0071704|GO:0016787|GO:0016798|GO:0005975|GO:0004553|GO:0004565 extracellular region|metabolic process|catalytic activity|organic substance metabolic process|hydrolase activity|hydrolase activity, acting on glycosyl bonds|carbohydrate metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|beta-galactosidase activity - - - - 2:219236606-219245478 24 31 31 83 89 85 0.200907901976906 0.235850507586867 0.233974702688905 0.622538517258836 0.611292147189101 0.666863139007107 0.223577704084226 0.633564601151681 -1.50271540568378 2.60383928781854e-06 2.97074854583335e-05 DOWN ENSG00000164430 MB21D1 Mab-21 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21367] GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051707|GO:0009607|GO:0009605|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0016740|GO:0045087|GO:0006725|GO:1901360|GO:0050688|GO:0003676|GO:0034641|GO:0043168|GO:0044281|GO:0006952|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0098542|GO:0001817|GO:0043169|GO:0005737|GO:0002218|GO:0001816|GO:0009615|GO:0001819|GO:0006139|GO:0050776|GO:0055086|GO:0050778|GO:0051607|GO:0000166|GO:0044249|GO:0010033|GO:0005829|GO:0003677|GO:0032479|GO:0046872|GO:0035639|GO:0001883|GO:0032481|GO:0043331|GO:0032549|GO:0032606|GO:0014070|GO:0006796|GO:0071310|GO:0017076|GO:0016779|GO:0045089|GO:0045088|GO:0050691|GO:0032561|GO:0009117|GO:0005524|GO:0071359|GO:0030554|GO:0061501|GO:0071407|GO:0002230|GO:0005525|GO:0043330|GO:0009165|GO:0019001|GO:0071360|GO:0009187|GO:0009190 immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|response to other organism|response to biotic stimulus|response to external stimulus|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|transferase activity|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of defense response to virus|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|defense response to other organism|regulation of cytokine production|cation binding|cytoplasm|activation of innate immune response|cytokine production|response to virus|positive regulation of cytokine production|nucleobase-containing compound metabolic process|regulation of immune response|nucleobase-containing small molecule metabolic process|positive regulation of immune response|defense response to virus|nucleotide binding|cellular biosynthetic process|response to organic substance|cytosol|DNA binding|regulation of type I interferon production|metal ion binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|positive regulation of type I interferon production|response to dsRNA|ribonucleoside binding|type I interferon production|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular response to organic substance|purine nucleotide binding|nucleotidyltransferase activity|positive regulation of innate immune response|regulation of innate immune response|regulation of defense response to virus by host|guanyl ribonucleotide binding|nucleotide metabolic process|ATP binding|cellular response to dsRNA|adenyl nucleotide binding|cyclic-GMP-AMP synthase activity|cellular response to organic cyclic compound|positive regulation of defense response to virus by host|GTP binding|response to exogenous dsRNA|nucleotide biosynthetic process|guanyl nucleotide binding|cellular response to exogenous dsRNA|cyclic nucleotide metabolic process|cyclic nucleotide biosynthetic process K17834 cyclic GMP-AMP synthase[2.7.7.86] hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human) 6:73413515-73452276 988 1162 795 535 560 296 12.9422235146821 13.8336975397241 9.38930550823877 6.27919149554551 6.01877781521194 3.63389791075345 12.0550755208817 5.3106224071703 1.18268782844031 2.60415654332614e-06 2.97074854583335e-05 UP ENSG00000198042 MAK16 MAK16 homolog [Source:HGNC Symbol;Acc:HGNC:13703] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 8:33484750-33501260 1003 1097 734 468 589 348 12.7308529614175 12.6544521181972 8.39976470396921 5.32230632130018 6.13394549157627 4.13966096863671 11.2616899278613 5.19863759383772 1.11521784327989 2.60336594182169e-06 2.97074854583335e-05 UP ENSG00000197467 COL13A1 collagen, type XIII, alpha 1 [Source:HGNC Symbol;Acc:HGNC:2190] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0005488|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0016337|GO:0008201|GO:0098797|GO:0007275|GO:0048513|GO:0043168|GO:0043062|GO:0098609|GO:0005887|GO:0043231|GO:0005737|GO:0001763|GO:0009887|GO:0031589|GO:0044236|GO:0031226|GO:0005783|GO:0001503|GO:0060348|GO:0048869|GO:0016021|GO:0005581|GO:0005539|GO:0048705|GO:0030574|GO:0044259|GO:0022617|GO:0007160|GO:0005788|GO:0060349|GO:0030198|GO:0030154|GO:0005600|GO:0001501|GO:0060350|GO:0001958|GO:0032963 developmental process|macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|binding|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|single organismal cell-cell adhesion|heparin binding|plasma membrane protein complex|multicellular organism development|animal organ development|anion binding|extracellular structure organization|cell-cell adhesion|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|morphogenesis of a branching structure|organ morphogenesis|cell-substrate adhesion|multicellular organism metabolic process|intrinsic component of plasma membrane|endoplasmic reticulum|ossification|bone development|cellular developmental process|integral component of membrane|collagen trimer|glycosaminoglycan binding|skeletal system morphogenesis|collagen catabolic process|multicellular organismal macromolecule metabolic process|extracellular matrix disassembly|cell-matrix adhesion|endoplasmic reticulum lumen|bone morphogenesis|extracellular matrix organization|cell differentiation|collagen type XIII trimer|skeletal system development|endochondral bone morphogenesis|endochondral ossification|collagen metabolic process K16617 collagen, type XIII, alpha[-] hsa04974 Protein digestion and absorption - Homo sapiens (human) 10:69801931-69964275 39 68 111 191 227 275 0.311085740460282 0.49295630822922 0.798285622547458 1.36505706805674 1.48564014089451 2.05580023848504 0.534109223745653 1.63549914914543 -1.61452430483594 2.61417808191229e-06 2.98104172870166e-05 DOWN ENSG00000092208 GEMIN2 gem nuclear organelle associated protein 2 [Source:HGNC Symbol;Acc:HGNC:10884] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0034719|GO:0005737|GO:0030529|GO:0006139|GO:0022613|GO:0032797|GO:0005730|GO:0005829|GO:0022618|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0034622|GO:0006396|GO:0034660|GO:0016604|GO:0016071|GO:0000387|GO:0000245|GO:0006397|GO:0097504|GO:0008380|GO:0000375|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|SMN-Sm protein complex|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|SMN complex|nucleolus|cytosol|ribonucleoprotein complex assembly|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|cellular macromolecular complex assembly|RNA processing|ncRNA metabolic process|nuclear body|mRNA metabolic process|spliceosomal snRNP assembly|spliceosomal complex assembly|mRNA processing|Gemini of coiled bodies|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome K13130 gem associated protein 2[-] hsa03013 RNA transport - Homo sapiens (human) 14:39114223-39136973 477 577 527 302 315 221 6.41350820349246 7.05071350014844 6.38854444012404 3.63816314486668 3.47500706816501 2.78482858087553 6.61758871458831 3.29933293130241 1.00413126475609 2.63790142243785e-06 3.00579805593357e-05 UP ENSG00000258568 RHOQP1 ras homolog family member Q pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:20003] - - - - - - 14:49599994-49600572 25 25 26 7 7 5 3.05429786723225 2.77584279211504 2.86383869354199 0.76620709696342 0.701672243598735 0.572537553780643 2.89799311762976 0.680138964780933 2.09115271820692 2.66364467708469e-06 3.03281648320696e-05 UP ENSG00000184208 C22orf46 chromosome 22 open reading frame 46 [Source:HGNC Symbol;Acc:HGNC:26294] GO:0005576 extracellular region - - - - 22:41688939-41698136 421 422 320 138 216 189 5.14338313482382 4.68554444329587 3.52477420589265 1.51057635037702 2.16515576386344 2.16399952416193 4.45123392800411 1.9465772128008 1.19326574981825 2.6687598294583e-06 3.03632454072592e-05 UP ENSG00000197062 ZSCAN26 zinc finger and SCAN domain containing 26 [Source:HGNC Symbol;Acc:HGNC:12978] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 6:28267010-28278224 388 414 300 186 169 174 2.6857697800095 2.60446265877782 1.87229164894196 1.15358194300802 0.959824112269639 1.12879934900493 2.38750802924309 1.08073513476086 1.14349259250839 2.67510357712862e-06 3.04238255967991e-05 UP ENSG00000140830 TXNL4B thioredoxin like 4B [Source:HGNC Symbol;Acc:HGNC:26041] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0030529|GO:0006139|GO:0022613|GO:0030532|GO:0022618|GO:0005681|GO:0010467|GO:0016070|GO:0005634|GO:0097525|GO:0034622|GO:0006396|GO:0016071|GO:0000245|GO:0005682|GO:0006397|GO:0097526|GO:0008380|GO:0000375|GO:0046540|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|small nuclear ribonucleoprotein complex|ribonucleoprotein complex assembly|spliceosomal complex|gene expression|RNA metabolic process|nucleus|spliceosomal snRNP complex|cellular macromolecular complex assembly|RNA processing|mRNA metabolic process|spliceosomal complex assembly|U5 snRNP|mRNA processing|spliceosomal tri-snRNP complex|RNA splicing|RNA splicing, via transesterification reactions|U4/U6 x U5 tri-snRNP complex|mRNA splicing, via spliceosome - - - - 16:72044289-72094431 730 741 620 392 426 296 8.61780479745007 7.95009714862552 6.59903054283316 4.14627180993368 4.12620838163058 3.27487461917033 7.72231082963625 3.84911827024486 1.00450462424559 2.73065364953628e-06 3.10437677278203e-05 UP ENSG00000268573 RP11-158H5.7 - - - - - - - 18:35280867-35290201 93 125 160 51 63 50 1.50125959115687 1.83385284905102 2.32866757783186 0.737637449938499 0.834416718711321 0.756437783977251 1.88792667267992 0.776163984209024 1.28236933589618 2.77553192555641e-06 3.15299581832424e-05 UP ENSG00000142687 KIAA0319L KIAA0319-like [Source:HGNC Symbol;Acc:HGNC:30071] GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0031982|GO:0005737|GO:0070062|GO:0016021|GO:0031410 cell|membrane|extracellular region|binding|extracellular vesicle|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|vesicle|cytoplasm|extracellular exosome|integral component of membrane|cytoplasmic vesicle - - - - 1:35433490-35557950 451 451 675 1029 1103 1246 2.26998205215402 2.06301434910475 3.0631196634371 4.64043583706542 4.55500741877391 5.87750140194577 2.46537202156529 5.02431488592837 -1.02712152032601 2.79167168727236e-06 3.17012425073523e-05 DOWN ENSG00000125872 LRRN4 leucine rich repeat neuronal 4 [Source:HGNC Symbol;Acc:HGNC:16208] GO:0007610|GO:0005623|GO:0016020|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0009628|GO:0043227|GO:0044708|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0009314|GO:0050877|GO:0031982|GO:0007632|GO:0005887|GO:0031226|GO:0070062|GO:0007611|GO:0016021|GO:0007612|GO:0007613|GO:0050890|GO:0009416|GO:0008542|GO:0008306|GO:0007616 behavior|cell|membrane|extracellular region|response to stimulus|binding|extracellular vesicle|response to abiotic stimulus|membrane-bounded organelle|single-organism behavior|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|response to radiation|neurological system process|vesicle|visual behavior|integral component of plasma membrane|intrinsic component of plasma membrane|extracellular exosome|learning or memory|integral component of membrane|learning|memory|cognition|response to light stimulus|visual learning|associative learning|long-term memory - - - - 20:6040778-6054049 42 37 27 8 12 9 1.10361893228853 0.88360349241584 0.639663458296581 0.188353202397726 0.258717728182601 0.221635299089846 0.875628627666984 0.222902076556724 1.97390906572494 2.80326779150307e-06 3.18208200180732e-05 UP ENSG00000183647 ZNF530 zinc finger protein 530 [Source:HGNC Symbol;Acc:HGNC:29297] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57599885-57612722 245 302 260 133 139 134 1.73097794488231 1.9391495433359 1.65620186066951 0.841926175065403 0.805763219465541 0.887277082363229 1.77544311629591 0.844988825631391 1.07117497033289 2.81440274124241e-06 3.19350739023379e-05 UP ENSG00000008300 CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 [Source:HGNC Symbol;Acc:HGNC:3230] GO:0040011|GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0006935|GO:0048468|GO:0007275|GO:0022607|GO:0098609|GO:0043169|GO:0004888|GO:0032880|GO:0006928|GO:0008037|GO:0008104|GO:0007154|GO:0016477|GO:0007165|GO:0030030|GO:0048869|GO:0016021|GO:0019538|GO:0031323|GO:0006996|GO:0032268|GO:0000902|GO:0031175|GO:0007186|GO:0098742|GO:0046872|GO:0007166|GO:0043412|GO:0000904|GO:0036211|GO:0044782|GO:0001764|GO:0030031|GO:0008038|GO:0070925|GO:0006796|GO:0042384|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:0004930|GO:0048666|GO:0030182|GO:0060271|GO:0007411|GO:0007413|GO:0016310|GO:0005509|GO:0061564|GO:0007156|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0036515|GO:0007409|GO:0006468|GO:0048699|GO:0042325|GO:0036514|GO:0001932 locomotion|developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|chemotaxis|cell development|multicellular organism development|cellular component assembly|cell-cell adhesion|cation binding|transmembrane signaling receptor activity|regulation of protein localization|movement of cell or subcellular component|cell recognition|protein localization|cell communication|cell migration|signal transduction|cell projection organization|cellular developmental process|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|G-protein coupled receptor signaling pathway|cell-cell adhesion via plasma-membrane adhesion molecules|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|cell morphogenesis involved in differentiation|protein modification process|cilium organization|neuron migration|cell projection assembly|neuron recognition|organelle assembly|phosphate-containing compound metabolic process|cilium assembly|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|G-protein coupled receptor activity|neuron development|neuron differentiation|cilium morphogenesis|axon guidance|axonal fasciculation|phosphorylation|calcium ion binding|axon development|homophilic cell adhesion via plasma membrane adhesion molecules|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|serotonergic neuron axon guidance|axonogenesis|protein phosphorylation|generation of neurons|regulation of phosphorylation|dopaminergic neuron axon guidance|regulation of protein phosphorylation - - - - 3:48636469-48662915 364 387 301 159 164 190 1.43101259435404 1.38271640800632 1.06689785129538 0.560062408398848 0.528996982607655 0.700041293296019 1.29354228455191 0.596366894767507 1.11705513623096 2.82101561574187e-06 3.19857957433945e-05 UP ENSG00000119547 ONECUT2 one cut homeobox 2 [Source:HGNC Symbol;Acc:HGNC:8139] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0051272|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0030155|GO:0031325|GO:0046483|GO:2000147|GO:0090287|GO:0022607|GO:0043231|GO:0000981|GO:0071559|GO:0006928|GO:0009887|GO:0031018|GO:0031589|GO:0009966|GO:0010646|GO:0090288|GO:0006139|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0031016|GO:0030030|GO:0048869|GO:2000145|GO:0044249|GO:0010033|GO:0031323|GO:0048732|GO:0006996|GO:0000982|GO:0000902|GO:0003677|GO:0010468|GO:0034645|GO:0090101|GO:0007166|GO:0002064|GO:0051252|GO:0001889|GO:0010628|GO:0030334|GO:0044782|GO:0071560|GO:0007160|GO:0035270|GO:0031981|GO:0030031|GO:0010810|GO:0070848|GO:0005654|GO:0070925|GO:0060429|GO:0042384|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0048858|GO:0001228|GO:0030335|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0045165|GO:0007422|GO:0048666|GO:0030182|GO:0060271|GO:0015629|GO:0000975|GO:0045893|GO:0030855|GO:0032774|GO:0048934|GO:0043565|GO:2001141|GO:0001077|GO:0071363|GO:0007179|GO:0003690|GO:0030512|GO:0007167|GO:0001952|GO:0022008|GO:0048935|GO:0017015|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0007178|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of cellular component movement|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell motility|regulation of cellular response to growth factor stimulus|cellular component assembly|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|endocrine pancreas development|cell-substrate adhesion|regulation of signal transduction|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|pancreas development|cell projection organization|cellular developmental process|regulation of cell motility|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|gland development|organelle organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|cell morphogenesis|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|epithelial cell development|regulation of RNA metabolic process|liver development|positive regulation of gene expression|regulation of cell migration|cilium organization|cellular response to transforming growth factor beta stimulus|cell-matrix adhesion|endocrine system development|nuclear lumen|cell projection assembly|regulation of cell-substrate adhesion|response to growth factor|nucleoplasm|organelle assembly|epithelium development|cilium assembly|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cell migration|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|cell fate commitment|peripheral nervous system development|neuron development|neuron differentiation|cilium morphogenesis|actin cytoskeleton|regulatory region DNA binding|positive regulation of transcription, DNA-templated|epithelial cell differentiation|RNA biosynthetic process|peripheral nervous system neuron differentiation|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cellular response to growth factor stimulus|transforming growth factor beta receptor signaling pathway|double-stranded DNA binding|negative regulation of transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|neurogenesis|peripheral nervous system neuron development|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transmembrane receptor protein serine/threonine kinase signaling pathway|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 18:57435685-57491297 94 141 257 407 445 588 0.401575445215123 0.547441721089906 0.989885583938644 1.55786576972576 1.55978843918599 2.3542024361563 0.646300916747891 1.82395221502268 -1.49678999029507 2.83666518304928e-06 3.21510259585244e-05 DOWN ENSG00000197557 TTC30A tetratricopeptide repeat domain 30A [Source:HGNC Symbol;Acc:HGNC:25853] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0051641|GO:0009653|GO:0016043|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0030992|GO:0006810|GO:0030990|GO:0022607|GO:0006928|GO:0045184|GO:0008104|GO:0010970|GO:0051649|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0015031|GO:0044782|GO:0046907|GO:0030031|GO:0007018|GO:0034613|GO:0070925|GO:0042384|GO:0032990|GO:0031503|GO:0048858|GO:0060271|GO:0042073|GO:0006886|GO:0030705 developmental process|macromolecular complex|cell|cellular process|binding|cell projection|cellular localization|anatomical structure morphogenesis|cellular component organization|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|intraciliary transport particle B|transport|intraciliary transport particle|cellular component assembly|movement of cell or subcellular component|establishment of protein localization|protein localization|establishment of localization by movement along microtubule|establishment of localization in cell|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|protein transport|cilium organization|intracellular transport|cell projection assembly|microtubule-based movement|cellular protein localization|organelle assembly|cilium assembly|cell part morphogenesis|protein complex localization|cell projection morphogenesis|cilium morphogenesis|intraciliary transport|intracellular protein transport|cytoskeleton-dependent intracellular transport - - - - 2:177612992-177618966 20 27 20 82 64 77 0.236776153960201 0.290508381722635 0.213483019235861 0.869797081024989 0.621660111736975 0.854332559805508 0.246922518306232 0.781929917522491 -1.66298089781285 2.84417004280726e-06 3.2223852925225e-05 DOWN ENSG00000260325 HSPB9 heat shock protein family B (small) member 9 [Source:HGNC Symbol;Acc:HGNC:30589] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nucleus - - - - 17:42121431-42123352 36 41 10 5 5 1 1.32494317795616 1.37138907903211 0.331831696132745 0.164865870930359 0.150988499075908 0.0344879008208731 1.00938798437367 0.11678075694238 3.11160634563411 2.85201163097838e-06 3.23004382516041e-05 UP ENSG00000114405 C3orf14 chromosome 3 open reading frame 14 [Source:HGNC Symbol;Acc:HGNC:25024] - - - - - - 3:62318973-62336213 39 41 20 181 212 76 0.510682774232096 0.487932212125087 0.23612755274607 2.12356859560511 2.27769626159382 0.932682580425804 0.411580846367751 1.77798247920824 -2.11099335689486 2.87728826116163e-06 3.2574351061327e-05 DOWN ENSG00000115966 ATF2 activating transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:784] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0019867|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0007507|GO:0002757|GO:0051726|GO:0042127|GO:0007049|GO:0045087|GO:0003712|GO:0006725|GO:0009888|GO:0006810|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0009414|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0010942|GO:0001817|GO:0045786|GO:0043231|GO:0043169|GO:0019899|GO:0016746|GO:0005737|GO:0000981|GO:0002218|GO:0001816|GO:0001076|GO:0009887|GO:0046983|GO:0050673|GO:0031966|GO:0009890|GO:0003682|GO:0001819|GO:0006139|GO:0050776|GO:0097186|GO:0007154|GO:0061024|GO:0007165|GO:0050778|GO:0003151|GO:0090559|GO:0051649|GO:0008134|GO:0008219|GO:0008285|GO:0006970|GO:0048869|GO:0010035|GO:0044249|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0006996|GO:0051090|GO:0003713|GO:0000165|GO:0051276|GO:0000982|GO:0005740|GO:0003677|GO:0010468|GO:0000075|GO:0034645|GO:0071636|GO:0046872|GO:1903047|GO:0043412|GO:0002758|GO:0072358|GO:0001085|GO:0010629|GO:0007005|GO:0005741|GO:0046982|GO:0051252|GO:0006325|GO:0008140|GO:1901216|GO:0003007|GO:0070997|GO:0016573|GO:0010628|GO:0036211|GO:0046902|GO:0000278|GO:0046907|GO:0003705|GO:0051091|GO:0035861|GO:0031981|GO:0031098|GO:0007346|GO:0045930|GO:0005654|GO:0005739|GO:0016747|GO:0050678|GO:0005694|GO:0002764|GO:0050680|GO:1901214|GO:0019900|GO:0012501|GO:0006796|GO:0035556|GO:0042476|GO:0044267|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0061448|GO:0001228|GO:0043068|GO:0016070|GO:0072359|GO:0033613|GO:0010557|GO:0005634|GO:0043067|GO:0045089|GO:0006974|GO:0060612|GO:0045088|GO:0007006|GO:0000975|GO:0045893|GO:0001102|GO:0045444|GO:0043065|GO:0045892|GO:0043523|GO:0007093|GO:0032774|GO:0006839|GO:0043565|GO:2001141|GO:0008637|GO:0001077|GO:0043525|GO:0016310|GO:0044774|GO:1902679|GO:0000077|GO:0002221|GO:0003690|GO:0016407|GO:1902108|GO:0035794|GO:0032915|GO:0016410|GO:0042981|GO:0042475|GO:0016568|GO:0051402|GO:0019901|GO:0006464|GO:0032909|GO:0051403|GO:0006351|GO:0006915|GO:0006355|GO:0044773|GO:0045944|GO:0006366|GO:1903507|GO:0002224|GO:0006357|GO:0006468|GO:1903506|GO:0044212|GO:0031573|GO:0018193|GO:1902110|GO:0008080|GO:0000122|GO:0035326|GO:0035497|GO:0034166|GO:0034134|GO:0038124|GO:0000976|GO:0001012|GO:0002756|GO:0034138|GO:0002755|GO:0034146|GO:0034142|GO:0006473|GO:0038123|GO:0018205|GO:0034162|GO:0018394|GO:0000977|GO:0001158|GO:0035666|GO:0006475|GO:0018393|GO:0000980|GO:0004402 developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|outer membrane|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|heart development|immune response-activating signal transduction|regulation of cell cycle|regulation of cell proliferation|cell cycle|innate immune response|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|transport|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|histone modification|nucleic acid binding|animal organ development|response to water deprivation|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|positive regulation of cell death|regulation of cytokine production|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|enzyme binding|transferase activity, transferring acyl groups|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|cytokine production|transcription factor activity, RNA polymerase II transcription factor binding|organ morphogenesis|protein dimerization activity|epithelial cell proliferation|mitochondrial membrane|negative regulation of biosynthetic process|chromatin binding|positive regulation of cytokine production|nucleobase-containing compound metabolic process|regulation of immune response|amelogenesis|cell communication|membrane organization|signal transduction|positive regulation of immune response|outflow tract morphogenesis|regulation of membrane permeability|establishment of localization in cell|transcription factor binding|cell death|negative regulation of cell proliferation|response to osmotic stress|cellular developmental process|response to inorganic substance|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|transcription coactivator activity|MAPK cascade|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|mitochondrial envelope|DNA binding|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|positive regulation of transforming growth factor beta production|metal ion binding|mitotic cell cycle process|macromolecule modification|innate immune response-activating signal transduction|cardiovascular system development|RNA polymerase II transcription factor binding|negative regulation of gene expression|mitochondrion organization|mitochondrial outer membrane|protein heterodimerization activity|regulation of RNA metabolic process|chromatin organization|cAMP response element binding protein binding|positive regulation of neuron death|heart morphogenesis|neuron death|histone acetylation|positive regulation of gene expression|protein modification process|regulation of mitochondrial membrane permeability|mitotic cell cycle|intracellular transport|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|positive regulation of sequence-specific DNA binding transcription factor activity|site of double-strand break|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|negative regulation of mitotic cell cycle|nucleoplasm|mitochondrion|transferase activity, transferring acyl groups other than amino-acyl groups|regulation of epithelial cell proliferation|chromosome|immune response-regulating signaling pathway|negative regulation of epithelial cell proliferation|regulation of neuron death|kinase binding|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|odontogenesis|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of programmed cell death|RNA metabolic process|circulatory system development|activating transcription factor binding|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|positive regulation of innate immune response|cellular response to DNA damage stimulus|adipose tissue development|regulation of innate immune response|mitochondrial membrane organization|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA polymerase II activating transcription factor binding|fat cell differentiation|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|mitotic cell cycle checkpoint|RNA biosynthetic process|mitochondrial transport|sequence-specific DNA binding|regulation of RNA biosynthetic process|apoptotic mitochondrial changes|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of neuron apoptotic process|phosphorylation|mitotic DNA integrity checkpoint|negative regulation of RNA biosynthetic process|DNA damage checkpoint|pattern recognition receptor signaling pathway|double-stranded DNA binding|acetyltransferase activity|regulation of mitochondrial membrane permeability involved in apoptotic process|positive regulation of mitochondrial membrane permeability|positive regulation of transforming growth factor beta2 production|N-acyltransferase activity|regulation of apoptotic process|odontogenesis of dentin-containing tooth|chromatin modification|neuron apoptotic process|protein kinase binding|cellular protein modification process|regulation of transforming growth factor beta2 production|stress-activated MAPK cascade|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|mitotic DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|intra-S DNA damage checkpoint|peptidyl-amino acid modification|positive regulation of mitochondrial membrane permeability involved in apoptotic process|N-acetyltransferase activity|negative regulation of transcription from RNA polymerase II promoter|enhancer binding|cAMP response element binding|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|protein acetylation|toll-like receptor TLR1:TLR2 signaling pathway|peptidyl-lysine modification|toll-like receptor 9 signaling pathway|peptidyl-lysine acetylation|RNA polymerase II regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding|TRIF-dependent toll-like receptor signaling pathway|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|RNA polymerase II distal enhancer sequence-specific DNA binding|histone acetyltransferase activity K04450 cyclic AMP-dependent transcription factor ATF-2[-] hsa04151|hsa05166|hsa04010|hsa05203|hsa05169|hsa05034|hsa05164|hsa04022|hsa04261|hsa05161|hsa04728|hsa04668|hsa04922|hsa04915|hsa04211|hsa04911|hsa04925|hsa04918|hsa05031|hsa05030 PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Influenza A - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human) 2:175072250-175168382 411 440 687 966 1205 1170 1.9682386244092 1.91500059333196 2.9662415290469 4.1448684473236 4.734680531968 5.25110374405833 2.28316024892935 4.71021757444998 -1.04476158033701 2.88909736543625e-06 3.2695645469194e-05 DOWN ENSG00000272871 RP11-408A13.4 - - - - - - - 9:14588797-14590065 0 0 0 9 13 4 0 0 0 0.449484329673357 0.594541552799828 0.208938519709119 0 0.417654800727435 -Inf 2.90910705098676e-06 3.29096179993022e-05 DOWN ENSG00000205181 LINC00654 long intergenic non-protein coding RNA 654 [Source:HGNC Symbol;Acc:HGNC:27154] - - - - - - 20:5496067-5504613 11 16 7 0 0 2 0.116273509101056 0.153705444301421 0.0667084563359422 0 0 0.0198104439263951 0.112229136579473 0.00660348130879837 4.08707665866643 2.91499526705648e-06 3.29637381449637e-05 UP ENSG00000179021 C3orf38 chromosome 3 open reading frame 38 [Source:HGNC Symbol;Acc:HGNC:28384] GO:0009987|GO:0008219|GO:0012501|GO:0006915 cellular process|cell death|programmed cell death|apoptotic process - - - - 3:88149743-88168729 818 876 615 423 445 316 12.3929687707226 12.0616272158022 8.40061413118352 5.74195136830508 5.53158641594381 4.48680759458637 10.9517367059028 5.25344845961175 1.05982301760137 2.93386362544606e-06 3.31645455032437e-05 UP ENSG00000105298 CACTIN cactin, spliceosome C complex subunit [Source:HGNC Symbol;Acc:HGNC:29938] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0002683|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0023057|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0019222|GO:0001818|GO:0002757|GO:0045087|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0031664|GO:0034641|GO:0006952|GO:0031982|GO:0046483|GO:0060761|GO:0001817|GO:0034122|GO:0043231|GO:0005737|GO:0002218|GO:0001816|GO:0030529|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0009617|GO:0050776|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0009968|GO:0070062|GO:0050777|GO:0031665|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0051090|GO:0032268|GO:0034340|GO:0010468|GO:0034645|GO:0032479|GO:0003723|GO:0007166|GO:0001959|GO:0033993|GO:0043412|GO:0002758|GO:0034097|GO:0010629|GO:0002237|GO:0051252|GO:0045824|GO:1903556|GO:0036211|GO:0032269|GO:0071219|GO:0032717|GO:0031981|GO:0032480|GO:0032606|GO:0005681|GO:0005654|GO:0043433|GO:0002764|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0051246|GO:0001960|GO:0009059|GO:0034121|GO:0016070|GO:0032496|GO:0005634|GO:0045089|GO:0045088|GO:0032637|GO:0032688|GO:0032680|GO:0032720|GO:0060339|GO:0019221|GO:0070555|GO:0006396|GO:0045892|GO:0060338|GO:0032774|GO:2001141|GO:0071357|GO:0016310|GO:1902679|GO:0032640|GO:0002221|GO:0016071|GO:0032608|GO:0071345|GO:0032088|GO:0044822|GO:0034612|GO:0006464|GO:0032648|GO:0071396|GO:0006351|GO:0006355|GO:0071013|GO:0071222|GO:0031663|GO:1903507|GO:0002224|GO:0071347|GO:0006468|GO:0071356|GO:1903506|GO:0042325|GO:0001932|GO:0006397|GO:0042326|GO:0008380|GO:0001933|GO:0060337|GO:0000375|GO:0000398 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|negative regulation of signaling|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|anatomical structure development|regulation of metabolic process|negative regulation of cytokine production|immune response-activating signal transduction|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|regulation of lipopolysaccharide-mediated signaling pathway|cellular nitrogen compound metabolic process|defense response|vesicle|heterocycle metabolic process|negative regulation of response to cytokine stimulus|regulation of cytokine production|negative regulation of toll-like receptor signaling pathway|intracellular membrane-bounded organelle|cytoplasm|activation of innate immune response|cytokine production|intracellular ribonucleoprotein complex|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|negative regulation of signal transduction|extracellular exosome|negative regulation of immune response|negative regulation of lipopolysaccharide-mediated signaling pathway|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of cellular protein metabolic process|response to type I interferon|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of type I interferon production|RNA binding|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|response to lipid|macromolecule modification|innate immune response-activating signal transduction|response to cytokine|negative regulation of gene expression|response to molecule of bacterial origin|regulation of RNA metabolic process|negative regulation of innate immune response|negative regulation of tumor necrosis factor superfamily cytokine production|protein modification process|negative regulation of cellular protein metabolic process|cellular response to molecule of bacterial origin|negative regulation of interleukin-8 production|nuclear lumen|negative regulation of type I interferon production|type I interferon production|spliceosomal complex|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|immune response-regulating signaling pathway|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|regulation of protein metabolic process|negative regulation of cytokine-mediated signaling pathway|macromolecule biosynthetic process|regulation of toll-like receptor signaling pathway|RNA metabolic process|response to lipopolysaccharide|nucleus|positive regulation of innate immune response|regulation of innate immune response|interleukin-8 production|negative regulation of interferon-beta production|regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor production|negative regulation of type I interferon-mediated signaling pathway|cytokine-mediated signaling pathway|response to interleukin-1|RNA processing|negative regulation of transcription, DNA-templated|regulation of type I interferon-mediated signaling pathway|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to type I interferon|phosphorylation|negative regulation of RNA biosynthetic process|tumor necrosis factor production|pattern recognition receptor signaling pathway|mRNA metabolic process|interferon-beta production|cellular response to cytokine stimulus|negative regulation of NF-kappaB transcription factor activity|poly(A) RNA binding|response to tumor necrosis factor|cellular protein modification process|regulation of interferon-beta production|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|catalytic step 2 spliceosome|cellular response to lipopolysaccharide|lipopolysaccharide-mediated signaling pathway|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|cellular response to interleukin-1|protein phosphorylation|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|mRNA processing|negative regulation of phosphorylation|RNA splicing|negative regulation of protein phosphorylation|type I interferon signaling pathway|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 19:3610641-3626815 803 889 575 387 389 388 5.1605040751211 5.19228698303501 3.33164459407478 2.22836272201276 2.05113392783613 2.33688679722659 4.56147855074363 2.20546114902516 1.04842118676058 2.93730099192213e-06 3.31908341456636e-05 UP ENSG00000157168 NRG1 neuregulin 1 [Source:HGNC Symbol;Acc:HGNC:7997] GO:0040011|GO:0032502|GO:0040007|GO:0004871|GO:0045499|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0040013|GO:0042995|GO:0009892|GO:0048523|GO:0031594|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0071704|GO:0009056|GO:0006955|GO:0009986|GO:0051051|GO:0044237|GO:0051641|GO:0045177|GO:0048870|GO:0023051|GO:0000989|GO:0044297|GO:0009653|GO:0030297|GO:0016043|GO:0045927|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0031252|GO:0009058|GO:0031224|GO:0005615|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0005886|GO:0007626|GO:0048856|GO:0019222|GO:0007507|GO:0060341|GO:0008284|GO:0042127|GO:0006935|GO:0045087|GO:0045595|GO:0009897|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:0051130|GO:0031643|GO:1901360|GO:0010941|GO:0031641|GO:0016324|GO:0007275|GO:0045596|GO:0048513|GO:0050877|GO:0032535|GO:0005102|GO:0016358|GO:0034641|GO:0030307|GO:0046620|GO:0008047|GO:0006952|GO:0030155|GO:0030900|GO:0003157|GO:0001964|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0022607|GO:0035265|GO:0051098|GO:0061061|GO:0005887|GO:0055017|GO:0045597|GO:0043231|GO:0019899|GO:0010243|GO:0005737|GO:0009611|GO:0060322|GO:0003161|GO:0032880|GO:0051222|GO:0006928|GO:0009887|GO:2000010|GO:0043005|GO:0009966|GO:0048729|GO:0045184|GO:0009890|GO:0048639|GO:0036477|GO:0060548|GO:0032388|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0050776|GO:0008104|GO:0007154|GO:0060996|GO:0046622|GO:0051270|GO:0061383|GO:0016477|GO:0007165|GO:0048588|GO:0032589|GO:0009968|GO:0048638|GO:0050808|GO:1901863|GO:0051649|GO:0045785|GO:0009725|GO:0008219|GO:0051271|GO:0031256|GO:0090316|GO:0008217|GO:0030546|GO:0050790|GO:0051048|GO:0030030|GO:0031253|GO:0019207|GO:0048869|GO:0016021|GO:2000145|GO:0021537|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0048732|GO:0003013|GO:0006996|GO:0003205|GO:0071774|GO:0060560|GO:0050768|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0060043|GO:0060998|GO:0031175|GO:0022029|GO:0031344|GO:0030879|GO:0051149|GO:0050905|GO:0010468|GO:0034645|GO:0007416|GO:0007166|GO:0003208|GO:0030424|GO:0043412|GO:0072594|GO:0072358|GO:0050773|GO:0030163|GO:0007417|GO:0010629|GO:0010720|GO:0007005|GO:0019887|GO:0042692|GO:0043069|GO:2001234|GO:0051252|GO:0005176|GO:0060421|GO:0035051|GO:0032386|GO:0048738|GO:0003007|GO:0010721|GO:0051223|GO:1903955|GO:0060420|GO:0015031|GO:1901652|GO:0060045|GO:0005125|GO:0031346|GO:0000904|GO:0050919|GO:0009790|GO:0071417|GO:0010628|GO:0045844|GO:0030334|GO:0051147|GO:0030971|GO:0051347|GO:0021885|GO:0036211|GO:0070201|GO:0060537|GO:0042060|GO:0046907|GO:0001764|GO:0044304|GO:0060999|GO:0051046|GO:0060485|GO:0050769|GO:0003231|GO:0043434|GO:0030425|GO:0044344|GO:0031644|GO:0008361|GO:0030673|GO:0051247|GO:0070848|GO:0022604|GO:0002764|GO:0006461|GO:0030336|GO:0034613|GO:0060038|GO:0019900|GO:0032270|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0042176|GO:0048864|GO:0010467|GO:0030516|GO:0032990|GO:0019209|GO:0007399|GO:0046903|GO:0071310|GO:0097485|GO:0060956|GO:0060415|GO:0031328|GO:0006626|GO:0051246|GO:0010770|GO:0009059|GO:0030154|GO:0048858|GO:1900006|GO:0007517|GO:1903827|GO:1902531|GO:0016070|GO:0008643|GO:0008083|GO:0072359|GO:0042177|GO:0008015|GO:0032870|GO:0010557|GO:0005634|GO:0043067|GO:1990138|GO:0061384|GO:0051960|GO:0045165|GO:0097190|GO:0048644|GO:0045773|GO:0008366|GO:0043125|GO:0007422|GO:0016202|GO:0043393|GO:0010638|GO:0043112|GO:0048666|GO:0030182|GO:2001237|GO:0050850|GO:0051896|GO:0003158|GO:0007411|GO:0043491|GO:0043241|GO:2000008|GO:0055024|GO:0051153|GO:0045893|GO:0048863|GO:2001222|GO:0010975|GO:0033365|GO:0033157|GO:0031401|GO:0008543|GO:0045445|GO:0010001|GO:0034622|GO:0043496|GO:0030855|GO:1901653|GO:0043408|GO:0010769|GO:0045892|GO:0014068|GO:0032774|GO:2001240|GO:0006839|GO:2001141|GO:0097192|GO:0014031|GO:0021842|GO:0043623|GO:2001236|GO:0071363|GO:0016310|GO:0051897|GO:0006605|GO:0072655|GO:0002768|GO:0038179|GO:1902679|GO:0010822|GO:0034394|GO:0048663|GO:0061564|GO:0016482|GO:0006886|GO:0048017|GO:0007167|GO:0021781|GO:0010821|GO:0030295|GO:0003222|GO:0071375|GO:0043410|GO:0051146|GO:0048709|GO:0042981|GO:2001223|GO:0003229|GO:0043066|GO:0032868|GO:0048762|GO:0051057|GO:0042552|GO:0043497|GO:0014066|GO:0051056|GO:0055008|GO:0019901|GO:0014706|GO:0050772|GO:0022008|GO:0048667|GO:0007264|GO:0055007|GO:0006464|GO:0045213|GO:0019932|GO:0055010|GO:0050767|GO:0048812|GO:1903214|GO:0097191|GO:0050848|GO:0051155|GO:0010976|GO:0043549|GO:0006351|GO:0010002|GO:0006915|GO:0006355|GO:0048675|GO:0033674|GO:0045666|GO:0014033|GO:0048011|GO:0060379|GO:1903533|GO:0000186|GO:0014032|GO:0045944|GO:0045446|GO:0006366|GO:0007265|GO:0046578|GO:0045859|GO:1903507|GO:0048015|GO:0008645|GO:0045860|GO:0006357|GO:0007409|GO:0006468|GO:0048699|GO:0043624|GO:1903506|GO:0046579|GO:0043405|GO:2001239|GO:0042325|GO:0001932|GO:0032869|GO:0018193|GO:0038093|GO:1990782|GO:0042063|GO:2000727|GO:0070886|GO:0070884|GO:0001934|GO:0019722|GO:0010657|GO:0048016|GO:0055012|GO:0007171|GO:0010656|GO:0030296|GO:0050770|GO:0045664|GO:0042327|GO:0070585|GO:0007169|GO:0048010|GO:0050731|GO:0050730|GO:0010664|GO:0061097|GO:0015758|GO:0038095|GO:0033173|GO:0014065|GO:0071900|GO:0061098|GO:0021830|GO:0032147|GO:0008286|GO:0038127|GO:0018108|GO:0007173|GO:0010659|GO:0010667 locomotion|developmental process|growth|signal transducer activity|chemorepellent activity|immune system process|synapse|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|negative regulation of locomotion|cell projection|negative regulation of metabolic process|negative regulation of cellular process|neuromuscular junction|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|organic substance metabolic process|catabolic process|immune response|cell surface|negative regulation of transport|cellular metabolic process|cellular localization|apical part of cell|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|cell body|anatomical structure morphogenesis|transmembrane receptor protein tyrosine kinase activator activity|cellular component organization|positive regulation of growth|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|biosynthetic process|intrinsic component of membrane|extracellular space|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|plasma membrane|locomotory behavior|anatomical structure development|regulation of metabolic process|heart development|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|chemotaxis|innate immune response|regulation of cell differentiation|external side of plasma membrane|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|transport|positive regulation of cellular component organization|positive regulation of myelination|organic cyclic compound metabolic process|regulation of cell death|regulation of myelination|apical plasma membrane|multicellular organism development|negative regulation of cell differentiation|animal organ development|neurological system process|regulation of cellular component size|receptor binding|dendrite development|cellular nitrogen compound metabolic process|positive regulation of cell growth|regulation of organ growth|enzyme activator activity|defense response|regulation of cell adhesion|forebrain development|endocardium development|startle response|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|cellular component assembly|organ growth|regulation of binding|muscle structure development|integral component of plasma membrane|cardiac muscle tissue growth|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|cytoplasm|response to wounding|head development|cardiac conduction system development|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|organ morphogenesis|positive regulation of protein localization to cell surface|neuron projection|regulation of signal transduction|tissue morphogenesis|establishment of protein localization|negative regulation of biosynthetic process|positive regulation of developmental growth|somatodendritic compartment|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|regulation of immune response|protein localization|cell communication|dendritic spine development|positive regulation of organ growth|regulation of cellular component movement|trabecula morphogenesis|cell migration|signal transduction|developmental cell growth|neuron projection membrane|negative regulation of signal transduction|regulation of developmental growth|synapse organization|positive regulation of muscle tissue development|establishment of localization in cell|positive regulation of cell adhesion|response to hormone|cell death|negative regulation of cellular component movement|leading edge membrane|positive regulation of intracellular protein transport|regulation of blood pressure|receptor activator activity|regulation of catalytic activity|negative regulation of secretion|cell projection organization|cell projection membrane|kinase regulator activity|cellular developmental process|integral component of membrane|regulation of cell motility|telencephalon development|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|gland development|circulatory system process|organelle organization|cardiac chamber development|response to fibroblast growth factor|developmental growth involved in morphogenesis|negative regulation of neurogenesis|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|regulation of cardiac muscle cell proliferation|regulation of dendritic spine development|neuron projection development|telencephalon cell migration|regulation of cell projection organization|mammary gland development|positive regulation of muscle cell differentiation|neuromuscular process|regulation of gene expression|cellular macromolecule biosynthetic process|synapse assembly|cell surface receptor signaling pathway|cardiac ventricle morphogenesis|axon|macromolecule modification|establishment of protein localization to organelle|cardiovascular system development|regulation of dendrite development|protein catabolic process|central nervous system development|negative regulation of gene expression|positive regulation of cell development|mitochondrion organization|protein kinase regulator activity|muscle cell differentiation|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|ErbB-2 class receptor binding|positive regulation of heart growth|cardiocyte differentiation|regulation of intracellular transport|cardiac muscle tissue development|heart morphogenesis|negative regulation of cell development|regulation of protein transport|positive regulation of protein targeting to mitochondrion|regulation of heart growth|protein transport|response to peptide|positive regulation of cardiac muscle cell proliferation|cytokine activity|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|negative chemotaxis|embryo development|cellular response to organonitrogen compound|positive regulation of gene expression|positive regulation of striated muscle tissue development|regulation of cell migration|regulation of muscle cell differentiation|receptor tyrosine kinase binding|positive regulation of transferase activity|forebrain cell migration|protein modification process|regulation of establishment of protein localization|muscle tissue development|wound healing|intracellular transport|neuron migration|main axon|positive regulation of dendritic spine development|regulation of secretion|mesenchyme development|positive regulation of neurogenesis|cardiac ventricle development|response to peptide hormone|dendrite|cellular response to fibroblast growth factor stimulus|regulation of neurological system process|regulation of cell size|axolemma|positive regulation of protein metabolic process|response to growth factor|regulation of cell morphogenesis|immune response-regulating signaling pathway|protein complex assembly|negative regulation of cell migration|cellular protein localization|cardiac muscle cell proliferation|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|stem cell development|gene expression|regulation of axon extension|cell part morphogenesis|kinase activator activity|nervous system development|secretion|cellular response to organic substance|neuron projection guidance|endocardial cell differentiation|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|protein targeting to mitochondrion|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of dendrite development|muscle organ development|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|carbohydrate transport|growth factor activity|circulatory system development|negative regulation of protein catabolic process|blood circulation|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|neuron projection extension|heart trabecula morphogenesis|regulation of nervous system development|cell fate commitment|apoptotic signaling pathway|muscle organ morphogenesis|positive regulation of axon extension|axon ensheathment|ErbB-3 class receptor binding|peripheral nervous system development|regulation of striated muscle tissue development|regulation of protein binding|positive regulation of organelle organization|receptor metabolic process|neuron development|neuron differentiation|negative regulation of extrinsic apoptotic signaling pathway|positive regulation of calcium-mediated signaling|regulation of protein kinase B signaling|endothelium development|axon guidance|protein kinase B signaling|protein complex disassembly|regulation of protein localization to cell surface|regulation of cardiac muscle tissue development|regulation of striated muscle cell differentiation|positive regulation of transcription, DNA-templated|stem cell differentiation|regulation of neuron migration|regulation of neuron projection development|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|myoblast differentiation|glial cell differentiation|cellular macromolecular complex assembly|regulation of protein homodimerization activity|epithelial cell differentiation|cellular response to peptide|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|positive regulation of phosphatidylinositol 3-kinase signaling|RNA biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|mitochondrial transport|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|mesenchymal cell development|chemorepulsion involved in interneuron migration from the subpallium to the cortex|cellular protein complex assembly|regulation of extrinsic apoptotic signaling pathway|cellular response to growth factor stimulus|phosphorylation|positive regulation of protein kinase B signaling|protein targeting|establishment of protein localization to mitochondrion|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|negative regulation of RNA biosynthetic process|positive regulation of mitochondrion organization|protein localization to cell surface|neuron fate commitment|axon development|cytosolic transport|intracellular protein transport|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|glial cell fate commitment|regulation of mitochondrion organization|protein kinase activator activity|ventricular trabecula myocardium morphogenesis|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|striated muscle cell differentiation|oligodendrocyte differentiation|regulation of apoptotic process|negative regulation of neuron migration|ventricular cardiac muscle tissue development|negative regulation of apoptotic process|response to insulin|mesenchymal cell differentiation|positive regulation of small GTPase mediated signal transduction|myelination|regulation of protein heterodimerization activity|regulation of phosphatidylinositol 3-kinase signaling|regulation of small GTPase mediated signal transduction|cardiac muscle tissue morphogenesis|protein kinase binding|striated muscle tissue development|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cardiac muscle cell differentiation|cellular protein modification process|neurotransmitter receptor metabolic process|second-messenger-mediated signaling|ventricular cardiac muscle tissue morphogenesis|regulation of neurogenesis|neuron projection morphogenesis|regulation of protein targeting to mitochondrion|extrinsic apoptotic signaling pathway|regulation of calcium-mediated signaling|positive regulation of striated muscle cell differentiation|positive regulation of neuron projection development|regulation of kinase activity|transcription, DNA-templated|cardioblast differentiation|apoptotic process|regulation of transcription, DNA-templated|axon extension|positive regulation of kinase activity|positive regulation of neuron differentiation|neural crest cell differentiation|neurotrophin TRK receptor signaling pathway|cardiac muscle cell myoblast differentiation|regulation of protein targeting|activation of MAPKK activity|neural crest cell development|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|phosphatidylinositol-mediated signaling|hexose transport|positive regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|axonogenesis|protein phosphorylation|generation of neurons|cellular protein complex disassembly|regulation of nucleic acid-templated transcription|positive regulation of Ras protein signal transduction|regulation of MAP kinase activity|regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|protein tyrosine kinase binding|gliogenesis|positive regulation of cardiac muscle cell differentiation|positive regulation of calcineurin-NFAT signaling cascade|regulation of calcineurin-NFAT signaling cascade|positive regulation of protein phosphorylation|calcium-mediated signaling|muscle cell apoptotic process|inositol phosphate-mediated signaling|ventricular cardiac muscle cell differentiation|activation of transmembrane receptor protein tyrosine kinase activity|negative regulation of muscle cell apoptotic process|protein tyrosine kinase activator activity|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|protein localization to mitochondrion|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|negative regulation of striated muscle cell apoptotic process|regulation of protein tyrosine kinase activity|glucose transport|Fc-epsilon receptor signaling pathway|calcineurin-NFAT signaling cascade|phosphatidylinositol 3-kinase signaling|regulation of protein serine/threonine kinase activity|positive regulation of protein tyrosine kinase activity|interneuron migration from the subpallium to the cortex|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|epidermal growth factor receptor signaling pathway|cardiac muscle cell apoptotic process|negative regulation of cardiac muscle cell apoptotic process K05455 neuregulin 1[-] hsa04012 ErbB signaling pathway - Homo sapiens (human) 8:31639386-32767959 11 18 16 73 65 40 0.0356649549848405 0.0530398972096645 0.0467731050074445 0.212065909371995 0.172914809332758 0.12154661038918 0.0451593190673165 0.168842443031311 -1.90258197156331 2.94858628845342e-06 3.32931524415614e-05 DOWN ENSG00000110427 KIAA1549L KIAA1549-like [Source:HGNC Symbol;Acc:HGNC:24836] GO:0002376|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0006950|GO:0009056|GO:0006914|GO:0016043|GO:0051707|GO:0009607|GO:0009605|GO:0031224|GO:0002682|GO:0050688|GO:0006952|GO:0033554|GO:0098542|GO:0009615|GO:0000422|GO:0016236|GO:0051607|GO:0016021|GO:0006996|GO:1903008|GO:0098792|GO:0000423|GO:0007005|GO:0050691|GO:0002230|GO:0098779 immune system process|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|response to stress|catabolic process|autophagy|cellular component organization|response to other organism|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|regulation of immune system process|regulation of defense response to virus|defense response|cellular response to stress|defense response to other organism|response to virus|mitophagy|macroautophagy|defense response to virus|integral component of membrane|organelle organization|organelle disassembly|xenophagy|macromitophagy|mitochondrion organization|regulation of defense response to virus by host|positive regulation of defense response to virus by host|mitophagy in response to mitochondrial depolarization - - - - 11:33542072-33674102 21 16 35 87 80 72 0.101774747419486 0.0704711450579002 0.152932203734455 0.377772943358763 0.318106473066899 0.32701684031234 0.10839269873728 0.340965418912667 -1.65335784600182 2.95538698043478e-06 3.33573243530813e-05 DOWN ENSG00000137522 RNF121 ring finger protein 121 [Source:HGNC Symbol;Acc:HGNC:21070] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0005783|GO:0019787|GO:0016021|GO:0019538|GO:0010033|GO:0036503|GO:0005794|GO:0046872|GO:0030968|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:0006986|GO:0030433|GO:0006508|GO:0044267|GO:0071310|GO:0000139|GO:0035967|GO:0034976|GO:0034620|GO:0044257|GO:0061630|GO:0010498|GO:0051603|GO:0046914|GO:0006464|GO:0019941|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0016567 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell communication|signal transduction|endoplasmic reticulum|ubiquitin-like protein transferase activity|integral component of membrane|protein metabolic process|response to organic substance|ERAD pathway|Golgi apparatus|metal ion binding|endoplasmic reticulum unfolded protein response|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|response to unfolded protein|ER-associated ubiquitin-dependent protein catabolic process|proteolysis|cellular protein metabolic process|cellular response to organic substance|Golgi membrane|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|cellular response to unfolded protein|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|proteolysis involved in cellular protein catabolic process|transition metal ion binding|cellular protein modification process|modification-dependent protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - 11:71928701-71997597 227 257 304 570 634 528 1.78553105639339 1.83719193361267 2.15589834539876 4.01710972310318 4.09165119095081 3.89227683731347 1.92620711180161 4.00034591712249 -1.05436192323887 2.96752416639048e-06 3.346924449559e-05 DOWN ENSG00000245573 BDNF-AS BDNF antisense RNA [Source:HGNC Symbol;Acc:HGNC:20608] - - - - - - 11:27506838-27698174 0 0 0 6 9 8 0 0 0 0.07292140280748 0.100160414738914 0.101698270330229 0 0.091593362625541 -Inf 2.96754505861281e-06 3.346924449559e-05 DOWN ENSG00000152484 USP12 ubiquitin specific peptidase 12 [Source:HGNC Symbol;Acc:HGNC:20485] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0009056|GO:0044237|GO:0016787|GO:0005515|GO:0008233|GO:0019538|GO:0036459|GO:0043412|GO:0030163|GO:0044265|GO:0036211|GO:0006508|GO:0044267|GO:0044257|GO:0051603|GO:0004175|GO:0070646|GO:0004843|GO:0008234|GO:0006464|GO:0019941|GO:0016579|GO:0004197|GO:0006511 cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|catabolic process|cellular metabolic process|hydrolase activity|protein binding|peptidase activity|protein metabolic process|thiol-dependent ubiquitinyl hydrolase activity|macromolecule modification|protein catabolic process|cellular macromolecule catabolic process|protein modification process|proteolysis|cellular protein metabolic process|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|endopeptidase activity|protein modification by small protein removal|thiol-dependent ubiquitin-specific protease activity|cysteine-type peptidase activity|cellular protein modification process|modification-dependent protein catabolic process|protein deubiquitination|cysteine-type endopeptidase activity|ubiquitin-dependent protein catabolic process - - - - 13:27066142-27171896 590 741 943 1490 1749 1560 7.59503616140772 8.66915052130375 10.9447014461489 17.1854894401422 18.4729320378411 18.820516446099 9.06962937628679 18.1596459746941 -1.00162057492172 2.96966622593857e-06 3.34805194521035e-05 DOWN ENSG00000143256 PFDN2 prefoldin subunit 2 [Source:HGNC Symbol;Acc:HGNC:8867] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0016043|GO:0006457|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0044183|GO:0051130|GO:0031982|GO:0051128|GO:0043231|GO:0005737|GO:0006458|GO:0070062|GO:0016272|GO:0051082|GO:0019538|GO:0006996|GO:0005730|GO:0007010|GO:0031981|GO:0005654|GO:0005739|GO:0033043|GO:0044267|GO:0051084|GO:0005634|GO:0010638|GO:0051493|GO:0051495 macromolecular complex|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular component organization|protein folding|membrane-bounded organelle|intracellular|protein binding|protein complex|protein binding involved in protein folding|positive regulation of cellular component organization|vesicle|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|'de novo' protein folding|extracellular exosome|prefoldin complex|unfolded protein binding|protein metabolic process|organelle organization|nucleolus|cytoskeleton organization|nuclear lumen|nucleoplasm|mitochondrion|regulation of organelle organization|cellular protein metabolic process|'de novo' posttranslational protein folding|nucleus|positive regulation of organelle organization|regulation of cytoskeleton organization|positive regulation of cytoskeleton organization - - - - 1:161100556-161118111 1541 1504 1155 762 861 586 139.571689456739 123.800542926443 94.3172186019495 61.8368844188309 63.9831958126418 49.7417572946486 119.229816995044 58.5206125087071 1.026728295423 2.97375334809565e-06 3.35139420362581e-05 UP ENSG00000114439 BBX bobby sox homolog (Drosophila) [Source:HGNC Symbol;Acc:HGNC:14422] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0060348|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0001501|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 developmental process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|bone development|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|skeletal system development|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 3:107522936-107811324 1110 1085 1593 2721 2432 3128 4.34328461249323 3.8583811278772 5.61985840639407 9.5394123932408 7.80776635635104 11.4707286327249 4.60717471558817 9.60596912743891 -1.06004886233087 2.97845720585164e-06 3.35542873296207e-05 DOWN ENSG00000122882 ECD ecdysoneless homolog (Drosophila) [Source:HGNC Symbol;Acc:HGNC:17029] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0044262|GO:0051726|GO:0007049|GO:0003712|GO:0006725|GO:0022402|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0005975|GO:0051186|GO:0006139|GO:0055086|GO:0006091|GO:0044249|GO:0031323|GO:0003713|GO:0006109|GO:0010468|GO:0034645|GO:1903047|GO:0019693|GO:0051252|GO:0044770|GO:0044275|GO:0000278|GO:0009116|GO:0031981|GO:0007346|GO:0010564|GO:0005654|GO:0016052|GO:0043467|GO:0006796|GO:0051174|GO:0010467|GO:0019439|GO:0009059|GO:0016070|GO:0046434|GO:0005634|GO:0006757|GO:0006110|GO:0009259|GO:0009117|GO:0032774|GO:0044772|GO:2001141|GO:0016310|GO:1901990|GO:0009132|GO:0006163|GO:0019752|GO:1901987|GO:0009166|GO:0006096|GO:0042278|GO:0006351|GO:0006355|GO:2000045|GO:0006366|GO:0046939|GO:1903578|GO:1903506|GO:0042325|GO:1902806|GO:0000082|GO:0032787|GO:0006165|GO:0046034|GO:0046031|GO:0006090 cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular carbohydrate metabolic process|regulation of cell cycle|cell cycle|transcription cofactor activity|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|generation of precursor metabolites and energy|cellular biosynthetic process|regulation of cellular metabolic process|transcription coactivator activity|regulation of carbohydrate metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|mitotic cell cycle process|ribose phosphate metabolic process|regulation of RNA metabolic process|cell cycle phase transition|cellular carbohydrate catabolic process|mitotic cell cycle|nucleoside metabolic process|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|carbohydrate catabolic process|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|gene expression|aromatic compound catabolic process|macromolecule biosynthetic process|RNA metabolic process|organophosphate catabolic process|nucleus|ATP generation from ADP|regulation of glycolytic process|ribonucleotide metabolic process|nucleotide metabolic process|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|phosphorylation|regulation of mitotic cell cycle phase transition|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|carboxylic acid metabolic process|regulation of cell cycle phase transition|nucleotide catabolic process|glycolytic process|purine nucleoside metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|nucleotide phosphorylation|regulation of ATP metabolic process|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of cell cycle G1/S phase transition|G1/S transition of mitotic cell cycle|monocarboxylic acid metabolic process|nucleoside diphosphate phosphorylation|ATP metabolic process|ADP metabolic process|pyruvate metabolic process - - - - 10:73130155-73169055 417 519 541 1118 1288 831 5.31769498807233 6.01498831867585 6.22012349512287 12.7740077232009 13.4763259022874 9.93156031195657 5.85093560062368 12.0606313124816 -1.04356618286077 3.00181130967198e-06 3.38046302674264e-05 DOWN ENSG00000130818 ZNF426 zinc finger protein 426 [Source:HGNC Symbol;Acc:HGNC:20725] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:9523224-9538627 415 545 552 209 286 300 2.97153426186263 3.54657455792598 3.56357427120493 1.34084233489727 1.6802241282727 2.01317863139786 3.36056103033118 1.67808169818928 1.00188914869767 3.02045713257101e-06 3.40017825172605e-05 UP ENSG00000176842 IRX5 iroquois homeobox 5 [Source:HGNC Symbol;Acc:HGNC:14361] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0044237|GO:0003006|GO:0009653|GO:0043227|GO:0008289|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0045137|GO:0006725|GO:0060041|GO:0009888|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0005496|GO:0048513|GO:0050877|GO:0034641|GO:0046483|GO:0043231|GO:0043178|GO:0048608|GO:0007423|GO:0009887|GO:0003407|GO:0048729|GO:0048598|GO:0048568|GO:0007548|GO:0019842|GO:0006139|GO:0008406|GO:0002027|GO:0048869|GO:0044249|GO:0031323|GO:0003013|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0001654|GO:0061458|GO:0051252|GO:0060040|GO:0009790|GO:0007600|GO:0060042|GO:0005499|GO:0010467|GO:0048562|GO:0007399|GO:0048701|GO:0009059|GO:0030154|GO:0001501|GO:0048469|GO:0016070|GO:0008015|GO:0005634|GO:0048666|GO:0030182|GO:0008016|GO:0048706|GO:0050953|GO:0042551|GO:0009792|GO:0043010|GO:0032774|GO:0043565|GO:0060047|GO:2001141|GO:0048704|GO:0022008|GO:0006351|GO:0006355|GO:0048592|GO:0048593|GO:0048699|GO:1903506|GO:0043009|GO:0007601 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|membrane-bounded organelle|lipid binding|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|development of primary sexual characteristics|cellular aromatic compound metabolic process|retina development in camera-type eye|tissue development|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|steroid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|alcohol binding|reproductive structure development|sensory organ development|organ morphogenesis|neural retina development|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|sex differentiation|vitamin binding|nucleobase-containing compound metabolic process|gonad development|regulation of heart rate|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|circulatory system process|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|eye development|reproductive system development|regulation of RNA metabolic process|retinal bipolar neuron differentiation|embryo development|sensory perception|retina morphogenesis in camera-type eye|vitamin D binding|gene expression|embryonic organ morphogenesis|nervous system development|embryonic cranial skeleton morphogenesis|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell maturation|RNA metabolic process|blood circulation|nucleus|neuron development|neuron differentiation|regulation of heart contraction|embryonic skeletal system development|sensory perception of light stimulus|neuron maturation|embryo development ending in birth or egg hatching|camera-type eye development|RNA biosynthetic process|sequence-specific DNA binding|heart contraction|regulation of RNA biosynthetic process|embryonic skeletal system morphogenesis|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|camera-type eye morphogenesis|generation of neurons|regulation of nucleic acid-templated transcription|chordate embryonic development|visual perception - - - - 16:54930862-54934485 271 332 151 95 109 71 2.74362245337954 3.05472796482769 1.37831003753623 0.861737023601995 0.905418649390948 0.673658516648232 2.39222015191449 0.813604729880392 1.55595019297288 3.03949542104385e-06 3.41903151092099e-05 UP ENSG00000136870 ZNF189 zinc finger protein 189 [Source:HGNC Symbol;Acc:HGNC:12980] GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0006914|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0005622|GO:0002682|GO:0019222|GO:0006725|GO:1901360|GO:0050688|GO:0003676|GO:0034641|GO:0006952|GO:0046483|GO:0033554|GO:0098542|GO:0043231|GO:0043169|GO:0009615|GO:0009890|GO:0006139|GO:0000422|GO:0016236|GO:0051607|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0003677|GO:0010468|GO:0034645|GO:1903008|GO:0046872|GO:0098792|GO:0000423|GO:0010629|GO:0007005|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0050691|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0002230|GO:0098779|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 immune system process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|autophagy|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|intracellular|regulation of immune system process|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of defense response to virus|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|heterocycle metabolic process|cellular response to stress|defense response to other organism|intracellular membrane-bounded organelle|cation binding|response to virus|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|mitophagy|macroautophagy|defense response to virus|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|organelle disassembly|metal ion binding|xenophagy|macromitophagy|negative regulation of gene expression|mitochondrion organization|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulation of defense response to virus by host|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|positive regulation of defense response to virus by host|mitophagy in response to mitochondrial depolarization|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 9:101398873-101410660 637 652 368 254 238 251 7.78227406180853 7.2392714688893 4.05349264241916 2.78034950197576 2.38567559000618 2.87389250299124 6.35834605770566 2.67997253165773 1.24643332448612 3.05529314620254e-06 3.43550740439663e-05 UP ENSG00000261126 RP11-795F19.1 - - - - - - - 18:80046900-80095482 46 39 48 12 18 15 0.447637421586654 0.344921613116189 0.421141800452402 0.10463203071702 0.143716209344735 0.13680385392304 0.404566945051748 0.128384031328265 1.65591268178307 3.09010946073398e-06 3.47334818677531e-05 UP ENSG00000102870 ZNF629 zinc finger protein 629 [Source:HGNC Symbol;Acc:HGNC:29008] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 16:30778449-30787202 1295 1394 906 595 616 652 15.0491601526331 14.7226253978732 9.49259843030067 6.19522868341248 5.87341677561112 7.10099158469741 13.0881279936023 6.38987901457367 1.03439824142687 3.11655807057332e-06 3.49912465734847e-05 UP ENSG00000182670 TTC3 tetratricopeptide repeat domain 3 [Source:HGNC Symbol;Acc:HGNC:12393] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0043231|GO:0043169|GO:0005737|GO:0019787|GO:0019538|GO:0005730|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:0031981|GO:0006508|GO:0044267|GO:0005634|GO:0044257|GO:0051603|GO:0046914|GO:0006464|GO:0019941|GO:0008270|GO:0032446|GO:0006511|GO:0016567|GO:0000209|GO:0070936 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|ligase activity|intracellular|protein binding|transferase activity|intracellular membrane-bounded organelle|cation binding|cytoplasm|ubiquitin-like protein transferase activity|protein metabolic process|nucleolus|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|nuclear lumen|proteolysis|cellular protein metabolic process|nucleus|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|transition metal ion binding|cellular protein modification process|modification-dependent protein catabolic process|zinc ion binding|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination|protein K48-linked ubiquitination - - - - 21:37073226-37203112 1262 1508 2392 3445 3682 4944 4.10417594043331 4.45705361748279 7.01361602791909 10.0381451747169 9.82467506153647 15.0686362433761 5.1916151952784 11.6438188265432 -1.16530893771009 3.12325410211577e-06 3.50532435957008e-05 DOWN ENSG00000140832 MARVELD3 MARVEL domain containing 3 [Source:HGNC Symbol;Acc:HGNC:30525] GO:0040011|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0048870|GO:0023051|GO:0005911|GO:0016043|GO:0043227|GO:0023057|GO:0031224|GO:0005622|GO:0005515|GO:0019222|GO:0042127|GO:0010632|GO:0031982|GO:0033554|GO:0022607|GO:0019899|GO:0005737|GO:0006928|GO:0009966|GO:0050673|GO:0010646|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0051271|GO:0008285|GO:0006970|GO:0016021|GO:2000145|GO:0010633|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0043296|GO:2000146|GO:0000165|GO:0032268|GO:0090132|GO:0045216|GO:0043412|GO:0031410|GO:0030334|GO:0001667|GO:0036211|GO:0032269|GO:0034329|GO:0031098|GO:0050678|GO:0050680|GO:0030336|GO:0019900|GO:1902414|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:1902532|GO:0051246|GO:0005923|GO:1902531|GO:0043408|GO:0016310|GO:0010631|GO:0032872|GO:0043409|GO:0019901|GO:0006464|GO:0007043|GO:0051403|GO:0070830|GO:0043297|GO:0046328|GO:0006468|GO:0042325|GO:0007254|GO:0001932|GO:0042326|GO:0031435|GO:0001933|GO:0032873|GO:0046329 locomotion|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cell motility|regulation of signaling|cell-cell junction|cellular component organization|membrane-bounded organelle|negative regulation of signaling|intrinsic component of membrane|intracellular|protein binding|regulation of metabolic process|regulation of cell proliferation|regulation of epithelial cell migration|vesicle|cellular response to stress|cellular component assembly|enzyme binding|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|epithelial cell proliferation|regulation of cell communication|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|negative regulation of cellular component movement|negative regulation of cell proliferation|response to osmotic stress|integral component of membrane|regulation of cell motility|negative regulation of epithelial cell migration|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|apical junction complex|negative regulation of cell motility|MAPK cascade|regulation of cellular protein metabolic process|epithelium migration|cell-cell junction organization|macromolecule modification|cytoplasmic vesicle|regulation of cell migration|ameboidal-type cell migration|protein modification process|negative regulation of cellular protein metabolic process|cell junction assembly|stress-activated protein kinase signaling cascade|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of cell migration|kinase binding|protein localization to cell junction|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|negative regulation of intracellular signal transduction|regulation of protein metabolic process|bicellular tight junction|regulation of intracellular signal transduction|regulation of MAPK cascade|phosphorylation|epithelial cell migration|regulation of stress-activated MAPK cascade|negative regulation of MAPK cascade|protein kinase binding|cellular protein modification process|cell-cell junction assembly|stress-activated MAPK cascade|bicellular tight junction assembly|apical junction assembly|regulation of JNK cascade|protein phosphorylation|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|mitogen-activated protein kinase kinase kinase binding|negative regulation of protein phosphorylation|negative regulation of stress-activated MAPK cascade|negative regulation of JNK cascade - - - - 16:71626161-71642114 1132 1380 1008 641 707 373 8.06954589040221 8.94050172001888 6.47854557128326 4.0940993630376 4.13513805207221 2.49195664243742 7.82953106056812 3.57373135251574 1.13149471479544 3.14892121573977e-06 3.53147610723874e-05 UP ENSG00000236714 AC005592.1 - - - - - - - 5:142745600-142760998 0 0 0 5 7 16 0 0 0 0.14165051583735 0.181612976774103 0.474167617140945 0 0.265810369917466 -Inf 3.1485884592503e-06 3.53147610723874e-05 DOWN ENSG00000116171 SCP2 sterol carrier protein 2 [Source:HGNC Symbol;Acc:HGNC:10606] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0051641|GO:0042445|GO:0016043|GO:0043227|GO:0048037|GO:0008289|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0060341|GO:0044255|GO:0005504|GO:0006810|GO:1901360|GO:0006082|GO:0005496|GO:0043647|GO:0005102|GO:0043168|GO:0044281|GO:0031982|GO:0019637|GO:0043231|GO:0043178|GO:0016746|GO:0005737|GO:0043177|GO:0005319|GO:0032388|GO:0008104|GO:0061024|GO:0006629|GO:0008207|GO:0070062|GO:0042180|GO:0051649|GO:0042446|GO:0050662|GO:0010817|GO:0000062|GO:0044249|GO:0010876|GO:0010256|GO:0032370|GO:0006996|GO:0055114|GO:0015248|GO:0045940|GO:0005548|GO:0036042|GO:0016042|GO:0006066|GO:0044242|GO:0006631|GO:0032386|GO:0007009|GO:0032957|GO:0032934|GO:0034440|GO:0046907|GO:0006811|GO:0006700|GO:0072657|GO:0031981|GO:0032368|GO:0006869|GO:0007031|GO:0005654|GO:0005739|GO:0016747|GO:0032958|GO:0042448|GO:0034613|GO:0008202|GO:0006796|GO:0031406|GO:0008610|GO:0019216|GO:0036041|GO:0008206|GO:1901373|GO:0030258|GO:0005634|GO:0015914|GO:0033559|GO:0006820|GO:0015711|GO:0032376|GO:0006699|GO:0032959|GO:0006701|GO:0005777|GO:0072659|GO:0019218|GO:0001676|GO:0046395|GO:0005782|GO:0006694|GO:0015918|GO:0019752|GO:0070538|GO:0015485|GO:0008526|GO:0009062|GO:0019395|GO:1990778|GO:0032385|GO:0036109|GO:0006635|GO:0032366|GO:0033814|GO:0032374|GO:0030301|GO:0032787|GO:0033540|GO:0032367|GO:0032383 macromolecular complex|transporter activity|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular localization|hormone metabolic process|cellular component organization|membrane-bounded organelle|cofactor binding|lipid binding|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|regulation of cellular localization|cellular lipid metabolic process|fatty acid binding|transport|organic cyclic compound metabolic process|organic acid metabolic process|steroid binding|inositol phosphate metabolic process|receptor binding|anion binding|small molecule metabolic process|vesicle|organophosphate metabolic process|intracellular membrane-bounded organelle|alcohol binding|transferase activity, transferring acyl groups|cytoplasm|organic acid binding|lipid transporter activity|positive regulation of intracellular transport|protein localization|membrane organization|lipid metabolic process|C21-steroid hormone metabolic process|extracellular exosome|cellular ketone metabolic process|establishment of localization in cell|hormone biosynthetic process|coenzyme binding|regulation of hormone levels|fatty-acyl-CoA binding|cellular biosynthetic process|lipid localization|endomembrane system organization|positive regulation of lipid transport|organelle organization|oxidation-reduction process|sterol transporter activity|positive regulation of steroid metabolic process|phospholipid transporter activity|long-chain fatty acyl-CoA binding|lipid catabolic process|alcohol metabolic process|cellular lipid catabolic process|fatty acid metabolic process|regulation of intracellular transport|plasma membrane organization|inositol trisphosphate metabolic process|sterol binding|lipid oxidation|intracellular transport|ion transport|C21-steroid hormone biosynthetic process|protein localization to membrane|nuclear lumen|regulation of lipid transport|lipid transport|peroxisome organization|nucleoplasm|mitochondrion|transferase activity, transferring acyl groups other than amino-acyl groups|inositol phosphate biosynthetic process|progesterone metabolic process|cellular protein localization|steroid metabolic process|phosphate-containing compound metabolic process|carboxylic acid binding|lipid biosynthetic process|regulation of lipid metabolic process|long-chain fatty acid binding|bile acid metabolic process|lipid hydroperoxide transport|lipid modification|nucleus|phospholipid transport|unsaturated fatty acid metabolic process|anion transport|organic anion transport|positive regulation of cholesterol transport|bile acid biosynthetic process|inositol trisphosphate biosynthetic process|progesterone biosynthetic process|peroxisome|protein localization to plasma membrane|regulation of steroid metabolic process|long-chain fatty acid metabolic process|carboxylic acid catabolic process|peroxisomal matrix|steroid biosynthetic process|sterol transport|carboxylic acid metabolic process|oleic acid binding|cholesterol binding|phosphatidylinositol transporter activity|fatty acid catabolic process|fatty acid oxidation|protein localization to cell periphery|positive regulation of intracellular cholesterol transport|alpha-linolenic acid metabolic process|fatty acid beta-oxidation|intracellular sterol transport|propanoyl-CoA C-acyltransferase activity|regulation of cholesterol transport|cholesterol transport|monocarboxylic acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase|intracellular cholesterol transport|regulation of intracellular cholesterol transport K08764 sterol carrier protein 2[2.3.1.176] hsa01100|hsa04146|hsa03320|hsa00120 Metabolic pathways - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Primary bile acid biosynthesis - Homo sapiens (human) 1:52927229-53051703 914 1114 1418 2373 2276 2584 3.72599459873924 4.12725773482681 5.21178777887039 8.66745423225917 7.61266072721776 9.87228409779254 4.35501337081215 8.71746635242316 -1.00123174230507 3.19555571450215e-06 3.58243035301341e-05 DOWN ENSG00000123870 ZNF137P zinc finger protein 137, pseudogene [Source:HGNC Symbol;Acc:HGNC:12921] - - - - - - 19:52588505-52597345 23 17 25 4 4 6 0.730238482599256 0.490536157990148 0.715627435251781 0.11378968152035 0.104190604865145 0.178539043544304 0.645467358613728 0.1321731099766 2.28791544316541 3.20231718605613e-06 3.58866281053002e-05 UP ENSG00000087095 NLK nemo-like kinase [Source:HGNC Symbol;Acc:HGNC:29858] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0005057|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0043227|GO:0023057|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0071559|GO:0009966|GO:0019904|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0031647|GO:0008134|GO:0004702|GO:0000166|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0000165|GO:0030111|GO:0005829|GO:0010468|GO:0034645|GO:0030178|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0050821|GO:0051252|GO:0001883|GO:0036211|GO:0071560|GO:0032549|GO:0004707|GO:0031981|GO:0070848|GO:0005654|GO:0016301|GO:0006796|GO:0035556|GO:0042169|GO:0044267|GO:0010467|GO:0071310|GO:0017076|GO:0009059|GO:1902531|GO:0016070|GO:0016773|GO:0005634|GO:0044389|GO:0031625|GO:0016055|GO:0000287|GO:0032774|GO:0005524|GO:2001141|GO:0071363|GO:0030554|GO:0016310|GO:0007179|GO:0007167|GO:0004672|GO:0006464|GO:0006351|GO:0006355|GO:0007259|GO:0006468|GO:1903506|GO:0046425|GO:0018193|GO:0004674|GO:0007178|GO:0046777|GO:0042501|GO:0018105|GO:0018107|GO:0033136 signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|receptor signaling protein activity|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|response to transforming growth factor beta|regulation of signal transduction|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|regulation of protein stability|transcription factor binding|receptor signaling protein serine/threonine kinase activity|nucleotide binding|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|MAPK cascade|regulation of Wnt signaling pathway|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|protein stabilization|regulation of RNA metabolic process|purine nucleoside binding|protein modification process|cellular response to transforming growth factor beta stimulus|ribonucleoside binding|MAP kinase activity|nuclear lumen|response to growth factor|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|SH2 domain binding|cellular protein metabolic process|gene expression|cellular response to organic substance|purine nucleotide binding|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|Wnt signaling pathway|magnesium ion binding|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|protein kinase activity|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|JAK-STAT cascade|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of JAK-STAT cascade|peptidyl-amino acid modification|protein serine/threonine kinase activity|transmembrane receptor protein serine/threonine kinase signaling pathway|protein autophosphorylation|serine phosphorylation of STAT protein|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|serine phosphorylation of STAT3 protein K04468 nemo like kinase[2.7.11.24] hsa04010|hsa04310|hsa04068|hsa04520 MAPK signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Adherens junction - Homo sapiens (human) 17:28041737-28196381 118 119 182 337 386 304 1.06724945576996 0.978163837369536 1.48411606209349 2.73093082330454 2.86443647917621 2.57683227181189 1.17650978507766 2.72406652476421 -1.21124861645063 3.21780729061528e-06 3.6019654613434e-05 DOWN ENSG00000135775 COG2 component of oligomeric golgi complex 2 [Source:HGNC Symbol;Acc:HGNC:6546] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0044877|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0008565|GO:0006810|GO:0043231|GO:0005737|GO:0032403|GO:0045184|GO:0008104|GO:0051649|GO:0017119|GO:0010256|GO:0005794|GO:0006996|GO:0016192|GO:0005829|GO:0007030|GO:0015031|GO:0046907|GO:0005795|GO:0000139|GO:0048193|GO:0006891 macromolecular complex|transporter activity|cell|membrane|cellular process|binding|macromolecular complex binding|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|protein transporter activity|transport|intracellular membrane-bounded organelle|cytoplasm|protein complex binding|establishment of protein localization|protein localization|establishment of localization in cell|Golgi transport complex|endomembrane system organization|Golgi apparatus|organelle organization|vesicle-mediated transport|cytosol|Golgi organization|protein transport|intracellular transport|Golgi stack|Golgi membrane|Golgi vesicle transport|intra-Golgi vesicle-mediated transport - - - - 1:230642489-230693982 468 546 633 1084 1069 1335 2.35957458742451 2.50184802455365 2.87743922412236 4.89683078903601 4.4221522698371 6.30809777090642 2.57962061203351 5.20902694325984 -1.01385499700732 3.21704141269349e-06 3.6019654613434e-05 DOWN ENSG00000153292 ADGRF1 adhesion G protein-coupled receptor F1 [Source:HGNC Symbol;Acc:HGNC:18990] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0007166|GO:0004930 signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|G-protein coupled receptor activity - - - - 6:46997703-47042363 369 417 632 950 965 1325 1.4051416104343 1.44314359343399 2.16982455255508 3.24126605263283 3.01501055866408 4.72866135005056 1.67270325214112 3.66164598711582 -1.13031079107964 3.22573810826011e-06 3.6094897107945e-05 DOWN ENSG00000135605 TEC tec protein tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:11719] GO:0032502|GO:0040007|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0008289|GO:0071944|GO:0009605|GO:0009893|GO:0002684|GO:0048589|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0002757|GO:0042127|GO:0002250|GO:0050817|GO:0009898|GO:0045087|GO:0009888|GO:0043168|GO:0006952|GO:0005543|GO:0001882|GO:0016772|GO:0031325|GO:0042246|GO:0043169|GO:0005737|GO:0009611|GO:0031234|GO:0001775|GO:0098562|GO:0019897|GO:0050776|GO:0050865|GO:0007154|GO:0007165|GO:0050778|GO:0000166|GO:0048869|GO:0019538|GO:0031323|GO:0050878|GO:0032268|GO:0005829|GO:0030193|GO:0030168|GO:0046872|GO:0007166|GO:0035639|GO:0043412|GO:0007596|GO:0001883|GO:0036211|GO:0042060|GO:0032549|GO:0002429|GO:0007599|GO:0051247|GO:0002764|GO:0016301|GO:0010543|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:0030154|GO:0016773|GO:0005856|GO:0031401|GO:0005524|GO:0030554|GO:0016310|GO:0007229|GO:0002768|GO:0007167|GO:0004672|GO:0006464|GO:0050851|GO:0061041|GO:0006468|GO:0042325|GO:0004713|GO:0001932|GO:0018193|GO:0038093|GO:0001934|GO:0050853|GO:0042327|GO:0007169|GO:0004715|GO:0050731|GO:0050730|GO:0046777|GO:0038095|GO:0018108|GO:0038083 developmental process|growth|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|lipid binding|cell periphery|response to external stimulus|positive regulation of metabolic process|positive regulation of immune system process|developmental growth|intracellular|regulation of immune system process|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|immune response-activating signal transduction|regulation of cell proliferation|adaptive immune response|coagulation|cytoplasmic side of plasma membrane|innate immune response|tissue development|anion binding|defense response|phospholipid binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|tissue regeneration|cation binding|cytoplasm|response to wounding|extrinsic component of cytoplasmic side of plasma membrane|cell activation|cytoplasmic side of membrane|extrinsic component of plasma membrane|regulation of immune response|regulation of cell activation|cell communication|signal transduction|positive regulation of immune response|nucleotide binding|cellular developmental process|protein metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|regulation of cellular protein metabolic process|cytosol|regulation of blood coagulation|platelet activation|metal ion binding|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|blood coagulation|purine nucleoside binding|protein modification process|wound healing|ribonucleoside binding|immune response-activating cell surface receptor signaling pathway|hemostasis|positive regulation of protein metabolic process|immune response-regulating signaling pathway|kinase activity|regulation of platelet activation|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|positive regulation of protein modification process|ATP binding|adenyl nucleotide binding|phosphorylation|integrin-mediated signaling pathway|immune response-regulating cell surface receptor signaling pathway|enzyme linked receptor protein signaling pathway|protein kinase activity|cellular protein modification process|antigen receptor-mediated signaling pathway|regulation of wound healing|protein phosphorylation|regulation of phosphorylation|protein tyrosine kinase activity|regulation of protein phosphorylation|peptidyl-amino acid modification|Fc receptor signaling pathway|positive regulation of protein phosphorylation|B cell receptor signaling pathway|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|non-membrane spanning protein tyrosine kinase activity|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|protein autophosphorylation|Fc-epsilon receptor signaling pathway|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation K07364 tyrosine-protein kinase Tec[2.7.10.2] hsa04380|hsa04660 Osteoclast differentiation - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human) 4:48135783-48269864 28 35 76 153 170 130 0.373910897394283 0.424784972139947 0.915045960929347 1.83064334504049 1.86265920915004 1.62699729098723 0.571247276821192 1.77343328172592 -1.63435776784844 3.29122821090009e-06 3.67877977843806e-05 DOWN ENSG00000159164 SV2A synaptic vesicle glycoprotein 2A [Source:HGNC Symbol;Acc:HGNC:20566] GO:0005215|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0042995|GO:0030672|GO:0008021|GO:0004872|GO:0048786|GO:0022857|GO:0031594|GO:0043229|GO:0005911|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0043195|GO:0031982|GO:0043231|GO:0030133|GO:0019899|GO:0005737|GO:0012506|GO:0042592|GO:0043005|GO:0019725|GO:0030658|GO:0055085|GO:0005783|GO:0044306|GO:0016021|GO:0006836|GO:0030424|GO:0031410|GO:0048878|GO:0016023|GO:0070382|GO:0055082|GO:0043679|GO:0031988|GO:0019900|GO:0030659|GO:0050801|GO:0019901|GO:0006873|GO:0030003|GO:0055065|GO:0006875|GO:0006874|GO:0055074 transporter activity|synapse|cell|membrane|cellular process|cell junction|binding|cell projection|synaptic vesicle membrane|synaptic vesicle|receptor activity|presynaptic active zone|transmembrane transporter activity|neuromuscular junction|intracellular organelle|cell-cell junction|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|transport|terminal bouton|vesicle|intracellular membrane-bounded organelle|transport vesicle|enzyme binding|cytoplasm|vesicle membrane|homeostatic process|neuron projection|cellular homeostasis|transport vesicle membrane|transmembrane transport|endoplasmic reticulum|neuron projection terminus|integral component of membrane|neurotransmitter transport|axon|cytoplasmic vesicle|chemical homeostasis|cytoplasmic, membrane-bounded vesicle|exocytic vesicle|cellular chemical homeostasis|axon terminus|membrane-bounded vesicle|kinase binding|cytoplasmic vesicle membrane|ion homeostasis|protein kinase binding|cellular ion homeostasis|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis K06258 MFS transporter, VNT family, synaptic vesicle glycoprotein 2[-] hsa04512 ECM-receptor interaction - Homo sapiens (human) 1:149903318-149917882 27 22 9 1 5 1 0.375448317480598 0.278026468594364 0.112830566894742 0.0124530751918247 0.05704735506662 0.0130304197715192 0.255435117656568 0.0275102833433213 3.21491397891474 3.29135820600524e-06 3.67877977843806e-05 UP ENSG00000151229 SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 [Source:HGNC Symbol;Acc:HGNC:15956] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0006811|GO:0015075|GO:0051119|GO:0034219|GO:0008643|GO:0015293|GO:0015992|GO:0006812|GO:0035428|GO:0008324|GO:0015149|GO:0008645|GO:1904659|GO:0005351|GO:0015672|GO:0005355|GO:0015295|GO:0015758|GO:0046323 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|plasma membrane|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|ion transport|ion transmembrane transporter activity|sugar transmembrane transporter activity|carbohydrate transmembrane transport|carbohydrate transport|symporter activity|proton transport|cation transport|hexose transmembrane transport|cation transmembrane transporter activity|hexose transmembrane transporter activity|hexose transport|glucose transmembrane transport|sugar:proton symporter activity|monovalent inorganic cation transport|glucose transmembrane transporter activity|solute:proton symporter activity|glucose transport|glucose import - - - - 12:39755021-40106089 0 3 3 15 13 27 0 0.0174452682368706 0.0173013278297252 0.0859799882424254 0.0682348946823715 0.161881764985945 0.0115821986888653 0.105365549303581 -3.18542217911836 3.39160445887968e-06 3.78232945518842e-05 DOWN ENSG00000156427 FGF18 fibroblast growth factor 18 [Source:HGNC Symbol;Acc:HGNC:3674] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0048520|GO:0071704|GO:0006955|GO:0044237|GO:0050795|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0005615|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0008284|GO:0051272|GO:0042127|GO:0006935|GO:0045087|GO:0045595|GO:0009888|GO:0048468|GO:0035295|GO:0001568|GO:0007275|GO:0010632|GO:0030324|GO:0048513|GO:0005102|GO:0006952|GO:0061036|GO:0031325|GO:2000147|GO:0090287|GO:0045597|GO:0043231|GO:0010243|GO:0007267|GO:0050920|GO:0006928|GO:0009887|GO:0009966|GO:0030323|GO:0010646|GO:0043085|GO:0050776|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0001503|GO:0009725|GO:0010634|GO:0060348|GO:0050790|GO:0030030|GO:0048869|GO:2000145|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0050921|GO:0071774|GO:0000165|GO:1902533|GO:0005730|GO:0032268|GO:0000902|GO:0031175|GO:0048705|GO:0090132|GO:0051216|GO:0007166|GO:0030949|GO:0070851|GO:0001944|GO:0043412|GO:0072358|GO:0030947|GO:0060541|GO:0002063|GO:1901652|GO:0000904|GO:0071417|GO:0030334|GO:0001667|GO:0051347|GO:0036211|GO:0032330|GO:0031981|GO:0060326|GO:0043434|GO:2001028|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0060349|GO:0097485|GO:0010594|GO:0032332|GO:0051246|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0030335|GO:0061035|GO:1902531|GO:0008083|GO:0072359|GO:0032870|GO:0005634|GO:0010595|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:2000544|GO:2000546|GO:0005104|GO:1901653|GO:0043408|GO:0060350|GO:0002062|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0070371|GO:0035767|GO:0061564|GO:0048017|GO:0007167|GO:0001957|GO:0071375|GO:0043410|GO:0010631|GO:0001958|GO:0032868|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0035768|GO:0045859|GO:0048015|GO:0045860|GO:0043406|GO:0007409|GO:0005111|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0070374|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0005105|GO:0070372|GO:0043542|GO:0042327|GO:0007169|GO:0048010|GO:0038095|GO:0071902|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|behavior|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|positive regulation of behavior|organic substance metabolic process|immune response|cellular metabolic process|regulation of behavior|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|extracellular space|regulation of developmental process|intracellular|regulation of immune system process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|chemotaxis|innate immune response|regulation of cell differentiation|tissue development|cell development|tube development|blood vessel development|multicellular organism development|regulation of epithelial cell migration|lung development|animal organ development|receptor binding|defense response|positive regulation of cartilage development|positive regulation of cellular metabolic process|positive regulation of cell motility|regulation of cellular response to growth factor stimulus|positive regulation of cell differentiation|intracellular membrane-bounded organelle|response to organonitrogen compound|cell-cell signaling|regulation of chemotaxis|movement of cell or subcellular component|organ morphogenesis|regulation of signal transduction|respiratory tube development|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|ossification|response to hormone|positive regulation of epithelial cell migration|bone development|regulation of catalytic activity|cell projection organization|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|positive regulation of chemotaxis|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|nucleolus|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|skeletal system morphogenesis|epithelium migration|cartilage development|cell surface receptor signaling pathway|positive regulation of vascular endothelial growth factor receptor signaling pathway|growth factor receptor binding|vasculature development|macromolecule modification|cardiovascular system development|regulation of vascular endothelial growth factor receptor signaling pathway|respiratory system development|chondrocyte development|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|regulation of cell migration|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|regulation of chondrocyte differentiation|nuclear lumen|cell chemotaxis|response to peptide hormone|positive regulation of endothelial cell chemotaxis|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|bone morphogenesis|neuron projection guidance|regulation of endothelial cell migration|positive regulation of chondrocyte differentiation|regulation of protein metabolic process|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|positive regulation of cell migration|regulation of cartilage development|regulation of intracellular signal transduction|growth factor activity|circulatory system development|cellular response to hormone stimulus|nucleus|positive regulation of endothelial cell migration|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|regulation of endothelial cell chemotaxis to fibroblast growth factor|positive regulation of endothelial cell chemotaxis to fibroblast growth factor|fibroblast growth factor receptor binding|cellular response to peptide|regulation of MAPK cascade|endochondral bone morphogenesis|chondrocyte differentiation|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|ERK1 and ERK2 cascade|endothelial cell chemotaxis|axon development|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|intramembranous ossification|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|epithelial cell migration|endochondral ossification|response to insulin|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|endothelial cell chemotaxis to fibroblast growth factor|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|axonogenesis|type 2 fibroblast growth factor receptor binding|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|type 1 fibroblast growth factor receptor binding|regulation of ERK1 and ERK2 cascade|endothelial cell migration|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K04358 fibroblast growth factor[-] hsa05200|hsa04151|hsa04010|hsa04014|hsa04810|hsa04015|hsa05218 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Melanoma - Homo sapiens (human) 5:171419656-171457623 42 27 8 3 3 3 1.49594268163179 0.87401187351095 0.256910582061283 0.0957253266437469 0.0876795374643122 0.100129524739755 0.875621712401341 0.0945114629492714 3.21174650457099 3.42588974008519e-06 3.81913787529885e-05 UP ENSG00000240356 RPL23AP7 ribosomal protein L23a pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:17336] - - - - - - 2:113610502-113627090 203 235 212 104 115 104 4.53843521442507 4.77482503578989 4.27326589176188 2.08325420874674 2.10947063993485 2.17906565116546 4.52884204732561 2.12393016661568 1.09240589122403 3.44709668294633e-06 3.84134469476221e-05 UP ENSG00000276291 FRG1HP FSHD region gene 1 family member H, pseudogene [Source:HGNC Symbol;Acc:HGNC:51767] - - - - - - 9:40992249-41218410 31 25 41 91 95 102 0.775128965293907 0.568120529033088 0.924284202663361 2.03868263466942 1.94896558685303 2.39024115572007 0.755844565663452 2.12596312574751 -1.49195508437653 3.55614703356537e-06 3.96138856492764e-05 DOWN ENSG00000171848 RRM2 ribonucleotide reductase M2 [Source:HGNC Symbol;Acc:HGNC:10452] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0005971|GO:0055086|GO:0044249|GO:0031323|GO:0055114|GO:0005829|GO:0009262|GO:0010468|GO:0034645|GO:0046872|GO:1903047|GO:0015949|GO:0051252|GO:0044770|GO:0000278|GO:0031981|GO:0005654|GO:0006259|GO:0006461|GO:0006796|GO:1901137|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000083|GO:0006260|GO:0051259|GO:0009117|GO:0032774|GO:0044772|GO:2001141|GO:0009132|GO:0009263|GO:0009165|GO:0006351|GO:0006355|GO:0004748|GO:0006366|GO:0006357|GO:0051291|GO:1903506|GO:0000082|GO:0051262|GO:0009186|GO:0051290 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|ribonucleoside-diphosphate reductase complex|nucleobase-containing small molecule metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|oxidation-reduction process|cytosol|deoxyribonucleotide metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|mitotic cell cycle process|nucleobase-containing small molecule interconversion|regulation of RNA metabolic process|cell cycle phase transition|mitotic cell cycle|nuclear lumen|nucleoplasm|DNA metabolic process|protein complex assembly|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulation of transcription involved in G1/S transition of mitotic cell cycle|DNA replication|protein oligomerization|nucleotide metabolic process|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|nucleoside diphosphate metabolic process|deoxyribonucleotide biosynthetic process|nucleotide biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|protein heterooligomerization|regulation of nucleic acid-templated transcription|G1/S transition of mitotic cell cycle|protein tetramerization|deoxyribonucleoside diphosphate metabolic process|protein heterotetramerization K10808 ribonucleoside-diphosphate reductase subunit M2[1.17.4.1] hsa01100|hsa00230|hsa00240|hsa04115|hsa00480 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human)|Glutathione metabolism - Homo sapiens (human) 2:10122328-10131419 1718 1853 2523 4545 5228 3481 12.6011917591875 12.3521902608674 16.6847629008295 29.868961135311 31.4624168696079 23.9288326466458 13.8793816402948 28.4200702171882 -1.03396682521019 3.57993460186236e-06 3.98491303519757e-05 DOWN ENSG00000115556 PLCD4 phospholipase C delta 4 [Source:HGNC Symbol;Acc:HGNC:9062] GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0019953|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0007340|GO:0012505|GO:0031090|GO:0044255|GO:0016788|GO:0019637|GO:0043231|GO:0043169|GO:0005737|GO:0005635|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0009566|GO:0031965|GO:0046486|GO:0046872|GO:0016042|GO:0007338|GO:0016298|GO:0006796|GO:0035556|GO:0005634|GO:0042578|GO:0006644|GO:0004620|GO:0008081|GO:0005509|GO:0006650|GO:0004629|GO:0046488|GO:0004435 signal transducer activity|reproduction|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|sexual reproduction|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|acrosome reaction|endomembrane system|organelle membrane|cellular lipid metabolic process|hydrolase activity, acting on ester bonds|organophosphate metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nuclear envelope|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|fertilization|nuclear membrane|glycerolipid metabolic process|metal ion binding|lipid catabolic process|single fertilization|lipase activity|phosphate-containing compound metabolic process|intracellular signal transduction|nucleus|phosphoric ester hydrolase activity|phospholipid metabolic process|phospholipase activity|phosphoric diester hydrolase activity|calcium ion binding|glycerophospholipid metabolic process|phospholipase C activity|phosphatidylinositol metabolic process|phosphatidylinositol phospholipase C activity K05857 phosphatidylinositol phospholipase C, delta[3.1.4.11] hsa01100|hsa04020|hsa04919|hsa04933|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 2:218607765-218637184 176 166 100 53 57 58 0.915890784037161 0.785087335034616 0.469187942541299 0.247119032652407 0.243371657366642 0.28287109903336 0.723388687204359 0.25778726301747 1.48859005292099 3.58335897760062e-06 3.98575256770823e-05 UP ENSG00000186976 EFCAB6 EF-hand calcium binding domain 6 [Source:HGNC Symbol;Acc:HGNC:24204] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0005509|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|calcium ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 22:43528744-43812337 6 6 18 40 42 47 0.0423638827798952 0.0385030757111616 0.114594223990901 0.253061487927864 0.243322956105211 0.311025467484045 0.0651537274939859 0.269136637172373 -2.04641917234835 3.58316274814877e-06 3.98575256770823e-05 DOWN ENSG00000088812 ATRN attractin [Source:HGNC Symbol;Acc:HGNC:885] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0004872|GO:0006950|GO:0030246|GO:0043473|GO:0043227|GO:0071944|GO:0040008|GO:0031224|GO:0005615|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0007275|GO:0048513|GO:0030902|GO:0006952|GO:0031982|GO:0007420|GO:0005887|GO:0005737|GO:0060322|GO:0035264|GO:0006979|GO:0031226|GO:0022037|GO:0070062|GO:0048638|GO:0040014|GO:0021549|GO:0016021|GO:0007417|GO:0006954|GO:0007399|GO:0008366|GO:0042552 developmental process|growth|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|receptor activity|response to stress|carbohydrate binding|pigmentation|membrane-bounded organelle|cell periphery|regulation of growth|intrinsic component of membrane|extracellular space|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|multicellular organism development|animal organ development|hindbrain development|defense response|vesicle|brain development|integral component of plasma membrane|cytoplasm|head development|multicellular organism growth|response to oxidative stress|intrinsic component of plasma membrane|metencephalon development|extracellular exosome|regulation of developmental growth|regulation of multicellular organism growth|cerebellum development|integral component of membrane|central nervous system development|inflammatory response|nervous system development|axon ensheathment|myelination - - - - 20:3471040-3651122 712 843 1417 2023 2272 2428 5.4965203483908 5.91446981628606 9.86261378509062 13.992702918729 14.390777490963 17.5665205810831 7.09120131658916 15.316666996925 -1.11100043242995 3.59003217555406e-06 3.99168791690841e-05 DOWN ENSG00000225422 RBMS1P1 RNA binding motif, single stranded interacting protein 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:9908] - - - - - - 12:66234079-66235234 18 10 22 49 80 60 1.10144497752238 0.556118530095757 1.21371141485637 2.68647543288653 4.01650699038449 3.4408636158442 0.957091640824836 3.38128201303841 -1.82084137460686 3.65861852555521e-06 4.06309425724826e-05 DOWN ENSG00000115844 DLX2 distal-less homeobox 2 [Source:HGNC Symbol;Acc:HGNC:2915] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0009653|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0021544|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0021766|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0030900|GO:0031325|GO:0046483|GO:0007420|GO:0043231|GO:0000981|GO:0007389|GO:0001763|GO:0060322|GO:0009887|GO:0009966|GO:0048598|GO:0048568|GO:0009890|GO:0021988|GO:0003682|GO:0010646|GO:0006139|GO:0007154|GO:0021772|GO:0007165|GO:0009968|GO:0021543|GO:0048869|GO:0021537|GO:0044249|GO:0031324|GO:0031323|GO:0050768|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0051216|GO:0003723|GO:0007166|GO:0007417|GO:0021895|GO:0010629|GO:0051252|GO:0010721|GO:0021761|GO:0009790|GO:0010628|GO:0003002|GO:0008593|GO:0021872|GO:0042476|GO:0010467|GO:0048562|GO:0007399|GO:0048701|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0051960|GO:0045165|GO:0045746|GO:0048755|GO:0030182|GO:0021953|GO:0048706|GO:0000975|GO:0045893|GO:0021892|GO:0009792|GO:0010001|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0048663|GO:0048709|GO:0042475|GO:0048704|GO:0060850|GO:0021879|GO:0009954|GO:0007219|GO:0022008|GO:0050767|GO:0003727|GO:0006351|GO:0006355|GO:0048715|GO:0045686|GO:0045944|GO:0006366|GO:1903507|GO:0021877|GO:0006357|GO:0048699|GO:0014013|GO:1903506|GO:0045685|GO:0044212|GO:0021882|GO:0042063|GO:0043009|GO:0000122|GO:0097154|GO:0048713|GO:0021893|GO:0000976|GO:0001012|GO:0000977 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|subpallium development|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|hippocampus development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|morphogenesis of a branching structure|head development|organ morphogenesis|regulation of signal transduction|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|olfactory lobe development|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|olfactory bulb development|signal transduction|negative regulation of signal transduction|pallium development|cellular developmental process|telencephalon development|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of neurogenesis|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|RNA binding|cell surface receptor signaling pathway|central nervous system development|cerebral cortex neuron differentiation|negative regulation of gene expression|regulation of RNA metabolic process|negative regulation of cell development|limbic system development|embryo development|positive regulation of gene expression|regionalization|regulation of Notch signaling pathway|forebrain generation of neurons|odontogenesis|gene expression|embryonic organ morphogenesis|nervous system development|embryonic cranial skeleton morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of nervous system development|cell fate commitment|negative regulation of Notch signaling pathway|branching morphogenesis of a nerve|neuron differentiation|central nervous system neuron differentiation|embryonic skeletal system development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|cerebral cortex GABAergic interneuron differentiation|embryo development ending in birth or egg hatching|glial cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|neuron fate commitment|oligodendrocyte differentiation|odontogenesis of dentin-containing tooth|embryonic skeletal system morphogenesis|regulation of transcription involved in cell fate commitment|forebrain neuron differentiation|proximal/distal pattern formation|Notch signaling pathway|neurogenesis|regulation of neurogenesis|single-stranded RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of oligodendrocyte differentiation|negative regulation of glial cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|forebrain neuron fate commitment|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of gliogenesis|regulation of nucleic acid-templated transcription|regulation of glial cell differentiation|transcription regulatory region DNA binding|regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment|gliogenesis|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|GABAergic neuron differentiation|regulation of oligodendrocyte differentiation|cerebral cortex GABAergic interneuron fate commitment|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 2:172099439-172102900 39 32 63 9 18 13 0.778636281795592 0.580636089904099 1.13404379149375 0.160992270492659 0.29485552518399 0.243255919675738 0.831105387731147 0.233034571784129 1.83448742711001 3.69304720712585e-06 4.09707288448662e-05 UP ENSG00000134716 CYP2J2 cytochrome P450 family 2 subfamily J member 2 [Source:HGNC Symbol;Acc:HGNC:2634] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0097159|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0044255|GO:0006082|GO:0009410|GO:0044281|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0004497|GO:0006629|GO:0005783|GO:0070062|GO:0006805|GO:0003013|GO:0055114|GO:0046872|GO:0020037|GO:0006631|GO:0008395|GO:0071466|GO:0016712|GO:0071614|GO:0008015|GO:0006690|GO:0008016|GO:0033559|GO:0070330|GO:0008392|GO:0060047|GO:0001676|GO:0019369|GO:0046914|GO:0019752|GO:0008405|GO:0005506|GO:0019373|GO:0008404|GO:0043651|GO:0032787 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|lipid metabolic process|endoplasmic reticulum|extracellular exosome|xenobiotic metabolic process|circulatory system process|oxidation-reduction process|metal ion binding|heme binding|fatty acid metabolic process|steroid hydroxylase activity|cellular response to xenobiotic stimulus|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|linoleic acid epoxygenase activity|blood circulation|icosanoid metabolic process|regulation of heart contraction|unsaturated fatty acid metabolic process|aromatase activity|arachidonic acid epoxygenase activity|heart contraction|long-chain fatty acid metabolic process|arachidonic acid metabolic process|transition metal ion binding|carboxylic acid metabolic process|arachidonic acid 11,12-epoxygenase activity|iron ion binding|epoxygenase P450 pathway|arachidonic acid 14,15-epoxygenase activity|linoleic acid metabolic process|monocarboxylic acid metabolic process K07418 cytochrome P450, family 2, subfamily J[1.14.14.1] hsa01100|hsa04726|hsa04750|hsa00590|hsa04913|hsa00591 Metabolic pathways - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human)|Ovarian steroidogenesis - Homo sapiens (human)|Linoleic acid metabolism - Homo sapiens (human) 1:59893308-59926790 308 315 305 131 189 152 4.67731457755867 4.34747328887178 4.1759994088331 1.78243949324627 2.35492532936432 2.16331099161022 4.40026242508785 2.10022527140694 1.06704548598027 3.75315681063486e-06 4.16066629872607e-05 UP ENSG00000278000 AC139100.4 - - - - - - - 18:80161752-80162413 60 60 41 11 21 19 6.41119722014592 5.82664369296702 3.94984895669886 1.05310773348816 1.84109469355136 1.90267401159735 5.3958966232706 1.59895881287896 1.75472993149722 3.76716727218034e-06 4.17464780043326e-05 UP ENSG00000111215 PRR4 proline rich 4 (lacrimal) [Source:HGNC Symbol;Acc:HGNC:18020] GO:0005576|GO:0005615|GO:0050877|GO:0042592|GO:0048871|GO:0001894|GO:0007600|GO:0050953|GO:0001895|GO:0007601 extracellular region|extracellular space|neurological system process|homeostatic process|multicellular organismal homeostasis|tissue homeostasis|sensory perception|sensory perception of light stimulus|retina homeostasis|visual perception - - - - 12:10845849-11171613 6 9 6 36 28 34 0.067980358431682 0.0926823872127976 0.0612955809675286 0.365472781616852 0.260303206178867 0.361043954804425 0.0739861088706694 0.328939980866715 -2.1524980399146 3.77741865177004e-06 4.1844547840424e-05 DOWN ENSG00000103707 MTFMT mitochondrial methionyl-tRNA formyltransferase [Source:HGNC Symbol;Acc:HGNC:29666] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0006413|GO:0005737|GO:0006139|GO:0044249|GO:0019538|GO:0006996|GO:0034645|GO:0006518|GO:0043412|GO:0007005|GO:0036211|GO:0005739|GO:0070124|GO:0043603|GO:0044267|GO:0010467|GO:0016742|GO:0009059|GO:0016070|GO:0032543|GO:0004479|GO:0043043|GO:0006396|GO:0034660|GO:0009451|GO:0006412|GO:0006464|GO:0006400|GO:0006399|GO:0008033|GO:0071951 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|translational initiation|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|organelle organization|cellular macromolecule biosynthetic process|peptide metabolic process|macromolecule modification|mitochondrion organization|protein modification process|mitochondrion|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|hydroxymethyl-, formyl- and related transferase activity|macromolecule biosynthetic process|RNA metabolic process|mitochondrial translation|methionyl-tRNA formyltransferase activity|peptide biosynthetic process|RNA processing|ncRNA metabolic process|RNA modification|translation|cellular protein modification process|tRNA modification|tRNA metabolic process|tRNA processing|conversion of methionyl-tRNA to N-formyl-methionyl-tRNA K00604 methionyl-tRNA formyltransferase[2.1.2.9] hsa00970|hsa00670 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)|One carbon pool by folate - Homo sapiens (human) 15:65001512-65029639 386 342 388 179 226 184 4.503449489695 3.62630006779511 4.0813486213405 1.87115618777126 2.16339298420207 2.01189650635147 4.0703660596102 2.01548189277493 1.0140337240214 3.79607416046767e-06 4.20044469928102e-05 UP ENSG00000115946 PNO1 partner of NOB1 homolog [Source:HGNC Symbol;Acc:HGNC:32790] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 2:68157844-68176238 1810 1950 1086 775 862 416 39.8983211036396 39.0652607049338 21.5834098668993 15.3064897961638 15.590177948242 8.59405590461216 33.5156638918242 13.1635745496727 1.34828420758415 3.79538710423618e-06 4.20044469928102e-05 UP ENSG00000271936 RP11-443B20.1 - - - - - - - 2:24825610-24826717 125 154 98 54 52 49 7.98025818112677 8.93523873662157 5.64089855502748 3.08884278370486 2.72383498620018 2.93179117690487 7.51879849092527 2.91482298226997 1.36709386572619 3.79497367808068e-06 4.20044469928102e-05 UP ENSG00000111269 CREBL2 cAMP responsive element binding protein-like 2 [Source:HGNC Symbol;Acc:HGNC:2350] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0019222|GO:0007049|GO:0045595|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0045597|GO:0043231|GO:0010828|GO:0006139|GO:0007154|GO:0006629|GO:0007165|GO:0031647|GO:0048869|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0003677|GO:0046326|GO:0010468|GO:0034645|GO:0043412|GO:0050821|GO:0051252|GO:0046889|GO:0010628|GO:0036211|GO:0045600|GO:0051247|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0008610|GO:0019216|GO:0045598|GO:0046890|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0016070|GO:0008643|GO:0010557|GO:0005634|GO:0010827|GO:0045893|GO:0045444|GO:0031401|GO:0032774|GO:0043565|GO:2001141|GO:0046324|GO:0016310|GO:0006464|GO:0006351|GO:0006355|GO:0008645|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0018193|GO:0001934|GO:0042327|GO:0015758|GO:0033138|GO:0018105|GO:0033135|GO:0046323 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|regulation of metabolic process|cell cycle|regulation of cell differentiation|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell differentiation|intracellular membrane-bounded organelle|positive regulation of glucose transport|nucleobase-containing compound metabolic process|cell communication|lipid metabolic process|signal transduction|regulation of protein stability|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|DNA binding|positive regulation of glucose import|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|protein stabilization|regulation of RNA metabolic process|positive regulation of lipid biosynthetic process|positive regulation of gene expression|protein modification process|positive regulation of fat cell differentiation|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|regulation of fat cell differentiation|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|carbohydrate transport|positive regulation of macromolecule biosynthetic process|nucleus|regulation of glucose transport|positive regulation of transcription, DNA-templated|fat cell differentiation|positive regulation of protein modification process|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of glucose import|phosphorylation|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|hexose transport|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|positive regulation of phosphorylation|glucose transport|positive regulation of peptidyl-serine phosphorylation|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|glucose import - - - - 12:12611827-12645108 443 508 888 1298 1383 1542 7.42041037093024 7.73336734678736 13.4107131681978 19.4803669430626 19.0070574059188 24.2068324463686 9.5214969619718 20.89808559845 -1.1341104722286 3.83798924865288e-06 4.24367892701049e-05 DOWN ENSG00000227400 AC012501.2 - - - - - - - 2:153421616-153593288 0 2 3 13 16 15 0 0.0819991097947315 0.122003049625811 0.525458561723743 0.592222443818308 0.634201029442969 0.0680007198068475 0.58396067832834 -3.10224930393543 3.84624581368e-06 4.25123371053693e-05 DOWN ENSG00000136536 MARCH7 membrane associated ring-CH-type finger 7 [Source:HGNC Symbol;Acc:HGNC:17393] GO:0032502|GO:0002376|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0002683|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0071704|GO:0043167|GO:0044237|GO:0007155|GO:0002507|GO:0016874|GO:0050793|GO:0002682|GO:0002520|GO:0048856|GO:0042127|GO:0016337|GO:0070661|GO:0007275|GO:0070489|GO:0030155|GO:0098609|GO:0043169|GO:0002643|GO:0001775|GO:0007162|GO:0046649|GO:0050865|GO:0002695|GO:0008285|GO:0019538|GO:0051249|GO:0032943|GO:0046872|GO:0043412|GO:0034109|GO:0036211|GO:0051250|GO:0022408|GO:0022407|GO:0007159|GO:0070664|GO:0042110|GO:0044267|GO:0046651|GO:1903038|GO:0042098|GO:0050863|GO:0050868|GO:0070486|GO:0046914|GO:0034111|GO:0032945|GO:0006464|GO:0050672|GO:0042130|GO:0042129|GO:0071593|GO:0008270|GO:0032446|GO:0016567 developmental process|immune system process|cellular process|metabolic process|binding|catalytic activity|negative regulation of immune system process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|organic substance metabolic process|ion binding|cellular metabolic process|cell adhesion|tolerance induction|ligase activity|regulation of developmental process|regulation of immune system process|immune system development|anatomical structure development|regulation of cell proliferation|single organismal cell-cell adhesion|leukocyte proliferation|multicellular organism development|T cell aggregation|regulation of cell adhesion|cell-cell adhesion|cation binding|regulation of tolerance induction|cell activation|negative regulation of cell adhesion|lymphocyte activation|regulation of cell activation|negative regulation of leukocyte activation|negative regulation of cell proliferation|protein metabolic process|regulation of lymphocyte activation|mononuclear cell proliferation|metal ion binding|macromolecule modification|homotypic cell-cell adhesion|protein modification process|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|negative regulation of leukocyte proliferation|T cell activation|cellular protein metabolic process|lymphocyte proliferation|negative regulation of leukocyte cell-cell adhesion|T cell proliferation|regulation of T cell activation|negative regulation of T cell activation|leukocyte aggregation|transition metal ion binding|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|cellular protein modification process|negative regulation of lymphocyte proliferation|negative regulation of T cell proliferation|regulation of T cell proliferation|lymphocyte aggregation|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 2:159712457-159771027 553 658 834 1241 1543 1535 3.82305340954163 4.13419718699604 5.19834769838063 7.68696024035203 8.75223900172158 9.94540487554926 4.38519943163943 8.79486803920762 -1.00401947568438 3.85195960955463e-06 4.25597343388764e-05 DOWN ENSG00000172031 EPHX4 epoxide hydrolase 4 [Source:HGNC Symbol;Acc:HGNC:23758] GO:0016020|GO:0008152|GO:0003824|GO:0016787|GO:0031224|GO:0016021 membrane|metabolic process|catalytic activity|hydrolase activity|intrinsic component of membrane|integral component of membrane - - - - 1:92029982-92063536 264 277 192 115 122 87 7.65663059067292 7.30119438317348 5.02052162427237 2.98834507422871 2.90308869774397 2.36472530355289 6.65944886603959 2.75205302517519 1.27489451780349 3.86101479655488e-06 4.26440013822973e-05 UP ENSG00000213625 LEPROT leptin receptor overlapping transcript [Source:HGNC Symbol;Acc:HGNC:29477] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:1903828|GO:0023057|GO:0031224|GO:0005622|GO:1903829|GO:0005515|GO:0012505|GO:0031090|GO:0060341|GO:0006810|GO:0051130|GO:0005102|GO:0051128|GO:0043231|GO:0010243|GO:0005737|GO:0032880|GO:0051222|GO:0009966|GO:0045184|GO:2000009|GO:0032388|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0051649|GO:0009725|GO:0090316|GO:0010008|GO:0016021|GO:0010033|GO:0005794|GO:0005768|GO:0006996|GO:0007166|GO:0072594|GO:0007005|GO:0032386|GO:0051223|GO:1903955|GO:0015031|GO:1901652|GO:0060400|GO:0071417|GO:0070201|GO:0046907|GO:0043434|GO:0060398|GO:0034613|GO:0035556|GO:0033043|GO:0071310|GO:0000139|GO:1902532|GO:0006626|GO:1903827|GO:1902531|GO:0032870|GO:0010638|GO:2000008|GO:0033365|GO:0033157|GO:1901653|GO:0006839|GO:0006605|GO:0072655|GO:0010822|GO:0034394|GO:0060416|GO:0016482|GO:0006886|GO:0007167|GO:0010821|GO:0071375|GO:1903214|GO:1903533|GO:0007259|GO:0046425|GO:0071378|GO:0046426|GO:0070585|GO:0007169|GO:0060396 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|negative regulation of cellular protein localization|negative regulation of signaling|intrinsic component of membrane|intracellular|positive regulation of cellular protein localization|protein binding|endomembrane system|organelle membrane|regulation of cellular localization|transport|positive regulation of cellular component organization|receptor binding|regulation of cellular component organization|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|regulation of protein localization|positive regulation of protein transport|regulation of signal transduction|establishment of protein localization|negative regulation of protein localization to cell surface|positive regulation of intracellular transport|regulation of cell communication|protein localization|cell communication|signal transduction|negative regulation of signal transduction|establishment of localization in cell|response to hormone|positive regulation of intracellular protein transport|endosome membrane|integral component of membrane|response to organic substance|Golgi apparatus|endosome|organelle organization|cell surface receptor signaling pathway|establishment of protein localization to organelle|mitochondrion organization|regulation of intracellular transport|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|response to peptide|negative regulation of growth hormone receptor signaling pathway|cellular response to organonitrogen compound|regulation of establishment of protein localization|intracellular transport|response to peptide hormone|regulation of growth hormone receptor signaling pathway|cellular protein localization|intracellular signal transduction|regulation of organelle organization|cellular response to organic substance|Golgi membrane|negative regulation of intracellular signal transduction|protein targeting to mitochondrion|regulation of cellular protein localization|regulation of intracellular signal transduction|cellular response to hormone stimulus|positive regulation of organelle organization|regulation of protein localization to cell surface|protein localization to organelle|regulation of intracellular protein transport|cellular response to peptide|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|protein localization to cell surface|response to growth hormone|cytosolic transport|intracellular protein transport|enzyme linked receptor protein signaling pathway|regulation of mitochondrion organization|cellular response to peptide hormone stimulus|regulation of protein targeting to mitochondrion|regulation of protein targeting|JAK-STAT cascade|regulation of JAK-STAT cascade|cellular response to growth hormone stimulus|negative regulation of JAK-STAT cascade|protein localization to mitochondrion|transmembrane receptor protein tyrosine kinase signaling pathway|growth hormone receptor signaling pathway - - - - 1:65420587-65436007 583 671 1018 1545 1664 1687 6.77836220181193 7.090205476613 10.6713327126579 16.0946934894213 15.8736912710679 18.3823282849343 8.17996679702761 16.7835710151412 -1.03688281618384 3.86898127371212e-06 4.27161860005184e-05 DOWN ENSG00000198265 HELZ helicase with zinc finger [Source:HGNC Symbol;Acc:HGNC:16878] GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0003676|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0043169|GO:0000166|GO:0016021|GO:0046872|GO:0003723|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0017076|GO:0005634|GO:0005524|GO:0030554|GO:0044822|GO:0016462|GO:0017111|GO:0004386 cell|membrane|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|nucleic acid binding|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|nucleotide binding|integral component of membrane|metal ion binding|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|purine nucleotide binding|nucleus|ATP binding|adenyl nucleotide binding|poly(A) RNA binding|pyrophosphatase activity|nucleoside-triphosphatase activity|helicase activity - - - - 17:67070438-67245989 340 410 679 1016 1002 1259 1.28010101333337 1.40290902180829 2.3048858823681 3.42733480036909 3.09528665194709 4.44242391028087 1.66263197250325 3.65501512086568 -1.13640851462236 3.87375562746721e-06 4.27530870618877e-05 DOWN ENSG00000136936 XPA xeroderma pigmentosum, complementation group A [Source:HGNC Symbol;Acc:HGNC:12814] GO:0032502|GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0045171|GO:0043227|GO:0009605|GO:0032993|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0042802|GO:0006281|GO:0006725|GO:0009314|GO:0009612|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0035264|GO:0046983|GO:0006979|GO:0019904|GO:0006139|GO:0007154|GO:0007165|GO:0008219|GO:0005662|GO:0005794|GO:0009636|GO:0003677|GO:0046872|GO:0005657|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0012501|GO:0035556|GO:0010996|GO:0006289|GO:0005634|GO:0009416|GO:0042803|GO:0006974|GO:0097190|GO:0097193|GO:0043596|GO:0009411|GO:0006283|GO:0003684|GO:0070911|GO:0008630|GO:0033683|GO:0090305|GO:0006915 developmental process|growth|macromolecular complex|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|intercellular bridge|membrane-bounded organelle|response to external stimulus|protein-DNA complex|developmental growth|intracellular|protein binding|protein complex|endomembrane system|identical protein binding|DNA repair|cellular aromatic compound metabolic process|response to radiation|response to mechanical stimulus|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|multicellular organism growth|protein dimerization activity|response to oxidative stress|protein domain specific binding|nucleobase-containing compound metabolic process|cell communication|signal transduction|cell death|DNA replication factor A complex|Golgi apparatus|response to toxic substance|DNA binding|metal ion binding|replication fork|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|programmed cell death|intracellular signal transduction|response to auditory stimulus|nucleotide-excision repair|nucleus|response to light stimulus|protein homodimerization activity|cellular response to DNA damage stimulus|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|nuclear replication fork|response to UV|transcription-coupled nucleotide-excision repair|damaged DNA binding|global genome nucleotide-excision repair|intrinsic apoptotic signaling pathway in response to DNA damage|nucleotide-excision repair, DNA incision|nucleic acid phosphodiester bond hydrolysis|apoptotic process K10847 DNA-repair protein complementing XP-A cells[-] hsa03420 Nucleotide excision repair - Homo sapiens (human) 9:97674909-97697357 62 72 91 225 192 173 1.63705848661177 1.72776623728742 2.16634410631451 5.3229604143141 4.15950564547749 4.28101690382727 1.84372294340457 4.58782765453962 -1.31518931836659 3.90651382201571e-06 4.30986931420758e-05 DOWN ENSG00000039139 DNAH5 dynein, axonemal, heavy chain 5 [Source:HGNC Symbol;Acc:HGNC:2950] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0043229|GO:0043167|GO:0048870|GO:0009653|GO:0016043|GO:0016787|GO:0005622|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0007507|GO:0005930|GO:0007275|GO:0048513|GO:0043168|GO:0005874|GO:0030900|GO:0001882|GO:0016817|GO:0007420|GO:0022607|GO:0007389|GO:0060322|GO:0030317|GO:0006928|GO:0005875|GO:0021670|GO:0000166|GO:0030030|GO:0048869|GO:0021537|GO:0007017|GO:0006996|GO:0000902|GO:0005858|GO:0070286|GO:0035639|GO:0007010|GO:0072358|GO:0007417|GO:0001883|GO:0035082|GO:0016818|GO:0044782|GO:0032549|GO:0030031|GO:0007018|GO:0030286|GO:0006461|GO:0070925|GO:0042384|GO:0021591|GO:0032990|GO:0007399|GO:0017076|GO:0048858|GO:0072359|GO:0000226|GO:0005856|GO:0060271|GO:0034622|GO:0005524|GO:0036158|GO:0036157|GO:0043623|GO:0030554|GO:0015630|GO:0009855|GO:0001578|GO:0016462|GO:0003341|GO:0007368|GO:0017111|GO:0016887|GO:0003774|GO:0003777 locomotion|developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|intracellular organelle|ion binding|cell motility|anatomical structure morphogenesis|cellular component organization|hydrolase activity|intracellular|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|heart development|axoneme|multicellular organism development|animal organ development|anion binding|microtubule|forebrain development|nucleoside binding|hydrolase activity, acting on acid anhydrides|brain development|cellular component assembly|pattern specification process|head development|sperm motility|movement of cell or subcellular component|microtubule associated complex|lateral ventricle development|nucleotide binding|cell projection organization|cellular developmental process|telencephalon development|microtubule-based process|organelle organization|cell morphogenesis|axonemal dynein complex|axonemal dynein complex assembly|purine ribonucleoside triphosphate binding|cytoskeleton organization|cardiovascular system development|central nervous system development|purine nucleoside binding|axoneme assembly|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cilium organization|ribonucleoside binding|cell projection assembly|microtubule-based movement|dynein complex|protein complex assembly|organelle assembly|cilium assembly|ventricular system development|cell part morphogenesis|nervous system development|purine nucleotide binding|cell projection morphogenesis|circulatory system development|microtubule cytoskeleton organization|cytoskeleton|cilium morphogenesis|cellular macromolecular complex assembly|ATP binding|outer dynein arm assembly|outer dynein arm|cellular protein complex assembly|adenyl nucleotide binding|microtubule cytoskeleton|determination of bilateral symmetry|microtubule bundle formation|pyrophosphatase activity|cilium movement|determination of left/right symmetry|nucleoside-triphosphatase activity|ATPase activity|motor activity|microtubule motor activity K10408 dynein heavy chain, axonemal[-] hsa05016 Huntington,s disease - Homo sapiens (human) 5:13690331-13944543 20 20 50 85 107 129 0.0823431418376229 0.074835343785658 0.185602459198064 0.313556380656006 0.361451124467422 0.497754432511592 0.114260314940448 0.39092064587834 -1.77455136877973 3.90828012672849e-06 4.31022515343008e-05 DOWN ENSG00000159792 PSKH1 protein serine kinase H1 [Source:HGNC Symbol;Acc:HGNC:9529] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0007507|GO:0007275|GO:0048513|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0007389|GO:0005783|GO:0000166|GO:0019538|GO:0005794|GO:0035639|GO:0043412|GO:0072358|GO:0005815|GO:0001883|GO:0036211|GO:0032549|GO:0031981|GO:0005654|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0072359|GO:0016773|GO:0005856|GO:0005634|GO:0005524|GO:0030554|GO:0016310|GO:0016604|GO:0015630|GO:0009855|GO:0004672|GO:0006464|GO:0016607|GO:0006468|GO:0007368|GO:0004674 developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|organelle membrane|heart development|multicellular organism development|animal organ development|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|endoplasmic reticulum|nucleotide binding|protein metabolic process|Golgi apparatus|purine ribonucleoside triphosphate binding|macromolecule modification|cardiovascular system development|microtubule organizing center|purine nucleoside binding|protein modification process|ribonucleoside binding|nuclear lumen|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|circulatory system development|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|ATP binding|adenyl nucleotide binding|phosphorylation|nuclear body|microtubule cytoskeleton|determination of bilateral symmetry|protein kinase activity|cellular protein modification process|nuclear speck|protein phosphorylation|determination of left/right symmetry|protein serine/threonine kinase activity - - - - 16:67893272-67929678 274 280 283 605 666 570 3.81909830563188 3.54688563194866 3.5563917443186 7.55548796133755 7.61643916138618 7.44583241134507 3.64079189396638 7.53925317802293 -1.05016934101045 3.91506444023424e-06 4.31611276952559e-05 DOWN ENSG00000138095 LRPPRC leucine rich pentatricopeptide repeat containing [Source:HGNC Symbol;Acc:HGNC:15714] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0019867|GO:0009058|GO:0005640|GO:0005622|GO:0005515|GO:0012505|GO:0042645|GO:0031090|GO:0019222|GO:0006725|GO:0051640|GO:0019866|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0005874|GO:0046483|GO:0051128|GO:0043231|GO:0019899|GO:0005737|GO:0030529|GO:0005635|GO:0006928|GO:0032403|GO:0051656|GO:0006139|GO:0010970|GO:0051649|GO:0008092|GO:0006403|GO:0031965|GO:0044249|GO:0007017|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0015631|GO:0032268|GO:0051646|GO:0003677|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0051252|GO:0051654|GO:0044265|GO:0008017|GO:0046907|GO:0005637|GO:0031981|GO:0007018|GO:0048471|GO:0005654|GO:0005759|GO:0005739|GO:0005694|GO:0000228|GO:0050658|GO:0043603|GO:0033043|GO:0044267|GO:0010467|GO:0019439|GO:0051246|GO:0009059|GO:0016070|GO:0072384|GO:0005856|GO:0005634|GO:0044389|GO:0032543|GO:0031625|GO:0006401|GO:0043043|GO:0048487|GO:0051028|GO:0003697|GO:0032774|GO:0000793|GO:0047497|GO:2001141|GO:0010608|GO:0000794|GO:0006412|GO:0015630|GO:0010821|GO:0006417|GO:0070129|GO:0044822|GO:0030705|GO:0006351|GO:0006355|GO:1903506|GO:0000961|GO:0000957 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|outer membrane|biosynthetic process|nuclear outer membrane|intracellular|protein binding|endomembrane system|mitochondrial nucleoid|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organelle localization|organelle inner membrane|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|microtubule|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|intracellular ribonucleoprotein complex|nuclear envelope|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|nucleobase-containing compound metabolic process|establishment of localization by movement along microtubule|establishment of localization in cell|cytoskeletal protein binding|RNA localization|nuclear membrane|cellular biosynthetic process|microtubule-based process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|tubulin binding|regulation of cellular protein metabolic process|mitochondrion localization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|regulation of RNA metabolic process|establishment of mitochondrion localization|cellular macromolecule catabolic process|microtubule binding|intracellular transport|nuclear inner membrane|nuclear lumen|microtubule-based movement|perinuclear region of cytoplasm|nucleoplasm|mitochondrial matrix|mitochondrion|chromosome|nuclear chromosome|RNA transport|cellular amide metabolic process|regulation of organelle organization|cellular protein metabolic process|gene expression|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|organelle transport along microtubule|cytoskeleton|nucleus|ubiquitin-like protein ligase binding|mitochondrial translation|ubiquitin protein ligase binding|RNA catabolic process|peptide biosynthetic process|beta-tubulin binding|mRNA transport|single-stranded DNA binding|RNA biosynthetic process|condensed chromosome|mitochondrion transport along microtubule|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|condensed nuclear chromosome|translation|microtubule cytoskeleton|regulation of mitochondrion organization|regulation of translation|regulation of mitochondrial translation|poly(A) RNA binding|cytoskeleton-dependent intracellular transport|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|negative regulation of mitochondrial RNA catabolic process|mitochondrial RNA catabolic process - - - - 2:43886508-43996005 2197 2621 3682 6083 6821 5239 12.6822991162904 13.7503861369223 19.1631070141757 31.4617873730567 32.3060503073001 28.3429573515271 15.1985974224628 30.7035983439613 -1.01446955075386 4.0087715640892e-06 4.41452844980889e-05 DOWN ENSG00000182208 MOB2 MOB kinase activator 2 [Source:HGNC Symbol;Acc:HGNC:24904] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0045595|GO:0048468|GO:0051130|GO:0007275|GO:0031325|GO:0051128|GO:0045597|GO:0043231|GO:0043169|GO:0005737|GO:0043005|GO:0044306|GO:0030030|GO:0048869|GO:0030029|GO:0019538|GO:0031323|GO:0006996|GO:0005730|GO:0032268|GO:0031175|GO:0031344|GO:0046872|GO:0043412|GO:0007010|GO:0010720|GO:0031346|GO:0036211|GO:0031981|GO:0050769|GO:0051247|GO:0048471|GO:0030036|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0007399|GO:0051246|GO:0030154|GO:0005634|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0031401|GO:0016310|GO:0022008|GO:0006464|GO:0050767|GO:0010976|GO:0045666|GO:0006468|GO:0048699|GO:0042325|GO:0001932|GO:0001934|GO:0045664|GO:0042327 developmental process|cell|cellular process|metabolic process|binding|cell projection|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cell development|positive regulation of cellular component organization|multicellular organism development|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|cytoplasm|neuron projection|neuron projection terminus|cell projection organization|cellular developmental process|actin filament-based process|protein metabolic process|regulation of cellular metabolic process|organelle organization|nucleolus|regulation of cellular protein metabolic process|neuron projection development|regulation of cell projection organization|metal ion binding|macromolecule modification|cytoskeleton organization|positive regulation of cell development|positive regulation of cell projection organization|protein modification process|nuclear lumen|positive regulation of neurogenesis|positive regulation of protein metabolic process|perinuclear region of cytoplasm|actin cytoskeleton organization|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|regulation of protein metabolic process|cell differentiation|nucleus|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|positive regulation of protein modification process|phosphorylation|neurogenesis|cellular protein modification process|regulation of neurogenesis|positive regulation of neuron projection development|positive regulation of neuron differentiation|protein phosphorylation|generation of neurons|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|regulation of neuron differentiation|positive regulation of phosphorylation - - - - 11:1469457-1501247 52 52 107 216 193 198 0.500932051770567 0.455255305476183 0.929331975046166 1.86433546719215 1.5254499321556 1.78757993599992 0.628506444097639 1.72578844511589 -1.45725618149523 4.01989196484571e-06 4.42514213563805e-05 DOWN ENSG00000134864 GGACT gamma-glutamylamine cyclotransferase [Source:HGNC Symbol;Acc:HGNC:25100] GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0005515|GO:0016740|GO:0006575|GO:0031982|GO:0016746|GO:0070062|GO:0042219|GO:0003839 cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|protein binding|transferase activity|cellular modified amino acid metabolic process|vesicle|transferase activity, transferring acyl groups|extracellular exosome|cellular modified amino acid catabolic process|gamma-glutamylcyclotransferase activity - - - - 13:100530164-100589528 13 14 32 91 60 70 0.139688508096703 0.13671915982181 0.310015329719139 0.876110158511287 0.528981087648319 0.704931841173246 0.195474332545884 0.703341029110951 -1.8472451970318 4.03802776513941e-06 4.44346778107157e-05 DOWN ENSG00000111707 SUDS3 SDS3 homolog, SIN3A corepressor complex component [Source:HGNC Symbol;Acc:HGNC:29545] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0010941|GO:0007275|GO:0016570|GO:0048513|GO:0048857|GO:0034641|GO:0046483|GO:0007420|GO:0010942|GO:0043231|GO:0019213|GO:0019899|GO:0005737|GO:0060322|GO:0016810|GO:0009890|GO:0030901|GO:0006139|GO:0000790|GO:0008219|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0043412|GO:0007417|GO:0010629|GO:0051252|GO:0006325|GO:0016811|GO:0070822|GO:0036211|GO:0021762|GO:0031981|GO:0042826|GO:0005654|GO:0005694|GO:0033558|GO:0000228|GO:0012501|GO:0044267|GO:0010467|GO:0000118|GO:0007399|GO:0009059|GO:0043068|GO:0016070|GO:0016575|GO:0005634|GO:0043067|GO:0045814|GO:0016580|GO:0043065|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0040029|GO:0042981|GO:0016568|GO:0006464|GO:0004407|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122|GO:0006476 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|histone modification|animal organ development|neural nucleus development|cellular nitrogen compound metabolic process|heterocycle metabolic process|brain development|positive regulation of cell death|intracellular membrane-bounded organelle|deacetylase activity|enzyme binding|cytoplasm|head development|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|negative regulation of biosynthetic process|midbrain development|nucleobase-containing compound metabolic process|nuclear chromatin|cell death|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|central nervous system development|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|Sin3-type complex|protein modification process|substantia nigra development|nuclear lumen|histone deacetylase binding|nucleoplasm|chromosome|protein deacetylase activity|nuclear chromosome|programmed cell death|cellular protein metabolic process|gene expression|histone deacetylase complex|nervous system development|macromolecule biosynthetic process|positive regulation of programmed cell death|RNA metabolic process|histone deacetylation|nucleus|regulation of programmed cell death|negative regulation of gene expression, epigenetic|Sin3 complex|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|regulation of apoptotic process|chromatin modification|cellular protein modification process|histone deacetylase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter|protein deacetylation - - - - 12:118376380-118418031 645 760 1204 1777 1863 2149 7.30589296755895 7.82360455234725 12.2957201206455 18.0342610166099 17.3138705438679 22.8128067368004 9.14173921351723 19.3869794324261 -1.08454747453102 4.07073467288129e-06 4.47780814016942e-05 DOWN ENSG00000052126 PLEKHA5 pleckstrin homology domain containing A5 [Source:HGNC Symbol;Acc:HGNC:30036] GO:0032502|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0048856|GO:0007275|GO:0043168|GO:0005543|GO:0043231|GO:0005737|GO:0005829|GO:0061458|GO:0035091|GO:0031981|GO:0005654|GO:0005634|GO:0005545|GO:1901981|GO:1902936|GO:0070273|GO:0032266|GO:0010314|GO:0080025 developmental process|cell|membrane|binding|intracellular organelle|ion binding|membrane-bounded organelle|lipid binding|intracellular|protein binding|anatomical structure development|multicellular organism development|anion binding|phospholipid binding|intracellular membrane-bounded organelle|cytoplasm|cytosol|reproductive system development|phosphatidylinositol binding|nuclear lumen|nucleoplasm|nucleus|1-phosphatidylinositol binding|phosphatidylinositol phosphate binding|phosphatidylinositol bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|phosphatidylinositol-3,5-bisphosphate binding - - - - 12:19129752-19376400 171 222 289 470 554 528 0.818348046965825 0.965549087446954 1.24696275044971 2.01528819659154 2.17530187939491 2.36812432162642 1.0102866282875 2.18623813253762 -1.11368589497671 4.07261561909192e-06 4.47822713415728e-05 DOWN ENSG00000096093 EFHC1 EF-hand domain (C-terminal) containing 1 [Source:HGNC Symbol;Acc:HGNC:16406] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0043229|GO:0043167|GO:0048870|GO:0044297|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0008022|GO:0043025|GO:0005930|GO:0007275|GO:0048513|GO:0030900|GO:0007420|GO:0043169|GO:0060322|GO:0021987|GO:0006928|GO:0036477|GO:0016477|GO:0021543|GO:0021537|GO:0022029|GO:0005813|GO:0046872|GO:0007417|GO:0005815|GO:0021885|GO:0021795|GO:0007399|GO:0005856|GO:0005819|GO:0072686|GO:0005509|GO:0015630 locomotion|developmental process|cell|cellular process|binding|cell projection|intracellular organelle|ion binding|cell motility|cell body|intracellular|protein binding|anatomical structure development|cilium|protein C-terminus binding|neuronal cell body|axoneme|multicellular organism development|animal organ development|forebrain development|brain development|cation binding|head development|cerebral cortex development|movement of cell or subcellular component|somatodendritic compartment|cell migration|pallium development|telencephalon development|telencephalon cell migration|centrosome|metal ion binding|central nervous system development|microtubule organizing center|forebrain cell migration|cerebral cortex cell migration|nervous system development|cytoskeleton|spindle|mitotic spindle|calcium ion binding|microtubule cytoskeleton - - - - 6:52420308-52495785 52 32 125 210 258 354 0.309312483699233 0.172989712960833 0.670368557042643 1.11920032122023 1.25915415800802 1.97343723236033 0.38422358456757 1.45059723719619 -1.91662902334438 4.16546789056355e-06 4.57527146449169e-05 DOWN ENSG00000141665 FBXO15 F-box protein 15 [Source:HGNC Symbol;Acc:HGNC:13617] GO:0005488|GO:0005515 binding|protein binding - - - - 18:74073353-74147865 22 15 41 84 87 93 0.157654203810002 0.09769425142781 0.264897174484312 0.53933737861797 0.511527929143876 0.624592240338588 0.173415209907375 0.558485849366811 -1.68729028683435 4.1751266288742e-06 4.58419383517507e-05 DOWN ENSG00000146707 POMZP3 POM121 and ZP3 fusion [Source:HGNC Symbol;Acc:HGNC:9203] - - - - - - 7:76609986-76627261 312 303 152 105 102 80 5.74586450248919 5.07135718683049 2.5238211169189 1.73256055974368 1.54123714507964 1.38075872975034 4.44701426874619 1.55151881152455 1.51915584469242 4.18676573946264e-06 4.59528324948227e-05 UP ENSG00000261670 RP11-1C8.5 - - - - - - - 8:103464389-103468985 4 9 8 0 0 0 0.0615475857717338 0.125868206084293 0.110990736561607 0 0 0 0.0994688428058779 0 Inf 4.20181411641572e-06 4.61010505812109e-05 UP ENSG00000050393 MCUR1 mitochondrial calcium uniporter regulator 1 [Source:HGNC Symbol;Acc:HGNC:21097] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0031090|GO:0019866|GO:0006810|GO:0043231|GO:0005737|GO:0042592|GO:0031966|GO:0019725|GO:0051649|GO:0016021|GO:0031301|GO:0005740|GO:0048878|GO:0046907|GO:0006811|GO:0055082|GO:0005743|GO:0031304|GO:0005739|GO:0032592|GO:0006839|GO:0006812|GO:0031305|GO:0050801|GO:0006873|GO:0006851|GO:0030001|GO:0030003|GO:0055065|GO:0006875|GO:0006874|GO:0006816|GO:0055074|GO:0051560|GO:0070509|GO:0051561 cell|membrane|cellular process|binding|intracellular organelle|cellular localization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|organelle membrane|organelle inner membrane|transport|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|mitochondrial membrane|cellular homeostasis|establishment of localization in cell|integral component of membrane|integral component of organelle membrane|mitochondrial envelope|chemical homeostasis|intracellular transport|ion transport|cellular chemical homeostasis|mitochondrial inner membrane|intrinsic component of mitochondrial inner membrane|mitochondrion|integral component of mitochondrial membrane|mitochondrial transport|cation transport|integral component of mitochondrial inner membrane|ion homeostasis|cellular ion homeostasis|mitochondrial calcium ion transport|metal ion transport|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|mitochondrial calcium ion homeostasis|calcium ion import|positive regulation of mitochondrial calcium ion concentration - - - - 6:13786557-13814568 557 633 550 1265 1491 1069 6.08688656546001 6.28671290602639 5.41897020257069 12.3859189747619 13.3685926619659 10.9483001574743 5.93085655801903 12.2342705980674 -1.04461570640761 4.21131537814939e-06 4.61883208300043e-05 DOWN ENSG00000267127 RP11-795F19.5 - - - - - - - 18:80034346-80097088 15 12 14 0 2 4 0.219313058019207 0.159455896020842 0.184558232317898 0 0.0239909743323215 0.0548042541361869 0.187775728785982 0.0262650761561695 2.83779292474287 4.36741292300812e-06 4.78300606762599e-05 UP ENSG00000063854 HAGH hydroxyacylglutathione hydrolase [Source:HGNC Symbol;Acc:HGNC:4805] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0006575|GO:0006081|GO:0006082|GO:0034641|GO:0016788|GO:0044281|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0070062|GO:0042180|GO:0044249|GO:0006790|GO:0005829|GO:0006518|GO:0046872|GO:0009438|GO:0016790|GO:0006749|GO:0005759|GO:0005739|GO:0006089|GO:0042182|GO:0043603|GO:0046185|GO:0004416|GO:0043043|GO:0019752|GO:0006750|GO:0019243|GO:0032787|GO:0006090 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|cellular modified amino acid metabolic process|cellular aldehyde metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|extracellular exosome|cellular ketone metabolic process|cellular biosynthetic process|sulfur compound metabolic process|cytosol|peptide metabolic process|metal ion binding|methylglyoxal metabolic process|thiolester hydrolase activity|glutathione metabolic process|mitochondrial matrix|mitochondrion|lactate metabolic process|ketone catabolic process|cellular amide metabolic process|aldehyde catabolic process|hydroxyacylglutathione hydrolase activity|peptide biosynthetic process|carboxylic acid metabolic process|glutathione biosynthetic process|methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione|monocarboxylic acid metabolic process|pyruvate metabolic process K01069 hydroxyacylglutathione hydrolase[3.1.2.6] hsa00620 Pyruvate metabolism - Homo sapiens (human) 16:1795620-1827194 193 177 264 478 495 472 1.44498381964547 1.20436948482781 1.78206376890942 3.20650102187492 3.04074066542461 3.31189889461319 1.4771390244609 3.18638019397091 -1.1091128021051 4.38834239770324e-06 4.80416479431729e-05 DOWN ENSG00000153774 CFDP1 craniofacial development protein 1 [Source:HGNC Symbol;Acc:HGNC:1873] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0007155|GO:0050793|GO:0005622|GO:0043234|GO:0048856|GO:0042127|GO:0008360|GO:0010941|GO:0007275|GO:0000776|GO:0051128|GO:0060548|GO:0008219|GO:0048869|GO:0000902|GO:0043069|GO:0022604|GO:0005694|GO:0012501|GO:0000777|GO:0043067|GO:0000793|GO:0042981|GO:0043066|GO:0006915|GO:0000775|GO:0044346|GO:0000779|GO:2000269|GO:2000270 developmental process|macromolecular complex|cell|cellular process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|cell adhesion|regulation of developmental process|intracellular|protein complex|anatomical structure development|regulation of cell proliferation|regulation of cell shape|regulation of cell death|multicellular organism development|kinetochore|regulation of cellular component organization|negative regulation of cell death|cell death|cellular developmental process|cell morphogenesis|negative regulation of programmed cell death|regulation of cell morphogenesis|chromosome|programmed cell death|condensed chromosome kinetochore|regulation of programmed cell death|condensed chromosome|regulation of apoptotic process|negative regulation of apoptotic process|apoptotic process|chromosome, centromeric region|fibroblast apoptotic process|condensed chromosome, centromeric region|regulation of fibroblast apoptotic process|negative regulation of fibroblast apoptotic process - - - - 16:75293698-75433485 292 357 530 839 837 898 3.69765987005885 4.10859242156922 6.0511098871571 9.51929324853259 8.69637301846368 10.6573709496479 4.61912072626172 9.62434573888139 -1.05907021665952 4.41739263299339e-06 4.83108345683781e-05 DOWN ENSG00000169242 EFNA1 ephrin-A1 [Source:HGNC Symbol;Acc:HGNC:3221] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0040012|GO:0006807|GO:0071704|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0031225|GO:0048514|GO:0007507|GO:0003179|GO:0010719|GO:0006935|GO:0045595|GO:0003188|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0001568|GO:0034446|GO:0007275|GO:0010632|GO:0045596|GO:0048513|GO:0005102|GO:0016358|GO:0034641|GO:0030155|GO:0046658|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0005887|GO:0014028|GO:0007267|GO:0033627|GO:0003170|GO:0006928|GO:0009887|GO:0031589|GO:0009966|GO:0048598|GO:0048568|GO:0009890|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0001525|GO:0007154|GO:0060996|GO:0051270|GO:0016477|GO:0007165|GO:0070062|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0050768|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0060998|GO:0031175|GO:2000171|GO:0031344|GO:0010468|GO:0090132|GO:0034645|GO:0007166|GO:2000736|GO:0060997|GO:0001944|GO:0043412|GO:0072358|GO:0050773|GO:0003180|GO:0010629|GO:0097061|GO:0048813|GO:0051252|GO:0010717|GO:0003007|GO:0010721|GO:0000904|GO:0009790|GO:0003199|GO:0030334|GO:0003181|GO:0001667|GO:0051347|GO:0036211|GO:0030903|GO:0033628|GO:0031345|GO:0060485|GO:0045765|GO:0051247|GO:0022604|GO:0046875|GO:0003171|GO:0003176|GO:0032270|GO:0006796|GO:1901342|GO:0035556|GO:0044267|GO:0051174|GO:0048864|GO:0010467|GO:0032990|GO:0048562|GO:0007399|GO:0061000|GO:0097485|GO:2000737|GO:0010594|GO:0051246|GO:0009059|GO:0030154|GO:0048858|GO:1902531|GO:0016070|GO:0072359|GO:0051960|GO:0048666|GO:0003174|GO:0030182|GO:0007411|GO:0048863|GO:0010975|GO:0060317|GO:0031401|GO:0043408|GO:0010769|GO:0045892|GO:0032774|GO:0048570|GO:2001141|GO:0014031|GO:0043535|GO:0016310|GO:1902679|GO:0061564|GO:0007167|GO:0048814|GO:0043410|GO:0010631|GO:0048762|GO:0050774|GO:0045665|GO:0022008|GO:0061002|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0001837|GO:0010977|GO:0061001|GO:0043549|GO:0003183|GO:0006351|GO:0006355|GO:0033674|GO:0006366|GO:0045859|GO:1903507|GO:0045860|GO:0043406|GO:0006357|GO:0007409|GO:0090500|GO:0006468|GO:0048699|GO:1903506|GO:0043405|GO:0042325|GO:0001932|GO:0018193|GO:0001934|GO:0000122|GO:0043542|GO:0050770|GO:0045664|GO:0042327|GO:0007169|GO:0050731|GO:0050730|GO:0000187|GO:0048013|GO:0071902|GO:0071900|GO:0032147|GO:0018108|GO:0043534 locomotion|developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|anchored component of membrane|blood vessel morphogenesis|heart development|heart valve morphogenesis|negative regulation of epithelial to mesenchymal transition|chemotaxis|regulation of cell differentiation|heart valve formation|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|blood vessel development|substrate adhesion-dependent cell spreading|multicellular organism development|regulation of epithelial cell migration|negative regulation of cell differentiation|animal organ development|receptor binding|dendrite development|cellular nitrogen compound metabolic process|regulation of cell adhesion|anchored component of plasma membrane|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|integral component of plasma membrane|notochord formation|cell-cell signaling|cell adhesion mediated by integrin|heart valve development|movement of cell or subcellular component|organ morphogenesis|cell-substrate adhesion|regulation of signal transduction|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|angiogenesis|cell communication|dendritic spine development|regulation of cellular component movement|cell migration|signal transduction|extracellular exosome|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of neurogenesis|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|neuron projection development|negative regulation of dendrite development|regulation of cell projection organization|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|regulation of stem cell differentiation|dendritic spine morphogenesis|vasculature development|macromolecule modification|cardiovascular system development|regulation of dendrite development|aortic valve morphogenesis|negative regulation of gene expression|dendritic spine organization|dendrite morphogenesis|regulation of RNA metabolic process|regulation of epithelial to mesenchymal transition|heart morphogenesis|negative regulation of cell development|cell morphogenesis involved in differentiation|embryo development|endocardial cushion to mesenchymal transition involved in heart valve formation|regulation of cell migration|atrioventricular valve morphogenesis|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|notochord development|regulation of cell adhesion mediated by integrin|negative regulation of cell projection organization|mesenchyme development|regulation of angiogenesis|positive regulation of protein metabolic process|regulation of cell morphogenesis|ephrin receptor binding|atrioventricular valve development|aortic valve development|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|gene expression|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|negative regulation of dendritic spine development|neuron projection guidance|negative regulation of stem cell differentiation|regulation of endothelial cell migration|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|regulation of nervous system development|neuron development|mitral valve development|neuron differentiation|axon guidance|stem cell differentiation|regulation of neuron projection development|cardiac epithelial to mesenchymal transition|positive regulation of protein modification process|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|notochord morphogenesis|regulation of RNA biosynthetic process|mesenchymal cell development|regulation of blood vessel endothelial cell migration|phosphorylation|negative regulation of RNA biosynthetic process|axon development|enzyme linked receptor protein signaling pathway|regulation of dendrite morphogenesis|positive regulation of MAPK cascade|epithelial cell migration|mesenchymal cell differentiation|negative regulation of dendrite morphogenesis|negative regulation of neuron differentiation|neurogenesis|negative regulation of dendritic spine morphogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|epithelial to mesenchymal transition|negative regulation of neuron projection development|regulation of dendritic spine morphogenesis|regulation of kinase activity|mitral valve morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of kinase activity|transcription from RNA polymerase II promoter|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of transcription from RNA polymerase II promoter|axonogenesis|endocardial cushion to mesenchymal transition|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|endothelial cell migration|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|activation of MAPK activity|ephrin receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|peptidyl-tyrosine phosphorylation|blood vessel endothelial cell migration K05462 ephrin-A[-] hsa04151|hsa04014|hsa04015|hsa04360 PI3K-Akt signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Axon guidance - Homo sapiens (human) 1:155127460-155134857 715 741 1452 442 481 533 11.5366901851332 10.8660999348914 21.1230220252038 6.38991219868619 6.36778771643347 8.05993267372241 14.5086040484095 6.93921086294736 1.06406520467036 4.4177858367948e-06 4.83108345683781e-05 UP ENSG00000249395 CASC9 cancer susceptibility candidate 9 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:48906] - - - - - - 8:75223404-75324741 2 1 3 19 15 16 0.0430645740932512 0.0195792166626908 0.0582346367772516 0.366576602868748 0.265022735364288 0.322895878095675 0.0402928091777312 0.31816507210957 -2.98118116904795 4.4272874283571e-06 4.839701167564e-05 DOWN ENSG00000171132 PRKCE protein kinase C, epsilon [Source:HGNC Symbol;Acc:HGNC:9401] GO:0040011|GO:0004871|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0051050|GO:0006950|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0007626|GO:0019222|GO:0060341|GO:0044262|GO:0051272|GO:0002757|GO:0051726|GO:0007049|GO:0051282|GO:0050817|GO:0050804|GO:0045087|GO:0046887|GO:0006810|GO:0022402|GO:0051130|GO:0006082|GO:0061178|GO:0010632|GO:0002281|GO:0051302|GO:0032535|GO:0043168|GO:0008047|GO:0044281|GO:0032940|GO:0006952|GO:0030155|GO:0035641|GO:0001882|GO:0016772|GO:0031325|GO:0051128|GO:2000147|GO:0033554|GO:0050806|GO:0022607|GO:0035640|GO:0043231|GO:0043178|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0032970|GO:0002218|GO:0007267|GO:0009611|GO:0032880|GO:0071889|GO:0005975|GO:0051222|GO:0006928|GO:0042592|GO:0070255|GO:0001775|GO:0031589|GO:0070257|GO:0009966|GO:0002263|GO:0045184|GO:0046883|GO:0019725|GO:0045787|GO:0010646|GO:0043085|GO:0009617|GO:0050776|GO:0008104|GO:0007154|GO:0044092|GO:0055085|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0002366|GO:0050778|GO:0005783|GO:0042180|GO:0051649|GO:0045785|GO:0008092|GO:2000021|GO:0009725|GO:0008219|GO:0010634|GO:0001666|GO:0030546|GO:0051047|GO:0050790|GO:0000166|GO:0032410|GO:0051781|GO:0051238|GO:0051301|GO:0010817|GO:0030029|GO:2000145|GO:0009967|GO:0010469|GO:0019538|GO:0031334|GO:0043254|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0050878|GO:0034763|GO:0043271|GO:0005794|GO:0006996|GO:0071774|GO:0032467|GO:0000165|GO:0016192|GO:1902533|GO:0032268|GO:0006109|GO:0006909|GO:0005829|GO:0009743|GO:0090132|GO:0030168|GO:0090068|GO:0046872|GO:0007166|GO:0032956|GO:0090276|GO:0033993|GO:0035639|GO:0002793|GO:0043412|GO:0007010|GO:0007589|GO:0002758|GO:0051345|GO:0002237|GO:0016042|GO:0050996|GO:0048878|GO:0007596|GO:0032386|GO:0001883|GO:0003779|GO:0051223|GO:0015031|GO:0051208|GO:0030334|GO:0050994|GO:0001667|GO:0036211|GO:0032269|GO:0071456|GO:0070201|GO:0042060|GO:0071219|GO:0046907|GO:0042886|GO:0006811|GO:0051209|GO:0032549|GO:0055082|GO:0050714|GO:0002429|GO:0032413|GO:0051279|GO:0032465|GO:0051046|GO:0010766|GO:0043279|GO:0007599|GO:0044344|GO:0010564|GO:0009914|GO:0009306|GO:0005996|GO:0034766|GO:0070254|GO:0010810|GO:0051247|GO:0048471|GO:0070848|GO:0034765|GO:0005739|GO:0002764|GO:0006461|GO:0016301|GO:0042116|GO:0030036|GO:0071453|GO:0043269|GO:0010565|GO:0070542|GO:0035773|GO:0032270|GO:0032230|GO:0012501|GO:0014070|GO:0006796|GO:0035556|GO:0032273|GO:0060359|GO:0033043|GO:0044267|GO:0051174|GO:0019216|GO:0046903|GO:0071310|GO:0017076|GO:0051246|GO:0010522|GO:0010811|GO:0030832|GO:0030335|GO:1902531|GO:0016773|GO:0032870|GO:0005856|GO:0000910|GO:0032496|GO:0005634|GO:0090303|GO:0038096|GO:0032228|GO:0045089|GO:0097305|GO:0022898|GO:0035276|GO:0045088|GO:2000273|GO:0034220|GO:0090277|GO:0010638|GO:0050796|GO:0071322|GO:0002790|GO:0071398|GO:0030073|GO:0098655|GO:0031401|GO:0001678|GO:0043122|GO:0008543|GO:0003785|GO:0034622|GO:2001031|GO:0030838|GO:0043408|GO:0005524|GO:0010763|GO:0006812|GO:0043623|GO:0034284|GO:0050708|GO:0071363|GO:0030554|GO:2000650|GO:0016310|GO:0015833|GO:0002768|GO:0038179|GO:0060402|GO:0002221|GO:0008064|GO:0016482|GO:0032412|GO:0045471|GO:0051493|GO:0007167|GO:0043123|GO:0032024|GO:0007249|GO:0043278|GO:0010762|GO:0034695|GO:0043410|GO:0010631|GO:0050801|GO:0004672|GO:0019752|GO:0002431|GO:0006897|GO:0006464|GO:0071379|GO:0007015|GO:0051495|GO:1902306|GO:0071396|GO:0046879|GO:0010761|GO:0030833|GO:0060193|GO:0006915|GO:0006873|GO:0090279|GO:0033500|GO:0071222|GO:0061041|GO:0036294|GO:0031663|GO:0048011|GO:0071333|GO:0042593|GO:0051258|GO:1903169|GO:0030072|GO:0002224|GO:0010517|GO:0006468|GO:0042325|GO:0001932|GO:0071361|GO:0018193|GO:0038093|GO:0004674|GO:0002028|GO:0032787|GO:1902305|GO:0030001|GO:0001934|GO:2000649|GO:0051924|GO:0010518|GO:0071380|GO:0030003|GO:0015672|GO:0042327|GO:0007268|GO:0007169|GO:0008154|GO:0032446|GO:0010863|GO:0035725|GO:0038094|GO:0070588|GO:0050730|GO:0052695|GO:0007270|GO:0006814|GO:0055065|GO:0002756|GO:0031396|GO:0031397|GO:0097553|GO:0006875|GO:0009749|GO:0018105|GO:0034142|GO:0030041|GO:0004697|GO:0038127|GO:0018108|GO:0007173|GO:0051932|GO:0006874|GO:0006816|GO:0035669|GO:0004699|GO:0007202|GO:0055074|GO:0016567|GO:0051480|GO:0070509|GO:0060401|GO:0007204 locomotion|signal transducer activity|immune system process|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|positive regulation of transport|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|transferase activity|locomotory behavior|regulation of metabolic process|regulation of cellular localization|cellular carbohydrate metabolic process|positive regulation of cellular component movement|immune response-activating signal transduction|regulation of cell cycle|cell cycle|regulation of sequestering of calcium ion|coagulation|modulation of synaptic transmission|innate immune response|positive regulation of hormone secretion|transport|cell cycle process|positive regulation of cellular component organization|organic acid metabolic process|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of epithelial cell migration|macrophage activation involved in immune response|regulation of cell division|regulation of cellular component size|anion binding|enzyme activator activity|small molecule metabolic process|secretion by cell|defense response|regulation of cell adhesion|locomotory exploration behavior|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|positive regulation of synaptic transmission|cellular component assembly|exploration behavior|intracellular membrane-bounded organelle|alcohol binding|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|activation of innate immune response|cell-cell signaling|response to wounding|regulation of protein localization|14-3-3 protein binding|carbohydrate metabolic process|positive regulation of protein transport|movement of cell or subcellular component|homeostatic process|regulation of mucus secretion|cell activation|cell-substrate adhesion|positive regulation of mucus secretion|regulation of signal transduction|cell activation involved in immune response|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|positive regulation of cell cycle|regulation of cell communication|positive regulation of catalytic activity|response to bacterium|regulation of immune response|protein localization|cell communication|negative regulation of molecular function|transmembrane transport|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|endoplasmic reticulum|cellular ketone metabolic process|establishment of localization in cell|positive regulation of cell adhesion|cytoskeletal protein binding|regulation of ion homeostasis|response to hormone|cell death|positive regulation of epithelial cell migration|response to hypoxia|receptor activator activity|positive regulation of secretion|regulation of catalytic activity|nucleotide binding|negative regulation of transporter activity|positive regulation of cell division|sequestering of metal ion|cell division|regulation of hormone levels|actin filament-based process|regulation of cell motility|positive regulation of signal transduction|regulation of receptor activity|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|negative regulation of transmembrane transport|negative regulation of ion transport|Golgi apparatus|organelle organization|response to fibroblast growth factor|positive regulation of cytokinesis|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|phagocytosis|cytosol|response to carbohydrate|epithelium migration|platelet activation|positive regulation of cell cycle process|metal ion binding|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|regulation of peptide hormone secretion|response to lipid|purine ribonucleoside triphosphate binding|positive regulation of peptide secretion|macromolecule modification|cytoskeleton organization|body fluid secretion|innate immune response-activating signal transduction|positive regulation of hydrolase activity|response to molecule of bacterial origin|lipid catabolic process|positive regulation of lipid catabolic process|chemical homeostasis|blood coagulation|regulation of intracellular transport|purine nucleoside binding|actin binding|regulation of protein transport|protein transport|sequestering of calcium ion|regulation of cell migration|regulation of lipid catabolic process|ameboidal-type cell migration|protein modification process|negative regulation of cellular protein metabolic process|cellular response to hypoxia|regulation of establishment of protein localization|wound healing|cellular response to molecule of bacterial origin|intracellular transport|amide transport|ion transport|release of sequestered calcium ion into cytosol|ribonucleoside binding|cellular chemical homeostasis|positive regulation of protein secretion|immune response-activating cell surface receptor signaling pathway|negative regulation of ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol|regulation of cytokinesis|regulation of secretion|negative regulation of sodium ion transport|response to alkaloid|hemostasis|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|hormone transport|protein secretion|monosaccharide metabolic process|negative regulation of ion transmembrane transport|mucus secretion|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|perinuclear region of cytoplasm|response to growth factor|regulation of ion transmembrane transport|mitochondrion|immune response-regulating signaling pathway|protein complex assembly|kinase activity|macrophage activation|actin cytoskeleton organization|cellular response to oxygen levels|regulation of ion transport|regulation of cellular ketone metabolic process|response to fatty acid|insulin secretion involved in cellular response to glucose stimulus|positive regulation of cellular protein metabolic process|positive regulation of synaptic transmission, GABAergic|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|positive regulation of protein polymerization|response to ammonium ion|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of lipid metabolic process|secretion|cellular response to organic substance|purine nucleotide binding|regulation of protein metabolic process|regulation of calcium ion transport into cytosol|positive regulation of cell-substrate adhesion|regulation of actin filament length|positive regulation of cell migration|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|cytoskeleton|cytokinesis|response to lipopolysaccharide|nucleus|positive regulation of wound healing|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of synaptic transmission, GABAergic|positive regulation of innate immune response|response to alcohol|regulation of transmembrane transporter activity|ethanol binding|regulation of innate immune response|positive regulation of receptor activity|ion transmembrane transport|positive regulation of peptide hormone secretion|positive regulation of organelle organization|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|cellular response to fatty acid|insulin secretion|cation transmembrane transport|positive regulation of protein modification process|cellular glucose homeostasis|regulation of I-kappaB kinase/NF-kappaB signaling|fibroblast growth factor receptor signaling pathway|actin monomer binding|cellular macromolecular complex assembly|positive regulation of cellular glucuronidation|positive regulation of actin filament polymerization|regulation of MAPK cascade|ATP binding|positive regulation of fibroblast migration|cation transport|cellular protein complex assembly|response to monosaccharide|regulation of protein secretion|cellular response to growth factor stimulus|adenyl nucleotide binding|negative regulation of sodium ion transmembrane transporter activity|phosphorylation|peptide transport|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|calcium ion transport into cytosol|pattern recognition receptor signaling pathway|regulation of actin polymerization or depolymerization|cytosolic transport|regulation of ion transmembrane transporter activity|response to ethanol|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of insulin secretion|I-kappaB kinase/NF-kappaB signaling|response to morphine|regulation of fibroblast migration|response to prostaglandin E|positive regulation of MAPK cascade|epithelial cell migration|ion homeostasis|protein kinase activity|carboxylic acid metabolic process|Fc receptor mediated stimulatory signaling pathway|endocytosis|cellular protein modification process|cellular response to prostaglandin stimulus|actin filament organization|positive regulation of cytoskeleton organization|negative regulation of sodium ion transmembrane transport|cellular response to lipid|hormone secretion|fibroblast migration|regulation of actin filament polymerization|positive regulation of lipase activity|apoptotic process|cellular ion homeostasis|regulation of calcium ion import|carbohydrate homeostasis|cellular response to lipopolysaccharide|regulation of wound healing|cellular response to decreased oxygen levels|lipopolysaccharide-mediated signaling pathway|neurotrophin TRK receptor signaling pathway|cellular response to glucose stimulus|glucose homeostasis|protein polymerization|regulation of calcium ion transmembrane transport|peptide hormone secretion|toll-like receptor signaling pathway|regulation of phospholipase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to ethanol|peptidyl-amino acid modification|Fc receptor signaling pathway|protein serine/threonine kinase activity|regulation of sodium ion transport|monocarboxylic acid metabolic process|regulation of sodium ion transmembrane transport|metal ion transport|positive regulation of protein phosphorylation|regulation of sodium ion transmembrane transporter activity|regulation of calcium ion transport|positive regulation of phospholipase activity|cellular response to prostaglandin E stimulus|cellular cation homeostasis|monovalent inorganic cation transport|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|actin polymerization or depolymerization|protein modification by small protein conjugation|positive regulation of phospholipase C activity|sodium ion transmembrane transport|Fc-gamma receptor signaling pathway|calcium ion transmembrane transport|regulation of peptidyl-tyrosine phosphorylation|cellular glucuronidation|neuron-neuron synaptic transmission|sodium ion transport|metal ion homeostasis|MyD88-independent toll-like receptor signaling pathway|regulation of protein ubiquitination|negative regulation of protein ubiquitination|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|response to glucose|peptidyl-serine phosphorylation|toll-like receptor 4 signaling pathway|actin filament polymerization|protein kinase C activity|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|epidermal growth factor receptor signaling pathway|synaptic transmission, GABAergic|cellular calcium ion homeostasis|calcium ion transport|TRAM-dependent toll-like receptor 4 signaling pathway|calcium-independent protein kinase C activity|activation of phospholipase C activity|calcium ion homeostasis|protein ubiquitination|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K18050 novel protein kinase C epsilon type[2.7.11.13] hsa05206|hsa04022|hsa04530|hsa04270|hsa04071|hsa04931|hsa04933|hsa04750|hsa04666|hsa04925|hsa04930 MicroRNAs in cancer - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Type II diabetes mellitus - Homo sapiens (human) 2:45651345-46187990 40 52 115 187 224 253 0.237571371941595 0.280683434770077 0.61581100829032 0.995113574231721 1.09156382939114 1.40826272737823 0.378021938333997 1.16498004366703 -1.6237633732972 4.52935268872148e-06 4.94584108153223e-05 DOWN ENSG00000036054 TBC1D23 TBC1 domain family member 23 [Source:HGNC Symbol;Acc:HGNC:25622] GO:0050896|GO:0005488|GO:0006950|GO:0009605|GO:0005515|GO:0006952|GO:0001817|GO:0001816|GO:0009611|GO:0001819|GO:0032675|GO:0032635|GO:0050727|GO:0032755|GO:0006954|GO:0032680|GO:0032640 response to stimulus|binding|response to stress|response to external stimulus|protein binding|defense response|regulation of cytokine production|cytokine production|response to wounding|positive regulation of cytokine production|regulation of interleukin-6 production|interleukin-6 production|regulation of inflammatory response|positive regulation of interleukin-6 production|inflammatory response|regulation of tumor necrosis factor production|tumor necrosis factor production - - - - 3:100261000-100325251 559 594 1070 1488 1727 1870 4.0874388943683 3.94735562169558 7.05403281279021 9.74855310816289 10.3609565467461 12.814753779013 5.02960910961803 10.974754477974 -1.12567047847889 4.59694638147603e-06 5.01781489113657e-05 DOWN ENSG00000225137 DYNC1I2P1 dynein, cytoplasmic 1, intermediate chain 2 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:45012] - - - - - - 10:50264978-50266815 241 255 275 522 620 540 9.27505477226338 8.91909273929303 9.54218195581987 17.9998449679885 19.5776293265143 19.4770487355786 9.24544315579209 19.0181743433605 -1.0405643826452 4.6496307578362e-06 5.069761747423e-05 DOWN ENSG00000144847 IGSF11 immunoglobulin superfamily member 11 [Source:HGNC Symbol;Acc:HGNC:16669] GO:0040007|GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0007155|GO:0043227|GO:0071944|GO:0040008|GO:0031224|GO:0005515|GO:0005886|GO:0031982|GO:0070062|GO:0016021 growth|cell|membrane|extracellular region|binding|extracellular vesicle|cell adhesion|membrane-bounded organelle|cell periphery|regulation of growth|intrinsic component of membrane|protein binding|plasma membrane|vesicle|extracellular exosome|integral component of membrane - - - - 3:118900557-119146068 0 1 0 8 9 10 0 0.00421203187537258 0 0.0332054237625853 0.0342067166249796 0.0434137505257094 0.00140401062512419 0.0369419636377581 -4.71763479565986 4.67092534432619e-06 5.09112103795232e-05 DOWN ENSG00000081320 STK17B serine/threonine kinase 17b [Source:HGNC Symbol;Acc:HGNC:11396] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0010941|GO:0043168|GO:0001882|GO:0016772|GO:0010942|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0008219|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0005793|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0043068|GO:0016773|GO:0005856|GO:0005634|GO:0043067|GO:0015629|GO:0043065|GO:0005524|GO:0030554|GO:0016310|GO:0042981|GO:0004672|GO:0006464|GO:0006915|GO:0044346|GO:2000269|GO:0006468|GO:0004674|GO:2000271|GO:0046777 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|transferase activity|regulation of cell death|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|cell death|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|positive regulation of programmed cell death|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|regulation of programmed cell death|actin cytoskeleton|positive regulation of apoptotic process|ATP binding|adenyl nucleotide binding|phosphorylation|regulation of apoptotic process|protein kinase activity|cellular protein modification process|apoptotic process|fibroblast apoptotic process|regulation of fibroblast apoptotic process|protein phosphorylation|protein serine/threonine kinase activity|positive regulation of fibroblast apoptotic process|protein autophosphorylation - - - - 2:196133566-196176503 684 685 1125 340 467 504 6.61164388204529 6.01760485772348 9.80438274345107 2.94462757392611 3.70372299682386 4.56575241304231 7.47787716107328 3.73803432793076 1.0003489542553 4.70279874554792e-06 5.12399101275867e-05 UP ENSG00000151093 OXSM 3-oxoacyl-ACP synthase, mitochondrial [Source:HGNC Symbol;Acc:HGNC:26063] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0016740|GO:0044255|GO:0006082|GO:0044281|GO:0043231|GO:0016746|GO:0005737|GO:0051186|GO:0006629|GO:0044249|GO:0006790|GO:0006637|GO:0006631|GO:0005739|GO:0016747|GO:0008610|GO:0004312|GO:0046459|GO:0051791|GO:0006633|GO:0019752|GO:0051792|GO:0032787|GO:0004315|GO:0051790 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|transferase activity|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|cofactor metabolic process|lipid metabolic process|cellular biosynthetic process|sulfur compound metabolic process|acyl-CoA metabolic process|fatty acid metabolic process|mitochondrion|transferase activity, transferring acyl groups other than amino-acyl groups|lipid biosynthetic process|fatty acid synthase activity|short-chain fatty acid metabolic process|medium-chain fatty acid metabolic process|fatty acid biosynthetic process|carboxylic acid metabolic process|medium-chain fatty acid biosynthetic process|monocarboxylic acid metabolic process|3-oxoacyl-[acyl-carrier-protein] synthase activity|short-chain fatty acid biosynthetic process K09458 3-oxoacyl-[acyl-carrier-protein] synthase II[2.3.1.179] hsa01100|hsa01212|hsa00061|hsa00780 Metabolic pathways - Homo sapiens (human)|Fatty acid metabolism - Homo sapiens (human)|Fatty acid biosynthesis - Homo sapiens (human)|Biotin metabolism - Homo sapiens (human) 3:25782917-25794534 347 386 310 169 211 133 3.70725055272904 3.74791715025473 2.98605378827236 1.61773318839885 1.84957740183438 1.33169195034631 3.48040716375204 1.59966751352651 1.12148401698315 4.71348317495752e-06 5.13375872693112e-05 UP ENSG00000147862 NFIB nuclear factor I/B [Source:HGNC Symbol;Acc:HGNC:7785] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0042995|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0042127|GO:0006935|GO:0035239|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:1901360|GO:0007275|GO:0030324|GO:0003676|GO:0048513|GO:0048857|GO:0034641|GO:0030902|GO:0030900|GO:2000795|GO:0031325|GO:0046483|GO:0007420|GO:0051098|GO:0043231|GO:0000981|GO:0060322|GO:0001076|GO:0006928|GO:0009887|GO:0043005|GO:0050673|GO:0009890|GO:0030323|GO:0006139|GO:0044092|GO:0035148|GO:0008285|GO:2000791|GO:0030030|GO:0048869|GO:0021537|GO:0044249|GO:0031324|GO:0031323|GO:0048732|GO:0072089|GO:0060425|GO:0000982|GO:0005730|GO:0000902|GO:0031175|GO:0060479|GO:0003677|GO:0010468|GO:0034645|GO:0051216|GO:0003714|GO:0051101|GO:0051100|GO:0030424|GO:0001104|GO:0007417|GO:0010629|GO:0051252|GO:0060541|GO:0010463|GO:0022612|GO:0000904|GO:0010628|GO:0060502|GO:2000647|GO:2000027|GO:0060916|GO:0007431|GO:0031981|GO:0006259|GO:0050678|GO:0021960|GO:0035272|GO:0050680|GO:0060429|GO:0010467|GO:0032990|GO:0007399|GO:0097485|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0001228|GO:0001191|GO:0016070|GO:0060428|GO:0010557|GO:0005634|GO:0072091|GO:0048666|GO:0030182|GO:0007411|GO:0021953|GO:0000975|GO:0045893|GO:0006260|GO:0010001|GO:0021740|GO:0030855|GO:0045892|GO:2000794|GO:0060487|GO:0002062|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:1902679|GO:0003690|GO:0061564|GO:0072201|GO:0021954|GO:0060689|GO:0007435|GO:0060662|GO:0022008|GO:0048667|GO:0001106|GO:0048812|GO:0044300|GO:0006351|GO:0006355|GO:0010464|GO:0043392|GO:0045944|GO:0006366|GO:1903507|GO:0021955|GO:0060486|GO:0006357|GO:0007409|GO:0048699|GO:0060509|GO:1903506|GO:0044212|GO:0061140|GO:0061141|GO:0042063|GO:0071679|GO:0000122|GO:0021952|GO:0060510|GO:0000976|GO:0001012|GO:0001159|GO:1902894|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cell projection|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cell proliferation|chemotaxis|tube morphogenesis|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|tube development|organic cyclic compound metabolic process|multicellular organism development|lung development|nucleic acid binding|animal organ development|neural nucleus development|cellular nitrogen compound metabolic process|hindbrain development|forebrain development|negative regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|regulation of binding|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|transcription factor activity, RNA polymerase II transcription factor binding|movement of cell or subcellular component|organ morphogenesis|neuron projection|epithelial cell proliferation|negative regulation of biosynthetic process|respiratory tube development|nucleobase-containing compound metabolic process|negative regulation of molecular function|tube formation|negative regulation of cell proliferation|negative regulation of mesenchymal cell proliferation involved in lung development|cell projection organization|cellular developmental process|telencephalon development|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|stem cell proliferation|lung morphogenesis|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nucleolus|cell morphogenesis|neuron projection development|lung cell differentiation|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|transcription corepressor activity|regulation of DNA binding|negative regulation of binding|axon|RNA polymerase II transcription cofactor activity|central nervous system development|negative regulation of gene expression|regulation of RNA metabolic process|respiratory system development|mesenchymal cell proliferation|gland morphogenesis|cell morphogenesis involved in differentiation|positive regulation of gene expression|epithelial cell proliferation involved in lung morphogenesis|negative regulation of stem cell proliferation|regulation of organ morphogenesis|mesenchymal cell proliferation involved in lung development|salivary gland development|nuclear lumen|DNA metabolic process|regulation of epithelial cell proliferation|anterior commissure morphogenesis|exocrine system development|negative regulation of epithelial cell proliferation|epithelium development|gene expression|cell part morphogenesis|nervous system development|neuron projection guidance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|lung epithelium development|positive regulation of macromolecule biosynthetic process|nucleus|regulation of stem cell proliferation|neuron development|neuron differentiation|axon guidance|central nervous system neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|DNA replication|glial cell differentiation|principal sensory nucleus of trigeminal nerve development|epithelial cell differentiation|negative regulation of transcription, DNA-templated|regulation of epithelial cell proliferation involved in lung morphogenesis|lung epithelial cell differentiation|chondrocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of RNA biosynthetic process|double-stranded DNA binding|axon development|negative regulation of mesenchymal cell proliferation|central nervous system neuron development|cell differentiation involved in salivary gland development|salivary gland morphogenesis|salivary gland cavitation|neurogenesis|cell morphogenesis involved in neuron differentiation|RNA polymerase II transcription corepressor activity|neuron projection morphogenesis|cerebellar mossy fiber|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of mesenchymal cell proliferation|negative regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|central nervous system neuron axonogenesis|Clara cell differentiation|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|Type I pneumocyte differentiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|lung secretory cell differentiation|lung ciliated cell differentiation|gliogenesis|commissural neuron axon guidance|negative regulation of transcription from RNA polymerase II promoter|central nervous system projection neuron axonogenesis|Type II pneumocyte differentiation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|negative regulation of pri-miRNA transcription from RNA polymerase II promoter|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 9:14081843-14398983 15 11 52 108 109 123 0.0397674965217542 0.026505406376359 0.12429788821541 0.256544942419323 0.237103560709664 0.305618396338794 0.0635235970378411 0.266422299822594 -2.06835032969835 4.71785007669343e-06 5.13664099889152e-05 DOWN ENSG00000237870 AC073130.1 - - - - - - - 7:116275606-116286734 0 0 0 6 8 8 0 0 0 0.113045515945603 0.138029564990493 0.157656504093979 0 0.136243861676692 -Inf 4.74733250938859e-06 5.16309161148587e-05 DOWN ENSG00000196517 SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 [Source:HGNC Symbol;Acc:HGNC:11056] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0022857|GO:0005326|GO:0051641|GO:0071944|GO:0031224|GO:0007269|GO:0005515|GO:0005886|GO:0061537|GO:0006810|GO:0032940|GO:0005887|GO:0007267|GO:0022891|GO:0005328|GO:0031226|GO:0007154|GO:0055085|GO:0051649|GO:0001505|GO:0016021|GO:0006836|GO:1903825|GO:0006811|GO:0015075|GO:0046903|GO:0034220|GO:0006820|GO:0015711|GO:0098656|GO:0015293|GO:0008509|GO:0006812|GO:0046942|GO:0046943|GO:0006865|GO:0005343|GO:0046717|GO:0008324|GO:0015804|GO:0015375|GO:0015171|GO:0005283|GO:0003333|GO:0015807|GO:0015187|GO:0022890|GO:0008514|GO:0007268|GO:0015816|GO:0015175|GO:0007270|GO:0015179|GO:0036233|GO:0015077|GO:0046873|GO:0060012|GO:0015081 transporter activity|signaling|cell|membrane|cellular process|binding|transmembrane transporter activity|neurotransmitter transporter activity|cellular localization|cell periphery|intrinsic component of membrane|neurotransmitter secretion|protein binding|plasma membrane|glycine secretion, neurotransmission|transport|secretion by cell|integral component of plasma membrane|cell-cell signaling|substrate-specific transmembrane transporter activity|neurotransmitter:sodium symporter activity|intrinsic component of plasma membrane|cell communication|transmembrane transport|establishment of localization in cell|regulation of neurotransmitter levels|integral component of membrane|neurotransmitter transport|organic acid transmembrane transport|ion transport|ion transmembrane transporter activity|secretion|ion transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|symporter activity|anion transmembrane transporter activity|cation transport|carboxylic acid transport|carboxylic acid transmembrane transporter activity|amino acid transport|organic acid:sodium symporter activity|acid secretion|cation transmembrane transporter activity|neutral amino acid transport|glycine:sodium symporter activity|amino acid transmembrane transporter activity|sodium:amino acid symporter activity|amino acid transmembrane transport|L-amino acid transport|glycine transmembrane transporter activity|inorganic cation transmembrane transporter activity|organic anion transmembrane transporter activity|synaptic transmission|glycine transport|neutral amino acid transmembrane transporter activity|neuron-neuron synaptic transmission|L-amino acid transmembrane transporter activity|glycine import|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|synaptic transmission, glycinergic|sodium ion transmembrane transporter activity - - - - 1:43991500-44031467 222 251 332 606 600 550 2.15058611954677 2.20982515016493 2.89972326432196 5.25986227273362 4.76895139978605 4.99339133751316 2.42004484467789 5.00740167001094 -1.04902840458661 4.75314169819299e-06 5.1656564703456e-05 DOWN ENSG00000237356 AL163953.3 - - - - - - - 14:53169054-53687258 0 0 3 11 10 21 0 0 0.0793449945305979 0.289156913964811 0.240729900641971 0.577412561772245 0.0264483315101993 0.369099792126342 -3.80276230699092 4.75315144504568e-06 5.1656564703456e-05 DOWN ENSG00000105723 GSK3A glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:HGNC:4616] GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0051051|GO:0044237|GO:0051641|GO:0006914|GO:0023051|GO:0045926|GO:0009653|GO:0016043|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0007507|GO:0060341|GO:0044262|GO:0010506|GO:0045087|GO:0045595|GO:0006725|GO:0009888|GO:0014741|GO:0048468|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0045596|GO:0048513|GO:0034641|GO:0043168|GO:0015980|GO:0046620|GO:0044281|GO:0006952|GO:0001882|GO:0016772|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0046621|GO:0010942|GO:1900076|GO:0035265|GO:2000077|GO:0061061|GO:0055017|GO:0048635|GO:0019899|GO:0010243|GO:0030308|GO:0005737|GO:0003012|GO:0051018|GO:0032880|GO:0005975|GO:0051222|GO:0009887|GO:0030877|GO:0031018|GO:0009966|GO:1903524|GO:0045184|GO:0009890|GO:1901862|GO:0032388|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0055086|GO:0008104|GO:0007154|GO:0044092|GO:0061024|GO:0007165|GO:0048588|GO:0000422|GO:0009968|GO:0048638|GO:0090559|GO:0051649|GO:0009725|GO:0008219|GO:0090316|GO:0016236|GO:0031016|GO:0048640|GO:0008217|GO:0050790|GO:0010829|GO:0000166|GO:0006091|GO:0043086|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0003013|GO:0006996|GO:0055114|GO:0003205|GO:0071774|GO:2001235|GO:0030111|GO:0006109|GO:0005829|GO:0045732|GO:0005976|GO:0007186|GO:0034645|GO:0030178|GO:1903008|GO:0007166|GO:0030968|GO:0009225|GO:0035639|GO:0003208|GO:0043412|GO:0072594|GO:0072358|GO:0034097|GO:0030163|GO:0034236|GO:0019693|GO:0008277|GO:0061052|GO:0007005|GO:0042692|GO:0002064|GO:0035051|GO:0032386|GO:0048738|GO:0001883|GO:0003007|GO:0061049|GO:0010721|GO:0051223|GO:0045823|GO:1903955|GO:0060420|GO:0015031|GO:1903146|GO:0044265|GO:1901652|GO:0055006|GO:0090257|GO:0071417|GO:0044275|GO:0051147|GO:0051347|GO:0036211|GO:0046902|GO:0030856|GO:0070201|GO:0060537|GO:0046907|GO:0032549|GO:0016241|GO:0045843|GO:0003309|GO:0006986|GO:0033692|GO:0035270|GO:0003231|GO:0043434|GO:0044344|GO:0005977|GO:0005996|GO:0051247|GO:0070848|GO:0006508|GO:0016052|GO:0002764|GO:0016301|GO:0055001|GO:0034613|GO:0019900|GO:0006112|GO:0012501|GO:0060429|GO:0043467|GO:0006796|GO:1901030|GO:0035556|GO:1901137|GO:0033043|GO:0044267|GO:0051174|GO:0010611|GO:0042176|GO:0014896|GO:0007399|GO:0071310|GO:1902532|GO:0017076|GO:0031328|GO:0046627|GO:0006626|GO:0019439|GO:0051246|GO:0009059|GO:0030154|GO:0045745|GO:0046626|GO:0043068|GO:0007517|GO:0035967|GO:1903827|GO:1902531|GO:0008643|GO:0072359|GO:0031667|GO:0016773|GO:0008015|GO:0034976|GO:0046325|GO:0046434|GO:0032870|GO:0010614|GO:0030857|GO:0016051|GO:0051148|GO:0043067|GO:0003073|GO:0097190|GO:0007006|GO:0010827|GO:0016202|GO:0010638|GO:0005978|GO:0003323|GO:0008016|GO:0034620|GO:0055002|GO:0016055|GO:0019318|GO:0044257|GO:0032006|GO:2000467|GO:1901028|GO:0055024|GO:0051153|GO:0033365|GO:0033157|GO:0008543|GO:0090090|GO:0051154|GO:0043065|GO:0010498|GO:2000466|GO:0031929|GO:0030855|GO:0071879|GO:0009259|GO:0036498|GO:1901653|GO:0060828|GO:0000271|GO:0009117|GO:2000465|GO:0055013|GO:0002066|GO:0005524|GO:0046390|GO:0006839|GO:0060047|GO:0045980|GO:0097192|GO:0008637|GO:0071363|GO:0030554|GO:0046324|GO:0016310|GO:0006605|GO:0072655|GO:0002768|GO:1904227|GO:0038179|GO:0010822|GO:0071877|GO:0003214|GO:0016482|GO:0006886|GO:0048017|GO:0010906|GO:0097345|GO:0051603|GO:0007167|GO:1902108|GO:0010905|GO:0035794|GO:0010821|GO:0006011|GO:0071375|GO:0071875|GO:0006163|GO:0051146|GO:0042981|GO:0071345|GO:0004672|GO:0045719|GO:2000074|GO:0032868|GO:0009166|GO:0019901|GO:0014706|GO:0055007|GO:0006464|GO:1903214|GO:0009165|GO:0097191|GO:0070873|GO:0006915|GO:0032007|GO:0055026|GO:0005979|GO:0048011|GO:0003300|GO:1903533|GO:0006164|GO:0030801|GO:0048015|GO:0008645|GO:0036016|GO:0019941|GO:0006468|GO:0006006|GO:0060070|GO:0002068|GO:0032869|GO:0038093|GO:0004674|GO:1902110|GO:0009187|GO:2000726|GO:0050321|GO:0030802|GO:0043161|GO:0070585|GO:0006258|GO:0007169|GO:0009190|GO:0006511|GO:0002067|GO:0046058|GO:0015758|GO:0030819|GO:0038095|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030816|GO:0008286|GO:0038127|GO:0046323|GO:0035883|GO:0006171|GO:0007173 developmental process|growth|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|organic substance metabolic process|catabolic process|ion binding|immune response|negative regulation of transport|cellular metabolic process|cellular localization|autophagy|regulation of signaling|negative regulation of growth|anatomical structure morphogenesis|cellular component organization|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|heart development|regulation of cellular localization|cellular carbohydrate metabolic process|regulation of autophagy|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|negative regulation of muscle hypertrophy|cell development|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|regulation of organ growth|small molecule metabolic process|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|negative regulation of organ growth|positive regulation of cell death|regulation of cellular response to insulin stimulus|organ growth|negative regulation of type B pancreatic cell development|muscle structure development|cardiac muscle tissue growth|negative regulation of muscle organ development|enzyme binding|response to organonitrogen compound|negative regulation of cell growth|cytoplasm|muscle system process|protein kinase A binding|regulation of protein localization|carbohydrate metabolic process|positive regulation of protein transport|organ morphogenesis|beta-catenin destruction complex|endocrine pancreas development|regulation of signal transduction|positive regulation of blood circulation|establishment of protein localization|negative regulation of biosynthetic process|negative regulation of muscle tissue development|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|nucleobase-containing small molecule metabolic process|protein localization|cell communication|negative regulation of molecular function|membrane organization|signal transduction|developmental cell growth|mitophagy|negative regulation of signal transduction|regulation of developmental growth|regulation of membrane permeability|establishment of localization in cell|response to hormone|cell death|positive regulation of intracellular protein transport|macroautophagy|pancreas development|negative regulation of developmental growth|regulation of blood pressure|regulation of catalytic activity|negative regulation of glucose transport|nucleotide binding|generation of precursor metabolites and energy|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|organelle organization|oxidation-reduction process|cardiac chamber development|response to fibroblast growth factor|positive regulation of apoptotic signaling pathway|regulation of Wnt signaling pathway|regulation of carbohydrate metabolic process|cytosol|positive regulation of protein catabolic process|polysaccharide metabolic process|G-protein coupled receptor signaling pathway|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|organelle disassembly|cell surface receptor signaling pathway|endoplasmic reticulum unfolded protein response|nucleotide-sugar metabolic process|purine ribonucleoside triphosphate binding|cardiac ventricle morphogenesis|macromolecule modification|establishment of protein localization to organelle|cardiovascular system development|response to cytokine|protein catabolic process|protein kinase A catalytic subunit binding|ribose phosphate metabolic process|regulation of G-protein coupled receptor protein signaling pathway|negative regulation of cell growth involved in cardiac muscle cell development|mitochondrion organization|muscle cell differentiation|epithelial cell development|cardiocyte differentiation|regulation of intracellular transport|cardiac muscle tissue development|purine nucleoside binding|heart morphogenesis|cell growth involved in cardiac muscle cell development|negative regulation of cell development|regulation of protein transport|positive regulation of heart contraction|positive regulation of protein targeting to mitochondrion|regulation of heart growth|protein transport|regulation of mitophagy|cellular macromolecule catabolic process|response to peptide|cardiac cell development|regulation of muscle system process|cellular response to organonitrogen compound|cellular carbohydrate catabolic process|regulation of muscle cell differentiation|positive regulation of transferase activity|protein modification process|regulation of mitochondrial membrane permeability|regulation of epithelial cell differentiation|regulation of establishment of protein localization|muscle tissue development|intracellular transport|ribonucleoside binding|regulation of macroautophagy|negative regulation of striated muscle tissue development|type B pancreatic cell differentiation|response to unfolded protein|cellular polysaccharide biosynthetic process|endocrine system development|cardiac ventricle development|response to peptide hormone|cellular response to fibroblast growth factor stimulus|glycogen metabolic process|monosaccharide metabolic process|positive regulation of protein metabolic process|response to growth factor|proteolysis|carbohydrate catabolic process|immune response-regulating signaling pathway|kinase activity|muscle cell development|cellular protein localization|kinase binding|energy reserve metabolic process|programmed cell death|epithelium development|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|intracellular signal transduction|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of cardiac muscle hypertrophy|regulation of protein catabolic process|muscle hypertrophy|nervous system development|cellular response to organic substance|negative regulation of intracellular signal transduction|purine nucleotide binding|positive regulation of cellular biosynthetic process|negative regulation of insulin receptor signaling pathway|protein targeting to mitochondrion|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|positive regulation of G-protein coupled receptor protein signaling pathway|regulation of insulin receptor signaling pathway|positive regulation of programmed cell death|muscle organ development|cellular response to topologically incorrect protein|regulation of cellular protein localization|regulation of intracellular signal transduction|carbohydrate transport|circulatory system development|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|blood circulation|response to endoplasmic reticulum stress|negative regulation of glucose import|organophosphate catabolic process|cellular response to hormone stimulus|negative regulation of cardiac muscle hypertrophy|negative regulation of epithelial cell differentiation|carbohydrate biosynthetic process|negative regulation of muscle cell differentiation|regulation of programmed cell death|regulation of systemic arterial blood pressure|apoptotic signaling pathway|mitochondrial membrane organization|regulation of glucose transport|regulation of striated muscle tissue development|positive regulation of organelle organization|glycogen biosynthetic process|type B pancreatic cell development|regulation of heart contraction|cellular response to unfolded protein|striated muscle cell development|Wnt signaling pathway|hexose metabolic process|cellular protein catabolic process|regulation of TOR signaling|positive regulation of glycogen (starch) synthase activity|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|regulation of cardiac muscle tissue development|regulation of striated muscle cell differentiation|protein localization to organelle|regulation of intracellular protein transport|fibroblast growth factor receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|negative regulation of striated muscle cell differentiation|positive regulation of apoptotic process|proteasomal protein catabolic process|negative regulation of glycogen (starch) synthase activity|TOR signaling|epithelial cell differentiation|positive regulation of adrenergic receptor signaling pathway|ribonucleotide metabolic process|IRE1-mediated unfolded protein response|cellular response to peptide|regulation of canonical Wnt signaling pathway|polysaccharide biosynthetic process|nucleotide metabolic process|regulation of glycogen (starch) synthase activity|cardiac muscle cell development|columnar/cuboidal epithelial cell development|ATP binding|ribose phosphate biosynthetic process|mitochondrial transport|heart contraction|negative regulation of nucleotide metabolic process|extrinsic apoptotic signaling pathway in absence of ligand|apoptotic mitochondrial changes|cellular response to growth factor stimulus|adenyl nucleotide binding|regulation of glucose import|phosphorylation|protein targeting|establishment of protein localization to mitochondrion|immune response-regulating cell surface receptor signaling pathway|negative regulation of glycogen synthase activity, transferring glucose-1-phosphate|neurotrophin signaling pathway|positive regulation of mitochondrion organization|regulation of adrenergic receptor signaling pathway|cardiac left ventricle morphogenesis|cytosolic transport|intracellular protein transport|inositol lipid-mediated signaling|regulation of glucose metabolic process|mitochondrial outer membrane permeabilization|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|regulation of mitochondrial membrane permeability involved in apoptotic process|negative regulation of UDP-glucose catabolic process|positive regulation of mitochondrial membrane permeability|regulation of mitochondrion organization|UDP-glucose metabolic process|cellular response to peptide hormone stimulus|adrenergic receptor signaling pathway|purine nucleotide metabolic process|striated muscle cell differentiation|regulation of apoptotic process|cellular response to cytokine stimulus|protein kinase activity|negative regulation of glycogen biosynthetic process|regulation of type B pancreatic cell development|response to insulin|nucleotide catabolic process|protein kinase binding|striated muscle tissue development|cardiac muscle cell differentiation|cellular protein modification process|regulation of protein targeting to mitochondrion|nucleotide biosynthetic process|extrinsic apoptotic signaling pathway|regulation of glycogen metabolic process|apoptotic process|negative regulation of TOR signaling|negative regulation of cardiac muscle tissue development|regulation of glycogen biosynthetic process|neurotrophin TRK receptor signaling pathway|cardiac muscle hypertrophy|regulation of protein targeting|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|phosphatidylinositol-mediated signaling|hexose transport|cellular response to interleukin-3|modification-dependent protein catabolic process|protein phosphorylation|glucose metabolic process|canonical Wnt signaling pathway|glandular epithelial cell development|cellular response to insulin stimulus|Fc receptor signaling pathway|protein serine/threonine kinase activity|positive regulation of mitochondrial membrane permeability involved in apoptotic process|cyclic nucleotide metabolic process|negative regulation of cardiac muscle cell differentiation|tau-protein kinase activity|regulation of cyclic nucleotide biosynthetic process|proteasome-mediated ubiquitin-dependent protein catabolic process|protein localization to mitochondrion|UDP-glucose catabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|cyclic nucleotide biosynthetic process|ubiquitin-dependent protein catabolic process|glandular epithelial cell differentiation|cAMP metabolic process|glucose transport|positive regulation of cAMP biosynthetic process|Fc-epsilon receptor signaling pathway|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|positive regulation of cAMP metabolic process|insulin receptor signaling pathway|ERBB signaling pathway|glucose import|enteroendocrine cell differentiation|cAMP biosynthetic process|epidermal growth factor receptor signaling pathway K08822 glycogen synthase kinase 3 alpha[2.7.11.26] hsa04062|hsa04932|hsa04728 Chemokine signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human) 19:42230186-42242625 2273 2325 1613 1112 1264 944 25.6230825399092 23.8196319213453 16.3938318027685 11.2314160517856 11.6908754631797 9.97315872443992 21.945515421341 10.9651500798017 1.00100059603423 4.78074359378516e-06 5.19375251997315e-05 UP ENSG00000155269 GPR78 G protein-coupled receptor 78 [Source:HGNC Symbol;Acc:HGNC:4528] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0004930|GO:0007187|GO:0007188|GO:0007189 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor activity|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|adenylate cyclase-activating G-protein coupled receptor signaling pathway - - - - 4:8558725-8619761 179 163 286 477 457 656 1.03998940335008 0.860686707478127 1.49815652013009 2.48309428017852 2.1785170513601 3.57198182813667 1.13294421031943 2.7445310532251 -1.27648284276088 4.8167836157181e-06 5.22910029322356e-05 DOWN ENSG00000171425 ZNF581 zinc finger protein 581 [Source:HGNC Symbol;Acc:HGNC:25017] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:55635459-55645622 2170 2149 3708 1098 1126 1734 47.3324044958369 42.6005440305919 72.9210224962287 21.4584655530246 20.1514046887907 35.4467895216761 54.2846570075525 25.6855532544971 1.07958734395012 4.81587793847768e-06 5.22910029322356e-05 UP ENSG00000161526 SAP30BP SAP30 binding protein [Source:HGNC Symbol;Acc:HGNC:30785] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0010941|GO:0034641|GO:0046483|GO:0010942|GO:0043231|GO:0006139|GO:0008219|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0031981|GO:0005654|GO:0012501|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0045814|GO:0032774|GO:2001141|GO:0040029|GO:0045111|GO:0006351|GO:0006915|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell death|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cell death|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|programmed cell death|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|negative regulation of gene expression, epigenetic|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|intermediate filament cytoskeleton|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 17:75667116-75708062 219 253 256 543 618 466 0.803284730392096 0.843386976959422 0.84660517609729 1.7845277043603 1.85987111062036 1.60192044424624 0.831092294482936 1.74877308640897 -1.07326249802682 4.87188436602825e-06 5.28699512407879e-05 DOWN ENSG00000136783 NIPSNAP3A nipsnap homolog 3A (C. elegans) [Source:HGNC Symbol;Acc:HGNC:23619] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005829|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|cytosol|nucleus - - - - 9:104747688-104760122 94 106 114 266 279 221 2.39096951523625 2.45036102854418 2.61434652375553 6.06211065426452 5.82260551390232 5.26824277741321 2.48522568917865 5.71765298186002 -1.20204618972683 4.89091592943354e-06 5.30571962780919e-05 DOWN ENSG00000130413 STK33 serine/threonine kinase 33 [Source:HGNC Symbol;Acc:HGNC:14568] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0043167|GO:0044237|GO:0005622|GO:0005515|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0005737|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0048471|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674|GO:0046777 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|ion binding|cellular metabolic process|intracellular|protein binding|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cytoplasm|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|perinuclear region of cytoplasm|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity|protein autophosphorylation - - - - 11:8391868-8594289 3 7 6 31 52 17 0.0160600695663219 0.0340553567318469 0.0289571178191662 0.148672739575771 0.228377538003011 0.0852817786547114 0.0263575147057783 0.154110685411164 -2.54768064821645 4.93262444338876e-06 5.34902179923458e-05 DOWN ENSG00000205420 KRT6A keratin 6A, type II [Source:HGNC Symbol;Acc:HGNC:6443] GO:0032502|GO:0002376|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0005200|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0009056|GO:0006914|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0002682|GO:0005515|GO:0048856|GO:0008284|GO:0042127|GO:0009888|GO:0050688|GO:0006952|GO:0031982|GO:0033554|GO:0005882|GO:0098542|GO:0043231|GO:0009611|GO:0009615|GO:0048729|GO:0000422|GO:0070062|GO:0016236|GO:0051607|GO:0048869|GO:0006996|GO:1903008|GO:0098792|GO:0002009|GO:0000423|GO:0007005|GO:0042060|GO:0045095|GO:0060429|GO:0030154|GO:0005856|GO:0005634|GO:0050691|GO:0002230|GO:0045111|GO:0098779 developmental process|immune system process|structural molecule activity|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|structural constituent of cytoskeleton|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|catabolic process|autophagy|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|regulation of immune system process|protein binding|anatomical structure development|positive regulation of cell proliferation|regulation of cell proliferation|tissue development|regulation of defense response to virus|defense response|vesicle|cellular response to stress|intermediate filament|defense response to other organism|intracellular membrane-bounded organelle|response to wounding|response to virus|tissue morphogenesis|mitophagy|extracellular exosome|macroautophagy|defense response to virus|cellular developmental process|organelle organization|organelle disassembly|xenophagy|morphogenesis of an epithelium|macromitophagy|mitochondrion organization|wound healing|keratin filament|epithelium development|cell differentiation|cytoskeleton|nucleus|regulation of defense response to virus by host|positive regulation of defense response to virus by host|intermediate filament cytoskeleton|mitophagy in response to mitochondrial depolarization - - - - 12:52487174-52493257 124 137 131 54 73 32 2.21108126323818 2.22016405583322 2.10604769153804 0.862726948410634 1.0680145832722 0.534768318398938 2.17909767020315 0.821836616693924 1.40680734559857 4.959325427155e-06 5.37212268876217e-05 UP ENSG00000173137 ADCK5 aarF domain containing kinase 5 [Source:HGNC Symbol;Acc:HGNC:21738] GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0044237|GO:0031224|GO:0005515|GO:0016740|GO:0016772|GO:0016021|GO:0019538|GO:0043412|GO:0036211|GO:0016301|GO:0006796|GO:0044267|GO:0016773|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 membrane|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|cellular metabolic process|intrinsic component of membrane|protein binding|transferase activity|transferase activity, transferring phosphorus-containing groups|integral component of membrane|protein metabolic process|macromolecule modification|protein modification process|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|phosphotransferase activity, alcohol group as acceptor|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 8:144373101-144393242 90 116 148 293 287 274 1.40350214046086 1.64403153464993 2.08088287083303 4.09391108703442 3.67216474194035 4.00453059292496 1.70947218198127 3.92353547396658 -1.19860329796395 4.97092541969702e-06 5.38078344741243e-05 DOWN ENSG00000110693 SOX6 SRY-box 6 [Source:HGNC Symbol;Acc:HGNC:16421] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0002262|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0007507|GO:0009791|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034101|GO:0034641|GO:0061036|GO:0031325|GO:0046483|GO:0061061|GO:0045597|GO:0043231|GO:0071559|GO:0042592|GO:0046983|GO:0009890|GO:0016458|GO:0006139|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0000902|GO:0003677|GO:0010468|GO:0034645|GO:0030218|GO:0051216|GO:2000736|GO:0030097|GO:0072358|GO:0007417|GO:0010629|GO:0042692|GO:0046982|GO:0051252|GO:0035051|GO:0048738|GO:0009790|GO:0010628|GO:0071560|GO:0060537|GO:0048872|GO:0032330|GO:0031981|GO:0001708|GO:0070848|GO:0005654|GO:0010467|GO:0007399|GO:0071310|GO:0031328|GO:0032332|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0061035|GO:0007517|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0045165|GO:2000738|GO:2000741|GO:0000975|GO:0045893|GO:0048863|GO:0009792|GO:0010001|GO:0045892|GO:0002062|GO:0032774|GO:0043565|GO:2001141|GO:0071363|GO:1902679|GO:2000739|GO:0021781|GO:0051146|GO:0048709|GO:0048821|GO:0030099|GO:0014706|GO:0022008|GO:0055007|GO:0048708|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0021778|GO:0042063|GO:0043009|GO:0000122|GO:0021779|GO:0001701 developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|myeloid cell homeostasis|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|anatomical structure development|regulation of metabolic process|heart development|post-embryonic development|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|erythrocyte homeostasis|cellular nitrogen compound metabolic process|positive regulation of cartilage development|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|response to transforming growth factor beta|homeostatic process|protein dimerization activity|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cell morphogenesis|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|erythrocyte differentiation|cartilage development|regulation of stem cell differentiation|hemopoiesis|cardiovascular system development|central nervous system development|negative regulation of gene expression|muscle cell differentiation|protein heterodimerization activity|regulation of RNA metabolic process|cardiocyte differentiation|cardiac muscle tissue development|embryo development|positive regulation of gene expression|cellular response to transforming growth factor beta stimulus|muscle tissue development|homeostasis of number of cells|regulation of chondrocyte differentiation|nuclear lumen|cell fate specification|response to growth factor|nucleoplasm|gene expression|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|positive regulation of chondrocyte differentiation|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|regulation of cartilage development|muscle organ development|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|cell fate commitment|positive regulation of stem cell differentiation|positive regulation of mesenchymal stem cell differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|stem cell differentiation|embryo development ending in birth or egg hatching|glial cell differentiation|negative regulation of transcription, DNA-templated|chondrocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|negative regulation of RNA biosynthetic process|regulation of mesenchymal stem cell differentiation|glial cell fate commitment|striated muscle cell differentiation|oligodendrocyte differentiation|erythrocyte development|myeloid cell differentiation|striated muscle tissue development|neurogenesis|cardiac muscle cell differentiation|astrocyte differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|oligodendrocyte cell fate specification|gliogenesis|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|oligodendrocyte cell fate commitment|in utero embryonic development - - - - 11:15966449-16739591 3 2 8 20 23 51 0.00946205168608756 0.00573226055096473 0.0227474104312844 0.056511499506226 0.0595128408805517 0.150735448718949 0.0126472408894456 0.0889199297019089 -2.81368412559346 5.00639241317467e-06 5.41047218442307e-05 DOWN ENSG00000273604 C17orf96 chromosome 17 open reading frame 96 [Source:HGNC Symbol;Acc:HGNC:34493] GO:0032502|GO:0009987|GO:0005488|GO:0005515|GO:0048856|GO:0007275|GO:0048869|GO:0007399|GO:0030154|GO:0045165|GO:0030182|GO:0048663|GO:0022008|GO:0048699 developmental process|cellular process|binding|protein binding|anatomical structure development|multicellular organism development|cellular developmental process|nervous system development|cell differentiation|cell fate commitment|neuron differentiation|neuron fate commitment|neurogenesis|generation of neurons - - - - 17:38671703-38675421 325 392 344 154 229 161 6.18163518790278 6.77619878040091 5.89917965896365 2.62445031201729 3.57373624718266 2.86995020813935 6.28567120908911 3.02271225577977 1.05622316009442 5.01225864517737e-06 5.41374709092349e-05 UP ENSG00000196338 NLGN3 neuroligin 3 [Source:HGNC Symbol;Acc:HGNC:14289] GO:0032502|GO:0040007|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:1902474|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0051050|GO:0016049|GO:0044089|GO:0009628|GO:0009986|GO:0051641|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0060077|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0023057|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0043576|GO:0060341|GO:0071625|GO:0007585|GO:0016337|GO:0050804|GO:2000809|GO:0042391|GO:0045595|GO:0051640|GO:0048468|GO:0043025|GO:0030534|GO:0009314|GO:0006810|GO:0051130|GO:2000807|GO:0007275|GO:0045596|GO:0050877|GO:0005102|GO:0016358|GO:0043270|GO:0031982|GO:0051128|GO:0007632|GO:0050806|GO:0022607|GO:0098609|GO:0050803|GO:0005887|GO:0045597|GO:0043231|GO:0005737|GO:0007267|GO:0032880|GO:0051963|GO:0051656|GO:0097110|GO:0043005|GO:0009966|GO:0050839|GO:0036477|GO:0010646|GO:0031226|GO:0008104|GO:0007154|GO:0035176|GO:0055085|GO:0060996|GO:0061024|GO:0007165|GO:0048588|GO:0051965|GO:0009968|GO:0003016|GO:0050808|GO:0051649|GO:0044091|GO:0007611|GO:0030030|GO:0050805|GO:0048869|GO:0016021|GO:0009967|GO:0010469|GO:0032411|GO:0072553|GO:0060560|GO:0050768|GO:0016192|GO:0051650|GO:0000902|GO:0060998|GO:0071709|GO:0031175|GO:2000171|GO:0031344|GO:2000463|GO:0048167|GO:0007416|GO:0007166|GO:0060997|GO:0050807|GO:0050773|GO:0007417|GO:0031410|GO:0007612|GO:1901631|GO:0010720|GO:0097061|GO:0048813|GO:0002087|GO:0060078|GO:0010721|GO:0048489|GO:0031346|GO:0000904|GO:0097090|GO:0034767|GO:0016023|GO:0051968|GO:2000969|GO:0046907|GO:0006811|GO:2000331|GO:0031345|GO:0060999|GO:0042043|GO:0060024|GO:0097091|GO:0050769|GO:0051966|GO:0097151|GO:0030425|GO:0031988|GO:0034765|GO:0022604|GO:0035418|GO:0043269|GO:0060291|GO:0044065|GO:0007158|GO:0001941|GO:0032990|GO:0007399|GO:0061000|GO:1900451|GO:0050890|GO:0032414|GO:0098815|GO:0051648|GO:0030154|GO:0048858|GO:0090394|GO:1900006|GO:0009416|GO:1990138|GO:0022898|GO:0051960|GO:0008542|GO:2000273|GO:0034220|GO:0048666|GO:0030182|GO:0010975|GO:2000310|GO:0007215|GO:0010001|GO:0030139|GO:0010769|GO:0008306|GO:0097104|GO:0061564|GO:0016482|GO:0032412|GO:2000311|GO:0048814|GO:0036465|GO:0060080|GO:0048709|GO:1900271|GO:0060079|GO:0050774|GO:0045665|GO:0006897|GO:0022008|GO:0061002|GO:0048667|GO:0050767|GO:0048812|GO:0097105|GO:0010976|GO:0010977|GO:0061001|GO:0048675|GO:0045666|GO:0007409|GO:0048488|GO:0048699|GO:0006898|GO:0042063|GO:0045664|GO:0007268|GO:0007270|GO:0072583|GO:0035249 developmental process|growth|synapse|behavior|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|positive regulation of protein localization to synapse|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|positive regulation of transport|cell growth|positive regulation of cellular component biogenesis|response to abiotic stimulus|cell surface|cellular localization|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|inhibitory synapse|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|negative regulation of signaling|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of respiratory gaseous exchange|regulation of cellular localization|vocalization behavior|respiratory gaseous exchange|single organismal cell-cell adhesion|modulation of synaptic transmission|positive regulation of synaptic vesicle clustering|regulation of membrane potential|regulation of cell differentiation|organelle localization|cell development|neuronal cell body|adult behavior|response to radiation|transport|positive regulation of cellular component organization|regulation of synaptic vesicle clustering|multicellular organism development|negative regulation of cell differentiation|neurological system process|receptor binding|dendrite development|positive regulation of ion transport|vesicle|regulation of cellular component organization|visual behavior|positive regulation of synaptic transmission|cellular component assembly|cell-cell adhesion|regulation of synapse structure or activity|integral component of plasma membrane|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|regulation of protein localization|regulation of synapse assembly|establishment of organelle localization|scaffold protein binding|neuron projection|regulation of signal transduction|cell adhesion molecule binding|somatodendritic compartment|regulation of cell communication|intrinsic component of plasma membrane|protein localization|cell communication|social behavior|transmembrane transport|dendritic spine development|membrane organization|signal transduction|developmental cell growth|positive regulation of synapse assembly|negative regulation of signal transduction|respiratory system process|synapse organization|establishment of localization in cell|membrane biogenesis|learning or memory|cell projection organization|negative regulation of synaptic transmission|cellular developmental process|integral component of membrane|positive regulation of signal transduction|regulation of receptor activity|positive regulation of transporter activity|terminal button organization|developmental growth involved in morphogenesis|negative regulation of neurogenesis|vesicle-mediated transport|establishment of vesicle localization|cell morphogenesis|regulation of dendritic spine development|membrane assembly|neuron projection development|negative regulation of dendrite development|regulation of cell projection organization|positive regulation of excitatory postsynaptic potential|regulation of synaptic plasticity|synapse assembly|cell surface receptor signaling pathway|dendritic spine morphogenesis|regulation of synapse organization|regulation of dendrite development|central nervous system development|cytoplasmic vesicle|learning|positive regulation of presynaptic membrane organization|positive regulation of cell development|dendritic spine organization|dendrite morphogenesis|regulation of respiratory gaseous exchange by neurological system process|regulation of postsynaptic membrane potential|negative regulation of cell development|synaptic vesicle transport|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|presynaptic membrane organization|positive regulation of ion transmembrane transport|cytoplasmic, membrane-bounded vesicle|positive regulation of synaptic transmission, glutamatergic|positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|intracellular transport|ion transport|regulation of terminal button organization|negative regulation of cell projection organization|positive regulation of dendritic spine development|neurexin family protein binding|rhythmic synaptic transmission|synaptic vesicle clustering|positive regulation of neurogenesis|regulation of synaptic transmission, glutamatergic|positive regulation of inhibitory postsynaptic potential|dendrite|membrane-bounded vesicle|regulation of ion transmembrane transport|regulation of cell morphogenesis|protein localization to synapse|regulation of ion transport|long-term synaptic potentiation|regulation of respiratory system process|neuron cell-cell adhesion|postsynaptic membrane organization|cell part morphogenesis|nervous system development|negative regulation of dendritic spine development|positive regulation of glutamate receptor signaling pathway|cognition|positive regulation of ion transmembrane transporter activity|modulation of excitatory postsynaptic potential|vesicle localization|cell differentiation|cell projection morphogenesis|negative regulation of excitatory postsynaptic potential|positive regulation of dendrite development|response to light stimulus|neuron projection extension|regulation of transmembrane transporter activity|regulation of nervous system development|visual learning|positive regulation of receptor activity|ion transmembrane transport|neuron development|neuron differentiation|regulation of neuron projection development|regulation of N-methyl-D-aspartate selective glutamate receptor activity|glutamate receptor signaling pathway|glial cell differentiation|endocytic vesicle|regulation of cell morphogenesis involved in differentiation|associative learning|postsynaptic membrane assembly|axon development|cytosolic transport|regulation of ion transmembrane transporter activity|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of dendrite morphogenesis|synaptic vesicle recycling|inhibitory postsynaptic potential|oligodendrocyte differentiation|regulation of long-term synaptic potentiation|excitatory postsynaptic potential|negative regulation of dendrite morphogenesis|negative regulation of neuron differentiation|endocytosis|neurogenesis|negative regulation of dendritic spine morphogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|presynaptic membrane assembly|positive regulation of neuron projection development|negative regulation of neuron projection development|regulation of dendritic spine morphogenesis|axon extension|positive regulation of neuron differentiation|axonogenesis|synaptic vesicle endocytosis|generation of neurons|receptor-mediated endocytosis|gliogenesis|regulation of neuron differentiation|synaptic transmission|neuron-neuron synaptic transmission|clathrin-mediated endocytosis|synaptic transmission, glutamatergic K07378 neuroligin[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) X:71144831-71171201 91 84 122 18 13 49 0.588019768206181 0.493298015405302 0.710762957754438 0.104210398164883 0.0689205472278234 0.296741081941226 0.597360247121974 0.156624009111311 1.93129585067909 5.0162169309656e-06 5.41584654182414e-05 UP ENSG00000124762 CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) [Source:HGNC Symbol;Acc:HGNC:1784] GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0045926|GO:0016043|GO:0043227|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0048565|GO:0004857|GO:0045087|GO:0006725|GO:0070661|GO:0009888|GO:0048468|GO:0009314|GO:0050867|GO:0006810|GO:0022402|GO:0035295|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0048513|GO:0046685|GO:0034641|GO:0008047|GO:0006952|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0010942|GO:0045786|GO:0043231|GO:0043169|GO:0019899|GO:0010243|GO:0030308|GO:0048144|GO:0005737|GO:0030332|GO:0031668|GO:0032880|GO:0009408|GO:0032403|GO:0072593|GO:0002696|GO:0001775|GO:0045184|GO:0045787|GO:0060548|GO:0042493|GO:0006139|GO:0043085|GO:0000307|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0007165|GO:0070557|GO:0051649|GO:0009725|GO:0008219|GO:0008285|GO:0050790|GO:0019207|GO:0043086|GO:0048869|GO:0044249|GO:0009266|GO:0019538|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0042594|GO:0055093|GO:0007568|GO:0009636|GO:0071774|GO:0060575|GO:0051249|GO:0032268|GO:0005829|GO:0042113|GO:0019210|GO:0010468|GO:0000075|GO:0034645|GO:0032943|GO:0090068|GO:0055123|GO:0046872|GO:0007166|GO:0033993|GO:1903047|GO:0043412|GO:0072594|GO:0010629|GO:0019887|GO:0045736|GO:0043069|GO:0002064|GO:0031100|GO:0032386|GO:0044770|GO:0051223|GO:0015031|GO:0007050|GO:0051347|GO:0036211|GO:0032269|GO:2000377|GO:0000278|GO:0070201|GO:0046907|GO:0051251|GO:0048145|GO:0007569|GO:0031981|GO:0007346|GO:1990234|GO:0044344|GO:0010564|GO:0071478|GO:0034605|GO:0051247|GO:0045930|GO:0048146|GO:0048471|GO:0070848|GO:0005654|GO:0006259|GO:0002764|GO:0009267|GO:0016301|GO:0034613|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0010212|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0017038|GO:0019209|GO:0071310|GO:0051246|GO:0046651|GO:0009059|GO:0030154|GO:0043068|GO:0072395|GO:0031669|GO:0048469|GO:1903827|GO:0031667|GO:0016773|GO:0005634|GO:0009416|GO:0090398|GO:0043067|GO:0048545|GO:0097305|GO:0006974|GO:0006606|GO:0097190|GO:0010948|GO:0044389|GO:2000379|GO:0031625|GO:1904589|GO:0097193|GO:0033365|GO:1904031|GO:0033157|GO:0031401|GO:0008543|GO:0071156|GO:0009411|GO:0071850|GO:0051169|GO:0030855|GO:0051412|GO:0007093|GO:0072331|GO:0042770|GO:0000086|GO:0002066|GO:0044772|GO:0071363|GO:0016310|GO:0006605|GO:0002768|GO:0044774|GO:0038179|GO:0000077|GO:0050871|GO:1904030|GO:0016482|GO:1901990|GO:0006886|GO:0048017|GO:2000278|GO:0007167|GO:0008630|GO:0030295|GO:0050864|GO:0071482|GO:0004860|GO:0042981|GO:0090399|GO:0034198|GO:0043066|GO:0004672|GO:0016538|GO:0033673|GO:1901987|GO:0071479|GO:0042306|GO:0042100|GO:1900180|GO:0010165|GO:0002070|GO:0007264|GO:0006464|GO:0000060|GO:0060576|GO:0031960|GO:0050671|GO:0071897|GO:0000079|GO:0043549|GO:0006915|GO:0090400|GO:0044773|GO:1901991|GO:0071158|GO:0033674|GO:0032946|GO:0048011|GO:0019912|GO:0030291|GO:0051384|GO:1903533|GO:0010224|GO:2000045|GO:0030890|GO:0007265|GO:0006913|GO:0072332|GO:0045859|GO:0048015|GO:0045860|GO:0006469|GO:1902911|GO:0044819|GO:0006468|GO:0042771|GO:0044783|GO:0060574|GO:0033158|GO:0042325|GO:0001932|GO:1902806|GO:0051385|GO:0042326|GO:0038093|GO:2000134|GO:0000082|GO:0004861|GO:0030888|GO:0001934|GO:0001933|GO:0031571|GO:0034644|GO:0042327|GO:1902807|GO:0006977|GO:0030330|GO:0034504|GO:0046822|GO:0072422|GO:0007169|GO:0072431|GO:0051170|GO:1902554|GO:0038095|GO:0071901|GO:0071900|GO:0038127|GO:0071493|GO:0007173 developmental process|growth|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|negative regulation of growth|cellular component organization|membrane-bounded organelle|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|digestive tract development|enzyme inhibitor activity|innate immune response|cellular aromatic compound metabolic process|leukocyte proliferation|tissue development|cell development|response to radiation|positive regulation of cell activation|transport|cell cycle process|tube development|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|animal organ development|response to arsenic-containing substance|cellular nitrogen compound metabolic process|enzyme activator activity|defense response|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|enzyme binding|response to organonitrogen compound|negative regulation of cell growth|fibroblast proliferation|cytoplasm|cyclin binding|cellular response to extracellular stimulus|regulation of protein localization|response to heat|protein complex binding|reactive oxygen species metabolic process|positive regulation of leukocyte activation|cell activation|establishment of protein localization|positive regulation of cell cycle|negative regulation of cell death|response to drug|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cyclin-dependent protein kinase holoenzyme complex|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|signal transduction|PCNA-p21 complex|establishment of localization in cell|response to hormone|cell death|negative regulation of cell proliferation|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to starvation|response to hyperoxia|aging|response to toxic substance|response to fibroblast growth factor|intestinal epithelial cell differentiation|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cytosol|B cell activation|kinase inhibitor activity|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|mononuclear cell proliferation|positive regulation of cell cycle process|digestive system development|metal ion binding|cell surface receptor signaling pathway|response to lipid|mitotic cell cycle process|macromolecule modification|establishment of protein localization to organelle|negative regulation of gene expression|protein kinase regulator activity|negative regulation of cyclin-dependent protein serine/threonine kinase activity|negative regulation of programmed cell death|epithelial cell development|organ regeneration|regulation of intracellular transport|cell cycle phase transition|regulation of protein transport|protein transport|cell cycle arrest|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of reactive oxygen species metabolic process|mitotic cell cycle|regulation of establishment of protein localization|intracellular transport|positive regulation of lymphocyte activation|regulation of fibroblast proliferation|cell aging|nuclear lumen|regulation of mitotic cell cycle|transferase complex|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|cellular response to radiation|cellular response to heat|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|response to growth factor|nucleoplasm|DNA metabolic process|immune response-regulating signaling pathway|cellular response to starvation|kinase activity|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|response to ionizing radiation|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|protein import|kinase activator activity|cellular response to organic substance|regulation of protein metabolic process|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|signal transduction involved in cell cycle checkpoint|cellular response to nutrient levels|cell maturation|regulation of cellular protein localization|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|nucleus|response to light stimulus|cellular senescence|regulation of programmed cell death|response to steroid hormone|response to alcohol|cellular response to DNA damage stimulus|protein import into nucleus|apoptotic signaling pathway|negative regulation of cell cycle process|ubiquitin-like protein ligase binding|positive regulation of reactive oxygen species metabolic process|ubiquitin protein ligase binding|regulation of protein import|intrinsic apoptotic signaling pathway|protein localization to organelle|positive regulation of cyclin-dependent protein kinase activity|regulation of intracellular protein transport|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|regulation of cell cycle arrest|response to UV|mitotic cell cycle arrest|nuclear transport|epithelial cell differentiation|response to corticosterone|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|G2/M transition of mitotic cell cycle|columnar/cuboidal epithelial cell development|mitotic cell cycle phase transition|cellular response to growth factor stimulus|phosphorylation|protein targeting|immune response-regulating cell surface receptor signaling pathway|mitotic DNA integrity checkpoint|neurotrophin signaling pathway|DNA damage checkpoint|positive regulation of B cell activation|negative regulation of cyclin-dependent protein kinase activity|cytosolic transport|regulation of mitotic cell cycle phase transition|intracellular protein transport|inositol lipid-mediated signaling|regulation of DNA biosynthetic process|enzyme linked receptor protein signaling pathway|intrinsic apoptotic signaling pathway in response to DNA damage|protein kinase activator activity|regulation of B cell activation|cellular response to light stimulus|protein kinase inhibitor activity|regulation of apoptotic process|replicative senescence|cellular response to amino acid starvation|negative regulation of apoptotic process|protein kinase activity|cyclin-dependent protein serine/threonine kinase regulator activity|negative regulation of kinase activity|regulation of cell cycle phase transition|cellular response to ionizing radiation|regulation of protein import into nucleus|B cell proliferation|regulation of protein localization to nucleus|response to X-ray|epithelial cell maturation|small GTPase mediated signal transduction|cellular protein modification process|protein import into nucleus, translocation|intestinal epithelial cell development|response to corticosteroid|positive regulation of lymphocyte proliferation|DNA biosynthetic process|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|apoptotic process|stress-induced premature senescence|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|positive regulation of kinase activity|positive regulation of mononuclear cell proliferation|neurotrophin TRK receptor signaling pathway|cyclin-dependent protein kinase activating kinase activity|protein serine/threonine kinase inhibitor activity|response to glucocorticoid|regulation of protein targeting|response to UV-B|regulation of G1/S transition of mitotic cell cycle|positive regulation of B cell proliferation|Ras protein signal transduction|nucleocytoplasmic transport|intrinsic apoptotic signaling pathway by p53 class mediator|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|negative regulation of protein kinase activity|protein kinase complex|mitotic G1/S transition checkpoint|protein phosphorylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|G1 DNA damage checkpoint|intestinal epithelial cell maturation|regulation of protein import into nucleus, translocation|regulation of phosphorylation|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|response to mineralocorticoid|negative regulation of phosphorylation|Fc receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|cyclin-dependent protein serine/threonine kinase inhibitor activity|regulation of B cell proliferation|positive regulation of protein phosphorylation|negative regulation of protein phosphorylation|mitotic G1 DNA damage checkpoint|cellular response to UV|positive regulation of phosphorylation|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|protein localization to nucleus|regulation of nucleocytoplasmic transport|signal transduction involved in DNA damage checkpoint|transmembrane receptor protein tyrosine kinase signaling pathway|signal transduction involved in mitotic G1 DNA damage checkpoint|nuclear import|serine/threonine protein kinase complex|Fc-epsilon receptor signaling pathway|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|ERBB signaling pathway|cellular response to UV-B|epidermal growth factor receptor signaling pathway K06625 cyclin-dependent kinase inhibitor 1A[-] hsa05200|hsa04151|hsa05166|hsa05206|hsa05203|hsa05205|hsa05169|hsa05202|hsa04630|hsa04921|hsa05161|hsa04068|hsa05160|hsa04110|hsa04066|hsa05215|hsa04012|hsa05220|hsa05218|hsa04115|hsa05214|hsa05219 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Viral carcinogenesis - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Melanoma - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human)|Glioma - Homo sapiens (human)|Bladder cancer - Homo sapiens (human) 6:36676460-36687339 352 380 800 184 229 252 3.98708416235154 3.91180714801636 8.16991299124036 1.86736463897283 2.12821859139669 2.67511982989544 5.35626810053609 2.22356768675499 1.26835185268568 5.05213129996626e-06 5.45089728331018e-05 UP ENSG00000108602 ALDH3A1 aldehyde dehydrogenase 3 family member A1 [Source:HGNC Symbol;Acc:HGNC:405] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0043227|GO:0071944|GO:0009605|GO:0031224|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0008284|GO:0006081|GO:0042127|GO:0009991|GO:0009410|GO:0044281|GO:0016614|GO:0043231|GO:0010243|GO:0005737|GO:0016903|GO:0042493|GO:0005783|GO:0009725|GO:0006805|GO:0001666|GO:0016021|GO:0010033|GO:0055114|GO:0007568|GO:0007584|GO:0005829|GO:0014074|GO:0033993|GO:0046683|GO:0016616|GO:0016620|GO:0071466|GO:0031981|GO:0005654|GO:0051591|GO:0014070|GO:0031667|GO:0005634|GO:0048545|GO:0004029|GO:0004028|GO:0004030|GO:0004033|GO:0031960|GO:0051384|GO:0008106|GO:0018479 developmental process|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|cell periphery|response to external stimulus|intrinsic component of membrane|extracellular space|intracellular|protein binding|plasma membrane|endomembrane system|positive regulation of cell proliferation|cellular aldehyde metabolic process|regulation of cell proliferation|response to extracellular stimulus|response to xenobiotic stimulus|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|oxidoreductase activity, acting on the aldehyde or oxo group of donors|response to drug|endoplasmic reticulum|response to hormone|xenobiotic metabolic process|response to hypoxia|integral component of membrane|response to organic substance|oxidation-reduction process|aging|response to nutrient|cytosol|response to purine-containing compound|response to lipid|response to organophosphorus|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|cellular response to xenobiotic stimulus|nuclear lumen|nucleoplasm|response to cAMP|response to organic cyclic compound|response to nutrient levels|nucleus|response to steroid hormone|aldehyde dehydrogenase (NAD) activity|3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase [NAD(P)+] activity|aldo-keto reductase (NADP) activity|response to corticosteroid|response to glucocorticoid|alcohol dehydrogenase (NADP+) activity|benzaldehyde dehydrogenase (NAD+) activity K00129 aldehyde dehydrogenase (NAD(P)+)[1.2.1.5] hsa01100|hsa05204|hsa00980|hsa00982|hsa00010|hsa00350 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human)|Tyrosine metabolism - Homo sapiens (human) 17:19737984-19748943 2608 2948 2371 6180 6646 4813 23.249108989442 23.8839584028179 19.0565666673616 49.3611166677451 48.6101619079475 40.2108816656818 22.0632113532072 46.0607200804581 -1.06189417144445 5.0912487057868e-06 5.49111773347396e-05 DOWN ENSG00000247853 RP5-940J5.6 - - - - - - - 12:6578622-6584739 77 62 66 28 27 26 2.48028973603363 1.81503311880797 1.91676590850438 0.808105534963263 0.713574539430927 0.784900241380636 2.07069625444866 0.768860105258275 1.42932291594052 5.12714923241503e-06 5.52784085173414e-05 UP ENSG00000226174 TEX22 testis expressed 22 [Source:HGNC Symbol;Acc:HGNC:40026] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0012505|GO:0031982|GO:0030141|GO:0043231|GO:0005737|GO:0001669|GO:0031410|GO:0016023|GO:0031988 cell|intracellular organelle|membrane-bounded organelle|intracellular|endomembrane system|vesicle|secretory granule|intracellular membrane-bounded organelle|cytoplasm|acrosomal vesicle|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle - - - - 14:105398579-105450106 1 2 2 9 21 16 0.0244867451289321 0.0444894824076605 0.0441370602053381 0.197368724690481 0.421731725650866 0.367028705724669 0.0377044292473102 0.328709718688672 -3.12400819594012 5.18036229381371e-06 5.57916796246445e-05 DOWN ENSG00000136044 APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 [Source:HGNC Symbol;Acc:HGNC:18242] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0007049|GO:0031982|GO:0070603|GO:0043231|GO:0005737|GO:0017053|GO:0007154|GO:0007165|GO:0070062|GO:0010008|GO:0005768|GO:0005769|GO:0031981|GO:0005654|GO:0031901|GO:0000118|GO:0005634|GO:0016581 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|cell cycle|vesicle|SWI/SNF superfamily-type complex|intracellular membrane-bounded organelle|cytoplasm|transcriptional repressor complex|cell communication|signal transduction|extracellular exosome|endosome membrane|endosome|early endosome|nuclear lumen|nucleoplasm|early endosome membrane|histone deacetylase complex|nucleus|NuRD complex - - - - 12:105173296-105236238 75 123 201 335 348 443 0.519867627088047 0.774852384163 1.25615757802524 2.08053388180805 1.97915580568493 2.87782969851543 0.850292529758762 2.3125064620028 -1.44342622878339 5.2001031833213e-06 5.59639078712596e-05 DOWN ENSG00000266490 CTD-2349P21.9 - - - - - - - 17:30792372-30792833 9 6 3 27 30 36 1.37799826192194 0.834900027000902 0.414070956305783 3.70400640969375 3.76870400431697 5.16573355108108 0.875656415076208 4.2128146550306 -2.26634763542277 5.19934611424706e-06 5.59639078712596e-05 DOWN ENSG00000280351 CTD-2561B21.8 - - - - - - - 17:81003335-81005132 6 8 15 30 42 52 0.236040810728026 0.286039163866828 0.532056399206804 1.0574869076713 1.3557338010356 1.91728690775515 0.351378791267219 1.44350253882068 -2.03847462494625 5.26644417123628e-06 5.66574501939055e-05 DOWN ENSG00000139233 LLPH LLP homolog, long-term synaptic facilitation (Aplysia) [Source:HGNC Symbol;Acc:HGNC:28229] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0005730|GO:0003723|GO:0031981|GO:0005634|GO:0044822 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|nucleolus|RNA binding|nuclear lumen|nucleus|poly(A) RNA binding - - - - 12:66116555-66130768 1198 1172 843 605 640 417 9.73494747936665 8.65535206608856 6.17616651257643 4.40483646223872 4.2670217302332 3.17571638636165 8.18882201934388 3.94919152627786 1.05209859510211 5.37110719773152e-06 5.77418200508019e-05 UP ENSG00000153832 FBXO36 F-box protein 36 [Source:HGNC Symbol;Acc:HGNC:27020] GO:0009987|GO:0008152|GO:0005488|GO:0071704|GO:0009056|GO:0044237|GO:0005515|GO:0019538|GO:0030163|GO:0044265|GO:0006508|GO:0044267|GO:0044257|GO:0010498|GO:0051603|GO:0019941|GO:0043161|GO:0006511|GO:0031146 cellular process|metabolic process|binding|organic substance metabolic process|catabolic process|cellular metabolic process|protein binding|protein metabolic process|protein catabolic process|cellular macromolecule catabolic process|proteolysis|cellular protein metabolic process|cellular protein catabolic process|proteasomal protein catabolic process|proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process - - - - 2:229922302-230013109 39 70 124 224 233 262 0.453064271046442 0.739055862298384 1.29878111389904 2.33155890235616 2.22087697360171 2.85252936577839 0.830300415747955 2.46832174724542 -1.57182513714258 5.40836578328135e-06 5.81005225239588e-05 DOWN ENSG00000267745 RP11-686D22.8 - - - - - - - 17:35406684-35409768 0 3 0 13 14 10 0 0.159152088197259 0 0.67980117556339 0.670409618883939 0.546970272712527 0.053050696065753 0.632393689053285 -3.57537938481205 5.4456192146012e-06 5.84796820261526e-05 DOWN ENSG00000159753 RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing [Source:HGNC Symbol;Acc:HGNC:27089] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0051050|GO:0006955|GO:0051641|GO:0048870|GO:0005911|GO:0007155|GO:0071944|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0060341|GO:0008284|GO:0002757|GO:0042127|GO:1903706|GO:0016337|GO:0045595|GO:0070661|GO:0050867|GO:0006810|GO:0007275|GO:0048513|GO:0070489|GO:0032940|GO:0030155|GO:0001817|GO:0098609|GO:0045597|GO:0005737|GO:0001816|GO:0032880|GO:0051222|GO:0006928|GO:0042592|GO:0002696|GO:0001775|GO:0045184|GO:0001772|GO:0001819|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0007163|GO:0008290|GO:0007154|GO:0016477|GO:0007165|GO:0050778|GO:0045785|GO:0051047|GO:0048869|GO:0048732|GO:0051249|GO:0048538|GO:0032943|GO:0007166|GO:0030097|GO:0030098|GO:0032623|GO:0034109|GO:0051223|GO:0015031|GO:0070201|GO:0048872|GO:0050714|GO:0051251|GO:0050715|GO:0002429|GO:0032743|GO:0022407|GO:0051046|GO:0007159|GO:0009306|GO:0002764|GO:0050663|GO:0042110|GO:0032609|GO:0046903|GO:0046651|GO:0030154|GO:0022409|GO:0030011|GO:0050707|GO:0032729|GO:0005856|GO:0032649|GO:0002521|GO:0015629|GO:0042098|GO:0050863|GO:1902715|GO:0030217|GO:0050708|GO:0045619|GO:0002768|GO:0072643|GO:0034112|GO:0070486|GO:1900042|GO:0050870|GO:0050851|GO:0045621|GO:0050671|GO:0070970|GO:1903039|GO:0032946|GO:0045582|GO:0045580|GO:0045066|GO:0050852|GO:0042129|GO:0071593|GO:0042102|GO:0045589|GO:0045591 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|positive regulation of transport|immune response|cellular localization|cell motility|cell-cell junction|cell adhesion|cell periphery|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of cellular localization|positive regulation of cell proliferation|immune response-activating signal transduction|regulation of cell proliferation|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of cell differentiation|leukocyte proliferation|positive regulation of cell activation|transport|multicellular organism development|animal organ development|T cell aggregation|secretion by cell|regulation of cell adhesion|regulation of cytokine production|cell-cell adhesion|positive regulation of cell differentiation|cytoplasm|cytokine production|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|homeostatic process|positive regulation of leukocyte activation|cell activation|establishment of protein localization|immunological synapse|positive regulation of cytokine production|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|establishment or maintenance of cell polarity|F-actin capping protein complex|cell communication|cell migration|signal transduction|positive regulation of immune response|positive regulation of cell adhesion|positive regulation of secretion|cellular developmental process|gland development|regulation of lymphocyte activation|thymus development|mononuclear cell proliferation|cell surface receptor signaling pathway|hemopoiesis|lymphocyte differentiation|interleukin-2 production|homotypic cell-cell adhesion|regulation of protein transport|protein transport|regulation of establishment of protein localization|homeostasis of number of cells|positive regulation of protein secretion|positive regulation of lymphocyte activation|positive regulation of cytokine secretion|immune response-activating cell surface receptor signaling pathway|positive regulation of interleukin-2 production|regulation of cell-cell adhesion|regulation of secretion|leukocyte cell-cell adhesion|protein secretion|immune response-regulating signaling pathway|cytokine secretion|T cell activation|interferon-gamma production|secretion|lymphocyte proliferation|cell differentiation|positive regulation of cell-cell adhesion|maintenance of cell polarity|regulation of cytokine secretion|positive regulation of interferon-gamma production|cytoskeleton|regulation of interferon-gamma production|leukocyte differentiation|actin cytoskeleton|T cell proliferation|regulation of T cell activation|positive regulation of interferon-gamma secretion|T cell differentiation|regulation of protein secretion|regulation of lymphocyte differentiation|immune response-regulating cell surface receptor signaling pathway|interferon-gamma secretion|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|positive regulation of interleukin-2 secretion|positive regulation of T cell activation|antigen receptor-mediated signaling pathway|positive regulation of lymphocyte differentiation|positive regulation of lymphocyte proliferation|interleukin-2 secretion|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|positive regulation of T cell differentiation|regulation of T cell differentiation|regulatory T cell differentiation|T cell receptor signaling pathway|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of T cell proliferation|regulation of regulatory T cell differentiation|positive regulation of regulatory T cell differentiation - - - - 16:67644919-67657569 91 93 51 31 27 15 0.488395478190672 0.453622876935609 0.246781527261137 0.149067545788605 0.118892996099417 0.0754497127592242 0.396266627462473 0.114470084882415 1.79150085253587 5.45610371662115e-06 5.85501510984931e-05 UP ENSG00000232702 RP3-437C15.1 - - - - - - - 6:51410081-51410537 123 100 71 35 44 29 19.0386410039215 14.0672433433412 9.90840605959749 4.85390298451017 5.58791621024459 4.2067793571226 14.3380968022867 4.88286618395912 1.55405339131048 5.45467047316586e-06 5.85501510984931e-05 UP ENSG00000280088 RP11-135F9.3 - - - - - - - 12:100032325-100034074 5 5 11 29 43 26 0.202114825837299 0.183695391458981 0.40087154159256 1.05029295228125 1.4260654174271 0.984937674326786 0.262227252962947 1.15376534801171 -2.13746030348538 5.45894986226348e-06 5.85596439770082e-05 DOWN ENSG00000174145 NWD2 NACHT and WD repeat domain containing 2 [Source:HGNC Symbol;Acc:HGNC:29229] GO:0005488|GO:0005515 binding|protein binding - - - - 4:37244220-37449465 21 19 5 0 2 1 0.178438944544722 0.146725425124347 0.0383011274242281 0 0.0139421422005732 0.00796225169702319 0.121155165697766 0.00730146463253213 4.05252621863073 5.46094375872339e-06 5.85599910103909e-05 UP ENSG00000140470 ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif 17 [Source:HGNC Symbol;Acc:HGNC:17109] GO:0031012|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0005578|GO:0071704|GO:0043167|GO:0016787|GO:0043169|GO:0008233|GO:0019538|GO:0046872|GO:0006508|GO:0008237|GO:0004175|GO:0046914|GO:0008270|GO:0004222 extracellular matrix|extracellular region|metabolic process|binding|catalytic activity|proteinaceous extracellular matrix|organic substance metabolic process|ion binding|hydrolase activity|cation binding|peptidase activity|protein metabolic process|metal ion binding|proteolysis|metallopeptidase activity|endopeptidase activity|transition metal ion binding|zinc ion binding|metalloendopeptidase activity - - - - 15:99971589-100342005 8 10 20 37 55 55 0.0529690633328953 0.0601771993626036 0.119401014690094 0.219507195463336 0.298800206380697 0.341302920179435 0.077515759128531 0.286536774007823 -1.88615875726165 5.53644023861335e-06 5.92843927128992e-05 DOWN ENSG00000105948 TTC26 tetratricopeptide repeat domain 26 [Source:HGNC Symbol;Acc:HGNC:21882] GO:0032502|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0044702|GO:0019953|GO:0051641|GO:0003006|GO:0009653|GO:0016043|GO:0032504|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0048609|GO:0030992|GO:0048468|GO:0006810|GO:0030990|GO:0022607|GO:0006928|GO:0048515|GO:0045184|GO:0072372|GO:0036064|GO:0008104|GO:0007154|GO:0010970|GO:0007276|GO:0007165|GO:0051649|GO:0097542|GO:0030030|GO:0048869|GO:0007017|GO:0007281|GO:0006996|GO:0000902|GO:0005813|GO:0007286|GO:0048232|GO:0007166|GO:0005815|GO:0015031|GO:0044782|GO:0046907|GO:0030031|GO:0007018|GO:0034613|GO:0070925|GO:0042384|GO:0032990|GO:0031503|GO:0030154|GO:0048858|GO:0005856|GO:0060271|GO:0007283|GO:0042073|GO:0007224|GO:0006886|GO:0015630|GO:0030705 developmental process|macromolecular complex|reproduction|signaling|cell|cellular process|reproductive process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|single organism reproductive process|sexual reproduction|cellular localization|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|multicellular organism reproduction|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|intraciliary transport particle B|cell development|transport|intraciliary transport particle|cellular component assembly|movement of cell or subcellular component|spermatid differentiation|establishment of protein localization|primary cilium|ciliary basal body|protein localization|cell communication|establishment of localization by movement along microtubule|gamete generation|signal transduction|establishment of localization in cell|ciliary tip|cell projection organization|cellular developmental process|microtubule-based process|germ cell development|organelle organization|cell morphogenesis|centrosome|spermatid development|male gamete generation|cell surface receptor signaling pathway|microtubule organizing center|protein transport|cilium organization|intracellular transport|cell projection assembly|microtubule-based movement|cellular protein localization|organelle assembly|cilium assembly|cell part morphogenesis|protein complex localization|cell differentiation|cell projection morphogenesis|cytoskeleton|cilium morphogenesis|spermatogenesis|intraciliary transport|smoothened signaling pathway|intracellular protein transport|microtubule cytoskeleton|cytoskeleton-dependent intracellular transport - - - - 7:139133744-139191986 159 233 251 454 590 442 1.01435186380546 1.35091737094887 1.44371006375142 2.59505278772748 3.08825229546707 2.64267373087773 1.26965976616858 2.77532627135743 -1.12821544047127 5.62188695155513e-06 6.01562053948842e-05 DOWN ENSG00000254469 RP11-849H4.2 Putative short transient receptor potential channel 2-like protein [Source:UniProtKB/Swiss-Prot;Acc:Q6ZNB5] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0006139|GO:0003677|GO:0006284|GO:0000012|GO:0006259|GO:0005634|GO:0006974|GO:0003684 cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|DNA binding|base-excision repair|single strand break repair|DNA metabolic process|nucleus|cellular response to DNA damage stimulus|damaged DNA binding - - - - 11:71865509-71928654 10 8 15 39 40 48 0.142120881953315 0.10333502443893 0.192211654766694 0.496635940194592 0.466453896010093 0.639368872540261 0.14588918705298 0.534152902914982 -1.87237981871732 5.64735286051489e-06 6.04070484764642e-05 DOWN ENSG00000198780 FAM169A family with sequence similarity 169 member A [Source:HGNC Symbol;Acc:HGNC:29138] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0005622|GO:0012505|GO:0031090|GO:0019866|GO:0043231|GO:0005635|GO:0031965|GO:0005637|GO:0005634 cell|membrane|intracellular organelle|membrane-bounded organelle|intracellular|endomembrane system|organelle membrane|organelle inner membrane|intracellular membrane-bounded organelle|nuclear envelope|nuclear membrane|nuclear inner membrane|nucleus - - - - 5:74777574-74866951 34 37 28 93 118 88 0.205018639684205 0.202767078815399 0.152222206764491 0.502446072687194 0.583794788693035 0.497302085137091 0.186669308421365 0.527847648839107 -1.4996368450149 5.70540789331036e-06 6.09625079623792e-05 DOWN ENSG00000073331 ALPK1 alpha kinase 1 [Source:HGNC Symbol;Acc:HGNC:20917] GO:0002376|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0006914|GO:0016043|GO:0051707|GO:0009607|GO:0009605|GO:0002682|GO:0016740|GO:0050688|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0033554|GO:0098542|GO:0009615|GO:0000422|GO:0016236|GO:0051607|GO:0000166|GO:0019538|GO:0006996|GO:1903008|GO:0098792|GO:0035639|GO:0000423|GO:0043412|GO:0007005|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0050691|GO:0005524|GO:0030554|GO:0016310|GO:0002230|GO:0004672|GO:0006464|GO:0098779|GO:0006468|GO:0004674 immune system process|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|autophagy|cellular component organization|response to other organism|response to biotic stimulus|response to external stimulus|regulation of immune system process|transferase activity|regulation of defense response to virus|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular response to stress|defense response to other organism|response to virus|mitophagy|macroautophagy|defense response to virus|nucleotide binding|protein metabolic process|organelle organization|organelle disassembly|xenophagy|purine ribonucleoside triphosphate binding|macromitophagy|macromolecule modification|mitochondrion organization|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|regulation of defense response to virus by host|ATP binding|adenyl nucleotide binding|phosphorylation|positive regulation of defense response to virus by host|protein kinase activity|cellular protein modification process|mitophagy in response to mitochondrial depolarization|protein phosphorylation|protein serine/threonine kinase activity - - - - 4:112285509-112442620 48 67 140 220 248 395 0.191405577733227 0.24281411939543 0.503338803454461 0.786027326569667 0.81140207771484 1.47619277926983 0.312519500194373 1.02454072785145 -1.71295921879011 5.71160940124915e-06 6.10069363380652e-05 DOWN ENSG00000161217 PCYT1A phosphate cytidylyltransferase 1, choline, alpha [Source:HGNC Symbol;Acc:HGNC:8754] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0008289|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0042802|GO:0044255|GO:0034641|GO:0044281|GO:0016772|GO:0019637|GO:0043231|GO:0005737|GO:0046983|GO:0006629|GO:0005783|GO:0044249|GO:0005829|GO:0008654|GO:0046486|GO:0006066|GO:0009308|GO:0042587|GO:0046470|GO:0006796|GO:0008610|GO:0016779|GO:0042803|GO:0006644|GO:0006656|GO:0046474|GO:0006576|GO:0006650|GO:0006657|GO:0004105 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|lipid binding|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|identical protein binding|cellular lipid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|lipid metabolic process|endoplasmic reticulum|cellular biosynthetic process|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|alcohol metabolic process|amine metabolic process|glycogen granule|phosphatidylcholine metabolic process|phosphate-containing compound metabolic process|lipid biosynthetic process|nucleotidyltransferase activity|protein homodimerization activity|phospholipid metabolic process|phosphatidylcholine biosynthetic process|glycerophospholipid biosynthetic process|cellular biogenic amine metabolic process|glycerophospholipid metabolic process|CDP-choline pathway|choline-phosphate cytidylyltransferase activity K00968 choline-phosphate cytidylyltransferase[2.7.7.15] hsa01100|hsa05231|hsa00564 Metabolic pathways - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human) 3:196214222-196287957 453 804 673 2979 2879 867 2.87336754724435 4.63477866937658 3.84877399981631 16.930163213205 14.9831333950255 5.15395749202139 3.78564007214575 12.3557513667506 -1.70657358984986 5.75308418619833e-06 6.14279596905454e-05 DOWN ENSG00000120915 EPHX2 epoxide hydrolase 2, cytoplasmic [Source:HGNC Symbol;Acc:HGNC:3402] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0015643|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0016787|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0044255|GO:0006725|GO:1901360|GO:0006082|GO:0009410|GO:0005102|GO:0016788|GO:0044281|GO:0006952|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0042592|GO:0072593|GO:0046983|GO:1903524|GO:0019725|GO:0006629|GO:0070062|GO:0006805|GO:0017144|GO:0008217|GO:0003013|GO:0009636|GO:0005829|GO:0035150|GO:0010468|GO:0046872|GO:0048878|GO:0006066|GO:0006631|GO:0010628|GO:0006954|GO:0055082|GO:0071466|GO:0008202|GO:0006796|GO:0010467|GO:0019216|GO:0019439|GO:0030258|GO:0008015|GO:0045909|GO:0042803|GO:0042578|GO:0006690|GO:0033559|GO:0016311|GO:0046839|GO:0042312|GO:0005777|GO:0000287|GO:0019218|GO:0001676|GO:0019369|GO:0016125|GO:0050801|GO:0016791|GO:0019752|GO:0046272|GO:0055088|GO:0004301|GO:0006873|GO:0050880|GO:0019373|GO:0042577|GO:0042311|GO:0090181|GO:0033885|GO:0008203|GO:0032787|GO:0030003|GO:0055092|GO:0055065|GO:0006875|GO:0042632|GO:0006874|GO:0055074 cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|toxic substance binding|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|intracellular|protein binding|regulation of metabolic process|identical protein binding|cellular lipid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|response to xenobiotic stimulus|receptor binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|defense response|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|homeostatic process|reactive oxygen species metabolic process|protein dimerization activity|positive regulation of blood circulation|cellular homeostasis|lipid metabolic process|extracellular exosome|xenobiotic metabolic process|drug metabolic process|regulation of blood pressure|circulatory system process|response to toxic substance|cytosol|regulation of tube size|regulation of gene expression|metal ion binding|chemical homeostasis|alcohol metabolic process|fatty acid metabolic process|positive regulation of gene expression|inflammatory response|cellular chemical homeostasis|cellular response to xenobiotic stimulus|steroid metabolic process|phosphate-containing compound metabolic process|gene expression|regulation of lipid metabolic process|aromatic compound catabolic process|lipid modification|blood circulation|positive regulation of vasodilation|protein homodimerization activity|phosphoric ester hydrolase activity|icosanoid metabolic process|unsaturated fatty acid metabolic process|dephosphorylation|phospholipid dephosphorylation|regulation of vasodilation|peroxisome|magnesium ion binding|regulation of steroid metabolic process|long-chain fatty acid metabolic process|arachidonic acid metabolic process|sterol metabolic process|ion homeostasis|phosphatase activity|carboxylic acid metabolic process|stilbene catabolic process|lipid homeostasis|epoxide hydrolase activity|cellular ion homeostasis|regulation of blood vessel size|epoxygenase P450 pathway|lipid phosphatase activity|vasodilation|regulation of cholesterol metabolic process|10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity|cholesterol metabolic process|monocarboxylic acid metabolic process|cellular cation homeostasis|sterol homeostasis|metal ion homeostasis|cellular metal ion homeostasis|cholesterol homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis K08726 soluble epoxide hydrolase / lipid-phosphate phosphatase[3.1.3.76] hsa01100|hsa04146|hsa00590 Metabolic pathways - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human) 8:27490779-27545564 1 0 1 14 10 8 0.00908080244098728 0 0.0081797353804497 0.11386268914355 0.0744770679388928 0.0680554959286727 0.00575351260714566 0.0854650843370385 -3.89282022836446 5.76737700900209e-06 6.15585531736677e-05 DOWN ENSG00000144741 SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 [Source:HGNC Symbol;Acc:HGNC:20661] GO:0005215|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0022857|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003735|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0006810|GO:0034641|GO:0043231|GO:0005737|GO:0031966|GO:0022891|GO:0055085|GO:0005337|GO:0016021|GO:0044249|GO:0019538|GO:1901642|GO:0005740|GO:0034645|GO:0006518|GO:1903825|GO:0051181|GO:0006811|GO:0005743|GO:0015211|GO:0005739|GO:0000095|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:1901264|GO:0015932|GO:0034220|GO:0015858|GO:0015805|GO:0043043|GO:0006820|GO:0015711|GO:0098656|GO:0015860|GO:0046942|GO:0006412|GO:0006865|GO:0003333|GO:1901962 transporter activity|structural molecule activity|cell|membrane|cellular process|metabolic process|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|transport|cellular nitrogen compound metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|substrate-specific transmembrane transporter activity|transmembrane transport|nucleoside transmembrane transporter activity|integral component of membrane|cellular biosynthetic process|protein metabolic process|nucleoside transmembrane transport|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|organic acid transmembrane transport|cofactor transport|ion transport|mitochondrial inner membrane|purine nucleoside transmembrane transporter activity|mitochondrion|S-adenosyl-L-methionine transmembrane transporter activity|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|carbohydrate derivative transport|nucleobase-containing compound transmembrane transporter activity|ion transmembrane transport|nucleoside transport|S-adenosyl-L-methionine transport|peptide biosynthetic process|anion transport|organic anion transport|anion transmembrane transport|purine nucleoside transmembrane transport|carboxylic acid transport|translation|amino acid transport|amino acid transmembrane transport|S-adenosyl-L-methionine transmembrane transport - - - - 3:66133610-66388116 42 42 96 210 185 156 0.406032822976729 0.369012804061899 0.836758165228512 1.81898731993317 1.46741115145422 1.4133996966559 0.537267930755713 1.56659938934776 -1.54392266912123 5.85023672033675e-06 6.24206458359304e-05 DOWN ENSG00000279821 RP11-1334A24.5 - - - - - - - 5:177476631-177479656 40 49 65 22 19 13 0.935054540589689 1.04101395457114 1.36995150603297 0.460778135868578 0.364420473665311 0.284816828622319 1.11534000039793 0.370005146052069 1.59186632746907 5.9370116813735e-06 6.33012666913301e-05 UP ENSG00000196110 ZNF699 zinc finger protein 699 [Source:HGNC Symbol;Acc:HGNC:24750] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:9294275-9309838 49 68 126 22 20 34 0.623289019390817 0.7861061933783 1.44503404181347 0.250730918744528 0.208728908388177 0.405322317900382 0.951476418194196 0.288260715011029 1.72279366490895 5.94232473937363e-06 6.33352955263336e-05 UP ENSG00000136155 SCEL sciellin [Source:HGNC Symbol;Acc:HGNC:10573] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0043167|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0009888|GO:0007275|GO:0048513|GO:0001533|GO:0031982|GO:0043169|GO:0005737|GO:0070062|GO:0048869|GO:0046872|GO:0009790|GO:0043588|GO:0060429|GO:0030154|GO:0030855|GO:0030216|GO:0008544|GO:0046914|GO:0008270|GO:0009913 developmental process|cell|membrane|cellular process|extracellular region|binding|extracellular vesicle|ion binding|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|tissue development|multicellular organism development|animal organ development|cornified envelope|vesicle|cation binding|cytoplasm|extracellular exosome|cellular developmental process|metal ion binding|embryo development|skin development|epithelium development|cell differentiation|epithelial cell differentiation|keratinocyte differentiation|epidermis development|transition metal ion binding|zinc ion binding|epidermal cell differentiation - - - - 13:77535674-77645263 178 200 443 728 837 606 2.11119559914713 2.15584514014318 4.73725288008549 7.73637187469594 8.14519444687091 6.73612322349532 3.0014312064586 7.53922984835406 -1.3287665546073 6.13653395081084e-06 6.53352655376272e-05 DOWN ENSG00000164051 CCDC51 coiled-coil domain containing 51 [Source:HGNC Symbol;Acc:HGNC:25714] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0043231|GO:0005737|GO:0016021|GO:0031981|GO:0005654|GO:0005739|GO:0005634 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|intracellular membrane-bounded organelle|cytoplasm|integral component of membrane|nuclear lumen|nucleoplasm|mitochondrion|nucleus - - - - 3:48432164-48440456 774 806 622 432 437 289 10.65388122941 10.082822791408 7.71919578062848 5.32781293465343 4.93533832277925 3.72815294486752 9.48529993381549 4.6637680674334 1.02419734963586 6.15125222687572e-06 6.54686217401596e-05 UP ENSG00000164494 PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 [Source:HGNC Symbol;Acc:HGNC:23041] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0044255|GO:0044281|GO:0022607|GO:0043231|GO:0005737|GO:0046983|GO:0051186|GO:0006629|GO:0042180|GO:0016765|GO:0044249|GO:0050878|GO:0046982|GO:0006720|GO:0050347|GO:1990234|GO:0008299|GO:0005759|GO:0005739|GO:0006461|GO:0008610|GO:1901661|GO:0000010|GO:0051259|GO:0009108|GO:0006743|GO:0051291|GO:0006744|GO:0051262|GO:0051290 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|cellular lipid metabolic process|small molecule metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|cofactor metabolic process|lipid metabolic process|cellular ketone metabolic process|transferase activity, transferring alkyl or aryl (other than methyl) groups|cellular biosynthetic process|regulation of body fluid levels|protein heterodimerization activity|isoprenoid metabolic process|trans-octaprenyltranstransferase activity|transferase complex|isoprenoid biosynthetic process|mitochondrial matrix|mitochondrion|protein complex assembly|lipid biosynthetic process|quinone metabolic process|trans-hexaprenyltranstransferase activity|protein oligomerization|coenzyme biosynthetic process|ubiquinone metabolic process|protein heterooligomerization|ubiquinone biosynthetic process|protein tetramerization|protein heterotetramerization K12505 decaprenyl-diphosphate synthase subunit 2[2.5.1.91] hsa00900 Terpenoid backbone biosynthesis - Homo sapiens (human) 6:107152557-107459564 120 104 187 317 354 344 1.86517800911298 1.46910116814397 2.62056588789137 4.41464667878271 4.51450010953065 5.01102781733718 1.98494835504944 4.64672486855018 -1.22711275434794 6.20317749541846e-06 6.59977408938784e-05 DOWN ENSG00000116990 MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog [Source:HGNC Symbol;Acc:HGNC:7555] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0048839|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0007423|GO:0046983|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0045682|GO:0010468|GO:0034645|GO:0060113|GO:0043583|GO:0051252|GO:0030856|GO:0060429|GO:0010467|GO:0007399|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0051960|GO:0030182|GO:0030855|GO:0032774|GO:2001141|GO:0008544|GO:0045604|GO:0042491|GO:0022008|GO:0050767|GO:0006351|GO:0006355|GO:0045607|GO:0048699|GO:1903506|GO:0035315|GO:0042490|GO:0045664|GO:0009913|GO:0060563 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|inner ear development|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|sensory organ development|protein dimerization activity|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of epidermis development|regulation of gene expression|cellular macromolecule biosynthetic process|inner ear receptor cell differentiation|ear development|regulation of RNA metabolic process|regulation of epithelial cell differentiation|epithelium development|gene expression|nervous system development|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|regulation of nervous system development|neuron differentiation|epithelial cell differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|epidermis development|regulation of epidermal cell differentiation|auditory receptor cell differentiation|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of auditory receptor cell differentiation|generation of neurons|regulation of nucleic acid-templated transcription|hair cell differentiation|mechanoreceptor differentiation|regulation of neuron differentiation|epidermal cell differentiation|neuroepithelial cell differentiation - - - - 1:39895426-39902256 49 53 95 18 23 28 0.473900770690776 0.465854174849406 0.828376821001291 0.155973643520779 0.182509300102649 0.25378895554106 0.589377255513824 0.197423966388163 1.57789424974866 6.2689106150628e-06 6.66495931275231e-05 UP ENSG00000162174 ASRGL1 asparaginase like 1 [Source:HGNC Symbol;Acc:HGNC:16448] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0043231|GO:0008233|GO:0005737|GO:0006520|GO:0016810|GO:0019538|GO:0005829|GO:0016811|GO:0009072|GO:0009063|GO:0006508|GO:0043603|GO:0019439|GO:0005634|GO:0006528|GO:0009074|GO:0006558|GO:0004067|GO:0046395|GO:0008238|GO:0019752|GO:0008242|GO:0006559|GO:0008798|GO:0033345 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|cellular amino acid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|protein metabolic process|cytosol|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|aromatic amino acid family metabolic process|cellular amino acid catabolic process|proteolysis|cellular amide metabolic process|aromatic compound catabolic process|nucleus|asparagine metabolic process|aromatic amino acid family catabolic process|L-phenylalanine metabolic process|asparaginase activity|carboxylic acid catabolic process|exopeptidase activity|carboxylic acid metabolic process|omega peptidase activity|L-phenylalanine catabolic process|beta-aspartyl-peptidase activity|asparagine catabolic process via L-aspartate - - - - 11:62337448-62393412 43 63 60 141 151 143 0.340845905327582 0.453846980685707 0.428800579499 1.00139082088856 0.982044988520457 1.06231066492274 0.407831155170763 1.01524882477725 -1.31578946173345 6.27946462933931e-06 6.6738033835634e-05 DOWN ENSG00000141441 GAREM GRB2 associated regulator of MAPK1 subtype 1 [Source:HGNC Symbol;Acc:HGNC:26136] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0071704|GO:0044237|GO:0023051|GO:0071944|GO:0009893|GO:0005515|GO:0005886|GO:0019222|GO:0008284|GO:0042127|GO:0070849|GO:0070064|GO:0051302|GO:0031325|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0051781|GO:0051301|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0007166|GO:0043412|GO:0036211|GO:0071364|GO:0051247|GO:0070848|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:0051246|GO:1902531|GO:0031401|GO:0043408|GO:0071363|GO:0016310|GO:0070371|GO:0007167|GO:0043410|GO:0006464|GO:0006468|GO:0042325|GO:0070374|GO:0001932|GO:0001934|GO:0070372|GO:0042327|GO:0007169|GO:0038127|GO:0007173 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|organic substance metabolic process|cellular metabolic process|regulation of signaling|cell periphery|positive regulation of metabolic process|protein binding|plasma membrane|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|response to epidermal growth factor|proline-rich region binding|regulation of cell division|positive regulation of cellular metabolic process|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|positive regulation of cell division|cell division|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell surface receptor signaling pathway|macromolecule modification|protein modification process|cellular response to epidermal growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of protein metabolic process|regulation of intracellular signal transduction|positive regulation of protein modification process|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|ERK1 and ERK2 cascade|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|cellular protein modification process|protein phosphorylation|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 18:32124877-32470484 131 180 300 466 483 614 0.990860504959095 1.23735183642349 2.04586701887702 3.1580893309872 2.99748178813774 4.35249410478484 1.42469312008653 3.50268840796993 -1.29781145943297 6.29156272372682e-06 6.68428162114379e-05 DOWN ENSG00000225302 RP11-539I5.1 - - - - - - - 10:116828761-116850205 12 22 20 82 76 43 0.167860197019355 0.279675824745804 0.25223670949857 1.02769182501964 0.87223399088313 0.563701727307472 0.23325757708791 0.821209181070081 -1.81582581075482 6.29447846525877e-06 6.68500035936803e-05 DOWN ENSG00000081087 OSTM1 osteopetrosis associated transmembrane protein 1 [Source:HGNC Symbol;Acc:HGNC:21652] GO:0032502|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0031090|GO:0006810|GO:0007275|GO:0048513|GO:0043231|GO:0005774|GO:0005737|GO:0055085|GO:0048869|GO:0016021|GO:0005829|GO:0030097|GO:0005773|GO:0006811|GO:0030154|GO:0005634|GO:0034220|GO:0002521|GO:0000323|GO:0030099|GO:0005765|GO:0002573|GO:0005764|GO:0030316 developmental process|immune system process|cell|membrane|cellular process|binding|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|immune system development|protein binding|anatomical structure development|organelle membrane|transport|multicellular organism development|animal organ development|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|transmembrane transport|cellular developmental process|integral component of membrane|cytosol|hemopoiesis|vacuole|ion transport|cell differentiation|nucleus|ion transmembrane transport|leukocyte differentiation|lytic vacuole|myeloid cell differentiation|lysosomal membrane|myeloid leukocyte differentiation|lysosome|osteoclast differentiation - - - - 6:108041409-108165854 141 150 169 308 462 335 1.11130131841872 1.07443958906523 1.20091258159919 2.17500405802614 2.98759275716246 2.47448973499183 1.12888449636105 2.54569551672681 -1.1731619909887 6.3381671137944e-06 6.72661361589826e-05 DOWN ENSG00000172478 C2orf54 chromosome 2 open reading frame 54 [Source:HGNC Symbol;Acc:HGNC:26216] - - - - - - 2:240886048-240896889 78 70 134 256 264 223 1.03478675051622 0.843981835246599 1.60278670714524 3.04293345900999 2.87360582304776 2.77260965017659 1.16051843096935 2.89638297741145 -1.31948294169682 6.4196089017217e-06 6.81062559175549e-05 DOWN ENSG00000004866 ST7 suppression of tumorigenicity 7 [Source:HGNC Symbol;Acc:HGNC:11351] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 7:116953238-117230103 123 184 128 418 502 278 0.678149566546542 0.921969102303101 0.636273609549347 2.06487129654624 2.27086407139325 1.43645863349719 0.745464092799663 1.92406466714556 -1.3679465202343 6.51601953442501e-06 6.89540010423044e-05 DOWN ENSG00000184454 NCMAP non-compact myelin associated protein [Source:HGNC Symbol;Acc:HGNC:29332] GO:0032502|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0042995|GO:0043218|GO:0043220|GO:0050794|GO:0043209|GO:0009653|GO:0016043|GO:0071944|GO:0031224|GO:0019911|GO:0050793|GO:0005886|GO:0048856|GO:0048646|GO:0048468|GO:0031643|GO:0031641|GO:0007275|GO:0050877|GO:0022607|GO:0005887|GO:0043005|GO:0031226|GO:0048869|GO:0016021|GO:0033270|GO:0030424|GO:0021782|GO:0044304|GO:0031644|GO:0032288|GO:0007399|GO:0030154|GO:0051960|GO:0008366|GO:0007422|GO:0014044|GO:0010001|GO:0032290|GO:0042552|GO:0022008|GO:0014037|GO:0022011|GO:0042063 developmental process|structural molecule activity|cell|membrane|cellular process|cell projection|compact myelin|Schmidt-Lanterman incisure|regulation of cellular process|myelin sheath|anatomical structure morphogenesis|cellular component organization|cell periphery|intrinsic component of membrane|structural constituent of myelin sheath|regulation of developmental process|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|cell development|positive regulation of myelination|regulation of myelination|multicellular organism development|neurological system process|cellular component assembly|integral component of plasma membrane|neuron projection|intrinsic component of plasma membrane|cellular developmental process|integral component of membrane|paranode region of axon|axon|glial cell development|main axon|regulation of neurological system process|myelin assembly|nervous system development|cell differentiation|regulation of nervous system development|axon ensheathment|peripheral nervous system development|Schwann cell development|glial cell differentiation|peripheral nervous system myelin formation|myelination|neurogenesis|Schwann cell differentiation|myelination in peripheral nervous system|gliogenesis - - - - 1:24556111-24609328 4 3 9 19 30 45 0.0356744738106998 0.0243213126837824 0.072370330827582 0.151835095249507 0.21953615559128 0.37614564692338 0.0441220391073547 0.249172299254722 -2.49757231938561 6.53102580708304e-06 6.90673908766054e-05 DOWN ENSG00000176845 METRNL meteorin, glial cell differentiation regulator-like [Source:HGNC Symbol;Acc:HGNC:27584] GO:0032502|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0014823|GO:0050794|GO:0006950|GO:0009628|GO:0043227|GO:0009605|GO:0005615|GO:0050793|GO:0005515|GO:0045595|GO:0014850|GO:0005102|GO:2000505|GO:0006952|GO:0031982|GO:0045597|GO:2000507|GO:0009611|GO:0042592|GO:0048871|GO:0070062|GO:0009409|GO:0048869|GO:0009266|GO:0050727|GO:0005179|GO:0006954|GO:0045600|GO:0050728|GO:0097009|GO:0045598|GO:0030154|GO:0045444|GO:0090335|GO:0090336|GO:0050873 developmental process|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|response to activity|regulation of cellular process|response to stress|response to abiotic stimulus|membrane-bounded organelle|response to external stimulus|extracellular space|regulation of developmental process|protein binding|regulation of cell differentiation|response to muscle activity|receptor binding|regulation of energy homeostasis|defense response|vesicle|positive regulation of cell differentiation|positive regulation of energy homeostasis|response to wounding|homeostatic process|multicellular organismal homeostasis|extracellular exosome|response to cold|cellular developmental process|response to temperature stimulus|regulation of inflammatory response|hormone activity|inflammatory response|positive regulation of fat cell differentiation|negative regulation of inflammatory response|energy homeostasis|regulation of fat cell differentiation|cell differentiation|fat cell differentiation|regulation of brown fat cell differentiation|positive regulation of brown fat cell differentiation|brown fat cell differentiation - - - - 17:83079691-83095119 169 166 343 508 585 606 2.46485265078464 2.20034889590217 4.51037205646721 6.63842950817882 7.00048279524021 8.28334822781981 3.05852453438467 7.30742017707961 -1.25652631587248 6.54066313497268e-06 6.91448148836666e-05 DOWN ENSG00000173581 CCDC106 coiled-coil domain containing 106 [Source:HGNC Symbol;Acc:HGNC:30181] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005730|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nucleolus|nuclear lumen|nucleoplasm|nucleus - - - - 19:55641062-55653161 217 186 133 80 72 73 2.75482392313626 2.1459867528189 1.52229850974961 0.909956183401048 0.74995524484143 0.868538058744982 2.14103639523492 0.842816495662487 1.34501886407042 6.55593009957231e-06 6.92571610731181e-05 UP ENSG00000197191 CYSRT1 cysteine-rich tail protein 1 [Source:HGNC Symbol;Acc:HGNC:30529] - - - - - - 9:137224635-137226311 145 162 206 375 460 343 7.9081446296073 8.02971699060081 10.1294872548607 18.3246092906033 20.5840991994706 17.5318668732254 8.6891162916896 18.8135251210998 -1.11448883098256 6.5883285569708e-06 6.95748004031858e-05 DOWN ENSG00000185989 RASA3 RAS p21 protein activator 3 [Source:HGNC Symbol;Acc:HGNC:20331] GO:0040011|GO:0032502|GO:0004871|GO:0005215|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0022857|GO:0048523|GO:0050794|GO:0006950|GO:0005057|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0038023|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0031224|GO:0030234|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0009898|GO:0006935|GO:0045087|GO:0048468|GO:0006810|GO:0007275|GO:0008047|GO:0006952|GO:0031325|GO:0015278|GO:0043169|GO:0010243|GO:0004888|GO:0005737|GO:0006928|GO:0098562|GO:0009966|GO:0022891|GO:0010646|GO:0031226|GO:0043085|GO:0050776|GO:0007154|GO:0055085|GO:0007165|GO:0009968|GO:0009725|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0005096|GO:0046872|GO:0007166|GO:0043412|GO:0051345|GO:0030695|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0015267|GO:0031235|GO:0006811|GO:0015075|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:1902532|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0034220|GO:0048666|GO:0030182|GO:0007411|GO:0015276|GO:0098655|GO:0005216|GO:0031401|GO:0008543|GO:1901653|GO:0043408|GO:0006812|GO:0071363|GO:0043087|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0043547|GO:0007167|GO:0071375|GO:0043410|GO:0032868|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0051058|GO:0048812|GO:0043549|GO:0008324|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0022890|GO:0030001|GO:0001934|GO:0005261|GO:0042327|GO:0046580|GO:0007169|GO:0048010|GO:0005262|GO:0070588|GO:0038095|GO:0071900|GO:0046873|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0006816|GO:0015085 locomotion|developmental process|signal transducer activity|transporter activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|transmembrane transporter activity|negative regulation of cellular process|regulation of cellular process|response to stress|receptor signaling protein activity|organic substance metabolic process|ion binding|immune response|cellular metabolic process|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|enzyme regulator activity|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|cytoplasmic side of plasma membrane|chemotaxis|innate immune response|cell development|transport|multicellular organism development|enzyme activator activity|defense response|positive regulation of cellular metabolic process|calcium-release channel activity|cation binding|response to organonitrogen compound|transmembrane signaling receptor activity|cytoplasm|movement of cell or subcellular component|cytoplasmic side of membrane|regulation of signal transduction|substrate-specific transmembrane transporter activity|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|regulation of immune response|cell communication|transmembrane transport|signal transduction|negative regulation of signal transduction|response to hormone|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|GTPase activator activity|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|positive regulation of hydrolase activity|GTPase regulator activity|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|channel activity|intrinsic component of the cytoplasmic side of the plasma membrane|ion transport|ion transmembrane transporter activity|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|ion transmembrane transport|neuron development|neuron differentiation|axon guidance|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular response to peptide|regulation of MAPK cascade|cation transport|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|response to insulin|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|negative regulation of small GTPase mediated signal transduction|neuron projection morphogenesis|regulation of kinase activity|cation transmembrane transporter activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|inorganic cation transmembrane transporter activity|metal ion transport|positive regulation of protein phosphorylation|cation channel activity|positive regulation of phosphorylation|negative regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|calcium channel activity|calcium ion transmembrane transport|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|metal ion transmembrane transporter activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|calcium ion transport|calcium ion transmembrane transporter activity - - - - 13:113977783-114132611 110 131 270 389 464 554 1.55247869693588 1.68030067777653 3.43567573835524 4.91906428300242 5.37304735222524 7.32779060814684 2.22281837102255 5.8733007477915 -1.40178144530534 6.60415396364337e-06 6.96926166244642e-05 DOWN ENSG00000135905 DOCK10 dedicator of cytokinesis 10 [Source:HGNC Symbol;Acc:HGNC:23479] GO:0040011|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0040012|GO:0048870|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0019222|GO:0031982|GO:0006928|GO:0043085|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0070062|GO:0050790|GO:2000145|GO:0051345|GO:0030334|GO:0035556|GO:0043087|GO:0043547|GO:0007264 locomotion|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|regulation of locomotion|cell motility|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|regulation of metabolic process|vesicle|movement of cell or subcellular component|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|cell migration|signal transduction|extracellular exosome|regulation of catalytic activity|regulation of cell motility|positive regulation of hydrolase activity|regulation of cell migration|intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase mediated signal transduction - - - - 2:224765090-225042445 621 844 709 1968 2301 1124 3.38790402203855 4.18467868302101 3.48738784277954 9.61971973841244 10.2996938372245 5.74691936852989 3.6866568492797 8.55544431472228 -1.21452964303921 6.62116793832685e-06 6.98474726610636e-05 DOWN ENSG00000114279 FGF12 fibroblast growth factor 12 [Source:HGNC Symbol;Acc:HGNC:3668] GO:0032502|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0051051|GO:0044237|GO:0043227|GO:0044708|GO:0005615|GO:0016247|GO:0005622|GO:0005515|GO:0007626|GO:0048856|GO:0007507|GO:0008201|GO:0008344|GO:0042391|GO:0030534|GO:0044325|GO:0006810|GO:0007275|GO:0048513|GO:0050877|GO:0005102|GO:0043168|GO:0043270|GO:0033554|GO:0043231|GO:0003012|GO:0007267|GO:0003254|GO:0006928|GO:0042592|GO:0007154|GO:0044092|GO:0055085|GO:0007165|GO:2000021|GO:0017080|GO:0032410|GO:0030029|GO:0019538|GO:0023014|GO:0005539|GO:0010033|GO:0003013|GO:0034763|GO:0043271|GO:0071774|GO:0000165|GO:0050905|GO:0006936|GO:0007166|GO:0051899|GO:0043412|GO:0072358|GO:0048878|GO:0030048|GO:0001508|GO:0036211|GO:0006811|GO:0032413|GO:0031098|GO:0044344|GO:0034766|GO:0070848|GO:0034765|GO:0043269|GO:0006796|GO:0035556|GO:0044267|GO:0010765|GO:0007399|GO:0071310|GO:0008083|GO:0072359|GO:0008015|GO:0005634|GO:0022898|GO:0034220|GO:0006941|GO:0098655|GO:0070252|GO:0086001|GO:0008543|GO:2001258|GO:0060047|GO:0006812|GO:0071363|GO:0016310|GO:0032412|GO:0007167|GO:0050801|GO:0006464|GO:0051403|GO:0086003|GO:0006468|GO:0086002|GO:0060048|GO:0007254|GO:0002028|GO:1902305|GO:0030001|GO:2000649|GO:2001257|GO:0015672|GO:0007268|GO:0007169|GO:0035725|GO:0006814 developmental process|behavior|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|negative regulation of transport|cellular metabolic process|membrane-bounded organelle|single-organism behavior|extracellular space|channel regulator activity|intracellular|protein binding|locomotory behavior|anatomical structure development|heart development|heparin binding|adult locomotory behavior|regulation of membrane potential|adult behavior|ion channel binding|transport|multicellular organism development|animal organ development|neurological system process|receptor binding|anion binding|positive regulation of ion transport|cellular response to stress|intracellular membrane-bounded organelle|muscle system process|cell-cell signaling|regulation of membrane depolarization|movement of cell or subcellular component|homeostatic process|cell communication|negative regulation of molecular function|transmembrane transport|signal transduction|regulation of ion homeostasis|sodium channel regulator activity|negative regulation of transporter activity|actin filament-based process|protein metabolic process|signal transduction by protein phosphorylation|glycosaminoglycan binding|response to organic substance|circulatory system process|negative regulation of transmembrane transport|negative regulation of ion transport|response to fibroblast growth factor|MAPK cascade|neuromuscular process|muscle contraction|cell surface receptor signaling pathway|membrane depolarization|macromolecule modification|cardiovascular system development|chemical homeostasis|actin filament-based movement|action potential|protein modification process|ion transport|negative regulation of ion transmembrane transporter activity|stress-activated protein kinase signaling cascade|cellular response to fibroblast growth factor stimulus|negative regulation of ion transmembrane transport|response to growth factor|regulation of ion transmembrane transport|regulation of ion transport|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|positive regulation of sodium ion transport|nervous system development|cellular response to organic substance|growth factor activity|circulatory system development|blood circulation|nucleus|regulation of transmembrane transporter activity|ion transmembrane transport|striated muscle contraction|cation transmembrane transport|actin-mediated cell contraction|cardiac muscle cell action potential|fibroblast growth factor receptor signaling pathway|negative regulation of cation channel activity|heart contraction|cation transport|cellular response to growth factor stimulus|phosphorylation|regulation of ion transmembrane transporter activity|enzyme linked receptor protein signaling pathway|ion homeostasis|cellular protein modification process|stress-activated MAPK cascade|cardiac muscle cell contraction|protein phosphorylation|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|JNK cascade|regulation of sodium ion transport|regulation of sodium ion transmembrane transport|metal ion transport|regulation of sodium ion transmembrane transporter activity|regulation of cation channel activity|monovalent inorganic cation transport|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|sodium ion transmembrane transport|sodium ion transport K04358 fibroblast growth factor[-] hsa05200|hsa04151|hsa04010|hsa04014|hsa04810|hsa04015|hsa05218 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Melanoma - Homo sapiens (human) 3:192139395-192767764 0 2 2 22 15 8 0 0.0122908521325054 0.0121934904878527 0.133286936156994 0.0832233711568384 0.0506984494572361 0.00816144754011937 0.0890695855903562 -3.44803592075143 6.69067524073794e-06 7.04810933793191e-05 DOWN ENSG00000128242 GAL3ST1 galactose-3-O-sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:24240] GO:0032502|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0043227|GO:0071944|GO:0032504|GO:0009058|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0048609|GO:0006486|GO:0044255|GO:0007275|GO:0034641|GO:0005887|GO:0043231|GO:0005737|GO:0005975|GO:0031226|GO:0007276|GO:0006629|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0006665|GO:0048232|GO:0043412|GO:0006487|GO:0006643|GO:0009100|GO:0036211|GO:0070085|GO:0043603|GO:1901137|GO:0044267|GO:0008146|GO:0008610|GO:0007399|GO:0000139|GO:0009059|GO:0008366|GO:0007283|GO:0009101|GO:0006672|GO:0043413|GO:0006687|GO:0009247|GO:0006664|GO:0050694|GO:0042552|GO:0030148|GO:0006464|GO:0046513|GO:0006688|GO:0006677|GO:0001733|GO:0006682|GO:0006681 developmental process|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|membrane-bounded organelle|cell periphery|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|transferase activity|anatomical structure development|organelle membrane|multicellular organismal reproductive process|protein glycosylation|cellular lipid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|intrinsic component of plasma membrane|gamete generation|lipid metabolic process|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|sphingolipid metabolic process|male gamete generation|macromolecule modification|protein N-linked glycosylation|membrane lipid metabolic process|glycoprotein metabolic process|protein modification process|glycosylation|cellular amide metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|sulfotransferase activity|lipid biosynthetic process|nervous system development|Golgi membrane|macromolecule biosynthetic process|axon ensheathment|spermatogenesis|glycoprotein biosynthetic process|ceramide metabolic process|macromolecule glycosylation|glycosphingolipid metabolic process|glycolipid biosynthetic process|glycolipid metabolic process|galactose 3-O-sulfotransferase activity|myelination|sphingolipid biosynthetic process|cellular protein modification process|ceramide biosynthetic process|glycosphingolipid biosynthetic process|glycosylceramide metabolic process|galactosylceramide sulfotransferase activity|galactosylceramide biosynthetic process|galactosylceramide metabolic process K01019 galactosylceramide sulfotransferase[2.8.2.11] hsa01100|hsa00600|hsa00565 Metabolic pathways - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human)|Ether lipid metabolism - Homo sapiens (human) 22:30554635-30574587 20 18 17 1 6 4 0.11107305644282 0.0908511766839327 0.0851215757059952 0.00497360394918835 0.0273380703037854 0.0208167528861484 0.0956819362775826 0.0177094757130407 2.43372508317768 6.71235960063951e-06 7.0684579723983e-05 UP ENSG00000265018 CTGLF12P ArfGAP with GTPase domain, ankyrin repeat and PH domain 12, pseudogene [Source:HGNC Symbol;Acc:HGNC:23661] - - - - - - 10:48009873-48031640 6 17 20 52 57 50 0.102561956908891 0.26411661672355 0.308255447059998 0.796441783260347 0.799456485883218 0.801041655241256 0.22497800689748 0.79897997479494 -1.82837536941143 6.75356351695701e-06 7.10683416409005e-05 DOWN ENSG00000123600 METTL8 methyltransferase like 8 [Source:HGNC Symbol;Acc:HGNC:25856] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0032259|GO:0043229|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0016740|GO:0048856|GO:0009888|GO:0007275|GO:0016570|GO:0048513|GO:0061061|GO:0043231|GO:0016746|GO:0005737|GO:0048869|GO:0019538|GO:0006996|GO:0051276|GO:0008168|GO:0043412|GO:0006325|GO:0016573|GO:0036211|GO:0060537|GO:0016747|GO:0044267|GO:0030154|GO:0007517|GO:0005634|GO:0060538|GO:0045444|GO:0016407|GO:0016410|GO:0016568|GO:0014706|GO:0006464|GO:0007519|GO:0018193|GO:0008080|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393|GO:0004402 developmental process|cell|cellular process|metabolic process|catalytic activity|methylation|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|transferase activity|anatomical structure development|tissue development|multicellular organism development|histone modification|animal organ development|muscle structure development|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|cellular developmental process|protein metabolic process|organelle organization|chromosome organization|methyltransferase activity|macromolecule modification|chromatin organization|histone acetylation|protein modification process|muscle tissue development|transferase activity, transferring acyl groups other than amino-acyl groups|cellular protein metabolic process|cell differentiation|muscle organ development|nucleus|skeletal muscle organ development|fat cell differentiation|acetyltransferase activity|N-acyltransferase activity|chromatin modification|striated muscle tissue development|cellular protein modification process|skeletal muscle tissue development|peptidyl-amino acid modification|N-acetyltransferase activity|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity - - - - 2:171317405-171434802 102 121 126 304 305 235 0.311575537654157 0.335915445706494 0.34701534337456 0.832022196759395 0.764417342279583 0.672760920359934 0.331502108911737 0.756400153132971 -1.19013160702352 6.79848241459543e-06 7.15158188884185e-05 DOWN ENSG00000020922 MRE11A MRE11 homolog A, double strand break repair nuclease [Source:HGNC Symbol;Acc:HGNC:7230] GO:0040011|GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0040013|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0007507|GO:0051726|GO:0007049|GO:0007131|GO:0006281|GO:0045087|GO:0006725|GO:0008022|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0030870|GO:0016788|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0016817|GO:0001817|GO:0045786|GO:0043231|GO:0000723|GO:0043169|GO:0046597|GO:0005737|GO:0001816|GO:0042592|GO:0046596|GO:0009890|GO:0070192|GO:0001819|GO:0006139|GO:0043085|GO:0000790|GO:0007126|GO:0048525|GO:0050790|GO:0007059|GO:0044249|GO:0019538|GO:0050792|GO:0031324|GO:0031323|GO:0006996|GO:0051701|GO:0051276|GO:0032268|GO:0005829|GO:0003677|GO:0007004|GO:0000819|GO:0000075|GO:0034645|GO:0051053|GO:0032479|GO:0046872|GO:0000725|GO:0010833|GO:1903047|GO:0043412|GO:0072358|GO:0044770|GO:0007129|GO:0032481|GO:0006302|GO:0016818|GO:0051347|GO:0036211|GO:0000278|GO:0007127|GO:0035861|GO:0031981|GO:0004518|GO:0045132|GO:0007062|GO:0007346|GO:0010564|GO:0032606|GO:0051247|GO:0045930|GO:0048471|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0019058|GO:0051246|GO:0009059|GO:0072359|GO:0005634|GO:0006974|GO:0010948|GO:0006303|GO:0000724|GO:0008156|GO:0031401|GO:0032200|GO:0006260|GO:0000781|GO:0004536|GO:0007093|GO:0000086|GO:0046718|GO:0000793|GO:0044772|GO:0016310|GO:0044774|GO:0000077|GO:0016604|GO:0032876|GO:0003690|GO:1901990|GO:0000794|GO:0004527|GO:0045143|GO:0042023|GO:0000018|GO:0006275|GO:0006310|GO:0004519|GO:0000784|GO:0046914|GO:0032875|GO:0007095|GO:1901987|GO:0090305|GO:0030260|GO:0006464|GO:0071103|GO:0016462|GO:0043549|GO:0044773|GO:1901991|GO:0033674|GO:0004520|GO:0006278|GO:0010389|GO:0044818|GO:0010972|GO:0006261|GO:0030145|GO:0006468|GO:0008408|GO:0032392|GO:1902750|GO:0031573|GO:0045003|GO:0017111|GO:0042325|GO:0001932|GO:0006312|GO:0000019|GO:0016605|GO:0001934|GO:1902749|GO:0042327|GO:0031572|GO:0016887|GO:0000014|GO:0046777|GO:0031952|GO:0032508|GO:0031954|GO:0004386|GO:0003678|GO:0042623|GO:0008026|GO:0008094|GO:0004003 locomotion|developmental process|macromolecular complex|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of locomotion|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|immune response|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|viral process|heart development|regulation of cell cycle|cell cycle|reciprocal meiotic recombination|DNA repair|innate immune response|cellular aromatic compound metabolic process|protein C-terminus binding|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|Mre11 complex|hydrolase activity, acting on ester bonds|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|regulation of cytokine production|negative regulation of cell cycle|intracellular membrane-bounded organelle|telomere maintenance|cation binding|negative regulation of viral entry into host cell|cytoplasm|cytokine production|homeostatic process|regulation of viral entry into host cell|negative regulation of biosynthetic process|chromosome organization involved in meiotic cell cycle|positive regulation of cytokine production|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nuclear chromatin|meiotic nuclear division|negative regulation of viral process|regulation of catalytic activity|chromosome segregation|cellular biosynthetic process|protein metabolic process|regulation of viral process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|interaction with host|chromosome organization|regulation of cellular protein metabolic process|cytosol|DNA binding|telomere maintenance via telomerase|sister chromatid segregation|cell cycle checkpoint|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|regulation of type I interferon production|metal ion binding|recombinational repair|telomere maintenance via telomere lengthening|mitotic cell cycle process|macromolecule modification|cardiovascular system development|cell cycle phase transition|synapsis|positive regulation of type I interferon production|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|positive regulation of transferase activity|protein modification process|mitotic cell cycle|meiosis I|site of double-strand break|nuclear lumen|nuclease activity|meiotic chromosome segregation|sister chromatid cohesion|regulation of mitotic cell cycle|regulation of cell cycle process|type I interferon production|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|perinuclear region of cytoplasm|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|viral life cycle|regulation of protein metabolic process|macromolecule biosynthetic process|circulatory system development|nucleus|cellular response to DNA damage stimulus|negative regulation of cell cycle process|double-strand break repair via nonhomologous end joining|double-strand break repair via homologous recombination|negative regulation of DNA replication|positive regulation of protein modification process|telomere organization|DNA replication|chromosome, telomeric region|deoxyribonuclease activity|mitotic cell cycle checkpoint|G2/M transition of mitotic cell cycle|viral entry into host cell|condensed chromosome|mitotic cell cycle phase transition|phosphorylation|mitotic DNA integrity checkpoint|DNA damage checkpoint|nuclear body|negative regulation of DNA endoreduplication|double-stranded DNA binding|regulation of mitotic cell cycle phase transition|condensed nuclear chromosome|exonuclease activity|homologous chromosome segregation|DNA endoreduplication|regulation of DNA recombination|regulation of DNA replication|DNA recombination|endonuclease activity|nuclear chromosome, telomeric region|transition metal ion binding|regulation of DNA endoreduplication|mitotic G2 DNA damage checkpoint|regulation of cell cycle phase transition|nucleic acid phosphodiester bond hydrolysis|entry into host cell|cellular protein modification process|DNA conformation change|pyrophosphatase activity|regulation of kinase activity|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of kinase activity|endodeoxyribonuclease activity|RNA-dependent DNA replication|regulation of G2/M transition of mitotic cell cycle|mitotic G2/M transition checkpoint|negative regulation of G2/M transition of mitotic cell cycle|DNA-dependent DNA replication|manganese ion binding|protein phosphorylation|3'-5' exonuclease activity|DNA geometric change|negative regulation of cell cycle G2/M phase transition|intra-S DNA damage checkpoint|double-strand break repair via synthesis-dependent strand annealing|nucleoside-triphosphatase activity|regulation of phosphorylation|regulation of protein phosphorylation|mitotic recombination|regulation of mitotic recombination|PML body|positive regulation of protein phosphorylation|regulation of cell cycle G2/M phase transition|positive regulation of phosphorylation|G2 DNA damage checkpoint|ATPase activity|single-stranded DNA endodeoxyribonuclease activity|protein autophosphorylation|regulation of protein autophosphorylation|DNA duplex unwinding|positive regulation of protein autophosphorylation|helicase activity|DNA helicase activity|ATPase activity, coupled|ATP-dependent helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity K10865 double-strand break repair protein MRE11[-] - - 11:94415578-94493908 246 310 451 718 782 690 1.73595886039858 1.98813484083315 2.86942676022045 4.53969606291084 4.52771918160147 4.56333561127375 2.19784015381739 4.54358361859535 -1.04774416529107 6.81416960750359e-06 7.16555898071195e-05 DOWN ENSG00000103061 SLC7A6OS solute carrier family 7 member 6 opposite strand [Source:HGNC Symbol;Acc:HGNC:25807] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0043229|GO:0043227|GO:0005622|GO:0002520|GO:0048856|GO:0006810|GO:0007275|GO:0048513|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0048869|GO:0030097|GO:0015031|GO:0030154|GO:0005634|GO:0002244 developmental process|immune system process|cell|cellular process|intracellular organelle|membrane-bounded organelle|intracellular|immune system development|anatomical structure development|transport|multicellular organism development|animal organ development|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|cellular developmental process|hemopoiesis|protein transport|cell differentiation|nucleus|hematopoietic progenitor cell differentiation - - - - 16:68284503-68310951 442 417 362 215 217 214 2.97570120528835 2.55142622933567 2.19730218783922 1.29688801978482 1.19865394299084 1.3502343608634 2.57480987415441 1.28192544121302 1.00615355157249 6.88187989355308e-06 7.23421275852583e-05 UP ENSG00000154556 SORBS2 sorbin and SH3 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24098] GO:0040011|GO:0032502|GO:0040007|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0060090|GO:0005200|GO:0042995|GO:0097159|GO:0030055|GO:0043229|GO:0016049|GO:0043167|GO:0045177|GO:0048870|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031252|GO:0048589|GO:0008307|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0030017|GO:0007507|GO:0030018|GO:0009888|GO:0048468|GO:0016324|GO:0007275|GO:0003676|GO:0048513|GO:0005924|GO:0005912|GO:0035265|GO:0061061|GO:0055017|GO:0043231|GO:0043169|GO:0005737|GO:0003012|GO:0006928|GO:0030027|GO:0030674|GO:0031674|GO:0016477|GO:0048588|GO:0008092|GO:0048869|GO:0030029|GO:0006996|GO:0046872|GO:0003723|GO:0007010|GO:0072358|GO:0042692|GO:0035051|GO:0048738|GO:0061049|GO:0055006|GO:0060537|GO:0043292|GO:0048471|GO:0055001|GO:0030036|GO:0008093|GO:0014896|GO:0030154|GO:0072359|GO:0005856|GO:0005634|GO:0005925|GO:0055002|GO:0015629|GO:0030016|GO:0055013|GO:0051146|GO:0044822|GO:0014706|GO:0055007|GO:0007015|GO:0003300 locomotion|developmental process|growth|structural molecule activity|cell|membrane|cellular process|cell junction|binding|binding, bridging|structural constituent of cytoskeleton|cell projection|organic cyclic compound binding|cell-substrate junction|intracellular organelle|cell growth|ion binding|apical part of cell|cell motility|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|cell leading edge|developmental growth|structural constituent of muscle|intracellular|protein binding|plasma membrane|anatomical structure development|sarcomere|heart development|Z disc|tissue development|cell development|apical plasma membrane|multicellular organism development|nucleic acid binding|animal organ development|cell-substrate adherens junction|adherens junction|organ growth|muscle structure development|cardiac muscle tissue growth|intracellular membrane-bounded organelle|cation binding|cytoplasm|muscle system process|movement of cell or subcellular component|lamellipodium|protein binding, bridging|I band|cell migration|developmental cell growth|cytoskeletal protein binding|cellular developmental process|actin filament-based process|organelle organization|metal ion binding|RNA binding|cytoskeleton organization|cardiovascular system development|muscle cell differentiation|cardiocyte differentiation|cardiac muscle tissue development|cell growth involved in cardiac muscle cell development|cardiac cell development|muscle tissue development|contractile fiber|perinuclear region of cytoplasm|muscle cell development|actin cytoskeleton organization|cytoskeletal adaptor activity|muscle hypertrophy|cell differentiation|circulatory system development|cytoskeleton|nucleus|focal adhesion|striated muscle cell development|actin cytoskeleton|myofibril|cardiac muscle cell development|striated muscle cell differentiation|poly(A) RNA binding|striated muscle tissue development|cardiac muscle cell differentiation|actin filament organization|cardiac muscle hypertrophy - - - - 4:185585444-185956652 0 0 1 5 9 21 0 0 0.00198897556303924 0.00988711672526914 0.0162980611832955 0.0434379133961398 0.000662991854346413 0.0232076971015681 -5.1294684158143 6.96689073434998e-06 7.31842209652654e-05 DOWN ENSG00000232818 RPS2P32 ribosomal protein S2 pseudogene 32 [Source:HGNC Symbol;Acc:HGNC:30518] - - - - - - 7:23490473-23491364 19 12 11 0 2 3 1.50669375166994 0.864851597476271 0.786463226218587 0 0.130121450470596 0.222934121225509 1.0526695251216 0.117685190565368 3.16104789900383 6.97566008985401e-06 7.32505650096734e-05 UP ENSG00000126368 NR1D1 nuclear receptor subfamily 1 group D member 1 [Source:HGNC Symbol;Acc:HGNC:7962] GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0042752|GO:0051716|GO:0042995|GO:0002683|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0000989|GO:0000785|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0004879|GO:0023057|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0019222|GO:0098531|GO:0060341|GO:2000188|GO:0044262|GO:0002757|GO:0042127|GO:0045087|GO:0045595|GO:0003712|GO:0006725|GO:0003707|GO:0006810|GO:1901360|GO:0006082|GO:0061178|GO:0003676|GO:0034641|GO:0015980|GO:0044281|GO:0032940|GO:0006952|GO:0031325|GO:0046483|GO:0032922|GO:0034122|GO:0043231|GO:0043169|GO:0005737|GO:0000981|GO:0002218|GO:0007267|GO:0032880|GO:0005975|GO:0042592|GO:0043005|GO:0009966|GO:0050673|GO:0045184|GO:0009890|GO:0046883|GO:0043197|GO:0019725|GO:0036477|GO:0060086|GO:0048871|GO:0010646|GO:0006139|GO:0009617|GO:0050776|GO:0000790|GO:0008104|GO:0007154|GO:0006629|GO:0007165|GO:0050778|GO:0009968|GO:0042180|GO:0051649|GO:0008134|GO:0009725|GO:0006091|GO:0010817|GO:0048869|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0055114|GO:0000982|GO:0006109|GO:0003677|GO:0005976|GO:0009743|GO:0045940|GO:0010468|GO:0034645|GO:0003714|GO:1904251|GO:0046872|GO:0090276|GO:0020037|GO:0033993|GO:0044309|GO:0002758|GO:0030163|GO:0010869|GO:0010629|GO:0002237|GO:0048878|GO:0051252|GO:0044321|GO:0001659|GO:0051223|GO:0015031|GO:0044265|GO:0046889|GO:0010628|GO:0070201|GO:0071219|GO:0042886|GO:0055082|GO:0051046|GO:0033692|GO:0031981|GO:0030425|GO:0009914|GO:0005977|GO:0009306|GO:0005996|GO:0006508|GO:0005654|GO:0050678|GO:0005694|GO:0002764|GO:0000228|GO:0044342|GO:0001221|GO:0010565|GO:0008202|GO:0035773|GO:0006112|GO:0014070|GO:0034144|GO:0044267|GO:0010467|GO:0008610|GO:0019216|GO:0046903|GO:0071310|GO:0001227|GO:0045598|GO:0046890|GO:0031328|GO:0010871|GO:0009059|GO:0030154|GO:0009755|GO:0008206|GO:0034121|GO:0016070|GO:0032870|GO:0010557|GO:0032496|GO:0005634|GO:0016051|GO:0045089|GO:0048545|GO:0030522|GO:0045088|GO:0043112|GO:0005978|GO:0050796|GO:0043401|GO:0071322|GO:0002790|GO:0019318|GO:0044257|GO:0001222|GO:0000975|GO:0045893|GO:0030073|GO:0045444|GO:0001678|GO:0006699|GO:0010498|GO:0001078|GO:0045892|GO:0000271|GO:0032800|GO:0032774|GO:0043565|GO:0019218|GO:2001141|GO:0034284|GO:0050708|GO:0006111|GO:0015833|GO:1902679|GO:0071383|GO:0002221|GO:0071407|GO:0003690|GO:0006694|GO:0010906|GO:0070857|GO:0051603|GO:0050810|GO:0046914|GO:0019752|GO:0055088|GO:0061469|GO:0071396|GO:0070859|GO:0046879|GO:0035947|GO:0006351|GO:0006355|GO:0033500|GO:0071222|GO:0071333|GO:0042593|GO:0006366|GO:0030072|GO:0019319|GO:1903507|GO:0002224|GO:0006352|GO:0006357|GO:1903506|GO:0006006|GO:0044212|GO:0032787|GO:0000122|GO:0008270|GO:0055092|GO:0006367|GO:0001047|GO:0000976|GO:0001012|GO:0006094|GO:0009749|GO:0001159|GO:0034142|GO:0042632|GO:0001046|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|signal transducer activity|immune system process|synapse|signaling|cell|rhythmic process|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|regulation of circadian rhythm|cellular response to stimulus|cell projection|negative regulation of immune system process|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|transcription factor activity, transcription factor binding|chromatin|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|regulation of metabolic process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|regulation of cellular localization|regulation of cholesterol homeostasis|cellular carbohydrate metabolic process|immune response-activating signal transduction|regulation of cell proliferation|innate immune response|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|steroid hormone receptor activity|transport|organic cyclic compound metabolic process|organic acid metabolic process|regulation of insulin secretion involved in cellular response to glucose stimulus|nucleic acid binding|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|circadian regulation of gene expression|negative regulation of toll-like receptor signaling pathway|intracellular membrane-bounded organelle|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|cell-cell signaling|regulation of protein localization|carbohydrate metabolic process|homeostatic process|neuron projection|regulation of signal transduction|epithelial cell proliferation|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|dendritic spine|cellular homeostasis|somatodendritic compartment|circadian temperature homeostasis|multicellular organismal homeostasis|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|nuclear chromatin|protein localization|cell communication|lipid metabolic process|signal transduction|positive regulation of immune response|negative regulation of signal transduction|cellular ketone metabolic process|establishment of localization in cell|transcription factor binding|response to hormone|generation of precursor metabolites and energy|regulation of hormone levels|cellular developmental process|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|oxidation-reduction process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of carbohydrate metabolic process|DNA binding|polysaccharide metabolic process|response to carbohydrate|positive regulation of steroid metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|regulation of bile acid metabolic process|metal ion binding|regulation of peptide hormone secretion|heme binding|response to lipid|neuron spine|innate immune response-activating signal transduction|protein catabolic process|regulation of receptor biosynthetic process|negative regulation of gene expression|response to molecule of bacterial origin|chemical homeostasis|regulation of RNA metabolic process|response to leptin|temperature homeostasis|regulation of protein transport|protein transport|cellular macromolecule catabolic process|positive regulation of lipid biosynthetic process|positive regulation of gene expression|regulation of establishment of protein localization|cellular response to molecule of bacterial origin|amide transport|cellular chemical homeostasis|regulation of secretion|cellular polysaccharide biosynthetic process|nuclear lumen|dendrite|hormone transport|glycogen metabolic process|protein secretion|monosaccharide metabolic process|proteolysis|nucleoplasm|regulation of epithelial cell proliferation|chromosome|immune response-regulating signaling pathway|nuclear chromosome|type B pancreatic cell proliferation|transcription cofactor binding|regulation of cellular ketone metabolic process|steroid metabolic process|insulin secretion involved in cellular response to glucose stimulus|energy reserve metabolic process|response to organic cyclic compound|negative regulation of toll-like receptor 4 signaling pathway|cellular protein metabolic process|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|secretion|cellular response to organic substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of fat cell differentiation|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|negative regulation of receptor biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|bile acid metabolic process|regulation of toll-like receptor signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|carbohydrate biosynthetic process|positive regulation of innate immune response|response to steroid hormone|intracellular receptor signaling pathway|regulation of innate immune response|receptor metabolic process|glycogen biosynthetic process|regulation of insulin secretion|steroid hormone mediated signaling pathway|cellular response to carbohydrate stimulus|peptide secretion|hexose metabolic process|cellular protein catabolic process|transcription corepressor binding|regulatory region DNA binding|positive regulation of transcription, DNA-templated|insulin secretion|fat cell differentiation|cellular glucose homeostasis|bile acid biosynthetic process|proteasomal protein catabolic process|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|polysaccharide biosynthetic process|receptor biosynthetic process|RNA biosynthetic process|sequence-specific DNA binding|regulation of steroid metabolic process|regulation of RNA biosynthetic process|response to monosaccharide|regulation of protein secretion|regulation of gluconeogenesis|peptide transport|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|pattern recognition receptor signaling pathway|cellular response to organic cyclic compound|double-stranded DNA binding|steroid biosynthetic process|regulation of glucose metabolic process|regulation of bile acid biosynthetic process|proteolysis involved in cellular protein catabolic process|regulation of steroid biosynthetic process|transition metal ion binding|carboxylic acid metabolic process|lipid homeostasis|regulation of type B pancreatic cell proliferation|cellular response to lipid|positive regulation of bile acid biosynthetic process|hormone secretion|regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter|transcription, DNA-templated|regulation of transcription, DNA-templated|carbohydrate homeostasis|cellular response to lipopolysaccharide|cellular response to glucose stimulus|glucose homeostasis|transcription from RNA polymerase II promoter|peptide hormone secretion|hexose biosynthetic process|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|glucose metabolic process|transcription regulatory region DNA binding|monocarboxylic acid metabolic process|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|sterol homeostasis|transcription initiation from RNA polymerase II promoter|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|gluconeogenesis|response to glucose|core promoter proximal region DNA binding|toll-like receptor 4 signaling pathway|cholesterol homeostasis|core promoter sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K03728 nuclear receptor subfamily 1 group D member 1[-] hsa04710 Circadian rhythm - Homo sapiens (human) 17:40092787-40100725 299 265 396 82 80 190 7.62997694994963 6.14580284112961 9.11090949031788 1.87483317428727 1.67499353567261 4.54395490269671 7.62889642713237 2.69792720421886 1.49962295444431 6.99872826718267e-06 7.34669598060729e-05 UP ENSG00000196542 SPTSSB serine palmitoyltransferase small subunit B [Source:HGNC Symbol;Acc:HGNC:24045] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0043231|GO:0016746|GO:0005737|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0006665|GO:0006643|GO:0017059|GO:1990234|GO:0016747|GO:0008610|GO:0002178|GO:0016409|GO:0030148|GO:0004758 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|sphingolipid metabolic process|membrane lipid metabolic process|serine C-palmitoyltransferase complex|transferase complex|transferase activity, transferring acyl groups other than amino-acyl groups|lipid biosynthetic process|palmitoyltransferase complex|palmitoyltransferase activity|sphingolipid biosynthetic process|serine C-palmitoyltransferase activity - - - - 3:161344792-161372880 203 223 212 443 472 521 2.35712557755104 2.35326638021838 2.21940467523548 4.60879645284851 4.49671481691267 5.66960692388642 2.30993221100163 4.92503939788253 -1.09228475160806 7.02448552757601e-06 7.37114203656429e-05 DOWN ENSG00000068650 ATP11A ATPase, class VI, type 11A [Source:HGNC Symbol;Acc:HGNC:13552] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0097035|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0043169|GO:0005774|GO:0005737|GO:0005319|GO:0061024|GO:0005783|GO:0000166|GO:0016021|GO:0010876|GO:0005768|GO:0046872|GO:0035639|GO:0005548|GO:0005769|GO:0001883|GO:0005773|GO:0016818|GO:0006811|GO:0032549|GO:0055037|GO:0006869|GO:0017076|GO:0015914|GO:0045332|GO:0006820|GO:0015711|GO:0000323|GO:0000287|GO:0005524|GO:0030554|GO:0004012|GO:0016462|GO:0005765|GO:0005764|GO:0017111|GO:0016887|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of membrane lipid distribution|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|vacuolar membrane|cytoplasm|lipid transporter activity|membrane organization|endoplasmic reticulum|nucleotide binding|integral component of membrane|lipid localization|endosome|metal ion binding|purine ribonucleoside triphosphate binding|phospholipid transporter activity|early endosome|purine nucleoside binding|vacuole|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|ribonucleoside binding|recycling endosome|lipid transport|purine nucleotide binding|phospholipid transport|phospholipid translocation|anion transport|organic anion transport|lytic vacuole|magnesium ion binding|ATP binding|adenyl nucleotide binding|phospholipid-translocating ATPase activity|pyrophosphatase activity|lysosomal membrane|lysosome|nucleoside-triphosphatase activity|ATPase activity|ATPase activity, coupled|ATPase activity, coupled to movement of substances - - - - 13:112690329-112887168 812 901 1872 2541 2966 3131 1.60146945719807 1.61498216827121 3.32876381290291 4.49019484985917 4.79956493085105 5.78728489308214 2.1817384794574 5.02568155793079 -1.20384108157102 7.04841980772192e-06 7.38846646558041e-05 DOWN ENSG00000198945 L3MBTL3 l(3)mbt-like 3 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:23035] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0002262|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0048513|GO:0034101|GO:0034641|GO:0046483|GO:0043231|GO:0042592|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0030218|GO:0030097|GO:0051252|GO:0006325|GO:0048872|GO:0010467|GO:0009059|GO:0030154|GO:0048469|GO:0016070|GO:0005634|GO:0002521|GO:0032774|GO:2001141|GO:0016568|GO:0048821|GO:0043249|GO:0030099|GO:0006351|GO:0006355|GO:0002573|GO:1903506|GO:0030225|GO:0030851 developmental process|immune system process|cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|myeloid cell homeostasis|biosynthetic process|intracellular|immune system development|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|erythrocyte homeostasis|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|homeostatic process|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|erythrocyte differentiation|hemopoiesis|regulation of RNA metabolic process|chromatin organization|homeostasis of number of cells|gene expression|macromolecule biosynthetic process|cell differentiation|cell maturation|RNA metabolic process|nucleus|leukocyte differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|chromatin modification|erythrocyte development|erythrocyte maturation|myeloid cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|myeloid leukocyte differentiation|regulation of nucleic acid-templated transcription|macrophage differentiation|granulocyte differentiation - - - - 6:130013699-130141451 51 45 40 116 132 140 0.269866648917464 0.216409262284261 0.190832984104937 0.549964275100587 0.573087456930381 0.694285094078199 0.225702965102221 0.605778942036389 -1.42436605672535 7.08066242822751e-06 7.4170810955161e-05 DOWN ENSG00000126016 AMOT angiomotin [Source:HGNC Symbol;Acc:HGNC:17810] GO:0040011|GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0009892|GO:0050794|GO:0040012|GO:0043229|GO:0044089|GO:0009986|GO:0051641|GO:0048870|GO:0023051|GO:0005911|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0031252|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0051272|GO:0006935|GO:0009897|GO:0051130|GO:0001568|GO:0005884|GO:0007275|GO:0010632|GO:0043532|GO:0032535|GO:0031982|GO:0051128|GO:2000147|GO:0022607|GO:0043231|GO:0005737|GO:0032970|GO:0001726|GO:0006928|GO:0009966|GO:0030027|GO:0048598|GO:0032231|GO:0010646|GO:0001525|GO:0008104|GO:0007163|GO:0007154|GO:0044092|GO:0051270|GO:0016477|GO:0007165|GO:0032233|GO:0043114|GO:0010634|GO:0050790|GO:0043086|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0040019|GO:0043296|GO:0008180|GO:0003013|GO:0006996|GO:0051017|GO:0016525|GO:0005829|GO:0090132|GO:0045216|GO:0032956|GO:0001944|GO:0007010|GO:0072358|GO:0031410|GO:0009790|GO:0030334|GO:0001667|GO:0016023|GO:0032432|GO:0007369|GO:0034329|GO:0030010|GO:0045765|GO:0008361|GO:0001570|GO:0051346|GO:0031988|GO:0030036|GO:0034613|GO:0042641|GO:1901342|GO:0035556|GO:0033043|GO:0010594|GO:0030154|GO:0030335|GO:0005923|GO:0051496|GO:1902531|GO:0072359|GO:0008015|GO:0005856|GO:0005634|GO:0051492|GO:0010595|GO:0045995|GO:0043116|GO:0010638|GO:0045793|GO:0015629|GO:0043536|GO:0009792|GO:0030139|GO:0043087|GO:0043535|GO:0003365|GO:0051493|GO:0001725|GO:0035329|GO:0010631|GO:0001702|GO:0031032|GO:0051056|GO:0030038|GO:0007264|GO:0007015|GO:0042074|GO:0051495|GO:0007043|GO:0034260|GO:0043149|GO:0043009|GO:0061572|GO:0043542|GO:0001701|GO:0043534 locomotion|developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|negative regulation of metabolic process|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of cellular component biogenesis|cell surface|cellular localization|cell motility|regulation of signaling|cell-cell junction|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|cell leading edge|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|positive regulation of cellular component movement|chemotaxis|external side of plasma membrane|positive regulation of cellular component organization|blood vessel development|actin filament|multicellular organism development|regulation of epithelial cell migration|angiostatin binding|regulation of cellular component size|vesicle|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|regulation of actin filament-based process|ruffle|movement of cell or subcellular component|regulation of signal transduction|lamellipodium|embryonic morphogenesis|regulation of actin filament bundle assembly|regulation of cell communication|angiogenesis|protein localization|establishment or maintenance of cell polarity|cell communication|negative regulation of molecular function|regulation of cellular component movement|cell migration|signal transduction|positive regulation of actin filament bundle assembly|regulation of vascular permeability|positive regulation of epithelial cell migration|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|positive regulation of embryonic development|apical junction complex|COP9 signalosome|circulatory system process|organelle organization|actin filament bundle assembly|negative regulation of angiogenesis|cytosol|epithelium migration|cell-cell junction organization|regulation of actin cytoskeleton organization|vasculature development|cytoskeleton organization|cardiovascular system development|cytoplasmic vesicle|embryo development|regulation of cell migration|ameboidal-type cell migration|cytoplasmic, membrane-bounded vesicle|actin filament bundle|gastrulation|cell junction assembly|establishment of cell polarity|regulation of angiogenesis|regulation of cell size|vasculogenesis|negative regulation of hydrolase activity|membrane-bounded vesicle|actin cytoskeleton organization|cellular protein localization|actomyosin|regulation of vasculature development|intracellular signal transduction|regulation of organelle organization|regulation of endothelial cell migration|cell differentiation|positive regulation of cell migration|bicellular tight junction|positive regulation of stress fiber assembly|regulation of intracellular signal transduction|circulatory system development|blood circulation|cytoskeleton|nucleus|regulation of stress fiber assembly|positive regulation of endothelial cell migration|regulation of embryonic development|negative regulation of vascular permeability|positive regulation of organelle organization|positive regulation of cell size|actin cytoskeleton|positive regulation of blood vessel endothelial cell migration|embryo development ending in birth or egg hatching|endocytic vesicle|regulation of GTPase activity|regulation of blood vessel endothelial cell migration|establishment of cell polarity involved in ameboidal cell migration|regulation of cytoskeleton organization|stress fiber|hippo signaling|epithelial cell migration|gastrulation with mouth forming second|actomyosin structure organization|regulation of small GTPase mediated signal transduction|contractile actin filament bundle assembly|small GTPase mediated signal transduction|actin filament organization|cell migration involved in gastrulation|positive regulation of cytoskeleton organization|cell-cell junction assembly|negative regulation of GTPase activity|stress fiber assembly|chordate embryonic development|actin filament bundle organization|endothelial cell migration|in utero embryonic development|blood vessel endothelial cell migration K16819 angiomotin[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) X:112774503-112840815 25 27 71 109 151 172 0.164246165610428 0.161213669619462 0.420557404034183 0.641616840382913 0.813947197692631 1.05902837744734 0.248672413088024 0.838197471840961 -1.75304370152198 7.0992916124494e-06 7.43135525238655e-05 DOWN ENSG00000169857 AVEN apoptosis, caspase activation inhibitor [Source:HGNC Symbol;Acc:HGNC:13509] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0005622|GO:0005515|GO:0012505|GO:0010941|GO:0060548|GO:0008219|GO:0043069|GO:0012501|GO:0043067|GO:0042981|GO:0043066|GO:0006915 cell|membrane|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular|protein binding|endomembrane system|regulation of cell death|negative regulation of cell death|cell death|negative regulation of programmed cell death|programmed cell death|regulation of programmed cell death|regulation of apoptotic process|negative regulation of apoptotic process|apoptotic process - - - - 15:33866227-34039176 43 28 17 151 137 80 1.46306342431137 0.865822250223158 0.521497599695652 4.60324968420673 3.8245469069116 2.55098330013038 0.950127758076727 3.6595932970829 -1.94548990356904 7.10553444058875e-06 7.43528304203773e-05 DOWN ENSG00000067082 KLF6 Kruppel-like factor 6 [Source:HGNC Symbol;Acc:HGNC:2235] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0010243|GO:0009611|GO:0001775|GO:0006979|GO:0006139|GO:0046649|GO:0048869|GO:0010035|GO:0044249|GO:0010033|GO:0031323|GO:0003677|GO:0042113|GO:0010468|GO:0034645|GO:0046872|GO:0030097|GO:0030098|GO:0042542|GO:0051252|GO:1901652|GO:0071417|GO:0010628|GO:0042060|GO:0046898|GO:0034599|GO:0014070|GO:0000302|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0010557|GO:0005634|GO:0097305|GO:0002521|GO:0045893|GO:1901653|GO:0030183|GO:0032774|GO:2001141|GO:0071409|GO:0071407|GO:0003690|GO:0034614|GO:0006351|GO:0070301|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506 developmental process|immune system process|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|immune system development|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|response to wounding|cell activation|response to oxidative stress|nucleobase-containing compound metabolic process|lymphocyte activation|cellular developmental process|response to inorganic substance|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|DNA binding|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|hemopoiesis|lymphocyte differentiation|response to hydrogen peroxide|regulation of RNA metabolic process|response to peptide|cellular response to organonitrogen compound|positive regulation of gene expression|wound healing|response to cycloheximide|cellular response to oxidative stress|response to organic cyclic compound|response to reactive oxygen species|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|response to alcohol|leukocyte differentiation|positive regulation of transcription, DNA-templated|cellular response to peptide|B cell differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to cycloheximide|cellular response to organic cyclic compound|double-stranded DNA binding|cellular response to reactive oxygen species|transcription, DNA-templated|cellular response to hydrogen peroxide|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 10:3775996-3785281 776 740 1457 477 576 512 4.05734562974226 3.51634743054381 6.86837057020476 2.23458295965507 2.47098861660519 2.50887224764696 4.81402121016361 2.40481460796907 1.00131682021853 7.11402420314199e-06 7.43895196359373e-05 UP ENSG00000186162 CIDECP cell death-inducing DFFA-like effector c pseudogene [Source:HGNC Symbol;Acc:HGNC:24230] - - - - - - 3:10014238-10026365 294 288 177 115 111 104 3.68473802639865 3.28042930523955 2.00007350032361 1.29138441460734 1.14142956008404 1.22157401139042 2.98841361065394 1.21812932869393 1.29471252560667 7.11352613418512e-06 7.43895196359373e-05 UP ENSG00000262772 RP11-353N14.2 - - - - - - - 17:79823452-79827704 6 4 4 28 26 20 0.237360949490487 0.14381946773841 0.142680205809202 0.992505455693136 0.843962294381934 0.741530168375372 0.174620207679366 0.859332639483481 -2.29899617049816 7.22162368186679e-06 7.54882189770487e-05 DOWN ENSG00000269947 RP11-849F2.9 - - - - - - - 17:8277763-8278436 16 16 13 4 2 2 1.67923333548893 1.5261080612242 1.23009095219645 0.376147493215636 0.172208210415091 0.196693606462071 1.47847744963653 0.248349770030933 2.57366692306183 7.25778820367548e-06 7.5820870843056e-05 UP ENSG00000254876 RP11-23J9.5 - - - - - - - 9:97238449-97297314 7 12 5 44 46 25 0.126868580863849 0.197655040980998 0.081695333283807 0.714499973479037 0.684024094773648 0.424636224620589 0.135406318376218 0.607720097624425 -2.16611194334246 7.35823224184046e-06 7.67281401843888e-05 DOWN ENSG00000127580 WDR24 WD repeat domain 24 [Source:HGNC Symbol;Acc:HGNC:20852] GO:0032991|GO:0023052|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0023051|GO:0009605|GO:0005515|GO:0043234|GO:0009991|GO:0033554|GO:0031668|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0061700|GO:0009967|GO:0042594|GO:1902533|GO:0009267|GO:0035556|GO:0031669|GO:1902531|GO:0031667|GO:0032006|GO:0031929|GO:0032008|GO:0034198 macromolecular complex|signaling|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|regulation of signaling|response to external stimulus|protein binding|protein complex|response to extracellular stimulus|cellular response to stress|cellular response to extracellular stimulus|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|GATOR2 complex|positive regulation of signal transduction|response to starvation|positive regulation of intracellular signal transduction|cellular response to starvation|intracellular signal transduction|cellular response to nutrient levels|regulation of intracellular signal transduction|response to nutrient levels|regulation of TOR signaling|TOR signaling|positive regulation of TOR signaling|cellular response to amino acid starvation - - - - 16:684622-690444 183 234 253 474 547 448 2.62201164645103 3.04703842141022 3.26826276906405 6.08497027430564 6.43039676935235 6.01574869697975 2.9791042789751 6.17703858021258 -1.05203671762793 7.42084522151623e-06 7.73540199871318e-05 DOWN ENSG00000172336 POP7 POP7 homolog, ribonuclease P/MRP subunit [Source:HGNC Symbol;Acc:HGNC:19949] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0005737|GO:0030529|GO:0006139|GO:0005730|GO:0003723|GO:0030677|GO:0031981|GO:0004518|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0090501|GO:0006396|GO:0034660|GO:0005655|GO:0004519|GO:0004540|GO:0044822|GO:0090305|GO:0006399|GO:0090502|GO:0004521|GO:0008033|GO:0004526|GO:0016891 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|nucleolus|RNA binding|ribonuclease P complex|nuclear lumen|nuclease activity|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA phosphodiester bond hydrolysis|RNA processing|ncRNA metabolic process|nucleolar ribonuclease P complex|endonuclease activity|ribonuclease activity|poly(A) RNA binding|nucleic acid phosphodiester bond hydrolysis|tRNA metabolic process|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|tRNA processing|ribonuclease P activity|endoribonuclease activity, producing 5'-phosphomonoesters K14527 ribonuclease P/MRP protein subunit RPP20[3.1.26.5] hsa03013|hsa03008 RNA transport - Homo sapiens (human)|Ribosome biogenesis in eukaryotes - Homo sapiens (human) 7:100706053-100707495 1882 1617 1238 870 948 602 94.4161189621944 73.7253330391097 55.9965667893372 39.1060158438276 39.0213958285478 28.3042733380602 74.7126729302138 35.4772283368119 1.07445967362239 7.45181395559502e-06 7.76226286916726e-05 UP ENSG00000205822 TPTE2P6 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6 [Source:HGNC Symbol;Acc:HGNC:42644] - - - - - - 13:24408157-24597676 0 0 3 7 15 19 0 0 0.0873120866331682 0.202480104583213 0.39735266347407 0.57488370409742 0.0291040288777227 0.391572157384901 -3.74998740151897 7.51512939452546e-06 7.82548562763038e-05 DOWN ENSG00000154240 CEP112 centrosomal protein 112kDa [Source:HGNC Symbol;Acc:HGNC:28514] GO:0045202|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0060077|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0005737|GO:0008104|GO:0005813|GO:0005815|GO:0035418|GO:0005856|GO:0097120|GO:0015630 synapse|cell|membrane|binding|intracellular organelle|inhibitory synapse|cell periphery|intracellular|protein binding|plasma membrane|cytoplasm|protein localization|centrosome|microtubule organizing center|protein localization to synapse|cytoskeleton|receptor localization to synapse|microtubule cytoskeleton - - - - 17:65635538-66192084 16 11 32 65 62 92 0.106472555796758 0.0665278219687332 0.191987856589002 0.387544226144322 0.338509015410033 0.573759572813216 0.121662744784831 0.433270938122524 -1.83238201256254 7.58508069510336e-06 7.89281976547981e-05 DOWN ENSG00000205918 PDPK2P 3-phosphoinositide dependent protein kinase 2, pseudogene [Source:HGNC Symbol;Acc:HGNC:49897] - - - - - - 16:2616121-2643296 81 115 75 221 231 299 1.08579055771677 1.40099870451978 0.906434295475252 2.65428985020279 2.54060895150504 3.75628310672764 1.13107451923727 2.98372730281182 -1.39942170440845 7.61199374694071e-06 7.91530690773835e-05 DOWN ENSG00000126249 PDCD2L programmed cell death 2-like [Source:HGNC Symbol;Acc:HGNC:28194] GO:0005623|GO:0016020|GO:0009987|GO:0005622|GO:0007049|GO:0005737 cell|membrane|cellular process|intracellular|cell cycle|cytoplasm - - - - 19:34404384-34426168 768 782 514 328 428 223 19.0818033931327 17.6581422814008 11.5142434133165 7.30179640137312 8.72508217651921 5.19267813654429 16.08472969595 7.07318557147887 1.18525967435577 7.64037287427226e-06 7.93928617433081e-05 UP ENSG00000135540 NHSL1 NHS like 1 [Source:HGNC Symbol;Acc:HGNC:21021] - - - - - - 6:138422043-138692571 67 70 88 214 232 149 0.379758063369247 0.36058582896914 0.449706336458599 1.0867831434598 1.07891479684907 0.791494019454105 0.396683409598995 0.985730653254325 -1.31320542887852 7.6465628932491e-06 7.94295367484547e-05 DOWN ENSG00000226383 AC093375.1 - - - - - - - 2:156011617-156024613 2 5 11 22 29 70 0.0627627000427374 0.142620645542687 0.311235668938323 0.618595669537852 0.746707197165079 2.0588138023263 0.172206338174582 1.14137222300974 -2.72855921020166 7.67872463232048e-06 7.97358765820159e-05 DOWN ENSG00000091651 ORC6 origin recognition complex subunit 6 [Source:HGNC Symbol;Acc:HGNC:17151] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0006725|GO:0000808|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0016234|GO:0006139|GO:0044249|GO:0003677|GO:0034645|GO:1903047|GO:0005664|GO:0044770|GO:0016235|GO:0000278|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0009059|GO:0005856|GO:0005634|GO:0015629|GO:0006260|GO:0044772|GO:0000082 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|cell cycle|cellular aromatic compound metabolic process|origin recognition complex|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|inclusion body|nucleobase-containing compound metabolic process|cellular biosynthetic process|DNA binding|cellular macromolecule biosynthetic process|mitotic cell cycle process|nuclear origin of replication recognition complex|cell cycle phase transition|aggresome|mitotic cell cycle|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|macromolecule biosynthetic process|cytoskeleton|nucleus|actin cytoskeleton|DNA replication|mitotic cell cycle phase transition|G1/S transition of mitotic cell cycle K02608 origin recognition complex subunit 6[-] hsa04110 Cell cycle - Homo sapiens (human) 16:46689643-46698394 1550 1661 1254 842 950 541 13.4151626896759 13.0651365320719 9.78534295912307 6.52941179310138 6.74614418843414 4.38824193336244 12.0885473936236 5.88793263829932 1.03780782396227 7.69336634188098e-06 7.98601386545601e-05 UP ENSG00000177409 SAMD9L sterile alpha motif domain containing 9-like [Source:HGNC Symbol;Acc:HGNC:1349] GO:0005488|GO:0005515 binding|protein binding - - - - 7:93130055-93148369 33 45 57 107 120 181 0.116511453392203 0.144395259207187 0.181444913465538 0.33848399377036 0.34761991514738 0.598911942357146 0.147450542021643 0.428338617091629 -1.53852062432469 7.75491278754429e-06 8.04430737871255e-05 DOWN ENSG00000110841 PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) [Source:HGNC Symbol;Acc:HGNC:9249] GO:0005623|GO:0016020|GO:0030054|GO:0005488|GO:0030055|GO:0007155|GO:0071944|GO:0005515|GO:0005886|GO:0005924|GO:0005912|GO:0005925 cell|membrane|cell junction|binding|cell-substrate junction|cell adhesion|cell periphery|protein binding|plasma membrane|cell-substrate adherens junction|adherens junction|focal adhesion - - - - 12:27523431-27695564 242 259 416 652 683 676 0.957721683162287 0.931545354321185 1.48433490808411 2.31190026289534 2.21775186100069 2.50726223650943 1.12453398185586 2.34563812013515 -1.0606531967158 7.85613589451716e-06 8.14082197136117e-05 DOWN ENSG00000184381 PLA2G6 phospholipase A2 group VI [Source:HGNC Symbol;Acc:HGNC:9039] GO:0040011|GO:0000003|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0044708|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0016787|GO:0009058|GO:0031224|GO:0005615|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0048609|GO:0019222|GO:0060341|GO:0002757|GO:0044255|GO:0050804|GO:0006935|GO:0045087|GO:0006959|GO:0046887|GO:0006810|GO:0051130|GO:0010941|GO:0061178|GO:0060627|GO:0050877|GO:0034641|GO:0016788|GO:0044281|GO:0032940|GO:0006952|GO:0043270|GO:0019637|GO:0031325|GO:0051128|GO:0033554|GO:0010942|GO:0098542|GO:0043231|GO:0019899|GO:0043008|GO:0005737|GO:0003012|GO:0007267|GO:0032880|GO:0051222|GO:0042592|GO:0009966|GO:1903524|GO:0045184|GO:0046883|GO:0019725|GO:0060135|GO:0010646|GO:0009617|GO:0050776|GO:0008104|GO:0005516|GO:0007154|GO:0055085|GO:0007565|GO:0006629|GO:0007165|GO:0050778|GO:0035774|GO:0051649|GO:0019730|GO:0008219|GO:0007611|GO:0051047|GO:0050805|GO:0010817|GO:0016021|GO:0009967|GO:0044249|GO:0010876|GO:0019538|GO:0010033|GO:0031323|GO:0003013|GO:0032370|GO:0006996|GO:0016192|GO:1902533|GO:2001235|GO:0032268|GO:0006909|GO:0005829|GO:0009743|GO:0035150|GO:0006936|GO:0008654|GO:0006665|GO:0046486|GO:0007166|GO:0090276|GO:0002793|GO:0043412|GO:2000193|GO:0016042|GO:0007005|GO:0048878|GO:0006066|GO:0009308|GO:0005815|GO:0051223|GO:0015031|GO:0046889|GO:0045921|GO:0006643|GO:2000303|GO:0006887|GO:0036211|GO:0007613|GO:0070201|GO:0042886|GO:0006811|GO:0046470|GO:0055082|GO:0050714|GO:0002429|GO:0017157|GO:0051046|GO:0051967|GO:0032368|GO:0051966|GO:0006869|GO:0009914|GO:0009306|GO:0051247|GO:0034765|GO:0005739|GO:0002764|GO:0043269|GO:0035773|GO:0019900|GO:0032270|GO:0012501|GO:0016298|GO:0006796|GO:0043603|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0008610|GO:0019216|GO:0046903|GO:0071310|GO:0050890|GO:0046890|GO:0031328|GO:0032305|GO:0051246|GO:0042742|GO:0009059|GO:0043068|GO:1902531|GO:0008015|GO:0034976|GO:0005856|GO:0045909|GO:0052689|GO:0043067|GO:0038096|GO:0006644|GO:0022898|GO:0097190|GO:0019731|GO:0034220|GO:0090277|GO:0010638|GO:0050796|GO:0071322|GO:0002790|GO:0004620|GO:0090036|GO:0036152|GO:0006672|GO:0030073|GO:0098655|GO:0006820|GO:0015711|GO:0031401|GO:0001678|GO:0090037|GO:0006939|GO:0042312|GO:0043065|GO:0090238|GO:2000304|GO:0046474|GO:0004623|GO:0006812|GO:0008637|GO:0034284|GO:0050708|GO:0016310|GO:0015833|GO:0002768|GO:0015908|GO:0010822|GO:0046942|GO:0032412|GO:0090200|GO:0015630|GO:0010821|GO:0032024|GO:0070528|GO:0006576|GO:0001836|GO:0042981|GO:0044070|GO:0050801|GO:2000191|GO:0036151|GO:0002431|GO:0006897|GO:0019901|GO:0030148|GO:0006464|GO:0046717|GO:0046879|GO:0006650|GO:0006915|GO:0006873|GO:0033500|GO:0050880|GO:0046513|GO:0071333|GO:0042593|GO:0015718|GO:1903169|GO:0030072|GO:0090237|GO:0006655|GO:0006468|GO:0042311|GO:0042325|GO:0001932|GO:0047499|GO:0038093|GO:1901019|GO:0030001|GO:0001934|GO:0051924|GO:2001257|GO:0030003|GO:0042327|GO:0007268|GO:0015909|GO:0014832|GO:0032049|GO:0038094|GO:0070588|GO:0007270|GO:0055065|GO:0050482|GO:0006875|GO:0009749|GO:1901339|GO:0032048|GO:0006874|GO:0006816|GO:0035965|GO:0035249|GO:0055074|GO:0051480|GO:0007204 locomotion|reproduction|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|single-organism behavior|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|biosynthetic process|intrinsic component of membrane|extracellular space|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|multicellular organismal reproductive process|regulation of metabolic process|regulation of cellular localization|immune response-activating signal transduction|cellular lipid metabolic process|modulation of synaptic transmission|chemotaxis|innate immune response|humoral immune response|positive regulation of hormone secretion|transport|positive regulation of cellular component organization|regulation of cell death|regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of vesicle-mediated transport|neurological system process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|secretion by cell|defense response|positive regulation of ion transport|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of cell death|defense response to other organism|intracellular membrane-bounded organelle|enzyme binding|ATP-dependent protein binding|cytoplasm|muscle system process|cell-cell signaling|regulation of protein localization|positive regulation of protein transport|homeostatic process|regulation of signal transduction|positive regulation of blood circulation|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|maternal process involved in female pregnancy|regulation of cell communication|response to bacterium|regulation of immune response|protein localization|calmodulin binding|cell communication|transmembrane transport|female pregnancy|lipid metabolic process|signal transduction|positive regulation of immune response|positive regulation of insulin secretion involved in cellular response to glucose stimulus|establishment of localization in cell|antimicrobial humoral response|cell death|learning or memory|positive regulation of secretion|negative regulation of synaptic transmission|regulation of hormone levels|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|protein metabolic process|response to organic substance|regulation of cellular metabolic process|circulatory system process|positive regulation of lipid transport|organelle organization|vesicle-mediated transport|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|phagocytosis|cytosol|response to carbohydrate|regulation of tube size|muscle contraction|phospholipid biosynthetic process|sphingolipid metabolic process|glycerolipid metabolic process|cell surface receptor signaling pathway|regulation of peptide hormone secretion|positive regulation of peptide secretion|macromolecule modification|positive regulation of fatty acid transport|lipid catabolic process|mitochondrion organization|chemical homeostasis|alcohol metabolic process|amine metabolic process|microtubule organizing center|regulation of protein transport|protein transport|positive regulation of lipid biosynthetic process|positive regulation of exocytosis|membrane lipid metabolic process|regulation of ceramide biosynthetic process|exocytosis|protein modification process|memory|regulation of establishment of protein localization|amide transport|ion transport|phosphatidylcholine metabolic process|cellular chemical homeostasis|positive regulation of protein secretion|immune response-activating cell surface receptor signaling pathway|regulation of exocytosis|regulation of secretion|negative regulation of synaptic transmission, glutamatergic|regulation of lipid transport|regulation of synaptic transmission, glutamatergic|lipid transport|hormone transport|protein secretion|positive regulation of protein metabolic process|regulation of ion transmembrane transport|mitochondrion|immune response-regulating signaling pathway|regulation of ion transport|insulin secretion involved in cellular response to glucose stimulus|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|lipase activity|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|lipid biosynthetic process|regulation of lipid metabolic process|secretion|cellular response to organic substance|cognition|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|positive regulation of icosanoid secretion|regulation of protein metabolic process|defense response to bacterium|macromolecule biosynthetic process|positive regulation of programmed cell death|regulation of intracellular signal transduction|blood circulation|response to endoplasmic reticulum stress|cytoskeleton|positive regulation of vasodilation|carboxylic ester hydrolase activity|regulation of programmed cell death|Fc-gamma receptor signaling pathway involved in phagocytosis|phospholipid metabolic process|regulation of transmembrane transporter activity|apoptotic signaling pathway|antibacterial humoral response|ion transmembrane transport|positive regulation of peptide hormone secretion|positive regulation of organelle organization|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|phospholipase activity|regulation of protein kinase C signaling|phosphatidylethanolamine acyl-chain remodeling|ceramide metabolic process|insulin secretion|cation transmembrane transport|anion transport|organic anion transport|positive regulation of protein modification process|cellular glucose homeostasis|positive regulation of protein kinase C signaling|smooth muscle contraction|regulation of vasodilation|positive regulation of apoptotic process|positive regulation of arachidonic acid secretion|positive regulation of ceramide biosynthetic process|glycerophospholipid biosynthetic process|phospholipase A2 activity|cation transport|apoptotic mitochondrial changes|response to monosaccharide|regulation of protein secretion|phosphorylation|peptide transport|immune response-regulating cell surface receptor signaling pathway|fatty acid transport|positive regulation of mitochondrion organization|carboxylic acid transport|regulation of ion transmembrane transporter activity|positive regulation of release of cytochrome c from mitochondria|microtubule cytoskeleton|regulation of mitochondrion organization|positive regulation of insulin secretion|protein kinase C signaling|cellular biogenic amine metabolic process|release of cytochrome c from mitochondria|regulation of apoptotic process|regulation of anion transport|ion homeostasis|regulation of fatty acid transport|phosphatidylcholine acyl-chain remodeling|Fc receptor mediated stimulatory signaling pathway|endocytosis|protein kinase binding|sphingolipid biosynthetic process|cellular protein modification process|acid secretion|hormone secretion|glycerophospholipid metabolic process|apoptotic process|cellular ion homeostasis|carbohydrate homeostasis|regulation of blood vessel size|ceramide biosynthetic process|cellular response to glucose stimulus|glucose homeostasis|monocarboxylic acid transport|regulation of calcium ion transmembrane transport|peptide hormone secretion|regulation of arachidonic acid secretion|phosphatidylglycerol biosynthetic process|protein phosphorylation|vasodilation|regulation of phosphorylation|regulation of protein phosphorylation|calcium-independent phospholipase A2 activity|Fc receptor signaling pathway|regulation of calcium ion transmembrane transporter activity|metal ion transport|positive regulation of protein phosphorylation|regulation of calcium ion transport|regulation of cation channel activity|cellular cation homeostasis|positive regulation of phosphorylation|synaptic transmission|long-chain fatty acid transport|urinary bladder smooth muscle contraction|cardiolipin biosynthetic process|Fc-gamma receptor signaling pathway|calcium ion transmembrane transport|neuron-neuron synaptic transmission|metal ion homeostasis|arachidonic acid secretion|cellular metal ion homeostasis|response to glucose|regulation of store-operated calcium channel activity|cardiolipin metabolic process|cellular calcium ion homeostasis|calcium ion transport|cardiolipin acyl-chain remodeling|synaptic transmission, glutamatergic|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K16343 calcium-independent phospholipase A2[3.1.1.4] hsa01100|hsa04014|hsa04270|hsa04750|hsa00564|hsa04666|hsa00590|hsa00565|hsa00591|hsa00592 Metabolic pathways - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human)|Ether lipid metabolism - Homo sapiens (human)|Linoleic acid metabolism - Homo sapiens (human)|alpha-Linolenic acid metabolism - Homo sapiens (human) 22:38111495-38205690 75 78 180 277 325 349 0.407250259801453 0.384924354200309 0.881229935210983 1.34765387649334 1.44794749182958 1.77605099590006 0.557801516404248 1.52388412140766 -1.4499294406531 7.87650501113464e-06 8.15909717565626e-05 DOWN ENSG00000168038 ULK4 unc-51 like kinase 4 [Source:HGNC Symbol;Acc:HGNC:15784] GO:0040011|GO:0032502|GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0040012|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0016043|GO:0050793|GO:0016740|GO:0048856|GO:0019222|GO:0045595|GO:0048468|GO:0007275|GO:0043168|GO:0001882|GO:0016772|GO:0051128|GO:0033554|GO:0006928|GO:0009966|GO:0010646|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0000166|GO:0030030|GO:0048869|GO:2000145|GO:0007017|GO:0019538|GO:0023014|GO:0031323|GO:0006996|GO:0000165|GO:0032268|GO:0031175|GO:0031344|GO:0035639|GO:0043412|GO:0007010|GO:0001883|GO:0030334|GO:0036211|GO:0001764|GO:0032549|GO:0031098|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0007399|GO:0017076|GO:0051246|GO:0030154|GO:1902531|GO:0000226|GO:0016773|GO:0051960|GO:0048666|GO:0030182|GO:0090036|GO:2001222|GO:0010975|GO:0043408|GO:0005524|GO:0030554|GO:0016310|GO:0070528|GO:0032872|GO:0004672|GO:0022008|GO:0006464|GO:0050767|GO:0051403|GO:1900744|GO:0046328|GO:0038066|GO:0006468|GO:0048699|GO:0042325|GO:0007254|GO:0001932|GO:0004674|GO:0045664 locomotion|developmental process|signaling|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|regulation of locomotion|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|cellular component organization|regulation of developmental process|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cell development|multicellular organism development|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|cellular response to stress|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|cell communication|regulation of cellular component movement|cell migration|signal transduction|nucleotide binding|cell projection organization|cellular developmental process|regulation of cell motility|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|organelle organization|MAPK cascade|regulation of cellular protein metabolic process|neuron projection development|regulation of cell projection organization|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|purine nucleoside binding|regulation of cell migration|protein modification process|neuron migration|ribonucleoside binding|stress-activated protein kinase signaling cascade|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|regulation of intracellular signal transduction|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|regulation of nervous system development|neuron development|neuron differentiation|regulation of protein kinase C signaling|regulation of neuron migration|regulation of neuron projection development|regulation of MAPK cascade|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase C signaling|regulation of stress-activated MAPK cascade|protein kinase activity|neurogenesis|cellular protein modification process|regulation of neurogenesis|stress-activated MAPK cascade|regulation of p38MAPK cascade|regulation of JNK cascade|p38MAPK cascade|protein phosphorylation|generation of neurons|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity|regulation of neuron differentiation - - - - 3:41246599-41962430 12 9 17 64 58 32 0.0989934712917642 0.0674771012675796 0.126436560905803 0.473031642030709 0.392561418795232 0.247396608640068 0.0976357111550489 0.37099655648867 -1.92592496777619 7.88285697973764e-06 8.16284468515739e-05 DOWN ENSG00000277957 SENP3-EIF4A1 SENP3-EIF4A1 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:49182] GO:0008152|GO:0003824|GO:0071704|GO:0016787|GO:0008233|GO:0019538|GO:0006508|GO:0008234 metabolic process|catalytic activity|organic substance metabolic process|hydrolase activity|peptidase activity|protein metabolic process|proteolysis|cysteine-type peptidase activity - - - - 17:7563287-7578715 0 10293 0 0 0 0 0 188.039239163098 0 0 0 0 62.6797463876993 0 Inf 7.91842140759975e-06 8.19682915057154e-05 UP ENSG00000010810 FYN FYN proto-oncogene, Src family tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:4037] GO:0040011|GO:0032502|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0007631|GO:0097159|GO:0009892|GO:0048523|GO:0051606|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0060076|GO:0043229|GO:0006950|GO:0071704|GO:0050900|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:0016032|GO:0060341|GO:0002757|GO:0042127|GO:0002250|GO:0036119|GO:0050817|GO:0016337|GO:0009898|GO:0008360|GO:0006935|GO:0045087|GO:0045595|GO:0070661|GO:0048468|GO:0050867|GO:0044325|GO:0006810|GO:0051130|GO:0009612|GO:0005884|GO:0010941|GO:0007275|GO:0050688|GO:0048513|GO:0050877|GO:0070489|GO:0005102|GO:0016358|GO:0043168|GO:0006952|GO:0030155|GO:0030900|GO:0001882|GO:0016772|GO:0031325|GO:0051128|GO:0007420|GO:0098542|GO:0098609|GO:0009582|GO:0045597|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0002218|GO:0009611|GO:0060322|GO:0032880|GO:0071559|GO:0006928|GO:0032403|GO:0031234|GO:0009615|GO:0002696|GO:0001775|GO:0098562|GO:0009966|GO:0019897|GO:0014069|GO:0060548|GO:0042493|GO:0010646|GO:0043085|GO:0050776|GO:1900182|GO:0008104|GO:0046649|GO:0050906|GO:0050865|GO:0007154|GO:0016477|GO:0007165|GO:0050778|GO:0009968|GO:0045785|GO:0008092|GO:0009725|GO:0008219|GO:0007611|GO:0051607|GO:0050790|GO:0031295|GO:0000166|GO:0030030|GO:0043548|GO:0001948|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0050878|GO:0005768|GO:0071774|GO:0000165|GO:0016192|GO:1902533|GO:0051249|GO:0015631|GO:0032268|GO:0000902|GO:0006909|GO:0005829|GO:0031175|GO:0031344|GO:0010468|GO:0030168|GO:1901215|GO:0032943|GO:0046872|GO:0007166|GO:0070851|GO:0035639|GO:0036120|GO:0043412|GO:0002758|GO:0030163|GO:0007417|GO:0007612|GO:0010629|GO:0010720|GO:0051427|GO:0043069|GO:2001234|GO:0048813|GO:0007596|GO:0001883|GO:0034109|GO:0070997|GO:1901652|GO:0031346|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0032269|GO:0071560|GO:0042060|GO:0001764|GO:0006811|GO:0032549|GO:0051251|GO:0002429|GO:0007600|GO:0022407|GO:0050769|GO:0043434|GO:0007599|GO:0044344|GO:0042609|GO:0007159|GO:0051247|GO:0070848|GO:0001664|GO:0022604|GO:0046875|GO:0005739|GO:0002764|GO:0016301|GO:1901214|GO:0034613|GO:0032270|GO:0050982|GO:0042110|GO:0012501|GO:0006796|GO:0042608|GO:0035556|GO:0050974|GO:0044267|GO:0051174|GO:0042176|GO:0042610|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0050890|GO:0097485|GO:0017076|GO:0051246|GO:0046651|GO:0030154|GO:0022409|GO:0048858|GO:0045121|GO:1903827|GO:1902531|GO:0042177|GO:0016773|GO:0032870|GO:0005856|GO:0005634|GO:0043067|GO:0038096|GO:0050690|GO:0045089|GO:0097305|GO:0051960|GO:0097190|GO:0045088|GO:0048666|GO:0030182|GO:2001237|GO:0015629|GO:0007411|GO:0042098|GO:0010975|GO:0033365|GO:0031401|GO:0050863|GO:0043122|GO:0008543|GO:0019233|GO:0050954|GO:1901653|GO:0043408|GO:0043523|GO:0014068|GO:0050966|GO:2001240|GO:0005524|GO:0006812|GO:0097192|GO:2001236|GO:0071363|GO:0030554|GO:0016310|GO:0002768|GO:0038179|GO:0034112|GO:0070486|GO:0061564|GO:0048017|GO:0045471|GO:0007167|GO:0043123|GO:0007249|GO:0071375|GO:0043410|GO:0042981|GO:0043066|GO:0004672|GO:0032868|GO:0051402|GO:0002431|GO:0014066|GO:0043524|GO:0006897|GO:1900180|GO:0051428|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050870|GO:0050851|GO:0050767|GO:0048812|GO:0097191|GO:0010976|GO:0043549|GO:0006915|GO:1903039|GO:0033674|GO:0045666|GO:0048011|GO:0000186|GO:0007259|GO:0007265|GO:0002223|GO:0045859|GO:0048015|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0046425|GO:0043405|GO:2001239|GO:0042325|GO:0004713|GO:0001932|GO:0032869|GO:0018193|GO:0038093|GO:0046427|GO:0030001|GO:0001934|GO:0050798|GO:0050852|GO:0071593|GO:0045664|GO:0042327|GO:0034504|GO:0007169|GO:0004715|GO:0032446|GO:0048010|GO:0050731|GO:0038094|GO:0050730|GO:0048013|GO:0046777|GO:0038095|GO:0031396|GO:0007260|GO:0031397|GO:0014065|GO:0042531|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0018108|GO:0038083|GO:0007173|GO:0042506|GO:0042523|GO:0006816|GO:0016567 locomotion|developmental process|immune system process|synapse|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|feeding behavior|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|detection of stimulus|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|excitatory synapse|intracellular organelle|response to stress|organic substance metabolic process|leukocyte migration|catabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|viral process|regulation of cellular localization|immune response-activating signal transduction|regulation of cell proliferation|adaptive immune response|response to platelet-derived growth factor|coagulation|single organismal cell-cell adhesion|cytoplasmic side of plasma membrane|regulation of cell shape|chemotaxis|innate immune response|regulation of cell differentiation|leukocyte proliferation|cell development|positive regulation of cell activation|ion channel binding|transport|positive regulation of cellular component organization|response to mechanical stimulus|actin filament|regulation of cell death|multicellular organism development|regulation of defense response to virus|animal organ development|neurological system process|T cell aggregation|receptor binding|dendrite development|anion binding|defense response|regulation of cell adhesion|forebrain development|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|regulation of cellular component organization|brain development|defense response to other organism|cell-cell adhesion|detection of abiotic stimulus|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|activation of innate immune response|response to wounding|head development|regulation of protein localization|response to transforming growth factor beta|movement of cell or subcellular component|protein complex binding|extrinsic component of cytoplasmic side of plasma membrane|response to virus|positive regulation of leukocyte activation|cell activation|cytoplasmic side of membrane|regulation of signal transduction|extrinsic component of plasma membrane|postsynaptic density|negative regulation of cell death|response to drug|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|positive regulation of protein localization to nucleus|protein localization|lymphocyte activation|detection of stimulus involved in sensory perception|regulation of cell activation|cell communication|cell migration|signal transduction|positive regulation of immune response|negative regulation of signal transduction|positive regulation of cell adhesion|cytoskeletal protein binding|response to hormone|cell death|learning or memory|defense response to virus|regulation of catalytic activity|T cell costimulation|nucleotide binding|cell projection organization|phosphatidylinositol 3-kinase binding|glycoprotein binding|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|endosome|response to fibroblast growth factor|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|tubulin binding|regulation of cellular protein metabolic process|cell morphogenesis|phagocytosis|cytosol|neuron projection development|regulation of cell projection organization|regulation of gene expression|platelet activation|negative regulation of neuron death|mononuclear cell proliferation|metal ion binding|cell surface receptor signaling pathway|growth factor receptor binding|purine ribonucleoside triphosphate binding|cellular response to platelet-derived growth factor stimulus|macromolecule modification|innate immune response-activating signal transduction|protein catabolic process|central nervous system development|learning|negative regulation of gene expression|positive regulation of cell development|hormone receptor binding|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|dendrite morphogenesis|blood coagulation|purine nucleoside binding|homotypic cell-cell adhesion|neuron death|response to peptide|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|wound healing|neuron migration|ion transport|ribonucleoside binding|positive regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|sensory perception|regulation of cell-cell adhesion|positive regulation of neurogenesis|response to peptide hormone|hemostasis|cellular response to fibroblast growth factor stimulus|CD4 receptor binding|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|response to growth factor|G-protein coupled receptor binding|regulation of cell morphogenesis|ephrin receptor binding|mitochondrion|immune response-regulating signaling pathway|kinase activity|regulation of neuron death|cellular protein localization|positive regulation of cellular protein metabolic process|detection of mechanical stimulus|T cell activation|programmed cell death|phosphate-containing compound metabolic process|T cell receptor binding|intracellular signal transduction|detection of mechanical stimulus involved in sensory perception|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|CD8 receptor binding|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|cognition|neuron projection guidance|purine nucleotide binding|regulation of protein metabolic process|lymphocyte proliferation|cell differentiation|positive regulation of cell-cell adhesion|cell projection morphogenesis|membrane raft|regulation of cellular protein localization|regulation of intracellular signal transduction|negative regulation of protein catabolic process|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|cytoskeleton|nucleus|regulation of programmed cell death|Fc-gamma receptor signaling pathway involved in phagocytosis|regulation of defense response to virus by virus|positive regulation of innate immune response|response to alcohol|regulation of nervous system development|apoptotic signaling pathway|regulation of innate immune response|neuron development|neuron differentiation|negative regulation of extrinsic apoptotic signaling pathway|actin cytoskeleton|axon guidance|T cell proliferation|regulation of neuron projection development|protein localization to organelle|positive regulation of protein modification process|regulation of T cell activation|regulation of I-kappaB kinase/NF-kappaB signaling|fibroblast growth factor receptor signaling pathway|sensory perception of pain|sensory perception of mechanical stimulus|cellular response to peptide|regulation of MAPK cascade|regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|detection of mechanical stimulus involved in sensory perception of pain|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|ATP binding|cation transport|extrinsic apoptotic signaling pathway in absence of ligand|regulation of extrinsic apoptotic signaling pathway|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|axon development|inositol lipid-mediated signaling|response to ethanol|enzyme linked receptor protein signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|response to insulin|neuron apoptotic process|Fc receptor mediated stimulatory signaling pathway|regulation of phosphatidylinositol 3-kinase signaling|negative regulation of neuron apoptotic process|endocytosis|regulation of protein localization to nucleus|peptide hormone receptor binding|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|positive regulation of T cell activation|antigen receptor-mediated signaling pathway|regulation of neurogenesis|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|positive regulation of neuron projection development|regulation of kinase activity|apoptotic process|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|positive regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|JAK-STAT cascade|Ras protein signal transduction|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of JAK-STAT cascade|regulation of MAP kinase activity|regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of phosphorylation|protein tyrosine kinase activity|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|positive regulation of JAK-STAT cascade|metal ion transport|positive regulation of protein phosphorylation|activated T cell proliferation|T cell receptor signaling pathway|lymphocyte aggregation|regulation of neuron differentiation|positive regulation of phosphorylation|protein localization to nucleus|transmembrane receptor protein tyrosine kinase signaling pathway|non-membrane spanning protein tyrosine kinase activity|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|Fc-gamma receptor signaling pathway|regulation of peptidyl-tyrosine phosphorylation|ephrin receptor signaling pathway|protein autophosphorylation|Fc-epsilon receptor signaling pathway|regulation of protein ubiquitination|tyrosine phosphorylation of STAT protein|negative regulation of protein ubiquitination|phosphatidylinositol 3-kinase signaling|positive regulation of tyrosine phosphorylation of STAT protein|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation|epidermal growth factor receptor signaling pathway|tyrosine phosphorylation of Stat5 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|calcium ion transport|protein ubiquitination K05703 tyrosine-protein kinase Fyn[2.7.10.2] hsa04510|hsa04360|hsa04072|hsa05162|hsa04650|hsa04380|hsa04611|hsa04071|hsa04725|hsa04660|hsa04520|hsa04664|hsa05416|hsa05130|hsa05020 Focal adhesion - Homo sapiens (human)|Axon guidance - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Measles - Homo sapiens (human)|Natural killer cell mediated cytotoxicity - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Viral myocarditis - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human)|Prion diseases - Homo sapiens (human) 6:111660332-111873452 67 79 184 287 367 316 0.323396835950065 0.346552527390267 0.800738848558621 1.24119382976098 1.45343032073189 1.42947148816948 0.490229403966318 1.37469854622078 -1.48758636399942 7.95879555623729e-06 8.23291346278268e-05 DOWN ENSG00000174652 ZNF266 zinc finger protein 266 [Source:HGNC Symbol;Acc:HGNC:13059] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:9412598-9435578 192 317 245 137 84 108 0.975612865134449 1.46391101097068 1.12241856726496 0.62372590152878 0.350206073451908 0.514314863770475 1.18731414779003 0.496082279583721 1.25905037456297 8.02377909148567e-06 8.29495044084817e-05 UP ENSG00000068001 HYAL2 hyaluronoglucosaminidase 2 [Source:HGNC Symbol;Acc:HGNC:5321] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0040013|GO:0042995|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0071704|GO:0009056|GO:0009628|GO:0009986|GO:0044237|GO:0051641|GO:0045177|GO:0048870|GO:0023051|GO:0000989|GO:0045926|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0071944|GO:0040008|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0030234|GO:0005622|GO:0002520|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0031225|GO:0016032|GO:0060341|GO:0004857|GO:0003014|GO:0009897|GO:0003712|GO:0006725|GO:0001822|GO:0009888|GO:0009314|GO:0019838|GO:0006810|GO:1901360|GO:0010941|GO:0016324|GO:0007275|GO:0048513|GO:0005102|GO:0016798|GO:0034641|GO:0044281|GO:0032940|GO:0006952|GO:0001618|GO:0046658|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0010942|GO:0098542|GO:0001817|GO:0043231|GO:0019899|GO:0030308|GO:0005737|GO:0001816|GO:0009611|GO:0001076|GO:0003097|GO:0032880|GO:0005975|GO:0051222|GO:0071559|GO:0006928|GO:0009887|GO:0005667|GO:0042592|GO:0009615|GO:0001775|GO:0009966|GO:0045184|GO:0006979|GO:0048871|GO:0001819|GO:0032388|GO:0010646|GO:0006139|GO:0031226|GO:1900182|GO:0008104|GO:0007154|GO:0044092|GO:0061024|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0009968|GO:0051649|GO:0019955|GO:0008219|GO:0051271|GO:0090316|GO:0051607|GO:0051047|GO:0050790|GO:0019207|GO:0043086|GO:0048869|GO:2000145|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0005539|GO:0010033|GO:0098857|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0050878|GO:0005794|GO:0007568|GO:0051701|GO:0009636|GO:0071774|GO:0003713|GO:0061025|GO:0000165|GO:0019048|GO:2001235|GO:0032268|GO:0042307|GO:0005829|GO:0048705|GO:0030214|GO:0042117|GO:0019210|GO:0010468|GO:0034645|GO:0051216|GO:0007166|GO:0050431|GO:0032675|GO:0044798|GO:0043412|GO:0072594|GO:0030097|GO:0034097|GO:0001104|GO:0031410|GO:0032635|GO:0001655|GO:0050727|GO:0050891|GO:0005540|GO:0060586|GO:0031362|GO:0019887|GO:0048878|GO:0051252|GO:0032386|GO:0051223|GO:0070295|GO:0015031|GO:0005773|GO:0010628|GO:0030334|GO:0032755|GO:0001667|GO:0016023|GO:0030971|GO:0036211|GO:0003091|GO:0032269|GO:0071560|GO:0070201|GO:0046907|GO:0072001|GO:0006954|GO:0050714|GO:0032757|GO:0010259|GO:0050715|GO:0051046|GO:0044344|GO:0071478|GO:0009306|GO:0050729|GO:0070293|GO:0048471|GO:0070848|GO:0031988|GO:1904591|GO:0030336|GO:0034613|GO:0046677|GO:0050663|GO:0019900|GO:0012501|GO:0000302|GO:0006796|GO:0004553|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0017038|GO:0046903|GO:0019058|GO:0071310|GO:0000139|GO:1902532|GO:0005902|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0001501|GO:0031233|GO:0061448|GO:0045121|GO:0043068|GO:0050707|GO:0001191|GO:1903827|GO:1902531|GO:0016070|GO:0010557|GO:0005634|GO:0009416|GO:0043067|GO:0006606|GO:0097190|GO:0032637|GO:0042044|GO:0051896|GO:0043491|GO:1904589|GO:0045893|GO:0072606|GO:0010764|GO:0019087|GO:0033365|GO:0033157|GO:0051898|GO:0070555|GO:2000484|GO:0043065|GO:0009411|GO:0030139|GO:0051169|GO:0035810|GO:0043408|GO:0000323|GO:0046718|GO:0032774|GO:2001141|GO:2001236|GO:0050708|GO:0071363|GO:0016310|GO:0006605|GO:2001238|GO:0030104|GO:0016482|GO:0006886|GO:0001105|GO:0010762|GO:0071482|GO:0004860|GO:0042981|GO:0071345|GO:0050801|GO:0043409|GO:0033673|GO:0002244|GO:0090575|GO:0034612|GO:0042306|GO:0030203|GO:0033906|GO:1900180|GO:0019901|GO:0030260|GO:0006464|GO:2000482|GO:0097191|GO:0010761|GO:0043549|GO:0006351|GO:2000778|GO:0006915|GO:0006355|GO:0006833|GO:0046824|GO:1903533|GO:0010224|GO:0045944|GO:0006366|GO:0019064|GO:0006913|GO:0045859|GO:0006469|GO:0071347|GO:0006357|GO:0005764|GO:0006027|GO:0006468|GO:0043407|GO:0071356|GO:1903506|GO:0043405|GO:0001190|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:1990782|GO:0004415|GO:0030292|GO:0001933|GO:0034644|GO:0034504|GO:0046822|GO:0051170|GO:0050730|GO:0030212|GO:0061097|GO:0061099|GO:0055065|GO:0071901|GO:0030294|GO:0071900|GO:0050732|GO:0071493|GO:0018108|GO:0055072 locomotion|developmental process|growth|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|negative regulation of locomotion|cell projection|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|organic substance metabolic process|catabolic process|response to abiotic stimulus|cell surface|cellular metabolic process|cellular localization|apical part of cell|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|negative regulation of growth|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|cell periphery|regulation of growth|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|intracellular|immune system development|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|anchored component of membrane|viral process|regulation of cellular localization|enzyme inhibitor activity|renal system process|external side of plasma membrane|transcription cofactor activity|cellular aromatic compound metabolic process|kidney development|tissue development|response to radiation|growth factor binding|transport|organic cyclic compound metabolic process|regulation of cell death|apical plasma membrane|multicellular organism development|animal organ development|receptor binding|hydrolase activity, acting on glycosyl bonds|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|defense response|virus receptor activity|anchored component of plasma membrane|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell death|defense response to other organism|regulation of cytokine production|intracellular membrane-bounded organelle|enzyme binding|negative regulation of cell growth|cytoplasm|cytokine production|response to wounding|transcription factor activity, RNA polymerase II transcription factor binding|renal water transport|regulation of protein localization|carbohydrate metabolic process|positive regulation of protein transport|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|transcription factor complex|homeostatic process|response to virus|cell activation|regulation of signal transduction|establishment of protein localization|response to oxidative stress|multicellular organismal homeostasis|positive regulation of cytokine production|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of protein localization to nucleus|protein localization|cell communication|negative regulation of molecular function|membrane organization|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|establishment of localization in cell|cytokine binding|cell death|negative regulation of cellular component movement|positive regulation of intracellular protein transport|defense response to virus|positive regulation of secretion|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|glycosaminoglycan binding|response to organic substance|membrane microdomain|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|regulation of body fluid levels|Golgi apparatus|aging|interaction with host|response to toxic substance|response to fibroblast growth factor|transcription coactivator activity|membrane fusion|MAPK cascade|modulation by virus of host morphology or physiology|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|positive regulation of protein import into nucleus|cytosol|skeletal system morphogenesis|hyaluronan catabolic process|monocyte activation|kinase inhibitor activity|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|cell surface receptor signaling pathway|transforming growth factor beta binding|regulation of interleukin-6 production|nuclear transcription factor complex|macromolecule modification|establishment of protein localization to organelle|hemopoiesis|response to cytokine|RNA polymerase II transcription cofactor activity|cytoplasmic vesicle|interleukin-6 production|urogenital system development|regulation of inflammatory response|multicellular organismal water homeostasis|hyaluronic acid binding|multicellular organismal iron ion homeostasis|anchored component of external side of plasma membrane|protein kinase regulator activity|chemical homeostasis|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|renal water absorption|protein transport|vacuole|positive regulation of gene expression|regulation of cell migration|positive regulation of interleukin-6 production|ameboidal-type cell migration|cytoplasmic, membrane-bounded vesicle|receptor tyrosine kinase binding|protein modification process|renal water homeostasis|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|regulation of establishment of protein localization|intracellular transport|renal system development|inflammatory response|positive regulation of protein secretion|positive regulation of interleukin-8 production|multicellular organism aging|positive regulation of cytokine secretion|regulation of secretion|cellular response to fibroblast growth factor stimulus|cellular response to radiation|protein secretion|positive regulation of inflammatory response|renal absorption|perinuclear region of cytoplasm|response to growth factor|membrane-bounded vesicle|positive regulation of protein import|negative regulation of cell migration|cellular protein localization|response to antibiotic|cytokine secretion|kinase binding|programmed cell death|response to reactive oxygen species|phosphate-containing compound metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|protein import|secretion|viral life cycle|cellular response to organic substance|Golgi membrane|negative regulation of intracellular signal transduction|microvillus|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|intrinsic component of external side of plasma membrane|connective tissue development|membrane raft|positive regulation of programmed cell death|regulation of cytokine secretion|transcriptional repressor activity, RNA polymerase II transcription factor binding|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|regulation of programmed cell death|protein import into nucleus|apoptotic signaling pathway|interleukin-8 production|fluid transport|regulation of protein kinase B signaling|protein kinase B signaling|regulation of protein import|positive regulation of transcription, DNA-templated|interleukin-8 secretion|negative regulation of fibroblast migration|transformation of host cell by virus|protein localization to organelle|regulation of intracellular protein transport|negative regulation of protein kinase B signaling|response to interleukin-1|positive regulation of interleukin-8 secretion|positive regulation of apoptotic process|response to UV|endocytic vesicle|nuclear transport|positive regulation of urine volume|regulation of MAPK cascade|lytic vacuole|viral entry into host cell|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of extrinsic apoptotic signaling pathway|regulation of protein secretion|cellular response to growth factor stimulus|phosphorylation|protein targeting|positive regulation of extrinsic apoptotic signaling pathway|water homeostasis|cytosolic transport|intracellular protein transport|RNA polymerase II transcription coactivator activity|regulation of fibroblast migration|cellular response to light stimulus|protein kinase inhibitor activity|regulation of apoptotic process|cellular response to cytokine stimulus|ion homeostasis|negative regulation of MAPK cascade|negative regulation of kinase activity|hematopoietic progenitor cell differentiation|RNA polymerase II transcription factor complex|response to tumor necrosis factor|regulation of protein import into nucleus|glycosaminoglycan metabolic process|hyaluronoglucuronidase activity|regulation of protein localization to nucleus|protein kinase binding|entry into host cell|cellular protein modification process|regulation of interleukin-8 secretion|extrinsic apoptotic signaling pathway|fibroblast migration|regulation of kinase activity|transcription, DNA-templated|positive regulation of interleukin-6 secretion|apoptotic process|regulation of transcription, DNA-templated|water transport|positive regulation of nucleocytoplasmic transport|regulation of protein targeting|response to UV-B|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|fusion of virus membrane with host plasma membrane|nucleocytoplasmic transport|regulation of protein kinase activity|negative regulation of protein kinase activity|cellular response to interleukin-1|regulation of transcription from RNA polymerase II promoter|lysosome|glycosaminoglycan catabolic process|protein phosphorylation|negative regulation of MAP kinase activity|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|transcriptional activator activity, RNA polymerase II transcription factor binding|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|protein tyrosine kinase binding|hyalurononglucosaminidase activity|protein tyrosine kinase inhibitor activity|negative regulation of protein phosphorylation|cellular response to UV|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import|regulation of peptidyl-tyrosine phosphorylation|hyaluronan metabolic process|regulation of protein tyrosine kinase activity|negative regulation of protein tyrosine kinase activity|metal ion homeostasis|negative regulation of protein serine/threonine kinase activity|receptor signaling protein tyrosine kinase inhibitor activity|regulation of protein serine/threonine kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|cellular response to UV-B|peptidyl-tyrosine phosphorylation|iron ion homeostasis K01197 hyaluronoglucosaminidase[3.2.1.35] hsa01100|hsa00531 Metabolic pathways - Homo sapiens (human)|Glycosaminoglycan degradation - Homo sapiens (human) 3:50317790-50322906 208 264 360 551 672 600 1.29746417131458 1.49663560395717 2.02464708850381 3.079511781256 3.43929750842101 3.50762380210841 1.60624895459185 3.34214436392847 -1.05707853661267 8.04308986891722e-06 8.30572137484105e-05 DOWN ENSG00000165669 FAM204A family with sequence similarity 204 member A [Source:HGNC Symbol;Acc:HGNC:25794] - - - - - - 10:118297930-118342328 173 251 252 532 544 441 0.704436426899504 0.928859270464213 0.925147859374244 1.94090832713673 1.8174497633484 1.6829196743377 0.852814518912654 1.81375925494094 -1.08867907097736 8.04137875561408e-06 8.30572137484105e-05 DOWN ENSG00000196843 ARID5A AT-rich interaction domain 5A [Source:HGNC Symbol;Acc:HGNC:17361] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212 cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding - - - - 2:96536743-96552638 394 423 565 226 310 180 3.87518757237973 3.78108442771194 5.01023797650361 1.9915961823482 2.50164242079981 1.65919285591598 4.22216999219843 2.05081048635466 1.04179048560459 8.07637550215425e-06 8.33721003600667e-05 UP ENSG00000249992 TMEM158 transmembrane protein 158 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:30293] GO:0016020|GO:0005488|GO:0033218|GO:0031224|GO:0042277|GO:0016021 membrane|binding|amide binding|intrinsic component of membrane|peptide binding|integral component of membrane - - - - 3:45224466-45226278 182 213 187 99 109 71 7.10099547992616 7.55279965113054 6.5781551879722 3.46082735484527 3.48933265487841 2.59616770867137 7.07731677300963 3.18210923946502 1.15321913102972 8.08674324325763e-06 8.34502705787118e-05 UP ENSG00000102103 PQBP1 polyglutamine binding protein 1 [Source:HGNC Symbol;Acc:HGNC:9330] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0019222|GO:0045595|GO:0003712|GO:0006725|GO:0048468|GO:0008022|GO:1901360|GO:0007275|GO:0003676|GO:0043021|GO:0016358|GO:0034641|GO:0046483|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0030529|GO:0097546|GO:0043005|GO:0072372|GO:0006139|GO:0032838|GO:0030030|GO:0048869|GO:0071598|GO:0044249|GO:0022613|GO:0031323|GO:0006996|GO:0003713|GO:0035770|GO:0000902|GO:0031175|GO:0003677|GO:0005813|GO:0031344|GO:0010468|GO:0034645|GO:0050773|GO:0048813|GO:0051252|GO:0005815|GO:0000904|GO:0022618|GO:0031981|GO:0005654|GO:0022604|GO:0070925|GO:0010467|GO:0032990|GO:0007399|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0005856|GO:0005634|GO:0036464|GO:0051960|GO:0048666|GO:0030182|GO:0060271|GO:0010975|GO:0034622|GO:0006396|GO:0010769|GO:0032774|GO:2001141|GO:0034063|GO:0043484|GO:0016604|GO:0015630|GO:0016071|GO:0048814|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0010494|GO:0006351|GO:0006355|GO:0016607|GO:0048699|GO:1903506|GO:0006397|GO:0008380|GO:0045664|GO:0000375|GO:0000398|GO:0000380 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|cilium|regulation of metabolic process|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|protein C-terminus binding|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|ribonucleoprotein complex binding|dendrite development|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|ciliary base|neuron projection|primary cilium|nucleobase-containing compound metabolic process|cell projection cytoplasm|cell projection organization|cellular developmental process|neuronal ribonucleoprotein granule|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|organelle organization|transcription coactivator activity|ribonucleoprotein granule|cell morphogenesis|neuron projection development|DNA binding|centrosome|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of dendrite development|dendrite morphogenesis|regulation of RNA metabolic process|microtubule organizing center|cell morphogenesis involved in differentiation|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|regulation of cell morphogenesis|organelle assembly|gene expression|cell part morphogenesis|nervous system development|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|cytoskeleton|nucleus|cytoplasmic ribonucleoprotein granule|regulation of nervous system development|neuron development|neuron differentiation|cilium morphogenesis|regulation of neuron projection development|cellular macromolecular complex assembly|RNA processing|regulation of cell morphogenesis involved in differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|stress granule assembly|regulation of RNA splicing|nuclear body|microtubule cytoskeleton|mRNA metabolic process|regulation of dendrite morphogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|cytoplasmic stress granule|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|generation of neurons|regulation of nucleic acid-templated transcription|mRNA processing|RNA splicing|regulation of neuron differentiation|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome|alternative mRNA splicing, via spliceosome K12865 polyglutamine-binding protein 1[-] hsa03040 Spliceosome - Homo sapiens (human) X:48897912-48903143 716 687 569 378 400 244 7.71244350008322 6.72535510171747 5.52592412593281 3.64810853489066 3.53514453505778 2.46318971492689 6.65457424257783 3.21548092829178 1.04931183337844 8.1486075570006e-06 8.40305803131937e-05 UP ENSG00000135336 ORC3 origin recognition complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:8489] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0008283|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0006725|GO:0000808|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0061351|GO:0044249|GO:0003677|GO:0034645|GO:1903047|GO:0005664|GO:0044770|GO:0000278|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0009059|GO:0005634|GO:0006260|GO:0000781|GO:0044772|GO:0043565|GO:0003690|GO:0000784|GO:0000082|GO:0003688 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|cell proliferation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|cell cycle|cellular aromatic compound metabolic process|origin recognition complex|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|neural precursor cell proliferation|cellular biosynthetic process|DNA binding|cellular macromolecule biosynthetic process|mitotic cell cycle process|nuclear origin of replication recognition complex|cell cycle phase transition|mitotic cell cycle|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|macromolecule biosynthetic process|nucleus|DNA replication|chromosome, telomeric region|mitotic cell cycle phase transition|sequence-specific DNA binding|double-stranded DNA binding|nuclear chromosome, telomeric region|G1/S transition of mitotic cell cycle|DNA replication origin binding K02605 origin recognition complex subunit 3[-] hsa04110 Cell cycle - Homo sapiens (human) 6:87590067-87667453 180 244 279 585 620 417 2.75240762628832 3.39085640019303 3.84644242169991 8.0148180868706 7.77857386557141 5.9759211291133 3.32990214939375 7.25643769385177 -1.12378169527361 8.33046456848581e-06 8.58170080150364e-05 DOWN ENSG00000232611 RP11-1114A5.4 - - - - - - - X:136840931-136847797 39 51 39 17 13 15 0.914084939165601 1.08637602077217 0.82415859963385 0.357005445729015 0.249991130054003 0.329498745582033 0.94153985319054 0.312165107121684 1.59271287584698 8.33709265929736e-06 8.58421243348299e-05 UP ENSG00000107036 RIC1 RIC1 homolog, RAB6A GEF complex partner 1 [Source:HGNC Symbol;Acc:HGNC:17686] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0043227|GO:0009893|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0005085|GO:0019222|GO:0006810|GO:0032045|GO:0043231|GO:0019899|GO:0005737|GO:0005088|GO:0043085|GO:0051649|GO:0050790|GO:0016021|GO:0019538|GO:0031324|GO:0031323|GO:0005794|GO:0016192|GO:0032268|GO:0005829|GO:0030163|GO:0051345|GO:0044265|GO:0017112|GO:0032269|GO:0046907|GO:0034066|GO:0044267|GO:0042176|GO:0051246|GO:0051020|GO:0042177|GO:0044257|GO:1903363|GO:0042147|GO:0043087|GO:0016482|GO:0043547|GO:0016197|GO:0031267|GO:0017016|GO:0017137 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|positive regulation of metabolic process|intrinsic component of membrane|intracellular|protein binding|protein complex|endomembrane system|guanyl-nucleotide exchange factor activity|regulation of metabolic process|transport|guanyl-nucleotide exchange factor complex|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|Ras guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|establishment of localization in cell|regulation of catalytic activity|integral component of membrane|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|vesicle-mediated transport|regulation of cellular protein metabolic process|cytosol|protein catabolic process|positive regulation of hydrolase activity|cellular macromolecule catabolic process|Rab guanyl-nucleotide exchange factor activity|negative regulation of cellular protein metabolic process|intracellular transport|RIC1-RGP1 guanyl-nucleotide exchange factor complex|cellular protein metabolic process|regulation of protein catabolic process|regulation of protein metabolic process|GTPase binding|negative regulation of protein catabolic process|cellular protein catabolic process|negative regulation of cellular protein catabolic process|retrograde transport, endosome to Golgi|regulation of GTPase activity|cytosolic transport|positive regulation of GTPase activity|endosomal transport|small GTPase binding|Ras GTPase binding|Rab GTPase binding - - - - 9:5629025-5776557 97 116 194 317 315 418 0.474972572355119 0.516220894446356 0.856472957607208 1.39076955801884 1.26554147761429 1.91824012797009 0.615888808136228 1.52485038786774 -1.3079258812136 8.37186903014843e-06 8.61543529907105e-05 DOWN ENSG00000221909 FAM200A family with sequence similarity 200 member A [Source:HGNC Symbol;Acc:HGNC:25401] GO:0016020|GO:0005488|GO:0097159|GO:0031224|GO:0005515|GO:0003676|GO:0016021 membrane|binding|organic cyclic compound binding|intrinsic component of membrane|protein binding|nucleic acid binding|integral component of membrane - - - - 7:99546308-99558536 437 418 333 200 231 179 6.98891965153729 6.07554897543902 4.80161066106688 2.86586518062008 3.03115384062674 2.68293675658376 5.95535976268106 2.85998525927686 1.05818095259205 8.39302875987767e-06 8.63423434174321e-05 UP ENSG00000093009 CDC45 cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0031261|GO:0034641|GO:0046483|GO:0051128|GO:0033554|GO:0016817|GO:0022607|GO:0043231|GO:0005737|GO:0009890|GO:0045787|GO:0003682|GO:0016458|GO:0006139|GO:0060968|GO:0031298|GO:0044249|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0005813|GO:0010468|GO:0000075|GO:0034645|GO:0090068|GO:0000725|GO:1903047|GO:0010629|GO:0051252|GO:0006325|GO:0005815|GO:0044770|GO:0006302|GO:0016818|GO:0033260|GO:0000278|GO:0005657|GO:0031981|GO:0007346|GO:0010564|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0006342|GO:0033043|GO:0010467|GO:0009059|GO:0005656|GO:0016070|GO:0045931|GO:0005856|GO:0005634|GO:0006974|GO:0000083|GO:0031938|GO:0045814|GO:0006270|GO:0000724|GO:0006260|GO:0043596|GO:0034622|GO:1902977|GO:0045892|GO:0003697|GO:0032774|GO:0044772|GO:0043565|GO:2001141|GO:0022616|GO:0033044|GO:1902679|GO:0006267|GO:0003690|GO:1901990|GO:0040029|GO:1901989|GO:0015630|GO:1901992|GO:0065004|GO:0006310|GO:0016568|GO:1901987|GO:0006348|GO:0071103|GO:0016462|GO:0006351|GO:0006355|GO:1900087|GO:2000045|GO:0006366|GO:0006271|GO:1903507|GO:0006357|GO:0006261|GO:0032392|GO:1903506|GO:1902808|GO:0017111|GO:0000727|GO:1902806|GO:0000082|GO:0000076|GO:0032508|GO:0003688|GO:0004386|GO:0003678|GO:0043138 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|regulation of metabolic process|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|DNA replication preinitiation complex|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|negative regulation of biosynthetic process|positive regulation of cell cycle|chromatin binding|gene silencing|nucleobase-containing compound metabolic process|regulation of gene silencing|replication fork protection complex|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|centrosome|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|recombinational repair|mitotic cell cycle process|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|microtubule organizing center|cell cycle phase transition|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nuclear DNA replication|mitotic cell cycle|replication fork|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|chromatin silencing|regulation of organelle organization|gene expression|macromolecule biosynthetic process|nuclear pre-replicative complex|RNA metabolic process|positive regulation of mitotic cell cycle|cytoskeleton|nucleus|cellular response to DNA damage stimulus|regulation of transcription involved in G1/S transition of mitotic cell cycle|regulation of chromatin silencing at telomere|negative regulation of gene expression, epigenetic|DNA replication initiation|double-strand break repair via homologous recombination|DNA replication|nuclear replication fork|cellular macromolecular complex assembly|mitotic DNA replication preinitiation complex assembly|negative regulation of transcription, DNA-templated|single-stranded DNA binding|RNA biosynthetic process|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of RNA biosynthetic process|DNA strand elongation|regulation of chromosome organization|negative regulation of RNA biosynthetic process|pre-replicative complex assembly involved in nuclear cell cycle DNA replication|double-stranded DNA binding|regulation of mitotic cell cycle phase transition|regulation of gene expression, epigenetic|positive regulation of cell cycle phase transition|microtubule cytoskeleton|positive regulation of mitotic cell cycle phase transition|protein-DNA complex assembly|DNA recombination|chromatin modification|regulation of cell cycle phase transition|chromatin silencing at telomere|DNA conformation change|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of G1/S transition of mitotic cell cycle|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|DNA strand elongation involved in DNA replication|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication|DNA geometric change|regulation of nucleic acid-templated transcription|positive regulation of cell cycle G1/S phase transition|nucleoside-triphosphatase activity|double-strand break repair via break-induced replication|regulation of cell cycle G1/S phase transition|G1/S transition of mitotic cell cycle|DNA replication checkpoint|DNA duplex unwinding|DNA replication origin binding|helicase activity|DNA helicase activity|3'-5' DNA helicase activity K06628 cell division control protein 45[-] hsa04110 Cell cycle - Homo sapiens (human) 22:19479459-19520612 222 271 299 623 688 461 3.28664291438479 3.64627234995515 3.99102907793309 8.26390890554858 8.35710308442891 6.39630316526784 3.64131478075768 7.67243838508178 -1.07522569207308 8.40948804220426e-06 8.64223256495579e-05 DOWN ENSG00000152952 PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 [Source:HGNC Symbol;Acc:HGNC:9082] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0016491|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0044237|GO:0006914|GO:0016043|GO:0030246|GO:0043227|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0048029|GO:0051213|GO:0043168|GO:0043062|GO:0030867|GO:0031982|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0043177|GO:0019842|GO:0000422|GO:0005783|GO:0070062|GO:0009725|GO:0016236|GO:0001666|GO:0019538|GO:0010033|GO:0006996|GO:0055114|GO:1903008|GO:0046872|GO:0000423|GO:0043412|GO:0007005|GO:0036211|GO:0005791|GO:0031418|GO:0016706|GO:0044267|GO:0031406|GO:0071310|GO:0030198|GO:0032870|GO:0070815|GO:0046914|GO:0006464|GO:0098779|GO:0005506|GO:0008475 cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|oxidoreductase activity|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|autophagy|cellular component organization|carbohydrate binding|membrane-bounded organelle|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|monosaccharide binding|dioxygenase activity|anion binding|extracellular structure organization|rough endoplasmic reticulum membrane|vesicle|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|organic acid binding|vitamin binding|mitophagy|endoplasmic reticulum|extracellular exosome|response to hormone|macroautophagy|response to hypoxia|protein metabolic process|response to organic substance|organelle organization|oxidation-reduction process|organelle disassembly|metal ion binding|macromitophagy|macromolecule modification|mitochondrion organization|protein modification process|rough endoplasmic reticulum|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|cellular protein metabolic process|carboxylic acid binding|cellular response to organic substance|extracellular matrix organization|cellular response to hormone stimulus|peptidyl-lysine 5-dioxygenase activity|transition metal ion binding|cellular protein modification process|mitophagy in response to mitochondrial depolarization|iron ion binding|procollagen-lysine 5-dioxygenase activity K13645 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2[1.14.11.4] hsa00310 Lysine degradation - Homo sapiens (human) 3:146069440-146163653 1304 1245 2461 3335 3828 4301 7.4610428735813 6.47397738108996 12.695436458801 17.0968206958789 17.9705635238868 23.0632381605411 8.87681890449075 19.3768741267689 -1.12622118394364 8.40746373713769e-06 8.64223256495579e-05 DOWN ENSG00000260328 RP11-416I2.1 - - - - - - - 17:17011914-17014990 158 171 217 86 101 89 3.63224992960717 3.5726873838735 4.49771536150188 1.77138803040353 1.90504668399952 1.91751934444957 3.90088422499418 1.86465135295087 1.06489527620424 8.4062682088043e-06 8.64223256495579e-05 UP ENSG00000133316 WDR74 WD repeat domain 74 [Source:HGNC Symbol;Acc:HGNC:25529] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0001824|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0001825|GO:0043231|GO:0006139|GO:0005730|GO:0009790|GO:0031981|GO:0016070|GO:0005634|GO:0009792|GO:0043009|GO:0001701 developmental process|cell|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|blastocyst development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|blastocyst formation|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleolus|embryo development|nuclear lumen|RNA metabolic process|nucleus|embryo development ending in birth or egg hatching|chordate embryonic development|in utero embryonic development - - - - 11:62832342-62841809 2125 2352 1619 1173 1200 665 18.1147037593347 18.2217301805156 12.4432348607318 8.95917178096425 8.39308560663105 5.31279724023431 16.259889600194 7.55501820927654 1.1058103242534 8.41860922046016e-06 8.64862903192077e-05 UP ENSG00000238083 LRRC37A2 leucine-rich repeat containing 37 member A2 [Source:HGNC Symbol;Acc:HGNC:32404] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 17:46511511-46555650 66 46 95 169 198 211 0.423918454319948 0.268520466324997 0.550145107491459 0.972578901333771 1.04345580196517 1.27014030631604 0.414194676045468 1.09539166987166 -1.40306589950362 8.45952580477431e-06 8.68767400673313e-05 DOWN ENSG00000184659 FOXD4L4 forkhead box D4-like 4 [Source:HGNC Symbol;Acc:HGNC:23762] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0000981|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 9:65736555-65738784 25 24 11 1 4 5 0.793021733241019 0.691881277981017 0.314585290487435 0.0284075307178529 0.104097160376477 0.14865436934484 0.599829433903157 0.0937196868130566 2.67812827943731 8.49872736744292e-06 8.71893494253062e-05 UP ENSG00000272145 NFYC-AS1 NFYC antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49451] - - - - - - 1:40690380-40692066 18 12 13 50 52 49 0.754754234745625 0.457289641344893 0.491453053811741 1.87843176877157 1.78897994351499 1.92556290694167 0.56783230996742 1.86432487307608 -1.71511643606165 8.50705523190128e-06 8.72448048413537e-05 DOWN ENSG00000188312 CENPP centromere protein P [Source:HGNC Symbol;Acc:HGNC:32933] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0007049|GO:0022607|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0006996|GO:0051276|GO:0005730|GO:0005829|GO:0006325|GO:0000278|GO:0031981|GO:0005654|GO:0005694|GO:0006461|GO:0035556|GO:0005634|GO:0006334|GO:0034622|GO:0034728|GO:0034508|GO:0006333|GO:0065004|GO:0031497|GO:0016568|GO:0007264|GO:0071103|GO:0000775|GO:0006336|GO:0006323|GO:0043486|GO:0006338|GO:0034080|GO:0043044 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|cell cycle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|organelle organization|chromosome organization|nucleolus|cytosol|chromatin organization|mitotic cell cycle|nuclear lumen|nucleoplasm|chromosome|protein complex assembly|intracellular signal transduction|nucleus|nucleosome assembly|cellular macromolecular complex assembly|nucleosome organization|centromere complex assembly|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|chromatin modification|small GTPase mediated signal transduction|DNA conformation change|chromosome, centromeric region|DNA replication-independent nucleosome assembly|DNA packaging|histone exchange|chromatin remodeling|CENP-A containing nucleosome assembly|ATP-dependent chromatin remodeling - - - - 9:92325484-92620533 54 115 139 294 300 254 0.312484553505203 0.604799588003179 0.725205792564226 1.52432341985348 1.42436768826025 1.3775110298145 0.547496644690869 1.44206737930941 -1.39721654642955 8.52151818295613e-06 8.73631194484795e-05 DOWN ENSG00000165490 DDIAS DNA damage-induced apoptosis suppressor [Source:HGNC Symbol;Acc:HGNC:26351] GO:0005623|GO:0009987|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0008219|GO:0012501|GO:0005634|GO:0006915 cell|cellular process|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|cell death|programmed cell death|nucleus|apoptotic process - - - - 11:82899975-82958277 861 686 639 395 460 273 5.77074225778835 4.17861948792471 3.86139289619263 2.37204578205771 2.52961689044091 1.7148251870504 4.60358488063523 2.20549595318301 1.06165463383707 8.53257072721801e-06 8.74464011295457e-05 UP ENSG00000135929 CYP27A1 cytochrome P450 family 27 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2605] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0016491|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0031090|GO:0019866|GO:1901360|GO:0006082|GO:0009410|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0031966|GO:0004497|GO:0006629|GO:0006805|GO:0044249|GO:0055114|GO:0005740|GO:0046872|GO:0020037|GO:0006066|GO:0016709|GO:0008395|GO:0005743|GO:0071466|GO:0005759|GO:0005739|GO:0008202|GO:0008610|GO:0008206|GO:0006699|GO:0006694|GO:0016125|GO:0046914|GO:0019752|GO:0047749|GO:0005506|GO:0032787 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|organelle membrane|organelle inner membrane|organic cyclic compound metabolic process|organic acid metabolic process|response to xenobiotic stimulus|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|mitochondrial membrane|monooxygenase activity|lipid metabolic process|xenobiotic metabolic process|cellular biosynthetic process|oxidation-reduction process|mitochondrial envelope|metal ion binding|heme binding|alcohol metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|steroid hydroxylase activity|mitochondrial inner membrane|cellular response to xenobiotic stimulus|mitochondrial matrix|mitochondrion|steroid metabolic process|lipid biosynthetic process|bile acid metabolic process|bile acid biosynthetic process|steroid biosynthetic process|sterol metabolic process|transition metal ion binding|carboxylic acid metabolic process|cholestanetriol 26-monooxygenase activity|iron ion binding|monocarboxylic acid metabolic process K00488 cholestanetriol 26-monooxygenase[1.14.13.15] hsa01100|hsa03320|hsa00120 Metabolic pathways - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Primary bile acid biosynthesis - Homo sapiens (human) 2:218781749-218815293 33 22 9 2 2 5 0.399573257225743 0.242095283419981 0.0982487322481261 0.0216983405021687 0.0198679106161882 0.0567441361929121 0.246639090964617 0.0327701291037563 2.91194821548155 8.57708877292158e-06 8.78724805170902e-05 UP ENSG00000092850 TEKT2 tektin 2 (testicular) [Source:HGNC Symbol;Acc:HGNC:11725] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0042995|GO:0043229|GO:0048870|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0048856|GO:0005929|GO:0048646|GO:0005874|GO:0022607|GO:0043231|GO:0031514|GO:0005737|GO:0030317|GO:0006928|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0070286|GO:0007010|GO:0035082|GO:0044782|GO:0030031|GO:0006461|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0000226|GO:0005856|GO:0005634|GO:0060271|GO:0036159|GO:0034622|GO:0043623|GO:0015630|GO:0001578 locomotion|developmental process|cell|cellular process|cell projection|intracellular organelle|cell motility|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|microtubule|cellular component assembly|intracellular membrane-bounded organelle|motile cilium|cytoplasm|sperm motility|movement of cell or subcellular component|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|axonemal dynein complex assembly|cytoskeleton organization|axoneme assembly|cilium organization|cell projection assembly|protein complex assembly|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|nucleus|cilium morphogenesis|inner dynein arm assembly|cellular macromolecular complex assembly|cellular protein complex assembly|microtubule cytoskeleton|microtubule bundle formation - - - - 1:36084075-36088275 24 15 11 3 1 3 0.645993824849642 0.366948232817318 0.266942617118333 0.0723403724179914 0.0220940744232696 0.0756686591069841 0.426628224928431 0.0567010353160817 2.91153243186003 8.58923560985119e-06 8.79667375288156e-05 UP ENSG00000173409 ARV1 ARV1 homolog, fatty acid homeostasis modulator [Source:HGNC Symbol;Acc:HGNC:29561] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0019222|GO:0044255|GO:0097035|GO:0006810|GO:1901360|GO:0006082|GO:0005938|GO:0044281|GO:0043231|GO:0005737|GO:0061024|GO:0006629|GO:0005783|GO:0051649|GO:0016021|GO:0010876|GO:0010256|GO:0005794|GO:0006665|GO:0006066|GO:0006643|GO:0007009|GO:0097036|GO:0046907|GO:0032541|GO:0006869|GO:0008202|GO:0071782|GO:0008610|GO:0019216|GO:0008206|GO:0019218|GO:0006694|GO:0016125|GO:0015918|GO:0019752|GO:0032366|GO:0030301|GO:0016126|GO:0090181|GO:0008203|GO:0032787|GO:0006695 cell|membrane|cellular process|metabolic process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|regulation of metabolic process|cellular lipid metabolic process|regulation of membrane lipid distribution|transport|organic cyclic compound metabolic process|organic acid metabolic process|cell cortex|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|membrane organization|lipid metabolic process|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|lipid localization|endomembrane system organization|Golgi apparatus|sphingolipid metabolic process|alcohol metabolic process|membrane lipid metabolic process|plasma membrane organization|regulation of plasma membrane sterol distribution|intracellular transport|cortical endoplasmic reticulum|lipid transport|steroid metabolic process|endoplasmic reticulum tubular network|lipid biosynthetic process|regulation of lipid metabolic process|bile acid metabolic process|regulation of steroid metabolic process|steroid biosynthetic process|sterol metabolic process|sterol transport|carboxylic acid metabolic process|intracellular sterol transport|cholesterol transport|sterol biosynthetic process|regulation of cholesterol metabolic process|cholesterol metabolic process|monocarboxylic acid metabolic process|cholesterol biosynthetic process - - - - 1:230978981-231000595 161 210 317 577 580 456 3.51283176797388 4.16419908593602 6.23600921354261 11.2799203112303 10.3831405495654 9.32452430498493 4.63768002248417 10.3291950552602 -1.15525264113371 8.61003881423767e-06 8.81193345081424e-05 DOWN ENSG00000250874 CTC-480C2.1 - - - - - - - 5:85663232-85664684 4 3 1 18 19 18 0.194724192562051 0.132754529177618 0.0438710790226046 0.785128168417742 0.75893761411647 0.821255643702498 0.123783266920758 0.788440475412237 -2.67118553698346 8.61715667645431e-06 8.81619586767878e-05 DOWN ENSG00000197933 ZNF823 zinc finger protein 823 [Source:HGNC Symbol;Acc:HGNC:30936] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:11721265-11739009 258 224 207 113 113 112 3.63331089646869 2.86688346918407 2.62824798872668 1.42580368919573 1.30565334878242 1.47818439180961 3.04281411812648 1.40321380992925 1.11667135257602 8.74831935644343e-06 8.93507786750811e-05 UP ENSG00000013561 RNF14 ring finger protein 14 [Source:HGNC Symbol;Acc:HGNC:10058] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009725|GO:0019787|GO:0000151|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0003713|GO:0032268|GO:0045732|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0043412|GO:0030163|GO:0004842|GO:0051427|GO:0051252|GO:0044265|GO:0010628|GO:0036211|GO:1990234|GO:0051247|GO:0006508|GO:0033143|GO:0032270|GO:0014070|GO:0044267|GO:0044390|GO:0042176|GO:0010467|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0009755|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0043401|GO:0044257|GO:0045893|GO:0061630|GO:0010498|GO:0032774|GO:1903364|GO:0030162|GO:2001141|GO:0035257|GO:0045862|GO:0071383|GO:0071407|GO:0030518|GO:0051603|GO:0046914|GO:0060765|GO:0031624|GO:0006464|GO:0071396|GO:0006351|GO:0006355|GO:0006366|GO:1903052|GO:0035258|GO:0006357|GO:0019941|GO:1903506|GO:1901800|GO:0030521|GO:0061136|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0050681|GO:0032434|GO:0032436|GO:0042787|GO:0016567|GO:0000209 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|ligase activity|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|response to hormone|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|transcription coactivator activity|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|hormone receptor binding|regulation of RNA metabolic process|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|transferase complex|positive regulation of protein metabolic process|proteolysis|regulation of intracellular steroid hormone receptor signaling pathway|positive regulation of cellular protein metabolic process|response to organic cyclic compound|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein catabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|cellular protein catabolic process|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity|proteasomal protein catabolic process|RNA biosynthetic process|positive regulation of cellular protein catabolic process|regulation of proteolysis|regulation of RNA biosynthetic process|nuclear hormone receptor binding|positive regulation of proteolysis|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|proteolysis involved in cellular protein catabolic process|transition metal ion binding|regulation of androgen receptor signaling pathway|ubiquitin conjugating enzyme binding|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|positive regulation of proteolysis involved in cellular protein catabolic process|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|positive regulation of proteasomal protein catabolic process|androgen receptor signaling pathway|regulation of proteasomal protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|androgen receptor binding|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 5:141958328-141990291 253 327 287 633 692 555 1.61214482368678 1.89370130659522 1.64884247458821 3.61397181862601 3.61791129865686 3.31440796236015 1.71822953495674 3.51543035988101 -1.03277853901639 8.81924570412247e-06 9.00135935900418e-05 DOWN ENSG00000135541 AHI1 Abelson helper integration site 1 [Source:HGNC Symbol;Acc:HGNC:21575] GO:0032502|GO:0032991|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0050795|GO:0005911|GO:0009653|GO:0016043|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0019222|GO:0042802|GO:0007507|GO:0048565|GO:0035844|GO:0045595|GO:0035239|GO:0006725|GO:0060041|GO:0001822|GO:0009888|GO:0048468|GO:0006810|GO:0031623|GO:0035295|GO:0051130|GO:1901360|GO:0048839|GO:0010941|GO:0007275|GO:0070121|GO:0060627|GO:0048513|GO:0072028|GO:0034641|GO:0030902|GO:0005912|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0022607|GO:0045807|GO:0045597|GO:0005737|GO:0007389|GO:0060322|GO:0007423|GO:0009887|GO:0003407|GO:0048729|GO:0048598|GO:0072006|GO:0048568|GO:0072372|GO:0036038|GO:0036064|GO:0060548|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0035869|GO:0008219|GO:0010842|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0006996|GO:0016192|GO:0000902|GO:0005813|GO:0003143|GO:0010468|GO:0034645|GO:0055123|GO:0007166|GO:0001654|GO:0002009|GO:0072358|GO:0007417|GO:0001655|GO:0002090|GO:0043583|GO:0048793|GO:0043069|GO:0009798|GO:0051252|GO:0035050|GO:0005815|GO:0003007|GO:0048260|GO:0009790|GO:0010628|GO:0005814|GO:0044782|GO:0030856|GO:2000027|GO:0072001|GO:0072176|GO:0065001|GO:0003002|GO:0060042|GO:0030031|GO:0030100|GO:0061371|GO:0030858|GO:0002092|GO:0061326|GO:0034613|GO:0070925|GO:0060993|GO:0012501|GO:0060429|GO:0042384|GO:0072073|GO:0010467|GO:0032990|GO:0048562|GO:0007399|GO:0060562|GO:0031328|GO:0071599|GO:0009059|GO:0030154|GO:0048858|GO:0048546|GO:0016070|GO:0072359|GO:0005856|GO:0010557|GO:0043067|GO:0031513|GO:0043112|GO:0048666|GO:0030182|GO:0060271|GO:0042461|GO:0045893|GO:0072178|GO:0030855|GO:0039008|GO:0043010|GO:0048259|GO:0032774|GO:2001141|GO:0072078|GO:0001947|GO:0061333|GO:0007167|GO:0015630|GO:0009855|GO:0072080|GO:0042981|GO:0035845|GO:0070986|GO:0043066|GO:0060972|GO:0039020|GO:0006897|GO:0022008|GO:0030862|GO:0006351|GO:0006915|GO:0006355|GO:0048592|GO:0001738|GO:0045944|GO:0006366|GO:0006357|GO:0048593|GO:0048699|GO:0030859|GO:0007368|GO:1903506|GO:0006898|GO:0039023|GO:0007169 developmental process|macromolecular complex|behavior|signaling|cell|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of behavior|cell-cell junction|anatomical structure morphogenesis|cellular component organization|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|heart development|digestive tract development|cloaca development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|retina development in camera-type eye|kidney development|tissue development|cell development|transport|receptor internalization|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|inner ear development|regulation of cell death|multicellular organism development|Kupffer's vesicle development|regulation of vesicle-mediated transport|animal organ development|nephron morphogenesis|cellular nitrogen compound metabolic process|hindbrain development|adherens junction|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|cellular component assembly|positive regulation of endocytosis|positive regulation of cell differentiation|cytoplasm|pattern specification process|head development|sensory organ development|organ morphogenesis|neural retina development|tissue morphogenesis|embryonic morphogenesis|nephron development|embryonic organ development|primary cilium|TCTN-B9D complex|ciliary basal body|negative regulation of cell death|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|ciliary transition zone|cell death|retina layer formation|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|vesicle-mediated transport|cell morphogenesis|centrosome|embryonic heart tube morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|digestive system development|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|cardiovascular system development|central nervous system development|urogenital system development|regulation of receptor internalization|ear development|pronephros development|negative regulation of programmed cell death|axis specification|regulation of RNA metabolic process|embryonic heart tube development|microtubule organizing center|heart morphogenesis|positive regulation of receptor-mediated endocytosis|embryo development|positive regulation of gene expression|centriole|cilium organization|regulation of epithelial cell differentiation|regulation of organ morphogenesis|renal system development|nephric duct development|specification of axis polarity|regionalization|retina morphogenesis in camera-type eye|cell projection assembly|regulation of endocytosis|determination of heart left/right asymmetry|positive regulation of epithelial cell differentiation|positive regulation of receptor internalization|renal tubule development|cellular protein localization|organelle assembly|kidney morphogenesis|programmed cell death|epithelium development|cilium assembly|kidney epithelium development|gene expression|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|positive regulation of cellular biosynthetic process|otic vesicle development|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|digestive tract morphogenesis|RNA metabolic process|circulatory system development|cytoskeleton|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|nonmotile primary cilium|receptor metabolic process|neuron development|neuron differentiation|cilium morphogenesis|photoreceptor cell development|positive regulation of transcription, DNA-templated|nephric duct morphogenesis|epithelial cell differentiation|pronephric nephron tubule morphogenesis|camera-type eye development|regulation of receptor-mediated endocytosis|RNA biosynthetic process|regulation of RNA biosynthetic process|nephron tubule morphogenesis|heart looping|renal tubule morphogenesis|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|determination of bilateral symmetry|nephron tubule development|regulation of apoptotic process|photoreceptor cell outer segment organization|left/right axis specification|negative regulation of apoptotic process|left/right pattern formation|pronephric nephron tubule development|endocytosis|neurogenesis|positive regulation of polarized epithelial cell differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|eye morphogenesis|morphogenesis of a polarized epithelium|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|camera-type eye morphogenesis|generation of neurons|polarized epithelial cell differentiation|determination of left/right symmetry|regulation of nucleic acid-templated transcription|receptor-mediated endocytosis|pronephric duct morphogenesis|transmembrane receptor protein tyrosine kinase signaling pathway - - - - 6:135283532-135497776 94 118 191 330 311 367 0.42517336286668 0.485063088773592 0.778905784499038 1.33736019310205 1.15415790766523 1.55571972465566 0.563047412046437 1.34907927514098 -1.26064681069874 8.87073767798559e-06 9.05082032257628e-05 DOWN ENSG00000179041 RRS1 ribosome biogenesis regulator homolog [Source:HGNC Symbol;Acc:HGNC:17083] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0002520|GO:0005515|GO:0012505|GO:0048856|GO:0007049|GO:0006725|GO:0051640|GO:0006810|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0071166|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0030529|GO:0051656|GO:0006139|GO:0005783|GO:0051649|GO:0007059|GO:0048869|GO:0022613|GO:0006996|GO:0051276|GO:0005730|GO:0000819|GO:0003723|GO:0030684|GO:1903047|GO:0007080|GO:0030097|GO:0042254|GO:0000278|GO:0046907|GO:0031981|GO:0000054|GO:0005694|GO:0000228|GO:0007067|GO:0042274|GO:0010467|GO:0042273|GO:0030154|GO:0016070|GO:0005634|GO:0051303|GO:0006364|GO:0030687|GO:0090501|GO:0030490|GO:0051169|GO:0006396|GO:0000793|GO:0034660|GO:0000794|GO:0000070|GO:0051310|GO:0044822|GO:0002244|GO:0090305|GO:0000055|GO:0000460|GO:0006913|GO:0000469|GO:0000462|GO:0090502|GO:0016072|GO:0051168|GO:0000479|GO:0000466|GO:0000447 developmental process|macromolecular complex|immune system process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|immune system development|protein binding|endomembrane system|anatomical structure development|cell cycle|cellular aromatic compound metabolic process|organelle localization|transport|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|ribonucleoprotein complex localization|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|establishment of organelle localization|nucleobase-containing compound metabolic process|endoplasmic reticulum|establishment of localization in cell|chromosome segregation|cellular developmental process|ribonucleoprotein complex biogenesis|organelle organization|chromosome organization|nucleolus|sister chromatid segregation|RNA binding|preribosome|mitotic cell cycle process|mitotic metaphase plate congression|hemopoiesis|ribosome biogenesis|mitotic cell cycle|intracellular transport|nuclear lumen|ribosomal subunit export from nucleus|chromosome|nuclear chromosome|mitotic nuclear division|ribosomal small subunit biogenesis|gene expression|ribosomal large subunit biogenesis|cell differentiation|RNA metabolic process|nucleus|establishment of chromosome localization|rRNA processing|preribosome, large subunit precursor|RNA phosphodiester bond hydrolysis|maturation of SSU-rRNA|nuclear transport|RNA processing|condensed chromosome|ncRNA metabolic process|condensed nuclear chromosome|mitotic sister chromatid segregation|metaphase plate congression|poly(A) RNA binding|hematopoietic progenitor cell differentiation|nucleic acid phosphodiester bond hydrolysis|ribosomal large subunit export from nucleus|maturation of 5.8S rRNA|nucleocytoplasmic transport|cleavage involved in rRNA processing|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|RNA phosphodiester bond hydrolysis, endonucleolytic|rRNA metabolic process|nuclear export|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) - - - - 8:66429028-66430733 1004 1084 621 446 489 208 41.629431563542 40.8485094679618 23.2152026321666 16.5691081415402 16.6357882087476 8.08276550839707 35.2310478878901 13.762553952895 1.35609916644182 8.87751453843956e-06 9.05464021286554e-05 UP ENSG00000203780 FANK1 fibronectin type III and ankyrin repeat domains 1 [Source:HGNC Symbol;Acc:HGNC:23527] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0031981|GO:0005654|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nuclear lumen|nucleoplasm|nucleus - - - - 10:125896539-126009592 50 49 97 163 180 199 0.627205296915419 0.558628875072225 1.09705695562988 1.83201388982937 1.85260640183838 2.33950792967284 0.760963709205841 2.00804274044686 -1.39989041931463 8.96137622467902e-06 9.13081658059957e-05 DOWN ENSG00000114480 GBE1 glucan (1,4-alpha-), branching enzyme 1 [Source:HGNC Symbol;Acc:HGNC:4180] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0016740|GO:0044262|GO:0016798|GO:0015980|GO:0044281|GO:0031982|GO:0043169|GO:0005737|GO:0005975|GO:0070062|GO:0016757|GO:0006091|GO:0044249|GO:0055114|GO:0005829|GO:0005976|GO:0034645|GO:0016758|GO:0033692|GO:0005977|GO:0005996|GO:0006112|GO:0004553|GO:0009059|GO:0016051|GO:0005978|GO:0019318|GO:0000271|GO:0003844|GO:0006006 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|transferase activity|cellular carbohydrate metabolic process|hydrolase activity, acting on glycosyl bonds|energy derivation by oxidation of organic compounds|small molecule metabolic process|vesicle|cation binding|cytoplasm|carbohydrate metabolic process|extracellular exosome|transferase activity, transferring glycosyl groups|generation of precursor metabolites and energy|cellular biosynthetic process|oxidation-reduction process|cytosol|polysaccharide metabolic process|cellular macromolecule biosynthetic process|transferase activity, transferring hexosyl groups|cellular polysaccharide biosynthetic process|glycogen metabolic process|monosaccharide metabolic process|energy reserve metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|macromolecule biosynthetic process|carbohydrate biosynthetic process|glycogen biosynthetic process|hexose metabolic process|polysaccharide biosynthetic process|1,4-alpha-glucan branching enzyme activity|glucose metabolic process K00700 1,4-alpha-glucan branching enzyme[2.4.1.18] hsa01100 Metabolic pathways - Homo sapiens (human) 3:81489699-81762161 322 355 561 859 913 853 3.50257841680632 3.5094606585772 5.50185853719527 8.3718783669426 8.14836644210889 8.69581162524744 4.17129920419293 8.40535214476631 -1.01081146348982 8.97136582753145e-06 9.1378763362376e-05 DOWN ENSG00000089682 RBM41 RNA binding motif protein 41 [Source:HGNC Symbol;Acc:HGNC:25617] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0000166|GO:0003723|GO:0005681|GO:0010467|GO:0016070|GO:0005634|GO:0017069|GO:0006396|GO:0005689|GO:0016071|GO:0036002|GO:0030626|GO:0006397|GO:0097157|GO:0008380|GO:0000375|GO:0000398 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|nucleotide binding|RNA binding|spliceosomal complex|gene expression|RNA metabolic process|nucleus|snRNA binding|RNA processing|U12-type spliceosomal complex|mRNA metabolic process|pre-mRNA binding|U12 snRNA binding|mRNA processing|pre-mRNA intronic binding|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - X:107064420-107118823 200 189 248 453 476 465 1.70738295910234 1.46636863596452 1.90882891685524 3.4649447741503 3.33407934511471 3.72034154259124 1.69419350397403 3.50645522061875 -1.04941464120017 8.99730410141177e-06 9.15601544525719e-05 DOWN ENSG00000198846 TOX thymocyte selection associated high mobility group box [Source:HGNC Symbol;Acc:HGNC:18988] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0005622|GO:0003676|GO:0043231|GO:0003677|GO:0005634 cell|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|DNA binding|nucleus - - - - 8:58805418-59119208 3 9 9 22 42 35 0.0513758942916834 0.140066846615709 0.138941925391806 0.337524725039535 0.590077311610265 0.56167590298275 0.110128222099733 0.496425979877517 -2.17239438949635 8.99837519809225e-06 9.15601544525719e-05 DOWN ENSG00000142549 IGLON5 IgLON family member 5 [Source:HGNC Symbol;Acc:HGNC:34550] GO:0005576|GO:0005488|GO:0005515 extracellular region|binding|protein binding - - - - 19:51311848-51330354 41 30 38 108 89 146 1.11290933739333 0.74006871157793 0.929969005188556 2.62658311922102 1.98212534295775 3.71408964309427 0.927649018053272 2.77426603509101 -1.58045517910278 9.00448438309339e-06 9.15722876556817e-05 DOWN ENSG00000196353 CPNE4 copine IV [Source:HGNC Symbol;Acc:HGNC:2317] GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0005515|GO:0031982|GO:0070062 extracellular region|binding|extracellular vesicle|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 3:131533555-132285410 5 3 15 26 43 48 0.0250958525056956 0.0136861310412288 0.0678755077177404 0.116917698990042 0.177069283418293 0.225779684875328 0.0355524970882216 0.173255555761221 -2.28487881722086 9.00570230311119e-06 9.15722876556817e-05 DOWN ENSG00000100330 MTMR3 myotubularin related protein 3 [Source:HGNC Symbol;Acc:HGNC:7451] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0019898|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0009605|GO:0016787|GO:0009058|GO:0005622|GO:0019222|GO:0044255|GO:0010506|GO:1902115|GO:0009991|GO:0016788|GO:0044281|GO:0019637|GO:0051128|GO:0033554|GO:0022607|GO:0043231|GO:0043169|GO:0005737|GO:0031668|GO:0010646|GO:0007154|GO:0006629|GO:0016236|GO:0044249|GO:0019538|GO:0031323|GO:0042594|GO:0006996|GO:0005829|GO:0008654|GO:0046486|GO:0046872|GO:0043412|GO:2000785|GO:0036211|GO:0016241|GO:0031981|GO:0005654|GO:0009267|GO:0070925|GO:0006796|GO:0033043|GO:0044267|GO:0008610|GO:0031669|GO:0030258|GO:0000045|GO:0031667|GO:0005634|GO:0042578|GO:0006644|GO:0007033|GO:0016311|GO:0042149|GO:0046839|GO:0046474|GO:0044088|GO:0016791|GO:0006464|GO:0006650|GO:0006470|GO:0046488|GO:0006661|GO:0004721|GO:0046856|GO:0052866|GO:0035335|GO:0004722|GO:0034593|GO:0004725|GO:1904562|GO:0004438|GO:0052629 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|extrinsic component of membrane|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|response to external stimulus|hydrolase activity|biosynthetic process|intracellular|regulation of metabolic process|cellular lipid metabolic process|regulation of autophagy|regulation of organelle assembly|response to extracellular stimulus|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular response to extracellular stimulus|regulation of cell communication|cell communication|lipid metabolic process|macroautophagy|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|response to starvation|organelle organization|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|metal ion binding|macromolecule modification|regulation of autophagosome assembly|protein modification process|regulation of macroautophagy|nuclear lumen|nucleoplasm|cellular response to starvation|organelle assembly|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|lipid biosynthetic process|cellular response to nutrient levels|lipid modification|autophagosome assembly|response to nutrient levels|nucleus|phosphoric ester hydrolase activity|phospholipid metabolic process|vacuole organization|dephosphorylation|cellular response to glucose starvation|phospholipid dephosphorylation|glycerophospholipid biosynthetic process|regulation of vacuole organization|phosphatase activity|cellular protein modification process|glycerophospholipid metabolic process|protein dephosphorylation|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|phosphoprotein phosphatase activity|phosphatidylinositol dephosphorylation|phosphatidylinositol phosphate phosphatase activity|peptidyl-tyrosine dephosphorylation|protein serine/threonine phosphatase activity|phosphatidylinositol bisphosphate phosphatase activity|protein tyrosine phosphatase activity|phosphatidylinositol 5-phosphate metabolic process|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity K18082 myotubularin-related protein 3/4[3.1.3.95] hsa01100|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 22:29883155-30030866 259 371 581 922 813 1095 1.01539772019265 1.32187660012152 2.0536540685563 3.23866089003648 2.61514179640874 4.02327705200926 1.46364279629016 3.29235991281816 -1.16955855111795 9.01003307120958e-06 9.15851301695236e-05 DOWN ENSG00000125046 SSUH2 ssu-2 homolog (C. elegans) [Source:HGNC Symbol;Acc:HGNC:24809] GO:0005623|GO:0005622|GO:0005737 cell|intracellular|cytoplasm - - - - 3:8619400-8745040 30 25 73 109 159 175 0.184175763703684 0.139490798180403 0.404070271934515 0.599573730290125 0.800906336819618 1.00689865412768 0.242578944606201 0.802459573745808 -1.72597438138179 9.02162096225953e-06 9.16405145312338e-05 DOWN ENSG00000241635 UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 [Source:HGNC Symbol;Acc:HGNC:12530] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0042445|GO:0051707|GO:0043227|GO:0008289|GO:0071944|GO:0009607|GO:0009605|GO:0009058|GO:0031224|GO:0030234|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0019840|GO:0044262|GO:0044255|GO:0070069|GO:0004857|GO:0006725|GO:1901360|GO:0006082|GO:0009991|GO:0007275|GO:0009410|GO:0005496|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0006952|GO:0046483|GO:0005887|GO:0043231|GO:0042168|GO:0019899|GO:0005737|GO:0005975|GO:0043177|GO:0046983|GO:0051186|GO:0008210|GO:0034663|GO:0042493|GO:0031226|GO:0009617|GO:0044092|GO:0009812|GO:0006629|GO:0005783|GO:0016757|GO:0042180|GO:0007586|GO:0009725|GO:0006805|GO:0017144|GO:0050790|GO:0045833|GO:0043086|GO:0010817|GO:0016021|GO:0010033|GO:0031324|GO:0031323|GO:0048732|GO:0042594|GO:0007584|GO:0006109|GO:0033993|GO:0042573|GO:0002237|GO:0046982|GO:0006720|GO:0008194|GO:0006631|GO:0031100|GO:0052696|GO:0001889|GO:0005501|GO:0042167|GO:0006778|GO:0006954|GO:0052697|GO:0051552|GO:0016758|GO:0071466|GO:0005996|GO:0045939|GO:0010565|GO:0008202|GO:0014070|GO:0009813|GO:0031406|GO:0019216|GO:0071310|GO:0045922|GO:0019439|GO:0031667|GO:0032870|GO:0032496|GO:0042178|GO:0042803|GO:0048545|GO:0097305|GO:0019217|GO:0070980|GO:0018879|GO:0019218|GO:0002526|GO:0071383|GO:0071407|GO:2001030|GO:0045471|GO:0015020|GO:1904224|GO:0019752|GO:0071396|GO:0031960|GO:0001972|GO:0051384|GO:0071361|GO:0016101|GO:0032787|GO:0071384|GO:0006953|GO:0006789|GO:0071385|GO:0052695|GO:0001523 developmental process|macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|hormone metabolic process|response to other organism|membrane-bounded organelle|lipid binding|cell periphery|response to biotic stimulus|response to external stimulus|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|isoprenoid binding|cellular carbohydrate metabolic process|cellular lipid metabolic process|cytochrome complex|enzyme inhibitor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|response to xenobiotic stimulus|steroid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|defense response|heterocycle metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|heme metabolic process|enzyme binding|cytoplasm|carbohydrate metabolic process|organic acid binding|protein dimerization activity|cofactor metabolic process|estrogen metabolic process|endoplasmic reticulum chaperone complex|response to drug|intrinsic component of plasma membrane|response to bacterium|negative regulation of molecular function|flavonoid metabolic process|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular ketone metabolic process|digestion|response to hormone|xenobiotic metabolic process|drug metabolic process|regulation of catalytic activity|negative regulation of lipid metabolic process|negative regulation of catalytic activity|regulation of hormone levels|integral component of membrane|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|response to starvation|response to nutrient|regulation of carbohydrate metabolic process|response to lipid|retinoic acid metabolic process|response to molecule of bacterial origin|protein heterodimerization activity|isoprenoid metabolic process|UDP-glycosyltransferase activity|fatty acid metabolic process|organ regeneration|flavonoid glucuronidation|liver development|retinoid binding|heme catabolic process|porphyrin-containing compound metabolic process|inflammatory response|xenobiotic glucuronidation|flavone metabolic process|transferase activity, transferring hexosyl groups|cellular response to xenobiotic stimulus|monosaccharide metabolic process|negative regulation of steroid metabolic process|regulation of cellular ketone metabolic process|steroid metabolic process|response to organic cyclic compound|flavonoid biosynthetic process|carboxylic acid binding|regulation of lipid metabolic process|cellular response to organic substance|negative regulation of fatty acid metabolic process|aromatic compound catabolic process|response to nutrient levels|cellular response to hormone stimulus|response to lipopolysaccharide|xenobiotic catabolic process|protein homodimerization activity|response to steroid hormone|response to alcohol|regulation of fatty acid metabolic process|biphenyl catabolic process|biphenyl metabolic process|regulation of steroid metabolic process|acute inflammatory response|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|negative regulation of cellular glucuronidation|response to ethanol|glucuronosyltransferase activity|negative regulation of glucuronosyltransferase activity|carboxylic acid metabolic process|cellular response to lipid|response to corticosteroid|retinoic acid binding|response to glucocorticoid|cellular response to ethanol|diterpenoid metabolic process|monocarboxylic acid metabolic process|cellular response to corticosteroid stimulus|acute-phase response|bilirubin conjugation|cellular response to glucocorticoid stimulus|cellular glucuronidation|retinoid metabolic process K00699 glucuronosyltransferase[2.4.1.17] hsa01100|hsa05204|hsa00980|hsa00982|hsa00830|hsa00140|hsa00500|hsa00983|hsa00860|hsa00040|hsa00053 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Ascorbate and aldarate metabolism - Homo sapiens (human) 2:233760248-233773299 2 85 15 259 463 393 0.0265366959100225 1.02503303346066 0.179448022092259 3.07917760652182 5.04063967393895 4.88717720952198 0.410339250487647 4.33566482999425 -3.40136416785161 9.10766017969499e-06 9.24830227906851e-05 DOWN ENSG00000004848 ARX aristaless related homeobox [Source:HGNC Symbol;Acc:HGNC:18060] GO:0040011|GO:0032502|GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0048870|GO:0009653|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0048856|GO:0019222|GO:0042127|GO:0006935|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0048857|GO:0034641|GO:0046620|GO:0030900|GO:0046483|GO:0007420|GO:0035265|GO:0043231|GO:0000981|GO:0060322|GO:0021987|GO:0006928|GO:0009890|GO:0048639|GO:0021988|GO:0003682|GO:0006139|GO:0046622|GO:0021772|GO:0016477|GO:0048638|GO:0007586|GO:0061351|GO:0021543|GO:0030030|GO:0048869|GO:0021537|GO:0044249|GO:0031324|GO:0031323|GO:0021536|GO:0000902|GO:0031175|GO:0022029|GO:0003677|GO:0010468|GO:0034645|GO:0021759|GO:0007417|GO:0021895|GO:0010629|GO:0051252|GO:0000904|GO:0010628|GO:0021885|GO:0001764|GO:0003705|GO:0044241|GO:0022028|GO:0021846|GO:0021872|GO:0060429|GO:0021795|GO:0021889|GO:0010467|GO:0032990|GO:0007399|GO:0001227|GO:0097485|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0005634|GO:0045165|GO:0048666|GO:0030182|GO:0007411|GO:0021953|GO:0000975|GO:0021800|GO:0021891|GO:0021892|GO:0001206|GO:0030855|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0061564|GO:0021954|GO:0072148|GO:0021879|GO:0022008|GO:0048667|GO:0021831|GO:0048812|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0007409|GO:0048699|GO:1903506|GO:0021894|GO:0044212|GO:0021884|GO:0000122|GO:0097154|GO:0021853|GO:0035326|GO:0000976|GO:0001012|GO:0021830|GO:0000977|GO:0001158|GO:0000980 locomotion|developmental process|growth|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell motility|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|developmental growth|intracellular|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|chemotaxis|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|neural nucleus development|cellular nitrogen compound metabolic process|regulation of organ growth|forebrain development|heterocycle metabolic process|brain development|organ growth|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|cerebral cortex development|movement of cell or subcellular component|negative regulation of biosynthetic process|positive regulation of developmental growth|olfactory lobe development|chromatin binding|nucleobase-containing compound metabolic process|positive regulation of organ growth|olfactory bulb development|cell migration|regulation of developmental growth|digestion|neural precursor cell proliferation|pallium development|cell projection organization|cellular developmental process|telencephalon development|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|diencephalon development|cell morphogenesis|neuron projection development|telencephalon cell migration|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|globus pallidus development|central nervous system development|cerebral cortex neuron differentiation|negative regulation of gene expression|regulation of RNA metabolic process|cell morphogenesis involved in differentiation|positive regulation of gene expression|forebrain cell migration|neuron migration|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|lipid digestion|tangential migration from the subventricular zone to the olfactory bulb|cell proliferation in forebrain|forebrain generation of neurons|epithelium development|cerebral cortex cell migration|olfactory bulb interneuron differentiation|gene expression|cell part morphogenesis|nervous system development|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|neuron projection guidance|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|nucleus|cell fate commitment|neuron development|neuron differentiation|axon guidance|central nervous system neuron differentiation|regulatory region DNA binding|cerebral cortex tangential migration|olfactory bulb interneuron development|cerebral cortex GABAergic interneuron differentiation|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|epithelial cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|axon development|central nervous system neuron development|epithelial cell fate commitment|forebrain neuron differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|embryonic olfactory bulb interneuron precursor migration|neuron projection morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription|cerebral cortex GABAergic interneuron development|transcription regulatory region DNA binding|forebrain neuron development|negative regulation of transcription from RNA polymerase II promoter|GABAergic neuron differentiation|cerebral cortex GABAergic interneuron migration|enhancer binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|interneuron migration from the subpallium to the cortex|RNA polymerase II regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding - - - - X:25003694-25015948 13 27 18 1 6 4 0.319739029485603 0.603542274267297 0.399167223901545 0.0220267014954145 0.121072670882933 0.0921915791067011 0.440816175884815 0.0784303171616829 2.49069382540879 9.16949340062758e-06 9.30792437886215e-05 UP ENSG00000142227 EMP3 epithelial membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:3335] GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0008283|GO:0050794|GO:0016049|GO:0016043|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0042127|GO:0022607|GO:0008219|GO:0008285|GO:0030030|GO:0016021|GO:0030031|GO:0032060 growth|cell|membrane|cellular process|binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|cell growth|cellular component organization|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|regulation of cell proliferation|cellular component assembly|cell death|negative regulation of cell proliferation|cell projection organization|integral component of membrane|cell projection assembly|bleb assembly - - - - 19:48321509-48330553 188 214 172 86 113 63 3.95435806803304 4.0908363499616 3.26183703539095 1.62074367218307 1.9501328489248 1.241895800193 3.76901048446186 1.60425744043362 1.23228013387311 9.20480928014488e-06 9.33742358985543e-05 UP ENSG00000151240 DIP2C disco interacting protein 2 homolog C [Source:HGNC Symbol;Acc:HGNC:29150] GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043231|GO:0008134|GO:0016021|GO:0005634 cell|membrane|metabolic process|binding|catalytic activity|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|intracellular membrane-bounded organelle|transcription factor binding|integral component of membrane|nucleus - - - - 10:274190-689668 27 37 82 113 184 226 0.154148958113301 0.191982292298906 0.42208771323834 0.578031632835364 0.861908175056911 1.20923990376313 0.256072987883516 0.883059903885135 -1.78595623206402 9.28027825473142e-06 9.40758665591687e-05 DOWN ENSG00000157693 C9orf91 chromosome 9 open reading frame 91 [Source:HGNC Symbol;Acc:HGNC:24513] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 9:114611206-114646422 233 328 211 125 120 121 2.34081553299741 2.99477845219923 1.91120605813961 1.12516944239457 0.98914429768183 1.13926465348807 2.41560001444542 1.08452613118816 1.15531677217831 9.3083959885232e-06 9.43288709576958e-05 UP ENSG00000259248 USP3-AS1 USP3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44140] - - - - - - 15:63544247-63601589 4 8 5 29 28 23 0.0363715454162052 0.0661136928438817 0.0409894441196424 0.236278784739964 0.208905118418135 0.196012815778213 0.0478248941265764 0.213732239645437 -2.15997086249518 9.36692255121963e-06 9.48575664328734e-05 DOWN ENSG00000162377 COA7 cytochrome c oxidase assembly factor 7 (putative) [Source:HGNC Symbol;Acc:HGNC:25716] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0005758|GO:0005740|GO:0005739 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|mitochondrial intermembrane space|mitochondrial envelope|mitochondrion - - - - 1:52684451-52698366 1395 1761 1248 812 967 552 20.6785258693711 23.723824619558 16.6791575215701 10.7844763464008 11.7608768800427 7.66854883429935 20.3605026701664 10.0713006869143 1.0155231634705 9.41467318564906e-06 9.52764926387685e-05 UP ENSG00000075213 SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A [Source:HGNC Symbol;Acc:HGNC:10723] GO:0040011|GO:0032502|GO:0040007|GO:0045499|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0042995|GO:0048523|GO:0048521|GO:0050794|GO:0040012|GO:0016049|GO:0044702|GO:0050795|GO:0003006|GO:0048870|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0040008|GO:0009605|GO:0005615|GO:0050793|GO:0048589|GO:0005515|GO:0048856|GO:0045137|GO:0051272|GO:0006935|GO:0045595|GO:2000020|GO:0009888|GO:0048468|GO:0007275|GO:0010632|GO:0045596|GO:0048513|GO:0032535|GO:0005102|GO:0016358|GO:0030900|GO:0051128|GO:2000147|GO:0007420|GO:0045597|GO:0048608|GO:0021854|GO:0030308|GO:0007389|GO:0001763|GO:0060322|GO:0021987|GO:0050920|GO:0006928|GO:0009887|GO:0043005|GO:0048729|GO:0007548|GO:0036477|GO:0021988|GO:0060384|GO:0008037|GO:0008406|GO:0007154|GO:0051270|GO:0021772|GO:0016477|GO:0007165|GO:0048588|GO:0048638|GO:0050922|GO:0021675|GO:0008219|GO:0051271|GO:0048532|GO:0021602|GO:0048640|GO:0021543|GO:0030030|GO:0002027|GO:0048869|GO:2000145|GO:0021537|GO:0010633|GO:0001558|GO:2000146|GO:0021536|GO:0048732|GO:0003013|GO:0060560|GO:0050768|GO:0000902|GO:0031175|GO:0022029|GO:0048485|GO:0031344|GO:0090132|GO:0008584|GO:0007166|GO:0002009|GO:0030424|GO:0046661|GO:0061458|GO:0007417|GO:0010720|GO:0048483|GO:0048813|GO:0009880|GO:0010721|GO:0061138|GO:0021761|GO:0022612|GO:0038191|GO:0000904|GO:0050919|GO:0009790|GO:0030334|GO:0001667|GO:0021885|GO:0030517|GO:0048486|GO:0001764|GO:0021979|GO:0031345|GO:0003002|GO:0007431|GO:0060485|GO:0050769|GO:0030425|GO:0008361|GO:0061548|GO:0008038|GO:0022604|GO:0060385|GO:0021855|GO:0035272|GO:0030336|GO:0021872|GO:0021636|GO:0012501|GO:0060429|GO:0021795|GO:0006929|GO:0048864|GO:0030516|GO:0032990|GO:0030215|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0048880|GO:0030335|GO:0021610|GO:0008015|GO:1902667|GO:1990138|GO:0051960|GO:0046546|GO:0021545|GO:0048666|GO:0030182|GO:0008016|GO:0007411|GO:0021637|GO:0021953|GO:0001755|GO:0021800|GO:0048863|GO:1903045|GO:2001222|GO:0010975|GO:0010769|GO:0097491|GO:0048841|GO:0021559|GO:0007413|GO:0060047|GO:0014031|GO:1902285|GO:0061550|GO:0061564|GO:0021828|GO:0097490|GO:0060445|GO:2001224|GO:0021954|GO:1901166|GO:0061549|GO:0010631|GO:0048762|GO:0007435|GO:0021879|GO:0045665|GO:0071526|GO:0022008|GO:0048667|GO:0050767|GO:0048843|GO:0021612|GO:0048812|GO:0010977|GO:0035282|GO:0006915|GO:0050771|GO:0048675|GO:0014033|GO:0014032|GO:0061551|GO:0007409|GO:0008045|GO:0048699|GO:0060666|GO:1902287|GO:0021884|GO:1903375|GO:0048846|GO:0050770|GO:0045664|GO:0036486|GO:0021785 locomotion|developmental process|growth|chemorepellent activity|reproduction|behavior|signaling|cell|cellular process|extracellular region|reproductive process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|cell projection|negative regulation of cellular process|negative regulation of behavior|regulation of cellular process|regulation of locomotion|cell growth|single organism reproductive process|regulation of behavior|developmental process involved in reproduction|cell motility|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|regulation of growth|response to external stimulus|extracellular space|regulation of developmental process|developmental growth|protein binding|anatomical structure development|development of primary sexual characteristics|positive regulation of cellular component movement|chemotaxis|regulation of cell differentiation|positive regulation of male gonad development|tissue development|cell development|multicellular organism development|regulation of epithelial cell migration|negative regulation of cell differentiation|animal organ development|regulation of cellular component size|receptor binding|dendrite development|forebrain development|regulation of cellular component organization|positive regulation of cell motility|brain development|positive regulation of cell differentiation|reproductive structure development|hypothalamus development|negative regulation of cell growth|pattern specification process|morphogenesis of a branching structure|head development|cerebral cortex development|regulation of chemotaxis|movement of cell or subcellular component|organ morphogenesis|neuron projection|tissue morphogenesis|sex differentiation|somatodendritic compartment|olfactory lobe development|innervation|cell recognition|gonad development|cell communication|regulation of cellular component movement|olfactory bulb development|cell migration|signal transduction|developmental cell growth|regulation of developmental growth|negative regulation of chemotaxis|nerve development|cell death|negative regulation of cellular component movement|anatomical structure arrangement|cranial nerve morphogenesis|negative regulation of developmental growth|pallium development|cell projection organization|regulation of heart rate|cellular developmental process|regulation of cell motility|telencephalon development|negative regulation of epithelial cell migration|regulation of cell growth|negative regulation of cell motility|diencephalon development|gland development|circulatory system process|developmental growth involved in morphogenesis|negative regulation of neurogenesis|cell morphogenesis|neuron projection development|telencephalon cell migration|sympathetic nervous system development|regulation of cell projection organization|epithelium migration|male gonad development|cell surface receptor signaling pathway|morphogenesis of an epithelium|axon|male sex differentiation|reproductive system development|central nervous system development|positive regulation of cell development|autonomic nervous system development|dendrite morphogenesis|embryonic pattern specification|negative regulation of cell development|morphogenesis of a branching epithelium|limbic system development|gland morphogenesis|neuropilin binding|cell morphogenesis involved in differentiation|negative chemotaxis|embryo development|regulation of cell migration|ameboidal-type cell migration|forebrain cell migration|negative regulation of axon extension|parasympathetic nervous system development|neuron migration|hypothalamus cell differentiation|negative regulation of cell projection organization|regionalization|salivary gland development|mesenchyme development|positive regulation of neurogenesis|dendrite|regulation of cell size|ganglion development|neuron recognition|regulation of cell morphogenesis|axonogenesis involved in innervation|hypothalamus cell migration|exocrine system development|negative regulation of cell migration|forebrain generation of neurons|trigeminal nerve morphogenesis|programmed cell death|epithelium development|cerebral cortex cell migration|substrate-dependent cell migration|stem cell development|regulation of axon extension|cell part morphogenesis|semaphorin receptor binding|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|sensory system development|positive regulation of cell migration|facial nerve morphogenesis|blood circulation|regulation of axon guidance|neuron projection extension|regulation of nervous system development|development of primary male sexual characteristics|cranial nerve development|neuron development|neuron differentiation|regulation of heart contraction|axon guidance|trigeminal nerve structural organization|central nervous system neuron differentiation|neural crest cell migration|cerebral cortex tangential migration|stem cell differentiation|neural crest cell migration involved in sympathetic nervous system development|regulation of neuron migration|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|sympathetic neuron projection guidance|regulation of axon extension involved in axon guidance|trigeminal nerve development|axonal fasciculation|heart contraction|mesenchymal cell development|semaphorin-plexin signaling pathway involved in neuron projection guidance|cranial ganglion development|axon development|gonadotrophin-releasing hormone neuronal migration to the hypothalamus|sympathetic neuron projection extension|branching involved in salivary gland morphogenesis|positive regulation of neuron migration|central nervous system neuron development|neural crest cell migration involved in autonomic nervous system development|sympathetic ganglion development|epithelial cell migration|mesenchymal cell differentiation|salivary gland morphogenesis|forebrain neuron differentiation|negative regulation of neuron differentiation|semaphorin-plexin signaling pathway|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|negative regulation of axon extension involved in axon guidance|facial nerve structural organization|neuron projection morphogenesis|negative regulation of neuron projection development|segmentation|apoptotic process|negative regulation of axonogenesis|axon extension|neural crest cell differentiation|neural crest cell development|trigeminal ganglion development|axonogenesis|motor neuron axon guidance|generation of neurons|dichotomous subdivision of terminal units involved in salivary gland branching|semaphorin-plexin signaling pathway involved in axon guidance|forebrain neuron development|facioacoustic ganglion development|axon extension involved in axon guidance|regulation of axonogenesis|regulation of neuron differentiation|ventral trunk neural crest cell migration|branchiomotor neuron axon guidance K06840 semaphorin 3[-] hsa04360 Axon guidance - Homo sapiens (human) 7:83955777-84492724 18 35 62 144 144 98 0.12115999562431 0.214110381332696 0.376258990112167 0.868448204807686 0.795270839139108 0.618217646590655 0.237176455689724 0.760645563512483 -1.68126355873887 9.44374010154835e-06 9.55382639754742e-05 DOWN ENSG00000147408 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:24290] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0008283|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0044262|GO:0031228|GO:0006725|GO:0009888|GO:1901360|GO:0006082|GO:0007275|GO:0048513|GO:0034641|GO:0043062|GO:0044281|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0009887|GO:0008037|GO:0006139|GO:0001503|GO:0016757|GO:0060348|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0005794|GO:0006790|GO:0048705|GO:0005976|GO:0034645|GO:0051216|GO:0046872|GO:0009225|GO:0015012|GO:0008194|GO:0030204|GO:0030173|GO:0009100|GO:0006040|GO:0016758|GO:0033692|GO:0030201|GO:0005795|GO:1901137|GO:0007399|GO:0060349|GO:0000139|GO:0030198|GO:0009059|GO:0001501|GO:0061448|GO:0016051|GO:0009101|GO:0030210|GO:0019276|GO:0060350|GO:0000271|GO:0030206|GO:0046398|GO:0031985|GO:0015020|GO:0050650|GO:0015014|GO:0032580|GO:0006024|GO:0006029|GO:0001958|GO:0019752|GO:0050653|GO:0030203|GO:0008376|GO:0008955|GO:0050655|GO:0047238|GO:0047237|GO:0030166|GO:0050651 developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|cell proliferation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|anatomical structure development|organelle membrane|cellular carbohydrate metabolic process|intrinsic component of Golgi membrane|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|extracellular structure organization|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|organ morphogenesis|cell recognition|nucleobase-containing compound metabolic process|ossification|transferase activity, transferring glycosyl groups|bone development|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|Golgi apparatus|sulfur compound metabolic process|skeletal system morphogenesis|polysaccharide metabolic process|cellular macromolecule biosynthetic process|cartilage development|metal ion binding|nucleotide-sugar metabolic process|heparan sulfate proteoglycan biosynthetic process|UDP-glycosyltransferase activity|chondroitin sulfate metabolic process|integral component of Golgi membrane|glycoprotein metabolic process|amino sugar metabolic process|transferase activity, transferring hexosyl groups|cellular polysaccharide biosynthetic process|heparan sulfate proteoglycan metabolic process|Golgi stack|carbohydrate derivative biosynthetic process|nervous system development|bone morphogenesis|Golgi membrane|extracellular matrix organization|macromolecule biosynthetic process|skeletal system development|connective tissue development|carbohydrate biosynthetic process|glycoprotein biosynthetic process|heparin biosynthetic process|UDP-N-acetylgalactosamine metabolic process|endochondral bone morphogenesis|polysaccharide biosynthetic process|chondroitin sulfate biosynthetic process|UDP-glucuronate metabolic process|Golgi cisterna|glucuronosyltransferase activity|chondroitin sulfate proteoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|Golgi cisterna membrane|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|endochondral ossification|carboxylic acid metabolic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|glycosaminoglycan metabolic process|acetylgalactosaminyltransferase activity|peptidoglycan glycosyltransferase activity|dermatan sulfate proteoglycan metabolic process|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process K00746 chondroitin sulfate N-acetylgalactosaminyltransferase 1/2[2.4.1.175] hsa01100|hsa00532 Metabolic pathways - Homo sapiens (human)|Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human) 8:19404161-19758029 121 262 301 541 555 651 0.798804648893682 1.5719340312381 1.79157191211925 3.19998647441668 3.00617828342702 4.02776015218623 1.38743686408368 3.41130830334331 -1.29790302460294 9.49157833526347e-06 9.59247053557737e-05 DOWN ENSG00000165322 ARHGAP12 Rho GTPase activating protein 12 [Source:HGNC Symbol;Acc:HGNC:16348] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0009653|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0009888|GO:0008047|GO:0005737|GO:0009966|GO:0048729|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005829|GO:0005096|GO:0002009|GO:0051345|GO:0030695|GO:0060429|GO:0035556|GO:1902531|GO:0002011|GO:0043087|GO:0043547|GO:0051056|GO:0007264 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|anatomical structure morphogenesis|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|anatomical structure development|regulation of metabolic process|tissue development|enzyme activator activity|cytoplasm|regulation of signal transduction|tissue morphogenesis|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cytosol|GTPase activator activity|morphogenesis of an epithelium|positive regulation of hydrolase activity|GTPase regulator activity|epithelium development|intracellular signal transduction|regulation of intracellular signal transduction|morphogenesis of an epithelial sheet|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 10:31805404-31928876 362 386 657 905 1029 1117 1.54192463926753 1.49424697126733 2.52309741759524 3.45382766325754 3.59614953365281 4.45899234045668 1.85308967604337 3.83632317912234 -1.04979156184846 9.49637445616713e-06 9.59406981436256e-05 DOWN ENSG00000173214 KIAA1919 KIAA1919 [Source:HGNC Symbol;Acc:HGNC:21053] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0045177|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0016324|GO:0055085|GO:0016021|GO:0006811|GO:0008643|GO:0015293|GO:0006812|GO:0030001|GO:0015672|GO:0006814 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|apical part of cell|cell periphery|intrinsic component of membrane|plasma membrane|transport|apical plasma membrane|transmembrane transport|integral component of membrane|ion transport|carbohydrate transport|symporter activity|cation transport|metal ion transport|monovalent inorganic cation transport|sodium ion transport - - - - 6:111259348-111271167 61 67 111 195 211 202 0.724232838730985 0.722940527686392 1.18818343416429 2.07432854816289 2.05539643799017 2.2476356106594 0.878452266860556 2.12578686560415 -1.27496115683468 9.49992469581592e-06 9.59440973846037e-05 DOWN ENSG00000152763 WDR78 WD repeat domain 78 [Source:HGNC Symbol;Acc:HGNC:26252] GO:0032502|GO:0002376|GO:0009987|GO:0005488|GO:0002520|GO:0005515|GO:0048856|GO:0007275|GO:0048513|GO:0048869|GO:0030097|GO:0030154|GO:0002244 developmental process|immune system process|cellular process|binding|immune system development|protein binding|anatomical structure development|multicellular organism development|animal organ development|cellular developmental process|hemopoiesis|cell differentiation|hematopoietic progenitor cell differentiation - - - - 1:66812885-66924887 38 52 64 140 133 129 0.261453935796913 0.325157057495537 0.397010196584203 0.863048222341857 0.750811822957852 0.83181781003615 0.327873729958884 0.81522595177862 -1.3140596646446 9.56329303215418e-06 9.65514204199969e-05 DOWN ENSG00000085982 USP40 ubiquitin specific peptidase 40 [Source:HGNC Symbol;Acc:HGNC:20069] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0043231|GO:0008233|GO:0005737|GO:0019538|GO:0036459|GO:0043412|GO:0030163|GO:0044265|GO:0036211|GO:0006508|GO:0044267|GO:0005634|GO:0044257|GO:0051603|GO:0070646|GO:0008234|GO:0006464|GO:0019941|GO:0016579|GO:0006511 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|protein metabolic process|thiol-dependent ubiquitinyl hydrolase activity|macromolecule modification|protein catabolic process|cellular macromolecule catabolic process|protein modification process|proteolysis|cellular protein metabolic process|nucleus|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|protein modification by small protein removal|cysteine-type peptidase activity|cellular protein modification process|modification-dependent protein catabolic process|protein deubiquitination|ubiquitin-dependent protein catabolic process - - - - 2:233475520-233566782 1134 770 1094 2133 2339 2112 6.06040880903275 3.73989751059227 5.27133474454923 10.2135671017088 10.2562181172617 10.5781998268805 5.02388035472475 10.349328348617 -1.0426631311266 9.5845350172019e-06 9.6733167141158e-05 DOWN ENSG00000151687 ANKAR ankyrin and armadillo repeat containing [Source:HGNC Symbol;Acc:HGNC:26350] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 2:189674290-189761193 9 4 10 30 34 36 0.0787427578241106 0.0318057153143201 0.0788844180540674 0.235171485466048 0.244066532793319 0.29518477434749 0.063144297064166 0.258140930868952 -2.03143456686856 9.6489364410942e-06 9.73173474704142e-05 DOWN ENSG00000256616 RP11-815J4.6 - - - - - - - 18:12073232-12076654 1 0 1 8 13 9 0.0146971325903663 0 0.0132387700560425 0.105305674113121 0.156692259709861 0.123913234714406 0.00931196754880293 0.128637056179129 -3.78807645551474 9.65699858467245e-06 9.73657668851102e-05 DOWN ENSG00000174365 SNHG11 small nucleolar RNA host gene 11 [Source:HGNC Symbol;Acc:HGNC:25046] - - - - - - 20:38446578-38450921 253 251 164 79 93 115 1.98276309414436 1.78774022230272 1.15880052448993 0.554722696699516 0.598000810036278 0.844654105134412 1.64310128031234 0.665792537290069 1.30327680549909 9.71956651828169e-06 9.79635175006014e-05 UP ENSG00000160200 CBS cystathionine-beta-synthase [Source:HGNC Symbol;Acc:HGNC:1550] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0072341|GO:0043227|GO:0048037|GO:0019825|GO:0009605|GO:0009058|GO:0005622|GO:0070026|GO:0005515|GO:0042802|GO:0006575|GO:0006725|GO:1901360|GO:0006082|GO:0009991|GO:0034641|GO:0043168|GO:0044281|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0006520|GO:0031668|GO:0046983|GO:0006139|GO:0007154|GO:1904047|GO:0030170|GO:0042262|GO:0044249|GO:0006790|GO:0055114|GO:0005829|GO:0046872|GO:0020037|GO:0070025|GO:0070813|GO:0000096|GO:0016836|GO:0009063|GO:0050667|GO:0008652|GO:0006259|GO:0004124|GO:0042219|GO:0005634|GO:0042803|GO:0044389|GO:0031625|GO:0043418|GO:0070814|GO:0046395|GO:0006534|GO:0019752|GO:0004122|GO:0000098|GO:0009069|GO:0019346|GO:0050421|GO:0000097|GO:0006563|GO:0046439|GO:0019344|GO:0009071|GO:0009070|GO:0006565|GO:0019343|GO:0006535|GO:0019448 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|modified amino acid binding|membrane-bounded organelle|cofactor binding|oxygen binding|response to external stimulus|biosynthetic process|intracellular|nitric oxide binding|protein binding|identical protein binding|cellular modified amino acid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|response to extracellular stimulus|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|cellular amino acid metabolic process|cellular response to extracellular stimulus|protein dimerization activity|nucleobase-containing compound metabolic process|cell communication|S-adenosyl-L-methionine binding|pyridoxal phosphate binding|DNA protection|cellular biosynthetic process|sulfur compound metabolic process|oxidation-reduction process|cytosol|metal ion binding|heme binding|carbon monoxide binding|hydrogen sulfide metabolic process|sulfur amino acid metabolic process|hydro-lyase activity|cellular amino acid catabolic process|homocysteine metabolic process|cellular amino acid biosynthetic process|DNA metabolic process|cysteine synthase activity|cellular modified amino acid catabolic process|nucleus|protein homodimerization activity|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|homocysteine catabolic process|hydrogen sulfide biosynthetic process|carboxylic acid catabolic process|cysteine metabolic process|carboxylic acid metabolic process|cystathionine beta-synthase activity|sulfur amino acid catabolic process|serine family amino acid metabolic process|transsulfuration|nitrite reductase (NO-forming) activity|sulfur amino acid biosynthetic process|L-serine metabolic process|L-cysteine metabolic process|cysteine biosynthetic process|serine family amino acid catabolic process|serine family amino acid biosynthetic process|L-serine catabolic process|cysteine biosynthetic process via cystathionine|cysteine biosynthetic process from serine|L-cysteine catabolic process K01697 cystathionine beta-synthase[4.2.1.22] hsa01100|hsa01230|hsa00270|hsa00260 Metabolic pathways - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Cysteine and methionine metabolism - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human) 21:43053191-43076943 18 29 44 90 100 82 0.124830430785869 0.182780606367734 0.275114464657025 0.559223958821469 0.569002307885403 0.532954538085971 0.194241833936876 0.553726934930948 -1.51132075257322 9.79227722215724e-06 9.86297719940223e-05 DOWN ENSG00000168765 GSTM4 glutathione S-transferase mu 4 [Source:HGNC Symbol;Acc:HGNC:4636] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0033218|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0072341|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0042802|GO:0006575|GO:0042277|GO:0006725|GO:1901360|GO:0009410|GO:0034641|GO:0043168|GO:0044281|GO:0019899|GO:0005737|GO:0046983|GO:0016765|GO:0006805|GO:0018916|GO:0044249|GO:0043295|GO:0006790|GO:0005829|GO:0006518|GO:0004364|GO:0071466|GO:0006749|GO:0043603|GO:1901687|GO:0042178|GO:0042803 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|amide binding|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|modified amino acid binding|biosynthetic process|intracellular|protein binding|transferase activity|identical protein binding|cellular modified amino acid metabolic process|peptide binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|response to xenobiotic stimulus|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|enzyme binding|cytoplasm|protein dimerization activity|transferase activity, transferring alkyl or aryl (other than methyl) groups|xenobiotic metabolic process|nitrobenzene metabolic process|cellular biosynthetic process|glutathione binding|sulfur compound metabolic process|cytosol|peptide metabolic process|glutathione transferase activity|cellular response to xenobiotic stimulus|glutathione metabolic process|cellular amide metabolic process|glutathione derivative biosynthetic process|xenobiotic catabolic process|protein homodimerization activity K00799 glutathione S-transferase[2.5.1.18] hsa05204|hsa00980|hsa00982|hsa00480 Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Glutathione metabolism - Homo sapiens (human) 1:109656081-109674836 166 210 279 504 459 498 1.18250770765222 1.35955019502564 1.79190761760159 3.21680359559314 2.68273045660916 3.32471920305915 1.44465517342648 3.07475108508715 -1.08974444742445 9.87415833637888e-06 9.93874318861278e-05 DOWN ENSG00000188315 C3orf62 chromosome 3 open reading frame 62 [Source:HGNC Symbol;Acc:HGNC:24771] GO:0005488|GO:0005515 binding|protein binding - - - - 3:49268602-49277909 237 189 263 131 100 100 1.95756847496817 1.41876815945843 1.95857003863105 0.969477248895509 0.677700086458561 0.774103309058458 1.77830222435255 0.807093548137509 1.13969272518079 1.00038447639631e-05 0.000100624926409486 UP ENSG00000205189 ZBTB10 zinc finger and BTB domain containing 10 [Source:HGNC Symbol;Acc:HGNC:30953] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 8:80485619-80526265 61 70 164 230 300 413 0.181782839160771 0.189582135296578 0.440634180142649 0.614108065630687 0.733516056000899 1.15345107476797 0.270666384866666 0.833691732133185 -1.62299830322028 1.0062477657224e-05 0.000101180602215819 DOWN ENSG00000168216 LMBRD1 LMBR1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:23038] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0051051|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0023057|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0031090|GO:0016032|GO:0006725|GO:0006810|GO:0031623|GO:1901360|GO:0005102|GO:0044281|GO:0031982|GO:0046483|GO:1900076|GO:0043231|GO:0010243|GO:0005774|GO:0005737|GO:0032403|GO:0009966|GO:0019842|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0009235|GO:0010829|GO:0016021|GO:0010033|GO:0016192|GO:0007166|GO:0031410|GO:0031419|GO:1901652|GO:0005773|GO:0071417|GO:0038016|GO:0016023|GO:0005158|GO:0043434|GO:0031988|GO:0035556|GO:0071310|GO:1902532|GO:0046627|GO:0046626|GO:1902531|GO:0008643|GO:0046325|GO:0032870|GO:0010827|GO:0006766|GO:0043112|GO:0051896|GO:0043491|GO:0051898|GO:0030139|GO:1901653|GO:0000323|GO:0046324|GO:0007167|GO:0030135|GO:0071375|GO:0032868|GO:0006897|GO:0006767|GO:0005765|GO:0030136|GO:0008645|GO:0005764|GO:0032869|GO:0006898|GO:0045334|GO:0007169|GO:0015758|GO:0008286|GO:0046323 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|negative regulation of transport|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|negative regulation of signaling|intrinsic component of membrane|intracellular|protein binding|plasma membrane|organelle membrane|viral process|cellular aromatic compound metabolic process|transport|receptor internalization|organic cyclic compound metabolic process|receptor binding|small molecule metabolic process|vesicle|heterocycle metabolic process|regulation of cellular response to insulin stimulus|intracellular membrane-bounded organelle|response to organonitrogen compound|vacuolar membrane|cytoplasm|protein complex binding|regulation of signal transduction|vitamin binding|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|cobalamin metabolic process|negative regulation of glucose transport|integral component of membrane|response to organic substance|vesicle-mediated transport|cell surface receptor signaling pathway|cytoplasmic vesicle|cobalamin binding|response to peptide|vacuole|cellular response to organonitrogen compound|insulin receptor internalization|cytoplasmic, membrane-bounded vesicle|insulin receptor binding|response to peptide hormone|membrane-bounded vesicle|intracellular signal transduction|cellular response to organic substance|negative regulation of intracellular signal transduction|negative regulation of insulin receptor signaling pathway|regulation of insulin receptor signaling pathway|regulation of intracellular signal transduction|carbohydrate transport|negative regulation of glucose import|cellular response to hormone stimulus|regulation of glucose transport|vitamin metabolic process|receptor metabolic process|regulation of protein kinase B signaling|protein kinase B signaling|negative regulation of protein kinase B signaling|endocytic vesicle|cellular response to peptide|lytic vacuole|regulation of glucose import|enzyme linked receptor protein signaling pathway|coated vesicle|cellular response to peptide hormone stimulus|response to insulin|endocytosis|water-soluble vitamin metabolic process|lysosomal membrane|clathrin-coated vesicle|hexose transport|lysosome|cellular response to insulin stimulus|receptor-mediated endocytosis|clathrin-coated endocytic vesicle|transmembrane receptor protein tyrosine kinase signaling pathway|glucose transport|insulin receptor signaling pathway|glucose import K14617 LMBR1 domain-containing protein 1[-] hsa04977 Vitamin digestion and absorption - Homo sapiens (human) 6:69675802-69797111 175 214 366 594 529 691 3.46651826771059 3.85255744747154 6.53659095368622 10.5424094327132 8.59764652046084 12.8281244552047 4.61855555628945 10.6560601361262 -1.20616050181055 1.01514961647698e-05 0.000102006989735118 DOWN ENSG00000185305 ARL15 ADP ribosylation factor like GTPase 15 [Source:HGNC Symbol;Acc:HGNC:25945] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0012505|GO:0006810|GO:0043168|GO:0001882|GO:0031982|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0070062|GO:0000166|GO:0005794|GO:0035639|GO:0001883|GO:0015031|GO:0032549|GO:0035556|GO:0017076|GO:0032561|GO:0005525|GO:0007264|GO:0019001 signaling|cell|cellular process|extracellular region|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|endomembrane system|transport|anion binding|nucleoside binding|vesicle|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|extracellular exosome|nucleotide binding|Golgi apparatus|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding - - - - 5:53883945-54310582 22 22 47 100 82 100 0.183601303186471 0.166861803414291 0.353641850084347 0.747745741628992 0.561485419384643 0.782140247614043 0.23470165222837 0.697123802875893 -1.57058689039241 1.02269925083978e-05 0.000102731034436644 DOWN ENSG00000272990 RP11-305K5.1 - - - - - - - 3:156523740-156524247 16 14 22 4 4 3 2.22795918921169 1.77169730139168 2.76191022750779 0.49906183154988 0.456961944172329 0.391451252230619 2.25385557270372 0.449158342650943 2.32709903463115 1.02986922655723e-05 0.000103416467842716 UP ENSG00000147684 NDUFB9 NADH:ubiquinone oxidoreductase subunit B9 [Source:HGNC Symbol;Acc:HGNC:7704] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0016043|GO:0070469|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0006725|GO:0019866|GO:1901360|GO:0005746|GO:0050877|GO:0034641|GO:0015980|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0031966|GO:0006139|GO:0016651|GO:0055086|GO:0045271|GO:0000422|GO:0070062|GO:0016236|GO:0006091|GO:0022900|GO:0006996|GO:0055114|GO:0005740|GO:1903008|GO:0000423|GO:0019693|GO:0007005|GO:0005747|GO:0009116|GO:0022904|GO:0007600|GO:0005743|GO:0005739|GO:0016655|GO:0006796|GO:0006119|GO:0045333|GO:0003954|GO:0050954|GO:0009259|GO:0009117|GO:0042773|GO:0016310|GO:0006163|GO:0098779|GO:0006120|GO:0042278|GO:0007605|GO:0042775|GO:0008137|GO:0046034 macromolecular complex|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|cellular component organization|respiratory chain|membrane-bounded organelle|intracellular|protein binding|protein complex|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|organic cyclic compound metabolic process|mitochondrial respiratory chain|neurological system process|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|nucleobase-containing compound metabolic process|oxidoreductase activity, acting on NAD(P)H|nucleobase-containing small molecule metabolic process|respiratory chain complex I|mitophagy|extracellular exosome|macroautophagy|generation of precursor metabolites and energy|electron transport chain|organelle organization|oxidation-reduction process|mitochondrial envelope|organelle disassembly|macromitophagy|ribose phosphate metabolic process|mitochondrion organization|mitochondrial respiratory chain complex I|nucleoside metabolic process|respiratory electron transport chain|sensory perception|mitochondrial inner membrane|mitochondrion|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phosphate-containing compound metabolic process|oxidative phosphorylation|cellular respiration|NADH dehydrogenase activity|sensory perception of mechanical stimulus|ribonucleotide metabolic process|nucleotide metabolic process|ATP synthesis coupled electron transport|phosphorylation|purine nucleotide metabolic process|mitophagy in response to mitochondrial depolarization|mitochondrial electron transport, NADH to ubiquinone|purine nucleoside metabolic process|sensory perception of sound|mitochondrial ATP synthesis coupled electron transport|NADH dehydrogenase (ubiquinone) activity|ATP metabolic process K03965 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9[-] hsa01100|hsa05016|hsa05010|hsa04932|hsa05012|hsa00190 Metabolic pathways - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Parkinson,s disease - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human) 8:124539103-124568510 3440 3547 2573 1950 1523 786 61.8071595539622 57.9190587493981 41.6806424351236 31.3915404875653 22.4516408140004 13.2352435673543 53.802286912828 22.3594749563067 1.26678118577759 1.03920992112271e-05 0.000104250680247066 UP ENSG00000169860 P2RY1 purinergic receptor P2Y, G-protein coupled, 1 [Source:HGNC Symbol;Acc:HGNC:8539] GO:0040011|GO:0032502|GO:0004871|GO:0000003|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0042995|GO:0007631|GO:0097159|GO:0004872|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0009986|GO:0019953|GO:0051051|GO:0044237|GO:0051641|GO:0045177|GO:0038023|GO:0048870|GO:0023051|GO:0044297|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0048609|GO:0019222|GO:0060341|GO:0060405|GO:0044262|GO:0007618|GO:0050817|GO:0043084|GO:0006725|GO:0046887|GO:0016323|GO:0006810|GO:0009612|GO:1901360|GO:0016324|GO:0007275|GO:0043647|GO:0050877|GO:0005102|GO:0034641|GO:0043168|GO:0044281|GO:0032940|GO:0001882|GO:0043270|GO:0019637|GO:0031325|GO:0046483|GO:0045211|GO:0051098|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0003012|GO:0007267|GO:0009611|GO:0005975|GO:0006928|GO:0042592|GO:0097110|GO:0001775|GO:0043005|GO:0009966|GO:0046983|GO:0060406|GO:0046883|GO:0019725|GO:0036477|GO:0097481|GO:0014069|GO:0010646|GO:0006139|GO:0031226|GO:0008104|GO:0007154|GO:0044092|GO:0061024|GO:0016477|GO:0007165|GO:0051047|GO:0051048|GO:1903531|GO:0000166|GO:0010817|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0042755|GO:0010469|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0010256|GO:0050878|GO:0003013|GO:0007568|GO:0000165|GO:1902533|GO:0032268|GO:0006109|GO:0005829|GO:0007186|GO:0035150|GO:0010468|GO:0034645|GO:0030168|GO:0007166|GO:0051100|GO:0035639|GO:0043412|GO:0050432|GO:0015844|GO:0046982|GO:0048878|GO:0007596|GO:0051252|GO:0006066|GO:0001883|GO:0010628|GO:0007009|GO:0032957|GO:0036211|GO:0042060|GO:0006811|GO:0032549|GO:0055082|GO:0043531|GO:0007600|GO:0051046|GO:0072657|GO:0023019|GO:0007599|GO:0030425|GO:0009914|GO:0033604|GO:0051247|GO:0070848|GO:0001664|GO:0005739|GO:0032958|GO:0007620|GO:0043269|GO:0034613|GO:0032270|GO:0014070|GO:0006796|GO:0035556|GO:0090075|GO:0044267|GO:0051174|GO:0010467|GO:0007399|GO:0046903|GO:0071310|GO:0017076|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:1902531|GO:0016070|GO:0008015|GO:0004930|GO:0010557|GO:0016051|GO:0015837|GO:0008347|GO:0060732|GO:0045893|GO:0007200|GO:0031401|GO:0007187|GO:0032959|GO:0042312|GO:0019233|GO:0001609|GO:0043408|GO:0072659|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0016310|GO:0001614|GO:0070371|GO:0071407|GO:0043410|GO:0031685|GO:0050801|GO:0022008|GO:0006464|GO:1990778|GO:0046879|GO:0048243|GO:0006351|GO:0006355|GO:0006873|GO:0050880|GO:0010700|GO:0035590|GO:0031686|GO:0045944|GO:0006366|GO:0007188|GO:0006357|GO:0035589|GO:0032960|GO:0006468|GO:1903506|GO:0042311|GO:0042325|GO:0032962|GO:0070374|GO:0001932|GO:0042063|GO:0001934|GO:0045031|GO:0045032|GO:0014061|GO:0045028|GO:0001973|GO:0070372|GO:0015874|GO:0030003|GO:0042327|GO:0007193|GO:0055065|GO:0006875|GO:0006874|GO:0055074|GO:0051480|GO:0007204 locomotion|developmental process|signal transducer activity|reproduction|synapse|behavior|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|cell projection|feeding behavior|organic cyclic compound binding|receptor activity|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|cell surface|sexual reproduction|negative regulation of transport|cellular metabolic process|cellular localization|apical part of cell|signaling receptor activity|cell motility|regulation of signaling|cell body|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|synaptic membrane|multicellular organismal reproductive process|regulation of metabolic process|regulation of cellular localization|regulation of penile erection|cellular carbohydrate metabolic process|mating|coagulation|penile erection|cellular aromatic compound metabolic process|positive regulation of hormone secretion|basolateral plasma membrane|transport|response to mechanical stimulus|organic cyclic compound metabolic process|apical plasma membrane|multicellular organism development|inositol phosphate metabolic process|neurological system process|receptor binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|secretion by cell|nucleoside binding|positive regulation of ion transport|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|postsynaptic membrane|regulation of binding|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|muscle system process|cell-cell signaling|response to wounding|carbohydrate metabolic process|movement of cell or subcellular component|homeostatic process|scaffold protein binding|cell activation|neuron projection|regulation of signal transduction|protein dimerization activity|positive regulation of penile erection|regulation of hormone secretion|cellular homeostasis|somatodendritic compartment|neuronal postsynaptic density|postsynaptic density|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|protein localization|cell communication|negative regulation of molecular function|membrane organization|cell migration|signal transduction|positive regulation of secretion|negative regulation of secretion|negative regulation of secretion by cell|nucleotide binding|regulation of hormone levels|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|eating behavior|regulation of receptor activity|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|endomembrane system organization|regulation of body fluid levels|circulatory system process|aging|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|cytosol|G-protein coupled receptor signaling pathway|regulation of tube size|regulation of gene expression|cellular macromolecule biosynthetic process|platelet activation|cell surface receptor signaling pathway|negative regulation of binding|purine ribonucleoside triphosphate binding|macromolecule modification|catecholamine secretion|monoamine transport|protein heterodimerization activity|chemical homeostasis|blood coagulation|regulation of RNA metabolic process|alcohol metabolic process|purine nucleoside binding|positive regulation of gene expression|plasma membrane organization|inositol trisphosphate metabolic process|protein modification process|wound healing|ion transport|ribonucleoside binding|cellular chemical homeostasis|ADP binding|sensory perception|regulation of secretion|protein localization to membrane|signal transduction involved in regulation of gene expression|hemostasis|dendrite|hormone transport|negative regulation of catecholamine secretion|positive regulation of protein metabolic process|response to growth factor|G-protein coupled receptor binding|mitochondrion|inositol phosphate biosynthetic process|copulation|regulation of ion transport|cellular protein localization|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|relaxation of muscle|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|nervous system development|secretion|cellular response to organic substance|purine nucleotide binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|regulation of intracellular signal transduction|RNA metabolic process|blood circulation|G-protein coupled receptor activity|positive regulation of macromolecule biosynthetic process|carbohydrate biosynthetic process|amine transport|glial cell migration|positive regulation of inositol phosphate biosynthetic process|positive regulation of transcription, DNA-templated|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of protein modification process|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|inositol trisphosphate biosynthetic process|regulation of vasodilation|sensory perception of pain|G-protein coupled adenosine receptor activity|regulation of MAPK cascade|protein localization to plasma membrane|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|purinergic nucleotide receptor activity|ERK1 and ERK2 cascade|cellular response to organic cyclic compound|positive regulation of MAPK cascade|adenosine receptor binding|ion homeostasis|neurogenesis|cellular protein modification process|protein localization to cell periphery|hormone secretion|norepinephrine secretion|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of blood vessel size|negative regulation of norepinephrine secretion|purinergic nucleotide receptor signaling pathway|A1 adenosine receptor binding|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|G-protein coupled purinergic nucleotide receptor signaling pathway|regulation of inositol trisphosphate biosynthetic process|protein phosphorylation|regulation of nucleic acid-templated transcription|vasodilation|regulation of phosphorylation|positive regulation of inositol trisphosphate biosynthetic process|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|gliogenesis|positive regulation of protein phosphorylation|ATP-activated adenosine receptor activity|ADP-activated adenosine receptor activity|regulation of norepinephrine secretion|G-protein coupled purinergic nucleotide receptor activity|adenosine receptor signaling pathway|regulation of ERK1 and ERK2 cascade|norepinephrine transport|cellular cation homeostasis|positive regulation of phosphorylation|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04270 purinergic receptor P2Y, G protein-coupled, 1[-] hsa04080|hsa04015|hsa04611|hsa04742 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Taste transduction - Homo sapiens (human) 3:152834693-152841439 82 115 138 37 54 55 0.859703157780514 1.09575665684762 1.30445693352383 0.347561192994637 0.464514228328082 0.540408936753654 1.08663891605065 0.450828119358791 1.26922321243027 1.03922430634176e-05 0.000104250680247066 UP ENSG00000231822 AC019097.7 - - - - - - - 2:99102018-99102752 188 191 140 94 71 54 18.0932056908777 16.705993362939 12.1479279380662 8.1055888304848 5.60637741043822 4.87054877673359 15.6490423306276 6.1941716725522 1.33709109849343 1.03909622076434e-05 0.000104250680247066 UP ENSG00000261996 CTC-281F24.1 - - - - - - - 17:6653464-6655009 15 25 28 65 63 88 1.20709507929115 1.82845617364574 2.03153436581825 4.6866838724848 4.15974295949147 6.63691781654518 1.68902853958505 5.16111488284048 -1.61148903874817 1.04010553408964e-05 0.000104269008108503 DOWN ENSG00000174482 LINGO2 leucine rich repeat and Ig domain containing 2 [Source:HGNC Symbol;Acc:HGNC:21207] GO:0032502|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0044089|GO:0016043|GO:0031224|GO:0050793|GO:0005515|GO:0048856|GO:0051130|GO:0007275|GO:0051128|GO:0022607|GO:0050803|GO:0051963|GO:0051965|GO:0050808|GO:0016021|GO:0007416|GO:0050807|GO:0007399|GO:0051960 developmental process|membrane|cellular process|binding|regulation of cellular process|positive regulation of cellular component biogenesis|cellular component organization|intrinsic component of membrane|regulation of developmental process|protein binding|anatomical structure development|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component organization|cellular component assembly|regulation of synapse structure or activity|regulation of synapse assembly|positive regulation of synapse assembly|synapse organization|integral component of membrane|synapse assembly|regulation of synapse organization|nervous system development|regulation of nervous system development - - - - 9:27948078-28670286 0 2 5 13 16 23 0 0.01394518483277 0.0345831763347829 0.0893621501933654 0.100716354870619 0.165377840991185 0.0161761203891843 0.118485448685056 -2.87277234657789 1.06521862593486e-05 0.000106679090434952 DOWN ENSG00000087338 GMCL1 germ cell-less, spermatogenesis associated 1 [Source:HGNC Symbol;Acc:HGNC:23843] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0043227|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0048609|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0043231|GO:0005635|GO:0006139|GO:0007276|GO:0048869|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0048232|GO:0051252|GO:0031981|GO:0016363|GO:0010467|GO:0009059|GO:0030154|GO:0034399|GO:0016070|GO:0005634|GO:0007283|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|endomembrane system|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nuclear envelope|nucleobase-containing compound metabolic process|gamete generation|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|male gamete generation|regulation of RNA metabolic process|nuclear lumen|nuclear matrix|gene expression|macromolecule biosynthetic process|cell differentiation|nuclear periphery|RNA metabolic process|nucleus|spermatogenesis|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 2:69829642-69881396 413 441 775 1048 1286 1189 5.06489595129067 4.91517521524402 8.56912078789096 11.5154107826874 12.9398598207643 13.6656767682322 6.18306398480855 12.706982457228 -1.03922763207607 1.09643223965713e-05 0.000109621192507448 DOWN ENSG00000232748 RP11-196G11.6 - - - - - - - 16:31056460-31062803 36 76 43 2 19 14 0.381962020103755 0.732838601771303 0.411332850356693 0.0190133051167946 0.16540218288754 0.139214259605348 0.508711157410584 0.107876582536561 2.23746501302585 1.10945847687998e-05 0.000110886419045112 UP ENSG00000198382 UVRAG UV radiation resistance associated [Source:HGNC Symbol;Acc:HGNC:12640] GO:0040011|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0030496|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0019222|GO:0016032|GO:0051726|GO:0007049|GO:0006281|GO:0010506|GO:0006725|GO:0051640|GO:0006810|GO:0022402|GO:1901360|GO:0060627|GO:0051302|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0043231|GO:0051651|GO:0005737|GO:0010508|GO:0019904|GO:0000149|GO:0006139|GO:0061024|GO:0005783|GO:0051649|GO:0050790|GO:0007059|GO:0051301|GO:0007017|GO:0019538|GO:0031323|GO:0005768|GO:0006996|GO:0051701|GO:0061025|GO:0016192|GO:0031023|GO:0032268|GO:0005813|GO:0032801|GO:0016050|GO:0043412|GO:0007010|GO:0031410|GO:0005769|GO:0051645|GO:0017124|GO:0005815|GO:0005773|GO:0006302|GO:0016023|GO:0036211|GO:0046907|GO:0032465|GO:0005770|GO:1990234|GO:0010564|GO:0070418|GO:0031988|GO:0006259|GO:0007051|GO:0005694|GO:0051684|GO:0006461|GO:0006796|GO:0044267|GO:0051174|GO:0019058|GO:0051246|GO:0000226|GO:0005856|GO:0000910|GO:0005634|GO:0006974|GO:0048284|GO:0043112|GO:0006303|GO:0034622|GO:0030139|GO:0000323|GO:0046718|GO:0043623|GO:0016310|GO:0048193|GO:0006906|GO:0015630|GO:0051297|GO:0030260|GO:0006464|GO:0043549|GO:0000775|GO:0045859|GO:1902911|GO:0005764|GO:0006468|GO:0045335|GO:0042325|GO:0001932|GO:0006890|GO:0035493|GO:0097680|GO:1902554|GO:0071900 locomotion|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|midbody|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|protein complex|endomembrane system|regulation of metabolic process|viral process|regulation of cell cycle|cell cycle|DNA repair|regulation of autophagy|cellular aromatic compound metabolic process|organelle localization|transport|cell cycle process|organic cyclic compound metabolic process|regulation of vesicle-mediated transport|regulation of cell division|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|maintenance of location in cell|cytoplasm|positive regulation of autophagy|protein domain specific binding|SNARE binding|nucleobase-containing compound metabolic process|membrane organization|endoplasmic reticulum|establishment of localization in cell|regulation of catalytic activity|chromosome segregation|cell division|microtubule-based process|protein metabolic process|regulation of cellular metabolic process|endosome|organelle organization|interaction with host|membrane fusion|vesicle-mediated transport|microtubule organizing center organization|regulation of cellular protein metabolic process|centrosome|receptor catabolic process|vesicle organization|macromolecule modification|cytoskeleton organization|cytoplasmic vesicle|early endosome|Golgi localization|SH3 domain binding|microtubule organizing center|vacuole|double-strand break repair|cytoplasmic, membrane-bounded vesicle|protein modification process|intracellular transport|regulation of cytokinesis|late endosome|transferase complex|regulation of cell cycle process|DNA-dependent protein kinase complex|membrane-bounded vesicle|DNA metabolic process|spindle organization|chromosome|maintenance of Golgi location|protein complex assembly|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|viral life cycle|regulation of protein metabolic process|microtubule cytoskeleton organization|cytoskeleton|cytokinesis|nucleus|cellular response to DNA damage stimulus|organelle fusion|receptor metabolic process|double-strand break repair via nonhomologous end joining|cellular macromolecular complex assembly|endocytic vesicle|lytic vacuole|viral entry into host cell|cellular protein complex assembly|phosphorylation|Golgi vesicle transport|vesicle fusion|microtubule cytoskeleton|centrosome organization|entry into host cell|cellular protein modification process|regulation of kinase activity|chromosome, centromeric region|regulation of protein kinase activity|protein kinase complex|lysosome|protein phosphorylation|phagocytic vesicle|regulation of phosphorylation|regulation of protein phosphorylation|retrograde vesicle-mediated transport, Golgi to ER|SNARE complex assembly|double-strand break repair via classical nonhomologous end joining|serine/threonine protein kinase complex|regulation of protein serine/threonine kinase activity - - - - 11:75815167-76143195 166 189 325 495 538 548 0.935119975868964 0.967614121016326 1.65065696726329 2.49840440311256 2.48662357947194 2.89314104131286 1.18446368804953 2.62605634129912 -1.14866389843824 1.1169158719979e-05 0.000111594399071704 DOWN ENSG00000099364 FBXL19 F-box and leucine-rich repeat protein 19 [Source:HGNC Symbol;Acc:HGNC:25300] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0003676|GO:0043169|GO:0000151|GO:0019538|GO:0003677|GO:0046872|GO:0030163|GO:0031461|GO:0044265|GO:1990234|GO:0006508|GO:0044267|GO:0044257|GO:0019005|GO:0010498|GO:0051603|GO:0046914|GO:0019941|GO:0008270|GO:0043161|GO:0006511 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|intracellular|protein binding|protein complex|nucleic acid binding|cation binding|ubiquitin ligase complex|protein metabolic process|DNA binding|metal ion binding|protein catabolic process|cullin-RING ubiquitin ligase complex|cellular macromolecule catabolic process|transferase complex|proteolysis|cellular protein metabolic process|cellular protein catabolic process|SCF ubiquitin ligase complex|proteasomal protein catabolic process|proteolysis involved in cellular protein catabolic process|transition metal ion binding|modification-dependent protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process - - - - 16:30923055-30948783 363 356 326 895 832 620 2.82387651795211 2.51691185968863 2.28649631189912 6.2382020890643 5.31042997755572 4.52021443494606 2.54242822984662 5.35628216718869 -1.07502491451653 1.12086526008761e-05 0.000111914085199516 DOWN ENSG00000164621 SMAD5-AS1 SMAD5 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:30586] - - - - - - 5:136129507-136134890 6 6 6 0 0 0 0.233701199167946 0.212402980437454 0.21072043611249 0 0 0 0.21894153857263 0 Inf 1.13394143778288e-05 0.000113144009637601 UP ENSG00000134871 COL4A2 collagen, type IV, alpha 2 [Source:HGNC Symbol;Acc:HGNC:2203] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0005604|GO:1903561|GO:0051716|GO:0005201|GO:0043229|GO:0005578|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0048514|GO:0005587|GO:0006935|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:1901360|GO:0001568|GO:0007275|GO:0034641|GO:0043062|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0071559|GO:0006928|GO:0048598|GO:0044236|GO:0006139|GO:0001525|GO:0001704|GO:0005783|GO:0070062|GO:0030030|GO:0048869|GO:0044249|GO:0005581|GO:0010033|GO:0016525|GO:0016192|GO:0000902|GO:0031175|GO:0030574|GO:0044259|GO:0034645|GO:0001944|GO:0022617|GO:0072358|GO:0007492|GO:0000904|GO:0009790|GO:0071560|GO:0007369|GO:0045765|GO:0001706|GO:0070848|GO:1901342|GO:0010467|GO:0032990|GO:0005788|GO:0007399|GO:0071310|GO:0097485|GO:0030198|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0072359|GO:0048666|GO:0030182|GO:0007411|GO:0035987|GO:0032774|GO:0071363|GO:0061564|GO:0006897|GO:0022008|GO:0048667|GO:0048812|GO:0006351|GO:0032963|GO:0007409|GO:0048699|GO:0006898 locomotion|developmental process|extracellular matrix|macromolecular complex|structural molecule activity|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|basement membrane|extracellular vesicle|cellular response to stimulus|extracellular matrix structural constituent|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|collagen type IV trimer|chemotaxis|cellular aromatic compound metabolic process|tissue development|cell development|transport|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|cellular nitrogen compound metabolic process|extracellular structure organization|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|response to transforming growth factor beta|movement of cell or subcellular component|embryonic morphogenesis|multicellular organism metabolic process|nucleobase-containing compound metabolic process|angiogenesis|formation of primary germ layer|endoplasmic reticulum|extracellular exosome|cell projection organization|cellular developmental process|cellular biosynthetic process|collagen trimer|response to organic substance|negative regulation of angiogenesis|vesicle-mediated transport|cell morphogenesis|neuron projection development|collagen catabolic process|multicellular organismal macromolecule metabolic process|cellular macromolecule biosynthetic process|vasculature development|extracellular matrix disassembly|cardiovascular system development|endoderm development|cell morphogenesis involved in differentiation|embryo development|cellular response to transforming growth factor beta stimulus|gastrulation|regulation of angiogenesis|endoderm formation|response to growth factor|regulation of vasculature development|gene expression|cell part morphogenesis|endoplasmic reticulum lumen|nervous system development|cellular response to organic substance|neuron projection guidance|extracellular matrix organization|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|circulatory system development|neuron development|neuron differentiation|axon guidance|endodermal cell differentiation|RNA biosynthetic process|cellular response to growth factor stimulus|axon development|endocytosis|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|transcription, DNA-templated|collagen metabolic process|axonogenesis|generation of neurons|receptor-mediated endocytosis K06237 collagen, type IV, alpha[-] hsa05200|hsa04151|hsa04510|hsa04933|hsa05146|hsa04974|hsa05222|hsa04512 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 13:110305812-110513027 211 235 441 605 810 672 1.5189779688608 1.53750726778335 2.86234684234036 3.90231034030003 4.78434052437897 4.53384812915818 1.97294402632817 4.40683299794573 -1.15939219857738 1.13547134272445e-05 0.000113258808772789 DOWN ENSG00000180543 TSPYL5 TSPY-like 5 [Source:HGNC Symbol;Acc:HGNC:29367] GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0071704|GO:0009628|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0040008|GO:0009893|GO:0005622|GO:0005515|GO:0019222|GO:0008284|GO:0042127|GO:0009314|GO:0031325|GO:0022607|GO:0043231|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0009967|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:1902533|GO:0032268|GO:0043412|GO:0006325|GO:0036211|GO:0071478|GO:0051247|GO:0006461|GO:0032270|GO:0010212|GO:0035556|GO:0044267|GO:0051246|GO:1902531|GO:0005634|GO:0051896|GO:0043491|GO:0010332|GO:0031401|GO:0006334|GO:0034622|GO:0034728|GO:0051897|GO:0006333|GO:0065004|GO:0031497|GO:0071479|GO:0006464|GO:0071103|GO:0006323|GO:0071480|GO:0032446|GO:0031398|GO:0031396|GO:0016567 growth|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|intracellular|protein binding|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|response to radiation|positive regulation of cellular metabolic process|cellular component assembly|intracellular membrane-bounded organelle|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|positive regulation of signal transduction|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|macromolecule modification|chromatin organization|protein modification process|cellular response to radiation|positive regulation of protein metabolic process|protein complex assembly|positive regulation of cellular protein metabolic process|response to ionizing radiation|intracellular signal transduction|cellular protein metabolic process|regulation of protein metabolic process|regulation of intracellular signal transduction|nucleus|regulation of protein kinase B signaling|protein kinase B signaling|response to gamma radiation|positive regulation of protein modification process|nucleosome assembly|cellular macromolecular complex assembly|nucleosome organization|positive regulation of protein kinase B signaling|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|cellular response to ionizing radiation|cellular protein modification process|DNA conformation change|DNA packaging|cellular response to gamma radiation|protein modification by small protein conjugation|positive regulation of protein ubiquitination|regulation of protein ubiquitination|protein ubiquitination - - - - 8:97273474-97277964 281 297 234 134 150 131 4.42596876224549 4.25147164153674 3.32301573749912 1.89106608249113 1.93847834557386 1.93375426313451 4.00015204709378 1.92109956373317 1.05812254767939 1.14111137614911e-05 0.000113707406620679 UP ENSG00000260920 RP1-228H13.5 - - - - - - - 1:40464319-40466767 64 88 48 24 26 23 1.84856954329492 2.31003780439286 1.25001214678992 0.621100998102077 0.61617173636378 0.622614819901479 1.8028731648259 0.619962518122445 1.54004500394133 1.15276573310347e-05 0.000114792088712712 UP ENSG00000154839 SKA1 spindle and kinetochore associated complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:28109] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0050794|GO:0043229|GO:0016043|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0022402|GO:0005874|GO:0000776|GO:0051128|GO:0005737|GO:0032886|GO:0032403|GO:0007154|GO:0007165|GO:0008092|GO:0007059|GO:0051301|GO:0007017|GO:0000940|GO:0006996|GO:0015631|GO:0005829|GO:1903047|GO:0007010|GO:0070507|GO:0008017|GO:0000278|GO:0005876|GO:0005694|GO:0035556|GO:0033043|GO:0007067|GO:0000226|GO:0005856|GO:0005819|GO:0000777|GO:0000793|GO:0031110|GO:0051493|GO:0015630|GO:0031109|GO:0007264|GO:0000775|GO:0000779 macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|cellular component organization|intracellular|protein binding|protein complex|cell cycle|cell cycle process|microtubule|kinetochore|regulation of cellular component organization|cytoplasm|regulation of microtubule-based process|protein complex binding|cell communication|signal transduction|cytoskeletal protein binding|chromosome segregation|cell division|microtubule-based process|condensed chromosome outer kinetochore|organelle organization|tubulin binding|cytosol|mitotic cell cycle process|cytoskeleton organization|regulation of microtubule cytoskeleton organization|microtubule binding|mitotic cell cycle|spindle microtubule|chromosome|intracellular signal transduction|regulation of organelle organization|mitotic nuclear division|microtubule cytoskeleton organization|cytoskeleton|spindle|condensed chromosome kinetochore|condensed chromosome|regulation of microtubule polymerization or depolymerization|regulation of cytoskeleton organization|microtubule cytoskeleton|microtubule polymerization or depolymerization|small GTPase mediated signal transduction|chromosome, centromeric region|condensed chromosome, centromeric region - - - - 18:50374995-50394173 514 548 452 218 351 172 8.26335775909731 8.00670508832859 6.55157847059623 3.14013114563765 4.62986739964063 2.59149057726717 7.60721377267404 3.45382970751515 1.13917119528778 1.1609619548383e-05 0.000115569717238221 UP ENSG00000271605 MILR1 mast cell immunoglobulin-like receptor 1 [Source:HGNC Symbol;Acc:HGNC:27570] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0002683|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006955|GO:0051641|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0051640|GO:0006810|GO:0032940|GO:0005887|GO:0043231|GO:0005737|GO:0051656|GO:0001775|GO:0002263|GO:0031226|GO:0050865|GO:0002366|GO:0051649|GO:0002695|GO:0043299|GO:0016021|GO:0002443|GO:0016192|GO:0033004|GO:0043303|GO:0033003|GO:0005773|GO:0006887|GO:0046907|GO:0045576|GO:0046903|GO:0032418|GO:0045055|GO:0000323|GO:0002448|GO:0005764|GO:0042629 immune system process|cell|membrane|cellular process|response to stimulus|binding|negative regulation of immune system process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|immune response|cellular localization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|regulation of immune system process|protein binding|plasma membrane|organelle localization|transport|secretion by cell|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|establishment of organelle localization|cell activation|cell activation involved in immune response|intrinsic component of plasma membrane|regulation of cell activation|leukocyte activation involved in immune response|establishment of localization in cell|negative regulation of leukocyte activation|leukocyte degranulation|integral component of membrane|leukocyte mediated immunity|vesicle-mediated transport|negative regulation of mast cell activation|mast cell degranulation|regulation of mast cell activation|vacuole|exocytosis|intracellular transport|mast cell activation|secretion|lysosome localization|regulated exocytosis|lytic vacuole|mast cell mediated immunity|lysosome|mast cell granule - - - - 17:64449037-64468643 51 56 111 190 176 342 1.27973656003145 1.27708014062713 2.51124402296944 4.27171950550774 3.6235228209745 8.04276182660364 1.68935357454267 5.31266805102863 -1.65296526268341 1.17795047026221e-05 0.000117184404570083 DOWN ENSG00000257674 RP11-76E16.2 - - - - - - - 12:42286911-42288560 1 0 5 12 15 22 0.0428889051046145 0 0.193246597458605 0.460951655322434 0.527636173134356 0.883938150643032 0.0787118341877398 0.624175326366607 -2.98729886483944 1.18831123677641e-05 0.000118095351740089 DOWN ENSG00000189046 ALKBH2 alkB homolog 2, alpha-ketoglutarate-dependent dioxygenase [Source:HGNC Symbol;Acc:HGNC:32487] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0032451|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0006281|GO:0006725|GO:0051213|GO:1901360|GO:0080111|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0016705|GO:0070988|GO:0006139|GO:0051747|GO:0055114|GO:0035511|GO:0070989|GO:0046872|GO:0043412|GO:0031981|GO:0016706|GO:0005654|GO:0006259|GO:0005856|GO:0005634|GO:0006974|GO:0006307|GO:0006304|GO:0015630|GO:0043734|GO:0046914|GO:0005506|GO:0008198 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|demethylase activity|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|DNA repair|cellular aromatic compound metabolic process|dioxygenase activity|organic cyclic compound metabolic process|DNA demethylation|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|demethylation|nucleobase-containing compound metabolic process|cytosine C-5 DNA demethylase activity|oxidation-reduction process|oxidative DNA demethylation|oxidative demethylation|metal ion binding|macromolecule modification|nuclear lumen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|nucleoplasm|DNA metabolic process|cytoskeleton|nucleus|cellular response to DNA damage stimulus|DNA dealkylation involved in DNA repair|DNA modification|microtubule cytoskeleton|DNA-N1-methyladenine dioxygenase activity|transition metal ion binding|iron ion binding|ferrous iron binding - - - - 12:109088188-109093631 469 531 349 211 279 165 5.29116398006196 5.44443187059709 3.54991591480801 2.13283556833362 2.58256234994615 1.7445754075887 4.76183725515569 2.15332444195616 1.1449526074829 1.19120403058653e-05 0.000118343444689285 UP ENSG00000134490 TMEM241 transmembrane protein 241 [Source:HGNC Symbol;Acc:HGNC:31723] GO:0016020|GO:0031224|GO:0006810|GO:0016021|GO:0008643 membrane|intrinsic component of membrane|transport|integral component of membrane|carbohydrate transport - - - - 18:23197144-23437961 54 64 139 219 275 239 0.39998022848666 0.430825898749785 0.928263414482209 1.45339537532005 1.67125352305485 1.65908561406135 0.586356513906218 1.59457817081208 -1.44332480676199 1.19669884776848e-05 0.000118849791754092 DOWN ENSG00000164176 EDIL3 EGF-like repeats and discoidin I-like domains 3 [Source:HGNC Symbol;Acc:HGNC:3173] GO:0032502|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0044877|GO:0050794|GO:0043167|GO:0007155|GO:0043227|GO:0005515|GO:0048856|GO:0007275|GO:0005102|GO:0030155|GO:0031982|GO:0043169|GO:0032403|GO:0031589|GO:0050839|GO:0070062|GO:0045785|GO:0046872|GO:0005178|GO:0010810|GO:0010811|GO:0005509 developmental process|cellular process|extracellular region|binding|extracellular vesicle|macromolecular complex binding|regulation of cellular process|ion binding|cell adhesion|membrane-bounded organelle|protein binding|anatomical structure development|multicellular organism development|receptor binding|regulation of cell adhesion|vesicle|cation binding|protein complex binding|cell-substrate adhesion|cell adhesion molecule binding|extracellular exosome|positive regulation of cell adhesion|metal ion binding|integrin binding|regulation of cell-substrate adhesion|positive regulation of cell-substrate adhesion|calcium ion binding - - - - 5:83940554-84384793 10 13 31 47 72 95 0.0789701495457911 0.0933086247276737 0.220730851593307 0.332567142481094 0.466534623674941 0.703128446481817 0.131003208622257 0.500743404212617 -1.93446936530575 1.2045705096829e-05 0.000119591779168851 DOWN ENSG00000281641 SAMD12-AS1 SAMD12 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:30937] - - - - - - 8:118621001-118858218 2 1 2 11 22 13 0.144207060037034 0.0655634319438729 0.130026609575359 0.710659856849296 1.30159828207478 0.878548138033781 0.113265700518755 0.963602092319286 -3.08872648040527 1.20769123015481e-05 0.000119861748620484 DOWN ENSG00000115318 LOXL3 lysyl oxidase like 3 [Source:HGNC Symbol;Acc:HGNC:13869] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0004872|GO:0009892|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0009890|GO:0006139|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0016638|GO:0038024|GO:0055114|GO:0016192|GO:0000902|GO:0010468|GO:0016641|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0000904|GO:0060485|GO:0048864|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0005044|GO:0048863|GO:0045892|GO:0032774|GO:2001141|GO:0014031|GO:1902679|GO:0046914|GO:0048762|GO:0006897|GO:0004720|GO:0001837|GO:0006351|GO:0006355|GO:1903507|GO:0005507|GO:1903506|GO:0006898 developmental process|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|biosynthetic process|extracellular space|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|cell development|transport|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|oxidoreductase activity, acting on the CH-NH2 group of donors|cargo receptor activity|oxidation-reduction process|vesicle-mediated transport|cell morphogenesis|regulation of gene expression|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|cell morphogenesis involved in differentiation|mesenchyme development|stem cell development|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|scavenger receptor activity|stem cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|mesenchymal cell development|negative regulation of RNA biosynthetic process|transition metal ion binding|mesenchymal cell differentiation|endocytosis|protein-lysine 6-oxidase activity|epithelial to mesenchymal transition|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|copper ion binding|regulation of nucleic acid-templated transcription|receptor-mediated endocytosis - - - - 2:74532414-74555690 156 133 128 63 76 53 1.15295851086667 0.893348824696908 0.852929726310534 0.417180380179759 0.460859606299863 0.367105590379424 0.966412353958037 0.415048525619682 1.21935887743217 1.21305410462854e-05 0.000120314010762725 UP ENSG00000168003 SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 [Source:HGNC Symbol;Acc:HGNC:11026] GO:0040011|GO:0040007|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0097159|GO:0022857|GO:0043229|GO:0006950|GO:0016049|GO:0071704|GO:0050900|GO:0043167|GO:0009986|GO:0045177|GO:0048870|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0050817|GO:0006810|GO:0016324|GO:0003676|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0009611|GO:0005975|GO:0006928|GO:0022891|GO:0055085|GO:0016477|GO:0070062|GO:0016021|GO:0010033|GO:0050878|GO:0003723|GO:0031410|GO:0007596|GO:0016023|GO:0043331|GO:0042060|GO:0006811|GO:0015075|GO:0007599|GO:0031988|GO:0014070|GO:0005634|GO:0034220|GO:0098655|GO:0006820|GO:0015711|GO:0015297|GO:0008509|GO:0006812|GO:0046942|GO:0003725|GO:0046943|GO:0044822|GO:0006865|GO:0043330|GO:0008324|GO:0015804|GO:0015171|GO:0015801|GO:0015827|GO:0042470|GO:0015803|GO:0022890|GO:0015491|GO:0030001|GO:0008514|GO:0015820|GO:0015672|GO:0035725|GO:0015175|GO:0060356|GO:0006814|GO:0015077|GO:0015368|GO:0046873|GO:0006816|GO:0005432|GO:0015085|GO:0015081 locomotion|growth|transporter activity|immune system process|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|response to stress|cell growth|organic substance metabolic process|leukocyte migration|ion binding|cell surface|apical part of cell|cell motility|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|coagulation|transport|apical plasma membrane|nucleic acid binding|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to wounding|carbohydrate metabolic process|movement of cell or subcellular component|substrate-specific transmembrane transporter activity|transmembrane transport|cell migration|extracellular exosome|integral component of membrane|response to organic substance|regulation of body fluid levels|RNA binding|cytoplasmic vesicle|blood coagulation|cytoplasmic, membrane-bounded vesicle|response to dsRNA|wound healing|ion transport|ion transmembrane transporter activity|hemostasis|membrane-bounded vesicle|response to organic cyclic compound|nucleus|ion transmembrane transport|cation transmembrane transport|anion transport|organic anion transport|antiporter activity|anion transmembrane transporter activity|cation transport|carboxylic acid transport|double-stranded RNA binding|carboxylic acid transmembrane transporter activity|poly(A) RNA binding|amino acid transport|response to exogenous dsRNA|cation transmembrane transporter activity|neutral amino acid transport|amino acid transmembrane transporter activity|aromatic amino acid transport|tryptophan transport|melanosome|branched-chain amino acid transport|inorganic cation transmembrane transporter activity|cation:cation antiporter activity|metal ion transport|organic anion transmembrane transporter activity|leucine transport|monovalent inorganic cation transport|sodium ion transmembrane transport|neutral amino acid transmembrane transporter activity|leucine import|sodium ion transport|monovalent inorganic cation transmembrane transporter activity|calcium:cation antiporter activity|metal ion transmembrane transporter activity|calcium ion transport|calcium:sodium antiporter activity|calcium ion transmembrane transporter activity|sodium ion transmembrane transporter activity K06519 solute carrier family 3, member 2[-] hsa04974 Protein digestion and absorption - Homo sapiens (human) 11:62856102-62888875 10144 9703 4602 3795 4174 2110 48.8132420451994 42.4340485400662 19.9659174133707 16.3620561013003 16.4796798305447 9.515679008016 37.0710693328788 14.119138313287 1.39264168693514 1.21951415182703e-05 0.000120874420613028 UP ENSG00000225383 SFTA1P surfactant associated 1, pseudogene [Source:HGNC Symbol;Acc:HGNC:18383] - - - - - - 10:10784437-10794980 198 243 197 92 108 34 7.26070921369915 8.09841618966913 6.51320677851775 3.02272995603559 3.24940221654235 1.16847973553345 7.29077739396201 2.48020396937046 1.55561388182927 1.22415077980238e-05 0.000121293718487289 UP ENSG00000155893 PXYLP1 2-phosphoxylose phosphatase 1 [Source:HGNC Symbol;Acc:HGNC:26303] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0006082|GO:0016788|GO:0044281|GO:0031325|GO:0043231|GO:0005737|GO:0016021|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0006790|GO:0034645|GO:0015012|GO:1903020|GO:0009100|GO:0030201|GO:0051247|GO:0006796|GO:1901137|GO:0000139|GO:0031328|GO:0051246|GO:0009059|GO:0010557|GO:0042578|GO:0010909|GO:0009101|GO:0016311|GO:0010560|GO:0050650|GO:0006024|GO:0010559|GO:0006029|GO:0016791|GO:0030203|GO:0030166|GO:0003993 cell|membrane|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|organic acid metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cytoplasm|integral component of membrane|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|sulfur compound metabolic process|cellular macromolecule biosynthetic process|heparan sulfate proteoglycan biosynthetic process|positive regulation of glycoprotein metabolic process|glycoprotein metabolic process|heparan sulfate proteoglycan metabolic process|positive regulation of protein metabolic process|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|Golgi membrane|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of macromolecule biosynthetic process|phosphoric ester hydrolase activity|positive regulation of heparan sulfate proteoglycan biosynthetic process|glycoprotein biosynthetic process|dephosphorylation|positive regulation of glycoprotein biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process|glycosaminoglycan biosynthetic process|regulation of glycoprotein biosynthetic process|proteoglycan metabolic process|phosphatase activity|glycosaminoglycan metabolic process|proteoglycan biosynthetic process|acid phosphatase activity - - - - 3:141228726-141294906 77 85 171 259 296 342 0.360590285357819 0.361764389366354 0.721995797672704 1.08673259320542 1.13732378896424 1.50099606681203 0.481450157465626 1.24168414966056 -1.36683988354824 1.22969368212779e-05 0.000121762106753709 DOWN ENSG00000275318 RP11-526D8.11 - - - - - - - 9:92840955-92841688 24 24 30 10 8 5 2.31290432112379 2.10203712520118 2.60664143262625 0.863499354316549 0.632604164343351 0.451633846919608 2.34052762631707 0.649245788526503 1.84999713824651 1.2375700017456e-05 0.000122420194937419 UP ENSG00000274423 RP11-544O24.2 - - - - - - - 1:149345661-149357612 72 90 120 222 227 226 8.88844952192579 10.0974820019481 13.3563106362032 24.5551491295515 22.9924201910167 26.1474387567629 10.7807473866924 24.5650026924437 -1.18814719930131 1.24309407806091e-05 0.000122925904625474 DOWN ENSG00000184564 SLITRK6 SLIT and NTRK like family member 6 [Source:HGNC Symbol;Acc:HGNC:23503] GO:0032502|GO:0040007|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0050794|GO:0044089|GO:0009628|GO:0009986|GO:0009653|GO:0016043|GO:0044708|GO:0071944|GO:0009605|GO:0031224|GO:0050793|GO:0048589|GO:0005515|GO:0005886|GO:0007626|GO:0048856|GO:0008344|GO:0090102|GO:0009888|GO:0048468|GO:0030534|GO:0051130|GO:0009612|GO:0048839|GO:0002088|GO:0007275|GO:0007638|GO:0048513|GO:0050877|GO:0001964|GO:0051128|GO:0022607|GO:0050803|GO:0005887|GO:0060004|GO:0007423|GO:0051963|GO:0009887|GO:0035264|GO:0048598|GO:0048568|GO:0060384|GO:0031226|GO:0051965|GO:0050808|GO:0021675|GO:0030030|GO:0048869|GO:0016021|GO:0000902|GO:0031175|GO:0050905|GO:0002093|GO:0007416|GO:0060113|GO:0001654|GO:0050807|GO:0043583|GO:0002064|GO:0000904|GO:0009790|GO:0031223|GO:0042472|GO:0007600|GO:0060005|GO:0060429|GO:0032990|GO:0048562|GO:0007399|GO:0030154|GO:0048858|GO:0010996|GO:0051960|GO:0021545|GO:0048666|GO:0030182|GO:0050953|GO:0050954|GO:0030855|GO:0043010|GO:0002066|GO:0008544|GO:0061564|GO:0042471|GO:0021562|GO:0042491|GO:0060119|GO:0022008|GO:0048667|GO:0060007|GO:0048812|GO:0007605|GO:0007409|GO:0048699|GO:0035315|GO:0060117|GO:0042490|GO:0007601|GO:0009913|GO:0060563 developmental process|growth|behavior|cell|membrane|cellular process|response to stimulus|binding|regulation of cellular process|positive regulation of cellular component biogenesis|response to abiotic stimulus|cell surface|anatomical structure morphogenesis|cellular component organization|single-organism behavior|cell periphery|response to external stimulus|intrinsic component of membrane|regulation of developmental process|developmental growth|protein binding|plasma membrane|locomotory behavior|anatomical structure development|adult locomotory behavior|cochlea development|tissue development|cell development|adult behavior|positive regulation of cellular component organization|response to mechanical stimulus|inner ear development|lens development in camera-type eye|multicellular organism development|mechanosensory behavior|animal organ development|neurological system process|startle response|regulation of cellular component organization|cellular component assembly|regulation of synapse structure or activity|integral component of plasma membrane|reflex|sensory organ development|regulation of synapse assembly|organ morphogenesis|multicellular organism growth|embryonic morphogenesis|embryonic organ development|innervation|intrinsic component of plasma membrane|positive regulation of synapse assembly|synapse organization|nerve development|cell projection organization|cellular developmental process|integral component of membrane|cell morphogenesis|neuron projection development|neuromuscular process|auditory receptor cell morphogenesis|synapse assembly|inner ear receptor cell differentiation|eye development|regulation of synapse organization|ear development|epithelial cell development|cell morphogenesis involved in differentiation|embryo development|auditory behavior|inner ear morphogenesis|sensory perception|vestibular reflex|epithelium development|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|response to auditory stimulus|regulation of nervous system development|cranial nerve development|neuron development|neuron differentiation|sensory perception of light stimulus|sensory perception of mechanical stimulus|epithelial cell differentiation|camera-type eye development|columnar/cuboidal epithelial cell development|epidermis development|axon development|ear morphogenesis|vestibulocochlear nerve development|auditory receptor cell differentiation|inner ear receptor cell development|neurogenesis|cell morphogenesis involved in neuron differentiation|linear vestibuloocular reflex|neuron projection morphogenesis|sensory perception of sound|axonogenesis|generation of neurons|hair cell differentiation|auditory receptor cell development|mechanoreceptor differentiation|visual perception|epidermal cell differentiation|neuroepithelial cell differentiation - - - - 13:85792790-85799488 219 289 415 675 590 876 3.58762066364325 4.30270049224385 6.12950225125564 9.90751108148273 7.93018560725773 13.4491839222261 4.67327446904758 10.4289602036555 -1.15808964767751 1.2478451397074e-05 0.000123314031118254 DOWN ENSG00000263142 LRRC37A17P leucine-rich repeat containing 37 member A17, pseudogene [Source:HGNC Symbol;Acc:HGNC:48365] - - - - - - 17:46978481-47054569 109 158 113 275 334 327 1.51957485151142 2.00185134578104 1.42032972107692 3.43498725736403 3.8204076742072 4.27240616708307 1.64725197278979 3.8426003662181 -1.22202168809035 1.25202854465844e-05 0.000123686499577211 DOWN ENSG00000250903 GMDS-AS1 GMDS antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:48993] - - - - - - 6:2245748-2482022 14 17 20 50 50 69 0.0573044868778618 0.0632400509201511 0.0738086471435176 0.183365026843979 0.167913592728914 0.264684675677917 0.0647843949805102 0.205321098416937 -1.66416363458567 1.25728497318082e-05 0.000124164689346147 DOWN ENSG00000239523 MYLK-AS1 MYLK antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:42440] - - - - - - 3:123585542-123644568 10 9 15 49 38 38 0.409574770979531 0.335041194770987 0.553930171264524 1.79824296492 1.27705425976981 1.4586800181557 0.432848712338347 1.51132574761517 -1.80387987633722 1.26929091700752e-05 0.000125226077449909 DOWN ENSG00000260645 RP11-250B2.5 - - - - - - - 6:80466958-80469080 5 6 12 23 34 54 0.166604307685009 0.181688088777398 0.360497703231541 0.686635681041533 0.929476174109272 1.68622390527517 0.236263366564649 1.10077858680866 -2.22005645400098 1.27999964586576e-05 0.000126240863652714 DOWN ENSG00000111271 ACAD10 acyl-CoA dehydrogenase family member 10 [Source:HGNC Symbol;Acc:HGNC:21597] GO:0009055|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0016787|GO:0005622|GO:0044255|GO:0006082|GO:0043168|GO:0044281|GO:0043231|GO:0005737|GO:0042592|GO:0006629|GO:0016627|GO:0050662|GO:0000166|GO:0000062|GO:0055114|GO:0016042|GO:0050660|GO:0048878|GO:0044242|GO:0006631|GO:0052890|GO:0034440|GO:0005759|GO:0005739|GO:0003995|GO:0030258|GO:0046395|GO:0019752|GO:0055088|GO:0009062|GO:0019395|GO:0006635|GO:0032787|GO:0033539 electron carrier activity|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|hydrolase activity|intracellular|cellular lipid metabolic process|organic acid metabolic process|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|lipid metabolic process|oxidoreductase activity, acting on the CH-CH group of donors|coenzyme binding|nucleotide binding|fatty-acyl-CoA binding|oxidation-reduction process|lipid catabolic process|flavin adenine dinucleotide binding|chemical homeostasis|cellular lipid catabolic process|fatty acid metabolic process|oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor|lipid oxidation|mitochondrial matrix|mitochondrion|acyl-CoA dehydrogenase activity|lipid modification|carboxylic acid catabolic process|carboxylic acid metabolic process|lipid homeostasis|fatty acid catabolic process|fatty acid oxidation|fatty acid beta-oxidation|monocarboxylic acid metabolic process|fatty acid beta-oxidation using acyl-CoA dehydrogenase - - - - 12:111686056-111757107 33 71 93 183 171 232 0.13560514515585 0.265157945409074 0.344556289346463 0.673770143991661 0.5765371753865 0.893470249790371 0.248439793303796 0.714592523056177 -1.52422454614776 1.29284009610987e-05 0.000127338991188598 DOWN ENSG00000159388 BTG2 BTG family member 2 [Source:HGNC Symbol;Acc:HGNC:1131] GO:0032502|GO:0007610|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:1903561|GO:0051716|GO:0032259|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0044708|GO:0009605|GO:0009893|GO:0009058|GO:0005515|GO:0048856|GO:0019222|GO:0042127|GO:0006281|GO:0006725|GO:0051602|GO:0009888|GO:0048468|GO:0021766|GO:0009612|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0050877|GO:0034641|GO:0030900|GO:0031982|GO:0031325|GO:0046483|GO:0033554|GO:0007420|GO:0061061|GO:0010243|GO:0000981|GO:0007389|GO:0060322|GO:0009890|GO:0060548|GO:0006139|GO:0070062|GO:0061351|GO:0009725|GO:0008219|GO:0007611|GO:0008285|GO:0021543|GO:0021542|GO:0030030|GO:0048869|GO:0021537|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0000982|GO:0032268|GO:0031175|GO:0010468|GO:0034645|GO:1901215|GO:0006518|GO:0043412|GO:0007417|GO:0007612|GO:0010629|GO:0043069|GO:2000178|GO:0051252|GO:0006479|GO:0070997|GO:0044265|GO:1901652|GO:0021761|GO:0010628|GO:0036211|GO:0032269|GO:0060537|GO:0003002|GO:0043434|GO:0006259|GO:1901214|GO:0012501|GO:0014070|GO:0043603|GO:0044267|GO:0010467|GO:0007399|GO:0001227|GO:0050890|GO:0019439|GO:0051246|GO:0009059|GO:0030154|GO:0007517|GO:2000177|GO:0016070|GO:0043067|GO:0006974|GO:0048666|GO:0030182|GO:0006401|GO:0060538|GO:0021953|GO:0043043|GO:0001078|GO:0006396|GO:0045892|GO:0043523|GO:0050684|GO:0032774|GO:0017148|GO:0008306|GO:2001141|GO:0010608|GO:1902679|GO:0006412|GO:0016071|GO:0006417|GO:0021954|GO:0035914|GO:0042981|GO:0009952|GO:0043066|GO:0051402|GO:0043524|GO:0014706|GO:0022008|GO:0006464|GO:0061014|GO:0006351|GO:0006915|GO:0006355|GO:0031442|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:0007519|GO:1903506|GO:0006402|GO:0031440|GO:0006397|GO:1900153|GO:0000122|GO:0031123|GO:0000956|GO:0031124|GO:0060213|GO:0000289|GO:0000288 developmental process|behavior|cellular process|extracellular region|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|extracellular vesicle|cellular response to stimulus|methylation|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|single-organism behavior|response to external stimulus|positive regulation of metabolic process|biosynthetic process|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|DNA repair|cellular aromatic compound metabolic process|response to electrical stimulus|tissue development|cell development|hippocampus development|response to mechanical stimulus|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|neurological system process|cellular nitrogen compound metabolic process|forebrain development|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|brain development|muscle structure development|response to organonitrogen compound|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|head development|negative regulation of biosynthetic process|negative regulation of cell death|nucleobase-containing compound metabolic process|extracellular exosome|neural precursor cell proliferation|response to hormone|cell death|learning or memory|negative regulation of cell proliferation|pallium development|dentate gyrus development|cell projection organization|cellular developmental process|telencephalon development|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of cellular protein metabolic process|neuron projection development|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of neuron death|peptide metabolic process|macromolecule modification|central nervous system development|learning|negative regulation of gene expression|negative regulation of programmed cell death|negative regulation of neural precursor cell proliferation|regulation of RNA metabolic process|protein methylation|neuron death|cellular macromolecule catabolic process|response to peptide|limbic system development|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|muscle tissue development|regionalization|response to peptide hormone|DNA metabolic process|regulation of neuron death|programmed cell death|response to organic cyclic compound|cellular amide metabolic process|cellular protein metabolic process|gene expression|nervous system development|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|cognition|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|muscle organ development|regulation of neural precursor cell proliferation|RNA metabolic process|regulation of programmed cell death|cellular response to DNA damage stimulus|neuron development|neuron differentiation|RNA catabolic process|skeletal muscle organ development|central nervous system neuron differentiation|peptide biosynthetic process|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|RNA processing|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|regulation of mRNA processing|RNA biosynthetic process|negative regulation of translation|associative learning|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|translation|mRNA metabolic process|regulation of translation|central nervous system neuron development|skeletal muscle cell differentiation|regulation of apoptotic process|anterior/posterior pattern specification|negative regulation of apoptotic process|neuron apoptotic process|negative regulation of neuron apoptotic process|striated muscle tissue development|neurogenesis|cellular protein modification process|positive regulation of mRNA catabolic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of mRNA 3'-end processing|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|mRNA catabolic process|regulation of mRNA 3'-end processing|mRNA processing|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|negative regulation of transcription from RNA polymerase II promoter|RNA 3'-end processing|nuclear-transcribed mRNA catabolic process|mRNA 3'-end processing|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K14443 protein Tob/BTG[-] hsa03018 RNA degradation - Homo sapiens (human) 1:203305491-203309602 176 214 371 81 84 141 3.12257422307929 3.45058506268394 5.93454306030103 1.28760691387597 1.22277871796439 2.34449181916606 4.16923411535475 1.61829248366881 1.36531000796937 1.29969340512941e-05 0.000127971790622472 UP ENSG00000165309 ARMC3 armadillo repeat containing 3 [Source:HGNC Symbol;Acc:HGNC:30964] GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0005515|GO:0031982|GO:0070062 extracellular region|binding|extracellular vesicle|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 10:22928024-23038523 23 25 43 82 91 87 0.182334566763548 0.180120248418089 0.307335662145923 0.582431643967759 0.59189588451952 0.646370616985934 0.22326349244252 0.606899381824404 -1.44270998700651 1.30429734179056e-05 0.000128382765716503 DOWN ENSG00000180376 CCDC66 coiled-coil domain containing 66 [Source:HGNC Symbol;Acc:HGNC:27709] GO:0032502|GO:0009987|GO:0050896|GO:0051606|GO:0009628|GO:0009653|GO:0009605|GO:0048856|GO:0009791|GO:0060041|GO:0009888|GO:0048468|GO:0009314|GO:0007275|GO:0048513|GO:0060060|GO:0050877|GO:0009582|GO:0007423|GO:0009887|GO:0048729|GO:0050906|GO:0048869|GO:0001654|GO:0009583|GO:0007600|GO:0060042|GO:0007399|GO:0030154|GO:0009416|GO:0048666|GO:0030182|GO:0042461|GO:0050953|GO:0043010|GO:0050908|GO:0009584|GO:0022008|GO:0048592|GO:0048593|GO:0048699|GO:0001754|GO:0042462|GO:0007601|GO:0046548 developmental process|cellular process|response to stimulus|detection of stimulus|response to abiotic stimulus|anatomical structure morphogenesis|response to external stimulus|anatomical structure development|post-embryonic development|retina development in camera-type eye|tissue development|cell development|response to radiation|multicellular organism development|animal organ development|post-embryonic retina morphogenesis in camera-type eye|neurological system process|detection of abiotic stimulus|sensory organ development|organ morphogenesis|tissue morphogenesis|detection of stimulus involved in sensory perception|cellular developmental process|eye development|detection of light stimulus|sensory perception|retina morphogenesis in camera-type eye|nervous system development|cell differentiation|response to light stimulus|neuron development|neuron differentiation|photoreceptor cell development|sensory perception of light stimulus|camera-type eye development|detection of light stimulus involved in visual perception|detection of visible light|neurogenesis|eye morphogenesis|camera-type eye morphogenesis|generation of neurons|eye photoreceptor cell differentiation|eye photoreceptor cell development|visual perception|retinal rod cell development - - - - 3:56557161-56621818 84 82 97 252 229 177 0.350326297473112 0.310804714962779 0.364736995035485 0.941658033796709 0.783605041169289 0.691825822982993 0.341956002490459 0.80569629931633 -1.2364254152396 1.32465084282516e-05 0.000130171580848263 DOWN ENSG00000138587 MNS1 meiosis specific nuclear structural 1 [Source:HGNC Symbol;Acc:HGNC:29636] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0042995|GO:0050794|GO:0043229|GO:0044089|GO:0044702|GO:0051321|GO:0019953|GO:0009653|GO:0016043|GO:0043227|GO:0032504|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0005929|GO:0048646|GO:0048609|GO:0042802|GO:0007049|GO:1902117|GO:0036126|GO:1902115|GO:0051130|GO:0005930|GO:0007275|GO:0051128|GO:0022607|GO:0005882|GO:0043231|GO:0031514|GO:0007389|GO:0005635|GO:0007276|GO:0060491|GO:0045724|GO:0030030|GO:0048869|GO:0006996|GO:0000902|GO:0031344|GO:0048232|GO:0009798|GO:0031346|GO:1902017|GO:0044782|GO:0003002|GO:0030031|GO:0022604|GO:0070925|GO:0042384|GO:0033043|GO:0032990|GO:0048858|GO:0005856|GO:0005634|GO:0010638|GO:0060271|GO:0007283|GO:0045111|GO:0070986|GO:0060972 developmental process|reproduction|cell|cellular process|reproductive process|binding|cell projection|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|single organism reproductive process|meiotic cell cycle|sexual reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|regulation of developmental process|intracellular|protein binding|endomembrane system|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|identical protein binding|cell cycle|positive regulation of organelle assembly|sperm flagellum|regulation of organelle assembly|positive regulation of cellular component organization|axoneme|multicellular organism development|regulation of cellular component organization|cellular component assembly|intermediate filament|intracellular membrane-bounded organelle|motile cilium|pattern specification process|nuclear envelope|gamete generation|regulation of cell projection assembly|positive regulation of cilium assembly|cell projection organization|cellular developmental process|organelle organization|cell morphogenesis|regulation of cell projection organization|male gamete generation|axis specification|positive regulation of cell projection organization|regulation of cilium assembly|cilium organization|regionalization|cell projection assembly|regulation of cell morphogenesis|organelle assembly|cilium assembly|regulation of organelle organization|cell part morphogenesis|cell projection morphogenesis|cytoskeleton|nucleus|positive regulation of organelle organization|cilium morphogenesis|spermatogenesis|intermediate filament cytoskeleton|left/right axis specification|left/right pattern formation - - - - 15:56421544-56465137 84 124 138 297 329 224 1.96751136802697 2.63961107874325 2.91429501009445 6.23294837788592 6.32269822639186 4.91716569540374 2.50713915228822 5.82427076656051 -1.21603535559097 1.34689684829457e-05 0.000132314111579421 DOWN ENSG00000146243 IRAK1BP1 interleukin 1 receptor associated kinase 1 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17368] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0006955|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0035556|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0007249|GO:0006351|GO:0006355|GO:1903506 immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|immune response|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|intracellular signal transduction|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|I-kappaB kinase/NF-kappaB signaling|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 6:78867472-78946440 23 33 48 85 99 118 0.183341372462378 0.239070474787825 0.344971799356379 0.607078225833991 0.647482568497494 0.881530898025283 0.255794548868861 0.712030564118923 -1.47695365075107 1.34912997161343e-05 0.000132480430425375 DOWN ENSG00000147509 RGS20 regulator of G-protein signaling 20 [Source:HGNC Symbol;Acc:HGNC:14600] GO:0032502|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0060341|GO:0001756|GO:0006725|GO:0009888|GO:0008013|GO:0006810|GO:1901360|GO:0005938|GO:0007275|GO:0034641|GO:0008047|GO:0005874|GO:0031982|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0007389|GO:0032880|GO:0030877|GO:0009966|GO:0045184|GO:0014069|GO:0019904|GO:0010646|GO:0006139|GO:0043085|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0051649|GO:0008219|GO:0050790|GO:0048869|GO:0044249|GO:0010033|GO:0031323|GO:0005794|GO:0030111|GO:0007186|GO:0010468|GO:0034645|GO:0030178|GO:0005096|GO:0005802|GO:0007166|GO:0072594|GO:0031410|GO:0051345|GO:0008277|GO:0009798|GO:0030695|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0009790|GO:0016023|GO:0070201|GO:0046907|GO:0003002|GO:0031988|GO:0034613|GO:0019900|GO:0014070|GO:0060429|GO:0010467|GO:0017038|GO:0071310|GO:0009059|GO:0030154|GO:0005881|GO:1903827|GO:0016070|GO:0005856|GO:0005634|GO:0090244|GO:0070016|GO:0006606|GO:0016055|GO:1904589|GO:0033365|GO:0033157|GO:0009792|GO:0090090|GO:0051169|GO:0060828|GO:0032774|GO:2001141|GO:0043087|GO:0006605|GO:0071407|GO:0016482|GO:0061053|GO:0006886|GO:0043547|GO:0015630|GO:0009953|GO:0009952|GO:0042306|GO:1900180|GO:0019901|GO:0009950|GO:0035411|GO:0006351|GO:0035282|GO:0006355|GO:1903533|GO:0006913|GO:0035412|GO:1903506|GO:0060070|GO:0043009|GO:0034504|GO:0046822|GO:0051170 developmental process|macromolecular complex|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cellular localization|somitogenesis|cellular aromatic compound metabolic process|tissue development|beta-catenin binding|transport|organic cyclic compound metabolic process|cell cortex|multicellular organism development|cellular nitrogen compound metabolic process|enzyme activator activity|microtubule|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|pattern specification process|regulation of protein localization|beta-catenin destruction complex|regulation of signal transduction|establishment of protein localization|postsynaptic density|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|cell communication|signal transduction|negative regulation of signal transduction|establishment of localization in cell|cell death|regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|regulation of Wnt signaling pathway|G-protein coupled receptor signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|GTPase activator activity|trans-Golgi network|cell surface receptor signaling pathway|establishment of protein localization to organelle|cytoplasmic vesicle|positive regulation of hydrolase activity|regulation of G-protein coupled receptor protein signaling pathway|axis specification|GTPase regulator activity|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|embryo development|cytoplasmic, membrane-bounded vesicle|regulation of establishment of protein localization|intracellular transport|regionalization|membrane-bounded vesicle|cellular protein localization|kinase binding|response to organic cyclic compound|epithelium development|gene expression|protein import|cellular response to organic substance|macromolecule biosynthetic process|cell differentiation|cytoplasmic microtubule|regulation of cellular protein localization|RNA metabolic process|cytoskeleton|nucleus|Wnt signaling pathway involved in somitogenesis|armadillo repeat domain binding|protein import into nucleus|Wnt signaling pathway|regulation of protein import|protein localization to organelle|regulation of intracellular protein transport|embryo development ending in birth or egg hatching|negative regulation of canonical Wnt signaling pathway|nuclear transport|regulation of canonical Wnt signaling pathway|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of GTPase activity|protein targeting|cellular response to organic cyclic compound|cytosolic transport|somite development|intracellular protein transport|positive regulation of GTPase activity|microtubule cytoskeleton|dorsal/ventral pattern formation|anterior/posterior pattern specification|regulation of protein import into nucleus|regulation of protein localization to nucleus|protein kinase binding|dorsal/ventral axis specification|catenin import into nucleus|transcription, DNA-templated|segmentation|regulation of transcription, DNA-templated|regulation of protein targeting|nucleocytoplasmic transport|regulation of catenin import into nucleus|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|chordate embryonic development|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import - - - - 8:53851808-53959303 58 36 56 150 176 113 0.636479279218161 0.359035506491856 0.554065182045023 1.47483824076404 1.58465883219471 1.16214799029435 0.516526655918347 1.40721502108437 -1.44592807984811 1.34947741985518e-05 0.000132480430425375 DOWN ENSG00000186026 ZNF284 zinc finger protein 284 [Source:HGNC Symbol;Acc:HGNC:13078] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:44072144-44089613 183 197 294 99 98 128 2.97514858619369 2.91073981480914 4.30941853563723 1.44207768198908 1.30722942004398 1.95027192820132 3.39843564554669 1.56652634341146 1.11730177256707 1.35687904564926e-05 0.00013307577867547 UP ENSG00000260317 RP11-48B3.4 - - - - - - - 8:80541300-80543104 2 0 1 13 12 9 0.0783751390007369 0 0.0353156109805233 0.456464833674697 0.385854916491725 0.330549709224302 0.0378969166604201 0.390956486463575 -3.36685566536913 1.364365719963e-05 0.000133722174011082 DOWN ENSG00000158406 HIST1H4H histone cluster 1, H4h [Source:HGNC Symbol;Acc:HGNC:4788] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0032259|GO:0002683|GO:0097159|GO:0009892|GO:0048523|GO:0032451|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0032993|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0007049|GO:1903706|GO:0006281|GO:0045595|GO:0006725|GO:0042393|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0032452|GO:0031982|GO:0046483|GO:0033554|GO:0006482|GO:0022607|GO:0043231|GO:0000723|GO:0042592|GO:0046983|GO:0070988|GO:0009890|GO:0019904|GO:0016458|GO:0006139|GO:0007154|GO:0007165|GO:0070062|GO:0048869|GO:0044249|GO:0000786|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:1901533|GO:0000725|GO:0003723|GO:0043412|GO:0030097|GO:0031047|GO:0010629|GO:0046982|GO:0051252|GO:0006325|GO:0006302|GO:0036211|GO:0000278|GO:0006306|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0006461|GO:0016577|GO:0006342|GO:0035556|GO:0044267|GO:0010467|GO:0009059|GO:0030154|GO:0035575|GO:0016070|GO:0005634|GO:0045638|GO:0006974|GO:0045637|GO:1901532|GO:0006303|GO:0045814|GO:0000724|GO:0032200|GO:0006334|GO:0000781|GO:0034622|GO:0051259|GO:0045892|GO:0032774|GO:2001141|GO:0034728|GO:1902679|GO:0006304|GO:0034508|GO:0040029|GO:0070076|GO:0006333|GO:0045653|GO:0000183|GO:0032776|GO:0065004|GO:0006310|GO:0031497|GO:0000784|GO:0016568|GO:0044822|GO:0002244|GO:0030099|GO:0007264|GO:0006464|GO:0045652|GO:0071103|GO:0006351|GO:0006355|GO:0006336|GO:0006323|GO:0006335|GO:0043486|GO:1903507|GO:0006352|GO:0051291|GO:1903506|GO:0030219|GO:0006338|GO:0035574|GO:0051262|GO:0034080|GO:0043044|GO:0051290 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|methylation|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|demethylase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|protein-DNA complex|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|cell cycle|regulation of hemopoiesis|DNA repair|regulation of cell differentiation|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|histone demethylase activity|vesicle|heterocycle metabolic process|cellular response to stress|protein demethylation|cellular component assembly|intracellular membrane-bounded organelle|telomere maintenance|homeostatic process|protein dimerization activity|demethylation|negative regulation of biosynthetic process|protein domain specific binding|gene silencing|nucleobase-containing compound metabolic process|cell communication|signal transduction|extracellular exosome|cellular developmental process|cellular biosynthetic process|nucleosome|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of hematopoietic progenitor cell differentiation|recombinational repair|RNA binding|macromolecule modification|hemopoiesis|gene silencing by RNA|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|chromatin organization|double-strand break repair|protein modification process|mitotic cell cycle|DNA methylation|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|protein complex assembly|histone demethylation|chromatin silencing|intracellular signal transduction|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|histone demethylase activity (H4-K20 specific)|RNA metabolic process|nucleus|negative regulation of myeloid cell differentiation|cellular response to DNA damage stimulus|regulation of myeloid cell differentiation|regulation of hematopoietic progenitor cell differentiation|double-strand break repair via nonhomologous end joining|negative regulation of gene expression, epigenetic|double-strand break repair via homologous recombination|telomere organization|nucleosome assembly|chromosome, telomeric region|cellular macromolecular complex assembly|protein oligomerization|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nucleosome organization|negative regulation of RNA biosynthetic process|DNA modification|centromere complex assembly|regulation of gene expression, epigenetic|histone lysine demethylation|chromatin assembly or disassembly|negative regulation of megakaryocyte differentiation|chromatin silencing at rDNA|DNA methylation on cytosine|protein-DNA complex assembly|DNA recombination|chromatin assembly|nuclear chromosome, telomeric region|chromatin modification|poly(A) RNA binding|hematopoietic progenitor cell differentiation|myeloid cell differentiation|small GTPase mediated signal transduction|cellular protein modification process|regulation of megakaryocyte differentiation|DNA conformation change|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA replication-independent nucleosome assembly|DNA packaging|DNA replication-dependent nucleosome assembly|histone exchange|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|protein heterooligomerization|regulation of nucleic acid-templated transcription|megakaryocyte differentiation|chromatin remodeling|histone H4-K20 demethylation|protein tetramerization|CENP-A containing nucleosome assembly|ATP-dependent chromatin remodeling|protein heterotetramerization K11254 histone H4[-] hsa05203|hsa05034|hsa05322 Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 6:26277609-26285638 33 44 34 90 108 112 0.649501104260655 0.787045434468296 0.603335286459244 1.58711307178046 1.74404476230111 2.06592103507503 0.679960608396065 1.79902628971887 -1.4036931938652 1.37030334787013e-05 0.000134244852884134 DOWN ENSG00000183055 FAM133CP family with sequence similarity 133 member C, pseudogene [Source:HGNC Symbol;Acc:HGNC:44190] - - - - - - 10:58715554-58716257 67 54 35 19 12 18 6.73207475972756 4.93112828447408 3.17073642856265 1.71051724492022 0.989301312880061 1.69500632144848 4.94464649092143 1.46494162641625 1.75502420297703 1.3710476198959e-05 0.000134244852884134 UP ENSG00000115423 DNAH6 dynein, axonemal, heavy chain 6 [Source:HGNC Symbol;Acc:HGNC:2951] GO:0040011|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0043229|GO:0043167|GO:0048870|GO:0016787|GO:0005622|GO:0043234|GO:0005929|GO:0001539|GO:0005930|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0006928|GO:0005875|GO:0000166|GO:0007017|GO:0005858|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0007018|GO:0030286|GO:0017076|GO:0005856|GO:0005524|GO:0030554|GO:0015630|GO:0016462|GO:0017111|GO:0016887|GO:0003774|GO:0003777 locomotion|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|intracellular organelle|ion binding|cell motility|hydrolase activity|intracellular|protein complex|cilium|cilium or flagellum-dependent cell motility|axoneme|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|movement of cell or subcellular component|microtubule associated complex|nucleotide binding|microtubule-based process|axonemal dynein complex|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|microtubule-based movement|dynein complex|purine nucleotide binding|cytoskeleton|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|motor activity|microtubule motor activity K10408 dynein heavy chain, axonemal[-] hsa05016 Huntington,s disease - Homo sapiens (human) 2:84516455-84819589 0 0 1 6 7 16 0 0 0.00417915674423684 0.0249318242733238 0.0266352998782972 0.0695412679174125 0.00139305224807895 0.0403694640230112 -4.85694315852577 1.38459594156747e-05 0.000135459100412942 DOWN ENSG00000198824 CHAMP1 chromosome alignment maintaining phosphoprotein 1 [Source:HGNC Symbol;Acc:HGNC:20311] GO:0032991|GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0022402|GO:0003676|GO:0000776|GO:0043231|GO:0043169|GO:0005737|GO:0008104|GO:0007059|GO:0006996|GO:0051276|GO:0000819|GO:0046872|GO:1903047|GO:0000278|GO:0031981|GO:0005654|GO:0005694|GO:0034613|GO:0007067|GO:0008608|GO:0005856|GO:0005634|GO:0005819|GO:0000777|GO:0051315|GO:0033365|GO:0000793|GO:0031134|GO:0015630|GO:0000070|GO:0000775|GO:0034502|GO:0000779|GO:0044380|GO:0071459|GO:0035372|GO:0034501 macromolecular complex|cell|cellular process|binding|organic cyclic compound binding|intracellular organelle|ion binding|cellular localization|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|cell cycle process|nucleic acid binding|kinetochore|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein localization|chromosome segregation|organelle organization|chromosome organization|sister chromatid segregation|metal ion binding|mitotic cell cycle process|mitotic cell cycle|nuclear lumen|nucleoplasm|chromosome|cellular protein localization|mitotic nuclear division|attachment of spindle microtubules to kinetochore|cytoskeleton|nucleus|spindle|condensed chromosome kinetochore|attachment of mitotic spindle microtubules to kinetochore|protein localization to organelle|condensed chromosome|sister chromatid biorientation|microtubule cytoskeleton|mitotic sister chromatid segregation|chromosome, centromeric region|protein localization to chromosome|condensed chromosome, centromeric region|protein localization to cytoskeleton|protein localization to chromosome, centromeric region|protein localization to microtubule|protein localization to kinetochore - - - - 13:114314513-114327328 1546 1737 871 692 750 592 22.5065220026607 22.9815179737874 11.4322387733139 9.02615255917937 8.95835511268963 8.07699062279013 18.9734262499207 8.68716609821971 1.12702269915532 1.38480999015307e-05 0.000135459100412942 UP ENSG00000144061 NPHP1 nephronophthisis 1 (juvenile) [Source:HGNC Symbol;Acc:HGNC:7905] GO:0032502|GO:0000003|GO:0007610|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0044702|GO:0009628|GO:0019953|GO:0003006|GO:0005911|GO:0016043|GO:0007155|GO:0044708|GO:0032504|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048609|GO:0016337|GO:0060041|GO:0009314|GO:0007275|GO:0048513|GO:0005912|GO:0007632|GO:0098609|GO:0031514|GO:0005737|GO:0007423|GO:0048515|GO:0072372|GO:0007154|GO:0007276|GO:0007165|GO:0007588|GO:0030030|GO:0048869|GO:0030029|GO:0043296|GO:0006996|GO:0005829|GO:0048232|GO:0001654|GO:0007010|GO:0030036|GO:0030154|GO:0005923|GO:0005856|GO:0009416|GO:0031513|GO:0007283|GO:0032391|GO:0043010 developmental process|reproduction|behavior|structural molecule activity|signaling|cell|membrane|cellular process|reproductive process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|single organism reproductive process|response to abiotic stimulus|sexual reproduction|developmental process involved in reproduction|cell-cell junction|cellular component organization|cell adhesion|single-organism behavior|multicellular organism reproduction|intracellular|protein binding|anatomical structure development|cilium|multicellular organismal reproductive process|single organismal cell-cell adhesion|retina development in camera-type eye|response to radiation|multicellular organism development|animal organ development|adherens junction|visual behavior|cell-cell adhesion|motile cilium|cytoplasm|sensory organ development|spermatid differentiation|primary cilium|cell communication|gamete generation|signal transduction|excretion|cell projection organization|cellular developmental process|actin filament-based process|apical junction complex|organelle organization|cytosol|male gamete generation|eye development|cytoskeleton organization|actin cytoskeleton organization|cell differentiation|bicellular tight junction|cytoskeleton|response to light stimulus|nonmotile primary cilium|spermatogenesis|photoreceptor connecting cilium|camera-type eye development - - - - 2:110122311-110205066 46 62 85 156 155 193 0.198093048673651 0.242652668263869 0.330023593622081 0.601917229733714 0.547662616899799 0.778934052304812 0.256923103519867 0.642837966312775 -1.32311850898322 1.40549173289437e-05 0.000137347136477343 DOWN ENSG00000049283 EPN3 epsin 3 [Source:HGNC Symbol;Acc:HGNC:18235] GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0019898|GO:0043229|GO:0043227|GO:0008289|GO:0071944|GO:0005905|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031982|GO:0043231|GO:0005737|GO:0019897|GO:0019904|GO:0070062|GO:0031410|GO:1990175|GO:0016023|GO:0031981|GO:0048471|GO:0031988|GO:0005654|GO:0005634|GO:0030135|GO:0030136 cell|membrane|extracellular region|binding|extracellular vesicle|extrinsic component of membrane|intracellular organelle|membrane-bounded organelle|lipid binding|cell periphery|coated pit|intracellular|protein binding|plasma membrane|endomembrane system|vesicle|intracellular membrane-bounded organelle|cytoplasm|extrinsic component of plasma membrane|protein domain specific binding|extracellular exosome|cytoplasmic vesicle|EH domain binding|cytoplasmic, membrane-bounded vesicle|nuclear lumen|perinuclear region of cytoplasm|membrane-bounded vesicle|nucleoplasm|nucleus|coated vesicle|clathrin-coated vesicle K12471 epsin[-] hsa04144 Endocytosis - Homo sapiens (human) 17:50532543-50543750 175 217 262 405 568 472 0.906748955024503 1.02185577027659 1.22395124411535 1.88019189202355 2.41471385419159 2.29203199211144 1.05085198980548 2.19564591277553 -1.06308592950802 1.41854703023823e-05 0.000138516298684424 DOWN ENSG00000204261 PSMB8-AS1 PSMB8 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:39758] - - - - - - 6:32844086-32846495 52 50 67 12 30 20 0.621656930226682 0.54324237011213 0.722161460410546 0.128539839662332 0.2942608162911 0.224075704082333 0.629020253583119 0.215625453345255 1.54457898064044 1.42014635740672e-05 0.000138597742249167 UP ENSG00000051825 MPHOSPH9 M-phase phosphoprotein 9 [Source:HGNC Symbol;Acc:HGNC:7215] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0043231|GO:0005737|GO:0005794|GO:0005813|GO:0005815|GO:0005814|GO:0000139|GO:0005856|GO:0015630 cell|membrane|intracellular organelle|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|Golgi apparatus|centrosome|microtubule organizing center|centriole|Golgi membrane|cytoskeleton|microtubule cytoskeleton - - - - 12:123152320-123244014 221 265 294 497 553 604 0.940263030885836 1.02467012363835 1.12776855819545 1.89457631391183 1.93041813864434 2.40837224211598 1.03090057090655 2.07778889822405 -1.01114389171417 1.42097680574032e-05 0.000138633469145658 DOWN ENSG00000184640 SEPT9 septin 9 [Source:HGNC Symbol;Acc:HGNC:7323] GO:0005623|GO:0009987|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0016043|GO:0016787|GO:0005622|GO:0005515|GO:0007049|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0022607|GO:0005737|GO:0000166|GO:0051301|GO:0035639|GO:0001883|GO:0016818|GO:0032432|GO:0032549|GO:0048471|GO:0006461|GO:0042641|GO:0017076|GO:0005856|GO:0015629|GO:0032561|GO:0051259|GO:0001725|GO:0015630|GO:0005525|GO:0019001|GO:0016462|GO:0051291|GO:0017111|GO:0003924 cell|cellular process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|cellular component organization|hydrolase activity|intracellular|protein binding|cell cycle|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|cellular component assembly|cytoplasm|nucleotide binding|cell division|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|actin filament bundle|ribonucleoside binding|perinuclear region of cytoplasm|protein complex assembly|actomyosin|purine nucleotide binding|cytoskeleton|actin cytoskeleton|guanyl ribonucleotide binding|protein oligomerization|stress fiber|microtubule cytoskeleton|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|protein heterooligomerization|nucleoside-triphosphatase activity|GTPase activity K16938 septin 3/9/12[-] hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) 17:77280569-77500596 1360 1689 3054 4319 4835 4432 3.16704475092275 3.57457879032255 6.41207196217669 9.01147950505302 9.23803405181124 9.67261337156001 4.38456516780733 9.30737564280809 -1.08594066234261 1.42329155503589e-05 0.000138813936896574 DOWN ENSG00000185344 ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 [Source:HGNC Symbol;Acc:HGNC:18481] GO:0032991|GO:0005215|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0022857|GO:0030055|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0006955|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0005924|GO:0044281|GO:0005912|GO:0031982|GO:0019637|GO:0046483|GO:0016817|GO:0022607|GO:0030141|GO:0043231|GO:0019899|GO:0033177|GO:0010243|GO:0005774|GO:0005737|GO:0012506|GO:0042592|GO:0030666|GO:0045184|GO:0019725|GO:0022891|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0001669|GO:0009725|GO:0016469|GO:0010008|GO:0016021|GO:0044249|GO:0010033|GO:0005768|GO:0006996|GO:0016820|GO:0007166|GO:0031410|GO:0019693|GO:0048878|GO:0016471|GO:0051117|GO:0015031|GO:1901652|GO:0005773|GO:0071417|GO:0016023|GO:0016818|GO:0009116|GO:0006811|GO:0033176|GO:0055082|GO:0015075|GO:0090382|GO:0043434|GO:0031988|GO:0006461|GO:0006796|GO:0030659|GO:1901137|GO:0071310|GO:0033179|GO:0000220|GO:0090662|GO:0032870|GO:0030670|GO:0005925|GO:0034220|GO:0033572|GO:0009142|GO:0098655|GO:0009124|GO:0034622|GO:0030139|GO:0009259|GO:1901653|GO:0000323|GO:0009117|GO:0015992|GO:0046390|GO:0006812|GO:0043623|GO:0015991|GO:0007167|GO:0042625|GO:0071375|GO:0006163|GO:0050801|GO:0032868|GO:0042626|GO:0009165|GO:0016462|GO:0042278|GO:0005765|GO:0006873|GO:0008324|GO:0019829|GO:0006164|GO:0005764|GO:1902600|GO:0017111|GO:0045335|GO:0032869|GO:0022890|GO:0030001|GO:0030003|GO:0015672|GO:0009156|GO:0007169|GO:0016887|GO:0046034|GO:0055065|GO:0009152|GO:0046961|GO:0006875|GO:0009168|GO:0015077|GO:0008286|GO:0042623|GO:0015078|GO:0006885|GO:0030641|GO:0006754|GO:0015986|GO:0006826|GO:0070072|GO:0006879|GO:0051453|GO:0055072|GO:0043492|GO:0045851|GO:0051452|GO:0007035 macromolecular complex|transporter activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|transmembrane transporter activity|cell-substrate junction|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|immune response|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|cell-substrate adherens junction|small molecule metabolic process|adherens junction|vesicle|organophosphate metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|cellular component assembly|secretory granule|intracellular membrane-bounded organelle|enzyme binding|proton-transporting two-sector ATPase complex, proton-transporting domain|response to organonitrogen compound|vacuolar membrane|cytoplasm|vesicle membrane|homeostatic process|endocytic vesicle membrane|establishment of protein localization|cellular homeostasis|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|transmembrane transport|signal transduction|acrosomal vesicle|response to hormone|proton-transporting two-sector ATPase complex|endosome membrane|integral component of membrane|cellular biosynthetic process|response to organic substance|endosome|organelle organization|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|cell surface receptor signaling pathway|cytoplasmic vesicle|ribose phosphate metabolic process|chemical homeostasis|vacuolar proton-transporting V-type ATPase complex|ATPase binding|protein transport|response to peptide|vacuole|cellular response to organonitrogen compound|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nucleoside metabolic process|ion transport|proton-transporting V-type ATPase complex|cellular chemical homeostasis|ion transmembrane transporter activity|phagosome maturation|response to peptide hormone|membrane-bounded vesicle|protein complex assembly|phosphate-containing compound metabolic process|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular response to organic substance|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase, V0 domain|ATP hydrolysis coupled transmembrane transport|cellular response to hormone stimulus|phagocytic vesicle membrane|focal adhesion|ion transmembrane transport|transferrin transport|nucleoside triphosphate biosynthetic process|cation transmembrane transport|nucleoside monophosphate biosynthetic process|cellular macromolecular complex assembly|endocytic vesicle|ribonucleotide metabolic process|cellular response to peptide|lytic vacuole|nucleotide metabolic process|proton transport|ribose phosphate biosynthetic process|cation transport|cellular protein complex assembly|ATP hydrolysis coupled proton transport|enzyme linked receptor protein signaling pathway|ATPase coupled ion transmembrane transporter activity|cellular response to peptide hormone stimulus|purine nucleotide metabolic process|ion homeostasis|response to insulin|ATPase activity, coupled to transmembrane movement of substances|nucleotide biosynthetic process|pyrophosphatase activity|purine nucleoside metabolic process|lysosomal membrane|cellular ion homeostasis|cation transmembrane transporter activity|cation-transporting ATPase activity|purine nucleotide biosynthetic process|lysosome|hydrogen ion transmembrane transport|nucleoside-triphosphatase activity|phagocytic vesicle|cellular response to insulin stimulus|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|monovalent inorganic cation transport|ribonucleoside monophosphate biosynthetic process|transmembrane receptor protein tyrosine kinase signaling pathway|ATPase activity|ATP metabolic process|metal ion homeostasis|purine ribonucleotide biosynthetic process|proton-transporting ATPase activity, rotational mechanism|cellular metal ion homeostasis|purine ribonucleoside monophosphate biosynthetic process|monovalent inorganic cation transmembrane transporter activity|insulin receptor signaling pathway|ATPase activity, coupled|hydrogen ion transmembrane transporter activity|regulation of pH|regulation of cellular pH|ATP biosynthetic process|ATP synthesis coupled proton transport|iron ion transport|vacuolar proton-transporting V-type ATPase complex assembly|cellular iron ion homeostasis|regulation of intracellular pH|iron ion homeostasis|ATPase activity, coupled to movement of substances|pH reduction|intracellular pH reduction|vacuolar acidification K02154 V-type H+-transporting ATPase subunit a[-] hsa01100|hsa05152|hsa04145|hsa00190|hsa04142|hsa05323|hsa05120|hsa04721|hsa05110|hsa04966 Metabolic pathways - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human)|Lysosome - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Synaptic vesicle cycle - Homo sapiens (human)|Vibrio cholerae infection - Homo sapiens (human)|Collecting duct acid secretion - Homo sapiens (human) 12:123712318-123761755 524 597 425 277 321 225 2.27483182579537 2.35544063863154 1.66349400030005 1.0774448907008 1.1433825523766 0.915441061878447 2.09792215490899 1.04542283498528 1.00487456926093 1.44129406910805e-05 0.000140432092490704 UP ENSG00000224280 AC005014.5 - - - - - - - 7:16583782-16586757 10 20 8 1 1 2 0.237679983024748 0.432038320423854 0.171446376335251 0.021286556955918 0.0195104931399034 0.0445468718936277 0.280388226594618 0.028447973996483 3.30102795668543 1.44468669724525e-05 0.00014062496465458 UP ENSG00000160991 ORAI2 ORAI calcium release-activated calcium modulator 2 [Source:HGNC Symbol;Acc:HGNC:21667] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0022857|GO:0030427|GO:0031224|GO:0005515|GO:0006810|GO:0030426|GO:0043005|GO:0022891|GO:0055085|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0034220|GO:0098655|GO:0005216|GO:0006812|GO:0008324|GO:0022890|GO:0030001|GO:0005261|GO:0005262|GO:0070588|GO:0046873|GO:0015279|GO:0006816|GO:0015085|GO:0002115 transporter activity|cell|membrane|cellular process|binding|cell projection|transmembrane transporter activity|site of polarized growth|intrinsic component of membrane|protein binding|transport|growth cone|neuron projection|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|ion channel activity|cation transport|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|calcium channel activity|calcium ion transmembrane transport|metal ion transmembrane transporter activity|store-operated calcium channel activity|calcium ion transport|calcium ion transmembrane transporter activity|store-operated calcium entry K16057 calcium release-activated calcium channel protein 2[-] hsa04020 Calcium signaling pathway - Homo sapiens (human) 7:102433106-102456821 116 150 225 336 428 391 0.356698437996893 0.419192110583395 0.623791279052121 0.925719925906971 1.07982563713051 1.12680273922823 0.466560609210803 1.04411610075524 -1.16214572798108 1.44574945360867e-05 0.000140682542985767 DOWN ENSG00000085872 CHERP calcium homeostasis endoplasmic reticulum protein [Source:HGNC Symbol;Acc:HGNC:16930] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0005622|GO:0005789|GO:1903829|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0060341|GO:0042127|GO:0051282|GO:0006725|GO:0044325|GO:0006810|GO:1901360|GO:0033017|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0032880|GO:0051222|GO:0042592|GO:0045184|GO:0019725|GO:0032388|GO:0006139|GO:1900182|GO:0008104|GO:0055085|GO:0005783|GO:0051649|GO:2000021|GO:0090316|GO:0008285|GO:0051238|GO:0042307|GO:0016528|GO:0003723|GO:0072594|GO:0048878|GO:0032386|GO:0051223|GO:0015031|GO:0051208|GO:0070201|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0048471|GO:1904591|GO:0034613|GO:0010467|GO:0017038|GO:0007399|GO:1903827|GO:0016070|GO:0016529|GO:0006606|GO:0034220|GO:1904589|GO:0098655|GO:0033365|GO:0033157|GO:0051169|GO:0006396|GO:0006812|GO:0006605|GO:0060402|GO:0016482|GO:0006886|GO:0042993|GO:0050801|GO:0044822|GO:0042306|GO:1900180|GO:0042991|GO:0006873|GO:0046824|GO:1903533|GO:0006913|GO:0051533|GO:0051531|GO:0030001|GO:0042990|GO:0030003|GO:0034504|GO:0046822|GO:0051170|GO:0070588|GO:0055065|GO:0097553|GO:0006875|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|intracellular|endoplasmic reticulum membrane|positive regulation of cellular protein localization|protein binding|endomembrane system|anatomical structure development|organelle membrane|regulation of cellular localization|regulation of cell proliferation|regulation of sequestering of calcium ion|cellular aromatic compound metabolic process|ion channel binding|transport|organic cyclic compound metabolic process|sarcoplasmic reticulum membrane|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|positive regulation of protein transport|homeostatic process|establishment of protein localization|cellular homeostasis|positive regulation of intracellular transport|nucleobase-containing compound metabolic process|positive regulation of protein localization to nucleus|protein localization|transmembrane transport|endoplasmic reticulum|establishment of localization in cell|regulation of ion homeostasis|positive regulation of intracellular protein transport|negative regulation of cell proliferation|sequestering of metal ion|positive regulation of protein import into nucleus|sarcoplasm|RNA binding|establishment of protein localization to organelle|chemical homeostasis|regulation of intracellular transport|regulation of protein transport|protein transport|sequestering of calcium ion|regulation of establishment of protein localization|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|perinuclear region of cytoplasm|positive regulation of protein import|cellular protein localization|gene expression|protein import|nervous system development|regulation of cellular protein localization|RNA metabolic process|sarcoplasmic reticulum|protein import into nucleus|ion transmembrane transport|regulation of protein import|cation transmembrane transport|protein localization to organelle|regulation of intracellular protein transport|nuclear transport|RNA processing|cation transport|protein targeting|calcium ion transport into cytosol|cytosolic transport|intracellular protein transport|positive regulation of transcription factor import into nucleus|ion homeostasis|poly(A) RNA binding|regulation of protein import into nucleus|regulation of protein localization to nucleus|transcription factor import into nucleus|cellular ion homeostasis|positive regulation of nucleocytoplasmic transport|regulation of protein targeting|nucleocytoplasmic transport|positive regulation of NFAT protein import into nucleus|NFAT protein import into nucleus|metal ion transport|regulation of transcription factor import into nucleus|cellular cation homeostasis|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import|calcium ion transmembrane transport|metal ion homeostasis|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K12841 calcium homeostasis endoplasmic reticulum protein[-] hsa03040 Spliceosome - Homo sapiens (human) 19:16517889-16542530 3037 3083 1761 1289 1593 1136 22.8151872288006 21.0490681958042 11.9275962205634 8.67621006650361 9.81890316218737 7.99809430688632 18.5972838817227 8.83106917852577 1.07443191146446 1.44666751277171e-05 0.000140726008231628 UP ENSG00000260708 CTA-29F11.1 - - - - - - - 22:46761894-46762563 148 125 173 76 80 48 15.6254196163742 11.9939450515546 16.4676158624472 7.18918275146761 6.92997325505144 4.74946101288489 14.695660176792 6.28953900646798 1.22436398763959 1.45295066549939e-05 0.000141291169927749 UP ENSG00000196187 TMEM63A transmembrane protein 63A [Source:HGNC Symbol;Acc:HGNC:29118] GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:0036094|GO:1903561|GO:0097159|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0006810|GO:0031982|GO:0043231|GO:0005774|GO:0005737|GO:0070062|GO:0000166|GO:0016021|GO:0005773|GO:0006811|GO:0000323|GO:0005765|GO:0005764 cell|membrane|extracellular region|binding|small molecule binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|transport|vesicle|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|extracellular exosome|nucleotide binding|integral component of membrane|vacuole|ion transport|lytic vacuole|lysosomal membrane|lysosome - - - - 1:225845536-225882369 769 927 1488 2120 2294 2298 4.18049961217887 4.57995852299962 7.29321178005083 10.3260724818194 10.2320597959122 11.7079428925112 5.35122330507644 10.7553583900809 -1.00711496047468 1.45517892848041e-05 0.00014146177704609 DOWN ENSG00000165197 FIGF c-fos induced growth factor (vascular endothelial growth factor D) [Source:HGNC Symbol;Acc:HGNC:3708] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0042056|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0048520|GO:0050900|GO:0009628|GO:0050795|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0043227|GO:0009605|GO:0005615|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0048856|GO:0048646|GO:0042802|GO:0048514|GO:0008284|GO:0051272|GO:0042127|GO:0050817|GO:0006935|GO:0002685|GO:0006810|GO:0001568|GO:0007275|GO:0051302|GO:0005102|GO:0032940|GO:0031982|GO:2000147|GO:0090287|GO:0001817|GO:0030141|GO:0043231|GO:0005737|GO:0001816|GO:0009611|GO:0050920|GO:0006928|GO:0002687|GO:0001775|GO:0009966|GO:0046983|GO:0001819|GO:0010646|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0001666|GO:0030595|GO:0031983|GO:0051781|GO:0051301|GO:0048869|GO:2000145|GO:0010033|GO:0050878|GO:0050921|GO:0016192|GO:0005126|GO:0030168|GO:0002688|GO:0007166|GO:0070851|GO:0032675|GO:0001944|GO:0072358|GO:0034097|GO:0031410|GO:0032635|GO:0030947|GO:0002690|GO:0007596|GO:0030334|GO:0050927|GO:0032755|GO:0016023|GO:0006887|GO:0042060|GO:0002551|GO:0060326|GO:0007599|GO:0070848|GO:0031988|GO:0060205|GO:0050918|GO:0007399|GO:0046903|GO:0071310|GO:0030154|GO:0034774|GO:0030335|GO:0097531|GO:0008083|GO:0072359|GO:0031091|GO:0042803|GO:0030182|GO:0045055|GO:0070555|GO:0050930|GO:0071363|GO:0007167|GO:0060753|GO:0022008|GO:0031093|GO:0005172|GO:0005161|GO:0060754|GO:0048699|GO:0043185|GO:0002576|GO:0071542|GO:0007169|GO:0048010 locomotion|developmental process|immune system process|behavior|signaling|chemoattractant activity|cell|membrane|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|positive regulation of behavior|leukocyte migration|response to abiotic stimulus|regulation of behavior|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|membrane-bounded organelle|response to external stimulus|extracellular space|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|identical protein binding|blood vessel morphogenesis|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|coagulation|chemotaxis|regulation of leukocyte migration|transport|blood vessel development|multicellular organism development|regulation of cell division|receptor binding|secretion by cell|vesicle|positive regulation of cell motility|regulation of cellular response to growth factor stimulus|regulation of cytokine production|secretory granule|intracellular membrane-bounded organelle|cytoplasm|cytokine production|response to wounding|regulation of chemotaxis|movement of cell or subcellular component|positive regulation of leukocyte migration|cell activation|regulation of signal transduction|protein dimerization activity|positive regulation of cytokine production|regulation of cell communication|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|response to hypoxia|leukocyte chemotaxis|vesicle lumen|positive regulation of cell division|cell division|cellular developmental process|regulation of cell motility|response to organic substance|regulation of body fluid levels|positive regulation of chemotaxis|vesicle-mediated transport|cytokine receptor binding|platelet activation|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|growth factor receptor binding|regulation of interleukin-6 production|vasculature development|cardiovascular system development|response to cytokine|cytoplasmic vesicle|interleukin-6 production|regulation of vascular endothelial growth factor receptor signaling pathway|positive regulation of leukocyte chemotaxis|blood coagulation|regulation of cell migration|positive regulation of positive chemotaxis|positive regulation of interleukin-6 production|cytoplasmic, membrane-bounded vesicle|exocytosis|wound healing|mast cell chemotaxis|cell chemotaxis|hemostasis|response to growth factor|membrane-bounded vesicle|cytoplasmic membrane-bounded vesicle lumen|positive chemotaxis|nervous system development|secretion|cellular response to organic substance|cell differentiation|secretory granule lumen|positive regulation of cell migration|mast cell migration|growth factor activity|circulatory system development|platelet alpha granule|protein homodimerization activity|neuron differentiation|regulated exocytosis|response to interleukin-1|induction of positive chemotaxis|cellular response to growth factor stimulus|enzyme linked receptor protein signaling pathway|regulation of mast cell chemotaxis|neurogenesis|platelet alpha granule lumen|vascular endothelial growth factor receptor binding|platelet-derived growth factor receptor binding|positive regulation of mast cell chemotaxis|generation of neurons|vascular endothelial growth factor receptor 3 binding|platelet degranulation|dopaminergic neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway K05449 vascular endothelial growth factor C/D[-] hsa05200|hsa04151|hsa04060|hsa04014|hsa04015|hsa04510|hsa04933 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) X:15345591-15384376 75 65 58 16 26 32 2.01185025955007 1.5846435569956 1.40275322997939 0.384539068447975 0.572242920877853 0.804484610955095 1.66641568217502 0.587088866760308 1.50509751779757 1.47359173746421e-05 0.000143205103288595 UP ENSG00000259940 CTD-3203P2.1 - - - - - - - 16:27213308-27214993 22 27 23 8 7 5 0.923015804156897 1.02953000047019 0.870024805306964 0.300739514148682 0.240965734901345 0.196618768469153 0.940856869978017 0.246108005839727 1.93468367722027 1.49148269691798e-05 0.00014489659757172 UP ENSG00000140400 MAN2C1 mannosidase, alpha, class 2C, member 1 [Source:HGNC Symbol;Acc:HGNC:6827] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0016787|GO:0005622|GO:0016798|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0019538|GO:0046872|GO:0043412|GO:0005773|GO:0036211|GO:0005996|GO:0004553|GO:0044267|GO:0019318|GO:0046914|GO:0006464|GO:0015923|GO:0006517|GO:0006013|GO:0008270|GO:0004559 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|hydrolase activity|intracellular|hydrolase activity, acting on glycosyl bonds|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|protein metabolic process|metal ion binding|macromolecule modification|vacuole|protein modification process|monosaccharide metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|cellular protein metabolic process|hexose metabolic process|transition metal ion binding|cellular protein modification process|mannosidase activity|protein deglycosylation|mannose metabolic process|zinc ion binding|alpha-mannosidase activity K01191 alpha-mannosidase[3.2.1.24] hsa00511 Other glycan degradation - Homo sapiens (human) 15:75355207-75368630 147 116 185 302 357 449 0.398128903840148 0.285524429174212 0.451743596439244 0.732842342642761 0.793308123128804 1.13967520722746 0.378465643151201 0.888608557666342 -1.23138569586297 1.50908430261506e-05 0.000146511228521203 DOWN ENSG00000152147 GEMIN6 gem nuclear organelle associated protein 6 [Source:HGNC Symbol;Acc:HGNC:20044] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0034719|GO:0005737|GO:0006139|GO:0022613|GO:0032797|GO:0005829|GO:0022618|GO:0031981|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0034622|GO:0006396|GO:0034660|GO:0016604|GO:0016071|GO:0000387|GO:0000245|GO:0006397|GO:0097504|GO:0008380|GO:0000375|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|SMN-Sm protein complex|cytoplasm|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|SMN complex|cytosol|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|gene expression|RNA metabolic process|nucleus|cellular macromolecular complex assembly|RNA processing|ncRNA metabolic process|nuclear body|mRNA metabolic process|spliceosomal snRNP assembly|spliceosomal complex assembly|mRNA processing|Gemini of coiled bodies|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome K13134 gem associated protein 6[-] hsa03013 RNA transport - Homo sapiens (human) 2:38751534-38785000 511 480 452 290 281 174 6.59849220896481 5.63307153108235 5.26231202457528 3.35520373747017 2.97713294413693 2.10573211892687 5.83129192154081 2.81268960017799 1.05186519760653 1.51457486001489e-05 0.000146996482024982 UP ENSG00000111885 MAN1A1 mannosidase, alpha, class 1A, member 1 [Source:HGNC Symbol;Acc:HGNC:6821] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0006486|GO:0016798|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0005783|GO:0070062|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0009311|GO:0034645|GO:0046872|GO:0043412|GO:0005793|GO:0006487|GO:0009100|GO:0036211|GO:0070085|GO:0004553|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0006491|GO:0018279|GO:0005509|GO:0006464|GO:0015923|GO:0018193|GO:0043687|GO:0004559|GO:0004571 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|protein glycosylation|hydrolase activity, acting on glycosyl bonds|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|endoplasmic reticulum|extracellular exosome|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|oligosaccharide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation|glycoprotein metabolic process|protein modification process|glycosylation|hydrolase activity, hydrolyzing O-glycosyl compounds|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|N-glycan processing|protein N-linked glycosylation via asparagine|calcium ion binding|cellular protein modification process|mannosidase activity|peptidyl-amino acid modification|post-translational protein modification|alpha-mannosidase activity|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase[3.2.1.113] hsa01100|hsa04141|hsa00510 Metabolic pathways - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 6:119177209-119349761 138 209 464 641 658 1411 1.94688781681074 2.67971211790654 5.90191765979861 8.10246270032351 7.61649327630771 18.6559559284558 3.50950586483863 11.4583039683623 -1.70705369569445 1.52863796313132e-05 0.000148313154862927 DOWN ENSG00000023839 ABCC2 ATP binding cassette subfamily C member 2 [Source:HGNC Symbol;Acc:HGNC:53] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0006950|GO:0043167|GO:0009628|GO:0009986|GO:0045177|GO:0005911|GO:0071944|GO:0016787|GO:0031224|GO:0005515|GO:0005886|GO:0006810|GO:0016324|GO:0046685|GO:0043168|GO:0001882|GO:0016817|GO:0005887|GO:0010243|GO:0009408|GO:0042592|GO:0019725|GO:0022891|GO:0006979|GO:0019904|GO:0042493|GO:0031226|GO:0055085|GO:0009725|GO:0000166|GO:0010817|GO:0016021|GO:0010876|GO:0009266|GO:0010033|GO:0046581|GO:0016820|GO:0006855|GO:0031427|GO:0033993|GO:0035639|GO:0048878|GO:0001883|GO:0016818|GO:0006811|GO:0032549|GO:0055082|GO:0015075|GO:0006869|GO:0015893|GO:0009914|GO:0014070|GO:0017076|GO:0048545|GO:0006820|GO:0015711|GO:0070327|GO:0005524|GO:0008509|GO:0030554|GO:0043627|GO:0015908|GO:0046942|GO:0050801|GO:0042626|GO:0016462|GO:0006873|GO:0015732|GO:0015718|GO:0017111|GO:0055081|GO:0008514|GO:0016887|GO:0042623|GO:0055064|GO:0030644|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|response to stress|ion binding|response to abiotic stimulus|cell surface|apical part of cell|cell-cell junction|cell periphery|hydrolase activity|intrinsic component of membrane|protein binding|plasma membrane|transport|apical plasma membrane|response to arsenic-containing substance|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|integral component of plasma membrane|response to organonitrogen compound|response to heat|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|response to oxidative stress|protein domain specific binding|response to drug|intrinsic component of plasma membrane|transmembrane transport|response to hormone|nucleotide binding|regulation of hormone levels|integral component of membrane|lipid localization|response to temperature stimulus|response to organic substance|intercellular canaliculus|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|drug transmembrane transport|response to methotrexate|response to lipid|purine ribonucleoside triphosphate binding|chemical homeostasis|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|ribonucleoside binding|cellular chemical homeostasis|ion transmembrane transporter activity|lipid transport|drug transport|hormone transport|response to organic cyclic compound|purine nucleotide binding|response to steroid hormone|anion transport|organic anion transport|thyroid hormone transport|ATP binding|anion transmembrane transporter activity|adenyl nucleotide binding|response to estrogen|fatty acid transport|carboxylic acid transport|ion homeostasis|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|cellular ion homeostasis|prostaglandin transport|monocarboxylic acid transport|nucleoside-triphosphatase activity|anion homeostasis|organic anion transmembrane transporter activity|ATPase activity|ATPase activity, coupled|chloride ion homeostasis|cellular chloride ion homeostasis|ATPase activity, coupled to movement of substances K05666 ATP-binding cassette, subfamily C (CFTR/MRP), member 2[-] hsa04976|hsa02010 Bile secretion - Homo sapiens (human)|ABC transporters - Homo sapiens (human) 10:99782732-99852192 2460 3073 2247 5976 6603 4570 25.9371961079522 29.4462890312865 21.3601994787573 56.4541981896329 57.1211835234858 45.1578275308747 25.5812282059987 52.9110697479978 -1.04848405366937 1.53059385524366e-05 0.000148454674965706 DOWN ENSG00000196440 ARMCX4 armadillo repeat containing, X-linked 4 [Source:HGNC Symbol;Acc:HGNC:28615] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - X:101418287-101533459 23 11 35 108 60 93 0.0991632436905676 0.0431029894269296 0.136051590522832 0.417192394020233 0.212243706953671 0.375775583859463 0.0927726078801097 0.335070561611122 -1.85269413888232 1.5358574875372e-05 0.000148916821802324 DOWN ENSG00000140287 HDC histidine decarboxylase [Source:HGNC Symbol;Acc:HGNC:4855] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0006807|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0048037|GO:0009058|GO:0005622|GO:0005515|GO:0016830|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0046483|GO:0005737|GO:0006520|GO:0030170|GO:0044249|GO:0005829|GO:0009308|GO:0001692|GO:0009063|GO:0016831|GO:0018958|GO:0019439|GO:0006584|GO:0042423|GO:0046395|GO:0006547|GO:0009309|GO:0006576|GO:0019752|GO:0004398|GO:0001694|GO:0009712|GO:0006548 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cofactor binding|biosynthetic process|intracellular|protein binding|carbon-carbon lyase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|heterocycle metabolic process|cytoplasm|cellular amino acid metabolic process|pyridoxal phosphate binding|cellular biosynthetic process|cytosol|amine metabolic process|histamine metabolic process|cellular amino acid catabolic process|carboxy-lyase activity|phenol-containing compound metabolic process|aromatic compound catabolic process|catecholamine metabolic process|catecholamine biosynthetic process|carboxylic acid catabolic process|histidine metabolic process|amine biosynthetic process|cellular biogenic amine metabolic process|carboxylic acid metabolic process|histidine decarboxylase activity|histamine biosynthetic process|catechol-containing compound metabolic process|histidine catabolic process K01590 histidine decarboxylase[4.1.1.22] hsa01100|hsa00340 Metabolic pathways - Homo sapiens (human)|Histidine metabolism - Homo sapiens (human) 15:50241947-50266026 9 14 6 0 2 0 0.0884092760738695 0.124985728247045 0.0531409959700432 0 0.0161183632578491 0 0.0888453334303192 0.00537278775261637 4.04755324934774 1.53901999166365e-05 0.000149175009191969 UP ENSG00000083635 NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:8057] GO:0032991|GO:0045202|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0060090|GO:0097159|GO:0048786|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0042802|GO:0008023|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0030529|GO:0030674|GO:0006139|GO:0000790|GO:0044249|GO:0022613|GO:0031323|GO:0005730|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0003723|GO:0005726|GO:0051252|GO:0005840|GO:0051117|GO:0010628|GO:0022618|GO:0031981|GO:0005654|GO:0016363|GO:0005694|GO:0000228|GO:0006461|GO:0010467|GO:0031328|GO:0009059|GO:0034399|GO:0016070|GO:0010557|GO:0005634|GO:0070761|GO:0045893|GO:0034622|GO:0006396|GO:0051259|GO:0030515|GO:0032774|GO:0022626|GO:2001141|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0000492|GO:1903506 macromolecular complex|synapse|cell|cellular process|metabolic process|binding|binding, bridging|organic cyclic compound binding|presynaptic active zone|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|identical protein binding|transcription elongation factor complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|intracellular ribonucleoprotein complex|protein binding, bridging|nucleobase-containing compound metabolic process|nuclear chromatin|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|nucleolus|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|RNA binding|perichromatin fibrils|regulation of RNA metabolic process|ribosome|ATPase binding|positive regulation of gene expression|ribonucleoprotein complex assembly|nuclear lumen|nucleoplasm|nuclear matrix|chromosome|nuclear chromosome|protein complex assembly|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|nuclear periphery|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|pre-snoRNP complex|positive regulation of transcription, DNA-templated|cellular macromolecular complex assembly|RNA processing|protein oligomerization|snoRNA binding|RNA biosynthetic process|cytosolic ribosome|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|box C/D snoRNP assembly|regulation of nucleic acid-templated transcription - - - - 13:44939249-44989483 94 105 128 308 340 192 1.90414840259794 1.93304614632307 2.33774066738778 5.59010922702882 5.6509030757121 3.64504152284683 2.0583117387696 4.96201794186258 -1.26946545162366 1.54203060581444e-05 0.000149369830324414 DOWN ENSG00000129473 BCL2L2 BCL2-like 2 [Source:HGNC Symbol;Acc:HGNC:995] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0044702|GO:0019953|GO:0003006|GO:0023051|GO:0043227|GO:0019867|GO:0023057|GO:0032504|GO:0031224|GO:0005622|GO:0005515|GO:0048856|GO:0031090|GO:0048609|GO:0042802|GO:0045137|GO:0010941|GO:0007275|GO:0048513|GO:0031982|GO:0033554|GO:0043231|GO:0048608|GO:0005737|GO:0009966|GO:0046983|GO:0007548|GO:0050673|GO:0031966|GO:0019904|GO:0060548|GO:0010646|GO:0008406|GO:0007154|GO:0007276|GO:0007165|GO:0009968|GO:0070062|GO:0008219|GO:0060011|GO:0016021|GO:0005740|GO:0005829|GO:0008584|GO:0048232|GO:0007166|GO:0046661|GO:0061458|GO:0043069|GO:0005741|GO:2001234|GO:0046982|GO:0051400|GO:0005739|GO:0012501|GO:0035556|GO:1902532|GO:1902531|GO:0042803|GO:0043067|GO:0006974|GO:0097190|GO:0046546|GO:0007283|GO:0097193|GO:2001242|GO:0097192|GO:2001243|GO:0008630|GO:0042981|GO:0043066|GO:0097191|GO:0006915 developmental process|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|single organism reproductive process|sexual reproduction|developmental process involved in reproduction|regulation of signaling|membrane-bounded organelle|outer membrane|negative regulation of signaling|multicellular organism reproduction|intrinsic component of membrane|intracellular|protein binding|anatomical structure development|organelle membrane|multicellular organismal reproductive process|identical protein binding|development of primary sexual characteristics|regulation of cell death|multicellular organism development|animal organ development|vesicle|cellular response to stress|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|regulation of signal transduction|protein dimerization activity|sex differentiation|epithelial cell proliferation|mitochondrial membrane|protein domain specific binding|negative regulation of cell death|regulation of cell communication|gonad development|cell communication|gamete generation|signal transduction|negative regulation of signal transduction|extracellular exosome|cell death|Sertoli cell proliferation|integral component of membrane|mitochondrial envelope|cytosol|male gonad development|male gamete generation|cell surface receptor signaling pathway|male sex differentiation|reproductive system development|negative regulation of programmed cell death|mitochondrial outer membrane|negative regulation of apoptotic signaling pathway|protein heterodimerization activity|BH domain binding|mitochondrion|programmed cell death|intracellular signal transduction|negative regulation of intracellular signal transduction|regulation of intracellular signal transduction|protein homodimerization activity|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|development of primary male sexual characteristics|spermatogenesis|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of apoptotic process|negative regulation of apoptotic process|extrinsic apoptotic signaling pathway|apoptotic process K02163 apoptosis regulator BCL-W[-] hsa05206 MicroRNAs in cancer - Homo sapiens (human) 14:23298790-23311759 161 143 346 678 434 691 2.13709900389779 1.72511064401666 4.14085292844422 8.06356602524993 4.72669770676646 8.59621550563636 2.66768752545289 7.12882641255092 -1.41807490259894 1.55219303289016e-05 0.000150256714668946 DOWN ENSG00000095596 CYP26A1 cytochrome P450 family 26 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:2603] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0042445|GO:0023051|GO:0043227|GO:0008289|GO:0019825|GO:0023057|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0019840|GO:0044255|GO:0006082|GO:0009410|GO:0043168|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0043177|GO:0009966|GO:0010646|GO:0004497|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0009968|GO:0006805|GO:0010817|GO:0055114|GO:0046872|GO:0020037|GO:0042573|GO:0016042|GO:0006720|GO:0044242|GO:0005501|GO:0071466|GO:0008401|GO:0048385|GO:0031406|GO:0048387|GO:0030522|GO:0006766|GO:0046395|GO:0048384|GO:0034653|GO:0046914|GO:0019752|GO:0001972|GO:0005506|GO:0016101|GO:0032787|GO:0001523 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|hormone metabolic process|regulation of signaling|membrane-bounded organelle|lipid binding|oxygen binding|negative regulation of signaling|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|isoprenoid binding|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|organic acid binding|regulation of signal transduction|regulation of cell communication|monooxygenase activity|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|xenobiotic metabolic process|regulation of hormone levels|oxidation-reduction process|metal ion binding|heme binding|retinoic acid metabolic process|lipid catabolic process|isoprenoid metabolic process|cellular lipid catabolic process|retinoid binding|cellular response to xenobiotic stimulus|retinoic acid 4-hydroxylase activity|regulation of retinoic acid receptor signaling pathway|carboxylic acid binding|negative regulation of retinoic acid receptor signaling pathway|intracellular receptor signaling pathway|vitamin metabolic process|carboxylic acid catabolic process|retinoic acid receptor signaling pathway|retinoic acid catabolic process|transition metal ion binding|carboxylic acid metabolic process|retinoic acid binding|iron ion binding|diterpenoid metabolic process|monocarboxylic acid metabolic process|retinoid metabolic process K07437 cytochrome P450, family 26, subfamily A[-] hsa01100|hsa00830 Metabolic pathways - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human) 10:93073475-93077890 176 146 455 64 82 112 2.03028431627807 1.53065004950165 4.7322645225761 0.661488312200478 0.776117158301408 1.21084804306257 2.76439962945194 0.882817837854819 1.6467785053617 1.55284057758504e-05 0.000150270672943999 UP ENSG00000138801 PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [Source:HGNC Symbol;Acc:HGNC:8603] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0016740|GO:0048856|GO:0006725|GO:1901360|GO:0006082|GO:0007275|GO:0009410|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0005737|GO:0005975|GO:0006139|GO:0055086|GO:0006805|GO:0000166|GO:0044249|GO:0006790|GO:0005829|GO:0035639|GO:0019693|GO:0050427|GO:0001883|GO:0009116|GO:0032549|GO:0000103|GO:0071466|GO:0016301|GO:0006796|GO:1901137|GO:0017076|GO:0001501|GO:0016779|GO:0016773|GO:0004020|GO:0009259|GO:0009117|GO:0005524|GO:0046390|GO:0030554|GO:0016310|GO:0006163|GO:0030203|GO:0050428|GO:0009165|GO:0042278|GO:0006164|GO:0004781|GO:0009152 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|transferase activity|anatomical structure development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|response to xenobiotic stimulus|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|cytoplasm|carbohydrate metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|xenobiotic metabolic process|nucleotide binding|cellular biosynthetic process|sulfur compound metabolic process|cytosol|purine ribonucleoside triphosphate binding|ribose phosphate metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|purine nucleoside binding|nucleoside metabolic process|ribonucleoside binding|sulfate assimilation|cellular response to xenobiotic stimulus|kinase activity|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|purine nucleotide binding|skeletal system development|nucleotidyltransferase activity|phosphotransferase activity, alcohol group as acceptor|adenylylsulfate kinase activity|ribonucleotide metabolic process|nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|adenyl nucleotide binding|phosphorylation|purine nucleotide metabolic process|glycosaminoglycan metabolic process|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|nucleotide biosynthetic process|purine nucleoside metabolic process|purine nucleotide biosynthetic process|sulfate adenylyltransferase (ATP) activity|purine ribonucleotide biosynthetic process K13811 3'-phosphoadenosine 5'-phosphosulfate synthase[2.7.1.25] hsa01100|hsa00230|hsa00450|hsa00920 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Selenocompound metabolism - Homo sapiens (human)|Sulfur metabolism - Homo sapiens (human) 4:107590276-107720452 285 287 539 736 842 904 3.95993443802515 3.62413791423116 6.75220367775547 9.16258192169106 9.59892743593832 11.7717264022295 4.77875867667059 10.1777452532863 -1.09071016690209 1.55990167569236e-05 0.000150905070078159 DOWN ENSG00000160207 HSF2BP heat shock transcription factor 2 binding protein [Source:HGNC Symbol;Acc:HGNC:5226] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0009056|GO:0019953|GO:0044237|GO:0006914|GO:0016043|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0048609|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0005737|GO:0006139|GO:0007276|GO:0000422|GO:0016236|GO:0044249|GO:0006996|GO:0005829|GO:0034645|GO:1903008|GO:0048232|GO:0000423|GO:0007005|GO:0010467|GO:0009059|GO:0016070|GO:0007283|GO:0032774|GO:0098779|GO:0006351|GO:0006366 reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|catabolic process|sexual reproduction|cellular metabolic process|autophagy|cellular component organization|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|multicellular organismal reproductive process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|cytoplasm|nucleobase-containing compound metabolic process|gamete generation|mitophagy|macroautophagy|cellular biosynthetic process|organelle organization|cytosol|cellular macromolecule biosynthetic process|organelle disassembly|male gamete generation|macromitophagy|mitochondrion organization|gene expression|macromolecule biosynthetic process|RNA metabolic process|spermatogenesis|RNA biosynthetic process|mitophagy in response to mitochondrial depolarization|transcription, DNA-templated|transcription from RNA polymerase II promoter - - - - 21:43529192-43659493 6 4 3 30 21 19 0.189464900754014 0.114798753712624 0.0854021347380676 0.848822080354016 0.54410923532634 0.562308123070289 0.129888596401569 0.651746479583548 -2.32703611043609 1.57318980470104e-05 0.000152091996209666 DOWN ENSG00000035681 NSMAF neutral sphingomyelinase activation associated factor [Source:HGNC Symbol;Acc:HGNC:8017] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0050794|GO:0006807|GO:0005057|GO:0071704|GO:0043167|GO:0044237|GO:0008289|GO:0009893|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0044255|GO:0010941|GO:0034641|GO:0043168|GO:0008047|GO:0005543|GO:0031325|GO:0010942|GO:0005737|GO:0043085|GO:0007154|GO:0006629|GO:0007165|GO:0008219|GO:0050790|GO:0044249|GO:0010033|GO:0031323|GO:0005829|GO:0006665|GO:0007166|GO:0034097|GO:0060229|GO:0046889|GO:0006643|GO:2000303|GO:0012501|GO:0043603|GO:0035556|GO:0008610|GO:0019216|GO:0071310|GO:0046890|GO:0031328|GO:0009059|GO:0043068|GO:0043067|GO:0006672|GO:0019221|GO:0043065|GO:2000304|GO:0042981|GO:0071345|GO:0034612|GO:0030148|GO:0016004|GO:0006915|GO:0046513|GO:0071356|GO:0033209|GO:0016230 signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|regulation of cellular process|nitrogen compound metabolic process|receptor signaling protein activity|organic substance metabolic process|ion binding|cellular metabolic process|lipid binding|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|intracellular|protein binding|endomembrane system|regulation of metabolic process|cellular lipid metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|enzyme activator activity|phospholipid binding|positive regulation of cellular metabolic process|positive regulation of cell death|cytoplasm|positive regulation of catalytic activity|cell communication|lipid metabolic process|signal transduction|cell death|regulation of catalytic activity|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|cytosol|sphingolipid metabolic process|cell surface receptor signaling pathway|response to cytokine|lipase activator activity|positive regulation of lipid biosynthetic process|membrane lipid metabolic process|regulation of ceramide biosynthetic process|programmed cell death|cellular amide metabolic process|intracellular signal transduction|lipid biosynthetic process|regulation of lipid metabolic process|cellular response to organic substance|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|positive regulation of programmed cell death|regulation of programmed cell death|ceramide metabolic process|cytokine-mediated signaling pathway|positive regulation of apoptotic process|positive regulation of ceramide biosynthetic process|regulation of apoptotic process|cellular response to cytokine stimulus|response to tumor necrosis factor|sphingolipid biosynthetic process|phospholipase activator activity|apoptotic process|ceramide biosynthetic process|cellular response to tumor necrosis factor|tumor necrosis factor-mediated signaling pathway|sphingomyelin phosphodiesterase activator activity K18953 factor associated with neutral sphingomyelinase activation[-] hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) 8:58583504-58659844 238 319 286 683 688 491 1.70140304325923 2.07252953894705 1.84336085220656 4.37470234165711 4.035395506559 3.2895796818578 1.87243114480428 3.89989251002464 -1.05852169332622 1.57631193286796e-05 0.000152344501274976 DOWN ENSG00000104164 BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin [Source:HGNC Symbol;Acc:HGNC:8549] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0044877|GO:0050794|GO:0045321|GO:0043229|GO:0006950|GO:0016079|GO:0051641|GO:0016043|GO:0043473|GO:0043227|GO:0009605|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0007269|GO:0005515|GO:0043234|GO:0016081|GO:0012505|GO:0048856|GO:0042802|GO:0031201|GO:0050817|GO:0045595|GO:0051640|GO:0009888|GO:0048468|GO:0050867|GO:0006810|GO:0007275|GO:0032940|GO:0048066|GO:0031982|GO:0045597|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0043482|GO:0009611|GO:0006928|GO:0032403|GO:0051656|GO:0022406|GO:0002696|GO:0001775|GO:0046983|GO:0045184|GO:0033059|GO:0000149|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0061024|GO:0010970|GO:0051649|GO:0048087|GO:0008092|GO:0001505|GO:0030030|GO:0048869|GO:0048070|GO:0007017|GO:0050878|GO:0005768|GO:0006996|GO:0061025|GO:0016192|GO:0006836|GO:0051650|GO:0051249|GO:0005829|GO:0048278|GO:0031175|GO:0030101|GO:0050942|GO:0016050|GO:0031410|GO:0007596|GO:0003779|GO:0051904|GO:0051875|GO:0015031|GO:0048489|GO:0016023|GO:0006887|GO:0042060|GO:0046907|GO:0051251|GO:0008088|GO:0048753|GO:0031981|GO:0007599|GO:0007018|GO:0009306|GO:0031988|GO:0005654|GO:0051015|GO:0050931|GO:0060429|GO:0031083|GO:0007399|GO:0046903|GO:0051648|GO:0030154|GO:0019905|GO:0072384|GO:0005634|GO:0042803|GO:0048757|GO:0048666|GO:0030182|GO:0045055|GO:0032400|GO:0032438|GO:0006904|GO:0032816|GO:0030855|GO:0047496|GO:0032402|GO:0008089|GO:0033299|GO:0048193|GO:0016482|GO:0016197|GO:0030318|GO:0022008|GO:0030705|GO:0032401|GO:0048699|GO:0017156|GO:0048490|GO:0006892|GO:0035646|GO:0007268|GO:0060563 developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|macromolecular complex binding|regulation of cellular process|leukocyte activation|intracellular organelle|response to stress|synaptic vesicle exocytosis|cellular localization|cellular component organization|pigmentation|membrane-bounded organelle|response to external stimulus|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|neurotransmitter secretion|protein binding|protein complex|synaptic vesicle docking|endomembrane system|anatomical structure development|identical protein binding|SNARE complex|coagulation|regulation of cell differentiation|organelle localization|tissue development|cell development|positive regulation of cell activation|transport|multicellular organism development|secretion by cell|developmental pigmentation|vesicle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|cellular pigment accumulation|response to wounding|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|membrane docking|positive regulation of leukocyte activation|cell activation|protein dimerization activity|establishment of protein localization|cellular pigmentation|SNARE binding|protein localization|lymphocyte activation|regulation of cell activation|cell communication|membrane organization|establishment of localization by movement along microtubule|establishment of localization in cell|positive regulation of developmental pigmentation|cytoskeletal protein binding|regulation of neurotransmitter levels|cell projection organization|cellular developmental process|regulation of developmental pigmentation|microtubule-based process|regulation of body fluid levels|endosome|organelle organization|membrane fusion|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|regulation of lymphocyte activation|cytosol|vesicle docking|neuron projection development|natural killer cell activation|positive regulation of pigment cell differentiation|vesicle organization|cytoplasmic vesicle|blood coagulation|actin binding|pigment granule transport|pigment granule localization|protein transport|synaptic vesicle transport|cytoplasmic, membrane-bounded vesicle|exocytosis|wound healing|intracellular transport|positive regulation of lymphocyte activation|axo-dendritic transport|pigment granule organization|nuclear lumen|hemostasis|microtubule-based movement|protein secretion|membrane-bounded vesicle|nucleoplasm|actin filament binding|pigment cell differentiation|epithelium development|BLOC-1 complex|nervous system development|secretion|vesicle localization|cell differentiation|syntaxin binding|organelle transport along microtubule|nucleus|protein homodimerization activity|pigment granule maturation|neuron development|neuron differentiation|regulated exocytosis|melanosome localization|melanosome organization|vesicle docking involved in exocytosis|positive regulation of natural killer cell activation|epithelial cell differentiation|vesicle transport along microtubule|melanosome transport|anterograde axonal transport|secretion of lysosomal enzymes|Golgi vesicle transport|cytosolic transport|endosomal transport|melanocyte differentiation|neurogenesis|cytoskeleton-dependent intracellular transport|establishment of melanosome localization|generation of neurons|calcium ion regulated exocytosis|anterograde synaptic vesicle transport|post-Golgi vesicle-mediated transport|endosome to melanosome transport|synaptic transmission|neuroepithelial cell differentiation - - - - 15:45587123-45615999 213 336 379 614 773 621 0.825993347290312 1.1841748532738 1.32510539978038 2.13335678616061 2.45948799481989 2.25692646249341 1.1117578667815 2.28325708115797 -1.0382506943698 1.61642027301043e-05 0.000155766981376544 DOWN ENSG00000117697 NSL1 NSL1, MIS12 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:24548] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0022402|GO:0000776|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0000444|GO:0007059|GO:0051301|GO:0006996|GO:0005829|GO:1903047|GO:0000278|GO:0005694|GO:0035556|GO:0007067|GO:0005634|GO:0000777|GO:0000793|GO:0007264|GO:0000775|GO:0000779 macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|cell cycle process|kinetochore|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|MIS12/MIND type complex|chromosome segregation|cell division|organelle organization|cytosol|mitotic cell cycle process|mitotic cell cycle|chromosome|intracellular signal transduction|mitotic nuclear division|nucleus|condensed chromosome kinetochore|condensed chromosome|small GTPase mediated signal transduction|chromosome, centromeric region|condensed chromosome, centromeric region - - - - 1:212726153-212791782 244 296 296 642 650 495 3.45818162507294 3.81267109104479 3.78237550642177 8.15250669026947 7.55857021681582 6.57494168172586 3.68440940751317 7.42867286293705 -1.01167111439063 1.61746876824707e-05 0.000155817723805253 DOWN ENSG00000280053 RP11-61K12.2 - - - - - - - 3:126973065-126976426 0 0 0 5 9 6 0 0 0 0.0942511017037927 0.155364831309768 0.118317962229837 0 0.122644631747799 -Inf 1.62477627335704e-05 0.000156471196338068 DOWN ENSG00000100583 SAMD15 sterile alpha motif domain containing 15 [Source:HGNC Symbol;Acc:HGNC:18631] GO:0005488|GO:0005515 binding|protein binding - - - - 14:77376689-77391497 26 37 16 116 108 65 0.639255786444626 0.826785054425944 0.35469198190734 2.55541273185424 2.1786919971186 1.4977885240024 0.60691094092597 2.07729775099175 -1.77515128698602 1.63541261313704e-05 0.000157444721549801 DOWN ENSG00000139044 B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 [Source:HGNC Symbol;Acc:HGNC:24137] GO:0005623|GO:0016020|GO:0008152|GO:0003824|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0043231|GO:0005737|GO:0016757|GO:0016021|GO:0005794|GO:0008194|GO:0016758|GO:0005795|GO:0000139|GO:0031985|GO:0032580|GO:0008376|GO:0033842 cell|membrane|metabolic process|catalytic activity|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|intracellular membrane-bounded organelle|cytoplasm|transferase activity, transferring glycosyl groups|integral component of membrane|Golgi apparatus|UDP-glycosyltransferase activity|transferase activity, transferring hexosyl groups|Golgi stack|Golgi membrane|Golgi cisterna|Golgi cisterna membrane|acetylgalactosaminyltransferase activity|N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity - - - - 12:460364-563509 46 42 110 180 178 273 0.307928117489674 0.255518755306229 0.663895663346009 1.07960336518955 0.977645421230896 1.71271553176208 0.409114178713971 1.25665477272751 -1.61901292522946 1.63786086009769e-05 0.000157629587741316 DOWN ENSG00000135925 WNT10A wingless-type MMTV integration site family member 10A [Source:HGNC Symbol;Acc:HGNC:13829] GO:0032502|GO:0031012|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0005578|GO:0071704|GO:0009653|GO:0009893|GO:0005615|GO:0050793|GO:0005515|GO:0048856|GO:0019222|GO:0009888|GO:0007275|GO:0048513|GO:0005102|GO:0031069|GO:0001942|GO:0007423|GO:0071559|GO:0009887|GO:0048729|GO:0007154|GO:0007165|GO:0048869|GO:0010033|GO:0048732|GO:0010468|GO:0007166|GO:0002009|GO:0022405|GO:0048733|GO:0010628|GO:0071560|GO:2000027|GO:0060485|GO:0070848|GO:0001664|GO:0043588|GO:0060429|GO:0042476|GO:0010467|GO:0007399|GO:0071310|GO:0043586|GO:0030154|GO:0045165|GO:0042633|GO:0030182|GO:0016055|GO:0048863|GO:0042481|GO:0071363|GO:0008544|GO:0048730|GO:0042475|GO:0005109|GO:0048762|GO:0022008|GO:0098773|GO:0014033|GO:0048699|GO:0042487 developmental process|extracellular matrix|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|proteinaceous extracellular matrix|organic substance metabolic process|anatomical structure morphogenesis|positive regulation of metabolic process|extracellular space|regulation of developmental process|protein binding|anatomical structure development|regulation of metabolic process|tissue development|multicellular organism development|animal organ development|receptor binding|hair follicle morphogenesis|hair follicle development|sensory organ development|response to transforming growth factor beta|organ morphogenesis|tissue morphogenesis|cell communication|signal transduction|cellular developmental process|response to organic substance|gland development|regulation of gene expression|cell surface receptor signaling pathway|morphogenesis of an epithelium|hair cycle process|sebaceous gland development|positive regulation of gene expression|cellular response to transforming growth factor beta stimulus|regulation of organ morphogenesis|mesenchyme development|response to growth factor|G-protein coupled receptor binding|skin development|epithelium development|odontogenesis|gene expression|nervous system development|cellular response to organic substance|tongue development|cell differentiation|cell fate commitment|hair cycle|neuron differentiation|Wnt signaling pathway|stem cell differentiation|regulation of odontogenesis|cellular response to growth factor stimulus|epidermis development|epidermis morphogenesis|odontogenesis of dentin-containing tooth|frizzled binding|mesenchymal cell differentiation|neurogenesis|skin epidermis development|neural crest cell differentiation|generation of neurons|regulation of odontogenesis of dentin-containing tooth K01357 wingless-type MMTV integration site family, member 10[-] hsa05200|hsa05166|hsa05205|hsa04390|hsa04310|hsa04550|hsa04916|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 2:218880363-218899581 51 58 107 192 191 183 0.913773394814757 0.944443647564851 1.72849156351672 3.08225405046606 2.8078294118538 3.07290850370599 1.19556953529878 2.98766398867528 -1.32131986195953 1.64289704017035e-05 0.000158012397671539 DOWN ENSG00000219626 FAM228B family with sequence similarity 228 member B [Source:HGNC Symbol;Acc:HGNC:24736] - - - - - - 2:24076526-24169640 12 13 21 49 59 43 0.0966931331959082 0.0952005184742879 0.152557890164497 0.353749356466207 0.390053239976474 0.324711201161167 0.114817180611564 0.356171265867949 -1.6332325965307 1.64443071199337e-05 0.000158108967716104 DOWN ENSG00000119946 CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 [Source:HGNC Symbol;Acc:HGNC:102] GO:0005623|GO:0016020|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0016021|GO:0006811 cell|membrane|cell periphery|intrinsic component of membrane|plasma membrane|transport|integral component of membrane|ion transport - - - - 10:99329099-99394330 282 334 502 137 160 232 3.03296220232129 3.26470410436509 4.86783961108489 1.32018979400671 1.41190604233237 2.33848211644997 3.72183530592376 1.69019265092968 1.13882651981774 1.65827300084188e-05 0.000159337245468727 UP ENSG00000116574 RHOU ras homolog family member U [Source:HGNC Symbol;Acc:HGNC:17794] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0030055|GO:0050794|GO:0043229|GO:0051050|GO:0043167|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0060341|GO:0007049|GO:0008360|GO:0006810|GO:0022402|GO:0051130|GO:0043168|GO:0005924|GO:0005912|GO:0001882|GO:0051128|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0032880|GO:0051222|GO:0009966|GO:0045184|GO:0032388|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0051649|GO:0090316|GO:0000166|GO:0048869|GO:0030029|GO:0005794|GO:0006996|GO:0002102|GO:0000902|GO:0005829|GO:0046872|GO:0035639|GO:1903047|GO:0072594|GO:0007010|GO:0007005|GO:0032386|GO:0001883|GO:0044770|GO:0051223|GO:1903955|GO:0015031|GO:0016818|GO:0000278|GO:0070201|GO:0046907|GO:0032549|GO:0022604|GO:0030036|GO:0034613|GO:0035556|GO:0033043|GO:0000139|GO:0017076|GO:0006626|GO:1903827|GO:1902531|GO:0005856|GO:0005925|GO:0010638|GO:0015629|GO:0032561|GO:0033365|GO:0033157|GO:0051169|GO:0044772|GO:0006839|GO:0006605|GO:0072655|GO:0010822|GO:0016482|GO:0006886|GO:0010821|GO:0005525|GO:0051056|GO:0007264|GO:1903214|GO:0019001|GO:0016462|GO:1903533|GO:0007265|GO:0006913|GO:0017111|GO:0000082|GO:0070585|GO:0016601|GO:0003924 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|cell-substrate junction|regulation of cellular process|intracellular organelle|positive regulation of transport|ion binding|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of cellular localization|cell cycle|regulation of cell shape|transport|cell cycle process|positive regulation of cellular component organization|anion binding|cell-substrate adherens junction|adherens junction|nucleoside binding|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|regulation of protein localization|positive regulation of protein transport|regulation of signal transduction|establishment of protein localization|positive regulation of intracellular transport|regulation of cell communication|protein localization|cell communication|signal transduction|establishment of localization in cell|positive regulation of intracellular protein transport|nucleotide binding|cellular developmental process|actin filament-based process|Golgi apparatus|organelle organization|podosome|cell morphogenesis|cytosol|metal ion binding|purine ribonucleoside triphosphate binding|mitotic cell cycle process|establishment of protein localization to organelle|cytoskeleton organization|mitochondrion organization|regulation of intracellular transport|purine nucleoside binding|cell cycle phase transition|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|regulation of establishment of protein localization|intracellular transport|ribonucleoside binding|regulation of cell morphogenesis|actin cytoskeleton organization|cellular protein localization|intracellular signal transduction|regulation of organelle organization|Golgi membrane|purine nucleotide binding|protein targeting to mitochondrion|regulation of cellular protein localization|regulation of intracellular signal transduction|cytoskeleton|focal adhesion|positive regulation of organelle organization|actin cytoskeleton|guanyl ribonucleotide binding|protein localization to organelle|regulation of intracellular protein transport|nuclear transport|mitotic cell cycle phase transition|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|GTP binding|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|regulation of protein targeting to mitochondrion|guanyl nucleotide binding|pyrophosphatase activity|regulation of protein targeting|Ras protein signal transduction|nucleocytoplasmic transport|nucleoside-triphosphatase activity|G1/S transition of mitotic cell cycle|protein localization to mitochondrion|Rac protein signal transduction|GTPase activity - - - - 1:228735077-228746669 53 41 85 147 151 270 0.857512463088974 0.602884220013659 1.23992853358561 2.13099194905089 2.00452183841641 4.09410059194802 0.900108405562748 2.74320479313844 -1.60769166056616 1.65988037270898e-05 0.000159409759002163 DOWN ENSG00000197320 AC060834.2 - - - - - - - 7:9726241-9728272 6 7 15 29 36 52 0.208858945713086 0.22147713543866 0.470786124888698 0.904533792565051 1.02822158043984 1.6964969784172 0.300374068680148 1.20975078380736 -2.0098776985984 1.6714192852856e-05 0.000160417286578357 DOWN ENSG00000229544 NKX1-2 NK1 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:31652] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 developmental process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 10:124445239-124450184 114 119 142 63 70 43 2.39715331206427 2.27414368967513 2.69209761894125 1.18693026715234 1.20769390322137 0.847395848690216 2.45446487356022 1.08067333968798 1.18347802147306 1.67166268689378e-05 0.000160417286578357 UP ENSG00000272054 RP11-423P10.2 - - - - - - - 2:37208875-37212677 70 89 91 30 19 45 1.3020110936677 1.50449653160533 1.5260678045797 0.499963570863265 0.289964857562774 0.784436267617492 1.44419180995091 0.52478823201451 1.46045509203963 1.67264322596588e-05 0.000160459803560365 UP ENSG00000136689 IL1RN interleukin 1 receptor antagonist [Source:HGNC Symbol;Acc:HGNC:6000] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0023051|GO:0009653|GO:0007155|GO:0043227|GO:0071944|GO:0023057|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0016337|GO:0019838|GO:0006810|GO:0007275|GO:0005102|GO:0032940|GO:0006952|GO:0030155|GO:0031982|GO:0060761|GO:0098609|GO:0002437|GO:0005737|GO:0007267|GO:0042592|GO:0009966|GO:0048598|GO:0045184|GO:0048871|GO:0010646|GO:0007162|GO:0008104|GO:0007154|GO:0006629|GO:0007165|GO:0009968|GO:0070062|GO:0019955|GO:0009725|GO:0010817|GO:0010033|GO:0030547|GO:0098742|GO:0005126|GO:0007166|GO:0070851|GO:0001959|GO:0033993|GO:0034097|GO:0001659|GO:0015031|GO:0005125|GO:0009790|GO:0070586|GO:0007369|GO:0042886|GO:0006954|GO:0022408|GO:0022407|GO:0009914|GO:0009306|GO:0014070|GO:0034113|GO:0046903|GO:0071310|GO:0001960|GO:0010470|GO:0048019|GO:0019966|GO:0048545|GO:0045995|GO:0002790|GO:0030073|GO:0019221|GO:0070555|GO:0034115|GO:2000660|GO:0002526|GO:0015833|GO:2000659|GO:0071345|GO:0005149|GO:0031649|GO:0031960|GO:0046879|GO:0005152|GO:0051384|GO:0030072|GO:0045352|GO:0071347|GO:0001660|GO:0005151|GO:0045353|GO:0005150|GO:0006953|GO:0070498 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|immune response|regulation of signaling|anatomical structure morphogenesis|cell adhesion|membrane-bounded organelle|cell periphery|negative regulation of signaling|extracellular space|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|single organismal cell-cell adhesion|growth factor binding|transport|multicellular organism development|receptor binding|secretion by cell|defense response|regulation of cell adhesion|vesicle|negative regulation of response to cytokine stimulus|cell-cell adhesion|inflammatory response to antigenic stimulus|cytoplasm|cell-cell signaling|homeostatic process|regulation of signal transduction|embryonic morphogenesis|establishment of protein localization|multicellular organismal homeostasis|regulation of cell communication|negative regulation of cell adhesion|protein localization|cell communication|lipid metabolic process|signal transduction|negative regulation of signal transduction|extracellular exosome|cytokine binding|response to hormone|regulation of hormone levels|response to organic substance|receptor inhibitor activity|cell-cell adhesion via plasma-membrane adhesion molecules|cytokine receptor binding|cell surface receptor signaling pathway|growth factor receptor binding|regulation of cytokine-mediated signaling pathway|response to lipid|response to cytokine|temperature homeostasis|protein transport|cytokine activity|embryo development|cell-cell adhesion involved in gastrulation|gastrulation|amide transport|inflammatory response|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|hormone transport|protein secretion|response to organic cyclic compound|heterotypic cell-cell adhesion|secretion|cellular response to organic substance|negative regulation of cytokine-mediated signaling pathway|regulation of gastrulation|receptor antagonist activity|interleukin-1 binding|response to steroid hormone|regulation of embryonic development|peptide secretion|insulin secretion|cytokine-mediated signaling pathway|response to interleukin-1|negative regulation of heterotypic cell-cell adhesion|negative regulation of interleukin-1-mediated signaling pathway|acute inflammatory response|peptide transport|regulation of interleukin-1-mediated signaling pathway|cellular response to cytokine stimulus|interleukin-1 receptor binding|heat generation|response to corticosteroid|hormone secretion|interleukin-1 receptor antagonist activity|response to glucocorticoid|peptide hormone secretion|interleukin-1 Type I receptor antagonist activity|cellular response to interleukin-1|fever generation|interleukin-1, Type II receptor binding|interleukin-1 Type II receptor antagonist activity|interleukin-1, Type I receptor binding|acute-phase response|interleukin-1-mediated signaling pathway - - - - 2:113107214-113134016 157 141 175 78 91 48 1.90459035156554 1.55454296309495 1.91405569059047 0.847798687823181 0.905760071611675 0.545727813176621 1.79106300175032 0.766428857537159 1.22459229842432 1.68112357380334e-05 0.000161221532837536 UP ENSG00000240602 AADACP1 arylacetamide deacetylase pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:50305] - - - - - - 3:151770428-151784894 16 37 39 84 98 90 0.267186796062214 0.561534608494674 0.587183818152729 1.25679869318649 1.34271841515849 1.40852048353377 0.471968407569872 1.33601253062625 -1.50117134169476 1.68393869487938e-05 0.00016143964610446 DOWN ENSG00000245534 RORA-AS1 RORA antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51410] - - - - - - 15:60479178-60630637 2 1 5 15 19 15 0.047922468122063 0.0217878478106163 0.108013850205521 0.322046317749491 0.373555675240932 0.336865587454802 0.0592413887127334 0.344155860148408 -2.53838471058531 1.71544624685796e-05 0.000164301996322418 DOWN ENSG00000181722 ZBTB20 zinc finger and BTB domain containing 20 [Source:HGNC Symbol;Acc:HGNC:13503] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0001817|GO:0043231|GO:0043169|GO:0000981|GO:0001816|GO:0009890|GO:0001819|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0032479|GO:0046872|GO:0032675|GO:0032635|GO:0010629|GO:0051252|GO:0032481|GO:0032755|GO:0031981|GO:0032606|GO:0005654|GO:0010467|GO:0001227|GO:0009059|GO:0016070|GO:0005634|GO:0032680|GO:0001078|GO:0045892|GO:0032774|GO:0032728|GO:2001141|GO:1902679|GO:0032640|GO:0032608|GO:0032760|GO:0032648|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cytokine production|negative regulation of biosynthetic process|positive regulation of cytokine production|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of type I interferon production|metal ion binding|regulation of interleukin-6 production|interleukin-6 production|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of type I interferon production|positive regulation of interleukin-6 production|nuclear lumen|type I interferon production|nucleoplasm|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulation of tumor necrosis factor production|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|positive regulation of interferon-beta production|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|tumor necrosis factor production|interferon-beta production|positive regulation of tumor necrosis factor production|regulation of interferon-beta production|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 3:114338094-115147271 5 9 10 43 20 54 0.0258610035252814 0.0423057792914744 0.046631609268636 0.199260107097743 0.0848681333294326 0.261742586159186 0.0382661306951306 0.181956942195454 -2.24945716087213 1.76515777223974e-05 0.000168846588056537 DOWN ENSG00000181450 ZNF678 zinc finger protein 678 [Source:HGNC Symbol;Acc:HGNC:28652] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 1:227563543-227677443 41 35 45 63 209 208 0.16079401969546 0.124748350469884 0.159112503039391 0.221369042451653 0.6725056075692 0.764495091053136 0.148218291068245 0.55278991369133 -1.89900779602005 1.77418765942547e-05 0.000169655984575554 DOWN ENSG00000114648 KLHL18 kelch like family member 18 [Source:HGNC Symbol;Acc:HGNC:29120] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0004842|GO:0031461|GO:0036211|GO:1990234|GO:0044267|GO:0006464|GO:0031463|GO:0032446|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|protein complex|transferase activity|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|protein modification process|transferase complex|cellular protein metabolic process|cellular protein modification process|Cul3-RING ubiquitin ligase complex|protein modification by small protein conjugation|protein ubiquitination - - - - 3:47282917-47346816 695 716 565 358 446 256 5.50835991615817 5.15739710228902 4.03738168369904 2.54224939100306 2.90028461665277 1.90154244472917 4.90104623404874 2.44802548412833 1.00147117981211 1.79691442907371e-05 0.000171563007820648 UP ENSG00000277161 PIGW phosphatidylinositol glycan anchor biosynthesis class W [Source:HGNC Symbol;Acc:HGNC:23213] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0019637|GO:0043231|GO:0016746|GO:0005737|GO:0008104|GO:0061024|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0019538|GO:0010256|GO:0008654|GO:0034645|GO:0046486|GO:0043412|GO:0006643|GO:0007009|GO:0036211|GO:0042157|GO:0072657|GO:0034613|GO:0006796|GO:1901137|GO:0044267|GO:0008610|GO:0009059|GO:0006644|GO:0046474|GO:0072659|GO:0009247|GO:0006664|GO:0042158|GO:0006464|GO:1990778|GO:0006650|GO:0016254|GO:0006506|GO:0046488|GO:0006661|GO:0006505|GO:0043687|GO:0006497|GO:0006501 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|organophosphate metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|protein localization|membrane organization|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|protein metabolic process|endomembrane system organization|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|glycerolipid metabolic process|macromolecule modification|membrane lipid metabolic process|plasma membrane organization|protein modification process|lipoprotein metabolic process|protein localization to membrane|cellular protein localization|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|lipid biosynthetic process|macromolecule biosynthetic process|phospholipid metabolic process|glycerophospholipid biosynthetic process|protein localization to plasma membrane|glycolipid biosynthetic process|glycolipid metabolic process|lipoprotein biosynthetic process|cellular protein modification process|protein localization to cell periphery|glycerophospholipid metabolic process|preassembly of GPI anchor in ER membrane|GPI anchor biosynthetic process|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|GPI anchor metabolic process|post-translational protein modification|protein lipidation|C-terminal protein lipidation - - - - 17:36535020-36539310 627 689 304 183 256 62 8.13500205216247 8.12435465097886 3.55612505872542 2.12734395793699 2.72520046097057 0.753890284422475 6.60516058728892 1.86881156777668 1.82147252776197 1.79700383685659e-05 0.000171563007820648 UP ENSG00000206535 LNP1 leukemia NUP98 fusion partner 1 [Source:HGNC Symbol;Acc:HGNC:28014] - - - - - - 3:100401193-100456319 12 24 16 49 60 63 0.158135062654038 0.287424599459327 0.19009851563849 0.578533085025491 0.64871134500538 0.778035688533728 0.211886059250618 0.6684267061882 -1.65748070498916 1.81668529324346e-05 0.000173386581663971 DOWN ENSG00000173281 PPP1R3B protein phosphatase 1 regulatory subunit 3B [Source:HGNC Symbol;Acc:HGNC:14942] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0008287|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0044262|GO:0000164|GO:0019208|GO:0015980|GO:0016788|GO:0044281|GO:0043231|GO:0019899|GO:0005737|GO:0005975|GO:0050790|GO:0006091|GO:0044249|GO:0019538|GO:0031323|GO:0055114|GO:0006109|GO:0005976|GO:0034645|GO:0043412|GO:0042587|GO:0044275|GO:0036211|GO:0033692|GO:0005977|GO:0005996|GO:0016052|GO:0006112|GO:0043467|GO:0006796|GO:0044267|GO:0019888|GO:0009059|GO:0016051|GO:0042578|GO:0005978|GO:0019318|GO:0016311|GO:0000271|GO:0005980|GO:0010906|GO:0005981|GO:0016791|GO:0006464|GO:0070873|GO:0000272|GO:0005979|GO:0006470|GO:0006006|GO:0004721 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|protein serine/threonine phosphatase complex|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|cellular carbohydrate metabolic process|protein phosphatase type 1 complex|phosphatase regulator activity|energy derivation by oxidation of organic compounds|hydrolase activity, acting on ester bonds|small molecule metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|carbohydrate metabolic process|regulation of catalytic activity|generation of precursor metabolites and energy|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|oxidation-reduction process|regulation of carbohydrate metabolic process|polysaccharide metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|glycogen granule|cellular carbohydrate catabolic process|protein modification process|cellular polysaccharide biosynthetic process|glycogen metabolic process|monosaccharide metabolic process|carbohydrate catabolic process|energy reserve metabolic process|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|cellular protein metabolic process|protein phosphatase regulator activity|macromolecule biosynthetic process|carbohydrate biosynthetic process|phosphoric ester hydrolase activity|glycogen biosynthetic process|hexose metabolic process|dephosphorylation|polysaccharide biosynthetic process|glycogen catabolic process|regulation of glucose metabolic process|regulation of glycogen catabolic process|phosphatase activity|cellular protein modification process|regulation of glycogen metabolic process|polysaccharide catabolic process|regulation of glycogen biosynthetic process|protein dephosphorylation|glucose metabolic process|phosphoprotein phosphatase activity K07189 protein phosphatase 1 regulatory subunit 3A/B/C/D/E[-] hsa04910|hsa04931 Insulin signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human) 8:9136255-9151574 462 507 1028 229 230 401 4.14621036334394 4.13520585875997 8.31795254953366 1.84137710738072 1.6935788290861 3.37273511592665 5.53312292387919 2.30256368413116 1.26485291623701 1.82379373854697e-05 0.000174009390446089 UP ENSG00000043039 BARX2 BARX homeobox 2 [Source:HGNC Symbol;Acc:HGNC:956] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0001502|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0061061|GO:0043231|GO:0000981|GO:0009887|GO:0005667|GO:0009890|GO:0003682|GO:0006139|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0051216|GO:0010629|GO:0042692|GO:0051252|GO:0010628|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0051146|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0014902|GO:0000122|GO:0000976|GO:0001012|GO:0000977 developmental process|macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cartilage condensation|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|organ morphogenesis|transcription factor complex|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|negative regulation of gene expression|muscle cell differentiation|regulation of RNA metabolic process|positive regulation of gene expression|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|striated muscle cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 11:129375940-129452279 105 110 174 62 58 61 1.87512965028434 1.78530755584389 2.80159405554486 0.992043581216779 0.849839476437544 1.02093513892795 2.1540104205577 0.954272732194091 1.1745516751909 1.82460404622415e-05 0.000174031083693213 UP ENSG00000109511 ANXA10 annexin A10 [Source:HGNC Symbol;Acc:HGNC:534] GO:0005623|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0043168|GO:0005543|GO:0043231|GO:0043169|GO:0005737|GO:0046872|GO:0005739|GO:0005544|GO:0005509 cell|binding|intracellular organelle|ion binding|membrane-bounded organelle|lipid binding|intracellular|protein binding|anion binding|phospholipid binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|metal ion binding|mitochondrion|calcium-dependent phospholipid binding|calcium ion binding - - - - 4:168092515-168187690 378 426 326 1000 1028 621 10.1320749346099 10.377586788556 7.87840506407681 24.0161942803476 22.6082797268423 15.600074119872 9.4626889290809 20.741516042354 -1.13219924281642 1.82866193584378e-05 0.000174306747869349 DOWN ENSG00000158457 TSPAN33 tetraspanin 33 [Source:HGNC Symbol;Acc:HGNC:28743] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0071704|GO:0009986|GO:0051641|GO:0023051|GO:0016043|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0005887|GO:0019899|GO:0009966|GO:0045184|GO:0010646|GO:0031226|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0016021|GO:0009967|GO:0097197|GO:0019538|GO:0010256|GO:0090150|GO:0007166|GO:0051604|GO:0007009|GO:0072657|GO:0045747|GO:0008593|GO:0034613|GO:0010467|GO:0072659|GO:0090002|GO:0007219|GO:1990778 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|cell surface|cellular localization|regulation of signaling|cellular component organization|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|integral component of plasma membrane|enzyme binding|regulation of signal transduction|establishment of protein localization|regulation of cell communication|intrinsic component of plasma membrane|protein localization|cell communication|membrane organization|signal transduction|integral component of membrane|positive regulation of signal transduction|tetraspanin-enriched microdomain|protein metabolic process|endomembrane system organization|establishment of protein localization to membrane|cell surface receptor signaling pathway|protein maturation|plasma membrane organization|protein localization to membrane|positive regulation of Notch signaling pathway|regulation of Notch signaling pathway|cellular protein localization|gene expression|protein localization to plasma membrane|establishment of protein localization to plasma membrane|Notch signaling pathway|protein localization to cell periphery - - - - 7:129144892-129169697 45 65 72 149 143 166 0.745649094645039 0.978848690512389 1.07563510120775 2.21210084480304 1.94411759684435 2.57785056634089 0.933377628788393 2.24468966932943 -1.2659832103809 1.82828779147496e-05 0.000174306747869349 DOWN ENSG00000213412 HNRNPA1P33 heterogeneous nuclear ribonucleoprotein A1 pseudogene 33 [Source:HGNC Symbol;Acc:HGNC:44990] - - - - - - 10:46415853-46416413 36 40 40 134 168 71 4.53928839221344 4.5837648541226 4.5473357068 15.1386413127766 17.3804589965205 8.39011061643708 4.55679631771201 13.6364036419114 -1.58137141875049 1.84118242352139e-05 0.000175388194230401 DOWN ENSG00000126709 IFI6 interferon, alpha-inducible protein 6 [Source:HGNC Symbol;Acc:HGNC:4054] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0042391|GO:0045087|GO:0010941|GO:0006952|GO:0043231|GO:0005737|GO:0051902|GO:0003254|GO:0042592|GO:0009966|GO:0060548|GO:0010646|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:2000021|GO:0008219|GO:0050790|GO:0043086|GO:0016021|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0032268|GO:0034340|GO:0007166|GO:0051899|GO:0051900|GO:0034097|GO:0007005|GO:0043069|GO:2001234|GO:0048878|GO:0032269|GO:0051346|GO:0006508|GO:0005739|GO:0051881|GO:0012501|GO:0044267|GO:0071310|GO:0051246|GO:0043067|GO:0097190|GO:2001237|GO:0010466|GO:0019221|GO:2001240|GO:0030162|GO:0097192|GO:0008637|GO:2001236|GO:0071357|GO:0051882|GO:0052547|GO:0001836|GO:0042981|GO:0071345|GO:0045861|GO:0050801|GO:0043066|GO:0097191|GO:0006915|GO:0043281|GO:2001239|GO:0010951|GO:0043154|GO:0060337|GO:0052548|GO:2000117|GO:2000116 immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|intrinsic component of membrane|intracellular|protein binding|plasma membrane|regulation of metabolic process|regulation of membrane potential|innate immune response|regulation of cell death|defense response|intracellular membrane-bounded organelle|cytoplasm|negative regulation of mitochondrial depolarization|regulation of membrane depolarization|homeostatic process|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|regulation of ion homeostasis|cell death|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|response to type I interferon|cell surface receptor signaling pathway|membrane depolarization|regulation of mitochondrial depolarization|response to cytokine|mitochondrion organization|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|chemical homeostasis|negative regulation of cellular protein metabolic process|negative regulation of hydrolase activity|proteolysis|mitochondrion|regulation of mitochondrial membrane potential|programmed cell death|cellular protein metabolic process|cellular response to organic substance|regulation of protein metabolic process|regulation of programmed cell death|apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|negative regulation of peptidase activity|cytokine-mediated signaling pathway|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of proteolysis|extrinsic apoptotic signaling pathway in absence of ligand|apoptotic mitochondrial changes|regulation of extrinsic apoptotic signaling pathway|cellular response to type I interferon|mitochondrial depolarization|regulation of peptidase activity|release of cytochrome c from mitochondria|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of proteolysis|ion homeostasis|negative regulation of apoptotic process|extrinsic apoptotic signaling pathway|apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of endopeptidase activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|type I interferon signaling pathway|regulation of endopeptidase activity|negative regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity - - - - 1:27666061-27672218 132 147 246 60 67 98 4.58835092668308 4.64386429006441 7.70958245752781 1.86865991154103 1.91083573908233 3.19255491303253 5.6472658914251 2.32401685455196 1.28093202794674 1.8605793902211e-05 0.000177122886210653 UP ENSG00000143368 SF3B4 splicing factor 3b subunit 4 [Source:HGNC Symbol;Acc:HGNC:10771] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0000166|GO:0031323|GO:0010468|GO:0003723|GO:0051252|GO:0010628|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0050684|GO:0043484|GO:0005689|GO:0016071|GO:0044822|GO:0033120|GO:0048024|GO:0006397|GO:0008380|GO:0048026|GO:0000375|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|nucleotide binding|regulation of cellular metabolic process|regulation of gene expression|RNA binding|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|regulation of mRNA processing|regulation of RNA splicing|U12-type spliceosomal complex|mRNA metabolic process|poly(A) RNA binding|positive regulation of RNA splicing|regulation of mRNA splicing, via spliceosome|mRNA processing|RNA splicing|positive regulation of mRNA splicing, via spliceosome|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome K12831 splicing factor 3B subunit 4[-] hsa03040 Spliceosome - Homo sapiens (human) 1:149923317-149928344 3677 3698 2621 1898 2169 1265 93.4936749042332 85.4546180211997 60.0855148332913 43.239690438682 45.2497473649202 30.1444913366726 79.6779359195747 39.5446430467583 1.01069800259159 1.93171071887997e-05 0.000183543258438709 UP ENSG00000167772 ANGPTL4 angiopoietin like 4 [Source:HGNC Symbol;Acc:HGNC:16039] GO:0032502|GO:0031012|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0005578|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0009653|GO:0016043|GO:0005615|GO:0030234|GO:0050793|GO:0072562|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0044255|GO:0004857|GO:0001568|GO:0010941|GO:0007275|GO:0044281|GO:0022607|GO:0042592|GO:0060548|GO:0001525|GO:0044092|GO:0006629|GO:0008219|GO:0001666|GO:0050790|GO:0043086|GO:0048869|GO:0001944|GO:0072358|GO:0043069|GO:0048878|GO:0045766|GO:0045765|GO:0051346|GO:0006461|GO:0012501|GO:1901342|GO:0030154|GO:0072359|GO:0043067|GO:0051259|GO:0042981|GO:0060192|GO:0043066|GO:0055088|GO:0006915|GO:0051005|GO:0055090|GO:0051260|GO:1904036|GO:0072577|GO:0070328|GO:2000351|GO:2000352 developmental process|extracellular matrix|cellular process|extracellular region|metabolic process|response to stimulus|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|proteinaceous extracellular matrix|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|extracellular space|enzyme regulator activity|regulation of developmental process|blood microparticle|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|cellular lipid metabolic process|enzyme inhibitor activity|blood vessel development|regulation of cell death|multicellular organism development|small molecule metabolic process|cellular component assembly|homeostatic process|negative regulation of cell death|angiogenesis|negative regulation of molecular function|lipid metabolic process|cell death|response to hypoxia|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|vasculature development|cardiovascular system development|negative regulation of programmed cell death|chemical homeostasis|positive regulation of angiogenesis|regulation of angiogenesis|negative regulation of hydrolase activity|protein complex assembly|programmed cell death|regulation of vasculature development|cell differentiation|circulatory system development|regulation of programmed cell death|protein oligomerization|regulation of apoptotic process|negative regulation of lipase activity|negative regulation of apoptotic process|lipid homeostasis|apoptotic process|negative regulation of lipoprotein lipase activity|acylglycerol homeostasis|protein homooligomerization|negative regulation of epithelial cell apoptotic process|endothelial cell apoptotic process|triglyceride homeostasis|regulation of endothelial cell apoptotic process|negative regulation of endothelial cell apoptotic process K08767 angiopoietin-like 4[-] hsa03320 PPAR signaling pathway - Homo sapiens (human) 19:8363289-8374373 191 160 744 81 90 123 1.68905363196825 1.28590677992888 5.93195014566665 0.641791319617889 0.653009594947284 1.01940297946185 2.96897018585459 0.771401298009008 1.94440912732473 1.96875508297129e-05 0.000186765853978471 UP ENSG00000080839 RBL1 retinoblastoma-like 1 [Source:HGNC Symbol;Acc:HGNC:9893] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0016032|GO:0051726|GO:0007049|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0071559|GO:0005667|GO:0009890|GO:0006139|GO:0007154|GO:0006629|GO:0007165|GO:0008134|GO:0050790|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0007166|GO:0010629|GO:0051252|GO:0006325|GO:0010628|GO:0000278|GO:0071560|GO:0031981|GO:0070848|GO:0005654|GO:0006796|GO:0051174|GO:0010467|GO:0019216|GO:0071310|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0045892|GO:0032774|GO:0043550|GO:2001141|GO:0071363|GO:0016310|GO:1902679|GO:0007179|GO:0007167|GO:0016568|GO:0043549|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006352|GO:0006357|GO:1903506|GO:0042325|GO:0007178|GO:0000122|GO:0006367 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|viral process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|response to transforming growth factor beta|transcription factor complex|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|lipid metabolic process|signal transduction|transcription factor binding|regulation of catalytic activity|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|positive regulation of gene expression|mitotic cell cycle|cellular response to transforming growth factor beta stimulus|nuclear lumen|response to growth factor|nucleoplasm|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|gene expression|regulation of lipid metabolic process|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of lipid kinase activity|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|phosphorylation|negative regulation of RNA biosynthetic process|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|chromatin modification|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|regulation of phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter K04681 retinoblastoma-like protein 1[-] hsa05203|hsa04110|hsa04350 Viral carcinogenesis - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human) 20:36996349-37095995 208 285 311 589 675 473 2.21785404020309 2.76181964383369 2.98982115742009 5.62708349115025 5.9053007698068 4.72672693724497 2.65649828048562 5.41970373273401 -1.02868821005858 1.97352958163027e-05 0.000187099879739569 DOWN ENSG00000146670 CDCA5 cell division cycle associated 5 [Source:HGNC Symbol;Acc:HGNC:14626] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0000785|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0060341|GO:0051726|GO:0007049|GO:0006281|GO:0006725|GO:0051640|GO:0022402|GO:0051130|GO:1901360|GO:0051302|GO:0034641|GO:0046483|GO:0051128|GO:0033554|GO:0043231|GO:0005737|GO:0032880|GO:0051656|GO:0045787|GO:0003682|GO:0006139|GO:0000790|GO:0008104|GO:0051983|GO:0051649|GO:0007059|GO:0051781|GO:0051301|GO:0008278|GO:0006996|GO:0051276|GO:0005829|GO:0000819|GO:0090068|GO:1903047|GO:0007080|GO:0044770|GO:0006302|GO:0000278|GO:0031981|GO:0007062|GO:0007346|GO:0010564|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0034613|GO:0033043|GO:0007067|GO:1903827|GO:0045931|GO:0005634|GO:0030261|GO:0006974|GO:0051303|GO:0010638|GO:0033365|GO:0007063|GO:0071922|GO:0007088|GO:0000793|GO:0044772|GO:0007064|GO:0033044|GO:1901990|GO:0007076|GO:1901989|GO:1901992|GO:0000070|GO:0051310|GO:0045840|GO:1901987|GO:0071103|GO:0010458|GO:0000775|GO:0006323|GO:0034502|GO:0031536|GO:0000082|GO:0007096|GO:0071168 macromolecular complex|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|chromatin|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|regulation of cellular localization|regulation of cell cycle|cell cycle|DNA repair|cellular aromatic compound metabolic process|organelle localization|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell division|cellular nitrogen compound metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|establishment of organelle localization|positive regulation of cell cycle|chromatin binding|nucleobase-containing compound metabolic process|nuclear chromatin|protein localization|regulation of chromosome segregation|establishment of localization in cell|chromosome segregation|positive regulation of cell division|cell division|cohesin complex|organelle organization|chromosome organization|cytosol|sister chromatid segregation|positive regulation of cell cycle process|mitotic cell cycle process|mitotic metaphase plate congression|cell cycle phase transition|double-strand break repair|mitotic cell cycle|nuclear lumen|sister chromatid cohesion|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|cellular protein localization|regulation of organelle organization|mitotic nuclear division|regulation of cellular protein localization|positive regulation of mitotic cell cycle|nucleus|chromosome condensation|cellular response to DNA damage stimulus|establishment of chromosome localization|positive regulation of organelle organization|protein localization to organelle|regulation of sister chromatid cohesion|regulation of cohesin localization to chromatin|regulation of mitotic nuclear division|condensed chromosome|mitotic cell cycle phase transition|mitotic sister chromatid cohesion|regulation of chromosome organization|regulation of mitotic cell cycle phase transition|mitotic chromosome condensation|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|mitotic sister chromatid segregation|metaphase plate congression|positive regulation of mitotic nuclear division|regulation of cell cycle phase transition|DNA conformation change|exit from mitosis|chromosome, centromeric region|DNA packaging|protein localization to chromosome|positive regulation of exit from mitosis|G1/S transition of mitotic cell cycle|regulation of exit from mitosis|protein localization to chromatin K17390 sororin[-] hsa05206 MicroRNAs in cancer - Homo sapiens (human) 11:65066300-65084164 1581 3584 2738 1415 1537 1162 15.6281392545469 32.1975957096092 24.4018680099144 12.5322611547791 12.4657135750149 10.7649101346721 24.0758676580235 11.9209616214887 1.01408717400139 1.98677378311116e-05 0.000188295696892065 UP ENSG00000154719 MRPL39 mitochondrial ribosomal protein L39 [Source:HGNC Symbol;Acc:HGNC:14027] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0031090|GO:0019866|GO:0003676|GO:0034641|GO:0005761|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0031966|GO:0000166|GO:0044249|GO:0019538|GO:0006996|GO:0005740|GO:0034645|GO:0006518|GO:0003723|GO:0007005|GO:0005840|GO:0005743|GO:0005759|GO:0005739|GO:0070124|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0032543|GO:0043241|GO:0043043|GO:0070125|GO:0006412|GO:0044822|GO:0070126|GO:0006414|GO:0043624|GO:0006415 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|organelle membrane|organelle inner membrane|nucleic acid binding|cellular nitrogen compound metabolic process|mitochondrial ribosome|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|mitochondrial membrane|nucleotide binding|cellular biosynthetic process|protein metabolic process|organelle organization|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|mitochondrion organization|ribosome|mitochondrial inner membrane|mitochondrial matrix|mitochondrion|mitochondrial translational initiation|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|mitochondrial translation|protein complex disassembly|peptide biosynthetic process|mitochondrial translational elongation|translation|poly(A) RNA binding|mitochondrial translational termination|translational elongation|cellular protein complex disassembly|translational termination - - - - 21:25585656-25607517 114 115 116 370 341 200 6.11374051689477 5.60505698540626 5.60883531960391 17.7787308915726 15.0045616133215 10.0521921740358 5.77587760730165 14.2784948929766 -1.30573183530726 2.00958228824445e-05 0.000190155529740887 DOWN ENSG00000178401 DNAJC22 DnaJ heat shock protein family (Hsp40) member C22 [Source:HGNC Symbol;Acc:HGNC:25802] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 12:49346917-49357546 134 118 175 75 74 46 1.46457992300624 1.17211088463075 1.72448373483205 0.734456682630175 0.663599962619935 0.471183076502942 1.45372484748968 0.623079907251017 1.22226513073787 2.01094795989325e-05 0.000190224462593958 UP ENSG00000152464 RPP38 ribonuclease P/MRP 38kDa subunit [Source:HGNC Symbol;Acc:HGNC:30329] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0006725|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0005730|GO:0030677|GO:0031981|GO:0004518|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0090501|GO:0006396|GO:0034660|GO:0005655|GO:0004519|GO:0004540|GO:0090305|GO:0006399|GO:0090502|GO:0004521|GO:0008033|GO:0004526|GO:0016891 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|nucleolus|ribonuclease P complex|nuclear lumen|nuclease activity|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA phosphodiester bond hydrolysis|RNA processing|ncRNA metabolic process|nucleolar ribonuclease P complex|endonuclease activity|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|tRNA metabolic process|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|tRNA processing|ribonuclease P activity|endoribonuclease activity, producing 5'-phosphomonoesters K14523 ribonucleases P/MRP protein subunit RPP38[3.1.26.5] hsa03013|hsa03008 RNA transport - Homo sapiens (human)|Ribosome biogenesis in eukaryotes - Homo sapiens (human) 10:15097180-15139818 462 333 371 214 223 171 4.602229275296 3.01474468623969 3.33206917073936 1.91002022678191 1.82263344624884 1.596433290325 3.64968104409168 1.77636232111858 1.03884451295373 2.02020191495691e-05 0.000190918353811724 UP ENSG00000229994 RPL5P4 ribosomal protein L5 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:36095] - - - - - - 1:35350722-35351607 260 276 224 142 139 105 20.7579997278314 20.0262927469788 16.1240216220558 10.1577432044134 9.10530626782053 7.8564892388998 18.9694380322887 9.03984623704458 1.0693068011958 2.02295492032707e-05 0.000191118025922292 UP ENSG00000267284 RP11-397A16.1 - - - - - - - 18:55721063-55788761 2 2 3 30 11 16 0.0866302056927925 0.0787352138139247 0.117146835158158 1.16433647274525 0.390939924484514 0.64954865863092 0.0941707515549584 0.734941685286895 -2.96427883373557 2.02820140277147e-05 0.00019155306763157 DOWN ENSG00000215837 SDHAP2 succinate dehydrogenase complex subunit A, flavoprotein pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:27408] - - - - - - 3:195658096-195685904 52 63 80 168 173 139 1.83825290162483 2.02405320121901 2.54978044129416 5.32113869499049 5.01778074508894 4.60512087731596 2.13736218137933 4.98134677246513 -1.22070444956196 2.05642154135428e-05 0.000193911587794033 DOWN ENSG00000232774 FLJ22447 uncharacterized LOC400221 [Source:EntrezGene;Acc:400221] - - - - - - 14:61570540-61658696 1 1 1 6 15 14 0.02061966591568 0.0187405963685721 0.0185736240733813 0.110805686375585 0.253671237083825 0.270437490905844 0.0193112954525445 0.211638138121751 -3.45408277843114 2.06428954670511e-05 0.000194592043344914 DOWN ENSG00000133119 RFC3 replication factor C subunit 3 [Source:HGNC Symbol;Acc:HGNC:9971] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0051606|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0042769|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0000723|GO:0005663|GO:0042592|GO:0019725|GO:0006139|GO:0044249|GO:0010033|GO:0006996|GO:0051276|GO:0003677|GO:0034645|GO:0000725|GO:0010833|GO:0019985|GO:0046683|GO:0000722|GO:0006284|GO:0006302|GO:0016818|GO:0033260|GO:0000278|GO:0005657|GO:0031981|GO:0000731|GO:0005654|GO:0006259|GO:0005694|GO:0032201|GO:0006301|GO:0009059|GO:0006289|GO:0005634|GO:0006974|GO:0000724|GO:0032200|GO:0006260|GO:0006297|GO:0070987|GO:0022616|GO:0006283|GO:0070911|GO:0006310|GO:0033683|GO:0090305|GO:0042276|GO:0016462|GO:0071897|GO:0003689|GO:0006271|GO:0006261|GO:0017111|GO:0006312|GO:0016887|GO:0042623|GO:0008094 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|detection of stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|DNA damage response, detection of DNA damage|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|telomere maintenance|DNA replication factor C complex|homeostatic process|cellular homeostasis|nucleobase-containing compound metabolic process|cellular biosynthetic process|response to organic substance|organelle organization|chromosome organization|DNA binding|cellular macromolecule biosynthetic process|recombinational repair|telomere maintenance via telomere lengthening|translesion synthesis|response to organophosphorus|telomere maintenance via recombination|base-excision repair|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nuclear DNA replication|mitotic cell cycle|replication fork|nuclear lumen|DNA synthesis involved in DNA repair|nucleoplasm|DNA metabolic process|chromosome|telomere maintenance via semi-conservative replication|postreplication repair|macromolecule biosynthetic process|nucleotide-excision repair|nucleus|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|telomere organization|DNA replication|nucleotide-excision repair, DNA gap filling|error-free translesion synthesis|DNA strand elongation|transcription-coupled nucleotide-excision repair|global genome nucleotide-excision repair|DNA recombination|nucleotide-excision repair, DNA incision|nucleic acid phosphodiester bond hydrolysis|error-prone translesion synthesis|pyrophosphatase activity|DNA biosynthetic process|DNA clamp loader activity|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication|nucleoside-triphosphatase activity|mitotic recombination|ATPase activity|ATPase activity, coupled|DNA-dependent ATPase activity K10756 replication factor C subunit 3/5[-] hsa03420|hsa03030|hsa03430 Nucleotide excision repair - Homo sapiens (human)|DNA replication - Homo sapiens (human)|Mismatch repair - Homo sapiens (human) 13:33818049-33966558 449 518 518 1170 1501 725 9.03837809763128 9.47663156695325 9.40129857874189 21.1021903641795 24.7909220521779 13.6776408194024 9.30543608110881 19.8569177452533 -1.09349603440258 2.09494726336165e-05 0.000197232909493531 DOWN ENSG00000137822 TUBGCP4 tubulin gamma complex associated protein 4 [Source:HGNC Symbol;Acc:HGNC:16691] GO:0032991|GO:0000003|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0005488|GO:0005200|GO:0044877|GO:0050794|GO:0043229|GO:0044089|GO:0044702|GO:0051321|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0007049|GO:0000930|GO:0022402|GO:0051130|GO:0005874|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0032886|GO:0032403|GO:0007126|GO:0008092|GO:0000923|GO:0007017|GO:0031334|GO:0043254|GO:0005768|GO:0006996|GO:0031023|GO:0015631|GO:0005829|GO:0005813|GO:1903047|GO:0007010|GO:0070507|GO:0005815|GO:0044770|GO:0007098|GO:0051415|GO:0008017|GO:0000278|GO:0055037|GO:0007051|GO:0006461|GO:0070925|GO:0032273|GO:0033043|GO:0007067|GO:0051298|GO:0000226|GO:0005856|GO:0000922|GO:0005819|GO:0010638|GO:0008274|GO:0051225|GO:0034622|GO:0031113|GO:0000086|GO:0031122|GO:0044772|GO:0043623|GO:0031116|GO:0007052|GO:0031110|GO:0051493|GO:0015630|GO:0007020|GO:0031109|GO:0051297|GO:0005816|GO:0043015|GO:0051495|GO:0090307|GO:0051011|GO:0051258|GO:0010968|GO:0090063|GO:0046785 macromolecular complex|reproduction|structural molecule activity|cell|membrane|cellular process|reproductive process|binding|structural constituent of cytoskeleton|macromolecular complex binding|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|single organism reproductive process|meiotic cell cycle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|cell cycle|gamma-tubulin complex|cell cycle process|positive regulation of cellular component organization|microtubule|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|regulation of microtubule-based process|protein complex binding|meiotic nuclear division|cytoskeletal protein binding|equatorial microtubule organizing center|microtubule-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|endosome|organelle organization|microtubule organizing center organization|tubulin binding|cytosol|centrosome|mitotic cell cycle process|cytoskeleton organization|regulation of microtubule cytoskeleton organization|microtubule organizing center|cell cycle phase transition|centrosome cycle|interphase microtubule nucleation by interphase microtubule organizing center|microtubule binding|mitotic cell cycle|recycling endosome|spindle organization|protein complex assembly|organelle assembly|positive regulation of protein polymerization|regulation of organelle organization|mitotic nuclear division|centrosome duplication|microtubule cytoskeleton organization|cytoskeleton|spindle pole|spindle|positive regulation of organelle organization|gamma-tubulin ring complex|spindle assembly|cellular macromolecular complex assembly|regulation of microtubule polymerization|G2/M transition of mitotic cell cycle|cytoplasmic microtubule organization|mitotic cell cycle phase transition|cellular protein complex assembly|positive regulation of microtubule polymerization|mitotic spindle organization|regulation of microtubule polymerization or depolymerization|regulation of cytoskeleton organization|microtubule cytoskeleton|microtubule nucleation|microtubule polymerization or depolymerization|centrosome organization|spindle pole body|gamma-tubulin binding|positive regulation of cytoskeleton organization|mitotic spindle assembly|microtubule minus-end binding|protein polymerization|regulation of microtubule nucleation|positive regulation of microtubule nucleation|microtubule polymerization - - - - 15:43369221-43409771 194 197 278 497 529 420 0.919215876578002 0.848323995862721 1.18761010225803 2.10993541396598 2.05654737253437 1.86506389551622 0.985049991566251 2.01051556067219 -1.02929665340388 2.09456327480952e-05 0.000197232909493531 DOWN ENSG00000280077 RP11-87H9.4 - - - - - - - 9:41012231-41014133 16 17 30 54 73 66 0.594746856605118 0.574311382029454 1.00539927038763 1.79844340743299 2.22638667989532 2.29922402991729 0.724819169674067 2.10801803908187 -1.540194195981 2.10069540442995e-05 0.000197711729520339 DOWN ENSG00000147162 OGT O-linked N-acetylglucosamine (GlcNAc) transferase [Source:HGNC Symbol;Acc:HGNC:8127] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0032259|GO:0033218|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0044297|GO:0000785|GO:0016043|GO:0051707|GO:0030246|GO:0043227|GO:0008289|GO:0071944|GO:1903828|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:1900038|GO:0060341|GO:0006486|GO:0044262|GO:1903409|GO:0048029|GO:1903706|GO:0000791|GO:0042277|GO:0045595|GO:0006725|GO:0051640|GO:0043025|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0006082|GO:0009991|GO:0007275|GO:0016570|GO:0048513|GO:0032535|GO:0034641|GO:0043168|GO:0008047|GO:0044281|GO:0030900|GO:0005543|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0007420|GO:0022607|GO:0032922|GO:1900076|GO:0030141|GO:0045597|GO:0043231|GO:0016746|GO:0010243|GO:0005737|GO:0060322|GO:0032880|GO:0005975|GO:0042592|GO:0072593|GO:0043005|GO:0009966|GO:0045184|GO:0019725|GO:0036477|GO:0051186|GO:0019904|GO:0060548|GO:0032387|GO:0010646|GO:0006139|GO:0043085|GO:0009617|GO:0055086|GO:1900182|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0016757|GO:0051649|GO:0008134|GO:0009725|GO:0008219|GO:0001666|GO:0090317|GO:0050790|GO:0006091|GO:0048869|GO:0044249|GO:0019538|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:0006996|GO:0009636|GO:0007584|GO:0051276|GO:0032268|GO:0051646|GO:0006109|GO:0005829|GO:0009743|GO:0010468|GO:0034645|GO:0090150|GO:0007166|GO:0033993|GO:0043412|GO:0030097|GO:0007417|GO:0031410|GO:0002237|GO:0019693|GO:0007005|GO:0031056|GO:0048878|GO:0035091|GO:0051252|GO:0008194|GO:0016571|GO:0006479|GO:0006325|GO:0032386|GO:0051223|GO:0015031|GO:1901652|GO:0031058|GO:0071417|GO:0016573|GO:0010628|GO:0090315|GO:0044275|GO:0016023|GO:0006493|GO:0009100|GO:0036211|GO:0032269|GO:2000377|GO:0009116|GO:0071456|GO:0070201|GO:0071219|GO:0046907|GO:0042588|GO:0055082|GO:0006040|GO:1903428|GO:0016758|GO:0072657|GO:0031981|GO:1900037|GO:0043434|GO:1990234|GO:0097237|GO:0008361|GO:0005996|GO:0051247|GO:0006508|GO:0031988|GO:0005654|GO:0070085|GO:0005739|GO:0016747|GO:0005694|GO:0016052|GO:0006461|GO:0071453|GO:0034613|GO:0032270|GO:0012501|GO:0043467|GO:0006796|GO:0032526|GO:0035556|GO:1901137|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0045639|GO:0007399|GO:0071310|GO:0031328|GO:0000123|GO:0019439|GO:0051246|GO:0009059|GO:0030154|GO:0046626|GO:0035097|GO:1903827|GO:1902531|GO:0016070|GO:0031667|GO:0046434|GO:0032870|GO:0010557|GO:0032496|GO:0048311|GO:0005634|GO:0016051|GO:1903426|GO:0045637|GO:0006757|GO:2000379|GO:0010638|GO:2001252|GO:0006110|GO:0045793|GO:0002521|GO:0071322|GO:0002761|GO:0031062|GO:0019318|GO:0009101|GO:0045893|GO:0043413|GO:0033365|GO:0033157|GO:0031401|GO:0001678|GO:0051259|GO:0009259|GO:1901653|GO:0009117|GO:0008375|GO:0032774|GO:0030162|GO:2001141|GO:0043967|GO:0034284|GO:0045862|GO:0006111|GO:0097363|GO:0016310|GO:0006605|GO:0033044|GO:0070688|GO:0006886|GO:0048017|GO:0010906|GO:0016407|GO:0007167|GO:0031060|GO:0018022|GO:0009132|GO:1901981|GO:0071375|GO:0002763|GO:0006163|GO:0034968|GO:0016410|GO:0019752|GO:0016568|GO:0032868|GO:0009166|GO:0030099|GO:0006096|GO:0071300|GO:0051056|GO:1900180|GO:0007264|GO:0006464|GO:0048312|GO:0071396|GO:0006612|GO:0042278|GO:0006351|GO:0006915|GO:0006355|GO:0033500|GO:0071222|GO:0036294|GO:0071333|GO:0016262|GO:0042593|GO:1903533|GO:0070734|GO:0045944|GO:0006366|GO:0007265|GO:0019319|GO:0002573|GO:0046578|GO:0048015|GO:0046939|GO:1903578|GO:0006357|GO:0051568|GO:0006468|GO:0051291|GO:1903506|GO:0006006|GO:0030854|GO:0042325|GO:0070206|GO:0051571|GO:0001932|GO:0032869|GO:0018193|GO:0042326|GO:0043984|GO:0008080|GO:0032787|GO:0051569|GO:0005547|GO:0090526|GO:0001934|GO:0006041|GO:0001933|GO:0051260|GO:0043981|GO:0061085|GO:0043982|GO:0030852|GO:0006165|GO:0042327|GO:0018023|GO:0061087|GO:0034504|GO:0007169|GO:0032446|GO:0046034|GO:0033137|GO:0070207|GO:0031396|GO:0030851|GO:0046031|GO:0070208|GO:0031397|GO:0016601|GO:0006094|GO:0009749|GO:0018105|GO:0010801|GO:0033135|GO:0018107|GO:0006473|GO:0006090|GO:0035020|GO:0018205|GO:0080182|GO:0008286|GO:0018394|GO:0016567|GO:0006475|GO:0018393|GO:0004402|GO:0010485|GO:0043995|GO:0043996|GO:0046972 developmental process|macromolecular complex|immune system process|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|methylation|amide binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cell body|chromatin|cellular component organization|response to other organism|carbohydrate binding|membrane-bounded organelle|lipid binding|cell periphery|negative regulation of cellular protein localization|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|negative regulation of cellular response to hypoxia|regulation of cellular localization|protein glycosylation|cellular carbohydrate metabolic process|reactive oxygen species biosynthetic process|monosaccharide binding|regulation of hemopoiesis|euchromatin|peptide binding|regulation of cell differentiation|cellular aromatic compound metabolic process|organelle localization|neuronal cell body|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|histone modification|animal organ development|regulation of cellular component size|cellular nitrogen compound metabolic process|anion binding|enzyme activator activity|small molecule metabolic process|forebrain development|phospholipid binding|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|brain development|cellular component assembly|circadian regulation of gene expression|regulation of cellular response to insulin stimulus|secretory granule|positive regulation of cell differentiation|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|response to organonitrogen compound|cytoplasm|head development|regulation of protein localization|carbohydrate metabolic process|homeostatic process|reactive oxygen species metabolic process|neuron projection|regulation of signal transduction|establishment of protein localization|cellular homeostasis|somatodendritic compartment|cofactor metabolic process|protein domain specific binding|negative regulation of cell death|negative regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|nucleobase-containing small molecule metabolic process|positive regulation of protein localization to nucleus|protein localization|cell communication|membrane organization|signal transduction|transferase activity, transferring glycosyl groups|establishment of localization in cell|transcription factor binding|response to hormone|cell death|response to hypoxia|negative regulation of intracellular protein transport|regulation of catalytic activity|generation of precursor metabolites and energy|cellular developmental process|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|response to toxic substance|response to nutrient|chromosome organization|regulation of cellular protein metabolic process|mitochondrion localization|regulation of carbohydrate metabolic process|cytosol|response to carbohydrate|regulation of gene expression|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|cell surface receptor signaling pathway|response to lipid|macromolecule modification|hemopoiesis|central nervous system development|cytoplasmic vesicle|response to molecule of bacterial origin|ribose phosphate metabolic process|mitochondrion organization|regulation of histone modification|chemical homeostasis|phosphatidylinositol binding|regulation of RNA metabolic process|UDP-glycosyltransferase activity|histone methylation|protein methylation|chromatin organization|regulation of intracellular transport|regulation of protein transport|protein transport|response to peptide|positive regulation of histone modification|cellular response to organonitrogen compound|histone acetylation|positive regulation of gene expression|negative regulation of protein targeting to membrane|cellular carbohydrate catabolic process|cytoplasmic, membrane-bounded vesicle|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|negative regulation of cellular protein metabolic process|regulation of reactive oxygen species metabolic process|nucleoside metabolic process|cellular response to hypoxia|regulation of establishment of protein localization|cellular response to molecule of bacterial origin|intracellular transport|zymogen granule|cellular chemical homeostasis|amino sugar metabolic process|positive regulation of reactive oxygen species biosynthetic process|transferase activity, transferring hexosyl groups|protein localization to membrane|nuclear lumen|regulation of cellular response to hypoxia|response to peptide hormone|transferase complex|cellular response to toxic substance|regulation of cell size|monosaccharide metabolic process|positive regulation of protein metabolic process|proteolysis|membrane-bounded vesicle|nucleoplasm|glycosylation|mitochondrion|transferase activity, transferring acyl groups other than amino-acyl groups|chromosome|carbohydrate catabolic process|protein complex assembly|cellular response to oxygen levels|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|response to retinoic acid|intracellular signal transduction|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|positive regulation of myeloid cell differentiation|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|histone acetyltransferase complex|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|regulation of insulin receptor signaling pathway|histone methyltransferase complex|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|organophosphate catabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|mitochondrion distribution|nucleus|carbohydrate biosynthetic process|regulation of reactive oxygen species biosynthetic process|regulation of myeloid cell differentiation|ATP generation from ADP|positive regulation of reactive oxygen species metabolic process|positive regulation of organelle organization|positive regulation of chromosome organization|regulation of glycolytic process|positive regulation of cell size|leukocyte differentiation|cellular response to carbohydrate stimulus|regulation of myeloid leukocyte differentiation|positive regulation of histone methylation|hexose metabolic process|glycoprotein biosynthetic process|positive regulation of transcription, DNA-templated|macromolecule glycosylation|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|cellular glucose homeostasis|protein oligomerization|ribonucleotide metabolic process|cellular response to peptide|nucleotide metabolic process|acetylglucosaminyltransferase activity|RNA biosynthetic process|regulation of proteolysis|regulation of RNA biosynthetic process|histone H4 acetylation|response to monosaccharide|positive regulation of proteolysis|regulation of gluconeogenesis|protein O-GlcNAc transferase activity|phosphorylation|protein targeting|regulation of chromosome organization|MLL5-L complex|intracellular protein transport|inositol lipid-mediated signaling|regulation of glucose metabolic process|acetyltransferase activity|enzyme linked receptor protein signaling pathway|regulation of histone methylation|peptidyl-lysine methylation|nucleoside diphosphate metabolic process|phosphatidylinositol phosphate binding|cellular response to peptide hormone stimulus|positive regulation of myeloid leukocyte differentiation|purine nucleotide metabolic process|histone lysine methylation|N-acyltransferase activity|carboxylic acid metabolic process|chromatin modification|response to insulin|nucleotide catabolic process|myeloid cell differentiation|glycolytic process|cellular response to retinoic acid|regulation of small GTPase mediated signal transduction|regulation of protein localization to nucleus|small GTPase mediated signal transduction|cellular protein modification process|intracellular distribution of mitochondria|cellular response to lipid|protein targeting to membrane|purine nucleoside metabolic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|carbohydrate homeostasis|cellular response to lipopolysaccharide|cellular response to decreased oxygen levels|cellular response to glucose stimulus|protein N-acetylglucosaminyltransferase activity|glucose homeostasis|regulation of protein targeting|histone H3-K27 methylation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|Ras protein signal transduction|hexose biosynthetic process|myeloid leukocyte differentiation|regulation of Ras protein signal transduction|phosphatidylinositol-mediated signaling|nucleotide phosphorylation|regulation of ATP metabolic process|regulation of transcription from RNA polymerase II promoter|histone H3-K4 methylation|protein phosphorylation|protein heterooligomerization|regulation of nucleic acid-templated transcription|glucose metabolic process|positive regulation of granulocyte differentiation|regulation of phosphorylation|protein trimerization|positive regulation of histone H3-K4 methylation|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|negative regulation of phosphorylation|histone H4-K16 acetylation|N-acetyltransferase activity|monocarboxylic acid metabolic process|regulation of histone H3-K4 methylation|phosphatidylinositol-3,4,5-trisphosphate binding|regulation of gluconeogenesis involved in cellular glucose homeostasis|positive regulation of protein phosphorylation|glucosamine metabolic process|negative regulation of protein phosphorylation|protein homooligomerization|histone H4-K5 acetylation|regulation of histone H3-K27 methylation|histone H4-K8 acetylation|regulation of granulocyte differentiation|nucleoside diphosphate phosphorylation|positive regulation of phosphorylation|peptidyl-lysine trimethylation|positive regulation of histone H3-K27 methylation|protein localization to nucleus|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|ATP metabolic process|negative regulation of peptidyl-serine phosphorylation|protein homotrimerization|regulation of protein ubiquitination|granulocyte differentiation|ADP metabolic process|protein heterotrimerization|negative regulation of protein ubiquitination|Rac protein signal transduction|gluconeogenesis|response to glucose|peptidyl-serine phosphorylation|negative regulation of peptidyl-threonine phosphorylation|regulation of peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein acetylation|pyruvate metabolic process|regulation of Rac protein signal transduction|peptidyl-lysine modification|histone H3-K4 trimethylation|insulin receptor signaling pathway|peptidyl-lysine acetylation|protein ubiquitination|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|histone acetyltransferase activity|H4 histone acetyltransferase activity|histone acetyltransferase activity (H4-K5 specific)|histone acetyltransferase activity (H4-K8 specific)|histone acetyltransferase activity (H4-K16 specific) K09667 protein O-GlcNAc transferase[2.4.1.255] hsa04931 Insulin resistance - Homo sapiens (human) X:71533083-71575897 2052 2639 3703 5282 5325 7686 10.9913698157218 12.8467668604626 17.883084890918 25.3495667623793 23.402486768857 38.5836890554109 13.9070738557008 29.1119141955491 -1.06579080528019 2.10626205452943e-05 0.000198110735273855 DOWN ENSG00000153162 BMP6 bone morphogenetic protein 6 [Source:HGNC Symbol;Acc:HGNC:1073] GO:0032502|GO:0040007|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0014823|GO:0048523|GO:0008283|GO:0050794|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0042445|GO:0003006|GO:0023051|GO:0009653|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0005615|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:0008284|GO:0042127|GO:0045595|GO:0006725|GO:0001822|GO:0046887|GO:0009888|GO:0048468|GO:0006810|GO:0009612|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0031664|GO:0005102|GO:0034641|GO:0044281|GO:0032940|GO:0006952|GO:0061036|GO:0031982|GO:0031325|GO:0046483|GO:0032350|GO:0070169|GO:0045597|GO:0048608|GO:0005737|GO:0007267|GO:0007423|GO:0032880|GO:0051222|GO:0009887|GO:0042592|GO:0031018|GO:0009966|GO:0046983|GO:0007548|GO:0050673|GO:0045184|GO:0009890|GO:0046883|GO:0019725|GO:0048871|GO:0032388|GO:0010646|GO:0006139|GO:0009617|GO:1900182|GO:0008104|GO:0007154|GO:0045778|GO:0006629|GO:0007165|GO:0008207|GO:0030278|GO:0001503|GO:0042180|GO:0051649|GO:0042446|GO:0009725|GO:0008219|GO:0090316|GO:0060348|GO:0031666|GO:0031016|GO:0051047|GO:0010817|GO:0048869|GO:0048806|GO:0010035|GO:0009967|GO:0044249|GO:0010876|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0032370|GO:0000165|GO:0050679|GO:0030501|GO:0032268|GO:0042307|GO:0048705|GO:0045940|GO:0010468|GO:0005126|GO:0071773|GO:0034645|GO:0051216|GO:0007166|GO:0001654|GO:0033993|GO:0043412|GO:0072594|GO:0046661|GO:0061458|GO:0001655|GO:0010629|GO:0030539|GO:0002237|GO:0060586|GO:0010720|GO:0002064|GO:0046982|GO:0048878|GO:0051252|GO:0006066|GO:0032386|GO:0046886|GO:0051223|GO:0045667|GO:0015031|GO:0005125|GO:0046889|GO:0031214|GO:0010628|GO:0010038|GO:0001935|GO:0036211|GO:0030856|GO:0070201|GO:0071219|GO:0046907|GO:0072001|GO:0006954|GO:0055082|GO:0050714|GO:0001649|GO:0032330|GO:0006700|GO:0051046|GO:0033612|GO:0003309|GO:0035270|GO:0050769|GO:0032368|GO:0006869|GO:0009914|GO:0009306|GO:0051247|GO:0070848|GO:0031988|GO:0030858|GO:0006259|GO:0050678|GO:1904591|GO:0045669|GO:0034613|GO:0010565|GO:0008202|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0051054|GO:0006796|GO:0032526|GO:0035556|GO:0071241|GO:0044267|GO:0051174|GO:0010467|GO:0017038|GO:0008610|GO:0007399|GO:0019216|GO:0046903|GO:0071310|GO:0060349|GO:0060395|GO:0046890|GO:0031328|GO:0032332|GO:0051246|GO:0071260|GO:0010039|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0061035|GO:1903827|GO:1902531|GO:0016070|GO:0008083|GO:0010557|GO:0032496|GO:0030282|GO:0043067|GO:0048545|GO:0006606|GO:0051960|GO:0030500|GO:0006705|GO:0046885|GO:0032026|GO:0030182|GO:0003323|GO:0003158|GO:1904589|GO:0035932|GO:0060391|GO:0045893|GO:0090031|GO:0060393|GO:0033365|GO:0033157|GO:0031401|GO:0006260|GO:0010566|GO:0051169|GO:0030855|GO:0043408|GO:0060350|GO:0045892|GO:0002062|GO:0032774|GO:0060390|GO:0002066|GO:0019218|GO:2001141|GO:0050708|GO:0071363|GO:0016310|GO:0006605|GO:0032349|GO:1902679|GO:0016482|GO:0001936|GO:0006694|GO:0071281|GO:0006886|GO:0030509|GO:0007167|GO:0010862|GO:0006275|GO:0050810|GO:0042981|GO:0050801|GO:0001938|GO:0001958|GO:0005160|GO:0042306|GO:0045603|GO:0045740|GO:1900180|GO:0022008|GO:0006464|GO:0007184|GO:0045601|GO:0050767|GO:0071396|GO:0031960|GO:0046879|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0032342|GO:0071248|GO:0071222|GO:0046824|GO:0031663|GO:0045666|GO:0051384|GO:1903533|GO:0045944|GO:0045446|GO:0006366|GO:0006913|GO:1903507|GO:0070700|GO:0006357|GO:0006261|GO:0006468|GO:0048699|GO:1903506|GO:0002068|GO:2000860|GO:0042325|GO:0001932|GO:2000105|GO:0001934|GO:0007178|GO:0000122|GO:0045664|GO:0030003|GO:0042327|GO:0034504|GO:0046822|GO:0002067|GO:0051170|GO:0055065|GO:0060389|GO:0006875|GO:0035883|GO:0006879|GO:0055072 developmental process|growth|reproduction|immune system process|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|response to activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|hormone metabolic process|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|extracellular space|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|regulation of cell differentiation|cellular aromatic compound metabolic process|kidney development|positive regulation of hormone secretion|tissue development|cell development|transport|response to mechanical stimulus|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|regulation of lipopolysaccharide-mediated signaling pathway|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|defense response|positive regulation of cartilage development|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of hormone metabolic process|positive regulation of biomineral tissue development|positive regulation of cell differentiation|reproductive structure development|cytoplasm|cell-cell signaling|sensory organ development|regulation of protein localization|positive regulation of protein transport|organ morphogenesis|homeostatic process|endocrine pancreas development|regulation of signal transduction|protein dimerization activity|sex differentiation|epithelial cell proliferation|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|cellular homeostasis|multicellular organismal homeostasis|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|positive regulation of protein localization to nucleus|protein localization|cell communication|positive regulation of ossification|lipid metabolic process|signal transduction|C21-steroid hormone metabolic process|regulation of ossification|ossification|cellular ketone metabolic process|establishment of localization in cell|hormone biosynthetic process|response to hormone|cell death|positive regulation of intracellular protein transport|bone development|positive regulation of lipopolysaccharide-mediated signaling pathway|pancreas development|positive regulation of secretion|regulation of hormone levels|cellular developmental process|genitalia development|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of lipid transport|MAPK cascade|positive regulation of epithelial cell proliferation|positive regulation of bone mineralization|regulation of cellular protein metabolic process|positive regulation of protein import into nucleus|skeletal system morphogenesis|positive regulation of steroid metabolic process|regulation of gene expression|cytokine receptor binding|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|cartilage development|cell surface receptor signaling pathway|eye development|response to lipid|macromolecule modification|establishment of protein localization to organelle|male sex differentiation|reproductive system development|urogenital system development|negative regulation of gene expression|male genitalia development|response to molecule of bacterial origin|multicellular organismal iron ion homeostasis|positive regulation of cell development|epithelial cell development|protein heterodimerization activity|chemical homeostasis|regulation of RNA metabolic process|alcohol metabolic process|regulation of intracellular transport|positive regulation of hormone biosynthetic process|regulation of protein transport|regulation of osteoblast differentiation|protein transport|cytokine activity|positive regulation of lipid biosynthetic process|biomineral tissue development|positive regulation of gene expression|response to metal ion|endothelial cell proliferation|protein modification process|regulation of epithelial cell differentiation|regulation of establishment of protein localization|cellular response to molecule of bacterial origin|intracellular transport|renal system development|inflammatory response|cellular chemical homeostasis|positive regulation of protein secretion|osteoblast differentiation|regulation of chondrocyte differentiation|C21-steroid hormone biosynthetic process|regulation of secretion|receptor serine/threonine kinase binding|type B pancreatic cell differentiation|endocrine system development|positive regulation of neurogenesis|regulation of lipid transport|lipid transport|hormone transport|protein secretion|positive regulation of protein metabolic process|response to growth factor|membrane-bounded vesicle|positive regulation of epithelial cell differentiation|DNA metabolic process|regulation of epithelial cell proliferation|positive regulation of protein import|positive regulation of osteoblast differentiation|cellular protein localization|regulation of cellular ketone metabolic process|steroid metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|response to retinoic acid|intracellular signal transduction|cellular response to inorganic substance|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|protein import|lipid biosynthetic process|nervous system development|regulation of lipid metabolic process|secretion|cellular response to organic substance|bone morphogenesis|SMAD protein signal transduction|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|positive regulation of chondrocyte differentiation|regulation of protein metabolic process|cellular response to mechanical stimulus|response to iron ion|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|regulation of cartilage development|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|growth factor activity|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|bone mineralization|regulation of programmed cell death|response to steroid hormone|protein import into nucleus|regulation of nervous system development|regulation of bone mineralization|mineralocorticoid biosynthetic process|regulation of hormone biosynthetic process|response to magnesium ion|neuron differentiation|type B pancreatic cell development|endothelium development|regulation of protein import|aldosterone secretion|positive regulation of SMAD protein import into nucleus|positive regulation of transcription, DNA-templated|positive regulation of steroid hormone biosynthetic process|regulation of pathway-restricted SMAD protein phosphorylation|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|DNA replication|regulation of ketone biosynthetic process|nuclear transport|epithelial cell differentiation|regulation of MAPK cascade|endochondral bone morphogenesis|negative regulation of transcription, DNA-templated|chondrocyte differentiation|RNA biosynthetic process|regulation of SMAD protein import into nucleus|columnar/cuboidal epithelial cell development|regulation of steroid metabolic process|regulation of RNA biosynthetic process|regulation of protein secretion|cellular response to growth factor stimulus|phosphorylation|protein targeting|positive regulation of aldosterone biosynthetic process|negative regulation of RNA biosynthetic process|cytosolic transport|regulation of endothelial cell proliferation|steroid biosynthetic process|cellular response to iron ion|intracellular protein transport|BMP signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of DNA replication|regulation of steroid biosynthetic process|regulation of apoptotic process|ion homeostasis|positive regulation of endothelial cell proliferation|endochondral ossification|transforming growth factor beta receptor binding|regulation of protein import into nucleus|positive regulation of endothelial cell differentiation|positive regulation of DNA replication|regulation of protein localization to nucleus|neurogenesis|cellular protein modification process|SMAD protein import into nucleus|regulation of endothelial cell differentiation|regulation of neurogenesis|cellular response to lipid|response to corticosteroid|hormone secretion|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|aldosterone biosynthetic process|cellular response to metal ion|cellular response to lipopolysaccharide|positive regulation of nucleocytoplasmic transport|lipopolysaccharide-mediated signaling pathway|positive regulation of neuron differentiation|response to glucocorticoid|regulation of protein targeting|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|BMP receptor binding|regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|glandular epithelial cell development|positive regulation of aldosterone secretion|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of DNA-dependent DNA replication|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of neuron differentiation|cellular cation homeostasis|positive regulation of phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|glandular epithelial cell differentiation|nuclear import|metal ion homeostasis|pathway-restricted SMAD protein phosphorylation|cellular metal ion homeostasis|enteroendocrine cell differentiation|cellular iron ion homeostasis|iron ion homeostasis K16620 bone morphogenetic protein 6[-] hsa04390|hsa04350|hsa04913 Hippo signaling pathway - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human)|Ovarian steroidogenesis - Homo sapiens (human) 6:7726797-7881422 14 17 45 86 83 86 0.356236022382449 0.393134733813687 1.03234252421637 1.96063344228477 1.73278975573369 2.05081988129057 0.593904426804169 1.91474769310301 -1.68885160906076 2.11476488357039e-05 0.000198847845146805 DOWN ENSG00000204852 TCTN1 tectonic family member 1 [Source:HGNC Symbol;Acc:HGNC:26113] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0023051|GO:0009653|GO:0016043|GO:0005615|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0035239|GO:0009888|GO:0048468|GO:0035295|GO:0007275|GO:0048513|GO:0030900|GO:0021517|GO:0007420|GO:0005737|GO:0007389|GO:0060322|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0072372|GO:0036038|GO:0010646|GO:0007154|GO:0035148|GO:0007165|GO:0035869|GO:0030030|GO:0048869|GO:0021537|GO:0006996|GO:0000902|GO:0005829|GO:0031175|GO:0007166|GO:0002009|GO:0007417|GO:0021510|GO:0008589|GO:0000904|GO:0009790|GO:0072175|GO:0003002|GO:0021532|GO:0016331|GO:0001841|GO:0060429|GO:0032990|GO:0007399|GO:0060562|GO:0030154|GO:0048858|GO:0021522|GO:0005856|GO:0031513|GO:0048666|GO:0030182|GO:0060271|GO:0021953|GO:0009792|GO:0021904|GO:0007224|GO:0001838|GO:0021515|GO:0061564|GO:0021954|GO:0009953|GO:0022008|GO:0048667|GO:0048812|GO:0021523|GO:0021955|GO:0007409|GO:0048699|GO:0043009|GO:0021956|GO:0001701 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|regulation of signaling|anatomical structure morphogenesis|cellular component organization|extracellular space|intracellular|protein binding|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|tube morphogenesis|tissue development|cell development|tube development|multicellular organism development|animal organ development|forebrain development|ventral spinal cord development|brain development|cytoplasm|pattern specification process|head development|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|primary cilium|TCTN-B9D complex|regulation of cell communication|cell communication|tube formation|signal transduction|ciliary transition zone|cell projection organization|cellular developmental process|telencephalon development|organelle organization|cell morphogenesis|cytosol|neuron projection development|cell surface receptor signaling pathway|morphogenesis of an epithelium|central nervous system development|spinal cord development|regulation of smoothened signaling pathway|cell morphogenesis involved in differentiation|embryo development|epithelial tube formation|regionalization|neural tube patterning|morphogenesis of embryonic epithelium|neural tube formation|epithelium development|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|cell differentiation|cell projection morphogenesis|spinal cord motor neuron differentiation|cytoskeleton|nonmotile primary cilium|neuron development|neuron differentiation|cilium morphogenesis|central nervous system neuron differentiation|embryo development ending in birth or egg hatching|dorsal/ventral neural tube patterning|smoothened signaling pathway|embryonic epithelial tube formation|cell differentiation in spinal cord|axon development|central nervous system neuron development|dorsal/ventral pattern formation|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|somatic motor neuron differentiation|central nervous system neuron axonogenesis|axonogenesis|generation of neurons|chordate embryonic development|central nervous system interneuron axonogenesis|in utero embryonic development - - - - 12:110614027-110649430 195 222 284 494 558 440 0.710611212915703 0.73524192785294 0.933104916211966 1.612957359043 1.66839800870515 1.5027249929018 0.792986018993536 1.59469345354998 -1.00791178736004 2.11781859973931e-05 0.000199072281097662 DOWN ENSG00000202198 RN7SK RNA, 7SK small nuclear [Source:HGNC Symbol;Acc:HGNC:10037] - - - - - - 6:52995620-52995950 14 15 7 2 0 2 2.99195209130879 2.91341376387889 1.34867972749283 0.382965876778457 0 0.400518098959022 2.41801519422684 0.261161325245826 3.21081013759802 2.1243255556729e-05 0.000199621073777334 UP ENSG00000282304 RP11-1223D19.3 - - - - - - - 2:110245591-110285856 44 43 70 154 189 102 2.27349108226228 2.01927276410362 3.26101544416543 7.12953302439176 8.01259472913003 4.93936612821919 2.51792643017711 6.69383129391366 -1.41059606051736 2.1602387315752e-05 0.000202740544144754 DOWN ENSG00000022567 SLC45A4 solute carrier family 45 member 4 [Source:HGNC Symbol;Acc:HGNC:29196] GO:0005215|GO:0016020|GO:0022857|GO:0031224|GO:0006810|GO:0022891|GO:0016021|GO:0015075|GO:0051119|GO:0008643|GO:0015293|GO:0008324|GO:0005351|GO:0008506|GO:0015770|GO:0015295 transporter activity|membrane|transmembrane transporter activity|intrinsic component of membrane|transport|substrate-specific transmembrane transporter activity|integral component of membrane|ion transmembrane transporter activity|sugar transmembrane transporter activity|carbohydrate transport|symporter activity|cation transmembrane transporter activity|sugar:proton symporter activity|sucrose:proton symporter activity|sucrose transport|solute:proton symporter activity - - - - 8:141207166-141308305 288 418 531 788 840 963 1.61121431369473 2.12528892109829 2.67836479812397 3.94989281719967 3.85574748833773 5.04913094814049 2.13828934430566 4.28492375122596 -1.00281244661143 2.17448999371293e-05 0.000203949809212396 DOWN ENSG00000213047 DENND1B DENN/MADD domain containing 1B [Source:HGNC Symbol;Acc:HGNC:28404] GO:0005623|GO:0008152|GO:0043229|GO:0043227|GO:0009893|GO:0005622|GO:0005085|GO:0019222|GO:0006810|GO:0031982|GO:0043231|GO:0005737|GO:0005088|GO:0045184|GO:0043085|GO:0008104|GO:0050790|GO:0005829|GO:0031410|GO:0051345|GO:0015031|GO:0017112|GO:0016023|GO:0031988|GO:0043087|GO:0043547|GO:0030135|GO:0030136 cell|metabolic process|intracellular organelle|membrane-bounded organelle|positive regulation of metabolic process|intracellular|guanyl-nucleotide exchange factor activity|regulation of metabolic process|transport|vesicle|intracellular membrane-bounded organelle|cytoplasm|Ras guanyl-nucleotide exchange factor activity|establishment of protein localization|positive regulation of catalytic activity|protein localization|regulation of catalytic activity|cytosol|cytoplasmic vesicle|positive regulation of hydrolase activity|protein transport|Rab guanyl-nucleotide exchange factor activity|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|regulation of GTPase activity|positive regulation of GTPase activity|coated vesicle|clathrin-coated vesicle - - - - 1:197504748-197775696 168 254 316 485 576 559 0.511349770347802 0.702623697421844 0.867182893465214 1.3226615991315 1.43846837323802 1.5945949127225 0.693718787078287 1.45190829503067 -1.06552747232063 2.19253584281166e-05 0.000205513234070013 DOWN ENSG00000147536 GINS4 GINS complex subunit 4 (Sld5 homolog) [Source:HGNC Symbol;Acc:HGNC:28226] GO:0032502|GO:0040007|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0008283|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0032993|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0007049|GO:0006281|GO:0001824|GO:0006725|GO:1901360|GO:0007275|GO:0031261|GO:0034641|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0005737|GO:0001833|GO:0006139|GO:0001832|GO:0031298|GO:0044249|GO:0006996|GO:0051276|GO:0034645|GO:0000725|GO:0000811|GO:0009790|GO:0006302|GO:0016818|GO:0000278|GO:0005657|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0009059|GO:0005634|GO:0006974|GO:0006270|GO:0000724|GO:0009792|GO:0006260|GO:0043596|GO:0022616|GO:0006310|GO:0071103|GO:0016462|GO:0006271|GO:0006261|GO:0032392|GO:0017111|GO:0000727|GO:0043009|GO:0032508|GO:0001701|GO:0004386|GO:0003678|GO:0043138 developmental process|growth|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell proliferation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|protein-DNA complex|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|cell cycle|DNA repair|blastocyst development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|DNA replication preinitiation complex|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|inner cell mass cell proliferation|nucleobase-containing compound metabolic process|blastocyst growth|replication fork protection complex|cellular biosynthetic process|organelle organization|chromosome organization|cellular macromolecule biosynthetic process|recombinational repair|GINS complex|embryo development|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|mitotic cell cycle|replication fork|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|DNA replication initiation|double-strand break repair via homologous recombination|embryo development ending in birth or egg hatching|DNA replication|nuclear replication fork|DNA strand elongation|DNA recombination|DNA conformation change|pyrophosphatase activity|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication|DNA geometric change|nucleoside-triphosphatase activity|double-strand break repair via break-induced replication|chordate embryonic development|DNA duplex unwinding|in utero embryonic development|helicase activity|DNA helicase activity|3'-5' DNA helicase activity - - - - 8:41529206-41545046 198 279 242 613 714 390 1.24011936189354 1.58811649590209 1.36655640987093 3.43998124886159 3.66913787141457 2.28924070017961 1.39826408922219 3.13278660681859 -1.16380963499213 2.19611869869722e-05 0.000205784455840888 DOWN ENSG00000280332 CTD-2013N17.6 - - - - - - - 19:16356329-16358327 9 4 14 35 33 38 0.318476836922428 0.128638923619949 0.446669698826408 1.10967166779447 0.958115463430998 1.26020029582536 0.297928486456262 1.10932914235028 -1.89664950364956 2.21078942176286e-05 0.000207029195098207 DOWN ENSG00000175906 ARL4D ADP ribosylation factor like GTPase 4D [Source:HGNC Symbol;Acc:HGNC:656] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0006810|GO:0043168|GO:0032940|GO:0001882|GO:0016817|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0000166|GO:0005730|GO:0035639|GO:0001883|GO:0015031|GO:0016818|GO:0032549|GO:0031981|GO:0009306|GO:0035556|GO:0046903|GO:0017076|GO:0005634|GO:0032561|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0017111|GO:0003924 signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|transport|anion binding|secretion by cell|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|nucleotide binding|nucleolus|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|nuclear lumen|protein secretion|intracellular signal transduction|secretion|purine nucleotide binding|nucleus|guanyl ribonucleotide binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|GTPase activity - - - - 17:43398959-43401137 116 117 137 48 59 71 5.09025488069512 4.66603273443486 5.42019820366729 1.88719149423324 2.12424155940041 2.91988340931836 5.05882860626576 2.310438820984 1.13063647296585 2.21793335268217e-05 0.000207437914508062 UP ENSG00000234210 AC006372.4 - - - - - - - 7:157466231-157499716 16 8 2 0 0 0 0.27952661598408 0.127018625989764 0.0315031128657513 0 0 0 0.146016118279865 0 Inf 2.23982380169939e-05 0.000209419667322059 UP ENSG00000069493 CLEC2D C-type lectin domain family 2 member D [Source:HGNC Symbol;Acc:HGNC:14351] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0006955|GO:0009986|GO:0038023|GO:0030246|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0002682|GO:0005886|GO:0012505|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0031226|GO:0050776|GO:0007154|GO:0007165|GO:0005783|GO:0016021|GO:0007166 signal transducer activity|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|immune response|cell surface|signaling receptor activity|carbohydrate binding|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|regulation of immune system process|plasma membrane|endomembrane system|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|intrinsic component of plasma membrane|regulation of immune response|cell communication|signal transduction|endoplasmic reticulum|integral component of membrane|cell surface receptor signaling pathway - - - - 12:9664969-9699555 19 17 21 42 74 73 0.112362747804497 0.0913731761560113 0.111972721156602 0.222550931466852 0.359068552635751 0.404606141905111 0.105236215039037 0.328741875335905 -1.64332397338095 2.24673785045519e-05 0.000210000349992139 DOWN ENSG00000040487 PQLC2 PQ loop repeat containing 2 [Source:HGNC Symbol;Acc:HGNC:26001] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0006810|GO:0043231|GO:0005774|GO:0005737|GO:0042592|GO:0022891|GO:0055085|GO:0016021|GO:0031301|GO:0048878|GO:0005773|GO:1903825|GO:0006811|GO:0015075|GO:0034220|GO:0098655|GO:0006820|GO:0015711|GO:0098656|GO:0000323|GO:1990822|GO:0008509|GO:0006812|GO:0046942|GO:0046943|GO:0050801|GO:0006865|GO:0005765|GO:0008324|GO:1903401|GO:0015171|GO:0005764|GO:0003333|GO:0015807|GO:0055081|GO:0015181|GO:0008514|GO:0015809|GO:0015819|GO:0015802|GO:0015189|GO:1903826|GO:0015174|GO:1902475|GO:0015179|GO:0080144 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|transport|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|homeostatic process|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|integral component of organelle membrane|chemical homeostasis|vacuole|organic acid transmembrane transport|ion transport|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|lytic vacuole|basic amino acid transmembrane transport|anion transmembrane transporter activity|cation transport|carboxylic acid transport|carboxylic acid transmembrane transporter activity|ion homeostasis|amino acid transport|lysosomal membrane|cation transmembrane transporter activity|L-lysine transmembrane transport|amino acid transmembrane transporter activity|lysosome|amino acid transmembrane transport|L-amino acid transport|anion homeostasis|arginine transmembrane transporter activity|organic anion transmembrane transporter activity|arginine transport|lysine transport|basic amino acid transport|L-lysine transmembrane transporter activity|arginine transmembrane transport|basic amino acid transmembrane transporter activity|L-alpha-amino acid transmembrane transport|L-amino acid transmembrane transporter activity|amino acid homeostasis - - - - 1:19312326-19329300 388 377 280 180 201 160 5.68355381692216 5.01891557433569 3.69794726042734 2.36242881755187 2.41574905510409 2.19653325299079 4.80013888389506 2.32490370854892 1.04590518358689 2.2674944289218e-05 0.000211807818150912 UP ENSG00000188295 ZNF669 zinc finger protein 669 [Source:HGNC Symbol;Acc:HGNC:25736] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 1:247099962-247104372 199 262 215 121 115 118 2.83288559180909 3.38967058658004 2.75949166096757 1.54332755755138 1.34320086632197 1.5743017084074 2.99401594645223 1.48694337742692 1.00973219453335 2.2920652891537e-05 0.000213872268025181 UP ENSG00000150175 FRMPD2B FERM and PDZ domain containing 2B, pseudogene [Source:HGNC Symbol;Acc:HGNC:16843] - - - - - - 10:46870858-46894562 3 1 3 12 17 20 0.157560370689639 0.0477488691439787 0.142019882563676 0.564640112310332 0.732492961760548 0.984302851562855 0.115776374132431 0.760478641877912 -2.71556685000341 2.29439518090164e-05 0.000213985859827047 DOWN ENSG00000152104 PTPN14 protein tyrosine phosphatase, non-receptor type 14 [Source:HGNC Symbol;Acc:HGNC:9647] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0003824|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0000989|GO:0009653|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0001946|GO:0060341|GO:0042127|GO:0003712|GO:0006725|GO:0006810|GO:1901360|GO:0007275|GO:0001945|GO:0005102|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0032880|GO:0045184|GO:0006139|GO:0008104|GO:0051649|GO:0008285|GO:0036303|GO:0044249|GO:0019538|GO:0031323|GO:0010468|GO:0034645|GO:0001944|GO:0043412|GO:0072358|GO:0051252|GO:0032386|GO:0051223|GO:0015031|GO:0030971|GO:0036211|GO:0070201|GO:0046907|GO:0031981|GO:0005654|GO:0034613|GO:0019900|GO:0006796|GO:0044267|GO:0010467|GO:0009059|GO:1903827|GO:0016070|GO:0072359|GO:0005856|GO:0005634|GO:0042578|GO:0016311|GO:0033157|GO:0051169|GO:0032774|GO:2001141|GO:0006611|GO:0016482|GO:0006886|GO:0016791|GO:0019901|GO:0006464|GO:0006351|GO:0006355|GO:0006470|GO:0006913|GO:1903506|GO:0046825|GO:0004721|GO:1990782|GO:0046822|GO:0035335|GO:0051168|GO:0004725 developmental process|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|catalytic activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|lymphangiogenesis|regulation of cellular localization|regulation of cell proliferation|transcription cofactor activity|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|multicellular organism development|lymph vessel development|receptor binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of protein localization|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|establishment of localization in cell|negative regulation of cell proliferation|lymph vessel morphogenesis|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|vasculature development|macromolecule modification|cardiovascular system development|regulation of RNA metabolic process|regulation of intracellular transport|regulation of protein transport|protein transport|receptor tyrosine kinase binding|protein modification process|regulation of establishment of protein localization|intracellular transport|nuclear lumen|nucleoplasm|cellular protein localization|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|regulation of cellular protein localization|RNA metabolic process|circulatory system development|cytoskeleton|nucleus|phosphoric ester hydrolase activity|dephosphorylation|regulation of intracellular protein transport|nuclear transport|RNA biosynthetic process|regulation of RNA biosynthetic process|protein export from nucleus|cytosolic transport|intracellular protein transport|phosphatase activity|protein kinase binding|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|protein dephosphorylation|nucleocytoplasmic transport|regulation of nucleic acid-templated transcription|regulation of protein export from nucleus|phosphoprotein phosphatase activity|protein tyrosine kinase binding|regulation of nucleocytoplasmic transport|peptidyl-tyrosine dephosphorylation|nuclear export|protein tyrosine phosphatase activity - - - - 1:214348696-214552449 507 709 1384 1865 2028 2364 1.82632815954151 2.32111461010939 4.49491034880198 6.01931469794235 5.99385993186837 7.98081052331251 2.88078437281763 6.66466171770774 -1.21006997084337 2.31248016921554e-05 0.00021553788002423 DOWN ENSG00000075275 CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 [Source:HGNC Symbol;Acc:HGNC:1850] GO:0040011|GO:0032502|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0006950|GO:0043167|GO:0051641|GO:0038023|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0007626|GO:0048856|GO:0048646|GO:0035239|GO:0009888|GO:0007164|GO:0035295|GO:0048839|GO:0007275|GO:0030324|GO:0048513|GO:0051128|GO:0098609|GO:0005887|GO:0043231|GO:0043169|GO:0004888|GO:0001942|GO:0007389|GO:0032970|GO:0001763|GO:0009611|GO:0007423|GO:0006928|GO:0009887|GO:0021915|GO:0048729|GO:0046983|GO:0048598|GO:0048568|GO:0030323|GO:0031226|GO:0008104|GO:0007154|GO:0035148|GO:0016477|GO:0007165|GO:0048869|GO:0016021|GO:0030029|GO:0006996|GO:0060425|GO:0007186|GO:0098742|GO:0008105|GO:0046872|GO:0007166|GO:0032956|GO:0002009|GO:0007010|GO:0007417|GO:0043583|GO:0022405|GO:0060541|GO:0048754|GO:0061138|GO:0009790|GO:0001736|GO:0072175|GO:0042060|GO:0001764|GO:2000027|GO:0042472|GO:0003002|GO:0031981|GO:0016331|GO:0005654|GO:0043588|GO:0030036|GO:0001841|GO:0034613|GO:0060429|GO:0035556|GO:0033043|GO:0090177|GO:0048562|GO:0007399|GO:0060562|GO:0030154|GO:0060606|GO:0004930|GO:0005634|GO:0051960|GO:0045995|GO:0042633|GO:0016055|GO:0009792|GO:0001843|GO:0042249|GO:0001838|GO:0008544|GO:0005509|GO:0090175|GO:0042471|GO:0051493|GO:0007156|GO:0045176|GO:0009952|GO:0090178|GO:0060441|GO:0022008|GO:0060601|GO:0007264|GO:0090251|GO:0098773|GO:0001738|GO:0035567|GO:0007265|GO:0048699|GO:0090179|GO:0048105|GO:0060448|GO:0043009|GO:0060490|GO:0060071|GO:0060489|GO:0060488|GO:0007266 locomotion|developmental process|signal transducer activity|behavior|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|response to stress|ion binding|cellular localization|signaling receptor activity|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|locomotory behavior|anatomical structure development|anatomical structure formation involved in morphogenesis|tube morphogenesis|tissue development|establishment of tissue polarity|tube development|inner ear development|multicellular organism development|lung development|animal organ development|regulation of cellular component organization|cell-cell adhesion|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|transmembrane signaling receptor activity|hair follicle development|pattern specification process|regulation of actin filament-based process|morphogenesis of a branching structure|response to wounding|sensory organ development|movement of cell or subcellular component|organ morphogenesis|neural tube development|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|embryonic organ development|respiratory tube development|intrinsic component of plasma membrane|protein localization|cell communication|tube formation|cell migration|signal transduction|cellular developmental process|integral component of membrane|actin filament-based process|organelle organization|lung morphogenesis|G-protein coupled receptor signaling pathway|cell-cell adhesion via plasma-membrane adhesion molecules|asymmetric protein localization|metal ion binding|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|morphogenesis of an epithelium|cytoskeleton organization|central nervous system development|ear development|hair cycle process|respiratory system development|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|embryo development|establishment of planar polarity|epithelial tube formation|wound healing|neuron migration|regulation of organ morphogenesis|inner ear morphogenesis|regionalization|nuclear lumen|morphogenesis of embryonic epithelium|nucleoplasm|skin development|actin cytoskeleton organization|neural tube formation|cellular protein localization|epithelium development|intracellular signal transduction|regulation of organelle organization|establishment of planar polarity involved in neural tube closure|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|cell differentiation|tube closure|G-protein coupled receptor activity|nucleus|regulation of nervous system development|regulation of embryonic development|hair cycle|Wnt signaling pathway|embryo development ending in birth or egg hatching|neural tube closure|establishment of planar polarity of embryonic epithelium|embryonic epithelial tube formation|epidermis development|calcium ion binding|regulation of establishment of planar polarity|ear morphogenesis|regulation of cytoskeleton organization|homophilic cell adhesion via plasma membrane adhesion molecules|apical protein localization|anterior/posterior pattern specification|regulation of establishment of planar polarity involved in neural tube closure|epithelial tube branching involved in lung morphogenesis|neurogenesis|lateral sprouting from an epithelium|small GTPase mediated signal transduction|protein localization involved in establishment of planar polarity|skin epidermis development|morphogenesis of a polarized epithelium|non-canonical Wnt signaling pathway|Ras protein signal transduction|generation of neurons|planar cell polarity pathway involved in neural tube closure|establishment of body hair planar orientation|dichotomous subdivision of terminal units involved in lung branching|chordate embryonic development|lateral sprouting involved in lung morphogenesis|Wnt signaling pathway, planar cell polarity pathway|planar dichotomous subdivision of terminal units involved in lung branching morphogenesis|orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis|Rho protein signal transduction - - - - 22:46360834-46537170 765 806 1904 2341 2799 3807 3.09876083381606 2.96716637032845 6.9535746337466 8.49622669593807 9.30245785606368 14.4523561057037 4.3398339459637 10.7503468859018 -1.30867146526458 2.32548025937909e-05 0.000216546748794458 DOWN ENSG00000212232 SNORD17 small nucleolar RNA, C/D box 17 [Source:HGNC Symbol;Acc:HGNC:32713] - - - - - - 20:17962710-17962946 11 21 16 62 61 40 3.28313216415301 5.69647159627987 4.30569127403973 16.580103903796 14.9381676268913 11.1889552694546 4.42843167815754 14.235742266714 -1.68464995243983 2.35213784870291e-05 0.000218892529099677 DOWN ENSG00000197977 ELOVL2 ELOVL fatty acid elongase 2 [Source:HGNC Symbol;Acc:HGNC:14416] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0006082|GO:0044281|GO:0043231|GO:0016746|GO:0005737|GO:0051186|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0006790|GO:0046486|GO:0006637|GO:0006631|GO:0006638|GO:0016747|GO:0008610|GO:0033559|GO:0004312|GO:0001676|GO:0009108|GO:0000038|GO:0006633|GO:0019752|GO:0006639|GO:0006636|GO:0042761|GO:0036109|GO:0009922|GO:0043651|GO:0046949|GO:0032787|GO:0030497|GO:0035336|GO:0006641|GO:0019432|GO:0035338|GO:0034626 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|cofactor metabolic process|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|sulfur compound metabolic process|glycerolipid metabolic process|acyl-CoA metabolic process|fatty acid metabolic process|neutral lipid metabolic process|transferase activity, transferring acyl groups other than amino-acyl groups|lipid biosynthetic process|unsaturated fatty acid metabolic process|fatty acid synthase activity|long-chain fatty acid metabolic process|coenzyme biosynthetic process|very long-chain fatty acid metabolic process|fatty acid biosynthetic process|carboxylic acid metabolic process|acylglycerol metabolic process|unsaturated fatty acid biosynthetic process|very long-chain fatty acid biosynthetic process|alpha-linolenic acid metabolic process|fatty acid elongase activity|linoleic acid metabolic process|fatty-acyl-CoA biosynthetic process|monocarboxylic acid metabolic process|fatty acid elongation|long-chain fatty-acyl-CoA metabolic process|triglyceride metabolic process|triglyceride biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|fatty acid elongation, polyunsaturated fatty acid K10205 elongation of very long chain fatty acids protein 2[2.3.1.199] hsa01212|hsa00062|hsa01040 Fatty acid metabolism - Homo sapiens (human)|Fatty acid elongation - Homo sapiens (human)|Biosynthesis of unsaturated fatty acids - Homo sapiens (human) 6:10980759-11044314 4 14 22 47 45 68 0.0707866529378685 0.225174438105322 0.351025868294711 0.745259918739846 0.653425302893702 1.12784458836328 0.215662319779301 0.842176603332276 -1.96534866343539 2.37056510476176e-05 0.000220469939680865 DOWN ENSG00000170417 TMEM182 transmembrane protein 182 [Source:HGNC Symbol;Acc:HGNC:26391] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 2:102736908-102843893 61 67 112 197 193 203 0.340727989036577 0.340119998733064 0.564035184662879 0.985913707767541 0.884505594742464 1.06267361921087 0.414961057477507 0.977697640573625 -1.2364124198711 2.39161718101425e-05 0.000222081926351475 DOWN ENSG00000183023 SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 [Source:HGNC Symbol;Acc:HGNC:11068] GO:0040011|GO:0032502|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0022857|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0043167|GO:0009628|GO:0051641|GO:0048870|GO:0005911|GO:0040017|GO:0043227|GO:0071944|GO:0009605|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0030017|GO:0007507|GO:0060341|GO:0030018|GO:0051272|GO:0051282|GO:0050817|GO:0043198|GO:0042391|GO:0009888|GO:0048468|GO:0044325|GO:0006810|GO:0009612|GO:0009991|GO:0007275|GO:0048513|GO:0044291|GO:0005874|GO:0030900|GO:2000147|GO:0033554|GO:0007420|GO:0070169|GO:0061061|GO:0005887|GO:0030315|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0003012|GO:0009611|GO:0060322|GO:0035902|GO:0006928|GO:0042592|GO:0043005|GO:0042383|GO:0043197|GO:0019725|GO:0036477|GO:0022891|GO:0031674|GO:0006979|GO:0042493|GO:0010646|GO:0031226|GO:0005516|GO:0007154|GO:0045778|GO:0055085|GO:0051270|GO:0016477|GO:0007165|GO:0030278|GO:0001503|GO:0051649|GO:0008092|GO:2000021|GO:0002026|GO:0001666|GO:0051238|GO:0002027|GO:0048869|GO:0016021|GO:2000145|GO:0010035|GO:0021537|GO:0010033|GO:0050878|GO:0003013|GO:0007584|GO:0030501|GO:0030506|GO:0005829|GO:0009743|GO:0035150|GO:0006936|GO:0046872|GO:0014074|GO:0051899|GO:0044309|GO:0072358|GO:0061337|GO:0007417|GO:0042542|GO:0042692|GO:0048878|GO:0007596|GO:0046683|GO:0035051|GO:0010644|GO:0032386|GO:0048738|GO:0014704|GO:0098735|GO:0055006|GO:0031214|GO:0090257|GO:0001508|GO:0071417|GO:0051208|GO:0030334|GO:0001667|GO:0071456|GO:0060537|GO:0042060|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0015075|GO:0051279|GO:0043279|GO:0043292|GO:0007599|GO:0034599|GO:0030425|GO:0035994|GO:0034765|GO:0033198|GO:0005739|GO:0051591|GO:0055001|GO:0010649|GO:0071453|GO:0043269|GO:0014070|GO:0000302|GO:0035556|GO:0090075|GO:0007399|GO:0071310|GO:0010522|GO:0030154|GO:0030335|GO:0072359|GO:0031667|GO:0008015|GO:0005856|GO:0030282|GO:0086065|GO:0030500|GO:0034220|GO:0006941|GO:0008016|GO:0055002|GO:0071415|GO:0071312|GO:0098655|GO:0086001|GO:0030016|GO:0006939|GO:0006937|GO:0086010|GO:0055013|GO:0015297|GO:0060047|GO:0010763|GO:0006812|GO:0010880|GO:0034284|GO:0014808|GO:0060402|GO:0005509|GO:0071407|GO:0016482|GO:0015630|GO:0055119|GO:0010762|GO:0051146|GO:0050801|GO:0071320|GO:0034614|GO:0014706|GO:0044557|GO:0055007|GO:0019932|GO:0010761|GO:0031000|GO:0006873|GO:0090279|GO:0086064|GO:0008324|GO:0050880|GO:0070296|GO:0036294|GO:1903169|GO:0010881|GO:0014829|GO:0006942|GO:0060048|GO:0042310|GO:0022890|GO:0015491|GO:0055117|GO:0002028|GO:0030001|GO:0019722|GO:0051924|GO:0071313|GO:0086012|GO:0030003|GO:0015672|GO:0035725|GO:0070588|GO:0010882|GO:0006814|GO:0055065|GO:0097553|GO:0006875|GO:0009749|GO:0015077|GO:0015368|GO:0046873|GO:0006874|GO:0071436|GO:0006816|GO:0006883|GO:0055074|GO:0055078|GO:0005432|GO:0015085|GO:0015081|GO:0097369|GO:0051480|GO:1901660|GO:0070509|GO:0060401|GO:0051481|GO:0007204 locomotion|developmental process|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|transmembrane transporter activity|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|ion binding|response to abiotic stimulus|cellular localization|cell motility|cell-cell junction|positive regulation of locomotion|membrane-bounded organelle|cell periphery|response to external stimulus|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|sarcomere|heart development|regulation of cellular localization|Z disc|positive regulation of cellular component movement|regulation of sequestering of calcium ion|coagulation|dendritic shaft|regulation of membrane potential|tissue development|cell development|ion channel binding|transport|response to mechanical stimulus|response to extracellular stimulus|multicellular organism development|animal organ development|cell-cell contact zone|microtubule|forebrain development|positive regulation of cell motility|cellular response to stress|brain development|positive regulation of biomineral tissue development|muscle structure development|integral component of plasma membrane|T-tubule|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|muscle system process|response to wounding|head development|response to immobilization stress|movement of cell or subcellular component|homeostatic process|neuron projection|sarcolemma|dendritic spine|cellular homeostasis|somatodendritic compartment|substrate-specific transmembrane transporter activity|I band|response to oxidative stress|response to drug|regulation of cell communication|intrinsic component of plasma membrane|calmodulin binding|cell communication|positive regulation of ossification|transmembrane transport|regulation of cellular component movement|cell migration|signal transduction|regulation of ossification|ossification|establishment of localization in cell|cytoskeletal protein binding|regulation of ion homeostasis|regulation of the force of heart contraction|response to hypoxia|sequestering of metal ion|regulation of heart rate|cellular developmental process|integral component of membrane|regulation of cell motility|response to inorganic substance|telencephalon development|response to organic substance|regulation of body fluid levels|circulatory system process|response to nutrient|positive regulation of bone mineralization|ankyrin binding|cytosol|response to carbohydrate|regulation of tube size|muscle contraction|metal ion binding|response to purine-containing compound|membrane depolarization|neuron spine|cardiovascular system development|cardiac conduction|central nervous system development|response to hydrogen peroxide|muscle cell differentiation|chemical homeostasis|blood coagulation|response to organophosphorus|cardiocyte differentiation|cell communication by electrical coupling|regulation of intracellular transport|cardiac muscle tissue development|intercalated disc|positive regulation of the force of heart contraction|cardiac cell development|biomineral tissue development|regulation of muscle system process|action potential|cellular response to organonitrogen compound|sequestering of calcium ion|regulation of cell migration|ameboidal-type cell migration|cellular response to hypoxia|muscle tissue development|wound healing|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol|response to alkaloid|contractile fiber|hemostasis|cellular response to oxidative stress|dendrite|response to muscle stretch|regulation of ion transmembrane transport|response to ATP|mitochondrion|response to cAMP|muscle cell development|regulation of cell communication by electrical coupling|cellular response to oxygen levels|regulation of ion transport|response to organic cyclic compound|response to reactive oxygen species|intracellular signal transduction|relaxation of muscle|nervous system development|cellular response to organic substance|regulation of calcium ion transport into cytosol|cell differentiation|positive regulation of cell migration|circulatory system development|response to nutrient levels|blood circulation|cytoskeleton|bone mineralization|cell communication involved in cardiac conduction|regulation of bone mineralization|ion transmembrane transport|striated muscle contraction|regulation of heart contraction|striated muscle cell development|cellular response to purine-containing compound|cellular response to alkaloid|cation transmembrane transport|cardiac muscle cell action potential|myofibril|smooth muscle contraction|regulation of muscle contraction|membrane depolarization during action potential|cardiac muscle cell development|antiporter activity|heart contraction|positive regulation of fibroblast migration|cation transport|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to monosaccharide|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|calcium ion transport into cytosol|calcium ion binding|cellular response to organic cyclic compound|cytosolic transport|microtubule cytoskeleton|relaxation of cardiac muscle|regulation of fibroblast migration|striated muscle cell differentiation|ion homeostasis|cellular response to cAMP|cellular response to reactive oxygen species|striated muscle tissue development|relaxation of smooth muscle|cardiac muscle cell differentiation|second-messenger-mediated signaling|fibroblast migration|response to caffeine|cellular ion homeostasis|regulation of calcium ion import|cell communication by electrical coupling involved in cardiac conduction|cation transmembrane transporter activity|regulation of blood vessel size|sarcoplasmic reticulum calcium ion transport|cellular response to decreased oxygen levels|regulation of calcium ion transmembrane transport|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|vascular smooth muscle contraction|regulation of striated muscle contraction|cardiac muscle contraction|vasoconstriction|inorganic cation transmembrane transporter activity|cation:cation antiporter activity|regulation of cardiac muscle contraction|regulation of sodium ion transport|metal ion transport|calcium-mediated signaling|regulation of calcium ion transport|cellular response to caffeine|membrane depolarization during cardiac muscle cell action potential|cellular cation homeostasis|monovalent inorganic cation transport|sodium ion transmembrane transport|calcium ion transmembrane transport|regulation of cardiac muscle contraction by calcium ion signaling|sodium ion transport|metal ion homeostasis|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|response to glucose|monovalent inorganic cation transmembrane transporter activity|calcium:cation antiporter activity|metal ion transmembrane transporter activity|cellular calcium ion homeostasis|sodium ion export|calcium ion transport|cellular sodium ion homeostasis|calcium ion homeostasis|sodium ion homeostasis|calcium:sodium antiporter activity|calcium ion transmembrane transporter activity|sodium ion transmembrane transporter activity|sodium ion import|regulation of cytosolic calcium ion concentration|calcium ion export|calcium ion import|cytosolic calcium ion transport|negative regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K05849 solute carrier family 8 (sodium/calcium exchanger)[-] hsa04740|hsa04020|hsa04022|hsa04261|hsa04974|hsa05414|hsa05410|hsa04260|hsa05412|hsa04978|hsa04961 Olfactory transduction - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)|Mineral absorption - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) 2:40097270-40611053 6 12 21 52 62 34 0.0134512813441409 0.0244508137602242 0.0424489150186718 0.104455519607344 0.114048709511859 0.0714398088759159 0.0267836700410123 0.0966480126650396 -1.85138640721248 2.39096773831772e-05 0.000222081926351475 DOWN ENSG00000105219 CNTD2 cyclin N-terminal domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25805] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - 19:40222208-40226690 33 13 30 7 7 3 0.488860098159747 0.175029393023199 0.400685824407889 0.0929076249511666 0.0850823516321817 0.0416454944781475 0.354858438530278 0.0732118236871653 2.27709504677608 2.39451077049883e-05 0.000222281481786294 UP ENSG00000137478 FCHSD2 FCH and double SH3 domains 2 [Source:HGNC Symbol;Acc:HGNC:29114] GO:0005488|GO:0005515 binding|protein binding - - - - 11:72836745-73142261 184 229 369 506 609 640 1.36503114116439 1.54397719987045 2.46811400916904 3.36335830198779 3.70689246818051 4.44973637281281 1.79237411673463 3.83999571432704 -1.09923290268654 2.41863453624902e-05 0.000224172354688539 DOWN ENSG00000261008 LINC01572 long intergenic non-protein coding RNA 1572 [Source:HGNC Symbol;Acc:HGNC:51385] - - - - - - 16:72283301-72665009 1 1 3 11 9 35 0.0134588614345024 0.0122323557886914 0.0363828036921399 0.132589828750316 0.0993413014194445 0.441286260026957 0.0206913403051112 0.224405796732239 -3.43901093781556 2.43618228639811e-05 0.000225518716211253 DOWN ENSG00000272391 POM121C POM121 transmembrane nucleoporin C [Source:HGNC Symbol;Acc:HGNC:34005] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane K14316 nuclear pore complex protein Nup121[-] hsa03013 RNA transport - Homo sapiens (human) 7:75416787-75486271 4115 4145 2462 2008 2068 1606 24.8363619364973 22.7364506645887 13.3973969595845 10.8587419892762 10.2408626622178 9.08432638730304 20.3234031868902 10.0613103462657 1.01432379554893 2.43913783832492e-05 0.000225722321839281 UP ENSG00000163795 ZNF513 zinc finger protein 513 [Source:HGNC Symbol;Acc:HGNC:26498] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0060041|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0007423|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0001654|GO:0051252|GO:0007600|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0050953|GO:0043010|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0007601 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|retina development in camera-type eye|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|sensory organ development|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|eye development|regulation of RNA metabolic process|sensory perception|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|sensory perception of light stimulus|camera-type eye development|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|visual perception - - - - 2:27377231-27380790 399 435 259 199 184 124 6.20580116640751 6.14885814183225 3.63194406395108 2.77316906340849 2.34807438191625 1.80749564162117 5.32886779073028 2.30957969564864 1.20619871077399 2.45444653733963e-05 0.000227068630076657 UP ENSG00000235257 ITGA9-AS1 ITGA9 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49668] - - - - - - 3:37745432-37861780 17 16 26 49 69 62 0.114284708286757 0.0977567794397559 0.157590059262575 0.295149743434407 0.380594854861464 0.3906300922516 0.123210515663029 0.35545823018249 -1.528554647873 2.46199556443633e-05 0.000227696454710912 DOWN ENSG00000173692 PSMD1 proteasome 26S subunit, non-ATPase 1 [Source:HGNC Symbol;Acc:HGNC:9554] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0019882|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0016787|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0002757|GO:0051726|GO:0007049|GO:0006935|GO:0045087|GO:0048468|GO:0019884|GO:0022402|GO:0010941|GO:0006082|GO:0007275|GO:0034641|GO:0044281|GO:0006952|GO:0031982|GO:0031325|GO:0033554|GO:0045786|GO:0043231|GO:0008233|GO:0010243|GO:0005737|GO:0006520|GO:0002218|GO:0006928|GO:0009966|GO:0005838|GO:0000502|GO:0045787|GO:0060548|GO:0010646|GO:0043085|GO:0022624|GO:0050776|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0009968|GO:0070062|GO:0042180|GO:0008540|GO:0009725|GO:0008219|GO:0050790|GO:0048002|GO:0030030|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0043487|GO:0010033|GO:0031324|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0030111|GO:0000902|GO:0005829|GO:0045732|GO:0031175|GO:0010468|GO:0000075|GO:0030178|GO:0090068|GO:0007166|GO:1903047|GO:0043412|GO:0002758|GO:0034097|GO:0030163|GO:0043069|GO:0009308|GO:0044770|GO:0044265|GO:1901652|GO:0007050|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0006521|GO:0002429|GO:0031981|GO:0051351|GO:0007346|GO:0043434|GO:0044344|GO:0010564|GO:0051247|GO:0045930|GO:0070848|GO:0006508|GO:0005654|GO:0002764|GO:0002474|GO:0010565|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0042176|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030177|GO:0030154|GO:0048858|GO:0072395|GO:1902531|GO:0032870|GO:0005634|GO:0043067|GO:0045089|GO:0006974|GO:0031597|GO:0045088|GO:0043488|GO:0010948|GO:0048666|GO:0030182|GO:0007411|GO:0016055|GO:0044257|GO:0019221|GO:0042590|GO:0031401|GO:0008543|GO:0090090|GO:0071156|GO:0010498|GO:0051436|GO:1901653|GO:0043408|GO:0060828|GO:0007093|GO:0072331|GO:0042770|GO:0038061|GO:1903364|GO:0044772|GO:0030162|GO:0051444|GO:0045862|GO:0051439|GO:0071363|GO:0016310|GO:0010608|GO:0002768|GO:0044774|GO:0038179|GO:0000077|GO:0061564|GO:1901990|GO:0051603|GO:0007167|GO:0004175|GO:0006576|GO:0071375|GO:0043410|GO:0034515|GO:0042981|GO:0071345|GO:0043066|GO:0019752|GO:0032868|GO:1901987|GO:0051438|GO:0034612|GO:0051443|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050851|GO:0090263|GO:0048812|GO:0043549|GO:0006915|GO:0044773|GO:1901991|GO:0071158|GO:0033674|GO:0048011|GO:0000186|GO:2000045|GO:0007265|GO:0002223|GO:0045859|GO:1903052|GO:0045860|GO:0007409|GO:0044819|GO:0019941|GO:0006468|GO:0048699|GO:0071356|GO:0060070|GO:0044783|GO:0043405|GO:0042325|GO:0002479|GO:0001932|GO:1902806|GO:0032869|GO:0038093|GO:2000134|GO:0000082|GO:0033209|GO:0001934|GO:0050852|GO:0031571|GO:0042327|GO:1902807|GO:0006977|GO:0030330|GO:0051437|GO:0043161|GO:0072422|GO:0006595|GO:0007169|GO:0032446|GO:0048010|GO:0072431|GO:0006511|GO:0031398|GO:2000058|GO:0038095|GO:0031396|GO:0031397|GO:2000060|GO:0071900|GO:0032147|GO:0008286|GO:0031145|GO:0038127|GO:0007173|GO:0042787|GO:0016567|GO:0000209 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|antigen processing and presentation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein complex|anatomical structure development|regulation of metabolic process|viral process|immune response-activating signal transduction|regulation of cell cycle|cell cycle|chemotaxis|innate immune response|cell development|antigen processing and presentation of exogenous antigen|cell cycle process|regulation of cell death|organic acid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|vesicle|positive regulation of cellular metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|peptidase activity|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|activation of innate immune response|movement of cell or subcellular component|regulation of signal transduction|proteasome regulatory particle|proteasome complex|positive regulation of cell cycle|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|proteasome accessory complex|regulation of immune response|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|negative regulation of signal transduction|extracellular exosome|cellular ketone metabolic process|proteasome regulatory particle, base subcomplex|response to hormone|cell death|regulation of catalytic activity|antigen processing and presentation of peptide antigen|cell projection organization|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of RNA stability|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|positive regulation of protein catabolic process|neuron projection development|regulation of gene expression|cell cycle checkpoint|negative regulation of Wnt signaling pathway|positive regulation of cell cycle process|cell surface receptor signaling pathway|mitotic cell cycle process|macromolecule modification|innate immune response-activating signal transduction|response to cytokine|protein catabolic process|negative regulation of programmed cell death|amine metabolic process|cell cycle phase transition|cellular macromolecule catabolic process|response to peptide|cell cycle arrest|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of cellular amino acid metabolic process|immune response-activating cell surface receptor signaling pathway|nuclear lumen|positive regulation of ligase activity|regulation of mitotic cell cycle|response to peptide hormone|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|response to growth factor|proteolysis|nucleoplasm|immune response-regulating signaling pathway|antigen processing and presentation of peptide antigen via MHC class I|regulation of cellular ketone metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|cell differentiation|cell projection morphogenesis|signal transduction involved in cell cycle checkpoint|regulation of intracellular signal transduction|cellular response to hormone stimulus|nucleus|regulation of programmed cell death|positive regulation of innate immune response|cellular response to DNA damage stimulus|cytosolic proteasome complex|regulation of innate immune response|regulation of mRNA stability|negative regulation of cell cycle process|neuron development|neuron differentiation|axon guidance|Wnt signaling pathway|cellular protein catabolic process|cytokine-mediated signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of cell cycle arrest|proteasomal protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|cellular response to peptide|regulation of MAPK cascade|regulation of canonical Wnt signaling pathway|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|NIK/NF-kappaB signaling|positive regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of proteolysis|negative regulation of ubiquitin-protein transferase activity|positive regulation of proteolysis|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|cellular response to growth factor stimulus|phosphorylation|posttranscriptional regulation of gene expression|immune response-regulating cell surface receptor signaling pathway|mitotic DNA integrity checkpoint|neurotrophin signaling pathway|DNA damage checkpoint|axon development|regulation of mitotic cell cycle phase transition|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|endopeptidase activity|cellular biogenic amine metabolic process|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|proteasome storage granule|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|carboxylic acid metabolic process|response to insulin|regulation of cell cycle phase transition|regulation of ubiquitin-protein transferase activity|response to tumor necrosis factor|positive regulation of ubiquitin-protein transferase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|antigen receptor-mediated signaling pathway|positive regulation of canonical Wnt signaling pathway|neuron projection morphogenesis|regulation of kinase activity|apoptotic process|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|regulation of G1/S transition of mitotic cell cycle|Ras protein signal transduction|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|positive regulation of proteolysis involved in cellular protein catabolic process|positive regulation of protein kinase activity|axonogenesis|mitotic G1/S transition checkpoint|modification-dependent protein catabolic process|protein phosphorylation|generation of neurons|cellular response to tumor necrosis factor|canonical Wnt signaling pathway|G1 DNA damage checkpoint|regulation of MAP kinase activity|regulation of phosphorylation|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|cellular response to insulin stimulus|Fc receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|tumor necrosis factor-mediated signaling pathway|positive regulation of protein phosphorylation|T cell receptor signaling pathway|mitotic G1 DNA damage checkpoint|positive regulation of phosphorylation|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|proteasome-mediated ubiquitin-dependent protein catabolic process|signal transduction involved in DNA damage checkpoint|polyamine metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|signal transduction involved in mitotic G1 DNA damage checkpoint|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Fc-epsilon receptor signaling pathway|regulation of protein ubiquitination|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination K03032 26S proteasome regulatory subunit N2[-] hsa05169|hsa03050 Epstein-Barr virus infection - Homo sapiens (human)|Proteasome - Homo sapiens (human) 2:231056864-231172827 1501 1835 1671 4044 4084 2578 13.2886125689473 14.764374397795 13.3379668122438 32.0780365436062 29.6655656769742 21.3899985827133 13.7969845929954 27.7112002677646 -1.00611620777201 2.46427659992531e-05 0.000227766296019103 DOWN ENSG00000144395 CCDC150 coiled-coil domain containing 150 [Source:HGNC Symbol;Acc:HGNC:26834] GO:0005488|GO:0005515 binding|protein binding - - - - 2:196639554-196763490 26 47 39 115 110 87 0.110095115091361 0.180876002536614 0.148896178012269 0.436310903085533 0.382174398735642 0.345259803374169 0.146622431880081 0.387915035065115 -1.40363485447703 2.46775284458863e-05 0.000227949829132295 DOWN ENSG00000180979 LRRC57 leucine rich repeat containing 57 [Source:HGNC Symbol;Acc:HGNC:26719] GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0005515|GO:0031982|GO:0070062 membrane|extracellular region|binding|extracellular vesicle|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 15:42537820-42548802 512 579 416 316 265 211 2.81583274398872 2.89398058843408 2.06274313070249 1.55711740968957 1.19578055326349 1.08754899653697 2.5908521543751 1.28014898649668 1.01711496727476 2.4704876124631e-05 0.000228128478758037 UP ENSG00000127946 HIP1 huntingtin interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:4913] GO:0032502|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0005200|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0008289|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0060627|GO:0034641|GO:0043168|GO:0005543|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0030276|GO:0022607|GO:0010942|GO:0045807|GO:0043231|GO:0005737|GO:0012506|GO:0006139|GO:0043085|GO:0007154|GO:0061024|GO:0007165|GO:0008092|GO:0008219|GO:0050790|GO:0048869|GO:0044249|GO:0019538|GO:0031323|GO:0005794|GO:0006996|GO:0016192|GO:0032268|GO:0010468|GO:0034645|GO:0006900|GO:0016050|GO:0031410|GO:0051345|GO:0035091|GO:0051252|GO:0003779|GO:0048260|GO:0051604|GO:0016023|GO:0030665|GO:0030100|GO:0051247|GO:0006508|GO:0031988|GO:0006461|GO:0032270|GO:0012501|GO:0030659|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0030154|GO:0043068|GO:0016070|GO:0005856|GO:0005634|GO:0043067|GO:0097190|GO:0034622|GO:0043065|GO:0016485|GO:0048259|GO:0032774|GO:0030162|GO:2001141|GO:0043623|GO:0045862|GO:0052547|GO:0030135|GO:0042981|GO:0006897|GO:0010952|GO:0006351|GO:0006915|GO:0006355|GO:0030136|GO:0048268|GO:0010950|GO:0043281|GO:1903506|GO:0006898|GO:0031638|GO:0043280|GO:0006919|GO:0052548|GO:0072583|GO:2001056|GO:2000116|GO:0097202 developmental process|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|structural constituent of cytoskeleton|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|lipid binding|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|regulation of vesicle-mediated transport|cellular nitrogen compound metabolic process|anion binding|phospholipid binding|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|clathrin binding|cellular component assembly|positive regulation of cell death|positive regulation of endocytosis|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|membrane organization|signal transduction|cytoskeletal protein binding|cell death|regulation of catalytic activity|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|vesicle-mediated transport|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|cytoplasmic vesicle|positive regulation of hydrolase activity|phosphatidylinositol binding|regulation of RNA metabolic process|actin binding|positive regulation of receptor-mediated endocytosis|protein maturation|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|regulation of endocytosis|positive regulation of protein metabolic process|proteolysis|membrane-bounded vesicle|protein complex assembly|positive regulation of cellular protein metabolic process|programmed cell death|cytoplasmic vesicle membrane|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|RNA metabolic process|cytoskeleton|nucleus|regulation of programmed cell death|apoptotic signaling pathway|cellular macromolecular complex assembly|positive regulation of apoptotic process|protein processing|regulation of receptor-mediated endocytosis|RNA biosynthetic process|regulation of proteolysis|regulation of RNA biosynthetic process|cellular protein complex assembly|positive regulation of proteolysis|regulation of peptidase activity|coated vesicle|regulation of apoptotic process|endocytosis|positive regulation of peptidase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|clathrin-coated vesicle|clathrin coat assembly|positive regulation of endopeptidase activity|regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of nucleic acid-templated transcription|receptor-mediated endocytosis|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of endopeptidase activity|clathrin-mediated endocytosis|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity K04559 huntingtin interacting protein 1[-] hsa05016 Huntington,s disease - Homo sapiens (human) 7:75533300-75738962 354 517 1060 1575 1345 2271 1.80644019482979 2.39767462123336 4.87685757172985 7.20108762441439 5.63131804346939 10.8609021960688 3.026990795931 7.89776928798419 -1.38356093555378 2.47357459267505e-05 0.000228342906276193 DOWN ENSG00000241370 RPP21 ribonuclease P/MRP 21kDa subunit [Source:HGNC Symbol;Acc:HGNC:21300] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0043234|GO:0006725|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0043169|GO:0030529|GO:0042493|GO:0006139|GO:0005730|GO:0046872|GO:0030677|GO:0031981|GO:0004518|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0090501|GO:0006396|GO:0034660|GO:0005655|GO:0004519|GO:0004540|GO:0090305|GO:0006399|GO:0090502|GO:0004521|GO:0008033|GO:0004526|GO:0016891 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|intracellular ribonucleoprotein complex|response to drug|nucleobase-containing compound metabolic process|nucleolus|metal ion binding|ribonuclease P complex|nuclear lumen|nuclease activity|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA phosphodiester bond hydrolysis|RNA processing|ncRNA metabolic process|nucleolar ribonuclease P complex|endonuclease activity|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|tRNA metabolic process|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|tRNA processing|ribonuclease P activity|endoribonuclease activity, producing 5'-phosphomonoesters - - - - 6:30345131-30346884 698 672 456 337 363 256 13.0550888606638 11.4228259773798 7.68959742956379 5.64743785538466 5.57055170844458 4.48737872004439 10.7225040892025 5.23512276129121 1.03434659294903 2.48537305546079e-05 0.000229290257100514 UP ENSG00000125804 FAM182A family with sequence similarity 182 member A [Source:HGNC Symbol;Acc:HGNC:16222] - - - - - - 20:26054655-26086917 2 2 4 19 9 32 0.0210234991672359 0.0191075351698824 0.0379123507188073 0.17895736965728 0.0776246935448713 0.315266149366709 0.0260144616853085 0.190616070856287 -2.87328399892088 2.50221731478807e-05 0.000230701654464741 DOWN ENSG00000156030 ELMSAN1 ELM2 and Myb/SANT-like domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19853] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 14:73715122-73790285 984 1107 2923 636 667 834 2.72736463020612 2.78853237237975 7.30451027509688 1.57943951159805 1.51684627758592 2.16642068439937 4.27346909256092 1.75423549119445 1.28456525795084 2.50213193106478e-05 0.000230701654464741 UP ENSG00000129673 AANAT aralkylamine N-acetyltransferase [Source:HGNC Symbol;Acc:HGNC:19] GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0006807|GO:0007623|GO:0071704|GO:0009628|GO:0044237|GO:0042445|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:0009314|GO:1901360|GO:0034641|GO:0044281|GO:0046483|GO:0016746|GO:0010243|GO:0005737|GO:0071889|GO:0042446|GO:0009725|GO:0010817|GO:0010035|GO:0044249|GO:0019538|GO:0010033|GO:0005829|GO:0014074|GO:0033993|GO:0043412|GO:0034097|GO:0009308|GO:0046683|GO:1901652|GO:0071417|GO:0010038|GO:0036211|GO:0043434|GO:0048471|GO:0046688|GO:0051591|GO:0016747|GO:0070542|GO:0014070|GO:0010043|GO:0043603|GO:0044267|GO:0071310|GO:0009416|GO:0048545|GO:0097305|GO:0030187|GO:0051412|GO:0051592|GO:0009648|GO:0071407|GO:0009309|GO:0016407|GO:0034695|GO:0006576|GO:0016410|GO:0032868|GO:0071320|GO:0006464|GO:0031960|GO:0031365|GO:0051384|GO:0046219|GO:0051385|GO:0008080|GO:0004060|GO:0004059|GO:0006473|GO:0006474 cell|rhythmic process|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|nitrogen compound metabolic process|circadian rhythm|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|hormone metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|transferase activity, transferring acyl groups|response to organonitrogen compound|cytoplasm|14-3-3 protein binding|hormone biosynthetic process|response to hormone|regulation of hormone levels|response to inorganic substance|cellular biosynthetic process|protein metabolic process|response to organic substance|cytosol|response to purine-containing compound|response to lipid|macromolecule modification|response to cytokine|amine metabolic process|response to organophosphorus|response to peptide|cellular response to organonitrogen compound|response to metal ion|protein modification process|response to peptide hormone|perinuclear region of cytoplasm|response to copper ion|response to cAMP|transferase activity, transferring acyl groups other than amino-acyl groups|response to fatty acid|response to organic cyclic compound|response to zinc ion|cellular amide metabolic process|cellular protein metabolic process|cellular response to organic substance|response to light stimulus|response to steroid hormone|response to alcohol|melatonin biosynthetic process|response to corticosterone|response to calcium ion|photoperiodism|cellular response to organic cyclic compound|amine biosynthetic process|acetyltransferase activity|response to prostaglandin E|cellular biogenic amine metabolic process|N-acyltransferase activity|response to insulin|cellular response to cAMP|cellular protein modification process|response to corticosteroid|N-terminal protein amino acid modification|response to glucocorticoid|indolalkylamine biosynthetic process|response to mineralocorticoid|N-acetyltransferase activity|arylamine N-acetyltransferase activity|aralkylamine N-acetyltransferase activity|protein acetylation|N-terminal protein amino acid acetylation K00669 arylalkylamine N-acetyltransferase[2.3.1.87] hsa01100|hsa00380 Metabolic pathways - Homo sapiens (human)|Tryptophan metabolism - Homo sapiens (human) 17:76453351-76470117 12 12 16 4 2 2 0.287459876846217 0.261241999644034 0.345563437841997 0.0858528311640159 0.0393052264882396 0.044893833645593 0.298088438110749 0.0566839637659495 2.39472786802152 2.57017351134419e-05 0.000236600809038597 UP ENSG00000136997 MYC v-myc avian myelocytomatosis viral oncogene homolog [Source:HGNC Symbol;Acc:HGNC:7553] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0002683|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:1903706|GO:0045595|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0009314|GO:0006810|GO:0022402|GO:0035295|GO:1901360|GO:2001022|GO:0010941|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0051302|GO:0072028|GO:0034641|GO:0015980|GO:0032204|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0010942|GO:0045786|GO:0043231|GO:0000723|GO:0072111|GO:0048144|GO:0005737|GO:0000981|GO:0001763|GO:0071559|GO:0009887|GO:0032403|GO:0042592|GO:0009966|GO:0048729|GO:0046983|GO:0072006|GO:0050673|GO:0051782|GO:0009890|GO:0019725|GO:0060548|GO:0042493|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0009968|GO:0008134|GO:0008219|GO:0008285|GO:0050790|GO:0006091|GO:0051301|GO:0048869|GO:0044249|GO:0090184|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0072089|GO:0055114|GO:0000165|GO:0050679|GO:0051276|GO:0000982|GO:0005730|GO:1901724|GO:0032268|GO:0005829|GO:0003677|GO:0010468|GO:0034645|GO:0007166|GO:0002009|GO:0043412|GO:0072164|GO:0030097|GO:0051345|GO:0001655|GO:0010629|GO:0043069|GO:0048878|GO:0051252|GO:0006325|GO:0070491|GO:0010463|GO:0048754|GO:0061138|GO:0007050|GO:0072203|GO:0001656|GO:0010628|GO:0036211|GO:0032269|GO:0071560|GO:2000027|GO:0072001|GO:0055082|GO:0048145|GO:0060485|GO:0031981|GO:0031098|GO:2001020|GO:0071478|GO:0051247|GO:0048146|GO:0070848|GO:0006508|GO:0005654|GO:0006259|GO:0050678|GO:0061326|GO:0006112|GO:0032270|GO:0060993|GO:0012501|GO:0060429|GO:0051054|GO:0006796|GO:0010212|GO:0035556|GO:0072073|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0060562|GO:0071310|GO:1902532|GO:0048147|GO:0031328|GO:0051246|GO:0035690|GO:0009059|GO:0030154|GO:0001228|GO:0001823|GO:0043068|GO:1902531|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0009416|GO:0005819|GO:0043067|GO:0045638|GO:0006974|GO:2000648|GO:0045637|GO:0072091|GO:0002521|GO:0002761|GO:0016055|GO:0000975|GO:0045893|GO:0010332|GO:0032200|GO:0043065|GO:0009411|GO:0001657|GO:0043408|GO:0045892|GO:0032774|GO:0043565|GO:0030162|GO:2001141|GO:0072078|GO:0001077|GO:0045862|GO:0071363|GO:0072163|GO:0016310|GO:0001658|GO:0033044|GO:1902679|GO:0052547|GO:0007179|GO:0003690|GO:0002762|GO:2000278|GO:0061333|GO:0002053|GO:0007167|GO:0015630|GO:0090096|GO:0072075|GO:0071482|GO:0072080|GO:0032872|GO:0042981|GO:0050801|GO:0043066|GO:0043409|GO:0016568|GO:0090094|GO:2000573|GO:0030099|GO:0007219|GO:0006464|GO:0010952|GO:0015671|GO:0051403|GO:0071897|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0010464|GO:0045944|GO:0006366|GO:0072133|GO:0002573|GO:0044346|GO:1903507|GO:0010950|GO:0045656|GO:0006352|GO:0006357|GO:0043281|GO:0006468|GO:1903506|GO:0044212|GO:0060070|GO:0042325|GO:0045655|GO:0001932|GO:0060675|GO:0042326|GO:0043280|GO:0007178|GO:0006338|GO:0001933|GO:0000122|GO:0034644|GO:0030003|GO:0032873|GO:0052548|GO:0006367|GO:2001056|GO:0030224|GO:0000976|GO:0055065|GO:0001012|GO:0006875|GO:0070888|GO:2000116|GO:0001159|GO:0000977|GO:0000987|GO:0006879|GO:0055072|GO:0000978 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of hemopoiesis|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|response to radiation|transport|cell cycle process|tube development|organic cyclic compound metabolic process|positive regulation of response to DNA damage stimulus|regulation of cell death|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|regulation of cell division|nephron morphogenesis|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|regulation of telomere maintenance|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of cell death|negative regulation of cell cycle|intracellular membrane-bounded organelle|telomere maintenance|cell proliferation involved in kidney development|fibroblast proliferation|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|morphogenesis of a branching structure|response to transforming growth factor beta|organ morphogenesis|protein complex binding|homeostatic process|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|nephron development|epithelial cell proliferation|negative regulation of cell division|negative regulation of biosynthetic process|cellular homeostasis|negative regulation of cell death|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|negative regulation of signal transduction|transcription factor binding|cell death|negative regulation of cell proliferation|regulation of catalytic activity|generation of precursor metabolites and energy|cell division|cellular developmental process|cellular biosynthetic process|positive regulation of kidney development|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|stem cell proliferation|oxidation-reduction process|MAPK cascade|positive regulation of epithelial cell proliferation|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nucleolus|positive regulation of cell proliferation involved in kidney development|regulation of cellular protein metabolic process|cytosol|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|morphogenesis of an epithelium|macromolecule modification|mesonephric tubule development|hemopoiesis|positive regulation of hydrolase activity|urogenital system development|negative regulation of gene expression|negative regulation of programmed cell death|chemical homeostasis|regulation of RNA metabolic process|chromatin organization|repressing transcription factor binding|mesenchymal cell proliferation|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|cell cycle arrest|cell proliferation involved in metanephros development|metanephros development|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|cellular response to transforming growth factor beta stimulus|regulation of organ morphogenesis|renal system development|cellular chemical homeostasis|regulation of fibroblast proliferation|mesenchyme development|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of response to DNA damage stimulus|cellular response to radiation|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|response to growth factor|proteolysis|nucleoplasm|DNA metabolic process|regulation of epithelial cell proliferation|renal tubule development|energy reserve metabolic process|positive regulation of cellular protein metabolic process|kidney morphogenesis|programmed cell death|epithelium development|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|response to ionizing radiation|intracellular signal transduction|kidney epithelium development|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|epithelial tube morphogenesis|cellular response to organic substance|negative regulation of intracellular signal transduction|negative regulation of fibroblast proliferation|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cellular response to drug|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|mesonephros development|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|spindle|regulation of programmed cell death|negative regulation of myeloid cell differentiation|cellular response to DNA damage stimulus|positive regulation of stem cell proliferation|regulation of myeloid cell differentiation|regulation of stem cell proliferation|leukocyte differentiation|regulation of myeloid leukocyte differentiation|Wnt signaling pathway|regulatory region DNA binding|positive regulation of transcription, DNA-templated|response to gamma radiation|telomere organization|positive regulation of apoptotic process|response to UV|ureteric bud development|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of proteolysis|regulation of RNA biosynthetic process|nephron tubule morphogenesis|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of proteolysis|cellular response to growth factor stimulus|mesonephric epithelium development|phosphorylation|branching involved in ureteric bud morphogenesis|regulation of chromosome organization|negative regulation of RNA biosynthetic process|regulation of peptidase activity|transforming growth factor beta receptor signaling pathway|double-stranded DNA binding|negative regulation of myeloid leukocyte differentiation|regulation of DNA biosynthetic process|renal tubule morphogenesis|positive regulation of mesenchymal cell proliferation|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|positive regulation of metanephric cap mesenchymal cell proliferation|metanephric mesenchyme development|cellular response to light stimulus|nephron tubule development|regulation of stress-activated MAPK cascade|regulation of apoptotic process|ion homeostasis|negative regulation of apoptotic process|negative regulation of MAPK cascade|chromatin modification|metanephric cap mesenchymal cell proliferation involved in metanephros development|positive regulation of DNA biosynthetic process|myeloid cell differentiation|Notch signaling pathway|cellular protein modification process|positive regulation of peptidase activity|oxygen transport|stress-activated MAPK cascade|DNA biosynthetic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|metanephric mesenchyme morphogenesis|myeloid leukocyte differentiation|fibroblast apoptotic process|negative regulation of nucleic acid-templated transcription|positive regulation of endopeptidase activity|negative regulation of monocyte differentiation|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|canonical Wnt signaling pathway|regulation of phosphorylation|regulation of monocyte differentiation|regulation of protein phosphorylation|ureteric bud morphogenesis|negative regulation of phosphorylation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|transmembrane receptor protein serine/threonine kinase signaling pathway|chromatin remodeling|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|cellular response to UV|cellular cation homeostasis|negative regulation of stress-activated MAPK cascade|regulation of endopeptidase activity|transcription initiation from RNA polymerase II promoter|positive regulation of cysteine-type endopeptidase activity|monocyte differentiation|transcription regulatory region sequence-specific DNA binding|metal ion homeostasis|RNA polymerase II regulatory region DNA binding|cellular metal ion homeostasis|E-box binding|regulation of cysteine-type endopeptidase activity|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|cellular iron ion homeostasis|iron ion homeostasis|RNA polymerase II core promoter proximal region sequence-specific DNA binding K04377 Myc proto-oncogene protein[-] hsa05200|hsa04151|hsa05166|hsa05206|hsa04010|hsa05205|hsa05169|hsa05202|hsa04630|hsa04390|hsa05161|hsa04310|hsa04550|hsa04110|hsa04919|hsa04012|hsa05222|hsa04350|hsa05220|hsa05230|hsa05210|hsa05221|hsa05213|hsa05219|hsa05216 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human)|Chronic myeloid leukemia - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Bladder cancer - Homo sapiens (human)|Thyroid cancer - Homo sapiens (human) 8:127735434-127741434 1439 1228 3423 967 1055 621 11.3567259556238 8.80786886664385 24.3564243834497 6.83779991397051 6.83144704760986 4.59317143839588 14.8403397352391 6.08747279999208 1.28560879342041 2.56942330230655e-05 0.000236600809038597 UP ENSG00000165695 AK8 adenylate kinase 8 [Source:HGNC Symbol;Acc:HGNC:26526] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0005929|GO:0006725|GO:0036126|GO:1901360|GO:0005930|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0007420|GO:0031514|GO:0005737|GO:0060322|GO:0006139|GO:0055086|GO:0000166|GO:0044249|GO:0005829|GO:0035639|GO:0007417|GO:0015949|GO:0001883|GO:0032549|GO:0016301|GO:0006796|GO:0021591|GO:0007399|GO:0017076|GO:0016776|GO:0009142|GO:0004017|GO:0009117|GO:0005524|GO:0004550|GO:0030554|GO:0016310|GO:0019205|GO:0009132|GO:0046939|GO:0019201|GO:0006165|GO:0004127 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|anatomical structure development|cilium|cellular aromatic compound metabolic process|sperm flagellum|organic cyclic compound metabolic process|axoneme|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|brain development|motile cilium|cytoplasm|head development|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|nucleotide binding|cellular biosynthetic process|cytosol|purine ribonucleoside triphosphate binding|central nervous system development|nucleobase-containing small molecule interconversion|purine nucleoside binding|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|ventricular system development|nervous system development|purine nucleotide binding|phosphotransferase activity, phosphate group as acceptor|nucleoside triphosphate biosynthetic process|adenylate kinase activity|nucleotide metabolic process|ATP binding|nucleoside diphosphate kinase activity|adenyl nucleotide binding|phosphorylation|nucleobase-containing compound kinase activity|nucleoside diphosphate metabolic process|nucleotide phosphorylation|nucleotide kinase activity|nucleoside diphosphate phosphorylation|cytidylate kinase activity K00939 adenylate kinase[2.7.4.3] hsa01100|hsa00230 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human) 9:132725578-132878777 13 5 10 29 39 48 0.280784564519266 0.0981578427643412 0.194742143501415 0.561225241677003 0.691138263468055 0.971645459124543 0.191228183595007 0.7413363214232 -1.95483303099118 2.57490553006263e-05 0.000236891308765762 DOWN ENSG00000128165 ADM2 adrenomedullin 2 [Source:HGNC Symbol;Acc:HGNC:28898] GO:0032502|GO:0007610|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0007631|GO:0044877|GO:0050794|GO:0071704|GO:0044237|GO:0009653|GO:0009893|GO:0050793|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0001568|GO:0007275|GO:0005102|GO:0032403|GO:0001525|GO:0007154|GO:0007165|GO:0007586|GO:0008217|GO:0019538|GO:0003013|GO:0007186|GO:0010468|GO:0001944|GO:0043412|GO:0072358|GO:0005179|GO:0010628|GO:0036211|GO:0045766|GO:0045765|GO:0045776|GO:0006796|GO:1901342|GO:0044267|GO:0010467|GO:0072359|GO:0008015|GO:0007187|GO:0016310|GO:0006464|GO:0007188|GO:0006468|GO:0007189 developmental process|behavior|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|feeding behavior|macromolecular complex binding|regulation of cellular process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|positive regulation of metabolic process|regulation of developmental process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|blood vessel development|multicellular organism development|receptor binding|protein complex binding|angiogenesis|cell communication|signal transduction|digestion|regulation of blood pressure|protein metabolic process|circulatory system process|G-protein coupled receptor signaling pathway|regulation of gene expression|vasculature development|macromolecule modification|cardiovascular system development|hormone activity|positive regulation of gene expression|protein modification process|positive regulation of angiogenesis|regulation of angiogenesis|negative regulation of blood pressure|phosphate-containing compound metabolic process|regulation of vasculature development|cellular protein metabolic process|gene expression|circulatory system development|blood circulation|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|phosphorylation|cellular protein modification process|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|protein phosphorylation|adenylate cyclase-activating G-protein coupled receptor signaling pathway - - - - 22:50481556-50486440 47 61 93 151 163 215 0.691050324451466 0.815122812612993 1.23283973494284 1.98922388141047 1.96637655411019 2.96262693306369 0.9130042906691 2.30607578952812 -1.33674638286663 2.57804587480976e-05 0.000237107152022707 DOWN ENSG00000248871 TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough [Source:HGNC Symbol;Acc:HGNC:33537] GO:0002376|GO:0016020|GO:0005576|GO:0050896|GO:0005488|GO:0006955|GO:0005615|GO:0005515|GO:0005102|GO:0005126|GO:0005125|GO:0032813|GO:0005164 immune system process|membrane|extracellular region|response to stimulus|binding|immune response|extracellular space|protein binding|receptor binding|cytokine receptor binding|cytokine activity|tumor necrosis factor receptor superfamily binding|tumor necrosis factor receptor binding - - - - 17:7549099-7561601 29 34 24 12 0 1 1.1296105269384 1.20361688914557 0.842844988748561 0.418816206653093 0 0.0365009611110782 1.05869080161084 0.151772389254724 2.80230003952568 2.58285225657503e-05 0.000237476043325503 UP ENSG00000206053 HN1L hematological and neurological expressed 1-like [Source:HGNC Symbol;Acc:HGNC:14137] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0043231|GO:0005737|GO:0005634 cell|membrane|intracellular organelle|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|intracellular membrane-bounded organelle|cytoplasm|nucleus - - - - 16:1678256-1702280 257 701 944 1531 1875 1697 1.54036213688694 3.81845697187643 5.1012494384648 8.22172371234906 9.2206058016203 9.53236851856193 3.48668951574272 8.99156601084376 -1.36671450366891 2.63268991157215e-05 0.000241834844984846 DOWN ENSG00000170458 CD14 CD14 molecule [Source:HGNC Symbol;Acc:HGNC:1628] GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0004872|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0071704|GO:0006955|GO:0009628|GO:0009986|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0008289|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0031224|GO:0005615|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0031225|GO:0060341|GO:0070891|GO:0002757|GO:0045087|GO:0009897|GO:0051602|GO:0006810|GO:0051130|GO:0010941|GO:0060627|GO:0032940|GO:0006952|GO:0046658|GO:0031982|GO:0031325|GO:0051128|GO:0046696|GO:0010942|GO:0001817|GO:0045807|GO:0043231|GO:0004888|GO:0005737|GO:0002218|GO:0001816|GO:0032880|GO:0008329|GO:0009408|GO:0043235|GO:0051222|GO:0009966|GO:0045184|GO:0001819|GO:0010646|GO:0031226|GO:0043085|GO:0009617|GO:0050776|GO:0008104|GO:0007154|GO:0007165|GO:0050778|GO:0070062|GO:0008219|GO:0001530|GO:0010008|GO:0051047|GO:0050790|GO:0016021|GO:0010035|GO:0009967|GO:0009266|GO:0019538|GO:0010033|GO:0098857|GO:0031323|GO:0005794|GO:0005768|GO:0016192|GO:2001235|GO:0032268|GO:0006909|GO:0032479|GO:0007166|GO:0033993|GO:0002758|GO:0001847|GO:0034097|GO:0051345|GO:0002237|GO:0031362|GO:0016019|GO:0051223|GO:0051604|GO:0015031|GO:0032481|GO:0010038|GO:0070201|GO:0071219|GO:0006954|GO:0050714|GO:0050715|GO:0051046|GO:0009306|GO:0032606|GO:0030100|GO:0051247|GO:0006508|GO:0002764|GO:0050663|GO:0032270|GO:0012501|GO:0035556|GO:0044267|GO:0032609|GO:0010467|GO:0046903|GO:0071310|GO:0051246|GO:0031233|GO:0045121|GO:0043068|GO:0050707|GO:0032729|GO:0032496|GO:0043067|GO:0045089|GO:0097305|GO:0097190|GO:0045088|GO:0032649|GO:0032026|GO:0032680|GO:0043065|GO:0016485|GO:0097296|GO:0030162|GO:0045862|GO:0050708|GO:0052547|GO:0032640|GO:0002221|GO:0045471|GO:0007249|GO:2001269|GO:0042981|GO:0034612|GO:0032760|GO:0006897|GO:0010952|GO:0071396|GO:0097191|GO:0071223|GO:0006915|GO:0071222|GO:0031663|GO:0010950|GO:0002224|GO:0043281|GO:0006898|GO:0031638|GO:0043280|GO:0006919|GO:0071221|GO:0052548|GO:0071726|GO:0071727|GO:0034134|GO:0038124|GO:2001056|GO:0002756|GO:0034138|GO:0002755|GO:2000116|GO:0034142|GO:0097202|GO:0038123|GO:0035666 macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|receptor activity|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|organic substance metabolic process|immune response|response to abiotic stimulus|cell surface|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|lipid binding|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|extracellular space|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|anchored component of membrane|regulation of cellular localization|lipoteichoic acid binding|immune response-activating signal transduction|innate immune response|external side of plasma membrane|response to electrical stimulus|transport|positive regulation of cellular component organization|regulation of cell death|regulation of vesicle-mediated transport|secretion by cell|defense response|anchored component of plasma membrane|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|lipopolysaccharide receptor complex|positive regulation of cell death|regulation of cytokine production|positive regulation of endocytosis|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|activation of innate immune response|cytokine production|regulation of protein localization|signaling pattern recognition receptor activity|response to heat|receptor complex|positive regulation of protein transport|regulation of signal transduction|establishment of protein localization|positive regulation of cytokine production|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|response to bacterium|regulation of immune response|protein localization|cell communication|signal transduction|positive regulation of immune response|extracellular exosome|cell death|lipopolysaccharide binding|endosome membrane|positive regulation of secretion|regulation of catalytic activity|integral component of membrane|response to inorganic substance|positive regulation of signal transduction|response to temperature stimulus|protein metabolic process|response to organic substance|membrane microdomain|regulation of cellular metabolic process|Golgi apparatus|endosome|vesicle-mediated transport|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|phagocytosis|regulation of type I interferon production|cell surface receptor signaling pathway|response to lipid|innate immune response-activating signal transduction|opsonin receptor activity|response to cytokine|positive regulation of hydrolase activity|response to molecule of bacterial origin|anchored component of external side of plasma membrane|peptidoglycan receptor activity|regulation of protein transport|protein maturation|protein transport|positive regulation of type I interferon production|response to metal ion|regulation of establishment of protein localization|cellular response to molecule of bacterial origin|inflammatory response|positive regulation of protein secretion|positive regulation of cytokine secretion|regulation of secretion|protein secretion|type I interferon production|regulation of endocytosis|positive regulation of protein metabolic process|proteolysis|immune response-regulating signaling pathway|cytokine secretion|positive regulation of cellular protein metabolic process|programmed cell death|intracellular signal transduction|cellular protein metabolic process|interferon-gamma production|gene expression|secretion|cellular response to organic substance|regulation of protein metabolic process|intrinsic component of external side of plasma membrane|membrane raft|positive regulation of programmed cell death|regulation of cytokine secretion|positive regulation of interferon-gamma production|response to lipopolysaccharide|regulation of programmed cell death|positive regulation of innate immune response|response to alcohol|apoptotic signaling pathway|regulation of innate immune response|regulation of interferon-gamma production|response to magnesium ion|regulation of tumor necrosis factor production|positive regulation of apoptotic process|protein processing|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|regulation of proteolysis|positive regulation of proteolysis|regulation of protein secretion|regulation of peptidase activity|tumor necrosis factor production|pattern recognition receptor signaling pathway|response to ethanol|I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|regulation of apoptotic process|response to tumor necrosis factor|positive regulation of tumor necrosis factor production|endocytosis|positive regulation of peptidase activity|cellular response to lipid|extrinsic apoptotic signaling pathway|cellular response to lipoteichoic acid|apoptotic process|cellular response to lipopolysaccharide|lipopolysaccharide-mediated signaling pathway|positive regulation of endopeptidase activity|toll-like receptor signaling pathway|regulation of cysteine-type endopeptidase activity involved in apoptotic process|receptor-mediated endocytosis|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to bacterial lipopeptide|regulation of endopeptidase activity|cellular response to diacyl bacterial lipopeptide|cellular response to triacyl bacterial lipopeptide|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|positive regulation of cysteine-type endopeptidase activity|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|regulation of cysteine-type endopeptidase activity|toll-like receptor 4 signaling pathway|activation of cysteine-type endopeptidase activity|toll-like receptor TLR1:TLR2 signaling pathway|TRIF-dependent toll-like receptor signaling pathway K04391 CD14 antigen[-] hsa04010|hsa04810|hsa05202|hsa05152|hsa04145|hsa04620|hsa05146|hsa04064|hsa04640|hsa05132|hsa05133|hsa05134|hsa05130 MAPK signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Legionellosis - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human) 5:140631728-140633701 59 37 37 9 6 21 1.08232517279927 0.616872562651307 0.6119695408977 0.147924173847378 0.0903021269344696 0.361032595029275 0.770389092116092 0.199752965270374 1.94737035664091 2.67344102005464e-05 0.000245276300592229 UP ENSG00000146072 TNFRSF21 tumor necrosis factor receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0002683|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0006950|GO:0071704|GO:0006955|GO:0051051|GO:0044237|GO:0051641|GO:0038023|GO:0051707|GO:0007155|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0002684|GO:0050793|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0060341|GO:0001818|GO:0002757|GO:0042127|GO:0002250|GO:0044255|GO:0016337|GO:0006959|GO:0045595|GO:0070661|GO:0048468|GO:0006810|GO:0010941|GO:0031641|GO:0007275|GO:0050877|GO:0070489|GO:0044281|GO:0032940|GO:0006952|GO:0030155|GO:0001817|GO:0098609|GO:0005887|GO:0004888|GO:0001816|GO:0032880|GO:0001775|GO:0043005|GO:0045184|GO:0031226|GO:0009617|GO:0007162|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0031645|GO:0007154|GO:0006629|GO:0007165|GO:0050778|GO:0008219|GO:0002695|GO:0008285|GO:0031642|GO:0051048|GO:1903531|GO:0048869|GO:0016021|GO:0010033|GO:0051224|GO:0032616|GO:0051249|GO:0032714|GO:0042113|GO:0032943|GO:0007166|GO:0033993|GO:0030424|GO:0034097|GO:0032613|GO:0007417|GO:0002237|GO:0050709|GO:0034109|GO:0050710|GO:0070997|GO:0051223|GO:0015031|GO:0005035|GO:0070201|GO:0006954|GO:0051250|GO:0002429|GO:0022408|GO:0022407|GO:0051046|GO:0032634|GO:0031644|GO:0007159|GO:0009306|GO:0070664|GO:0002764|GO:0032674|GO:0050663|GO:0042110|GO:0012501|GO:0032693|GO:0007399|GO:0046903|GO:0071310|GO:0046651|GO:0030154|GO:0050707|GO:0032496|GO:0043067|GO:0051960|GO:0097190|GO:0008366|GO:0032696|GO:1903038|GO:0042098|GO:0019221|GO:0005031|GO:0050863|GO:0010001|GO:0050869|GO:0050868|GO:0050708|GO:0002768|GO:0070486|GO:0050864|GO:2001180|GO:0048709|GO:0042981|GO:0071345|GO:2001179|GO:0051402|GO:0034612|GO:0042100|GO:0034111|GO:0032945|GO:0042552|GO:2000663|GO:2000666|GO:0022008|GO:0050851|GO:0050767|GO:0050672|GO:0006915|GO:0072608|GO:0048699|GO:0014013|GO:0071356|GO:0045685|GO:0042063|GO:0033209|GO:0030889|GO:0030888|GO:0042130|GO:0050852|GO:0042129|GO:0034349|GO:0071593|GO:0048713|GO:0097252|GO:0001783 developmental process|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of immune system process|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|response to stress|organic substance metabolic process|immune response|negative regulation of transport|cellular metabolic process|cellular localization|signaling receptor activity|response to other organism|cell adhesion|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of cellular localization|negative regulation of cytokine production|immune response-activating signal transduction|regulation of cell proliferation|adaptive immune response|cellular lipid metabolic process|single organismal cell-cell adhesion|humoral immune response|regulation of cell differentiation|leukocyte proliferation|cell development|transport|regulation of cell death|regulation of myelination|multicellular organism development|neurological system process|T cell aggregation|small molecule metabolic process|secretion by cell|defense response|regulation of cell adhesion|regulation of cytokine production|cell-cell adhesion|integral component of plasma membrane|transmembrane signaling receptor activity|cytokine production|regulation of protein localization|cell activation|neuron projection|establishment of protein localization|intrinsic component of plasma membrane|response to bacterium|negative regulation of cell adhesion|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|negative regulation of neurological system process|cell communication|lipid metabolic process|signal transduction|positive regulation of immune response|cell death|negative regulation of leukocyte activation|negative regulation of cell proliferation|negative regulation of myelination|negative regulation of secretion|negative regulation of secretion by cell|cellular developmental process|integral component of membrane|response to organic substance|negative regulation of protein transport|interleukin-13 production|regulation of lymphocyte activation|negative regulation of interleukin-5 production|B cell activation|mononuclear cell proliferation|cell surface receptor signaling pathway|response to lipid|axon|response to cytokine|interleukin-10 production|central nervous system development|response to molecule of bacterial origin|negative regulation of protein secretion|homotypic cell-cell adhesion|negative regulation of cytokine secretion|neuron death|regulation of protein transport|protein transport|death receptor activity|regulation of establishment of protein localization|inflammatory response|negative regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of secretion|interleukin-5 production|regulation of neurological system process|leukocyte cell-cell adhesion|protein secretion|negative regulation of leukocyte proliferation|immune response-regulating signaling pathway|regulation of interleukin-5 production|cytokine secretion|T cell activation|programmed cell death|negative regulation of interleukin-10 production|nervous system development|secretion|cellular response to organic substance|lymphocyte proliferation|cell differentiation|regulation of cytokine secretion|response to lipopolysaccharide|regulation of programmed cell death|regulation of nervous system development|apoptotic signaling pathway|axon ensheathment|negative regulation of interleukin-13 production|negative regulation of leukocyte cell-cell adhesion|T cell proliferation|cytokine-mediated signaling pathway|tumor necrosis factor-activated receptor activity|regulation of T cell activation|glial cell differentiation|negative regulation of B cell activation|negative regulation of T cell activation|regulation of protein secretion|immune response-regulating cell surface receptor signaling pathway|leukocyte aggregation|regulation of B cell activation|negative regulation of interleukin-10 secretion|oligodendrocyte differentiation|regulation of apoptotic process|cellular response to cytokine stimulus|regulation of interleukin-10 secretion|neuron apoptotic process|response to tumor necrosis factor|B cell proliferation|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|myelination|negative regulation of interleukin-5 secretion|negative regulation of interleukin-13 secretion|neurogenesis|antigen receptor-mediated signaling pathway|regulation of neurogenesis|negative regulation of lymphocyte proliferation|apoptotic process|interleukin-10 secretion|generation of neurons|regulation of gliogenesis|cellular response to tumor necrosis factor|regulation of glial cell differentiation|gliogenesis|tumor necrosis factor-mediated signaling pathway|negative regulation of B cell proliferation|regulation of B cell proliferation|negative regulation of T cell proliferation|T cell receptor signaling pathway|regulation of T cell proliferation|glial cell apoptotic process|lymphocyte aggregation|regulation of oligodendrocyte differentiation|oligodendrocyte apoptotic process|B cell apoptotic process K05157 tumor necrosis factor receptor superfamily member 21[-] hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) 6:47231532-47309905 1687 1965 3003 3976 4410 5850 33.1941734305389 35.1389988063034 53.2741355754596 70.0956345927079 71.1956453303678 107.877701678492 40.5357692707673 83.0563272005226 -1.03489455416348 2.68139624616746e-05 0.000245930579210702 DOWN ENSG00000075234 TTC38 tetratricopeptide repeat domain 38 [Source:HGNC Symbol;Acc:HGNC:26082] GO:0005576|GO:0005488|GO:1903561|GO:0043227|GO:0005515|GO:0031982|GO:0070062 extracellular region|binding|extracellular vesicle|membrane-bounded organelle|protein binding|vesicle|extracellular exosome - - - - 22:46267961-46294008 110 140 175 313 325 302 1.84428140057896 2.13325960916561 2.6453801213162 4.70195155835809 4.47082530838205 4.74539789217476 2.20764037702026 4.63939158630497 -1.07143044421862 2.69224977999533e-05 0.000246850199422545 DOWN ENSG00000163209 SPRR3 small proline-rich protein 3 [Source:HGNC Symbol;Acc:HGNC:11268] GO:0032502|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0009888|GO:0007275|GO:0048513|GO:0001533|GO:0031982|GO:0005737|GO:0009611|GO:0031424|GO:0070062|GO:0048869|GO:0019538|GO:0043412|GO:0036211|GO:0042060|GO:0043588|GO:0060429|GO:0044267|GO:0030154|GO:0030855|GO:0030216|GO:0008544|GO:0006464|GO:0018149|GO:0009913 developmental process|structural molecule activity|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|tissue development|multicellular organism development|animal organ development|cornified envelope|vesicle|cytoplasm|response to wounding|keratinization|extracellular exosome|cellular developmental process|protein metabolic process|macromolecule modification|protein modification process|wound healing|skin development|epithelium development|cellular protein metabolic process|cell differentiation|epithelial cell differentiation|keratinocyte differentiation|epidermis development|cellular protein modification process|peptide cross-linking|epidermal cell differentiation - - - - 1:153001747-153003856 92 87 73 42 37 32 2.24330199792336 1.92796473820645 1.60485959090985 0.917591069036543 0.74023077526305 0.731274015542429 1.92537544234655 0.796365286614007 1.27363755359283 2.70437897271077e-05 0.000247886183148011 UP ENSG00000164182 NDUFAF2 NADH:ubiquinone oxidoreductase complex assembly factor 2 [Source:HGNC Symbol;Acc:HGNC:28086] GO:0009055|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0005622|GO:0031090|GO:0060341|GO:0061179|GO:0019866|GO:0006810|GO:0061178|GO:0015980|GO:0044281|GO:0032940|GO:0043231|GO:0005737|GO:0007267|GO:0032880|GO:0042592|GO:0072593|GO:0031966|GO:0045184|GO:0046883|GO:0019725|GO:0010646|GO:0016651|GO:0008104|GO:0007154|GO:0051649|GO:0046888|GO:0051048|GO:1903531|GO:0006091|GO:0010817|GO:0022900|GO:0010033|GO:0051224|GO:0055114|GO:0005740|GO:0009743|GO:0090276|GO:0048878|GO:0050709|GO:0051223|GO:0015031|GO:0070201|GO:0042886|GO:0022904|GO:0055082|GO:0051046|GO:0005743|GO:0009914|GO:0009306|GO:0005739|GO:0016655|GO:0035773|GO:0002792|GO:0046903|GO:0071310|GO:0045333|GO:0003954|GO:0050796|GO:0071322|GO:0002790|GO:0030073|GO:0001678|GO:0046676|GO:0034284|GO:0050708|GO:0015833|GO:0046879|GO:0033500|GO:0071333|GO:0042593|GO:0030072|GO:0008137|GO:0009749 electron carrier activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|intracellular|organelle membrane|regulation of cellular localization|negative regulation of insulin secretion involved in cellular response to glucose stimulus|organelle inner membrane|transport|regulation of insulin secretion involved in cellular response to glucose stimulus|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|regulation of protein localization|homeostatic process|reactive oxygen species metabolic process|mitochondrial membrane|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|regulation of cell communication|oxidoreductase activity, acting on NAD(P)H|protein localization|cell communication|establishment of localization in cell|negative regulation of hormone secretion|negative regulation of secretion|negative regulation of secretion by cell|generation of precursor metabolites and energy|regulation of hormone levels|electron transport chain|response to organic substance|negative regulation of protein transport|oxidation-reduction process|mitochondrial envelope|response to carbohydrate|regulation of peptide hormone secretion|chemical homeostasis|negative regulation of protein secretion|regulation of protein transport|protein transport|regulation of establishment of protein localization|amide transport|respiratory electron transport chain|cellular chemical homeostasis|regulation of secretion|mitochondrial inner membrane|hormone transport|protein secretion|mitochondrion|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|insulin secretion involved in cellular response to glucose stimulus|negative regulation of peptide secretion|secretion|cellular response to organic substance|cellular respiration|NADH dehydrogenase activity|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|insulin secretion|cellular glucose homeostasis|negative regulation of insulin secretion|response to monosaccharide|regulation of protein secretion|peptide transport|hormone secretion|carbohydrate homeostasis|cellular response to glucose stimulus|glucose homeostasis|peptide hormone secretion|NADH dehydrogenase (ubiquinone) activity|response to glucose - - - - 5:60945129-61153037 54 75 87 200 211 138 2.03506189773447 2.5687682901375 2.95605948472548 6.75318150979362 6.5242685016225 4.87403363352772 2.51996322419915 6.05049454831461 -1.26365038904487 2.72660787971556e-05 0.000249693716690271 DOWN ENSG00000070778 PTPN21 protein tyrosine phosphatase, non-receptor type 21 [Source:HGNC Symbol;Acc:HGNC:9651] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0016787|GO:0005622|GO:0005515|GO:0016788|GO:0005737|GO:0019538|GO:0043412|GO:0036211|GO:0006796|GO:0044267|GO:0005856|GO:0042578|GO:0016311|GO:0016791|GO:0006464|GO:0006470|GO:0004721|GO:0035335|GO:0004725 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|hydrolase activity|intracellular|protein binding|hydrolase activity, acting on ester bonds|cytoplasm|protein metabolic process|macromolecule modification|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|cytoskeleton|phosphoric ester hydrolase activity|dephosphorylation|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity - - - - 14:88465778-88554733 33 27 26 86 74 88 0.18965769976542 0.14102921520903 0.134722343480729 0.442847007600881 0.348945316710775 0.473988524597271 0.15513641948506 0.421926949636309 -1.44345582935261 2.76181740014303e-05 0.000252685555206467 DOWN ENSG00000143512 HHIPL2 HHIP-like 2 [Source:HGNC Symbol;Acc:HGNC:25842] GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0071704|GO:0048037|GO:0005515|GO:0048038|GO:0016614|GO:0005975|GO:0055114|GO:0016901 extracellular region|metabolic process|binding|catalytic activity|oxidoreductase activity|organic substance metabolic process|cofactor binding|protein binding|quinone binding|oxidoreductase activity, acting on CH-OH group of donors|carbohydrate metabolic process|oxidation-reduction process|oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor - - - - 1:222522258-222548103 99 114 173 264 284 457 1.64272130099422 1.7191537501792 2.58815449867221 3.92492799068636 3.86649444742816 7.10682466388432 1.98334318328188 4.96608236733295 -1.32417385759596 2.77875058996572e-05 0.000254001286322219 DOWN ENSG00000008441 NFIX nuclear factor I/X (CCAAT-binding transcription factor) [Source:HGNC Symbol;Acc:HGNC:7788] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0010628|GO:0003705|GO:0006259|GO:0010467|GO:0031328|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0006260|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|DNA metabolic process|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|DNA replication|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 19:12995608-13098796 34 46 29 76 126 133 0.203595501746839 0.250335722986303 0.156567352385323 0.407750143357598 0.619049193497504 0.746392313827388 0.203499525706155 0.59106388356083 -1.53828863664556 2.78895848947659e-05 0.000254856341428938 DOWN ENSG00000080200 CRYBG3 crystallin beta-gamma domain containing 3 [Source:HGNC Symbol;Acc:HGNC:34427] GO:0005488|GO:0030246 binding|carbohydrate binding - - - - 3:97822040-97944963 317 352 563 759 855 978 1.94784281612893 1.96569929915153 3.1190186041847 4.17863378337217 4.31051188384859 5.63199864538781 2.34418690648839 4.70704810420286 -1.00573499371482 2.81628773352336e-05 0.000257274951030008 DOWN ENSG00000147905 ZCCHC7 zinc finger, CCHC domain containing 7 [Source:HGNC Symbol;Acc:HGNC:26209] GO:0005623|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0043231|GO:0043169|GO:0005737|GO:0005730|GO:0046872|GO:0003723|GO:0031981|GO:0005634|GO:0046914|GO:0044822|GO:0008270 cell|binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleolus|metal ion binding|RNA binding|nuclear lumen|nucleus|transition metal ion binding|poly(A) RNA binding|zinc ion binding K12597 protein AIR1/2[-] hsa03018 RNA degradation - Homo sapiens (human) 9:37120539-37358149 134 158 220 327 388 437 1.31430411282535 1.4084017926363 1.94548498301557 2.87366410998454 3.12241070957528 4.01699079327284 1.55606362949241 3.33768853761089 -1.10094827807596 2.82412895593366e-05 0.000257833473548756 DOWN ENSG00000138642 HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 [Source:HGNC Symbol;Acc:HGNC:26072] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016874|GO:0005622|GO:0002520|GO:0016740|GO:0048856|GO:0007275|GO:0048513|GO:0043231|GO:0005737|GO:0019787|GO:0048869|GO:0019538|GO:0005829|GO:0043412|GO:0030097|GO:0030163|GO:0004842|GO:0044265|GO:0036211|GO:0006508|GO:0044267|GO:0030154|GO:0005634|GO:0044257|GO:0051603|GO:0002244|GO:0006464|GO:0019941|GO:0032446|GO:0006511|GO:0042787|GO:0016567 developmental process|immune system process|cell|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|ligase activity|intracellular|immune system development|transferase activity|anatomical structure development|multicellular organism development|animal organ development|intracellular membrane-bounded organelle|cytoplasm|ubiquitin-like protein transferase activity|cellular developmental process|protein metabolic process|cytosol|macromolecule modification|hemopoiesis|protein catabolic process|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|protein modification process|proteolysis|cellular protein metabolic process|cell differentiation|nucleus|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|hematopoietic progenitor cell differentiation|cellular protein modification process|modification-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - 4:88378739-88443111 34 79 57 153 161 154 0.254720786076616 0.537886813059136 0.385008350061646 1.02699828412195 0.989638770176271 1.08126181843633 0.392538649732466 1.03263295757818 -1.39542093384218 2.82977561717738e-05 0.00025827001307005 DOWN ENSG00000241475 RP4-781K5.5 - - - - - - - 1:234660271-234667104 15 24 29 56 68 78 1.13723105540935 1.65369265798249 1.98234741021203 3.80407235751195 4.23002567697417 5.54225379444333 1.59109037453462 4.52545060964315 -1.50804566822917 2.86145843286695e-05 0.000261081846133282 DOWN ENSG00000065485 PDIA5 protein disulfide isomerase family A member 5 [Source:HGNC Symbol;Acc:HGNC:24811] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0016491|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0006457|GO:0043227|GO:0016853|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0033554|GO:0043231|GO:0005737|GO:0042592|GO:0019725|GO:0016860|GO:0007154|GO:0007165|GO:0005783|GO:0045454|GO:0019538|GO:0010033|GO:0055114|GO:0030968|GO:0006986|GO:0044267|GO:0005788|GO:0071310|GO:0035967|GO:0034976|GO:0034620|GO:0036498|GO:0003756 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|oxidoreductase activity|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|protein folding|membrane-bounded organelle|isomerase activity|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|cellular homeostasis|intramolecular oxidoreductase activity|cell communication|signal transduction|endoplasmic reticulum|cell redox homeostasis|protein metabolic process|response to organic substance|oxidation-reduction process|endoplasmic reticulum unfolded protein response|response to unfolded protein|cellular protein metabolic process|endoplasmic reticulum lumen|cellular response to organic substance|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|cellular response to unfolded protein|IRE1-mediated unfolded protein response|protein disulfide isomerase activity - - - - 3:123067062-123225227 165 162 317 464 472 593 2.12558752586284 1.89665688158974 3.68186885272358 5.35562808894384 4.98888848381569 7.15942144992077 2.56803775339205 5.8346460075601 -1.18397871712342 2.86359411585595e-05 0.00026113466568584 DOWN ENSG00000130590 SAMD10 sterile alpha motif domain containing 10 [Source:HGNC Symbol;Acc:HGNC:16129] GO:0005488|GO:0005515 binding|protein binding - - - - 20:63974113-63980008 84 99 104 222 275 185 2.03141344664665 2.17588831811479 2.26759561114427 4.81029075255829 5.45657133168337 4.19296214132878 2.1582991253019 4.81994140852348 -1.1591207828627 2.86466145280741e-05 0.00026113466568584 DOWN ENSG00000180596 HIST1H2BC histone cluster 1, H2bc [Source:HGNC Symbol;Acc:HGNC:4757] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0097159|GO:0043229|GO:0006950|GO:0006955|GO:0000785|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005615|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0045087|GO:0006959|GO:0003676|GO:0006952|GO:0031982|GO:0022607|GO:0098542|GO:0043231|GO:0005737|GO:0046983|GO:0009617|GO:0000790|GO:0070062|GO:0019730|GO:0000786|GO:0006996|GO:0051276|GO:0003677|GO:0002385|GO:0046982|GO:0006325|GO:0000788|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0002227|GO:0042742|GO:0005634|GO:0019731|GO:0006334|GO:0034622|GO:0034728|GO:0006333|GO:0050830|GO:0065004|GO:0031497|GO:0071103|GO:0006323 macromolecular complex|immune system process|cell|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|response to stress|immune response|chromatin|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|extracellular space|protein-DNA complex|intracellular|protein binding|protein complex|innate immune response|humoral immune response|nucleic acid binding|defense response|vesicle|cellular component assembly|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|response to bacterium|nuclear chromatin|extracellular exosome|antimicrobial humoral response|nucleosome|organelle organization|chromosome organization|DNA binding|mucosal immune response|protein heterodimerization activity|chromatin organization|nuclear nucleosome|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|innate immune response in mucosa|defense response to bacterium|nucleus|antibacterial humoral response|nucleosome assembly|cellular macromolecular complex assembly|nucleosome organization|chromatin assembly or disassembly|defense response to Gram-positive bacterium|protein-DNA complex assembly|chromatin assembly|DNA conformation change|DNA packaging K11252 histone H2B[-] hsa05203|hsa05034|hsa05322 Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 6:26114873-26123926 9 8 11 35 36 31 0.517589591063361 0.418128794010208 0.570345689257707 1.80344200318792 1.69865548898679 1.67084566968363 0.502021358110425 1.72431438728611 -1.78020219023716 2.88270165354587e-05 0.000262538667373271 DOWN ENSG00000221843 C2orf16 chromosome 2 open reading frame 16 [Source:HGNC Symbol;Acc:HGNC:25275] GO:0005623|GO:0005576|GO:1903561|GO:0043229|GO:0043227|GO:0005622|GO:0031982|GO:0043231|GO:0070062|GO:0005634 cell|extracellular region|extracellular vesicle|intracellular organelle|membrane-bounded organelle|intracellular|vesicle|intracellular membrane-bounded organelle|extracellular exosome|nucleus - - - - 2:27576522-27582720 4 8 10 24 27 45 0.045641918340484 0.0829647389308849 0.102884420062451 0.245374470777865 0.25278426981615 0.481240704266708 0.0771636924446066 0.326466481620241 -2.08094079144654 2.90432293962671e-05 0.00026426594647856 DOWN ENSG00000261441 RP11-217B1.2 - - - - - - - 15:89335053-89336161 20 17 7 3 2 2 0.822043881413247 0.635046228937857 0.259391626844931 0.110465135801558 0.0674423787447831 0.0770316622634725 0.572160579065345 0.0849797256032712 2.75122951138323 2.9102324826223e-05 0.000264722975430245 UP ENSG00000204947 ZNF425 zinc finger protein 425 [Source:HGNC Symbol;Acc:HGNC:20690] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:1903507|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription - - - - 7:149102784-149126346 183 198 123 84 80 62 2.83505727081225 2.78775422944717 1.71801725281596 1.16596567331099 1.0168817522743 0.900177361075632 2.44694291769179 1.02767492888697 1.25159645896887 2.91567309893043e-05 0.000265137084055648 UP ENSG00000177640 CASC2 cancer susceptibility candidate 2 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:22933] - - - - - - 10:118046279-118210153 10 13 13 50 38 36 0.0642506703135299 0.0759165547902419 0.0753094106440555 0.287847615034757 0.200333609467023 0.216783440875598 0.0718255452492758 0.234988221792459 -1.71001950221328 2.93165305739333e-05 0.000266427915906911 DOWN ENSG00000205744 DENND1C DENN/MADD domain containing 1C [Source:HGNC Symbol;Acc:HGNC:26225] GO:0005623|GO:0008152|GO:0043229|GO:0043227|GO:0009893|GO:0005622|GO:0005085|GO:0019222|GO:0031982|GO:0043231|GO:0005737|GO:0005088|GO:0043085|GO:0050790|GO:0005829|GO:0031410|GO:0051345|GO:0017112|GO:0016023|GO:0031988|GO:0043087|GO:0043547|GO:0030135|GO:0030136 cell|metabolic process|intracellular organelle|membrane-bounded organelle|positive regulation of metabolic process|intracellular|guanyl-nucleotide exchange factor activity|regulation of metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|Ras guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|regulation of catalytic activity|cytosol|cytoplasmic vesicle|positive regulation of hydrolase activity|Rab guanyl-nucleotide exchange factor activity|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|regulation of GTPase activity|positive regulation of GTPase activity|coated vesicle|clathrin-coated vesicle - - - - 19:6467207-6482557 224 354 347 140 152 188 1.60277634744354 2.30201344689365 2.2385612666248 0.897531739216734 0.892350251243372 1.26069911991906 2.04778368698733 1.01686037012639 1.00994173798551 2.93699664177517e-05 0.000266832312061947 UP ENSG00000101298 SNPH syntaphilin [Source:HGNC Symbol;Acc:HGNC:15931] GO:0032502|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0042995|GO:0043229|GO:0016079|GO:0051641|GO:0044297|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0016081|GO:0048856|GO:0097060|GO:0031090|GO:0051640|GO:0043025|GO:0006810|GO:0007275|GO:0048513|GO:0005874|GO:0032940|GO:0007420|GO:0043231|GO:0005737|GO:0007267|GO:0042734|GO:0060322|GO:0051656|GO:0022406|GO:0043005|GO:0031966|GO:0036477|GO:0000149|GO:0007154|GO:0051649|GO:0001505|GO:0048869|GO:0016021|GO:0016192|GO:0006836|GO:0051650|GO:0005740|GO:0048278|GO:0007417|GO:0048489|GO:0006887|GO:0046907|GO:0005739|GO:0007399|GO:0046903|GO:0051648|GO:0030154|GO:0005881|GO:0019905|GO:0005856|GO:0030182|GO:0045055|GO:0006904|GO:0016482|GO:0015630|GO:0017075|GO:0022008|GO:0048699|GO:0017156|GO:0007268 developmental process|synapse|signaling|cell|membrane|cellular process|cell junction|binding|cell projection|intracellular organelle|synaptic vesicle exocytosis|cellular localization|cell body|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|neurotransmitter secretion|protein binding|plasma membrane|synaptic vesicle docking|anatomical structure development|synaptic membrane|organelle membrane|organelle localization|neuronal cell body|transport|multicellular organism development|animal organ development|microtubule|secretion by cell|brain development|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|presynaptic membrane|head development|establishment of organelle localization|membrane docking|neuron projection|mitochondrial membrane|somatodendritic compartment|SNARE binding|cell communication|establishment of localization in cell|regulation of neurotransmitter levels|cellular developmental process|integral component of membrane|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|mitochondrial envelope|vesicle docking|central nervous system development|synaptic vesicle transport|exocytosis|intracellular transport|mitochondrion|nervous system development|secretion|vesicle localization|cell differentiation|cytoplasmic microtubule|syntaxin binding|cytoskeleton|neuron differentiation|regulated exocytosis|vesicle docking involved in exocytosis|cytosolic transport|microtubule cytoskeleton|syntaxin-1 binding|neurogenesis|generation of neurons|calcium ion regulated exocytosis|synaptic transmission - - - - 20:1266316-1309328 57 68 136 193 229 318 0.37305502779586 0.404472292873494 0.802518026137289 1.13176237830688 1.22971179711994 1.95055020971777 0.526681782268881 1.43734146171486 -1.44839937287789 2.94509522824373e-05 0.000267486683735894 DOWN ENSG00000128000 ZNF780B zinc finger protein 780B [Source:HGNC Symbol;Acc:HGNC:33109] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:40028260-40056209 25 55 32 94 110 142 0.137589548364388 0.275097801214245 0.158782456667011 0.463518850883554 0.496710754756003 0.732418472605057 0.190489935415215 0.564216026081538 -1.56653287047609 2.95311096309807e-05 0.000268133134709032 DOWN ENSG00000172301 COPRS coordinator of PRMT5, differentiation stimulator [Source:HGNC Symbol;Acc:HGNC:28848] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0032259|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0071944|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0006725|GO:0042393|GO:1901360|GO:0007275|GO:0016570|GO:0048513|GO:0034641|GO:0046483|GO:0061061|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0010468|GO:0034645|GO:0043412|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0036211|GO:0031981|GO:0005654|GO:0044267|GO:0010467|GO:0009059|GO:0007517|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0034969|GO:0016568|GO:0006464|GO:0018216|GO:0006351|GO:0006355|GO:0043985|GO:1903506|GO:0018193 developmental process|cell|membrane|cellular process|metabolic process|binding|methylation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|cell periphery|biosynthetic process|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|histone binding|organic cyclic compound metabolic process|multicellular organism development|histone modification|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|protein modification process|nuclear lumen|nucleoplasm|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|muscle organ development|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|histone arginine methylation|chromatin modification|cellular protein modification process|peptidyl-arginine methylation|transcription, DNA-templated|regulation of transcription, DNA-templated|histone H4-R3 methylation|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification - - - - 17:31851864-31859337 634 602 500 323 363 171 18.3124267041864 15.8027834630117 13.0209167080898 8.35906171938797 8.6026241573448 4.62893948329842 15.7120422917626 7.1968751200104 1.12642818796578 2.95439516869501e-05 0.000268168176850778 UP ENSG00000261286 RP11-517C16.2 - - - - - - - 16:84459259-84467361 10 13 22 50 52 43 0.235935833716361 0.278774300095321 0.467995462166097 1.05700947095318 1.00667417101728 0.950847109737788 0.327568531992593 1.00484358390275 -1.61710227024307 2.96113759605102e-05 0.000268698485691511 DOWN ENSG00000172339 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit [Source:HGNC Symbol;Acc:HGNC:28287] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0006486|GO:0044255|GO:0043231|GO:0005737|GO:0005975|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0019538|GO:0006490|GO:0034645|GO:0043412|GO:0006487|GO:0009100|GO:0036211|GO:0070085|GO:1901137|GO:0044267|GO:0009059|GO:0009101|GO:0043413|GO:0006488|GO:0018279|GO:0006464|GO:0018193|GO:0043687 cell|membrane|cellular process|metabolic process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|protein glycosylation|cellular lipid metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|protein metabolic process|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|macromolecule modification|protein N-linked glycosylation|glycoprotein metabolic process|protein modification process|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|cellular protein modification process|peptidyl-amino acid modification|post-translational protein modification K07441 beta-1,4-N-acetylglucosaminyltransferase[2.4.1.141] hsa01100|hsa00510 Metabolic pathways - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 1:94974407-95072945 27 30 23 83 92 62 0.194491404381243 0.196397053194713 0.149374930931522 0.535687420655516 0.543736464745733 0.418554972573456 0.180087796169159 0.499326285991568 -1.471282437466 2.97126487321265e-05 0.000269535525751718 DOWN ENSG00000083812 ZNF324 zinc finger protein 324 [Source:HGNC Symbol;Acc:HGNC:14096] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:58467045-58475436 720 465 277 111 258 181 4.4283584659455 2.59921971058388 1.53604786877579 0.611690307418181 1.30196167698733 1.04331803887709 2.85454201510172 0.985656674427534 1.5341021797831 2.97241286210188e-05 0.000269557756941645 UP ENSG00000248858 FLJ46284 uncharacterized LOC441369 [Source:EntrezGene;Acc:441369] - - - - - - 8:92699742-92879502 0 1 5 11 16 17 0 0.00768799028650961 0.0381134216838033 0.0833322160613386 0.110997464966185 0.134711774434857 0.0152671373234376 0.109680485154127 -2.84480537883513 2.98108006736084e-05 0.00027026165906769 DOWN ENSG00000245680 ZNF585B zinc finger protein 585B [Source:HGNC Symbol;Acc:HGNC:30948] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:37181579-37218153 143 94 136 58 45 62 0.766317913538207 0.457803514805495 0.657092032309987 0.278481910210024 0.197859161792889 0.311379532626616 0.62707115355123 0.26257353487651 1.25590764195879 2.99250579137657e-05 0.000271050570072076 UP ENSG00000198001 IRAK4 interleukin 1 receptor associated kinase 4 [Source:HGNC Symbol;Acc:HGNC:17967] GO:0040011|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0050900|GO:0043167|GO:0006955|GO:0044237|GO:0048870|GO:0023051|GO:0043227|GO:0071944|GO:0005615|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0031090|GO:0008284|GO:0002757|GO:0042127|GO:0045087|GO:0005102|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0002218|GO:0001816|GO:0006928|GO:0009966|GO:0010646|GO:0050776|GO:0007154|GO:0016477|GO:0007165|GO:0050778|GO:0010008|GO:0000166|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0005768|GO:0002443|GO:0000165|GO:1902533|GO:0005829|GO:0005126|GO:0048660|GO:0046872|GO:0007166|GO:0070851|GO:0035639|GO:0043412|GO:0002758|GO:0034097|GO:0001883|GO:0048659|GO:0048661|GO:0036211|GO:0032549|GO:0031098|GO:0002764|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0071310|GO:0017076|GO:1902531|GO:0016773|GO:0005634|GO:0045089|GO:0045088|GO:0019221|GO:0043122|GO:1990266|GO:0000287|GO:0005524|GO:0002446|GO:0030554|GO:0016310|GO:0002221|GO:0043123|GO:0007249|GO:0071345|GO:0004672|GO:0005149|GO:0006464|GO:0051403|GO:0002224|GO:0006468|GO:0007254|GO:0004674|GO:0034166|GO:0034134|GO:0038124|GO:0002755|GO:0034146|GO:0034142|GO:0038123|GO:0034162 locomotion|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|leukocyte migration|ion binding|immune response|cellular metabolic process|cell motility|regulation of signaling|membrane-bounded organelle|cell periphery|extracellular space|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|transferase activity|organelle membrane|positive regulation of cell proliferation|immune response-activating signal transduction|regulation of cell proliferation|innate immune response|receptor binding|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|activation of innate immune response|cytokine production|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|regulation of immune response|cell communication|cell migration|signal transduction|positive regulation of immune response|endosome membrane|nucleotide binding|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|endosome|leukocyte mediated immunity|MAPK cascade|positive regulation of intracellular signal transduction|cytosol|cytokine receptor binding|regulation of smooth muscle cell proliferation|metal ion binding|cell surface receptor signaling pathway|growth factor receptor binding|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|response to cytokine|purine nucleoside binding|smooth muscle cell proliferation|positive regulation of smooth muscle cell proliferation|protein modification process|ribonucleoside binding|stress-activated protein kinase signaling cascade|immune response-regulating signaling pathway|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|cellular response to organic substance|purine nucleotide binding|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|nucleus|positive regulation of innate immune response|regulation of innate immune response|cytokine-mediated signaling pathway|regulation of I-kappaB kinase/NF-kappaB signaling|neutrophil migration|magnesium ion binding|ATP binding|neutrophil mediated immunity|adenyl nucleotide binding|phosphorylation|pattern recognition receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|cellular response to cytokine stimulus|protein kinase activity|interleukin-1 receptor binding|cellular protein modification process|stress-activated MAPK cascade|toll-like receptor signaling pathway|protein phosphorylation|JNK cascade|protein serine/threonine kinase activity|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway K04733 interleukin-1 receptor-associated kinase 4[2.7.11.1] hsa05152|hsa05164|hsa05162|hsa04722|hsa05145|hsa04620|hsa05142|hsa04064|hsa05133|hsa05140 Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Measles - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human) 12:43758944-43789543 53 75 87 143 203 185 0.355427046703166 0.457108274610171 0.526026133184464 0.85923145533022 1.11696250672331 1.16272414328656 0.446187151499267 1.04630603511336 -1.22958401350697 3.0222020436735e-05 0.000273325718908902 DOWN ENSG00000236778 INTS6-AS1 INTS6 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:42691] - - - - - - 13:51452367-51552364 116 143 170 62 51 85 0.587870100851163 0.658626925201663 0.776758980228281 0.281522039346587 0.212060892472091 0.403710669480589 0.674418668760369 0.299097867099756 1.1730268499785 3.02366481691236e-05 0.000273375195166873 UP ENSG00000205213 LGR4 leucine-rich repeat containing G protein-coupled receptor 4 [Source:HGNC Symbol;Acc:HGNC:13299] GO:0032502|GO:0004871|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0006807|GO:0006950|GO:0007623|GO:0044702|GO:0071704|GO:0006955|GO:0019953|GO:0051051|GO:0044237|GO:0051641|GO:0038023|GO:0003006|GO:0023051|GO:0009653|GO:0071944|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0002684|GO:0050793|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0048609|GO:0019222|GO:0060341|GO:0001818|GO:0002757|GO:0048565|GO:0045087|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0006810|GO:0035295|GO:1901360|GO:0032835|GO:0007275|GO:0048513|GO:0072028|GO:0034641|GO:0032940|GO:0006952|GO:0031325|GO:0046483|GO:0032922|GO:0001817|GO:0005887|GO:0034122|GO:0048608|GO:0004888|GO:0001942|GO:0001763|GO:0002218|GO:0001816|GO:0007267|GO:0032880|GO:0009887|GO:0042592|GO:0009966|GO:0048729|GO:0072006|GO:0007548|GO:0050673|GO:0045184|GO:0048771|GO:0009890|GO:0010646|GO:0006139|GO:0031226|GO:0050776|GO:0008104|GO:0007154|GO:0007276|GO:0007165|GO:0050778|GO:0009968|GO:0001503|GO:0051048|GO:1903531|GO:0060688|GO:0048869|GO:0016021|GO:0048806|GO:0009967|GO:0044249|GO:0090184|GO:0051224|GO:0031324|GO:0031323|GO:0030111|GO:0007186|GO:0010468|GO:0034645|GO:2001013|GO:0072170|GO:0048232|GO:0055123|GO:0007166|GO:0002009|GO:0046661|GO:0072164|GO:0061458|GO:0002758|GO:0061005|GO:0001655|GO:0010629|GO:0030539|GO:0072273|GO:0072210|GO:0022405|GO:0051252|GO:0050709|GO:0050710|GO:0048754|GO:0051223|GO:0015031|GO:0061138|GO:0031214|GO:0001656|GO:0010628|GO:0070201|GO:2000027|GO:0048872|GO:0072001|GO:0001649|GO:0046849|GO:0051046|GO:0090189|GO:0009306|GO:0002764|GO:0043588|GO:0061326|GO:0050663|GO:0060993|GO:0060429|GO:0072073|GO:0010467|GO:0060562|GO:0046903|GO:0072224|GO:0031328|GO:0030177|GO:0009059|GO:0030154|GO:0001823|GO:0050707|GO:0034121|GO:0016070|GO:0004930|GO:0010557|GO:0030282|GO:0045089|GO:0045088|GO:0042633|GO:0072234|GO:0061290|GO:0016055|GO:0007283|GO:0072282|GO:0045893|GO:0072202|GO:0001657|GO:0060828|GO:0045892|GO:0036335|GO:0032774|GO:2001141|GO:0072078|GO:0050708|GO:0072163|GO:0001658|GO:1902679|GO:0008544|GO:0002221|GO:0061333|GO:0072080|GO:0072207|GO:0003338|GO:0090263|GO:0090190|GO:0006351|GO:0006355|GO:0098773|GO:1903507|GO:0002224|GO:1903506|GO:0060070|GO:0060675 developmental process|signal transducer activity|reproduction|immune system process|signaling|cell|rhythmic process|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|response to stress|circadian rhythm|single organism reproductive process|organic substance metabolic process|immune response|sexual reproduction|negative regulation of transport|cellular metabolic process|cellular localization|signaling receptor activity|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|cell periphery|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|regulation of cellular localization|negative regulation of cytokine production|immune response-activating signal transduction|digestive tract development|innate immune response|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|transport|tube development|organic cyclic compound metabolic process|glomerulus development|multicellular organism development|animal organ development|nephron morphogenesis|cellular nitrogen compound metabolic process|secretion by cell|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|circadian regulation of gene expression|regulation of cytokine production|integral component of plasma membrane|negative regulation of toll-like receptor signaling pathway|reproductive structure development|transmembrane signaling receptor activity|hair follicle development|morphogenesis of a branching structure|activation of innate immune response|cytokine production|cell-cell signaling|regulation of protein localization|organ morphogenesis|homeostatic process|regulation of signal transduction|tissue morphogenesis|nephron development|sex differentiation|epithelial cell proliferation|establishment of protein localization|tissue remodeling|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|regulation of immune response|protein localization|cell communication|gamete generation|signal transduction|positive regulation of immune response|negative regulation of signal transduction|ossification|negative regulation of secretion|negative regulation of secretion by cell|regulation of morphogenesis of a branching structure|cellular developmental process|integral component of membrane|genitalia development|positive regulation of signal transduction|cellular biosynthetic process|positive regulation of kidney development|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of Wnt signaling pathway|G-protein coupled receptor signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|epithelial cell proliferation involved in renal tubule morphogenesis|metanephric tubule development|male gamete generation|digestive system development|cell surface receptor signaling pathway|morphogenesis of an epithelium|male sex differentiation|mesonephric tubule development|reproductive system development|innate immune response-activating signal transduction|cell differentiation involved in kidney development|urogenital system development|negative regulation of gene expression|male genitalia development|metanephric nephron morphogenesis|metanephric nephron development|hair cycle process|regulation of RNA metabolic process|negative regulation of protein secretion|negative regulation of cytokine secretion|branching morphogenesis of an epithelial tube|regulation of protein transport|protein transport|morphogenesis of a branching epithelium|biomineral tissue development|metanephros development|positive regulation of gene expression|regulation of establishment of protein localization|regulation of organ morphogenesis|homeostasis of number of cells|renal system development|osteoblast differentiation|bone remodeling|regulation of secretion|regulation of branching involved in ureteric bud morphogenesis|protein secretion|immune response-regulating signaling pathway|skin development|renal tubule development|cytokine secretion|kidney morphogenesis|epithelium development|kidney epithelium development|gene expression|epithelial tube morphogenesis|secretion|metanephric glomerulus development|positive regulation of cellular biosynthetic process|positive regulation of Wnt signaling pathway|macromolecule biosynthetic process|cell differentiation|mesonephros development|regulation of cytokine secretion|regulation of toll-like receptor signaling pathway|RNA metabolic process|G-protein coupled receptor activity|positive regulation of macromolecule biosynthetic process|bone mineralization|positive regulation of innate immune response|regulation of innate immune response|hair cycle|metanephric nephron tubule development|canonical Wnt signaling pathway involved in metanephric kidney development|Wnt signaling pathway|spermatogenesis|metanephric nephron tubule morphogenesis|positive regulation of transcription, DNA-templated|cell differentiation involved in metanephros development|ureteric bud development|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|intestinal stem cell homeostasis|RNA biosynthetic process|regulation of RNA biosynthetic process|nephron tubule morphogenesis|regulation of protein secretion|mesonephric epithelium development|branching involved in ureteric bud morphogenesis|negative regulation of RNA biosynthetic process|epidermis development|pattern recognition receptor signaling pathway|renal tubule morphogenesis|nephron tubule development|metanephric epithelium development|metanephros morphogenesis|positive regulation of canonical Wnt signaling pathway|positive regulation of branching involved in ureteric bud morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|skin epidermis development|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|ureteric bud morphogenesis - - - - 11:27365961-27472775 877 1029 558 1745 2155 2017 7.8586543015984 8.3800006477497 4.50813510732377 14.0101136158503 15.8439651268204 16.9388309365915 6.91559668555729 15.5976365597541 -1.17340180127832 3.02596723568009e-05 0.000273500532406883 DOWN ENSG00000205885 C1RL-AS1 C1RL antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:27461] - - - - - - 12:7108052-7122501 70 126 117 231 254 270 0.710816564630814 1.16281941745087 1.0711836366252 2.10170773264262 2.11623118834954 2.56953887281033 0.981606539568961 2.26249259793416 -1.20469630668595 3.07435064891934e-05 0.000277789540777354 DOWN ENSG00000273033 RP11-67L2.2 - - - - - - - 3:122886941-122892416 27 50 85 131 152 250 0.348777500186962 0.586991436076237 0.989950246317806 1.51618027018648 1.61098878447626 3.02657995744002 0.641906394193668 2.05124967070092 -1.6760682649059 3.08093103840428e-05 0.000278215714520633 DOWN ENSG00000175274 TP53I11 tumor protein p53 inducible protein 11 [Source:HGNC Symbol;Acc:HGNC:16842] GO:0016020|GO:0009987|GO:0050896|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0031224|GO:0042127|GO:0008285|GO:0016021 membrane|cellular process|response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|intrinsic component of membrane|regulation of cell proliferation|negative regulation of cell proliferation|integral component of membrane - - - - 11:44885903-44951306 333 372 647 897 905 1075 1.32826039062793 1.34853598865059 2.32679025003028 3.20574790239514 2.96179957357364 4.01861576115642 1.6678622097696 3.3953877457084 -1.02557623080108 3.12986851734826e-05 0.000282378648283212 DOWN ENSG00000102781 KATNAL1 katanin p60 subunit A-like 1 [Source:HGNC Symbol;Acc:HGNC:28361] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0044877|GO:0043229|GO:0044702|GO:0043167|GO:0019953|GO:0032504|GO:0016787|GO:0005622|GO:0005515|GO:0048609|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0005737|GO:0032403|GO:0007276|GO:0008092|GO:0000166|GO:0007017|GO:0015631|GO:0048232|GO:0035639|GO:0001883|GO:0008017|GO:0016818|GO:0032549|GO:0051013|GO:0017076|GO:0005856|GO:0007283|GO:0005524|GO:0030554|GO:0015630|GO:0016462|GO:0017111|GO:0016887|GO:0042623|GO:0008568 reproduction|cell|cellular process|reproductive process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|single organism reproductive process|ion binding|sexual reproduction|multicellular organism reproduction|hydrolase activity|intracellular|protein binding|multicellular organismal reproductive process|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|cytoplasm|protein complex binding|gamete generation|cytoskeletal protein binding|nucleotide binding|microtubule-based process|tubulin binding|male gamete generation|purine ribonucleoside triphosphate binding|purine nucleoside binding|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|microtubule severing|purine nucleotide binding|cytoskeleton|spermatogenesis|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|ATPase activity, coupled|microtubule-severing ATPase activity - - - - 13:30202630-30307484 122 126 247 420 360 413 0.964341518088001 0.905151420489748 1.76027991718504 2.97452904680992 2.33475842231336 3.0595002974374 1.20992428525426 2.78959592218689 -1.2051393910761 3.13254164184494e-05 0.000282534435575948 DOWN ENSG00000181817 LSM10 LSM10, U7 small nuclear RNA associated [Source:HGNC Symbol;Acc:HGNC:17562] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0045787|GO:0006139|GO:0044249|GO:0034645|GO:0090068|GO:0003723|GO:1903047|GO:0030532|GO:0044770|GO:0000278|GO:0031981|GO:0007346|GO:0010564|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0045931|GO:0005634|GO:0017069|GO:0006396|GO:0032774|GO:0044772|GO:0016604|GO:1901990|GO:1901989|GO:1901992|GO:0016071|GO:0071208|GO:0005683|GO:1901987|GO:0006351|GO:1900087|GO:2000045|GO:0006366|GO:0015030|GO:1902808|GO:0008334|GO:1902806|GO:0006397|GO:0000082|GO:0071209|GO:0008380|GO:0006353|GO:0031123|GO:0031124|GO:0006369 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|positive regulation of cell cycle|nucleobase-containing compound metabolic process|cellular biosynthetic process|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|RNA binding|mitotic cell cycle process|small nuclear ribonucleoprotein complex|cell cycle phase transition|mitotic cell cycle|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|positive regulation of mitotic cell cycle|nucleus|snRNA binding|RNA processing|RNA biosynthetic process|mitotic cell cycle phase transition|nuclear body|regulation of mitotic cell cycle phase transition|positive regulation of cell cycle phase transition|positive regulation of mitotic cell cycle phase transition|mRNA metabolic process|histone pre-mRNA DCP binding|U7 snRNP|regulation of cell cycle phase transition|transcription, DNA-templated|positive regulation of G1/S transition of mitotic cell cycle|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|Cajal body|positive regulation of cell cycle G1/S phase transition|histone mRNA metabolic process|regulation of cell cycle G1/S phase transition|mRNA processing|G1/S transition of mitotic cell cycle|U7 snRNA binding|RNA splicing|DNA-templated transcription, termination|RNA 3'-end processing|mRNA 3'-end processing|termination of RNA polymerase II transcription - - - - 1:36391238-36397892 664 663 464 341 364 213 20.8104884399181 18.8845864878515 13.1113048942092 9.57560185179092 9.36016384090464 6.25636982021001 17.6021266073263 8.39737850430186 1.06773881672362 3.13946646371868e-05 0.000283073487791778 UP ENSG00000156194 PPEF2 protein phosphatase, EF-hand calcium binding domain 2 [Source:HGNC Symbol;Acc:HGNC:9244] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0051606|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0023057|GO:0016787|GO:0005622|GO:0005515|GO:0005929|GO:0019222|GO:0050877|GO:0016788|GO:0033554|GO:0043169|GO:0019899|GO:0005737|GO:0001917|GO:0009966|GO:0072372|GO:0010646|GO:0050906|GO:0007154|GO:0001750|GO:0007165|GO:0009968|GO:0050790|GO:0031072|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0000165|GO:0032268|GO:0046872|GO:0051879|GO:0043412|GO:0036211|GO:0032269|GO:0030544|GO:0007600|GO:0031098|GO:0019900|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:1902532|GO:0051246|GO:1902531|GO:0042578|GO:0031513|GO:0050953|GO:0016311|GO:0043408|GO:0016310|GO:0005509|GO:0032872|GO:0046914|GO:0016791|GO:0043409|GO:0019901|GO:0006464|GO:0051403|GO:0043549|GO:0006470|GO:0005506|GO:0045859|GO:0046328|GO:0030145|GO:0006468|GO:0043405|GO:0042325|GO:0004721|GO:0007254|GO:0001932|GO:0018193|GO:0042326|GO:0031435|GO:0001933|GO:0007601|GO:0004722|GO:0010801|GO:0071900|GO:0018107|GO:0043506 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|detection of stimulus|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|negative regulation of signaling|hydrolase activity|intracellular|protein binding|cilium|regulation of metabolic process|neurological system process|hydrolase activity, acting on ester bonds|cellular response to stress|cation binding|enzyme binding|cytoplasm|photoreceptor inner segment|regulation of signal transduction|primary cilium|regulation of cell communication|detection of stimulus involved in sensory perception|cell communication|photoreceptor outer segment|signal transduction|negative regulation of signal transduction|regulation of catalytic activity|heat shock protein binding|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|metal ion binding|Hsp90 protein binding|macromolecule modification|protein modification process|negative regulation of cellular protein metabolic process|Hsp70 protein binding|sensory perception|stress-activated protein kinase signaling cascade|kinase binding|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|negative regulation of intracellular signal transduction|regulation of protein metabolic process|regulation of intracellular signal transduction|phosphoric ester hydrolase activity|nonmotile primary cilium|sensory perception of light stimulus|dephosphorylation|regulation of MAPK cascade|phosphorylation|calcium ion binding|regulation of stress-activated MAPK cascade|transition metal ion binding|phosphatase activity|negative regulation of MAPK cascade|protein kinase binding|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|protein dephosphorylation|iron ion binding|regulation of protein kinase activity|regulation of JNK cascade|manganese ion binding|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|phosphoprotein phosphatase activity|JNK cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|mitogen-activated protein kinase kinase kinase binding|negative regulation of protein phosphorylation|visual perception|protein serine/threonine phosphatase activity|negative regulation of peptidyl-threonine phosphorylation|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|regulation of JUN kinase activity - - - - 4:75859864-75902571 9 11 6 1 1 0 0.0831985359393537 0.0924190731217504 0.0500089273366807 0.00827872366712128 0.00758798060433252 0 0.0752088454659283 0.00528890142381793 3.82986235884657 3.14607137444929e-05 0.000283583378057999 UP ENSG00000074660 SCARF1 scavenger receptor class F member 1 [Source:HGNC Symbol;Acc:HGNC:16820] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0044877|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0038023|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0031090|GO:0045595|GO:0048468|GO:0006810|GO:0070572|GO:0051130|GO:1901360|GO:0007275|GO:0016358|GO:0044281|GO:0031982|GO:0051128|GO:0033554|GO:0045597|GO:0043231|GO:0004888|GO:0005737|GO:0009611|GO:0012506|GO:0030666|GO:0007154|GO:0006629|GO:0007165|GO:0030030|GO:0048869|GO:0016021|GO:0038024|GO:0070570|GO:0016192|GO:0031175|GO:0031344|GO:0031102|GO:0031410|GO:0016042|GO:0010720|GO:0048678|GO:0006066|GO:0071813|GO:0031346|GO:0016023|GO:0050769|GO:0031988|GO:0048679|GO:0008202|GO:0030659|GO:0007399|GO:0030154|GO:0048469|GO:0048680|GO:0051960|GO:0005044|GO:0048666|GO:0030182|GO:0010975|GO:0042551|GO:0030139|GO:0046164|GO:0061564|GO:0006706|GO:0016125|GO:0030169|GO:0006897|GO:0022008|GO:0031103|GO:0050767|GO:0010976|GO:0045666|GO:0048699|GO:0016322|GO:0006898|GO:0008203|GO:0045664|GO:0006707 developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|macromolecular complex binding|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|signaling receptor activity|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|organelle membrane|regulation of cell differentiation|cell development|transport|positive regulation of neuron projection regeneration|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|dendrite development|small molecule metabolic process|vesicle|regulation of cellular component organization|cellular response to stress|positive regulation of cell differentiation|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|response to wounding|vesicle membrane|endocytic vesicle membrane|cell communication|lipid metabolic process|signal transduction|cell projection organization|cellular developmental process|integral component of membrane|cargo receptor activity|regulation of neuron projection regeneration|vesicle-mediated transport|neuron projection development|regulation of cell projection organization|neuron projection regeneration|cytoplasmic vesicle|lipid catabolic process|positive regulation of cell development|response to axon injury|alcohol metabolic process|lipoprotein particle binding|positive regulation of cell projection organization|cytoplasmic, membrane-bounded vesicle|positive regulation of neurogenesis|membrane-bounded vesicle|regulation of axon regeneration|steroid metabolic process|cytoplasmic vesicle membrane|nervous system development|cell differentiation|cell maturation|positive regulation of axon regeneration|regulation of nervous system development|scavenger receptor activity|neuron development|neuron differentiation|regulation of neuron projection development|neuron maturation|endocytic vesicle|alcohol catabolic process|axon development|steroid catabolic process|sterol metabolic process|low-density lipoprotein particle binding|endocytosis|neurogenesis|axon regeneration|regulation of neurogenesis|positive regulation of neuron projection development|positive regulation of neuron differentiation|generation of neurons|neuron remodeling|receptor-mediated endocytosis|cholesterol metabolic process|regulation of neuron differentiation|cholesterol catabolic process - - - - 17:1633858-1645747 58 54 59 17 17 32 0.364396965435675 0.308332384072276 0.334204187341282 0.0956961040243509 0.0876337169812114 0.18842045644272 0.335644512283078 0.123916759149427 1.43756273656397 3.15024978360177e-05 0.000283874304375633 UP ENSG00000223891 OSER1-AS1 OSER1 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:48585] - - - - - - 20:44210960-44226027 33 40 58 107 103 143 0.807160086000274 0.889174302615069 1.2790664825227 2.34492628464355 2.06706607947277 3.27802917488607 0.991800290379348 2.5633405130008 -1.36990358546367 3.15975825516034e-05 0.000284645211072893 DOWN ENSG00000239883 PARGP1 poly(ADP-ribose) glycohydrolase pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:45008] - - - - - - 10:45854093-45972154 44 45 56 138 99 152 0.892319177642505 0.829403388249999 1.02394041383665 2.50752209537929 1.64729366767396 2.88896290106662 0.915220993243051 2.34792622137329 -1.35919502551719 3.23291001595336e-05 0.000291059395706489 DOWN ENSG00000053747 LAMA3 laminin subunit alpha 3 [Source:HGNC Symbol;Acc:HGNC:6483] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0005198|GO:0009987|GO:0005576|GO:0005488|GO:0005604|GO:1903561|GO:0050794|GO:0040012|GO:0005578|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0043256|GO:0050793|GO:0005515|GO:0043234|GO:0005605|GO:0048856|GO:0048646|GO:0009888|GO:0007275|GO:0005102|GO:0043062|GO:0030155|GO:0031982|GO:0022607|GO:0006928|GO:0005610|GO:0048598|GO:0001704|GO:0051270|GO:0016477|GO:0070062|GO:0048869|GO:2000145|GO:0022617|GO:0007492|GO:0009790|GO:0030334|GO:0007369|GO:0034329|GO:0001706|GO:0060429|GO:0030198|GO:0030154|GO:0045995|GO:0035987|GO:0008544|GO:0007044|GO:0031581 locomotion|developmental process|extracellular matrix|macromolecular complex|structural molecule activity|cellular process|extracellular region|binding|basement membrane|extracellular vesicle|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|laminin complex|regulation of developmental process|protein binding|protein complex|basal lamina|anatomical structure development|anatomical structure formation involved in morphogenesis|tissue development|multicellular organism development|receptor binding|extracellular structure organization|regulation of cell adhesion|vesicle|cellular component assembly|movement of cell or subcellular component|laminin-5 complex|embryonic morphogenesis|formation of primary germ layer|regulation of cellular component movement|cell migration|extracellular exosome|cellular developmental process|regulation of cell motility|extracellular matrix disassembly|endoderm development|embryo development|regulation of cell migration|gastrulation|cell junction assembly|endoderm formation|epithelium development|extracellular matrix organization|cell differentiation|regulation of embryonic development|endodermal cell differentiation|epidermis development|cell-substrate junction assembly|hemidesmosome assembly K06240 laminin, alpha 3/5[-] hsa01100|hsa05200|hsa04151|hsa04510|hsa05145|hsa05146|hsa05222|hsa04512 Metabolic pathways - Homo sapiens (human)|Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 18:23689443-23955066 646 799 1304 1992 2239 1619 2.71773534048289 3.05493312924647 4.94614272965355 7.50864913707742 7.72852857497588 6.38337638074535 3.57293706646097 7.20685136426622 -1.01225858859672 3.24920511738773e-05 0.000292438256178756 DOWN ENSG00000108821 COL1A1 collagen, type I, alpha 1 [Source:HGNC Symbol;Acc:HGNC:2197] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0002376|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0005201|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0005578|GO:0006807|GO:0006950|GO:0071704|GO:0050900|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0005583|GO:0007155|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0005615|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0051272|GO:0050817|GO:0045595|GO:0044691|GO:0006725|GO:0009888|GO:0048468|GO:0019838|GO:0010718|GO:0006810|GO:0070849|GO:0051130|GO:0009612|GO:1901360|GO:0001568|GO:0005584|GO:0009991|GO:0007275|GO:0048513|GO:0050877|GO:0060325|GO:0034641|GO:0043062|GO:0030155|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0022607|GO:0030141|GO:0045597|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0031668|GO:0009611|GO:0060322|GO:0060351|GO:0071559|GO:0006928|GO:0009887|GO:0001775|GO:0031589|GO:0009966|GO:0045184|GO:0034505|GO:0006979|GO:0042493|GO:0044236|GO:0010646|GO:0006139|GO:0010171|GO:0007162|GO:0050776|GO:0008104|GO:0007154|GO:0051270|GO:0061383|GO:0016477|GO:0007165|GO:0005783|GO:0001503|GO:0060323|GO:0009725|GO:0060348|GO:0060324|GO:0048869|GO:2000145|GO:0010035|GO:0009967|GO:0044249|GO:0005581|GO:0010033|GO:0031323|GO:0050878|GO:0055093|GO:0005794|GO:0071774|GO:0007584|GO:0016192|GO:0030111|GO:0000902|GO:0048705|GO:0030574|GO:0044259|GO:0010468|GO:0034645|GO:0030168|GO:0051216|GO:0046872|GO:0007166|GO:0014074|GO:0060346|GO:2000736|GO:0033993|GO:0001944|GO:0022617|GO:0072358|GO:0034097|GO:0032964|GO:0031410|GO:0042542|GO:0010720|GO:0007596|GO:0051252|GO:0046683|GO:0010717|GO:0015031|GO:1901652|GO:0031214|GO:0000904|GO:0009790|GO:0061430|GO:0071417|GO:0010628|GO:0030334|GO:0043200|GO:0010812|GO:0016023|GO:0031670|GO:0071560|GO:0042060|GO:0033273|GO:0001649|GO:0071364|GO:0007600|GO:0060485|GO:0043434|GO:0043589|GO:0007599|GO:0044344|GO:0033197|GO:0010810|GO:0070848|GO:0031988|GO:0022604|GO:0051591|GO:0006461|GO:0043588|GO:0034613|GO:0014070|GO:0000302|GO:0032526|GO:0042476|GO:0048864|GO:0010467|GO:0005788|GO:0071310|GO:0060349|GO:0030198|GO:0031328|GO:0030177|GO:0071260|GO:0010770|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0030335|GO:0031669|GO:0016070|GO:0072359|GO:0031667|GO:0010557|GO:1902617|GO:0048545|GO:0097305|GO:2000738|GO:0048407|GO:0016055|GO:0048706|GO:0045893|GO:0050953|GO:0048863|GO:0033365|GO:0009792|GO:0050954|GO:0051259|GO:0010769|GO:0060828|GO:0060350|GO:0032774|GO:2001141|GO:0071306|GO:0014031|GO:0071363|GO:0043627|GO:0071407|GO:0001957|GO:0030199|GO:0071295|GO:0032355|GO:0071345|GO:0001958|GO:0048762|GO:0034612|GO:0071300|GO:0006897|GO:0090263|GO:0001837|GO:0071396|GO:0031960|GO:0071230|GO:0006351|GO:0006355|GO:0032963|GO:1902618|GO:0007605|GO:0051291|GO:0071356|GO:1903506|GO:0060070|GO:0070206|GO:0006898|GO:0043009|GO:0007601|GO:0034504|GO:0070208 locomotion|developmental process|extracellular matrix|macromolecular complex|immune system process|structural molecule activity|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|extracellular matrix structural constituent|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|response to stress|organic substance metabolic process|leukocyte migration|catabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|fibrillar collagen trimer|cell adhesion|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|extracellular space|regulation of developmental process|intracellular|regulation of immune system process|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|positive regulation of cellular component movement|coagulation|regulation of cell differentiation|tooth eruption|cellular aromatic compound metabolic process|tissue development|cell development|growth factor binding|positive regulation of epithelial to mesenchymal transition|transport|response to epidermal growth factor|positive regulation of cellular component organization|response to mechanical stimulus|organic cyclic compound metabolic process|blood vessel development|collagen type I trimer|response to extracellular stimulus|multicellular organism development|animal organ development|neurological system process|face morphogenesis|cellular nitrogen compound metabolic process|extracellular structure organization|regulation of cell adhesion|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|secretory granule|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|cellular response to extracellular stimulus|response to wounding|head development|cartilage development involved in endochondral bone morphogenesis|response to transforming growth factor beta|movement of cell or subcellular component|organ morphogenesis|cell activation|cell-substrate adhesion|regulation of signal transduction|establishment of protein localization|tooth mineralization|response to oxidative stress|response to drug|multicellular organism metabolic process|regulation of cell communication|nucleobase-containing compound metabolic process|body morphogenesis|negative regulation of cell adhesion|regulation of immune response|protein localization|cell communication|regulation of cellular component movement|trabecula morphogenesis|cell migration|signal transduction|endoplasmic reticulum|ossification|head morphogenesis|response to hormone|bone development|face development|cellular developmental process|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|collagen trimer|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|response to hyperoxia|Golgi apparatus|response to fibroblast growth factor|response to nutrient|vesicle-mediated transport|regulation of Wnt signaling pathway|cell morphogenesis|skeletal system morphogenesis|collagen catabolic process|multicellular organismal macromolecule metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|platelet activation|cartilage development|metal ion binding|cell surface receptor signaling pathway|response to purine-containing compound|bone trabecula formation|regulation of stem cell differentiation|response to lipid|vasculature development|extracellular matrix disassembly|cardiovascular system development|response to cytokine|collagen biosynthetic process|cytoplasmic vesicle|response to hydrogen peroxide|positive regulation of cell development|blood coagulation|regulation of RNA metabolic process|response to organophosphorus|regulation of epithelial to mesenchymal transition|protein transport|response to peptide|biomineral tissue development|cell morphogenesis involved in differentiation|embryo development|bone trabecula morphogenesis|cellular response to organonitrogen compound|positive regulation of gene expression|regulation of cell migration|response to amino acid|negative regulation of cell-substrate adhesion|cytoplasmic, membrane-bounded vesicle|cellular response to nutrient|cellular response to transforming growth factor beta stimulus|wound healing|response to vitamin|osteoblast differentiation|cellular response to epidermal growth factor stimulus|sensory perception|mesenchyme development|response to peptide hormone|skin morphogenesis|hemostasis|cellular response to fibroblast growth factor stimulus|response to vitamin E|regulation of cell-substrate adhesion|response to growth factor|membrane-bounded vesicle|regulation of cell morphogenesis|response to cAMP|protein complex assembly|skin development|cellular protein localization|response to organic cyclic compound|response to reactive oxygen species|response to retinoic acid|odontogenesis|stem cell development|gene expression|endoplasmic reticulum lumen|cellular response to organic substance|bone morphogenesis|extracellular matrix organization|positive regulation of cellular biosynthetic process|positive regulation of Wnt signaling pathway|cellular response to mechanical stimulus|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|positive regulation of cell migration|cellular response to nutrient levels|RNA metabolic process|circulatory system development|response to nutrient levels|positive regulation of macromolecule biosynthetic process|response to fluoride|response to steroid hormone|response to alcohol|positive regulation of stem cell differentiation|platelet-derived growth factor binding|Wnt signaling pathway|embryonic skeletal system development|positive regulation of transcription, DNA-templated|sensory perception of light stimulus|stem cell differentiation|protein localization to organelle|embryo development ending in birth or egg hatching|sensory perception of mechanical stimulus|protein oligomerization|regulation of cell morphogenesis involved in differentiation|regulation of canonical Wnt signaling pathway|endochondral bone morphogenesis|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to vitamin E|mesenchymal cell development|cellular response to growth factor stimulus|response to estrogen|cellular response to organic cyclic compound|intramembranous ossification|collagen fibril organization|cellular response to vitamin|response to estradiol|cellular response to cytokine stimulus|endochondral ossification|mesenchymal cell differentiation|response to tumor necrosis factor|cellular response to retinoic acid|endocytosis|positive regulation of canonical Wnt signaling pathway|epithelial to mesenchymal transition|cellular response to lipid|response to corticosteroid|cellular response to amino acid stimulus|transcription, DNA-templated|regulation of transcription, DNA-templated|collagen metabolic process|cellular response to fluoride|sensory perception of sound|protein heterooligomerization|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|protein trimerization|receptor-mediated endocytosis|chordate embryonic development|visual perception|protein localization to nucleus|protein heterotrimerization K06236 collagen, type I, alpha[-] hsa04151|hsa04510|hsa04611|hsa04933|hsa05146|hsa04974|hsa04512 PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 17:50183289-50201632 366 372 646 168 218 292 1.99504328705468 1.84287101970637 3.17481340958751 0.820497690427368 0.974980365769369 1.49170341525833 2.33757590544952 1.09572715715169 1.09312460974241 3.27535417862722e-05 0.000294702904306019 UP ENSG00000250271 RP11-64D22.5 - - - - - - - 3:151797484-151808249 8 8 17 31 49 38 1.450944880988 1.31871388880143 2.77998335837759 5.03771859870207 7.29199385462993 6.45933433680742 1.84988070938901 6.26301559671314 -1.75942523094361 3.31239764517667e-05 0.000297856383431037 DOWN ENSG00000137193 PIM1 Pim-1 proto-oncogene, serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:8986] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0043021|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0031668|GO:0009890|GO:0045787|GO:0060548|GO:0006139|GO:0043085|GO:0007154|GO:0044092|GO:0007165|GO:0008134|GO:0008219|GO:0050790|GO:0000166|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0051090|GO:0007584|GO:0043024|GO:0032268|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0035639|GO:1903047|GO:0043412|GO:0010629|GO:0043069|GO:0051252|GO:0001883|GO:0044770|GO:0051347|GO:0036211|GO:0031670|GO:0000278|GO:0032549|GO:0033273|GO:0045737|GO:0007346|GO:0010564|GO:0051247|GO:0043433|GO:0016301|GO:0032270|GO:0012501|GO:0014070|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0017076|GO:0051246|GO:0009059|GO:0031669|GO:0016070|GO:0031667|GO:0016773|GO:0005634|GO:0043067|GO:0097305|GO:0030522|GO:0033280|GO:1904031|GO:0031401|GO:0045892|GO:0031659|GO:0070561|GO:0032774|GO:0005524|GO:0044772|GO:2001141|GO:0030554|GO:0016310|GO:1902679|GO:0071407|GO:1901990|GO:0071295|GO:0042981|GO:0046914|GO:0043066|GO:0004672|GO:1901987|GO:0030203|GO:0006464|GO:0071396|GO:0000079|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0033674|GO:2000045|GO:0045859|GO:1903507|GO:0045860|GO:0030145|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:1902806|GO:0000082|GO:0004674|GO:0001934|GO:0042327|GO:0071305|GO:0030212|GO:0046777|GO:0071902|GO:0071900 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|ribonucleoprotein complex binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular response to extracellular stimulus|negative regulation of biosynthetic process|positive regulation of cell cycle|negative regulation of cell death|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|negative regulation of molecular function|signal transduction|transcription factor binding|cell death|regulation of catalytic activity|nucleotide binding|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|response to nutrient|ribosomal small subunit binding|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|negative regulation of gene expression|negative regulation of programmed cell death|regulation of RNA metabolic process|purine nucleoside binding|cell cycle phase transition|positive regulation of transferase activity|protein modification process|cellular response to nutrient|mitotic cell cycle|ribonucleoside binding|response to vitamin|positive regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|kinase activity|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|cellular response to nutrient levels|RNA metabolic process|response to nutrient levels|phosphotransferase activity, alcohol group as acceptor|nucleus|regulation of programmed cell death|response to alcohol|intracellular receptor signaling pathway|response to vitamin D|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein modification process|negative regulation of transcription, DNA-templated|positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle|vitamin D receptor signaling pathway|RNA biosynthetic process|ATP binding|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|regulation of mitotic cell cycle phase transition|cellular response to vitamin|regulation of apoptotic process|transition metal ion binding|negative regulation of apoptotic process|protein kinase activity|regulation of cell cycle phase transition|glycosaminoglycan metabolic process|cellular protein modification process|cellular response to lipid|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|regulation of G1/S transition of mitotic cell cycle|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|manganese ion binding|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|positive regulation of phosphorylation|cellular response to vitamin D|hyaluronan metabolic process|protein autophosphorylation|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity K04702 proto-oncogene serine/threonine-protein kinase Pim-1[2.7.11.1] hsa05206|hsa04630|hsa04933|hsa05221 MicroRNAs in cancer - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human) 6:37170203-37175426 1710 1838 3873 1150 1258 1417 31.9239970498861 31.1850735733114 65.1902755785526 19.2360897349702 19.2694744074937 24.7924722875544 42.7664487339167 21.0993454766728 1.01928116706232 3.31512054004596e-05 0.000298011468240084 UP ENSG00000137494 ANKRD42 ankyrin repeat domain 42 [Source:HGNC Symbol;Acc:HGNC:26752] GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003735|GO:0009058|GO:0005622|GO:0005515|GO:0034641|GO:0005737|GO:0030529|GO:0044249|GO:0019538|GO:0034645|GO:0006518|GO:0005840|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0043043|GO:0006412 macromolecular complex|structural molecule activity|cell|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|structural constituent of ribosome|biosynthetic process|intracellular|protein binding|cellular nitrogen compound metabolic process|cytoplasm|intracellular ribonucleoprotein complex|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|peptide metabolic process|ribosome|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|peptide biosynthetic process|translation - - - - 11:83193739-83260694 75 72 138 197 257 268 0.416588074945703 0.363461778538909 0.691100976088359 0.980417054979831 1.17124444597149 1.39511867273194 0.490383609857657 1.18226005789442 -1.26956474975176 3.40160263907317e-05 0.000305326052877001 DOWN ENSG00000107954 NEURL1 neuralized E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:7761] GO:0040011|GO:0032502|GO:0000003|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0045182|GO:0009987|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0048523|GO:0008283|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0044089|GO:0044702|GO:0045183|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0048870|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0071944|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0016874|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0097060|GO:0048646|GO:0048609|GO:0019222|GO:0042127|GO:0050804|GO:0045595|GO:0009888|GO:0048468|GO:0043025|GO:0006810|GO:0051130|GO:0010941|GO:0007275|GO:0048513|GO:0016358|GO:0034641|GO:0051491|GO:0031325|GO:0051128|GO:0045211|GO:0007420|GO:0022607|GO:0010942|GO:0050803|GO:0061061|GO:0045597|GO:0043169|GO:0010243|GO:0005737|GO:0007267|GO:0060322|GO:0030317|GO:0006928|GO:0048515|GO:0043005|GO:0009966|GO:0043204|GO:0043197|GO:0036477|GO:0014069|GO:0010646|GO:0043085|GO:0007154|GO:0060996|GO:0007276|GO:0060491|GO:0007165|GO:0009968|GO:0050808|GO:0008219|GO:0008285|GO:0019787|GO:0050790|GO:0030030|GO:0048869|GO:0007288|GO:0009967|GO:0044249|GO:0010469|GO:0007017|GO:0019538|GO:0010033|GO:0007281|GO:0031323|GO:0048732|GO:0050878|GO:0006996|GO:0032268|GO:0000902|GO:0060998|GO:0031175|GO:0031344|GO:0030879|GO:0010468|GO:0007286|GO:0034645|GO:0006518|GO:0048167|GO:0048232|GO:0046872|GO:0007166|GO:0043412|GO:0007010|GO:0050807|GO:0007176|GO:0044309|GO:0007589|GO:0050773|GO:0007417|GO:0004842|GO:0010720|GO:0090129|GO:0031346|GO:0035082|GO:0071417|GO:0043200|GO:0051347|GO:0036211|GO:0044782|GO:0060537|GO:0060999|GO:1901184|GO:0050769|GO:0030031|GO:0030425|GO:0051247|GO:0048471|GO:0008593|GO:0007595|GO:0070925|GO:0032270|GO:0012501|GO:0006796|GO:0043603|GO:0042384|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0007399|GO:0046903|GO:0071310|GO:0051246|GO:0009059|GO:0030154|GO:0048858|GO:1900006|GO:0043068|GO:0007517|GO:0000226|GO:0060074|GO:1901186|GO:0043067|GO:0051960|GO:0045746|GO:2000273|GO:0051489|GO:0048666|GO:0030182|GO:0060271|GO:0007283|GO:0060538|GO:0043043|GO:0010975|GO:0031401|GO:0061630|GO:0048168|GO:0045742|GO:0043065|GO:0097440|GO:0042058|GO:0048170|GO:0016310|GO:0045741|GO:0010608|GO:0006412|GO:0007167|GO:0046847|GO:0006417|GO:0001578|GO:0042981|GO:0090128|GO:0046914|GO:0007219|GO:0014706|GO:0022008|GO:0006464|GO:0050767|GO:0010976|GO:0043549|GO:0071230|GO:0006915|GO:0033674|GO:0045666|GO:0048169|GO:0045859|GO:0045860|GO:0006468|GO:0048699|GO:0007519|GO:0042325|GO:0001932|GO:0018193|GO:0001934|GO:0008270|GO:0045664|GO:0042327|GO:0007268|GO:0007169|GO:0032446|GO:0050731|GO:0050730|GO:0061097|GO:0061098|GO:0038127|GO:0018108|GO:0007173|GO:0016567|GO:0006513 locomotion|developmental process|reproduction|synapse|signaling|cell|membrane|translation regulator activity|cellular process|reproductive process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of cellular process|cell proliferation|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|single organism reproductive process|translation factor activity, non-nucleic acid binding|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|cell motility|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|cell periphery|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|ligase activity|regulation of developmental process|intracellular|protein binding|plasma membrane|transferase activity|anatomical structure development|synaptic membrane|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|regulation of cell proliferation|modulation of synaptic transmission|regulation of cell differentiation|tissue development|cell development|neuronal cell body|transport|positive regulation of cellular component organization|regulation of cell death|multicellular organism development|animal organ development|dendrite development|cellular nitrogen compound metabolic process|positive regulation of filopodium assembly|positive regulation of cellular metabolic process|regulation of cellular component organization|postsynaptic membrane|brain development|cellular component assembly|positive regulation of cell death|regulation of synapse structure or activity|muscle structure development|positive regulation of cell differentiation|cation binding|response to organonitrogen compound|cytoplasm|cell-cell signaling|head development|sperm motility|movement of cell or subcellular component|spermatid differentiation|neuron projection|regulation of signal transduction|perikaryon|dendritic spine|somatodendritic compartment|postsynaptic density|regulation of cell communication|positive regulation of catalytic activity|cell communication|dendritic spine development|gamete generation|regulation of cell projection assembly|signal transduction|negative regulation of signal transduction|synapse organization|cell death|negative regulation of cell proliferation|ubiquitin-like protein transferase activity|regulation of catalytic activity|cell projection organization|cellular developmental process|sperm axoneme assembly|positive regulation of signal transduction|cellular biosynthetic process|regulation of receptor activity|microtubule-based process|protein metabolic process|response to organic substance|germ cell development|regulation of cellular metabolic process|gland development|regulation of body fluid levels|organelle organization|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|neuron projection development|regulation of cell projection organization|mammary gland development|regulation of gene expression|spermatid development|cellular macromolecule biosynthetic process|peptide metabolic process|regulation of synaptic plasticity|male gamete generation|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|cytoskeleton organization|regulation of synapse organization|regulation of epidermal growth factor-activated receptor activity|neuron spine|body fluid secretion|regulation of dendrite development|central nervous system development|ubiquitin-protein transferase activity|positive regulation of cell development|positive regulation of synapse maturation|positive regulation of cell projection organization|axoneme assembly|cellular response to organonitrogen compound|response to amino acid|positive regulation of transferase activity|protein modification process|cilium organization|muscle tissue development|positive regulation of dendritic spine development|regulation of ERBB signaling pathway|positive regulation of neurogenesis|cell projection assembly|dendrite|positive regulation of protein metabolic process|perinuclear region of cytoplasm|regulation of Notch signaling pathway|lactation|organelle assembly|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|cellular amide metabolic process|cilium assembly|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|nervous system development|secretion|cellular response to organic substance|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of dendrite development|positive regulation of programmed cell death|muscle organ development|microtubule cytoskeleton organization|synapse maturation|positive regulation of ERBB signaling pathway|regulation of programmed cell death|regulation of nervous system development|negative regulation of Notch signaling pathway|positive regulation of receptor activity|regulation of filopodium assembly|neuron development|neuron differentiation|cilium morphogenesis|spermatogenesis|skeletal muscle organ development|peptide biosynthetic process|regulation of neuron projection development|positive regulation of protein modification process|ubiquitin protein ligase activity|regulation of neuronal synaptic plasticity|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of apoptotic process|apical dendrite|regulation of epidermal growth factor receptor signaling pathway|positive regulation of long-term neuronal synaptic plasticity|phosphorylation|positive regulation of epidermal growth factor-activated receptor activity|posttranscriptional regulation of gene expression|translation|enzyme linked receptor protein signaling pathway|filopodium assembly|regulation of translation|microtubule bundle formation|regulation of apoptotic process|regulation of synapse maturation|transition metal ion binding|Notch signaling pathway|striated muscle tissue development|neurogenesis|cellular protein modification process|regulation of neurogenesis|positive regulation of neuron projection development|regulation of kinase activity|cellular response to amino acid stimulus|apoptotic process|positive regulation of kinase activity|positive regulation of neuron differentiation|regulation of long-term neuronal synaptic plasticity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|generation of neurons|skeletal muscle tissue development|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|zinc ion binding|regulation of neuron differentiation|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|epidermal growth factor receptor signaling pathway|protein ubiquitination|protein monoubiquitination - - - - 10:103493979-103592552 630 745 1357 1754 1883 2538 8.36258186278097 8.98745192773135 16.2403040888891 20.8606298772921 20.5077618701448 31.57334899489 11.1967792931338 24.3139135807756 -1.11869832229303 3.4118803535864e-05 0.00030606453147827 DOWN ENSG00000102081 FMR1 fragile X mental retardation 1 [Source:HGNC Symbol;Acc:HGNC:3775] GO:0032991|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0043198|GO:0006810|GO:0003676|GO:0034641|GO:0005845|GO:0043231|GO:0006413|GO:0005737|GO:0030529|GO:0034518|GO:0043005|GO:0009890|GO:0043197|GO:0036477|GO:0006403|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0035770|GO:0005730|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0030424|GO:0044309|GO:0010629|GO:0005840|GO:0006446|GO:0032269|GO:0031981|GO:0005844|GO:0030425|GO:0005654|GO:0045947|GO:0050658|GO:0043603|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0005634|GO:0036464|GO:0043043|GO:0051028|GO:0017148|GO:0010608|GO:0006412|GO:0006417|GO:0042788|GO:0044822|GO:0003729 macromolecular complex|synapse|cell|membrane|cellular process|metabolic process|binding|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|dendritic shaft|transport|nucleic acid binding|cellular nitrogen compound metabolic process|mRNA cap binding complex|intracellular membrane-bounded organelle|translational initiation|cytoplasm|intracellular ribonucleoprotein complex|RNA cap binding complex|neuron projection|negative regulation of biosynthetic process|dendritic spine|somatodendritic compartment|RNA localization|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|ribonucleoprotein granule|nucleolus|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|axon|neuron spine|negative regulation of gene expression|ribosome|regulation of translational initiation|negative regulation of cellular protein metabolic process|nuclear lumen|polysome|dendrite|nucleoplasm|negative regulation of translational initiation|RNA transport|cellular amide metabolic process|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|cytoplasmic ribonucleoprotein granule|peptide biosynthetic process|mRNA transport|negative regulation of translation|posttranscriptional regulation of gene expression|translation|regulation of translation|polysomal ribosome|poly(A) RNA binding|mRNA binding K15516 fragile X mental retardation protein[-] hsa03013 RNA transport - Homo sapiens (human) X:147911951-147951125 1510 3369 3526 1623 1041 1406 5.15778886585043 10.4584574110921 10.8588313045189 4.96709784819819 2.91746213866627 4.50091572657484 8.82502586048714 4.12849190447977 1.09598562974943 3.41501000775534e-05 0.000306253255546795 UP ENSG00000128656 CHN1 chimerin 1 [Source:HGNC Symbol;Acc:HGNC:1943] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0050794|GO:0043167|GO:0023051|GO:0009653|GO:0016043|GO:0009605|GO:0009893|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0035591|GO:0006935|GO:0045595|GO:0048468|GO:0007275|GO:0005102|GO:0008047|GO:0051128|GO:0043169|GO:0005737|GO:0006928|GO:0009966|GO:0030674|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0000902|GO:0005829|GO:0031175|GO:0031344|GO:0005096|GO:0046872|GO:0007166|GO:0051345|GO:0030695|GO:0000904|GO:0022604|GO:0046875|GO:0035556|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:1902531|GO:0005070|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0010769|GO:0043087|GO:0061564|GO:0043547|GO:0007167|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0050767|GO:0048812|GO:0007409|GO:0008045|GO:0048699|GO:0050770|GO:0045664|GO:0007169|GO:0048013 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|binding, bridging|cellular response to stimulus|regulation of cellular process|ion binding|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|signaling adaptor activity|chemotaxis|regulation of cell differentiation|cell development|multicellular organism development|receptor binding|enzyme activator activity|regulation of cellular component organization|cation binding|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|protein binding, bridging|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|cell morphogenesis|cytosol|neuron projection development|regulation of cell projection organization|GTPase activator activity|metal ion binding|cell surface receptor signaling pathway|positive regulation of hydrolase activity|GTPase regulator activity|cell morphogenesis involved in differentiation|regulation of cell morphogenesis|ephrin receptor binding|intracellular signal transduction|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|SH3/SH2 adaptor activity|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|regulation of GTPase activity|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|regulation of neurogenesis|neuron projection morphogenesis|axonogenesis|motor neuron axon guidance|generation of neurons|regulation of axonogenesis|regulation of neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|ephrin receptor signaling pathway - - - - 2:174799363-175005369 0 0 1 9 12 4 0 0 0.00571649877319025 0.0511519697206968 0.0624579072968849 0.0237775070855414 0.00190549959106342 0.045795794701041 -4.58697392213052 3.42405889244305e-05 0.00030696791392065 DOWN ENSG00000273373 RP5-1074L1.4 - - - - - - - 1:110370154-110373003 62 58 81 161 149 177 1.53883497741506 1.30830298967931 1.81258082135068 3.58033846299443 3.03428110306554 4.11721325740861 1.55323959614835 3.57727760782286 -1.20358168937564 3.46599050203765e-05 0.000310358969549586 DOWN ENSG00000273328 RP11-141M3.6 - - - - - - - 3:42809414-42908105 27 24 32 74 66 110 0.437149368510827 0.353146086037461 0.467116254415448 1.07348474627642 0.876755693018341 1.66911162950428 0.419137236321245 1.20645068959968 -1.52527434862658 3.52046099692337e-05 0.000314778038834902 DOWN ENSG00000257588 RP11-469H8.6 - - - - - - - 12:49951512-49962924 0 0 1 10 5 9 0 0 0.0308243122919944 0.306483813379278 0.140328769450627 0.288511714289103 0.0102747707639981 0.245108099039669 -4.57624004354016 3.52634894402959e-05 0.000315196471182813 DOWN ENSG00000174469 CNTNAP2 contactin associated protein-like 2 [Source:HGNC Symbol;Acc:HGNC:13830] GO:0032502|GO:0032991|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0042995|GO:0043229|GO:0009628|GO:0009986|GO:0051641|GO:0016043|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0009605|GO:0031252|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0071625|GO:0021794|GO:0021544|GO:0048468|GO:0030534|GO:0009612|GO:0098797|GO:0007275|GO:0007638|GO:0048513|GO:0050877|GO:0030900|GO:0007420|GO:0005887|GO:0043231|GO:0019899|GO:0005737|GO:0071109|GO:0060322|GO:0021987|GO:0043005|GO:0008037|GO:0031226|GO:0008104|GO:0021756|GO:1902495|GO:0007154|GO:0035176|GO:0061024|GO:0032589|GO:0007611|GO:0031256|GO:0021543|GO:0030030|GO:0031253|GO:0048869|GO:0016021|GO:0021537|GO:0021536|GO:0005794|GO:0005768|GO:0031175|GO:0044224|GO:0030424|GO:0007417|GO:0007612|GO:0005769|GO:0021761|GO:0031223|GO:0044304|GO:0045161|GO:0008076|GO:0019226|GO:0030673|GO:0008038|GO:0034702|GO:0034613|GO:0007399|GO:0050890|GO:0030154|GO:0010996|GO:0048469|GO:0048666|GO:0030182|GO:0042551|GO:0034703|GO:0022008|GO:0071205|GO:0098597|GO:0042297|GO:0045163|GO:0048699|GO:0034705 developmental process|macromolecular complex|behavior|signaling|cell|membrane|cellular process|response to stimulus|binding|cell projection|intracellular organelle|response to abiotic stimulus|cell surface|cellular localization|cellular component organization|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|response to external stimulus|cell leading edge|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|vocalization behavior|thalamus development|subpallium development|cell development|adult behavior|response to mechanical stimulus|plasma membrane protein complex|multicellular organism development|mechanosensory behavior|animal organ development|neurological system process|forebrain development|brain development|integral component of plasma membrane|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|superior temporal gyrus development|head development|cerebral cortex development|neuron projection|cell recognition|intrinsic component of plasma membrane|protein localization|striatum development|transmembrane transporter complex|cell communication|social behavior|membrane organization|neuron projection membrane|learning or memory|leading edge membrane|pallium development|cell projection organization|cell projection membrane|cellular developmental process|integral component of membrane|telencephalon development|diencephalon development|Golgi apparatus|endosome|neuron projection development|juxtaparanode region of axon|axon|central nervous system development|learning|early endosome|limbic system development|auditory behavior|main axon|neuronal ion channel clustering|voltage-gated potassium channel complex|transmission of nerve impulse|axolemma|neuron recognition|ion channel complex|cellular protein localization|nervous system development|cognition|cell differentiation|response to auditory stimulus|cell maturation|neuron development|neuron differentiation|neuron maturation|cation channel complex|neurogenesis|protein localization to juxtaparanode region of axon|observational learning|vocal learning|clustering of voltage-gated potassium channels|generation of neurons|potassium channel complex K07380 contactin associated protein-like 2[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 7:146116002-148420998 0 0 5 12 14 14 0 0 0.0245444450624816 0.0585459342069138 0.0625461056183 0.0714449594941773 0.00818148168749387 0.0641789997731304 -2.97166725771198 3.53144959920269e-05 0.000315557905820404 DOWN ENSG00000146414 SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:19336] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0016787|GO:0032993|GO:0016874|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0022607|GO:0043231|GO:0043169|GO:0006139|GO:0019787|GO:0000166|GO:0000786|GO:0019538|GO:0006996|GO:0051276|GO:0003677|GO:0046872|GO:0035639|GO:0043412|GO:0004842|GO:0006325|GO:0001883|GO:0016818|GO:0036211|GO:0032549|GO:0006259|GO:0005694|GO:0006461|GO:0044267|GO:0017076|GO:0005634|GO:0006974|GO:0006334|GO:0034622|GO:0005524|GO:0034728|GO:0030554|GO:0006333|GO:0065004|GO:0031497|GO:0046914|GO:0006464|GO:0071103|GO:0016462|GO:0006323|GO:0017111|GO:0008270|GO:0032446|GO:0004386|GO:0016567|GO:0000209 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|hydrolase activity|protein-DNA complex|ligase activity|intracellular|protein binding|protein complex|transferase activity|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|ubiquitin-like protein transferase activity|nucleotide binding|nucleosome|protein metabolic process|organelle organization|chromosome organization|DNA binding|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|ubiquitin-protein transferase activity|chromatin organization|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|ribonucleoside binding|DNA metabolic process|chromosome|protein complex assembly|cellular protein metabolic process|purine nucleotide binding|nucleus|cellular response to DNA damage stimulus|nucleosome assembly|cellular macromolecular complex assembly|ATP binding|nucleosome organization|adenyl nucleotide binding|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|transition metal ion binding|cellular protein modification process|DNA conformation change|pyrophosphatase activity|DNA packaging|nucleoside-triphosphatase activity|zinc ion binding|protein modification by small protein conjugation|helicase activity|protein ubiquitination|protein polyubiquitination - - - - 6:145864245-145964423 126 165 228 365 398 374 0.328474478409456 0.3909278126227 0.535895753118901 0.852554349666253 0.851299760689753 0.913760282607955 0.418432681383686 0.872538130987987 -1.06022264360095 3.53391747370025e-05 0.00031568393853934 DOWN ENSG00000104728 ARHGEF10 Rho guanine nucleotide exchange factor 10 [Source:HGNC Symbol;Acc:HGNC:14103] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0044089|GO:0023051|GO:0016043|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0048856|GO:0019222|GO:0007049|GO:0048468|GO:0022402|GO:0051130|GO:0007275|GO:0051128|GO:0022607|GO:0005737|GO:0032970|GO:0005088|GO:0009966|GO:0032231|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0032233|GO:0008092|GO:0050790|GO:0048869|GO:0030029|GO:0007017|GO:0006996|GO:0051017|GO:0031023|GO:0005829|GO:0005813|GO:0032956|GO:1903047|GO:0007010|GO:0021782|GO:0051345|GO:0005815|GO:0007098|GO:0000278|GO:0007051|GO:0006461|GO:0030036|GO:0070925|GO:0035556|GO:0033043|GO:0007067|GO:0051298|GO:0019894|GO:0007399|GO:0030154|GO:0051496|GO:0005089|GO:1902531|GO:0000226|GO:0005856|GO:0051492|GO:0008366|GO:0007422|GO:0010638|GO:0051225|GO:0014044|GO:0010001|GO:0043087|GO:0007052|GO:0043547|GO:0051493|GO:0015630|GO:0051297|GO:0042552|GO:0031032|GO:0051056|GO:0022008|GO:0030038|GO:0007264|GO:0007015|GO:0051495|GO:0090307|GO:0014037|GO:0007265|GO:0046578|GO:0090630|GO:0022011|GO:0043149|GO:0042063|GO:0061572|GO:0035023|GO:0007266 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|regulation of signaling|cellular component organization|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|cell cycle|cell development|cell cycle process|positive regulation of cellular component organization|multicellular organism development|regulation of cellular component organization|cellular component assembly|cytoplasm|regulation of actin filament-based process|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|regulation of actin filament bundle assembly|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|positive regulation of actin filament bundle assembly|cytoskeletal protein binding|regulation of catalytic activity|cellular developmental process|actin filament-based process|microtubule-based process|organelle organization|actin filament bundle assembly|microtubule organizing center organization|cytosol|centrosome|regulation of actin cytoskeleton organization|mitotic cell cycle process|cytoskeleton organization|glial cell development|positive regulation of hydrolase activity|microtubule organizing center|centrosome cycle|mitotic cell cycle|spindle organization|protein complex assembly|actin cytoskeleton organization|organelle assembly|intracellular signal transduction|regulation of organelle organization|mitotic nuclear division|centrosome duplication|kinesin binding|nervous system development|cell differentiation|positive regulation of stress fiber assembly|Rho guanyl-nucleotide exchange factor activity|regulation of intracellular signal transduction|microtubule cytoskeleton organization|cytoskeleton|regulation of stress fiber assembly|axon ensheathment|peripheral nervous system development|positive regulation of organelle organization|spindle assembly|Schwann cell development|glial cell differentiation|regulation of GTPase activity|mitotic spindle organization|positive regulation of GTPase activity|regulation of cytoskeleton organization|microtubule cytoskeleton|centrosome organization|myelination|actomyosin structure organization|regulation of small GTPase mediated signal transduction|neurogenesis|contractile actin filament bundle assembly|small GTPase mediated signal transduction|actin filament organization|positive regulation of cytoskeleton organization|mitotic spindle assembly|Schwann cell differentiation|Ras protein signal transduction|regulation of Ras protein signal transduction|activation of GTPase activity|myelination in peripheral nervous system|stress fiber assembly|gliogenesis|actin filament bundle organization|regulation of Rho protein signal transduction|Rho protein signal transduction - - - - 8:1823976-1958641 222 293 582 757 909 909 0.864972726242386 1.03752189114983 2.04449968521812 2.6426698104636 2.9059041754555 3.31926674969093 1.31566476753678 2.95594691187001 -1.16782842322761 3.5694025711829e-05 0.000318567845620611 DOWN ENSG00000206149 HERC2P9 hect domain and RLD 2 pseudogene 9 [Source:HGNC Symbol;Acc:HGNC:30495] - - - - - - 15:28589492-28685264 94 107 101 209 255 228 0.645561769113787 0.667841917195952 0.62538023114405 1.28603703169419 1.43686695976963 1.46748096100782 0.64626130581793 1.39679498415721 -1.11193076387917 3.58429092359901e-05 0.000319705471267179 DOWN ENSG00000179921 GPBAR1 G protein-coupled bile acid receptor 1 [Source:HGNC Symbol;Acc:HGNC:19680] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0016043|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0051128|GO:0022607|GO:0004888|GO:0005737|GO:1901888|GO:0007154|GO:0007165|GO:0038181|GO:0016021|GO:0007186|GO:0045216|GO:0007166|GO:0038182|GO:0034329|GO:2000810|GO:0038183|GO:0004930|GO:0038184|GO:0007043|GO:0070830|GO:0043297 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|cellular component organization|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|regulation of cellular component organization|cellular component assembly|transmembrane signaling receptor activity|cytoplasm|regulation of cell junction assembly|cell communication|signal transduction|bile acid receptor activity|integral component of membrane|G-protein coupled receptor signaling pathway|cell-cell junction organization|cell surface receptor signaling pathway|G-protein coupled bile acid receptor activity|cell junction assembly|regulation of bicellular tight junction assembly|bile acid signaling pathway|G-protein coupled receptor activity|cell surface bile acid receptor signaling pathway|cell-cell junction assembly|bicellular tight junction assembly|apical junction assembly - - - - 2:218259496-218263859 20 20 11 4 4 3 0.265081041767322 0.240911755964285 0.131445605731119 0.0475029811555816 0.0434957218736262 0.0372601154455976 0.212479467820909 0.0427529394916018 2.31322791694161 3.59056173030036e-05 0.000319882512373581 UP ENSG00000183091 NEB nebulin [Source:HGNC Symbol;Acc:HGNC:7720] GO:0032502|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0008307|GO:0005622|GO:0005515|GO:0048856|GO:0030017|GO:0030018|GO:0007275|GO:0048513|GO:0032535|GO:0031982|GO:0051128|GO:0061061|GO:0005737|GO:0032970|GO:0003012|GO:0006928|GO:0031674|GO:0070062|GO:0008092|GO:0030029|GO:0006996|GO:0005829|GO:0006936|GO:0032956|GO:0007010|GO:0030048|GO:0003779|GO:0043292|GO:0030036|GO:0033043|GO:0030832|GO:0007517|GO:0005856|GO:0007525|GO:0015629|GO:0070252|GO:0030016|GO:0051493|GO:0030049|GO:0033275 developmental process|structural molecule activity|cell|cellular process|extracellular region|binding|extracellular vesicle|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|structural constituent of muscle|intracellular|protein binding|anatomical structure development|sarcomere|Z disc|multicellular organism development|animal organ development|regulation of cellular component size|vesicle|regulation of cellular component organization|muscle structure development|cytoplasm|regulation of actin filament-based process|muscle system process|movement of cell or subcellular component|I band|extracellular exosome|cytoskeletal protein binding|actin filament-based process|organelle organization|cytosol|muscle contraction|regulation of actin cytoskeleton organization|cytoskeleton organization|actin filament-based movement|actin binding|contractile fiber|actin cytoskeleton organization|regulation of organelle organization|regulation of actin filament length|muscle organ development|cytoskeleton|somatic muscle development|actin cytoskeleton|actin-mediated cell contraction|myofibril|regulation of cytoskeleton organization|muscle filament sliding|actin-myosin filament sliding - - - - 2:151485336-151734487 7 8 10 31 31 31 0.014446495247742 0.0150046217946247 0.0186072038734723 0.0573202898090153 0.0524916699025205 0.0599585766632883 0.0160194403052797 0.056590178791608 -1.8207279524228 3.58989031837525e-05 0.000319882512373581 DOWN ENSG00000182511 FES FES proto-oncogene, tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:3657] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0019898|GO:0097159|GO:0030055|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006950|GO:0044089|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0031224|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0012505|GO:0016740|GO:0048856|GO:0060341|GO:0042127|GO:1903706|GO:0009898|GO:0008360|GO:0006935|GO:0045087|GO:0045595|GO:0051640|GO:0048468|GO:0006810|GO:0051130|GO:0007275|GO:0060627|GO:0048513|GO:0005102|GO:0043168|GO:0005924|GO:0032940|GO:0006952|GO:0030155|GO:0005912|GO:0005543|GO:0001882|GO:0016772|GO:0031982|GO:0051128|GO:0022607|GO:0045597|GO:0043231|GO:0005737|GO:0032970|GO:0032886|GO:0006928|GO:0032403|GO:0031234|GO:0051656|GO:0001775|GO:0098562|GO:0002263|GO:0019897|GO:0050776|GO:0050865|GO:0007154|GO:0051270|GO:0007165|GO:0002366|GO:0051649|GO:0008092|GO:0000166|GO:0030030|GO:0043299|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0007017|GO:0019538|GO:0031334|GO:0043254|GO:0005794|GO:0002443|GO:0006996|GO:0016192|GO:0031023|GO:0015631|GO:0000902|GO:0005829|GO:0031175|GO:0031344|GO:0007166|GO:0032956|GO:0035639|GO:0043412|GO:0007010|GO:0030097|GO:0031410|GO:0010720|GO:0070507|GO:0035091|GO:0043303|GO:0032386|GO:0001883|GO:0033003|GO:0031346|GO:0000904|GO:0008017|GO:0016023|GO:0006887|GO:0036211|GO:0046907|GO:0032549|GO:0045576|GO:0017157|GO:0051046|GO:0050769|GO:0031988|GO:0022604|GO:0006461|GO:0016301|GO:0030036|GO:0006796|GO:0032273|GO:0033043|GO:0044267|GO:0032990|GO:0045639|GO:0007399|GO:0046903|GO:0034987|GO:0097485|GO:0017076|GO:0030154|GO:0032418|GO:0048858|GO:0000226|GO:0016773|GO:0005856|GO:0051960|GO:0045637|GO:0005925|GO:0010638|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0045055|GO:0043304|GO:0031532|GO:0034622|GO:0031113|GO:2000249|GO:0005524|GO:0043623|GO:0030554|GO:0016310|GO:0031116|GO:0061564|GO:0031110|GO:0051493|GO:0007167|GO:0015630|GO:0002448|GO:1903305|GO:0031109|GO:0051297|GO:0001578|GO:0004672|GO:0030099|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0051495|GO:0048812|GO:0010976|GO:0045666|GO:0051258|GO:0007409|GO:0006468|GO:0048699|GO:0004713|GO:2000251|GO:0018193|GO:0046785|GO:0045664|GO:0007169|GO:0004715|GO:0046777|GO:0018108|GO:0038083 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|extrinsic component of membrane|organic cyclic compound binding|cell-substrate junction|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|endomembrane system|transferase activity|anatomical structure development|regulation of cellular localization|regulation of cell proliferation|regulation of hemopoiesis|cytoplasmic side of plasma membrane|regulation of cell shape|chemotaxis|innate immune response|regulation of cell differentiation|organelle localization|cell development|transport|positive regulation of cellular component organization|multicellular organism development|regulation of vesicle-mediated transport|animal organ development|receptor binding|anion binding|cell-substrate adherens junction|secretion by cell|defense response|regulation of cell adhesion|adherens junction|phospholipid binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|regulation of cellular component organization|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|regulation of actin filament-based process|regulation of microtubule-based process|movement of cell or subcellular component|protein complex binding|extrinsic component of cytoplasmic side of plasma membrane|establishment of organelle localization|cell activation|cytoplasmic side of membrane|cell activation involved in immune response|extrinsic component of plasma membrane|regulation of immune response|regulation of cell activation|cell communication|regulation of cellular component movement|signal transduction|leukocyte activation involved in immune response|establishment of localization in cell|cytoskeletal protein binding|nucleotide binding|cell projection organization|leukocyte degranulation|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|microtubule-based process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|Golgi apparatus|leukocyte mediated immunity|organelle organization|vesicle-mediated transport|microtubule organizing center organization|tubulin binding|cell morphogenesis|cytosol|neuron projection development|regulation of cell projection organization|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|purine ribonucleoside triphosphate binding|macromolecule modification|cytoskeleton organization|hemopoiesis|cytoplasmic vesicle|positive regulation of cell development|regulation of microtubule cytoskeleton organization|phosphatidylinositol binding|mast cell degranulation|regulation of intracellular transport|purine nucleoside binding|regulation of mast cell activation|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|microtubule binding|cytoplasmic, membrane-bounded vesicle|exocytosis|protein modification process|intracellular transport|ribonucleoside binding|mast cell activation|regulation of exocytosis|regulation of secretion|positive regulation of neurogenesis|membrane-bounded vesicle|regulation of cell morphogenesis|protein complex assembly|kinase activity|actin cytoskeleton organization|phosphate-containing compound metabolic process|positive regulation of protein polymerization|regulation of organelle organization|cellular protein metabolic process|cell part morphogenesis|positive regulation of myeloid cell differentiation|nervous system development|secretion|immunoglobulin receptor binding|neuron projection guidance|purine nucleotide binding|cell differentiation|lysosome localization|cell projection morphogenesis|microtubule cytoskeleton organization|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|regulation of nervous system development|regulation of myeloid cell differentiation|focal adhesion|positive regulation of organelle organization|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|regulated exocytosis|regulation of mast cell degranulation|actin cytoskeleton reorganization|cellular macromolecular complex assembly|regulation of microtubule polymerization|regulation of actin cytoskeleton reorganization|ATP binding|cellular protein complex assembly|adenyl nucleotide binding|phosphorylation|positive regulation of microtubule polymerization|axon development|regulation of microtubule polymerization or depolymerization|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|microtubule cytoskeleton|mast cell mediated immunity|regulation of regulated secretory pathway|microtubule polymerization or depolymerization|centrosome organization|microtubule bundle formation|protein kinase activity|myeloid cell differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|positive regulation of cytoskeleton organization|neuron projection morphogenesis|positive regulation of neuron projection development|positive regulation of neuron differentiation|protein polymerization|axonogenesis|protein phosphorylation|generation of neurons|protein tyrosine kinase activity|positive regulation of actin cytoskeleton reorganization|peptidyl-amino acid modification|microtubule polymerization|regulation of neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|non-membrane spanning protein tyrosine kinase activity|protein autophosphorylation|peptidyl-tyrosine phosphorylation|peptidyl-tyrosine autophosphorylation K07527 tyrosine-protein kinase Fes/Fps[2.7.10.2] hsa04360 Axon guidance - Homo sapiens (human) 15:90883695-90895776 28 31 22 9 9 8 0.22591605149966 0.227322549231097 0.160037686275118 0.0650616646920828 0.0595798520432804 0.0604946366798388 0.204425429001958 0.0617120511384007 1.72795051626598 3.59175558690727e-05 0.000319893410774254 UP ENSG00000133134 BEX2 brain expressed X-linked 2 [Source:HGNC Symbol;Acc:HGNC:30933] GO:0005623|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0051726|GO:0007049|GO:0010941|GO:0043231|GO:0005737|GO:0008219|GO:0012501|GO:0005634|GO:0043067|GO:0042981|GO:0006915 cell|cellular process|binding|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|regulation of cell cycle|cell cycle|regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|cell death|programmed cell death|nucleus|regulation of programmed cell death|regulation of apoptotic process|apoptotic process - - - - X:103309346-103311046 9 11 14 2 3 1 0.201978171639573 0.224362546804452 0.283278149731596 0.0402162770347936 0.0552447847094302 0.0210297415538446 0.236539622725207 0.0388302677660228 2.60682830854973 3.65025101901471e-05 0.000324715714903651 UP ENSG00000119508 NR4A3 nuclear receptor subfamily 4 group A member 3 [Source:HGNC Symbol;Acc:HGNC:7982] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0007631|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0048520|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0050795|GO:0038023|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0044708|GO:0009605|GO:0004879|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0098531|GO:0008284|GO:0035726|GO:0002757|GO:0051726|GO:0042127|GO:0007049|GO:0044255|GO:0016337|GO:0006935|GO:0004887|GO:0035239|GO:0006725|GO:0003707|GO:0051640|GO:0009888|GO:0048468|GO:0030534|GO:0050867|GO:0006810|GO:0035295|GO:0021766|GO:1901360|GO:0048839|GO:0010941|GO:0006082|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0005102|GO:2000505|GO:0034641|GO:0015980|GO:0044281|GO:0032940|GO:0030155|GO:0030900|GO:0031325|GO:0046483|GO:0033554|GO:0007420|GO:0010942|GO:0001817|GO:0098609|GO:0043231|GO:0060004|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0000981|GO:0003012|GO:0001816|GO:0060322|GO:0007423|GO:0006928|GO:0009887|GO:0005667|GO:0042592|GO:0051656|GO:0002696|GO:0001775|GO:0048729|GO:0046983|GO:0048598|GO:0002263|GO:0048568|GO:0002367|GO:0050673|GO:0009890|GO:0045787|GO:0006979|GO:0048871|GO:0010828|GO:0001819|GO:2000253|GO:0060548|GO:0006139|GO:0050776|GO:0050865|GO:0007154|GO:0001704|GO:0006629|GO:0060259|GO:0007165|GO:0002366|GO:0050778|GO:0042180|GO:0051649|GO:0045785|GO:0008134|GO:0009725|GO:0008219|GO:0021543|GO:0030030|GO:0006091|GO:0043299|GO:0048869|GO:0010035|GO:0021537|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0002443|GO:0055114|GO:0016192|GO:0050679|GO:0000982|GO:0000902|GO:0031175|GO:1902882|GO:0003677|GO:0050905|GO:0010468|GO:0034645|GO:0048660|GO:1901215|GO:0010613|GO:0046872|GO:0007166|GO:0033993|GO:0007417|GO:0042542|GO:0010629|GO:0043583|GO:0051427|GO:0007498|GO:0035035|GO:0043069|GO:0009444|GO:0051252|GO:0006631|GO:0033005|GO:0043303|GO:0031100|GO:0044321|GO:0033003|GO:0034109|GO:0070997|GO:1901652|GO:0048659|GO:0021761|GO:0000904|GO:0005773|GO:0009790|GO:0090257|GO:0071417|GO:0010628|GO:0006887|GO:0071869|GO:0048661|GO:0002718|GO:0034440|GO:0007369|GO:0046907|GO:0045576|GO:0042472|GO:0002720|GO:0002429|GO:0022407|GO:0001707|GO:1900407|GO:0031981|GO:0043434|GO:0060005|GO:0071867|GO:0034599|GO:0007159|GO:0005654|GO:0048752|GO:0050678|GO:0060872|GO:0002764|GO:1901214|GO:0044342|GO:0001221|GO:0010565|GO:0019900|GO:0012501|GO:0014070|GO:0000302|GO:0010611|GO:0014896|GO:0010467|GO:0097009|GO:0032990|GO:0048562|GO:0007399|GO:0019216|GO:0046903|GO:0071310|GO:0097485|GO:0031328|GO:0045333|GO:0009059|GO:0030154|GO:0022409|GO:0009755|GO:0045923|GO:0032418|GO:0048858|GO:0001228|GO:0043068|GO:0030258|GO:0016070|GO:0008643|GO:0032870|GO:0010557|GO:0005634|GO:0042803|GO:0043067|GO:0048545|GO:1903202|GO:0048332|GO:0030522|GO:0010827|GO:0048666|GO:0030182|GO:0043401|GO:0019217|GO:0038097|GO:0007411|GO:0001223|GO:0044320|GO:0000975|GO:0045893|GO:0045444|GO:0045055|GO:1901031|GO:0043065|GO:1901653|GO:0000323|GO:0045892|GO:0043523|GO:0032774|GO:0043565|GO:2001141|GO:0035257|GO:0001077|GO:1903206|GO:0002768|GO:0034112|GO:1902679|GO:0071383|GO:0071407|GO:0046321|GO:0070486|GO:0003690|GO:0061564|GO:0042471|GO:0050885|GO:0071375|GO:0002448|GO:0036475|GO:0042981|GO:0046914|GO:0043066|GO:0019752|GO:0032762|GO:0051402|GO:0002431|GO:0043524|GO:0034614|GO:0019901|GO:0061469|GO:0022008|GO:0048667|GO:1903204|GO:0048812|GO:0071396|GO:0019395|GO:0071870|GO:0006351|GO:1903205|GO:0070301|GO:0006915|GO:0006355|GO:0061081|GO:1903039|GO:1903208|GO:0003300|GO:2000108|GO:0045944|GO:0006366|GO:1903507|GO:0008645|GO:0035258|GO:0046320|GO:0006352|GO:0006357|GO:0070487|GO:0007409|GO:0005764|GO:0048699|GO:1900625|GO:1903506|GO:0044212|GO:0032765|GO:0038093|GO:0032787|GO:0000122|GO:0071376|GO:0008270|GO:0006367|GO:0001047|GO:0000976|GO:0015758|GO:0001012|GO:0038095|GO:0035259|GO:0001159|GO:0006090|GO:0042629|GO:0001046|GO:0000977|GO:0000987|GO:0000978 locomotion|developmental process|macromolecular complex|signal transducer activity|immune system process|behavior|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|feeding behavior|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|positive regulation of behavior|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|regulation of behavior|signaling receptor activity|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|single-organism behavior|response to external stimulus|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|transcription factor activity, direct ligand regulated sequence-specific DNA binding|positive regulation of cell proliferation|common myeloid progenitor cell proliferation|immune response-activating signal transduction|regulation of cell cycle|regulation of cell proliferation|cell cycle|cellular lipid metabolic process|single organismal cell-cell adhesion|chemotaxis|thyroid hormone receptor activity|tube morphogenesis|cellular aromatic compound metabolic process|steroid hormone receptor activity|organelle localization|tissue development|cell development|adult behavior|positive regulation of cell activation|transport|tube development|hippocampus development|organic cyclic compound metabolic process|inner ear development|regulation of cell death|organic acid metabolic process|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|receptor binding|regulation of energy homeostasis|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|regulation of cell adhesion|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|brain development|positive regulation of cell death|regulation of cytokine production|cell-cell adhesion|intracellular membrane-bounded organelle|reflex|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|muscle system process|cytokine production|head development|sensory organ development|movement of cell or subcellular component|organ morphogenesis|transcription factor complex|homeostatic process|establishment of organelle localization|positive regulation of leukocyte activation|cell activation|tissue morphogenesis|protein dimerization activity|embryonic morphogenesis|cell activation involved in immune response|embryonic organ development|cytokine production involved in immune response|epithelial cell proliferation|negative regulation of biosynthetic process|positive regulation of cell cycle|response to oxidative stress|multicellular organismal homeostasis|positive regulation of glucose transport|positive regulation of cytokine production|positive regulation of feeding behavior|negative regulation of cell death|nucleobase-containing compound metabolic process|regulation of immune response|regulation of cell activation|cell communication|formation of primary germ layer|lipid metabolic process|regulation of feeding behavior|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|cellular ketone metabolic process|establishment of localization in cell|positive regulation of cell adhesion|transcription factor binding|response to hormone|cell death|pallium development|cell projection organization|generation of precursor metabolites and energy|leukocyte degranulation|cellular developmental process|response to inorganic substance|telencephalon development|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|leukocyte mediated immunity|oxidation-reduction process|vesicle-mediated transport|positive regulation of epithelial cell proliferation|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|cell morphogenesis|neuron projection development|regulation of response to oxidative stress|DNA binding|neuromuscular process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|negative regulation of neuron death|positive regulation of cardiac muscle hypertrophy|metal ion binding|cell surface receptor signaling pathway|response to lipid|central nervous system development|response to hydrogen peroxide|negative regulation of gene expression|ear development|hormone receptor binding|mesoderm development|histone acetyltransferase binding|negative regulation of programmed cell death|pyruvate oxidation|regulation of RNA metabolic process|fatty acid metabolic process|positive regulation of mast cell activation|mast cell degranulation|organ regeneration|response to leptin|regulation of mast cell activation|homotypic cell-cell adhesion|neuron death|response to peptide|smooth muscle cell proliferation|limbic system development|cell morphogenesis involved in differentiation|vacuole|embryo development|regulation of muscle system process|cellular response to organonitrogen compound|positive regulation of gene expression|exocytosis|response to catecholamine|positive regulation of smooth muscle cell proliferation|regulation of cytokine production involved in immune response|lipid oxidation|gastrulation|intracellular transport|mast cell activation|inner ear morphogenesis|positive regulation of cytokine production involved in immune response|immune response-activating cell surface receptor signaling pathway|regulation of cell-cell adhesion|mesoderm formation|regulation of cellular response to oxidative stress|nuclear lumen|response to peptide hormone|vestibular reflex|response to monoamine|cellular response to oxidative stress|leukocyte cell-cell adhesion|nucleoplasm|semicircular canal morphogenesis|regulation of epithelial cell proliferation|semicircular canal development|immune response-regulating signaling pathway|regulation of neuron death|type B pancreatic cell proliferation|transcription cofactor binding|regulation of cellular ketone metabolic process|kinase binding|programmed cell death|response to organic cyclic compound|response to reactive oxygen species|regulation of cardiac muscle hypertrophy|muscle hypertrophy|gene expression|energy homeostasis|cell part morphogenesis|embryonic organ morphogenesis|nervous system development|regulation of lipid metabolic process|secretion|cellular response to organic substance|neuron projection guidance|positive regulation of cellular biosynthetic process|cellular respiration|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|hormone-mediated signaling pathway|positive regulation of fatty acid metabolic process|lysosome localization|cell projection morphogenesis|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of programmed cell death|lipid modification|RNA metabolic process|carbohydrate transport|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|protein homodimerization activity|regulation of programmed cell death|response to steroid hormone|negative regulation of oxidative stress-induced cell death|mesoderm morphogenesis|intracellular receptor signaling pathway|regulation of glucose transport|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|regulation of fatty acid metabolic process|positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway|axon guidance|transcription coactivator binding|cellular response to leptin stimulus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|fat cell differentiation|regulated exocytosis|regulation of response to reactive oxygen species|positive regulation of apoptotic process|cellular response to peptide|lytic vacuole|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|nuclear hormone receptor binding|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of hydrogen peroxide-induced cell death|immune response-regulating cell surface receptor signaling pathway|positive regulation of homotypic cell-cell adhesion|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|positive regulation of fatty acid oxidation|leukocyte aggregation|double-stranded DNA binding|axon development|ear morphogenesis|neuromuscular process controlling balance|cellular response to peptide hormone stimulus|mast cell mediated immunity|neuron death in response to oxidative stress|regulation of apoptotic process|transition metal ion binding|negative regulation of apoptotic process|carboxylic acid metabolic process|mast cell cytokine production|neuron apoptotic process|Fc receptor mediated stimulatory signaling pathway|negative regulation of neuron apoptotic process|cellular response to reactive oxygen species|protein kinase binding|regulation of type B pancreatic cell proliferation|neurogenesis|cell morphogenesis involved in neuron differentiation|negative regulation of oxidative stress-induced neuron death|neuron projection morphogenesis|cellular response to lipid|fatty acid oxidation|cellular response to catecholamine stimulus|transcription, DNA-templated|regulation of hydrogen peroxide-induced cell death|cellular response to hydrogen peroxide|apoptotic process|regulation of transcription, DNA-templated|positive regulation of myeloid leukocyte cytokine production involved in immune response|positive regulation of leukocyte cell-cell adhesion|negative regulation of hydrogen peroxide-induced neuron death|cardiac muscle hypertrophy|positive regulation of leukocyte apoptotic process|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|hexose transport|steroid hormone receptor binding|regulation of fatty acid oxidation|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|monocyte aggregation|axonogenesis|lysosome|generation of neurons|positive regulation of monocyte aggregation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|positive regulation of mast cell cytokine production|Fc receptor signaling pathway|monocarboxylic acid metabolic process|negative regulation of transcription from RNA polymerase II promoter|cellular response to corticotropin-releasing hormone stimulus|zinc ion binding|transcription initiation from RNA polymerase II promoter|core promoter binding|transcription regulatory region sequence-specific DNA binding|glucose transport|RNA polymerase II regulatory region DNA binding|Fc-epsilon receptor signaling pathway|glucocorticoid receptor binding|core promoter proximal region DNA binding|pyruvate metabolic process|mast cell granule|core promoter sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K08559 nuclear receptor subfamily 4 group A member 3[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 9:99821855-99866891 8 11 28 1 5 1 0.0708132278294732 0.0884984041456181 0.223466237961987 0.00792751764495208 0.0363158422254906 0.00829505010358129 0.127592623312359 0.0175128033246747 2.8650629792993 3.69013875941191e-05 0.000327873221796081 UP ENSG00000120217 CD274 CD274 molecule [Source:HGNC Symbol;Acc:HGNC:17635] GO:0040011|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0002683|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0051050|GO:0006955|GO:0009986|GO:0051641|GO:0048870|GO:0040017|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0002684|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0060341|GO:0008284|GO:0001818|GO:0051272|GO:0042127|GO:0016337|GO:0009897|GO:0070661|GO:0050867|GO:0006810|GO:0070489|GO:0032940|GO:0030155|GO:0031982|GO:2000147|GO:0001817|GO:0098609|GO:0001816|GO:0032880|GO:0051222|GO:0006928|GO:0002696|GO:0001775|GO:0045184|GO:0001819|GO:0007162|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0070062|GO:0045785|GO:0002695|GO:0008285|GO:0051047|GO:0031295|GO:0016021|GO:2000145|GO:0010033|GO:0051249|GO:1901998|GO:0032943|GO:0007166|GO:0034097|GO:0032613|GO:1903556|GO:0034109|GO:0051223|GO:0015031|GO:0030334|GO:0070201|GO:0050714|GO:0051251|GO:0051250|GO:0050715|GO:0022408|GO:0022407|GO:0051046|GO:0032733|GO:0007159|GO:0009306|GO:0070664|GO:0050663|GO:0032689|GO:0042110|GO:0032609|GO:0032693|GO:0046903|GO:0046651|GO:0022409|GO:0030335|GO:0050707|GO:0032649|GO:1903038|GO:0042098|GO:0050863|GO:2001181|GO:0050868|GO:0050708|GO:0034112|GO:0070486|GO:2001179|GO:0034111|GO:0032945|GO:0050870|GO:0050671|GO:0050672|GO:1903039|GO:0032946|GO:0072608|GO:0050798|GO:0042130|GO:0042129|GO:0071593|GO:0042102|GO:0046006|GO:0046007 locomotion|immune system process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of immune system process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|positive regulation of transport|immune response|cell surface|cellular localization|cell motility|positive regulation of locomotion|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|positive regulation of immune system process|regulation of immune system process|protein binding|plasma membrane|endomembrane system|regulation of cellular localization|positive regulation of cell proliferation|negative regulation of cytokine production|positive regulation of cellular component movement|regulation of cell proliferation|single organismal cell-cell adhesion|external side of plasma membrane|leukocyte proliferation|positive regulation of cell activation|transport|T cell aggregation|secretion by cell|regulation of cell adhesion|vesicle|positive regulation of cell motility|regulation of cytokine production|cell-cell adhesion|cytokine production|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|positive regulation of leukocyte activation|cell activation|establishment of protein localization|positive regulation of cytokine production|negative regulation of cell adhesion|protein localization|lymphocyte activation|regulation of cell activation|cell communication|regulation of cellular component movement|cell migration|signal transduction|extracellular exosome|positive regulation of cell adhesion|negative regulation of leukocyte activation|negative regulation of cell proliferation|positive regulation of secretion|T cell costimulation|integral component of membrane|regulation of cell motility|response to organic substance|regulation of lymphocyte activation|toxin transport|mononuclear cell proliferation|cell surface receptor signaling pathway|response to cytokine|interleukin-10 production|negative regulation of tumor necrosis factor superfamily cytokine production|homotypic cell-cell adhesion|regulation of protein transport|protein transport|regulation of cell migration|regulation of establishment of protein localization|positive regulation of protein secretion|positive regulation of lymphocyte activation|negative regulation of lymphocyte activation|positive regulation of cytokine secretion|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of secretion|positive regulation of interleukin-10 production|leukocyte cell-cell adhesion|protein secretion|negative regulation of leukocyte proliferation|cytokine secretion|negative regulation of interferon-gamma production|T cell activation|interferon-gamma production|negative regulation of interleukin-10 production|secretion|lymphocyte proliferation|positive regulation of cell-cell adhesion|positive regulation of cell migration|regulation of cytokine secretion|regulation of interferon-gamma production|negative regulation of leukocyte cell-cell adhesion|T cell proliferation|regulation of T cell activation|positive regulation of interleukin-10 secretion|negative regulation of T cell activation|regulation of protein secretion|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|regulation of interleukin-10 secretion|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|positive regulation of T cell activation|positive regulation of lymphocyte proliferation|negative regulation of lymphocyte proliferation|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|interleukin-10 secretion|activated T cell proliferation|negative regulation of T cell proliferation|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of T cell proliferation|regulation of activated T cell proliferation|negative regulation of activated T cell proliferation K06745 programmed cell death 1 ligand 1[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 9:5450503-5470566 85 101 127 41 66 35 0.769865688202826 0.831376176010741 1.03707797494808 0.332716873183375 0.490466789090542 0.297091313088571 0.879439946387216 0.373424991787496 1.23576658050063 3.70259885976052e-05 0.000328882434868463 UP ENSG00000188807 TMEM201 transmembrane protein 201 [Source:HGNC Symbol;Acc:HGNC:33719] GO:0040011|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0044877|GO:0043229|GO:0051641|GO:0048870|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0051640|GO:0019866|GO:0043231|GO:0005521|GO:0005635|GO:0006928|GO:0032403|GO:0051656|GO:0016477|GO:0051649|GO:0008092|GO:0031965|GO:0016021|GO:0003779|GO:0001667|GO:0005637|GO:0051647|GO:0051015|GO:0005634|GO:0040023|GO:0007097|GO:0010761 locomotion|cell|membrane|cellular process|binding|macromolecular complex binding|intracellular organelle|cellular localization|cell motility|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|organelle localization|organelle inner membrane|intracellular membrane-bounded organelle|lamin binding|nuclear envelope|movement of cell or subcellular component|protein complex binding|establishment of organelle localization|cell migration|establishment of localization in cell|cytoskeletal protein binding|nuclear membrane|integral component of membrane|actin binding|ameboidal-type cell migration|nuclear inner membrane|nucleus localization|actin filament binding|nucleus|establishment of nucleus localization|nuclear migration|fibroblast migration - - - - 1:9588922-9614873 534 589 503 310 366 188 3.91678884901912 3.92630146715365 3.32637140190016 2.03726909228518 2.20260868132948 1.29233424922437 3.72315390602431 1.84407067427968 1.01363130656003 3.71467996918659e-05 0.000329857393813494 UP ENSG00000137338 PGBD1 piggyBac transposable element derived 1 [Source:HGNC Symbol;Acc:HGNC:19398] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0004872|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0038024|GO:0016192|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0005044|GO:0032774|GO:0043565|GO:2001141|GO:0006897|GO:0006351|GO:0006355|GO:1903506|GO:0006898 cell|membrane|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|receptor activity|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|cargo receptor activity|vesicle-mediated transport|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|scavenger receptor activity|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|endocytosis|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|receptor-mediated endocytosis - - - - 6:28281572-28302549 152 142 133 83 68 47 3.46839730829428 2.94477319200899 2.73620880526607 1.69691950672167 1.27310127632803 1.00511391395328 3.04979310185645 1.32504489900099 1.20267012741148 3.72010953623962e-05 0.000330196451271494 UP ENSG00000151304 SRFBP1 serum response factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:26333] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0030529|GO:0006139|GO:0044249|GO:0022613|GO:0031323|GO:0010468|GO:0034645|GO:0003723|GO:0030684|GO:0051252|GO:0042254|GO:0048471|GO:0042274|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006364|GO:0030686|GO:0030490|GO:0006396|GO:0032774|GO:0034660|GO:2001141|GO:0044822|GO:0006351|GO:0006355|GO:1903506|GO:0016072 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|preribosome|regulation of RNA metabolic process|ribosome biogenesis|perinuclear region of cytoplasm|ribosomal small subunit biogenesis|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|rRNA processing|90S preribosome|maturation of SSU-rRNA|RNA processing|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|rRNA metabolic process - - - - 5:121961961-122075570 86 87 144 258 285 212 1.79768069070266 1.65278537397663 2.71388076067133 4.83205759712026 4.88796422447448 4.15317403629914 2.05478227511687 4.62439861929796 -1.17028022837488 3.75687451073407e-05 0.000333108796089857 DOWN ENSG00000178385 PLEKHM3 pleckstrin homology domain containing M3 [Source:HGNC Symbol;Acc:HGNC:34006] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043167|GO:0005622|GO:0043169|GO:0007154|GO:0007165|GO:0046872|GO:0035556 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|ion binding|intracellular|cation binding|cell communication|signal transduction|metal ion binding|intracellular signal transduction - - - - 2:207828303-208025560 19 42 64 114 111 174 0.241460802459501 0.485100015688271 0.733320487079085 1.29808852395454 1.15742515938094 2.072439911513 0.486627101742286 1.50931786494949 -1.6330080962327 3.7588429560322e-05 0.000333184375324778 DOWN ENSG00000235411 AC007041.2 - - - - - - - 2:20239892-20241046 15 12 9 3 2 0 0.918646385018983 0.667920021600722 0.496942938349396 0.164597834384832 0.100492063913222 0 0.6945031149897 0.0883632994326847 2.97446197082552 3.80506046345228e-05 0.000336994076132925 UP ENSG00000108433 GOSR2 golgi SNAP receptor complex member 2 [Source:HGNC Symbol;Acc:HGNC:4431] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0006486|GO:0051640|GO:0006810|GO:0031982|GO:0033554|GO:0022607|GO:0051668|GO:0043231|GO:0030133|GO:0005737|GO:0012506|GO:0006903|GO:0005975|GO:0051656|GO:0005484|GO:0045184|GO:0030658|GO:0000149|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0005783|GO:0051649|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0005794|GO:0006996|GO:0061025|GO:0016192|GO:0051650|GO:0012507|GO:0034645|GO:0006900|GO:0016050|GO:0030968|GO:0043412|GO:0005793|GO:0006487|GO:0090114|GO:0031410|GO:0015031|GO:0033116|GO:0016023|GO:0009100|GO:0036211|GO:0046907|GO:0048199|GO:0006986|GO:0031988|GO:0070085|GO:0006461|GO:0030659|GO:1901137|GO:0044267|GO:0071310|GO:0000139|GO:0051648|GO:0009059|GO:0035967|GO:0034976|GO:0030134|GO:0034620|GO:0009101|GO:0043413|GO:0036498|GO:0048208|GO:0018279|GO:0048193|GO:0030135|GO:0006464|GO:0018193|GO:0043687|GO:0006888 transporter activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|protein glycosylation|organelle localization|transport|vesicle|cellular response to stress|cellular component assembly|localization within membrane|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|vesicle membrane|vesicle targeting|carbohydrate metabolic process|establishment of organelle localization|SNAP receptor activity|establishment of protein localization|transport vesicle membrane|SNARE binding|protein localization|cell communication|membrane organization|signal transduction|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|Golgi apparatus|organelle organization|membrane fusion|vesicle-mediated transport|establishment of vesicle localization|ER to Golgi transport vesicle membrane|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|endoplasmic reticulum unfolded protein response|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation|COPII-coated vesicle budding|cytoplasmic vesicle|protein transport|endoplasmic reticulum-Golgi intermediate compartment membrane|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|protein modification process|intracellular transport|vesicle targeting, to, from or within Golgi|response to unfolded protein|membrane-bounded vesicle|glycosylation|protein complex assembly|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular protein metabolic process|cellular response to organic substance|Golgi membrane|vesicle localization|macromolecule biosynthetic process|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|ER to Golgi transport vesicle|cellular response to unfolded protein|glycoprotein biosynthetic process|macromolecule glycosylation|IRE1-mediated unfolded protein response|COPII vesicle coating|protein N-linked glycosylation via asparagine|Golgi vesicle transport|coated vesicle|cellular protein modification process|peptidyl-amino acid modification|post-translational protein modification|ER to Golgi vesicle-mediated transport K08496 golgi SNAP receptor complex member 2[-] hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) 17:46923117-46967019 147 168 144 427 349 295 1.48420364123565 1.5415739008398 1.31084391865712 3.86278823137936 2.89114305232644 2.79143062698985 1.44554048691086 3.18178730356522 -1.13822838087438 3.81284976338176e-05 0.000337570631186237 DOWN ENSG00000164742 ADCY1 adenylate cyclase 1 (brain) [Source:HGNC Symbol;Acc:HGNC:232] GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042752|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0007623|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0004016|GO:0003014|GO:0045087|GO:0006725|GO:0048468|GO:0006810|GO:1901360|GO:0007275|GO:0050877|GO:0034641|GO:0043168|GO:0015980|GO:0044281|GO:0006952|GO:0001882|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0005887|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0007267|GO:0042592|GO:0016849|GO:0048871|GO:0042493|GO:0006139|GO:0031226|GO:0043085|GO:0055086|GO:0005516|GO:0007154|GO:0055085|GO:0007165|GO:0070062|GO:0009725|GO:0007611|GO:0050790|GO:0000166|GO:0030030|GO:0006091|GO:0048869|GO:0016021|GO:0010035|GO:0044249|GO:0019538|GO:0010033|GO:0098857|GO:0031323|GO:0050878|GO:0055114|GO:0071774|GO:0032268|GO:0000902|GO:0031175|GO:0007186|GO:0008294|GO:0046872|GO:0007166|GO:0033993|GO:0035639|GO:0043412|GO:0051345|GO:0050891|GO:0019693|GO:0048878|GO:0001883|GO:1901652|GO:0000904|GO:0071417|GO:0010038|GO:0051347|GO:0036211|GO:0003091|GO:0007613|GO:0032549|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0006112|GO:0032270|GO:0014070|GO:0006796|GO:0035556|GO:0071241|GO:1901137|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0050890|GO:0017076|GO:0051246|GO:0030154|GO:0048858|GO:0045121|GO:0032870|GO:0005634|GO:0042044|GO:0048666|GO:0030182|GO:0031401|GO:0007187|GO:0008543|GO:0009259|GO:1901653|GO:0009117|GO:0005524|GO:0046390|GO:0010226|GO:0051592|GO:0071363|GO:0030554|GO:0016310|GO:0038179|GO:0071407|GO:0030104|GO:0061564|GO:0007167|GO:0071375|GO:0006163|GO:0007616|GO:0022008|GO:0048667|GO:0006464|GO:0019932|GO:0033762|GO:0048812|GO:0009165|GO:0071396|GO:0060193|GO:0043549|GO:0006833|GO:0071248|GO:0033674|GO:0048011|GO:0006164|GO:0071377|GO:0045859|GO:0045860|GO:0019935|GO:0007188|GO:0007409|GO:0010517|GO:0006468|GO:0048699|GO:0071277|GO:0042325|GO:0001932|GO:1904322|GO:0009187|GO:0001934|GO:0010518|GO:0042327|GO:0007268|GO:0007169|GO:0009190|GO:0007193|GO:0010863|GO:0046058|GO:0007189|GO:0009152|GO:0052652|GO:0032147|GO:0038127|GO:0019933|GO:0006171|GO:0007173|GO:0007202|GO:0034199 developmental process|immune system process|behavior|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|regulation of circadian rhythm|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|circadian rhythm|organic substance metabolic process|ion binding|immune response|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|adenylate cyclase activity|renal system process|innate immune response|cellular aromatic compound metabolic process|cell development|transport|organic cyclic compound metabolic process|multicellular organism development|neurological system process|cellular nitrogen compound metabolic process|anion binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|defense response|nucleoside binding|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|cell-cell signaling|homeostatic process|phosphorus-oxygen lyase activity|multicellular organismal homeostasis|response to drug|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|calmodulin binding|cell communication|transmembrane transport|signal transduction|extracellular exosome|response to hormone|learning or memory|regulation of catalytic activity|nucleotide binding|cell projection organization|generation of precursor metabolites and energy|cellular developmental process|integral component of membrane|response to inorganic substance|cellular biosynthetic process|protein metabolic process|response to organic substance|membrane microdomain|regulation of cellular metabolic process|regulation of body fluid levels|oxidation-reduction process|response to fibroblast growth factor|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|G-protein coupled receptor signaling pathway|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding|cell surface receptor signaling pathway|response to lipid|purine ribonucleoside triphosphate binding|macromolecule modification|positive regulation of hydrolase activity|multicellular organismal water homeostasis|ribose phosphate metabolic process|chemical homeostasis|purine nucleoside binding|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|response to metal ion|positive regulation of transferase activity|protein modification process|renal water homeostasis|memory|ribonucleoside binding|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|energy reserve metabolic process|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular response to inorganic substance|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|cognition|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|membrane raft|cellular response to hormone stimulus|nucleus|fluid transport|neuron development|neuron differentiation|positive regulation of protein modification process|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|fibroblast growth factor receptor signaling pathway|ribonucleotide metabolic process|cellular response to peptide|nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|response to lithium ion|response to calcium ion|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|neurotrophin signaling pathway|cellular response to organic cyclic compound|water homeostasis|axon development|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|purine nucleotide metabolic process|long-term memory|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|second-messenger-mediated signaling|response to glucagon|neuron projection morphogenesis|nucleotide biosynthetic process|cellular response to lipid|positive regulation of lipase activity|regulation of kinase activity|water transport|cellular response to metal ion|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|purine nucleotide biosynthetic process|cellular response to glucagon stimulus|regulation of protein kinase activity|positive regulation of protein kinase activity|cyclic-nucleotide-mediated signaling|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|axonogenesis|regulation of phospholipase activity|protein phosphorylation|generation of neurons|cellular response to calcium ion|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to forskolin|cyclic nucleotide metabolic process|positive regulation of protein phosphorylation|positive regulation of phospholipase activity|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|cyclic nucleotide biosynthetic process|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|positive regulation of phospholipase C activity|cAMP metabolic process|adenylate cyclase-activating G-protein coupled receptor signaling pathway|purine ribonucleotide biosynthetic process|cyclic purine nucleotide metabolic process|activation of protein kinase activity|ERBB signaling pathway|cAMP-mediated signaling|cAMP biosynthetic process|epidermal growth factor receptor signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity K08041 adenylate cyclase 1[4.6.1.1] hsa05200|hsa05166|hsa04015|hsa04024|hsa04062|hsa04020|hsa00230|hsa04022|hsa04921|hsa04261|hsa04072|hsa04611|hsa04114|hsa04270|hsa04724|hsa04725|hsa05142|hsa04723|hsa04916|hsa04915|hsa04750|hsa05146|hsa04914|hsa04972|hsa04713|hsa04211|hsa05032|hsa04912|hsa05414|hsa04970|hsa04540|hsa04727|hsa04911|hsa04925|hsa04971|hsa04976|hsa04918|hsa04720|hsa04213|hsa04923|hsa04913 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Gap junction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Bile secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Longevity regulating pathway - multiple species - Homo sapiens (human)|Regulation of lipolysis in adipocytes - Homo sapiens (human)|Ovarian steroidogenesis - Homo sapiens (human) 7:45574140-45723116 6 12 13 33 39 37 0.0289219965714182 0.0525724154933102 0.056500020565654 0.142529096272828 0.154250907241235 0.167156511242822 0.0459981442101275 0.154645504918962 -1.74931733712869 3.84856875850232e-05 0.000340430138418751 DOWN ENSG00000111961 SASH1 SAM and SH3 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:19182] GO:0040011|GO:0032502|GO:0032991|GO:0005198|GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0040012|GO:0006950|GO:0071704|GO:0032947|GO:0044237|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0051707|GO:0009607|GO:0009605|GO:0009893|GO:0050793|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0051272|GO:0008022|GO:0001568|GO:0007275|GO:0010632|GO:0031664|GO:0031325|GO:2000147|GO:0033554|GO:0019899|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0009617|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0010634|GO:0031666|GO:0050790|GO:2000145|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0090132|GO:0007166|GO:0033993|GO:0001944|GO:0043412|GO:0072358|GO:0002237|GO:0030334|GO:0001667|GO:0051347|GO:0036211|GO:0071219|GO:0045766|GO:0031098|GO:0045765|GO:0051247|GO:0019900|GO:0032270|GO:0006796|GO:1901342|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:0010594|GO:0051246|GO:0030335|GO:1902531|GO:0072359|GO:0032496|GO:0010595|GO:0070304|GO:0031401|GO:0043408|GO:0038061|GO:0016310|GO:1901222|GO:0043410|GO:0010631|GO:0032872|GO:0019901|GO:0006464|GO:0071396|GO:0051403|GO:0043549|GO:0071222|GO:1901224|GO:0033674|GO:0031663|GO:0045859|GO:0045860|GO:0043406|GO:1900744|GO:0046328|GO:0038066|GO:0006468|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0031435|GO:0032874|GO:0001934|GO:0043542|GO:0042327|GO:0032446|GO:0046330|GO:0043507|GO:1900745|GO:0031396|GO:0071902|GO:0071900|GO:0043506|GO:0016567|GO:1902498|GO:0051865|GO:1900044|GO:0000209|GO:0070534 locomotion|developmental process|macromolecular complex|structural molecule activity|signaling|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of locomotion|response to stress|organic substance metabolic process|protein complex scaffold|cellular metabolic process|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|response to other organism|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|regulation of developmental process|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|positive regulation of cellular component movement|protein C-terminus binding|blood vessel development|multicellular organism development|regulation of epithelial cell migration|regulation of lipopolysaccharide-mediated signaling pathway|positive regulation of cellular metabolic process|positive regulation of cell motility|cellular response to stress|enzyme binding|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|response to bacterium|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|positive regulation of epithelial cell migration|positive regulation of lipopolysaccharide-mediated signaling pathway|regulation of catalytic activity|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|epithelium migration|cell surface receptor signaling pathway|response to lipid|vasculature development|macromolecule modification|cardiovascular system development|response to molecule of bacterial origin|regulation of cell migration|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|cellular response to molecule of bacterial origin|positive regulation of angiogenesis|stress-activated protein kinase signaling cascade|regulation of angiogenesis|positive regulation of protein metabolic process|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of endothelial cell migration|regulation of protein metabolic process|positive regulation of cell migration|regulation of intracellular signal transduction|circulatory system development|response to lipopolysaccharide|positive regulation of endothelial cell migration|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of protein modification process|regulation of MAPK cascade|NIK/NF-kappaB signaling|phosphorylation|regulation of NIK/NF-kappaB signaling|positive regulation of MAPK cascade|epithelial cell migration|regulation of stress-activated MAPK cascade|protein kinase binding|cellular protein modification process|cellular response to lipid|stress-activated MAPK cascade|regulation of kinase activity|cellular response to lipopolysaccharide|positive regulation of NIK/NF-kappaB signaling|positive regulation of kinase activity|lipopolysaccharide-mediated signaling pathway|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of p38MAPK cascade|regulation of JNK cascade|p38MAPK cascade|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|mitogen-activated protein kinase kinase kinase binding|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|endothelial cell migration|positive regulation of phosphorylation|protein modification by small protein conjugation|positive regulation of JNK cascade|positive regulation of JUN kinase activity|positive regulation of p38MAPK cascade|regulation of protein ubiquitination|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|protein ubiquitination|regulation of protein autoubiquitination|protein autoubiquitination|regulation of protein K63-linked ubiquitination|protein polyubiquitination|protein K63-linked ubiquitination - - - - 6:148272304-148552050 153 209 505 625 747 1094 0.924703698580484 1.14799013663563 2.75180125631567 3.3844598817434 3.70424777265506 6.19665944156061 1.60816503051059 4.42845569865302 -1.46138822248793 3.85632546264712e-05 0.000340967428680186 DOWN ENSG00000175691 ZNF77 zinc finger protein 77 [Source:HGNC Symbol;Acc:HGNC:13150] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:2933218-2944971 91 100 120 53 39 55 2.52334472855863 2.52008240215874 3.00006507038197 1.31677342643833 0.887290400963497 1.42929796012423 2.68116406703311 1.21112059584202 1.1465169773176 3.85692706723719e-05 0.000340967428680186 UP ENSG00000267110 CTD-2587H24.4 - - - - - - - 19:55154757-55160671 16 18 8 0 4 3 1.16082386473799 1.18684249992128 0.523307093306367 0 0.238088889886711 0.203956139623748 0.956991152655212 0.147348343170153 2.69927474866649 3.86034093525382e-05 0.000341168200950466 UP ENSG00000119725 ZNF410 zinc finger protein 410 [Source:HGNC Symbol;Acc:HGNC:20144] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 14:73886617-73932511 2036 1966 1246 1043 1032 714 11.1203942952901 9.75901617136884 6.13584924630833 5.10416316814246 4.62476927393842 3.6548487071828 9.00508657098909 4.46126038308789 1.01328879165078 3.8799616974745e-05 0.000342800759148872 UP ENSG00000126759 CFP complement factor properdin [Source:HGNC Symbol;Acc:HGNC:8864] GO:0031012|GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0005615|GO:0002684|GO:0005622|GO:0002682|GO:0012505|GO:0019222|GO:0006486|GO:0045087|GO:0006959|GO:0006952|GO:0098542|GO:0043231|GO:0005737|GO:0009611|GO:0005975|GO:0006956|GO:0009617|GO:0050776|GO:0050778|GO:0005783|GO:0044249|GO:0019538|GO:0010468|GO:0034645|GO:0043412|GO:0050727|GO:0051604|GO:0006493|GO:0009100|GO:0036211|GO:0006954|GO:0006957|GO:0030449|GO:0006508|GO:0070085|GO:1901137|GO:0044267|GO:0010467|GO:0005788|GO:0051246|GO:0042742|GO:0009059|GO:0002920|GO:0009101|GO:0043413|GO:0002673|GO:0016485|GO:0036065|GO:0030162|GO:0002526|GO:0036066|GO:0006464|GO:0070613|GO:0043687 extracellular matrix|immune system process|cell|cellular process|extracellular region|metabolic process|response to stimulus|intracellular organelle|response to stress|organic substance metabolic process|immune response|cellular metabolic process|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|extracellular space|positive regulation of immune system process|intracellular|regulation of immune system process|endomembrane system|regulation of metabolic process|protein glycosylation|innate immune response|humoral immune response|defense response|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|response to wounding|carbohydrate metabolic process|complement activation|response to bacterium|regulation of immune response|positive regulation of immune response|endoplasmic reticulum|cellular biosynthetic process|protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|regulation of inflammatory response|protein maturation|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|inflammatory response|complement activation, alternative pathway|regulation of complement activation|proteolysis|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|gene expression|endoplasmic reticulum lumen|regulation of protein metabolic process|defense response to bacterium|macromolecule biosynthetic process|regulation of humoral immune response|glycoprotein biosynthetic process|macromolecule glycosylation|regulation of acute inflammatory response|protein processing|fucosylation|regulation of proteolysis|acute inflammatory response|protein O-linked fucosylation|cellular protein modification process|regulation of protein processing|post-translational protein modification K15412 complement factor properdin[-] hsa05168 Herpes simplex infection - Homo sapiens (human) X:47624213-47630305 23 18 14 4 4 5 0.247862787817054 0.176290590710428 0.13602875197349 0.0386233105465172 0.0353651230407592 0.0505026270016746 0.186727376833657 0.041497020196317 2.16985381350955 3.88292732673467e-05 0.000342883185849767 UP ENSG00000140961 OSGIN1 oxidative stress induced growth inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:30093] GO:0032502|GO:0040007|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0048523|GO:0016491|GO:0050794|GO:0016049|GO:0045926|GO:0016043|GO:0040008|GO:0005515|GO:0048856|GO:0010941|GO:0007275|GO:0005102|GO:0051128|GO:0010942|GO:0030308|GO:0008219|GO:0048869|GO:0001558|GO:0055114|GO:0012501|GO:0030154|GO:0043068|GO:0008083|GO:0043067|GO:0043065|GO:0042981|GO:0006915 developmental process|growth|cellular process|metabolic process|binding|catalytic activity|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|cell growth|negative regulation of growth|cellular component organization|regulation of growth|protein binding|anatomical structure development|regulation of cell death|multicellular organism development|receptor binding|regulation of cellular component organization|positive regulation of cell death|negative regulation of cell growth|cell death|cellular developmental process|regulation of cell growth|oxidation-reduction process|programmed cell death|cell differentiation|positive regulation of programmed cell death|growth factor activity|regulation of programmed cell death|positive regulation of apoptotic process|regulation of apoptotic process|apoptotic process - - - - 16:83948282-83966332 481 529 330 250 252 188 6.17054786187278 6.16757584774857 3.81687036127776 2.87354011715856 2.65244797319969 2.2602958831193 5.38499802363304 2.59542799115918 1.05297335384243 3.88319170415375e-05 0.000342883185849767 UP ENSG00000134313 KIDINS220 kinase D-interacting substrate 220kDa [Source:HGNC Symbol;Acc:HGNC:29508] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0031224|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0019222|GO:0045595|GO:0048468|GO:0006810|GO:0051130|GO:0007275|GO:0016358|GO:0031325|GO:0051128|GO:0045597|GO:0043231|GO:0005737|GO:1990089|GO:0009966|GO:0019904|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0051649|GO:0050790|GO:0030030|GO:0019207|GO:0048869|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0005768|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0031344|GO:0007166|GO:0043412|GO:1990090|GO:0010720|GO:0019887|GO:0048813|GO:0030165|GO:0031346|GO:0000904|GO:0009790|GO:0051347|GO:0036211|GO:0046907|GO:0005770|GO:0050769|GO:0051247|GO:0070848|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0009792|GO:0038180|GO:0031401|GO:0043408|GO:0071363|GO:0016310|GO:0038179|GO:0016482|GO:0007167|GO:0043410|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0010976|GO:0043549|GO:0033674|GO:0045666|GO:0048011|GO:0000186|GO:0045859|GO:0045860|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0043009|GO:0001934|GO:0045664|GO:0042327|GO:0007169|GO:0071900|GO:0001701|GO:0032147 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|intrinsic component of membrane|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cell development|transport|positive regulation of cellular component organization|multicellular organism development|dendrite development|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|response to nerve growth factor|regulation of signal transduction|protein domain specific binding|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|establishment of localization in cell|regulation of catalytic activity|cell projection organization|kinase regulator activity|cellular developmental process|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|endosome|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|regulation of cell projection organization|cell surface receptor signaling pathway|macromolecule modification|cellular response to nerve growth factor stimulus|positive regulation of cell development|protein kinase regulator activity|dendrite morphogenesis|PDZ domain binding|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|embryo development|positive regulation of transferase activity|protein modification process|intracellular transport|late endosome|positive regulation of neurogenesis|positive regulation of protein metabolic process|response to growth factor|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|embryo development ending in birth or egg hatching|nerve growth factor signaling pathway|positive regulation of protein modification process|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|neurotrophin signaling pathway|cytosolic transport|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|regulation of kinase activity|positive regulation of kinase activity|positive regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|chordate embryonic development|positive regulation of protein phosphorylation|regulation of neuron differentiation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of protein serine/threonine kinase activity|in utero embryonic development|activation of protein kinase activity K12460 ankyrin repeat-rich membrane spanning protein[-] hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) 2:8725278-8837630 133 189 238 335 420 692 0.528865847898914 0.683024932126708 0.853267518415616 1.19353804395138 1.37028701002142 2.57886998566046 0.688386099480413 1.71423167987775 -1.31627223352471 3.90056256426527e-05 0.000344315182713115 DOWN ENSG00000232756 RP5-1185I7.1 - - - - - - - 7:77990384-77995171 18 26 29 61 83 63 0.41246206479296 0.541454439279497 0.599135125924141 1.25237178927334 1.56046502136043 1.35293021575933 0.517683876665533 1.3885890087977 -1.42347636604588 3.92230891128506e-05 0.000345927947525862 DOWN ENSG00000175606 TMEM70 transmembrane protein 70 [Source:HGNC Symbol;Acc:HGNC:26050] GO:0005623|GO:0016020|GO:0009987|GO:0043229|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0022607|GO:0043231|GO:0005737|GO:0031966|GO:0016021|GO:0031301|GO:0006996|GO:0005740|GO:0007005|GO:0005743|GO:0031981|GO:0005654|GO:0005739|GO:0006461|GO:0032592|GO:0005634|GO:0043461|GO:0034622|GO:0043623|GO:0033615 cell|membrane|cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|integral component of membrane|integral component of organelle membrane|organelle organization|mitochondrial envelope|mitochondrion organization|mitochondrial inner membrane|nuclear lumen|nucleoplasm|mitochondrion|protein complex assembly|integral component of mitochondrial membrane|nucleus|proton-transporting ATP synthase complex assembly|cellular macromolecular complex assembly|cellular protein complex assembly|mitochondrial proton-transporting ATP synthase complex assembly - - - - 8:73972437-73982783 1025 1004 452 416 425 281 13.3306211067822 11.8669814555436 5.30004509480114 4.84749715563056 4.53506812217227 3.42500855008311 10.1658825523756 4.26919127596198 1.2517007610154 3.947128221647e-05 0.00034780863615422 UP ENSG00000099219 ERMP1 endoplasmic reticulum metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:23703] GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0005783|GO:0016021|GO:0019538|GO:0046872|GO:0006508|GO:0008237 cell|membrane|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|endoplasmic reticulum|integral component of membrane|protein metabolic process|metal ion binding|proteolysis|metallopeptidase activity - - - - 9:5765076-5833117 551 636 829 1195 1238 1972 3.20790249880935 3.36516748737481 4.35149273777974 6.23354618895405 5.91368221803276 10.7598288302637 3.64152090798797 7.63568574575017 -1.06821659992973 3.94992664704793e-05 0.000347952523225048 DOWN ENSG00000119636 BBOF1 basal body orientation factor 1 [Source:HGNC Symbol;Acc:HGNC:19855] GO:0032502|GO:0005623|GO:0009987|GO:0042995|GO:0043229|GO:0009653|GO:0016043|GO:0005622|GO:0048856|GO:0005929|GO:0048646|GO:0022607|GO:0005737|GO:0036064|GO:0030030|GO:0048869|GO:0006996|GO:0000902|GO:0005815|GO:0044782|GO:0030031|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0005856|GO:0060271|GO:0015630|GO:0044458 developmental process|cell|cellular process|cell projection|intracellular organelle|anatomical structure morphogenesis|cellular component organization|intracellular|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|cellular component assembly|cytoplasm|ciliary basal body|cell projection organization|cellular developmental process|organelle organization|cell morphogenesis|microtubule organizing center|cilium organization|cell projection assembly|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|cytoskeleton|cilium morphogenesis|microtubule cytoskeleton|motile cilium assembly - - - - 14:74019353-74082863 119 147 162 328 328 276 1.47367969643743 1.65445795348058 1.80878456408485 3.63939326938188 3.33272821034104 3.20329005199815 1.64564073800095 3.39180384390702 -1.04340332434653 3.99013132232472e-05 0.000351390502940065 DOWN ENSG00000239002 SCARNA10 small Cajal body-specific RNA 10 [Source:HGNC Symbol;Acc:HGNC:32567] - - - - - - 12:6510222-6510551 7 14 6 1 1 0 1.5005093063988 2.72734008820295 1.15960094539479 0.191966040911552 0.175949174498038 0 1.79581677999885 0.12263840513653 3.87215741951311 4.02544494057199e-05 0.000354082596511008 UP ENSG00000029639 TFB1M transcription factor B1, mitochondrial [Source:HGNC Symbol;Acc:HGNC:17037] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0042645|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0022613|GO:0031323|GO:0006996|GO:0003677|GO:0008168|GO:0010468|GO:0034645|GO:0003723|GO:0043412|GO:0007005|GO:0051252|GO:0042254|GO:0001510|GO:0005759|GO:0005739|GO:0010467|GO:0009059|GO:0016070|GO:0006364|GO:0006396|GO:0032774|GO:0034660|GO:2001141|GO:0031167|GO:0009451|GO:0044822|GO:0008173|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0000179|GO:0008649|GO:1903506|GO:0016072|GO:0000154|GO:0016433 cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|mitochondrial nucleoid|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|regulation of cellular metabolic process|organelle organization|DNA binding|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|RNA binding|macromolecule modification|mitochondrion organization|regulation of RNA metabolic process|ribosome biogenesis|RNA methylation|mitochondrial matrix|mitochondrion|gene expression|macromolecule biosynthetic process|RNA metabolic process|rRNA processing|RNA processing|RNA biosynthetic process|ncRNA metabolic process|regulation of RNA biosynthetic process|rRNA methylation|RNA modification|poly(A) RNA binding|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|rRNA (adenine-N6,N6-)-dimethyltransferase activity|rRNA methyltransferase activity|regulation of nucleic acid-templated transcription|rRNA metabolic process|rRNA modification|rRNA (adenine) methyltransferase activity - - - - 6:155257509-155314493 66 73 91 153 218 174 1.01757060536739 1.02288654673713 1.26495986504285 2.11353918890136 2.75769838853294 2.51421110450771 1.10180567238246 2.461816227314 -1.15985327436339 4.06388341707314e-05 0.000357253167059192 DOWN ENSG00000168778 TCTN2 tectonic family member 2 [Source:HGNC Symbol;Acc:HGNC:25774] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0031090|GO:0060170|GO:0022607|GO:0005737|GO:0072372|GO:0036038|GO:0007154|GO:0007165|GO:0035869|GO:0030030|GO:0031253|GO:0048869|GO:0016021|GO:0006996|GO:0000902|GO:0007166|GO:0044782|GO:0030031|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0005856|GO:0031513|GO:0060271|GO:0007224 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|organelle membrane|ciliary membrane|cellular component assembly|cytoplasm|primary cilium|TCTN-B9D complex|cell communication|signal transduction|ciliary transition zone|cell projection organization|cell projection membrane|cellular developmental process|integral component of membrane|organelle organization|cell morphogenesis|cell surface receptor signaling pathway|cilium organization|cell projection assembly|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|cytoskeleton|nonmotile primary cilium|cilium morphogenesis|smoothened signaling pathway - - - - 12:123671113-123708403 98 104 160 277 273 268 1.08180719002258 1.04336445321836 1.59241905837378 2.73968274798358 2.4725971927831 2.77260241842093 1.23919690053824 2.66162745306254 -1.10290321113269 4.0682556987626e-05 0.000357532250900379 DOWN ENSG00000228915 OR7E128P olfactory receptor family 7 subfamily E member 128 pseudogene [Source:HGNC Symbol;Acc:HGNC:15305] - - - - - - 11:71893410-71894433 1 0 1 5 11 12 0.0691080990455213 0 0.0622506619334419 0.309445511648585 0.623442281917198 0.776854942659198 0.0437862536596544 0.569914245408327 -3.70219493073449 4.14394738285764e-05 0.000363862956375977 DOWN ENSG00000176473 WDR25 WD repeat domain 25 [Source:HGNC Symbol;Acc:HGNC:21064] GO:0005488|GO:0005515 binding|protein binding - - - - 14:100376418-100530303 9 9 18 40 46 36 0.100590171750345 0.091422996266313 0.181388044863461 0.400564067950915 0.42182746751486 0.377084673818843 0.12446707096004 0.399825403094873 -1.68360602429591 4.15022554300172e-05 0.000364199980484343 DOWN ENSG00000188917 TRMT2B tRNA methyltransferase 2 homolog B [Source:HGNC Symbol;Acc:HGNC:25748] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0008168|GO:0043412|GO:0001510|GO:0005739|GO:0010467|GO:0016070|GO:0006396|GO:0034660|GO:0009451|GO:0008173|GO:0008757|GO:0030697|GO:0006399|GO:0008175|GO:0008033|GO:0016300 cell|cellular process|metabolic process|binding|catalytic activity|methylation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|methyltransferase activity|macromolecule modification|RNA methylation|mitochondrion|gene expression|RNA metabolic process|RNA processing|ncRNA metabolic process|RNA modification|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity|tRNA metabolic process|tRNA methyltransferase activity|tRNA processing|tRNA (uracil) methyltransferase activity - - - - X:101009346-101052116 196 270 200 537 563 403 1.70849549566597 2.13894905253836 1.57181474523401 4.19401057069124 4.02655251290199 3.2922415516007 1.80641976447945 3.83760154506464 -1.08707174931018 4.24115584283124e-05 0.000371316081638572 DOWN ENSG00000261371 PECAM1 platelet/endothelial cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:8823] GO:0040011|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0040012|GO:0043229|GO:0006950|GO:0071704|GO:0009986|GO:0044237|GO:0048870|GO:0023051|GO:0071944|GO:0009893|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0009897|GO:0031325|GO:0005737|GO:0009611|GO:0006928|GO:0009966|GO:0010646|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0030485|GO:0016021|GO:2000145|GO:0009967|GO:0019538|GO:0098857|GO:0031323|GO:1902533|GO:0032268|GO:0043412|GO:0030334|GO:0036211|GO:0042060|GO:0043292|GO:0051247|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:0045121|GO:1902531|GO:0031401|GO:0016310|GO:0007264|GO:0006464|GO:0007259|GO:0007265|GO:0006468|GO:0046425|GO:0042325|GO:0001932|GO:0018193|GO:0046427|GO:0001934|GO:0042327|GO:0050731|GO:0050730|GO:0007260|GO:0042531|GO:0007266|GO:0018108|GO:0042506|GO:0042523 locomotion|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of locomotion|intracellular organelle|response to stress|organic substance metabolic process|cell surface|cellular metabolic process|cell motility|regulation of signaling|cell periphery|positive regulation of metabolic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|regulation of metabolic process|external side of plasma membrane|positive regulation of cellular metabolic process|cytoplasm|response to wounding|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|cell communication|regulation of cellular component movement|cell migration|signal transduction|smooth muscle contractile fiber|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|membrane microdomain|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|macromolecule modification|regulation of cell migration|protein modification process|wound healing|contractile fiber|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|membrane raft|regulation of intracellular signal transduction|positive regulation of protein modification process|phosphorylation|small GTPase mediated signal transduction|cellular protein modification process|JAK-STAT cascade|Ras protein signal transduction|protein phosphorylation|regulation of JAK-STAT cascade|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of JAK-STAT cascade|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|tyrosine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|Rho protein signal transduction|peptidyl-tyrosine phosphorylation|tyrosine phosphorylation of Stat5 protein|positive regulation of tyrosine phosphorylation of Stat5 protein K06471 platelet/endothelial cell adhesion molecule[-] hsa04514|hsa04670|hsa05144 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|Malaria - Homo sapiens (human) 17:64319415-64413776 27 33 54 84 100 204 0.211085940652498 0.23447296565729 0.380630864220689 0.588395144157602 0.641448225069752 1.49469324260214 0.275396590176826 0.908178870609831 -1.72146577503227 4.24126696049954e-05 0.000371316081638572 DOWN ENSG00000233225 AC004987.9 - - - - - - - 7:39833571-39834718 21 15 28 58 76 57 1.2939932171906 0.840017383139296 1.555504100657 3.20205680729296 3.84223631698257 3.29162117054246 1.2298382336623 3.44530476493933 -1.48616304290256 4.25654780640855e-05 0.00037243545783271 DOWN ENSG00000251348 HSPD1P11 heat shock protein family D (Hsp60) member 1 pseudogene 11 [Source:HGNC Symbol;Acc:HGNC:35142] - - - - - - 5:95768999-95770700 0 3 3 11 11 27 0 0.113332744356685 0.112397639138232 0.409610646045334 0.375091008627033 1.05166079638637 0.0752434611649723 0.612120817019579 -3.0241783133712 4.29813798732166e-05 0.000375524177563655 DOWN ENSG00000138944 KIAA1644 KIAA1644 [Source:HGNC Symbol;Acc:HGNC:29335] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 22:44243667-44312851 9 9 17 40 54 31 0.0943023547634327 0.085708212615834 0.160597468488707 0.375525105326817 0.464239001411579 0.304420111644329 0.113536011955991 0.381394739460908 -1.74813497305273 4.30771607819996e-05 0.000376140847612113 DOWN ENSG00000268945 CTD-2192J16.26 - - - - - - - 19:12682693-12687279 17 20 14 4 2 6 1.89370661510749 2.0247969158762 1.4061302802425 0.399249465239904 0.182784777668932 0.626433053569623 1.7748779370754 0.402822432159486 2.13950387945536 4.30672133150677e-05 0.000376140847612113 UP ENSG00000169359 SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 [Source:HGNC Symbol;Acc:HGNC:95] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0022857|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0046483|GO:0005887|GO:0043231|GO:0005737|GO:0022891|GO:0006139|GO:0031226|GO:0007154|GO:0055085|GO:0007165|GO:0005783|GO:0016021|GO:0044249|GO:0010033|GO:0031323|GO:0005794|GO:0008521|GO:0010468|GO:0071773|GO:0034645|GO:0007166|GO:0051252|GO:0051181|GO:0006811|GO:0015075|GO:0070848|GO:0010467|GO:0071310|GO:0060395|GO:0000139|GO:0009059|GO:0016070|GO:0006820|GO:0015711|GO:0015293|GO:0015992|GO:0032774|GO:0006812|GO:2001141|GO:0071363|GO:0030509|GO:0007167|GO:0006351|GO:0006355|GO:0008324|GO:0015876|GO:0006366|GO:0006357|GO:1903506|GO:0007178|GO:0015672|GO:0015295 transporter activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|transmembrane transporter activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|cell communication|transmembrane transport|signal transduction|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|acetyl-CoA transporter activity|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|regulation of RNA metabolic process|cofactor transport|ion transport|ion transmembrane transporter activity|response to growth factor|gene expression|cellular response to organic substance|SMAD protein signal transduction|Golgi membrane|macromolecule biosynthetic process|RNA metabolic process|anion transport|organic anion transport|symporter activity|proton transport|RNA biosynthetic process|cation transport|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|BMP signaling pathway|enzyme linked receptor protein signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|cation transmembrane transporter activity|acetyl-CoA transport|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway|monovalent inorganic cation transport|solute:proton symporter activity K03372 MFS transporter, PAT family, solute carrier family 33 (acetyl-CoA transportor), member 1 [EC:2.3.1.-][-] hsa01100|hsa00604 Metabolic pathways - Homo sapiens (human)|Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human) 3:155821024-155854429 324 338 530 569 1052 1243 1.82794182249066 1.7330601453761 2.69592437626891 2.87625769232462 4.8696864193909 6.57230399320567 2.08564211471189 4.77274936830706 -1.19432895787715 4.31380704082231e-05 0.00037645248581324 DOWN ENSG00000146576 C7orf26 chromosome 7 open reading frame 26 [Source:HGNC Symbol;Acc:HGNC:21702] - - - - - - 7:6590017-6608726 535 512 332 209 265 240 6.55765241594422 5.7035452285218 3.66899658223514 2.29530088831228 2.66507182049472 2.75698377398433 5.31006474223372 2.57245216093044 1.04558520296669 4.31771703425291e-05 0.000376683589539995 UP ENSG00000267327 CTD-2008L17.1 - - - - - - - 18:55893038-56023522 5 9 5 24 30 24 0.350198955658687 0.572887270662867 0.315699886937325 1.50601618252672 1.72390222771727 1.57531627655093 0.412928704419626 1.60174489559831 -1.95567977802108 4.32040116944358e-05 0.000376697594954932 DOWN ENSG00000233030 RP11-196G18.3 - - - - - - - 1:149785659-149793020 7 8 6 30 49 19 0.139759545896586 0.145159022476025 0.108006861975806 0.536652966410668 0.802675022101516 0.355509510493211 0.130975143449472 0.564945833001798 -2.10881950647134 4.33301744883908e-05 0.000377687307788736 DOWN ENSG00000121289 CEP89 centrosomal protein 89kDa [Source:HGNC Symbol;Acc:HGNC:25907] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0043229|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0022607|GO:0043231|GO:0031514|GO:0005737|GO:0005758|GO:0072372|GO:0030030|GO:0048869|GO:0097539|GO:0006996|GO:0005740|GO:0000902|GO:0005829|GO:0005813|GO:0005815|GO:0005814|GO:0044782|GO:0030031|GO:0005739|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0005856|GO:0000922|GO:0005819|GO:0031513|GO:0060271|GO:0035058|GO:0015630 developmental process|macromolecular complex|cell|membrane|cellular process|binding|cell projection|intracellular organelle|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|cellular component assembly|intracellular membrane-bounded organelle|motile cilium|cytoplasm|mitochondrial intermembrane space|primary cilium|cell projection organization|cellular developmental process|ciliary transition fiber|organelle organization|mitochondrial envelope|cell morphogenesis|cytosol|centrosome|microtubule organizing center|centriole|cilium organization|cell projection assembly|mitochondrion|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|cytoskeleton|spindle pole|spindle|nonmotile primary cilium|cilium morphogenesis|nonmotile primary cilium assembly|microtubule cytoskeleton - - - - 19:32875925-32971991 236 245 421 564 724 637 1.41138958295179 1.33162152807152 2.2700252817807 3.02211554144622 3.55255689129219 3.5702831046573 1.67101213093467 3.38165184579857 -1.0170059294578 4.34588583100614e-05 0.000378698410971563 DOWN ENSG00000256967 RP11-273B20.1 - - - - - - - 12:7129079-7131198 1 2 5 24 45 6 0.0476864510934056 0.0866405688397163 0.214863130597506 1.02498405953638 1.75993324505804 0.268049183973525 0.116396716843543 1.01765549618931 -3.12812698251002 4.40579058996299e-05 0.000383470764643601 DOWN ENSG00000136866 ZFP37 ZFP37 zinc finger protein [Source:HGNC Symbol;Acc:HGNC:12863] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0008270 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 9:113038380-113056759 117 84 70 32 33 45 0.794565216988695 0.518445984508625 0.428603124333954 0.194712285446108 0.18387795808358 0.286406598094213 0.580538108610425 0.221665613874634 1.389005786007 4.47737705543774e-05 0.00038924756730646 UP ENSG00000244733 RP11-506M13.3 - - - - - - - 10:79660891-79677996 18 10 11 37 53 47 0.693124874260135 0.349958095150079 0.38188633521338 1.27653531253937 1.67447701194622 1.69616392664952 0.474989768207865 1.54905875037837 -1.70542351985709 4.47713279629497e-05 0.00038924756730646 DOWN ENSG00000164404 GDF9 growth differentiation factor 9 [Source:HGNC Symbol;Acc:HGNC:4224] GO:0032502|GO:0040007|GO:0000003|GO:0023052|GO:0005623|GO:0048511|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0006807|GO:0016049|GO:0044702|GO:0071704|GO:0042698|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0023051|GO:0045926|GO:0016043|GO:0040008|GO:0009893|GO:0032504|GO:0009058|GO:0005615|GO:0050793|GO:0048589|GO:0005622|GO:0022602|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0060341|GO:0008284|GO:0042127|GO:0006725|GO:0048468|GO:0009994|GO:0006810|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0032940|GO:0031325|GO:0046483|GO:0051128|GO:0048608|GO:0001553|GO:0030308|GO:0005737|GO:0007267|GO:0071559|GO:2000194|GO:0009966|GO:0007548|GO:0046883|GO:0010646|GO:0006139|GO:0008406|GO:0007154|GO:0007276|GO:0007165|GO:0048588|GO:0008219|GO:0001555|GO:0010817|GO:0048869|GO:0009967|GO:0044249|GO:0010876|GO:0019538|GO:0023014|GO:0042701|GO:0010033|GO:0001558|GO:0007281|GO:0031323|GO:0000165|GO:0032268|GO:0010468|GO:0005126|GO:0071773|GO:0034645|GO:0007166|GO:0043412|GO:0008585|GO:0061458|GO:0051252|GO:0005125|GO:0048477|GO:0046545|GO:2000870|GO:0036211|GO:0071560|GO:0051046|GO:0032368|GO:0006869|GO:0009914|GO:0051247|GO:0070848|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0046903|GO:0071310|GO:0060395|GO:0051246|GO:0009059|GO:0030154|GO:0048599|GO:1902531|GO:0016070|GO:0008083|GO:0007292|GO:0043067|GO:0060393|GO:0031401|GO:0043408|GO:0032774|GO:2001141|GO:0071363|GO:0016310|GO:0007179|GO:0030509|GO:0007167|GO:0010862|GO:0042981|GO:0005160|GO:0006464|GO:0046879|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:0006357|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0001934|GO:0007178|GO:0042327|GO:0060389 developmental process|growth|reproduction|signaling|cell|rhythmic process|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|cell growth|single organism reproductive process|organic substance metabolic process|ovulation cycle|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|regulation of signaling|negative regulation of growth|cellular component organization|regulation of growth|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|extracellular space|regulation of developmental process|developmental growth|intracellular|ovulation cycle process|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|cell development|oocyte differentiation|transport|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|secretion by cell|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|reproductive structure development|luteinization|negative regulation of cell growth|cytoplasm|cell-cell signaling|response to transforming growth factor beta|regulation of female gonad development|regulation of signal transduction|sex differentiation|regulation of hormone secretion|regulation of cell communication|nucleobase-containing compound metabolic process|gonad development|cell communication|gamete generation|signal transduction|developmental cell growth|cell death|oocyte growth|regulation of hormone levels|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|protein metabolic process|signal transduction by protein phosphorylation|progesterone secretion|response to organic substance|regulation of cell growth|germ cell development|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|regulation of gene expression|cytokine receptor binding|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|macromolecule modification|female gonad development|reproductive system development|regulation of RNA metabolic process|cytokine activity|oogenesis|development of primary female sexual characteristics|regulation of progesterone secretion|protein modification process|cellular response to transforming growth factor beta stimulus|regulation of secretion|regulation of lipid transport|lipid transport|hormone transport|positive regulation of protein metabolic process|response to growth factor|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|secretion|cellular response to organic substance|SMAD protein signal transduction|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|oocyte development|regulation of intracellular signal transduction|RNA metabolic process|growth factor activity|female gamete generation|regulation of programmed cell death|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein modification process|regulation of MAPK cascade|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|phosphorylation|transforming growth factor beta receptor signaling pathway|BMP signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of apoptotic process|transforming growth factor beta receptor binding|cellular protein modification process|hormone secretion|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|positive regulation of phosphorylation|pathway-restricted SMAD protein phosphorylation K05498 growth differentiation factor 9/9B[-] hsa04913 Ovarian steroidogenesis - Homo sapiens (human) 5:132861181-132866884 38 43 18 9 12 7 0.479231220169026 0.492847996801187 0.204671944364565 0.101692924648866 0.124169749379134 0.0827368041352163 0.392250387111593 0.102866492721072 1.93100174937335 4.55422797594516e-05 0.000395698259586341 UP ENSG00000196917 HCAR1 hydroxycarboxylic acid receptor 1 [Source:HGNC Symbol;Acc:HGNC:4532] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0006950|GO:0009056|GO:0006914|GO:0038023|GO:0016043|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0002682|GO:0005886|GO:0050688|GO:0006952|GO:0033554|GO:0098542|GO:0004888|GO:0009615|GO:0007154|GO:0007165|GO:0000422|GO:0016236|GO:0051607|GO:0016021|GO:0006996|GO:0007186|GO:1903008|GO:0098792|GO:0000423|GO:0007005|GO:0004930|GO:0050691|GO:0002230|GO:0098779 signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|response to stress|catabolic process|autophagy|signaling receptor activity|cellular component organization|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|regulation of immune system process|plasma membrane|regulation of defense response to virus|defense response|cellular response to stress|defense response to other organism|transmembrane signaling receptor activity|response to virus|cell communication|signal transduction|mitophagy|macroautophagy|defense response to virus|integral component of membrane|organelle organization|G-protein coupled receptor signaling pathway|organelle disassembly|xenophagy|macromitophagy|mitochondrion organization|G-protein coupled receptor activity|regulation of defense response to virus by host|positive regulation of defense response to virus by host|mitophagy in response to mitochondrial depolarization K08401 G protein-coupled receptor 81[-] hsa04024 cAMP signaling pathway - Homo sapiens (human) 12:122726076-122730843 93 109 130 248 221 292 1.37972305546338 1.46966156696234 1.73887301059386 3.29654750436213 2.69011152852207 4.05994866187235 1.52941921100653 3.34886923158552 -1.13069014105303 4.60450470530445e-05 0.000399485276001625 DOWN ENSG00000049130 KITLG KIT ligand [Source:HGNC Symbol;Acc:HGNC:6343] GO:0040011|GO:0032502|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0050900|GO:0006955|GO:0042698|GO:0044237|GO:0003006|GO:0001776|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0043473|GO:0007155|GO:0071944|GO:0002262|GO:0009605|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0005615|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0022602|GO:0005515|GO:0005886|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0008284|GO:0051272|GO:0042127|GO:1903706|GO:0006935|GO:0045087|GO:0045595|GO:0006725|GO:0070661|GO:0009888|GO:0002685|GO:0048468|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0006952|GO:0048066|GO:0031325|GO:0046483|GO:0033025|GO:2000147|GO:0045597|GO:0048608|GO:0001541|GO:0010243|GO:0005737|GO:0006928|GO:0042592|GO:0002687|GO:0009966|GO:0048568|GO:0007548|GO:0035234|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0008406|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048087|GO:0009725|GO:0008219|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0048070|GO:0009967|GO:0044249|GO:0033026|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0072089|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0005126|GO:0034645|GO:0008584|GO:0050942|GO:0007166|GO:0043412|GO:0008585|GO:0046661|GO:0061458|GO:0030097|GO:0070662|GO:0010623|GO:0043069|GO:1901652|GO:0005125|GO:0000904|GO:0009790|GO:0046545|GO:0071417|GO:0030334|GO:0001667|GO:0051347|GO:0036211|GO:0030856|GO:0048872|GO:1902035|GO:0060485|GO:0043434|GO:0044344|GO:0035162|GO:0051247|GO:0070848|GO:1902033|GO:0030858|GO:0006259|GO:0002764|GO:0032270|GO:0012501|GO:0050931|GO:0060429|GO:0051054|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0048864|GO:0032990|GO:0045639|GO:0007399|GO:0071310|GO:0097485|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0048858|GO:0030335|GO:1902531|GO:0008083|GO:0032870|GO:0005856|GO:0010557|GO:0043067|GO:2000648|GO:0071425|GO:0045637|GO:0097190|GO:0046546|GO:0072091|GO:0048666|GO:0045634|GO:0030182|GO:0002521|GO:0007411|GO:0002761|GO:0001755|GO:0048863|GO:0031401|GO:0006260|GO:0008543|GO:0005173|GO:0030855|GO:1901653|GO:0043408|GO:0070668|GO:0097192|GO:0014031|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0048017|GO:0007167|GO:0071375|GO:0002763|GO:0043410|GO:0006275|GO:0042981|GO:0043066|GO:0045636|GO:0032868|GO:0048762|GO:0030318|GO:0051057|GO:0030099|GO:0045740|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0097191|GO:0043549|GO:0006915|GO:0033674|GO:2000107|GO:0014033|GO:0048011|GO:0000186|GO:0014032|GO:0007265|GO:0002573|GO:0046578|GO:0045859|GO:0048015|GO:0045860|GO:0043406|GO:0007409|GO:0006468|GO:0048699|GO:0046579|GO:0043405|GO:0042325|GO:0033028|GO:0033032|GO:0001932|GO:0032869|GO:0018193|GO:0038093|GO:0001934|GO:0042327|GO:0033033|GO:0007169|GO:0048010|GO:0050731|GO:0050730|GO:0038095|GO:0071902|GO:0060563|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0018108|GO:0007173 locomotion|developmental process|reproduction|immune system process|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|leukocyte migration|immune response|ovulation cycle|cellular metabolic process|developmental process involved in reproduction|leukocyte homeostasis|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|pigmentation|cell adhesion|cell periphery|myeloid cell homeostasis|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|extracellular space|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|ovulation cycle process|protein binding|plasma membrane|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|regulation of hemopoiesis|chemotaxis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|leukocyte proliferation|tissue development|regulation of leukocyte migration|cell development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|defense response|developmental pigmentation|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of mast cell apoptotic process|positive regulation of cell motility|positive regulation of cell differentiation|reproductive structure development|ovarian follicle development|response to organonitrogen compound|cytoplasm|movement of cell or subcellular component|homeostatic process|positive regulation of leukocyte migration|regulation of signal transduction|embryonic organ development|sex differentiation|ectopic germ cell programmed cell death|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|gonad development|cell communication|regulation of cellular component movement|cell migration|signal transduction|positive regulation of developmental pigmentation|response to hormone|cell death|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|regulation of developmental pigmentation|positive regulation of signal transduction|cellular biosynthetic process|negative regulation of mast cell apoptotic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|stem cell proliferation|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|cytokine receptor binding|cellular macromolecule biosynthetic process|male gonad development|positive regulation of pigment cell differentiation|cell surface receptor signaling pathway|macromolecule modification|female gonad development|male sex differentiation|reproductive system development|hemopoiesis|mast cell proliferation|developmental programmed cell death|negative regulation of programmed cell death|response to peptide|cytokine activity|cell morphogenesis involved in differentiation|embryo development|development of primary female sexual characteristics|cellular response to organonitrogen compound|regulation of cell migration|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|regulation of epithelial cell differentiation|homeostasis of number of cells|positive regulation of hematopoietic stem cell proliferation|mesenchyme development|response to peptide hormone|cellular response to fibroblast growth factor stimulus|embryonic hemopoiesis|positive regulation of protein metabolic process|response to growth factor|regulation of hematopoietic stem cell proliferation|positive regulation of epithelial cell differentiation|DNA metabolic process|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|programmed cell death|pigment cell differentiation|epithelium development|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|cell part morphogenesis|positive regulation of myeloid cell differentiation|nervous system development|cellular response to organic substance|neuron projection guidance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|regulation of intracellular signal transduction|growth factor activity|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|positive regulation of stem cell proliferation|hematopoietic stem cell proliferation|regulation of myeloid cell differentiation|apoptotic signaling pathway|development of primary male sexual characteristics|regulation of stem cell proliferation|neuron development|regulation of melanocyte differentiation|neuron differentiation|leukocyte differentiation|axon guidance|regulation of myeloid leukocyte differentiation|neural crest cell migration|stem cell differentiation|positive regulation of protein modification process|DNA replication|fibroblast growth factor receptor signaling pathway|stem cell factor receptor binding|epithelial cell differentiation|cellular response to peptide|regulation of MAPK cascade|positive regulation of mast cell proliferation|extrinsic apoptotic signaling pathway in absence of ligand|mesenchymal cell development|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of myeloid leukocyte differentiation|positive regulation of MAPK cascade|regulation of DNA replication|regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of melanocyte differentiation|response to insulin|mesenchymal cell differentiation|melanocyte differentiation|positive regulation of small GTPase mediated signal transduction|myeloid cell differentiation|positive regulation of DNA replication|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|negative regulation of leukocyte apoptotic process|neural crest cell differentiation|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|neural crest cell development|Ras protein signal transduction|myeloid leukocyte differentiation|regulation of Ras protein signal transduction|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|axonogenesis|protein phosphorylation|generation of neurons|positive regulation of Ras protein signal transduction|regulation of MAP kinase activity|regulation of phosphorylation|myeloid cell apoptotic process|regulation of myeloid cell apoptotic process|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|negative regulation of myeloid cell apoptotic process|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|Fc-epsilon receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|neuroepithelial cell differentiation|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|epidermal growth factor receptor signaling pathway K05461 KIT ligand[-] hsa05200|hsa04151|hsa04060|hsa04014|hsa04015|hsa04072|hsa04916|hsa04640 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human) 12:88492793-88580851 198 252 280 766 881 322 1.86397498978249 2.15602876283278 2.37654875174389 6.46101490861355 6.80484660490017 2.84092223158644 2.13218416811972 5.36892791503339 -1.33230197819199 4.60709463157467e-05 0.000399593849886782 DOWN ENSG00000171476 HOPX HOP homeobox [Source:HGNC Symbol;Acc:HGNC:24961] GO:0032502|GO:0040007|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0045927|GO:0043227|GO:0040008|GO:0009605|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0001824|GO:0048286|GO:0045595|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0007275|GO:0030324|GO:0016570|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0046483|GO:0042246|GO:0001825|GO:0051098|GO:0061061|GO:0045597|GO:0043231|GO:0009611|GO:0009890|GO:0048639|GO:0030323|GO:0006139|GO:0048638|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0003013|GO:0006996|GO:0051276|GO:0003677|GO:0051149|GO:0010468|GO:0034645|GO:0043412|GO:0072358|GO:0010629|GO:0042692|GO:0051252|GO:0060541|GO:0006325|GO:0009790|GO:0051147|GO:0036211|GO:0042060|GO:0043403|GO:0044267|GO:0010467|GO:0009059|GO:0030154|GO:0043415|GO:0016070|GO:0072359|GO:0008015|GO:0016575|GO:0005634|GO:0001829|GO:0090303|GO:0043393|GO:0008016|GO:0051153|GO:0009792|GO:0045892|GO:0032774|GO:0060047|GO:2001141|GO:1902679|GO:0051146|GO:0016568|GO:0006464|GO:0051155|GO:0006351|GO:0006355|GO:0061041|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0043009|GO:0000122|GO:0006476|GO:0001701 developmental process|growth|cell|cellular process|metabolic process|response to stimulus|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|membrane-bounded organelle|regulation of growth|response to external stimulus|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|blastocyst development|lung alveolus development|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|multicellular organism development|lung development|histone modification|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|tissue regeneration|blastocyst formation|regulation of binding|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|response to wounding|negative regulation of biosynthetic process|positive regulation of developmental growth|respiratory tube development|nucleobase-containing compound metabolic process|regulation of developmental growth|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|organelle organization|chromosome organization|DNA binding|positive regulation of muscle cell differentiation|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|cardiovascular system development|negative regulation of gene expression|muscle cell differentiation|regulation of RNA metabolic process|respiratory system development|chromatin organization|embryo development|regulation of muscle cell differentiation|protein modification process|wound healing|skeletal muscle tissue regeneration|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|positive regulation of skeletal muscle tissue regeneration|RNA metabolic process|circulatory system development|blood circulation|histone deacetylation|nucleus|trophectodermal cell differentiation|positive regulation of wound healing|regulation of protein binding|regulation of heart contraction|regulation of striated muscle cell differentiation|embryo development ending in birth or egg hatching|negative regulation of transcription, DNA-templated|RNA biosynthetic process|heart contraction|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|striated muscle cell differentiation|chromatin modification|cellular protein modification process|positive regulation of striated muscle cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of wound healing|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|protein deacetylation|in utero embryonic development - - - - 4:56647988-56681899 0 0 0 4 5 11 0 0 0 0.0204503839983334 0.023408880795668 0.0588217888122369 0 0.0342270178687461 -Inf 4.65289570050367e-05 0.000403097934541023 DOWN ENSG00000276272 RP11-121C6.5 - - - - - - - 12:56411944-56413190 15 10 8 2 3 0 0.85087135099994 0.515535702318119 0.409161520427994 0.101653332168139 0.139640386049819 0 0.591856191248684 0.080431239405986 2.87941881698067 4.65655685659046e-05 0.000403298080640127 UP ENSG00000020577 SAMD4A sterile alpha motif domain containing 4A [Source:HGNC Symbol;Acc:HGNC:23023] GO:0045202|GO:0005623|GO:0045182|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0030371|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0005737|GO:0043005|GO:0009890|GO:0036477|GO:0006139|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0010629|GO:0051252|GO:0010628|GO:0032269|GO:0030425|GO:0051247|GO:0032270|GO:0043603|GO:0044267|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0016070|GO:0010557|GO:0043043|GO:0032774|GO:0017148|GO:2001141|GO:0045727|GO:0010608|GO:0006412|GO:0006417|GO:0044822|GO:0006351|GO:0006355|GO:1903506 synapse|cell|translation regulator activity|cellular process|metabolic process|cell junction|binding|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|translation repressor activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cytoplasm|neuron projection|negative regulation of biosynthetic process|somatodendritic compartment|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|negative regulation of cellular protein metabolic process|dendrite|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|peptide biosynthetic process|RNA biosynthetic process|negative regulation of translation|regulation of RNA biosynthetic process|positive regulation of translation|posttranscriptional regulation of gene expression|translation|regulation of translation|poly(A) RNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 14:54567097-54793315 39 36 215 452 351 455 0.13057738185269 0.109544321240427 0.649023243401706 1.35595132319348 0.964236122422435 1.4277380627341 0.296381648831608 1.24930850278334 -2.07560175071163 4.68144836445443e-05 0.000405218786524855 DOWN ENSG00000237172 B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 [Source:HGNC Symbol;Acc:HGNC:28714] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0043231|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0043412|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0008378|GO:0006464 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|macromolecule modification|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|galactosyltransferase activity|cellular protein modification process - - - - 16:67148105-67151214 67 108 77 203 203 207 1.62474481688317 2.38019493470672 1.68351384340635 4.41066037394897 4.03898543740741 4.70443664559386 1.89615119833208 4.38469415231675 -1.20940220443354 4.69864195683861e-05 0.000406589150665101 DOWN ENSG00000164045 CDC25A cell division cycle 25A [Source:HGNC Symbol;Acc:HGNC:1725] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009628|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0009314|GO:0022402|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0006139|GO:0050790|GO:0051301|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0032268|GO:0005829|GO:0034645|GO:1903047|GO:0043412|GO:0044770|GO:0036211|GO:0000278|GO:0031981|GO:0000087|GO:0071478|GO:0005654|GO:0006259|GO:0019900|GO:0006796|GO:0044267|GO:0051174|GO:0007067|GO:0051246|GO:0009059|GO:0005634|GO:0009416|GO:0042578|GO:0016311|GO:0006260|GO:0009411|GO:0000086|GO:0044772|GO:0016310|GO:0071482|GO:0016791|GO:0019901|GO:0006464|GO:0000079|GO:0043549|GO:0006470|GO:0045859|GO:0006468|GO:0042325|GO:0004721|GO:0001932|GO:0000082|GO:0034644|GO:0035335|GO:0071900|GO:0004725 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|response to radiation|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|nucleobase-containing compound metabolic process|regulation of catalytic activity|cell division|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cytosol|cellular macromolecule biosynthetic process|mitotic cell cycle process|macromolecule modification|cell cycle phase transition|protein modification process|mitotic cell cycle|nuclear lumen|mitotic M phase|cellular response to radiation|nucleoplasm|DNA metabolic process|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|response to light stimulus|phosphoric ester hydrolase activity|dephosphorylation|DNA replication|response to UV|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|phosphorylation|cellular response to light stimulus|phosphatase activity|protein kinase binding|cellular protein modification process|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|protein dephosphorylation|regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|phosphoprotein phosphatase activity|regulation of protein phosphorylation|G1/S transition of mitotic cell cycle|cellular response to UV|peptidyl-tyrosine dephosphorylation|regulation of protein serine/threonine kinase activity|protein tyrosine phosphatase activity K06645 M-phase inducer phosphatase 1[3.1.3.48] hsa05206|hsa04110|hsa04914 MicroRNAs in cancer - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human) 3:48157146-48188402 1047 1057 540 446 498 213 14.4510151893848 13.2588818676195 6.71985958041497 5.5154923881888 5.63960804819256 2.75524423106615 11.4765855458064 4.63678155581584 1.30749781632597 4.71742946060086e-05 0.00040780722861375 UP ENSG00000005059 CCDC109B coiled-coil domain containing 109B [Source:HGNC Symbol;Acc:HGNC:26076] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043229|GO:0051641|GO:0043227|GO:0031224|GO:0016247|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0019866|GO:0006810|GO:0043231|GO:0005737|GO:0005246|GO:0042592|GO:0031966|GO:0019725|GO:1902495|GO:0055085|GO:0051649|GO:0016021|GO:0031301|GO:0016248|GO:0005740|GO:1990246|GO:0019855|GO:0048878|GO:0008200|GO:0046907|GO:0006811|GO:0055082|GO:0005743|GO:0031304|GO:0034702|GO:0005739|GO:0032592|GO:0034220|GO:0036444|GO:0098655|GO:0006839|GO:0034703|GO:0006812|GO:0031305|GO:0050801|GO:0006873|GO:0006851|GO:0034704|GO:0030001|GO:0030003|GO:0070588|GO:0055065|GO:0006875|GO:0006874|GO:0006816|GO:0055074|GO:0051560|GO:0070509 macromolecular complex|cell|membrane|cellular process|binding|intracellular organelle|cellular localization|membrane-bounded organelle|intrinsic component of membrane|channel regulator activity|intracellular|protein binding|protein complex|organelle membrane|organelle inner membrane|transport|intracellular membrane-bounded organelle|cytoplasm|calcium channel regulator activity|homeostatic process|mitochondrial membrane|cellular homeostasis|transmembrane transporter complex|transmembrane transport|establishment of localization in cell|integral component of membrane|integral component of organelle membrane|channel inhibitor activity|mitochondrial envelope|uniplex complex|calcium channel inhibitor activity|chemical homeostasis|ion channel inhibitor activity|intracellular transport|ion transport|cellular chemical homeostasis|mitochondrial inner membrane|intrinsic component of mitochondrial inner membrane|ion channel complex|mitochondrion|integral component of mitochondrial membrane|ion transmembrane transport|calcium ion transmembrane import into mitochondrion|cation transmembrane transport|mitochondrial transport|cation channel complex|cation transport|integral component of mitochondrial inner membrane|ion homeostasis|cellular ion homeostasis|mitochondrial calcium ion transport|calcium channel complex|metal ion transport|cellular cation homeostasis|calcium ion transmembrane transport|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|mitochondrial calcium ion homeostasis|calcium ion import - - - - 4:109560205-109688726 168 188 285 454 467 438 2.44773813859586 2.48939501356644 3.74381960997123 5.92666226783157 5.58266630087683 5.98080810431749 2.89365092071118 5.8300455576753 -1.0106162661087 4.73234184042954e-05 0.000408794367199605 DOWN ENSG00000103942 HOMER2 homer scaffolding protein 2 [Source:HGNC Symbol;Acc:HGNC:17513] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0060076|GO:0043229|GO:0044297|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0097060|GO:0042802|GO:0043025|GO:0005102|GO:0045211|GO:0043231|GO:0005737|GO:0043005|GO:0046983|GO:0036477|GO:0014069|GO:0019904|GO:0007154|GO:0007165|GO:0005730|GO:0007186|GO:0007166|GO:0046982|GO:0031981|GO:0030425|GO:0001664|GO:0005634|GO:0042803|GO:0035254|GO:0007216|GO:0007215|GO:0035256 synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|excitatory synapse|intracellular organelle|cell body|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|synaptic membrane|identical protein binding|neuronal cell body|receptor binding|postsynaptic membrane|intracellular membrane-bounded organelle|cytoplasm|neuron projection|protein dimerization activity|somatodendritic compartment|postsynaptic density|protein domain specific binding|cell communication|signal transduction|nucleolus|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|protein heterodimerization activity|nuclear lumen|dendrite|G-protein coupled receptor binding|nucleus|protein homodimerization activity|glutamate receptor binding|G-protein coupled glutamate receptor signaling pathway|glutamate receptor signaling pathway|G-protein coupled glutamate receptor binding K15010 homer[-] hsa04068|hsa04724 FoxO signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human) 15:82836946-82986153 46 45 108 154 187 222 0.202179471698359 0.179753884566671 0.427974982638489 0.606457730234393 0.674357880515118 0.914456872708082 0.269969446301173 0.731757494485864 -1.43856947644657 4.73918159078271e-05 0.000409266783949167 DOWN ENSG00000170468 C14orf169 chromosome 14 open reading frame 169 [Source:HGNC Symbol;Acc:HGNC:20968] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0032451|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0019222|GO:0045595|GO:0006725|GO:0051213|GO:1901360|GO:0016570|GO:0045596|GO:0030279|GO:0034641|GO:0032452|GO:0046483|GO:0006482|GO:0043231|GO:0043169|GO:0016705|GO:0070988|GO:0009890|GO:0006139|GO:0030278|GO:0001503|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0055114|GO:0051276|GO:0005730|GO:0051864|GO:0010468|GO:0034645|GO:0046872|GO:0045668|GO:0032453|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0045667|GO:0036211|GO:0001649|GO:0031981|GO:0016706|GO:0005654|GO:0016577|GO:0044267|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0070076|GO:0046914|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0034720|GO:0005506|GO:1903507|GO:1903506|GO:0070544 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|demethylase activity|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|protein binding|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|dioxygenase activity|organic cyclic compound metabolic process|histone modification|negative regulation of cell differentiation|negative regulation of ossification|cellular nitrogen compound metabolic process|histone demethylase activity|heterocycle metabolic process|protein demethylation|intracellular membrane-bounded organelle|cation binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|demethylation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|regulation of ossification|ossification|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|chromosome organization|nucleolus|histone demethylase activity (H3-K36 specific)|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of osteoblast differentiation|histone demethylase activity (H3-K4 specific)|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|regulation of osteoblast differentiation|protein modification process|osteoblast differentiation|nuclear lumen|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|nucleoplasm|histone demethylation|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|histone lysine demethylation|transition metal ion binding|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|histone H3-K4 demethylation|iron ion binding|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|histone H3-K36 demethylation - - - - 14:73490964-73493392 1138 1253 465 443 485 325 33.1406222762861 33.1626516175577 12.2091505032539 11.5589905272759 11.5885212089271 8.87013045873761 26.1708081323659 10.6725473983135 1.29405390445809 4.74948775709633e-05 0.000409919651634443 UP ENSG00000148120 C9orf3 chromosome 9 open reading frame 3 [Source:HGNC Symbol;Acc:HGNC:1361] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0033218|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0005622|GO:0005886|GO:0044255|GO:0042277|GO:0006082|GO:0034641|GO:0044281|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0006629|GO:0044249|GO:0019538|GO:0005730|GO:0006518|GO:0046872|GO:0043171|GO:0006631|GO:0031981|GO:0006508|GO:0043603|GO:0008610|GO:0005634|GO:0006690|GO:0008237|GO:0033559|GO:0006691|GO:0006633|GO:0008238|GO:0046914|GO:0019752|GO:0046456|GO:0006636|GO:0019370|GO:0008235|GO:0032787|GO:0004177|GO:0008270|GO:0070006 cell|membrane|cellular process|metabolic process|binding|catalytic activity|amide binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intracellular|plasma membrane|cellular lipid metabolic process|peptide binding|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|lipid metabolic process|cellular biosynthetic process|protein metabolic process|nucleolus|peptide metabolic process|metal ion binding|peptide catabolic process|fatty acid metabolic process|nuclear lumen|proteolysis|cellular amide metabolic process|lipid biosynthetic process|nucleus|icosanoid metabolic process|metallopeptidase activity|unsaturated fatty acid metabolic process|leukotriene metabolic process|fatty acid biosynthetic process|exopeptidase activity|transition metal ion binding|carboxylic acid metabolic process|icosanoid biosynthetic process|unsaturated fatty acid biosynthetic process|leukotriene biosynthetic process|metalloexopeptidase activity|monocarboxylic acid metabolic process|aminopeptidase activity|zinc ion binding|metalloaminopeptidase activity - - - - 9:94726701-95087218 143 187 121 365 374 327 0.623791098834752 0.74135149934903 0.475882503229172 1.4265669538631 1.33857237169275 1.33683947285271 0.613675033804318 1.36732626613619 -1.15581073787379 4.75856790593794e-05 0.000410466010586164 DOWN ENSG00000189283 FHIT fragile histidine triad [Source:HGNC Symbol;Acc:HGNC:3701] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0006725|GO:1901360|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0016817|GO:0043231|GO:0019899|GO:0005737|GO:0006139|GO:0055086|GO:0007154|GO:0007165|GO:0070062|GO:0008219|GO:0000166|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0030163|GO:0051252|GO:0044265|GO:0016818|GO:0032269|GO:0006508|GO:0005739|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0042176|GO:0010467|GO:0051246|GO:0009059|GO:0016070|GO:0042177|GO:0005634|GO:0097190|GO:0044389|GO:0031625|GO:0044257|GO:0097193|GO:0010498|GO:0009117|GO:0072331|GO:0032774|GO:1903363|GO:0030162|GO:2001141|GO:0051603|GO:0006163|GO:0045861|GO:0016462|GO:0006351|GO:0006915|GO:0006355|GO:0072332|GO:0019941|GO:1903506|GO:1901799|GO:0004551|GO:1903051|GO:0061136|GO:0043161|GO:0006511|GO:0047710|GO:0032434|GO:0032435 signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|regulation of metabolic process|identical protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|extracellular exosome|cell death|nucleotide binding|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|protein catabolic process|regulation of RNA metabolic process|cellular macromolecule catabolic process|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|negative regulation of cellular protein metabolic process|proteolysis|mitochondrion|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of protein catabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|negative regulation of protein catabolic process|nucleus|apoptotic signaling pathway|ubiquitin-like protein ligase binding|ubiquitin protein ligase binding|cellular protein catabolic process|intrinsic apoptotic signaling pathway|proteasomal protein catabolic process|nucleotide metabolic process|signal transduction by p53 class mediator|RNA biosynthetic process|negative regulation of cellular protein catabolic process|regulation of proteolysis|regulation of RNA biosynthetic process|proteolysis involved in cellular protein catabolic process|purine nucleotide metabolic process|negative regulation of proteolysis|pyrophosphatase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway by p53 class mediator|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|negative regulation of proteasomal protein catabolic process|nucleotide diphosphatase activity|negative regulation of proteolysis involved in cellular protein catabolic process|regulation of proteasomal protein catabolic process|proteasome-mediated ubiquitin-dependent protein catabolic process|ubiquitin-dependent protein catabolic process|bis(5'-adenosyl)-triphosphatase activity|regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of proteasomal ubiquitin-dependent protein catabolic process K01522 bis(5'-adenosyl)-triphosphatase[3.6.1.29] hsa00230|hsa05222|hsa05223 Purine metabolism - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human) 3:59749310-61251459 3 1 6 15 18 25 0.0277829322318293 0.00841965266879688 0.0500940322005866 0.124450939913143 0.136755220019227 0.216959704764257 0.0287655390337376 0.159388621565542 -2.47013523182997 4.78399889029803e-05 0.000412421319292398 DOWN ENSG00000132749 MTL5 metallothionein-like 5, testis-specific (tesmin) [Source:HGNC Symbol;Acc:HGNC:7446] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0043229|GO:0044702|GO:0043167|GO:0019953|GO:0043227|GO:0032504|GO:0005622|GO:0048856|GO:0048609|GO:0007275|GO:0043231|GO:0043169|GO:0005737|GO:0042592|GO:0019725|GO:0007276|GO:0048869|GO:0010035|GO:0048232|GO:0046872|GO:0048878|GO:0010038|GO:0055082|GO:0030154|GO:0005634|GO:0007283|GO:0050801|GO:0006873|GO:0030003|GO:0055065|GO:0006875 developmental process|reproduction|cell|cellular process|reproductive process|response to stimulus|binding|intracellular organelle|single organism reproductive process|ion binding|sexual reproduction|membrane-bounded organelle|multicellular organism reproduction|intracellular|anatomical structure development|multicellular organismal reproductive process|multicellular organism development|intracellular membrane-bounded organelle|cation binding|cytoplasm|homeostatic process|cellular homeostasis|gamete generation|cellular developmental process|response to inorganic substance|male gamete generation|metal ion binding|chemical homeostasis|response to metal ion|cellular chemical homeostasis|cell differentiation|nucleus|spermatogenesis|ion homeostasis|cellular ion homeostasis|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis - - - - 11:68707440-68751564 85 75 123 191 228 258 0.690712352080881 0.553886051761985 0.901144948461537 1.39061758524149 1.52012866134829 1.96482915680222 0.715247784101468 1.62519180113067 -1.18409496342579 4.83007471755037e-05 0.000416153104235927 DOWN ENSG00000136002 ARHGEF4 Rho guanine nucleotide exchange factor 4 [Source:HGNC Symbol;Acc:HGNC:684] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0023051|GO:0016043|GO:0071944|GO:0009893|GO:0031252|GO:0005622|GO:0005515|GO:0005886|GO:0005085|GO:0019222|GO:0010941|GO:0022607|GO:0010942|GO:0005737|GO:0001726|GO:0005088|GO:0009966|GO:0019904|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0008219|GO:0031256|GO:0050790|GO:0030030|GO:0031253|GO:0010033|GO:0005829|GO:0007166|GO:0051345|GO:0030031|GO:0070848|GO:0032587|GO:0012501|GO:0097581|GO:0035556|GO:0071310|GO:0005089|GO:0043068|GO:1902531|GO:0043067|GO:0097190|GO:0030032|GO:0043065|GO:0030676|GO:0071363|GO:0043087|GO:0038179|GO:0043547|GO:0007167|GO:0046847|GO:0042981|GO:0051056|GO:0007264|GO:0006915|GO:0048011|GO:0007265|GO:0046578|GO:0007169|GO:0035023|GO:0007266 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|regulation of signaling|cellular component organization|cell periphery|positive regulation of metabolic process|cell leading edge|intracellular|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|regulation of metabolic process|regulation of cell death|cellular component assembly|positive regulation of cell death|cytoplasm|ruffle|Ras guanyl-nucleotide exchange factor activity|regulation of signal transduction|protein domain specific binding|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|cell death|leading edge membrane|regulation of catalytic activity|cell projection organization|cell projection membrane|response to organic substance|cytosol|cell surface receptor signaling pathway|positive regulation of hydrolase activity|cell projection assembly|response to growth factor|ruffle membrane|programmed cell death|lamellipodium organization|intracellular signal transduction|cellular response to organic substance|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|regulation of programmed cell death|apoptotic signaling pathway|lamellipodium assembly|positive regulation of apoptotic process|Rac guanyl-nucleotide exchange factor activity|cellular response to growth factor stimulus|regulation of GTPase activity|neurotrophin signaling pathway|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|filopodium assembly|regulation of apoptotic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|apoptotic process|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction K05769 Rho guanine nucleotide exchange factor 4[-] hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) 2:130836916-131047263 57 77 154 213 259 312 0.21122000840367 0.259319644022538 0.514513752112679 0.707194757120093 0.787462221869493 1.08354348984299 0.328351134846296 0.859400156277525 -1.3880905979713 4.87446443674513e-05 0.000419614363594548 DOWN ENSG00000131873 CHSY1 chondroitin sulfate synthase 1 [Source:HGNC Symbol;Acc:HGNC:17198] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0009653|GO:0043227|GO:0009605|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0009888|GO:0048468|GO:0006082|GO:0009991|GO:0007275|GO:0048513|GO:0030279|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0007389|GO:0005975|GO:0009887|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0030278|GO:0001503|GO:0016757|GO:0060348|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0048705|GO:0034645|GO:0051216|GO:0046872|GO:0007166|GO:0008194|GO:0002063|GO:0045880|GO:0008589|GO:0030204|GO:0009100|GO:0003002|GO:0016758|GO:0005795|GO:1901137|GO:0060349|GO:0000139|GO:0051923|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0031667|GO:0009101|GO:0002062|GO:0030206|GO:0007224|GO:0031985|GO:0015020|GO:0050650|GO:0032580|GO:0006024|GO:0006029|GO:0030203|GO:0009954|GO:0008376|GO:0047238|GO:0030166|GO:0050510 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|response to external stimulus|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|anatomical structure development|organelle membrane|tissue development|cell development|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|animal organ development|negative regulation of ossification|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|pattern specification process|carbohydrate metabolic process|organ morphogenesis|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|regulation of ossification|ossification|transferase activity, transferring glycosyl groups|bone development|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|skeletal system morphogenesis|cellular macromolecule biosynthetic process|cartilage development|metal ion binding|cell surface receptor signaling pathway|UDP-glycosyltransferase activity|chondrocyte development|positive regulation of smoothened signaling pathway|regulation of smoothened signaling pathway|chondroitin sulfate metabolic process|glycoprotein metabolic process|regionalization|transferase activity, transferring hexosyl groups|Golgi stack|carbohydrate derivative biosynthetic process|bone morphogenesis|Golgi membrane|sulfation|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|response to nutrient levels|glycoprotein biosynthetic process|chondrocyte differentiation|chondroitin sulfate biosynthetic process|smoothened signaling pathway|Golgi cisterna|glucuronosyltransferase activity|chondroitin sulfate proteoglycan biosynthetic process|Golgi cisterna membrane|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|glycosaminoglycan metabolic process|proximal/distal pattern formation|acetylgalactosaminyltransferase activity|glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|proteoglycan biosynthetic process|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity K13499 chondroitin sulfate synthase[2.4.1.226] hsa01100|hsa00532 Metabolic pathways - Homo sapiens (human)|Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human) 15:101175723-101251932 85 87 88 169 224 219 0.70126557322884 0.652323968455437 0.6545760530678 1.24924322841017 1.51627305902128 1.69330670319929 0.669388531584026 1.48627433021025 -1.15078468786051 4.88045699331786e-05 0.000419767107688019 DOWN ENSG00000172296 SPTLC3 serine palmitoyltransferase, long chain base subunit 3 [Source:HGNC Symbol;Acc:HGNC:16253] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0043168|GO:0044281|GO:0043231|GO:0016746|GO:0005737|GO:0006629|GO:0005783|GO:0030170|GO:0016021|GO:0044249|GO:0006665|GO:0006643|GO:0017059|GO:0008483|GO:1990234|GO:0016747|GO:0008610|GO:0002178|GO:0016409|GO:0030148|GO:0046520|GO:0004758 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein complex|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|lipid metabolic process|endoplasmic reticulum|pyridoxal phosphate binding|integral component of membrane|cellular biosynthetic process|sphingolipid metabolic process|membrane lipid metabolic process|serine C-palmitoyltransferase complex|transaminase activity|transferase complex|transferase activity, transferring acyl groups other than amino-acyl groups|lipid biosynthetic process|palmitoyltransferase complex|palmitoyltransferase activity|sphingolipid biosynthetic process|sphingoid biosynthetic process|serine C-palmitoyltransferase activity K00654 serine palmitoyltransferase[2.3.1.50] hsa01100|hsa04071|hsa00600 Metabolic pathways - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human) 20:13008979-13169103 78 101 189 302 289 321 0.571522990858967 0.672575920307011 1.24857587111944 1.98263686608076 1.73741533077079 2.20430949893959 0.830891594095139 1.97478723193038 -1.24896505554702 4.88606261086569e-05 0.000420128206177374 DOWN ENSG00000188185 LINC00265 long intergenic non-protein coding RNA 265 [Source:HGNC Symbol;Acc:HGNC:28019] - - - - - - 7:39733632-39793092 56 85 63 31 32 27 1.18993040190566 1.64146924042619 1.20694417340413 0.59018031045173 0.557888129712891 0.537676982712404 1.34611460524533 0.561915140959008 1.26037706331328 4.89687507247283e-05 0.000420936678415214 UP ENSG00000218226 TATDN2P2 TatD DNase domain containing 2 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:39255] - - - - - - 6:158609706-158621636 32 55 65 121 124 143 1.01689422113166 1.58842409658881 1.8622970607618 3.44510091350979 3.2330457272984 4.25878722990589 1.48920512616076 3.64564462357136 -1.29163144734411 4.90799594739237e-05 0.000421771188870039 DOWN ENSG00000226318 RP11-474D14.2 - - - - - - - 10:67960702-67961464 1 0 4 12 9 23 0.0927479599247888 0 0.334354138908066 0.996815506267387 0.684582651197168 1.99840588982794 0.142367366277618 1.2266013490975 -3.10697605089189 4.91653892149543e-05 0.000422263673227178 DOWN ENSG00000260269 CTD-2323K18.1 - - - - - - - 15:75527150-75601205 27 59 38 12 15 16 1.49914096626672 2.97722232913891 1.90227568879229 0.596993902105194 0.683359250919692 0.832584740615615 2.12621299473264 0.7043126312135 1.59399826548755 4.91655566469374e-05 0.000422263673227178 UP ENSG00000175730 BAK1P1 BCL2-antagonist/killer 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:996] - - - - - - 20:32690180-32690815 65 62 48 18 33 19 7.22942374992433 6.26700114607281 4.81333293630269 1.79369690048896 3.01143523804806 1.98045628251171 6.10325261076661 2.26186280701624 1.43206687861083 4.92171831450969e-05 0.000422585500607916 UP ENSG00000279488 AC004623.3 - - - - - - - 19:1372238-1374364 19 37 40 14 8 8 0.631862165721479 1.11831716106415 1.19936780983301 0.417175334506669 0.218303458687362 0.249344842394051 0.98318237887288 0.294941211862694 1.73703163625216 4.93378889942919e-05 0.000423500097192521 UP ENSG00000068383 INPP5A inositol polyphosphate-5-phosphatase A [Source:HGNC Symbol;Acc:HGNC:6076] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0016787|GO:0005515|GO:0005886|GO:0044255|GO:0043647|GO:0016788|GO:0044281|GO:0031982|GO:0019637|GO:0019904|GO:0006629|GO:0070062|GO:0042731|GO:0046486|GO:0006066|GO:0006796|GO:0030258|GO:0042578|GO:0006644|GO:0016311|GO:0046839|GO:0016791|GO:0006650|GO:0046488|GO:0046856|GO:0052745|GO:0046030|GO:0052659|GO:0052658|GO:0004445 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|hydrolase activity|protein binding|plasma membrane|cellular lipid metabolic process|inositol phosphate metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|organophosphate metabolic process|protein domain specific binding|lipid metabolic process|extracellular exosome|PH domain binding|glycerolipid metabolic process|alcohol metabolic process|phosphate-containing compound metabolic process|lipid modification|phosphoric ester hydrolase activity|phospholipid metabolic process|dephosphorylation|phospholipid dephosphorylation|phosphatase activity|glycerophospholipid metabolic process|phosphatidylinositol metabolic process|phosphatidylinositol dephosphorylation|inositol phosphate phosphatase activity|inositol trisphosphate phosphatase activity|inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity K01106 inositol-1,4,5-trisphosphate 5-phosphatase[3.1.3.56] hsa01100|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) 10:132537820-132783480 161 177 281 422 436 480 2.35886507700317 2.35685229756694 3.7119301463913 5.53973118167266 5.24122626619267 6.59096463050489 2.80921584032047 5.79064069279007 -1.04355550565841 4.96748025795992e-05 0.000426146998911309 DOWN ENSG00000260852 FBXL19-AS1 FBXL19 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:27557] - - - - - - 16:30919319-30923269 16 25 17 52 64 58 0.286459951434963 0.406786377280336 0.274409898700901 0.834137205550826 0.940121277557182 0.973188268580223 0.3225520758054 0.915815583896077 -1.50552501327634 4.97666439914658e-05 0.00042681223490986 DOWN ENSG00000147059 SPIN2A spindlin family member 2A [Source:HGNC Symbol;Acc:HGNC:20694] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0050794|GO:0043229|GO:0044702|GO:0019953|GO:0043227|GO:0032504|GO:0005622|GO:0048609|GO:0051726|GO:0007049|GO:0043231|GO:0007276|GO:0005634 reproduction|cell|cellular process|reproductive process|regulation of cellular process|intracellular organelle|single organism reproductive process|sexual reproduction|membrane-bounded organelle|multicellular organism reproduction|intracellular|multicellular organismal reproductive process|regulation of cell cycle|cell cycle|intracellular membrane-bounded organelle|gamete generation|nucleus - - - - X:57134530-57137625 0 0 0 8 5 5 0 0 0 0.106679322712956 0.061056153003134 0.0697452648093819 0 0.079160246841824 -Inf 4.98829820854417e-05 0.000427687118661338 DOWN ENSG00000136235 GPNMB glycoprotein (transmembrane) nmb [Source:HGNC Symbol;Acc:HGNC:4462] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0043167|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0001818|GO:0042127|GO:0008201|GO:0009888|GO:0007275|GO:0048513|GO:0005102|GO:0043168|GO:0031982|GO:0001817|GO:0005887|GO:0043231|GO:0005737|GO:0001816|GO:0032403|GO:0050839|GO:0031226|GO:0001503|GO:0008285|GO:0048869|GO:0016021|GO:0005539|GO:0031410|GO:1903556|GO:0031214|GO:0016023|GO:0005178|GO:0001649|GO:0031988|GO:0030154|GO:0030282|GO:0032680|GO:0032720|GO:0032640|GO:0042470 developmental process|cell|membrane|cellular process|binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|ion binding|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|negative regulation of cytokine production|regulation of cell proliferation|heparin binding|tissue development|multicellular organism development|animal organ development|receptor binding|anion binding|vesicle|regulation of cytokine production|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|cytokine production|protein complex binding|cell adhesion molecule binding|intrinsic component of plasma membrane|ossification|negative regulation of cell proliferation|cellular developmental process|integral component of membrane|glycosaminoglycan binding|cytoplasmic vesicle|negative regulation of tumor necrosis factor superfamily cytokine production|biomineral tissue development|cytoplasmic, membrane-bounded vesicle|integrin binding|osteoblast differentiation|membrane-bounded vesicle|cell differentiation|bone mineralization|regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor production|tumor necrosis factor production|melanosome - - - - 7:23235967-23275108 38 23 57 12 3 15 0.251544816950034 0.13837154898713 0.340187988141687 0.0711744554821277 0.0162952986528284 0.0930588821043024 0.243368118026284 0.0601762120797528 2.01587498181224 5.06417297131643e-05 0.000433569887828164 UP ENSG00000136630 HLX H2.0-like homeobox [Source:HGNC Symbol;Acc:HGNC:4978] GO:0032502|GO:0040007|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0002683|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0006955|GO:0044237|GO:0009653|GO:0045927|GO:0007155|GO:0043227|GO:0040008|GO:0009058|GO:0002684|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0002250|GO:1903706|GO:0048565|GO:0016337|GO:0002286|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0050867|GO:0035295|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0070489|GO:0034641|GO:0046620|GO:0030155|GO:0046483|GO:0042092|GO:0035265|GO:0098609|GO:0061061|GO:0045597|GO:0043231|GO:0009887|GO:0002696|GO:0001775|GO:0048598|GO:0002263|GO:0048568|GO:0048639|GO:0006139|GO:0007162|GO:0050776|GO:0046649|GO:0050865|GO:0046622|GO:0002366|GO:0050778|GO:0048638|GO:0045785|GO:0050777|GO:0002695|GO:0048869|GO:0044249|GO:0031323|GO:0002292|GO:0048732|GO:0051249|GO:0003677|GO:0010468|GO:0034645|GO:0055123|GO:0030097|GO:0030098|GO:0048483|GO:0051252|GO:0045064|GO:0034109|GO:0045623|GO:0045622|GO:0009790|GO:0001889|GO:0002829|GO:0060537|GO:0002828|GO:0051251|GO:0051250|GO:0022408|GO:0022407|GO:0007159|GO:0048484|GO:0002821|GO:0002460|GO:0042110|GO:0045624|GO:0010467|GO:0048562|GO:0007399|GO:0002819|GO:0009059|GO:0030154|GO:0022409|GO:0042093|GO:0007517|GO:0048566|GO:0048546|GO:0016070|GO:0005634|GO:0002521|GO:1903038|GO:0060538|GO:0045627|GO:0045629|GO:0045625|GO:0050863|GO:0045620|GO:0032774|GO:0043565|GO:0050868|GO:2001141|GO:0030217|GO:0045619|GO:0034112|GO:0070486|GO:0046631|GO:0048557|GO:0042088|GO:0034111|GO:0014706|GO:0045063|GO:0050870|GO:0045621|GO:0006351|GO:0006355|GO:1903039|GO:0045582|GO:0046632|GO:0007519|GO:0045580|GO:1903506|GO:0045581|GO:0046636|GO:0035710|GO:0071593|GO:0002827|GO:0046638|GO:0043367|GO:0046639|GO:2000516|GO:0043372|GO:0043370 developmental process|growth|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|negative regulation of immune system process|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|immune response|cellular metabolic process|anatomical structure morphogenesis|positive regulation of growth|cell adhesion|membrane-bounded organelle|regulation of growth|biosynthetic process|positive regulation of immune system process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|adaptive immune response|regulation of hemopoiesis|digestive tract development|single organismal cell-cell adhesion|T cell activation involved in immune response|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|positive regulation of cell activation|tube development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|regulation of organ growth|regulation of cell adhesion|heterocycle metabolic process|type 2 immune response|organ growth|cell-cell adhesion|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|organ morphogenesis|positive regulation of leukocyte activation|cell activation|embryonic morphogenesis|cell activation involved in immune response|embryonic organ development|positive regulation of developmental growth|nucleobase-containing compound metabolic process|negative regulation of cell adhesion|regulation of immune response|lymphocyte activation|regulation of cell activation|positive regulation of organ growth|leukocyte activation involved in immune response|positive regulation of immune response|regulation of developmental growth|positive regulation of cell adhesion|negative regulation of immune response|negative regulation of leukocyte activation|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|T cell differentiation involved in immune response|gland development|regulation of lymphocyte activation|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|digestive system development|hemopoiesis|lymphocyte differentiation|autonomic nervous system development|regulation of RNA metabolic process|T-helper 2 cell differentiation|homotypic cell-cell adhesion|negative regulation of T-helper cell differentiation|regulation of T-helper cell differentiation|embryo development|liver development|negative regulation of type 2 immune response|muscle tissue development|regulation of type 2 immune response|positive regulation of lymphocyte activation|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|enteric nervous system development|positive regulation of adaptive immune response|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|T cell activation|positive regulation of T-helper cell differentiation|gene expression|embryonic organ morphogenesis|nervous system development|regulation of adaptive immune response|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|T-helper cell differentiation|muscle organ development|embryonic digestive tract development|digestive tract morphogenesis|RNA metabolic process|nucleus|leukocyte differentiation|negative regulation of leukocyte cell-cell adhesion|skeletal muscle organ development|positive regulation of T-helper 1 cell differentiation|negative regulation of T-helper 2 cell differentiation|regulation of T-helper 1 cell differentiation|regulation of T cell activation|negative regulation of lymphocyte differentiation|RNA biosynthetic process|sequence-specific DNA binding|negative regulation of T cell activation|regulation of RNA biosynthetic process|T cell differentiation|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|alpha-beta T cell activation|embryonic digestive tract morphogenesis|T-helper 1 type immune response|negative regulation of homotypic cell-cell adhesion|striated muscle tissue development|T-helper 1 cell differentiation|positive regulation of T cell activation|positive regulation of lymphocyte differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of leukocyte cell-cell adhesion|positive regulation of T cell differentiation|alpha-beta T cell differentiation|skeletal muscle tissue development|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|negative regulation of T cell differentiation|negative regulation of alpha-beta T cell activation|CD4-positive, alpha-beta T cell activation|lymphocyte aggregation|positive regulation of T-helper 1 type immune response|positive regulation of alpha-beta T cell differentiation|CD4-positive, alpha-beta T cell differentiation|negative regulation of alpha-beta T cell differentiation|positive regulation of CD4-positive, alpha-beta T cell activation|positive regulation of CD4-positive, alpha-beta T cell differentiation|regulation of CD4-positive, alpha-beta T cell differentiation - - - - 1:220879400-220885059 98 109 84 53 45 36 0.841697483446414 0.850819129586746 0.650464165980629 0.407854420937855 0.317112789663202 0.28977281454583 0.780993593004596 0.338246675048962 1.20723496041756 5.09052132417966e-05 0.000435575877363312 UP ENSG00000224892 RPS4XP16 ribosomal protein S4X pseudogene 16 [Source:HGNC Symbol;Acc:HGNC:36365] - - - - - - 13:51454164-51461315 69 70 49 30 24 23 2.29147782006785 2.11272823734031 1.46714761751566 0.892657962438026 0.65396068006344 0.715860889173109 1.95711789164127 0.754159843891525 1.37578842306204 5.08923289460491e-05 0.000435575877363312 UP ENSG00000180834 MAP6D1 MAP6 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25753] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0005874|GO:0031982|GO:0051128|GO:0043231|GO:0005737|GO:0032886|GO:0032403|GO:0005516|GO:0008092|GO:0044249|GO:0007017|GO:0019538|GO:0005794|GO:0006996|GO:0015631|GO:0005798|GO:0034645|GO:0043412|GO:0007010|GO:0031410|GO:0070507|GO:0005801|GO:0008017|GO:0016023|GO:0036211|GO:0042157|GO:0043242|GO:0031988|GO:0043244|GO:0033043|GO:0044267|GO:0009059|GO:0000226|GO:0005856|GO:0043241|GO:0031110|GO:0051494|GO:0051493|GO:0015630|GO:0031109|GO:0042158|GO:1901879|GO:0006464|GO:0007019|GO:0031365|GO:0007026|GO:0043624|GO:0031111|GO:0018193|GO:0006497|GO:0018345|GO:0051261|GO:0018009 cell|cellular process|metabolic process|binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|microtubule|vesicle|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|regulation of microtubule-based process|protein complex binding|calmodulin binding|cytoskeletal protein binding|cellular biosynthetic process|microtubule-based process|protein metabolic process|Golgi apparatus|organelle organization|tubulin binding|Golgi-associated vesicle|cellular macromolecule biosynthetic process|macromolecule modification|cytoskeleton organization|cytoplasmic vesicle|regulation of microtubule cytoskeleton organization|cis-Golgi network|microtubule binding|cytoplasmic, membrane-bounded vesicle|protein modification process|lipoprotein metabolic process|negative regulation of protein complex disassembly|membrane-bounded vesicle|regulation of protein complex disassembly|regulation of organelle organization|cellular protein metabolic process|macromolecule biosynthetic process|microtubule cytoskeleton organization|cytoskeleton|protein complex disassembly|regulation of microtubule polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|microtubule cytoskeleton|microtubule polymerization or depolymerization|lipoprotein biosynthetic process|regulation of protein depolymerization|cellular protein modification process|microtubule depolymerization|N-terminal protein amino acid modification|negative regulation of microtubule depolymerization|cellular protein complex disassembly|negative regulation of microtubule polymerization or depolymerization|peptidyl-amino acid modification|protein lipidation|protein palmitoylation|protein depolymerization|N-terminal peptidyl-L-cysteine N-palmitoylation - - - - 3:183815876-183825594 99 106 193 58 71 54 1.84676184233607 1.79706065938327 3.24600835120619 0.969399054528566 1.08667916578905 0.94405415371814 2.29661028430851 1.00004412467859 1.19944240706772 5.10374120532752e-05 0.000436581919609879 UP ENSG00000228407 RP4-800M22.1 - - - - - - - 1:52160261-52160600 7 5 8 0 0 1 1.45637667974001 0.945490985450639 1.50066004698149 0 0 0.194958074640347 1.30084257072405 0.0649860248801157 4.32317306329318 5.18917885892805e-05 0.000443255352373213 UP ENSG00000186350 RXRA retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0042995|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0003006|GO:0000989|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0009605|GO:0004879|GO:0009893|GO:0032504|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0016032|GO:0098531|GO:0007507|GO:0001893|GO:0042127|GO:0044255|GO:0048565|GO:0001890|GO:0003712|GO:0006725|GO:0003707|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:1901360|GO:0010941|GO:0031641|GO:0006082|GO:0009991|GO:0060742|GO:0007275|GO:0003676|GO:0048513|GO:0005102|GO:0034641|GO:0044281|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0007566|GO:0060687|GO:0022607|GO:0010942|GO:0035265|GO:0061061|GO:0055017|GO:0043231|GO:0060740|GO:0048608|GO:0006413|GO:0043169|GO:0019899|GO:0010243|GO:0000981|GO:0001763|GO:0009611|GO:0007423|GO:0043235|GO:0060512|GO:0009887|GO:0005667|GO:0032403|GO:0043005|GO:0048729|GO:0046983|GO:0009890|GO:0003708|GO:0003682|GO:0060135|GO:0019904|GO:0006139|GO:0000790|GO:0007154|GO:0007565|GO:0006629|GO:0007165|GO:0008134|GO:0009725|GO:0008219|GO:0008285|GO:0060688|GO:0030030|GO:0048869|GO:0010035|GO:0044249|GO:0030850|GO:0010876|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0048732|GO:0007568|GO:0051701|GO:0003205|GO:0007584|GO:0003713|GO:0019048|GO:0032268|GO:0031175|GO:0042809|GO:0003677|GO:0010468|GO:0034645|GO:0006518|GO:0055123|GO:0046872|GO:0001654|GO:0002009|GO:0033993|GO:0003208|GO:0031102|GO:0044798|GO:0030424|GO:0061458|GO:0072358|GO:0001655|GO:0010629|GO:0051427|GO:0042692|GO:0048678|GO:0046982|GO:1901522|GO:0051252|GO:0006066|GO:0035051|GO:0042974|GO:0048738|GO:0006446|GO:0003007|GO:1901652|GO:0061138|GO:0022612|GO:0009790|GO:0001889|GO:0071417|GO:0010628|GO:0060442|GO:0060528|GO:0004886|GO:0060537|GO:2000027|GO:0006811|GO:0006954|GO:0033273|GO:0031981|GO:0003231|GO:0043434|GO:0006869|GO:0051247|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0008202|GO:0060038|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0043603|GO:0032526|GO:0044267|GO:0045948|GO:0010467|GO:0007399|GO:0071310|GO:0060415|GO:0010269|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0009755|GO:0008206|GO:0007494|GO:0043068|GO:0007517|GO:0016070|GO:0072359|GO:0031667|GO:0032870|GO:0010557|GO:0005634|GO:0043067|GO:0048545|GO:0097305|GO:0051960|GO:0030522|GO:0048644|GO:0008366|GO:0006766|GO:0031490|GO:0048666|GO:0030182|GO:0043401|GO:0000975|GO:0045893|GO:0033280|GO:0043043|GO:0006820|GO:0015711|GO:0009792|GO:0043065|GO:0043566|GO:0051259|GO:0030855|GO:1901653|GO:0045892|GO:0043010|GO:0032774|GO:0015721|GO:0043565|GO:0035357|GO:2001141|GO:0035257|GO:0045727|GO:0010608|GO:1902679|GO:0071383|GO:0071407|GO:0003690|GO:0048384|GO:0061564|GO:0046942|GO:0006412|GO:0045471|GO:0006417|GO:0071375|GO:0016125|GO:0051146|GO:0042981|GO:0046914|GO:0003229|GO:0019752|GO:0032868|GO:0090575|GO:0042552|GO:0055008|GO:0014706|GO:0022008|GO:0055007|GO:0031103|GO:0055010|GO:0033189|GO:0071396|GO:0031960|GO:0006351|GO:0006915|GO:0006355|GO:0045994|GO:0051384|GO:0015718|GO:0045944|GO:0006366|GO:1903507|GO:0006352|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0032869|GO:0008203|GO:0043009|GO:0032787|GO:0055012|GO:0000122|GO:0051260|GO:0051262|GO:0008270|GO:0006367|GO:0002067|GO:0000976|GO:0070644|GO:0001012|GO:0051289|GO:0044323|GO:0001701|GO:0000977 developmental process|growth|macromolecular complex|signal transducer activity|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|cell projection|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|developmental process involved in reproduction|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|response to external stimulus|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|viral process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|heart development|maternal placenta development|regulation of cell proliferation|cellular lipid metabolic process|digestive tract development|placenta development|transcription cofactor activity|cellular aromatic compound metabolic process|steroid hormone receptor activity|tissue development|cell development|transport|tube development|organic cyclic compound metabolic process|regulation of cell death|regulation of myelination|organic acid metabolic process|response to extracellular stimulus|epithelial cell differentiation involved in prostate gland development|multicellular organism development|nucleic acid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|embryo implantation|regulation of branching involved in prostate gland morphogenesis|cellular component assembly|positive regulation of cell death|organ growth|muscle structure development|cardiac muscle tissue growth|intracellular membrane-bounded organelle|prostate gland epithelium morphogenesis|reproductive structure development|translational initiation|cation binding|enzyme binding|response to organonitrogen compound|RNA polymerase II transcription factor activity, sequence-specific DNA binding|morphogenesis of a branching structure|response to wounding|sensory organ development|receptor complex|prostate gland morphogenesis|organ morphogenesis|transcription factor complex|protein complex binding|neuron projection|tissue morphogenesis|protein dimerization activity|negative regulation of biosynthetic process|retinoic acid receptor activity|chromatin binding|maternal process involved in female pregnancy|protein domain specific binding|nucleobase-containing compound metabolic process|nuclear chromatin|cell communication|female pregnancy|lipid metabolic process|signal transduction|transcription factor binding|response to hormone|cell death|negative regulation of cell proliferation|regulation of morphogenesis of a branching structure|cell projection organization|cellular developmental process|response to inorganic substance|cellular biosynthetic process|prostate gland development|lipid localization|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|aging|interaction with host|cardiac chamber development|response to nutrient|transcription coactivator activity|modulation by virus of host morphology or physiology|regulation of cellular protein metabolic process|neuron projection development|vitamin D receptor binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|digestive system development|metal ion binding|eye development|morphogenesis of an epithelium|response to lipid|cardiac ventricle morphogenesis|neuron projection regeneration|nuclear transcription factor complex|axon|reproductive system development|cardiovascular system development|urogenital system development|negative regulation of gene expression|hormone receptor binding|muscle cell differentiation|response to axon injury|protein heterodimerization activity|positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus|regulation of RNA metabolic process|alcohol metabolic process|cardiocyte differentiation|retinoic acid receptor binding|cardiac muscle tissue development|regulation of translational initiation|heart morphogenesis|response to peptide|morphogenesis of a branching epithelium|gland morphogenesis|embryo development|liver development|cellular response to organonitrogen compound|positive regulation of gene expression|branching involved in prostate gland morphogenesis|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development|9-cis retinoic acid receptor activity|muscle tissue development|regulation of organ morphogenesis|ion transport|inflammatory response|response to vitamin|nuclear lumen|cardiac ventricle development|response to peptide hormone|lipid transport|positive regulation of protein metabolic process|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|steroid metabolic process|cardiac muscle cell proliferation|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|cellular amide metabolic process|response to retinoic acid|cellular protein metabolic process|positive regulation of translational initiation|gene expression|nervous system development|cellular response to organic substance|muscle tissue morphogenesis|response to selenium ion|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|bile acid metabolic process|midgut development|positive regulation of programmed cell death|muscle organ development|RNA metabolic process|circulatory system development|response to nutrient levels|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|response to steroid hormone|response to alcohol|regulation of nervous system development|intracellular receptor signaling pathway|muscle organ morphogenesis|axon ensheathment|vitamin metabolic process|chromatin DNA binding|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|regulatory region DNA binding|positive regulation of transcription, DNA-templated|response to vitamin D|peptide biosynthetic process|anion transport|organic anion transport|embryo development ending in birth or egg hatching|positive regulation of apoptotic process|structure-specific DNA binding|protein oligomerization|epithelial cell differentiation|cellular response to peptide|negative regulation of transcription, DNA-templated|camera-type eye development|RNA biosynthetic process|bile acid and bile salt transport|sequence-specific DNA binding|peroxisome proliferator activated receptor signaling pathway|regulation of RNA biosynthetic process|nuclear hormone receptor binding|positive regulation of translation|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|retinoic acid receptor signaling pathway|axon development|carboxylic acid transport|translation|response to ethanol|regulation of translation|cellular response to peptide hormone stimulus|sterol metabolic process|striated muscle cell differentiation|regulation of apoptotic process|transition metal ion binding|ventricular cardiac muscle tissue development|carboxylic acid metabolic process|response to insulin|RNA polymerase II transcription factor complex|myelination|cardiac muscle tissue morphogenesis|striated muscle tissue development|neurogenesis|cardiac muscle cell differentiation|axon regeneration|ventricular cardiac muscle tissue morphogenesis|response to vitamin A|cellular response to lipid|response to corticosteroid|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of translational initiation by iron|response to glucocorticoid|monocarboxylic acid transport|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|cellular response to insulin stimulus|cholesterol metabolic process|chordate embryonic development|monocarboxylic acid metabolic process|ventricular cardiac muscle cell differentiation|negative regulation of transcription from RNA polymerase II promoter|protein homooligomerization|protein tetramerization|zinc ion binding|transcription initiation from RNA polymerase II promoter|glandular epithelial cell differentiation|transcription regulatory region sequence-specific DNA binding|vitamin D response element binding|RNA polymerase II regulatory region DNA binding|protein homotetramerization|retinoic acid-responsive element binding|in utero embryonic development|RNA polymerase II regulatory region sequence-specific DNA binding K08524 retinoid X receptor alpha[-] hsa05200|hsa04151|hsa05202|hsa04932|hsa05160|hsa04919|hsa05222|hsa04976|hsa04920|hsa03320|hsa05223|hsa05216 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|Bile secretion - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Thyroid cancer - Homo sapiens (human) 9:134317098-134440585 346 916 1207 2601 2772 1468 2.10663962955727 5.06862020603748 6.62576516470975 14.189021467123 13.84763400343 8.37662881841192 4.60034166676817 12.137761429655 -1.39968945049171 5.29065351541206e-05 0.000450762471601346 DOWN ENSG00000204410 MSH5 mutS homolog 5 [Source:HGNC Symbol;Acc:HGNC:7328] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0007049|GO:0007131|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0033554|GO:0022607|GO:0043231|GO:0070192|GO:0006139|GO:0007126|GO:0007059|GO:0000166|GO:0006996|GO:0051276|GO:0003677|GO:0035639|GO:0001883|GO:0007129|GO:0032549|GO:0007127|GO:0031981|GO:0045132|GO:0006298|GO:0006259|GO:0005694|GO:0000228|GO:0017076|GO:0005634|GO:0051026|GO:0006974|GO:0000793|GO:0005524|GO:0030554|GO:0003690|GO:0000794|GO:0045143|GO:0006310|GO:0000795|GO:0030983 reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|cell cycle|reciprocal meiotic recombination|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|cellular response to stress|cellular component assembly|intracellular membrane-bounded organelle|chromosome organization involved in meiotic cell cycle|nucleobase-containing compound metabolic process|meiotic nuclear division|chromosome segregation|nucleotide binding|organelle organization|chromosome organization|DNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|synapsis|ribonucleoside binding|meiosis I|nuclear lumen|meiotic chromosome segregation|mismatch repair|DNA metabolic process|chromosome|nuclear chromosome|purine nucleotide binding|nucleus|chiasma assembly|cellular response to DNA damage stimulus|condensed chromosome|ATP binding|adenyl nucleotide binding|double-stranded DNA binding|condensed nuclear chromosome|homologous chromosome segregation|DNA recombination|synaptonemal complex|mismatched DNA binding - - - - 6:31739948-31762834 62 93 148 203 252 386 0.470364616648748 0.641221527028242 1.01232139662148 1.37986875920304 1.56859696741989 2.74448106888864 0.70796918009949 1.89764893183719 -1.42245465390436 5.2894352448459e-05 0.000450762471601346 DOWN ENSG00000213033 AURKAPS1 aurora kinase A pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:18611] - - - - - - 1:220266706-220267917 64 26 42 15 16 4 3.73526964647628 1.37910053965001 2.21007544183847 0.784390041251236 0.766175570880451 0.218764836230093 2.44148187598825 0.589776816120593 2.04951605147324 5.3158974093986e-05 0.000452267886178928 UP ENSG00000280376 RP11-93O14.3 - - - - - - - 16:46673443-46673927 6 16 4 0 1 0 0.875054386987609 2.12081821291776 0.526004552550214 0 0.119717995019283 0 1.17395905081853 0.039905998339761 4.87863265932784 5.315875567374e-05 0.000452267886178928 UP ENSG00000179979 CRIPAK cysteine-rich PAK1 inhibitor [Source:HGNC Symbol;Acc:HGNC:26619] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0019222|GO:0051128|GO:0043231|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0044092|GO:0007165|GO:0005783|GO:0009968|GO:0009725|GO:0050790|GO:0043086|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0032268|GO:0033993|GO:0043412|GO:0007010|GO:0036211|GO:0032269|GO:0033143|GO:0033144|GO:0014070|GO:0006796|GO:0033043|GO:0044267|GO:0051174|GO:0071310|GO:0051246|GO:0009755|GO:0032870|GO:0005634|GO:0048545|GO:0030522|GO:0043401|GO:0016310|GO:0043627|GO:0071383|GO:0071407|GO:0030518|GO:0051493|GO:0033673|GO:0006464|GO:0033147|GO:0071396|GO:0043549|GO:0033146|GO:0030520|GO:0045859|GO:0006469|GO:0006468|GO:0042325|GO:0001932|GO:0042326|GO:0001933 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|intracellular|protein binding|plasma membrane|endomembrane system|regulation of metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|negative regulation of molecular function|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|response to hormone|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|response to lipid|macromolecule modification|cytoskeleton organization|protein modification process|negative regulation of cellular protein metabolic process|regulation of intracellular steroid hormone receptor signaling pathway|negative regulation of intracellular steroid hormone receptor signaling pathway|response to organic cyclic compound|phosphate-containing compound metabolic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of protein metabolic process|hormone-mediated signaling pathway|cellular response to hormone stimulus|nucleus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|phosphorylation|response to estrogen|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|regulation of cytoskeleton organization|negative regulation of kinase activity|cellular protein modification process|negative regulation of intracellular estrogen receptor signaling pathway|cellular response to lipid|regulation of kinase activity|regulation of intracellular estrogen receptor signaling pathway|intracellular estrogen receptor signaling pathway|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation - - - - 4:1391552-1395989 47 63 91 140 160 235 0.749130939823344 0.912602626327005 1.30771425435254 1.9993237435549 2.09240785047769 3.51039311238734 0.98981594016763 2.53404156880664 -1.35620800994774 5.33762269128341e-05 0.000453882334639819 DOWN ENSG00000279519 RP11-288C18.1 - - - - - - - 2:36839922-36842539 14 27 47 75 91 102 0.378279657075328 0.66302046630739 1.14494588285521 1.81566220396581 2.01737470495328 2.58288473244158 0.728748668745976 2.13864054712022 -1.55320077336202 5.37106980814804e-05 0.000456441554376463 DOWN ENSG00000267194 RP1-193H18.2 - - - - - - - 17:69551358-69553861 1 1 6 11 17 22 0.0282614590345902 0.0256859931058065 0.152822808298834 0.278417459891837 0.394036748998186 0.582467231853436 0.0689234201464102 0.418307146914486 -2.60149644864864 5.37273952668202e-05 0.000456453516874118 DOWN ENSG00000124787 RPP40 ribonuclease P/MRP 40kDa subunit [Source:HGNC Symbol;Acc:HGNC:20992] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0043234|GO:0006725|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0005730|GO:0030677|GO:0031981|GO:0004518|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0090501|GO:0006396|GO:0034660|GO:0005655|GO:0004519|GO:0004540|GO:0090305|GO:0006399|GO:0090502|GO:0004521|GO:0008033|GO:0004526|GO:0016891 macromolecular complex|cell|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|nucleolus|ribonuclease P complex|nuclear lumen|nuclease activity|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA phosphodiester bond hydrolysis|RNA processing|ncRNA metabolic process|nucleolar ribonuclease P complex|endonuclease activity|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|tRNA metabolic process|RNA phosphodiester bond hydrolysis, endonucleolytic|endoribonuclease activity|tRNA processing|ribonuclease P activity|endoribonuclease activity, producing 5'-phosphomonoesters K14530 ribonucleases P/MRP protein subunit RPP40[3.1.26.5] hsa03013|hsa03008 RNA transport - Homo sapiens (human)|Ribosome biogenesis in eukaryotes - Homo sapiens (human) 6:4994732-5004063 563 676 353 256 329 175 11.8244709370284 12.9032889117478 6.68440765850151 4.81737565422841 5.66940280394995 3.44462182092016 10.4707225024259 4.64380009303284 1.17298322146003 5.39733079993992e-05 0.000458281893348709 UP ENSG00000227766 HCG4P5 HLA complex group 4 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:22925] - - - - - - 6:29942075-29943067 98 143 146 64 60 70 6.98108809029674 9.25792006240162 9.37696736969307 4.08484021189661 3.5068303121741 4.67327926530059 8.53865850746381 4.0883165964571 1.06250250662713 5.39642300013658e-05 0.000458281893348709 UP ENSG00000144214 LYG1 lysozyme G-like 1 [Source:HGNC Symbol;Acc:HGNC:27014] GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0016787|GO:0016798|GO:0016998|GO:0004553|GO:0003796|GO:0030203|GO:0006027|GO:0009253 cellular process|extracellular region|metabolic process|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|hydrolase activity|hydrolase activity, acting on glycosyl bonds|cell wall macromolecule catabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|lysozyme activity|glycosaminoglycan metabolic process|glycosaminoglycan catabolic process|peptidoglycan catabolic process - - - - 2:99284238-99304742 92 93 43 24 27 32 4.52245941346468 4.15479466157841 1.9057373963364 1.05703707043224 1.088957393044 1.47423621896358 3.52766382379316 1.20674356081327 1.54759395418323 5.47119666091215e-05 0.000464421680736057 UP ENSG00000083799 CYLD cylindromatosis (turban tumor syndrome) [Source:HGNC Symbol;Acc:HGNC:2584] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0030496|GO:0051716|GO:0019898|GO:0042995|GO:0002683|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:1903828|GO:0023057|GO:0016787|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0048646|GO:0019222|GO:0060341|GO:0001818|GO:0002757|GO:0051726|GO:0007049|GO:1903706|GO:1900181|GO:0016337|GO:0009898|GO:0045087|GO:0045595|GO:0006725|GO:1902115|GO:0006810|GO:1901360|GO:0010941|GO:0070064|GO:0007275|GO:0045596|GO:0048513|GO:0070489|GO:0034641|GO:0005874|GO:0006952|GO:0030155|GO:0046483|GO:0051128|GO:0022607|GO:0010942|GO:0001817|GO:0098609|GO:0043169|GO:0008233|GO:0019899|GO:0005737|GO:0002218|GO:0001816|GO:0032886|GO:0032880|GO:0031234|GO:0001775|GO:0098562|GO:0009966|GO:0045184|GO:0009890|GO:0019897|GO:0036064|GO:0032387|GO:0010646|GO:0006139|GO:0007162|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0060491|GO:0007165|GO:0050778|GO:0009968|GO:0051649|GO:0097542|GO:0008219|GO:0002695|GO:0090317|GO:0030030|GO:0048869|GO:0009967|GO:0044249|GO:0007017|GO:0019538|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:0006996|GO:0051090|GO:0051249|GO:2001235|GO:0030111|GO:0000902|GO:0005829|GO:0005813|GO:0031344|GO:0010468|GO:0036459|GO:0034645|GO:0030178|GO:0042308|GO:0032479|GO:0046872|GO:0007166|GO:0001959|GO:0061578|GO:0043412|GO:0072594|GO:0007010|GO:0030097|GO:0002758|GO:0034097|GO:0030163|GO:0030098|GO:0010629|GO:0070507|GO:0051252|GO:0005815|GO:0032386|GO:0034109|GO:0051223|GO:0015031|GO:0044265|GO:1902017|GO:0036211|GO:0044782|GO:0000278|GO:0070201|GO:0046907|GO:0042886|GO:0051250|GO:0022408|GO:0022407|GO:0007346|GO:0030031|GO:0032480|GO:0007159|GO:0032606|GO:0048471|GO:0006508|GO:0022604|GO:0043433|GO:0002764|GO:0006461|GO:0034613|GO:0070925|GO:0019900|GO:0042110|GO:0012501|GO:0042384|GO:0035556|GO:0033043|GO:0044267|GO:0010467|GO:0017038|GO:0032990|GO:0031503|GO:0071310|GO:1902532|GO:0009059|GO:0030154|GO:0005881|GO:0048858|GO:0043068|GO:1903827|GO:1902531|GO:0016070|GO:0000226|GO:0005856|GO:0005819|GO:0043067|GO:0045089|GO:0006606|GO:0030522|GO:0097190|GO:0045088|GO:0060271|GO:0002521|GO:1903038|GO:0016055|GO:1904589|GO:0044257|GO:0097193|GO:0043124|GO:0019221|GO:2001242|GO:0033365|GO:0033157|GO:0050863|GO:0043122|GO:0090090|GO:0043065|GO:0010803|GO:0051169|GO:0060828|GO:0045892|GO:0045620|GO:0032774|GO:0050868|GO:2001141|GO:0030217|GO:2001236|GO:0015833|GO:0006605|GO:0045619|GO:1902679|GO:2001238|GO:0035872|GO:0002221|GO:0070486|GO:0016482|GO:0006886|GO:0051493|GO:0051603|GO:0015630|GO:0007249|GO:0097300|GO:0070646|GO:0042981|GO:0071345|GO:0042992|GO:0032088|GO:0046914|GO:0034612|GO:0042306|GO:0034111|GO:0097343|GO:0042345|GO:0004843|GO:1900180|GO:0019901|GO:0008234|GO:0006464|GO:0097191|GO:0042991|GO:0006351|GO:0006915|GO:0006355|GO:1903533|GO:0006913|GO:1903507|GO:0019941|GO:0071356|GO:0045580|GO:1903506|GO:0060070|GO:0016579|GO:0045581|GO:0070423|GO:0070266|GO:0033209|GO:0042990|GO:0042347|GO:0071593|GO:1901026|GO:0008270|GO:0034504|GO:0046822|GO:0006511|GO:0051170|GO:0070536 developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|midbody|cellular response to stimulus|extrinsic component of membrane|cell projection|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|negative regulation of cellular protein localization|negative regulation of signaling|hydrolase activity|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cellular localization|negative regulation of cytokine production|immune response-activating signal transduction|regulation of cell cycle|cell cycle|regulation of hemopoiesis|negative regulation of protein localization to nucleus|single organismal cell-cell adhesion|cytoplasmic side of plasma membrane|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|regulation of organelle assembly|transport|organic cyclic compound metabolic process|regulation of cell death|proline-rich region binding|multicellular organism development|negative regulation of cell differentiation|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|microtubule|defense response|regulation of cell adhesion|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of cell death|regulation of cytokine production|cell-cell adhesion|cation binding|peptidase activity|enzyme binding|cytoplasm|activation of innate immune response|cytokine production|regulation of microtubule-based process|regulation of protein localization|extrinsic component of cytoplasmic side of plasma membrane|cell activation|cytoplasmic side of membrane|regulation of signal transduction|establishment of protein localization|negative regulation of biosynthetic process|extrinsic component of plasma membrane|ciliary basal body|negative regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|negative regulation of cell adhesion|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|regulation of cell projection assembly|signal transduction|positive regulation of immune response|negative regulation of signal transduction|establishment of localization in cell|ciliary tip|cell death|negative regulation of leukocyte activation|negative regulation of intracellular protein transport|cell projection organization|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|microtubule-based process|protein metabolic process|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|regulation of lymphocyte activation|positive regulation of apoptotic signaling pathway|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|centrosome|regulation of cell projection organization|regulation of gene expression|thiol-dependent ubiquitinyl hydrolase activity|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|negative regulation of protein import into nucleus|regulation of type I interferon production|metal ion binding|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|Lys63-specific deubiquitinase activity|macromolecule modification|establishment of protein localization to organelle|cytoskeleton organization|hemopoiesis|innate immune response-activating signal transduction|response to cytokine|protein catabolic process|lymphocyte differentiation|negative regulation of gene expression|regulation of microtubule cytoskeleton organization|regulation of RNA metabolic process|microtubule organizing center|regulation of intracellular transport|homotypic cell-cell adhesion|regulation of protein transport|protein transport|cellular macromolecule catabolic process|regulation of cilium assembly|protein modification process|cilium organization|mitotic cell cycle|regulation of establishment of protein localization|intracellular transport|amide transport|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of mitotic cell cycle|cell projection assembly|negative regulation of type I interferon production|leukocyte cell-cell adhesion|type I interferon production|perinuclear region of cytoplasm|proteolysis|regulation of cell morphogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|immune response-regulating signaling pathway|protein complex assembly|cellular protein localization|organelle assembly|kinase binding|T cell activation|programmed cell death|cilium assembly|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|gene expression|protein import|cell part morphogenesis|protein complex localization|cellular response to organic substance|negative regulation of intracellular signal transduction|macromolecule biosynthetic process|cell differentiation|cytoplasmic microtubule|cell projection morphogenesis|positive regulation of programmed cell death|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|microtubule cytoskeleton organization|cytoskeleton|spindle|regulation of programmed cell death|positive regulation of innate immune response|protein import into nucleus|intracellular receptor signaling pathway|apoptotic signaling pathway|regulation of innate immune response|cilium morphogenesis|leukocyte differentiation|negative regulation of leukocyte cell-cell adhesion|Wnt signaling pathway|regulation of protein import|cellular protein catabolic process|intrinsic apoptotic signaling pathway|negative regulation of I-kappaB kinase/NF-kappaB signaling|cytokine-mediated signaling pathway|regulation of intrinsic apoptotic signaling pathway|protein localization to organelle|regulation of intracellular protein transport|regulation of T cell activation|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of canonical Wnt signaling pathway|positive regulation of apoptotic process|regulation of tumor necrosis factor-mediated signaling pathway|nuclear transport|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|negative regulation of lymphocyte differentiation|RNA biosynthetic process|negative regulation of T cell activation|regulation of RNA biosynthetic process|T cell differentiation|regulation of extrinsic apoptotic signaling pathway|peptide transport|protein targeting|regulation of lymphocyte differentiation|negative regulation of RNA biosynthetic process|positive regulation of extrinsic apoptotic signaling pathway|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|pattern recognition receptor signaling pathway|leukocyte aggregation|cytosolic transport|intracellular protein transport|regulation of cytoskeleton organization|proteolysis involved in cellular protein catabolic process|microtubule cytoskeleton|I-kappaB kinase/NF-kappaB signaling|programmed necrotic cell death|protein modification by small protein removal|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of transcription factor import into nucleus|negative regulation of NF-kappaB transcription factor activity|transition metal ion binding|response to tumor necrosis factor|regulation of protein import into nucleus|negative regulation of homotypic cell-cell adhesion|ripoptosome assembly|regulation of NF-kappaB import into nucleus|thiol-dependent ubiquitin-specific protease activity|regulation of protein localization to nucleus|protein kinase binding|cysteine-type peptidase activity|cellular protein modification process|extrinsic apoptotic signaling pathway|transcription factor import into nucleus|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of protein targeting|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|modification-dependent protein catabolic process|cellular response to tumor necrosis factor|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|protein deubiquitination|negative regulation of T cell differentiation|nucleotide-binding oligomerization domain containing signaling pathway|necroptotic process|tumor necrosis factor-mediated signaling pathway|regulation of transcription factor import into nucleus|negative regulation of NF-kappaB import into nucleus|lymphocyte aggregation|ripoptosome assembly involved in necroptotic process|zinc ion binding|protein localization to nucleus|regulation of nucleocytoplasmic transport|ubiquitin-dependent protein catabolic process|nuclear import|protein K63-linked deubiquitination K08601 ubiquitin thioesterase CYLD[3.4.19.12] hsa04380|hsa04622 Osteoclast differentiation - Homo sapiens (human)|RIG-I-like receptor signaling pathway - Homo sapiens (human) 16:50742050-50801935 184 205 342 514 482 614 0.608830196042775 0.616471482405609 1.02028065282281 1.5238407816591 1.30855956848535 1.9040380235732 0.748527443757065 1.57881279123922 -1.07671299598114 5.47834220712605e-05 0.000464896043921379 DOWN ENSG00000266794 RN7SL7P RNA, 7SL, cytoplasmic 7, pseudogene [Source:HGNC Symbol;Acc:HGNC:10042] - - - - - - 7:92971002-92971299 1 1 3 11 9 20 0.237472125579241 0.215831297774964 0.6419489322593 2.33945409251396 1.752807257931 4.44918101025223 0.365084118537835 2.84714745356573 -2.96321639527067 5.49358904037985e-05 0.000465792693017608 DOWN ENSG00000235865 GSN-AS1 GSN antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:23372] - - - - - - 9:121280768-121285530 3 4 3 16 18 18 0.0445588535206685 0.0539889162956704 0.0401639264776971 0.212897233570714 0.219330910293277 0.250532112177142 0.046237232098012 0.227586752013711 -2.29928963838394 5.53604852811459e-05 0.000469259491079878 DOWN ENSG00000257261 RP11-96H19.1 - - - - - - - 12:46383679-46876159 3 3 6 19 27 15 0.0953003229990768 0.0866153259519885 0.171831303089484 0.540729295206034 0.703641530574907 0.446532202140357 0.117915650680183 0.563634342640433 -2.25700430205056 5.55766382950932e-05 0.000470824335885844 DOWN ENSG00000165714 BORCS5 BLOC-1 related complex subunit 5 [Source:HGNC Symbol;Acc:HGNC:17950] GO:0016020|GO:0005488|GO:0005515 membrane|binding|protein binding - - - - 12:12357079-12469694 55 72 119 211 195 195 0.6572920450281 0.782004688240075 1.28221343414843 2.25931390664838 1.91205392560202 2.18404160059373 0.907170055805535 2.11846981094804 -1.22357764467671 5.58027854272395e-05 0.000472338065252284 DOWN ENSG00000133424 LARGE like-glycosyltransferase [Source:HGNC Symbol;Acc:HGNC:6511] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0048589|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0048856|GO:0031090|GO:0006486|GO:0044255|GO:0031228|GO:0009888|GO:0007275|GO:0048513|GO:0042246|GO:0061061|GO:0043231|GO:0043169|GO:0005737|GO:0009611|GO:0005975|GO:0042592|GO:0019725|GO:0006629|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0005794|GO:0034645|GO:0006665|GO:0046872|GO:0043412|GO:0008194|GO:0006643|GO:0046716|GO:0030173|GO:0006493|GO:0009100|GO:0036211|GO:0042060|GO:0006040|GO:0016758|GO:0070085|GO:0043403|GO:0035268|GO:1901137|GO:0044267|GO:0008610|GO:0016763|GO:0000139|GO:0009059|GO:0007517|GO:0097502|GO:0060538|GO:0009101|GO:0043413|GO:0006687|GO:0008375|GO:0009247|GO:0015020|GO:0006664|GO:0046914|GO:0042285|GO:0030148|GO:0006464|GO:0035269|GO:0006688|GO:0030145|GO:0006044 developmental process|growth|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|developmental growth|intracellular|protein binding|endomembrane system|transferase activity|anatomical structure development|organelle membrane|protein glycosylation|cellular lipid metabolic process|intrinsic component of Golgi membrane|tissue development|multicellular organism development|animal organ development|tissue regeneration|muscle structure development|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to wounding|carbohydrate metabolic process|homeostatic process|cellular homeostasis|lipid metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|Golgi apparatus|cellular macromolecule biosynthetic process|sphingolipid metabolic process|metal ion binding|macromolecule modification|UDP-glycosyltransferase activity|membrane lipid metabolic process|muscle cell cellular homeostasis|integral component of Golgi membrane|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|wound healing|amino sugar metabolic process|transferase activity, transferring hexosyl groups|glycosylation|skeletal muscle tissue regeneration|protein mannosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|lipid biosynthetic process|transferase activity, transferring pentosyl groups|Golgi membrane|macromolecule biosynthetic process|muscle organ development|mannosylation|skeletal muscle organ development|glycoprotein biosynthetic process|macromolecule glycosylation|glycosphingolipid metabolic process|acetylglucosaminyltransferase activity|glycolipid biosynthetic process|glucuronosyltransferase activity|glycolipid metabolic process|transition metal ion binding|xylosyltransferase activity|sphingolipid biosynthetic process|cellular protein modification process|protein O-linked mannosylation|glycosphingolipid biosynthetic process|manganese ion binding|N-acetylglucosamine metabolic process - - - - 22:33162226-33922841 1 0 1 8 7 11 0.00404473556370678 0 0.00364338579217218 0.0289807282152879 0.0232206349476262 0.041678881796142 0.00256270711862632 0.031293414986352 -3.61011859211346 5.60341590824292e-05 0.000474027709052661 DOWN ENSG00000165240 ATP7A ATPase, Cu++ transporting, alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:869] GO:0032502|GO:0016530|GO:0005215|GO:0002376|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0016531|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0022857|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0044297|GO:0009653|GO:0016043|GO:0043473|GO:0007155|GO:0043227|GO:0071944|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0030234|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0012505|GO:0007626|GO:0048856|GO:0048646|GO:0019222|GO:0019430|GO:0005903|GO:0010273|GO:0098869|GO:0016337|GO:0002286|GO:0048286|GO:0006725|GO:0021692|GO:0009888|GO:0048468|GO:0043025|GO:0016323|GO:0006810|GO:0035295|GO:0021697|GO:1901360|GO:0001568|GO:0006082|GO:0007275|GO:0030324|GO:0048513|GO:0070489|GO:0034641|GO:0043168|GO:0021587|GO:0008047|GO:0043062|GO:0044281|GO:0030902|GO:0030900|GO:0031069|GO:0001882|GO:0031982|GO:0019637|GO:0046483|GO:0033554|GO:0032767|GO:0016817|GO:0007420|GO:0022607|GO:0098609|GO:0030141|GO:0005887|GO:0043231|GO:0043169|GO:0030133|GO:0001942|GO:0005737|GO:0006520|GO:0060322|GO:0042592|GO:0072593|GO:0001775|GO:0043005|GO:0048729|GO:0002263|GO:0048771|GO:0019725|GO:0036477|GO:0022891|GO:0030323|GO:0006979|GO:0006139|GO:0031226|GO:0043085|GO:0021696|GO:0055086|GO:0021695|GO:0046649|GO:0044092|GO:0055085|GO:0022037|GO:0002366|GO:0005783|GO:0016532|GO:0021694|GO:0050790|GO:0000166|GO:0030030|GO:0021549|GO:0031253|GO:0006091|GO:0043086|GO:0048869|GO:0016021|GO:0010035|GO:0044249|GO:0019538|GO:0021680|GO:0031323|GO:0002292|GO:0048732|GO:0050878|GO:0021575|GO:0005794|GO:0005768|GO:0006996|GO:0009636|GO:0000902|GO:0016820|GO:0005829|GO:0031175|GO:0005798|GO:0030879|GO:0034645|GO:0051216|GO:0005802|GO:0046872|GO:0002009|GO:0035639|GO:0001944|GO:0043412|GO:0007589|GO:0030097|GO:0072358|GO:0042417|GO:0030098|GO:0007417|GO:0031410|GO:0048554|GO:0019693|GO:0007005|GO:0022405|GO:0048878|GO:0060541|GO:0031526|GO:0009308|GO:0042428|GO:0001883|GO:0009790|GO:0010038|GO:0016023|GO:0016818|GO:0009100|GO:0036211|GO:0009116|GO:0006811|GO:0032549|GO:0055082|GO:0015075|GO:0009072|GO:0021533|GO:0005770|GO:0034599|GO:0007159|GO:0048471|GO:0031988|GO:0046688|GO:0085029|GO:0018958|GO:0043588|GO:0007595|GO:0001974|GO:0051353|GO:0021872|GO:0051341|GO:0042110|GO:0060429|GO:0043467|GO:0000302|GO:0010043|GO:0006796|GO:0021702|GO:1901137|GO:0044267|GO:0051174|GO:0000305|GO:0032990|GO:0007399|GO:0030140|GO:0006119|GO:0046903|GO:0017076|GO:0030198|GO:0010039|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0042093|GO:0072359|GO:0006584|GO:0048552|GO:0006801|GO:0034220|GO:0042633|GO:0048553|GO:0048666|GO:0006568|GO:0030182|GO:0002082|GO:0002521|GO:0021953|GO:0009101|GO:0098655|GO:0048251|GO:0009792|GO:0009259|GO:0009117|GO:0005524|GO:0006812|GO:0030217|GO:0030554|GO:0016310|GO:0008544|GO:0070486|GO:0046631|GO:0030135|GO:0042625|GO:0021954|GO:0006576|GO:0030199|GO:0010041|GO:0006163|GO:0048730|GO:0042415|GO:0046914|GO:0050801|GO:0019752|GO:0021879|GO:0034614|GO:0022008|GO:0006464|GO:0042626|GO:0042414|GO:0048812|GO:0016462|GO:0042278|GO:0006873|GO:0008324|GO:0000303|GO:0098773|GO:0051541|GO:0009712|GO:0030136|GO:0021859|GO:0019829|GO:1903578|GO:0071451|GO:0005507|GO:0046632|GO:0048699|GO:0051542|GO:0017111|GO:0042325|GO:0018193|GO:0022890|GO:0043009|GO:0021884|GO:0030001|GO:0035710|GO:0071593|GO:0030003|GO:0016887|GO:0046034|GO:0043682|GO:0021860|GO:0055065|GO:0006875|GO:0035434|GO:0001701|GO:0043367|GO:0018205|GO:0046873|GO:0046915|GO:0042623|GO:0015679|GO:0060003|GO:0004008|GO:0006825|GO:0006878|GO:0005375|GO:0015677|GO:0043492|GO:0055070 developmental process|metallochaperone activity|transporter activity|immune system process|behavior|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|copper chaperone activity|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|transmembrane transporter activity|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cell body|anatomical structure morphogenesis|cellular component organization|pigmentation|cell adhesion|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|intracellular|immune system development|protein binding|plasma membrane|endomembrane system|locomotory behavior|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|removal of superoxide radicals|brush border|detoxification of copper ion|cellular oxidant detoxification|single organismal cell-cell adhesion|T cell activation involved in immune response|lung alveolus development|cellular aromatic compound metabolic process|cerebellar Purkinje cell layer morphogenesis|tissue development|cell development|neuronal cell body|basolateral plasma membrane|transport|tube development|cerebellar cortex formation|organic cyclic compound metabolic process|blood vessel development|organic acid metabolic process|multicellular organism development|lung development|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|anion binding|cerebellum morphogenesis|enzyme activator activity|extracellular structure organization|small molecule metabolic process|hindbrain development|forebrain development|hair follicle morphogenesis|nucleoside binding|vesicle|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|copper-dependent protein binding|hydrolase activity, acting on acid anhydrides|brain development|cellular component assembly|cell-cell adhesion|secretory granule|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|transport vesicle|hair follicle development|cytoplasm|cellular amino acid metabolic process|head development|homeostatic process|reactive oxygen species metabolic process|cell activation|neuron projection|tissue morphogenesis|cell activation involved in immune response|tissue remodeling|cellular homeostasis|somatodendritic compartment|substrate-specific transmembrane transporter activity|respiratory tube development|response to oxidative stress|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|cerebellar cortex morphogenesis|nucleobase-containing small molecule metabolic process|cerebellar cortex development|lymphocyte activation|negative regulation of molecular function|transmembrane transport|metencephalon development|leukocyte activation involved in immune response|endoplasmic reticulum|superoxide dismutase copper chaperone activity|cerebellar Purkinje cell layer formation|regulation of catalytic activity|nucleotide binding|cell projection organization|cerebellum development|cell projection membrane|generation of precursor metabolites and energy|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|response to inorganic substance|cellular biosynthetic process|protein metabolic process|cerebellar Purkinje cell layer development|regulation of cellular metabolic process|T cell differentiation involved in immune response|gland development|regulation of body fluid levels|hindbrain morphogenesis|Golgi apparatus|endosome|organelle organization|response to toxic substance|cell morphogenesis|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|cytosol|neuron projection development|Golgi-associated vesicle|mammary gland development|cellular macromolecule biosynthetic process|cartilage development|trans-Golgi network|metal ion binding|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|vasculature development|macromolecule modification|body fluid secretion|hemopoiesis|cardiovascular system development|dopamine metabolic process|lymphocyte differentiation|central nervous system development|cytoplasmic vesicle|positive regulation of metalloenzyme activity|ribose phosphate metabolic process|mitochondrion organization|hair cycle process|chemical homeostasis|respiratory system development|brush border membrane|amine metabolic process|serotonin metabolic process|purine nucleoside binding|embryo development|response to metal ion|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|glycoprotein metabolic process|protein modification process|nucleoside metabolic process|ion transport|ribonucleoside binding|cellular chemical homeostasis|ion transmembrane transporter activity|aromatic amino acid family metabolic process|cell differentiation in hindbrain|late endosome|cellular response to oxidative stress|leukocyte cell-cell adhesion|perinuclear region of cytoplasm|membrane-bounded vesicle|response to copper ion|extracellular matrix assembly|phenol-containing compound metabolic process|skin development|lactation|blood vessel remodeling|positive regulation of oxidoreductase activity|forebrain generation of neurons|regulation of oxidoreductase activity|T cell activation|epithelium development|regulation of generation of precursor metabolites and energy|response to reactive oxygen species|response to zinc ion|phosphate-containing compound metabolic process|cerebellar Purkinje cell differentiation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|response to oxygen radical|cell part morphogenesis|nervous system development|trans-Golgi network transport vesicle|oxidative phosphorylation|secretion|purine nucleotide binding|extracellular matrix organization|response to iron ion|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|T-helper cell differentiation|circulatory system development|catecholamine metabolic process|regulation of metalloenzyme activity|superoxide metabolic process|ion transmembrane transport|hair cycle|negative regulation of metalloenzyme activity|neuron development|tryptophan metabolic process|neuron differentiation|regulation of oxidative phosphorylation|leukocyte differentiation|central nervous system neuron differentiation|glycoprotein biosynthetic process|cation transmembrane transport|elastic fiber assembly|embryo development ending in birth or egg hatching|ribonucleotide metabolic process|nucleotide metabolic process|ATP binding|cation transport|T cell differentiation|adenyl nucleotide binding|phosphorylation|epidermis development|leukocyte aggregation|alpha-beta T cell activation|coated vesicle|ATPase coupled ion transmembrane transporter activity|central nervous system neuron development|cellular biogenic amine metabolic process|collagen fibril organization|response to iron(III) ion|purine nucleotide metabolic process|epidermis morphogenesis|norepinephrine metabolic process|transition metal ion binding|ion homeostasis|carboxylic acid metabolic process|forebrain neuron differentiation|cellular response to reactive oxygen species|neurogenesis|cellular protein modification process|ATPase activity, coupled to transmembrane movement of substances|epinephrine metabolic process|neuron projection morphogenesis|pyrophosphatase activity|purine nucleoside metabolic process|cellular ion homeostasis|cation transmembrane transporter activity|response to superoxide|skin epidermis development|elastin metabolic process|catechol-containing compound metabolic process|clathrin-coated vesicle|pyramidal neuron differentiation|cation-transporting ATPase activity|regulation of ATP metabolic process|cellular response to superoxide|copper ion binding|alpha-beta T cell differentiation|generation of neurons|elastin biosynthetic process|nucleoside-triphosphatase activity|regulation of phosphorylation|peptidyl-amino acid modification|inorganic cation transmembrane transporter activity|chordate embryonic development|forebrain neuron development|metal ion transport|CD4-positive, alpha-beta T cell activation|lymphocyte aggregation|cellular cation homeostasis|ATPase activity|ATP metabolic process|copper-transporting ATPase activity|pyramidal neuron development|metal ion homeostasis|cellular metal ion homeostasis|copper ion transmembrane transport|in utero embryonic development|CD4-positive, alpha-beta T cell differentiation|peptidyl-lysine modification|metal ion transmembrane transporter activity|transition metal ion transmembrane transporter activity|ATPase activity, coupled|plasma membrane copper ion transport|copper ion export|copper-exporting ATPase activity|copper ion transport|cellular copper ion homeostasis|copper ion transmembrane transporter activity|copper ion import|ATPase activity, coupled to movement of substances|copper ion homeostasis K17686 Cu+-exporting ATPase[3.6.3.54] hsa04978 Mineral absorption - Homo sapiens (human) X:77910656-78050395 215 279 510 634 707 1162 1.08530734131299 1.27996772316551 2.32112601082747 2.86748833727826 2.92820772787501 5.49730228528605 1.56213369176866 3.76433278347977 -1.26887624561635 5.6146631909738e-05 0.000474844631454198 DOWN ENSG00000148680 HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [Source:HGNC Symbol;Acc:HGNC:5302] GO:0004871|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0007623|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0005887|GO:0004888|GO:0003012|GO:0007267|GO:0031226|GO:0007154|GO:0007165|GO:0016021|GO:0003013|GO:0007186|GO:0035150|GO:0006936|GO:0008015|GO:0004930|GO:0004993|GO:0007187|GO:0006939|GO:0007210|GO:0008227|GO:0050880|GO:0042310|GO:0007268 signal transducer activity|signaling|cell|rhythmic process|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|circadian rhythm|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|integral component of plasma membrane|transmembrane signaling receptor activity|muscle system process|cell-cell signaling|intrinsic component of plasma membrane|cell communication|signal transduction|integral component of membrane|circulatory system process|G-protein coupled receptor signaling pathway|regulation of tube size|muscle contraction|blood circulation|G-protein coupled receptor activity|G-protein coupled serotonin receptor activity|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|smooth muscle contraction|serotonin receptor signaling pathway|G-protein coupled amine receptor activity|regulation of blood vessel size|vasoconstriction|synaptic transmission K04163 5-hydroxytryptamine receptor 7[-] hsa04080|hsa04014|hsa04020|hsa04726 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human) 10:90740823-90857698 6 7 5 33 63 12 0.109184815458963 0.115781203810485 0.0820316145630817 0.538068422615765 0.940677659221252 0.204656408871371 0.102332544610843 0.561134163569463 -2.45508071575826 5.62078065973179e-05 0.000475092825072573 DOWN ENSG00000108799 EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit [Source:HGNC Symbol;Acc:HGNC:3526] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0019222|GO:0006725|GO:0021766|GO:1901360|GO:0007275|GO:0016570|GO:0048513|GO:0034641|GO:0030900|GO:0031325|GO:0046483|GO:0007420|GO:0043231|GO:0060322|GO:0031519|GO:0003682|GO:0006139|GO:0021543|GO:0021537|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0051276|GO:0008168|GO:0010468|GO:0034645|GO:0043412|GO:0007417|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0021761|GO:0010628|GO:0036211|GO:0031981|GO:1990234|GO:0005654|GO:0044267|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0035097|GO:0016070|GO:0010557|GO:0005634|GO:0035098|GO:0045893|GO:0032774|GO:2001141|GO:0018022|GO:0008276|GO:0034968|GO:0016568|GO:0006464|GO:0008757|GO:0006351|GO:0008170|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0016279|GO:1903506|GO:0018193|GO:0042054|GO:0018024|GO:0018205 developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|methylation|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|hippocampus development|organic cyclic compound metabolic process|multicellular organism development|histone modification|animal organ development|cellular nitrogen compound metabolic process|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|head development|PcG protein complex|chromatin binding|nucleobase-containing compound metabolic process|pallium development|telencephalon development|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|methyltransferase activity|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|central nervous system development|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|limbic system development|positive regulation of gene expression|protein modification process|nuclear lumen|transferase complex|nucleoplasm|cellular protein metabolic process|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|histone methyltransferase complex|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|ESC/E(Z) complex|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|peptidyl-lysine methylation|protein methyltransferase activity|histone lysine methylation|chromatin modification|cellular protein modification process|S-adenosylmethionine-dependent methyltransferase activity|transcription, DNA-templated|N-methyltransferase activity|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|protein-lysine N-methyltransferase activity|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|histone methyltransferase activity|histone-lysine N-methyltransferase activity|peptidyl-lysine modification - - - - 17:42700275-42745049 47 68 100 173 154 229 0.291430847732819 0.383199205941157 0.559052568632878 0.961126827736339 0.783476598786876 1.33076259149354 0.411227540768951 1.02512200600559 -1.31778683067587 5.64073102379678e-05 0.000476644166386723 DOWN ENSG00000171612 SLC25A33 solute carrier family 25 (pyrimidine nucleotide carrier), member 33 [Source:HGNC Symbol;Acc:HGNC:29681] GO:0040007|GO:0005215|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0022857|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0003735|GO:0045927|GO:0043227|GO:0040008|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0019222|GO:0008284|GO:1903409|GO:0051726|GO:0042127|GO:0007049|GO:0042391|GO:0006725|GO:0019866|GO:0006810|GO:0022402|GO:1901360|GO:0034641|GO:0030307|GO:0044281|GO:0019637|GO:0046483|GO:0051128|GO:0022607|GO:0045786|GO:0043231|GO:0010243|GO:0005737|GO:0072593|GO:0031966|GO:0022891|GO:0006139|GO:0055086|GO:0007154|GO:0055085|GO:0007165|GO:0051649|GO:0009725|GO:0006091|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0001558|GO:0031323|GO:0006996|GO:0005740|GO:0034645|GO:0006518|GO:1901679|GO:0019693|GO:0007005|GO:0031930|GO:1901652|GO:0007050|GO:0097033|GO:0071417|GO:2000377|GO:0009116|GO:0046907|GO:0005743|GO:0006390|GO:0043434|GO:0010564|GO:0006259|GO:0005739|GO:0006461|GO:0051881|GO:0043467|GO:0006796|GO:0043603|GO:0044267|GO:0051174|GO:0010467|GO:0006119|GO:0071310|GO:0009059|GO:0016070|GO:0032870|GO:1903426|GO:0015932|GO:0072531|GO:0000002|GO:0002082|GO:1990519|GO:0043043|GO:0006260|GO:0034622|GO:0071156|GO:0009259|GO:1901653|GO:0009117|GO:0032774|GO:0006839|GO:0034551|GO:0043623|GO:0016310|GO:0006412|GO:0071375|GO:0032042|GO:0006163|GO:0032868|GO:0033108|GO:0042278|GO:0006351|GO:1990314|GO:0017004|GO:1903578|GO:0006261|GO:0042325|GO:0032869|GO:0006264|GO:0006864|GO:0015218|GO:0046034 growth|transporter activity|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|transmembrane transporter activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|structural constituent of ribosome|positive regulation of growth|membrane-bounded organelle|regulation of growth|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|regulation of metabolic process|positive regulation of cell proliferation|reactive oxygen species biosynthetic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of membrane potential|cellular aromatic compound metabolic process|organelle inner membrane|transport|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cell growth|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|negative regulation of cell cycle|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|reactive oxygen species metabolic process|mitochondrial membrane|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|transmembrane transport|signal transduction|establishment of localization in cell|response to hormone|generation of precursor metabolites and energy|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cell growth|regulation of cellular metabolic process|organelle organization|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|nucleotide transmembrane transport|ribose phosphate metabolic process|mitochondrion organization|mitochondria-nucleus signaling pathway|response to peptide|cell cycle arrest|mitochondrial respiratory chain complex III biogenesis|cellular response to organonitrogen compound|regulation of reactive oxygen species metabolic process|nucleoside metabolic process|intracellular transport|mitochondrial inner membrane|transcription from mitochondrial promoter|response to peptide hormone|regulation of cell cycle process|DNA metabolic process|mitochondrion|protein complex assembly|regulation of mitochondrial membrane potential|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|cellular amide metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|oxidative phosphorylation|cellular response to organic substance|macromolecule biosynthetic process|RNA metabolic process|cellular response to hormone stimulus|regulation of reactive oxygen species biosynthetic process|nucleobase-containing compound transmembrane transporter activity|pyrimidine-containing compound transmembrane transport|mitochondrial genome maintenance|regulation of oxidative phosphorylation|mitochondrial pyrimidine nucleotide import|peptide biosynthetic process|DNA replication|cellular macromolecular complex assembly|regulation of cell cycle arrest|ribonucleotide metabolic process|cellular response to peptide|nucleotide metabolic process|RNA biosynthetic process|mitochondrial transport|mitochondrial respiratory chain complex III assembly|cellular protein complex assembly|phosphorylation|translation|cellular response to peptide hormone stimulus|mitochondrial DNA metabolic process|purine nucleotide metabolic process|response to insulin|mitochondrial respiratory chain complex assembly|purine nucleoside metabolic process|transcription, DNA-templated|cellular response to insulin-like growth factor stimulus|cytochrome complex assembly|regulation of ATP metabolic process|DNA-dependent DNA replication|regulation of phosphorylation|cellular response to insulin stimulus|mitochondrial DNA replication|pyrimidine nucleotide transport|pyrimidine nucleotide transmembrane transporter activity|ATP metabolic process - - - - 1:9539482-9585179 304 311 195 131 158 106 5.57965673338756 5.18769625616203 3.22688629262255 2.15428208602521 2.37935591764406 1.82335384737762 4.66474642739071 2.1189972836823 1.13841692089846 5.67031169416234e-05 0.000479008164452525 UP ENSG00000278952 RP11-399J13.2 - - - - - - - 11:65118310-65119111 33 19 7 0 2 5 2.91060719290872 1.52305382064862 0.556624675561254 0 0.144723608254079 0.413340702791761 1.66342856303953 0.18602143701528 3.16061911866217 5.71287909071004e-05 0.000482194776290804 UP ENSG00000239405 TMED10P2 transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:38105] - - - - - - 3:128538020-128538631 1 1 2 12 6 20 0.115631851997735 0.105094324733561 0.208425006525208 1.24276181582029 0.568962420685155 2.16643127623393 0.143050394418835 1.32605183757979 -3.21254179332929 5.739425737941e-05 0.000484161672733797 DOWN ENSG00000112186 CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast) [Source:HGNC Symbol;Acc:HGNC:20039] GO:0040011|GO:0032502|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0006935|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0034641|GO:0044281|GO:0019637|GO:0031325|GO:0046483|GO:0006928|GO:0097481|GO:0014069|GO:0006139|GO:0043085|GO:0055086|GO:0007163|GO:0007154|GO:0007165|GO:0008092|GO:0050790|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0006996|GO:0000902|GO:0031175|GO:0051349|GO:0007010|GO:0019693|GO:0003779|GO:0000904|GO:0031279|GO:0006796|GO:1901137|GO:0051174|GO:0032990|GO:0007399|GO:0097485|GO:0031281|GO:0031328|GO:0030154|GO:0048858|GO:0048666|GO:0030182|GO:0007411|GO:0009259|GO:0009117|GO:0046390|GO:0061564|GO:0045761|GO:0006163|GO:0045762|GO:0022008|GO:0048667|GO:0048812|GO:0009165|GO:0006164|GO:0030801|GO:0007409|GO:0048699|GO:0007190|GO:0009187|GO:0030802|GO:0009190|GO:0046058|GO:0030819|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030816|GO:0006171 locomotion|developmental process|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|chemotaxis|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|movement of cell or subcellular component|neuronal postsynaptic density|postsynaptic density|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|establishment or maintenance of cell polarity|cell communication|signal transduction|cytoskeletal protein binding|regulation of catalytic activity|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|cell morphogenesis|neuron projection development|positive regulation of lyase activity|cytoskeleton organization|ribose phosphate metabolic process|actin binding|cell morphogenesis involved in differentiation|regulation of cyclase activity|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|neuron projection guidance|positive regulation of cyclase activity|positive regulation of cellular biosynthetic process|cell differentiation|cell projection morphogenesis|neuron development|neuron differentiation|axon guidance|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|axon development|regulation of adenylate cyclase activity|purine nucleotide metabolic process|positive regulation of adenylate cyclase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|nucleotide biosynthetic process|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|axonogenesis|generation of neurons|activation of adenylate cyclase activity|cyclic nucleotide metabolic process|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|cAMP metabolic process|positive regulation of cAMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|positive regulation of cAMP metabolic process|cAMP biosynthetic process - - - - 6:17393216-17557792 109 96 105 260 300 188 1.0473136099659 0.838302227599928 0.90960725193841 2.23831086849614 2.36504626749434 1.69291924742187 0.931741029834746 2.09875879447078 -1.17153544067606 5.74165935990903e-05 0.000484213272685662 DOWN ENSG00000257957 QRSL1P3 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:43669] - - - - - - 14:35765795-35767110 4 3 13 0 0 0 0.214995632061292 0.146574719525136 0.630000989194838 0 0 0 0.330523780260422 0 Inf 5.74640978788693e-05 0.000484477034192534 UP ENSG00000277498 RP11-681L4.2 - - - - - - - 2:61858137-61860298 12 9 3 0 1 0 0.417339732707413 0.284472046887657 0.094051515149101 0 0.0285463262459943 0 0.265287764914724 0.0095154420819981 4.8011436448636 5.7620116271538e-05 0.000485655265717249 UP ENSG00000157827 FMNL2 formin like 2 [Source:HGNC Symbol;Acc:HGNC:18267] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0009653|GO:0016043|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0051128|GO:0019899|GO:0005737|GO:0007154|GO:0007165|GO:0008092|GO:0048869|GO:0030029|GO:0006996|GO:0000902|GO:0005829|GO:0007010|GO:0003779|GO:0022604|GO:0030036|GO:0035556|GO:0051020|GO:0030866|GO:0030865|GO:0031267|GO:0007264|GO:0017016|GO:0017048 developmental process|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|anatomical structure morphogenesis|cellular component organization|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of cellular component organization|enzyme binding|cytoplasm|cell communication|signal transduction|cytoskeletal protein binding|cellular developmental process|actin filament-based process|organelle organization|cell morphogenesis|cytosol|cytoskeleton organization|actin binding|regulation of cell morphogenesis|actin cytoskeleton organization|intracellular signal transduction|GTPase binding|cortical actin cytoskeleton organization|cortical cytoskeleton organization|small GTPase binding|small GTPase mediated signal transduction|Ras GTPase binding|Rho GTPase binding - - - - 2:152335237-152649834 454 505 1097 1452 1480 1771 3.51170711648897 3.55004023778983 7.65037588416259 10.0629765238869 9.39272776426705 12.8383590010686 4.90404107948046 10.7646877630742 -1.13426350462661 5.77765606058155e-05 0.000486699052010727 DOWN ENSG00000130943 PKDREJ polycystin (PKD) family receptor for egg jelly [Source:HGNC Symbol;Acc:HGNC:9015] GO:0000003|GO:0005215|GO:0016020|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0022857|GO:0051606|GO:0044702|GO:0043167|GO:0009628|GO:0019953|GO:0009605|GO:0031224|GO:0005515|GO:0007340|GO:0006810|GO:0009612|GO:0009582|GO:0043169|GO:0022891|GO:0055085|GO:0009566|GO:0016021|GO:0046872|GO:0015267|GO:0006811|GO:0007338|GO:0015075|GO:0050982|GO:0034220|GO:0098655|GO:0005216|GO:0006812|GO:0005509|GO:0008324|GO:0022890|GO:0030001|GO:0005261|GO:0005262|GO:0070588|GO:0046873|GO:0006816|GO:0015085 reproduction|transporter activity|membrane|cellular process|reproductive process|response to stimulus|binding|transmembrane transporter activity|detection of stimulus|single organism reproductive process|ion binding|response to abiotic stimulus|sexual reproduction|response to external stimulus|intrinsic component of membrane|protein binding|acrosome reaction|transport|response to mechanical stimulus|detection of abiotic stimulus|cation binding|substrate-specific transmembrane transporter activity|transmembrane transport|fertilization|integral component of membrane|metal ion binding|channel activity|ion transport|single fertilization|ion transmembrane transporter activity|detection of mechanical stimulus|ion transmembrane transport|cation transmembrane transport|ion channel activity|cation transport|calcium ion binding|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|calcium channel activity|calcium ion transmembrane transport|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity - - - - 22:46255663-46263355 2 1 3 8 14 22 0.0183890713501014 0.00836055202611977 0.0248668636179997 0.0659101547971764 0.105620233730318 0.189587670422592 0.0172054956647403 0.120372686316695 -2.80656670861043 5.8005095450065e-05 0.000488348595478353 DOWN ENSG00000184441 AP001062.7 - - - - - - - 21:44331234-44335851 51 64 58 19 26 30 0.82856622938187 0.944967233132854 0.849577461519441 0.276574216909471 0.346578911886747 0.456787879727412 0.874370308011388 0.359980336174543 1.28032630870957 5.82372435902354e-05 0.000490164835112176 UP ENSG00000186205 MARC1 mitochondrial amidoxime reducing component 1 [Source:HGNC Symbol;Acc:HGNC:26189] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0019867|GO:0031224|GO:0005622|GO:0031090|GO:0051410|GO:0019866|GO:0006082|GO:0043168|GO:0044281|GO:2001057|GO:0043231|GO:0043169|GO:0005737|GO:0043546|GO:0031966|GO:0030170|GO:0050662|GO:0016021|GO:0055114|GO:0009636|GO:0005740|GO:0046872|GO:0008940|GO:0005741|GO:0005743|GO:0005739|GO:0042126|GO:0046914|GO:0030151 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|outer membrane|intrinsic component of membrane|intracellular|organelle membrane|detoxification of nitrogen compound|organelle inner membrane|organic acid metabolic process|anion binding|small molecule metabolic process|reactive nitrogen species metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|molybdopterin cofactor binding|mitochondrial membrane|pyridoxal phosphate binding|coenzyme binding|integral component of membrane|oxidation-reduction process|response to toxic substance|mitochondrial envelope|metal ion binding|nitrate reductase activity|mitochondrial outer membrane|mitochondrial inner membrane|mitochondrion|nitrate metabolic process|transition metal ion binding|molybdenum ion binding - - - - 1:220786759-220819657 194 215 313 562 616 398 1.14971295420853 1.1579926584834 1.67242205615937 2.9841505461639 2.99526540827286 2.2105429748325 1.32670922295043 2.72998630975642 -1.0410415088835 5.85387471288893e-05 0.000492147495574729 DOWN ENSG00000135537 LACE1 lactation elevated 1 [Source:HGNC Symbol;Acc:HGNC:16411] GO:0005623|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0043168|GO:0001882|GO:0043231|GO:0005737|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0005739|GO:0017076|GO:0005524|GO:0030554 cell|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|anion binding|nucleoside binding|intracellular membrane-bounded organelle|cytoplasm|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|mitochondrion|purine nucleotide binding|ATP binding|adenyl nucleotide binding - - - - 6:108294894-108526796 10 32 25 70 63 81 0.0678044123352809 0.19720031312598 0.152839141654617 0.425281005181589 0.350499814167274 0.514747943165182 0.139281289038626 0.430176254171348 -1.62692642965367 5.85737217938169e-05 0.000492302897081253 DOWN ENSG00000165392 WRN Werner syndrome, RecQ helicase-like [Source:HGNC Symbol;Acc:HGNC:12791] GO:0032502|GO:0040007|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0040008|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042802|GO:0006281|GO:0006725|GO:0009314|GO:0006810|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043168|GO:0016788|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0007420|GO:0043231|GO:0000723|GO:0043169|GO:0031668|GO:0060322|GO:0032403|GO:0042592|GO:0043005|GO:0046983|GO:0003682|GO:0006979|GO:0006139|GO:0043085|GO:0031297|GO:0032300|GO:0007154|GO:0051649|GO:0008219|GO:0050790|GO:0000166|GO:0048869|GO:0044249|GO:0019538|GO:1990391|GO:0042594|GO:0040009|GO:0006996|GO:0007568|GO:0051276|GO:0005730|GO:0003677|GO:0005813|GO:0034645|GO:0046872|GO:0000725|GO:0035639|GO:0043412|GO:0007417|GO:0051345|GO:0005815|GO:0001883|GO:0032389|GO:0006284|GO:0006302|GO:0016818|GO:0036211|GO:0046907|GO:0032549|GO:0010259|GO:0007569|GO:0031981|GO:0004518|GO:0000731|GO:0071478|GO:0005654|GO:0006259|GO:0009267|GO:0012501|GO:0010212|GO:0044267|GO:0007399|GO:0017076|GO:0009059|GO:0031669|GO:0031667|GO:0005856|GO:0005634|GO:0009416|GO:0042803|GO:0043067|GO:0006974|GO:0000724|GO:0010332|GO:0032200|GO:0006260|GO:0009411|GO:0043566|GO:0051169|GO:0000287|GO:0005524|GO:0030554|GO:0004527|GO:0015630|GO:0006310|GO:0042981|GO:0046914|GO:0090305|GO:0071479|GO:0006464|GO:0071103|GO:0016462|GO:0001302|GO:0071897|GO:0032066|GO:0006915|GO:0006261|GO:0030145|GO:0008408|GO:0071480|GO:0032392|GO:0045003|GO:0017111|GO:0018193|GO:0051880|GO:0043687|GO:0010225|GO:0032446|GO:0016887|GO:0000405|GO:0032508|GO:0000403|GO:0004386|GO:0018205|GO:0003678|GO:0042623|GO:0016925|GO:0009378|GO:0043138|GO:0008026|GO:0008094|GO:0004003|GO:0043140 developmental process|growth|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|regulation of growth|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|identical protein binding|DNA repair|cellular aromatic compound metabolic process|response to radiation|transport|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|brain development|intracellular membrane-bounded organelle|telomere maintenance|cation binding|cellular response to extracellular stimulus|head development|protein complex binding|homeostatic process|neuron projection|protein dimerization activity|chromatin binding|response to oxidative stress|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|replication fork processing|mismatch repair complex|cell communication|establishment of localization in cell|cell death|regulation of catalytic activity|nucleotide binding|cellular developmental process|cellular biosynthetic process|protein metabolic process|DNA repair complex|response to starvation|regulation of growth rate|organelle organization|aging|chromosome organization|nucleolus|DNA binding|centrosome|cellular macromolecule biosynthetic process|metal ion binding|recombinational repair|purine ribonucleoside triphosphate binding|macromolecule modification|central nervous system development|positive regulation of hydrolase activity|microtubule organizing center|purine nucleoside binding|MutLalpha complex|base-excision repair|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|intracellular transport|ribonucleoside binding|multicellular organism aging|cell aging|nuclear lumen|nuclease activity|DNA synthesis involved in DNA repair|cellular response to radiation|nucleoplasm|DNA metabolic process|cellular response to starvation|programmed cell death|response to ionizing radiation|cellular protein metabolic process|nervous system development|purine nucleotide binding|macromolecule biosynthetic process|cellular response to nutrient levels|response to nutrient levels|cytoskeleton|nucleus|response to light stimulus|protein homodimerization activity|regulation of programmed cell death|cellular response to DNA damage stimulus|double-strand break repair via homologous recombination|response to gamma radiation|telomere organization|DNA replication|response to UV|structure-specific DNA binding|nuclear transport|magnesium ion binding|ATP binding|adenyl nucleotide binding|exonuclease activity|microtubule cytoskeleton|DNA recombination|regulation of apoptotic process|transition metal ion binding|nucleic acid phosphodiester bond hydrolysis|cellular response to ionizing radiation|cellular protein modification process|DNA conformation change|pyrophosphatase activity|replicative cell aging|DNA biosynthetic process|nucleolus to nucleoplasm transport|apoptotic process|DNA-dependent DNA replication|manganese ion binding|3'-5' exonuclease activity|cellular response to gamma radiation|DNA geometric change|double-strand break repair via synthesis-dependent strand annealing|nucleoside-triphosphatase activity|peptidyl-amino acid modification|G-quadruplex DNA binding|post-translational protein modification|response to UV-C|protein modification by small protein conjugation|ATPase activity|bubble DNA binding|DNA duplex unwinding|Y-form DNA binding|helicase activity|peptidyl-lysine modification|DNA helicase activity|ATPase activity, coupled|protein sumoylation|four-way junction helicase activity|3'-5' DNA helicase activity|ATP-dependent helicase activity|DNA-dependent ATPase activity|ATP-dependent DNA helicase activity|ATP-dependent 3'-5' DNA helicase activity - - - - 8:31033801-31173769 78 110 112 219 231 220 0.812828956062532 1.04178008672623 1.05228956667217 2.04477398855428 1.97507269255924 2.14860009113265 0.968966203153644 2.05614892408206 -1.08542650930214 5.86391443964755e-05 0.000492436854236956 DOWN ENSG00000267022 AC084219.2 - GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:44025354-44087318 0 49 5 0 0 0 0 0.836459964559818 0.0846672559231807 0 0 0 0.307042406827666 0 Inf 5.86242504048973e-05 0.000492436854236956 UP ENSG00000243406 MRPS31P5 mitochondrial ribosomal protein S31 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:39253] - - - - - - 13:52167709-52194465 260 203 132 93 94 76 3.52396776372075 2.50054660791511 1.6130489784451 1.12937246190716 1.04532677095667 0.965386338275568 2.54585445002699 1.0466951903798 1.28230856663206 5.89460827672575e-05 0.000494597064343368 UP ENSG00000168916 ZNF608 zinc finger protein 608 [Source:HGNC Symbol;Acc:HGNC:29238] GO:0005488|GO:0043167|GO:0043169|GO:0046872 binding|ion binding|cation binding|metal ion binding - - - - 5:124636913-124748807 11 2 34 65 80 95 0.0504605916280327 0.0083381714758845 0.140621726299256 0.267159216855651 0.301107787346593 0.408425518491416 0.0664734964677244 0.32556417423122 -2.29209080519728 5.92693005199517e-05 0.000497169344681832 DOWN ENSG00000172667 ZMAT3 zinc finger, matrin-type 3 [Source:HGNC Symbol;Acc:HGNC:29983] GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0043167|GO:0043227|GO:0040008|GO:0005622|GO:0005515|GO:0006810|GO:0010941|GO:0003676|GO:0002039|GO:0033554|GO:0010942|GO:0043231|GO:0043169|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0008219|GO:0005730|GO:0046872|GO:0003723|GO:0015031|GO:0031981|GO:0012501|GO:0035556|GO:0043068|GO:0005634|GO:0043067|GO:0006974|GO:0097190|GO:0097193|GO:0043065|GO:0072331|GO:0042981|GO:0046914|GO:0044822|GO:0006915|GO:0072332|GO:0008270 growth|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|ion binding|membrane-bounded organelle|regulation of growth|intracellular|protein binding|transport|regulation of cell death|nucleic acid binding|p53 binding|cellular response to stress|positive regulation of cell death|intracellular membrane-bounded organelle|cation binding|establishment of protein localization|protein localization|cell communication|signal transduction|cell death|nucleolus|metal ion binding|RNA binding|protein transport|nuclear lumen|programmed cell death|intracellular signal transduction|positive regulation of programmed cell death|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|positive regulation of apoptotic process|signal transduction by p53 class mediator|regulation of apoptotic process|transition metal ion binding|poly(A) RNA binding|apoptotic process|intrinsic apoptotic signaling pathway by p53 class mediator|zinc ion binding K10137 zinc finger, matrin type 3[-] hsa04115 p53 signaling pathway - Homo sapiens (human) 3:179017223-179072279 51 99 224 353 320 525 0.302370074824295 0.53344005787325 1.19737517032448 1.87517421932563 1.5566349912698 2.91713924749199 0.677728434340675 2.11631615269581 -1.64277595856611 5.92973908841736e-05 0.000497265254903404 DOWN ENSG00000229320 KRT8P12 keratin 8 pseudogene 12 [Source:HGNC Symbol;Acc:HGNC:28057] - - - - - - 3:160565447-160569248 197 206 181 91 130 64 5.81843063874866 5.52951324771955 4.81984427716632 2.40811405990806 3.15029845111714 1.77154565268358 5.38926272121151 2.44331938790293 1.14124545502382 5.93947157871891e-05 0.000497801753259613 UP ENSG00000189051 RNF222 ring finger protein 222 [Source:HGNC Symbol;Acc:HGNC:34517] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0032182|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0008134|GO:0019787|GO:0000151|GO:0016021|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0032183|GO:0051252|GO:0044265|GO:0010628|GO:0036211|GO:0032269|GO:1990234|GO:0006508|GO:0044267|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0016070|GO:0010557|GO:0005634|GO:0000152|GO:0044257|GO:0045893|GO:0061630|GO:0010498|GO:0032774|GO:2001141|GO:0033768|GO:0051603|GO:0032184|GO:0046914|GO:0006464|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0019941|GO:1903506|GO:0018193|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0033234|GO:0033233|GO:0018205|GO:0016925|GO:0016567 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|ubiquitin-like protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|transcription factor binding|ubiquitin-like protein transferase activity|ubiquitin ligase complex|integral component of membrane|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|SUMO binding|regulation of RNA metabolic process|cellular macromolecule catabolic process|positive regulation of gene expression|protein modification process|negative regulation of cellular protein metabolic process|transferase complex|proteolysis|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|nuclear ubiquitin ligase complex|cellular protein catabolic process|positive regulation of transcription, DNA-templated|ubiquitin protein ligase activity|proteasomal protein catabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|SUMO-targeted ubiquitin ligase complex|proteolysis involved in cellular protein catabolic process|SUMO polymer binding|transition metal ion binding|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|negative regulation of protein sumoylation|regulation of protein sumoylation|peptidyl-lysine modification|protein sumoylation|protein ubiquitination - - - - 17:8390704-8397826 30 30 49 13 14 13 0.362871605573504 0.329791221335856 0.534374901728515 0.140889026125655 0.138942622791952 0.147376149694107 0.409012576212625 0.142402599537238 1.52216972074441 5.95725545736087e-05 0.000499012077508561 UP ENSG00000130487 KLHDC7B kelch domain containing 7B [Source:HGNC Symbol;Acc:HGNC:25145] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0044237|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0004842|GO:0031461|GO:0036211|GO:1990234|GO:0044267|GO:0006464|GO:0031463|GO:0032446|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|cellular metabolic process|intracellular|protein binding|protein complex|transferase activity|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|protein modification process|transferase complex|cellular protein metabolic process|cellular protein modification process|Cul3-RING ubiquitin ligase complex|protein modification by small protein conjugation|protein ubiquitination - - - - 22:50548033-50551023 1 4 4 15 16 16 0.0236598774398575 0.0859743257493407 0.0852932825098141 0.317847118019558 0.310466329624576 0.354634891188329 0.0649758285663374 0.327649446277488 -2.33417806254369 6.00754835849545e-05 0.000502660730646085 DOWN ENSG00000066379 ZNRD1 zinc ribbon domain containing 1 [Source:HGNC Symbol;Acc:HGNC:13182] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0009892|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016772|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0005730|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0031981|GO:1990234|GO:0005654|GO:0010467|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0005736|GO:0045814|GO:0032774|GO:0040029|GO:0046914|GO:0006351|GO:0006352|GO:0003899|GO:0006360|GO:0006354|GO:0006353|GO:0008270|GO:0006361|GO:0006362|GO:0006363|GO:0001054 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|negative regulation of metabolic process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|nucleolus|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|nuclear lumen|transferase complex|nucleoplasm|gene expression|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|DNA-directed RNA polymerase I complex|negative regulation of gene expression, epigenetic|RNA biosynthetic process|regulation of gene expression, epigenetic|transition metal ion binding|transcription, DNA-templated|DNA-templated transcription, initiation|DNA-directed RNA polymerase activity|transcription from RNA polymerase I promoter|DNA-templated transcription, elongation|DNA-templated transcription, termination|zinc ion binding|transcription initiation from RNA polymerase I promoter|transcription elongation from RNA polymerase I promoter|termination of RNA polymerase I transcription|RNA polymerase I activity - - - - 6:30058899-30064909 351 422 266 179 209 162 5.01892867625059 5.48399076747181 3.42924895747921 2.29327268373907 2.45198779941897 2.17093805729694 4.64405613373387 2.30539951348499 1.01036862677882 6.0149710570277e-05 0.000503140784355576 UP ENSG00000111860 CEP85L centrosomal protein 85kDa-like [Source:HGNC Symbol;Acc:HGNC:21638] GO:0005623|GO:0043229|GO:0005622|GO:0005737|GO:0005813|GO:0005815|GO:0005856|GO:0015630 cell|intracellular organelle|intracellular|cytoplasm|centrosome|microtubule organizing center|cytoskeleton|microtubule cytoskeleton - - - - 6:118460772-118710075 45 47 76 139 157 118 0.179455180124009 0.170342407395092 0.273255071318229 0.496654074889831 0.513697963638283 0.441013935566375 0.207684219612443 0.483788658031496 -1.21998534646787 6.05530768233586e-05 0.000505996162169135 DOWN ENSG00000267325 LINC01415 long intergenic non-protein coding RNA 1415 [Source:HGNC Symbol;Acc:HGNC:50709] - - - - - - 18:55776727-55781721 2 1 1 11 11 14 0.0279911210716918 0.0127261034303402 0.0126127182073297 0.137941693622707 0.1263167583465 0.183644928529651 0.0177766475697872 0.149301126832953 -3.07016987151473 6.055886271288e-05 0.000505996162169135 DOWN ENSG00000105708 ZNF14 zinc finger protein 14 [Source:HGNC Symbol;Acc:HGNC:12924] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:19710471-19733097 77 92 64 32 28 41 1.84697058675139 2.00557198754642 1.38408336082814 0.687732507699785 0.55105897462688 0.921691469731587 1.74554197837532 0.720160984019417 1.27728370631413 6.07909778240122e-05 0.000507793467251836 UP ENSG00000138767 CNOT6L CCR4-NOT transcription complex subunit 6-like [Source:HGNC Symbol;Acc:HGNC:18042] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0008284|GO:0042127|GO:1902117|GO:0006725|GO:1902115|GO:0051130|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0051128|GO:0022607|GO:0043231|GO:0043169|GO:0030014|GO:0005737|GO:0009890|GO:0016458|GO:0006139|GO:0044249|GO:0022613|GO:0019538|GO:0043487|GO:0031324|GO:0031323|GO:0006996|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0010603|GO:0031047|GO:0010629|GO:0051252|GO:0044265|GO:0032269|GO:0022618|GO:0004518|GO:0010606|GO:0070925|GO:0043603|GO:0033043|GO:0044267|GO:0010467|GO:0050779|GO:0019439|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0043488|GO:0010638|GO:0006401|GO:0043043|GO:0090501|GO:0034622|GO:0006396|GO:0032774|GO:0017148|GO:2001141|GO:0010608|GO:0061157|GO:0006412|GO:0004527|GO:0016071|GO:0006417|GO:0004540|GO:0090305|GO:0033962|GO:0006351|GO:0006355|GO:0004532|GO:0008408|GO:1903506|GO:0006402|GO:0006397|GO:0090503|GO:0000956|GO:0000175|GO:0016896|GO:0000289|GO:0004535|GO:0000288 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|positive regulation of organelle assembly|cellular aromatic compound metabolic process|regulation of organelle assembly|positive regulation of cellular component organization|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cation binding|CCR4-NOT complex|cytoplasm|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|protein metabolic process|regulation of RNA stability|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|regulation of cytoplasmic mRNA processing body assembly|gene silencing by RNA|negative regulation of gene expression|regulation of RNA metabolic process|cellular macromolecule catabolic process|negative regulation of cellular protein metabolic process|ribonucleoprotein complex assembly|nuclease activity|positive regulation of cytoplasmic mRNA processing body assembly|organelle assembly|cellular amide metabolic process|regulation of organelle organization|cellular protein metabolic process|gene expression|RNA destabilization|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulation of mRNA stability|positive regulation of organelle organization|RNA catabolic process|peptide biosynthetic process|RNA phosphodiester bond hydrolysis|cellular macromolecular complex assembly|RNA processing|RNA biosynthetic process|negative regulation of translation|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|mRNA destabilization|translation|exonuclease activity|mRNA metabolic process|regulation of translation|ribonuclease activity|nucleic acid phosphodiester bond hydrolysis|cytoplasmic mRNA processing body assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|exoribonuclease activity|3'-5' exonuclease activity|regulation of nucleic acid-templated transcription|mRNA catabolic process|mRNA processing|RNA phosphodiester bond hydrolysis, exonucleolytic|nuclear-transcribed mRNA catabolic process|3'-5'-exoribonuclease activity|exoribonuclease activity, producing 5'-phosphomonoesters|nuclear-transcribed mRNA poly(A) tail shortening|poly(A)-specific ribonuclease activity|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay K12603 CCR4-NOT transcription complex subunit 6[3.1.13.4] hsa03018 RNA degradation - Homo sapiens (human) 4:77713387-77819615 47 119 65 356 213 175 0.237780225356601 0.547147716497435 0.296486429499054 1.61370434197458 0.88414535197863 0.829744406584116 0.360471457117697 1.10919803351244 -1.62156003025393 6.087686142023e-05 0.000508368621213859 DOWN ENSG00000232160 RAP2C-AS1 RAP2C antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40957] - - - - - - X:132217147-132432862 2 1 5 13 22 12 0.0364043041421333 0.0165511391500101 0.082052724088188 0.212022394437166 0.328581552937559 0.204709073927694 0.0450027224601105 0.248437673767473 -2.4647997786787 6.1084146014397e-05 0.000509956961720864 DOWN ENSG00000105675 ATP4A ATPase, H+/K+ exchanging, alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:819] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0043167|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005615|GO:0005622|GO:0005886|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0005887|GO:0043231|GO:0043169|GO:0042592|GO:0019725|GO:0022891|GO:0031226|GO:0055085|GO:0000166|GO:0071804|GO:0016021|GO:0016820|GO:0046872|GO:0035639|GO:0048878|GO:0001883|GO:0016818|GO:0006811|GO:0032549|GO:0055082|GO:0015075|GO:0017076|GO:0071805|GO:0090662|GO:0034220|GO:0098655|GO:0010248|GO:0015992|GO:0000287|GO:0005524|GO:0010107|GO:0006812|GO:0030554|GO:0015991|GO:0042625|GO:0050801|GO:0042626|GO:0016462|GO:0006873|GO:0008324|GO:0019829|GO:1902600|GO:0017111|GO:0022890|GO:0030001|GO:0030003|GO:0015672|GO:0016887|GO:0006813|GO:0035725|GO:0006814|GO:0055065|GO:0006875|GO:0015077|GO:0046873|GO:0015079|GO:0005391|GO:0042623|GO:0030007|GO:0071436|GO:0055075|GO:0015078|GO:0006883|GO:0055078|GO:0008900|GO:0015081|GO:0043492|GO:0036376 transporter activity|cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|ion binding|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|extracellular space|intracellular|plasma membrane|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|nucleotide binding|cellular potassium ion transport|integral component of membrane|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|metal ion binding|purine ribonucleoside triphosphate binding|chemical homeostasis|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|ribonucleoside binding|cellular chemical homeostasis|ion transmembrane transporter activity|purine nucleotide binding|potassium ion transmembrane transport|ATP hydrolysis coupled transmembrane transport|ion transmembrane transport|cation transmembrane transport|establishment or maintenance of transmembrane electrochemical gradient|proton transport|magnesium ion binding|ATP binding|potassium ion import|cation transport|adenyl nucleotide binding|ATP hydrolysis coupled proton transport|ATPase coupled ion transmembrane transporter activity|ion homeostasis|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|cellular ion homeostasis|cation transmembrane transporter activity|cation-transporting ATPase activity|hydrogen ion transmembrane transport|nucleoside-triphosphatase activity|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|monovalent inorganic cation transport|ATPase activity|potassium ion transport|sodium ion transmembrane transport|sodium ion transport|metal ion homeostasis|cellular metal ion homeostasis|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium ion transmembrane transporter activity|sodium:potassium-exchanging ATPase activity|ATPase activity, coupled|cellular potassium ion homeostasis|sodium ion export|potassium ion homeostasis|hydrogen ion transmembrane transporter activity|cellular sodium ion homeostasis|sodium ion homeostasis|hydrogen:potassium-exchanging ATPase activity|sodium ion transmembrane transporter activity|ATPase activity, coupled to movement of substances|sodium ion export from cell K01542 H+/K+-exchanging ATPase alpha polypeptide[3.6.3.10] hsa00190|hsa04971 Oxidative phosphorylation - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human) 19:35550043-35563658 3 11 8 0 1 0 0.041835958864369 0.139402867638012 0.100576466779757 0 0.0114455406237635 0 0.093938431094046 0.00381518020792117 4.62189239004739 6.13967994929788e-05 0.000511994427950667 UP ENSG00000271447 MMP28 matrix metallopeptidase 28 [Source:HGNC Symbol;Acc:HGNC:14366] GO:0040011|GO:0031012|GO:0002376|GO:0007610|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0040013|GO:0002683|GO:0048523|GO:0048521|GO:0050794|GO:0040012|GO:0005578|GO:0071704|GO:0050900|GO:0043167|GO:0050795|GO:0048870|GO:0009605|GO:0016787|GO:0005622|GO:0002682|GO:0006935|GO:0002685|GO:0043169|GO:0008233|GO:0005737|GO:0050920|GO:0006928|GO:0051270|GO:0016477|GO:0002686|GO:0050922|GO:0051271|GO:0030595|GO:2000145|GO:0019538|GO:2000146|GO:0048246|GO:0002688|GO:0046872|GO:0030334|GO:0060326|GO:0006508|GO:0030336|GO:0002689|GO:0008237|GO:0005509|GO:0010760|GO:0004175|GO:0010758|GO:0046914|GO:0008270|GO:0004222 locomotion|extracellular matrix|immune system process|behavior|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of locomotion|negative regulation of immune system process|negative regulation of cellular process|negative regulation of behavior|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|organic substance metabolic process|leukocyte migration|ion binding|regulation of behavior|cell motility|response to external stimulus|hydrolase activity|intracellular|regulation of immune system process|chemotaxis|regulation of leukocyte migration|cation binding|peptidase activity|cytoplasm|regulation of chemotaxis|movement of cell or subcellular component|regulation of cellular component movement|cell migration|negative regulation of leukocyte migration|negative regulation of chemotaxis|negative regulation of cellular component movement|leukocyte chemotaxis|regulation of cell motility|protein metabolic process|negative regulation of cell motility|macrophage chemotaxis|regulation of leukocyte chemotaxis|metal ion binding|regulation of cell migration|cell chemotaxis|proteolysis|negative regulation of cell migration|negative regulation of leukocyte chemotaxis|metallopeptidase activity|calcium ion binding|negative regulation of macrophage chemotaxis|endopeptidase activity|regulation of macrophage chemotaxis|transition metal ion binding|zinc ion binding|metalloendopeptidase activity - - - - 17:35756249-35795707 45 40 100 141 159 290 0.650557119362287 0.525545081373959 1.30342769322785 1.82636658197619 1.88596828384133 3.92913626181318 0.826509964654699 2.54715704254357 -1.62378379204023 6.16564066414571e-05 0.000513872240054176 DOWN ENSG00000158825 CDA cytidine deaminase [Source:HGNC Symbol;Acc:HGNC:1712] GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0016049|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0045926|GO:0016043|GO:0040008|GO:0016787|GO:0009058|GO:0019239|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0006725|GO:0004126|GO:1901360|GO:0034641|GO:0044281|GO:0001882|GO:0019637|GO:0046483|GO:0051128|GO:0022607|GO:0043169|GO:0030308|GO:0005737|GO:0016810|GO:0046983|GO:0006139|GO:0055086|GO:0007154|GO:0007165|GO:0044249|GO:0001558|GO:0031324|GO:0031323|GO:0005829|GO:0046872|GO:0007166|GO:0009116|GO:0006461|GO:0006796|GO:1901137|GO:0051174|GO:0019439|GO:0016814|GO:0042803|GO:0006213|GO:0051259|GO:0009117|GO:0045980|GO:0006206|GO:0046914|GO:0008655|GO:0019858|GO:0046135|GO:0046134|GO:0043097|GO:0051260|GO:0051262|GO:0008270|GO:0051289|GO:0009972 growth|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|cell growth|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|negative regulation of growth|cellular component organization|regulation of growth|hydrolase activity|biosynthetic process|deaminase activity|intracellular|protein binding|regulation of metabolic process|identical protein binding|cellular aromatic compound metabolic process|cytidine deaminase activity|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|nucleoside binding|organophosphate metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|cation binding|negative regulation of cell growth|cytoplasm|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|protein dimerization activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|signal transduction|cellular biosynthetic process|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cytosol|metal ion binding|cell surface receptor signaling pathway|nucleoside metabolic process|protein complex assembly|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|aromatic compound catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|protein homodimerization activity|pyrimidine nucleoside metabolic process|protein oligomerization|nucleotide metabolic process|negative regulation of nucleotide metabolic process|pyrimidine nucleobase metabolic process|transition metal ion binding|pyrimidine-containing compound salvage|cytosine metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside biosynthetic process|pyrimidine nucleoside salvage|protein homooligomerization|protein tetramerization|zinc ion binding|protein homotetramerization|cytidine deamination K01489 cytidine deaminase[3.5.4.5] hsa01100|hsa00240|hsa00983 Metabolic pathways - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human) 1:20588948-20618908 150 155 338 467 494 575 6.57811423984317 6.17765793361044 13.3641956528576 18.3495749132704 17.7748633473945 23.6324232679574 8.70665594210374 19.9189538428741 -1.1939512589605 6.19803680464144e-05 0.000516428107077213 DOWN ENSG00000214050 FBXO16 F-box protein 16 [Source:HGNC Symbol;Acc:HGNC:13618] GO:0005488|GO:0005515 binding|protein binding - - - - 8:28348287-28490318 22 25 40 67 86 81 0.254157217999106 0.262487828945714 0.416634873675454 0.693509199596246 0.815170191465585 0.876996659006889 0.311093306873425 0.795225350022907 -1.35401639172054 6.22807331194802e-05 0.000518352106648721 DOWN ENSG00000120093 HOXB3 homeobox B3 [Source:HGNC Symbol;Acc:HGNC:5114] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0001568|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0030902|GO:0046483|GO:0007420|GO:0043231|GO:0007389|GO:0060322|GO:0009887|GO:0048598|GO:0048568|GO:0009890|GO:0006139|GO:0001525|GO:0021675|GO:0021602|GO:0060324|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0048732|GO:0021546|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0051216|GO:0001944|GO:0030097|GO:0072358|GO:0007417|GO:0010629|GO:0051252|GO:0009790|GO:0030878|GO:0003002|GO:0035270|GO:0021615|GO:0010467|GO:0048562|GO:0007399|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0016070|GO:0072359|GO:0005634|GO:0051960|GO:0021545|GO:0048706|GO:0000975|GO:0009792|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0021563|GO:0009952|GO:0002244|GO:0048704|GO:0060216|GO:0022008|GO:0050767|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0043009|GO:0000122|GO:0001047|GO:0000976|GO:0001012|GO:0001046|GO:0000977|GO:0000979 developmental process|immune system process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|immune system development|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|hindbrain development|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|pattern specification process|head development|organ morphogenesis|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|angiogenesis|nerve development|cranial nerve morphogenesis|face development|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|rhombomere development|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|vasculature development|hemopoiesis|cardiovascular system development|central nervous system development|negative regulation of gene expression|regulation of RNA metabolic process|embryo development|thyroid gland development|regionalization|endocrine system development|glossopharyngeal nerve morphogenesis|gene expression|embryonic organ morphogenesis|nervous system development|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|RNA metabolic process|circulatory system development|nucleus|regulation of nervous system development|cranial nerve development|embryonic skeletal system development|regulatory region DNA binding|embryo development ending in birth or egg hatching|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|glossopharyngeal nerve development|anterior/posterior pattern specification|hematopoietic progenitor cell differentiation|embryonic skeletal system morphogenesis|definitive hemopoiesis|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding - - - - 17:48548870-48604912 81 67 123 186 212 292 0.327693266975774 0.246341416297142 0.448639792757088 0.674203824741149 0.703695464977397 1.10711096481598 0.340891492010001 0.828336751511509 -1.28090480626914 6.23448999056502e-05 0.000518741538958551 DOWN ENSG00000172250 SERHL serine hydrolase-like (pseudogene) [Source:HGNC Symbol;Acc:HGNC:14408] - - - - - - 22:42500579-42512560 37 25 19 6 9 9 0.93406182030887 0.573594923852465 0.432458820043072 0.135719170464314 0.186415618438058 0.212934412972828 0.646705188068136 0.178356400625067 1.85834519385856 6.26297926979831e-05 0.000520966796100749 UP ENSG00000137868 STRA6 stimulated by retinoic acid 6 [Source:HGNC Symbol;Acc:HGNC:30650] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0005215|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0051716|GO:0007631|GO:0004872|GO:0051606|GO:0050794|GO:0048520|GO:0044702|GO:0071704|GO:0009628|GO:0051183|GO:0044237|GO:0050795|GO:0003006|GO:0009653|GO:0044708|GO:0071944|GO:0009605|GO:0031224|GO:0048589|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0048514|GO:0007507|GO:0044255|GO:0048565|GO:0060900|GO:0003179|GO:0048286|GO:0035239|GO:0001822|GO:0060430|GO:0009888|GO:0009314|GO:0035295|GO:0009612|GO:0001568|GO:0061038|GO:0007275|GO:0007638|GO:0030324|GO:0048513|GO:0050877|GO:0060065|GO:0060325|GO:0009582|GO:0061061|GO:0048608|GO:0003170|GO:0060322|GO:0007423|GO:0009887|GO:0048598|GO:0048568|GO:0007548|GO:0030323|GO:0010171|GO:0007154|GO:0061029|GO:0006629|GO:0007165|GO:0003279|GO:0060323|GO:0061205|GO:0007611|GO:0060324|GO:0016021|GO:0048806|GO:0048732|GO:0003205|GO:0060426|GO:0050905|GO:0030540|GO:0055123|GO:0043584|GO:0001654|GO:0001944|GO:0009583|GO:0061458|GO:0072358|GO:0007612|GO:0001655|GO:0043583|GO:0006720|GO:0060541|GO:0009790|GO:0060840|GO:0060537|GO:0048844|GO:0031223|GO:0072001|GO:0007602|GO:0035270|GO:0003231|GO:0061143|GO:0030325|GO:0060429|GO:0048562|GO:0050890|GO:0010996|GO:0003281|GO:0007517|GO:0048566|GO:0048546|GO:0072359|GO:0060428|GO:0003184|GO:0009416|GO:0031076|GO:0060538|GO:0061156|GO:0043010|GO:0048048|GO:0043585|GO:0009584|GO:0048745|GO:0007603|GO:0048596|GO:0098597|GO:0097070|GO:0060539|GO:0048592|GO:0042297|GO:0048593|GO:0016101|GO:0001523 developmental process|growth|macromolecular complex|reproduction|transporter activity|behavior|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|cellular response to stimulus|feeding behavior|receptor activity|detection of stimulus|regulation of cellular process|positive regulation of behavior|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|vitamin transporter activity|cellular metabolic process|regulation of behavior|developmental process involved in reproduction|anatomical structure morphogenesis|single-organism behavior|cell periphery|response to external stimulus|intrinsic component of membrane|developmental growth|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|heart development|cellular lipid metabolic process|digestive tract development|embryonic camera-type eye formation|heart valve morphogenesis|lung alveolus development|tube morphogenesis|kidney development|lung saccule development|tissue development|response to radiation|tube development|response to mechanical stimulus|blood vessel development|uterus morphogenesis|multicellular organism development|mechanosensory behavior|lung development|animal organ development|neurological system process|uterus development|face morphogenesis|detection of abiotic stimulus|muscle structure development|reproductive structure development|heart valve development|head development|sensory organ development|organ morphogenesis|embryonic morphogenesis|embryonic organ development|sex differentiation|respiratory tube development|body morphogenesis|cell communication|eyelid development in camera-type eye|lipid metabolic process|signal transduction|cardiac septum development|head morphogenesis|paramesonephric duct development|learning or memory|face development|integral component of membrane|genitalia development|gland development|cardiac chamber development|lung vasculature development|neuromuscular process|female genitalia development|digestive system development|nose development|eye development|vasculature development|detection of light stimulus|reproductive system development|cardiovascular system development|learning|urogenital system development|ear development|isoprenoid metabolic process|respiratory system development|embryo development|artery development|muscle tissue development|artery morphogenesis|auditory behavior|renal system development|phototransduction|endocrine system development|cardiac ventricle development|alveolar primary septum development|adrenal gland development|epithelium development|embryonic organ morphogenesis|cognition|response to auditory stimulus|ventricular septum development|muscle organ development|embryonic digestive tract development|digestive tract morphogenesis|circulatory system development|lung epithelium development|pulmonary valve morphogenesis|response to light stimulus|embryonic camera-type eye development|skeletal muscle organ development|pulmonary artery morphogenesis|camera-type eye development|embryonic eye morphogenesis|nose morphogenesis|detection of visible light|smooth muscle tissue development|phototransduction, visible light|embryonic camera-type eye morphogenesis|observational learning|ductus arteriosus closure|diaphragm development|eye morphogenesis|vocal learning|camera-type eye morphogenesis|diterpenoid metabolic process|retinoid metabolic process - - - - 15:74179466-74212267 265 296 453 586 672 972 1.39256286338859 1.41364247941494 2.14625138908277 2.75907415967344 2.89738011629851 4.78700348662344 1.65081891062877 3.4811525875318 -1.07638318228177 6.31243440867396e-05 0.000524934308736915 DOWN ENSG00000090975 PITPNM2 phosphatidylinositol transfer protein, membrane associated 2 [Source:HGNC Symbol;Acc:HGNC:21044] GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0008289|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0043231|GO:0043169|GO:0016021|GO:0046872|GO:0005509 cell|membrane|metabolic process|binding|intracellular organelle|ion binding|membrane-bounded organelle|lipid binding|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transport|intracellular membrane-bounded organelle|cation binding|integral component of membrane|metal ion binding|calcium ion binding - - - - 12:122983480-123150015 226 253 389 516 616 692 1.18401082037648 1.20461545331525 1.83743357408984 2.42211745930395 2.64786608747925 3.39768317100532 1.40868661592719 2.82255557259617 -1.00265128857182 6.31608246703059e-05 0.000525091411781485 DOWN ENSG00000188505 NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) [Source:HGNC Symbol;Acc:HGNC:33739] GO:0005623|GO:0009987|GO:0005576|GO:1903561|GO:0008283|GO:0050794|GO:0043227|GO:0005622|GO:0008284|GO:0042127|GO:0031982|GO:0005737|GO:0070062 cell|cellular process|extracellular region|extracellular vesicle|cell proliferation|regulation of cellular process|membrane-bounded organelle|intracellular|positive regulation of cell proliferation|regulation of cell proliferation|vesicle|cytoplasm|extracellular exosome - - - - 19:39196961-39201884 175 169 272 405 431 484 6.25830977451694 5.49271207078899 8.77005202458539 12.9769361526317 12.6463298877423 16.2215976833106 6.84035795663044 13.9482879078949 -1.02794431975768 6.41329905208638e-05 0.000532136269874894 DOWN ENSG00000157064 NMNAT2 nicotinamide nucleotide adenylyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:16789] GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0051186|GO:0006139|GO:0055086|GO:0000166|GO:0044249|GO:0005794|GO:0005768|GO:0005802|GO:0035639|GO:0001883|GO:0032549|GO:0005770|GO:0006796|GO:0000139|GO:0017076|GO:0016779|GO:0006766|GO:0009117|GO:0005524|GO:0030554|GO:0009108|GO:0019752|GO:0009165|GO:0006767|GO:0006531|GO:0043648|GO:0000309|GO:0004515|GO:0019363|GO:0019674|GO:0009435|GO:0034628 synapse|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|endomembrane system|transferase activity|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|nucleotide binding|cellular biosynthetic process|Golgi apparatus|endosome|trans-Golgi network|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|late endosome|phosphate-containing compound metabolic process|Golgi membrane|purine nucleotide binding|nucleotidyltransferase activity|vitamin metabolic process|nucleotide metabolic process|ATP binding|adenyl nucleotide binding|coenzyme biosynthetic process|carboxylic acid metabolic process|nucleotide biosynthetic process|water-soluble vitamin metabolic process|aspartate metabolic process|dicarboxylic acid metabolic process|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity|pyridine nucleotide biosynthetic process|NAD metabolic process|NAD biosynthetic process|'de novo' NAD biosynthetic process from aspartate K06210 nicotinamide mononucleotide adenylyltransferase[2.7.7.18] hsa01100|hsa00760 Metabolic pathways - Homo sapiens (human)|Nicotinate and nicotinamide metabolism - Homo sapiens (human) 1:183248237-183418602 98 127 276 383 358 746 0.911294922264318 1.07329009973704 2.31395755391308 3.19101683590997 2.73139013901176 6.50129768973486 1.43284752530481 4.14123488821886 -1.53117593861553 6.56438516333432e-05 0.00054376568997276 DOWN ENSG00000124216 SNAI1 snail family zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:11128] GO:0040011|GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0051272|GO:0001890|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0010718|GO:0051130|GO:1901360|GO:0060806|GO:0010941|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0060706|GO:0060800|GO:0034641|GO:0044281|GO:0031069|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0022607|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0019899|GO:0001942|GO:0005737|GO:0000981|GO:0007389|GO:0045992|GO:0006928|GO:0009887|GO:1901888|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0009890|GO:0060548|GO:0010646|GO:0006139|GO:0001892|GO:0007154|GO:0001704|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0009968|GO:0001503|GO:0008219|GO:0030656|GO:0045833|GO:0048869|GO:2000145|GO:0044249|GO:0031324|GO:0031323|GO:0003272|GO:0060021|GO:0000982|GO:0043518|GO:0000902|GO:1902230|GO:0003677|GO:0010468|GO:0060536|GO:0034645|GO:0045216|GO:0051216|GO:0046872|GO:0007166|GO:2000736|GO:0002009|GO:0061458|GO:0072358|GO:0010629|GO:0061314|GO:0010720|GO:0007498|GO:0043069|GO:0022405|GO:2001234|GO:0051252|GO:0006066|GO:0010717|GO:0003007|GO:0010957|GO:0000904|GO:0009790|GO:0010628|GO:0030334|GO:0051055|GO:0060707|GO:0007369|GO:0001649|GO:0034329|GO:0003002|GO:2000810|GO:0001707|GO:0060485|GO:2001020|GO:0045939|GO:0022604|GO:0003198|GO:0043588|GO:0008202|GO:0019900|GO:0012501|GO:0003197|GO:0060429|GO:0035556|GO:0048864|GO:0010467|GO:0008610|GO:0019216|GO:0001227|GO:1902532|GO:0046890|GO:0031328|GO:0010770|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0030335|GO:1902531|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0043067|GO:0006974|GO:0048332|GO:0097190|GO:0045995|GO:2000738|GO:0042633|GO:0006766|GO:0000975|GO:0045893|GO:0048863|GO:0097193|GO:2001242|GO:0060317|GO:0009792|GO:1901797|GO:0001078|GO:0010769|GO:0045892|GO:0072331|GO:0042770|GO:0042359|GO:0032774|GO:0043565|GO:0019218|GO:2001141|GO:2001243|GO:0014031|GO:1902679|GO:0008544|GO:0003690|GO:0006694|GO:0008630|GO:0050810|GO:1901796|GO:0048730|GO:0042981|GO:0010894|GO:0043066|GO:0048762|GO:0060972|GO:0007219|GO:0001837|GO:0007043|GO:0006351|GO:0003203|GO:0006915|GO:0006355|GO:0043516|GO:0098773|GO:0070830|GO:0006366|GO:1903507|GO:0043297|GO:0006357|GO:1903506|GO:0044212|GO:0043009|GO:0000122|GO:0030330|GO:0000976|GO:0001012|GO:0001701|GO:0000977 locomotion|developmental process|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|positive regulation of cellular component movement|placenta development|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|positive regulation of epithelial to mesenchymal transition|positive regulation of cellular component organization|organic cyclic compound metabolic process|negative regulation of cell differentiation involved in embryonic placenta development|regulation of cell death|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cell differentiation involved in embryonic placenta development|regulation of cell differentiation involved in embryonic placenta development|cellular nitrogen compound metabolic process|small molecule metabolic process|hair follicle morphogenesis|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|enzyme binding|hair follicle development|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|negative regulation of embryonic development|movement of cell or subcellular component|organ morphogenesis|regulation of cell junction assembly|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|cell communication|formation of primary germ layer|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|negative regulation of signal transduction|ossification|cell death|regulation of vitamin metabolic process|negative regulation of lipid metabolic process|cellular developmental process|regulation of cell motility|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endocardial cushion formation|palate development|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of DNA damage response, signal transduction by p53 class mediator|cell morphogenesis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|DNA binding|regulation of gene expression|cartilage morphogenesis|cellular macromolecule biosynthetic process|cell-cell junction organization|cartilage development|metal ion binding|cell surface receptor signaling pathway|regulation of stem cell differentiation|morphogenesis of an epithelium|reproductive system development|cardiovascular system development|negative regulation of gene expression|Notch signaling involved in heart development|positive regulation of cell development|mesoderm development|negative regulation of programmed cell death|hair cycle process|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|alcohol metabolic process|regulation of epithelial to mesenchymal transition|heart morphogenesis|negative regulation of vitamin D biosynthetic process|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|regulation of cell migration|negative regulation of lipid biosynthetic process|trophoblast giant cell differentiation|gastrulation|osteoblast differentiation|cell junction assembly|regionalization|regulation of bicellular tight junction assembly|mesoderm formation|mesenchyme development|regulation of response to DNA damage stimulus|negative regulation of steroid metabolic process|regulation of cell morphogenesis|epithelial to mesenchymal transition involved in endocardial cushion formation|skin development|steroid metabolic process|kinase binding|programmed cell death|endocardial cushion development|epithelium development|intracellular signal transduction|stem cell development|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|negative regulation of intracellular signal transduction|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|positive regulation of cell morphogenesis involved in differentiation|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|positive regulation of cell migration|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|mesoderm morphogenesis|apoptotic signaling pathway|regulation of embryonic development|positive regulation of stem cell differentiation|hair cycle|vitamin metabolic process|regulatory region DNA binding|positive regulation of transcription, DNA-templated|stem cell differentiation|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|cardiac epithelial to mesenchymal transition|embryo development ending in birth or egg hatching|negative regulation of signal transduction by p53 class mediator|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of cell morphogenesis involved in differentiation|negative regulation of transcription, DNA-templated|signal transduction by p53 class mediator|signal transduction in response to DNA damage|vitamin D metabolic process|RNA biosynthetic process|sequence-specific DNA binding|regulation of steroid metabolic process|regulation of RNA biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway|mesenchymal cell development|negative regulation of RNA biosynthetic process|epidermis development|double-stranded DNA binding|steroid biosynthetic process|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of steroid biosynthetic process|regulation of signal transduction by p53 class mediator|epidermis morphogenesis|regulation of apoptotic process|negative regulation of steroid biosynthetic process|negative regulation of apoptotic process|mesenchymal cell differentiation|left/right pattern formation|Notch signaling pathway|epithelial to mesenchymal transition|cell-cell junction assembly|transcription, DNA-templated|endocardial cushion morphogenesis|apoptotic process|regulation of transcription, DNA-templated|regulation of DNA damage response, signal transduction by p53 class mediator|skin epidermis development|bicellular tight junction assembly|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|apical junction assembly|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|DNA damage response, signal transduction by p53 class mediator|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|RNA polymerase II regulatory region sequence-specific DNA binding K05707 snail 1[-] hsa04520 Adherens junction - Homo sapiens (human) 20:49982999-49988886 158 109 225 68 78 84 6.62896383950253 4.15619593788638 8.51108812770758 2.55620981070028 2.68502706151587 3.3029109010868 6.43208263503216 2.84804925776765 1.17531184308897 6.56958174461923e-05 0.000544045196682004 UP ENSG00000117643 MAN1C1 mannosidase, alpha, class 1C, member 1 [Source:HGNC Symbol;Acc:HGNC:19080] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0006486|GO:0031228|GO:0016798|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0005783|GO:0070062|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0005794|GO:0009311|GO:0034645|GO:0046872|GO:0043412|GO:0006487|GO:0030173|GO:0009100|GO:0036211|GO:0070085|GO:0004553|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0006491|GO:0018279|GO:0005509|GO:0006464|GO:0015923|GO:0018193|GO:0043687|GO:0004559|GO:0004571 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|protein glycosylation|intrinsic component of Golgi membrane|hydrolase activity, acting on glycosyl bonds|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|endoplasmic reticulum|extracellular exosome|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|Golgi apparatus|oligosaccharide metabolic process|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|protein N-linked glycosylation|integral component of Golgi membrane|glycoprotein metabolic process|protein modification process|glycosylation|hydrolase activity, hydrolyzing O-glycosyl compounds|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|N-glycan processing|protein N-linked glycosylation via asparagine|calcium ion binding|cellular protein modification process|mannosidase activity|peptidyl-amino acid modification|post-translational protein modification|alpha-mannosidase activity|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity K01230 mannosyl-oligosaccharide alpha-1,2-mannosidase[3.2.1.113] hsa01100|hsa04141|hsa00510 Metabolic pathways - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) 1:25617468-25786207 2 1 9 20 15 41 0.00982274169534302 0.00446588853887928 0.0398534296482122 0.088012285371799 0.0604499156833556 0.188728519944345 0.0180473532941448 0.112396906999833 -2.63874315363195 6.57489862591088e-05 0.000544334507980986 DOWN ENSG00000170681 MURC muscle-related coiled-coil protein [Source:HGNC Symbol;Acc:HGNC:33742] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009893|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0030017|GO:0030018|GO:0006725|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0061061|GO:0005737|GO:0031674|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010628|GO:0043292|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0007517|GO:0016070|GO:0010557|GO:0045893|GO:0030016|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506 developmental process|cell|cellular process|metabolic process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|positive regulation of metabolic process|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|sarcomere|Z disc|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|cytoplasm|I band|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|positive regulation of gene expression|contractile fiber|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|muscle organ development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|positive regulation of transcription, DNA-templated|myofibril|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 9:100578079-100587906 0 3 1 11 11 10 0 0.0737637976654219 0.0243765498355046 0.266599357387824 0.24413189165706 0.253509740163512 0.0327134491669755 0.254746996402799 -2.96110935219661 6.5822760229988e-05 0.000544643205073742 DOWN ENSG00000242338 BMS1P4 BMS1, ribosome biogenesis factor pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:23652] - - - - - - 10:73715843-73730469 4 4 4 11 20 59 0.129548650088214 0.117742311500127 0.1168096190416 0.319211226908956 0.531475027264949 1.79091236013653 0.12136686020998 0.880532871436812 -2.85900232201931 6.59918551118719e-05 0.000545891061931234 DOWN ENSG00000143355 LHX9 LIM homeobox 9 [Source:HGNC Symbol;Acc:HGNC:14222] GO:0040011|GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0045137|GO:0006935|GO:0003712|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0048608|GO:0043169|GO:0006928|GO:0009887|GO:0007548|GO:0009890|GO:0006139|GO:0008406|GO:0035262|GO:0030030|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0000902|GO:0031175|GO:0003677|GO:0010468|GO:0034645|GO:0008584|GO:0003714|GO:0046872|GO:0008585|GO:0046661|GO:0061458|GO:0010629|GO:0051252|GO:0000904|GO:0046545|GO:0010467|GO:0032990|GO:0007399|GO:0097485|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0005634|GO:0046546|GO:0048666|GO:0030182|GO:0007411|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0061564|GO:0046914|GO:0022008|GO:0048667|GO:0048812|GO:0006351|GO:0006355|GO:1903507|GO:0007409|GO:0008045|GO:0048699|GO:1903506|GO:0008270 locomotion|developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|development of primary sexual characteristics|chemotaxis|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|reproductive structure development|cation binding|movement of cell or subcellular component|organ morphogenesis|sex differentiation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|gonad development|gonad morphogenesis|cell projection organization|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cell morphogenesis|neuron projection development|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gonad development|transcription corepressor activity|metal ion binding|female gonad development|male sex differentiation|reproductive system development|negative regulation of gene expression|regulation of RNA metabolic process|cell morphogenesis involved in differentiation|development of primary female sexual characteristics|gene expression|cell part morphogenesis|nervous system development|neuron projection guidance|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|nucleus|development of primary male sexual characteristics|neuron development|neuron differentiation|axon guidance|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|axon development|transition metal ion binding|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|axonogenesis|motor neuron axon guidance|generation of neurons|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 1:197911902-197935478 52 47 81 21 30 26 0.19491013438699 0.160106698938858 0.273731207124282 0.070525956212246 0.092260557969184 0.0913332413136857 0.209582680150043 0.0847065851650386 1.30697346249345 6.60457469295315e-05 0.000546138940062686 UP ENSG00000168066 SF1 splicing factor 1 [Source:HGNC Symbol;Acc:HGNC:12950] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0000989|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0042802|GO:0045137|GO:0042127|GO:0033327|GO:0007530|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0048608|GO:0043169|GO:0005737|GO:0030529|GO:0007548|GO:0009890|GO:0006139|GO:0008406|GO:0006629|GO:0008285|GO:0048869|GO:0044249|GO:0022613|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:0048660|GO:0008584|GO:0003714|GO:0046872|GO:0003723|GO:0046661|GO:0061458|GO:0051252|GO:0005840|GO:0048659|GO:0030238|GO:0022618|GO:0031981|GO:0005681|GO:0005654|GO:0008202|GO:0010467|GO:0008610|GO:0019216|GO:0046890|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0048662|GO:0046546|GO:0034622|GO:0006396|GO:0032774|GO:0019218|GO:2001141|GO:1902679|GO:0006694|GO:0006376|GO:0016071|GO:0050810|GO:0036002|GO:0046914|GO:0044822|GO:0006351|GO:0000245|GO:0006355|GO:1903507|GO:1903506|GO:0000389|GO:0006397|GO:0045131|GO:0008380|GO:0008270|GO:0000375|GO:0000398 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|identical protein binding|development of primary sexual characteristics|regulation of cell proliferation|Leydig cell differentiation|sex determination|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|reproductive structure development|cation binding|cytoplasm|intracellular ribonucleoprotein complex|sex differentiation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|gonad development|lipid metabolic process|negative regulation of cell proliferation|cellular developmental process|cellular biosynthetic process|ribonucleoprotein complex biogenesis|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|male gonad development|transcription corepressor activity|metal ion binding|RNA binding|male sex differentiation|reproductive system development|regulation of RNA metabolic process|ribosome|smooth muscle cell proliferation|male sex determination|ribonucleoprotein complex assembly|nuclear lumen|spliceosomal complex|nucleoplasm|steroid metabolic process|gene expression|lipid biosynthetic process|regulation of lipid metabolic process|regulation of lipid biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|negative regulation of smooth muscle cell proliferation|development of primary male sexual characteristics|cellular macromolecular complex assembly|RNA processing|RNA biosynthetic process|regulation of steroid metabolic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|steroid biosynthetic process|mRNA splice site selection|mRNA metabolic process|regulation of steroid biosynthetic process|pre-mRNA binding|transition metal ion binding|poly(A) RNA binding|transcription, DNA-templated|spliceosomal complex assembly|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|mRNA 3'-splice site recognition|mRNA processing|pre-mRNA branch point binding|RNA splicing|zinc ion binding|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 11:64764606-64778786 5877 6141 3482 2902 3248 2161 33.0067855905494 31.3448860092695 17.6315551166443 14.6030182452137 14.9668910921374 11.3744722137833 27.3277422388211 13.6481271837115 1.00166327635356 6.67117608032756e-05 0.000551235235820922 UP ENSG00000261096 RP11-690I21.2 - - - - - - - 2:231809846-231812352 13 11 16 0 6 2 0.366800737455363 0.282086456931645 0.407039821279384 0 0.138893099903995 0.05288053081589 0.351975671888797 0.063924543573295 2.46103385541008 6.74949013972697e-05 0.00055678164860848 UP ENSG00000170381 SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E [Source:HGNC Symbol;Acc:HGNC:10727] GO:0040011|GO:0032502|GO:0040007|GO:0045499|GO:0007610|GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0048523|GO:0048521|GO:0050794|GO:0040012|GO:0016049|GO:0050795|GO:0048870|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0040008|GO:0009605|GO:0005615|GO:0050793|GO:0048589|GO:0005515|GO:0048856|GO:0048646|GO:0048514|GO:0051272|GO:0008360|GO:0006935|GO:0045595|GO:0035239|GO:0009888|GO:0048468|GO:0035295|GO:0001568|GO:0007275|GO:0045596|GO:0048513|GO:0032535|GO:0005102|GO:0030155|GO:0051128|GO:2000147|GO:0030308|GO:0007389|GO:0032970|GO:0001763|GO:0050920|GO:0006928|GO:0031589|GO:0048729|GO:0007162|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0048638|GO:0050808|GO:0050922|GO:0051271|GO:0048640|GO:0030030|GO:0048869|GO:0030029|GO:2000145|GO:0001558|GO:0006996|GO:0060560|GO:0050768|GO:0016525|GO:0000902|GO:0031175|GO:0031344|GO:0002040|GO:0007166|GO:0032956|GO:0002009|GO:0001569|GO:0001944|GO:0007010|GO:0072358|GO:0048754|GO:0010721|GO:0061138|GO:0038191|GO:0000904|GO:0050919|GO:0030334|GO:0010812|GO:0001667|GO:0030517|GO:0007160|GO:0031345|GO:0060485|GO:0045765|GO:0008361|GO:0010810|GO:0022604|GO:0030036|GO:0060429|GO:1901342|GO:0033043|GO:0048864|GO:0030516|GO:0032990|GO:0030215|GO:0007399|GO:0060562|GO:0097485|GO:0030154|GO:0048858|GO:0030335|GO:0072359|GO:1902667|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0001755|GO:0048863|GO:0010975|GO:0031532|GO:0010769|GO:0048841|GO:2000249|GO:0014031|GO:0001953|GO:0061564|GO:0051493|GO:0001952|GO:0048762|GO:0045665|GO:0071526|GO:0022008|GO:0048667|GO:0050767|GO:0048843|GO:0048812|GO:0010977|GO:0050771|GO:0048675|GO:0014033|GO:0014032|GO:0007409|GO:0048699|GO:0048846|GO:0050770|GO:0045664 locomotion|developmental process|growth|chemorepellent activity|behavior|signaling|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of cellular process|negative regulation of behavior|regulation of cellular process|regulation of locomotion|cell growth|regulation of behavior|cell motility|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|regulation of growth|response to external stimulus|extracellular space|regulation of developmental process|developmental growth|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|positive regulation of cellular component movement|regulation of cell shape|chemotaxis|regulation of cell differentiation|tube morphogenesis|tissue development|cell development|tube development|blood vessel development|multicellular organism development|negative regulation of cell differentiation|animal organ development|regulation of cellular component size|receptor binding|regulation of cell adhesion|regulation of cellular component organization|positive regulation of cell motility|negative regulation of cell growth|pattern specification process|regulation of actin filament-based process|morphogenesis of a branching structure|regulation of chemotaxis|movement of cell or subcellular component|cell-substrate adhesion|tissue morphogenesis|negative regulation of cell adhesion|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|regulation of developmental growth|synapse organization|negative regulation of chemotaxis|negative regulation of cellular component movement|negative regulation of developmental growth|cell projection organization|cellular developmental process|actin filament-based process|regulation of cell motility|regulation of cell growth|organelle organization|developmental growth involved in morphogenesis|negative regulation of neurogenesis|negative regulation of angiogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|sprouting angiogenesis|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|morphogenesis of an epithelium|patterning of blood vessels|vasculature development|cytoskeleton organization|cardiovascular system development|branching morphogenesis of an epithelial tube|negative regulation of cell development|morphogenesis of a branching epithelium|neuropilin binding|cell morphogenesis involved in differentiation|negative chemotaxis|regulation of cell migration|negative regulation of cell-substrate adhesion|ameboidal-type cell migration|negative regulation of axon extension|cell-matrix adhesion|negative regulation of cell projection organization|mesenchyme development|regulation of angiogenesis|regulation of cell size|regulation of cell-substrate adhesion|regulation of cell morphogenesis|actin cytoskeleton organization|epithelium development|regulation of vasculature development|regulation of organelle organization|stem cell development|regulation of axon extension|cell part morphogenesis|semaphorin receptor binding|nervous system development|epithelial tube morphogenesis|neuron projection guidance|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|circulatory system development|regulation of axon guidance|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|neural crest cell migration|stem cell differentiation|regulation of neuron projection development|actin cytoskeleton reorganization|regulation of cell morphogenesis involved in differentiation|regulation of axon extension involved in axon guidance|regulation of actin cytoskeleton reorganization|mesenchymal cell development|negative regulation of cell-matrix adhesion|axon development|regulation of cytoskeleton organization|regulation of cell-matrix adhesion|mesenchymal cell differentiation|negative regulation of neuron differentiation|semaphorin-plexin signaling pathway|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|negative regulation of axon extension involved in axon guidance|neuron projection morphogenesis|negative regulation of neuron projection development|negative regulation of axonogenesis|axon extension|neural crest cell differentiation|neural crest cell development|axonogenesis|generation of neurons|axon extension involved in axon guidance|regulation of axonogenesis|regulation of neuron differentiation K06840 semaphorin 3[-] hsa04360 Axon guidance - Homo sapiens (human) 7:83363906-83649010 2 5 22 40 46 47 0.0182021520710667 0.0413621892760187 0.180526298967313 0.326192741387203 0.343508240079973 0.400907505565512 0.0800302134381328 0.356869495677563 -2.15677992668329 6.84998238728854e-05 0.000564603462700475 DOWN ENSG00000273142 RP11-458F8.4 - - - - - - - 7:66902857-66906297 49 52 40 110 131 117 1.0072973661239 0.971502385385531 0.741370337551526 2.02604978608068 2.20954025516126 2.25411782728818 0.906723363020319 2.16323595617671 -1.2544566730424 6.85683688697787e-05 0.000565012443896874 DOWN ENSG00000204623 ZNRD1-AS1 ZNRD1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:13924] - - - - - - 6:30001011-30061640 41 50 78 100 172 193 0.113851053358209 0.126182189838795 0.195279679635557 0.248798496743634 0.39187305349327 0.502267831638488 0.145104307610854 0.380979793958464 -1.39262413514279 6.86649377080008e-05 0.000565652055831859 DOWN ENSG00000169570 DTWD2 DTW domain containing 2 [Source:HGNC Symbol;Acc:HGNC:19334] GO:0009987|GO:0050794|GO:0051050|GO:0051641|GO:0016043|GO:1903829|GO:0060341|GO:0006810|GO:0051130|GO:0051128|GO:0032880|GO:0051222|GO:0045184|GO:0032388|GO:0008104|GO:0051649|GO:0090316|GO:0006996|GO:0072594|GO:0007005|GO:0032386|GO:0051223|GO:1903955|GO:0015031|GO:0070201|GO:0046907|GO:0034613|GO:0033043|GO:0006626|GO:1903827|GO:0010638|GO:0033365|GO:0033157|GO:0006839|GO:0006605|GO:0072655|GO:0010822|GO:0016482|GO:0006886|GO:0010821|GO:1903214|GO:1903533|GO:0070585 cellular process|regulation of cellular process|positive regulation of transport|cellular localization|cellular component organization|positive regulation of cellular protein localization|regulation of cellular localization|transport|positive regulation of cellular component organization|regulation of cellular component organization|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|positive regulation of intracellular transport|protein localization|establishment of localization in cell|positive regulation of intracellular protein transport|organelle organization|establishment of protein localization to organelle|mitochondrion organization|regulation of intracellular transport|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|regulation of establishment of protein localization|intracellular transport|cellular protein localization|regulation of organelle organization|protein targeting to mitochondrion|regulation of cellular protein localization|positive regulation of organelle organization|protein localization to organelle|regulation of intracellular protein transport|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|regulation of protein targeting to mitochondrion|regulation of protein targeting|protein localization to mitochondrion - - - - 5:118837322-118988545 30 33 49 84 104 95 0.293956662888745 0.293878846553146 0.432888824672164 0.737470461883638 0.836121375269519 0.872409128014634 0.340241444704685 0.81533365505593 -1.26083168136482 6.8737968090485e-05 0.000566097461896094 DOWN ENSG00000183049 CAMK1D calcium/calmodulin dependent protein kinase ID [Source:HGNC Symbol;Acc:HGNC:19341] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0048520|GO:0071704|GO:0050900|GO:0043167|GO:0044237|GO:0050795|GO:0048870|GO:0040017|GO:0016043|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0051272|GO:0006935|GO:0045595|GO:0006725|GO:0002685|GO:0048468|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0007275|GO:0060263|GO:0060627|GO:0016358|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0010942|GO:0045807|GO:0045597|GO:0043231|GO:0045730|GO:0005737|GO:0050920|GO:0006928|GO:0002687|GO:0060548|GO:0006139|GO:0005516|GO:0051270|GO:0016477|GO:0008219|GO:0030595|GO:0000166|GO:0030030|GO:0048869|GO:2000145|GO:0044249|GO:0019538|GO:0031323|GO:0050921|GO:0051090|GO:0060267|GO:0016192|GO:0006909|GO:0031175|GO:0031344|GO:0010468|GO:0034645|GO:0002688|GO:0035639|GO:0043412|GO:0050773|GO:0010720|GO:0043069|GO:0002690|GO:0051252|GO:0001883|GO:0031346|GO:0010628|GO:0030334|GO:0036211|GO:0006954|GO:0032549|GO:0051091|GO:0060326|GO:0050769|GO:1902622|GO:0030100|GO:0050766|GO:0016301|GO:0012501|GO:0006796|GO:0044267|GO:0010467|GO:0007399|GO:0017076|GO:0031328|GO:0009059|GO:0030154|GO:0030335|GO:0043068|GO:0016070|GO:0016773|GO:0010557|GO:0005634|GO:0043067|GO:0051960|GO:0071621|GO:0048666|GO:0030182|GO:0090023|GO:0045893|GO:0010975|GO:1990266|GO:0043065|GO:0050764|GO:0032774|GO:0005524|GO:2001141|GO:0071622|GO:0030554|GO:0016310|GO:0030593|GO:0071624|GO:0032793|GO:0042981|GO:0043066|GO:0004672|GO:0006897|GO:0022008|GO:0006464|GO:0050767|GO:0010976|GO:0006351|GO:0090022|GO:0006915|GO:0006355|GO:0045666|GO:0006468|GO:0048699|GO:1903506|GO:0004674|GO:0045664|GO:0004683 locomotion|developmental process|immune system process|behavior|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|positive regulation of behavior|organic substance metabolic process|leukocyte migration|ion binding|cellular metabolic process|regulation of behavior|cell motility|positive regulation of locomotion|cellular component organization|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|positive regulation of cellular component movement|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|regulation of leukocyte migration|cell development|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|regulation of respiratory burst|regulation of vesicle-mediated transport|dendrite development|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|positive regulation of cell death|positive regulation of endocytosis|positive regulation of cell differentiation|intracellular membrane-bounded organelle|respiratory burst|cytoplasm|regulation of chemotaxis|movement of cell or subcellular component|positive regulation of leukocyte migration|negative regulation of cell death|nucleobase-containing compound metabolic process|calmodulin binding|regulation of cellular component movement|cell migration|cell death|leukocyte chemotaxis|nucleotide binding|cell projection organization|cellular developmental process|regulation of cell motility|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|positive regulation of chemotaxis|regulation of sequence-specific DNA binding transcription factor activity|positive regulation of respiratory burst|vesicle-mediated transport|phagocytosis|neuron projection development|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of leukocyte chemotaxis|purine ribonucleoside triphosphate binding|macromolecule modification|regulation of dendrite development|positive regulation of cell development|negative regulation of programmed cell death|positive regulation of leukocyte chemotaxis|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of cell projection organization|positive regulation of gene expression|regulation of cell migration|protein modification process|inflammatory response|ribonucleoside binding|positive regulation of sequence-specific DNA binding transcription factor activity|cell chemotaxis|positive regulation of neurogenesis|regulation of neutrophil migration|regulation of endocytosis|positive regulation of phagocytosis|kinase activity|programmed cell death|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|nervous system development|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of cell migration|positive regulation of programmed cell death|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|regulation of nervous system development|granulocyte chemotaxis|neuron development|neuron differentiation|positive regulation of neutrophil chemotaxis|positive regulation of transcription, DNA-templated|regulation of neuron projection development|neutrophil migration|positive regulation of apoptotic process|regulation of phagocytosis|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|regulation of granulocyte chemotaxis|adenyl nucleotide binding|phosphorylation|neutrophil chemotaxis|positive regulation of granulocyte chemotaxis|positive regulation of CREB transcription factor activity|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|endocytosis|neurogenesis|cellular protein modification process|regulation of neurogenesis|positive regulation of neuron projection development|transcription, DNA-templated|regulation of neutrophil chemotaxis|apoptotic process|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|protein serine/threonine kinase activity|regulation of neuron differentiation|calmodulin-dependent protein kinase activity K08794 calcium/calmodulin-dependent protein kinase I[2.7.11.17] hsa04921|hsa04925 Oxytocin signaling pathway - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human) 10:12349482-12835545 45 36 153 218 228 459 0.307256369212324 0.223392169386728 0.9418733915308 1.3336464325102 1.27728957500356 2.93715878695891 0.490840643376617 1.84936493149089 -1.91370331755152 6.90323954764479e-05 0.000568365453544918 DOWN ENSG00000136875 PRPF4 pre-mRNA processing factor 4 [Source:HGNC Symbol;Acc:HGNC:17349] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0003723|GO:0030532|GO:0031981|GO:0005681|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0097525|GO:0017069|GO:0006396|GO:0016604|GO:0016071|GO:0016607|GO:0030621|GO:0071001|GO:0015030|GO:0006397|GO:0097526|GO:0008380|GO:0017070|GO:0000375|GO:0046540|GO:0000398 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|RNA binding|small nuclear ribonucleoprotein complex|nuclear lumen|spliceosomal complex|nucleoplasm|gene expression|RNA metabolic process|nucleus|spliceosomal snRNP complex|snRNA binding|RNA processing|nuclear body|mRNA metabolic process|nuclear speck|U4 snRNA binding|U4/U6 snRNP|Cajal body|mRNA processing|spliceosomal tri-snRNP complex|RNA splicing|U6 snRNA binding|RNA splicing, via transesterification reactions|U4/U6 x U5 tri-snRNP complex|mRNA splicing, via spliceosome K12662 U4/U6 small nuclear ribonucleoprotein PRP4[-] hsa03040 Spliceosome - Homo sapiens (human) 9:113275343-113292905 1931 2100 1368 1015 1222 596 25.2996551164153 25.0052818881262 16.1596787715275 11.9150615735939 13.1362537798094 7.31825160541732 22.1548719253563 10.7898556529402 1.03794842227068 6.91864261048163e-05 0.000569319615472212 UP ENSG00000188452 CERKL ceramide kinase like [Source:HGNC Symbol;Acc:HGNC:21699] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0048523|GO:0050794|GO:0043229|GO:0044237|GO:0043227|GO:0005622|GO:0012505|GO:0016740|GO:0010941|GO:0016772|GO:0043231|GO:0005737|GO:0060548|GO:0005783|GO:0008219|GO:0005794|GO:0005730|GO:0043069|GO:0031981|GO:0016301|GO:0012501|GO:0006796|GO:0005634|GO:0043067|GO:0016310|GO:0042981|GO:0043066|GO:0006915 cell|cellular process|metabolic process|catalytic activity|negative regulation of cellular process|regulation of cellular process|intracellular organelle|cellular metabolic process|membrane-bounded organelle|intracellular|endomembrane system|transferase activity|regulation of cell death|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|negative regulation of cell death|endoplasmic reticulum|cell death|Golgi apparatus|nucleolus|negative regulation of programmed cell death|nuclear lumen|kinase activity|programmed cell death|phosphate-containing compound metabolic process|nucleus|regulation of programmed cell death|phosphorylation|regulation of apoptotic process|negative regulation of apoptotic process|apoptotic process - - - - 2:181536676-181680665 1 4 4 13 15 20 0.00978927838188046 0.0355718921450101 0.0352901103868936 0.113974135396712 0.120431551483149 0.183407932086757 0.0268837603045947 0.139271206322206 -2.37309016722214 6.91736253798173e-05 0.000569319615472212 DOWN ENSG00000057657 PRDM1 PR domain containing 1, with ZNF domain [Source:HGNC Symbol;Acc:HGNC:9346] GO:0032502|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0003824|GO:0051716|GO:0032259|GO:0002683|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0003006|GO:0023051|GO:0009653|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0016740|GO:0048856|GO:0048609|GO:0019222|GO:0048514|GO:0007507|GO:0001893|GO:0042127|GO:1903706|GO:0048565|GO:0001890|GO:0009791|GO:0045595|GO:0006725|GO:0070661|GO:0009888|GO:0048468|GO:0050867|GO:0035295|GO:1901360|GO:0001568|GO:1990654|GO:0007275|GO:0003676|GO:0048513|GO:0031664|GO:0060706|GO:0034641|GO:0046483|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0019899|GO:0005737|GO:0000981|GO:0001763|GO:0003170|GO:0007423|GO:0009887|GO:0002696|GO:0001775|GO:0009966|GO:0048568|GO:0009890|GO:0060135|GO:0010646|GO:0006139|GO:0001892|GO:0009617|GO:0046649|GO:0050865|GO:0007154|GO:0007565|GO:0007276|GO:0007165|GO:0009968|GO:0003279|GO:0002695|GO:0008285|GO:0048869|GO:0031665|GO:0044249|GO:0010033|GO:0031324|GO:0007281|GO:0031323|GO:0003205|GO:0060575|GO:0000982|GO:0051249|GO:0003677|GO:0008168|GO:0042113|GO:0010468|GO:0034645|GO:0032943|GO:0055123|GO:0046872|GO:0007166|GO:0001654|GO:0033993|GO:0001944|GO:0061458|GO:0030097|GO:0072358|GO:0030098|GO:0010629|GO:0002237|GO:0060976|GO:0002064|GO:0051252|GO:0009790|GO:0010628|GO:0060707|GO:0060840|GO:0048844|GO:0071219|GO:0051251|GO:0051250|GO:0003231|GO:0042826|GO:0070664|GO:0060429|GO:0010467|GO:0007399|GO:0071310|GO:0001227|GO:0046651|GO:0009059|GO:0030154|GO:0003281|GO:0016070|GO:0072359|GO:0032496|GO:0005634|GO:0045165|GO:0048666|GO:0030182|GO:0042461|GO:0002521|GO:0000975|GO:0009792|GO:0001078|GO:0030855|GO:0030183|GO:0050869|GO:0045892|GO:0032774|GO:0002066|GO:0043565|GO:2001141|GO:0045619|GO:1902679|GO:0050871|GO:0003690|GO:0050864|GO:0035904|GO:0042100|GO:0032945|GO:0022008|GO:0060576|GO:0071396|GO:0045621|GO:0050672|GO:0006351|GO:0006355|GO:0048592|GO:0071222|GO:0031663|GO:0045577|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0001754|GO:0042462|GO:0043009|GO:0030889|GO:0030888|GO:0000122|GO:0045579|GO:0000976|GO:0001012|GO:0001701|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|reproduction|immune system process|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|catalytic activity|cellular response to stimulus|methylation|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|transferase activity|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|blood vessel morphogenesis|heart development|maternal placenta development|regulation of cell proliferation|regulation of hemopoiesis|digestive tract development|placenta development|post-embryonic development|regulation of cell differentiation|cellular aromatic compound metabolic process|leukocyte proliferation|tissue development|cell development|positive regulation of cell activation|tube development|organic cyclic compound metabolic process|blood vessel development|sebum secreting cell proliferation|multicellular organism development|nucleic acid binding|animal organ development|regulation of lipopolysaccharide-mediated signaling pathway|cell differentiation involved in embryonic placenta development|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|enzyme binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|morphogenesis of a branching structure|heart valve development|sensory organ development|organ morphogenesis|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|embryonic organ development|negative regulation of biosynthetic process|maternal process involved in female pregnancy|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|response to bacterium|lymphocyte activation|regulation of cell activation|cell communication|female pregnancy|gamete generation|signal transduction|negative regulation of signal transduction|cardiac septum development|negative regulation of leukocyte activation|negative regulation of cell proliferation|cellular developmental process|negative regulation of lipopolysaccharide-mediated signaling pathway|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|germ cell development|regulation of cellular metabolic process|cardiac chamber development|intestinal epithelial cell differentiation|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of lymphocyte activation|DNA binding|methyltransferase activity|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|mononuclear cell proliferation|digestive system development|metal ion binding|cell surface receptor signaling pathway|eye development|response to lipid|vasculature development|reproductive system development|hemopoiesis|cardiovascular system development|lymphocyte differentiation|negative regulation of gene expression|response to molecule of bacterial origin|coronary vasculature development|epithelial cell development|regulation of RNA metabolic process|embryo development|positive regulation of gene expression|trophoblast giant cell differentiation|artery development|artery morphogenesis|cellular response to molecule of bacterial origin|positive regulation of lymphocyte activation|negative regulation of lymphocyte activation|cardiac ventricle development|histone deacetylase binding|negative regulation of leukocyte proliferation|epithelium development|gene expression|nervous system development|cellular response to organic substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|ventricular septum development|RNA metabolic process|circulatory system development|response to lipopolysaccharide|nucleus|cell fate commitment|neuron development|neuron differentiation|photoreceptor cell development|leukocyte differentiation|regulatory region DNA binding|embryo development ending in birth or egg hatching|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|epithelial cell differentiation|B cell differentiation|negative regulation of B cell activation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|columnar/cuboidal epithelial cell development|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of lymphocyte differentiation|negative regulation of RNA biosynthetic process|positive regulation of B cell activation|double-stranded DNA binding|regulation of B cell activation|aorta development|B cell proliferation|negative regulation of mononuclear cell proliferation|neurogenesis|intestinal epithelial cell development|cellular response to lipid|positive regulation of lymphocyte differentiation|negative regulation of lymphocyte proliferation|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|cellular response to lipopolysaccharide|lipopolysaccharide-mediated signaling pathway|regulation of B cell differentiation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|eye photoreceptor cell differentiation|eye photoreceptor cell development|chordate embryonic development|negative regulation of B cell proliferation|regulation of B cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of B cell differentiation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 6:106086320-106109939 40 51 117 28 25 18 0.19528435639619 0.226287723838113 0.51500208521852 0.122479105168012 0.10014088996967 0.0823579577817468 0.312191388484274 0.10165931763981 1.61868829019502 6.94886689151722e-05 0.000571491658896295 UP ENSG00000112033 PPARD peroxisome proliferator-activated receptor delta [Source:HGNC Symbol;Acc:HGNC:9235] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0036094|GO:0051716|GO:0040013|GO:0097159|GO:0004872|GO:0009892|GO:0014823|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0008144|GO:0009628|GO:0044237|GO:0051641|GO:0038023|GO:0003006|GO:0048870|GO:0023051|GO:0000989|GO:0045926|GO:0000785|GO:0016043|GO:0051707|GO:0045927|GO:0007155|GO:0043227|GO:0008289|GO:0040008|GO:0009607|GO:0009605|GO:0004879|GO:0009893|GO:0032504|GO:0009058|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0098531|GO:0007507|GO:0060341|GO:0001893|GO:0008284|GO:0046697|GO:0042127|GO:0044255|GO:0001890|GO:0045595|GO:0003712|GO:0006725|GO:0005504|GO:0003707|GO:0046887|GO:0009888|GO:0045684|GO:0006810|GO:1901360|GO:0010941|GO:0006082|GO:0009991|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0043168|GO:0051450|GO:0044281|GO:0032940|GO:0006952|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0042246|GO:0033554|GO:0007566|GO:0044252|GO:0061061|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0030308|GO:0000981|GO:0007267|GO:0009611|GO:0032880|GO:0005975|GO:0051222|GO:0006928|GO:0043177|GO:0031589|GO:0009966|GO:0046983|GO:0050673|GO:1903524|GO:0045184|GO:0009890|GO:0046883|GO:0048639|GO:0060135|GO:0060548|GO:0044236|GO:0010646|GO:0006139|GO:0009617|GO:0000790|GO:0008104|GO:0007154|GO:0007565|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0048638|GO:0008134|GO:0009725|GO:0008219|GO:0051271|GO:0008285|GO:0001666|GO:0051047|GO:0006091|GO:0010817|GO:0048869|GO:2000145|GO:0009967|GO:0044249|GO:0010876|GO:0019538|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0003013|GO:0055114|GO:0007584|GO:0003713|GO:1902533|GO:0003677|GO:0009743|GO:0045682|GO:0044259|GO:0035150|GO:0010468|GO:0090132|GO:0008654|GO:0034645|GO:0048660|GO:0046872|GO:0010712|GO:0090276|GO:0033993|GO:0002793|GO:0061458|GO:0072358|GO:0032964|GO:0010629|GO:0050727|GO:0002237|GO:0016042|GO:0042692|GO:0043069|GO:0046982|GO:0006720|GO:0051252|GO:0006066|GO:0044242|GO:0006631|GO:0051223|GO:0015031|GO:0048659|GO:0010628|GO:0030334|GO:0051147|GO:0001667|GO:0009100|GO:2000291|GO:0071456|GO:0070201|GO:0034440|GO:0042060|GO:0071219|GO:0042886|GO:0006811|GO:0006954|GO:0050714|GO:0033273|GO:0051046|GO:0031981|GO:0045600|GO:0050728|GO:0006869|GO:0009914|GO:0009306|GO:0005996|GO:0005654|GO:0050678|GO:0043403|GO:0005694|GO:0000228|GO:0051059|GO:0050680|GO:0071453|GO:0030336|GO:0008202|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0031406|GO:0010467|GO:0008610|GO:0007399|GO:0046903|GO:0071310|GO:0001227|GO:0045598|GO:0031328|GO:0036041|GO:0009059|GO:0030154|GO:0009755|GO:0061448|GO:0030258|GO:1902531|GO:0043415|GO:0016070|GO:0008643|GO:0072359|GO:0031667|GO:0043616|GO:0008015|GO:0032870|GO:0010557|GO:0032496|GO:0045909|GO:0005634|GO:0051148|GO:0043067|GO:0048662|GO:0090303|GO:0006644|GO:0048545|GO:0030522|GO:0060612|GO:0097190|GO:2000288|GO:0008366|GO:0090277|GO:0006766|GO:0050796|GO:0043401|GO:0002790|GO:0032966|GO:0019318|GO:0045893|GO:0030073|GO:0006820|GO:0015711|GO:0045444|GO:0045445|GO:0042312|GO:0045892|GO:0014068|GO:0032774|GO:0043565|GO:0014909|GO:2001141|GO:0034284|GO:0046395|GO:0050708|GO:0070539|GO:0015833|GO:0014910|GO:1902679|GO:0015908|GO:0008544|GO:0071383|GO:0071407|GO:0045661|GO:0046942|GO:0048017|GO:0014856|GO:0032024|GO:0016125|GO:0010631|GO:0042981|GO:0006029|GO:0046914|GO:0043066|GO:0019752|GO:0014066|GO:0014842|GO:0014912|GO:0009062|GO:0033189|GO:0071396|GO:0019395|GO:0046879|GO:0045662|GO:0006351|GO:0006915|GO:0006355|GO:0032963|GO:0071222|GO:0050880|GO:0061041|GO:0036294|GO:0051546|GO:0014841|GO:0015718|GO:0009299|GO:0006366|GO:0030072|GO:0006635|GO:1903507|GO:0048015|GO:0008645|GO:0006352|GO:0006357|GO:0006776|GO:1903506|GO:0006006|GO:0042311|GO:0008203|GO:0016101|GO:0032787|GO:0000122|GO:0008270|GO:0006367|GO:0001523|GO:0015758|GO:0009749|GO:0014065|GO:1902894 locomotion|developmental process|growth|macromolecular complex|signal transducer activity|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|small molecule binding|cellular response to stimulus|negative regulation of locomotion|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|response to activity|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|drug binding|response to abiotic stimulus|cellular metabolic process|cellular localization|signaling receptor activity|developmental process involved in reproduction|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|negative regulation of growth|chromatin|cellular component organization|response to other organism|positive regulation of growth|cell adhesion|membrane-bounded organelle|lipid binding|regulation of growth|response to biotic stimulus|response to external stimulus|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|regulation of developmental process|developmental growth|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|heart development|regulation of cellular localization|maternal placenta development|positive regulation of cell proliferation|decidualization|regulation of cell proliferation|cellular lipid metabolic process|placenta development|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|fatty acid binding|steroid hormone receptor activity|positive regulation of hormone secretion|tissue development|positive regulation of epidermis development|transport|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|anion binding|myoblast proliferation|small molecule metabolic process|secretion by cell|defense response|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|tissue regeneration|cellular response to stress|embryo implantation|negative regulation of multicellular organismal metabolic process|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|negative regulation of cell growth|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cell-cell signaling|response to wounding|regulation of protein localization|carbohydrate metabolic process|positive regulation of protein transport|movement of cell or subcellular component|organic acid binding|cell-substrate adhesion|regulation of signal transduction|protein dimerization activity|epithelial cell proliferation|positive regulation of blood circulation|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|positive regulation of developmental growth|maternal process involved in female pregnancy|negative regulation of cell death|multicellular organism metabolic process|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|nuclear chromatin|protein localization|cell communication|female pregnancy|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|regulation of developmental growth|transcription factor binding|response to hormone|cell death|negative regulation of cellular component movement|negative regulation of cell proliferation|response to hypoxia|positive regulation of secretion|generation of precursor metabolites and energy|regulation of hormone levels|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|protein metabolic process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|circulatory system process|oxidation-reduction process|response to nutrient|transcription coactivator activity|positive regulation of intracellular signal transduction|DNA binding|response to carbohydrate|regulation of epidermis development|multicellular organismal macromolecule metabolic process|regulation of tube size|regulation of gene expression|epithelium migration|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|metal ion binding|regulation of collagen metabolic process|regulation of peptide hormone secretion|response to lipid|positive regulation of peptide secretion|reproductive system development|cardiovascular system development|collagen biosynthetic process|negative regulation of gene expression|regulation of inflammatory response|response to molecule of bacterial origin|lipid catabolic process|muscle cell differentiation|negative regulation of programmed cell death|protein heterodimerization activity|isoprenoid metabolic process|regulation of RNA metabolic process|alcohol metabolic process|cellular lipid catabolic process|fatty acid metabolic process|regulation of protein transport|protein transport|smooth muscle cell proliferation|positive regulation of gene expression|regulation of cell migration|regulation of muscle cell differentiation|ameboidal-type cell migration|glycoprotein metabolic process|regulation of myoblast proliferation|cellular response to hypoxia|regulation of establishment of protein localization|lipid oxidation|wound healing|cellular response to molecule of bacterial origin|amide transport|ion transport|inflammatory response|positive regulation of protein secretion|response to vitamin|regulation of secretion|nuclear lumen|positive regulation of fat cell differentiation|negative regulation of inflammatory response|lipid transport|hormone transport|protein secretion|monosaccharide metabolic process|nucleoplasm|regulation of epithelial cell proliferation|skeletal muscle tissue regeneration|chromosome|nuclear chromosome|NF-kappaB binding|negative regulation of epithelial cell proliferation|cellular response to oxygen levels|negative regulation of cell migration|steroid metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|carboxylic acid binding|gene expression|lipid biosynthetic process|nervous system development|secretion|cellular response to organic substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|long-chain fatty acid binding|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|connective tissue development|lipid modification|regulation of intracellular signal transduction|positive regulation of skeletal muscle tissue regeneration|RNA metabolic process|carbohydrate transport|circulatory system development|response to nutrient levels|keratinocyte proliferation|blood circulation|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|positive regulation of vasodilation|nucleus|negative regulation of muscle cell differentiation|regulation of programmed cell death|negative regulation of smooth muscle cell proliferation|positive regulation of wound healing|phospholipid metabolic process|response to steroid hormone|intracellular receptor signaling pathway|adipose tissue development|apoptotic signaling pathway|positive regulation of myoblast proliferation|axon ensheathment|positive regulation of peptide hormone secretion|vitamin metabolic process|regulation of insulin secretion|steroid hormone mediated signaling pathway|peptide secretion|negative regulation of collagen biosynthetic process|hexose metabolic process|positive regulation of transcription, DNA-templated|insulin secretion|anion transport|organic anion transport|fat cell differentiation|myoblast differentiation|regulation of vasodilation|negative regulation of transcription, DNA-templated|positive regulation of phosphatidylinositol 3-kinase signaling|RNA biosynthetic process|sequence-specific DNA binding|smooth muscle cell migration|regulation of RNA biosynthetic process|response to monosaccharide|carboxylic acid catabolic process|regulation of protein secretion|linoleic acid binding|peptide transport|regulation of smooth muscle cell migration|negative regulation of RNA biosynthetic process|fatty acid transport|epidermis development|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|regulation of myoblast differentiation|carboxylic acid transport|inositol lipid-mediated signaling|skeletal muscle cell proliferation|positive regulation of insulin secretion|sterol metabolic process|epithelial cell migration|regulation of apoptotic process|proteoglycan metabolic process|transition metal ion binding|negative regulation of apoptotic process|carboxylic acid metabolic process|regulation of phosphatidylinositol 3-kinase signaling|regulation of skeletal muscle satellite cell proliferation|negative regulation of smooth muscle cell migration|fatty acid catabolic process|response to vitamin A|cellular response to lipid|fatty acid oxidation|hormone secretion|negative regulation of myoblast differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|collagen metabolic process|cellular response to lipopolysaccharide|regulation of blood vessel size|regulation of wound healing|cellular response to decreased oxygen levels|keratinocyte migration|skeletal muscle satellite cell proliferation|monocarboxylic acid transport|mRNA transcription|transcription from RNA polymerase II promoter|peptide hormone secretion|fatty acid beta-oxidation|negative regulation of nucleic acid-templated transcription|phosphatidylinositol-mediated signaling|hexose transport|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|vitamin A metabolic process|regulation of nucleic acid-templated transcription|glucose metabolic process|vasodilation|cholesterol metabolic process|diterpenoid metabolic process|monocarboxylic acid metabolic process|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|transcription initiation from RNA polymerase II promoter|retinoid metabolic process|glucose transport|response to glucose|phosphatidylinositol 3-kinase signaling|negative regulation of pri-miRNA transcription from RNA polymerase II promoter K04504 peroxisome proliferator-activated receptor delta[-] hsa05200|hsa04310|hsa03320|hsa05221 Pathways in cancer - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human) 6:35342558-35428191 228 207 550 762 856 755 2.20237351121392 1.81721998566506 4.78997598269017 6.5949210338805 6.7841971916495 6.8349056057576 2.93652315985638 6.73800794376253 -1.19821311315396 6.99824979365777e-05 0.000574761346189433 DOWN ENSG00000135374 ELF5 E74-like factor 5 (ets domain transcription factor) [Source:HGNC Symbol;Acc:HGNC:3320] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0045595|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0048598|GO:0006139|GO:0001704|GO:0048869|GO:0044249|GO:0019827|GO:0031323|GO:0048732|GO:0003677|GO:0030879|GO:0010468|GO:0034645|GO:0051252|GO:0060795|GO:0007398|GO:0009790|GO:0010628|GO:0001705|GO:0007369|GO:0035019|GO:0060429|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0045165|GO:0000975|GO:0045893|GO:0030855|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0010668|GO:0061180|GO:0006351|GO:0001712|GO:0006355|GO:0060644|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|embryonic morphogenesis|nucleobase-containing compound metabolic process|formation of primary germ layer|cellular developmental process|cellular biosynthetic process|stem cell population maintenance|regulation of cellular metabolic process|gland development|DNA binding|mammary gland development|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|cell fate commitment involved in formation of primary germ layer|ectoderm development|embryo development|positive regulation of gene expression|ectoderm formation|gastrulation|somatic stem cell population maintenance|epithelium development|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|cell fate commitment|regulatory region DNA binding|positive regulation of transcription, DNA-templated|epithelial cell differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|ectodermal cell differentiation|mammary gland epithelium development|transcription, DNA-templated|ectodermal cell fate commitment|regulation of transcription, DNA-templated|mammary gland epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding K17101 E74-like factor 5[-] hsa04917 Prolactin signaling pathway - Homo sapiens (human) 11:34478793-34513805 26 26 64 97 99 177 0.218347251288281 0.198441155651883 0.484585282094526 0.729872763756477 0.682151289664818 1.39309720807486 0.300457896344897 0.935040420498718 -1.63786589416036 7.10336503075904e-05 0.000582273090687206 DOWN ENSG00000136710 CCDC115 coiled-coil domain containing 115 [Source:HGNC Symbol;Acc:HGNC:28178] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0005622|GO:0012505|GO:0043231|GO:0005737|GO:0005768|GO:0005773|GO:0000323|GO:0005764 cell|membrane|intracellular organelle|membrane-bounded organelle|intracellular|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endosome|vacuole|lytic vacuole|lysosome - - - - 2:130338241-130342349 923 942 959 613 616 279 8.90845865388609 8.2628870797925 8.34514712491956 5.30101626751845 4.87808540225745 2.52367990355391 8.50549761953272 4.23426052444327 1.0062856063172 7.13657301543103e-05 0.000584674124046866 UP ENSG00000251026 RP11-138J23.1 - - - - - - - 5:104079911-104105403 0 2 1 8 13 8 0 0.223997568219754 0.111053445679172 0.883356830757278 1.3144132935592 0.923965992634402 0.111683671299642 1.04057870565029 -3.21989591222847 7.20876287047763e-05 0.000590426355926582 DOWN ENSG00000133636 NTS neurotensin [Source:HGNC Symbol;Acc:HGNC:8038] GO:0032502|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0043229|GO:0006950|GO:0009628|GO:0044297|GO:0043227|GO:0044708|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0048565|GO:0043025|GO:0009314|GO:0035295|GO:0007275|GO:0048513|GO:0050877|GO:0005102|GO:0031982|GO:0007632|GO:0043231|GO:0030133|GO:0010243|GO:0005737|GO:0009611|GO:1990089|GO:0043005|GO:0036477|GO:0042493|GO:0007154|GO:0007165|GO:0009725|GO:0044306|GO:0007611|GO:0006970|GO:0010035|GO:0010033|GO:0048732|GO:0003013|GO:0035150|GO:0055123|GO:0033993|GO:0030424|GO:1990090|GO:0031410|GO:0007612|GO:0048678|GO:0005179|GO:0001889|GO:0010038|GO:0016023|GO:0043679|GO:0043279|GO:0070848|GO:0031988|GO:0006972|GO:0014070|GO:0060359|GO:0071241|GO:0014075|GO:0071310|GO:0050890|GO:0097332|GO:0008015|GO:0032870|GO:0009416|GO:0042220|GO:0048545|GO:0097305|GO:0008542|GO:0005184|GO:0051412|GO:0008306|GO:0010226|GO:0071363|GO:0043627|GO:0071383|GO:0071407|GO:0001975|GO:0032355|GO:0071396|GO:0031960|GO:0071548|GO:0071248|GO:0050880|GO:0051384|GO:0071285|GO:0071549|GO:0051385|GO:0071384|GO:0071385 developmental process|behavior|signaling|cell|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|intracellular organelle|response to stress|response to abiotic stimulus|cell body|membrane-bounded organelle|single-organism behavior|intracellular|protein binding|endomembrane system|anatomical structure development|digestive tract development|neuronal cell body|response to radiation|tube development|multicellular organism development|animal organ development|neurological system process|receptor binding|vesicle|visual behavior|intracellular membrane-bounded organelle|transport vesicle|response to organonitrogen compound|cytoplasm|response to wounding|response to nerve growth factor|neuron projection|somatodendritic compartment|response to drug|cell communication|signal transduction|response to hormone|neuron projection terminus|learning or memory|response to osmotic stress|response to inorganic substance|response to organic substance|gland development|circulatory system process|regulation of tube size|digestive system development|response to lipid|axon|cellular response to nerve growth factor stimulus|cytoplasmic vesicle|learning|response to axon injury|hormone activity|liver development|response to metal ion|cytoplasmic, membrane-bounded vesicle|axon terminus|response to alkaloid|response to growth factor|membrane-bounded vesicle|hyperosmotic response|response to organic cyclic compound|response to ammonium ion|cellular response to inorganic substance|response to amine|cellular response to organic substance|cognition|response to antipsychotic drug|blood circulation|cellular response to hormone stimulus|response to light stimulus|response to cocaine|response to steroid hormone|response to alcohol|visual learning|neuropeptide hormone activity|response to corticosterone|associative learning|response to lithium ion|cellular response to growth factor stimulus|response to estrogen|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|response to amphetamine|response to estradiol|cellular response to lipid|response to corticosteroid|response to dexamethasone|cellular response to metal ion|regulation of blood vessel size|response to glucocorticoid|cellular response to lithium ion|cellular response to dexamethasone stimulus|response to mineralocorticoid|cellular response to corticosteroid stimulus|cellular response to glucocorticoid stimulus - - - - 12:85874295-85882992 1 1 0 4 11 13 0.0228722344610904 0.0207878884088363 0 0.0819403395046344 0.20633642426736 0.278557118103148 0.0145533742899756 0.188944627291714 -3.69853790081843 7.33107370992768e-05 0.000599621574071729 DOWN ENSG00000116194 ANGPTL1 angiopoietin like 1 [Source:HGNC Symbol;Acc:HGNC:489] GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043227|GO:0005615|GO:0005515|GO:0005102|GO:0031982|GO:0007154|GO:0007165|GO:0070062|GO:0007166|GO:0007167|GO:0007169 signaling|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|membrane-bounded organelle|extracellular space|protein binding|receptor binding|vesicle|cell communication|signal transduction|extracellular exosome|cell surface receptor signaling pathway|enzyme linked receptor protein signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway - - - - 1:178849705-178871052 0 1 0 7 7 7 0 0.0132422743950874 0 0.0913390795021248 0.0836459190948461 0.0955467849278214 0.00441409146502913 0.0901772611749308 -4.35257526439331 7.43443721546654e-05 0.000607244018141007 DOWN ENSG00000188033 ZNF490 zinc finger protein 490 [Source:HGNC Symbol;Acc:HGNC:23705] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:12577961-12640098 88 113 138 18 48 62 1.10900028206558 1.29422689463615 1.56799767156338 0.203240910156953 0.49631469369701 0.732266137657462 1.32374161608837 0.477273913837142 1.47173215607234 7.44403394578031e-05 0.0006076953497876 UP ENSG00000105204 DYRK1B dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B [Source:HGNC Symbol;Acc:HGNC:3092] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0003824|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0048646|GO:0019222|GO:0006949|GO:0003712|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0061061|GO:0043231|GO:0006139|GO:0000166|GO:0048869|GO:0044249|GO:0019538|GO:0031323|GO:0003713|GO:0010468|GO:0034645|GO:0035639|GO:0043412|GO:0042692|GO:0051252|GO:0001883|GO:0010628|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0010467|GO:0017076|GO:0031328|GO:0009059|GO:0030154|GO:0061448|GO:0016070|GO:0016773|GO:0010557|GO:0005634|GO:0060612|GO:0007520|GO:0045893|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0016310|GO:0051146|GO:0004672|GO:0006464|GO:0006351|GO:0006355|GO:0006468|GO:0004712|GO:1903506|GO:0004713|GO:0018193|GO:0014902|GO:0004674|GO:0018108 developmental process|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|catalytic activity|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|syncytium formation|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleotide binding|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|purine ribonucleoside triphosphate binding|macromolecule modification|muscle cell differentiation|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of gene expression|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|connective tissue development|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|nucleus|adipose tissue development|myoblast fusion|positive regulation of transcription, DNA-templated|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|striated muscle cell differentiation|protein kinase activity|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|protein serine/threonine/tyrosine kinase activity|regulation of nucleic acid-templated transcription|protein tyrosine kinase activity|peptidyl-amino acid modification|myotube differentiation|protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation - - - - 19:39825350-39834201 242 235 146 90 95 111 3.07994195121315 2.71816236294336 1.67530201477244 1.02628362360183 0.992015769198852 1.32397165431485 2.49113544297632 1.11409034903851 1.16093722779388 7.52332940361331e-05 0.00061366523501495 UP ENSG00000117407 ARTN artemin [Source:HGNC Symbol;Acc:HGNC:727] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0040012|GO:0048520|GO:0050900|GO:0050795|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0009605|GO:0005615|GO:0002520|GO:0005515|GO:0048856|GO:0006935|GO:0009888|GO:0048468|GO:0007275|GO:0048513|GO:0005102|GO:0050920|GO:0006928|GO:0048729|GO:0007154|GO:0016477|GO:0007165|GO:0061351|GO:0030030|GO:0072676|GO:0048869|GO:0050921|GO:0072089|GO:0000902|GO:0031175|GO:0061146|GO:0007405|GO:0000904|GO:0050927|GO:0048537|GO:0050918|GO:0032990|GO:0007399|GO:0097485|GO:0097021|GO:0030154|GO:0048858|GO:0008083|GO:0007422|GO:0048666|GO:0030182|GO:0007411|GO:0050930|GO:0048541|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699 locomotion|developmental process|immune system process|behavior|signaling|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|positive regulation of behavior|leukocyte migration|regulation of behavior|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to external stimulus|extracellular space|immune system development|protein binding|anatomical structure development|chemotaxis|tissue development|cell development|multicellular organism development|animal organ development|receptor binding|regulation of chemotaxis|movement of cell or subcellular component|tissue morphogenesis|cell communication|cell migration|signal transduction|neural precursor cell proliferation|cell projection organization|lymphocyte migration|cellular developmental process|positive regulation of chemotaxis|stem cell proliferation|cell morphogenesis|neuron projection development|Peyer's patch morphogenesis|neuroblast proliferation|cell morphogenesis involved in differentiation|positive regulation of positive chemotaxis|mucosal-associated lymphoid tissue development|positive chemotaxis|cell part morphogenesis|nervous system development|neuron projection guidance|lymphocyte migration into lymphoid organs|cell differentiation|cell projection morphogenesis|growth factor activity|peripheral nervous system development|neuron development|neuron differentiation|axon guidance|induction of positive chemotaxis|Peyer's patch development|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons - - - - 1:43933320-43937241 129 128 105 61 59 62 1.27676791891439 1.15136066407176 0.936970559503368 0.540936296835988 0.479120944977398 0.57509582071797 1.12169971416317 0.531717687510452 1.07695414602618 7.53825371444813e-05 0.000614714630950927 UP ENSG00000060656 PTPRU protein tyrosine phosphatase, receptor type, U [Source:HGNC Symbol;Acc:HGNC:9683] GO:0040011|GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0040013|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0071704|GO:0044237|GO:0051641|GO:0038023|GO:0048870|GO:0005911|GO:0007155|GO:0071944|GO:0016787|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0042127|GO:0016337|GO:0008013|GO:0007275|GO:0048513|GO:0016788|GO:0098609|GO:0005887|GO:0004888|GO:0006928|GO:0031226|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009725|GO:0051271|GO:0008285|GO:0048869|GO:0016021|GO:2000145|GO:0019538|GO:0010033|GO:2000146|GO:0007166|GO:0033993|GO:0043412|GO:0031100|GO:0034109|GO:0030334|GO:0036211|GO:0030336|GO:0034613|GO:0014070|GO:0006796|GO:0044267|GO:0030154|GO:0042578|GO:0048545|GO:0016055|GO:0016311|GO:0034394|GO:0007167|GO:0016791|GO:0006464|GO:0031960|GO:0005001|GO:0006470|GO:0051384|GO:0060070|GO:0004721|GO:0007185|GO:0035335|GO:0004725 locomotion|developmental process|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of locomotion|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|organic substance metabolic process|cellular metabolic process|cellular localization|signaling receptor activity|cell motility|cell-cell junction|cell adhesion|cell periphery|hydrolase activity|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|regulation of cell proliferation|single organismal cell-cell adhesion|beta-catenin binding|multicellular organism development|animal organ development|hydrolase activity, acting on ester bonds|cell-cell adhesion|integral component of plasma membrane|transmembrane signaling receptor activity|movement of cell or subcellular component|intrinsic component of plasma membrane|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|response to hormone|negative regulation of cellular component movement|negative regulation of cell proliferation|cellular developmental process|integral component of membrane|regulation of cell motility|protein metabolic process|response to organic substance|negative regulation of cell motility|cell surface receptor signaling pathway|response to lipid|macromolecule modification|organ regeneration|homotypic cell-cell adhesion|regulation of cell migration|protein modification process|negative regulation of cell migration|cellular protein localization|response to organic cyclic compound|phosphate-containing compound metabolic process|cellular protein metabolic process|cell differentiation|phosphoric ester hydrolase activity|response to steroid hormone|Wnt signaling pathway|dephosphorylation|protein localization to cell surface|enzyme linked receptor protein signaling pathway|phosphatase activity|cellular protein modification process|response to corticosteroid|transmembrane receptor protein tyrosine phosphatase activity|protein dephosphorylation|response to glucocorticoid|canonical Wnt signaling pathway|phosphoprotein phosphatase activity|transmembrane receptor protein tyrosine phosphatase signaling pathway|peptidyl-tyrosine dephosphorylation|protein tyrosine phosphatase activity - - - - 1:29236516-29326813 305 304 684 866 908 1193 1.88015370317196 1.70312329690955 3.8015732325698 4.7830901027773 4.59247801299862 6.89227338539646 2.4616167442171 5.42261383372413 -1.13938227165395 7.56241312121804e-05 0.000616516333481276 DOWN ENSG00000271141 RP11-171I2.4 - - - - - - - 2:178616581-178617123 3 1 4 8 24 24 0.390854179224575 0.118448852185892 0.469819904211518 0.933787883710272 2.5652601262157 2.93014629708368 0.326374311873995 2.14306476900322 -2.71507603679509 7.64029495432007e-05 0.000622695510691432 DOWN ENSG00000197162 ZNF785 zinc finger protein 785 [Source:HGNC Symbol;Acc:HGNC:26496] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 16:30573740-30585771 75 93 91 153 224 245 0.748800160117646 0.843860200142743 0.819144087624077 1.36865459402674 1.83493651489745 2.29245626016974 0.803934815961489 1.83201578969798 -1.18828150198182 7.66437558907056e-05 0.000624487633286333 DOWN ENSG00000054690 PLEKHH1 pleckstrin homology, MyTH4 and FERM domain containing H1 [Source:HGNC Symbol;Acc:HGNC:17733] GO:0005623|GO:0043229|GO:0005622|GO:0005856 cell|intracellular organelle|intracellular|cytoskeleton - - - - 14:67533301-67589612 39 56 107 149 194 198 0.118034757248065 0.15403426820246 0.291976925071196 0.404050081570433 0.481746703664812 0.561620720094447 0.188015316840574 0.482472501776564 -1.35959652203958 7.66883330128725e-05 0.000624680353005811 DOWN ENSG00000196220 SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:19744] GO:0040011|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0048523|GO:0050794|GO:0040012|GO:0048870|GO:0023051|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0008047|GO:0019899|GO:0005737|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0051271|GO:0050790|GO:2000145|GO:2000146|GO:0005829|GO:0005096|GO:0051345|GO:0030695|GO:0030334|GO:0030336|GO:0035556|GO:0051020|GO:1902531|GO:0043087|GO:0043547|GO:0031267|GO:0051056|GO:0007264|GO:0017016|GO:0017048|GO:0048365 locomotion|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|cell motility|regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|enzyme activator activity|enzyme binding|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of cellular component movement|regulation of catalytic activity|regulation of cell motility|negative regulation of cell motility|cytosol|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|regulation of cell migration|negative regulation of cell migration|intracellular signal transduction|GTPase binding|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase binding|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|Ras GTPase binding|Rho GTPase binding|Rac GTPase binding K07526 SLIT-ROBO Rho GTPase activating protein[-] hsa04360 Axon guidance - Homo sapiens (human) 3:8980591-9363053 18 22 46 80 65 186 0.0460795597139501 0.0511841577062655 0.106171237821912 0.183492901487791 0.136525853908974 0.446247105123205 0.0678116517473759 0.255421953506657 -1.91327743888219 7.67839738772143e-05 0.000625288804181766 DOWN ENSG00000106078 COBL cordon-bleu WH2 repeat protein [Source:HGNC Symbol;Acc:HGNC:22199] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0050794|GO:0043229|GO:0016049|GO:0044089|GO:0044297|GO:0009653|GO:0016043|GO:0030427|GO:0071944|GO:0031252|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0048565|GO:0001756|GO:0045595|GO:0035239|GO:0009888|GO:0048468|GO:0043025|GO:0035295|GO:0051130|GO:0005884|GO:0005938|GO:0007275|GO:0048513|GO:0016358|GO:0051128|GO:0030426|GO:0022607|GO:0045597|GO:0005737|GO:0044292|GO:0007389|GO:0001726|GO:0043005|GO:0021915|GO:0048729|GO:0048598|GO:0048568|GO:0036477|GO:0033504|GO:0035148|GO:0060491|GO:0048588|GO:0008092|GO:0030030|GO:0048869|GO:0030029|GO:1900029|GO:0048732|GO:0006996|GO:0060560|GO:0000902|GO:0031175|GO:0048668|GO:0031344|GO:1900027|GO:0055123|GO:0002009|GO:0030424|GO:0007010|GO:0050773|GO:0010720|GO:0009798|GO:0009880|GO:0003779|GO:0044295|GO:0031346|GO:0000904|GO:0009790|GO:0001889|GO:0072175|GO:0030903|GO:0003002|GO:0016331|GO:0050769|GO:0030031|GO:0030425|GO:0048471|GO:0006461|GO:0044294|GO:0030036|GO:0001841|GO:0060429|GO:0007379|GO:0001757|GO:0032990|GO:0007399|GO:0060562|GO:0031529|GO:0030154|GO:0048858|GO:0060606|GO:1900006|GO:0005856|GO:0051960|GO:0048666|GO:0030182|GO:0015629|GO:0010975|GO:0048669|GO:0000578|GO:0009792|GO:0003785|GO:0034622|GO:0001843|GO:0001838|GO:0043623|GO:0061564|GO:0061053|GO:0009952|GO:0097178|GO:0022008|GO:0048667|GO:0007015|GO:0050767|GO:0048812|GO:0010976|GO:0035282|GO:0045666|GO:0051258|GO:0007409|GO:0048699|GO:0043009|GO:0045664|GO:0051639|GO:0008154|GO:0030041 developmental process|growth|cell|membrane|cellular process|binding|cell projection|regulation of cellular process|intracellular organelle|cell growth|positive regulation of cellular component biogenesis|cell body|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell periphery|cell leading edge|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|digestive tract development|somitogenesis|regulation of cell differentiation|tube morphogenesis|tissue development|cell development|neuronal cell body|tube development|positive regulation of cellular component organization|actin filament|cell cortex|multicellular organism development|animal organ development|dendrite development|regulation of cellular component organization|growth cone|cellular component assembly|positive regulation of cell differentiation|cytoplasm|dendrite terminus|pattern specification process|ruffle|neuron projection|neural tube development|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|somatodendritic compartment|floor plate development|tube formation|regulation of cell projection assembly|developmental cell growth|cytoskeletal protein binding|cell projection organization|cellular developmental process|actin filament-based process|positive regulation of ruffle assembly|gland development|organelle organization|developmental growth involved in morphogenesis|cell morphogenesis|neuron projection development|collateral sprouting|regulation of cell projection organization|regulation of ruffle assembly|digestive system development|morphogenesis of an epithelium|axon|cytoskeleton organization|regulation of dendrite development|positive regulation of cell development|axis specification|embryonic pattern specification|actin binding|axonal growth cone|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|embryo development|liver development|epithelial tube formation|notochord development|regionalization|morphogenesis of embryonic epithelium|positive regulation of neurogenesis|cell projection assembly|dendrite|perinuclear region of cytoplasm|protein complex assembly|dendritic growth cone|actin cytoskeleton organization|neural tube formation|epithelium development|segment specification|somite specification|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|ruffle organization|cell differentiation|cell projection morphogenesis|tube closure|positive regulation of dendrite development|cytoskeleton|regulation of nervous system development|neuron development|neuron differentiation|actin cytoskeleton|regulation of neuron projection development|collateral sprouting in absence of injury|embryonic axis specification|embryo development ending in birth or egg hatching|actin monomer binding|cellular macromolecular complex assembly|neural tube closure|embryonic epithelial tube formation|cellular protein complex assembly|axon development|somite development|anterior/posterior pattern specification|ruffle assembly|neurogenesis|cell morphogenesis involved in neuron differentiation|actin filament organization|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|segmentation|positive regulation of neuron differentiation|protein polymerization|axonogenesis|generation of neurons|chordate embryonic development|regulation of neuron differentiation|actin filament network formation|actin polymerization or depolymerization|actin filament polymerization - - - - 7:51016212-51316818 449 528 1082 1381 1588 1549 1.7567819367817 1.87752399729324 3.81691742103507 4.84130626434972 5.09788109297707 5.68004448008235 2.48374111837 5.20641061246971 -1.06777428829942 7.68483565904427e-05 0.000625642442773678 DOWN ENSG00000265393 CTD-2517M22.17 - - - - - - - 8:144512567-144513672 19 16 19 5 6 4 3.97624504878576 3.04318589723406 3.58505802887777 0.937491727598079 1.03019231200981 0.784446690860569 3.5348296582992 0.917376910156153 1.94605419275259 7.69953407132294e-05 0.000626668184747205 UP ENSG00000268362 CTD-2017D11.1 - - - - - - - 19:24033445-24066909 0 1 0 6 8 7 0 0.0179158013194817 0 0.105929001571311 0.129340238615047 0.129267614037445 0.00597193377316057 0.121512284741268 -4.34676019912467 7.71200469278382e-05 0.000627341111984654 DOWN ENSG00000235703 LINC00894 long intergenic non-protein coding RNA 894 [Source:HGNC Symbol;Acc:HGNC:48579] - - - - - - X:149938628-150224580 9 9 22 29 56 62 0.0637591584384511 0.0579485371426635 0.140515813277312 0.184077382723303 0.325502837491171 0.411638440728226 0.0874078362861422 0.3070728869809 -1.81274660397861 7.7531099888994e-05 0.000630341355143254 DOWN ENSG00000178105 DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 [Source:HGNC Symbol;Acc:HGNC:2735] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0016787|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0016817|GO:0006139|GO:0000166|GO:0003723|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0017076|GO:0016070|GO:0010501|GO:0005524|GO:0030554|GO:0044822|GO:0016462|GO:0017111|GO:0016887|GO:0004386|GO:0042623|GO:0003724|GO:0008026|GO:0004004|GO:0008186 cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|hydrolase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|nucleobase-containing compound metabolic process|nucleotide binding|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|purine nucleotide binding|RNA metabolic process|RNA secondary structure unwinding|ATP binding|adenyl nucleotide binding|poly(A) RNA binding|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|helicase activity|ATPase activity, coupled|RNA helicase activity|ATP-dependent helicase activity|ATP-dependent RNA helicase activity|RNA-dependent ATPase activity - - - - 11:108665025-108940930 191 194 161 494 495 304 1.27112051953279 1.17336876501453 0.966039397142985 2.94563131963342 2.70288059148854 1.89607726012238 1.13684289389677 2.51486305708145 -1.14544694783909 7.786626353752e-05 0.00063272167437374 DOWN ENSG00000261505 LA16c-358B7.3 - - - - - - - 16:1317891-1322845 298 219 212 107 112 146 3.49404867773689 2.33365648598941 2.24110944497507 1.1240720727978 1.07745593646588 1.60432912479756 2.68960486956712 1.26861904468708 1.08413533632223 7.82216763471614e-05 0.000635091086665259 UP ENSG00000226711 FAM66C family with sequence similarity 66 member C [Source:HGNC Symbol;Acc:HGNC:21644] - - - - - - 12:8180209-8216151 8 10 3 25 32 29 0.0793199472365182 0.0901139642263379 0.0268153605008791 0.222103904690895 0.260332153604459 0.269483903308807 0.0654164239879117 0.250639987201387 -1.93789179990099 7.97973776259858e-05 0.000647143965335967 DOWN ENSG00000273599 RP11-59C5.3 - - - - - - - 10:124996064-125001491 114 90 99 46 61 40 1.48563444026975 1.06592800057411 1.16320196698421 0.537102244563431 0.65223760640627 0.488537656385544 1.23825480260936 0.559292502451748 1.14663332088066 7.98694634671837e-05 0.000647413239845045 UP ENSG00000012124 CD22 CD22 molecule [Source:HGNC Symbol;Acc:HGNC:1643] GO:0016020|GO:0005576|GO:0005488|GO:1903561|GO:0030246|GO:0007155|GO:0043227|GO:0031224|GO:0005515|GO:0031982|GO:0070062|GO:0016021 membrane|extracellular region|binding|extracellular vesicle|carbohydrate binding|cell adhesion|membrane-bounded organelle|intrinsic component of membrane|protein binding|vesicle|extracellular exosome|integral component of membrane K06467 CD22 antigen[-] hsa04514|hsa04640|hsa04662 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human) 19:35319261-35347355 93 110 149 216 276 299 0.4033674369029 0.433601277129048 0.58266577523283 0.839402497736954 0.982189856690062 1.21539677197877 0.473211496421593 1.01232970880193 -1.09712221366321 7.99221610148002e-05 0.000647664548028188 DOWN ENSG00000085365 SCAMP1 secretory carrier membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:10563] GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0030672|GO:0008021|GO:0043229|GO:0051641|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0006810|GO:0032940|GO:0031982|GO:0030141|GO:0043231|GO:0030133|GO:0005737|GO:0012506|GO:0045184|GO:0030658|GO:0008104|GO:0051649|GO:0030667|GO:0010008|GO:0016021|GO:0005794|GO:0005768|GO:0016192|GO:0005802|GO:0031410|GO:0015031|GO:0016023|GO:0006887|GO:0070382|GO:0046907|GO:0042588|GO:0055037|GO:0031981|GO:0031988|GO:0005654|GO:0030659|GO:0046903|GO:0005634|GO:0055038|GO:0042589|GO:0048193|GO:0030135|GO:0030136|GO:0006892 synapse|cell|membrane|cellular process|cell junction|binding|synaptic vesicle membrane|synaptic vesicle|intracellular organelle|cellular localization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|transport|secretion by cell|vesicle|secretory granule|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|vesicle membrane|establishment of protein localization|transport vesicle membrane|protein localization|establishment of localization in cell|secretory granule membrane|endosome membrane|integral component of membrane|Golgi apparatus|endosome|vesicle-mediated transport|trans-Golgi network|cytoplasmic vesicle|protein transport|cytoplasmic, membrane-bounded vesicle|exocytosis|exocytic vesicle|intracellular transport|zymogen granule|recycling endosome|nuclear lumen|membrane-bounded vesicle|nucleoplasm|cytoplasmic vesicle membrane|secretion|nucleus|recycling endosome membrane|zymogen granule membrane|Golgi vesicle transport|coated vesicle|clathrin-coated vesicle|post-Golgi vesicle-mediated transport - - - - 5:78360583-78479071 377 452 842 994 1205 1434 2.49791860800045 2.72179855648699 5.02994736472502 5.90094151275723 6.55076490611647 8.90461560532649 3.41655484307082 7.11877400806673 -1.05908651695419 8.01042114152721e-05 0.000648963670988204 DOWN ENSG00000187848 P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 [Source:HGNC Symbol;Acc:HGNC:15459] GO:0032502|GO:0032991|GO:0004871|GO:0005215|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0004872|GO:0022857|GO:0051606|GO:0050794|GO:0043229|GO:0051050|GO:0006950|GO:0043167|GO:0009628|GO:0051641|GO:0045177|GO:0038023|GO:0023051|GO:0016043|GO:0043227|GO:0044708|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0042802|GO:0060341|GO:0048266|GO:0019866|GO:0009888|GO:0048468|GO:0006810|GO:0016324|GO:0007275|GO:0010524|GO:0048513|GO:0050877|GO:0043168|GO:0001882|GO:0043270|GO:0022607|GO:0061061|GO:0005887|GO:0043231|GO:0010243|GO:0004888|GO:0003012|GO:0007267|GO:0043235|GO:0005635|GO:0042592|GO:0009966|GO:0019725|GO:0022891|GO:0032388|GO:0010646|GO:0031226|GO:0007154|GO:0055085|GO:0009593|GO:0033555|GO:0007165|GO:0050808|GO:0051649|GO:2000021|GO:0001666|GO:0008217|GO:0031965|GO:0000166|GO:0048869|GO:0016021|GO:0009967|GO:0031301|GO:0010033|GO:0003013|GO:1902533|GO:0009743|GO:0005639|GO:0006936|GO:0007166|GO:0014074|GO:0035639|GO:0007528|GO:0042692|GO:0048878|GO:0046683|GO:0032386|GO:0001883|GO:0001976|GO:0060537|GO:0015267|GO:0046907|GO:0006811|GO:0032549|GO:0055082|GO:0015075|GO:0007600|GO:0005637|GO:0033198|GO:0006461|GO:0055001|GO:0043269|GO:0014070|GO:0048265|GO:0035556|GO:0017076|GO:0010522|GO:0030154|GO:0007517|GO:1902531|GO:0051928|GO:0008015|GO:0005634|GO:0003073|GO:0034220|GO:0055002|GO:0050850|GO:0015276|GO:0060538|GO:0098655|GO:0005216|GO:0006939|GO:0050954|GO:0051259|GO:0005524|GO:0006812|GO:0030554|GO:0001614|GO:0060402|GO:0016482|GO:0051146|GO:0003029|GO:0050801|GO:0014706|GO:0019932|GO:0007606|GO:0050848|GO:0006873|GO:0008324|GO:0035590|GO:0050909|GO:0007605|GO:0007519|GO:0005230|GO:0048747|GO:0014902|GO:0030001|GO:0019722|GO:0014904|GO:0051924|GO:0005261|GO:0051260|GO:0030003|GO:0007268|GO:0014832|GO:0004931|GO:0030432|GO:0005231|GO:0048741|GO:0055065|GO:0007274|GO:0006875|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0060401|GO:0007204 developmental process|macromolecular complex|signal transducer activity|transporter activity|behavior|signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|transmembrane transporter activity|detection of stimulus|regulation of cellular process|intracellular organelle|positive regulation of transport|response to stress|ion binding|response to abiotic stimulus|cellular localization|apical part of cell|signaling receptor activity|regulation of signaling|cellular component organization|membrane-bounded organelle|single-organism behavior|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|identical protein binding|regulation of cellular localization|behavioral response to pain|organelle inner membrane|tissue development|cell development|transport|apical plasma membrane|multicellular organism development|positive regulation of calcium ion transport into cytosol|animal organ development|neurological system process|anion binding|nucleoside binding|positive regulation of ion transport|cellular component assembly|muscle structure development|integral component of plasma membrane|intracellular membrane-bounded organelle|response to organonitrogen compound|transmembrane signaling receptor activity|muscle system process|cell-cell signaling|receptor complex|nuclear envelope|homeostatic process|regulation of signal transduction|cellular homeostasis|substrate-specific transmembrane transporter activity|positive regulation of intracellular transport|regulation of cell communication|intrinsic component of plasma membrane|cell communication|transmembrane transport|detection of chemical stimulus|multicellular organismal response to stress|signal transduction|synapse organization|establishment of localization in cell|regulation of ion homeostasis|response to hypoxia|regulation of blood pressure|nuclear membrane|nucleotide binding|cellular developmental process|integral component of membrane|positive regulation of signal transduction|integral component of organelle membrane|response to organic substance|circulatory system process|positive regulation of intracellular signal transduction|response to carbohydrate|integral component of nuclear inner membrane|muscle contraction|cell surface receptor signaling pathway|response to purine-containing compound|purine ribonucleoside triphosphate binding|neuromuscular junction development|muscle cell differentiation|chemical homeostasis|response to organophosphorus|regulation of intracellular transport|purine nucleoside binding|neurological system process involved in regulation of systemic arterial blood pressure|muscle tissue development|channel activity|intracellular transport|ion transport|ribonucleoside binding|cellular chemical homeostasis|ion transmembrane transporter activity|sensory perception|nuclear inner membrane|response to ATP|protein complex assembly|muscle cell development|regulation of ion transport|response to organic cyclic compound|response to pain|intracellular signal transduction|purine nucleotide binding|regulation of calcium ion transport into cytosol|cell differentiation|muscle organ development|regulation of intracellular signal transduction|positive regulation of calcium ion transport|blood circulation|nucleus|regulation of systemic arterial blood pressure|ion transmembrane transport|striated muscle cell development|positive regulation of calcium-mediated signaling|ligand-gated ion channel activity|skeletal muscle organ development|cation transmembrane transport|ion channel activity|smooth muscle contraction|sensory perception of mechanical stimulus|protein oligomerization|ATP binding|cation transport|adenyl nucleotide binding|purinergic nucleotide receptor activity|calcium ion transport into cytosol|cytosolic transport|striated muscle cell differentiation|detection of hypoxic conditions in blood by carotid body chemoreceptor signaling|ion homeostasis|striated muscle tissue development|second-messenger-mediated signaling|sensory perception of chemical stimulus|regulation of calcium-mediated signaling|cellular ion homeostasis|cation transmembrane transporter activity|purinergic nucleotide receptor signaling pathway|sensory perception of taste|sensory perception of sound|skeletal muscle tissue development|extracellular ligand-gated ion channel activity|muscle fiber development|myotube differentiation|metal ion transport|calcium-mediated signaling|myotube cell development|regulation of calcium ion transport|cation channel activity|protein homooligomerization|cellular cation homeostasis|synaptic transmission|urinary bladder smooth muscle contraction|extracellular ATP-gated cation channel activity|peristalsis|excitatory extracellular ligand-gated ion channel activity|skeletal muscle fiber development|metal ion homeostasis|neuromuscular synaptic transmission|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K05216 P2X purinoceptor 2[-] hsa04080|hsa04020|hsa04742 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Taste transduction - Homo sapiens (human) 12:132618780-132622386 7 10 12 1 1 2 0.112181257614772 0.145644091706093 0.173388451282411 0.0143517882874518 0.0131543333902022 0.0300343205155043 0.143737933534425 0.0191801473977194 2.90575513774954 8.02410393241094e-05 0.000649895818768845 UP ENSG00000073921 PICALM phosphatidylinositol binding clathrin assembly protein [Source:HGNC Symbol;Acc:HGNC:15514] GO:0032502|GO:0032991|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0060090|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0051051|GO:0044237|GO:0051641|GO:0044297|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0009058|GO:0005905|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0097060|GO:0031090|GO:0019222|GO:0030119|GO:0006725|GO:0035459|GO:0043025|GO:0006810|GO:0031623|GO:1901360|GO:0010941|GO:0098797|GO:0097418|GO:0060627|GO:0034641|GO:0043168|GO:0045806|GO:0005543|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0030276|GO:0045211|GO:0022607|GO:0030117|GO:0010942|GO:0043231|GO:0016234|GO:0005737|GO:0042734|GO:0032880|GO:0012506|GO:0042592|GO:0030666|GO:0030674|GO:0036477|GO:0006139|GO:0043085|GO:0008104|GO:0030132|GO:0044092|GO:0061024|GO:0051649|GO:0008219|GO:0050790|GO:0043086|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0005794|GO:0006996|GO:0098657|GO:0016192|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0006900|GO:0016050|GO:0031410|GO:0051345|GO:0010629|GO:0030131|GO:0048878|GO:0035091|GO:0051252|GO:0048261|GO:1901216|GO:0070997|GO:0010628|GO:0016023|GO:0032269|GO:0030665|GO:0046907|GO:0016188|GO:0006811|GO:0032050|GO:0030100|GO:0051247|GO:0048471|GO:0051346|GO:0006508|GO:0031988|GO:0006461|GO:1901214|GO:0030118|GO:0032270|GO:0030669|GO:0043603|GO:0030659|GO:0042982|GO:0044267|GO:0030122|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0030120|GO:0016070|GO:0010557|GO:0005634|GO:0035615|GO:0043112|GO:0010466|GO:0045893|GO:0034622|GO:0030139|GO:0048259|GO:0032774|GO:0030162|GO:0006812|GO:0030125|GO:2001141|GO:1902992|GO:0042987|GO:0043623|GO:0045862|GO:0005545|GO:0052547|GO:0030135|GO:0016197|GO:1902004|GO:0050435|GO:0045861|GO:0050801|GO:1902003|GO:0030128|GO:0006897|GO:0010952|GO:1902991|GO:0006351|GO:0006355|GO:0030136|GO:0048268|GO:1902961|GO:1902959|GO:0010950|GO:1902963|GO:0034205|GO:1903506|GO:0010951|GO:0006898|GO:0030001|GO:0045334|GO:0052548|GO:0097459|GO:0072583|GO:0055065|GO:0006826|GO:0055072|GO:0097286 developmental process|macromolecular complex|synapse|cell|membrane|cellular process|metabolic process|binding|binding, bridging|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|negative regulation of transport|cellular metabolic process|cellular localization|cell body|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|biosynthetic process|coated pit|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|synaptic membrane|organelle membrane|regulation of metabolic process|AP-type membrane coat adaptor complex|cellular aromatic compound metabolic process|cargo loading into vesicle|neuronal cell body|transport|receptor internalization|organic cyclic compound metabolic process|regulation of cell death|plasma membrane protein complex|neurofibrillary tangle|regulation of vesicle-mediated transport|cellular nitrogen compound metabolic process|anion binding|negative regulation of endocytosis|phospholipid binding|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|clathrin binding|postsynaptic membrane|cellular component assembly|membrane coat|positive regulation of cell death|intracellular membrane-bounded organelle|inclusion body|cytoplasm|presynaptic membrane|regulation of protein localization|vesicle membrane|homeostatic process|endocytic vesicle membrane|protein binding, bridging|somatodendritic compartment|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|protein localization|clathrin coat of coated pit|negative regulation of molecular function|membrane organization|establishment of localization in cell|cell death|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|import into cell|vesicle-mediated transport|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|membrane budding|vesicle organization|cytoplasmic vesicle|positive regulation of hydrolase activity|negative regulation of gene expression|clathrin adaptor complex|chemical homeostasis|phosphatidylinositol binding|regulation of RNA metabolic process|negative regulation of receptor-mediated endocytosis|positive regulation of neuron death|neuron death|positive regulation of gene expression|cytoplasmic, membrane-bounded vesicle|negative regulation of cellular protein metabolic process|clathrin-coated vesicle membrane|intracellular transport|synaptic vesicle maturation|ion transport|clathrin heavy chain binding|regulation of endocytosis|positive regulation of protein metabolic process|perinuclear region of cytoplasm|negative regulation of hydrolase activity|proteolysis|membrane-bounded vesicle|protein complex assembly|regulation of neuron death|clathrin coat|positive regulation of cellular protein metabolic process|clathrin-coated endocytic vesicle membrane|cellular amide metabolic process|cytoplasmic vesicle membrane|amyloid precursor protein metabolic process|cellular protein metabolic process|AP-2 adaptor complex|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|vesicle coat|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|clathrin adaptor activity|receptor metabolic process|negative regulation of peptidase activity|positive regulation of transcription, DNA-templated|cellular macromolecular complex assembly|endocytic vesicle|regulation of receptor-mediated endocytosis|RNA biosynthetic process|regulation of proteolysis|cation transport|clathrin vesicle coat|regulation of RNA biosynthetic process|negative regulation of amyloid precursor protein catabolic process|amyloid precursor protein catabolic process|cellular protein complex assembly|positive regulation of proteolysis|1-phosphatidylinositol binding|regulation of peptidase activity|coated vesicle|endosomal transport|positive regulation of beta-amyloid formation|beta-amyloid metabolic process|negative regulation of proteolysis|ion homeostasis|regulation of beta-amyloid formation|clathrin coat of endocytic vesicle|endocytosis|positive regulation of peptidase activity|regulation of amyloid precursor protein catabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|clathrin-coated vesicle|clathrin coat assembly|positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|positive regulation of endopeptidase activity|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|beta-amyloid formation|regulation of nucleic acid-templated transcription|negative regulation of endopeptidase activity|receptor-mediated endocytosis|metal ion transport|clathrin-coated endocytic vesicle|regulation of endopeptidase activity|iron ion import into cell|clathrin-mediated endocytosis|metal ion homeostasis|iron ion transport|iron ion homeostasis|iron ion import - - - - 11:85957684-86069882 1002 1156 2437 2910 3504 3867 5.78457056406645 6.06514673157886 12.6844915074341 15.0519922973411 16.5972193011779 20.9221523719758 8.17806960102647 17.5237879901649 -1.09948241921282 8.02736975306855e-05 0.000649983988630617 DOWN ENSG00000186814 ZSCAN30 zinc finger and SCAN domain containing 30 [Source:HGNC Symbol;Acc:HGNC:33517] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 18:35251058-35290245 119 181 150 340 278 461 0.451324777548152 0.623882478203284 0.512918385399822 1.15536885882748 0.865079765512733 1.6386004248378 0.529375213717086 1.21968301639267 -1.2041437022686 8.05505133755126e-05 0.000652017135651779 DOWN ENSG00000224346 BICD1P1 bicaudal D homolog 1 (Drosophila) pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:51374] - - - - - - 2:200844240-200845461 6 11 2 0 0 0 0.347300636406703 0.578715832674005 0.104383063824408 0 0 0 0.343466510968372 0 Inf 8.07504556291894e-05 0.000653267798191115 UP ENSG00000086619 ERO1B endoplasmic reticulum oxidoreductase beta [Source:HGNC Symbol;Acc:HGNC:14355] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0042445|GO:0016043|GO:0006457|GO:0043227|GO:0016853|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0006575|GO:1901360|GO:0006082|GO:0034641|GO:0043062|GO:0044281|GO:0046483|GO:0043231|GO:0022417|GO:0005737|GO:0006520|GO:0016486|GO:0042592|GO:0019725|GO:0016667|GO:0016860|GO:0005783|GO:0051082|GO:0010817|GO:0045454|GO:0019538|GO:0055114|GO:0006518|GO:0048878|GO:0051604|GO:0015036|GO:0019471|GO:0006508|GO:0016671|GO:0043603|GO:0010467|GO:0030198|GO:1901142|GO:0030070|GO:0016485|GO:0015035|GO:0019752|GO:0003756|GO:0033500|GO:0042593|GO:0032787 cell|membrane|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|hormone metabolic process|cellular component organization|protein folding|membrane-bounded organelle|isomerase activity|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|cellular modified amino acid metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|extracellular structure organization|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|protein maturation by protein folding|cytoplasm|cellular amino acid metabolic process|peptide hormone processing|homeostatic process|cellular homeostasis|oxidoreductase activity, acting on a sulfur group of donors|intramolecular oxidoreductase activity|endoplasmic reticulum|unfolded protein binding|regulation of hormone levels|cell redox homeostasis|protein metabolic process|oxidation-reduction process|peptide metabolic process|chemical homeostasis|protein maturation|disulfide oxidoreductase activity|4-hydroxyproline metabolic process|proteolysis|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|cellular amide metabolic process|gene expression|extracellular matrix organization|insulin metabolic process|insulin processing|protein processing|protein disulfide oxidoreductase activity|carboxylic acid metabolic process|protein disulfide isomerase activity|carbohydrate homeostasis|glucose homeostasis|monocarboxylic acid metabolic process K10976 ERO1-like protein beta [EC:1.8.4.-][-] hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) 1:236215555-236281985 35 47 110 159 151 406 0.427668698325984 0.521943966552796 1.21184755131755 1.74075020112635 1.51386586242124 4.64940359774967 0.72048673873211 2.63467322043242 -1.87058025338445 8.19483109886395e-05 0.000662106867727968 DOWN ENSG00000255725 TDGP1 thymine-DNA glycosylase pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:49891] - - - - - - 12:25803298-25804526 41 68 34 13 16 22 2.35983867636047 3.55698660811776 1.76435070751385 0.670397904623945 0.755577536132715 1.18673551550936 2.56039199733069 0.870903652088673 1.55577967681059 8.2410940695324e-05 0.000665304549355923 UP ENSG00000182196 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 [Source:HGNC Symbol;Acc:HGNC:18076] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0005730|GO:0003723|GO:0031981|GO:0005654|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0016604|GO:0016071|GO:0044822|GO:0016607|GO:0006397|GO:0008380 cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|nucleolus|RNA binding|nuclear lumen|nucleoplasm|gene expression|RNA metabolic process|nucleus|RNA processing|nuclear body|mRNA metabolic process|poly(A) RNA binding|nuclear speck|mRNA processing|RNA splicing - - - - 12:122980060-122982913 233 233 205 513 525 405 1.33660547950975 1.21474104363645 1.06026547266083 2.63670872748321 2.47101281785144 2.17736693552795 1.20387066526901 2.4283628269542 -1.01230358567953 8.32875094203359e-05 0.000671654593796518 DOWN ENSG00000079393 DUSP13 dual specificity phosphatase 13 [Source:HGNC Symbol;Acc:HGNC:19681] GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0044702|GO:0051321|GO:0071704|GO:0019953|GO:0044237|GO:0016043|GO:0032504|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0048609|GO:0007049|GO:0022402|GO:0016788|GO:0005737|GO:0007276|GO:0007126|GO:0016021|GO:0019538|GO:0006996|GO:0048232|GO:0043412|GO:0036211|GO:0006796|GO:0044267|GO:0042578|GO:0007283|GO:0016311|GO:0016791|GO:0006464|GO:0006470|GO:0004721|GO:0035335|GO:0008138|GO:0004725 reproduction|cell|membrane|cellular process|reproductive process|metabolic process|binding|catalytic activity|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|sexual reproduction|cellular metabolic process|cellular component organization|multicellular organism reproduction|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|multicellular organismal reproductive process|cell cycle|cell cycle process|hydrolase activity, acting on ester bonds|cytoplasm|gamete generation|meiotic nuclear division|integral component of membrane|protein metabolic process|organelle organization|male gamete generation|macromolecule modification|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|phosphoric ester hydrolase activity|spermatogenesis|dephosphorylation|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|peptidyl-tyrosine dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity - - - - 10:75094432-75109221 53 72 125 186 189 281 0.489623153797178 0.604503819993862 1.04114181537823 1.53956560997767 1.43257701243033 2.43288775028106 0.711756263056423 1.80167679089635 -1.33988503620741 8.34604519380076e-05 0.00067268583481568 DOWN ENSG00000185760 KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 [Source:HGNC Symbol;Acc:HGNC:6299] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0004872|GO:0022857|GO:0050794|GO:0016043|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0006810|GO:0098797|GO:0022607|GO:0030117|GO:0005887|GO:0005737|GO:0007267|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0071804|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0008076|GO:0034765|GO:0034702|GO:0006461|GO:0043269|GO:0030118|GO:0071805|GO:0034220|GO:0015276|GO:0098655|GO:0005216|GO:0034703|GO:0006812|GO:0008324|GO:0005244|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0005242|GO:0007268|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249|GO:0005251 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|binding|receptor activity|transmembrane transporter activity|regulation of cellular process|cellular component organization|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|transport|plasma membrane protein complex|cellular component assembly|membrane coat|integral component of plasma membrane|cytoplasm|cell-cell signaling|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|cellular potassium ion transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|voltage-gated potassium channel complex|regulation of ion transmembrane transport|ion channel complex|protein complex assembly|regulation of ion transport|clathrin coat|potassium ion transmembrane transport|ion transmembrane transport|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|cation channel complex|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|inward rectifier potassium channel activity|synaptic transmission|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity|delayed rectifier potassium channel activity K04930 potassium voltage-gated channel KQT-like subfamily member 5[-] hsa04725 Cholinergic synapse - Homo sapiens (human) 6:72621792-73198851 0 0 0 5 8 4 0 0 0 0.0142889702348553 0.0209384675607873 0.0119563032788092 0 0.0157279136914839 -Inf 8.36133730609716e-05 0.000673736474861605 DOWN ENSG00000151576 QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25771] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0019867|GO:0009058|GO:0005622|GO:0016740|GO:0031090|GO:0006725|GO:1901360|GO:0034641|GO:0044281|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0031966|GO:0006139|GO:0055086|GO:0016757|GO:0044249|GO:0005740|GO:0046872|GO:0043412|GO:0005741|GO:0009116|GO:0005739|GO:1901137|GO:0010467|GO:0016763|GO:0016070|GO:0008479|GO:0006396|GO:0034660|GO:0009451|GO:0046914|GO:0006400|GO:0006399|GO:0008270|GO:0008033|GO:0008616 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|outer membrane|biosynthetic process|intracellular|transferase activity|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|mitochondrial membrane|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|transferase activity, transferring glycosyl groups|cellular biosynthetic process|mitochondrial envelope|metal ion binding|macromolecule modification|mitochondrial outer membrane|nucleoside metabolic process|mitochondrion|carbohydrate derivative biosynthetic process|gene expression|transferase activity, transferring pentosyl groups|RNA metabolic process|queuine tRNA-ribosyltransferase activity|RNA processing|ncRNA metabolic process|RNA modification|transition metal ion binding|tRNA modification|tRNA metabolic process|zinc ion binding|tRNA processing|queuosine biosynthetic process - - - - 3:114005833-114088422 1552 1557 858 751 801 494 7.05822243722626 6.4353530577601 3.51807682253772 3.06013792550635 2.98885131989741 2.10551936402958 5.67055077250803 2.71816953647778 1.06085342683081 8.36632774074477e-05 0.000673956687458701 UP ENSG00000189157 FAM47E family with sequence similarity 47 member E [Source:HGNC Symbol;Acc:HGNC:34343] - - - - - - 4:76214040-76283780 9 9 18 38 60 30 0.0487096554711503 0.0442705541981251 0.0878351136909597 0.184269952627978 0.26643324406954 0.152169428334595 0.0602717744534117 0.200957541677371 -1.73733627617107 8.41432587558122e-05 0.000677457617825247 DOWN ENSG00000152454 ZNF256 zinc finger protein 256 [Source:HGNC Symbol;Acc:HGNC:13049] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0010629|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0006351|GO:0006355|GO:1903507|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 19:57940833-57947675 145 157 236 85 71 109 2.4835020785958 2.4438588017123 3.64436314312396 1.30440972785735 0.997745132366124 1.74965204937688 2.85724134114402 1.35060230320012 1.08101997793069 8.46246011526484e-05 0.000680782226572666 UP ENSG00000233673 ANAPC1P1 anaphase promoting complex subunit 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44150] - - - - - - 2:86861825-86922693 14 21 20 65 50 47 0.331659793108911 0.452131201714109 0.427180522416032 1.3796366791407 0.971829440569689 1.04348731857172 0.403657172413017 1.13165114609404 -1.48722685567527 8.54276395056821e-05 0.000686687331664683 DOWN ENSG00000128923 FAM63B family with sequence similarity 63 member B [Source:HGNC Symbol;Acc:HGNC:26954] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0031981|GO:0005654|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nuclear lumen|nucleoplasm|nucleus - - - - 15:58771192-58861900 196 201 332 479 458 717 0.744079909157373 0.693488871494168 1.13635910889706 1.62928323761 1.4265823178175 2.5510048494396 0.857975963182867 1.86895680162237 -1.12322408828917 8.56824055443769e-05 0.000688364514295433 DOWN ENSG00000144834 TAGLN3 transgelin 3 [Source:HGNC Symbol;Acc:HGNC:29868] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0043209|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0043231|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:0007417|GO:0010629|GO:0051252|GO:0010467|GO:0007399|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 developmental process|cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|myelin sheath|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|central nervous system development|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|nervous system development|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 3:111998664-112013887 10 19 4 1 1 1 0.110624902953026 0.19103677888023 0.0398986875174936 0.00990753730072131 0.00908089264691155 0.0103668666527554 0.11385345645025 0.00978509886679609 3.54044785270811 8.60050535532614e-05 0.000690770747586512 UP ENSG00000176383 B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:15683] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0044262|GO:0006082|GO:0044281|GO:0043231|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0005976|GO:0034645|GO:0043412|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0033692|GO:0070085|GO:1901137|GO:0044267|GO:0042339|GO:0000139|GO:0009059|GO:0016051|GO:0009101|GO:0043413|GO:0008378|GO:0000271|GO:0008375|GO:0030309|GO:0030311|GO:0006024|GO:0030203|GO:0018146|GO:0006464|GO:0016266|GO:0008532|GO:0043687 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|cellular carbohydrate metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|polysaccharide metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|cellular polysaccharide biosynthetic process|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|keratan sulfate metabolic process|Golgi membrane|macromolecule biosynthetic process|carbohydrate biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|galactosyltransferase activity|polysaccharide biosynthetic process|acetylglucosaminyltransferase activity|poly-N-acetyllactosamine metabolic process|poly-N-acetyllactosamine biosynthetic process|glycosaminoglycan biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate biosynthetic process|cellular protein modification process|O-glycan processing|N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity|post-translational protein modification K07971 beta-1,3-N-acetylglucosaminyltransferase 4 [EC:2.4.1.-][-] hsa01100|hsa00601 Metabolic pathways - Homo sapiens (human)|Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human) 12:122203543-122208952 47 51 63 22 16 29 0.376602074188491 0.371395880232262 0.45513334314254 0.157942301669497 0.105188580868499 0.217772787291009 0.401043765854431 0.160301223276335 1.32297425149566 8.7033880980075e-05 0.000698282580698511 UP ENSG00000143412 ANXA9 annexin A9 [Source:HGNC Symbol;Acc:HGNC:547] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:0036094|GO:1903561|GO:0004872|GO:0043167|GO:0009986|GO:0038023|GO:0072341|GO:0007155|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0042802|GO:0016337|GO:0030594|GO:0043168|GO:0005543|GO:0031982|GO:0098609|GO:0043169|GO:0004888|GO:0005737|GO:0007267|GO:0043177|GO:0046983|GO:0001786|GO:0007154|GO:0070062|GO:0005829|GO:0046872|GO:0015464|GO:0005544|GO:0031406|GO:0042803|GO:0005509|GO:0016597|GO:0007268 signal transducer activity|signaling|cell|cellular process|extracellular region|binding|small molecule binding|extracellular vesicle|receptor activity|ion binding|cell surface|signaling receptor activity|modified amino acid binding|cell adhesion|membrane-bounded organelle|lipid binding|intracellular|protein binding|identical protein binding|single organismal cell-cell adhesion|neurotransmitter receptor activity|anion binding|phospholipid binding|vesicle|cell-cell adhesion|cation binding|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|organic acid binding|protein dimerization activity|phosphatidylserine binding|cell communication|extracellular exosome|cytosol|metal ion binding|acetylcholine receptor activity|calcium-dependent phospholipid binding|carboxylic acid binding|protein homodimerization activity|calcium ion binding|amino acid binding|synaptic transmission - - - - 1:150982017-150995634 185 213 352 524 487 601 6.38981378145755 6.68614539428695 10.9615593592087 16.2160531036995 13.8010675538592 19.4544627252378 8.01250617831773 16.4905277942655 -1.04131210499076 8.70905982059911e-05 0.000698549897593138 DOWN ENSG00000234840 LINC01239 long intergenic non-protein coding RNA 1239 [Source:HGNC Symbol;Acc:HGNC:49796] - - - - - - 9:22646200-22824213 2 0 2 15 6 14 0.0529442836438361 0 0.0477380628717916 0.355793686375935 0.130316243061121 0.347358334127566 0.0335607821718759 0.277822754521541 -3.04931652031654 8.82044025213555e-05 0.000706913888019476 DOWN ENSG00000174808 BTC betacellulin [Source:HGNC Symbol;Acc:HGNC:1121] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0031224|GO:0005615|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0003014|GO:0006935|GO:0045087|GO:0045595|GO:0048468|GO:0022402|GO:0051130|GO:0010941|GO:0007275|GO:0051302|GO:0005102|GO:0006952|GO:0031325|GO:0051128|GO:0045597|GO:0010243|GO:0048144|GO:0006928|GO:0009966|GO:0045787|GO:0060548|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0009725|GO:0008219|GO:0050790|GO:0030030|GO:0051781|GO:0051301|GO:0048869|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0050878|GO:0006996|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0090068|GO:0007166|GO:0070851|GO:1903047|GO:0043412|GO:0043069|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0000278|GO:0048145|GO:0007346|GO:0043434|GO:0044344|GO:0010564|GO:0051247|GO:0048146|GO:0070848|GO:0002764|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0007067|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0045931|GO:0008083|GO:0032870|GO:0043067|GO:0010638|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:0035810|GO:1901653|GO:0043408|GO:0005154|GO:0007088|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0048017|GO:0007167|GO:0071375|GO:0043410|GO:0042981|GO:0045840|GO:0043066|GO:0032868|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0006915|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:0048015|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0042327|GO:0007169|GO:0048010|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|intrinsic component of membrane|extracellular space|regulation of developmental process|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|renal system process|chemotaxis|innate immune response|regulation of cell differentiation|cell development|cell cycle process|positive regulation of cellular component organization|regulation of cell death|multicellular organism development|regulation of cell division|receptor binding|defense response|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell differentiation|response to organonitrogen compound|fibroblast proliferation|movement of cell or subcellular component|regulation of signal transduction|positive regulation of cell cycle|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|response to hormone|cell death|regulation of catalytic activity|cell projection organization|positive regulation of cell division|cell division|cellular developmental process|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|organelle organization|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|positive regulation of cell cycle process|cell surface receptor signaling pathway|growth factor receptor binding|mitotic cell cycle process|macromolecule modification|negative regulation of programmed cell death|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|mitotic cell cycle|regulation of fibroblast proliferation|regulation of mitotic cell cycle|response to peptide hormone|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|response to growth factor|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|positive regulation of mitotic cell cycle|growth factor activity|cellular response to hormone stimulus|regulation of programmed cell death|positive regulation of organelle organization|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|positive regulation of urine volume|cellular response to peptide|regulation of MAPK cascade|epidermal growth factor receptor binding|regulation of mitotic nuclear division|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of apoptotic process|positive regulation of mitotic nuclear division|negative regulation of apoptotic process|response to insulin|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K09783 betacellulin[-] hsa04012 ErbB signaling pathway - Homo sapiens (human) 4:74744759-74794686 43 60 85 170 147 138 0.977098894681446 1.23907424501901 1.74139657848902 3.46108584448751 2.74064658204851 2.93882464829153 1.31918990606316 3.04685235827585 -1.20766732787608 8.86629790792733e-05 0.000710398437314177 DOWN ENSG00000142621 FHAD1 forkhead-associated (FHA) phosphopeptide binding domain 1 [Source:HGNC Symbol;Acc:HGNC:29408] GO:0005488|GO:0005515 binding|protein binding - - - - 1:15247272-15400283 12 16 29 43 58 88 0.0437178254275572 0.0529740347770053 0.0952531355888048 0.140355383672855 0.173364276982495 0.300450675219818 0.0639816652644558 0.204723445291723 -1.67794588442862 8.95710349119242e-05 0.000716520277668967 DOWN ENSG00000182287 AP1S2 adaptor related protein complex 1 sigma 2 subunit [Source:HGNC Symbol;Acc:HGNC:560] GO:0032991|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0019882|GO:0043229|GO:0006950|GO:0051641|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005905|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0016032|GO:0030119|GO:0008565|GO:0019884|GO:0006810|GO:0050688|GO:0006952|GO:0031982|GO:0030117|GO:0098542|GO:0043231|GO:0005774|GO:0005737|GO:0012506|GO:0009615|GO:0030666|GO:0045184|GO:0008104|GO:0061024|GO:0051649|GO:0002504|GO:0051607|GO:0048002|GO:0005794|GO:0016192|GO:0005829|GO:0005802|GO:0031410|GO:0015031|GO:0005773|GO:0016023|GO:0030665|GO:0046907|GO:0031988|GO:0034613|GO:0030669|GO:0030659|GO:0000139|GO:0050690|GO:0002495|GO:0030139|GO:0000323|GO:0048193|GO:0006886|GO:0030135|GO:0019886|GO:0032588|GO:0005765|GO:0030136|GO:0005764|GO:0006892|GO:0045334 macromolecular complex|transporter activity|immune system process|cell|membrane|cellular process|response to stimulus|binding|antigen processing and presentation|intracellular organelle|response to stress|cellular localization|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|coated pit|intracellular|regulation of immune system process|protein binding|protein complex|endomembrane system|organelle membrane|viral process|AP-type membrane coat adaptor complex|protein transporter activity|antigen processing and presentation of exogenous antigen|transport|regulation of defense response to virus|defense response|vesicle|membrane coat|defense response to other organism|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|vesicle membrane|response to virus|endocytic vesicle membrane|establishment of protein localization|protein localization|membrane organization|establishment of localization in cell|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|defense response to virus|antigen processing and presentation of peptide antigen|Golgi apparatus|vesicle-mediated transport|cytosol|trans-Golgi network|cytoplasmic vesicle|protein transport|vacuole|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|intracellular transport|membrane-bounded vesicle|cellular protein localization|clathrin-coated endocytic vesicle membrane|cytoplasmic vesicle membrane|Golgi membrane|regulation of defense response to virus by virus|antigen processing and presentation of peptide antigen via MHC class II|endocytic vesicle|lytic vacuole|Golgi vesicle transport|intracellular protein transport|coated vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class II|trans-Golgi network membrane|lysosomal membrane|clathrin-coated vesicle|lysosome|post-Golgi vesicle-mediated transport|clathrin-coated endocytic vesicle K12394 AP-1 complex subunit sigma 1/2[-] hsa04142 Lysosome - Homo sapiens (human) X:15825806-15855014 66 103 137 205 319 218 0.643236971262825 0.912320548195374 1.2038246768134 1.79011546101169 2.55086096076821 1.99119949405525 0.919794065423866 2.11072530527838 -1.19835604070848 8.98082473274286e-05 0.000718033051878161 DOWN ENSG00000153814 JAZF1 JAZF zinc finger 1 [Source:HGNC Symbol;Acc:HGNC:28917] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0043234|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0017053|GO:0009890|GO:0006139|GO:0006629|GO:0044249|GO:0031324|GO:0031323|GO:0005730|GO:0010468|GO:0034645|GO:0003714|GO:0046872|GO:0010629|GO:0051252|GO:0031981|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 macromolecular complex|cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein complex|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|transcriptional repressor complex|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|lipid metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|nucleolus|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|nuclear lumen|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 7:27830573-28180743 16 20 9 32 63 92 0.227589637667311 0.258545353223686 0.115417070941796 0.40782689829211 0.735253179447618 1.22643560406284 0.200517353944264 0.789838560600856 -1.97783070178783 8.9938111901146e-05 0.000718878819999147 DOWN ENSG00000240409 MTATP8P1 mitochondrially encoded ATP synthase 8 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44571] - - - - - - 1:633535-633741 35 9 592 5 19 14 11.9602613266141 2.79524706941785 182.394229742746 1.5307835938558 5.32722875995763 4.48377521154037 65.7165793795927 3.78059585511793 4.11957184948335 9.15379330665527e-05 0.000731079040601623 UP ENSG00000131153 GINS2 GINS complex subunit 2 (Psf2 homolog) [Source:HGNC Symbol;Acc:HGNC:24575] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0006281|GO:0006725|GO:0022402|GO:1901360|GO:0031261|GO:0034641|GO:0046483|GO:0033554|GO:0016817|GO:0043231|GO:0006139|GO:0031298|GO:0044249|GO:0006996|GO:0051276|GO:0034645|GO:0000725|GO:1903047|GO:0000811|GO:0006302|GO:0016818|GO:0033260|GO:0000278|GO:0005657|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0009059|GO:0005634|GO:0006974|GO:0006270|GO:0000724|GO:0006260|GO:0043596|GO:0022616|GO:0006310|GO:0071103|GO:0016462|GO:1902975|GO:0006271|GO:0006261|GO:0032392|GO:0017111|GO:0000727|GO:0032508|GO:0004386|GO:0003678|GO:0043138 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|cell cycle|DNA repair|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|DNA replication preinitiation complex|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|replication fork protection complex|cellular biosynthetic process|organelle organization|chromosome organization|cellular macromolecule biosynthetic process|recombinational repair|mitotic cell cycle process|GINS complex|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nuclear DNA replication|mitotic cell cycle|replication fork|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|DNA replication initiation|double-strand break repair via homologous recombination|DNA replication|nuclear replication fork|DNA strand elongation|DNA recombination|DNA conformation change|pyrophosphatase activity|mitotic DNA replication initiation|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication|DNA geometric change|nucleoside-triphosphatase activity|double-strand break repair via break-induced replication|DNA duplex unwinding|helicase activity|DNA helicase activity|3'-5' DNA helicase activity - - - - 16:85676198-85690073 186 215 193 573 612 284 3.86403496531535 4.05926589476 3.61493793473536 10.665485532623 10.4315275317196 5.52938304164041 3.84607959827024 8.875465368661 -1.20643414561126 9.33481671988538e-05 0.000744938835486389 DOWN ENSG00000280287 RP13-554M15.7 - - - - - - - 12:132550729-132554947 99 86 79 39 45 44 1.65985326052107 1.31043090277316 1.19420857672666 0.585863255356361 0.619042648889815 0.691378378850819 1.38816424667363 0.632094761032332 1.13496551413398 9.35122009877441e-05 0.000746048436207406 UP ENSG00000277877 RP11-11N7.5 - GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - 1:244845167-244855497 37 32 36 86 88 91 3.37708544581349 2.65444344068416 2.96250725616509 7.03298189619568 6.59013602085619 7.78423034016357 2.99801204755425 7.13578275240515 -1.2510655125533 9.37900473877899e-05 0.000747665707534067 DOWN ENSG00000226419 SLC16A1-AS1 SLC16A1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49445] - - - - - - 1:112956415-113047055 24 45 25 98 102 71 0.132496040872931 0.22578311232467 0.124437518593691 0.484752298511954 0.462022311265971 0.367349727294248 0.160905557263764 0.438041445690724 -1.44485322429608 9.3836111310535e-05 0.000747833226659026 DOWN ENSG00000271009 RP11-346C20.3 - - - - - - - 16:73060470-73062316 0 1 0 4 8 10 0 0.0348228081954193 0 0.137262268774953 0.251397648417986 0.358921478358193 0.0116076027318064 0.249193798517044 -4.42412621114616 9.43561932325845e-05 0.000751376311753955 DOWN ENSG00000180953 ST20 suppressor of tumorigenicity 20 [Source:HGNC Symbol;Acc:HGNC:33520] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0022857|GO:0050794|GO:0043229|GO:0006950|GO:0016043|GO:0043227|GO:0019867|GO:0005622|GO:0005515|GO:0031090|GO:0042802|GO:0006810|GO:0010941|GO:0033554|GO:0010942|GO:0043231|GO:0005737|GO:0046983|GO:0031966|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0008219|GO:0006996|GO:0061025|GO:0005740|GO:0008053|GO:0007166|GO:0007005|GO:0005741|GO:0046982|GO:0015267|GO:0005739|GO:0012501|GO:0035556|GO:0043068|GO:0042803|GO:0043067|GO:0006974|GO:0097190|GO:0048284|GO:0097193|GO:0043065|GO:0097192|GO:0008637|GO:0008630|GO:0001836|GO:0042981|GO:0097191|GO:0006915 transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|transmembrane transporter activity|regulation of cellular process|intracellular organelle|response to stress|cellular component organization|membrane-bounded organelle|outer membrane|intracellular|protein binding|organelle membrane|identical protein binding|transport|regulation of cell death|cellular response to stress|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|mitochondrial membrane|cell communication|transmembrane transport|membrane organization|signal transduction|cell death|organelle organization|membrane fusion|mitochondrial envelope|mitochondrial fusion|cell surface receptor signaling pathway|mitochondrion organization|mitochondrial outer membrane|protein heterodimerization activity|channel activity|mitochondrion|programmed cell death|intracellular signal transduction|positive regulation of programmed cell death|protein homodimerization activity|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|organelle fusion|intrinsic apoptotic signaling pathway|positive regulation of apoptotic process|extrinsic apoptotic signaling pathway in absence of ligand|apoptotic mitochondrial changes|intrinsic apoptotic signaling pathway in response to DNA damage|release of cytochrome c from mitochondria|regulation of apoptotic process|extrinsic apoptotic signaling pathway|apoptotic process - - - - 15:79898840-79923702 83 64 69 200 163 166 2.70436844724447 1.89515768450504 2.0269854745475 5.83865577792843 4.35754841171079 5.06902075896326 2.208837202099 5.08840831620083 -1.20392735176838 9.49294746035634e-05 0.000755739875950609 DOWN ENSG00000214756 METTL12 methyltransferase like 12 [Source:HGNC Symbol;Acc:HGNC:33113] GO:0005623|GO:0008152|GO:0003824|GO:0032259|GO:0043229|GO:0043227|GO:0005622|GO:0016740|GO:0043231|GO:0005737|GO:0008168|GO:0005739 cell|metabolic process|catalytic activity|methylation|intracellular organelle|membrane-bounded organelle|intracellular|transferase activity|intracellular membrane-bounded organelle|cytoplasm|methyltransferase activity|mitochondrion - - - - 11:62665309-62668496 114 157 191 91 77 41 1.27454144804555 1.59524843544678 1.92528964181768 0.911558902083104 0.706330096330068 0.429598252606046 1.59835984177 0.682495750339739 1.22770027347176 9.70979045611135e-05 0.000771973593280288 UP ENSG00000165168 CYBB cytochrome b-245, beta polypeptide [Source:HGNC Symbol;Acc:HGNC:2578] GO:0009055|GO:0032991|GO:0005215|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0022857|GO:0016491|GO:0050794|GO:0019882|GO:0043229|GO:0006950|GO:0043167|GO:0006955|GO:0044237|GO:0016043|GO:0043227|GO:0048037|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0031090|GO:1903409|GO:0045087|GO:0019884|GO:0006810|GO:0098797|GO:0043168|GO:0006952|GO:0031982|GO:0005887|GO:0043231|GO:0043169|GO:0045730|GO:0005737|GO:0012506|GO:0072593|GO:0030666|GO:0046983|GO:0022891|GO:0043020|GO:0031226|GO:0016651|GO:0007154|GO:0055085|GO:0007165|GO:0050662|GO:0048002|GO:0000166|GO:0016021|GO:0044249|GO:0006996|GO:0055114|GO:0046872|GO:0042743|GO:0007166|GO:0020037|GO:0031410|GO:0050660|GO:0046982|GO:0016023|GO:0015267|GO:0006811|GO:0006954|GO:0015075|GO:0090382|GO:0050665|GO:0031988|GO:0034765|GO:0005739|GO:0002474|GO:0043269|GO:0050664|GO:0035556|GO:0030659|GO:0030670|GO:0006801|GO:0034220|GO:0042554|GO:0005216|GO:0042590|GO:0030139|GO:0016175|GO:0007167|GO:0007264|GO:0005244|GO:0045335|GO:0002479|GO:0007169|GO:0048010 electron carrier activity|macromolecular complex|transporter activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|transmembrane transporter activity|oxidoreductase activity|regulation of cellular process|antigen processing and presentation|intracellular organelle|response to stress|ion binding|immune response|cellular metabolic process|cellular component organization|membrane-bounded organelle|cofactor binding|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|organelle membrane|reactive oxygen species biosynthetic process|innate immune response|antigen processing and presentation of exogenous antigen|transport|plasma membrane protein complex|anion binding|defense response|vesicle|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|respiratory burst|cytoplasm|vesicle membrane|reactive oxygen species metabolic process|endocytic vesicle membrane|protein dimerization activity|substrate-specific transmembrane transporter activity|NADPH oxidase complex|intrinsic component of plasma membrane|oxidoreductase activity, acting on NAD(P)H|cell communication|transmembrane transport|signal transduction|coenzyme binding|antigen processing and presentation of peptide antigen|nucleotide binding|integral component of membrane|cellular biosynthetic process|organelle organization|oxidation-reduction process|metal ion binding|hydrogen peroxide metabolic process|cell surface receptor signaling pathway|heme binding|cytoplasmic vesicle|flavin adenine dinucleotide binding|protein heterodimerization activity|cytoplasmic, membrane-bounded vesicle|channel activity|ion transport|inflammatory response|ion transmembrane transporter activity|phagosome maturation|hydrogen peroxide biosynthetic process|membrane-bounded vesicle|regulation of ion transmembrane transport|mitochondrion|antigen processing and presentation of peptide antigen via MHC class I|regulation of ion transport|oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor|intracellular signal transduction|cytoplasmic vesicle membrane|phagocytic vesicle membrane|superoxide metabolic process|ion transmembrane transport|superoxide anion generation|ion channel activity|antigen processing and presentation of exogenous peptide antigen via MHC class I|endocytic vesicle|superoxide-generating NADPH oxidase activity|enzyme linked receptor protein signaling pathway|small GTPase mediated signal transduction|voltage-gated ion channel activity|phagocytic vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway K08008 NADPH oxidase[-] hsa04145|hsa04380|hsa04670|hsa04066|hsa04933 Phagosome - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) X:37780011-37813461 3 2 4 17 14 17 0.0458784736962698 0.027793904919615 0.0551474725436347 0.232910167576776 0.175645581082433 0.243622720476008 0.0429399503865065 0.217392823045072 -2.33991188296288 9.76822699940055e-05 0.00077591444440793 DOWN ENSG00000224356 RP11-151A6.4 - - - - - - - 13:100535741-100587146 0 1 0 9 6 6 0 0.0164411366914467 0 0.145806649886373 0.0890094584507451 0.101683279401 0.0054803788971489 0.112166462579373 -4.35522192861076 9.76975412517388e-05 0.00077591444440793 DOWN ENSG00000147697 GSDMC gasdermin C [Source:HGNC Symbol;Acc:HGNC:7151] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0005815|GO:0005739|GO:0005856|GO:0015630 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|microtubule organizing center|mitochondrion|cytoskeleton|microtubule cytoskeleton - - - - 8:129748196-129786888 8 13 20 41 33 86 0.144686398257561 0.213696075603624 0.326147031432951 0.664412881504003 0.489714347071993 1.45775486320321 0.228176501764712 0.870627363926402 -1.93190513829676 9.7917044355384e-05 0.000777450915474903 DOWN ENSG00000168077 SCARA3 scavenger receptor class A member 3 [Source:HGNC Symbol;Acc:HGNC:19000] GO:0032991|GO:0005623|GO:0016020|GO:0050896|GO:0005488|GO:0004872|GO:0043229|GO:0006950|GO:0042175|GO:0009628|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0009314|GO:0006810|GO:0043231|GO:0005737|GO:0006979|GO:0005783|GO:0016021|GO:0005581|GO:0038024|GO:0005794|GO:0016192|GO:0000139|GO:0009416|GO:0005044|GO:0009411|GO:0006897|GO:0006898|GO:0009650 macromolecular complex|cell|membrane|response to stimulus|binding|receptor activity|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|response to abiotic stimulus|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|organelle membrane|response to radiation|transport|intracellular membrane-bounded organelle|cytoplasm|response to oxidative stress|endoplasmic reticulum|integral component of membrane|collagen trimer|cargo receptor activity|Golgi apparatus|vesicle-mediated transport|Golgi membrane|response to light stimulus|scavenger receptor activity|response to UV|endocytosis|receptor-mediated endocytosis|UV protection - - - - 8:27633868-27676776 23 29 28 60 90 66 0.400929359100824 0.459428828228409 0.44004896686896 0.93709288319024 1.28719165844833 1.07822161876112 0.433469051399398 1.1008353867999 -1.34459785447767 9.82625707460846e-05 0.000779572359036304 DOWN ENSG00000064652 SNX24 sorting nexin 24 [Source:HGNC Symbol;Acc:HGNC:21533] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0008289|GO:0005622|GO:0031090|GO:0006810|GO:0043168|GO:0005543|GO:0031982|GO:0043231|GO:0005737|GO:0012506|GO:0045184|GO:0008104|GO:0031410|GO:0035091|GO:0015031|GO:0016023|GO:0031988|GO:0030659|GO:1901981|GO:0070273|GO:0032266|GO:0010314 cell|membrane|binding|intracellular organelle|ion binding|membrane-bounded organelle|lipid binding|intracellular|organelle membrane|transport|anion binding|phospholipid binding|vesicle|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|establishment of protein localization|protein localization|cytoplasmic vesicle|phosphatidylinositol binding|protein transport|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|cytoplasmic vesicle membrane|phosphatidylinositol phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding - - - - 5:122843439-123029354 74 74 163 263 240 266 0.838601201851939 0.762137192222227 1.66541526880367 2.67039718532444 2.2315264532689 2.82508719797108 1.08871788762595 2.57567027885481 -1.24231775419384 9.85491151039812e-05 0.000781430353868328 DOWN ENSG00000183378 OVCH2 ovochymase 2 (gene/pseudogene) [Source:HGNC Symbol;Acc:HGNC:29970] GO:0008152|GO:0003824|GO:0071704|GO:0016787|GO:0008233|GO:0019538|GO:0017171|GO:0006508|GO:0008236|GO:0004252|GO:0004175 metabolic process|catalytic activity|organic substance metabolic process|hydrolase activity|peptidase activity|protein metabolic process|serine hydrolase activity|proteolysis|serine-type peptidase activity|serine-type endopeptidase activity|endopeptidase activity - - - - 11:7689438-7706421 0 0 0 5 4 8 0 0 0 0.129759297267875 0.0950600604584534 0.21718119564789 0 0.147333517791406 -Inf 9.86773759634038e-05 0.000782239612854875 DOWN ENSG00000174744 BRMS1 breast cancer metastasis suppressor 1 [Source:HGNC Symbol;Acc:HGNC:17262] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0010941|GO:0016570|GO:0034641|GO:0031325|GO:0046483|GO:0010942|GO:0043231|GO:0019213|GO:0019899|GO:0005737|GO:0016810|GO:0009890|GO:0006139|GO:0000790|GO:0044092|GO:0008134|GO:0008219|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051090|GO:0051276|GO:0032268|GO:0010468|GO:0034645|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0016811|GO:0070822|GO:0036211|GO:0031981|GO:0042826|GO:0051247|GO:0005654|GO:0043433|GO:0005694|GO:0033558|GO:0000228|GO:0051059|GO:0032270|GO:0012501|GO:0044267|GO:0010467|GO:0000118|GO:0051246|GO:0009059|GO:0043068|GO:0016070|GO:0016575|GO:0005634|GO:0043067|GO:0031401|GO:0043065|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0042981|GO:0032088|GO:0016568|GO:0006464|GO:0004407|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:1903507|GO:0090312|GO:0006357|GO:2000209|GO:1903506|GO:0090311|GO:0043276|GO:2000210|GO:0000122|GO:0006476 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|histone modification|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell death|intracellular membrane-bounded organelle|deacetylase activity|enzyme binding|cytoplasm|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|nuclear chromatin|negative regulation of molecular function|transcription factor binding|cell death|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|chromosome organization|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|Sin3-type complex|protein modification process|nuclear lumen|histone deacetylase binding|positive regulation of protein metabolic process|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|chromosome|protein deacetylase activity|nuclear chromosome|NF-kappaB binding|positive regulation of cellular protein metabolic process|programmed cell death|cellular protein metabolic process|gene expression|histone deacetylase complex|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of programmed cell death|RNA metabolic process|histone deacetylation|nucleus|regulation of programmed cell death|positive regulation of protein modification process|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of apoptotic process|negative regulation of NF-kappaB transcription factor activity|chromatin modification|cellular protein modification process|histone deacetylase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|positive regulation of protein deacetylation|regulation of transcription from RNA polymerase II promoter|regulation of anoikis|regulation of nucleic acid-templated transcription|regulation of protein deacetylation|anoikis|positive regulation of anoikis|negative regulation of transcription from RNA polymerase II promoter|protein deacetylation - - - - 11:66337333-66345125 2101 2374 1257 1124 1159 683 29.2670618399477 30.054792769527 15.7871029513049 14.0286935715314 13.246597104332 8.9166750590319 25.0363191869265 12.0639885782984 1.05331550653304 9.93151759172335e-05 0.000787086610521128 UP ENSG00000105483 CARD8 caspase recruitment domain family member 8 [Source:HGNC Symbol;Acc:HGNC:17057] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0042802|GO:0060341|GO:0006810|GO:0010941|GO:0043028|GO:0008047|GO:0032940|GO:0031325|GO:0010942|GO:0001817|GO:0043231|GO:0005737|GO:0001816|GO:0032880|GO:0051222|GO:0009966|GO:0046983|GO:0045184|GO:0001819|GO:0019904|GO:0010646|GO:0043085|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0051047|GO:0050790|GO:0019538|GO:0031323|GO:0061702|GO:0032268|GO:0005829|GO:0016504|GO:0051345|GO:0051223|GO:0051604|GO:0015031|GO:0070201|GO:0050714|GO:0050715|GO:0051046|GO:0031981|GO:0009306|GO:0051247|GO:0006508|GO:0005654|GO:0050663|GO:0032270|GO:0012501|GO:0035556|GO:0044267|GO:0008656|GO:0010467|GO:0032089|GO:0046903|GO:1902532|GO:0051246|GO:0043068|GO:0050707|GO:1902531|GO:0005634|GO:0042803|GO:0043067|GO:0032652|GO:0072559|GO:0032732|GO:0016505|GO:0043124|GO:0043122|GO:0032651|GO:0043065|GO:0016485|GO:0032731|GO:0030162|GO:0045862|GO:0050708|GO:0052547|GO:0032611|GO:0007249|GO:0050716|GO:0042981|GO:0050701|GO:0010952|GO:0006915|GO:0010950|GO:0050706|GO:0043281|GO:0031638|GO:0043280|GO:0050702|GO:0006919|GO:0050718|GO:0052548|GO:2001056|GO:2000116|GO:0097202 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|protein complex|regulation of metabolic process|identical protein binding|regulation of cellular localization|transport|regulation of cell death|cysteine-type endopeptidase regulator activity involved in apoptotic process|enzyme activator activity|secretion by cell|positive regulation of cellular metabolic process|positive regulation of cell death|regulation of cytokine production|intracellular membrane-bounded organelle|cytoplasm|cytokine production|regulation of protein localization|positive regulation of protein transport|regulation of signal transduction|protein dimerization activity|establishment of protein localization|positive regulation of cytokine production|protein domain specific binding|regulation of cell communication|positive regulation of catalytic activity|protein localization|cell communication|signal transduction|negative regulation of signal transduction|cell death|positive regulation of secretion|regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|inflammasome complex|regulation of cellular protein metabolic process|cytosol|peptidase activator activity|positive regulation of hydrolase activity|regulation of protein transport|protein maturation|protein transport|regulation of establishment of protein localization|positive regulation of protein secretion|positive regulation of cytokine secretion|regulation of secretion|nuclear lumen|protein secretion|positive regulation of protein metabolic process|proteolysis|nucleoplasm|cytokine secretion|positive regulation of cellular protein metabolic process|programmed cell death|intracellular signal transduction|cellular protein metabolic process|cysteine-type endopeptidase activator activity involved in apoptotic process|gene expression|NACHT domain binding|secretion|negative regulation of intracellular signal transduction|regulation of protein metabolic process|positive regulation of programmed cell death|regulation of cytokine secretion|regulation of intracellular signal transduction|nucleus|protein homodimerization activity|regulation of programmed cell death|regulation of interleukin-1 production|NLRP3 inflammasome complex|positive regulation of interleukin-1 production|peptidase activator activity involved in apoptotic process|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of I-kappaB kinase/NF-kappaB signaling|regulation of interleukin-1 beta production|positive regulation of apoptotic process|protein processing|positive regulation of interleukin-1 beta production|regulation of proteolysis|positive regulation of proteolysis|regulation of protein secretion|regulation of peptidase activity|interleukin-1 beta production|I-kappaB kinase/NF-kappaB signaling|positive regulation of interleukin-1 secretion|regulation of apoptotic process|interleukin-1 secretion|positive regulation of peptidase activity|apoptotic process|positive regulation of endopeptidase activity|regulation of interleukin-1 beta secretion|regulation of cysteine-type endopeptidase activity involved in apoptotic process|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|interleukin-1 beta secretion|activation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of interleukin-1 beta secretion|regulation of endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity K12801 caspase recruitment domain-containing protein 8[-] hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) 19:48180770-48255946 71 97 81 198 163 236 0.156663387692335 0.194519269022634 0.161140911499453 0.391445504668693 0.295097560728184 0.488034511764699 0.170774522738141 0.391525859053859 -1.1970148358256 9.97516983729473e-05 0.00078979869000525 DOWN ENSG00000273759 RP4-563E14.1 - - - - - - - 20:62928621-62929297 35 36 55 18 21 10 3.65697798317448 3.41852714157533 5.18123004030818 1.68506828465433 1.80030234435894 0.979214136672944 4.08557838835266 1.4881949218954 1.45697683150113 0.000100501005881171 0.000795428692888783 UP ENSG00000006016 CRLF1 cytokine receptor-like factor 1 [Source:HGNC Symbol;Acc:HGNC:2364] GO:0032502|GO:0032991|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0097058|GO:0071704|GO:0044237|GO:0023051|GO:0009893|GO:0005615|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0001822|GO:0009888|GO:0035295|GO:0010941|GO:0007275|GO:0048513|GO:0005102|GO:0031325|GO:0009966|GO:0046983|GO:0060548|GO:0010646|GO:0007154|GO:0007165|GO:0019955|GO:0008219|GO:0009967|GO:0019538|GO:0031323|GO:1902533|GO:0032268|GO:0005126|GO:1901215|GO:0043412|GO:0072164|GO:0001655|GO:0043069|GO:0046982|GO:0070997|GO:0005125|GO:0036211|GO:0072001|GO:0051247|GO:1901214|GO:0032270|GO:0012501|GO:0060429|GO:0006796|GO:0035556|GO:0072073|GO:0044267|GO:0051174|GO:0051246|GO:0001823|GO:1902531|GO:0043067|GO:0031401|GO:0001657|GO:0043523|GO:0072163|GO:0016310|GO:0005127|GO:0042981|GO:0043066|GO:0051402|GO:0043524|GO:0006464|GO:0006915|GO:2000671|GO:0007259|GO:2000672|GO:0097049|GO:0006468|GO:0046425|GO:0042325|GO:0001932|GO:0018193|GO:0046427|GO:0001934|GO:0042327|GO:0050731|GO:0050730|GO:0007260|GO:0042531|GO:0018108|GO:0042516|GO:0042517|GO:0042503 developmental process|macromolecular complex|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|CRLF-CLCF1 complex|organic substance metabolic process|cellular metabolic process|regulation of signaling|positive regulation of metabolic process|extracellular space|protein binding|protein complex|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|kidney development|tissue development|tube development|regulation of cell death|multicellular organism development|animal organ development|receptor binding|positive regulation of cellular metabolic process|regulation of signal transduction|protein dimerization activity|negative regulation of cell death|regulation of cell communication|cell communication|signal transduction|cytokine binding|cell death|positive regulation of signal transduction|protein metabolic process|regulation of cellular metabolic process|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytokine receptor binding|negative regulation of neuron death|macromolecule modification|mesonephric tubule development|urogenital system development|negative regulation of programmed cell death|protein heterodimerization activity|neuron death|cytokine activity|protein modification process|renal system development|positive regulation of protein metabolic process|regulation of neuron death|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|kidney epithelium development|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|mesonephros development|regulation of intracellular signal transduction|regulation of programmed cell death|positive regulation of protein modification process|ureteric bud development|regulation of neuron apoptotic process|mesonephric epithelium development|phosphorylation|ciliary neurotrophic factor receptor binding|regulation of apoptotic process|negative regulation of apoptotic process|neuron apoptotic process|negative regulation of neuron apoptotic process|cellular protein modification process|apoptotic process|regulation of motor neuron apoptotic process|JAK-STAT cascade|negative regulation of motor neuron apoptotic process|motor neuron apoptotic process|protein phosphorylation|regulation of JAK-STAT cascade|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of JAK-STAT cascade|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|tyrosine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|peptidyl-tyrosine phosphorylation|regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|tyrosine phosphorylation of Stat3 protein - - - - 19:18572220-18607741 77 68 74 40 33 32 1.44936568928415 1.16326145326682 1.25583883742664 0.674606169787478 0.509652158434956 0.564509291934163 1.28948865999254 0.582922540052199 1.14542299286358 0.000101320153751422 0.000801699408983551 UP ENSG00000112419 PHACTR2 phosphatase and actin regulator 2 [Source:HGNC Symbol;Acc:HGNC:20956] GO:0016020|GO:0008152|GO:0005488|GO:0009892|GO:0030234|GO:0005515|GO:0019222|GO:0004857|GO:0019208|GO:0044092|GO:0008092|GO:0050790|GO:0043086|GO:0003779|GO:0019212|GO:0019888|GO:0004864 membrane|metabolic process|binding|negative regulation of metabolic process|enzyme regulator activity|protein binding|regulation of metabolic process|enzyme inhibitor activity|phosphatase regulator activity|negative regulation of molecular function|cytoskeletal protein binding|regulation of catalytic activity|negative regulation of catalytic activity|actin binding|phosphatase inhibitor activity|protein phosphatase regulator activity|protein phosphatase inhibitor activity - - - - 6:143536845-143831185 25 15 46 72 92 90 0.102340188954136 0.0558067104076338 0.169775673813373 0.264079464772454 0.308998384479346 0.345283146310709 0.109307524391714 0.30612033185417 -1.48570615365931 0.000101490348958704 0.000802408071454752 DOWN ENSG00000272367 CTC-428H11.2 - - - - - - - 5:87376256-87377180 3 3 5 15 17 23 0.229441966831291 0.208532249616301 0.344710146818053 1.02776295134757 1.06666812917996 1.64841480425808 0.260894787755215 1.24761529492854 -2.25763311750497 0.000101479822199203 0.000802408071454752 DOWN ENSG00000275740 RP11-449H3.3 - GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043169|GO:0006139|GO:0000166|GO:0046872|GO:0003723|GO:0010467|GO:0016070|GO:0006396|GO:0016071|GO:0006397 cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cation binding|nucleobase-containing compound metabolic process|nucleotide binding|metal ion binding|RNA binding|gene expression|RNA metabolic process|RNA processing|mRNA metabolic process|mRNA processing - - - - 5:146203550-146339251 3 5 17 46 33 26 0.064099613204151 0.0970905874518929 0.327451981204247 0.880516757321143 0.578457508728048 0.520580166134665 0.162880727286764 0.659851477394619 -2.01832542374957 0.000101446183136603 0.000802408071454752 DOWN ENSG00000258976 CTD-2207P18.2 - - - - - - - 14:74614693-74616647 6 9 12 30 29 32 0.334174313140937 0.455603262495666 0.602627262961072 1.4971350078685 1.32525828536227 1.67041410951857 0.464134946199225 1.49760246758311 -1.69003848533108 0.000102552546939664 0.000809733863088266 DOWN ENSG00000258469 CHMP4BP1 charged multivesicular body protein 4B pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43616] - - - - - - 14:55298644-55299231 14 8 10 2 2 1 1.68424513983539 0.874657171143802 1.08466074824343 0.215581131315764 0.197395125543829 0.112730859485915 1.21452101974087 0.175235705448503 2.79301879016347 0.00010394347511898 0.000819632463339149 UP ENSG00000267218 AC005336.5 - - - - - - - 19:15902300-15903238 15 14 17 5 3 4 1.12996440329811 0.958490126844487 1.15462567600347 0.337457086185464 0.185443622368609 0.282367392450343 1.08102673538202 0.268422700334805 2.00982361388516 0.000104573358609611 0.000824163951407422 UP ENSG00000263826 RP11-573D15.9 - - - - - - - 3:186781780-186784179 54 73 67 29 34 29 1.59158799251984 1.95541811517914 1.7804289005205 0.76583861103841 0.822199132347493 0.801040902585429 1.77581166940649 0.796359548657111 1.15698674143995 0.000104719708443853 0.000825064837789027 UP ENSG00000274877 RP11-65I12.1 - - - - - - - 2:113237595-113240825 85 95 104 233 181 224 1.86092572728693 1.89022721206112 2.05283725242866 4.57049141776606 3.25128775225967 4.59605088211678 1.9346633972589 4.1392766840475 -1.09729610602393 0.000104800223888088 0.000825298307558686 DOWN ENSG00000257497 RP11-585P4.5 - - - - - - - 12:75483454-75489820 14 15 22 5 5 4 0.668243010946834 0.650701724591034 0.946727662330607 0.213813902785527 0.195816393538391 0.178908894406796 0.755224132622825 0.196179730243571 1.94472887910465 0.000105269360092581 0.0008287741234715 UP ENSG00000116833 NR5A2 nuclear receptor subfamily 5 group A member 2 [Source:HGNC Symbol;Acc:HGNC:7984] GO:0032502|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0004872|GO:0003700|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0009653|GO:0043227|GO:0008289|GO:0004879|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0098531|GO:0042127|GO:0006725|GO:0003707|GO:0009888|GO:1901360|GO:0006082|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0005543|GO:0048524|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0000981|GO:0009887|GO:0005667|GO:0042592|GO:0031018|GO:0003682|GO:0006139|GO:0007154|GO:0006629|GO:0007165|GO:0009725|GO:0031016|GO:0048869|GO:0044249|GO:0050792|GO:0010033|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0044798|GO:0048878|GO:0051252|GO:0009790|GO:0010628|GO:0003705|GO:0035270|GO:0031981|GO:0005654|GO:0008202|GO:0014070|GO:0060429|GO:1903902|GO:0010467|GO:0019079|GO:0019058|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0009755|GO:0001228|GO:0008206|GO:0061113|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0030522|GO:0043401|GO:0000975|GO:0045893|GO:0030855|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0045069|GO:0071383|GO:0071407|GO:0003690|GO:0045070|GO:0046914|GO:0019752|GO:0090575|GO:0055088|GO:0071396|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006352|GO:0006357|GO:1903506|GO:0044212|GO:0032787|GO:0008270|GO:0055092|GO:0006367|GO:0035326|GO:0000976|GO:0001012|GO:0001159|GO:0042632|GO:0000977|GO:0000987|GO:0001158|GO:0000980|GO:0000978 developmental process|macromolecular complex|signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|transcription factor activity, sequence-specific DNA binding|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|anatomical structure morphogenesis|membrane-bounded organelle|lipid binding|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|viral process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|regulation of cell proliferation|cellular aromatic compound metabolic process|steroid hormone receptor activity|tissue development|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|phospholipid binding|positive regulation of viral process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|organ morphogenesis|transcription factor complex|homeostatic process|endocrine pancreas development|chromatin binding|nucleobase-containing compound metabolic process|cell communication|lipid metabolic process|signal transduction|response to hormone|pancreas development|cellular developmental process|cellular biosynthetic process|regulation of viral process|response to organic substance|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|nuclear transcription factor complex|chemical homeostasis|regulation of RNA metabolic process|embryo development|positive regulation of gene expression|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|endocrine system development|nuclear lumen|nucleoplasm|steroid metabolic process|response to organic cyclic compound|epithelium development|positive regulation of viral life cycle|gene expression|viral genome replication|viral life cycle|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|bile acid metabolic process|pancreas morphogenesis|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|regulatory region DNA binding|positive regulation of transcription, DNA-templated|epithelial cell differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of viral genome replication|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|positive regulation of viral genome replication|transition metal ion binding|carboxylic acid metabolic process|RNA polymerase II transcription factor complex|lipid homeostasis|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|monocarboxylic acid metabolic process|zinc ion binding|sterol homeostasis|transcription initiation from RNA polymerase II promoter|enhancer binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|cholesterol homeostasis|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|enhancer sequence-specific DNA binding|RNA polymerase II distal enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K08027 nuclear receptor subfamily 5 group A member 2[-] hsa04950 Maturity onset diabetes of the young - Homo sapiens (human) 1:200027602-200177424 34 44 61 87 133 134 0.177443829285481 0.208694207723112 0.287026785396851 0.406815248728383 0.569506887400744 0.655409336625399 0.224388274135148 0.543910490918175 -1.27737196574298 0.000105698579383001 0.000831933927998978 DOWN ENSG00000134548 SPX spexin hormone [Source:HGNC Symbol;Acc:HGNC:28139] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0051051|GO:0044237|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0003014|GO:0006725|GO:0006810|GO:1901360|GO:0009991|GO:0050877|GO:0005102|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0043231|GO:0030133|GO:0005737|GO:0032098|GO:0042592|GO:0006139|GO:0035814|GO:2000021|GO:0007588|GO:0008217|GO:0051048|GO:0002027|GO:0032094|GO:0044249|GO:0010876|GO:0031323|GO:0003013|GO:0010468|GO:0034645|GO:0032099|GO:0031410|GO:0048878|GO:0051252|GO:0005179|GO:0035813|GO:0044062|GO:0010628|GO:0016023|GO:0010459|GO:0006811|GO:0007600|GO:0051046|GO:0045777|GO:0006869|GO:0031644|GO:0031988|GO:0001664|GO:0032095|GO:0045822|GO:0010467|GO:0046903|GO:0031328|GO:0009059|GO:0016070|GO:0031667|GO:0008015|GO:0010557|GO:0003073|GO:0008016|GO:0045893|GO:0006820|GO:0015711|GO:0005184|GO:0019233|GO:0032774|GO:0060047|GO:0071855|GO:2001141|GO:0015908|GO:0003084|GO:0046942|GO:0050801|GO:0006351|GO:0006355|GO:0015718|GO:0045944|GO:0006366|GO:0051930|GO:0006357|GO:1903506|GO:0015909|GO:0055065|GO:0031766|GO:0031765|GO:0044539|GO:0055078 cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|negative regulation of transport|cellular metabolic process|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|extracellular space|intracellular|protein binding|endomembrane system|regulation of metabolic process|renal system process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|response to extracellular stimulus|neurological system process|receptor binding|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|regulation of appetite|homeostatic process|nucleobase-containing compound metabolic process|negative regulation of renal sodium excretion|regulation of ion homeostasis|excretion|regulation of blood pressure|negative regulation of secretion|regulation of heart rate|response to food|cellular biosynthetic process|lipid localization|regulation of cellular metabolic process|circulatory system process|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of appetite|cytoplasmic vesicle|chemical homeostasis|regulation of RNA metabolic process|hormone activity|regulation of renal sodium excretion|regulation of excretion|positive regulation of gene expression|cytoplasmic, membrane-bounded vesicle|negative regulation of heart rate|ion transport|sensory perception|regulation of secretion|positive regulation of blood pressure|lipid transport|regulation of neurological system process|membrane-bounded vesicle|G-protein coupled receptor binding|regulation of response to food|negative regulation of heart contraction|gene expression|secretion|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|response to nutrient levels|blood circulation|positive regulation of macromolecule biosynthetic process|regulation of systemic arterial blood pressure|regulation of heart contraction|positive regulation of transcription, DNA-templated|anion transport|organic anion transport|neuropeptide hormone activity|sensory perception of pain|RNA biosynthetic process|heart contraction|neuropeptide receptor binding|regulation of RNA biosynthetic process|fatty acid transport|positive regulation of systemic arterial blood pressure|carboxylic acid transport|ion homeostasis|transcription, DNA-templated|regulation of transcription, DNA-templated|monocarboxylic acid transport|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of sensory perception of pain|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|long-chain fatty acid transport|metal ion homeostasis|type 3 galanin receptor binding|type 2 galanin receptor binding|long-chain fatty acid import|sodium ion homeostasis - - - - 12:21526307-21537377 5 7 3 0 0 0 0.0589403341468545 0.0749944241312042 0.0318781506104435 0 0 0 0.0552709696295007 0 Inf 0.000106302245993576 0.000836244335149461 UP ENSG00000280387 RP5-1153D9.5 - - - - - - - 20:56522252-56523499 15 20 8 0 3 5 0.850189563058433 1.03024522562611 0.408833666645599 0 0.139528494714843 0.2656243939415 0.763089485110047 0.135050962885448 2.49834832130085 0.000106345032444713 0.000836360537040166 UP ENSG00000196503 ARL9 ADP ribosylation factor like GTPase 9 [Source:HGNC Symbol;Acc:HGNC:23592] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0005622|GO:0043168|GO:0001882|GO:0007154|GO:0007165|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0035556|GO:0017076|GO:0032561|GO:0005525|GO:0007264|GO:0019001 signaling|cell|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|intracellular|anion binding|nucleoside binding|cell communication|signal transduction|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding - - - - 4:56505343-56524448 12 4 6 0 1 0 0.674776642549188 0.204411135386548 0.304187847361114 0 0.0461551888587857 0 0.394458541765617 0.0153850629529286 4.68027142656439 0.00010641569838528 0.000836695880851765 UP ENSG00000270571 RP11-355F16.1 - - - - - - - 2:75154366-75189949 3 7 6 24 22 20 0.0617317682719441 0.130902134732797 0.111305500866865 0.442430582999415 0.371398462686258 0.385647452313893 0.101313134623869 0.399825499333189 -1.98054926176985 0.000107075898226291 0.000841222069907291 DOWN ENSG00000186369 LINC00643 long intergenic non-protein coding RNA 643 [Source:HGNC Symbol;Acc:HGNC:44296] - - - - - - 14:62114353-62130962 2 3 8 17 16 31 0.0209923024033729 0.0286232869706304 0.0757121851867797 0.15988164938569 0.137795636134012 0.304962186334897 0.0417759248535943 0.200879823951533 -2.26558899660048 0.000107788818373703 0.000846154978629642 DOWN ENSG00000131470 PSMC3IP PSMC3 interacting protein [Source:HGNC Symbol;Acc:HGNC:17928] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0007049|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003713|GO:0003677|GO:0051252|GO:0006259|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0030374|GO:0006310|GO:1903506 reproduction|cell|cellular process|reproductive process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cell cycle|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|transcription coactivator activity|DNA binding|regulation of RNA metabolic process|DNA metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|ligand-dependent nuclear receptor transcription coactivator activity|DNA recombination|regulation of nucleic acid-templated transcription - - - - 17:42572315-42577831 371 363 227 179 180 112 4.366618582583 3.88291532102497 2.40886034730589 1.8876572323556 1.73824417636716 1.23542765392007 3.55279808363795 1.62044302088094 1.13256740571131 0.000108000371891115 0.000847592823984585 UP ENSG00000267632 RP11-400F19.18 - - - - - - - 17:42509784-42511519 0 3 1 8 12 11 0 0.11111309383357 0.0367192844584358 0.292077661782648 0.401191315822329 0.420053983816418 0.0492774594306686 0.371107653807132 -2.91283797293382 0.000110230446014314 0.00086463997249378 DOWN ENSG00000256690 RP11-727F15.9 - - - - - - - 11:62832234-62834043 24 22 15 8 5 4 1.51307644536975 1.26053533488372 0.852618008711082 0.451913387571014 0.258645182908998 0.236312817745876 1.20874326298818 0.315623796075296 1.93722996395028 0.000110578002844457 0.000867138349597695 UP ENSG00000203618 GP1BB glycoprotein Ib (platelet), beta polypeptide [Source:HGNC Symbol;Acc:HGNC:4440] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0006950|GO:0071704|GO:0038023|GO:0007155|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0042802|GO:0050817|GO:0005887|GO:0004888|GO:0009611|GO:0001775|GO:0031226|GO:0007597|GO:0072378|GO:0007154|GO:0007165|GO:0016021|GO:0019538|GO:0050878|GO:0030168|GO:0007166|GO:0007596|GO:0042060|GO:0007599 signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|response to stress|organic substance metabolic process|signaling receptor activity|cell adhesion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|identical protein binding|coagulation|integral component of plasma membrane|transmembrane signaling receptor activity|response to wounding|cell activation|intrinsic component of plasma membrane|blood coagulation, intrinsic pathway|blood coagulation, fibrin clot formation|cell communication|signal transduction|integral component of membrane|protein metabolic process|regulation of body fluid levels|platelet activation|cell surface receptor signaling pathway|blood coagulation|wound healing|hemostasis K06262 platelet glycoprotein Ib beta chain[-] hsa04611 Platelet activation - Homo sapiens (human) 22:19722945-19724771 13 12 14 6 0 1 0.592124564585058 0.496746699902662 0.574947023795228 0.244871291462336 0 0.0426823859483053 0.554606096094316 0.0958512258035471 2.53259468703266 0.000111090173852686 0.000870468779579551 UP ENSG00000180015 RP11-756P10.3 - - - - - - - 4:188738373-188739494 102 126 75 49 48 45 6.43061918489958 7.2194296452431 4.26314953406676 2.76788377933764 2.48290051312061 2.65883344540938 5.97106612140315 2.63653924595588 1.17934307270136 0.000113746964100611 0.00088979845203008 UP ENSG00000233232 NPIPB7 nuclear pore complex interacting protein family member B7 [Source:HGNC Symbol;Acc:HGNC:33832] GO:0005576 extracellular region - - - - 16:28456372-28471175 33 12 11 4 3 4 1.11369607285916 0.368057072971772 0.33469713634875 0.120955825585562 0.0830780350210516 0.126499514079615 0.605483427393227 0.110177791562076 2.45825402216762 0.000113900126904027 0.000890383448178273 UP ENSG00000116761 CTH cystathionine gamma-lyase [Source:HGNC Symbol;Acc:HGNC:2501] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0048037|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006575|GO:0016846|GO:0045595|GO:0006725|GO:1901360|GO:0010941|GO:0006082|GO:0007275|GO:0034641|GO:0043168|GO:0044281|GO:0031982|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0061061|GO:0045597|GO:0043231|GO:0005737|GO:0006520|GO:0009966|GO:0060548|GO:0010646|GO:0006139|GO:0005516|GO:0007154|GO:0007165|GO:0009968|GO:0070062|GO:0030170|GO:0008219|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0006790|GO:0051090|GO:1902533|GO:0005829|GO:0051149|GO:0010468|GO:0034645|GO:0030968|GO:0001944|GO:0043412|GO:0072358|GO:0044540|GO:0042692|GO:0043069|GO:2001234|GO:0051252|GO:0010628|GO:0051147|GO:0070813|GO:0036211|GO:0000096|GO:0051091|GO:0006986|GO:0009063|GO:0047982|GO:0050667|GO:0004123|GO:0008652|GO:0080146|GO:0006461|GO:0012501|GO:1901342|GO:0035556|GO:0044267|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0035967|GO:1902531|GO:0016070|GO:0072359|GO:0034976|GO:0010557|GO:0005634|GO:0043067|GO:0097190|GO:0034620|GO:0070814|GO:0045893|GO:0043122|GO:0051259|GO:1904831|GO:0051145|GO:0032774|GO:2001141|GO:0046395|GO:0051092|GO:0043123|GO:0007249|GO:0006534|GO:0042981|GO:0043066|GO:0019752|GO:0000098|GO:0009069|GO:0051150|GO:0019346|GO:0051152|GO:0006464|GO:0006351|GO:0006915|GO:0006355|GO:0000097|GO:0035886|GO:0019344|GO:1903506|GO:0018193|GO:0009070|GO:0044524|GO:0051260|GO:0051262|GO:0019343|GO:0018352|GO:0051289|GO:0018205|GO:0018272 developmental process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cofactor binding|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular modified amino acid metabolic process|carbon-sulfur lyase activity|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|calmodulin binding|cell communication|signal transduction|negative regulation of signal transduction|extracellular exosome|pyridoxal phosphate binding|cell death|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|sulfur compound metabolic process|regulation of sequence-specific DNA binding transcription factor activity|positive regulation of intracellular signal transduction|cytosol|positive regulation of muscle cell differentiation|regulation of gene expression|cellular macromolecule biosynthetic process|endoplasmic reticulum unfolded protein response|vasculature development|macromolecule modification|cardiovascular system development|L-cystine L-cysteine-lyase (deaminating)|muscle cell differentiation|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|positive regulation of gene expression|regulation of muscle cell differentiation|hydrogen sulfide metabolic process|protein modification process|sulfur amino acid metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|response to unfolded protein|cellular amino acid catabolic process|homocysteine desulfhydrase activity|homocysteine metabolic process|cystathionine gamma-lyase activity|cellular amino acid biosynthetic process|L-cysteine desulfhydrase activity|protein complex assembly|programmed cell death|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|cellular response to topologically incorrect protein|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|response to endoplasmic reticulum stress|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|apoptotic signaling pathway|cellular response to unfolded protein|hydrogen sulfide biosynthetic process|positive regulation of transcription, DNA-templated|regulation of I-kappaB kinase/NF-kappaB signaling|protein oligomerization|positive regulation of aortic smooth muscle cell differentiation|smooth muscle cell differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|carboxylic acid catabolic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|cysteine metabolic process|regulation of apoptotic process|negative regulation of apoptotic process|carboxylic acid metabolic process|sulfur amino acid catabolic process|serine family amino acid metabolic process|regulation of smooth muscle cell differentiation|transsulfuration|positive regulation of smooth muscle cell differentiation|cellular protein modification process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|sulfur amino acid biosynthetic process|vascular smooth muscle cell differentiation|cysteine biosynthetic process|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|serine family amino acid biosynthetic process|protein sulfhydration|protein homooligomerization|protein tetramerization|cysteine biosynthetic process via cystathionine|protein-pyridoxal-5-phosphate linkage|protein homotetramerization|peptidyl-lysine modification|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine K01758 cystathionine gamma-lyase[4.4.1.1] hsa01100|hsa01230|hsa00270|hsa00260|hsa00450 Metabolic pathways - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Cysteine and methionine metabolism - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human)|Selenocompound metabolism - Homo sapiens (human) 1:70411218-70439851 34 37 56 83 107 157 0.652488785169671 0.645323006398112 0.968937646083076 1.42714337244633 1.68477801667791 2.82371184008664 0.75558314588362 1.97854440973696 -1.38877702162583 0.000114553903109998 0.000894791267254287 DOWN ENSG00000170802 FOXN2 forkhead box N2 [Source:HGNC Symbol;Acc:HGNC:5281] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0061061|GO:0043231|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0060537|GO:0010467|GO:0009059|GO:0030154|GO:0007517|GO:0016070|GO:0005634|GO:0060538|GO:0032774|GO:0043565|GO:2001141|GO:0035914|GO:0014706|GO:0006351|GO:0006355|GO:0007519|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|muscle tissue development|gene expression|macromolecule biosynthetic process|cell differentiation|muscle organ development|RNA metabolic process|nucleus|skeletal muscle organ development|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|skeletal muscle cell differentiation|striated muscle tissue development|transcription, DNA-templated|regulation of transcription, DNA-templated|skeletal muscle tissue development|regulation of nucleic acid-templated transcription - - - - 2:48314637-48379294 501 417 666 198 201 386 5.21010562044673 3.94116956654364 6.24449395880589 1.84489267695809 1.71503266496584 3.76206137699466 5.13192304859875 2.44066223963953 1.07222688180701 0.000115010210720198 0.000897885677521124 UP ENSG00000237813 AC002066.1 - - - - - - - 7:116238260-116499465 1 0 2 8 10 9 0.058340225410234 0 0.105157546573312 0.418010569542191 0.478482926997355 0.491873227658586 0.0544992573278487 0.462788908066044 -3.0860458116935 0.000114981797858825 0.000897885677521124 DOWN ENSG00000235489 DBF4P1 DBF4 zinc finger pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:45059] - - - - - - 10:64168959-64170850 110 129 93 63 48 51 4.11259155869062 4.38324122244071 3.13487947400106 2.11037707119475 1.47241774615292 1.78699583232877 3.87690408504413 1.78993021655881 1.11500170043318 0.00011598441891442 0.000904545152108436 UP ENSG00000139405 RITA1 RBPJ interacting and tubulin associated 1 [Source:HGNC Symbol;Acc:HGNC:25925] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0051649|GO:0008092|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0015631|GO:0005813|GO:0010468|GO:0034645|GO:0007166|GO:0010629|GO:0051252|GO:0005815|GO:0046907|GO:0008593|GO:0010467|GO:0007399|GO:0009059|GO:0030154|GO:0016070|GO:0005856|GO:0005634|GO:0045746|GO:0051169|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0015630|GO:0007219|GO:0022008|GO:0006351|GO:0006355|GO:0006366|GO:0006913|GO:1903507|GO:0006357|GO:1903506|GO:0000122|GO:0051168 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|establishment of localization in cell|cytoskeletal protein binding|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|tubulin binding|centrosome|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|negative regulation of gene expression|regulation of RNA metabolic process|microtubule organizing center|intracellular transport|regulation of Notch signaling pathway|gene expression|nervous system development|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|cytoskeleton|nucleus|negative regulation of Notch signaling pathway|nuclear transport|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|microtubule cytoskeleton|Notch signaling pathway|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter|nuclear export - - - - 12:113185526-113192368 943 985 569 465 552 325 12.9952914463751 12.3364667488519 7.06969486362766 5.7414967134018 6.24139270319821 4.19745702011955 10.8004843529516 5.39344881223985 1.00181601533682 0.000116620964082699 0.000909034533087437 UP ENSG00000184678 HIST2H2BE histone cluster 2, H2be [Source:HGNC Symbol;Acc:HGNC:4760] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0097159|GO:0043229|GO:0006950|GO:0006955|GO:0000785|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005615|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0045087|GO:0006959|GO:0003676|GO:0006952|GO:0031982|GO:0022607|GO:0098542|GO:0043231|GO:0005737|GO:0046983|GO:0009617|GO:0000790|GO:0070062|GO:0019730|GO:0000786|GO:0006996|GO:0051276|GO:0003677|GO:0002385|GO:0046982|GO:0006325|GO:0000788|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0002227|GO:0042742|GO:0005634|GO:0019731|GO:0006334|GO:0034622|GO:0034728|GO:0006333|GO:0050830|GO:0065004|GO:0031497|GO:0071103|GO:0006323 macromolecular complex|immune system process|cell|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|response to stress|immune response|chromatin|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|extracellular space|protein-DNA complex|intracellular|protein binding|protein complex|innate immune response|humoral immune response|nucleic acid binding|defense response|vesicle|cellular component assembly|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|response to bacterium|nuclear chromatin|extracellular exosome|antimicrobial humoral response|nucleosome|organelle organization|chromosome organization|DNA binding|mucosal immune response|protein heterodimerization activity|chromatin organization|nuclear nucleosome|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|innate immune response in mucosa|defense response to bacterium|nucleus|antibacterial humoral response|nucleosome assembly|cellular macromolecular complex assembly|nucleosome organization|chromatin assembly or disassembly|defense response to Gram-positive bacterium|protein-DNA complex assembly|chromatin assembly|DNA conformation change|DNA packaging K11252 histone H2B[-] - - 1:149842204-149886652 28 28 69 126 138 90 0.750798340977073 0.682351955350245 1.66815218545968 3.02719141607771 3.03610239791685 2.2617485853863 1.033767493929 2.77501413312695 -1.42458337550891 0.000116816833627296 0.000910323610313052 DOWN ENSG00000234695 AC002076.10 - - - - - - - 7:93890913-93893601 0 0 0 4 6 6 0 0 0 0.48106908999495 0.660730553053728 0.75481022583816 0 0.632203289628946 -Inf 0.000117088499917276 0.000912202525190593 DOWN ENSG00000239521 GATS GATS, stromal antigen 3 opposite strand [Source:HGNC Symbol;Acc:HGNC:29954] - - - - - - 7:100200653-100272218 244 322 536 742 679 954 1.9791061220891 2.3736396364477 3.91975325554866 5.39238501077517 4.51873660985413 7.25198595151227 2.75749967136182 5.72103585738052 -1.05291567281351 0.000117141191536168 0.000912374936634691 DOWN ENSG00000123191 ATP7B ATPase, Cu++ transporting, beta polypeptide [Source:HGNC Symbol;Acc:HGNC:870] GO:0032502|GO:0005215|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0007623|GO:0043167|GO:0051641|GO:0005911|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0016323|GO:0006810|GO:0007275|GO:0048513|GO:0043168|GO:0001882|GO:0031982|GO:0016817|GO:0005887|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0042592|GO:0019725|GO:0022891|GO:0031226|GO:0055085|GO:0051649|GO:0000166|GO:0051238|GO:0016021|GO:0010035|GO:0010033|GO:0043296|GO:0048732|GO:0050878|GO:0005794|GO:0005768|GO:0016820|GO:0030879|GO:0005802|GO:0046872|GO:0014074|GO:0035639|GO:0007589|GO:0031410|GO:0048878|GO:0046683|GO:0001883|GO:0051208|GO:0010038|GO:0016023|GO:0016818|GO:0046907|GO:0006811|GO:0032549|GO:0055082|GO:0015075|GO:0005770|GO:0048471|GO:0031988|GO:0046688|GO:0005739|GO:0051591|GO:0007595|GO:0014070|GO:0010043|GO:0046903|GO:0000139|GO:0017076|GO:0005923|GO:0034220|GO:0015680|GO:0098655|GO:0005524|GO:0006812|GO:0030554|GO:0042625|GO:0046914|GO:0050801|GO:0042626|GO:0016462|GO:0006873|GO:0008324|GO:0019829|GO:0005507|GO:0017111|GO:0022890|GO:0030001|GO:0008270|GO:0030003|GO:0016887|GO:0043682|GO:0055065|GO:0006875|GO:0035434|GO:0046873|GO:0006882|GO:0046915|GO:0055069|GO:0042623|GO:0006874|GO:0060003|GO:0055074|GO:0004008|GO:0006825|GO:0006878|GO:0005375|GO:0015677|GO:0043492|GO:0055070 developmental process|transporter activity|cell|rhythmic process|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|circadian rhythm|ion binding|cellular localization|cell-cell junction|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|basolateral plasma membrane|transport|multicellular organism development|animal organ development|anion binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|establishment of localization in cell|nucleotide binding|sequestering of metal ion|integral component of membrane|response to inorganic substance|response to organic substance|apical junction complex|gland development|regulation of body fluid levels|Golgi apparatus|endosome|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|mammary gland development|trans-Golgi network|metal ion binding|response to purine-containing compound|purine ribonucleoside triphosphate binding|body fluid secretion|cytoplasmic vesicle|chemical homeostasis|response to organophosphorus|purine nucleoside binding|sequestering of calcium ion|response to metal ion|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ion transport|ribonucleoside binding|cellular chemical homeostasis|ion transmembrane transporter activity|late endosome|perinuclear region of cytoplasm|membrane-bounded vesicle|response to copper ion|mitochondrion|response to cAMP|lactation|response to organic cyclic compound|response to zinc ion|secretion|Golgi membrane|purine nucleotide binding|bicellular tight junction|ion transmembrane transport|intracellular copper ion transport|cation transmembrane transport|ATP binding|cation transport|adenyl nucleotide binding|ATPase coupled ion transmembrane transporter activity|transition metal ion binding|ion homeostasis|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|cellular ion homeostasis|cation transmembrane transporter activity|cation-transporting ATPase activity|copper ion binding|nucleoside-triphosphatase activity|inorganic cation transmembrane transporter activity|metal ion transport|zinc ion binding|cellular cation homeostasis|ATPase activity|copper-transporting ATPase activity|metal ion homeostasis|cellular metal ion homeostasis|copper ion transmembrane transport|metal ion transmembrane transporter activity|cellular zinc ion homeostasis|transition metal ion transmembrane transporter activity|zinc ion homeostasis|ATPase activity, coupled|cellular calcium ion homeostasis|copper ion export|calcium ion homeostasis|copper-exporting ATPase activity|copper ion transport|cellular copper ion homeostasis|copper ion transmembrane transporter activity|copper ion import|ATPase activity, coupled to movement of substances|copper ion homeostasis - - - - 13:51930436-52012125 41 44 93 147 141 167 0.151551535415531 0.147810069053616 0.30993321653394 0.486842075625777 0.427620300313987 0.578519611908186 0.203098273667696 0.497660662615983 -1.29298437748106 0.000117952376235795 0.000918453375102618 DOWN ENSG00000186364 NUDT17 nudix hydrolase 17 [Source:HGNC Symbol;Acc:HGNC:26618] GO:0008152|GO:0005488|GO:0003824|GO:0043167|GO:0016787|GO:0043169|GO:0046872 metabolic process|binding|catalytic activity|ion binding|hydrolase activity|cation binding|metal ion binding - - - - 1:145845629-145848953 59 49 47 23 9 25 1.45012017592564 1.09454768121344 1.04151088301422 0.506507140671013 0.181492898840667 0.57587046028289 1.19539291338443 0.42129016659819 1.50459874798353 0.000118308281327086 0.000920984466946241 UP ENSG00000107831 FGF8 fibroblast growth factor 8 [Source:HGNC Symbol;Acc:HGNC:3686] GO:0040011|GO:0032502|GO:0040007|GO:0000003|GO:0002376|GO:0023052|GO:0042056|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0031128|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0006955|GO:0009986|GO:0044237|GO:0003006|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0045927|GO:0071944|GO:0040008|GO:0009605|GO:0009893|GO:0009058|GO:0005615|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0045137|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0006935|GO:0021544|GO:0045087|GO:0009897|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0048839|GO:0001568|GO:0010941|GO:0007275|GO:0030324|GO:0060411|GO:0048513|GO:0051302|GO:0072028|GO:0005102|GO:0034641|GO:0046620|GO:0006952|GO:0030900|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0035265|GO:0061061|GO:0048608|GO:0048635|GO:0010243|GO:0048853|GO:0007389|GO:0001763|GO:0060322|GO:0007423|GO:0006928|GO:0009887|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0072006|GO:0048568|GO:0007548|GO:0048771|GO:0048639|GO:0045787|GO:0030323|GO:0006979|GO:0060548|GO:0042493|GO:1901862|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0001525|GO:0008406|GO:0007154|GO:0046622|GO:0016477|GO:0007165|GO:0003151|GO:0048382|GO:0048638|GO:0003279|GO:0061351|GO:0009725|GO:0030916|GO:0008219|GO:0048645|GO:0060348|GO:0021543|GO:0050790|GO:0030030|GO:0051781|GO:0051301|GO:0001759|GO:0048869|GO:0048806|GO:0030917|GO:0021537|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0021536|GO:0048732|GO:0021984|GO:0003272|GO:0006996|GO:0003205|GO:0071774|GO:0000165|GO:0060425|GO:1902533|GO:0032268|GO:0090133|GO:0000902|GO:0031175|GO:0003143|GO:0010468|GO:0090132|GO:0071773|GO:0034645|GO:0003156|GO:1901215|GO:0090068|GO:0007166|GO:0002009|GO:0070851|GO:0001569|GO:1903047|GO:0001944|GO:0043412|GO:0046661|GO:0072164|GO:0061458|GO:0072358|GO:0003148|GO:0007417|GO:0001655|GO:0030539|GO:0043583|GO:0007498|GO:0043069|GO:0051252|GO:0060541|GO:0035050|GO:0048738|GO:0003007|GO:0070997|GO:0048754|GO:1901652|GO:0007492|GO:0061138|GO:0022612|GO:0000904|GO:0009790|GO:0071417|GO:0001656|GO:0010628|GO:0030878|GO:0001667|GO:0051347|GO:0036211|GO:0000278|GO:0060840|GO:0060537|GO:0007369|GO:0048844|GO:0060037|GO:0021871|GO:2000027|GO:0072001|GO:0045843|GO:0021983|GO:0042472|GO:0003002|GO:0007431|GO:0021532|GO:0060485|GO:0035270|GO:0060128|GO:0016331|GO:0023019|GO:0007346|GO:0043434|GO:0044344|GO:0010564|GO:0051247|GO:0070848|GO:0021846|GO:0061371|GO:0010092|GO:0003198|GO:0002764|GO:0035272|GO:1901214|GO:0001974|GO:0061326|GO:0021872|GO:0032270|GO:0060993|GO:0012501|GO:0003197|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0072073|GO:0042476|GO:0033043|GO:0035108|GO:0044267|GO:0051174|GO:0007067|GO:0048864|GO:0010467|GO:0050918|GO:0032990|GO:0048854|GO:0048562|GO:0007399|GO:0060562|GO:0060129|GO:0071310|GO:0097485|GO:0051246|GO:0071599|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0001823|GO:0060173|GO:0007517|GO:1902531|GO:0016070|GO:0045931|GO:0008083|GO:0072359|GO:0032870|GO:0043067|GO:0045165|GO:0016202|GO:0010638|GO:0048666|GO:0030182|GO:0007411|GO:0016055|GO:0071600|GO:0001840|GO:0021953|GO:0055024|GO:0021798|GO:0048863|GO:0060317|GO:0009792|GO:0031401|GO:0008543|GO:0042481|GO:0005104|GO:0001657|GO:0030855|GO:1901653|GO:0043408|GO:0043523|GO:0021903|GO:0007088|GO:0032774|GO:2001141|GO:0072078|GO:0014031|GO:0071363|GO:0090134|GO:0072163|GO:0016310|GO:0001658|GO:0002768|GO:0038179|GO:0070371|GO:0001839|GO:0061564|GO:0001947|GO:0048017|GO:0060445|GO:0042471|GO:0030509|GO:0061333|GO:0007167|GO:0009855|GO:0021954|GO:0071375|GO:0009953|GO:0043410|GO:0035909|GO:0072080|GO:0042981|GO:0009952|GO:0045840|GO:0035904|GO:0043066|GO:0042475|GO:0032868|GO:0048762|GO:0007435|GO:0051402|GO:0021879|GO:0043524|GO:0014706|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0042074|GO:0048812|GO:0035137|GO:0001837|GO:0030326|GO:0008078|GO:0043549|GO:0006351|GO:0003203|GO:0006915|GO:0006355|GO:0033674|GO:0055026|GO:0048011|GO:0033563|GO:0035116|GO:0000186|GO:0006366|GO:0007265|GO:0045859|GO:0048015|GO:0045860|GO:0006357|GO:0007409|GO:0005111|GO:0006468|GO:0008045|GO:0048699|GO:0007368|GO:1903506|GO:0060070|GO:0043405|GO:0042325|GO:0070374|GO:0001932|GO:0032869|GO:0060675|GO:0038093|GO:0043009|GO:0021884|GO:0042487|GO:0001934|GO:0007178|GO:0005105|GO:0070372|GO:0042327|GO:0071542|GO:0007169|GO:0048010|GO:0002067|GO:0038095|GO:0060563|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0061101 locomotion|developmental process|growth|reproduction|immune system process|signaling|chemoattractant activity|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|developmental induction|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|immune response|cell surface|cellular metabolic process|developmental process involved in reproduction|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|cell periphery|regulation of growth|response to external stimulus|positive regulation of metabolic process|biosynthetic process|extracellular space|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|development of primary sexual characteristics|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|chemotaxis|subpallium development|innate immune response|external side of plasma membrane|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|inner ear development|blood vessel development|regulation of cell death|multicellular organism development|lung development|cardiac septum morphogenesis|animal organ development|regulation of cell division|nephron morphogenesis|receptor binding|cellular nitrogen compound metabolic process|regulation of organ growth|defense response|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|organ growth|muscle structure development|reproductive structure development|negative regulation of muscle organ development|response to organonitrogen compound|forebrain morphogenesis|pattern specification process|morphogenesis of a branching structure|head development|sensory organ development|movement of cell or subcellular component|organ morphogenesis|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|nephron development|embryonic organ development|sex differentiation|tissue remodeling|positive regulation of developmental growth|positive regulation of cell cycle|respiratory tube development|response to oxidative stress|negative regulation of cell death|response to drug|negative regulation of muscle tissue development|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|angiogenesis|gonad development|cell communication|positive regulation of organ growth|cell migration|signal transduction|outflow tract morphogenesis|mesendoderm development|regulation of developmental growth|cardiac septum development|neural precursor cell proliferation|response to hormone|otic vesicle formation|cell death|organ formation|bone development|pallium development|regulation of catalytic activity|cell projection organization|positive regulation of cell division|cell division|organ induction|cellular developmental process|genitalia development|midbrain-hindbrain boundary development|telencephalon development|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|diencephalon development|gland development|adenohypophysis development|endocardial cushion formation|organelle organization|cardiac chamber development|response to fibroblast growth factor|MAPK cascade|lung morphogenesis|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|mesendoderm migration|cell morphogenesis|neuron projection development|embryonic heart tube morphogenesis|regulation of gene expression|epithelium migration|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|regulation of organ formation|negative regulation of neuron death|positive regulation of cell cycle process|cell surface receptor signaling pathway|morphogenesis of an epithelium|growth factor receptor binding|patterning of blood vessels|mitotic cell cycle process|vasculature development|macromolecule modification|male sex differentiation|mesonephric tubule development|reproductive system development|cardiovascular system development|outflow tract septum morphogenesis|central nervous system development|urogenital system development|male genitalia development|ear development|mesoderm development|negative regulation of programmed cell death|regulation of RNA metabolic process|respiratory system development|embryonic heart tube development|cardiac muscle tissue development|heart morphogenesis|neuron death|branching morphogenesis of an epithelial tube|response to peptide|endoderm development|morphogenesis of a branching epithelium|gland morphogenesis|cell morphogenesis involved in differentiation|embryo development|cellular response to organonitrogen compound|metanephros development|positive regulation of gene expression|thyroid gland development|ameboidal-type cell migration|positive regulation of transferase activity|protein modification process|mitotic cell cycle|artery development|muscle tissue development|gastrulation|artery morphogenesis|pharyngeal system development|forebrain regionalization|regulation of organ morphogenesis|renal system development|negative regulation of striated muscle tissue development|pituitary gland development|inner ear morphogenesis|regionalization|salivary gland development|neural tube patterning|mesenchyme development|endocrine system development|corticotropin hormone secreting cell differentiation|morphogenesis of embryonic epithelium|signal transduction involved in regulation of gene expression|regulation of mitotic cell cycle|response to peptide hormone|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|response to growth factor|cell proliferation in forebrain|determination of heart left/right asymmetry|specification of organ identity|epithelial to mesenchymal transition involved in endocardial cushion formation|immune response-regulating signaling pathway|exocrine system development|regulation of neuron death|blood vessel remodeling|renal tubule development|forebrain generation of neurons|positive regulation of cellular protein metabolic process|kidney morphogenesis|programmed cell death|endocardial cushion development|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|kidney epithelium development|odontogenesis|regulation of organelle organization|limb morphogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|mitotic nuclear division|stem cell development|gene expression|positive chemotaxis|cell part morphogenesis|brain morphogenesis|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|thyroid-stimulating hormone-secreting cell differentiation|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|otic vesicle development|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|mesonephros development|limb development|muscle organ development|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of mitotic cell cycle|growth factor activity|circulatory system development|cellular response to hormone stimulus|regulation of programmed cell death|cell fate commitment|regulation of striated muscle tissue development|positive regulation of organelle organization|neuron development|neuron differentiation|axon guidance|Wnt signaling pathway|otic vesicle morphogenesis|neural plate development|central nervous system neuron differentiation|regulation of cardiac muscle tissue development|forebrain dorsal/ventral pattern formation|stem cell differentiation|cardiac epithelial to mesenchymal transition|embryo development ending in birth or egg hatching|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|regulation of odontogenesis|fibroblast growth factor receptor binding|ureteric bud development|epithelial cell differentiation|cellular response to peptide|regulation of MAPK cascade|regulation of neuron apoptotic process|rostrocaudal neural tube patterning|regulation of mitotic nuclear division|RNA biosynthetic process|regulation of RNA biosynthetic process|nephron tubule morphogenesis|mesenchymal cell development|cellular response to growth factor stimulus|cell migration involved in mesendoderm migration|mesonephric epithelium development|phosphorylation|branching involved in ureteric bud morphogenesis|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|ERK1 and ERK2 cascade|neural plate morphogenesis|axon development|heart looping|inositol lipid-mediated signaling|branching involved in salivary gland morphogenesis|ear morphogenesis|BMP signaling pathway|renal tubule morphogenesis|enzyme linked receptor protein signaling pathway|determination of bilateral symmetry|central nervous system neuron development|cellular response to peptide hormone stimulus|dorsal/ventral pattern formation|positive regulation of MAPK cascade|aorta morphogenesis|nephron tubule development|regulation of apoptotic process|anterior/posterior pattern specification|positive regulation of mitotic nuclear division|aorta development|negative regulation of apoptotic process|odontogenesis of dentin-containing tooth|response to insulin|mesenchymal cell differentiation|salivary gland morphogenesis|neuron apoptotic process|forebrain neuron differentiation|negative regulation of neuron apoptotic process|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|cell migration involved in gastrulation|neuron projection morphogenesis|hindlimb morphogenesis|epithelial to mesenchymal transition|embryonic limb morphogenesis|mesodermal cell migration|regulation of kinase activity|transcription, DNA-templated|endocardial cushion morphogenesis|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|negative regulation of cardiac muscle tissue development|neurotrophin TRK receptor signaling pathway|dorsal/ventral axon guidance|embryonic hindlimb morphogenesis|activation of MAPKK activity|transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|axonogenesis|type 2 fibroblast growth factor receptor binding|protein phosphorylation|motor neuron axon guidance|generation of neurons|determination of left/right symmetry|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|regulation of MAP kinase activity|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|cellular response to insulin stimulus|ureteric bud morphogenesis|Fc receptor signaling pathway|chordate embryonic development|forebrain neuron development|regulation of odontogenesis of dentin-containing tooth|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|type 1 fibroblast growth factor receptor binding|regulation of ERK1 and ERK2 cascade|positive regulation of phosphorylation|dopaminergic neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|glandular epithelial cell differentiation|Fc-epsilon receptor signaling pathway|neuroepithelial cell differentiation|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|neuroendocrine cell differentiation K04358 fibroblast growth factor[-] hsa05200|hsa04151|hsa04010|hsa04014|hsa04810|hsa04015|hsa05218 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Melanoma - Homo sapiens (human) 10:101770130-101780369 10 9 9 1 1 2 0.253253000172449 0.207166538979411 0.205502718866292 0.0226812722881533 0.0207888390921419 0.0474656250467011 0.221974086006051 0.0303119121423321 2.87243449288931 0.000118437255149233 0.000921748127013871 UP ENSG00000137628 DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 [Source:HGNC Symbol;Acc:HGNC:25942] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006950|GO:0043167|GO:0006955|GO:0023051|GO:0051707|GO:0009607|GO:0009605|GO:0016787|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0002757|GO:0045087|GO:0050688|GO:0003676|GO:0043168|GO:0006952|GO:0039528|GO:0001882|GO:0016817|GO:0098542|GO:0001817|GO:1900246|GO:0005737|GO:0002218|GO:0001816|GO:0009615|GO:0009966|GO:0001819|GO:0010646|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0051607|GO:0000166|GO:0009967|GO:1900245|GO:1902533|GO:0003677|GO:0039530|GO:0003723|GO:0035639|GO:0002758|GO:0001883|GO:0039529|GO:0016818|GO:0032549|GO:0098586|GO:0002764|GO:0035556|GO:0017076|GO:1902531|GO:0005856|GO:0045089|GO:0030522|GO:0045088|GO:0005524|GO:0030554|GO:0002221|GO:0003690|GO:0003725|GO:0045111|GO:0016462|GO:0003727|GO:0039535|GO:0017111|GO:0004386 immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|response to stress|ion binding|immune response|regulation of signaling|response to other organism|response to biotic stimulus|response to external stimulus|hydrolase activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|immune response-activating signal transduction|innate immune response|regulation of defense response to virus|nucleic acid binding|anion binding|defense response|cytoplasmic pattern recognition receptor signaling pathway in response to virus|nucleoside binding|hydrolase activity, acting on acid anhydrides|defense response to other organism|regulation of cytokine production|positive regulation of RIG-I signaling pathway|cytoplasm|activation of innate immune response|cytokine production|response to virus|regulation of signal transduction|positive regulation of cytokine production|regulation of cell communication|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|defense response to virus|nucleotide binding|positive regulation of signal transduction|positive regulation of MDA-5 signaling pathway|positive regulation of intracellular signal transduction|DNA binding|MDA-5 signaling pathway|RNA binding|purine ribonucleoside triphosphate binding|innate immune response-activating signal transduction|purine nucleoside binding|RIG-I signaling pathway|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|cellular response to virus|immune response-regulating signaling pathway|intracellular signal transduction|purine nucleotide binding|regulation of intracellular signal transduction|cytoskeleton|positive regulation of innate immune response|intracellular receptor signaling pathway|regulation of innate immune response|ATP binding|adenyl nucleotide binding|pattern recognition receptor signaling pathway|double-stranded DNA binding|double-stranded RNA binding|intermediate filament cytoskeleton|pyrophosphatase activity|single-stranded RNA binding|regulation of RIG-I signaling pathway|nucleoside-triphosphatase activity|helicase activity - - - - 4:168216293-168318807 68 121 220 296 342 440 0.64357520247818 1.04078056947087 1.87728628545736 2.5100469881593 2.65575060149255 3.90278229023506 1.18721401913547 3.0228599599623 -1.34833411164093 0.000118902676539425 0.000924888094165711 DOWN ENSG00000273003 ARL2-SNX15 ARL2-SNX15 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:49197] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0005622|GO:0043168|GO:0001882|GO:0007154|GO:0007165|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0035556|GO:0017076|GO:0032561|GO:0005525|GO:0007264|GO:0019001 signaling|cell|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|intracellular|anion binding|nucleoside binding|cell communication|signal transduction|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding - - - - 11:65014182-65040570 0 147 0 0 0 0 0 3.95077919326132 0 0 0 0 1.31692639775377 0 Inf 0.00011968398584022 0.000930723030287559 UP ENSG00000164002 EXO5 exonuclease 5 [Source:HGNC Symbol;Acc:HGNC:26115] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0042802|GO:0006281|GO:0006725|GO:1901360|GO:0051536|GO:0003676|GO:0034641|GO:0016788|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0046983|GO:0006139|GO:0005829|GO:0003677|GO:0051539|GO:0046872|GO:0036297|GO:0031981|GO:0004518|GO:0005654|GO:0006259|GO:0005634|GO:0042803|GO:0006974|GO:0004536|GO:0004527|GO:0090305|GO:0008408|GO:0008409|GO:0035312|GO:0008296|GO:0008297|GO:0008310|GO:0045145 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|identical protein binding|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|iron-sulfur cluster binding|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein dimerization activity|nucleobase-containing compound metabolic process|cytosol|DNA binding|4 iron, 4 sulfur cluster binding|metal ion binding|interstrand cross-link repair|nuclear lumen|nuclease activity|nucleoplasm|DNA metabolic process|nucleus|protein homodimerization activity|cellular response to DNA damage stimulus|deoxyribonuclease activity|exonuclease activity|nucleic acid phosphodiester bond hydrolysis|3'-5' exonuclease activity|5'-3' exonuclease activity|5'-3' exodeoxyribonuclease activity|3'-5'-exodeoxyribonuclease activity|single-stranded DNA exodeoxyribonuclease activity|single-stranded DNA 3'-5' exodeoxyribonuclease activity|single-stranded DNA 5'-3' exodeoxyribonuclease activity - - - - 1:40508741-40516556 304 323 171 147 123 109 2.00709324719765 1.93810238904212 1.01789681947416 0.869581556958232 0.66629611362534 0.674450528647237 1.65436415190464 0.73677606641027 1.16697872713376 0.000119784787877607 0.00093126433783804 UP ENSG00000213689 TREX1 three prime repair exonuclease 1 [Source:HGNC Symbol;Acc:HGNC:12269] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0044877|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0042802|GO:0006281|GO:0045087|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0016788|GO:0006952|GO:0046483|GO:0033554|GO:0001817|GO:0043231|GO:0043169|GO:0005737|GO:0001816|GO:0005635|GO:0032403|GO:0046983|GO:0001819|GO:0006139|GO:0005783|GO:0016021|GO:0044249|GO:0005829|GO:0003677|GO:0034645|GO:0032479|GO:0046872|GO:0032481|GO:0004518|GO:0032606|GO:0006298|GO:0006259|GO:0009059|GO:0005634|GO:0042803|GO:0006974|GO:0006260|GO:0004536|GO:0003697|GO:0032407|GO:0032405|GO:0004527|GO:0006310|GO:0090305|GO:0008408|GO:0008296|GO:0008853 immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|immune response|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|identical protein binding|DNA repair|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|defense response|heterocycle metabolic process|cellular response to stress|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|cytoplasm|cytokine production|nuclear envelope|protein complex binding|protein dimerization activity|positive regulation of cytokine production|nucleobase-containing compound metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|cytosol|DNA binding|cellular macromolecule biosynthetic process|regulation of type I interferon production|metal ion binding|positive regulation of type I interferon production|nuclease activity|type I interferon production|mismatch repair|DNA metabolic process|macromolecule biosynthetic process|nucleus|protein homodimerization activity|cellular response to DNA damage stimulus|DNA replication|deoxyribonuclease activity|single-stranded DNA binding|MutSalpha complex binding|MutLalpha complex binding|exonuclease activity|DNA recombination|nucleic acid phosphodiester bond hydrolysis|3'-5' exonuclease activity|3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity K10790 three prime repair exonuclease 1[3.1.11.2] hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human) 3:48465811-48467645 41 58 87 19 37 18 0.424073948420385 0.545205954172544 0.811306280571682 0.176078979444924 0.313994659897369 0.174482300087693 0.593528727721537 0.221518646476662 1.4218897165719 0.000120779400093953 0.000938263911112379 UP ENSG00000181826 RELL1 RELT-like 1 [Source:HGNC Symbol;Acc:HGNC:27379] GO:0005623|GO:0016020|GO:0043229|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0016021|GO:0005856|GO:0015630 cell|membrane|intracellular organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|integral component of membrane|cytoskeleton|microtubule cytoskeleton - - - - 4:37590800-37686376 96 148 236 71 82 73 3.4878034657259 4.88675948007308 7.73046727329325 2.31118656371605 2.4443504954824 2.48561585173448 5.36834340636408 2.41371763697764 1.15322004621534 0.000121083933051579 0.000940140373815825 UP ENSG00000214013 GANC glucosidase, alpha; neutral C [Source:HGNC Symbol;Acc:HGNC:4139] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0044237|GO:0030246|GO:0016787|GO:0044262|GO:0016798|GO:0005975|GO:0005984|GO:0009311|GO:0004553|GO:0000023|GO:0015926|GO:0032450|GO:0004558 cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|cellular metabolic process|carbohydrate binding|hydrolase activity|cellular carbohydrate metabolic process|hydrolase activity, acting on glycosyl bonds|carbohydrate metabolic process|disaccharide metabolic process|oligosaccharide metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|maltose metabolic process|glucosidase activity|maltose alpha-glucosidase activity|alpha-1,4-glucosidase activity K12317 neutral alpha-glucosidase C[3.2.1.20] hsa01100|hsa00500|hsa00052 Metabolic pathways - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Galactose metabolism - Homo sapiens (human) 15:42273233-42356935 56 62 45 135 130 134 0.288933501673518 0.290723029095719 0.209329848090554 0.624079253827023 0.55032565940376 0.647951724917626 0.26299545961993 0.607452212716136 -1.20773302579482 0.00012112480803237 0.000940213213468114 DOWN ENSG00000117114 ADGRL2 adhesion G protein-coupled receptor L2 [Source:HGNC Symbol;Acc:HGNC:18582] GO:0004871|GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0030246|GO:0031224|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0007166|GO:0016524|GO:0004930 signal transducer activity|signaling|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|carbohydrate binding|intrinsic component of membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|latrotoxin receptor activity|G-protein coupled receptor activity - - - - 1:81306160-81992436 158 268 376 524 553 711 0.601174387251964 0.926738580882719 1.2898685824098 1.78637387748785 1.72638007493415 2.53537132863167 0.939260516848161 2.01604176035122 -1.10192825333007 0.000121272723703678 0.000941116686625837 DOWN ENSG00000164120 HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) [Source:HGNC Symbol;Acc:HGNC:5154] GO:0032502|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0004872|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0038023|GO:0009653|GO:0043227|GO:0048037|GO:0071944|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048609|GO:0042802|GO:0048514|GO:0051726|GO:0007049|GO:0044255|GO:0016323|GO:0001568|GO:0006082|GO:0007275|GO:0043168|GO:0044281|GO:0031982|GO:0016614|GO:0045786|GO:0043231|GO:0004888|GO:0005737|GO:0071559|GO:0030728|GO:0046983|GO:0007154|GO:0007565|GO:0007276|GO:0006629|GO:0007165|GO:0070062|GO:0050662|GO:0000166|GO:0044249|GO:0010033|GO:0007567|GO:0055114|GO:0005829|GO:0007186|GO:0007166|GO:0001944|GO:0072358|GO:0006631|GO:0060840|GO:0071560|GO:0048844|GO:0070403|GO:0016616|GO:0031981|GO:0070848|GO:0005654|GO:0008610|GO:0071310|GO:0072359|GO:0007292|GO:0004930|GO:0005634|GO:0042803|GO:0051287|GO:0006690|GO:0019372|GO:0033559|GO:0001676|GO:0071363|GO:0070493|GO:0007179|GO:0016404|GO:0019369|GO:0007167|GO:0006633|GO:0019752|GO:0046456|GO:2001300|GO:0097070|GO:0006636|GO:0019371|GO:0032787|GO:0007178|GO:0006693|GO:0004955|GO:0001516|GO:0004957 developmental process|signal transducer activity|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|signaling receptor activity|anatomical structure morphogenesis|membrane-bounded organelle|cofactor binding|cell periphery|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|plasma membrane|anatomical structure development|multicellular organismal reproductive process|identical protein binding|blood vessel morphogenesis|regulation of cell cycle|cell cycle|cellular lipid metabolic process|basolateral plasma membrane|blood vessel development|organic acid metabolic process|multicellular organism development|anion binding|small molecule metabolic process|vesicle|oxidoreductase activity, acting on CH-OH group of donors|negative regulation of cell cycle|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|response to transforming growth factor beta|ovulation|protein dimerization activity|cell communication|female pregnancy|gamete generation|lipid metabolic process|signal transduction|extracellular exosome|coenzyme binding|nucleotide binding|cellular biosynthetic process|response to organic substance|parturition|oxidation-reduction process|cytosol|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|vasculature development|cardiovascular system development|fatty acid metabolic process|artery development|cellular response to transforming growth factor beta stimulus|artery morphogenesis|NAD+ binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|nuclear lumen|response to growth factor|nucleoplasm|lipid biosynthetic process|cellular response to organic substance|circulatory system development|female gamete generation|G-protein coupled receptor activity|nucleus|protein homodimerization activity|NAD binding|icosanoid metabolic process|lipoxygenase pathway|unsaturated fatty acid metabolic process|long-chain fatty acid metabolic process|cellular response to growth factor stimulus|thrombin receptor signaling pathway|transforming growth factor beta receptor signaling pathway|15-hydroxyprostaglandin dehydrogenase (NAD+) activity|arachidonic acid metabolic process|enzyme linked receptor protein signaling pathway|fatty acid biosynthetic process|carboxylic acid metabolic process|icosanoid biosynthetic process|lipoxin metabolic process|ductus arteriosus closure|unsaturated fatty acid biosynthetic process|cyclooxygenase pathway|monocarboxylic acid metabolic process|transmembrane receptor protein serine/threonine kinase signaling pathway|prostaglandin metabolic process|prostaglandin receptor activity|prostaglandin biosynthetic process|prostaglandin E receptor activity K00069 15-hydroxyprostaglandin dehydrogenase (NAD)[1.1.1.141] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 4:174490177-174523154 201 183 371 463 509 965 1.30094936696822 1.07645774591706 2.1649760436838 2.68499779711573 2.70303360463162 5.85358067518014 1.51412771885636 3.7472040256425 -1.30732762698463 0.000122346067685878 0.000949199455481863 DOWN ENSG00000170558 CDH2 cadherin 2, type 1, N-cadherin (neuronal) [Source:HGNC Symbol;Acc:HGNC:1759] GO:0040011|GO:0032502|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0019898|GO:0042995|GO:0030055|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0051050|GO:0044089|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0045177|GO:0048870|GO:0023051|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0031252|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0019222|GO:0048514|GO:0060341|GO:0042127|GO:0016337|GO:2000809|GO:0045595|GO:0051640|GO:0009888|GO:0008013|GO:0048468|GO:0016323|GO:0006810|GO:0051130|GO:0001568|GO:0031641|GO:0016324|GO:2000807|GO:0005938|GO:0098797|GO:0044853|GO:0007275|GO:0048513|GO:0044291|GO:0005924|GO:0030900|GO:0005912|GO:0031982|GO:0031325|GO:0051128|GO:0007420|GO:0022607|GO:0098609|GO:0051668|GO:0050803|GO:0061061|GO:0045597|GO:0043169|GO:0019899|GO:0005737|GO:0060322|GO:0021987|GO:0032880|GO:0006928|GO:0009887|GO:0032403|GO:0042592|GO:0009966|GO:0030027|GO:0045184|GO:0019897|GO:0045294|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0016477|GO:0007165|GO:0005913|GO:0009968|GO:0070062|GO:0050808|GO:0051649|GO:0061351|GO:0044091|GO:0021543|GO:0030030|GO:0048869|GO:0016021|GO:0021537|GO:0009967|GO:0019827|GO:0019538|GO:0023014|GO:0098857|GO:0031323|GO:0010256|GO:0045295|GO:0000165|GO:1902533|GO:0043113|GO:0032268|GO:0030111|GO:0000902|GO:0071709|GO:0031175|GO:0098742|GO:0031344|GO:0051149|GO:0045216|GO:0030178|GO:0090150|GO:0030864|GO:0007416|GO:0046872|GO:0044331|GO:0007166|GO:0001944|GO:0043412|GO:0050807|GO:0072358|GO:0007417|GO:1901631|GO:0042692|GO:0050998|GO:0097150|GO:0014704|GO:0000904|GO:0097090|GO:0051147|GO:0007009|GO:0036211|GO:0048872|GO:0034329|GO:0019902|GO:0097091|GO:0072657|GO:0051247|GO:0022604|GO:0005916|GO:0006461|GO:0034613|GO:0019900|GO:0032270|GO:0060429|GO:0006796|GO:0035556|GO:0001941|GO:0044267|GO:0051174|GO:0032990|GO:0048854|GO:0007399|GO:0016342|GO:0051648|GO:0051246|GO:0030154|GO:0048858|GO:0045121|GO:1903827|GO:1902531|GO:2000177|GO:0072359|GO:0005856|GO:0051960|GO:0005925|GO:0008366|GO:0048666|GO:0030182|GO:0015629|GO:0016055|GO:0010975|GO:0031401|GO:0007157|GO:0090090|GO:0010001|GO:0051259|GO:0030855|GO:0043408|GO:0010769|GO:0060828|GO:0034332|GO:0072659|GO:0090002|GO:0097104|GO:0016310|GO:0070445|GO:0005509|GO:0097118|GO:0061564|GO:0019903|GO:0007156|GO:0043410|GO:1901626|GO:0051146|GO:0042552|GO:1902897|GO:0051056|GO:0019901|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0030863|GO:0050767|GO:0016339|GO:0048812|GO:0097119|GO:1990778|GO:0007265|GO:0046578|GO:0007409|GO:0006468|GO:0048699|GO:0014013|GO:0051291|GO:0060070|GO:0042325|GO:0060019|GO:0001932|GO:0042063|GO:0001934|GO:0050770|GO:0045664|GO:0042327|GO:0060563|GO:0035023|GO:0007266 locomotion|developmental process|macromolecular complex|synapse|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|cell projection|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|positive regulation of transport|positive regulation of cellular component biogenesis|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|apical part of cell|cell motility|regulation of signaling|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|regulation of cell proliferation|single organismal cell-cell adhesion|positive regulation of synaptic vesicle clustering|regulation of cell differentiation|organelle localization|tissue development|beta-catenin binding|cell development|basolateral plasma membrane|transport|positive regulation of cellular component organization|blood vessel development|regulation of myelination|apical plasma membrane|regulation of synaptic vesicle clustering|cell cortex|plasma membrane protein complex|plasma membrane raft|multicellular organism development|animal organ development|cell-cell contact zone|cell-substrate adherens junction|forebrain development|adherens junction|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|brain development|cellular component assembly|cell-cell adhesion|localization within membrane|regulation of synapse structure or activity|muscle structure development|positive regulation of cell differentiation|cation binding|enzyme binding|cytoplasm|head development|cerebral cortex development|regulation of protein localization|movement of cell or subcellular component|organ morphogenesis|protein complex binding|homeostatic process|regulation of signal transduction|lamellipodium|establishment of protein localization|extrinsic component of plasma membrane|alpha-catenin binding|regulation of cell communication|protein localization|cell communication|membrane organization|cell migration|signal transduction|cell-cell adherens junction|negative regulation of signal transduction|extracellular exosome|synapse organization|establishment of localization in cell|neural precursor cell proliferation|membrane biogenesis|pallium development|cell projection organization|cellular developmental process|integral component of membrane|telencephalon development|positive regulation of signal transduction|stem cell population maintenance|protein metabolic process|signal transduction by protein phosphorylation|membrane microdomain|regulation of cellular metabolic process|endomembrane system organization|gamma-catenin binding|MAPK cascade|positive regulation of intracellular signal transduction|receptor clustering|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|membrane assembly|neuron projection development|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of cell projection organization|positive regulation of muscle cell differentiation|cell-cell junction organization|negative regulation of Wnt signaling pathway|establishment of protein localization to membrane|cortical actin cytoskeleton|synapse assembly|metal ion binding|cell-cell adhesion mediated by cadherin|cell surface receptor signaling pathway|vasculature development|macromolecule modification|regulation of synapse organization|cardiovascular system development|central nervous system development|positive regulation of presynaptic membrane organization|muscle cell differentiation|nitric-oxide synthase binding|neuronal stem cell population maintenance|intercalated disc|cell morphogenesis involved in differentiation|presynaptic membrane organization|regulation of muscle cell differentiation|plasma membrane organization|protein modification process|homeostasis of number of cells|cell junction assembly|phosphatase binding|synaptic vesicle clustering|protein localization to membrane|positive regulation of protein metabolic process|regulation of cell morphogenesis|fascia adherens|protein complex assembly|cellular protein localization|kinase binding|positive regulation of cellular protein metabolic process|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|postsynaptic membrane organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|brain morphogenesis|nervous system development|catenin complex|vesicle localization|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|membrane raft|regulation of cellular protein localization|regulation of intracellular signal transduction|regulation of neural precursor cell proliferation|circulatory system development|cytoskeleton|regulation of nervous system development|focal adhesion|axon ensheathment|neuron development|neuron differentiation|actin cytoskeleton|Wnt signaling pathway|regulation of neuron projection development|positive regulation of protein modification process|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|negative regulation of canonical Wnt signaling pathway|glial cell differentiation|protein oligomerization|epithelial cell differentiation|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|regulation of canonical Wnt signaling pathway|adherens junction organization|protein localization to plasma membrane|establishment of protein localization to plasma membrane|postsynaptic membrane assembly|phosphorylation|regulation of oligodendrocyte progenitor proliferation|calcium ion binding|neuroligin clustering involved in postsynaptic membrane assembly|axon development|protein phosphatase binding|homophilic cell adhesion via plasma membrane adhesion molecules|positive regulation of MAPK cascade|regulation of postsynaptic membrane organization|striated muscle cell differentiation|myelination|regulation of postsynaptic density protein 95 clustering|regulation of small GTPase mediated signal transduction|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|cortical cytoskeleton|regulation of neurogenesis|calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules|neuron projection morphogenesis|postsynaptic density protein 95 clustering|protein localization to cell periphery|Ras protein signal transduction|regulation of Ras protein signal transduction|axonogenesis|protein phosphorylation|generation of neurons|regulation of gliogenesis|protein heterooligomerization|canonical Wnt signaling pathway|regulation of phosphorylation|radial glial cell differentiation|regulation of protein phosphorylation|gliogenesis|positive regulation of protein phosphorylation|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|neuroepithelial cell differentiation|regulation of Rho protein signal transduction|Rho protein signal transduction K06736 cadherin 2, type 1, N-cadherin[-] hsa04514|hsa05412 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 18:27950966-28177446 30 51 81 157 183 104 0.331729427762052 0.512534442815447 0.807543432991942 1.55548557278518 1.66030624689241 1.07778079104072 0.550602434523147 1.43119087023944 -1.3781331953579 0.000122725830073119 0.000951651150909841 DOWN ENSG00000171444 MCC mutated in colorectal cancers [Source:HGNC Symbol;Acc:HGNC:6935] GO:0040011|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0042995|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0043167|GO:0048870|GO:0023051|GO:0043227|GO:0071944|GO:0023057|GO:0031252|GO:0005622|GO:0005515|GO:0005886|GO:0042127|GO:0010632|GO:0043231|GO:0043169|GO:0005737|GO:0006928|GO:0009966|GO:0030027|GO:0050673|GO:0045184|GO:0010646|GO:0008104|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0051271|GO:0008285|GO:2000145|GO:0010633|GO:2000146|GO:0030111|GO:0090132|GO:0030178|GO:0046872|GO:0007166|GO:0030334|GO:0001667|GO:0031981|GO:0005654|GO:0050678|GO:0050680|GO:0030336|GO:0005634|GO:0016055|GO:0090090|GO:0060828|GO:0005509|GO:0010631|GO:0060070 locomotion|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|cell projection|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|ion binding|cell motility|regulation of signaling|membrane-bounded organelle|cell periphery|negative regulation of signaling|cell leading edge|intracellular|protein binding|plasma membrane|regulation of cell proliferation|regulation of epithelial cell migration|intracellular membrane-bounded organelle|cation binding|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|lamellipodium|epithelial cell proliferation|establishment of protein localization|regulation of cell communication|protein localization|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|negative regulation of cellular component movement|negative regulation of cell proliferation|regulation of cell motility|negative regulation of epithelial cell migration|negative regulation of cell motility|regulation of Wnt signaling pathway|epithelium migration|negative regulation of Wnt signaling pathway|metal ion binding|cell surface receptor signaling pathway|regulation of cell migration|ameboidal-type cell migration|nuclear lumen|nucleoplasm|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|negative regulation of cell migration|nucleus|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of canonical Wnt signaling pathway|calcium ion binding|epithelial cell migration|canonical Wnt signaling pathway - - - - 5:113022099-113488830 25 24 51 94 98 76 0.119006626186236 0.103828751675482 0.218881596857455 0.400915732867182 0.38275607043145 0.339054596195168 0.147238991573058 0.3742421331646 -1.34581221615155 0.000123981069839678 0.000960885477412709 DOWN ENSG00000165188 RNF183 ring finger protein 183 [Source:HGNC Symbol;Acc:HGNC:28721] GO:0016020|GO:0005488|GO:0043167|GO:0031224|GO:0005515|GO:0043169|GO:0016021|GO:0046872|GO:0046914|GO:0008270 membrane|binding|ion binding|intrinsic component of membrane|protein binding|cation binding|integral component of membrane|metal ion binding|transition metal ion binding|zinc ion binding - - - - 9:113297093-113303376 21 17 21 4 4 9 0.188324570656036 0.138554077079368 0.169790278619944 0.0321403917884557 0.0294290907250942 0.0756392273263013 0.165556308785116 0.0457362366132837 1.8559124237597 0.000124243122647417 0.000962666541270694 UP ENSG00000183287 CCBE1 collagen and calcium binding EGF domains 1 [Source:HGNC Symbol;Acc:HGNC:29426] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0050794|GO:0040012|GO:0005578|GO:0071704|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0009893|GO:0005615|GO:0050793|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0001946|GO:0051272|GO:0001568|GO:0007275|GO:0010632|GO:0001945|GO:0031325|GO:2000147|GO:0090287|GO:0001817|GO:0043169|GO:0019899|GO:0001816|GO:0006928|GO:0032403|GO:0009966|GO:0001819|GO:0010646|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0010634|GO:0036303|GO:2000145|GO:0009967|GO:0005581|GO:0019538|GO:0010033|GO:0031323|GO:0032268|GO:0010574|GO:0002040|GO:0010468|GO:0090132|GO:0046872|GO:0007166|GO:0001944|GO:0048845|GO:0072358|GO:1901492|GO:0051604|GO:0005518|GO:0010628|GO:0030334|GO:0001667|GO:0010575|GO:0045766|GO:0002020|GO:0045765|GO:0051247|GO:0070848|GO:0006508|GO:0032270|GO:1901342|GO:0044267|GO:0010467|GO:0060841|GO:0071310|GO:0010594|GO:0051246|GO:0030335|GO:0072359|GO:1900746|GO:1900748|GO:0010595|GO:0010573|GO:1903319|GO:0016485|GO:0030162|GO:0045862|GO:0071363|GO:0005509|GO:0007167|GO:0010631|GO:0010954|GO:0035924|GO:0070613|GO:0043542|GO:0007169|GO:0038084 locomotion|developmental process|extracellular matrix|macromolecular complex|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|regulation of locomotion|proteinaceous extracellular matrix|organic substance metabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|positive regulation of metabolic process|extracellular space|regulation of developmental process|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|lymphangiogenesis|positive regulation of cellular component movement|blood vessel development|multicellular organism development|regulation of epithelial cell migration|lymph vessel development|positive regulation of cellular metabolic process|positive regulation of cell motility|regulation of cellular response to growth factor stimulus|regulation of cytokine production|cation binding|enzyme binding|cytokine production|movement of cell or subcellular component|protein complex binding|regulation of signal transduction|positive regulation of cytokine production|regulation of cell communication|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|positive regulation of epithelial cell migration|lymph vessel morphogenesis|regulation of cell motility|positive regulation of signal transduction|collagen trimer|protein metabolic process|response to organic substance|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of vascular endothelial growth factor production|sprouting angiogenesis|regulation of gene expression|epithelium migration|metal ion binding|cell surface receptor signaling pathway|vasculature development|venous blood vessel morphogenesis|cardiovascular system development|positive regulation of lymphangiogenesis|protein maturation|collagen binding|positive regulation of gene expression|regulation of cell migration|ameboidal-type cell migration|positive regulation of vascular endothelial growth factor production|positive regulation of angiogenesis|protease binding|regulation of angiogenesis|positive regulation of protein metabolic process|response to growth factor|proteolysis|positive regulation of cellular protein metabolic process|regulation of vasculature development|cellular protein metabolic process|gene expression|venous blood vessel development|cellular response to organic substance|regulation of endothelial cell migration|regulation of protein metabolic process|positive regulation of cell migration|circulatory system development|regulation of vascular endothelial growth factor signaling pathway|positive regulation of vascular endothelial growth factor signaling pathway|positive regulation of endothelial cell migration|vascular endothelial growth factor production|positive regulation of protein maturation|protein processing|regulation of proteolysis|positive regulation of proteolysis|cellular response to growth factor stimulus|calcium ion binding|enzyme linked receptor protein signaling pathway|epithelial cell migration|positive regulation of protein processing|cellular response to vascular endothelial growth factor stimulus|regulation of protein processing|endothelial cell migration|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor signaling pathway - - - - 18:59430940-59697380 82 111 222 301 332 392 0.745076070076445 0.916624400184275 1.8186675726587 2.45047699337582 2.47510343032852 3.33811894137238 1.16012268097314 2.75456645502557 -1.247547892989 0.000124315009996501 0.000962973614020642 DOWN ENSG00000128159 TUBGCP6 tubulin gamma complex associated protein 6 [Source:HGNC Symbol;Acc:HGNC:18127] GO:0032991|GO:0000003|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0005488|GO:1903561|GO:0005200|GO:0044877|GO:0050794|GO:0043229|GO:0044089|GO:0044702|GO:0051321|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0000930|GO:0022402|GO:0051130|GO:0005874|GO:0031982|GO:0051128|GO:0022607|GO:0005737|GO:0032886|GO:0032403|GO:0007126|GO:0070062|GO:0008092|GO:0000923|GO:0007017|GO:0031334|GO:0043254|GO:0006996|GO:0031023|GO:0015631|GO:0005829|GO:0005813|GO:1903047|GO:0007010|GO:0070507|GO:0005815|GO:0044770|GO:0007098|GO:0051415|GO:0008017|GO:0000278|GO:0007051|GO:0006461|GO:0070925|GO:0032273|GO:0033043|GO:0007067|GO:0051298|GO:0000226|GO:0005856|GO:0000922|GO:0005819|GO:0010638|GO:0008274|GO:0051225|GO:0034622|GO:0031113|GO:0000086|GO:0031122|GO:0044772|GO:0043623|GO:0031116|GO:0007052|GO:0031110|GO:0051493|GO:0015630|GO:0007020|GO:0031109|GO:0051297|GO:0043015|GO:0051495|GO:0090307|GO:0051011|GO:0051258|GO:0010968|GO:0090063|GO:0046785 macromolecular complex|reproduction|structural molecule activity|cell|membrane|cellular process|extracellular region|reproductive process|binding|extracellular vesicle|structural constituent of cytoskeleton|macromolecular complex binding|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|single organism reproductive process|meiotic cell cycle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|gamma-tubulin complex|cell cycle process|positive regulation of cellular component organization|microtubule|vesicle|regulation of cellular component organization|cellular component assembly|cytoplasm|regulation of microtubule-based process|protein complex binding|meiotic nuclear division|extracellular exosome|cytoskeletal protein binding|equatorial microtubule organizing center|microtubule-based process|positive regulation of protein complex assembly|regulation of protein complex assembly|organelle organization|microtubule organizing center organization|tubulin binding|cytosol|centrosome|mitotic cell cycle process|cytoskeleton organization|regulation of microtubule cytoskeleton organization|microtubule organizing center|cell cycle phase transition|centrosome cycle|interphase microtubule nucleation by interphase microtubule organizing center|microtubule binding|mitotic cell cycle|spindle organization|protein complex assembly|organelle assembly|positive regulation of protein polymerization|regulation of organelle organization|mitotic nuclear division|centrosome duplication|microtubule cytoskeleton organization|cytoskeleton|spindle pole|spindle|positive regulation of organelle organization|gamma-tubulin ring complex|spindle assembly|cellular macromolecular complex assembly|regulation of microtubule polymerization|G2/M transition of mitotic cell cycle|cytoplasmic microtubule organization|mitotic cell cycle phase transition|cellular protein complex assembly|positive regulation of microtubule polymerization|mitotic spindle organization|regulation of microtubule polymerization or depolymerization|regulation of cytoskeleton organization|microtubule cytoskeleton|microtubule nucleation|microtubule polymerization or depolymerization|centrosome organization|gamma-tubulin binding|positive regulation of cytoskeleton organization|mitotic spindle assembly|microtubule minus-end binding|protein polymerization|regulation of microtubule nucleation|positive regulation of microtubule nucleation|microtubule polymerization - - - - 22:50217689-50244992 230 269 462 553 713 766 1.02336447028028 1.08776668033259 1.8533605353246 2.2045807840393 2.60292099720221 3.19418967586289 1.32149722864582 2.66723048570147 -1.01316909967298 0.000124569112633425 0.000964691644243388 DOWN ENSG00000198121 LPAR1 lysophosphatidic acid receptor 1 [Source:HGNC Symbol;Acc:HGNC:3166] GO:0040011|GO:0032502|GO:0004871|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0042995|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0044089|GO:0048520|GO:0071704|GO:0043167|GO:0009628|GO:0009986|GO:0044237|GO:0050795|GO:0038023|GO:0048870|GO:0023051|GO:0044297|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0051272|GO:0043198|GO:0008360|GO:0006935|GO:0045595|GO:0006725|GO:0005504|GO:0048468|GO:0043025|GO:0051130|GO:1901360|GO:0010941|GO:0007275|GO:0045596|GO:0048513|GO:0016358|GO:0034641|GO:0043168|GO:0044281|GO:0030902|GO:0030900|GO:0005543|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0007420|GO:0022607|GO:0010942|GO:0005887|GO:0045597|GO:0043231|GO:0004888|GO:0005737|GO:0035727|GO:0032970|GO:0001965|GO:0060322|GO:0050920|GO:0006928|GO:0042592|GO:0043177|GO:0022038|GO:0043005|GO:0009966|GO:0009890|GO:0043197|GO:0019725|GO:0036477|GO:0019904|GO:0032231|GO:0010646|GO:0006139|GO:0031226|GO:0043085|GO:0055086|GO:0007154|GO:0060996|GO:0022037|GO:0051270|GO:0016477|GO:0007165|GO:0032233|GO:0021675|GO:0008219|GO:0050790|GO:0030030|GO:0021549|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0021537|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0005768|GO:0050921|GO:0006996|GO:0051017|GO:0050768|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0060998|GO:0005829|GO:0031175|GO:0007186|GO:0031344|GO:0032956|GO:0033993|GO:0043412|GO:0007010|GO:0044309|GO:0050773|GO:0007417|GO:0021782|GO:0031410|GO:0051345|GO:0019693|GO:0010720|GO:0048878|GO:0046683|GO:0010721|GO:0030165|GO:0031346|GO:0030334|GO:0016023|GO:0051347|GO:0036211|GO:0055082|GO:0031345|GO:0060999|GO:0060326|GO:0050769|GO:0030031|GO:0030425|GO:0051247|GO:0031988|GO:0022604|GO:0071673|GO:0030036|GO:0071453|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:1901137|GO:0033043|GO:0044267|GO:0031406|GO:0051174|GO:0007399|GO:0071310|GO:0036041|GO:0051246|GO:0030154|GO:1900006|GO:0030335|GO:0051496|GO:0043068|GO:1902531|GO:0004930|GO:0051492|GO:0043067|GO:0051960|GO:0008366|GO:0021545|GO:0010638|GO:0048666|GO:0030182|GO:1904566|GO:0010975|GO:0007200|GO:0031401|GO:0007187|GO:0043122|GO:0010001|GO:0043065|GO:0030139|GO:0009259|GO:0043408|GO:0009117|GO:0046390|GO:0014909|GO:0021554|GO:0045980|GO:0045125|GO:0014003|GO:0016310|GO:0014910|GO:0071670|GO:0051493|GO:0032060|GO:0014911|GO:0043123|GO:0007249|GO:0043410|GO:0006163|GO:0048709|GO:0042981|GO:0050801|GO:0051057|GO:0042552|GO:0045665|GO:0031032|GO:0051056|GO:0022008|GO:0030038|GO:0007264|GO:0006464|GO:0007015|GO:0050767|GO:0051495|GO:0009165|GO:0071396|GO:0010976|GO:0010977|GO:0060193|GO:0043549|GO:0006915|GO:0006873|GO:0033674|GO:0045666|GO:0070915|GO:0007265|GO:0046578|GO:0006164|GO:0045859|GO:0045860|GO:0043406|GO:0007188|GO:0010517|GO:0006468|GO:0048699|GO:0046579|GO:0043405|GO:0051482|GO:0042325|GO:0001932|GO:0043149|GO:0042063|GO:0009187|GO:0001934|GO:0010518|GO:0061572|GO:0045664|GO:0030003|GO:0042327|GO:0030802|GO:0009190|GO:0007193|GO:0030818|GO:0010863|GO:0046058|GO:0000187|GO:0055065|GO:0009152|GO:0071902|GO:0030817|GO:0052652|GO:0006875|GO:0035023|GO:0030814|GO:0071900|GO:0007266|GO:0030815|GO:0032147|GO:0035025|GO:0006171|GO:0006874|GO:0007202|GO:0055074|GO:0051480|GO:0007204 locomotion|developmental process|signal transducer activity|synapse|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|cell projection|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of cellular component biogenesis|positive regulation of behavior|organic substance metabolic process|ion binding|response to abiotic stimulus|cell surface|cellular metabolic process|regulation of behavior|signaling receptor activity|cell motility|regulation of signaling|cell body|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|positive regulation of cellular component movement|dendritic shaft|regulation of cell shape|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|fatty acid binding|cell development|neuronal cell body|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|animal organ development|dendrite development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|hindbrain development|forebrain development|phospholipid binding|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|brain development|cellular component assembly|positive regulation of cell death|integral component of plasma membrane|positive regulation of cell differentiation|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|lysophosphatidic acid binding|regulation of actin filament-based process|G-protein alpha-subunit binding|head development|regulation of chemotaxis|movement of cell or subcellular component|homeostatic process|organic acid binding|corpus callosum development|neuron projection|regulation of signal transduction|negative regulation of biosynthetic process|dendritic spine|cellular homeostasis|somatodendritic compartment|protein domain specific binding|regulation of actin filament bundle assembly|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|cell communication|dendritic spine development|metencephalon development|regulation of cellular component movement|cell migration|signal transduction|positive regulation of actin filament bundle assembly|nerve development|cell death|regulation of catalytic activity|cell projection organization|cerebellum development|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|telencephalon development|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|endosome|positive regulation of chemotaxis|organelle organization|actin filament bundle assembly|negative regulation of neurogenesis|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|regulation of cell projection organization|regulation of actin cytoskeleton organization|response to lipid|macromolecule modification|cytoskeleton organization|neuron spine|regulation of dendrite development|central nervous system development|glial cell development|cytoplasmic vesicle|positive regulation of hydrolase activity|ribose phosphate metabolic process|positive regulation of cell development|chemical homeostasis|response to organophosphorus|negative regulation of cell development|PDZ domain binding|positive regulation of cell projection organization|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|protein modification process|cellular chemical homeostasis|negative regulation of cell projection organization|positive regulation of dendritic spine development|cell chemotaxis|positive regulation of neurogenesis|cell projection assembly|dendrite|positive regulation of protein metabolic process|membrane-bounded vesicle|regulation of cell morphogenesis|positive regulation of smooth muscle cell chemotaxis|actin cytoskeleton organization|cellular response to oxygen levels|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|carboxylic acid binding|regulation of phosphorus metabolic process|nervous system development|cellular response to organic substance|long-chain fatty acid binding|regulation of protein metabolic process|cell differentiation|positive regulation of dendrite development|positive regulation of cell migration|positive regulation of stress fiber assembly|positive regulation of programmed cell death|regulation of intracellular signal transduction|G-protein coupled receptor activity|regulation of stress fiber assembly|regulation of programmed cell death|regulation of nervous system development|axon ensheathment|cranial nerve development|positive regulation of organelle organization|neuron development|neuron differentiation|cellular response to 1-oleoyl-sn-glycerol 3-phosphate|regulation of neuron projection development|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of protein modification process|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|regulation of I-kappaB kinase/NF-kappaB signaling|glial cell differentiation|positive regulation of apoptotic process|endocytic vesicle|ribonucleotide metabolic process|regulation of MAPK cascade|nucleotide metabolic process|ribose phosphate biosynthetic process|smooth muscle cell migration|optic nerve development|negative regulation of nucleotide metabolic process|bioactive lipid receptor activity|oligodendrocyte development|phosphorylation|regulation of smooth muscle cell migration|smooth muscle cell chemotaxis|regulation of cytoskeleton organization|bleb assembly|positive regulation of smooth muscle cell migration|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|purine nucleotide metabolic process|oligodendrocyte differentiation|regulation of apoptotic process|ion homeostasis|positive regulation of small GTPase mediated signal transduction|myelination|negative regulation of neuron differentiation|actomyosin structure organization|regulation of small GTPase mediated signal transduction|neurogenesis|contractile actin filament bundle assembly|small GTPase mediated signal transduction|cellular protein modification process|actin filament organization|regulation of neurogenesis|positive regulation of cytoskeleton organization|nucleotide biosynthetic process|cellular response to lipid|positive regulation of neuron projection development|negative regulation of neuron projection development|positive regulation of lipase activity|regulation of kinase activity|apoptotic process|cellular ion homeostasis|positive regulation of kinase activity|positive regulation of neuron differentiation|lysophosphatidic acid receptor activity|Ras protein signal transduction|regulation of Ras protein signal transduction|purine nucleotide biosynthetic process|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|regulation of phospholipase activity|protein phosphorylation|generation of neurons|positive regulation of Ras protein signal transduction|regulation of MAP kinase activity|positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway|regulation of phosphorylation|regulation of protein phosphorylation|stress fiber assembly|gliogenesis|cyclic nucleotide metabolic process|positive regulation of protein phosphorylation|positive regulation of phospholipase activity|actin filament bundle organization|regulation of neuron differentiation|cellular cation homeostasis|positive regulation of phosphorylation|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of cAMP biosynthetic process|positive regulation of phospholipase C activity|cAMP metabolic process|activation of MAPK activity|metal ion homeostasis|purine ribonucleotide biosynthetic process|positive regulation of protein serine/threonine kinase activity|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|cellular metal ion homeostasis|regulation of Rho protein signal transduction|regulation of cAMP metabolic process|regulation of protein serine/threonine kinase activity|Rho protein signal transduction|negative regulation of cAMP metabolic process|activation of protein kinase activity|positive regulation of Rho protein signal transduction|cAMP biosynthetic process|cellular calcium ion homeostasis|activation of phospholipase C activity|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04289 lysophosphatidic acid receptor 1[-] hsa05200|hsa04151|hsa04080|hsa04015|hsa04072|hsa04540 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Neuroactive ligand-receptor interaction - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Gap junction - Homo sapiens (human) 9:110873263-111038458 72 93 63 158 269 164 0.522046082007326 0.6128279538757 0.411840626615656 1.02643031168713 1.60027328246357 1.1144118552894 0.515571554166227 1.2470384831467 -1.27426141426782 0.000124832525340954 0.000966480863985694 DOWN ENSG00000102904 TSNAXIP1 translin-associated factor X interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:18586] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0044702|GO:0019953|GO:0032504|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0007275|GO:0005737|GO:0007276|GO:0048869|GO:0048232|GO:0048471|GO:0030154|GO:0007283 developmental process|reproduction|cell|cellular process|reproductive process|binding|single organism reproductive process|sexual reproduction|multicellular organism reproduction|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|multicellular organism development|cytoplasm|gamete generation|cellular developmental process|male gamete generation|perinuclear region of cytoplasm|cell differentiation|spermatogenesis - - - - 16:67806765-67832148 9 12 18 39 40 40 0.0690119454751148 0.0836257588020416 0.124444979505782 0.267941146270839 0.251657565359592 0.287456086597369 0.0923608945943128 0.269018266075933 -1.5423500816548 0.000125407737027517 0.000970001046805639 DOWN ENSG00000100226 GTPBP1 GTP binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4669] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0043234|GO:0019222|GO:0006725|GO:0000178|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0001882|GO:0031325|GO:0046483|GO:0016817|GO:0005737|GO:0006139|GO:0007154|GO:0007165|GO:0000166|GO:0044249|GO:0019538|GO:0031323|GO:0005829|GO:0034645|GO:0006518|GO:0003723|GO:0035639|GO:0051252|GO:0001883|GO:0044265|GO:0016818|GO:0000177|GO:0032549|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0019439|GO:0009059|GO:0016070|GO:0006401|GO:0032561|GO:0043043|GO:0006412|GO:0016071|GO:0044822|GO:0005525|GO:0008135|GO:0061014|GO:0019001|GO:0016462|GO:0006414|GO:0003746|GO:0006402|GO:0017111|GO:0003924 macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|exosome (RNase complex)|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|cytoplasm|nucleobase-containing compound metabolic process|cell communication|signal transduction|nucleotide binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|cytosol|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|purine ribonucleoside triphosphate binding|regulation of RNA metabolic process|purine nucleoside binding|cellular macromolecule catabolic process|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cytoplasmic exosome (RNase complex)|ribonucleoside binding|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|aromatic compound catabolic process|macromolecule biosynthetic process|RNA metabolic process|RNA catabolic process|guanyl ribonucleotide binding|peptide biosynthetic process|translation|mRNA metabolic process|poly(A) RNA binding|GTP binding|translation factor activity, RNA binding|positive regulation of mRNA catabolic process|guanyl nucleotide binding|pyrophosphatase activity|translational elongation|translation elongation factor activity|mRNA catabolic process|nucleoside-triphosphatase activity|GTPase activity - - - - 22:38705723-38738299 560 714 766 1635 972 1758 3.1107782752899 3.60461713002759 3.83640015790494 8.13760009185003 4.43011656720493 9.152270131782 3.51726518774081 7.23999559694565 -1.04153470741828 0.000125538756725392 0.000970530616611828 DOWN ENSG00000253930 RP11-1149O23.2 - - - - - - - 8:23189279-23190675 43 72 41 24 22 17 4.77505315407118 7.26638265257928 4.1048665766635 2.38787495188695 2.00450222090323 1.7692287361413 5.38210079443799 2.05386863631049 1.38982549854952 0.000125674487490257 0.000971236383519064 UP ENSG00000273796 LL21NC02-21A1.1 - - - - - - - 21:45403809-45404369 0 0 2 6 9 9 0 0 0.227372734391136 0.677870081356521 0.931081217225381 1.06353337816375 0.075790911463712 0.890828225581884 -3.55505050835039 0.000127611732833852 0.000985187657621361 DOWN ENSG00000180354 MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus) [Source:HGNC Symbol;Acc:HGNC:25457] GO:0032502|GO:0048856|GO:0007275 developmental process|anatomical structure development|multicellular organism development - - - - 7:30134810-30162762 90 98 134 159 416 287 0.496706382861079 0.49154682092134 0.666775276780713 0.78623725632523 1.88374026321538 1.48446645025503 0.551676160187711 1.38481465659855 -1.32779935594345 0.000128520947460834 0.000991694072239789 DOWN ENSG00000267254 ZNF790-AS1 ZNF790 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:27617] - - - - - - 19:36797518-36828115 32 15 25 5 11 5 0.876008721454751 0.373196577338975 0.617034800983347 0.122628561891699 0.247060718530654 0.128289180974842 0.622080033259024 0.165992820465732 1.90597935782442 0.000129523465238411 0.000998406731013471 UP ENSG00000114737 CISH cytokine inducible SH2-containing protein [Source:HGNC Symbol;Acc:HGNC:1984] GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0016049|GO:0071704|GO:0044237|GO:0023051|GO:0016043|GO:0071944|GO:0040008|GO:0023057|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0051726|GO:0007049|GO:0004857|GO:0051128|GO:1900076|GO:0010243|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0009725|GO:0050790|GO:0019207|GO:0043086|GO:0019538|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0032268|GO:0005829|GO:0007186|GO:0019210|GO:0007166|GO:0043412|GO:0034097|GO:0019887|GO:1901652|GO:0071417|GO:0036211|GO:0032269|GO:0043434|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:1902532|GO:0046627|GO:0051246|GO:0046626|GO:1902531|GO:0032870|GO:0019221|GO:1901653|GO:0016310|GO:0060416|GO:1904030|GO:0007167|GO:0071375|GO:0004860|GO:0071345|GO:0033673|GO:0032868|GO:0006464|GO:0007205|GO:0043549|GO:0007259|GO:0045859|GO:0006469|GO:0006468|GO:0046425|GO:0042325|GO:0071378|GO:0046426|GO:0001932|GO:0032869|GO:0042326|GO:0001933|GO:0007169|GO:0032446|GO:0060397|GO:0060396|GO:0008286|GO:0016567 growth|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|cell growth|organic substance metabolic process|cellular metabolic process|regulation of signaling|cellular component organization|cell periphery|regulation of growth|negative regulation of signaling|enzyme regulator activity|intracellular|protein binding|plasma membrane|regulation of metabolic process|regulation of cell cycle|cell cycle|enzyme inhibitor activity|regulation of cellular component organization|regulation of cellular response to insulin stimulus|response to organonitrogen compound|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|response to hormone|regulation of catalytic activity|kinase regulator activity|negative regulation of catalytic activity|protein metabolic process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|kinase inhibitor activity|cell surface receptor signaling pathway|macromolecule modification|response to cytokine|protein kinase regulator activity|response to peptide|cellular response to organonitrogen compound|protein modification process|negative regulation of cellular protein metabolic process|response to peptide hormone|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|negative regulation of insulin receptor signaling pathway|regulation of protein metabolic process|regulation of insulin receptor signaling pathway|regulation of intracellular signal transduction|cellular response to hormone stimulus|cytokine-mediated signaling pathway|cellular response to peptide|phosphorylation|response to growth hormone|negative regulation of cyclin-dependent protein kinase activity|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|protein kinase inhibitor activity|cellular response to cytokine stimulus|negative regulation of kinase activity|response to insulin|cellular protein modification process|protein kinase C-activating G-protein coupled receptor signaling pathway|regulation of kinase activity|JAK-STAT cascade|regulation of protein kinase activity|negative regulation of protein kinase activity|protein phosphorylation|regulation of JAK-STAT cascade|regulation of phosphorylation|cellular response to growth hormone stimulus|negative regulation of JAK-STAT cascade|regulation of protein phosphorylation|cellular response to insulin stimulus|negative regulation of phosphorylation|negative regulation of protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|JAK-STAT cascade involved in growth hormone signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|protein ubiquitination K04701 cytokine inducible SH2-containing protein[-] hsa04630|hsa04917 Jak-STAT signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human) 3:50606490-50611831 99 105 149 53 71 61 0.77543139255214 0.747447363853412 1.05223077491665 0.371950947939782 0.456282515410485 0.447782536296492 0.858369843774067 0.42533866654892 1.01298737928579 0.000129887145819321 0.00100042591622549 UP ENSG00000177425 PAWR PRKC, apoptosis, WT1, regulator [Source:HGNC Symbol;Acc:HGNC:8614] GO:0040011|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0042995|GO:0002683|GO:0009892|GO:0045760|GO:0048523|GO:0051606|GO:0008283|GO:0098900|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0050900|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0048870|GO:0023051|GO:0000989|GO:0044297|GO:0040017|GO:0016043|GO:0051707|GO:0007155|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0019222|GO:1904457|GO:0051272|GO:0002757|GO:0042127|GO:0051969|GO:0016337|GO:0042391|GO:0003712|GO:0006725|GO:0051971|GO:0070661|GO:0002685|GO:0045123|GO:0043025|GO:0006810|GO:0009612|GO:1901360|GO:0005884|GO:0010941|GO:0009991|GO:0050877|GO:0070489|GO:0034641|GO:0030155|GO:0031325|GO:0046483|GO:0042094|GO:2000147|GO:0022607|GO:0010942|GO:0098609|GO:0009582|GO:0043231|GO:0019899|GO:0005737|GO:0003012|GO:0001816|GO:0031668|GO:0009611|GO:0006928|GO:0002687|GO:0001775|GO:0043005|GO:0009966|GO:0098908|GO:0009890|GO:0036477|GO:0019904|GO:0010646|GO:0006139|GO:0043085|GO:0009617|GO:0007162|GO:0050776|GO:0046649|GO:0050906|GO:0050865|GO:0007154|GO:0055085|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0009968|GO:0045785|GO:0007586|GO:0008092|GO:0009725|GO:0008219|GO:0002695|GO:0008285|GO:0050790|GO:0030029|GO:2000145|GO:0010035|GO:0044249|GO:0009266|GO:0019538|GO:0010033|GO:0060456|GO:0031324|GO:0031323|GO:0034763|GO:0043271|GO:0006996|GO:0007584|GO:0098657|GO:0051017|GO:0042107|GO:0051249|GO:0032268|GO:0042113|GO:0044058|GO:0010468|GO:0006936|GO:0034645|GO:0034698|GO:0032943|GO:0003714|GO:0042089|GO:0007166|GO:0002691|GO:0033993|GO:0030424|GO:0043412|GO:0007010|GO:0034097|GO:0032623|GO:0051345|GO:1903020|GO:0010629|GO:0042984|GO:0002237|GO:0042986|GO:0051252|GO:0034109|GO:1901216|GO:0003779|GO:0070997|GO:0051604|GO:0030275|GO:0090257|GO:0050901|GO:0001508|GO:0010038|GO:0030334|GO:0051926|GO:0009100|GO:0036211|GO:0031670|GO:0006811|GO:0033273|GO:0051250|GO:0019902|GO:0002429|GO:0050860|GO:0022408|GO:0007600|GO:0022407|GO:1901082|GO:0016048|GO:1902622|GO:0019226|GO:0031644|GO:0007159|GO:0033197|GO:0034766|GO:0051247|GO:0006508|GO:0034765|GO:0070664|GO:0002764|GO:0050961|GO:1901214|GO:0030036|GO:0043269|GO:0045987|GO:0019900|GO:0032270|GO:0050982|GO:0042110|GO:0012501|GO:0014070|GO:0006796|GO:0090075|GO:0042982|GO:0050974|GO:1901137|GO:0002693|GO:0044267|GO:0051174|GO:0060450|GO:0010467|GO:0072672|GO:0071310|GO:0031328|GO:0051246|GO:0010039|GO:0046651|GO:0009059|GO:0022409|GO:0030335|GO:0043068|GO:0031669|GO:0016070|GO:0031667|GO:0032870|GO:0005856|GO:0010557|GO:0032496|GO:0005634|GO:0043067|GO:0048545|GO:0097305|GO:0097190|GO:0034220|GO:0071371|GO:1903038|GO:0015629|GO:0042098|GO:0009101|GO:0016311|GO:0010560|GO:0050951|GO:0032354|GO:0031401|GO:0050863|GO:0090281|GO:0070555|GO:1990266|GO:0050856|GO:0006939|GO:0043065|GO:0019233|GO:0050954|GO:0006937|GO:0050869|GO:0016485|GO:0045892|GO:0043523|GO:0010922|GO:0050966|GO:0032774|GO:1903238|GO:0050868|GO:0030162|GO:0006812|GO:2001141|GO:0071306|GO:0045862|GO:0043525|GO:0043627|GO:0002768|GO:1901077|GO:1902679|GO:0052547|GO:0071383|GO:0071407|GO:0070486|GO:0019903|GO:0050864|GO:2000391|GO:0071295|GO:0032355|GO:0042981|GO:0071345|GO:0010559|GO:0050965|GO:0043134|GO:0043522|GO:0010040|GO:0051402|GO:0042100|GO:0034111|GO:0032945|GO:0019901|GO:0044557|GO:0006464|GO:0050851|GO:0007015|GO:0010952|GO:0071396|GO:0050672|GO:0006351|GO:0006915|GO:0006355|GO:0090279|GO:0019228|GO:0010921|GO:1903039|GO:0006470|GO:0035304|GO:0006366|GO:1903507|GO:0010950|GO:0006940|GO:0071347|GO:0006357|GO:0035307|GO:1903506|GO:0071372|GO:0043666|GO:0032516|GO:0008157|GO:0005080|GO:0071392|GO:0031638|GO:0030889|GO:0030001|GO:0030888|GO:0042130|GO:0071391|GO:0035306|GO:0051924|GO:0050852|GO:0042129|GO:0000122|GO:0061572|GO:0071593|GO:0035303|GO:0052548|GO:2001056|GO:2000116|GO:0097202|GO:1990035|GO:0006816|GO:0070509 locomotion|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|cell projection|negative regulation of immune system process|negative regulation of metabolic process|positive regulation of action potential|negative regulation of cellular process|detection of stimulus|cell proliferation|regulation of action potential|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|leukocyte migration|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|cell body|positive regulation of locomotion|cellular component organization|response to other organism|cell adhesion|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|regulation of metabolic process|positive regulation of neuronal action potential|positive regulation of cellular component movement|immune response-activating signal transduction|regulation of cell proliferation|regulation of transmission of nerve impulse|single organismal cell-cell adhesion|regulation of membrane potential|transcription cofactor activity|cellular aromatic compound metabolic process|positive regulation of transmission of nerve impulse|leukocyte proliferation|regulation of leukocyte migration|cellular extravasation|neuronal cell body|transport|response to mechanical stimulus|organic cyclic compound metabolic process|actin filament|regulation of cell death|response to extracellular stimulus|neurological system process|T cell aggregation|cellular nitrogen compound metabolic process|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|interleukin-2 biosynthetic process|positive regulation of cell motility|cellular component assembly|positive regulation of cell death|cell-cell adhesion|detection of abiotic stimulus|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|muscle system process|cytokine production|cellular response to extracellular stimulus|response to wounding|movement of cell or subcellular component|positive regulation of leukocyte migration|cell activation|neuron projection|regulation of signal transduction|regulation of neuronal action potential|negative regulation of biosynthetic process|somatodendritic compartment|protein domain specific binding|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|negative regulation of cell adhesion|regulation of immune response|lymphocyte activation|detection of stimulus involved in sensory perception|regulation of cell activation|cell communication|transmembrane transport|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|negative regulation of signal transduction|positive regulation of cell adhesion|digestion|cytoskeletal protein binding|response to hormone|cell death|negative regulation of leukocyte activation|negative regulation of cell proliferation|regulation of catalytic activity|actin filament-based process|regulation of cell motility|response to inorganic substance|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|response to organic substance|positive regulation of digestive system process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of transmembrane transport|negative regulation of ion transport|organelle organization|response to nutrient|import into cell|actin filament bundle assembly|cytokine metabolic process|regulation of lymphocyte activation|regulation of cellular protein metabolic process|B cell activation|regulation of digestive system process|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|response to gonadotropin|mononuclear cell proliferation|transcription corepressor activity|cytokine biosynthetic process|cell surface receptor signaling pathway|regulation of cellular extravasation|response to lipid|axon|macromolecule modification|cytoskeleton organization|response to cytokine|interleukin-2 production|positive regulation of hydrolase activity|positive regulation of glycoprotein metabolic process|negative regulation of gene expression|regulation of amyloid precursor protein biosynthetic process|response to molecule of bacterial origin|positive regulation of amyloid precursor protein biosynthetic process|regulation of RNA metabolic process|homotypic cell-cell adhesion|positive regulation of neuron death|actin binding|neuron death|protein maturation|LRR domain binding|regulation of muscle system process|leukocyte tethering or rolling|action potential|response to metal ion|regulation of cell migration|negative regulation of calcium ion transport|glycoprotein metabolic process|protein modification process|cellular response to nutrient|ion transport|response to vitamin|negative regulation of lymphocyte activation|phosphatase binding|immune response-activating cell surface receptor signaling pathway|negative regulation of T cell receptor signaling pathway|negative regulation of cell-cell adhesion|sensory perception|regulation of cell-cell adhesion|positive regulation of relaxation of smooth muscle|detection of temperature stimulus|regulation of neutrophil migration|transmission of nerve impulse|regulation of neurological system process|leukocyte cell-cell adhesion|response to vitamin E|negative regulation of ion transmembrane transport|positive regulation of protein metabolic process|proteolysis|regulation of ion transmembrane transport|negative regulation of leukocyte proliferation|immune response-regulating signaling pathway|detection of temperature stimulus involved in sensory perception|regulation of neuron death|actin cytoskeleton organization|regulation of ion transport|positive regulation of smooth muscle contraction|kinase binding|positive regulation of cellular protein metabolic process|detection of mechanical stimulus|T cell activation|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|relaxation of muscle|amyloid precursor protein metabolic process|detection of mechanical stimulus involved in sensory perception|carbohydrate derivative biosynthetic process|positive regulation of cellular extravasation|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of hindgut contraction|gene expression|neutrophil extravasation|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|response to iron ion|lymphocyte proliferation|macromolecule biosynthetic process|positive regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of programmed cell death|cellular response to nutrient levels|RNA metabolic process|response to nutrient levels|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|nucleus|regulation of programmed cell death|response to steroid hormone|response to alcohol|apoptotic signaling pathway|ion transmembrane transport|cellular response to gonadotropin stimulus|negative regulation of leukocyte cell-cell adhesion|actin cytoskeleton|T cell proliferation|glycoprotein biosynthetic process|dephosphorylation|positive regulation of glycoprotein biosynthetic process|sensory perception of temperature stimulus|response to follicle-stimulating hormone|positive regulation of protein modification process|regulation of T cell activation|negative regulation of calcium ion import|response to interleukin-1|neutrophil migration|regulation of T cell receptor signaling pathway|smooth muscle contraction|positive regulation of apoptotic process|sensory perception of pain|sensory perception of mechanical stimulus|regulation of muscle contraction|negative regulation of B cell activation|protein processing|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|positive regulation of phosphatase activity|detection of mechanical stimulus involved in sensory perception of pain|RNA biosynthetic process|positive regulation of leukocyte tethering or rolling|negative regulation of T cell activation|regulation of proteolysis|cation transport|regulation of RNA biosynthetic process|cellular response to vitamin E|positive regulation of proteolysis|positive regulation of neuron apoptotic process|response to estrogen|immune response-regulating cell surface receptor signaling pathway|regulation of relaxation of muscle|negative regulation of RNA biosynthetic process|regulation of peptidase activity|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|leukocyte aggregation|protein phosphatase binding|regulation of B cell activation|positive regulation of neutrophil extravasation|cellular response to vitamin|response to estradiol|regulation of apoptotic process|cellular response to cytokine stimulus|regulation of glycoprotein biosynthetic process|detection of temperature stimulus involved in sensory perception of pain|regulation of hindgut contraction|leucine zipper domain binding|response to iron(II) ion|neuron apoptotic process|B cell proliferation|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|protein kinase binding|relaxation of smooth muscle|cellular protein modification process|antigen receptor-mediated signaling pathway|actin filament organization|positive regulation of peptidase activity|cellular response to lipid|negative regulation of lymphocyte proliferation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of calcium ion import|neuronal action potential|regulation of phosphatase activity|positive regulation of leukocyte cell-cell adhesion|protein dephosphorylation|regulation of protein dephosphorylation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|positive regulation of endopeptidase activity|regulation of smooth muscle contraction|cellular response to interleukin-1|regulation of transcription from RNA polymerase II promoter|positive regulation of protein dephosphorylation|regulation of nucleic acid-templated transcription|cellular response to follicle-stimulating hormone stimulus|regulation of phosphoprotein phosphatase activity|positive regulation of phosphoprotein phosphatase activity|protein phosphatase 1 binding|protein kinase C binding|cellular response to estradiol stimulus|zymogen activation|negative regulation of B cell proliferation|metal ion transport|regulation of B cell proliferation|negative regulation of T cell proliferation|cellular response to estrogen stimulus|positive regulation of dephosphorylation|regulation of calcium ion transport|T cell receptor signaling pathway|regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|actin filament bundle organization|lymphocyte aggregation|regulation of dephosphorylation|regulation of endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|calcium ion import into cell|calcium ion transport|calcium ion import - - - - 12:79574979-79691097 363 394 845 1189 977 1415 1.71377622490413 1.69053312877722 3.59681543055271 5.0295201948976 3.78450939478151 6.26083601460243 2.33370826141135 5.02495520142718 -1.10648651445996 0.000131485519335445 0.00101169296243309 DOWN ENSG00000231340 ACTG1P10 actin gamma 1 pseudogene 10 [Source:HGNC Symbol;Acc:HGNC:155] - - - - - - X:53142832-53143913 0 0 0 5 2 16 0 0 0 0.292857859453004 0.107272027559863 0.980326210299716 0 0.460152032437528 -Inf 0.000133517763428506 0.00102574351760027 DOWN ENSG00000184378 ACTRT3 actin-related protein T3 [Source:HGNC Symbol;Acc:HGNC:24022] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005856|GO:0005634|GO:0001673 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|cytoskeleton|nucleus|male germ cell nucleus - - - - 3:169766921-169769895 123 138 59 55 31 33 4.33948076747737 4.42476193860927 1.876710695898 1.73857891075204 0.897358841685184 1.09112801220265 3.54698446732821 1.24235525487996 1.51351523740906 0.000134533335393401 0.00103168718079491 UP ENSG00000215267 AKR1C7P aldo-keto reductase family 1, member C7, pseudogene [Source:HGNC Symbol;Acc:HGNC:44681] - - - - - - 10:5275173-5288470 5 9 4 22 22 27 0.350893794856423 0.574023951755452 0.253087507923466 1.38324864993881 1.26673404237634 1.77572090818412 0.392668418178447 1.47523453349976 -1.90956085940846 0.000134763846503245 0.00103292422939869 DOWN ENSG00000183054 RGPD6 RANBP2-like and GRIP domain containing 6 [Source:HGNC Symbol;Acc:HGNC:32419] GO:0005623|GO:0005488|GO:0051641|GO:0005622|GO:0005515|GO:0006810|GO:0005737|GO:0045184|GO:0008104|GO:0051649|GO:0016192|GO:0072594|GO:0015031|GO:0046907|GO:0034613|GO:0000042|GO:0072600|GO:0033365|GO:0006605|GO:0048193|GO:0006886|GO:0034067|GO:0006891|GO:0000301 cell|binding|cellular localization|intracellular|protein binding|transport|cytoplasm|establishment of protein localization|protein localization|establishment of localization in cell|vesicle-mediated transport|establishment of protein localization to organelle|protein transport|intracellular transport|cellular protein localization|protein targeting to Golgi|establishment of protein localization to Golgi|protein localization to organelle|protein targeting|Golgi vesicle transport|intracellular protein transport|protein localization to Golgi apparatus|intra-Golgi vesicle-mediated transport|retrograde transport, vesicle recycling within Golgi K12172 E3 SUMO-protein ligase RanBP2[-] hsa03013 RNA transport - Homo sapiens (human) 2:110513812-110577185 132 134 134 86 65 56 0.52601510539125 0.48529651730017 0.48144097360703 0.307056558478488 0.212522246364305 0.209142885381388 0.49758419876615 0.242907230074727 1.03453524003661 0.000135127041961577 0.00103544217420968 UP ENSG00000165650 PDZD8 PDZ domain containing 8 [Source:HGNC Symbol;Acc:HGNC:26974] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043167|GO:0009653|GO:0016043|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0016032|GO:0051128|GO:0043169|GO:0007154|GO:0007165|GO:0048869|GO:0006996|GO:0000902|GO:0046872|GO:0007010|GO:0022604|GO:0035556 developmental process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|ion binding|anatomical structure morphogenesis|cellular component organization|regulation of developmental process|intracellular|protein binding|anatomical structure development|viral process|regulation of cellular component organization|cation binding|cell communication|signal transduction|cellular developmental process|organelle organization|cell morphogenesis|metal ion binding|cytoskeleton organization|regulation of cell morphogenesis|intracellular signal transduction - - - - 10:117277274-117375467 193 236 306 359 594 708 1.17297079886677 1.3035315139325 1.67673768572596 1.95489206344318 2.96199657356976 4.03266871161252 1.38441333284174 2.98318578287515 -1.10757908589608 0.000136380137153487 0.00104370484864911 DOWN ENSG00000233538 AC017104.2 - - - - - - - 2:231452195-231453153 7 5 6 1 0 0 0.87177477308381 0.565962913826087 0.673711816866692 0.111529566022556 0 0 0.703816501258863 0.0371765220075187 4.24273562648347 0.000136463853977754 0.0010440778822788 UP ENSG00000267026 RP11-92C4.3 - - - - - - - 9:98847172-98872415 23 31 31 9 8 14 0.140546936699304 0.172161090973482 0.170791831178408 0.0492739818897279 0.0401115632885297 0.0801780812706338 0.161166619617065 0.0565212088162971 1.51168874185108 0.000138175752519558 0.00105484603524331 UP ENSG00000217648 RP1-95L4.4 - - - - - - - 6:143342246-143343383 1 0 3 11 7 14 0.0621851436051088 0 0.168102620222558 0.612616273786607 0.357001958737845 0.815590042872458 0.0767625879425556 0.595069425132303 -2.95458273765111 0.000138244885249885 0.00105500071683284 DOWN ENSG00000267303 CTD-2369P2.12 - GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0016071|GO:0006397|GO:0008380|GO:0000375|GO:0000398 cell|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|gene expression|RNA metabolic process|nucleus|RNA processing|mRNA metabolic process|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|mRNA splicing, via spliceosome - - - - 19:10315471-10320678 0 0 0 0 322 0 0 0 0 0 10.1017731971134 0 0 3.36725773237113 -Inf 0.00013864586097585 0.00105779032291669 DOWN ENSG00000213638 ADAT3 adenosine deaminase, tRNA-specific 3 [Source:HGNC Symbol;Acc:HGNC:25151] GO:0008152|GO:0005488|GO:0003824|GO:0043167|GO:0043169|GO:0046872|GO:0046914|GO:0008270 metabolic process|binding|catalytic activity|ion binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 19:1905378-1913447 151 321 148 46 126 33 4.10344408847086 7.92787337381451 3.62615624360301 1.12001190299282 2.80938460345218 0.840457804251366 5.21915790196279 1.58995143689879 1.71483434949964 0.0001389360004053 0.00105946241535117 UP ENSG00000163220 S100A9 S100 calcium binding protein A9 [Source:HGNC Symbol;Acc:HGNC:10499] GO:0016209|GO:0040011|GO:0032502|GO:0040007|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0071704|GO:0050900|GO:0043167|GO:0006955|GO:0044237|GO:0006914|GO:0048870|GO:0023051|GO:0016043|GO:0051707|GO:0045927|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0040008|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0050817|GO:0098869|GO:0016337|GO:0006935|GO:0045087|GO:0006725|GO:0005504|GO:0048468|GO:0006810|GO:1901360|GO:0010941|GO:0007275|GO:0005102|GO:0034641|GO:0043168|GO:0030307|GO:0006952|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0010942|GO:0098542|GO:0098609|GO:0043231|GO:0043169|GO:0009620|GO:0005737|GO:0001816|GO:0007267|GO:0009611|GO:0006928|GO:0032403|GO:0042592|GO:0043177|GO:0009966|GO:0019725|GO:0010646|GO:0006139|GO:0043085|GO:0009617|GO:0007154|GO:0061024|GO:0016477|GO:0007165|GO:0070062|GO:0008092|GO:0008219|GO:0030595|GO:0051047|GO:0050790|GO:0051238|GO:0002523|GO:0048869|GO:0030029|GO:0050820|GO:0009967|GO:0044249|GO:0019538|GO:0001558|GO:0031323|GO:0010256|GO:0050878|GO:0006996|GO:0051090|GO:0009636|GO:1902533|GO:0015631|GO:2001235|GO:0032268|GO:0005829|GO:0050832|GO:0035325|GO:0010468|GO:0030193|GO:0034645|GO:0006518|GO:0046872|GO:0002793|GO:0043412|GO:0007010|GO:0007417|GO:0021782|GO:0051345|GO:0050727|GO:0048878|GO:0007596|GO:0051252|GO:0051604|GO:0008017|GO:0010628|GO:0007009|GO:0036211|GO:0042060|GO:0042886|GO:0006954|GO:0055082|GO:0032602|GO:0051091|GO:0051046|GO:0060326|GO:0007599|GO:0007159|GO:0051247|GO:0050729|GO:0006508|GO:0030036|GO:0032270|GO:0012501|GO:0043603|GO:0035556|GO:0033043|GO:0044267|GO:0031406|GO:0032119|GO:0010467|GO:0050544|GO:0007399|GO:0046903|GO:0030194|GO:0031328|GO:0036041|GO:0051246|GO:0042742|GO:0009059|GO:0030154|GO:0043068|GO:1902531|GO:0016070|GO:0005856|GO:0010557|GO:0005634|GO:0043067|GO:0090303|GO:0050786|GO:0097190|GO:0071621|GO:0002790|GO:0045893|GO:0097193|GO:0043043|GO:2001242|GO:0045113|GO:1990266|GO:0031532|GO:0010001|GO:0043065|GO:2001244|GO:0016485|GO:0032774|GO:0030162|GO:0045112|GO:2001141|GO:0045862|GO:0014002|GO:0015833|GO:0010608|GO:0051092|GO:0052547|GO:0005509|GO:0030593|GO:0070486|GO:0006412|GO:0050543|GO:0051493|GO:0006417|GO:0042981|GO:0046914|GO:0050801|GO:0022008|GO:0006464|GO:0010952|GO:0035662|GO:0048708|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0061041|GO:0010950|GO:0070488|GO:0043281|GO:1903506|GO:0018193|GO:0042063|GO:0031638|GO:0043280|GO:0006919|GO:0008270|GO:0030003|GO:0052548|GO:0018119|GO:2001056|GO:0055065|GO:0006875|GO:2000116|GO:0097202|GO:0006882|GO:0055069|GO:0035606 antioxidant activity|locomotion|developmental process|growth|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|organic substance metabolic process|leukocyte migration|ion binding|immune response|cellular metabolic process|autophagy|cell motility|regulation of signaling|cellular component organization|response to other organism|positive regulation of growth|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|regulation of growth|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|extracellular space|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|coagulation|cellular oxidant detoxification|single organismal cell-cell adhesion|chemotaxis|innate immune response|cellular aromatic compound metabolic process|fatty acid binding|cell development|transport|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|receptor binding|cellular nitrogen compound metabolic process|anion binding|positive regulation of cell growth|defense response|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell death|defense response to other organism|cell-cell adhesion|intracellular membrane-bounded organelle|cation binding|response to fungus|cytoplasm|cytokine production|cell-cell signaling|response to wounding|movement of cell or subcellular component|protein complex binding|homeostatic process|organic acid binding|regulation of signal transduction|cellular homeostasis|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|cell communication|membrane organization|cell migration|signal transduction|extracellular exosome|cytoskeletal protein binding|cell death|leukocyte chemotaxis|positive regulation of secretion|regulation of catalytic activity|sequestering of metal ion|leukocyte migration involved in inflammatory response|cellular developmental process|actin filament-based process|positive regulation of coagulation|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of cell growth|regulation of cellular metabolic process|endomembrane system organization|regulation of body fluid levels|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|response to toxic substance|positive regulation of intracellular signal transduction|tubulin binding|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cytosol|defense response to fungus|Toll-like receptor binding|regulation of gene expression|regulation of blood coagulation|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|positive regulation of peptide secretion|macromolecule modification|cytoskeleton organization|central nervous system development|glial cell development|positive regulation of hydrolase activity|regulation of inflammatory response|chemical homeostasis|blood coagulation|regulation of RNA metabolic process|protein maturation|microtubule binding|positive regulation of gene expression|plasma membrane organization|protein modification process|wound healing|amide transport|inflammatory response|cellular chemical homeostasis|chemokine production|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of secretion|cell chemotaxis|hemostasis|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|positive regulation of inflammatory response|proteolysis|actin cytoskeleton organization|positive regulation of cellular protein metabolic process|programmed cell death|cellular amide metabolic process|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|carboxylic acid binding|sequestering of zinc ion|gene expression|arachidonic acid binding|nervous system development|secretion|positive regulation of blood coagulation|positive regulation of cellular biosynthetic process|long-chain fatty acid binding|regulation of protein metabolic process|defense response to bacterium|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|positive regulation of wound healing|RAGE receptor binding|apoptotic signaling pathway|granulocyte chemotaxis|peptide secretion|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|peptide biosynthetic process|regulation of intrinsic apoptotic signaling pathway|regulation of integrin biosynthetic process|neutrophil migration|actin cytoskeleton reorganization|glial cell differentiation|positive regulation of apoptotic process|positive regulation of intrinsic apoptotic signaling pathway|protein processing|RNA biosynthetic process|regulation of proteolysis|integrin biosynthetic process|regulation of RNA biosynthetic process|positive regulation of proteolysis|astrocyte development|peptide transport|posttranscriptional regulation of gene expression|positive regulation of NF-kappaB transcription factor activity|regulation of peptidase activity|calcium ion binding|neutrophil chemotaxis|leukocyte aggregation|translation|icosatetraenoic acid binding|regulation of cytoskeleton organization|regulation of translation|regulation of apoptotic process|transition metal ion binding|ion homeostasis|neurogenesis|cellular protein modification process|positive regulation of peptidase activity|Toll-like receptor 4 binding|astrocyte differentiation|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of wound healing|positive regulation of endopeptidase activity|neutrophil aggregation|regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of nucleic acid-templated transcription|peptidyl-amino acid modification|gliogenesis|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|zinc ion binding|cellular cation homeostasis|regulation of endopeptidase activity|peptidyl-cysteine S-nitrosylation|positive regulation of cysteine-type endopeptidase activity|metal ion homeostasis|cellular metal ion homeostasis|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|cellular zinc ion homeostasis|zinc ion homeostasis|peptidyl-cysteine S-trans-nitrosylation - - - - 1:153357854-153361027 112 141 250 349 318 682 13.7306007207762 15.7097747275679 27.6327773120554 38.3348010404624 31.9863843102603 78.3580419486764 19.0243842534665 49.559742433133 -1.3813189297041 0.000139643310965487 0.00106376917722982 DOWN ENSG00000250590 RP11-565A3.2 - - - - - - - 4:187532878-187672641 5 7 1 30 29 12 0.201424228482502 0.256287892489383 0.0363010693734877 1.08277987471127 0.958472677910073 0.453017916448189 0.164671063448458 0.831423489689844 -2.33599644597737 0.000139630961123107 0.00106376917722982 DOWN ENSG00000259408 RP11-3D4.3 - - - - - - - 15:33851785-33856809 1 0 0 7 8 5 0.0734094330110102 0 0 0.460201150562054 0.481671635506245 0.343878883442938 0.0244698110036701 0.428583889837079 -4.1305027574584 0.000139625676204906 0.00106376917722982 DOWN ENSG00000187193 MT1X metallothionein 1X [Source:HGNC Symbol;Acc:HGNC:7405] GO:0040007|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0043229|GO:0043167|GO:0045926|GO:0043227|GO:0040008|GO:0005622|GO:0005515|GO:0043231|GO:0043169|GO:0005737|GO:0010035|GO:0010033|GO:0046872|GO:0034097|GO:0010038|GO:0048471|GO:0010043|GO:0071241|GO:0071310|GO:0005634|GO:0046686|GO:0071294|GO:0071345|GO:0046914|GO:0071248|GO:0071276|GO:0008270|GO:0036018 growth|cell|cellular process|response to stimulus|binding|cellular response to stimulus|intracellular organelle|ion binding|negative regulation of growth|membrane-bounded organelle|regulation of growth|intracellular|protein binding|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to inorganic substance|response to organic substance|metal ion binding|response to cytokine|response to metal ion|perinuclear region of cytoplasm|response to zinc ion|cellular response to inorganic substance|cellular response to organic substance|nucleus|response to cadmium ion|cellular response to zinc ion|cellular response to cytokine stimulus|transition metal ion binding|cellular response to metal ion|cellular response to cadmium ion|zinc ion binding|cellular response to erythropoietin K14739 metallothionein 1/2[-] hsa04978 Mineral absorption - Homo sapiens (human) 16:56682424-56684196 659 444 1523 420 427 353 15.4101062689851 9.43590842063557 32.1095769017288 8.79968940162048 8.19249714059993 7.73614208986822 18.9851971971165 8.24277621069621 1.20367275244615 0.000139742462317808 0.00106425292602955 UP ENSG00000139438 FAM222A family with sequence similarity 222 member A [Source:HGNC Symbol;Acc:HGNC:25915] - - - - - - 12:109714228-109770507 26 33 24 81 95 55 0.283730160074235 0.327292717258124 0.236131826529989 0.791991478806464 0.850605313978281 0.562502174680177 0.282384901287449 0.735032989154974 -1.38014604941927 0.000140147519739123 0.00106679348656088 DOWN ENSG00000115233 PSMD14 proteasome 26S subunit, non-ATPase 14 [Source:HGNC Symbol;Acc:HGNC:16889] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0019882|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0016787|GO:0030234|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0016032|GO:0002757|GO:0051726|GO:0007049|GO:0006281|GO:0006935|GO:0045087|GO:0006725|GO:0048468|GO:0019884|GO:0022402|GO:1901360|GO:0010941|GO:0006082|GO:0007275|GO:0034641|GO:0008047|GO:0044281|GO:0006952|GO:0031982|GO:0031325|GO:0046483|GO:0033554|GO:0045786|GO:0043231|GO:0043169|GO:0008233|GO:0010243|GO:0005737|GO:0006520|GO:0002218|GO:0006928|GO:0032403|GO:0009966|GO:0005838|GO:0000502|GO:0045787|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0022624|GO:0050776|GO:0007154|GO:0044092|GO:0007165|GO:0050778|GO:0009968|GO:0070062|GO:0042180|GO:0009725|GO:0008219|GO:0050790|GO:0048002|GO:0030030|GO:0043086|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0043487|GO:0008541|GO:0010033|GO:0031324|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0030111|GO:0000902|GO:0005829|GO:0045732|GO:0031175|GO:0010468|GO:0000075|GO:0030178|GO:0090068|GO:0046872|GO:0000725|GO:0007166|GO:0016504|GO:1903047|GO:0043412|GO:0002758|GO:0034097|GO:0030163|GO:0051345|GO:0043069|GO:0009308|GO:0044770|GO:0044265|GO:1901652|GO:0007050|GO:0000904|GO:0071417|GO:0006302|GO:0051347|GO:0036211|GO:0032269|GO:0000278|GO:0006521|GO:0002429|GO:0031981|GO:0051351|GO:0007346|GO:0043434|GO:0044344|GO:0010564|GO:0051247|GO:0045930|GO:0070848|GO:0006508|GO:0005654|GO:0006259|GO:0002764|GO:0002474|GO:0010565|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0042176|GO:0010467|GO:0032990|GO:0070628|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030177|GO:0030154|GO:0048858|GO:0072395|GO:1902531|GO:0032870|GO:0005634|GO:0043067|GO:0045089|GO:0097305|GO:0006974|GO:0031597|GO:0045088|GO:0043488|GO:0010948|GO:0048666|GO:0030182|GO:0008237|GO:0007411|GO:0016055|GO:0006303|GO:0044257|GO:0000724|GO:0019221|GO:0042590|GO:0031401|GO:0008543|GO:0090090|GO:0071156|GO:0010498|GO:0051436|GO:1901653|GO:0043408|GO:0060828|GO:0007093|GO:0072331|GO:0042770|GO:0038061|GO:1903364|GO:0044772|GO:0030162|GO:0051444|GO:0045862|GO:0051439|GO:0071363|GO:0016310|GO:0010608|GO:0002768|GO:0044774|GO:0038179|GO:0052547|GO:0000077|GO:0061133|GO:0061564|GO:1901990|GO:0045471|GO:0051603|GO:0007167|GO:0006576|GO:0071375|GO:0043410|GO:0006310|GO:0070646|GO:0042981|GO:0071345|GO:0043066|GO:0019752|GO:0032868|GO:1901987|GO:0051438|GO:0034612|GO:0051443|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050851|GO:0090263|GO:0048812|GO:0010952|GO:0043549|GO:0006915|GO:0044773|GO:1901991|GO:0071158|GO:0033674|GO:0048011|GO:0000186|GO:2000045|GO:0007265|GO:0002223|GO:0045859|GO:1903052|GO:0010950|GO:0045860|GO:0007409|GO:0044819|GO:0019941|GO:0006468|GO:0048699|GO:0071356|GO:0060070|GO:0044783|GO:0016579|GO:0043405|GO:0042325|GO:0002479|GO:0001932|GO:1902806|GO:0032869|GO:0038093|GO:2000134|GO:0000082|GO:0033209|GO:0001934|GO:0050852|GO:0031571|GO:0061136|GO:0042327|GO:1902807|GO:0006977|GO:0030330|GO:0051437|GO:0043161|GO:0072422|GO:0006595|GO:0007169|GO:0052548|GO:0032446|GO:0048010|GO:0072431|GO:0006511|GO:0031398|GO:0070536|GO:2000058|GO:0038095|GO:0031396|GO:0031397|GO:2000060|GO:0071900|GO:0032147|GO:0008286|GO:0031145|GO:0038127|GO:0007173|GO:0042787|GO:0016567|GO:0000209 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|antigen processing and presentation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|enzyme regulator activity|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|protein complex|anatomical structure development|regulation of metabolic process|viral process|immune response-activating signal transduction|regulation of cell cycle|cell cycle|DNA repair|chemotaxis|innate immune response|cellular aromatic compound metabolic process|cell development|antigen processing and presentation of exogenous antigen|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|enzyme activator activity|small molecule metabolic process|defense response|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|peptidase activity|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|activation of innate immune response|movement of cell or subcellular component|protein complex binding|regulation of signal transduction|proteasome regulatory particle|proteasome complex|positive regulation of cell cycle|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|proteasome accessory complex|regulation of immune response|cell communication|negative regulation of molecular function|signal transduction|positive regulation of immune response|negative regulation of signal transduction|extracellular exosome|cellular ketone metabolic process|response to hormone|cell death|regulation of catalytic activity|antigen processing and presentation of peptide antigen|cell projection organization|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of RNA stability|proteasome regulatory particle, lid subcomplex|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|cytosol|positive regulation of protein catabolic process|neuron projection development|regulation of gene expression|cell cycle checkpoint|negative regulation of Wnt signaling pathway|positive regulation of cell cycle process|metal ion binding|recombinational repair|cell surface receptor signaling pathway|peptidase activator activity|mitotic cell cycle process|macromolecule modification|innate immune response-activating signal transduction|response to cytokine|protein catabolic process|positive regulation of hydrolase activity|negative regulation of programmed cell death|amine metabolic process|cell cycle phase transition|cellular macromolecule catabolic process|response to peptide|cell cycle arrest|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|double-strand break repair|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|regulation of cellular amino acid metabolic process|immune response-activating cell surface receptor signaling pathway|nuclear lumen|positive regulation of ligase activity|regulation of mitotic cell cycle|response to peptide hormone|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|response to growth factor|proteolysis|nucleoplasm|DNA metabolic process|immune response-regulating signaling pathway|antigen processing and presentation of peptide antigen via MHC class I|regulation of cellular ketone metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|gene expression|cell part morphogenesis|proteasome binding|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|cell differentiation|cell projection morphogenesis|signal transduction involved in cell cycle checkpoint|regulation of intracellular signal transduction|cellular response to hormone stimulus|nucleus|regulation of programmed cell death|positive regulation of innate immune response|response to alcohol|cellular response to DNA damage stimulus|cytosolic proteasome complex|regulation of innate immune response|regulation of mRNA stability|negative regulation of cell cycle process|neuron development|neuron differentiation|metallopeptidase activity|axon guidance|Wnt signaling pathway|double-strand break repair via nonhomologous end joining|cellular protein catabolic process|double-strand break repair via homologous recombination|cytokine-mediated signaling pathway|antigen processing and presentation of exogenous peptide antigen via MHC class I|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of cell cycle arrest|proteasomal protein catabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|cellular response to peptide|regulation of MAPK cascade|regulation of canonical Wnt signaling pathway|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|NIK/NF-kappaB signaling|positive regulation of cellular protein catabolic process|mitotic cell cycle phase transition|regulation of proteolysis|negative regulation of ubiquitin-protein transferase activity|positive regulation of proteolysis|regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|cellular response to growth factor stimulus|phosphorylation|posttranscriptional regulation of gene expression|immune response-regulating cell surface receptor signaling pathway|mitotic DNA integrity checkpoint|neurotrophin signaling pathway|regulation of peptidase activity|DNA damage checkpoint|endopeptidase activator activity|axon development|regulation of mitotic cell cycle phase transition|response to ethanol|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|cellular biogenic amine metabolic process|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|DNA recombination|protein modification by small protein removal|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|carboxylic acid metabolic process|response to insulin|regulation of cell cycle phase transition|regulation of ubiquitin-protein transferase activity|response to tumor necrosis factor|positive regulation of ubiquitin-protein transferase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|antigen receptor-mediated signaling pathway|positive regulation of canonical Wnt signaling pathway|neuron projection morphogenesis|positive regulation of peptidase activity|regulation of kinase activity|apoptotic process|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|regulation of G1/S transition of mitotic cell cycle|Ras protein signal transduction|stimulatory C-type lectin receptor signaling pathway|regulation of protein kinase activity|positive regulation of proteolysis involved in cellular protein catabolic process|positive regulation of endopeptidase activity|positive regulation of protein kinase activity|axonogenesis|mitotic G1/S transition checkpoint|modification-dependent protein catabolic process|protein phosphorylation|generation of neurons|cellular response to tumor necrosis factor|canonical Wnt signaling pathway|G1 DNA damage checkpoint|protein deubiquitination|regulation of MAP kinase activity|regulation of phosphorylation|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|regulation of protein phosphorylation|regulation of cell cycle G1/S phase transition|cellular response to insulin stimulus|Fc receptor signaling pathway|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|tumor necrosis factor-mediated signaling pathway|positive regulation of protein phosphorylation|T cell receptor signaling pathway|mitotic G1 DNA damage checkpoint|regulation of proteasomal protein catabolic process|positive regulation of phosphorylation|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition|proteasome-mediated ubiquitin-dependent protein catabolic process|signal transduction involved in DNA damage checkpoint|polyamine metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|signal transduction involved in mitotic G1 DNA damage checkpoint|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein K63-linked deubiquitination|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|Fc-epsilon receptor signaling pathway|regulation of protein ubiquitination|negative regulation of protein ubiquitination|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination K03030 26S proteasome regulatory subunit N11[-] hsa05169|hsa03050 Epstein-Barr virus infection - Homo sapiens (human)|Proteasome - Homo sapiens (human) 2:161308038-161411717 813 871 686 1871 2043 1178 6.76816173299853 6.58989424324387 5.14894774011203 13.9556982275079 13.9545685590705 9.19082145266068 6.16900123878481 12.3670294130797 -1.00339016240644 0.00014030761154383 0.00106773985088695 DOWN ENSG00000224081 LINC01057 long intergenic non-protein coding RNA 1057 [Source:HGNC Symbol;Acc:HGNC:49057] - - - - - - 1:94613814-94855426 33 30 93 124 139 256 0.108305431666719 0.0894826271225391 0.275191015859046 0.364634586850987 0.374300624195657 0.787420141938843 0.157659691549435 0.508785117661829 -1.69024261423405 0.000140612356698466 0.00106978626322018 DOWN ENSG00000175920 DOK7 docking protein 7 [Source:HGNC Symbol;Acc:HGNC:26594] GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0044877|GO:0050794|GO:0071704|GO:0044237|GO:0008289|GO:0071944|GO:0009893|GO:0005515|GO:0005886|GO:0019222|GO:0005102|GO:0031325|GO:0019899|GO:0032403|GO:0043085|GO:0050790|GO:0019538|GO:0031323|GO:0032268|GO:0043412|GO:0051347|GO:0036211|GO:0005158|GO:0051247|GO:0019900|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0031401|GO:0016310|GO:0019901|GO:0006464|GO:0043549|GO:0033674|GO:0045859|GO:0045860|GO:0006468|GO:0042325|GO:0001932|GO:0018193|GO:0001934|GO:0042327|GO:0050731|GO:0050730|GO:0061097|GO:0061098|GO:0018108 synapse|cell|membrane|cellular process|metabolic process|cell junction|binding|macromolecular complex binding|regulation of cellular process|organic substance metabolic process|cellular metabolic process|lipid binding|cell periphery|positive regulation of metabolic process|protein binding|plasma membrane|regulation of metabolic process|receptor binding|positive regulation of cellular metabolic process|enzyme binding|protein complex binding|positive regulation of catalytic activity|regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|positive regulation of transferase activity|protein modification process|insulin receptor binding|positive regulation of protein metabolic process|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|positive regulation of protein modification process|phosphorylation|protein kinase binding|cellular protein modification process|regulation of kinase activity|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|peptidyl-tyrosine phosphorylation - - - - 4:3463311-3501473 14 13 20 33 83 44 0.137336866207628 0.11590144940865 0.176891005399289 0.290039101193659 0.668028778385752 0.404510522863903 0.143376440338522 0.454192800814438 -1.66349685936513 0.00014070823186245 0.00106997033979154 DOWN ENSG00000143341 HMCN1 hemicentin 1 [Source:HGNC Symbol;Acc:HGNC:19194] GO:0031012|GO:0005623|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:0005604|GO:1903561|GO:0005578|GO:0043167|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005938|GO:0050877|GO:0031982|GO:0043169|GO:0005737|GO:0070062|GO:0046872|GO:0007600|GO:0050953|GO:0005509|GO:0007601 extracellular matrix|cell|extracellular region|cell junction|response to stimulus|binding|basement membrane|extracellular vesicle|proteinaceous extracellular matrix|ion binding|membrane-bounded organelle|cell periphery|intracellular|protein binding|cell cortex|neurological system process|vesicle|cation binding|cytoplasm|extracellular exosome|metal ion binding|sensory perception|sensory perception of light stimulus|calcium ion binding|visual perception - - - - 1:185734551-186190949 3 2 5 16 12 27 0.0108144621309016 0.00655157218640199 0.0162474846270929 0.0516702941909457 0.0354888216187293 0.0912064547999793 0.0112045063147988 0.0594551902032181 -2.40772367382737 0.00014199694744297 0.00107922018048941 DOWN ENSG00000245937 LINC01184 long intergenic non-protein coding RNA 1184 [Source:HGNC Symbol;Acc:HGNC:49565] - - - - - - 5:127940426-128083172 72 95 107 218 210 174 0.515129116624201 0.61771256419232 0.690207817615455 1.3974488763837 1.23272870941247 1.16670380777601 0.607683166143992 1.26562713119073 -1.05846119979649 0.000142365206895583 0.00108146841899764 DOWN ENSG00000101230 ISM1 isthmin 1, angiogenesis inhibitor [Source:HGNC Symbol;Acc:HGNC:16213] GO:0005576 extracellular region - - - - 20:13221771-13300651 7 4 6 27 20 21 0.190963390324568 0.0991705392658226 0.147577443879784 0.659950235741811 0.447644218876456 0.536884568620472 0.145903791156725 0.548159674412913 -1.90957882896819 0.000146279523477699 0.00110866435488785 DOWN ENSG00000279159 RP3-394A18.1 - - - - - - - 22:29978950-30028236 89 86 203 266 309 361 0.127733180689771 0.112173757355895 0.262677327477576 0.342052259815157 0.363864856537358 0.485567924637805 0.167528088507747 0.397161680330107 -1.24532342832828 0.000148597751759717 0.00112594854848594 DOWN ENSG00000154814 OXNAD1 oxidoreductase NAD-binding domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25128] GO:0005623|GO:0008152|GO:0003824|GO:0016491|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0055114|GO:0005739 cell|metabolic process|catalytic activity|oxidoreductase activity|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|oxidation-reduction process|mitochondrion - - - - 3:16265160-16350299 68 73 91 157 201 156 0.393720312950963 0.384137143032655 0.4750459082276 0.814475010977065 0.954870441769473 0.846512693822645 0.417634454737073 0.871952715523061 -1.06200916348997 0.000149411726305763 0.00113182889549156 DOWN ENSG00000196118 CCDC189 coiled-coil domain containing 189 [Source:HGNC Symbol;Acc:HGNC:28078] - - - - - - 16:30757423-30762710 32 28 39 99 93 65 0.19871886017374 0.158023391994903 0.218357532586688 0.55082784604815 0.473843851407905 0.378293177381695 0.191699928251777 0.46765495827925 -1.28659468667087 0.000150063806548018 0.00113648018282205 DOWN ENSG00000167992 VWCE von Willebrand factor C and EGF domains [Source:HGNC Symbol;Acc:HGNC:26487] GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0043167|GO:0023051|GO:0005515|GO:0008284|GO:0042127|GO:0043169|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0046872|GO:0005509 signaling|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|ion binding|regulation of signaling|protein binding|positive regulation of cell proliferation|regulation of cell proliferation|cation binding|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|metal ion binding|calcium ion binding - - - - 11:61258286-61295424 25 16 12 2 8 2 0.191825411121323 0.111573579918116 0.0830173146719343 0.0137500493777708 0.0503667921279987 0.0143802463125541 0.128805435237124 0.0261656959394412 2.29944493601196 0.000151257937789518 0.00114436251261233 UP ENSG00000151388 ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 [Source:HGNC Symbol;Acc:HGNC:14605] GO:0040011|GO:0032502|GO:0031012|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0005578|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0007155|GO:0009605|GO:0023057|GO:0016787|GO:0050793|GO:0005515|GO:0048856|GO:0045595|GO:0035239|GO:0061037|GO:0009888|GO:0035295|GO:0007275|GO:0045596|GO:0048513|GO:0006952|GO:0090287|GO:0043169|GO:0008233|GO:0009611|GO:0006928|GO:0031589|GO:0009966|GO:0048729|GO:0010646|GO:0090288|GO:0007154|GO:0016477|GO:0007165|GO:0009968|GO:0048869|GO:0019538|GO:0010033|GO:1901509|GO:0071773|GO:0051216|GO:0046872|GO:0007166|GO:1902548|GO:0002009|GO:0034097|GO:0030163|GO:0050727|GO:1902203|GO:0044265|GO:0009100|GO:0007160|GO:0006954|GO:0032330|GO:1902202|GO:0070848|GO:0006508|GO:0032331|GO:0060429|GO:0044267|GO:0060562|GO:0071310|GO:0030154|GO:0001501|GO:0061448|GO:0061035|GO:2001113|GO:0008237|GO:0035728|GO:0003158|GO:0044257|GO:0070555|GO:0002062|GO:0071363|GO:0006516|GO:0051603|GO:0007167|GO:0061154|GO:0004175|GO:0071345|GO:0006029|GO:0046914|GO:0034612|GO:0071347|GO:0030167|GO:0071356|GO:0035729|GO:0035924|GO:0008270|GO:0004222|GO:0007169|GO:0048012 locomotion|developmental process|extracellular matrix|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|proteinaceous extracellular matrix|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cell adhesion|response to external stimulus|negative regulation of signaling|hydrolase activity|regulation of developmental process|protein binding|anatomical structure development|regulation of cell differentiation|tube morphogenesis|negative regulation of cartilage development|tissue development|tube development|multicellular organism development|negative regulation of cell differentiation|animal organ development|defense response|regulation of cellular response to growth factor stimulus|cation binding|peptidase activity|response to wounding|movement of cell or subcellular component|cell-substrate adhesion|regulation of signal transduction|tissue morphogenesis|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|cell communication|cell migration|signal transduction|negative regulation of signal transduction|cellular developmental process|protein metabolic process|response to organic substance|regulation of endothelial tube morphogenesis|cellular response to BMP stimulus|cartilage development|metal ion binding|cell surface receptor signaling pathway|negative regulation of cellular response to vascular endothelial growth factor stimulus|morphogenesis of an epithelium|response to cytokine|protein catabolic process|regulation of inflammatory response|negative regulation of hepatocyte growth factor receptor signaling pathway|cellular macromolecule catabolic process|glycoprotein metabolic process|cell-matrix adhesion|inflammatory response|regulation of chondrocyte differentiation|regulation of hepatocyte growth factor receptor signaling pathway|response to growth factor|proteolysis|negative regulation of chondrocyte differentiation|epithelium development|cellular protein metabolic process|epithelial tube morphogenesis|cellular response to organic substance|cell differentiation|skeletal system development|connective tissue development|regulation of cartilage development|negative regulation of cellular response to hepatocyte growth factor stimulus|metallopeptidase activity|response to hepatocyte growth factor|endothelium development|cellular protein catabolic process|response to interleukin-1|chondrocyte differentiation|cellular response to growth factor stimulus|glycoprotein catabolic process|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|endothelial tube morphogenesis|endopeptidase activity|cellular response to cytokine stimulus|proteoglycan metabolic process|transition metal ion binding|response to tumor necrosis factor|cellular response to interleukin-1|proteoglycan catabolic process|cellular response to tumor necrosis factor|cellular response to hepatocyte growth factor stimulus|cellular response to vascular endothelial growth factor stimulus|zinc ion binding|metalloendopeptidase activity|transmembrane receptor protein tyrosine kinase signaling pathway|hepatocyte growth factor receptor signaling pathway - - - - 5:33523535-33892192 0 3 4 18 22 7 0 0.0172672393604045 0.0228370072497408 0.102120779582041 0.114302024412797 0.0415424522777216 0.0133680822033818 0.0859884187575199 -2.68534985532462 0.000151465718009169 0.00114535398820814 DOWN ENSG00000176472 ZNF575 zinc finger protein 575 [Source:HGNC Symbol;Acc:HGNC:27606] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:43525497-43536130 18 21 24 53 62 54 0.239111811082792 0.253533102031611 0.287437840294345 0.630814837717215 0.675746635457024 0.672272929746326 0.260027584469583 0.659611467640188 -1.34295180430487 0.000151519880590634 0.00114547341482725 DOWN ENSG00000131242 RAB11FIP4 RAB11 family interacting protein 4 (class II) [Source:HGNC Symbol;Acc:HGNC:30267] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0030496|GO:0050794|GO:0043229|GO:0043167|GO:0009986|GO:0043227|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0042802|GO:0016032|GO:0051726|GO:0007049|GO:0060041|GO:0006810|GO:0022402|GO:0007275|GO:0048513|GO:0031982|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0007423|GO:0003407|GO:0046983|GO:0045787|GO:0010008|GO:0051301|GO:0032154|GO:0005768|GO:0090068|GO:0046872|GO:0001654|GO:0031410|GO:0016023|GO:0055037|GO:0010564|GO:0048471|GO:0031988|GO:0070314|GO:0051020|GO:0000910|GO:0042803|GO:0055038|GO:0030139|GO:0043010|GO:1903452|GO:0005509|GO:0031267|GO:0017016|GO:0030306|GO:0017137 developmental process|cell|membrane|cellular process|extracellular region|binding|midbody|regulation of cellular process|intracellular organelle|ion binding|cell surface|membrane-bounded organelle|extracellular space|intracellular|protein binding|endomembrane system|anatomical structure development|organelle membrane|identical protein binding|viral process|regulation of cell cycle|cell cycle|retina development in camera-type eye|transport|cell cycle process|multicellular organism development|animal organ development|vesicle|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|sensory organ development|neural retina development|protein dimerization activity|positive regulation of cell cycle|endosome membrane|cell division|cleavage furrow|endosome|positive regulation of cell cycle process|metal ion binding|eye development|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|recycling endosome|regulation of cell cycle process|perinuclear region of cytoplasm|membrane-bounded vesicle|G1 to G0 transition|GTPase binding|cytokinesis|protein homodimerization activity|recycling endosome membrane|endocytic vesicle|camera-type eye development|positive regulation of G1 to G0 transition|calcium ion binding|small GTPase binding|Ras GTPase binding|ADP-ribosylation factor binding|Rab GTPase binding K12485 Rab11 family-interacting protein 3/4[-] hsa04144 Endocytosis - Homo sapiens (human) 17:31391624-31538217 916 967 1531 265 301 843 3.75470391164279 3.60235918087928 5.65809205213555 0.973250329489993 1.01231243712863 3.23845019577311 4.33838504821921 1.74133765413058 1.31696212743974 0.000152591130204092 0.00115327989901594 UP ENSG00000153208 MERTK MER proto-oncogene, tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7027] GO:0040011|GO:0032502|GO:0004871|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0002683|GO:0097159|GO:0004872|GO:0048523|GO:0050794|GO:0045321|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0050900|GO:0043167|GO:0019953|GO:0044237|GO:0038023|GO:0003006|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0032504|GO:0031224|GO:0005615|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0005929|GO:0048609|GO:0050817|GO:0060041|GO:0048468|GO:0006810|GO:0051130|GO:0016028|GO:0010941|GO:0034446|GO:0007275|GO:0060627|GO:0048513|GO:0043168|GO:0032940|GO:0001882|GO:0016772|GO:0051128|GO:0045807|GO:0005887|GO:0048608|GO:0004888|GO:0005737|GO:0007267|GO:0009611|GO:0007423|GO:0006928|GO:0001775|GO:0031589|GO:0007548|GO:0072372|GO:0060548|GO:0031226|GO:0046649|GO:0050865|GO:0007154|GO:0001750|GO:0007276|GO:0016477|GO:0007165|GO:0008219|GO:0002695|GO:0000166|GO:0048869|GO:0016021|GO:0048806|GO:0019538|GO:0050878|GO:0016192|GO:0051249|GO:0000902|GO:0006909|GO:0030540|GO:0030168|GO:0030101|GO:0048232|GO:0007166|GO:0001654|GO:0035639|GO:0043412|GO:0061458|GO:0030097|GO:0030098|GO:0043069|GO:0007596|GO:0001883|GO:0000904|GO:0036211|GO:0042060|GO:0032549|GO:0051250|GO:0007599|GO:0030100|GO:0050766|GO:0016301|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0046903|GO:0017076|GO:0030154|GO:0016773|GO:0043067|GO:0031513|GO:0060068|GO:0002521|GO:0043491|GO:0007283|GO:0050764|GO:0043010|GO:0005524|GO:0030554|GO:0016310|GO:0001779|GO:0042981|GO:0043066|GO:0004672|GO:0043277|GO:0006897|GO:0004714|GO:0006464|GO:0006915|GO:2000107|GO:0006468|GO:0004713|GO:0018193|GO:0018108 locomotion|developmental process|signal transducer activity|reproduction|immune system process|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|negative regulation of immune system process|organic cyclic compound binding|receptor activity|negative regulation of cellular process|regulation of cellular process|leukocyte activation|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|leukocyte migration|ion binding|sexual reproduction|cellular metabolic process|signaling receptor activity|developmental process involved in reproduction|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|multicellular organism reproduction|intrinsic component of membrane|extracellular space|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|transferase activity|anatomical structure development|cilium|multicellular organismal reproductive process|coagulation|retina development in camera-type eye|cell development|transport|positive regulation of cellular component organization|rhabdomere|regulation of cell death|substrate adhesion-dependent cell spreading|multicellular organism development|regulation of vesicle-mediated transport|animal organ development|anion binding|secretion by cell|nucleoside binding|transferase activity, transferring phosphorus-containing groups|regulation of cellular component organization|positive regulation of endocytosis|integral component of plasma membrane|reproductive structure development|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|response to wounding|sensory organ development|movement of cell or subcellular component|cell activation|cell-substrate adhesion|sex differentiation|primary cilium|negative regulation of cell death|intrinsic component of plasma membrane|lymphocyte activation|regulation of cell activation|cell communication|photoreceptor outer segment|gamete generation|cell migration|signal transduction|cell death|negative regulation of leukocyte activation|nucleotide binding|cellular developmental process|integral component of membrane|genitalia development|protein metabolic process|regulation of body fluid levels|vesicle-mediated transport|regulation of lymphocyte activation|cell morphogenesis|phagocytosis|female genitalia development|platelet activation|natural killer cell activation|male gamete generation|cell surface receptor signaling pathway|eye development|purine ribonucleoside triphosphate binding|macromolecule modification|reproductive system development|hemopoiesis|lymphocyte differentiation|negative regulation of programmed cell death|blood coagulation|purine nucleoside binding|cell morphogenesis involved in differentiation|protein modification process|wound healing|ribonucleoside binding|negative regulation of lymphocyte activation|hemostasis|regulation of endocytosis|positive regulation of phagocytosis|kinase activity|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|secretion|purine nucleotide binding|cell differentiation|phosphotransferase activity, alcohol group as acceptor|regulation of programmed cell death|nonmotile primary cilium|vagina development|leukocyte differentiation|protein kinase B signaling|spermatogenesis|regulation of phagocytosis|camera-type eye development|ATP binding|adenyl nucleotide binding|phosphorylation|natural killer cell differentiation|regulation of apoptotic process|negative regulation of apoptotic process|protein kinase activity|apoptotic cell clearance|endocytosis|transmembrane receptor protein tyrosine kinase activity|cellular protein modification process|apoptotic process|negative regulation of leukocyte apoptotic process|protein phosphorylation|protein tyrosine kinase activity|peptidyl-amino acid modification|peptidyl-tyrosine phosphorylation - - - - 2:111898479-112029561 2 10 22 53 32 57 0.0153868964429334 0.0699231042843914 0.152605002781592 0.365356646817943 0.202002347597804 0.411005123317679 0.0793050011696389 0.326121372577809 -2.03992523831892 0.000152811402866658 0.00115465239716052 DOWN ENSG00000150076 CCDC7 coiled-coil domain containing 7 [Source:HGNC Symbol;Acc:HGNC:26533] - - - - - - 10:32567723-32882874 0 2 1 11 4 20 0 0.0323620951820133 0.0160444696249294 0.175473777893068 0.0584285596877783 0.333716572125639 0.0161355216023142 0.189206303235495 -3.55164803081004 0.000152912790654349 0.00115512612656754 DOWN ENSG00000263931 RP11-180P8.1 - - - - - - - 17:62935402-62966810 3 2 6 19 12 26 0.426172327949687 0.25818193606052 0.768410265020645 2.41808060326072 1.39853037001519 3.46112636560618 0.484254843010284 2.42591244629403 -2.32468910069221 0.000153118852420784 0.00115639013917786 DOWN ENSG00000196787 HIST1H2AG histone cluster 1, H2ag [Source:HGNC Symbol;Acc:HGNC:4737] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031982|GO:0046483|GO:0043231|GO:0019899|GO:0046983|GO:0009890|GO:0016458|GO:0006139|GO:0000790|GO:0070062|GO:0044249|GO:0000786|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0046982|GO:0051252|GO:0006325|GO:0031981|GO:0005694|GO:0000228|GO:0006342|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045814|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0040029|GO:0006351|GO:0006355|GO:1903507|GO:1903506 macromolecular complex|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|protein dimerization activity|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|nuclear chromatin|extracellular exosome|cellular biosynthetic process|nucleosome|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|chromatin organization|nuclear lumen|chromosome|nuclear chromosome|chromatin silencing|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of gene expression, epigenetic|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription K11251 histone H2A[-] hsa05034|hsa05322 Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 6:27133042-27135291 14 26 21 69 58 47 0.440149396543648 0.74287549069147 0.595246985668496 1.9436082374851 1.49609518496405 1.38482361478007 0.592757290967871 1.60817567907641 -1.43991160868752 0.000154077429073557 0.00116168403738572 DOWN ENSG00000230109 RP11-275N1.1 - - - - - - - 10:21340233-21372950 0 0 1 7 5 8 0 0 0.145204277493951 1.0105556016898 0.661047597320947 1.20810132066548 0.048401425831317 0.959901506558742 -4.30976492876612 0.000153991198894651 0.00116168403738572 DOWN ENSG00000232224 LINC00202-1 long intergenic non-protein coding RNA 202-1 [Source:HGNC Symbol;Acc:HGNC:24672] - - - - - - 10:26931206-26942001 3 5 4 13 17 33 0.0403947124702977 0.0611851798730905 0.0485558066210229 0.156817477118924 0.187793684714781 0.41638973438643 0.050045232988137 0.253666965406712 -2.34163109389879 0.000154016307524902 0.00116168403738572 DOWN ENSG00000165861 ZFYVE1 zinc finger, FYVE domain containing 1 [Source:HGNC Symbol;Acc:HGNC:13180] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0019898|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0044232|GO:0043227|GO:0008289|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0043168|GO:0005543|GO:0043231|GO:0043169|GO:1990462|GO:0005737|GO:0044092|GO:0005783|GO:0044233|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0005794|GO:0032268|GO:0046872|GO:0043412|GO:0097629|GO:0035091|GO:0005773|GO:0036211|GO:0032269|GO:0048471|GO:0051346|GO:0006796|GO:0005795|GO:0044267|GO:0051174|GO:0051246|GO:0000407|GO:0010923|GO:0016311|GO:0005545|GO:0005776|GO:1901981|GO:0046914|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:1902936|GO:0005547|GO:0035305|GO:0008270|GO:0035303|GO:0035308|GO:0043325 cell|membrane|cellular process|metabolic process|binding|extrinsic component of membrane|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|organelle membrane contact site|membrane-bounded organelle|lipid binding|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|anion binding|phospholipid binding|intracellular membrane-bounded organelle|cation binding|omegasome|cytoplasm|negative regulation of molecular function|endoplasmic reticulum|ER-mitochondrion membrane contact site|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of cellular protein metabolic process|metal ion binding|macromolecule modification|extrinsic component of omegasome membrane|phosphatidylinositol binding|vacuole|protein modification process|negative regulation of cellular protein metabolic process|perinuclear region of cytoplasm|negative regulation of hydrolase activity|phosphate-containing compound metabolic process|Golgi stack|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|pre-autophagosomal structure|negative regulation of phosphatase activity|dephosphorylation|1-phosphatidylinositol binding|autophagosome|phosphatidylinositol phosphate binding|transition metal ion binding|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|phosphatidylinositol bisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|negative regulation of dephosphorylation|zinc ion binding|regulation of dephosphorylation|negative regulation of protein dephosphorylation|phosphatidylinositol-3,4-bisphosphate binding - - - - 14:72969451-73027212 149 181 265 409 362 505 1.33044658374064 1.46882505692621 2.13339433411131 3.27214126739874 2.65208551566549 4.2260202500343 1.64422199159272 3.38341567769951 -1.04107533882829 0.000155638090385893 0.00117156317457903 DOWN ENSG00000182687 GALR2 galanin receptor 2 [Source:HGNC Symbol;Acc:HGNC:4133] GO:0032502|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0007631|GO:0033218|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0042562|GO:0006807|GO:0051050|GO:0071704|GO:0044237|GO:0038023|GO:0016043|GO:0044708|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0044255|GO:0042277|GO:0017046|GO:0006725|GO:0048468|GO:0006810|GO:1901360|GO:0007275|GO:0043647|GO:0050877|GO:0034641|GO:0044281|GO:0043270|GO:0019637|GO:0031325|GO:0046483|GO:0005887|GO:0004888|GO:0005737|GO:0003012|GO:0007267|GO:0042592|GO:0009890|GO:0019725|GO:0006139|GO:0031226|GO:0055086|GO:0007154|GO:0044092|GO:0055085|GO:0006629|GO:0007165|GO:0007586|GO:0007611|GO:0050790|GO:0071804|GO:0030030|GO:0043086|GO:0048869|GO:0016021|GO:0044249|GO:0031324|GO:0031323|GO:0032411|GO:0005829|GO:0031175|GO:0007186|GO:0010468|GO:0006936|GO:0034645|GO:0046486|GO:0007166|GO:0051350|GO:0019693|GO:0042923|GO:0048878|GO:0051252|GO:0006066|GO:0010628|GO:0031279|GO:0034767|GO:0006811|GO:0055082|GO:0034765|GO:0043269|GO:0043268|GO:0006796|GO:1901137|GO:0051174|GO:0010467|GO:0007399|GO:0050890|GO:0032414|GO:0031328|GO:0071805|GO:0009059|GO:0030154|GO:0008528|GO:0016070|GO:0004930|GO:0010557|GO:0006644|GO:0022898|GO:0034220|GO:0048666|GO:0030182|GO:0045893|GO:0098655|GO:0007200|GO:0007187|GO:1901379|GO:0009259|GO:0009117|GO:0032774|GO:0046390|GO:0006812|GO:0045980|GO:2001141|GO:0007194|GO:0032412|GO:0045761|GO:2001259|GO:0008188|GO:0006163|GO:0050801|GO:0007218|GO:0022008|GO:0009165|GO:1901381|GO:0006351|GO:0006650|GO:0006355|GO:0006873|GO:1901018|GO:0045944|GO:0006366|GO:1901016|GO:0006164|GO:0007188|GO:0046488|GO:1902608|GO:0006357|GO:0043266|GO:0048699|GO:1903506|GO:0009187|GO:0030001|GO:2001257|GO:0004966|GO:0030003|GO:0015672|GO:0030802|GO:0007268|GO:0009190|GO:0030818|GO:0006813|GO:0046058|GO:0007189|GO:0055065|GO:0009152|GO:0030817|GO:0052652|GO:0006875|GO:0030814|GO:0030815|GO:0006171|GO:0006874|GO:0055074|GO:0051480|GO:0007204 developmental process|signal transducer activity|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|feeding behavior|amide binding|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|hormone binding|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|cellular metabolic process|signaling receptor activity|cellular component organization|single-organism behavior|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|cellular lipid metabolic process|peptide binding|peptide hormone binding|cellular aromatic compound metabolic process|cell development|transport|organic cyclic compound metabolic process|multicellular organism development|inositol phosphate metabolic process|neurological system process|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of ion transport|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|integral component of plasma membrane|transmembrane signaling receptor activity|cytoplasm|muscle system process|cell-cell signaling|homeostatic process|negative regulation of biosynthetic process|cellular homeostasis|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|nucleobase-containing small molecule metabolic process|cell communication|negative regulation of molecular function|transmembrane transport|lipid metabolic process|signal transduction|digestion|learning or memory|regulation of catalytic activity|cellular potassium ion transport|cell projection organization|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of transporter activity|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|glycerolipid metabolic process|cell surface receptor signaling pathway|negative regulation of lyase activity|ribose phosphate metabolic process|neuropeptide binding|chemical homeostasis|regulation of RNA metabolic process|alcohol metabolic process|positive regulation of gene expression|regulation of cyclase activity|positive regulation of ion transmembrane transport|ion transport|cellular chemical homeostasis|regulation of ion transmembrane transport|regulation of ion transport|positive regulation of potassium ion transport|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|gene expression|nervous system development|cognition|positive regulation of ion transmembrane transporter activity|positive regulation of cellular biosynthetic process|potassium ion transmembrane transport|macromolecule biosynthetic process|cell differentiation|G-protein coupled peptide receptor activity|RNA metabolic process|G-protein coupled receptor activity|positive regulation of macromolecule biosynthetic process|phospholipid metabolic process|regulation of transmembrane transporter activity|ion transmembrane transport|neuron development|neuron differentiation|positive regulation of transcription, DNA-templated|cation transmembrane transport|phospholipase C-activating G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|regulation of potassium ion transmembrane transport|ribonucleotide metabolic process|nucleotide metabolic process|RNA biosynthetic process|ribose phosphate biosynthetic process|cation transport|negative regulation of nucleotide metabolic process|regulation of RNA biosynthetic process|negative regulation of adenylate cyclase activity|regulation of ion transmembrane transporter activity|regulation of adenylate cyclase activity|positive regulation of cation channel activity|neuropeptide receptor activity|purine nucleotide metabolic process|ion homeostasis|neuropeptide signaling pathway|neurogenesis|nucleotide biosynthetic process|positive regulation of potassium ion transmembrane transport|transcription, DNA-templated|glycerophospholipid metabolic process|regulation of transcription, DNA-templated|cellular ion homeostasis|positive regulation of potassium ion transmembrane transporter activity|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of potassium ion transmembrane transporter activity|purine nucleotide biosynthetic process|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|phosphatidylinositol metabolic process|positive regulation of large conductance calcium-activated potassium channel activity|regulation of transcription from RNA polymerase II promoter|regulation of potassium ion transport|generation of neurons|regulation of nucleic acid-templated transcription|cyclic nucleotide metabolic process|metal ion transport|regulation of cation channel activity|galanin receptor activity|cellular cation homeostasis|monovalent inorganic cation transport|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|cyclic nucleotide biosynthetic process|negative regulation of cAMP biosynthetic process|potassium ion transport|cAMP metabolic process|adenylate cyclase-activating G-protein coupled receptor signaling pathway|metal ion homeostasis|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|cellular metal ion homeostasis|regulation of cAMP metabolic process|negative regulation of cAMP metabolic process|cAMP biosynthetic process|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04231 galanin receptor 2[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 17:76074794-76077541 17 11 12 3 5 1 0.881600953514116 0.518468289976271 0.561097231642641 0.139377198471027 0.212756521425144 0.0485965875203212 0.653722158377676 0.133576769138831 2.29100847431879 0.00015601004117107 0.00117347537644775 UP ENSG00000267105 CTD-2369P2.4 - - - - - - - 19:10259109-10260045 7 9 8 1 1 1 1.3948396369341 1.62990462920985 1.43725187598228 0.17844730563609 0.163558387561556 0.186720409514699 1.48733204737541 0.176242034237448 3.0770968081259 0.000156601399060416 0.0011764414110593 UP ENSG00000109339 MAPK10 mitogen-activated protein kinase 10 [Source:HGNC Symbol;Acc:HGNC:6872] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0042752|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0005057|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0016740|GO:0019222|GO:0002757|GO:0045087|GO:0004708|GO:0006725|GO:0009314|GO:1901360|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0002218|GO:0009966|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0004702|GO:0050790|GO:0000166|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031323|GO:0051090|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0007166|GO:0035639|GO:0043412|GO:0002758|GO:0051252|GO:0001883|GO:0051347|GO:0036211|GO:0032549|GO:0004707|GO:0031981|GO:0031098|GO:0051247|GO:0005654|GO:0005739|GO:0002764|GO:0016301|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0017076|GO:0051246|GO:0009059|GO:1902531|GO:0016070|GO:0016773|GO:0005634|GO:0009416|GO:0045089|GO:0045088|GO:0031401|GO:0043408|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0016310|GO:0002768|GO:0002221|GO:0043410|GO:0004672|GO:0006464|GO:0051403|GO:0043549|GO:0006351|GO:0006355|GO:0033674|GO:0045859|GO:0045860|GO:0002224|GO:0043406|GO:0006468|GO:0004705|GO:0004712|GO:1903506|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0038093|GO:0004674|GO:0001934|GO:0042327|GO:0034166|GO:0034134|GO:0038124|GO:0000187|GO:0038095|GO:0002756|GO:0071902|GO:0034138|GO:0002755|GO:0034146|GO:0071900|GO:0034142|GO:0038123|GO:0034162|GO:0032147|GO:0035666 signal transducer activity|immune system process|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|regulation of circadian rhythm|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|receptor signaling protein activity|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|transferase activity|regulation of metabolic process|immune response-activating signal transduction|innate immune response|MAP kinase kinase activity|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|activation of innate immune response|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|receptor signaling protein serine/threonine kinase activity|regulation of catalytic activity|nucleotide binding|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|macromolecule modification|innate immune response-activating signal transduction|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of transferase activity|protein modification process|ribonucleoside binding|MAP kinase activity|nuclear lumen|stress-activated protein kinase signaling cascade|positive regulation of protein metabolic process|nucleoplasm|mitochondrion|immune response-regulating signaling pathway|kinase activity|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|phosphotransferase activity, alcohol group as acceptor|nucleus|response to light stimulus|positive regulation of innate immune response|regulation of innate immune response|positive regulation of protein modification process|regulation of MAPK cascade|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|immune response-regulating cell surface receptor signaling pathway|pattern recognition receptor signaling pathway|positive regulation of MAPK cascade|protein kinase activity|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|protein phosphorylation|JUN kinase activity|protein serine/threonine/tyrosine kinase activity|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|Fc receptor signaling pathway|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|positive regulation of phosphorylation|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|activation of MAPK activity|Fc-epsilon receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|regulation of protein serine/threonine kinase activity|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|activation of protein kinase activity|TRIF-dependent toll-like receptor signaling pathway K04440 c-Jun N-terminal kinase[2.7.11.24] hsa05200|hsa04010|hsa04014|hsa04510|hsa05169|hsa04024|hsa05168|hsa05152|hsa05164|hsa04141|hsa04932|hsa05161|hsa04310|hsa04210|hsa04910|hsa04068|hsa05160|hsa04380|hsa04728|hsa04722|hsa04071|hsa05145|hsa04668|hsa04931|hsa04620|hsa05142|hsa05231|hsa04933|hsa04723|hsa04750|hsa04914|hsa04912|hsa04012|hsa05132|hsa05133|hsa04917|hsa04920|hsa04622|hsa05120|hsa04664|hsa05212|hsa05131|hsa05210|hsa04621|hsa04930 Pathways in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Protein processing in endoplasmic reticulum - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|RIG-I-like receptor signaling pathway - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Shigellosis - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|NOD-like receptor signaling pathway - Homo sapiens (human)|Type II diabetes mellitus - Homo sapiens (human) 4:86015123-86594131 1 4 0 7 14 26 0.00353886550095584 0.0128593893242125 0 0.0221850232105726 0.040632917842043 0.0861949757499563 0.00546608494172278 0.049670972267524 -3.18382320229175 0.000157076692042472 0.00117971511049961 DOWN ENSG00000280693 SH3PXD2A-AS1 SH3PXD2A antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:45242] - - - - - - 10:103745966-103755423 69 73 60 170 168 136 1.65228427784175 1.5886944740792 1.29540161525019 3.64737990314476 3.30075744652946 3.05212919410159 1.51212678905705 3.3334221812586 -1.14042493582902 0.000158260565369896 0.00118800878012393 DOWN ENSG00000229816 DDX50P1 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 50 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:18974] - - - - - - 2:32201600-32203999 26 21 30 10 12 5 0.766307874000496 0.562526570132637 0.797197838144862 0.264086885861811 0.290195051778151 0.13812468484958 0.708677427425998 0.230802207496514 1.61847207485669 0.000160114243829607 0.0012013195866522 UP ENSG00000224763 FDPSP8 farnesyl diphosphate synthase pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:39085] - - - - - - 1:211660189-211661277 15 15 12 1 3 6 0.974321923504981 0.885527966798817 0.702788451754419 0.058171527548955 0.159900423695247 0.365275472007998 0.854212780686072 0.194449141084067 2.13520262151844 0.000160352467527022 0.00120280466471149 UP ENSG00000112425 EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) [Source:HGNC Symbol;Acc:HGNC:3413] GO:0032502|GO:0032991|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0030246|GO:0043227|GO:0044708|GO:0071944|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0044262|GO:0010506|GO:0009991|GO:0007275|GO:0050877|GO:0015980|GO:0016788|GO:0044281|GO:0031325|GO:0033554|GO:0043231|GO:0005737|GO:0010508|GO:0030529|GO:0005975|GO:0010646|GO:0007154|GO:0005783|GO:0030247|GO:0007611|GO:0016236|GO:0006091|GO:0044249|GO:0019538|GO:0031323|GO:0055114|GO:0005829|GO:0005976|GO:0034645|GO:0043412|GO:0007612|GO:2001070|GO:0036211|GO:0016239|GO:0016241|GO:0033692|GO:0005844|GO:0005977|GO:0005996|GO:0006112|GO:0006796|GO:0044267|GO:0007399|GO:0050890|GO:0009059|GO:0031667|GO:0005634|GO:0016051|GO:0042578|GO:0005978|GO:0046958|GO:0019318|GO:0016311|GO:0000271|GO:0016791|GO:0006464|GO:0006470|GO:0019203|GO:0006006|GO:0004721|GO:0046959|GO:0035335|GO:0004722|GO:0008138|GO:0004725 developmental process|macromolecular complex|behavior|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|carbohydrate binding|membrane-bounded organelle|single-organism behavior|cell periphery|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|cellular carbohydrate metabolic process|regulation of autophagy|response to extracellular stimulus|multicellular organism development|neurological system process|energy derivation by oxidation of organic compounds|hydrolase activity, acting on ester bonds|small molecule metabolic process|positive regulation of cellular metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|positive regulation of autophagy|intracellular ribonucleoprotein complex|carbohydrate metabolic process|regulation of cell communication|cell communication|endoplasmic reticulum|polysaccharide binding|learning or memory|macroautophagy|generation of precursor metabolites and energy|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|oxidation-reduction process|cytosol|polysaccharide metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|learning|starch binding|protein modification process|positive regulation of macroautophagy|regulation of macroautophagy|cellular polysaccharide biosynthetic process|polysome|glycogen metabolic process|monosaccharide metabolic process|energy reserve metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|nervous system development|cognition|macromolecule biosynthetic process|response to nutrient levels|nucleus|carbohydrate biosynthetic process|phosphoric ester hydrolase activity|glycogen biosynthetic process|nonassociative learning|hexose metabolic process|dephosphorylation|polysaccharide biosynthetic process|phosphatase activity|cellular protein modification process|protein dephosphorylation|carbohydrate phosphatase activity|glucose metabolic process|phosphoprotein phosphatase activity|habituation|peptidyl-tyrosine dephosphorylation|protein serine/threonine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity - - - - 6:145501583-145736024 15 7 17 47 41 36 0.10115707643216 0.0429060481658267 0.103364811685314 0.283993125674818 0.226861106557122 0.22753064168171 0.0824759787611002 0.24612829130455 -1.57736459963258 0.000160673934230423 0.00120461065608112 DOWN ENSG00000250264 XXbac-BPG246D15.9 - GO:0032991|GO:0005215|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0019882|GO:0043229|GO:0042175|GO:0043167|GO:0006955|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019884|GO:0006810|GO:0098797|GO:0015197|GO:0005102|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0031227|GO:0005737|GO:0042824|GO:0022891|GO:0030176|GO:0055085|GO:0005783|GO:0002504|GO:0019883|GO:0048002|GO:0000166|GO:0016021|GO:0031301|GO:0042825|GO:0016820|GO:0035639|GO:0001883|GO:0016818|GO:0042886|GO:0032549|GO:0042287|GO:0002474|GO:0017076|GO:0002476|GO:0002591|GO:0042613|GO:0005524|GO:0030554|GO:0015833|GO:0019885|GO:0042626|GO:0015440|GO:0016462|GO:0017111|GO:0002481|GO:0016887|GO:0002485|GO:0002489|GO:0042623|GO:0043492 macromolecular complex|transporter activity|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|antigen processing and presentation|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|immune response|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|antigen processing and presentation of exogenous antigen|transport|plasma membrane protein complex|peptide transporter activity|receptor binding|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|intrinsic component of endoplasmic reticulum membrane|cytoplasm|MHC class I peptide loading complex|substrate-specific transmembrane transporter activity|integral component of endoplasmic reticulum membrane|transmembrane transport|endoplasmic reticulum|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|antigen processing and presentation of endogenous antigen|antigen processing and presentation of peptide antigen|nucleotide binding|integral component of membrane|integral component of organelle membrane|TAP complex|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|amide transport|ribonucleoside binding|MHC protein binding|antigen processing and presentation of peptide antigen via MHC class I|purine nucleotide binding|antigen processing and presentation of endogenous peptide antigen via MHC class Ib|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|MHC class II protein complex|ATP binding|adenyl nucleotide binding|peptide transport|antigen processing and presentation of endogenous peptide antigen via MHC class I|ATPase activity, coupled to transmembrane movement of substances|peptide-transporting ATPase activity|pyrophosphatase activity|nucleoside-triphosphatase activity|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|ATPase activity|antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|ATPase activity, coupled|ATPase activity, coupled to movement of substances - - - - 6:32813767-32838822 0 0 0 39 0 5 0 0 0 0.913773410110346 0 0.122550552177077 0 0.345441320762474 -Inf 0.000162865410063021 0.00121920359880176 DOWN ENSG00000110900 TSPAN11 tetraspanin 11 [Source:HGNC Symbol;Acc:HGNC:30795] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0071944|GO:0031224|GO:0005886|GO:0005887|GO:0031226|GO:0007154|GO:0007165|GO:0016021|GO:0007166 signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|cell periphery|intrinsic component of membrane|plasma membrane|integral component of plasma membrane|intrinsic component of plasma membrane|cell communication|signal transduction|integral component of membrane|cell surface receptor signaling pathway - - - - 12:30926428-30996599 8 6 20 28 38 70 0.0719111073307054 0.0490181487450015 0.162099509459178 0.225517823710678 0.280273568003871 0.58972757789344 0.0943429218449616 0.36517298986933 -1.95259387227258 0.000164003716223846 0.00122680204062809 DOWN ENSG00000068305 MEF2A myocyte enhancer factor 2A [Source:HGNC Symbol;Acc:HGNC:6993] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0051641|GO:0000989|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0002757|GO:0045087|GO:0045595|GO:0003712|GO:0006725|GO:0051640|GO:0009888|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0016358|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0061061|GO:0045597|GO:0043231|GO:0046332|GO:0019899|GO:0005737|GO:0000981|GO:0002218|GO:0001076|GO:0005667|GO:0046983|GO:0009890|GO:0003682|GO:0006139|GO:0050776|GO:0000790|GO:0007154|GO:0007165|GO:0050778|GO:0008134|GO:0008219|GO:0030030|GO:0048869|GO:0030029|GO:0010035|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0003013|GO:0006996|GO:0003713|GO:0000165|GO:0000982|GO:0051646|GO:0000902|GO:0031175|GO:0003677|GO:0051149|GO:0010468|GO:0034645|GO:0007166|GO:0043412|GO:0007010|GO:0002758|GO:0072358|GO:0001104|GO:0061337|GO:0001085|GO:0010629|GO:0007005|GO:0035035|GO:0042692|GO:0046982|GO:0048813|GO:0051252|GO:0035051|GO:0048738|GO:0055006|GO:0000904|GO:0010628|GO:0010038|GO:0051147|GO:0036211|GO:0060537|GO:0003705|GO:0031981|GO:0031098|GO:0042826|GO:0070848|GO:0005654|GO:0005694|GO:0002764|GO:0000228|GO:0055001|GO:0030036|GO:0070925|GO:0019900|GO:0012501|GO:0006796|GO:0035556|GO:0071241|GO:0044267|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0048858|GO:0030239|GO:0001228|GO:0007517|GO:0001191|GO:0016070|GO:0072359|GO:0008015|GO:0033613|GO:0010557|GO:0048311|GO:0005634|GO:0045089|GO:0045088|GO:0048666|GO:0030182|GO:0008016|GO:0000002|GO:0055002|GO:0000975|GO:0045893|GO:0055003|GO:0045892|GO:0055013|GO:0032774|GO:0043565|GO:0060047|GO:0051592|GO:2001141|GO:0001077|GO:0071363|GO:0016310|GO:0038179|GO:1902679|GO:0002221|GO:0003690|GO:0007167|GO:0001105|GO:0051146|GO:0070375|GO:0031032|GO:0019901|GO:0014706|GO:0022008|GO:0048667|GO:0055007|GO:0006464|GO:0048812|GO:0051403|GO:0006351|GO:0006915|GO:0006355|GO:0071248|GO:0048011|GO:0045944|GO:0006366|GO:1903507|GO:0002224|GO:0006357|GO:0055005|GO:0006468|GO:0048699|GO:0071277|GO:1903506|GO:0044212|GO:0055015|GO:0001190|GO:0055012|GO:0000122|GO:0007169|GO:0034166|GO:0034134|GO:0038124|GO:0000976|GO:0001012|GO:0002756|GO:0034138|GO:0002755|GO:0034146|GO:0001159|GO:0034142|GO:0038123|GO:0034162|GO:0000977|GO:0000987|GO:0035666|GO:0000978 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|cellular localization|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|immune response-activating signal transduction|innate immune response|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|organelle localization|tissue development|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|dendrite development|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|SMAD binding|enzyme binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|activation of innate immune response|transcription factor activity, RNA polymerase II transcription factor binding|transcription factor complex|protein dimerization activity|negative regulation of biosynthetic process|chromatin binding|nucleobase-containing compound metabolic process|regulation of immune response|nuclear chromatin|cell communication|signal transduction|positive regulation of immune response|transcription factor binding|cell death|cell projection organization|cellular developmental process|actin filament-based process|response to inorganic substance|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|organelle organization|transcription coactivator activity|MAPK cascade|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|mitochondrion localization|cell morphogenesis|neuron projection development|DNA binding|positive regulation of muscle cell differentiation|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|macromolecule modification|cytoskeleton organization|innate immune response-activating signal transduction|cardiovascular system development|RNA polymerase II transcription cofactor activity|cardiac conduction|RNA polymerase II transcription factor binding|negative regulation of gene expression|mitochondrion organization|histone acetyltransferase binding|muscle cell differentiation|protein heterodimerization activity|dendrite morphogenesis|regulation of RNA metabolic process|cardiocyte differentiation|cardiac muscle tissue development|cardiac cell development|cell morphogenesis involved in differentiation|positive regulation of gene expression|response to metal ion|regulation of muscle cell differentiation|protein modification process|muscle tissue development|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|nuclear lumen|stress-activated protein kinase signaling cascade|histone deacetylase binding|response to growth factor|nucleoplasm|chromosome|immune response-regulating signaling pathway|nuclear chromosome|muscle cell development|actin cytoskeleton organization|organelle assembly|kinase binding|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular response to inorganic substance|cellular protein metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|myofibril assembly|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|muscle organ development|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|circulatory system development|blood circulation|activating transcription factor binding|positive regulation of macromolecule biosynthetic process|mitochondrion distribution|nucleus|positive regulation of innate immune response|regulation of innate immune response|neuron development|neuron differentiation|regulation of heart contraction|mitochondrial genome maintenance|striated muscle cell development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|cardiac myofibril assembly|negative regulation of transcription, DNA-templated|cardiac muscle cell development|RNA biosynthetic process|sequence-specific DNA binding|heart contraction|response to calcium ion|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cellular response to growth factor stimulus|phosphorylation|neurotrophin signaling pathway|negative regulation of RNA biosynthetic process|pattern recognition receptor signaling pathway|double-stranded DNA binding|enzyme linked receptor protein signaling pathway|RNA polymerase II transcription coactivator activity|striated muscle cell differentiation|ERK5 cascade|actomyosin structure organization|protein kinase binding|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|cardiac muscle cell differentiation|cellular protein modification process|neuron projection morphogenesis|stress-activated MAPK cascade|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular response to metal ion|neurotrophin TRK receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|toll-like receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|ventricular cardiac myofibril assembly|protein phosphorylation|generation of neurons|cellular response to calcium ion|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|ventricular cardiac muscle cell development|transcriptional activator activity, RNA polymerase II transcription factor binding|ventricular cardiac muscle cell differentiation|negative regulation of transcription from RNA polymerase II promoter|transmembrane receptor protein tyrosine kinase signaling pathway|toll-like receptor 10 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|toll-like receptor 5 signaling pathway|core promoter proximal region DNA binding|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|toll-like receptor 9 signaling pathway|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|TRIF-dependent toll-like receptor signaling pathway|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09260 MADS-box transcription enhancer factor 2A[-] hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) 15:99565417-99716466 133 221 308 434 458 564 0.39339304069721 0.594084222627314 0.821371776214002 1.15017321247743 1.11149940739676 1.56344909116914 0.602949679846175 1.27504057034778 -1.08043364295518 0.000165377369886521 0.00123583879864636 DOWN ENSG00000226268 RP11-61N20.3 - - - - - - - 11:49433480-49434438 96 104 80 46 56 36 7.08107752634863 6.97171993349659 5.32024052453556 3.04003230812336 3.38909888670421 2.48860156475439 6.45767932812693 2.97257758652732 1.11930133628108 0.000165692693190971 0.00123788530093175 UP ENSG00000197815 RP1-253P7.4 - - - - - - - 17:17858227-17860041 8 4 10 25 22 37 0.311773280212298 0.141680004581971 0.351394225877209 0.872996835297435 0.703508492956118 1.35143506665409 0.268282503557159 0.975980131635881 -1.86309880848501 0.000166602580598217 0.00124437163902406 DOWN ENSG00000163485 ADORA1 adenosine A1 receptor [Source:HGNC Symbol;Acc:HGNC:262] GO:0040011|GO:0032502|GO:0004871|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0042752|GO:0051716|GO:0040013|GO:0042995|GO:0002683|GO:0097159|GO:0004872|GO:0009892|GO:0048786|GO:0048523|GO:0048521|GO:0051606|GO:0044877|GO:0008283|GO:0007622|GO:0050794|GO:0060076|GO:0040012|GO:0043229|GO:0051050|GO:0006950|GO:0007623|GO:0071704|GO:0050900|GO:0009056|GO:0009628|GO:1900453|GO:0051051|GO:0044237|GO:0051641|GO:0050795|GO:0038023|GO:0048870|GO:0023051|GO:0044297|GO:0016043|GO:0043227|GO:0044708|GO:0071944|GO:0042754|GO:0009605|GO:0023057|GO:0009893|GO:0031252|GO:0016787|GO:0031224|GO:0032279|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0097060|GO:0019222|GO:0043576|GO:0060341|GO:0042127|GO:0007585|GO:0003014|GO:0050804|GO:0042391|GO:0002685|GO:0043025|GO:0016323|GO:0006810|GO:0043195|GO:0010941|GO:0007275|GO:0070256|GO:0050877|GO:0005102|GO:0016788|GO:0032940|GO:0006952|GO:0001882|GO:0043270|GO:0031325|GO:0030431|GO:0045211|GO:0050806|GO:0009582|GO:0050803|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0003012|GO:0007267|GO:0042734|GO:0009611|GO:0006928|GO:0032900|GO:0032403|GO:0042592|GO:0070255|GO:0043005|GO:0009966|GO:0046983|GO:0045184|GO:0046883|GO:0043197|GO:0036477|GO:0014069|GO:0048871|GO:0060548|GO:0010646|GO:0031226|GO:0043085|GO:0035814|GO:0008104|GO:0050906|GO:0007154|GO:0042321|GO:0061024|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0005783|GO:0032589|GO:0002686|GO:0003016|GO:0051649|GO:0046888|GO:2000021|GO:0044306|GO:0045932|GO:0008219|GO:0051271|GO:0007588|GO:0031256|GO:0008285|GO:0001666|GO:0008217|GO:0051047|GO:0050790|GO:0051048|GO:1903531|GO:0031072|GO:0031253|GO:0050805|GO:0045833|GO:0010817|GO:0016021|GO:2000145|GO:0009967|GO:0009266|GO:0010469|GO:0048512|GO:0019538|GO:0023014|GO:0031323|GO:2000146|GO:0050878|GO:0003013|GO:0043271|GO:0000165|GO:0016192|GO:1902533|GO:0032268|GO:0006909|GO:0007186|GO:0060292|GO:0035150|GO:0006936|GO:0032244|GO:0090150|GO:0048167|GO:0007166|GO:0002793|GO:0003071|GO:0030424|GO:0043412|GO:0097205|GO:0007176|GO:0044309|GO:0007589|GO:0050727|GO:0016042|GO:0032229|GO:0043069|GO:0046982|GO:0048878|GO:0002087|GO:0045187|GO:0001659|GO:0060078|GO:0001883|GO:0015031|GO:0035813|GO:0044062|GO:0090257|GO:0045988|GO:0032795|GO:0030334|GO:0050994|GO:0014050|GO:0051347|GO:0031683|GO:0036211|GO:0046907|GO:0042886|GO:0006811|GO:0006954|GO:0044304|GO:0043679|GO:0007600|GO:0051046|GO:0016048|GO:0072657|GO:0051967|GO:1901184|GO:0042323|GO:0045776|GO:0050728|GO:0045777|GO:0051966|GO:0030425|GO:0050995|GO:0031644|GO:0009914|GO:0030673|GO:0070254|GO:0051247|GO:0001664|GO:0050961|GO:0043269|GO:0030336|GO:0034613|GO:0043268|GO:0032270|GO:0045822|GO:0012501|GO:0016298|GO:0044065|GO:0006796|GO:0035556|GO:0090075|GO:0044267|GO:0051174|GO:0042748|GO:0007399|GO:0019216|GO:0046903|GO:0050890|GO:0051246|GO:0045986|GO:1901264|GO:0042745|GO:1902531|GO:0008015|GO:0014047|GO:0004930|GO:1901186|GO:0042578|GO:0043067|GO:0032228|GO:0045908|GO:0003073|GO:0015837|GO:0097190|GO:2000273|GO:0022410|GO:0006941|GO:0008016|GO:0002790|GO:0004620|GO:0015858|GO:0003093|GO:0016311|GO:0006820|GO:0015711|GO:0014048|GO:0002673|GO:0050951|GO:0031401|GO:0007187|GO:0045742|GO:0006939|GO:0042312|GO:0019233|GO:0008081|GO:0001609|GO:0006937|GO:0043408|GO:0042058|GO:0060047|GO:0006812|GO:0016310|GO:0002526|GO:0015833|GO:0045741|GO:0006605|GO:0046942|GO:0006886|GO:0007167|GO:0045188|GO:0055118|GO:0043410|GO:0042981|GO:0044070|GO:0050965|GO:0050801|GO:0043066|GO:0006865|GO:1900452|GO:0060079|GO:0006897|GO:0044557|GO:0006464|GO:0003094|GO:0006612|GO:0060087|GO:0046717|GO:0046879|GO:0043549|GO:0006915|GO:0050880|GO:0002674|GO:0033674|GO:0006470|GO:0035304|GO:0000186|GO:0004629|GO:0045859|GO:0045860|GO:0007188|GO:0006940|GO:0051930|GO:0043266|GO:0006468|GO:0006835|GO:0035307|GO:0006942|GO:0042311|GO:0043405|GO:0060048|GO:0042325|GO:0001932|GO:0018193|GO:0055117|GO:0030001|GO:0001934|GO:0035306|GO:0001973|GO:0015672|GO:0042327|GO:0035303|GO:0007268|GO:0007169|GO:0050731|GO:0007193|GO:0006813|GO:0050730|GO:0061097|GO:0007270|GO:0055065|GO:0071900|GO:0061098|GO:0032147|GO:0038127|GO:0018108|GO:0007173|GO:0051932|GO:0035249|GO:0055078 locomotion|developmental process|signal transducer activity|immune system process|synapse|behavior|signaling|cell|rhythmic process|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|regulation of circadian rhythm|cellular response to stimulus|negative regulation of locomotion|cell projection|negative regulation of immune system process|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|presynaptic active zone|negative regulation of cellular process|negative regulation of behavior|detection of stimulus|macromolecular complex binding|cell proliferation|rhythmic behavior|regulation of cellular process|excitatory synapse|regulation of locomotion|intracellular organelle|positive regulation of transport|response to stress|circadian rhythm|organic substance metabolic process|leukocyte migration|catabolic process|response to abiotic stimulus|negative regulation of long term synaptic depression|negative regulation of transport|cellular metabolic process|cellular localization|regulation of behavior|signaling receptor activity|cell motility|regulation of signaling|cell body|cellular component organization|membrane-bounded organelle|single-organism behavior|cell periphery|negative regulation of circadian rhythm|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|hydrolase activity|intrinsic component of membrane|asymmetric synapse|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|anatomical structure development|synaptic membrane|regulation of metabolic process|regulation of respiratory gaseous exchange|regulation of cellular localization|regulation of cell proliferation|respiratory gaseous exchange|renal system process|modulation of synaptic transmission|regulation of membrane potential|regulation of leukocyte migration|neuronal cell body|basolateral plasma membrane|transport|terminal bouton|regulation of cell death|multicellular organism development|negative regulation of mucus secretion|neurological system process|receptor binding|hydrolase activity, acting on ester bonds|secretion by cell|defense response|nucleoside binding|positive regulation of ion transport|positive regulation of cellular metabolic process|sleep|postsynaptic membrane|positive regulation of synaptic transmission|detection of abiotic stimulus|regulation of synapse structure or activity|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|muscle system process|cell-cell signaling|presynaptic membrane|response to wounding|movement of cell or subcellular component|negative regulation of neurotrophin production|protein complex binding|homeostatic process|regulation of mucus secretion|neuron projection|regulation of signal transduction|protein dimerization activity|establishment of protein localization|regulation of hormone secretion|dendritic spine|somatodendritic compartment|postsynaptic density|multicellular organismal homeostasis|negative regulation of cell death|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|negative regulation of renal sodium excretion|protein localization|detection of stimulus involved in sensory perception|cell communication|negative regulation of circadian sleep/wake cycle, sleep|membrane organization|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|endoplasmic reticulum|neuron projection membrane|negative regulation of leukocyte migration|respiratory system process|establishment of localization in cell|negative regulation of hormone secretion|regulation of ion homeostasis|neuron projection terminus|negative regulation of muscle contraction|cell death|negative regulation of cellular component movement|excretion|leading edge membrane|negative regulation of cell proliferation|response to hypoxia|regulation of blood pressure|positive regulation of secretion|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|heat shock protein binding|cell projection membrane|negative regulation of synaptic transmission|negative regulation of lipid metabolic process|regulation of hormone levels|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|response to temperature stimulus|regulation of receptor activity|circadian behavior|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|negative regulation of cell motility|regulation of body fluid levels|circulatory system process|negative regulation of ion transport|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|phagocytosis|G-protein coupled receptor signaling pathway|long term synaptic depression|regulation of tube size|muscle contraction|positive regulation of nucleoside transport|establishment of protein localization to membrane|regulation of synaptic plasticity|cell surface receptor signaling pathway|positive regulation of peptide secretion|renal system process involved in regulation of systemic arterial blood pressure|axon|macromolecule modification|renal filtration|regulation of epidermal growth factor-activated receptor activity|neuron spine|body fluid secretion|regulation of inflammatory response|lipid catabolic process|negative regulation of synaptic transmission, GABAergic|negative regulation of programmed cell death|protein heterodimerization activity|chemical homeostasis|regulation of respiratory gaseous exchange by neurological system process|regulation of circadian sleep/wake cycle, sleep|temperature homeostasis|regulation of postsynaptic membrane potential|purine nucleoside binding|protein transport|regulation of renal sodium excretion|regulation of excretion|regulation of muscle system process|negative regulation of striated muscle contraction|heterotrimeric G-protein binding|regulation of cell migration|regulation of lipid catabolic process|negative regulation of glutamate secretion|positive regulation of transferase activity|G-protein beta/gamma-subunit complex binding|protein modification process|intracellular transport|amide transport|ion transport|inflammatory response|main axon|axon terminus|sensory perception|regulation of secretion|detection of temperature stimulus|protein localization to membrane|negative regulation of synaptic transmission, glutamatergic|regulation of ERBB signaling pathway|negative regulation of circadian sleep/wake cycle, non-REM sleep|negative regulation of blood pressure|negative regulation of inflammatory response|positive regulation of blood pressure|regulation of synaptic transmission, glutamatergic|dendrite|negative regulation of lipid catabolic process|regulation of neurological system process|hormone transport|axolemma|mucus secretion|positive regulation of protein metabolic process|G-protein coupled receptor binding|detection of temperature stimulus involved in sensory perception|regulation of ion transport|negative regulation of cell migration|cellular protein localization|positive regulation of potassium ion transport|positive regulation of cellular protein metabolic process|negative regulation of heart contraction|programmed cell death|lipase activity|regulation of respiratory system process|phosphate-containing compound metabolic process|intracellular signal transduction|relaxation of muscle|cellular protein metabolic process|regulation of phosphorus metabolic process|circadian sleep/wake cycle, non-REM sleep|nervous system development|regulation of lipid metabolic process|secretion|cognition|regulation of protein metabolic process|negative regulation of smooth muscle contraction|carbohydrate derivative transport|circadian sleep/wake cycle|regulation of intracellular signal transduction|blood circulation|glutamate secretion|G-protein coupled receptor activity|positive regulation of ERBB signaling pathway|phosphoric ester hydrolase activity|regulation of programmed cell death|regulation of synaptic transmission, GABAergic|negative regulation of vasodilation|regulation of systemic arterial blood pressure|amine transport|apoptotic signaling pathway|positive regulation of receptor activity|circadian sleep/wake cycle process|striated muscle contraction|regulation of heart contraction|peptide secretion|phospholipase activity|nucleoside transport|regulation of glomerular filtration|dephosphorylation|anion transport|organic anion transport|regulation of glutamate secretion|regulation of acute inflammatory response|sensory perception of temperature stimulus|positive regulation of protein modification process|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|positive regulation of epidermal growth factor receptor signaling pathway|smooth muscle contraction|regulation of vasodilation|sensory perception of pain|phosphoric diester hydrolase activity|G-protein coupled adenosine receptor activity|regulation of muscle contraction|regulation of MAPK cascade|regulation of epidermal growth factor receptor signaling pathway|heart contraction|cation transport|phosphorylation|acute inflammatory response|peptide transport|positive regulation of epidermal growth factor-activated receptor activity|protein targeting|carboxylic acid transport|intracellular protein transport|enzyme linked receptor protein signaling pathway|regulation of circadian sleep/wake cycle, non-REM sleep|negative regulation of cardiac muscle contraction|positive regulation of MAPK cascade|regulation of apoptotic process|regulation of anion transport|detection of temperature stimulus involved in sensory perception of pain|ion homeostasis|negative regulation of apoptotic process|amino acid transport|regulation of long term synaptic depression|excitatory postsynaptic potential|endocytosis|relaxation of smooth muscle|cellular protein modification process|glomerular filtration|protein targeting to membrane|relaxation of vascular smooth muscle|acid secretion|hormone secretion|regulation of kinase activity|apoptotic process|regulation of blood vessel size|negative regulation of acute inflammatory response|positive regulation of kinase activity|protein dephosphorylation|regulation of protein dephosphorylation|activation of MAPKK activity|phospholipase C activity|regulation of protein kinase activity|positive regulation of protein kinase activity|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|regulation of smooth muscle contraction|regulation of sensory perception of pain|regulation of potassium ion transport|protein phosphorylation|dicarboxylic acid transport|positive regulation of protein dephosphorylation|regulation of striated muscle contraction|vasodilation|regulation of MAP kinase activity|cardiac muscle contraction|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|regulation of cardiac muscle contraction|metal ion transport|positive regulation of protein phosphorylation|positive regulation of dephosphorylation|adenosine receptor signaling pathway|monovalent inorganic cation transport|positive regulation of phosphorylation|regulation of dephosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|potassium ion transport|regulation of peptidyl-tyrosine phosphorylation|regulation of protein tyrosine kinase activity|neuron-neuron synaptic transmission|metal ion homeostasis|regulation of protein serine/threonine kinase activity|positive regulation of protein tyrosine kinase activity|activation of protein kinase activity|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|epidermal growth factor receptor signaling pathway|synaptic transmission, GABAergic|synaptic transmission, glutamatergic|sodium ion homeostasis K04265 adenosine A1 receptor[-] hsa04080|hsa04024|hsa04022|hsa04071|hsa05032|hsa04924|hsa04923 Neuroactive ligand-receptor interaction - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|Renin secretion - Homo sapiens (human)|Regulation of lipolysis in adipocytes - Homo sapiens (human) 1:203090654-203167405 147 189 265 394 376 506 0.854844681888934 0.998876234594048 1.38940726034444 2.05287918368434 1.79401166665483 2.75771277261998 1.08104272560914 2.20153454098638 -1.02608593637798 0.000167686357513966 0.00125152712930549 DOWN ENSG00000119737 GPR75 G protein-coupled receptor 75 [Source:HGNC Symbol;Acc:HGNC:4526] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0010941|GO:0005887|GO:0004888|GO:0031226|GO:0007154|GO:0007165|GO:0008219|GO:0016021|GO:0010033|GO:0007186|GO:0007166|GO:0004896|GO:0034097|GO:0070997|GO:1901214|GO:0071310|GO:0008528|GO:0004930|GO:0019221|GO:0071345|GO:0004950|GO:0016493|GO:0070098 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|regulation of cell death|integral component of plasma membrane|transmembrane signaling receptor activity|intrinsic component of plasma membrane|cell communication|signal transduction|cell death|integral component of membrane|response to organic substance|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|cytokine receptor activity|response to cytokine|neuron death|regulation of neuron death|cellular response to organic substance|G-protein coupled peptide receptor activity|G-protein coupled receptor activity|cytokine-mediated signaling pathway|cellular response to cytokine stimulus|chemokine receptor activity|C-C chemokine receptor activity|chemokine-mediated signaling pathway - - - - 2:53852913-53859989 67 90 43 23 32 28 2.24084190583839 2.73562987570508 1.29662227580524 0.689232884563204 0.878113278399155 0.877641806537736 2.09103135244957 0.814995989833365 1.35934982780143 0.000168447425869409 0.00125657907343961 UP ENSG00000249476 CTD-2587M2.1 - - - - - - - 5:109237120-109326369 0 0 2 8 4 19 0 0 0.0233149522927119 0.092679002166821 0.0424303907219052 0.230226685373322 0.0077716507642373 0.121778692754016 -3.96989684936367 0.000168709667897508 0.00125822094064757 DOWN ENSG00000279504 AD001527.4 - - - - - - - 19:36114362-36115146 1 1 1 16 3 15 0.0901486540415463 0.0819334098559737 0.0812034112354707 1.29175735477364 0.221823645100795 1.26678626008481 0.0844284917109969 0.926789086653082 -3.45643920978765 0.000168759411619331 0.00125827759102984 DOWN ENSG00000110876 SELPLG selectin P ligand [Source:HGNC Symbol;Acc:HGNC:10722] GO:0040011|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0045321|GO:0006950|GO:0050900|GO:0048870|GO:0007155|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0016032|GO:0001931|GO:0050817|GO:0045123|GO:0005102|GO:0001618|GO:0005887|GO:0009611|GO:0006928|GO:0001775|GO:0031226|GO:0016477|GO:0016021|GO:0050902|GO:0010033|GO:0050878|GO:0051701|GO:0034097|GO:0007596|GO:0042060|GO:0007599|GO:0019058|GO:0071310|GO:0046718|GO:0071345|GO:0030260|GO:0070741|GO:0071354 locomotion|immune system process|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|leukocyte activation|response to stress|leukocyte migration|cell motility|cell adhesion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|viral process|uropod|coagulation|cellular extravasation|receptor binding|virus receptor activity|integral component of plasma membrane|response to wounding|movement of cell or subcellular component|cell activation|intrinsic component of plasma membrane|cell migration|integral component of membrane|leukocyte adhesive activation|response to organic substance|regulation of body fluid levels|interaction with host|response to cytokine|blood coagulation|wound healing|hemostasis|viral life cycle|cellular response to organic substance|viral entry into host cell|cellular response to cytokine stimulus|entry into host cell|response to interleukin-6|cellular response to interleukin-6 K06544 selectin P ligand[-] hsa04514|hsa05150 Cell adhesion molecules (CAMs) - Homo sapiens (human)|Staphylococcus aureus infection - Homo sapiens (human) 12:108622277-108633959 18 14 16 2 4 7 0.228471271131503 0.161496900970209 0.183105837421033 0.0227456854860343 0.0416538072204456 0.0832712604332368 0.191024669840915 0.0492235843799056 1.95633734544361 0.000169460265366865 0.00126270188913992 UP ENSG00000253797 UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) [Source:HGNC Symbol;Acc:HGNC:20321] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0043229|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0019953|GO:0044237|GO:0043227|GO:0032504|GO:0005622|GO:0048856|GO:0048609|GO:0007049|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0043231|GO:0030529|GO:0006139|GO:0007276|GO:0048869|GO:0022613|GO:0005730|GO:0048232|GO:0030684|GO:0042254|GO:0031981|GO:0010467|GO:0030154|GO:0016070|GO:0005634|GO:0007283|GO:0006364|GO:0006396|GO:0034660|GO:0032040|GO:0016072 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|sexual reproduction|cellular metabolic process|membrane-bounded organelle|multicellular organism reproduction|intracellular|anatomical structure development|multicellular organismal reproductive process|cell cycle|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|gamete generation|cellular developmental process|ribonucleoprotein complex biogenesis|nucleolus|male gamete generation|preribosome|ribosome biogenesis|nuclear lumen|gene expression|cell differentiation|RNA metabolic process|nucleus|spermatogenesis|rRNA processing|RNA processing|ncRNA metabolic process|small-subunit processome|rRNA metabolic process K14567 U3 small nucleolar RNA-associated protein 14[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 13:52024691-52033600 24 208 91 38 14 13 0.307048611268739 2.41847690946762 1.04967188656476 0.435595637700791 0.146959026602882 0.155879132467198 1.25839913576704 0.246144598923624 2.35401159665195 0.000169808095009697 0.00126483305100287 UP ENSG00000215187 FAM166B family with sequence similarity 166 member B [Source:HGNC Symbol;Acc:HGNC:34242] - - - - - - 9:35561831-35563899 1 1 3 12 8 13 0.0207101824473555 0.0188228641313841 0.055985010773565 0.222584205818559 0.135888632317243 0.252225848232701 0.0318393524507682 0.203566228789501 -2.67661534144332 0.000170030121664613 0.00126617092845482 DOWN ENSG00000152253 SPC25 SPC25, NDC80 kinetochore complex component [Source:HGNC Symbol;Acc:HGNC:24031] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0007049|GO:0022402|GO:0000776|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0007059|GO:0051301|GO:0007017|GO:0031262|GO:0006996|GO:0005829|GO:1903047|GO:0007010|GO:0000278|GO:0007051|GO:0005694|GO:0035556|GO:0007067|GO:0000226|GO:0005634|GO:0000777|GO:0000793|GO:0007052|GO:0007264|GO:0000775|GO:0000779 macromolecular complex|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|protein complex|cell cycle|cell cycle process|kinetochore|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|chromosome segregation|cell division|microtubule-based process|Ndc80 complex|organelle organization|cytosol|mitotic cell cycle process|cytoskeleton organization|mitotic cell cycle|spindle organization|chromosome|intracellular signal transduction|mitotic nuclear division|microtubule cytoskeleton organization|nucleus|condensed chromosome kinetochore|condensed chromosome|mitotic spindle organization|small GTPase mediated signal transduction|chromosome, centromeric region|condensed chromosome, centromeric region - - - - 2:168834132-168913371 105 114 136 252 300 209 3.74175745328779 3.6920667188987 4.3695792576785 8.04607652958488 8.77152172357347 6.98009254544238 3.934467809955 7.93256359953358 -1.01161867814327 0.000170234693814831 0.00126737819180747 DOWN ENSG00000163945 UVSSA UV stimulated scaffold protein A [Source:HGNC Symbol;Acc:HGNC:29304] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006281|GO:0006725|GO:0009314|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0019899|GO:0032403|GO:0006139|GO:0019538|GO:0043412|GO:0036211|GO:0070063|GO:0031981|GO:0005654|GO:0006259|GO:0005694|GO:0044267|GO:0000993|GO:0006289|GO:0005634|GO:0009416|GO:0006974|GO:0009411|GO:0043175|GO:0006283|GO:0006464|GO:0032446|GO:0016567 cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|DNA repair|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|enzyme binding|protein complex binding|nucleobase-containing compound metabolic process|protein metabolic process|macromolecule modification|protein modification process|RNA polymerase binding|nuclear lumen|nucleoplasm|DNA metabolic process|chromosome|cellular protein metabolic process|RNA polymerase II core binding|nucleotide-excision repair|nucleus|response to light stimulus|cellular response to DNA damage stimulus|response to UV|RNA polymerase core enzyme binding|transcription-coupled nucleotide-excision repair|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination - - - - 4:1347266-1388049 24 46 84 121 134 189 0.127798236352368 0.222614867181361 0.403283865629062 0.577295591197892 0.585448769803154 0.943206658001924 0.251232323054264 0.70198367300099 -1.48241538571457 0.000170472237540146 0.00126883026166131 DOWN ENSG00000131779 PEX11B peroxisomal biogenesis factor 11 beta [Source:HGNC Symbol;Acc:HGNC:8853] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0043234|GO:0031090|GO:0042802|GO:0032535|GO:0031982|GO:0022607|GO:0031231|GO:0043231|GO:0005737|GO:0046983|GO:0007154|GO:0007165|GO:0070062|GO:0016021|GO:0031301|GO:0006996|GO:0044375|GO:0007031|GO:0006461|GO:0005779|GO:0042803|GO:0005778|GO:0051259|GO:0005777|GO:0016559|GO:0051260 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|protein complex|organelle membrane|identical protein binding|regulation of cellular component size|vesicle|cellular component assembly|intrinsic component of peroxisomal membrane|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|cell communication|signal transduction|extracellular exosome|integral component of membrane|integral component of organelle membrane|organelle organization|regulation of peroxisome size|peroxisome organization|protein complex assembly|integral component of peroxisomal membrane|protein homodimerization activity|peroxisomal membrane|protein oligomerization|peroxisome|peroxisome fission|protein homooligomerization K13352 peroxin-11B[-] hsa04146 Peroxisome - Homo sapiens (human) 1:145911350-145918837 70 65 153 123 446 410 1.33070362515943 1.12300592845939 2.62236182108548 2.0950164844629 6.95647412083472 7.30463327301363 1.6920237915681 5.45204129277042 -1.68804663454084 0.000170787054500668 0.00127085661143144 DOWN ENSG00000181894 ZNF329 zinc finger protein 329 [Source:HGNC Symbol;Acc:HGNC:14209] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:58126252-58155110 95 111 80 45 48 51 0.487238011480983 0.517395660921881 0.369932617679061 0.206789601942394 0.201987701255896 0.245141829666911 0.458188763360642 0.2179730442884 1.07179234371237 0.000170832096500329 0.00127087500845274 UP ENSG00000278615 C11orf98 chromosome 11 open reading frame 98 [Source:HGNC Symbol;Acc:HGNC:51238] - - - - - - 11:62662816-62665217 1670 1804 1162 1146 701 610 73.3730122870771 72.0338357134091 46.029913489393 45.1130562704192 25.270043409474 25.1176285008925 63.8122538299597 31.8335760602619 1.00328425764886 0.000171205498487726 0.00127333556349092 UP ENSG00000258384 AC068831.6 - - - - - - - 15:90952239-90955225 27 21 26 11 6 8 1.02793627073402 0.726622049686937 0.892444888891719 0.375219224741205 0.187408504552914 0.285444822267033 0.882334403104225 0.282690850520384 1.64210034804207 0.000172461612026668 0.00128203908502095 UP ENSG00000188368 PRR19 proline rich 19 [Source:HGNC Symbol;Acc:HGNC:33728] GO:0005488|GO:0005515 binding|protein binding - - - - 19:42302098-42310821 69 53 32 14 27 15 0.926860569074161 0.647029516682217 0.387548597710045 0.168502076812701 0.297571152409859 0.188839197524986 0.653812894488808 0.218304142249182 1.58253832494573 0.000172801963981844 0.00128392977419462 UP ENSG00000258769 RAP1AP RAP1A, member of RAS oncogene family pseudogene [Source:HGNC Symbol;Acc:HGNC:9856] - - - - - - 14:74482985-74483435 17 24 25 6 9 8 2.66630532282318 3.42105376917443 3.53529473556756 0.843204247541038 1.15817419703645 1.17595671789833 3.20755127585506 1.05911172082527 1.59861754777217 0.000173829619630765 0.00128996009556472 UP ENSG00000262712 RP11-295D4.1 - - - - - - - 16:4335870-4337818 135 183 56 49 55 27 4.89967249572607 6.03622714475505 1.83248033014993 1.59341487963922 1.63780533851462 0.91838208078481 4.25612665687702 1.38320076631288 1.62153051086758 0.000173815914642328 0.00128996009556472 UP ENSG00000249661 TNRC18P1 trinucleotide repeat containing 18 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43881] - - - - - - 4:140641840-140645489 15 9 10 1 2 4 0.29069495197176 0.158524970786163 0.174734389032092 0.0173558338358389 0.0317995435122662 0.0726419127427047 0.207984770596672 0.0405990966969366 2.35695835897288 0.000174176338170794 0.00129221182896394 UP ENSG00000150667 FSIP1 fibrous sheath interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21674] GO:0005488|GO:0005515 binding|protein binding - - - - 15:39600031-39782830 3 3 1 12 15 14 0.0694937194888487 0.06316055366571 0.0208725205696937 0.24904067821939 0.285068659355497 0.303910107658434 0.0511755979080841 0.279339815077774 -2.4484932614646 0.000174401264987037 0.00129355909687528 DOWN ENSG00000233868 AC009302.2 - - - - - - - 2:221944223-221944612 149 123 86 59 60 50 27.0251226574188 20.2753040522652 14.0635358333587 9.58813878585944 8.92892948715098 8.49925735740594 20.4546541810142 9.00544187680545 1.18356017355477 0.000174601237819472 0.00129472065421324 UP ENSG00000260286 C6orf229 chromosome 6 open reading frame 229 [Source:HGNC Symbol;Acc:HGNC:49394] - - - - - - 6:24797321-24798889 9 6 4 0 1 0 0.782107121631369 0.473862177486999 0.313405660917511 0 0.0713307464181234 0 0.523124986678626 0.0237769154727078 4.45952220626522 0.000174911537918539 0.00129669954135089 UP ENSG00000276232 SCARNA10 - - - - - - - 12:6510275-6510522 9 7 8 1 1 1 2.56707740729006 1.81468362585224 2.05735651602302 0.255438683471016 0.234125917678841 0.267281231361766 2.14637251638844 0.252281944170541 3.08879162520587 0.000175029189796755 0.00129692763271092 UP ENSG00000188316 ENO4 enolase family member 4 [Source:HGNC Symbol;Acc:HGNC:31670] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0006807|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0005622|GO:0043234|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0043169|GO:0005737|GO:0005975|GO:0051186|GO:0006139|GO:0055086|GO:0006091|GO:0005829|GO:0046872|GO:0019693|GO:0000015|GO:0009116|GO:0016836|GO:0016052|GO:0006796|GO:0006757|GO:0009259|GO:0009117|GO:0000287|GO:0016310|GO:0009132|GO:0006163|GO:0019752|GO:0004634|GO:0006096|GO:0042278|GO:0046939|GO:0032787|GO:0006165|GO:0046034|GO:0046031|GO:0006090 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|intracellular|protein complex|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|cation binding|cytoplasm|carbohydrate metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|generation of precursor metabolites and energy|cytosol|metal ion binding|ribose phosphate metabolic process|phosphopyruvate hydratase complex|nucleoside metabolic process|hydro-lyase activity|carbohydrate catabolic process|phosphate-containing compound metabolic process|ATP generation from ADP|ribonucleotide metabolic process|nucleotide metabolic process|magnesium ion binding|phosphorylation|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|carboxylic acid metabolic process|phosphopyruvate hydratase activity|glycolytic process|purine nucleoside metabolic process|nucleotide phosphorylation|monocarboxylic acid metabolic process|nucleoside diphosphate phosphorylation|ATP metabolic process|ADP metabolic process|pyruvate metabolic process - - - - 10:116849512-116911788 0 3 1 13 5 18 0 0.0422268675339488 0.0139546142337663 0.180367562343001 0.0635288737355288 0.261226893673321 0.0187271605892384 0.168374443250617 -3.16846909530425 0.00017646094368076 0.0013059768305119 DOWN ENSG00000122547 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 [Source:HGNC Symbol;Acc:HGNC:22223] GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0006281|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0006139|GO:0003677|GO:0006259|GO:0006974 cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|nucleobase-containing compound metabolic process|DNA binding|DNA metabolic process|cellular response to DNA damage stimulus - - - - 7:36153149-36301543 66 67 123 181 202 204 0.580528965111364 0.535598068136723 0.97543730121334 1.42645082733882 1.45781091950783 1.68166929359166 0.697188111487142 1.52197701347944 -1.12632669606282 0.000177633555947928 0.0013132917729741 DOWN ENSG00000253187 HOXA10-AS HOXA10 antisense RNA [Source:HGNC Symbol;Acc:HGNC:40281] - - - - - - 7:27168619-27171915 287 281 169 120 152 81 7.43372147560688 6.61470608160981 3.94660945435839 2.78485750273599 3.23023602482313 1.96625797989717 5.99834567052503 2.66045050248543 1.17289410119769 0.000178860929476726 0.00132105744398768 UP ENSG00000121749 TBC1D15 TBC1 domain family member 15 [Source:HGNC Symbol;Acc:HGNC:25694] GO:0005623|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0043229|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0008047|GO:0031982|GO:0043231|GO:0005737|GO:0043085|GO:0070062|GO:0050790|GO:0005096|GO:0051345|GO:0030695|GO:0005739|GO:0043087|GO:0043547 cell|extracellular region|metabolic process|binding|extracellular vesicle|intracellular organelle|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|enzyme activator activity|vesicle|intracellular membrane-bounded organelle|cytoplasm|positive regulation of catalytic activity|extracellular exosome|regulation of catalytic activity|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|mitochondrion|regulation of GTPase activity|positive regulation of GTPase activity - - - - 12:71839707-71927248 192 208 383 486 577 584 1.22609972876561 1.2071642892883 2.20514216894292 2.78072298235343 3.02320213959438 3.49514678670805 1.54613539566561 3.09969063621862 -1.00345757274884 0.00017906762388849 0.00132160317517107 DOWN ENSG00000179148 ALOXE3 arachidonate lipoxygenase 3 [Source:HGNC Symbol;Acc:HGNC:13743] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0016491|GO:0050794|GO:0006807|GO:0016829|GO:0071704|GO:0043167|GO:0044237|GO:0016853|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0044255|GO:0051213|GO:0006082|GO:0007275|GO:0048513|GO:0050877|GO:0034641|GO:0016701|GO:0044281|GO:0043169|GO:0005737|GO:0042592|GO:0048871|GO:0051120|GO:0007154|GO:0006629|GO:0007165|GO:0048869|GO:0044249|GO:0050878|GO:0055114|GO:0006665|GO:0046872|GO:0050891|GO:0048878|GO:0006631|GO:0006643|GO:0007600|GO:0016702|GO:0043588|GO:0043603|GO:0008610|GO:0030154|GO:0006690|GO:0030522|GO:0019372|GO:0033559|GO:0006672|GO:0045444|GO:0019233|GO:0035357|GO:0001676|GO:0061436|GO:0030104|GO:0019369|GO:0006633|GO:0046914|GO:0019752|GO:0030148|GO:0033561|GO:0046513|GO:0006636|GO:0005506|GO:0051121|GO:0043651|GO:0032787|GO:0042759|GO:0051122 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|oxidoreductase activity|regulation of cellular process|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|ion binding|cellular metabolic process|isomerase activity|biosynthetic process|intracellular|protein binding|anatomical structure development|cellular lipid metabolic process|dioxygenase activity|organic acid metabolic process|multicellular organism development|animal organ development|neurological system process|cellular nitrogen compound metabolic process|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen|small molecule metabolic process|cation binding|cytoplasm|homeostatic process|multicellular organismal homeostasis|hepoxilin A3 synthase activity|cell communication|lipid metabolic process|signal transduction|cellular developmental process|cellular biosynthetic process|regulation of body fluid levels|oxidation-reduction process|sphingolipid metabolic process|metal ion binding|multicellular organismal water homeostasis|chemical homeostasis|fatty acid metabolic process|membrane lipid metabolic process|sensory perception|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|skin development|cellular amide metabolic process|lipid biosynthetic process|cell differentiation|icosanoid metabolic process|intracellular receptor signaling pathway|lipoxygenase pathway|unsaturated fatty acid metabolic process|ceramide metabolic process|fat cell differentiation|sensory perception of pain|peroxisome proliferator activated receptor signaling pathway|long-chain fatty acid metabolic process|establishment of skin barrier|water homeostasis|arachidonic acid metabolic process|fatty acid biosynthetic process|transition metal ion binding|carboxylic acid metabolic process|sphingolipid biosynthetic process|regulation of water loss via skin|ceramide biosynthetic process|unsaturated fatty acid biosynthetic process|iron ion binding|hepoxilin metabolic process|linoleic acid metabolic process|monocarboxylic acid metabolic process|long-chain fatty acid biosynthetic process|hepoxilin biosynthetic process - - - - 17:8095900-8119047 75 101 106 54 51 41 0.843307762586794 1.03211698214018 1.07459438349872 0.544021269169446 0.470504838201469 0.432056611705365 0.983339709408565 0.482194239692093 1.0280754866912 0.000180933401481076 0.0013347135576516 UP ENSG00000145730 PAM peptidylglycine alpha-amidating monooxygenase [Source:HGNC Symbol;Acc:HGNC:8596] GO:0032502|GO:0000003|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042995|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0009986|GO:0042698|GO:0044237|GO:0051641|GO:0044297|GO:0009653|GO:0016043|GO:0030246|GO:0043227|GO:0071944|GO:0032504|GO:0009058|GO:0031224|GO:0005615|GO:0005622|GO:0022602|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0048609|GO:0019222|GO:0007507|GO:0060341|GO:0048029|GO:0044255|GO:0006725|GO:0043025|GO:0006810|GO:1901360|GO:0006082|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0032940|GO:0031982|GO:0046483|GO:0051128|GO:0022607|GO:0030141|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0032970|GO:0016705|GO:0032880|GO:0012506|GO:0009887|GO:0043177|GO:0043005|GO:0043204|GO:0045184|GO:0036477|GO:0060135|GO:0019842|GO:0042493|GO:0006139|GO:0004497|GO:0009268|GO:0008104|GO:0007565|GO:0006629|GO:0070062|GO:0009725|GO:0030667|GO:0009404|GO:0001666|GO:0016021|GO:0030029|GO:0010035|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0048732|GO:0050878|GO:0005794|GO:0006996|GO:0055114|GO:0030879|GO:0010468|GO:0034645|GO:0005802|GO:0006518|GO:0046872|GO:0032956|GO:0033993|GO:0043412|GO:0007010|GO:0007589|GO:0072358|GO:0007417|GO:0031410|GO:0051252|GO:0006631|GO:0016715|GO:0051223|GO:0015031|GO:0010038|GO:0016023|GO:0036211|GO:0070201|GO:0051046|GO:0031418|GO:0009306|GO:0048471|GO:0031988|GO:0046688|GO:0006461|GO:0007595|GO:0030036|GO:0019900|GO:0014070|GO:0043603|GO:0030659|GO:0042476|GO:0033043|GO:0044267|GO:0031406|GO:0010467|GO:0007399|GO:0046903|GO:0009059|GO:0060173|GO:0016070|GO:0072359|GO:0048545|GO:0097305|GO:0051259|GO:0004504|GO:0032774|GO:0001676|GO:2001141|GO:0050708|GO:0043627|GO:0005509|GO:0004598|GO:0051493|GO:0032355|GO:0046914|GO:0019752|GO:0019901|GO:0006464|GO:0031960|GO:0006351|GO:0006355|GO:0051384|GO:0006366|GO:0006357|GO:0001519|GO:0005507|GO:1903506|GO:0018032|GO:0032787|GO:0051260|GO:0008270 developmental process|reproduction|cell|rhythmic process|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cell projection|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|cell surface|ovulation cycle|cellular metabolic process|cellular localization|cell body|anatomical structure morphogenesis|cellular component organization|carbohydrate binding|membrane-bounded organelle|cell periphery|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|extracellular space|intracellular|ovulation cycle process|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|heart development|regulation of cellular localization|monosaccharide binding|cellular lipid metabolic process|cellular aromatic compound metabolic process|neuronal cell body|transport|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|secretion by cell|vesicle|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|secretory granule|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|regulation of actin filament-based process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|regulation of protein localization|vesicle membrane|organ morphogenesis|organic acid binding|neuron projection|perikaryon|establishment of protein localization|somatodendritic compartment|maternal process involved in female pregnancy|vitamin binding|response to drug|nucleobase-containing compound metabolic process|monooxygenase activity|response to pH|protein localization|female pregnancy|lipid metabolic process|extracellular exosome|response to hormone|secretory granule membrane|toxin metabolic process|response to hypoxia|integral component of membrane|actin filament-based process|response to inorganic substance|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|gland development|regulation of body fluid levels|Golgi apparatus|organelle organization|oxidation-reduction process|mammary gland development|regulation of gene expression|cellular macromolecule biosynthetic process|trans-Golgi network|peptide metabolic process|metal ion binding|regulation of actin cytoskeleton organization|response to lipid|macromolecule modification|cytoskeleton organization|body fluid secretion|cardiovascular system development|central nervous system development|cytoplasmic vesicle|regulation of RNA metabolic process|fatty acid metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen|regulation of protein transport|protein transport|response to metal ion|cytoplasmic, membrane-bounded vesicle|protein modification process|regulation of establishment of protein localization|regulation of secretion|L-ascorbic acid binding|protein secretion|perinuclear region of cytoplasm|membrane-bounded vesicle|response to copper ion|protein complex assembly|lactation|actin cytoskeleton organization|kinase binding|response to organic cyclic compound|cellular amide metabolic process|cytoplasmic vesicle membrane|odontogenesis|regulation of organelle organization|cellular protein metabolic process|carboxylic acid binding|gene expression|nervous system development|secretion|macromolecule biosynthetic process|limb development|RNA metabolic process|circulatory system development|response to steroid hormone|response to alcohol|protein oligomerization|peptidylglycine monooxygenase activity|RNA biosynthetic process|long-chain fatty acid metabolic process|regulation of RNA biosynthetic process|regulation of protein secretion|response to estrogen|calcium ion binding|peptidylamidoglycolate lyase activity|regulation of cytoskeleton organization|response to estradiol|transition metal ion binding|carboxylic acid metabolic process|protein kinase binding|cellular protein modification process|response to corticosteroid|transcription, DNA-templated|regulation of transcription, DNA-templated|response to glucocorticoid|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|peptide amidation|copper ion binding|regulation of nucleic acid-templated transcription|protein amidation|monocarboxylic acid metabolic process|protein homooligomerization|zinc ion binding - - - - 5:102753981-103031105 505 484 1017 1192 1373 1727 1.83284448142741 1.59646562624861 3.32789003579463 3.87621403688379 4.08857894483055 5.87428772110832 2.25240004782355 4.61302690094089 -1.03425061889327 0.000181417958324017 0.00133750780989008 DOWN ENSG00000139428 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type [Source:HGNC Symbol;Acc:HGNC:19331] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0016740|GO:0006725|GO:1901360|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0046483|GO:0043231|GO:0005737|GO:0016765|GO:0009235|GO:0000166|GO:0044249|GO:0035639|GO:0001883|GO:0032549|GO:0008817|GO:0005759|GO:0005739|GO:0017076|GO:0009236|GO:0006766|GO:0033014|GO:0005524|GO:0030554|GO:0006767 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|transferase activity, transferring alkyl or aryl (other than methyl) groups|cobalamin metabolic process|nucleotide binding|cellular biosynthetic process|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|cob(I)yrinic acid a,c-diamide adenosyltransferase activity|mitochondrial matrix|mitochondrion|purine nucleotide binding|cobalamin biosynthetic process|vitamin metabolic process|tetrapyrrole biosynthetic process|ATP binding|adenyl nucleotide binding|water-soluble vitamin metabolic process K00798 cob(I)alamin adenosyltransferase[2.5.1.17] hsa01100|hsa00860 Metabolic pathways - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human) 12:109553737-109573874 97 92 97 209 202 207 0.712730215045398 0.614358760909358 0.64259937392717 1.37594073194663 1.2177953063968 1.42545358836577 0.656562783293975 1.33972987556973 -1.02893726572213 0.000181790787859722 0.00133938355892501 DOWN ENSG00000115461 IGFBP5 insulin like growth factor binding protein 5 [Source:HGNC Symbol;Acc:HGNC:5474] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0023052|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0006807|GO:0016049|GO:0016942|GO:0071704|GO:0044237|GO:0048870|GO:0023051|GO:0045926|GO:0009653|GO:0016043|GO:0040008|GO:0023057|GO:0009058|GO:0005615|GO:0050793|GO:0048589|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0044262|GO:0042127|GO:0048286|GO:0045595|GO:0009888|GO:0014741|GO:0019838|GO:0035295|GO:0007275|GO:0030324|GO:0045596|GO:0048513|GO:0030279|GO:0034641|GO:0044281|GO:0031069|GO:0051128|GO:0061061|GO:0010243|GO:0001942|GO:0042567|GO:0003012|GO:0005975|GO:0006928|GO:0009887|GO:0042592|GO:0009966|GO:0048729|GO:0050673|GO:0048771|GO:0009890|GO:0001968|GO:0030323|GO:1901862|GO:0010646|GO:0007154|GO:0007565|GO:0051270|GO:0016477|GO:0007165|GO:0030278|GO:0009968|GO:0001503|GO:0009725|GO:0051271|GO:0008285|GO:0048869|GO:2000145|GO:0009967|GO:0048630|GO:0044249|GO:0019538|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0048732|GO:1902533|GO:0032268|GO:0014733|GO:0006109|GO:0030879|GO:0010468|GO:0034645|GO:0048660|GO:0005520|GO:0006518|GO:0045668|GO:0007166|GO:0014074|GO:0002009|GO:0010629|GO:0042692|GO:0043569|GO:0022405|GO:0048878|GO:0060541|GO:0046683|GO:0045667|GO:1901652|GO:0048659|GO:0022612|GO:0090257|GO:0071417|GO:0030334|GO:0032269|GO:0060537|GO:0001649|GO:0043567|GO:0043434|GO:0005996|GO:0051591|GO:0043588|GO:0044342|GO:0030336|GO:0014070|GO:0060429|GO:0043603|GO:0035556|GO:0044267|GO:0014896|GO:0010467|GO:0071310|GO:0051246|GO:0043568|GO:0009059|GO:0030154|GO:0007517|GO:1902531|GO:0060056|GO:0048662|GO:0042633|GO:1904205|GO:0051896|GO:0043491|GO:0019318|GO:0060538|GO:0043043|GO:0031994|GO:0017148|GO:0014909|GO:0014734|GO:0051897|GO:0010608|GO:0014910|GO:0008544|GO:0071407|GO:0060416|GO:0006412|GO:0010906|GO:0007167|GO:0006417|GO:0048730|GO:0051146|GO:0031995|GO:0071320|GO:0014912|GO:0014706|GO:0060443|GO:0033500|GO:0098773|GO:0042593|GO:0007519|GO:0006006|GO:0007169|GO:0048009 locomotion|developmental process|growth|macromolecular complex|reproduction|signaling|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|nitrogen compound metabolic process|cell growth|insulin-like growth factor binding protein complex|organic substance metabolic process|cellular metabolic process|cell motility|regulation of signaling|negative regulation of growth|anatomical structure morphogenesis|cellular component organization|regulation of growth|negative regulation of signaling|biosynthetic process|extracellular space|regulation of developmental process|developmental growth|protein binding|protein complex|anatomical structure development|regulation of metabolic process|cellular carbohydrate metabolic process|regulation of cell proliferation|lung alveolus development|regulation of cell differentiation|tissue development|negative regulation of muscle hypertrophy|growth factor binding|tube development|multicellular organism development|lung development|negative regulation of cell differentiation|animal organ development|negative regulation of ossification|cellular nitrogen compound metabolic process|small molecule metabolic process|hair follicle morphogenesis|regulation of cellular component organization|muscle structure development|response to organonitrogen compound|hair follicle development|insulin-like growth factor ternary complex|muscle system process|carbohydrate metabolic process|movement of cell or subcellular component|organ morphogenesis|homeostatic process|regulation of signal transduction|tissue morphogenesis|epithelial cell proliferation|tissue remodeling|negative regulation of biosynthetic process|fibronectin binding|respiratory tube development|negative regulation of muscle tissue development|regulation of cell communication|cell communication|female pregnancy|regulation of cellular component movement|cell migration|signal transduction|regulation of ossification|negative regulation of signal transduction|ossification|response to hormone|negative regulation of cellular component movement|negative regulation of cell proliferation|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|skeletal muscle tissue growth|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|gland development|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of skeletal muscle adaptation|regulation of carbohydrate metabolic process|mammary gland development|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|insulin-like growth factor binding|peptide metabolic process|negative regulation of osteoblast differentiation|cell surface receptor signaling pathway|response to purine-containing compound|morphogenesis of an epithelium|negative regulation of gene expression|muscle cell differentiation|negative regulation of insulin-like growth factor receptor signaling pathway|hair cycle process|chemical homeostasis|respiratory system development|response to organophosphorus|regulation of osteoblast differentiation|response to peptide|smooth muscle cell proliferation|gland morphogenesis|regulation of muscle system process|cellular response to organonitrogen compound|regulation of cell migration|negative regulation of cellular protein metabolic process|muscle tissue development|osteoblast differentiation|regulation of insulin-like growth factor receptor signaling pathway|response to peptide hormone|monosaccharide metabolic process|response to cAMP|skin development|type B pancreatic cell proliferation|negative regulation of cell migration|response to organic cyclic compound|epithelium development|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|muscle hypertrophy|gene expression|cellular response to organic substance|regulation of protein metabolic process|positive regulation of insulin-like growth factor receptor signaling pathway|macromolecule biosynthetic process|cell differentiation|muscle organ development|regulation of intracellular signal transduction|mammary gland involution|negative regulation of smooth muscle cell proliferation|hair cycle|negative regulation of skeletal muscle hypertrophy|regulation of protein kinase B signaling|protein kinase B signaling|hexose metabolic process|skeletal muscle organ development|peptide biosynthetic process|insulin-like growth factor I binding|negative regulation of translation|smooth muscle cell migration|skeletal muscle hypertrophy|positive regulation of protein kinase B signaling|posttranscriptional regulation of gene expression|regulation of smooth muscle cell migration|epidermis development|cellular response to organic cyclic compound|response to growth hormone|translation|regulation of glucose metabolic process|enzyme linked receptor protein signaling pathway|regulation of translation|epidermis morphogenesis|striated muscle cell differentiation|insulin-like growth factor II binding|cellular response to cAMP|negative regulation of smooth muscle cell migration|striated muscle tissue development|mammary gland morphogenesis|carbohydrate homeostasis|skin epidermis development|glucose homeostasis|skeletal muscle tissue development|glucose metabolic process|transmembrane receptor protein tyrosine kinase signaling pathway|insulin-like growth factor receptor signaling pathway - - - - 2:216672105-216695525 34 28 64 107 81 287 0.32136206068084 0.240519035036604 0.545385065617609 0.906136666914639 0.628151681870642 2.54227772486889 0.369088720445018 1.35885535788472 -1.88035234411099 0.000182500470553514 0.00134394895113582 DOWN ENSG00000215190 LINC00680 long intergenic non-protein coding RNA 680 [Source:HGNC Symbol;Acc:HGNC:44417] - - - - - - 6:57946074-57961501 212 241 98 91 82 44 2.61988892652845 2.70672086403103 1.09191397606053 1.0075879059189 0.831437878180335 0.509595628995738 2.13950792220667 0.782873804364991 1.4504273454023 0.000182843485783055 0.00134614289138528 UP ENSG00000109618 SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [Source:HGNC Symbol;Acc:HGNC:30605] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0016785|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0043603|GO:0044267|GO:0010467|GO:0051246|GO:0009059|GO:0016070|GO:0005634|GO:0043043|GO:0000049|GO:0032774|GO:0034660|GO:0010608|GO:0006412|GO:0006417|GO:0006414|GO:0006399|GO:0097056|GO:0001514 cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|transferase activity, transferring selenium-containing groups|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|cellular amide metabolic process|cellular protein metabolic process|gene expression|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|nucleus|peptide biosynthetic process|tRNA binding|RNA biosynthetic process|ncRNA metabolic process|posttranscriptional regulation of gene expression|translation|regulation of translation|translational elongation|tRNA metabolic process|selenocysteinyl-tRNA(Sec) biosynthetic process|selenocysteine incorporation K03341 O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase[2.9.1.2] hsa00970|hsa00450 Aminoacyl-tRNA biosynthesis - Homo sapiens (human)|Selenocompound metabolism - Homo sapiens (human) 4:25120014-25160442 67 74 110 176 187 187 0.482330615799735 0.484150249730424 0.713961477160317 1.13521731625592 1.10453040189399 1.26165130817648 0.560147447563492 1.16713300877546 -1.05909044001862 0.000182932218088017 0.0013464641121301 DOWN ENSG00000233967 RP11-250B2.3 - - - - - - - 6:80443344-80465927 3 4 5 14 15 34 0.138714914587545 0.168071377984495 0.208403193337711 0.579955514049468 0.569019402399796 1.47320092146668 0.171729828636584 0.874058612638648 -2.34758937701819 0.000183375437580594 0.00134939371790265 DOWN ENSG00000213221 DNLZ DNL-type zinc finger [Source:HGNC Symbol;Acc:HGNC:33879] GO:0005623|GO:0009987|GO:0005488|GO:0043229|GO:0043167|GO:0051641|GO:0016043|GO:0006457|GO:0043227|GO:0005622|GO:0005515|GO:0006810|GO:0043231|GO:0051087|GO:0043169|GO:0005737|GO:0045184|GO:0008104|GO:0055085|GO:0031647|GO:0051649|GO:0006996|GO:0046872|GO:0072594|GO:0050821|GO:0007005|GO:0015031|GO:0046907|GO:0005739|GO:0034613|GO:0017038|GO:0006626|GO:0030150|GO:0071806|GO:0033365|GO:0006839|GO:0006605|GO:0072655|GO:0006886|GO:0065002|GO:0046914|GO:0008270|GO:0070585 cell|cellular process|binding|intracellular organelle|ion binding|cellular localization|cellular component organization|protein folding|membrane-bounded organelle|intracellular|protein binding|transport|intracellular membrane-bounded organelle|chaperone binding|cation binding|cytoplasm|establishment of protein localization|protein localization|transmembrane transport|regulation of protein stability|establishment of localization in cell|organelle organization|metal ion binding|establishment of protein localization to organelle|protein stabilization|mitochondrion organization|protein transport|intracellular transport|mitochondrion|cellular protein localization|protein import|protein targeting to mitochondrion|protein import into mitochondrial matrix|protein transmembrane transport|protein localization to organelle|mitochondrial transport|protein targeting|establishment of protein localization to mitochondrion|intracellular protein transport|intracellular protein transmembrane transport|transition metal ion binding|zinc ion binding|protein localization to mitochondrion - - - - 9:136359480-136363789 126 141 61 45 47 47 2.43652993361459 2.47800437884272 1.06352133659621 0.779672550571212 0.745710571209923 0.851791452502778 1.99268521635117 0.792391524761304 1.3304284715586 0.000183769222771505 0.00135195820025148 UP ENSG00000120925 RNF170 ring finger protein 170 [Source:HGNC Symbol;Acc:HGNC:25358] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0031224|GO:0016874|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0043169|GO:0005737|GO:0005783|GO:0016021|GO:0019538|GO:0046872|GO:0043412|GO:0036211|GO:0044267|GO:0046914|GO:0006464|GO:0008270|GO:0032446|GO:0016567 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|ligase activity|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cation binding|cytoplasm|endoplasmic reticulum|integral component of membrane|protein metabolic process|metal ion binding|macromolecule modification|protein modification process|cellular protein metabolic process|transition metal ion binding|cellular protein modification process|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 8:42849637-42897290 89 82 142 217 225 251 0.47020578659024 0.39372311378622 0.676392291442107 1.02719875488033 0.975322162643422 1.24279913304349 0.513440397272856 1.08177335018908 -1.07512954569074 0.00018400115631343 0.00135299766516777 DOWN ENSG00000149243 KLHL35 kelch like family member 35 [Source:HGNC Symbol;Acc:HGNC:26597] GO:0005488|GO:0005515 binding|protein binding - - - - 11:75422394-75430629 50 49 46 112 127 102 0.453379139764908 0.403808258753016 0.376070201704279 0.909934498028113 0.9448574835305 0.866810951100124 0.411085866740734 0.907200977552912 -1.14198242240196 0.000184160400598592 0.00135383516362235 DOWN ENSG00000197808 ZNF461 zinc finger protein 461 [Source:HGNC Symbol;Acc:HGNC:21629] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:36637192-36666853 127 180 110 72 62 74 0.593681812753423 0.764718105619383 0.463612574317821 0.301565764688607 0.237797438131685 0.324199035732537 0.607337497563542 0.28785407951761 1.07716078670568 0.000187758274957747 0.00137790942492345 UP ENSG00000225973 PIGBOS1 PIGB opposite strand 1 [Source:HGNC Symbol;Acc:HGNC:50696] GO:0005576 extracellular region - - - - 15:55317184-55319161 11 13 9 34 35 34 0.381797018108079 0.41009094783404 0.281633510202921 1.05735273327789 0.996732652217045 1.10598499010992 0.357840492048347 1.05335679186828 -1.55760563489387 0.000189099007789531 0.00138706677605618 DOWN ENSG00000232995 RGS5 regulator of G-protein signaling 5 [Source:EntrezGene;Acc:8490] - - - - - - 1:163244505-163321894 7 12 18 43 44 29 0.092867230140961 0.144682600327988 0.215304751676827 0.511117870363058 0.478934303841293 0.360558545799893 0.150951527381925 0.450203573334748 -1.57649215309566 0.000189271652023457 0.00138799211483869 DOWN ENSG00000141994 DUS3L dihydrouridine synthase 3-like [Source:HGNC Symbol;Acc:HGNC:26920] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0048037|GO:0005622|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0046483|GO:0043169|GO:0005737|GO:0006139|GO:0016627|GO:0050662|GO:0000166|GO:0055114|GO:0005829|GO:0046872|GO:0003723|GO:0043412|GO:0017150|GO:0050660|GO:0010467|GO:0016070|GO:0006396|GO:0034660|GO:0009451|GO:0044822|GO:0006400|GO:0006399|GO:0008033|GO:0002943 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cofactor binding|intracellular|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|heterocycle metabolic process|cation binding|cytoplasm|nucleobase-containing compound metabolic process|oxidoreductase activity, acting on the CH-CH group of donors|coenzyme binding|nucleotide binding|oxidation-reduction process|cytosol|metal ion binding|RNA binding|macromolecule modification|tRNA dihydrouridine synthase activity|flavin adenine dinucleotide binding|gene expression|RNA metabolic process|RNA processing|ncRNA metabolic process|RNA modification|poly(A) RNA binding|tRNA modification|tRNA metabolic process|tRNA processing|tRNA dihydrouridine synthesis - - - - 19:5784832-5791238 529 650 378 294 325 138 3.98040747949421 4.44493215622922 2.56435516642634 1.98205823681406 2.00642612233421 0.97314765770998 3.66323160071659 1.65387733895275 1.14726467560484 0.000191656370168025 0.00140341164459069 UP ENSG00000168661 ZNF30 zinc finger protein 30 [Source:HGNC Symbol;Acc:HGNC:13090] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:34926903-34945170 272 272 149 113 133 89 1.9403445719227 1.76342740676754 0.958319496598652 0.722248076929222 0.778448603451964 0.595018860717157 1.55403049176296 0.698571847032781 1.15353440393483 0.000192304986886157 0.00140747072284857 UP ENSG00000101901 ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit [Source:HGNC Symbol;Acc:HGNC:30881] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0044255|GO:0003676|GO:0043231|GO:0008233|GO:0005737|GO:0005975|GO:0006629|GO:0005783|GO:0016757|GO:0044249|GO:0019538|GO:0006490|GO:0034645|GO:0003723|GO:0043412|GO:0006487|GO:0008194|GO:0009100|GO:0036211|GO:0016758|GO:0006508|GO:0070085|GO:1901137|GO:0044267|GO:0009059|GO:0009101|GO:0043413|GO:0008375|GO:0006488|GO:0018279|GO:0044822|GO:0008234|GO:0006464|GO:0004577|GO:0018193|GO:0043687 cell|membrane|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|protein glycosylation|cellular lipid metabolic process|nucleic acid binding|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|carbohydrate metabolic process|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular biosynthetic process|protein metabolic process|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|RNA binding|macromolecule modification|protein N-linked glycosylation|UDP-glycosyltransferase activity|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|proteolysis|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|acetylglucosaminyltransferase activity|dolichol-linked oligosaccharide biosynthetic process|protein N-linked glycosylation via asparagine|poly(A) RNA binding|cysteine-type peptidase activity|cellular protein modification process|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity|peptidyl-amino acid modification|post-translational protein modification K07432 beta-1,4-N-acetylglucosaminyltransferase[2.4.1.141] hsa01100|hsa00510 Metabolic pathways - Homo sapiens (human)|N-Glycan biosynthesis - Homo sapiens (human) X:111665811-111760649 167 215 169 334 488 360 0.600135553261999 0.702184534223624 0.547560984548504 1.0754165550879 1.43886657071164 1.21244818327044 0.616627024011376 1.24224376968999 -1.01047828342892 0.000192964952483056 0.00141161515146779 DOWN ENSG00000248124 RRN3P1 RRN3 homolog, RNA polymerase I transcription factor pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:30548] - - - - - - 16:21796106-21820410 109 123 61 48 47 26 1.04532575875392 1.07204020883723 0.527435066332554 0.412439355843814 0.369822297923793 0.233682338675688 0.881600344641235 0.338647997481098 1.38033832316787 0.000192965814736386 0.00141161515146779 UP ENSG00000147437 GNRH1 gonadotropin releasing hormone 1 [Source:HGNC Symbol;Acc:HGNC:4419] GO:0040011|GO:0032502|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0042995|GO:0002683|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0043229|GO:0044702|GO:0042175|GO:0071704|GO:0042698|GO:0003006|GO:0048870|GO:0044297|GO:0051707|GO:0007155|GO:0043227|GO:0009607|GO:0009605|GO:0032504|GO:0005615|GO:0050793|GO:0005622|GO:0002682|GO:0022602|GO:0005789|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0048609|GO:0019222|GO:0045137|GO:0042127|GO:0016337|GO:0098554|GO:0045595|GO:0007530|GO:0070661|GO:0048468|GO:0043025|GO:0010941|GO:0007275|GO:0045596|GO:0048513|GO:0070489|GO:0005102|GO:0030155|GO:0030867|GO:0031982|GO:0044849|GO:0098609|GO:0043231|GO:0048608|GO:0001541|GO:0010243|GO:0005737|GO:0007267|GO:0006928|GO:2000194|GO:0001775|GO:0098562|GO:0043005|GO:0043204|GO:0007548|GO:0036477|GO:0060548|GO:0009617|GO:0007162|GO:0046649|GO:0050865|GO:0008406|GO:0007154|GO:0007565|GO:0051270|GO:0016477|GO:0007165|GO:0005783|GO:0009725|GO:0044306|GO:0008219|GO:0051271|GO:0002695|GO:0008285|GO:0048869|GO:2000145|GO:0010035|GO:0010033|GO:2000146|GO:0005794|GO:0007568|GO:0050768|GO:0051249|GO:0005798|GO:0010468|GO:0032943|GO:0033993|GO:0030424|GO:0008585|GO:0061458|GO:0031410|GO:0002237|GO:0043069|GO:2000354|GO:0005179|GO:0034109|GO:0010721|GO:1901652|GO:0046545|GO:0030238|GO:0010038|GO:0030334|GO:0016023|GO:0001764|GO:0005791|GO:0051250|GO:0043679|GO:0022408|GO:0022407|GO:0043434|GO:0030425|GO:0007159|GO:0031988|GO:0070664|GO:0005739|GO:0098556|GO:0030336|GO:0070542|GO:0042110|GO:0012501|GO:0014070|GO:0010467|GO:0007399|GO:0046651|GO:0030154|GO:0032496|GO:0043067|GO:0048545|GO:0097305|GO:0051960|GO:1903038|GO:0042098|GO:2001222|GO:0050863|GO:1990005|GO:0050868|GO:1990637|GO:0070486|GO:0045471|GO:0035864|GO:0034695|GO:0042981|GO:2001223|GO:0043066|GO:0005183|GO:0034111|GO:0032945|GO:0033574|GO:0022008|GO:0050767|GO:0031960|GO:0050672|GO:0006915|GO:0048699|GO:0042130|GO:0042129|GO:1990008|GO:0071593|GO:0033087 locomotion|developmental process|reproduction|immune system process|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|cell projection|negative regulation of immune system process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|intracellular organelle|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ovulation cycle|developmental process involved in reproduction|cell motility|cell body|response to other organism|cell adhesion|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|multicellular organism reproduction|extracellular space|regulation of developmental process|intracellular|regulation of immune system process|ovulation cycle process|endoplasmic reticulum membrane|protein binding|endomembrane system|anatomical structure development|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|regulation of cell proliferation|single organismal cell-cell adhesion|cytoplasmic side of endoplasmic reticulum membrane|regulation of cell differentiation|sex determination|leukocyte proliferation|cell development|neuronal cell body|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|animal organ development|T cell aggregation|receptor binding|regulation of cell adhesion|rough endoplasmic reticulum membrane|vesicle|estrous cycle|cell-cell adhesion|intracellular membrane-bounded organelle|reproductive structure development|ovarian follicle development|response to organonitrogen compound|cytoplasm|cell-cell signaling|movement of cell or subcellular component|regulation of female gonad development|cell activation|cytoplasmic side of membrane|neuron projection|perikaryon|sex differentiation|somatodendritic compartment|negative regulation of cell death|response to bacterium|negative regulation of cell adhesion|lymphocyte activation|regulation of cell activation|gonad development|cell communication|female pregnancy|regulation of cellular component movement|cell migration|signal transduction|endoplasmic reticulum|response to hormone|neuron projection terminus|cell death|negative regulation of cellular component movement|negative regulation of leukocyte activation|negative regulation of cell proliferation|cellular developmental process|regulation of cell motility|response to inorganic substance|response to organic substance|negative regulation of cell motility|Golgi apparatus|aging|negative regulation of neurogenesis|regulation of lymphocyte activation|Golgi-associated vesicle|regulation of gene expression|mononuclear cell proliferation|response to lipid|axon|female gonad development|reproductive system development|cytoplasmic vesicle|response to molecule of bacterial origin|negative regulation of programmed cell death|regulation of ovarian follicle development|hormone activity|homotypic cell-cell adhesion|negative regulation of cell development|response to peptide|development of primary female sexual characteristics|male sex determination|response to metal ion|regulation of cell migration|cytoplasmic, membrane-bounded vesicle|neuron migration|rough endoplasmic reticulum|negative regulation of lymphocyte activation|axon terminus|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|response to peptide hormone|dendrite|leukocyte cell-cell adhesion|membrane-bounded vesicle|negative regulation of leukocyte proliferation|mitochondrion|cytoplasmic side of rough endoplasmic reticulum membrane|negative regulation of cell migration|response to fatty acid|T cell activation|programmed cell death|response to organic cyclic compound|gene expression|nervous system development|lymphocyte proliferation|cell differentiation|response to lipopolysaccharide|regulation of programmed cell death|response to steroid hormone|response to alcohol|regulation of nervous system development|negative regulation of leukocyte cell-cell adhesion|T cell proliferation|regulation of neuron migration|regulation of T cell activation|granular vesicle|negative regulation of T cell activation|response to prolactin|leukocyte aggregation|response to ethanol|response to potassium ion|response to prostaglandin E|regulation of apoptotic process|negative regulation of neuron migration|negative regulation of apoptotic process|gonadotropin hormone-releasing hormone activity|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|response to testosterone|neurogenesis|regulation of neurogenesis|response to corticosteroid|negative regulation of lymphocyte proliferation|apoptotic process|generation of neurons|negative regulation of T cell proliferation|regulation of T cell proliferation|neurosecretory vesicle|lymphocyte aggregation|negative regulation of immature T cell proliferation K05252 gonadotropin-releasing hormone[-] hsa04912 GnRH signaling pathway - Homo sapiens (human) 8:25419260-25424654 77 81 94 44 31 6 2.55235063745541 2.4401602123067 2.80927993954245 1.30679165721119 0.843113625856979 0.186403462519546 2.60059692976819 0.778769581862572 1.73957437152395 0.000193798725196091 0.00141736088731115 UP ENSG00000128045 RASL11B RAS-like family 11 member B [Source:HGNC Symbol;Acc:HGNC:23804] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0050794|GO:0043167|GO:0023051|GO:0023057|GO:0005622|GO:0005515|GO:0006810|GO:0005102|GO:0043168|GO:0001882|GO:0090287|GO:0071559|GO:0009966|GO:0045184|GO:0010646|GO:0090288|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0000166|GO:0010033|GO:0005126|GO:0090101|GO:0007166|GO:0035639|GO:0001883|GO:0015031|GO:0071560|GO:0032549|GO:0070848|GO:0035556|GO:0071310|GO:0017076|GO:0032561|GO:0071363|GO:0007179|GO:0030512|GO:0007167|GO:0005525|GO:0005160|GO:0007264|GO:0019001|GO:0017015|GO:0007178 signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|ion binding|regulation of signaling|negative regulation of signaling|intracellular|protein binding|transport|receptor binding|anion binding|nucleoside binding|regulation of cellular response to growth factor stimulus|response to transforming growth factor beta|regulation of signal transduction|establishment of protein localization|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|protein localization|cell communication|signal transduction|negative regulation of signal transduction|nucleotide binding|response to organic substance|cytokine receptor binding|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|cellular response to transforming growth factor beta stimulus|ribonucleoside binding|response to growth factor|intracellular signal transduction|cellular response to organic substance|purine nucleotide binding|guanyl ribonucleotide binding|cellular response to growth factor stimulus|transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|GTP binding|transforming growth factor beta receptor binding|small GTPase mediated signal transduction|guanyl nucleotide binding|regulation of transforming growth factor beta receptor signaling pathway|transmembrane receptor protein serine/threonine kinase signaling pathway - - - - 4:52862290-52866835 6 5 6 0 0 1 0.09842332506702 0.074551701079132 0.0887449703108259 0 0 0.0153723899298975 0.0872399988189926 0.0051241299766325 4.08961077436626 0.000194087336417619 0.00141912401210179 UP ENSG00000120262 CCDC170 coiled-coil domain containing 170 [Source:HGNC Symbol;Acc:HGNC:21177] GO:0005488|GO:0005515 binding|protein binding - - - - 6:151494030-151621193 7 5 13 14 44 58 0.0836008899394908 0.0542743432472087 0.139976583113356 0.149811233580227 0.431145991572138 0.649175561229185 0.0926172721000185 0.410044262127183 -2.14642647909254 0.000194384592661554 0.00142060162284407 DOWN ENSG00000279696 RP11-178H8.7 - - - - - - - 11:93726654-93729805 36 92 33 20 1 1 0.807912686558292 1.87640602515051 0.667716478970392 0.402142428275587 0.0184210747412286 0.0210297415538446 1.11734506355973 0.14719774819022 2.92424728770736 0.000194367061769471 0.00142060162284407 UP ENSG00000159251 ACTC1 actin, alpha, cardiac muscle 1 [Source:HGNC Symbol;Acc:HGNC:143] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0042995|GO:0097159|GO:0030055|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0031252|GO:0016787|GO:0005615|GO:0005622|GO:0072562|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0030017|GO:0007507|GO:0009888|GO:0048468|GO:0005884|GO:0010941|GO:0007275|GO:0048513|GO:0043168|GO:0005924|GO:0005912|GO:0001882|GO:0031982|GO:0016817|GO:0022607|GO:0061061|GO:0005737|GO:0003012|GO:0006928|GO:0009887|GO:0048729|GO:0030027|GO:0031674|GO:0060548|GO:0042493|GO:0070062|GO:0008092|GO:0008219|GO:0000166|GO:0048869|GO:0030029|GO:0010033|GO:0003013|GO:0006996|GO:0005829|GO:0010468|GO:0006936|GO:0042643|GO:0035639|GO:0007010|GO:0072358|GO:0042692|GO:0043069|GO:0017022|GO:0035051|GO:0030048|GO:0090131|GO:0048738|GO:0001883|GO:0003007|GO:0055006|GO:0010628|GO:0016818|GO:0060537|GO:0032549|GO:0043292|GO:0060485|GO:0030175|GO:0055001|GO:0030036|GO:0042641|GO:0070925|GO:0012501|GO:0010467|GO:0017076|GO:0060415|GO:0030154|GO:0030239|GO:0007517|GO:0072359|GO:0008015|GO:0005856|GO:0043067|GO:0097305|GO:0005925|GO:0048644|GO:0006941|GO:0055002|GO:0014866|GO:0015629|GO:0055003|GO:0070252|GO:0030016|GO:0055013|GO:0005524|GO:0060047|GO:0030554|GO:0045471|GO:0051146|GO:0030049|GO:0042981|GO:0043066|GO:0031032|GO:0055008|GO:0014706|GO:0055007|GO:0007015|GO:0016462|GO:0006915|GO:0030240|GO:0033275|GO:0017111|GO:0060048|GO:0016887 developmental process|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cell projection|organic cyclic compound binding|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|cell leading edge|hydrolase activity|extracellular space|intracellular|blood microparticle|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|sarcomere|heart development|tissue development|cell development|actin filament|regulation of cell death|multicellular organism development|animal organ development|anion binding|cell-substrate adherens junction|adherens junction|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|cellular component assembly|muscle structure development|cytoplasm|muscle system process|movement of cell or subcellular component|organ morphogenesis|tissue morphogenesis|lamellipodium|I band|negative regulation of cell death|response to drug|extracellular exosome|cytoskeletal protein binding|cell death|nucleotide binding|cellular developmental process|actin filament-based process|response to organic substance|circulatory system process|organelle organization|cytosol|regulation of gene expression|muscle contraction|actomyosin, actin portion|purine ribonucleoside triphosphate binding|cytoskeleton organization|cardiovascular system development|muscle cell differentiation|negative regulation of programmed cell death|myosin binding|cardiocyte differentiation|actin filament-based movement|mesenchyme migration|cardiac muscle tissue development|purine nucleoside binding|heart morphogenesis|cardiac cell development|positive regulation of gene expression|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|muscle tissue development|ribonucleoside binding|contractile fiber|mesenchyme development|filopodium|muscle cell development|actin cytoskeleton organization|actomyosin|organelle assembly|programmed cell death|gene expression|purine nucleotide binding|muscle tissue morphogenesis|cell differentiation|myofibril assembly|muscle organ development|circulatory system development|blood circulation|cytoskeleton|regulation of programmed cell death|response to alcohol|focal adhesion|muscle organ morphogenesis|striated muscle contraction|striated muscle cell development|skeletal myofibril assembly|actin cytoskeleton|cardiac myofibril assembly|actin-mediated cell contraction|myofibril|cardiac muscle cell development|ATP binding|heart contraction|adenyl nucleotide binding|response to ethanol|striated muscle cell differentiation|muscle filament sliding|regulation of apoptotic process|negative regulation of apoptotic process|actomyosin structure organization|cardiac muscle tissue morphogenesis|striated muscle tissue development|cardiac muscle cell differentiation|actin filament organization|pyrophosphatase activity|apoptotic process|skeletal muscle thin filament assembly|actin-myosin filament sliding|nucleoside-triphosphatase activity|cardiac muscle contraction|ATPase activity K12314 actin, alpha cardiac muscle[-] hsa04261|hsa05414|hsa05410|hsa04260 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human) 15:34788096-34796139 10 5 2 0 0 0 0.139129746160828 0.0632311044557863 0.0250897136100368 0 0 0 0.075816854742217 0 Inf 0.000196088028641571 0.00143199902325476 UP ENSG00000110318 CEP126 centrosomal protein 126kDa [Source:HGNC Symbol;Acc:HGNC:29264] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0030496|GO:0042995|GO:0043229|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0007049|GO:0022402|GO:0022607|GO:0005737|GO:0097546|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0005813|GO:1903047|GO:0007010|GO:0005815|GO:0044782|GO:0000278|GO:0030031|GO:0007051|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0000226|GO:0005856|GO:0060271|GO:0035058|GO:0031122|GO:0007052|GO:0015630 developmental process|cell|cellular process|binding|midbody|cell projection|intracellular organelle|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|cell cycle|cell cycle process|cellular component assembly|cytoplasm|ciliary base|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|centrosome|mitotic cell cycle process|cytoskeleton organization|microtubule organizing center|cilium organization|mitotic cell cycle|cell projection assembly|spindle organization|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|cilium morphogenesis|nonmotile primary cilium assembly|cytoplasmic microtubule organization|mitotic spindle organization|microtubule cytoskeleton - - - - 11:101915015-102001058 176 188 323 438 428 660 1.36106957772134 1.32130893089156 2.25207646593765 3.03485860594872 2.71567825041546 4.78343634588666 1.64481832485018 3.51132440075028 -1.09408704591481 0.000198199716646854 0.00144706635871245 DOWN ENSG00000251169 AC005355.2 - - - - - - - 5:134506552-134509229 8 10 11 36 28 30 0.511172993302006 0.580734436125289 0.633717432508563 2.06110801773623 1.46799721424993 1.79661646642561 0.575208287311953 1.77524056613726 -1.62585817347738 0.000199370430227587 0.00145490218137726 DOWN ENSG00000248265 FLJ12825 uncharacterized LOC440101 [Source:EntrezGene;Acc:440101] - - - - - - 12:54058254-54122234 4 0 2 9 18 14 0.0717742901554186 0 0.0323582201911281 0.144697010237313 0.265010940062628 0.235449383254403 0.0347108367821822 0.215052444518115 -2.63123048052226 0.000200502579321014 0.00146244906011472 DOWN ENSG00000270878 CTD-2302E22.5 - - - - - - - 14:63594031-63595291 34 30 13 4 5 11 1.90727491049596 1.52943621123877 0.657479224250917 0.201049492805185 0.230134730550274 0.578282090329342 1.36473011532855 0.336488771228267 2.01998540917385 0.000203811388619006 0.00148301687124978 UP ENSG00000141337 ARSG arylsulfatase G [Source:HGNC Symbol;Acc:HGNC:24102] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005615|GO:0005622|GO:0012505|GO:0044255|GO:0016788|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0006629|GO:0005783|GO:0019538|GO:0006790|GO:0006665|GO:0046872|GO:0043412|GO:0008484|GO:0005773|GO:0006643|GO:0036211|GO:0044267|GO:0005788|GO:0006687|GO:0000323|GO:0004065|GO:0006664|GO:0006464|GO:0005764|GO:0043687 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|extracellular space|intracellular|endomembrane system|cellular lipid metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|lipid metabolic process|endoplasmic reticulum|protein metabolic process|sulfur compound metabolic process|sphingolipid metabolic process|metal ion binding|macromolecule modification|sulfuric ester hydrolase activity|vacuole|membrane lipid metabolic process|protein modification process|cellular protein metabolic process|endoplasmic reticulum lumen|glycosphingolipid metabolic process|lytic vacuole|arylsulfatase activity|glycolipid metabolic process|cellular protein modification process|lysosome|post-translational protein modification K12381 arylsulfatase G [EC:3.1.6.-][-] hsa04142 Lysosome - Homo sapiens (human) 17:68259182-68422731 22 20 26 56 51 84 0.156276827255325 0.129116895117633 0.166515625985219 0.35641690194403 0.297243014372911 0.559219499822488 0.150636449452726 0.404293138713143 -1.4243308190386 0.000204196732672806 0.00148476783340615 DOWN ENSG00000164066 INTU inturned planar cell polarity protein [Source:HGNC Symbol;Acc:HGNC:29239] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0009986|GO:0023051|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0042127|GO:0009888|GO:0035295|GO:0007275|GO:0048513|GO:0051302|GO:0031069|GO:0022607|GO:0001942|GO:0005737|GO:0007389|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0050673|GO:0051782|GO:0010646|GO:0007154|GO:0007165|GO:0030278|GO:0001503|GO:0008285|GO:0030030|GO:0051301|GO:0048869|GO:0009967|GO:0006996|GO:0000902|GO:0042733|GO:0007166|GO:0002009|GO:0007417|GO:0022405|GO:0021510|GO:0045880|GO:0008589|GO:0009790|GO:0044782|GO:0003002|GO:0030031|GO:0050678|GO:0050680|GO:0043588|GO:0070925|GO:0060429|GO:0042384|GO:0035108|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0060173|GO:0043616|GO:0042633|GO:0060271|GO:0010837|GO:1903887|GO:0009792|GO:0030855|GO:0030216|GO:0007224|GO:0008544|GO:0009953|GO:0048730|GO:0021511|GO:0030326|GO:0010839|GO:0098773|GO:0021513|GO:0043009|GO:0009913 developmental process|signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|cell surface|regulation of signaling|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of cell proliferation|tissue development|tube development|multicellular organism development|animal organ development|regulation of cell division|hair follicle morphogenesis|cellular component assembly|hair follicle development|cytoplasm|pattern specification process|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|epithelial cell proliferation|negative regulation of cell division|regulation of cell communication|cell communication|signal transduction|regulation of ossification|ossification|negative regulation of cell proliferation|cell projection organization|cell division|cellular developmental process|positive regulation of signal transduction|organelle organization|cell morphogenesis|embryonic digit morphogenesis|cell surface receptor signaling pathway|morphogenesis of an epithelium|central nervous system development|hair cycle process|spinal cord development|positive regulation of smoothened signaling pathway|regulation of smoothened signaling pathway|embryo development|cilium organization|regionalization|cell projection assembly|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|skin development|organelle assembly|epithelium development|cilium assembly|limb morphogenesis|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|limb development|keratinocyte proliferation|hair cycle|cilium morphogenesis|regulation of keratinocyte proliferation|motile primary cilium assembly|embryo development ending in birth or egg hatching|epithelial cell differentiation|keratinocyte differentiation|smoothened signaling pathway|epidermis development|dorsal/ventral pattern formation|epidermis morphogenesis|spinal cord patterning|embryonic limb morphogenesis|negative regulation of keratinocyte proliferation|skin epidermis development|spinal cord dorsal/ventral patterning|chordate embryonic development|epidermal cell differentiation - - - - 4:127623271-127726737 78 93 196 264 317 291 0.287953810017873 0.312027008924969 0.652375369218055 0.873230417217053 0.960183733596152 1.00681329129114 0.417452062720299 0.946742480701448 -1.18136151978576 0.000205803568699912 0.00149563284809327 DOWN ENSG00000160111 CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 [Source:HGNC Symbol;Acc:HGNC:23228] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0071704|GO:0044237|GO:0071944|GO:0005615|GO:0030234|GO:0005515|GO:0005886|GO:0019222|GO:0004857|GO:0044092|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0030414|GO:0032269|GO:0051346|GO:0006508|GO:0044267|GO:0051246|GO:0004866|GO:0010466|GO:0030162|GO:0052547|GO:0045861|GO:0010951|GO:0004867|GO:0052548 cell|membrane|cellular process|extracellular region|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|cellular metabolic process|cell periphery|extracellular space|enzyme regulator activity|protein binding|plasma membrane|regulation of metabolic process|enzyme inhibitor activity|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|peptidase inhibitor activity|negative regulation of cellular protein metabolic process|negative regulation of hydrolase activity|proteolysis|cellular protein metabolic process|regulation of protein metabolic process|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of proteolysis|regulation of peptidase activity|negative regulation of proteolysis|negative regulation of endopeptidase activity|serine-type endopeptidase inhibitor activity|regulation of endopeptidase activity - - - - 19:16892947-17026815 55 74 201 244 266 566 0.192513811396968 0.235403055759866 0.634325700615943 0.7652241620254 0.763923726176972 1.8567201002556 0.354080855924259 1.12862266281932 -1.67241247558575 0.000206840817961917 0.0015028050083804 DOWN ENSG00000178397 FAM220A family with sequence similarity 220 member A [Source:HGNC Symbol;Acc:HGNC:22422] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - 7:6329409-6348981 259 672 750 355 147 124 3.11366775415295 7.34213593583454 8.12920985363938 3.82383842895782 1.44997158564191 1.39709214447537 6.19500451454229 2.22363405302503 1.47818595272441 0.000210388251903611 0.00152741664742383 UP ENSG00000234147 RP3-460G2.2 - - - - - - - 6:140845958-140852924 8 12 17 36 33 45 1.24915784455921 1.70297488951177 2.39336315621912 5.03674740758058 4.22797530110059 6.58545502372919 1.78183196343003 5.28339257747012 -1.56810332277378 0.000210432929284325 0.00152741664742383 DOWN ENSG00000115282 TTC31 tetratricopeptide repeat domain 31 [Source:HGNC Symbol;Acc:HGNC:25759] GO:0005488|GO:0005515 binding|protein binding - - - - 2:74483073-74494886 124 159 103 255 296 331 0.4802540172616 0.559664446738388 0.359667788259809 0.884886794236775 0.940608619815203 1.20145268688624 0.466528750753266 1.00898270031274 -1.11286354082598 0.000211894630973054 0.00153690532387501 DOWN ENSG00000214534 ZNF705E zinc finger protein 705E [Source:HGNC Symbol;Acc:HGNC:33203] - - - - - - 11:71814045-71821548 4 6 0 15 19 17 0.0652824761865852 0.0889994952640556 0 0.219354113981656 0.254438475614036 0.260036618579144 0.0514273238168803 0.244609736058279 -2.24987484218899 0.000212304681051346 0.00153950545253992 DOWN ENSG00000261168 RP11-68I18.10 - - - - - - - 1:151130075-151131610 7 6 11 0 2 1 0.322375046296617 0.251122273746365 0.456722133975898 0 0.0755653214972472 0.0431547821469519 0.34340648467296 0.0395733678813997 3.11731552670444 0.00021376044212907 0.00154855720439729 UP ENSG00000165061 ZMAT4 zinc finger, matrin-type 4 [Source:HGNC Symbol;Acc:HGNC:25844] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0003676|GO:0002039|GO:0043231|GO:0043169|GO:0007154|GO:0007165|GO:0008219|GO:0003677|GO:0046872|GO:0003723|GO:0012501|GO:0035556|GO:0005634|GO:0097190|GO:0097193|GO:0072331|GO:0046914|GO:0006915|GO:0072332|GO:0008270 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|nucleic acid binding|p53 binding|intracellular membrane-bounded organelle|cation binding|cell communication|signal transduction|cell death|DNA binding|metal ion binding|RNA binding|programmed cell death|intracellular signal transduction|nucleus|apoptotic signaling pathway|intrinsic apoptotic signaling pathway|signal transduction by p53 class mediator|transition metal ion binding|apoptotic process|intrinsic apoptotic signaling pathway by p53 class mediator|zinc ion binding - - - - 8:40530590-40897833 1 8 9 22 24 23 0.0104007485923889 0.0755876567655138 0.0843575975593111 0.20492572591686 0.204723140584234 0.224101072007455 0.0567820009724046 0.21124997950285 -1.89544560641217 0.000214941248937975 0.0015556014656471 DOWN ENSG00000146411 SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 [Source:HGNC Symbol;Acc:HGNC:18067] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0006810|GO:0005887|GO:0005737|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0006811|GO:0015075|GO:0051119|GO:0048471|GO:0034219|GO:0008643|GO:0015293|GO:0015992|GO:0006812|GO:0035428|GO:0008324|GO:0015149|GO:0008645|GO:1904659|GO:0005351|GO:0015672|GO:0005355|GO:0015295|GO:0015758|GO:0046323 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|transport|integral component of plasma membrane|cytoplasm|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|ion transport|ion transmembrane transporter activity|sugar transmembrane transporter activity|perinuclear region of cytoplasm|carbohydrate transmembrane transport|carbohydrate transport|symporter activity|proton transport|cation transport|hexose transmembrane transport|cation transmembrane transporter activity|hexose transmembrane transporter activity|hexose transport|glucose transmembrane transport|sugar:proton symporter activity|monovalent inorganic cation transport|glucose transmembrane transporter activity|solute:proton symporter activity|glucose transport|glucose import - - - - 6:133988697-134052636 56 63 98 141 152 287 0.886588699181722 0.906475034834209 1.39886204095131 2.00009214091528 1.97443477703491 4.25837208883589 1.06397525832241 2.74429966892869 -1.36697342508976 0.000215983588403598 0.00156125279617458 DOWN ENSG00000011021 CLCN6 chloride channel, voltage-sensitive 6 [Source:HGNC Symbol;Acc:HGNC:2024] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0022857|GO:0050794|GO:0043229|GO:0043167|GO:0009628|GO:0016043|GO:0043227|GO:0009605|GO:0031224|GO:0005622|GO:0012505|GO:0031090|GO:0006810|GO:0009612|GO:0032535|GO:0043168|GO:0001882|GO:0043231|GO:0005774|GO:0005737|GO:0042592|GO:0019725|GO:0022891|GO:0007154|GO:0055085|GO:0007165|GO:0010008|GO:0000166|GO:0016021|GO:0005768|GO:0006884|GO:0035639|GO:0001883|GO:0005773|GO:0015267|GO:0006811|GO:0032549|GO:0015075|GO:0008361|GO:0034765|GO:0043269|GO:0017076|GO:0034220|GO:0006820|GO:0005216|GO:0098656|GO:0000323|GO:0005524|GO:0015297|GO:0008509|GO:0030554|GO:0044070|GO:1903959|GO:0005765|GO:0005244|GO:0005253|GO:0005764|GO:0015698|GO:0005254|GO:0008308|GO:0006821|GO:0015108|GO:0005247 transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|transmembrane transporter activity|regulation of cellular process|intracellular organelle|ion binding|response to abiotic stimulus|cellular component organization|membrane-bounded organelle|response to external stimulus|intrinsic component of membrane|intracellular|endomembrane system|organelle membrane|transport|response to mechanical stimulus|regulation of cellular component size|anion binding|nucleoside binding|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|cell communication|transmembrane transport|signal transduction|endosome membrane|nucleotide binding|integral component of membrane|endosome|cell volume homeostasis|purine ribonucleoside triphosphate binding|purine nucleoside binding|vacuole|channel activity|ion transport|ribonucleoside binding|ion transmembrane transporter activity|regulation of cell size|regulation of ion transmembrane transport|regulation of ion transport|purine nucleotide binding|ion transmembrane transport|anion transport|ion channel activity|anion transmembrane transport|lytic vacuole|ATP binding|antiporter activity|anion transmembrane transporter activity|adenyl nucleotide binding|regulation of anion transport|regulation of anion transmembrane transport|lysosomal membrane|voltage-gated ion channel activity|anion channel activity|lysosome|inorganic anion transport|chloride channel activity|voltage-gated anion channel activity|chloride transport|chloride transmembrane transporter activity|voltage-gated chloride channel activity - - - - 1:11806096-11843144 94 65 114 194 209 218 0.605691949523775 0.380643565293987 0.662278892563684 1.12001281621913 1.10493565710746 1.31646255491465 0.549538135793815 1.18047034274708 -1.10307028968669 0.000216884083010788 0.00156700324641919 DOWN ENSG00000126091 ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:10866] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0044255|GO:0031228|GO:0006082|GO:0034641|GO:0044281|GO:0043231|GO:0005737|GO:0005975|GO:0006629|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0005794|GO:0006790|GO:0009311|GO:0006490|GO:0034645|GO:0006665|GO:0043412|GO:0006487|GO:0006643|GO:0030173|GO:0006493|GO:0009100|GO:0036211|GO:0008373|GO:0070085|GO:0043603|GO:0005795|GO:1901137|GO:0044267|GO:0042339|GO:0008610|GO:0000139|GO:0009059|GO:0009101|GO:0006672|GO:0043413|GO:0003836|GO:0006687|GO:0006488|GO:0009247|GO:0018279|GO:0097503|GO:0031985|GO:0008118|GO:0006664|GO:0032580|GO:0006024|GO:0030203|GO:0018146|GO:0030148|GO:0006464|GO:0016266|GO:0046513|GO:0006688|GO:0018193|GO:0043687|GO:0001573|GO:0001574 cell|membrane|cellular process|extracellular region|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|cellular lipid metabolic process|intrinsic component of Golgi membrane|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|lipid metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|Golgi apparatus|sulfur compound metabolic process|oligosaccharide metabolic process|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|sphingolipid metabolic process|macromolecule modification|protein N-linked glycosylation|membrane lipid metabolic process|integral component of Golgi membrane|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|sialyltransferase activity|glycosylation|cellular amide metabolic process|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|keratan sulfate metabolic process|lipid biosynthetic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|ceramide metabolic process|macromolecule glycosylation|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|glycosphingolipid metabolic process|dolichol-linked oligosaccharide biosynthetic process|glycolipid biosynthetic process|protein N-linked glycosylation via asparagine|sialylation|Golgi cisterna|N-acetyllactosaminide alpha-2,3-sialyltransferase activity|glycolipid metabolic process|Golgi cisterna membrane|glycosaminoglycan biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate biosynthetic process|sphingolipid biosynthetic process|cellular protein modification process|O-glycan processing|ceramide biosynthetic process|glycosphingolipid biosynthetic process|peptidyl-amino acid modification|post-translational protein modification|ganglioside metabolic process|ganglioside biosynthetic process K00781 N-acetyllactosaminide alpha-2,3-sialyltransferase (sialyltransferase 6)[2.4.99.6] hsa01100|hsa00514|hsa00601|hsa00533 Metabolic pathways - Homo sapiens (human)|Other types of O-glycan biosynthesis - Homo sapiens (human)|Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human)|Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human) 1:43705824-43931165 12 16 27 44 46 81 0.100923673323847 0.122291859857937 0.204728811049149 0.331553132384815 0.317411252158072 0.638431880049838 0.142648114743644 0.429132088197575 -1.5889611019255 0.000218117043629282 0.00157445411478346 DOWN ENSG00000198915 RASGEF1A RasGEF domain family member 1A [Source:HGNC Symbol;Acc:HGNC:24246] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0009605|GO:0009893|GO:0005622|GO:0002682|GO:0005085|GO:0048856|GO:0019222|GO:0006935|GO:0045087|GO:0048468|GO:0007275|GO:0006952|GO:0031325|GO:0010243|GO:0005737|GO:0005088|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0016477|GO:0007165|GO:0009725|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007166|GO:0043412|GO:0051345|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:1901653|GO:0043408|GO:0071363|GO:0043087|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0043547|GO:0007167|GO:0071375|GO:0043410|GO:0032868|GO:0051057|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0046579|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0042327|GO:0007169|GO:0048010|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|response to external stimulus|positive regulation of metabolic process|intracellular|regulation of immune system process|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|chemotaxis|innate immune response|cell development|multicellular organism development|defense response|positive regulation of cellular metabolic process|response to organonitrogen compound|cytoplasm|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|cell migration|signal transduction|response to hormone|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|cell surface receptor signaling pathway|macromolecule modification|positive regulation of hydrolase activity|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|cellular response to peptide|regulation of MAPK cascade|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|response to insulin|positive regulation of small GTPase mediated signal transduction|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|positive regulation of Ras protein signal transduction|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 10:43194535-43266919 93 94 174 208 295 353 0.809863292927415 0.743937756424047 1.36613493216954 1.62289406804596 2.10775215143044 2.88093436191695 0.973311993840334 2.20386019379778 -1.17905846842267 0.000218126288562484 0.00157445411478346 DOWN ENSG00000055813 CCDC85A coiled-coil domain containing 85A [Source:HGNC Symbol;Acc:HGNC:29400] - - - - - - 2:56184123-56386173 0 0 0 6 4 5 0 0 0 0.0955010335612778 0.0582965011651289 0.0832494333598675 0 0.0790156560287581 -Inf 0.000218583759445545 0.00157699360910761 DOWN ENSG00000242247 ARFGAP3 ADP ribosylation factor GTPase activating protein 3 [Source:HGNC Symbol;Acc:HGNC:661] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0043167|GO:0051641|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0019222|GO:0008565|GO:0006810|GO:0008047|GO:0032940|GO:0043231|GO:0043169|GO:0005737|GO:0045184|GO:0043085|GO:0008104|GO:0051649|GO:0050790|GO:0005794|GO:0016192|GO:0005829|GO:0005096|GO:0046872|GO:0051345|GO:0030695|GO:0015031|GO:0046907|GO:0009306|GO:0034613|GO:0046903|GO:0000139|GO:0043087|GO:0006886|GO:0043547 transporter activity|cell|membrane|cellular process|metabolic process|binding|intracellular organelle|ion binding|cellular localization|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|endomembrane system|organelle membrane|regulation of metabolic process|protein transporter activity|transport|enzyme activator activity|secretion by cell|intracellular membrane-bounded organelle|cation binding|cytoplasm|establishment of protein localization|positive regulation of catalytic activity|protein localization|establishment of localization in cell|regulation of catalytic activity|Golgi apparatus|vesicle-mediated transport|cytosol|GTPase activator activity|metal ion binding|positive regulation of hydrolase activity|GTPase regulator activity|protein transport|intracellular transport|protein secretion|cellular protein localization|secretion|Golgi membrane|regulation of GTPase activity|intracellular protein transport|positive regulation of GTPase activity K12493 ADP-ribosylation factor GTPase-activating protein 2/3[-] hsa04144 Endocytosis - Homo sapiens (human) 22:42796502-42858106 360 406 831 957 1080 1374 5.77051333750727 5.91450385076319 12.0095610396595 13.7442683483031 14.2037618949689 20.640842479617 7.89819274264332 16.1962909076297 -1.03606898116022 0.000219833820299038 0.001585629106356 DOWN ENSG00000139354 GAS2L3 growth arrest specific 2 like 3 [Source:HGNC Symbol;Acc:HGNC:27475] GO:0005623|GO:0009987|GO:0005488|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0016043|GO:0005622|GO:0005515|GO:0051726|GO:0007049|GO:0022402|GO:0005874|GO:0045786|GO:0005737|GO:0032403|GO:0008092|GO:0030029|GO:0007017|GO:0006996|GO:0015631|GO:0007010|GO:0003779|GO:0007050|GO:0008017|GO:0030036|GO:0000226|GO:0005856|GO:0015629|GO:0015630 cell|cellular process|binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|cellular component organization|intracellular|protein binding|regulation of cell cycle|cell cycle|cell cycle process|microtubule|negative regulation of cell cycle|cytoplasm|protein complex binding|cytoskeletal protein binding|actin filament-based process|microtubule-based process|organelle organization|tubulin binding|cytoskeleton organization|actin binding|cell cycle arrest|microtubule binding|actin cytoskeleton organization|microtubule cytoskeleton organization|cytoskeleton|actin cytoskeleton|microtubule cytoskeleton - - - - 12:100573683-100628286 69 49 136 176 225 268 0.380276412679745 0.245431104521408 0.675778326956901 0.869080276550887 1.01742021313851 1.38424902978117 0.433828614719351 1.09024983982352 -1.32946165908544 0.000221995015706137 0.00159889968610157 DOWN ENSG00000172458 IL17D interleukin 17D [Source:HGNC Symbol;Acc:HGNC:5984] GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0005615|GO:0005515|GO:0005102|GO:0006952|GO:0007154|GO:0007165|GO:0005126|GO:0007166|GO:0005125|GO:0006954 signaling|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|extracellular space|protein binding|receptor binding|defense response|cell communication|signal transduction|cytokine receptor binding|cell surface receptor signaling pathway|cytokine activity|inflammatory response K05492 interleukin 17D[-] hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) 13:20702127-20723098 29 25 11 8 4 5 0.557286801662628 0.436624008865691 0.190580059165167 0.137747030930366 0.0630634793913456 0.090056844237705 0.394830289897829 0.0969557848531389 2.02583378798072 0.000222162394854105 0.00159971928026398 UP ENSG00000250742 RP11-834C11.4 - - - - - - - 12:54126098-54142493 3 3 6 14 16 28 0.0783150624793151 0.0711779818801027 0.141206019180916 0.327428758854497 0.34265859479967 0.684949232777606 0.0968996878467779 0.451678862143924 -2.22073347625578 0.000222400322308826 0.00160066037179549 DOWN ENSG00000152284 TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) [Source:HGNC Symbol;Acc:HGNC:11640] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0016043|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:0008013|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005667|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0044249|GO:0031323|GO:0006996|GO:0051276|GO:0030111|GO:0003677|GO:0010468|GO:0034645|GO:0007166|GO:0051252|GO:0006325|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0016055|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0060070 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|beta-catenin binding|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor complex|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|cellular biosynthetic process|regulation of cellular metabolic process|organelle organization|chromosome organization|regulation of Wnt signaling pathway|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|regulation of RNA metabolic process|chromatin organization|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|Wnt signaling pathway|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|canonical Wnt signaling pathway K04490 transcription factor 7-like 1[-] hsa05200|hsa04390|hsa04310|hsa04916|hsa05215|hsa04520|hsa05412|hsa05210|hsa05221|hsa05217|hsa05213|hsa05216 Pathways in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)|Colorectal cancer - Homo sapiens (human)|Acute myeloid leukemia - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Thyroid cancer - Homo sapiens (human) 2:85133410-85310388 75 62 125 183 205 217 1.12997851638627 0.848948398062259 1.69798144416424 2.47034701995154 2.53415271056147 3.06407671618217 1.22563611953759 2.68952548223173 -1.13382093870609 0.00022473135793711 0.00161587908474337 DOWN ENSG00000262769 RP11-1113L8.1 - - - - - - - 17:19560111-19597922 0 4 2 10 9 25 0 0.352259189474353 0.174734389032092 0.868230857627873 0.715529538169095 2.27034956807419 0.175664526168815 1.28470332129039 -2.87054044696606 0.000226010408108657 0.00162468449883839 DOWN ENSG00000253943 KRT18P37 keratin 18 pseudogene 37 [Source:HGNC Symbol;Acc:HGNC:33406] - - - - - - 8:41511240-41512521 7 4 3 0 0 0 0.386246545328864 0.200584405862931 0.149220578637497 0 0 0 0.245350509943097 0 Inf 0.000227010800130135 0.00163148301085341 UP ENSG00000196312 HIATL2 major facilitator superfamily domain containing 14C [Source:HGNC Symbol;Acc:HGNC:23672] GO:0005215|GO:0016020|GO:0009987|GO:0031224|GO:0006810|GO:0055085|GO:0016021 transporter activity|membrane|cellular process|intrinsic component of membrane|transport|transmembrane transport|integral component of membrane - - - - 9:96898066-97013580 78 91 119 186 203 226 4.10527005487535 4.35280871566458 5.64689086065816 8.7711710383921 8.76616110187308 11.1476803628163 4.7016565437327 9.56167083436049 -1.02409358710246 0.000227192211766805 0.00163239381229511 DOWN ENSG00000259439 RP11-89K21.1 - - - - - - - 2:44921077-44939199 46 50 42 101 110 114 0.617433855315633 0.609936452363088 0.508275414707444 1.21465686898447 1.21142757701687 1.43405914436719 0.578548574128722 1.28671453012284 -1.1531820172324 0.00022902571603488 0.00164398502681061 DOWN ENSG00000205755 CRLF2 cytokine receptor-like factor 2 [Source:HGNC Symbol;Acc:HGNC:14281] GO:0005623|GO:0016020|GO:0005576|GO:0005488|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0016021 cell|membrane|extracellular region|binding|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|integral component of membrane K05078 thymic stromal-derived lymphopoietin receptor[-] hsa04060|hsa04630 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human) X:1187549-1212750 3 6 5 21 19 18 0.0525851881365074 0.0955708157766147 0.0790031927172197 0.329773499910185 0.273225062762941 0.295660171035612 0.0757197322101139 0.299552911236246 -1.98406964061569 0.000229579092842802 0.00164756111483871 DOWN ENSG00000139437 TCHP trichoplein, keratin filament binding [Source:HGNC Symbol;Acc:HGNC:28135] GO:0032502|GO:0040007|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0042995|GO:0048523|GO:0050794|GO:0043229|GO:0016049|GO:0045177|GO:0045926|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0040008|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:1902115|GO:0045179|GO:0005938|GO:0051128|GO:0022607|GO:0005882|GO:0043231|GO:0030308|GO:0005737|GO:0060491|GO:0030057|GO:0008219|GO:1902018|GO:0030030|GO:0048869|GO:0097539|GO:0001558|GO:0006996|GO:0000902|GO:0005813|GO:0031344|GO:0005815|GO:1902017|GO:0044782|GO:0031345|GO:0030031|GO:0022604|GO:0005739|GO:0045095|GO:0070925|GO:0012501|GO:0042384|GO:0033043|GO:0032990|GO:0048858|GO:0005856|GO:0060271|GO:0015630|GO:0045111|GO:0006915 developmental process|growth|macromolecular complex|cell|membrane|cellular process|cell junction|binding|cell projection|negative regulation of cellular process|regulation of cellular process|intracellular organelle|cell growth|apical part of cell|negative regulation of growth|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|regulation of growth|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of organelle assembly|apical cortex|cell cortex|regulation of cellular component organization|cellular component assembly|intermediate filament|intracellular membrane-bounded organelle|negative regulation of cell growth|cytoplasm|regulation of cell projection assembly|desmosome|cell death|negative regulation of cilium assembly|cell projection organization|cellular developmental process|ciliary transition fiber|regulation of cell growth|organelle organization|cell morphogenesis|centrosome|regulation of cell projection organization|microtubule organizing center|regulation of cilium assembly|cilium organization|negative regulation of cell projection organization|cell projection assembly|regulation of cell morphogenesis|mitochondrion|keratin filament|organelle assembly|programmed cell death|cilium assembly|regulation of organelle organization|cell part morphogenesis|cell projection morphogenesis|cytoskeleton|cilium morphogenesis|microtubule cytoskeleton|intermediate filament cytoskeleton|apoptotic process - - - - 12:109900264-109983841 119 130 112 319 281 210 0.618263564160894 0.613833953013517 0.524637648077172 1.48496648845786 1.19785047873537 1.0225317258965 0.585578388417194 1.23511623102991 -1.07671259844722 0.000230036484408039 0.00165044681699534 DOWN ENSG00000119915 ELOVL3 ELOVL fatty acid elongase 3 [Source:HGNC Symbol;Acc:HGNC:18047] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0044255|GO:0006082|GO:0044281|GO:0043231|GO:0005737|GO:0051186|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0006790|GO:0046486|GO:0006637|GO:0006631|GO:0006638|GO:0008610|GO:0033559|GO:0001676|GO:0009108|GO:0000038|GO:0006633|GO:0019752|GO:0006639|GO:0006636|GO:0042761|GO:0036109|GO:0043651|GO:0046949|GO:0032787|GO:0030497|GO:0035336|GO:0006641|GO:0019432|GO:0019367|GO:0035338|GO:0034625|GO:0034626 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|cofactor metabolic process|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|sulfur compound metabolic process|glycerolipid metabolic process|acyl-CoA metabolic process|fatty acid metabolic process|neutral lipid metabolic process|lipid biosynthetic process|unsaturated fatty acid metabolic process|long-chain fatty acid metabolic process|coenzyme biosynthetic process|very long-chain fatty acid metabolic process|fatty acid biosynthetic process|carboxylic acid metabolic process|acylglycerol metabolic process|unsaturated fatty acid biosynthetic process|very long-chain fatty acid biosynthetic process|alpha-linolenic acid metabolic process|linoleic acid metabolic process|fatty-acyl-CoA biosynthetic process|monocarboxylic acid metabolic process|fatty acid elongation|long-chain fatty-acyl-CoA metabolic process|triglyceride metabolic process|triglyceride biosynthetic process|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid K10248 elongation of very long chain fatty acids protein 3[2.3.1.199] hsa00062 Fatty acid elongation - Homo sapiens (human) 10:102226328-102229589 61 86 171 25 34 59 3.14732257706726 4.03260975842449 7.9545926505078 1.15571791106116 1.43929826231509 2.85291947085206 5.04484166199985 1.8159785480761 1.4740618290879 0.000230415252200844 0.00165237015114197 UP ENSG00000167807 CTD-2369P2.10 - GO:0009055|GO:0005488|GO:0043167|GO:0051536|GO:0043169|GO:0046872|GO:0051537 electron carrier activity|binding|ion binding|iron-sulfur cluster binding|cation binding|metal ion binding|2 iron, 2 sulfur cluster binding - - - - 19:10305427-10316009 35 9 0 0 0 1 0.972417162061714 0.227264785298309 0 0 0 0.026035249559198 0.399893982453341 0.00867841651973267 5.52604193179984 0.000230547210881117 0.00165291941249877 UP ENSG00000143858 SYT2 synaptotagmin 2 [Source:HGNC Symbol;Acc:HGNC:11510] GO:0032502|GO:0040007|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0036094|GO:0030672|GO:0008021|GO:0050794|GO:0043229|GO:0016049|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0045927|GO:0043227|GO:0008289|GO:0071944|GO:0040008|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0045595|GO:0051640|GO:0048468|GO:0006810|GO:0051130|GO:0007275|GO:0043168|GO:0030307|GO:0032940|GO:0005543|GO:0031982|GO:0051128|GO:0030276|GO:0030141|GO:0045597|GO:0043231|GO:0043178|GO:0043169|GO:0030133|GO:0005737|GO:0007267|GO:0012506|GO:0051656|GO:0048639|GO:0030658|GO:0000149|GO:0007154|GO:0048588|GO:0048638|GO:0051649|GO:0030667|GO:0001505|GO:0030030|GO:0048869|GO:0016021|GO:0001558|GO:0060560|GO:0016192|GO:0006836|GO:0051650|GO:0000902|GO:0031175|GO:0031344|GO:0046872|GO:0042583|GO:0043533|GO:0031410|GO:0010720|GO:0048489|GO:0031346|GO:0042584|GO:0016023|GO:0070382|GO:0046907|GO:0050769|GO:0031988|GO:0022604|GO:0005544|GO:0030659|GO:0032990|GO:0007399|GO:0046903|GO:0051648|GO:0030154|GO:0048858|GO:1903861|GO:0019905|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0005509|GO:0016482|GO:0097484|GO:0036465|GO:0006897|GO:0022008|GO:0050767|GO:0048812|GO:0010976|GO:0045666|GO:0048488|GO:0048699|GO:0006898|GO:0045664|GO:0007268|GO:0072583 developmental process|growth|synapse|signaling|cell|membrane|cellular process|cell junction|binding|small molecule binding|synaptic vesicle membrane|synaptic vesicle|regulation of cellular process|intracellular organelle|cell growth|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|membrane-bounded organelle|lipid binding|cell periphery|regulation of growth|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|neurotransmitter secretion|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of cell differentiation|organelle localization|cell development|transport|positive regulation of cellular component organization|multicellular organism development|anion binding|positive regulation of cell growth|secretion by cell|phospholipid binding|vesicle|regulation of cellular component organization|clathrin binding|secretory granule|positive regulation of cell differentiation|intracellular membrane-bounded organelle|alcohol binding|cation binding|transport vesicle|cytoplasm|cell-cell signaling|vesicle membrane|establishment of organelle localization|positive regulation of developmental growth|transport vesicle membrane|SNARE binding|cell communication|developmental cell growth|regulation of developmental growth|establishment of localization in cell|secretory granule membrane|regulation of neurotransmitter levels|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell growth|developmental growth involved in morphogenesis|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|cell morphogenesis|neuron projection development|regulation of cell projection organization|metal ion binding|chromaffin granule|inositol 1,3,4,5 tetrakisphosphate binding|cytoplasmic vesicle|positive regulation of cell development|synaptic vesicle transport|positive regulation of cell projection organization|chromaffin granule membrane|cytoplasmic, membrane-bounded vesicle|exocytic vesicle|intracellular transport|positive regulation of neurogenesis|membrane-bounded vesicle|regulation of cell morphogenesis|calcium-dependent phospholipid binding|cytoplasmic vesicle membrane|cell part morphogenesis|nervous system development|secretion|vesicle localization|cell differentiation|cell projection morphogenesis|positive regulation of dendrite extension|syntaxin binding|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|calcium ion binding|cytosolic transport|dendrite extension|synaptic vesicle recycling|endocytosis|neurogenesis|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|positive regulation of neuron differentiation|synaptic vesicle endocytosis|generation of neurons|receptor-mediated endocytosis|regulation of neuron differentiation|synaptic transmission|clathrin-mediated endocytosis - - - - 1:202590596-202710417 6 6 10 24 21 35 0.0545924077294817 0.0496171613679466 0.0820402006646688 0.195661994385386 0.156779609870209 0.298467089686357 0.0620832565873657 0.216969564647317 -1.80521654174132 0.000231726881394824 0.00165938458075343 DOWN ENSG00000156463 SH3RF2 SH3 domain containing ring finger 2 [Source:HGNC Symbol;Acc:HGNC:26299] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0030234|GO:0016874|GO:0005622|GO:0005515|GO:0019222|GO:0004857|GO:0019208|GO:0043231|GO:0043169|GO:0019899|GO:0044092|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0046872|GO:0043412|GO:0036211|GO:0032269|GO:0019902|GO:0031981|GO:0051346|GO:0005654|GO:0019212|GO:0006796|GO:0044267|GO:0051174|GO:0019888|GO:0051246|GO:0005634|GO:0010923|GO:0016311|GO:0004864|GO:0019903|GO:0046914|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0008157|GO:0035305|GO:0008270|GO:0035303|GO:0035308|GO:0032446|GO:0016567 cell|cellular process|metabolic process|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|enzyme regulator activity|ligase activity|intracellular|protein binding|regulation of metabolic process|enzyme inhibitor activity|phosphatase regulator activity|intracellular membrane-bounded organelle|cation binding|enzyme binding|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|metal ion binding|macromolecule modification|protein modification process|negative regulation of cellular protein metabolic process|phosphatase binding|nuclear lumen|negative regulation of hydrolase activity|nucleoplasm|phosphatase inhibitor activity|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|protein phosphatase regulator activity|regulation of protein metabolic process|nucleus|negative regulation of phosphatase activity|dephosphorylation|protein phosphatase inhibitor activity|protein phosphatase binding|transition metal ion binding|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|protein phosphatase 1 binding|negative regulation of dephosphorylation|zinc ion binding|regulation of dephosphorylation|negative regulation of protein dephosphorylation|protein modification by small protein conjugation|protein ubiquitination - - - - 5:145936579-146081791 146 186 328 462 468 473 1.09996421525981 1.27355822629747 2.22799734456195 3.11864864534849 2.89294387016641 3.33977063602973 1.53383992870641 3.11712105051488 -1.02306625051057 0.000234526487056198 0.00167822477099131 DOWN ENSG00000165868 HSPA12A heat shock protein family A (Hsp70) member 12A [Source:HGNC Symbol;Acc:HGNC:19022] GO:0005576|GO:0005488|GO:0036094|GO:1903561|GO:0097159|GO:0043167|GO:0043227|GO:0043168|GO:0001882|GO:0031982|GO:0070062|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005524|GO:0030554 extracellular region|binding|small molecule binding|extracellular vesicle|organic cyclic compound binding|ion binding|membrane-bounded organelle|anion binding|nucleoside binding|vesicle|extracellular exosome|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|ATP binding|adenyl nucleotide binding - - - - 10:116671192-116742574 51 46 97 149 164 148 0.490826852071927 0.402342298726149 0.84167403711522 1.28482428659376 1.29499900789926 1.33489647628015 0.578281062637765 1.30490659025772 -1.17410377427911 0.000235331190532373 0.00168317617684558 DOWN ENSG00000132199 ENOSF1 enolase superfamily member 1 [Source:HGNC Symbol;Acc:HGNC:30365] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016853|GO:0005622|GO:0044262|GO:0006082|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0006520|GO:0005975|GO:0046872|GO:0044275|GO:0016836|GO:0009063|GO:0005739|GO:0016052|GO:0000287|GO:0046395|GO:0019752|GO:0050023 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|isomerase activity|intracellular|cellular carbohydrate metabolic process|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular amino acid metabolic process|carbohydrate metabolic process|metal ion binding|cellular carbohydrate catabolic process|hydro-lyase activity|cellular amino acid catabolic process|mitochondrion|carbohydrate catabolic process|magnesium ion binding|carboxylic acid catabolic process|carboxylic acid metabolic process|L-fuconate dehydratase activity K18334 L-fuconate dehydratase[4.2.1.68] hsa00051 Fructose and mannose metabolism - Homo sapiens (human) 18:670324-712676 130 166 137 340 361 241 0.509009229987537 0.590705864337736 0.483635531070058 1.19278116827141 1.15973420942752 0.884359520925568 0.527783541798444 1.0789582995415 -1.03162083942736 0.000235907605974005 0.00168649082106033 DOWN ENSG00000169967 MAP3K2 mitogen-activated protein kinase kinase kinase 2 [Source:HGNC Symbol;Acc:HGNC:6854] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0005057|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0023051|GO:0043227|GO:0009605|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0009612|GO:1901360|GO:0010941|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0009966|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0007165|GO:0004702|GO:0008219|GO:0050790|GO:0000166|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0046872|GO:0035639|GO:0043412|GO:0051252|GO:0001883|GO:0010628|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0031981|GO:0031098|GO:0007346|GO:0051247|GO:0005654|GO:0016301|GO:0019900|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0017076|GO:0031328|GO:0051246|GO:0071260|GO:0009059|GO:1902531|GO:0016070|GO:0004709|GO:0016773|GO:0010557|GO:0005634|GO:0043067|GO:0070304|GO:0045893|GO:0031401|GO:0043408|GO:0032774|GO:0005524|GO:2001141|GO:0030554|GO:0016310|GO:0043410|GO:0032872|GO:0042981|GO:0004672|GO:0019901|GO:0006464|GO:0051403|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0033674|GO:0000186|GO:0045859|GO:0045860|GO:0043406|GO:0046328|GO:0006468|GO:1903506|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0004674|GO:0032874|GO:0001934|GO:0042327|GO:0046330|GO:0043507|GO:0000187|GO:0071902|GO:0071900|GO:0043506|GO:0032147|GO:0007257 signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|receptor signaling protein activity|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|response to mechanical stimulus|organic cyclic compound metabolic process|regulation of cell death|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|signal transduction|receptor signaling protein serine/threonine kinase activity|cell death|regulation of catalytic activity|nucleotide binding|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of gene expression|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|positive regulation of protein metabolic process|nucleoplasm|kinase activity|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|purine nucleotide binding|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cellular response to mechanical stimulus|macromolecule biosynthetic process|regulation of intracellular signal transduction|RNA metabolic process|MAP kinase kinase kinase activity|phosphotransferase activity, alcohol group as acceptor|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|regulation of MAPK cascade|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|protein kinase activity|protein kinase binding|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of kinase activity|activation of MAPKK activity|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|regulation of JNK cascade|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of JNK cascade|positive regulation of JUN kinase activity|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|activation of protein kinase activity|activation of JUN kinase activity K04420 mitogen-activated protein kinase kinase kinase 2[2.7.11.25] hsa04010|hsa04912|hsa04540 MAPK signaling pathway - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Gap junction - Homo sapiens (human) 2:127298730-127388465 650 2237 728 474 518 543 3.83221672501017 11.9862400169598 3.86974665637941 2.50387549960384 2.50573352457763 3.000306118697 6.56273446611646 2.66997171429282 1.29747260353118 0.000236702601577988 0.00169136416168244 UP ENSG00000176381 PRR18 proline rich 18 [Source:HGNC Symbol;Acc:HGNC:28574] - - - - - - 6:166305300-166308448 11 8 2 0 1 0 0.212364171098325 0.140365288382248 0.0348133471597781 0 0.0158469507599215 0 0.129180935546784 0.00528231691997383 4.61207850275145 0.000243221958493521 0.00173421264601519 UP ENSG00000125735 TNFSF14 tumor necrosis factor superfamily member 14 [Source:HGNC Symbol;Acc:HGNC:11930] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0040012|GO:0051050|GO:0048520|GO:0071704|GO:0050900|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0050795|GO:0001776|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:1903828|GO:0009605|GO:0023057|GO:0031224|GO:0005615|GO:0030234|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0060341|GO:0051272|GO:0006949|GO:1900181|GO:0016337|GO:0004857|GO:0006935|GO:0045595|GO:0070661|GO:0002685|GO:0050867|GO:0006810|GO:0051130|GO:0009612|GO:0010941|GO:0060143|GO:0043028|GO:0070489|GO:0005102|GO:0030155|GO:0051128|GO:2000147|GO:0098609|GO:0061061|GO:0045597|GO:0051651|GO:0005737|GO:0050920|GO:0032880|GO:0051222|GO:0006928|GO:0042592|GO:0002687|GO:0008588|GO:0002696|GO:0001775|GO:0009966|GO:0045184|GO:0060548|GO:0032387|GO:0032388|GO:0010646|GO:1900182|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0051270|GO:0016477|GO:0007165|GO:0002260|GO:0009968|GO:0051649|GO:0045785|GO:0008219|GO:0090316|GO:0090317|GO:0030595|GO:0050790|GO:0031295|GO:0072676|GO:0043086|GO:0048869|GO:0016021|GO:2000145|GO:0009967|GO:0019538|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:0050921|GO:1902533|GO:0051249|GO:0032268|GO:0042307|GO:0051149|GO:0005126|GO:0032943|GO:0042308|GO:0002688|GO:0007166|GO:0072594|GO:0034097|GO:1901741|GO:0030414|GO:0042692|GO:0043069|GO:0002690|GO:0072678|GO:0032386|GO:0034109|GO:0051223|GO:0015031|GO:0005125|GO:0030334|GO:0051147|GO:0032269|GO:0070201|GO:0046907|GO:0042886|GO:0048872|GO:0051251|GO:0022407|GO:0043029|GO:0060326|GO:0007159|GO:0032507|GO:0051346|GO:0006508|GO:1904591|GO:0034613|GO:0042110|GO:0012501|GO:0035556|GO:0044267|GO:0017038|GO:0031503|GO:0071310|GO:1902532|GO:2000401|GO:0051246|GO:0071260|GO:0046651|GO:0030154|GO:0022409|GO:0030335|GO:0043027|GO:1903827|GO:1902531|GO:0043067|GO:0006606|GO:0048247|GO:1901739|GO:0051220|GO:0004866|GO:1904589|GO:0007520|GO:0010466|GO:0042098|GO:0051153|GO:0043124|GO:0019221|GO:0033365|GO:0033157|GO:0050863|GO:0043122|GO:0045445|GO:0051169|GO:0045663|GO:0032813|GO:0010820|GO:0030162|GO:2000404|GO:0015833|GO:2000406|GO:0006605|GO:0010818|GO:0034112|GO:0052547|GO:0045661|GO:0070486|GO:0016482|GO:0006886|GO:0043123|GO:0007249|GO:0042993|GO:0051146|GO:0042981|GO:0071345|GO:0042992|GO:0045861|GO:0043066|GO:0034612|GO:0042306|GO:0042345|GO:1900180|GO:0050870|GO:0051155|GO:0042991|GO:0006915|GO:1903039|GO:0046824|GO:0004869|GO:1903533|GO:0005164|GO:0006913|GO:0010831|GO:0042346|GO:0043281|GO:0071356|GO:0010951|GO:0014902|GO:0033209|GO:0010830|GO:0042990|GO:0042994|GO:0042347|GO:0043154|GO:0007253|GO:0071593|GO:0010819|GO:0034504|GO:0046822|GO:0052548|GO:0051170|GO:2000117|GO:2000116 locomotion|developmental process|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|regulation of locomotion|positive regulation of transport|positive regulation of behavior|organic substance metabolic process|leukocyte migration|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|regulation of behavior|leukocyte homeostasis|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|negative regulation of cellular protein localization|response to external stimulus|negative regulation of signaling|intrinsic component of membrane|extracellular space|enzyme regulator activity|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cellular localization|positive regulation of cellular component movement|syncytium formation|negative regulation of protein localization to nucleus|single organismal cell-cell adhesion|enzyme inhibitor activity|chemotaxis|regulation of cell differentiation|leukocyte proliferation|regulation of leukocyte migration|positive regulation of cell activation|transport|positive regulation of cellular component organization|response to mechanical stimulus|regulation of cell death|positive regulation of syncytium formation by plasma membrane fusion|cysteine-type endopeptidase regulator activity involved in apoptotic process|T cell aggregation|receptor binding|regulation of cell adhesion|regulation of cellular component organization|positive regulation of cell motility|cell-cell adhesion|muscle structure development|positive regulation of cell differentiation|maintenance of location in cell|cytoplasm|regulation of chemotaxis|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|homeostatic process|positive regulation of leukocyte migration|release of cytoplasmic sequestered NF-kappaB|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|establishment of protein localization|negative regulation of cell death|negative regulation of intracellular transport|positive regulation of intracellular transport|regulation of cell communication|positive regulation of protein localization to nucleus|protein localization|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|regulation of cellular component movement|cell migration|signal transduction|lymphocyte homeostasis|negative regulation of signal transduction|establishment of localization in cell|positive regulation of cell adhesion|cell death|positive regulation of intracellular protein transport|negative regulation of intracellular protein transport|leukocyte chemotaxis|regulation of catalytic activity|T cell costimulation|lymphocyte migration|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of chemotaxis|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|positive regulation of protein import into nucleus|positive regulation of muscle cell differentiation|cytokine receptor binding|mononuclear cell proliferation|negative regulation of protein import into nucleus|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|establishment of protein localization to organelle|response to cytokine|positive regulation of myoblast fusion|peptidase inhibitor activity|muscle cell differentiation|negative regulation of programmed cell death|positive regulation of leukocyte chemotaxis|T cell migration|regulation of intracellular transport|homotypic cell-cell adhesion|regulation of protein transport|protein transport|cytokine activity|regulation of cell migration|regulation of muscle cell differentiation|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|intracellular transport|amide transport|homeostasis of number of cells|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|T cell homeostasis|cell chemotaxis|leukocyte cell-cell adhesion|maintenance of protein location in cell|negative regulation of hydrolase activity|proteolysis|positive regulation of protein import|cellular protein localization|T cell activation|programmed cell death|intracellular signal transduction|cellular protein metabolic process|protein import|protein complex localization|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of lymphocyte migration|regulation of protein metabolic process|cellular response to mechanical stimulus|lymphocyte proliferation|cell differentiation|positive regulation of cell-cell adhesion|positive regulation of cell migration|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|regulation of cellular protein localization|regulation of intracellular signal transduction|regulation of programmed cell death|protein import into nucleus|lymphocyte chemotaxis|regulation of myoblast fusion|cytoplasmic sequestering of protein|endopeptidase inhibitor activity|regulation of protein import|myoblast fusion|negative regulation of peptidase activity|T cell proliferation|regulation of striated muscle cell differentiation|negative regulation of I-kappaB kinase/NF-kappaB signaling|cytokine-mediated signaling pathway|protein localization to organelle|regulation of intracellular protein transport|regulation of T cell activation|regulation of I-kappaB kinase/NF-kappaB signaling|myoblast differentiation|nuclear transport|positive regulation of myoblast differentiation|tumor necrosis factor receptor superfamily binding|positive regulation of T cell chemotaxis|regulation of proteolysis|regulation of T cell migration|peptide transport|positive regulation of T cell migration|protein targeting|T cell chemotaxis|positive regulation of homotypic cell-cell adhesion|regulation of peptidase activity|regulation of myoblast differentiation|leukocyte aggregation|cytosolic transport|intracellular protein transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription factor import into nucleus|striated muscle cell differentiation|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of transcription factor import into nucleus|negative regulation of proteolysis|negative regulation of apoptotic process|response to tumor necrosis factor|regulation of protein import into nucleus|regulation of NF-kappaB import into nucleus|regulation of protein localization to nucleus|positive regulation of T cell activation|positive regulation of striated muscle cell differentiation|transcription factor import into nucleus|apoptotic process|positive regulation of leukocyte cell-cell adhesion|positive regulation of nucleocytoplasmic transport|cysteine-type endopeptidase inhibitor activity|regulation of protein targeting|tumor necrosis factor receptor binding|nucleocytoplasmic transport|positive regulation of myotube differentiation|positive regulation of NF-kappaB import into nucleus|regulation of cysteine-type endopeptidase activity involved in apoptotic process|cellular response to tumor necrosis factor|negative regulation of endopeptidase activity|myotube differentiation|tumor necrosis factor-mediated signaling pathway|regulation of myotube differentiation|regulation of transcription factor import into nucleus|cytoplasmic sequestering of transcription factor|negative regulation of NF-kappaB import into nucleus|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|cytoplasmic sequestering of NF-kappaB|lymphocyte aggregation|regulation of T cell chemotaxis|protein localization to nucleus|regulation of nucleocytoplasmic transport|regulation of endopeptidase activity|nuclear import|negative regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity K05477 tumor necrosis factor ligand superfamily member 14[-] hsa04060|hsa05168|hsa04064 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human) 19:6661253-6670588 40 58 54 10 31 21 0.493541782631153 0.650386101619751 0.600723540810883 0.110554426315777 0.313832980564939 0.242829528420179 0.581550475020596 0.222405645100298 1.38671100721619 0.000247876478531255 0.00176402965198381 UP ENSG00000187260 WDR86 WD repeat domain 86 [Source:HGNC Symbol;Acc:HGNC:28020] GO:0005488|GO:0005515 binding|protein binding - - - - 7:151375909-151410727 61 44 51 24 19 27 0.624454305811753 0.409354745510717 0.470706299464802 0.220126822626916 0.159585579350395 0.259034251150448 0.501505116929091 0.212915551042586 1.2359830949495 0.00024796301689232 0.00176422495383778 UP ENSG00000152527 PLEKHH2 pleckstrin homology, MyTH4 and FERM domain containing H2 [Source:HGNC Symbol;Acc:HGNC:30506] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0048523|GO:0050794|GO:0043229|GO:0016043|GO:0071944|GO:0031252|GO:0005622|GO:0005515|GO:0005886|GO:0042802|GO:0005938|GO:0032535|GO:0051128|GO:0005737|GO:0032970|GO:0030027|GO:0008092|GO:0030029|GO:0006996|GO:0030864|GO:0032956|GO:0007010|GO:0003779|GO:0043242|GO:0043244|GO:0030036|GO:0033043|GO:0030832|GO:0005856|GO:0015629|GO:0043241|GO:0008064|GO:0051494|GO:0051493|GO:1901879|GO:0030863|GO:0007015|GO:0043624|GO:0030834|GO:0008154|GO:0030835|GO:0030042|GO:0051261 cell|membrane|cellular process|binding|cell projection|negative regulation of cellular process|regulation of cellular process|intracellular organelle|cellular component organization|cell periphery|cell leading edge|intracellular|protein binding|plasma membrane|identical protein binding|cell cortex|regulation of cellular component size|regulation of cellular component organization|cytoplasm|regulation of actin filament-based process|lamellipodium|cytoskeletal protein binding|actin filament-based process|organelle organization|cortical actin cytoskeleton|regulation of actin cytoskeleton organization|cytoskeleton organization|actin binding|negative regulation of protein complex disassembly|regulation of protein complex disassembly|actin cytoskeleton organization|regulation of organelle organization|regulation of actin filament length|cytoskeleton|actin cytoskeleton|protein complex disassembly|regulation of actin polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|regulation of protein depolymerization|cortical cytoskeleton|actin filament organization|cellular protein complex disassembly|regulation of actin filament depolymerization|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|actin filament depolymerization|protein depolymerization - - - - 2:43637273-43767987 41 39 140 155 200 461 0.242819970968437 0.209915874559744 0.74754914890143 0.822478190212084 0.971839172878619 2.55873547585815 0.400094998143204 1.45101761298295 -1.85865053366407 0.000248083454867771 0.0017646612965505 DOWN ENSG00000169855 ROBO1 roundabout guidance receptor 1 [Source:HGNC Symbol;Acc:HGNC:10249] GO:0040011|GO:0032502|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0004872|GO:0048523|GO:0048521|GO:0008283|GO:0050794|GO:0040012|GO:0071704|GO:0009986|GO:0044237|GO:0050795|GO:0038023|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0042127|GO:0006935|GO:0045595|GO:0009888|GO:0048468|GO:0051130|GO:0001568|GO:0010941|GO:0007275|GO:0048513|GO:0033600|GO:0030900|GO:0031325|GO:0051128|GO:0007420|GO:0060761|GO:0010942|GO:0098609|GO:0005887|GO:0045597|GO:0004888|GO:0005737|GO:0060322|GO:0021987|GO:0050920|GO:0006928|GO:0009966|GO:0050673|GO:0021988|GO:0008037|GO:0019904|GO:0010646|GO:0031226|GO:0043085|GO:0001525|GO:0007154|GO:0021772|GO:0016477|GO:0007165|GO:0009968|GO:0050922|GO:0008219|GO:0008285|GO:0021543|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:0021537|GO:0019538|GO:0010033|GO:0031323|GO:0048732|GO:0032268|GO:0008046|GO:0000902|GO:0031175|GO:0022029|GO:0098742|GO:0031344|GO:0050923|GO:0030879|GO:0002040|GO:0090132|GO:0033599|GO:0007166|GO:0001959|GO:0001944|GO:0072358|GO:0034097|GO:0007417|GO:0051345|GO:0010720|GO:0051604|GO:0030275|GO:0031346|GO:0000904|GO:0050919|GO:0001667|GO:0021885|GO:0022028|GO:0050769|GO:0051247|GO:0006508|GO:0008038|GO:0022604|GO:0050678|GO:0050680|GO:0021872|GO:0032270|GO:0012501|GO:0060429|GO:0021795|GO:0021889|GO:0050925|GO:0006929|GO:0044267|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0001960|GO:0010770|GO:0030154|GO:0048858|GO:0043068|GO:0072359|GO:0033598|GO:0043067|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0021953|GO:0021800|GO:0021891|GO:0010975|GO:0019221|GO:0043065|GO:0010769|GO:0016485|GO:0021836|GO:0030162|GO:0045862|GO:0016198|GO:0035385|GO:0052547|GO:0002042|GO:0061564|GO:0007156|GO:0021954|GO:0010631|GO:0042981|GO:0071345|GO:0070100|GO:0021879|GO:0050772|GO:0022008|GO:0048667|GO:0061180|GO:0050767|GO:0048812|GO:0010952|GO:0010976|GO:0006915|GO:0045666|GO:0010950|GO:0007409|GO:0043281|GO:0048699|GO:0016199|GO:0031638|GO:0021884|GO:0043280|GO:0006919|GO:0070098|GO:0043542|GO:0050770|GO:0045664|GO:0052548|GO:2001056|GO:2000116|GO:0097202|GO:0043534 locomotion|developmental process|signal transducer activity|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|receptor activity|negative regulation of cellular process|negative regulation of behavior|cell proliferation|regulation of cellular process|regulation of locomotion|organic substance metabolic process|cell surface|cellular metabolic process|regulation of behavior|signaling receptor activity|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|regulation of cell proliferation|chemotaxis|regulation of cell differentiation|tissue development|cell development|positive regulation of cellular component organization|blood vessel development|regulation of cell death|multicellular organism development|animal organ development|negative regulation of mammary gland epithelial cell proliferation|forebrain development|positive regulation of cellular metabolic process|regulation of cellular component organization|brain development|negative regulation of response to cytokine stimulus|positive regulation of cell death|cell-cell adhesion|integral component of plasma membrane|positive regulation of cell differentiation|transmembrane signaling receptor activity|cytoplasm|head development|cerebral cortex development|regulation of chemotaxis|movement of cell or subcellular component|regulation of signal transduction|epithelial cell proliferation|olfactory lobe development|cell recognition|protein domain specific binding|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|angiogenesis|cell communication|olfactory bulb development|cell migration|signal transduction|negative regulation of signal transduction|negative regulation of chemotaxis|cell death|negative regulation of cell proliferation|pallium development|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|telencephalon development|protein metabolic process|response to organic substance|regulation of cellular metabolic process|gland development|regulation of cellular protein metabolic process|axon guidance receptor activity|cell morphogenesis|neuron projection development|telencephalon cell migration|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of cell projection organization|regulation of negative chemotaxis|mammary gland development|sprouting angiogenesis|epithelium migration|regulation of mammary gland epithelial cell proliferation|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|vasculature development|cardiovascular system development|response to cytokine|central nervous system development|positive regulation of hydrolase activity|positive regulation of cell development|protein maturation|LRR domain binding|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|negative chemotaxis|ameboidal-type cell migration|forebrain cell migration|tangential migration from the subventricular zone to the olfactory bulb|positive regulation of neurogenesis|positive regulation of protein metabolic process|proteolysis|neuron recognition|regulation of cell morphogenesis|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|forebrain generation of neurons|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|cerebral cortex cell migration|olfactory bulb interneuron differentiation|negative regulation of negative chemotaxis|substrate-dependent cell migration|cellular protein metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|negative regulation of cytokine-mediated signaling pathway|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|circulatory system development|mammary gland epithelial cell proliferation|regulation of programmed cell death|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|central nervous system neuron differentiation|cerebral cortex tangential migration|olfactory bulb interneuron development|regulation of neuron projection development|cytokine-mediated signaling pathway|positive regulation of apoptotic process|regulation of cell morphogenesis involved in differentiation|protein processing|chemorepulsion involved in postnatal olfactory bulb interneuron migration|regulation of proteolysis|positive regulation of proteolysis|axon choice point recognition|Roundabout signaling pathway|regulation of peptidase activity|cell migration involved in sprouting angiogenesis|axon development|homophilic cell adhesion via plasma membrane adhesion molecules|central nervous system neuron development|epithelial cell migration|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of chemokine-mediated signaling pathway|forebrain neuron differentiation|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|mammary gland epithelium development|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of peptidase activity|positive regulation of neuron projection development|apoptotic process|positive regulation of neuron differentiation|positive regulation of endopeptidase activity|axonogenesis|regulation of cysteine-type endopeptidase activity involved in apoptotic process|generation of neurons|axon midline choice point recognition|zymogen activation|forebrain neuron development|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|chemokine-mediated signaling pathway|endothelial cell migration|regulation of axonogenesis|regulation of neuron differentiation|regulation of endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|blood vessel endothelial cell migration K06753 roundabout, axon guidance receptor 1[-] hsa04360 Axon guidance - Homo sapiens (human) 3:78597240-79767815 16 11 17 36 39 66 0.0639870685277894 0.0399813855454339 0.0612954268298994 0.128994039780303 0.127966859614308 0.247366764412744 0.0550879603010409 0.168109221269118 -1.60958991121256 0.000249799460403238 0.00177602121716558 DOWN ENSG00000280047 CTC-463A16.1 - - - - - - - 5:142165767-142168387 21 37 33 13 13 9 0.566770016533694 0.907539336735384 0.802992118166607 0.314352928188794 0.287857012782519 0.227639154959887 0.759100490478562 0.2766163653104 1.45640437125788 0.000249785047218437 0.00177602121716558 UP ENSG00000277504 RP11-278A23.4 - - - - - - - 16:87683945-87684477 5 8 7 1 1 0 0.663604024794135 0.964912601562018 0.837547823264776 0.118853271108465 0.10893663711886 0 0.822021483206976 0.0759299694091083 3.43643476661982 0.000250909561443032 0.00178264018260835 UP ENSG00000278570 NR2E3 nuclear receptor subfamily 2 group E member 3 [Source:HGNC Symbol;Acc:HGNC:7974] GO:0032502|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0051606|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0038023|GO:0009653|GO:0043227|GO:0009605|GO:0004879|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0098531|GO:0042127|GO:0006725|GO:0060041|GO:0003707|GO:0048468|GO:0009314|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0031325|GO:0046483|GO:0009582|GO:0043231|GO:0043169|GO:0000981|GO:0007423|GO:0009887|GO:0005667|GO:0009890|GO:0006139|GO:0007154|GO:0007165|GO:0009725|GO:0008285|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0001654|GO:0033993|GO:0009583|GO:0010629|GO:0051252|GO:0010628|GO:0007602|GO:0007600|GO:0031981|GO:0005654|GO:0014070|GO:0010467|GO:0007399|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0009755|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0009416|GO:0048545|GO:0030522|GO:0048666|GO:0030182|GO:0043401|GO:0042461|GO:0045893|GO:0050953|GO:0045892|GO:0043010|GO:0007468|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0071383|GO:0071407|GO:0046914|GO:0022008|GO:0045872|GO:0071396|GO:0006351|GO:0006355|GO:0048592|GO:0045944|GO:0006366|GO:1903507|GO:0006352|GO:0006357|GO:0048699|GO:1903506|GO:0001754|GO:0042462|GO:0000122|GO:0007601|GO:0008270|GO:0006367 developmental process|macromolecular complex|signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|detection of stimulus|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|signaling receptor activity|anatomical structure morphogenesis|membrane-bounded organelle|response to external stimulus|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|regulation of cell proliferation|cellular aromatic compound metabolic process|retina development in camera-type eye|steroid hormone receptor activity|cell development|response to radiation|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|detection of abiotic stimulus|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|sensory organ development|organ morphogenesis|transcription factor complex|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|signal transduction|response to hormone|negative regulation of cell proliferation|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|eye development|response to lipid|detection of light stimulus|negative regulation of gene expression|regulation of RNA metabolic process|positive regulation of gene expression|phototransduction|sensory perception|nuclear lumen|nucleoplasm|response to organic cyclic compound|gene expression|nervous system development|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to light stimulus|response to steroid hormone|intracellular receptor signaling pathway|neuron development|neuron differentiation|steroid hormone mediated signaling pathway|photoreceptor cell development|positive regulation of transcription, DNA-templated|sensory perception of light stimulus|negative regulation of transcription, DNA-templated|camera-type eye development|regulation of rhodopsin gene expression|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|transition metal ion binding|neurogenesis|positive regulation of rhodopsin gene expression|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|eye photoreceptor cell differentiation|eye photoreceptor cell development|negative regulation of transcription from RNA polymerase II promoter|visual perception|zinc ion binding|transcription initiation from RNA polymerase II promoter - - - - 15:71792638-71818259 1 0 1 10 5 8 0.0180573343767833 0 0.0162655467771994 0.161727105401466 0.0740494756886695 0.135329543192689 0.0114409603846609 0.123702041427608 -3.43458924301691 0.000254998353986245 0.00180910666822846 DOWN ENSG00000146453 PNLDC1 PARN like, ribonuclease domain containing 1 [Source:HGNC Symbol;Acc:HGNC:21185] GO:0005623|GO:0016020|GO:0005488|GO:0097159|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0003676|GO:0043231|GO:0016021|GO:0005634 cell|membrane|binding|organic cyclic compound binding|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|nucleic acid binding|intracellular membrane-bounded organelle|integral component of membrane|nucleus - - - - 6:159800249-159820704 19 9 2 1 0 1 0.388993003325495 0.16747211096078 0.0369192775668385 0.0183353960928544 0 0.019185454523218 0.197794797284371 0.0125069502053575 3.98320253930076 0.000255962146496745 0.00181508169157098 UP ENSG00000183671 GPR1 G protein-coupled receptor 1 [Source:HGNC Symbol;Acc:HGNC:4463] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0033218|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0042277|GO:0005887|GO:0004888|GO:0007267|GO:0043005|GO:0031226|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0042923|GO:0004930|GO:0007187|GO:0007218|GO:0007268 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|amide binding|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|peptide binding|integral component of plasma membrane|transmembrane signaling receptor activity|cell-cell signaling|neuron projection|intrinsic component of plasma membrane|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|neuropeptide binding|G-protein coupled receptor activity|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|neuropeptide signaling pathway|synaptic transmission - - - - 2:206175316-206218047 7 4 17 28 44 29 0.0545940541468141 0.0283516216445731 0.11953621937897 0.195655981783829 0.281552117759843 0.211962311599232 0.0674939650567857 0.229723470380968 -1.76706784637171 0.000260850377910578 0.00184623688528744 DOWN ENSG00000163536 SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 [Source:HGNC Symbol;Acc:HGNC:8943] GO:0032502|GO:0009987|GO:0005576|GO:0008152|GO:1903561|GO:0009892|GO:0048523|GO:0050794|GO:0071704|GO:0044237|GO:0007155|GO:0043227|GO:0005615|GO:0030234|GO:0048856|GO:0019222|GO:0004857|GO:0007275|GO:0030155|GO:0031982|GO:0044092|GO:0070062|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0007417|GO:0030414|GO:0032269|GO:0051346|GO:0006508|GO:0044267|GO:0007399|GO:0051246|GO:0007422|GO:0004866|GO:0010466|GO:0030162|GO:0052547|GO:0045861|GO:0010951|GO:0004867|GO:0052548 developmental process|cellular process|extracellular region|metabolic process|extracellular vesicle|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|cellular metabolic process|cell adhesion|membrane-bounded organelle|extracellular space|enzyme regulator activity|anatomical structure development|regulation of metabolic process|enzyme inhibitor activity|multicellular organism development|regulation of cell adhesion|vesicle|negative regulation of molecular function|extracellular exosome|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|central nervous system development|peptidase inhibitor activity|negative regulation of cellular protein metabolic process|negative regulation of hydrolase activity|proteolysis|cellular protein metabolic process|nervous system development|regulation of protein metabolic process|peripheral nervous system development|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of proteolysis|regulation of peptidase activity|negative regulation of proteolysis|negative regulation of endopeptidase activity|serine-type endopeptidase inhibitor activity|regulation of endopeptidase activity - - - - 3:167735243-167825568 39 52 47 26 13 20 0.72559398905886 0.879258208340772 0.788392509551533 0.433413479633261 0.19844114426696 0.348725918215457 0.797748235650388 0.326860180705226 1.28725987929575 0.000263547399410692 0.00186311722993294 UP ENSG00000265203 RBP3 retinol binding protein 3 [Source:HGNC Symbol;Acc:HGNC:9921] GO:0031012|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0051606|GO:0050794|GO:0005578|GO:0071704|GO:0009628|GO:0044237|GO:0043227|GO:0008289|GO:0009605|GO:0016787|GO:0005615|GO:0019840|GO:0044255|GO:0009314|GO:0006810|GO:0050877|GO:0031982|GO:0009582|GO:0043178|GO:0008233|GO:0019842|GO:0007154|GO:0006629|GO:0007165|GO:0033165|GO:0019538|GO:0017171|GO:0016918|GO:0019841|GO:0009583|GO:0006720|GO:0005501|GO:0007602|GO:0007600|GO:0006508|GO:0008236|GO:0009416|GO:0050953|GO:0009584|GO:0007603|GO:0016101|GO:0007601|GO:0001523 extracellular matrix|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|detection of stimulus|regulation of cellular process|proteinaceous extracellular matrix|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|membrane-bounded organelle|lipid binding|response to external stimulus|hydrolase activity|extracellular space|isoprenoid binding|cellular lipid metabolic process|response to radiation|transport|neurological system process|vesicle|detection of abiotic stimulus|alcohol binding|peptidase activity|vitamin binding|cell communication|lipid metabolic process|signal transduction|interphotoreceptor matrix|protein metabolic process|serine hydrolase activity|retinal binding|retinol binding|detection of light stimulus|isoprenoid metabolic process|retinoid binding|phototransduction|sensory perception|proteolysis|serine-type peptidase activity|response to light stimulus|sensory perception of light stimulus|detection of visible light|phototransduction, visible light|diterpenoid metabolic process|visual perception|retinoid metabolic process - - - - 10:47348371-47357875 3 3 4 15 11 26 0.0496337276237006 0.0451104609202709 0.0596614144029125 0.222329450420135 0.149299554883819 0.403096569240383 0.051468534315628 0.258241858181446 -2.32696026049274 0.0002651107894863 0.0018737257361089 DOWN ENSG00000185070 FLRT2 fibronectin leucine rich transmembrane protein 2 [Source:HGNC Symbol;Acc:HGNC:3761] GO:0040011|GO:0032502|GO:0031012|GO:0004871|GO:0045499|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0060090|GO:0051716|GO:0042995|GO:0009892|GO:0030055|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0005578|GO:0044089|GO:0005057|GO:0042175|GO:0071704|GO:0044237|GO:0048870|GO:0023051|GO:0005911|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0031224|GO:0005615|GO:0030234|GO:0050793|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0007507|GO:0051726|GO:0007049|GO:0004857|GO:0006935|GO:0045595|GO:0048468|GO:0051130|GO:0007275|GO:0048513|GO:0005102|GO:0005924|GO:0043062|GO:0005912|GO:0031982|GO:0051128|GO:0022607|GO:0050803|GO:0005887|GO:0043231|GO:0005737|GO:0006928|GO:0051963|GO:0009887|GO:0043005|GO:0009966|GO:0030674|GO:0010646|GO:0031226|GO:0007154|GO:0044092|GO:0051270|GO:0016477|GO:0007165|GO:0051965|GO:0005783|GO:0009968|GO:0070062|GO:0050808|GO:0050790|GO:0030030|GO:0019207|GO:0043086|GO:0048869|GO:0016021|GO:2000145|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0061343|GO:0071774|GO:0032268|GO:0000902|GO:0031175|GO:0019210|GO:0007416|GO:0007166|GO:0070851|GO:0043412|GO:0050807|GO:0072358|GO:0034097|GO:0019887|GO:0003007|GO:0000904|GO:0050919|GO:0030334|GO:0036211|GO:0032269|GO:0001764|GO:0044344|GO:0070848|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:1902532|GO:0030198|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0072359|GO:0051960|GO:0005925|GO:0048666|GO:0030182|GO:0007411|GO:2001222|GO:0019221|GO:0008543|GO:0005104|GO:0071363|GO:0016310|GO:0071711|GO:1904030|GO:0061564|GO:0007167|GO:0004860|GO:0071345|GO:0033673|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0048812|GO:0043549|GO:0007259|GO:0045859|GO:0006469|GO:0007409|GO:0006468|GO:0048699|GO:0046425|GO:0042325|GO:0046426|GO:0001932|GO:0042326|GO:0001933|GO:0007169 locomotion|developmental process|extracellular matrix|signal transducer activity|chemorepellent activity|synapse|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|binding, bridging|cellular response to stimulus|cell projection|negative regulation of metabolic process|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|proteinaceous extracellular matrix|positive regulation of cellular component biogenesis|receptor signaling protein activity|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cell motility|regulation of signaling|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|intrinsic component of membrane|extracellular space|enzyme regulator activity|regulation of developmental process|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|heart development|regulation of cell cycle|cell cycle|enzyme inhibitor activity|chemotaxis|regulation of cell differentiation|cell development|positive regulation of cellular component organization|multicellular organism development|animal organ development|receptor binding|cell-substrate adherens junction|extracellular structure organization|adherens junction|vesicle|regulation of cellular component organization|cellular component assembly|regulation of synapse structure or activity|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|regulation of synapse assembly|organ morphogenesis|neuron projection|regulation of signal transduction|protein binding, bridging|regulation of cell communication|intrinsic component of plasma membrane|cell communication|negative regulation of molecular function|regulation of cellular component movement|cell migration|signal transduction|positive regulation of synapse assembly|endoplasmic reticulum|negative regulation of signal transduction|extracellular exosome|synapse organization|regulation of catalytic activity|cell projection organization|kinase regulator activity|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|regulation of cell motility|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|cell adhesion involved in heart morphogenesis|response to fibroblast growth factor|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|kinase inhibitor activity|synapse assembly|cell surface receptor signaling pathway|growth factor receptor binding|macromolecule modification|regulation of synapse organization|cardiovascular system development|response to cytokine|protein kinase regulator activity|heart morphogenesis|cell morphogenesis involved in differentiation|negative chemotaxis|regulation of cell migration|protein modification process|negative regulation of cellular protein metabolic process|neuron migration|cellular response to fibroblast growth factor stimulus|response to growth factor|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|negative regulation of intracellular signal transduction|extracellular matrix organization|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|circulatory system development|regulation of nervous system development|focal adhesion|neuron development|neuron differentiation|axon guidance|regulation of neuron migration|cytokine-mediated signaling pathway|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor binding|cellular response to growth factor stimulus|phosphorylation|basement membrane organization|negative regulation of cyclin-dependent protein kinase activity|axon development|enzyme linked receptor protein signaling pathway|protein kinase inhibitor activity|cellular response to cytokine stimulus|negative regulation of kinase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|regulation of kinase activity|JAK-STAT cascade|regulation of protein kinase activity|negative regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of JAK-STAT cascade|regulation of phosphorylation|negative regulation of JAK-STAT cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway - - - - 14:85530144-85654426 20 10 13 48 45 41 0.0352591346802961 0.0160221568335833 0.0206629773148342 0.075818779002691 0.0650917390007509 0.0677417043225613 0.0239814229429045 0.0695507407753344 -1.53614861688159 0.000265185799351393 0.00187381227309739 DOWN ENSG00000261884 CTC-479C5.12 - GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0071704|GO:0009056|GO:0044237|GO:0016787|GO:0005622|GO:0043234|GO:0008233|GO:0005839|GO:0000502|GO:0019538|GO:0030163|GO:0044265|GO:0006508|GO:0044267|GO:0044257|GO:0051603|GO:0004175|GO:0004298 macromolecular complex|cell|cellular process|metabolic process|catalytic activity|organic substance metabolic process|catabolic process|cellular metabolic process|hydrolase activity|intracellular|protein complex|peptidase activity|proteasome core complex|proteasome complex|protein metabolic process|protein catabolic process|cellular macromolecule catabolic process|proteolysis|cellular protein metabolic process|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|endopeptidase activity|threonine-type endopeptidase activity - - - - 16:67929614-67936017 84 70 47 29 37 19 0.949486150757663 0.719097338692052 0.478981834662021 0.293706082852698 0.343146289395671 0.201273601098985 0.715855108037245 0.279375324449118 1.35746300798571 0.000265480405499356 0.00187545007708892 UP ENSG00000149591 TAGLN transgelin [Source:HGNC Symbol;Acc:HGNC:11553] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0005622|GO:0005515|GO:0048856|GO:0009888|GO:0007275|GO:0048513|GO:0061061|GO:0005737|GO:0008092|GO:0048869|GO:0003779|GO:0060429|GO:0030154|GO:0007517|GO:0030855 developmental process|cell|cellular process|binding|intracellular|protein binding|anatomical structure development|tissue development|multicellular organism development|animal organ development|muscle structure development|cytoplasm|cytoskeletal protein binding|cellular developmental process|actin binding|epithelium development|cell differentiation|muscle organ development|epithelial cell differentiation - - - - 11:117199321-117204782 56 47 37 17 22 22 0.447753849660217 0.341532002076878 0.266729348898105 0.12178619138806 0.144327785092727 0.164857912123997 0.3520050668784 0.143657296201595 1.29296492796483 0.000265553346855707 0.00187552155595701 UP ENSG00000128573 FOXP2 forkhead box P2 [Source:HGNC Symbol;Acc:HGNC:13875] GO:0032502|GO:0040007|GO:0007610|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0009653|GO:0043227|GO:0044708|GO:0009605|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0042802|GO:0008284|GO:0042127|GO:0048286|GO:0021544|GO:0009791|GO:0006725|GO:0009888|GO:0035295|GO:0009612|GO:1901360|GO:0007275|GO:0007638|GO:0030324|GO:0003676|GO:0048513|GO:0048857|GO:0050877|GO:0034641|GO:0030902|GO:0030900|GO:0046483|GO:0007420|GO:0061061|GO:0043231|GO:0060004|GO:0043169|GO:0000981|GO:0060322|GO:0021987|GO:0007423|GO:0009887|GO:0046983|GO:0050673|GO:0009890|GO:0030323|GO:0006139|GO:0021756|GO:0022037|GO:0060501|GO:0007611|GO:0021543|GO:0021549|GO:0048869|GO:0021537|GO:0044249|GO:0031324|GO:0031323|GO:0072089|GO:0060425|GO:0050679|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0001654|GO:0007417|GO:0007612|GO:0010629|GO:0046982|GO:0051252|GO:0060541|GO:0010463|GO:0060502|GO:0060537|GO:0021758|GO:0031223|GO:2000027|GO:0060013|GO:0050678|GO:0021757|GO:0060429|GO:0010467|GO:0007399|GO:0001227|GO:0050890|GO:0009059|GO:0030154|GO:0010996|GO:0007517|GO:0016070|GO:0060428|GO:0005634|GO:0042803|GO:2000648|GO:0072091|GO:0060538|GO:0000975|GO:0001078|GO:0045892|GO:0043010|GO:2000794|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0002053|GO:0048745|GO:0014706|GO:0098597|GO:0006351|GO:0006355|GO:0042297|GO:0010464|GO:0006366|GO:1903507|GO:0006357|GO:0007519|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|growth|behavior|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|single-organism behavior|response to external stimulus|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|identical protein binding|positive regulation of cell proliferation|regulation of cell proliferation|lung alveolus development|subpallium development|post-embryonic development|cellular aromatic compound metabolic process|tissue development|tube development|response to mechanical stimulus|organic cyclic compound metabolic process|multicellular organism development|mechanosensory behavior|lung development|nucleic acid binding|animal organ development|neural nucleus development|neurological system process|cellular nitrogen compound metabolic process|hindbrain development|forebrain development|heterocycle metabolic process|brain development|muscle structure development|intracellular membrane-bounded organelle|reflex|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|cerebral cortex development|sensory organ development|organ morphogenesis|protein dimerization activity|epithelial cell proliferation|negative regulation of biosynthetic process|respiratory tube development|nucleobase-containing compound metabolic process|striatum development|metencephalon development|positive regulation of epithelial cell proliferation involved in lung morphogenesis|learning or memory|pallium development|cerebellum development|cellular developmental process|telencephalon development|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|stem cell proliferation|lung morphogenesis|positive regulation of epithelial cell proliferation|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|eye development|central nervous system development|learning|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|respiratory system development|mesenchymal cell proliferation|epithelial cell proliferation involved in lung morphogenesis|muscle tissue development|putamen development|auditory behavior|regulation of organ morphogenesis|righting reflex|regulation of epithelial cell proliferation|caudate nucleus development|epithelium development|gene expression|nervous system development|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|cognition|macromolecule biosynthetic process|cell differentiation|response to auditory stimulus|muscle organ development|RNA metabolic process|lung epithelium development|nucleus|protein homodimerization activity|positive regulation of stem cell proliferation|regulation of stem cell proliferation|skeletal muscle organ development|regulatory region DNA binding|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|negative regulation of transcription, DNA-templated|camera-type eye development|regulation of epithelial cell proliferation involved in lung morphogenesis|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|positive regulation of mesenchymal cell proliferation|smooth muscle tissue development|striated muscle tissue development|observational learning|transcription, DNA-templated|regulation of transcription, DNA-templated|vocal learning|regulation of mesenchymal cell proliferation|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 7:114086327-114693772 0 0 0 4 4 7 0 0 0 0.00753054744927639 0.0068952850840475 0.0137845522008682 0 0.00940346157806403 -Inf 0.000268017109064099 0.00189113277570305 DOWN ENSG00000235408 SNORA71B small nucleolar RNA, H/ACA box 71B [Source:HGNC Symbol;Acc:HGNC:10233] - - - - - - 20:38425083-38425354 11 18 9 2 4 3 1.91650818449326 2.85017595424446 1.41371697978708 0.312220948802141 0.571765191230402 0.489796148111217 2.06013370617493 0.457927429381253 2.1695470851455 0.000269677152435813 0.0019023964340309 UP ENSG00000104903 LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 [Source:HGNC Symbol;Acc:HGNC:6734] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0001568|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0001775|GO:0046983|GO:0006139|GO:0046649|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0042113|GO:0010468|GO:0034645|GO:0001955|GO:0001944|GO:0030097|GO:0072358|GO:0030098|GO:0051252|GO:0010628|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0002521|GO:0000975|GO:0045893|GO:0030183|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0060216|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 developmental process|immune system process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|immune system development|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cell activation|protein dimerization activity|nucleobase-containing compound metabolic process|lymphocyte activation|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|blood vessel maturation|vasculature development|hemopoiesis|cardiovascular system development|lymphocyte differentiation|regulation of RNA metabolic process|positive regulation of gene expression|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|leukocyte differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|B cell differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|definitive hemopoiesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding K15604 protein lyl-1[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 19:13099033-13103161 6 6 2 0 0 0 0.107743431756535 0.0979242986733732 0.0323828646848 0 0 0 0.0793501983715694 0 Inf 0.000269907238946891 0.00190356974049622 UP ENSG00000130701 RBBP8NL RBBP8 N-terminal like [Source:HGNC Symbol;Acc:HGNC:16144] GO:0005576|GO:0005615 extracellular region|extracellular space - - - - 20:62410237-62427533 97 80 111 192 206 222 2.45666085937775 1.84138351819748 2.5346211603118 4.35687038712495 4.2806487942433 5.26934081967915 2.27755517929568 4.63562000034913 -1.02527630067882 0.000270134859416446 0.00190472510463358 DOWN ENSG00000179564 LSMEM2 leucine-rich single-pass membrane protein 2 [Source:HGNC Symbol;Acc:HGNC:26781] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 3:50279027-50288114 9 7 13 1 2 2 0.426127976578269 0.301232623300774 0.554940630375105 0.0424021375507443 0.0776896478043987 0.0887359375873067 0.427433743418049 0.0696092409808166 2.61835005590405 0.000271806980189115 0.00191561038398627 UP ENSG00000144476 ACKR3 atypical chemokine receptor 3 [Source:HGNC Symbol;Acc:HGNC:23692] GO:0040011|GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0009986|GO:0044237|GO:0006914|GO:0038023|GO:0023051|GO:0009653|GO:0051707|GO:0007155|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0031224|GO:0005905|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0016032|GO:0048514|GO:0006935|GO:0006810|GO:0031623|GO:0001568|GO:0010941|GO:0007275|GO:0050688|GO:0006952|GO:0031325|GO:0033554|GO:0098542|GO:0043231|GO:0004888|GO:0005737|GO:0009615|GO:0009966|GO:0060548|GO:0010646|GO:0001525|GO:0007154|GO:0007165|GO:0009968|GO:0019955|GO:0008219|GO:0016236|GO:0051607|GO:0015026|GO:0048869|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0038024|GO:0005768|GO:0000165|GO:0016192|GO:1902533|GO:0032268|GO:1902230|GO:0007186|GO:0098792|GO:0007166|GO:0001944|GO:0043412|GO:0072358|GO:0004896|GO:0034097|GO:0005769|GO:0043069|GO:2001234|GO:0036211|GO:0055037|GO:2001020|GO:0001570|GO:0051247|GO:0048471|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:1902532|GO:0051246|GO:0030154|GO:0008528|GO:1902531|GO:0072359|GO:0004930|GO:0043067|GO:0006974|GO:0019956|GO:0097190|GO:0005044|GO:0050691|GO:0043112|GO:0097193|GO:0019221|GO:2001242|GO:0031401|GO:0043408|GO:2001243|GO:0016310|GO:0070371|GO:0002230|GO:0008630|GO:0043410|GO:0042981|GO:0071345|GO:0043066|GO:0004950|GO:0019958|GO:0006897|GO:0006464|GO:0006915|GO:0006468|GO:0042325|GO:0070374|GO:0016494|GO:0001932|GO:0006898|GO:0001934|GO:0070372|GO:0070098|GO:0042327 locomotion|developmental process|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cell surface|cellular metabolic process|autophagy|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|response to other organism|cell adhesion|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|coated pit|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|viral process|blood vessel morphogenesis|chemotaxis|transport|receptor internalization|blood vessel development|regulation of cell death|multicellular organism development|regulation of defense response to virus|defense response|positive regulation of cellular metabolic process|cellular response to stress|defense response to other organism|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|response to virus|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|angiogenesis|cell communication|signal transduction|negative regulation of signal transduction|cytokine binding|cell death|macroautophagy|defense response to virus|coreceptor activity|cellular developmental process|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|cargo receptor activity|endosome|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|G-protein coupled receptor signaling pathway|xenophagy|cell surface receptor signaling pathway|vasculature development|macromolecule modification|cardiovascular system development|cytokine receptor activity|response to cytokine|early endosome|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|protein modification process|recycling endosome|regulation of response to DNA damage stimulus|vasculogenesis|positive regulation of protein metabolic process|perinuclear region of cytoplasm|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of protein metabolic process|cell differentiation|G-protein coupled peptide receptor activity|regulation of intracellular signal transduction|circulatory system development|G-protein coupled receptor activity|regulation of programmed cell death|cellular response to DNA damage stimulus|chemokine binding|apoptotic signaling pathway|scavenger receptor activity|regulation of defense response to virus by host|receptor metabolic process|intrinsic apoptotic signaling pathway|cytokine-mediated signaling pathway|regulation of intrinsic apoptotic signaling pathway|positive regulation of protein modification process|regulation of MAPK cascade|negative regulation of intrinsic apoptotic signaling pathway|phosphorylation|ERK1 and ERK2 cascade|positive regulation of defense response to virus by host|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of apoptotic process|chemokine receptor activity|C-X-C chemokine binding|endocytosis|cellular protein modification process|apoptotic process|protein phosphorylation|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|C-X-C chemokine receptor activity|regulation of protein phosphorylation|receptor-mediated endocytosis|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|chemokine-mediated signaling pathway|positive regulation of phosphorylation K04304 C-X-C chemokine receptor type 7[-] hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) 2:236567787-236582358 12 20 31 56 49 71 0.291107344419368 0.44092799779883 0.678013113073131 1.21714660821627 0.975266667800299 1.61414679554911 0.470016151763776 1.26885335718856 -1.43274310500017 0.000274479681174235 0.00193159883003554 DOWN ENSG00000254471 RP11-885L14.1 - - - - - - - 11:79987513-79989630 4 4 4 20 22 12 0.133585576861502 0.121411335371236 0.120449578841763 0.598466918755736 0.602864926683359 0.375589925062804 0.125148830358167 0.5256405901673 -2.07043187777295 0.000274528499894179 0.00193159883003554 DOWN ENSG00000261915 RP11-542C16.2 - - - - - - - 17:7312661-7319174 0 86 0 0 0 0 0 1.89209718644763 0 0 0 0 0.63069906214921 0 Inf 0.000276631633259412 0.00194456340459772 UP ENSG00000257511 RP11-278C7.1 - - - - - - - 12:32726383-32727387 47 43 35 12 12 25 3.30810259794627 2.75063125776901 2.22109298080408 0.756786299783101 0.693003108723943 1.6491096365116 2.75994227883979 1.03296634833955 1.4178448396448 0.000276790171682353 0.00194476201115673 UP ENSG00000231185 AC005592.2 - - - - - - - 5:142325293-142672001 2 3 1 16 17 7 0.0550241640981447 0.0750261886017419 0.0247937292181425 0.394410549785029 0.383768191167429 0.180502035937156 0.0516146939726764 0.319560258963205 -2.63023425941595 0.00027756786919344 0.0019488502273991 DOWN ENSG00000280128 XXbac-BPG283O16.9 - - - - - - - 6:30282349-30286054 105 131 148 228 253 364 2.00415233264335 2.2724411756654 2.54691977930347 3.8991693061689 3.96213204312127 6.51134472146699 2.27450442920407 4.79088202358572 -1.07473904322651 0.000278412316735971 0.00195294203567568 DOWN ENSG00000182389 CACNB4 calcium channel, voltage-dependent, beta 4 subunit [Source:HGNC Symbol;Acc:HGNC:1404] GO:0040011|GO:0032502|GO:0032991|GO:0005215|GO:0002376|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0022857|GO:0051606|GO:0050794|GO:0006807|GO:0071704|GO:0006955|GO:0009628|GO:0044237|GO:0009653|GO:0016043|GO:0044708|GO:0071944|GO:0009605|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0007626|GO:0048856|GO:0002757|GO:0009898|GO:0008344|GO:0042391|GO:0006935|GO:0006725|GO:0009888|GO:0048468|GO:0030534|GO:0009314|GO:0006810|GO:1901360|GO:0098797|GO:0007275|GO:0048513|GO:0050877|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0009582|GO:0061061|GO:0019899|GO:0005737|GO:0007267|GO:0006928|GO:0042592|GO:0098562|GO:0019725|GO:0022891|GO:0006139|GO:0050776|GO:0055086|GO:0050906|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0050778|GO:0050808|GO:0030030|GO:0048869|GO:0016021|GO:0048732|GO:0000902|GO:0005829|GO:0031175|GO:0007186|GO:0048538|GO:0007166|GO:0051899|GO:0009583|GO:0007528|GO:0019227|GO:0019693|GO:0042692|GO:0048878|GO:0048536|GO:0000904|GO:0001508|GO:0007628|GO:0015267|GO:0006811|GO:0048537|GO:0055082|GO:0002429|GO:0015075|GO:0007600|GO:0005891|GO:0019226|GO:0034765|GO:0034702|GO:0002764|GO:0055001|GO:0043269|GO:0019900|GO:0006796|GO:0032990|GO:0007399|GO:0046903|GO:0097485|GO:0030154|GO:0048858|GO:0009416|GO:0022898|GO:0034220|GO:0048666|GO:0030182|GO:0055002|GO:0007411|GO:0050953|GO:0098655|GO:0006820|GO:0015711|GO:0005216|GO:0009259|GO:0009117|GO:0048541|GO:0034703|GO:0006812|GO:0007214|GO:0050908|GO:0002768|GO:0061564|GO:0046942|GO:0032412|GO:0009584|GO:0006163|GO:0051146|GO:0050801|GO:0006865|GO:0019901|GO:0022008|GO:0048667|GO:0050851|GO:0048812|GO:0046717|GO:0006873|GO:0008324|GO:0015718|GO:1903169|GO:0005244|GO:0007409|GO:0048699|GO:0015812|GO:0014051|GO:0048747|GO:0034704|GO:0022890|GO:1901019|GO:0009187|GO:0030001|GO:0051924|GO:0050852|GO:0005261|GO:2001257|GO:0007601|GO:0030003|GO:0007268|GO:0005262|GO:1901385|GO:0070588|GO:0046058|GO:0022843|GO:0007270|GO:0055065|GO:0006875|GO:0046873|GO:0006874|GO:0006816|GO:0035249|GO:0055074|GO:0015085|GO:0005245|GO:0008331 locomotion|developmental process|macromolecular complex|transporter activity|immune system process|synapse|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|transmembrane transporter activity|detection of stimulus|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|immune response|response to abiotic stimulus|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|single-organism behavior|cell periphery|response to external stimulus|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|locomotory behavior|anatomical structure development|immune response-activating signal transduction|cytoplasmic side of plasma membrane|adult locomotory behavior|regulation of membrane potential|chemotaxis|cellular aromatic compound metabolic process|tissue development|cell development|adult behavior|response to radiation|transport|organic cyclic compound metabolic process|plasma membrane protein complex|multicellular organism development|animal organ development|neurological system process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|detection of abiotic stimulus|muscle structure development|enzyme binding|cytoplasm|cell-cell signaling|movement of cell or subcellular component|homeostatic process|cytoplasmic side of membrane|cellular homeostasis|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|regulation of immune response|nucleobase-containing small molecule metabolic process|detection of stimulus involved in sensory perception|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|positive regulation of immune response|synapse organization|cell projection organization|cellular developmental process|integral component of membrane|gland development|cell morphogenesis|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|thymus development|cell surface receptor signaling pathway|membrane depolarization|detection of light stimulus|neuromuscular junction development|neuronal action potential propagation|ribose phosphate metabolic process|muscle cell differentiation|chemical homeostasis|spleen development|cell morphogenesis involved in differentiation|action potential|adult walking behavior|channel activity|ion transport|mucosal-associated lymphoid tissue development|cellular chemical homeostasis|immune response-activating cell surface receptor signaling pathway|ion transmembrane transporter activity|sensory perception|voltage-gated calcium channel complex|transmission of nerve impulse|regulation of ion transmembrane transport|ion channel complex|immune response-regulating signaling pathway|muscle cell development|regulation of ion transport|kinase binding|phosphate-containing compound metabolic process|cell part morphogenesis|nervous system development|secretion|neuron projection guidance|cell differentiation|cell projection morphogenesis|response to light stimulus|regulation of transmembrane transporter activity|ion transmembrane transport|neuron development|neuron differentiation|striated muscle cell development|axon guidance|sensory perception of light stimulus|cation transmembrane transport|anion transport|organic anion transport|ion channel activity|ribonucleotide metabolic process|nucleotide metabolic process|Peyer's patch development|cation channel complex|cation transport|gamma-aminobutyric acid signaling pathway|detection of light stimulus involved in visual perception|immune response-regulating cell surface receptor signaling pathway|axon development|carboxylic acid transport|regulation of ion transmembrane transporter activity|detection of visible light|purine nucleotide metabolic process|striated muscle cell differentiation|ion homeostasis|amino acid transport|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|antigen receptor-mediated signaling pathway|neuron projection morphogenesis|acid secretion|cellular ion homeostasis|cation transmembrane transporter activity|monocarboxylic acid transport|regulation of calcium ion transmembrane transport|voltage-gated ion channel activity|axonogenesis|generation of neurons|gamma-aminobutyric acid transport|gamma-aminobutyric acid secretion|muscle fiber development|calcium channel complex|inorganic cation transmembrane transporter activity|regulation of calcium ion transmembrane transporter activity|cyclic nucleotide metabolic process|metal ion transport|regulation of calcium ion transport|T cell receptor signaling pathway|cation channel activity|regulation of cation channel activity|visual perception|cellular cation homeostasis|synaptic transmission|calcium channel activity|regulation of voltage-gated calcium channel activity|calcium ion transmembrane transport|cAMP metabolic process|voltage-gated cation channel activity|neuron-neuron synaptic transmission|metal ion homeostasis|cellular metal ion homeostasis|metal ion transmembrane transporter activity|cellular calcium ion homeostasis|calcium ion transport|synaptic transmission, glutamatergic|calcium ion homeostasis|calcium ion transmembrane transporter activity|voltage-gated calcium channel activity|high voltage-gated calcium channel activity K04865 voltage-dependent calcium channel beta-4[-] hsa04010|hsa04921|hsa04261|hsa05414|hsa05410|hsa04260|hsa05412 MAPK signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 2:151832776-152099079 0 0 0 6 3 6 0 0 0 0.0209766184368144 0.00960513880545668 0.021941915660914 0 0.0175078909677284 -Inf 0.000281065391404761 0.00196970098474125 DOWN ENSG00000158079 PTPDC1 protein tyrosine phosphatase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30184] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0048856|GO:0016788|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0030030|GO:0048869|GO:0019538|GO:0000902|GO:0007166|GO:0043412|GO:0036211|GO:0031981|GO:0005654|GO:0006796|GO:0044267|GO:0032990|GO:0048858|GO:0005634|GO:0042578|GO:0060271|GO:0016311|GO:0007224|GO:0016791|GO:0006464|GO:0006470|GO:0004721|GO:0035335|GO:0008138|GO:0004725 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|anatomical structure development|hydrolase activity, acting on ester bonds|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|cell projection organization|cellular developmental process|protein metabolic process|cell morphogenesis|cell surface receptor signaling pathway|macromolecule modification|protein modification process|nuclear lumen|nucleoplasm|phosphate-containing compound metabolic process|cellular protein metabolic process|cell part morphogenesis|cell projection morphogenesis|nucleus|phosphoric ester hydrolase activity|cilium morphogenesis|dephosphorylation|smoothened signaling pathway|phosphatase activity|cellular protein modification process|protein dephosphorylation|phosphoprotein phosphatase activity|peptidyl-tyrosine dephosphorylation|protein tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity - - - - 9:94030794-94109856 32 51 102 153 178 147 0.206345171945221 0.298877195140421 0.592995538614728 0.883948751019094 0.9417300971875 0.888350351438595 0.366072635233457 0.90467639988173 -1.30527190372623 0.000281437143326153 0.00197184334120135 DOWN ENSG00000152926 ZNF117 zinc finger protein 117 [Source:HGNC Symbol;Acc:HGNC:12897] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0008270|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|zinc ion binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 7:64971776-65006684 43 32 45 84 88 149 0.175994263677796 0.119029894493446 0.166054054118006 0.308036756601168 0.295513245163661 0.571535344719506 0.153692737429749 0.391695115494778 -1.34968214397105 0.000281741191432645 0.00197351044791886 DOWN ENSG00000182489 XKRX X-linked Kx blood group related, X-linked [Source:HGNC Symbol;Acc:HGNC:29845] GO:0005623|GO:0016020|GO:0071944|GO:0031224|GO:0005886|GO:0016021 cell|membrane|cell periphery|intrinsic component of membrane|plasma membrane|integral component of membrane - - - - X:100913445-100929433 11 13 24 43 50 42 0.152658882264914 0.163972013279532 0.300295565934351 0.534683242059216 0.569331510602529 0.546273080167975 0.205642153826266 0.550095944276573 -1.41954723880406 0.000283552505026841 0.00198480105159937 DOWN ENSG00000244306 LINC01296 long intergenic non-protein coding RNA 1296 [Source:HGNC Symbol;Acc:HGNC:48904] - - - - - - 14:19284653-19337730 44 73 43 166 150 101 0.365950533993775 0.55179347165549 0.322440460120879 1.23701785108316 1.02359861845646 0.787267076326202 0.413394821923381 1.01596118195527 -1.29725305722293 0.000284011394309567 0.00198708136060882 DOWN ENSG00000085224 ATRX alpha thalassemia/mental retardation syndrome X-linked [Source:HGNC Symbol;Acc:HGNC:886] GO:0032502|GO:0040007|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0032259|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0051641|GO:0003006|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0032504|GO:0016787|GO:0009058|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:0051726|GO:0007049|GO:0006281|GO:0009791|GO:0006725|GO:0009888|GO:0042393|GO:0048468|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043168|GO:0032204|GO:0030900|GO:0001882|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0016817|GO:0007420|GO:0022607|GO:0070603|GO:0032206|GO:0060009|GO:0043231|GO:0000723|GO:0048608|GO:0043169|GO:0060322|GO:0035264|GO:0042592|GO:0007548|GO:0009890|GO:0045787|GO:0003682|GO:0060008|GO:0019904|GO:0006139|GO:0031297|GO:0000790|GO:0008104|GO:0008406|GO:0007154|GO:0007276|GO:0007165|GO:0000166|GO:0048869|GO:0010035|GO:0044249|GO:0000792|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0008584|GO:0090068|GO:0048232|GO:0046872|GO:0005720|GO:0035639|GO:0043412|GO:0046661|GO:0061458|GO:0007417|GO:0010629|GO:0070087|GO:0002064|GO:0051252|GO:0006325|GO:0001883|GO:0010628|GO:0016818|GO:0033260|GO:0006306|GO:0032549|GO:0031981|GO:0005721|GO:0010564|GO:0005654|GO:0006259|GO:0031933|GO:0005694|GO:0000228|GO:0006461|GO:0072520|GO:0034613|GO:0060429|GO:0051054|GO:0035556|GO:0071241|GO:0033043|GO:0035108|GO:0010467|GO:0007399|GO:0035064|GO:0017076|GO:0031328|GO:0009059|GO:0030154|GO:0060173|GO:0016070|GO:0010557|GO:0005634|GO:0006974|GO:0046546|GO:0010638|GO:2001252|GO:0007283|GO:0045893|GO:0072711|GO:0033262|GO:0033365|GO:0032200|GO:0006260|GO:0006334|GO:0000781|GO:0034622|GO:0030855|GO:0045892|GO:0072331|GO:0042770|GO:0032774|GO:0005524|GO:2001141|GO:0034728|GO:0030554|GO:0033044|GO:1902679|GO:0016604|GO:0006304|GO:0006333|GO:0065004|GO:0006275|GO:0006310|GO:0031497|GO:0000784|GO:0035136|GO:0046914|GO:0016568|GO:0045740|GO:0010571|GO:0071103|GO:0016462|GO:0006351|GO:0006355|GO:0000775|GO:0006336|GO:0006323|GO:0045944|GO:0006366|GO:0034502|GO:1903507|GO:0006357|GO:0006261|GO:0032392|GO:1903506|GO:0017111|GO:0016605|GO:0035128|GO:2000105|GO:0006338|GO:0000122|GO:0008270|GO:0030330|GO:0016887|GO:0070198|GO:0032508|GO:0004386|GO:1901581|GO:0003678|GO:0042623|GO:0008094|GO:0015616 developmental process|growth|macromolecular complex|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|methylation|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|cellular localization|developmental process involved in reproduction|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|biosynthetic process|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|regulation of cell cycle|cell cycle|DNA repair|post-embryonic development|cellular aromatic compound metabolic process|tissue development|histone binding|cell development|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|regulation of telomere maintenance|forebrain development|nucleoside binding|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|hydrolase activity, acting on acid anhydrides|brain development|cellular component assembly|SWI/SNF superfamily-type complex|positive regulation of telomere maintenance|Sertoli cell development|intracellular membrane-bounded organelle|telomere maintenance|reproductive structure development|cation binding|head development|multicellular organism growth|homeostatic process|sex differentiation|negative regulation of biosynthetic process|positive regulation of cell cycle|chromatin binding|Sertoli cell differentiation|protein domain specific binding|nucleobase-containing compound metabolic process|replication fork processing|nuclear chromatin|protein localization|gonad development|cell communication|gamete generation|signal transduction|nucleotide binding|cellular developmental process|response to inorganic substance|cellular biosynthetic process|heterochromatin|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gonad development|positive regulation of cell cycle process|male gamete generation|metal ion binding|nuclear heterochromatin|purine ribonucleoside triphosphate binding|macromolecule modification|male sex differentiation|reproductive system development|central nervous system development|negative regulation of gene expression|chromo shadow domain binding|epithelial cell development|regulation of RNA metabolic process|chromatin organization|purine nucleoside binding|positive regulation of gene expression|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nuclear DNA replication|DNA methylation|ribonucleoside binding|nuclear lumen|pericentric heterochromatin|regulation of cell cycle process|nucleoplasm|DNA metabolic process|telomeric heterochromatin|chromosome|nuclear chromosome|protein complex assembly|seminiferous tubule development|cellular protein localization|epithelium development|positive regulation of DNA metabolic process|intracellular signal transduction|cellular response to inorganic substance|regulation of organelle organization|limb morphogenesis|gene expression|nervous system development|methylated histone binding|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|limb development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|cellular response to DNA damage stimulus|development of primary male sexual characteristics|positive regulation of organelle organization|positive regulation of chromosome organization|spermatogenesis|positive regulation of transcription, DNA-templated|cellular response to hydroxyurea|regulation of nuclear cell cycle DNA replication|protein localization to organelle|telomere organization|DNA replication|nucleosome assembly|chromosome, telomeric region|cellular macromolecular complex assembly|epithelial cell differentiation|negative regulation of transcription, DNA-templated|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|ATP binding|regulation of RNA biosynthetic process|nucleosome organization|adenyl nucleotide binding|regulation of chromosome organization|negative regulation of RNA biosynthetic process|nuclear body|DNA modification|chromatin assembly or disassembly|protein-DNA complex assembly|regulation of DNA replication|DNA recombination|chromatin assembly|nuclear chromosome, telomeric region|forelimb morphogenesis|transition metal ion binding|chromatin modification|positive regulation of DNA replication|positive regulation of nuclear cell cycle DNA replication|DNA conformation change|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|chromosome, centromeric region|DNA replication-independent nucleosome assembly|DNA packaging|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|protein localization to chromosome|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|DNA-dependent DNA replication|DNA geometric change|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|PML body|post-embryonic forelimb morphogenesis|positive regulation of DNA-dependent DNA replication|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|DNA damage response, signal transduction by p53 class mediator|ATPase activity|protein localization to chromosome, telomeric region|DNA duplex unwinding|helicase activity|negative regulation of telomeric RNA transcription from RNA pol II promoter|DNA helicase activity|ATPase activity, coupled|DNA-dependent ATPase activity|DNA translocase activity - - - - X:77504878-77786269 720 1255 1875 2425 2497 3087 1.52674093098831 2.41855737231949 3.58466212102848 4.6072545956265 4.34429337166363 6.13476915009928 2.50998680811209 5.02877237246314 -1.00252646952173 0.000284259844635181 0.00198826425753503 DOWN ENSG00000250588 IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough [Source:HGNC Symbol;Acc:HGNC:38842] - - - - - - 3:158962235-159897366 55 85 140 236 299 164 0.43175137215862 0.606420053421238 0.990869718619318 1.65990103978655 1.92580261832305 1.20654778162284 0.676347048066392 1.59741714657748 -1.23990548553548 0.00028431366367713 0.00198826425753503 DOWN ENSG00000237978 KCNMB2-AS1 KCNMB2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51409] - - - - - - 3:178526505-178860405 14 15 16 40 43 42 0.401922135642536 0.391371735326263 0.414143194783854 1.02888392291451 1.01283055214993 1.13001375390267 0.402479021917551 1.05724274298904 -1.39332116371531 0.000289224677052074 0.00201976924180412 DOWN ENSG00000174876 AMY1B amylase, alpha 1B (salivary) [Source:HGNC Symbol;Acc:HGNC:475] GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0071704|GO:0043167|GO:0043227|GO:0016787|GO:0005615|GO:0005515|GO:0016798|GO:0031982|GO:0043169|GO:0005975|GO:0070062|GO:0007586|GO:0046872|GO:0004553|GO:0016160|GO:0004556 extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|organic substance metabolic process|ion binding|membrane-bounded organelle|hydrolase activity|extracellular space|protein binding|hydrolase activity, acting on glycosyl bonds|vesicle|cation binding|carbohydrate metabolic process|extracellular exosome|digestion|metal ion binding|hydrolase activity, hydrolyzing O-glycosyl compounds|amylase activity|alpha-amylase activity K01176 alpha-amylase[3.2.1.1] hsa01100|hsa04970|hsa00500|hsa04973 Metabolic pathways - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Carbohydrate digestion and absorption - Homo sapiens (human) 1:103687415-103696680 20 10 10 2 2 5 0.430403869763371 0.195580474837449 0.194031189524532 0.0385645589332733 0.0353113275995654 0.100851610477333 0.273338511375117 0.0582424990033906 2.23054457573806 0.000289709450133986 0.00202268146031338 UP ENSG00000226816 AC005082.12 - - - - - - - 7:23206013-23208045 8 11 2 1 0 0 0.278341615142804 0.347855753825693 0.062742795864942 0.03116025258279 0 0 0.229646721611146 0.01038675086093 4.4665998558696 0.000290330654226591 0.0020265446226983 UP ENSG00000115109 EPB41L5 erythrocyte membrane protein band 4.1 like 5 [Source:HGNC Symbol;Acc:HGNC:19819] GO:0040011|GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0042995|GO:0030055|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0016049|GO:0044089|GO:0071704|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0031252|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0019222|GO:0051272|GO:0048565|GO:0016337|GO:0001756|GO:0045595|GO:0035239|GO:0009888|GO:0048468|GO:0010718|GO:0035295|GO:0051130|GO:0007275|GO:0010632|GO:0048513|GO:0005924|GO:0030155|GO:0005912|GO:1901890|GO:0051128|GO:2000147|GO:0022607|GO:0007440|GO:0098609|GO:0051098|GO:0045597|GO:0043231|GO:0005737|GO:0007389|GO:0032880|GO:0001726|GO:0071559|GO:0006928|GO:1901888|GO:0031589|GO:0048729|GO:0048598|GO:0045184|GO:0019904|GO:0007162|GO:0008104|GO:0001704|GO:0044092|GO:0051270|GO:0016477|GO:0045785|GO:0008092|GO:0031256|GO:0010634|GO:0031253|GO:0048869|GO:0030029|GO:2000145|GO:0010033|GO:0006996|GO:0009826|GO:0060560|GO:0000902|GO:0010468|GO:0090132|GO:0045216|GO:0055123|GO:2000736|GO:0051100|GO:0002009|GO:0032525|GO:0007010|GO:0007509|GO:0010720|GO:0007498|GO:0002064|GO:0009798|GO:0009880|GO:0030048|GO:0010717|GO:0007492|GO:0007398|GO:0000904|GO:0009790|GO:0030334|GO:0001667|GO:0071560|GO:0070201|GO:0007369|GO:0007160|GO:0034329|GO:0022408|GO:0003002|GO:0022407|GO:0001707|GO:0060485|GO:0016331|GO:0051099|GO:0010810|GO:0070848|GO:0022604|GO:0006931|GO:0030036|GO:0032587|GO:0060429|GO:0006929|GO:0048864|GO:0010467|GO:1903393|GO:0071310|GO:0051894|GO:0010770|GO:0010811|GO:0030154|GO:0030335|GO:0048546|GO:0005856|GO:0005634|GO:0048617|GO:0048332|GO:0005925|GO:2000738|GO:0043393|GO:0001840|GO:0048863|GO:0070252|GO:0000578|GO:0009792|GO:0048319|GO:0030855|GO:0010769|GO:0048339|GO:0034332|GO:0014031|GO:0071363|GO:0010608|GO:0001839|GO:0003382|GO:0061053|GO:0001952|GO:0007044|GO:0032092|GO:0009948|GO:0001954|GO:0010631|GO:0048041|GO:0009952|GO:0070986|GO:0048762|GO:0060972|GO:0048318|GO:0031032|GO:0051893|GO:0042074|GO:0032091|GO:0001837|GO:0008078|GO:0035282|GO:0034333|GO:0003383|GO:0043009|GO:0001701 locomotion|developmental process|growth|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|cell projection|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|cell growth|positive regulation of cellular component biogenesis|organic substance metabolic process|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|cell leading edge|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of cellular component movement|digestive tract development|single organismal cell-cell adhesion|somitogenesis|regulation of cell differentiation|tube morphogenesis|tissue development|cell development|positive regulation of epithelial to mesenchymal transition|tube development|positive regulation of cellular component organization|multicellular organism development|regulation of epithelial cell migration|animal organ development|cell-substrate adherens junction|regulation of cell adhesion|adherens junction|positive regulation of cell junction assembly|regulation of cellular component organization|positive regulation of cell motility|cellular component assembly|foregut morphogenesis|cell-cell adhesion|regulation of binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|regulation of protein localization|ruffle|response to transforming growth factor beta|movement of cell or subcellular component|regulation of cell junction assembly|cell-substrate adhesion|tissue morphogenesis|embryonic morphogenesis|establishment of protein localization|protein domain specific binding|negative regulation of cell adhesion|protein localization|formation of primary germ layer|negative regulation of molecular function|regulation of cellular component movement|cell migration|positive regulation of cell adhesion|cytoskeletal protein binding|leading edge membrane|positive regulation of epithelial cell migration|cell projection membrane|cellular developmental process|actin filament-based process|regulation of cell motility|response to organic substance|organelle organization|unidimensional cell growth|developmental growth involved in morphogenesis|cell morphogenesis|regulation of gene expression|epithelium migration|cell-cell junction organization|digestive system development|regulation of stem cell differentiation|negative regulation of binding|morphogenesis of an epithelium|somite rostral/caudal axis specification|cytoskeleton organization|mesoderm migration involved in gastrulation|positive regulation of cell development|mesoderm development|epithelial cell development|axis specification|embryonic pattern specification|actin filament-based movement|regulation of epithelial to mesenchymal transition|endoderm development|ectoderm development|cell morphogenesis involved in differentiation|embryo development|regulation of cell migration|ameboidal-type cell migration|cellular response to transforming growth factor beta stimulus|regulation of establishment of protein localization|gastrulation|cell-matrix adhesion|cell junction assembly|negative regulation of cell-cell adhesion|regionalization|regulation of cell-cell adhesion|mesoderm formation|mesenchyme development|morphogenesis of embryonic epithelium|positive regulation of binding|regulation of cell-substrate adhesion|response to growth factor|regulation of cell morphogenesis|substrate-dependent cell migration, cell attachment to substrate|actin cytoskeleton organization|ruffle membrane|epithelium development|substrate-dependent cell migration|stem cell development|gene expression|positive regulation of adherens junction organization|cellular response to organic substance|positive regulation of focal adhesion assembly|positive regulation of cell morphogenesis involved in differentiation|positive regulation of cell-substrate adhesion|cell differentiation|positive regulation of cell migration|digestive tract morphogenesis|cytoskeleton|nucleus|embryonic foregut morphogenesis|mesoderm morphogenesis|focal adhesion|positive regulation of stem cell differentiation|regulation of protein binding|neural plate development|stem cell differentiation|actin-mediated cell contraction|embryonic axis specification|embryo development ending in birth or egg hatching|axial mesoderm morphogenesis|epithelial cell differentiation|regulation of cell morphogenesis involved in differentiation|paraxial mesoderm development|adherens junction organization|mesenchymal cell development|cellular response to growth factor stimulus|posttranscriptional regulation of gene expression|neural plate morphogenesis|epithelial cell morphogenesis|somite development|regulation of cell-matrix adhesion|cell-substrate junction assembly|positive regulation of protein binding|anterior/posterior axis specification|positive regulation of cell-matrix adhesion|epithelial cell migration|focal adhesion assembly|anterior/posterior pattern specification|left/right axis specification|mesenchymal cell differentiation|left/right pattern formation|axial mesoderm development|actomyosin structure organization|regulation of focal adhesion assembly|cell migration involved in gastrulation|negative regulation of protein binding|epithelial to mesenchymal transition|mesodermal cell migration|segmentation|adherens junction assembly|apical constriction|chordate embryonic development|in utero embryonic development - - - - 2:120013005-120179119 81 111 277 355 364 513 0.353904680239123 0.440761022571623 1.09117273247624 1.38971373168547 1.30487274792599 2.10061080299839 0.628612811762329 1.59839909420328 -1.34638408955525 0.000290565595370614 0.0020272365702721 DOWN ENSG00000065665 SEC61A2 Sec61 translocon alpha 2 subunit [Source:HGNC Symbol;Acc:HGNC:17702] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0044877|GO:0050794|GO:0019882|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0019884|GO:0006810|GO:0043021|GO:0033554|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0048002|GO:0016021|GO:0019538|GO:0010033|GO:0005829|GO:0030968|GO:0015031|GO:0006986|GO:0043022|GO:0002474|GO:0044267|GO:0071310|GO:0035967|GO:0034976|GO:0034620|GO:0042590|GO:0036498|GO:0002479 immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|antigen processing and presentation|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|antigen processing and presentation of exogenous antigen|transport|ribonucleoprotein complex binding|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|endoplasmic reticulum|antigen processing and presentation of peptide antigen|integral component of membrane|protein metabolic process|response to organic substance|cytosol|endoplasmic reticulum unfolded protein response|protein transport|response to unfolded protein|ribosome binding|antigen processing and presentation of peptide antigen via MHC class I|cellular protein metabolic process|cellular response to organic substance|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|cellular response to unfolded protein|antigen processing and presentation of exogenous peptide antigen via MHC class I|IRE1-mediated unfolded protein response|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent K10956 protein transport protein SEC61 subunit alpha[-] hsa04141|hsa04145|hsa05110|hsa03060 Protein processing in endoplasmic reticulum - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Vibrio cholerae infection - Homo sapiens (human)|Protein export - Homo sapiens (human) 10:12129637-12169961 60 67 69 144 152 129 0.509815322490882 0.517390950625288 0.528598854683799 1.09627894105994 1.05967262267771 1.02725752612392 0.518601709266656 1.06106969662052 -1.03282055682845 0.000292137911771868 0.00203582754856147 DOWN ENSG00000048540 LMO3 LIM domain only 3 [Source:HGNC Symbol;Acc:HGNC:6643] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0023057|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0019222|GO:0045595|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0045597|GO:0043169|GO:0005737|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0000165|GO:0032268|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0043412|GO:0051252|GO:0036211|GO:0032269|GO:0035358|GO:0035360|GO:0045600|GO:0033143|GO:0014070|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:1902532|GO:0045598|GO:0051246|GO:0009059|GO:0030154|GO:0009755|GO:1902531|GO:0016070|GO:0032870|GO:0048545|GO:0030522|GO:0043401|GO:0045444|GO:2000324|GO:0043408|GO:0032774|GO:0035357|GO:2001141|GO:0016310|GO:0070371|GO:0071383|GO:0071407|GO:0030518|GO:0046914|GO:0043409|GO:0006464|GO:0071396|GO:0006351|GO:0006355|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0042326|GO:0001933|GO:0070372|GO:0070373|GO:0008270|GO:0042921 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|negative regulation of signaling|biosynthetic process|regulation of developmental process|intracellular|protein binding|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|positive regulation of cell differentiation|cation binding|cytoplasm|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|macromolecule modification|regulation of RNA metabolic process|protein modification process|negative regulation of cellular protein metabolic process|regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of fat cell differentiation|regulation of intracellular steroid hormone receptor signaling pathway|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|negative regulation of intracellular signal transduction|regulation of fat cell differentiation|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|regulation of intracellular signal transduction|RNA metabolic process|cellular response to hormone stimulus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|fat cell differentiation|positive regulation of glucocorticoid receptor signaling pathway|regulation of MAPK cascade|RNA biosynthetic process|peroxisome proliferator activated receptor signaling pathway|regulation of RNA biosynthetic process|phosphorylation|ERK1 and ERK2 cascade|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|intracellular steroid hormone receptor signaling pathway|transition metal ion binding|negative regulation of MAPK cascade|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|negative regulation of ERK1 and ERK2 cascade|zinc ion binding|glucocorticoid receptor signaling pathway - - - - 12:16548373-16610594 1 0 1 7 13 4 0.00218753302697415 0 0.00197046917526567 0.0137135675159759 0.0233222018702622 0.00819607361702851 0.00138600073407994 0.0150772810010889 -3.44337635337484 0.000294831991725997 0.00205038218425244 DOWN ENSG00000166762 CATSPER2 cation channel, sperm associated 2 [Source:HGNC Symbol;Acc:HGNC:18810] GO:0040011|GO:0032502|GO:0032991|GO:0000003|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0005488|GO:0042995|GO:0022857|GO:0050794|GO:0044702|GO:0019953|GO:0048870|GO:0071944|GO:0032504|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0048609|GO:0042391|GO:0006810|GO:0098797|GO:0007275|GO:0031514|GO:0030317|GO:0006928|GO:0022891|GO:0008037|GO:0035036|GO:1902495|GO:0055085|GO:0007276|GO:0009566|GO:0048869|GO:0016021|GO:0048232|GO:0051899|GO:0001508|GO:0009988|GO:0015267|GO:0006811|GO:0007338|GO:0015075|GO:0005891|GO:0034765|GO:0034702|GO:0043269|GO:0030154|GO:0034220|GO:0036128|GO:0007283|GO:0098655|GO:0005216|GO:0086010|GO:0034703|GO:0006812|GO:0008324|GO:0005244|GO:0034704|GO:0022890|GO:0030001|GO:0005261|GO:0022839|GO:0005262|GO:0070588|GO:0022843|GO:0005227|GO:0046873|GO:0006816|GO:0015085|GO:0005245 locomotion|developmental process|macromolecular complex|reproduction|transporter activity|cell|membrane|cellular process|reproductive process|binding|cell projection|transmembrane transporter activity|regulation of cellular process|single organism reproductive process|sexual reproduction|cell motility|cell periphery|multicellular organism reproduction|intrinsic component of membrane|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|multicellular organismal reproductive process|regulation of membrane potential|transport|plasma membrane protein complex|multicellular organism development|motile cilium|sperm motility|movement of cell or subcellular component|substrate-specific transmembrane transporter activity|cell recognition|sperm-egg recognition|transmembrane transporter complex|transmembrane transport|gamete generation|fertilization|cellular developmental process|integral component of membrane|male gamete generation|membrane depolarization|action potential|cell-cell recognition|channel activity|ion transport|single fertilization|ion transmembrane transporter activity|voltage-gated calcium channel complex|regulation of ion transmembrane transport|ion channel complex|regulation of ion transport|cell differentiation|ion transmembrane transport|CatSper complex|spermatogenesis|cation transmembrane transport|ion channel activity|membrane depolarization during action potential|cation channel complex|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|calcium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|ion gated channel activity|calcium channel activity|calcium ion transmembrane transport|voltage-gated cation channel activity|calcium activated cation channel activity|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity|voltage-gated calcium channel activity - - - - 15:43628503-43668118 13 9 23 29 53 71 0.0778636281795592 0.0489937462632934 0.124205065346955 0.155631893860473 0.260458448005522 0.398548014887485 0.0836874799299359 0.271546118917827 -1.69811353408114 0.000295070399628655 0.00205147454832647 DOWN ENSG00000069424 KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 [Source:HGNC Symbol;Acc:HGNC:6229] GO:0032502|GO:0032991|GO:0005215|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0003824|GO:0019898|GO:0042995|GO:0022857|GO:0016491|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0071944|GO:0031224|GO:0016247|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0060341|GO:0009898|GO:0006725|GO:0006810|GO:1901360|GO:0098797|GO:0007275|GO:0048513|GO:0050877|GO:0034641|GO:0005874|GO:0044281|GO:0019637|GO:0046483|GO:0016614|GO:0005887|GO:0005737|GO:0007267|GO:0032880|GO:0031234|GO:0098562|GO:0043005|GO:0015459|GO:0019897|GO:0014069|GO:0051186|GO:0022891|GO:0006139|GO:0031226|GO:0055086|GO:0008104|GO:1902495|GO:0007154|GO:0055085|GO:0044306|GO:0071804|GO:0048869|GO:0016021|GO:0055114|GO:0005829|GO:0044224|GO:0050905|GO:0030424|GO:0030097|GO:0015267|GO:0006811|GO:0044304|GO:0043679|GO:0015075|GO:0008076|GO:0016616|GO:0034765|GO:0034702|GO:0043269|GO:0034613|GO:1990031|GO:0006796|GO:0070995|GO:0071805|GO:0030154|GO:1903827|GO:0005856|GO:0034220|GO:2000008|GO:0098655|GO:0005216|GO:1901379|GO:0009117|GO:0034703|GO:0006812|GO:0034394|GO:0015630|GO:0002244|GO:0004033|GO:0008324|GO:0005244|GO:0043266|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0007268|GO:0006739|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249 developmental process|macromolecular complex|transporter activity|immune system process|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|binding|catalytic activity|extrinsic component of membrane|cell projection|transmembrane transporter activity|oxidoreductase activity|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cell periphery|intrinsic component of membrane|channel regulator activity|intracellular|immune system development|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of cellular localization|cytoplasmic side of plasma membrane|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|plasma membrane protein complex|multicellular organism development|animal organ development|neurological system process|cellular nitrogen compound metabolic process|microtubule|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|oxidoreductase activity, acting on CH-OH group of donors|integral component of plasma membrane|cytoplasm|cell-cell signaling|regulation of protein localization|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|neuron projection|potassium channel regulator activity|extrinsic component of plasma membrane|postsynaptic density|cofactor metabolic process|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|nucleobase-containing small molecule metabolic process|protein localization|transmembrane transporter complex|cell communication|transmembrane transport|neuron projection terminus|cellular potassium ion transport|cellular developmental process|integral component of membrane|oxidation-reduction process|cytosol|juxtaparanode region of axon|neuromuscular process|axon|hemopoiesis|channel activity|ion transport|main axon|axon terminus|ion transmembrane transporter activity|voltage-gated potassium channel complex|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|regulation of ion transmembrane transport|ion channel complex|regulation of ion transport|cellular protein localization|pinceau fiber|phosphate-containing compound metabolic process|NADPH oxidation|potassium ion transmembrane transport|cell differentiation|regulation of cellular protein localization|cytoskeleton|ion transmembrane transport|regulation of protein localization to cell surface|cation transmembrane transport|ion channel activity|regulation of potassium ion transmembrane transport|nucleotide metabolic process|cation channel complex|cation transport|protein localization to cell surface|microtubule cytoskeleton|hematopoietic progenitor cell differentiation|aldo-keto reductase (NADP) activity|cation transmembrane transporter activity|voltage-gated ion channel activity|regulation of potassium ion transport|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|synaptic transmission|NADP metabolic process|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity - - - - 1:5991466-6101193 95 105 178 305 219 338 0.380994821087749 0.382707628016791 0.643623214763582 1.09595684339824 0.720624982093971 1.27040495564604 0.469108554622707 1.02899559371275 -1.1332430893979 0.00029638536180282 0.0020591781687832 DOWN ENSG00000265194 RP11-70L8.4 - - - - - - - 9:21858910-21861926 3 7 11 30 28 19 0.0703459792240451 0.149168557908968 0.232524096051369 0.6302159297292 0.538638686169927 0.41749094984337 0.150679544394794 0.528781855247499 -1.81118909652645 0.000297943686010232 0.00206856065166267 DOWN ENSG00000258311 RP11-644F5.10 - GO:0032991|GO:0005623|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0043234|GO:0006810|GO:0043231|GO:0005737|GO:0051649|GO:0005829|GO:0046907|GO:0005739|GO:0031083|GO:0016197 macromolecular complex|cell|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein complex|transport|intracellular membrane-bounded organelle|cytoplasm|establishment of localization in cell|cytosol|intracellular transport|mitochondrion|BLOC-1 complex|endosomal transport - - - - 12:55716036-55724703 33 55 45 15 22 22 0.477851989501084 0.723814132857051 0.587494824426101 0.194612227225486 0.261385448252887 0.298566622018629 0.596386982261412 0.251521432499001 1.24556742792777 0.000300074800794267 0.00208142033060224 UP ENSG00000169105 CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 [Source:HGNC Symbol;Acc:HGNC:24464] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0006082|GO:0043168|GO:0044281|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0070062|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0034645|GO:0030204|GO:0009100|GO:0042301|GO:1901137|GO:0008146|GO:0000139|GO:0030205|GO:0009059|GO:0016051|GO:0009101|GO:0030208|GO:0001537|GO:0006024|GO:0006029|GO:0019752|GO:0030203|GO:0050655|GO:0032787|GO:0030166|GO:0050651 cell|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|organic acid metabolic process|anion binding|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|extracellular exosome|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|cellular macromolecule biosynthetic process|chondroitin sulfate metabolic process|glycoprotein metabolic process|phosphate ion binding|carbohydrate derivative biosynthetic process|sulfotransferase activity|Golgi membrane|dermatan sulfate metabolic process|macromolecule biosynthetic process|carbohydrate biosynthetic process|glycoprotein biosynthetic process|dermatan sulfate biosynthetic process|N-acetylgalactosamine 4-O-sulfotransferase activity|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|carboxylic acid metabolic process|glycosaminoglycan metabolic process|dermatan sulfate proteoglycan metabolic process|monocarboxylic acid metabolic process|proteoglycan biosynthetic process|dermatan sulfate proteoglycan biosynthetic process K08105 dermatan 4-sulfotransferase 1[2.8.2.35] hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate - Homo sapiens (human) 15:40470998-40474571 88 86 85 198 239 149 1.12320797243488 0.997601584049075 0.978160871316547 2.26433778214886 2.50290958024542 1.78236112645024 1.03299014260017 2.18320282961484 -1.07961968235666 0.000300364750200173 0.00208294756155075 DOWN ENSG00000276445 LLNLR-268E12.1 - - - - - - - 19:39812972-39813555 18 25 17 10 5 0 2.18025752399978 2.75207701478529 1.85649573590284 1.08528857203484 0.496917628808041 0 2.26294342489597 0.527402066947627 2.10122538630236 0.00030197540756432 0.00209314460585679 UP ENSG00000072832 CRMP1 collapsin response mediator protein 1 [Source:HGNC Symbol;Acc:HGNC:2365] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0009605|GO:0016787|GO:0005622|GO:0005515|GO:0048856|GO:0006935|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0005737|GO:0016810|GO:0006928|GO:0006139|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0005829|GO:0031175|GO:0007010|GO:0005815|GO:0000904|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0000226|GO:0005856|GO:0005819|GO:0048666|GO:0030182|GO:0007411|GO:0061564|GO:0015630|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699 locomotion|developmental process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|response to external stimulus|hydrolase activity|intracellular|protein binding|anatomical structure development|chemotaxis|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cytoplasm|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|movement of cell or subcellular component|nucleobase-containing compound metabolic process|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|cytosol|neuron projection development|cytoskeleton organization|microtubule organizing center|cell morphogenesis involved in differentiation|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|spindle|neuron development|neuron differentiation|axon guidance|axon development|microtubule cytoskeleton|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons - - - - 4:5748084-5893058 1 1 2 11 15 5 0.00788135576596657 0.00716312804732591 0.014206047888788 0.0776430916103307 0.0969595373283982 0.0369193945471647 0.00975017723402683 0.0705073411619645 -2.85427312863386 0.000302341973500313 0.0020944623832939 DOWN ENSG00000187951 ARHGAP11B Rho GTPase activating protein 11B [Source:HGNC Symbol;Acc:HGNC:15782] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0023051|GO:0005622|GO:0048856|GO:0007275|GO:0048513|GO:0030900|GO:0007420|GO:0005737|GO:0060322|GO:0021987|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0021543|GO:0021537|GO:0005829|GO:0007417|GO:0035556|GO:0007399|GO:1902531|GO:0051056|GO:0007264 developmental process|signaling|cell|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of signaling|intracellular|anatomical structure development|multicellular organism development|animal organ development|forebrain development|brain development|cytoplasm|head development|cerebral cortex development|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|pallium development|telencephalon development|cytosol|central nervous system development|intracellular signal transduction|nervous system development|regulation of intracellular signal transduction|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 15:30624494-30772993 76 135 161 254 261 299 0.494892371154942 0.798933646813242 0.945229932084396 1.48193165943475 1.39445224036514 1.82471747714276 0.74635198335086 1.56703379231422 -1.07010821283592 0.000303461124247882 0.00210002976432459 DOWN ENSG00000125695 RP11-51F16.8 - GO:0005623|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0012505|GO:0043231|GO:0043169|GO:0005737|GO:0005783|GO:0046872|GO:0005509 cell|binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|endomembrane system|intracellular membrane-bounded organelle|cation binding|cytoplasm|endoplasmic reticulum|metal ion binding|calcium ion binding - - - - 17:63702845-63752097 27 14 62 11 9 0 0.89751202585705 0.422942776835983 1.85813239054923 0.327611522353928 0.245458911120037 0 1.05952906441409 0.191023477824655 2.47160129412339 0.000304920725759912 0.00210866419894288 UP ENSG00000223374 AC005104.3 - - - - - - - 2:241351340-241353104 26 22 19 5 6 11 4.16094773212939 3.19982046547405 2.74151496325947 0.716905438751473 0.787794120948676 1.64980478711607 3.36742772028764 1.05150144893874 1.67919614141737 0.000306702144121923 0.0021200013453614 UP ENSG00000109265 KIAA1211 KIAA1211 [Source:HGNC Symbol;Acc:HGNC:29219] - - - - - - 4:56049073-56328625 0 0 5 13 7 20 0 0 0.043780981162529 0.113129071094718 0.0557830878818711 0.182048049025836 0.0145936603875097 0.116986736000808 -3.00293127470467 0.00030699756125734 0.00212155212818904 DOWN ENSG00000242515 UGT1A10 UDP glucuronosyltransferase 1 family, polypeptide A10 [Source:HGNC Symbol;Acc:HGNC:12531] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0042802|GO:0044262|GO:0044255|GO:0006082|GO:0009410|GO:0044281|GO:0043231|GO:0019899|GO:0005737|GO:0005975|GO:0046983|GO:0044092|GO:0009812|GO:0006629|GO:0005783|GO:0016757|GO:0042180|GO:0006805|GO:0050790|GO:0045833|GO:0043086|GO:0016021|GO:0031324|GO:0031323|GO:0006109|GO:0046982|GO:0008194|GO:0006631|GO:0052696|GO:0052697|GO:0051552|GO:0016758|GO:0071466|GO:0005996|GO:0010565|GO:0019900|GO:0009813|GO:0019216|GO:0045922|GO:0042803|GO:0019217|GO:2001030|GO:0015020|GO:1904224|GO:0019752|GO:0019901|GO:0005080|GO:0032787|GO:0052695 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|identical protein binding|cellular carbohydrate metabolic process|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|small molecule metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|carbohydrate metabolic process|protein dimerization activity|negative regulation of molecular function|flavonoid metabolic process|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular ketone metabolic process|xenobiotic metabolic process|regulation of catalytic activity|negative regulation of lipid metabolic process|negative regulation of catalytic activity|integral component of membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of carbohydrate metabolic process|protein heterodimerization activity|UDP-glycosyltransferase activity|fatty acid metabolic process|flavonoid glucuronidation|xenobiotic glucuronidation|flavone metabolic process|transferase activity, transferring hexosyl groups|cellular response to xenobiotic stimulus|monosaccharide metabolic process|regulation of cellular ketone metabolic process|kinase binding|flavonoid biosynthetic process|regulation of lipid metabolic process|negative regulation of fatty acid metabolic process|protein homodimerization activity|regulation of fatty acid metabolic process|negative regulation of cellular glucuronidation|glucuronosyltransferase activity|negative regulation of glucuronosyltransferase activity|carboxylic acid metabolic process|protein kinase binding|protein kinase C binding|monocarboxylic acid metabolic process|cellular glucuronidation K00699 glucuronosyltransferase[2.4.1.17] hsa01100|hsa05204|hsa00980|hsa00982|hsa00830|hsa00140|hsa00500|hsa00983|hsa00860|hsa00040|hsa00053 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Ascorbate and aldarate metabolism - Homo sapiens (human) 2:233636454-233773305 0 0 0 0 150 0 0 0 0 0 2.15861796428768 0 0 0.719539321429227 -Inf 0.000309838965455417 0.00213772416794685 DOWN ENSG00000178146 RP1-232L22__B.1 - - - - - - - X:101778969-101780538 5 3 13 25 24 29 0.225287226251767 0.122861357258012 0.528077262280514 1.00922882551901 0.887220540468233 1.22452112497136 0.292075281930098 1.0403234969862 -1.83262004134145 0.000311312817397242 0.00214640481537581 DOWN ENSG00000251634 RP11-1280N14.3 - - - - - - - 5:71102898-71128753 2 1 0 7 14 8 0.0496201774452228 0.0225597077295473 0 0.155606422006952 0.285000511430142 0.186024721070553 0.0240599617249234 0.208877218169216 -3.11794889649138 0.000311621492089201 0.00214803694870261 DOWN ENSG00000135437 RDH5 retinol dehydrogenase 5 (11-cis/9-cis) [Source:HGNC Symbol;Acc:HGNC:9940] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0051606|GO:0016491|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0009628|GO:0044237|GO:0042445|GO:0044297|GO:0043227|GO:0009605|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0044255|GO:0009314|GO:0050877|GO:0044281|GO:0016614|GO:0009582|GO:0043231|GO:0005737|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0010817|GO:0055114|GO:0009583|GO:0006720|GO:0006066|GO:0042572|GO:0007602|GO:0007600|GO:0016616|GO:0005788|GO:0009416|GO:0004745|GO:0050953|GO:0009584|GO:0007603|GO:0016101|GO:0007601|GO:0001523 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|detection of stimulus|oxidoreductase activity|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|hormone metabolic process|cell body|membrane-bounded organelle|response to external stimulus|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|response to radiation|neurological system process|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|detection of abiotic stimulus|intracellular membrane-bounded organelle|cytoplasm|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|regulation of hormone levels|oxidation-reduction process|detection of light stimulus|isoprenoid metabolic process|alcohol metabolic process|retinol metabolic process|phototransduction|sensory perception|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|endoplasmic reticulum lumen|response to light stimulus|retinol dehydrogenase activity|sensory perception of light stimulus|detection of visible light|phototransduction, visible light|diterpenoid metabolic process|visual perception|retinoid metabolic process K00061 11-cis-retinol dehydrogenase[1.1.1.315] hsa00830 Retinol metabolism - Homo sapiens (human) 12:55720367-55724705 19 23 21 7 9 7 0.181986570953228 0.200221851384762 0.181354870379704 0.0600722964308491 0.0707293923985699 0.0628396390513783 0.187854430905898 0.0645471092935991 1.54119075330515 0.000313156394468847 0.00215662537496493 UP ENSG00000197472 ZNF695 zinc finger protein 695 [Source:HGNC Symbol;Acc:HGNC:30954] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 1:246945547-247008093 149 143 117 76 86 49 1.98639235514386 1.73258850772047 1.40630705102358 0.907793524968583 0.940687350611342 0.612217230307312 1.7084293046293 0.820232701962412 1.05856538088616 0.000313136428950032 0.00215662537496493 UP ENSG00000278703 RP11-706P11.2 - - - - - - - 18:57588611-57589091 14 10 5 2 0 2 2.05891089859295 1.3365343467582 0.662904128496255 0.263537848677067 0 0.275616404896957 1.3527831246158 0.179718084524675 2.91212307237245 0.000314682256312513 0.00216663378227716 UP ENSG00000257167 TMPO-AS1 TMPO antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44158] - - - - - - 12:98512973-98516422 23 24 26 53 79 55 0.397306798347043 0.376775396800407 0.404923712713263 0.820290356738503 1.11966272363861 0.890388057698878 0.393001969286904 0.94344704602533 -1.26340500255926 0.000315108549789729 0.00216877292678034 DOWN ENSG00000073910 FRY FRY microtubule binding protein [Source:HGNC Symbol;Acc:HGNC:20367] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0009653|GO:0016043|GO:0030427|GO:0071944|GO:0030234|GO:0005622|GO:0048856|GO:0019222|GO:0004857|GO:0048468|GO:0005938|GO:0007275|GO:0005737|GO:0044092|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0030029|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0032268|GO:0000902|GO:0031175|GO:0043412|GO:0007010|GO:0005815|GO:0036211|GO:0032269|GO:0030036|GO:0044267|GO:0007399|GO:0051246|GO:0030154|GO:0005856|GO:0000922|GO:0005819|GO:0048666|GO:0030182|GO:0031532|GO:0015630|GO:0022008|GO:0006464|GO:0007015|GO:0048699|GO:0090311|GO:1904428|GO:0090527|GO:0090043|GO:0006476|GO:0090042 developmental process|cell|cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell periphery|enzyme regulator activity|intracellular|anatomical structure development|regulation of metabolic process|enzyme inhibitor activity|cell development|cell cortex|multicellular organism development|cytoplasm|negative regulation of molecular function|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|macromolecule modification|cytoskeleton organization|microtubule organizing center|protein modification process|negative regulation of cellular protein metabolic process|actin cytoskeleton organization|cellular protein metabolic process|nervous system development|regulation of protein metabolic process|cell differentiation|cytoskeleton|spindle pole|spindle|neuron development|neuron differentiation|actin cytoskeleton reorganization|microtubule cytoskeleton|neurogenesis|cellular protein modification process|actin filament organization|generation of neurons|regulation of protein deacetylation|negative regulation of tubulin deacetylation|actin filament reorganization|regulation of tubulin deacetylation|protein deacetylation|tubulin deacetylation - - - - 13:32031300-32299122 43 45 116 149 129 543 0.138027356679373 0.131277352553251 0.335710567979197 0.428527408742758 0.339742322586614 1.63351058729077 0.201671759070607 0.800593439540047 -1.98906072206528 0.000315401659697046 0.00217008553781876 DOWN ENSG00000212127 TAS2R14 taste 2 receptor member 14 [Source:HGNC Symbol;Acc:HGNC:14920] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0051606|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0050877|GO:0004888|GO:0050906|GO:0007154|GO:0009593|GO:0007165|GO:0016021|GO:0007186|GO:0050907|GO:0007600|GO:0004930|GO:0008527|GO:0050912|GO:0007606|GO:0050909|GO:0033038|GO:0001580|GO:0050913 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|detection of stimulus|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|neurological system process|transmembrane signaling receptor activity|detection of stimulus involved in sensory perception|cell communication|detection of chemical stimulus|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|detection of chemical stimulus involved in sensory perception|sensory perception|G-protein coupled receptor activity|taste receptor activity|detection of chemical stimulus involved in sensory perception of taste|sensory perception of chemical stimulus|sensory perception of taste|bitter taste receptor activity|detection of chemical stimulus involved in sensory perception of bitter taste|sensory perception of bitter taste - - - - 12:10937406-11171573 3 0 3 8 14 18 0.0602936986701545 0 0.054346813015134 0.144047392288261 0.230834221047538 0.339001264289696 0.0382135038950962 0.237960959208498 -2.63857044552624 0.00031584215904049 0.00217261562580525 DOWN ENSG00000244625 MIATNB MIAT neighbor (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:50731] - - - - - - 22:26672767-26780207 7 8 6 37 23 20 0.114041471928053 0.118447355281565 0.0881318083786921 0.540072632228193 0.307432754709989 0.305356043541033 0.106873545196103 0.384287143493072 -1.84627992955654 0.000316722689823048 0.00217766908843328 DOWN ENSG00000170965 PLAC1 placenta specific 1 [Source:HGNC Symbol;Acc:HGNC:9044] GO:0032502|GO:0040007|GO:0000003|GO:0005576|GO:0022414|GO:0044702|GO:0003006|GO:0048589|GO:0048856|GO:0001890|GO:0009888|GO:0007275|GO:0048513|GO:0048608|GO:0090214|GO:0048568|GO:0001892|GO:0061458|GO:0060712|GO:0009790|GO:0009792|GO:0043009|GO:0001701 developmental process|growth|reproduction|extracellular region|reproductive process|single organism reproductive process|developmental process involved in reproduction|developmental growth|anatomical structure development|placenta development|tissue development|multicellular organism development|animal organ development|reproductive structure development|spongiotrophoblast layer developmental growth|embryonic organ development|embryonic placenta development|reproductive system development|spongiotrophoblast layer development|embryo development|embryo development ending in birth or egg hatching|chordate embryonic development|in utero embryonic development - - - - X:134565838-134764322 2 4 8 23 14 20 0.0442361244203659 0.0804093834635015 0.159544845520234 0.455824750109811 0.254076440927872 0.414589099767094 0.0947301178013671 0.374830096934926 -1.98434171500822 0.000319144436350792 0.00219280506393936 DOWN ENSG00000019995 ZRANB1 zinc finger, RAN-binding domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18224] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0016787|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0032182|GO:0051128|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0006928|GO:0009966|GO:0010646|GO:0007154|GO:0016477|GO:0007165|GO:0048869|GO:0009967|GO:0019538|GO:0006996|GO:0030111|GO:0000902|GO:0036459|GO:0046872|GO:0007166|GO:0043412|GO:0007010|GO:0030163|GO:0043130|GO:0044265|GO:0036211|GO:0031981|GO:0006508|GO:0005654|GO:0022604|GO:0044267|GO:0030177|GO:0005634|GO:0016055|GO:0044257|GO:0051603|GO:0070646|GO:0046914|GO:0004843|GO:0031593|GO:0008234|GO:0006464|GO:0071947|GO:0019941|GO:0016579|GO:0070530|GO:0008270|GO:0006511|GO:0070536|GO:0035523|GO:1990168 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|hydrolase activity|regulation of developmental process|intracellular|protein binding|anatomical structure development|ubiquitin-like protein binding|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|cell communication|cell migration|signal transduction|cellular developmental process|positive regulation of signal transduction|protein metabolic process|organelle organization|regulation of Wnt signaling pathway|cell morphogenesis|thiol-dependent ubiquitinyl hydrolase activity|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|cytoskeleton organization|protein catabolic process|ubiquitin binding|cellular macromolecule catabolic process|protein modification process|nuclear lumen|proteolysis|nucleoplasm|regulation of cell morphogenesis|cellular protein metabolic process|positive regulation of Wnt signaling pathway|nucleus|Wnt signaling pathway|cellular protein catabolic process|proteolysis involved in cellular protein catabolic process|protein modification by small protein removal|transition metal ion binding|thiol-dependent ubiquitin-specific protease activity|polyubiquitin binding|cysteine-type peptidase activity|cellular protein modification process|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|modification-dependent protein catabolic process|protein deubiquitination|K63-linked polyubiquitin binding|zinc ion binding|ubiquitin-dependent protein catabolic process|protein K63-linked deubiquitination|protein K29-linked deubiquitination|protein K33-linked deubiquitination - - - - 10:124942123-124988189 100 130 196 336 267 307 1.14981918068287 1.35847679946018 2.0318862889446 3.46151839654811 2.51888781045104 3.30823511605558 1.51339408969588 3.09621377435158 -1.03271736801013 0.000319454128851192 0.00219442787913564 DOWN ENSG00000244932 RP11-529F4.1 - - - - - - - 3:129381298-129394149 7 5 7 20 24 23 0.957771897701362 0.62179291112808 0.863468065377419 2.45174648728172 2.69426740529038 2.94929147763776 0.814344291402287 2.69843512340329 -1.72841222564936 0.000320745003067568 0.00220278843376562 DOWN ENSG00000280184 AL023806.1 - - - - - - - 6:145789760-145791832 13 23 23 6 6 7 0.443593559479303 0.713284308961152 0.707603387239528 0.183446751394601 0.167971539536573 0.223864319534215 0.621493751893328 0.19176087015513 1.69643152675796 0.000322151168540783 0.00221193674922184 UP ENSG00000237501 RP11-816B4.1 - - - - - - - 3:172830981-172831229 4 6 6 0 0 1 1.13628213571349 1.54909161636312 1.53682053004129 0 0 0.26620781276192 1.4073980940393 0.0887359375873067 3.98736814737659 0.000323185473468771 0.00221852819612249 UP ENSG00000264006 AKR1C8P aldo-keto reductase family 1, member C8, pseudogene [Source:HGNC Symbol;Acc:HGNC:23469] - - - - - - 10:5154143-5185187 0 2 0 11 6 6 0 0.0536174329266635 0 0.290724486892894 0.145206422626904 0.165881980407302 0.0178724776422212 0.200604296642367 -3.48854095403191 0.000324766486254713 0.00222835639637973 DOWN ENSG00000136244 IL6 interleukin 6 [Source:HGNC Symbol;Acc:HGNC:6018] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0042752|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0007622|GO:0050794|GO:0045321|GO:0040012|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0007623|GO:0048520|GO:0071704|GO:0050900|GO:0006955|GO:0009628|GO:0009986|GO:0051051|GO:0044237|GO:0051641|GO:0050795|GO:0001776|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0051707|GO:0010888|GO:0007155|GO:0044708|GO:0071944|GO:0002262|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0045058|GO:0048646|GO:0019222|GO:0048514|GO:0060341|GO:0008284|GO:0001818|GO:0044262|GO:0051272|GO:1903409|GO:0042127|GO:0002250|GO:1903706|GO:0051969|GO:0050817|GO:0016337|GO:0010883|GO:0002286|GO:0008360|GO:0006935|GO:0006959|GO:0045595|GO:0009897|GO:0006725|GO:0051602|GO:0051971|GO:0070661|GO:0009888|GO:0002685|GO:0048468|GO:0050867|GO:0006810|GO:0009612|GO:1901360|GO:0001568|GO:0010941|GO:0001562|GO:0009991|GO:0098797|GO:0007275|GO:0045596|GO:0048513|GO:0050877|GO:0070489|GO:0005102|GO:0034641|GO:0044281|GO:0032940|GO:0006952|GO:0030155|GO:2001057|GO:0031325|GO:0046483|GO:0051128|GO:0042092|GO:0043368|GO:2000147|GO:0033554|GO:0030431|GO:0044252|GO:0010942|GO:0098542|GO:0001817|GO:0098609|GO:0061061|GO:0005887|GO:0045597|GO:0048635|GO:0010243|GO:0009620|GO:0005737|GO:0001763|GO:0001816|GO:0007267|GO:0002377|GO:0009611|GO:0050920|GO:0032880|GO:0009408|GO:0043235|GO:0005975|GO:0051222|GO:0006928|GO:0009887|GO:0001780|GO:0042592|GO:0031018|GO:0072593|GO:0009615|GO:0002687|GO:0002696|GO:0001775|GO:0009966|GO:0048729|GO:0002263|GO:0050673|GO:0045184|GO:0048771|GO:0009890|GO:0046883|GO:0019725|GO:0006979|GO:0001819|GO:0060548|GO:0042493|GO:0032388|GO:0044236|GO:0010646|GO:0006139|GO:0031226|GO:0009617|GO:0050776|GO:0001525|GO:1900182|GO:0008104|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0045778|GO:0051270|GO:0016477|GO:0007165|GO:0002366|GO:0050778|GO:0030278|GO:0071838|GO:0001503|GO:0051649|GO:0045785|GO:0009409|GO:0046888|GO:0009725|GO:0008219|GO:0090316|GO:0019915|GO:0008285|GO:0031016|GO:0030595|GO:0051607|GO:0051047|GO:0050790|GO:0051048|GO:1903531|GO:0030030|GO:0043086|GO:0010817|GO:0048869|GO:0016021|GO:2000145|GO:0010035|GO:0009967|GO:0044249|GO:0010876|GO:0009266|GO:0048512|GO:0045454|GO:0019538|GO:0023014|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:0002292|GO:0048732|GO:0050878|GO:0050921|GO:0002443|GO:0051090|GO:0007568|GO:0009636|GO:0042107|GO:0000165|GO:0050679|GO:1902533|GO:0051249|GO:0032268|GO:0000902|GO:0042307|GO:0006109|GO:0010574|GO:0031175|GO:0044259|GO:0042113|GO:0042036|GO:0010468|GO:0005126|GO:0034645|GO:0048660|GO:0030168|GO:1901215|GO:0032943|GO:0042089|GO:0006518|GO:0002688|GO:0010712|GO:0007166|GO:0014074|GO:0002009|GO:0070851|GO:0033993|GO:0032675|GO:0001944|GO:0043412|GO:0072594|GO:0030097|GO:0072358|GO:0034097|GO:0030098|GO:0032964|GO:0042542|GO:0032635|GO:0050727|GO:0002237|GO:0010720|GO:0032642|GO:0043069|GO:0002690|GO:0048878|GO:0007596|GO:0002384|GO:0051252|GO:0045187|GO:0045064|GO:0032386|GO:0050709|GO:0034109|GO:0050710|GO:0070997|GO:0051223|GO:0043369|GO:0045667|GO:0015031|GO:1901652|GO:0005125|GO:0045622|GO:0060664|GO:0048659|GO:0061138|GO:0022612|GO:0071864|GO:0010628|GO:0010038|GO:0030334|GO:0043200|GO:0046716|GO:0032755|GO:0001878|GO:0048661|GO:0036211|GO:0045599|GO:0032269|GO:2000377|GO:0070201|GO:0042060|GO:0071219|GO:0046907|GO:0042886|GO:0048872|GO:0006954|GO:0046209|GO:0050714|GO:0001649|GO:0032602|GO:0002828|GO:0051251|GO:1903428|GO:0051091|GO:0048305|GO:0046849|GO:0022407|GO:0007431|GO:0051046|GO:0001781|GO:0043279|GO:0035270|GO:0060326|GO:0050769|GO:0045765|GO:0043434|GO:0007599|GO:0034599|GO:0042035|GO:0019226|GO:0031644|GO:0007159|GO:0009914|GO:0005896|GO:0009306|GO:0005996|GO:0051247|GO:0050729|GO:0051346|GO:0070848|GO:0006508|GO:0045428|GO:0022604|GO:0006259|GO:0050678|GO:0035272|GO:1901214|GO:1904591|GO:0045669|GO:0034613|GO:0046677|GO:0002460|GO:0050663|GO:0002548|GO:0032270|GO:0042110|GO:0012501|GO:0014070|GO:0060429|GO:0000302|GO:0051054|GO:0006796|GO:0043603|GO:1901342|GO:0035556|GO:0044267|GO:0002639|GO:0051174|GO:0002830|GO:0045624|GO:0010467|GO:0017038|GO:0042748|GO:0007399|GO:0046903|GO:0071310|GO:0002637|GO:0045598|GO:0032494|GO:0031328|GO:0006809|GO:0051246|GO:0042742|GO:0042832|GO:0046651|GO:0009059|GO:0030154|GO:0022409|GO:0010996|GO:0030335|GO:0042093|GO:0043068|GO:0007517|GO:0050707|GO:0042745|GO:1903827|GO:1902531|GO:0016070|GO:0008083|GO:0072359|GO:0031667|GO:0032870|GO:0010557|GO:0032496|GO:0016051|GO:0043067|GO:0048545|GO:0097305|GO:1903426|GO:0006606|GO:0051960|GO:0032722|GO:0032682|GO:0045165|GO:0010573|GO:0022410|GO:2000379|GO:0048666|GO:0030182|GO:0035728|GO:0002521|GO:0002790|GO:0051896|GO:0043491|GO:0032966|GO:1904589|GO:0019318|GO:0010466|GO:0042098|GO:0045893|GO:0043043|GO:0045079|GO:0002673|GO:0045444|GO:0019221|GO:0033365|GO:0033157|GO:0031401|GO:0050863|GO:0006260|GO:0070555|GO:0043065|GO:0051169|GO:0043408|GO:0032774|GO:0030162|GO:0051592|GO:0002446|GO:2001141|GO:0045727|GO:0002675|GO:0030217|GO:0050708|GO:0071363|GO:0006111|GO:0016310|GO:0051897|GO:0002526|GO:0015833|GO:0006605|GO:0045619|GO:0010608|GO:0034112|GO:0052547|GO:0070371|GO:0050871|GO:0071383|GO:0071407|GO:0070486|GO:0046631|GO:0016482|GO:0006412|GO:0006886|GO:0010906|GO:0060445|GO:0051024|GO:0045630|GO:0045188|GO:0050830|GO:0006417|GO:0050864|GO:0051023|GO:0043410|GO:0006275|GO:0050755|GO:0002360|GO:0042981|GO:0071345|GO:0045429|GO:0045861|GO:0043066|GO:0050829|GO:0033673|GO:0002295|GO:0032868|GO:0007435|GO:0034612|GO:0042306|GO:0045740|GO:1900180|GO:0034614|GO:0033160|GO:0005138|GO:0022008|GO:0006464|GO:0050870|GO:0045721|GO:0000060|GO:0050767|GO:0071396|GO:0042033|GO:0045621|GO:2000366|GO:0031960|GO:0050671|GO:0007262|GO:0046879|GO:0043549|GO:0071548|GO:0006351|GO:0070301|GO:0006915|GO:0031000|GO:0006355|GO:0072539|GO:0032963|GO:0033500|GO:0071222|GO:0070741|GO:1903039|GO:0032946|GO:0046824|GO:0045666|GO:0042593|GO:0051384|GO:0045582|GO:1903533|GO:0045944|GO:0006366|GO:0030072|GO:0007259|GO:0019319|GO:0006913|GO:0045859|GO:0006469|GO:0071347|GO:0006357|GO:0071549|GO:0043281|GO:0006468|GO:0046632|GO:0048699|GO:0071356|GO:0045580|GO:1903506|GO:0006006|GO:0046425|GO:1904037|GO:0072540|GO:0033158|GO:0035729|GO:0042325|GO:0033028|GO:0071354|GO:0070374|GO:0001932|GO:0070102|GO:0018193|GO:0010951|GO:0042326|GO:0046427|GO:0071384|GO:0001934|GO:0006953|GO:0042129|GO:0035710|GO:0001933|GO:0070372|GO:0043154|GO:0071593|GO:0045664|GO:0042327|GO:0042102|GO:0034504|GO:0046822|GO:0006925|GO:0052548|GO:0050731|GO:0071385|GO:0051170|GO:2000676|GO:2000117|GO:0097050|GO:0050730|GO:0046638|GO:0033138|GO:0007260|GO:0070091|GO:0006094|GO:0018105|GO:0042531|GO:0033135|GO:2000116|GO:0043367|GO:2000516|GO:0018108|GO:0042516|GO:0042517|GO:0043372|GO:0043370|GO:0042503 locomotion|developmental process|growth|macromolecular complex|immune system process|behavior|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|regulation of circadian rhythm|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|rhythmic behavior|regulation of cellular process|leukocyte activation|regulation of locomotion|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|circadian rhythm|positive regulation of behavior|organic substance metabolic process|leukocyte migration|immune response|response to abiotic stimulus|cell surface|negative regulation of transport|cellular metabolic process|cellular localization|regulation of behavior|leukocyte homeostasis|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to other organism|negative regulation of lipid storage|cell adhesion|single-organism behavior|cell periphery|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|anatomical structure development|T cell selection|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cell proliferation|negative regulation of cytokine production|cellular carbohydrate metabolic process|positive regulation of cellular component movement|reactive oxygen species biosynthetic process|regulation of cell proliferation|adaptive immune response|regulation of hemopoiesis|regulation of transmission of nerve impulse|coagulation|single organismal cell-cell adhesion|regulation of lipid storage|T cell activation involved in immune response|regulation of cell shape|chemotaxis|humoral immune response|regulation of cell differentiation|external side of plasma membrane|cellular aromatic compound metabolic process|response to electrical stimulus|positive regulation of transmission of nerve impulse|leukocyte proliferation|tissue development|regulation of leukocyte migration|cell development|positive regulation of cell activation|transport|response to mechanical stimulus|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to protozoan|response to extracellular stimulus|plasma membrane protein complex|multicellular organism development|negative regulation of cell differentiation|animal organ development|neurological system process|T cell aggregation|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|defense response|regulation of cell adhesion|reactive nitrogen species metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|type 2 immune response|positive T cell selection|positive regulation of cell motility|cellular response to stress|sleep|negative regulation of multicellular organismal metabolic process|positive regulation of cell death|defense response to other organism|regulation of cytokine production|cell-cell adhesion|muscle structure development|integral component of plasma membrane|positive regulation of cell differentiation|negative regulation of muscle organ development|response to organonitrogen compound|response to fungus|cytoplasm|morphogenesis of a branching structure|cytokine production|cell-cell signaling|immunoglobulin production|response to wounding|regulation of chemotaxis|regulation of protein localization|response to heat|receptor complex|carbohydrate metabolic process|positive regulation of protein transport|movement of cell or subcellular component|organ morphogenesis|neutrophil homeostasis|homeostatic process|endocrine pancreas development|reactive oxygen species metabolic process|response to virus|positive regulation of leukocyte migration|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|tissue morphogenesis|cell activation involved in immune response|epithelial cell proliferation|establishment of protein localization|tissue remodeling|negative regulation of biosynthetic process|regulation of hormone secretion|cellular homeostasis|response to oxidative stress|positive regulation of cytokine production|negative regulation of cell death|response to drug|positive regulation of intracellular transport|multicellular organism metabolic process|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|response to bacterium|regulation of immune response|angiogenesis|positive regulation of protein localization to nucleus|protein localization|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|positive regulation of ossification|regulation of cellular component movement|cell migration|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|regulation of ossification|cell proliferation in bone marrow|ossification|establishment of localization in cell|positive regulation of cell adhesion|response to cold|negative regulation of hormone secretion|response to hormone|cell death|positive regulation of intracellular protein transport|lipid storage|negative regulation of cell proliferation|pancreas development|leukocyte chemotaxis|defense response to virus|positive regulation of secretion|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|cell projection organization|negative regulation of catalytic activity|regulation of hormone levels|cellular developmental process|integral component of membrane|regulation of cell motility|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|response to temperature stimulus|circadian behavior|cell redox homeostasis|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|T cell differentiation involved in immune response|gland development|regulation of body fluid levels|positive regulation of chemotaxis|leukocyte mediated immunity|regulation of sequence-specific DNA binding transcription factor activity|aging|response to toxic substance|cytokine metabolic process|MAPK cascade|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cell morphogenesis|positive regulation of protein import into nucleus|regulation of carbohydrate metabolic process|regulation of vascular endothelial growth factor production|neuron projection development|multicellular organismal macromolecule metabolic process|B cell activation|negative regulation of cytokine biosynthetic process|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|platelet activation|negative regulation of neuron death|mononuclear cell proliferation|cytokine biosynthetic process|peptide metabolic process|regulation of leukocyte chemotaxis|regulation of collagen metabolic process|cell surface receptor signaling pathway|response to purine-containing compound|morphogenesis of an epithelium|growth factor receptor binding|response to lipid|regulation of interleukin-6 production|vasculature development|macromolecule modification|establishment of protein localization to organelle|hemopoiesis|cardiovascular system development|response to cytokine|lymphocyte differentiation|collagen biosynthetic process|response to hydrogen peroxide|interleukin-6 production|regulation of inflammatory response|response to molecule of bacterial origin|positive regulation of cell development|regulation of chemokine production|negative regulation of programmed cell death|positive regulation of leukocyte chemotaxis|chemical homeostasis|blood coagulation|hepatic immune response|regulation of RNA metabolic process|regulation of circadian sleep/wake cycle, sleep|T-helper 2 cell differentiation|regulation of intracellular transport|negative regulation of protein secretion|homotypic cell-cell adhesion|negative regulation of cytokine secretion|neuron death|regulation of protein transport|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|regulation of osteoblast differentiation|protein transport|response to peptide|cytokine activity|regulation of T-helper cell differentiation|epithelial cell proliferation involved in salivary gland morphogenesis|smooth muscle cell proliferation|morphogenesis of a branching epithelium|gland morphogenesis|positive regulation of cell proliferation in bone marrow|positive regulation of gene expression|response to metal ion|regulation of cell migration|response to amino acid|muscle cell cellular homeostasis|positive regulation of interleukin-6 production|response to yeast|positive regulation of smooth muscle cell proliferation|protein modification process|negative regulation of fat cell differentiation|negative regulation of cellular protein metabolic process|regulation of reactive oxygen species metabolic process|regulation of establishment of protein localization|wound healing|cellular response to molecule of bacterial origin|intracellular transport|amide transport|homeostasis of number of cells|inflammatory response|nitric oxide metabolic process|positive regulation of protein secretion|osteoblast differentiation|chemokine production|regulation of type 2 immune response|positive regulation of lymphocyte activation|positive regulation of reactive oxygen species biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|immunoglobulin secretion|bone remodeling|regulation of cell-cell adhesion|salivary gland development|regulation of secretion|neutrophil apoptotic process|response to alkaloid|endocrine system development|cell chemotaxis|positive regulation of neurogenesis|regulation of angiogenesis|response to peptide hormone|hemostasis|cellular response to oxidative stress|regulation of cytokine biosynthetic process|transmission of nerve impulse|regulation of neurological system process|leukocyte cell-cell adhesion|hormone transport|interleukin-6 receptor complex|protein secretion|monosaccharide metabolic process|positive regulation of protein metabolic process|positive regulation of inflammatory response|negative regulation of hydrolase activity|response to growth factor|proteolysis|regulation of nitric oxide biosynthetic process|regulation of cell morphogenesis|DNA metabolic process|regulation of epithelial cell proliferation|exocrine system development|regulation of neuron death|positive regulation of protein import|positive regulation of osteoblast differentiation|cellular protein localization|response to antibiotic|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|cytokine secretion|monocyte chemotaxis|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|response to organic cyclic compound|epithelium development|response to reactive oxygen species|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|cellular amide metabolic process|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|positive regulation of immunoglobulin production|regulation of phosphorus metabolic process|positive regulation of type 2 immune response|positive regulation of T-helper cell differentiation|gene expression|protein import|circadian sleep/wake cycle, non-REM sleep|nervous system development|secretion|cellular response to organic substance|regulation of immunoglobulin production|regulation of fat cell differentiation|response to peptidoglycan|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|defense response to bacterium|defense response to protozoan|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|response to auditory stimulus|positive regulation of cell migration|T-helper cell differentiation|positive regulation of programmed cell death|muscle organ development|regulation of cytokine secretion|circadian sleep/wake cycle|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|growth factor activity|circulatory system development|response to nutrient levels|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|carbohydrate biosynthetic process|regulation of programmed cell death|response to steroid hormone|response to alcohol|regulation of reactive oxygen species biosynthetic process|protein import into nucleus|regulation of nervous system development|positive regulation of chemokine production|negative regulation of chemokine production|cell fate commitment|vascular endothelial growth factor production|circadian sleep/wake cycle process|positive regulation of reactive oxygen species metabolic process|neuron development|neuron differentiation|response to hepatocyte growth factor|leukocyte differentiation|peptide secretion|regulation of protein kinase B signaling|protein kinase B signaling|negative regulation of collagen biosynthetic process|regulation of protein import|hexose metabolic process|negative regulation of peptidase activity|T cell proliferation|positive regulation of transcription, DNA-templated|peptide biosynthetic process|negative regulation of chemokine biosynthetic process|regulation of acute inflammatory response|fat cell differentiation|cytokine-mediated signaling pathway|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|regulation of T cell activation|DNA replication|response to interleukin-1|positive regulation of apoptotic process|nuclear transport|regulation of MAPK cascade|RNA biosynthetic process|regulation of proteolysis|response to calcium ion|neutrophil mediated immunity|regulation of RNA biosynthetic process|positive regulation of translation|positive regulation of acute inflammatory response|T cell differentiation|regulation of protein secretion|cellular response to growth factor stimulus|regulation of gluconeogenesis|phosphorylation|positive regulation of protein kinase B signaling|acute inflammatory response|peptide transport|protein targeting|regulation of lymphocyte differentiation|posttranscriptional regulation of gene expression|positive regulation of homotypic cell-cell adhesion|regulation of peptidase activity|ERK1 and ERK2 cascade|positive regulation of B cell activation|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|leukocyte aggregation|alpha-beta T cell activation|cytosolic transport|translation|intracellular protein transport|regulation of glucose metabolic process|branching involved in salivary gland morphogenesis|positive regulation of immunoglobulin secretion|positive regulation of T-helper 2 cell differentiation|regulation of circadian sleep/wake cycle, non-REM sleep|defense response to Gram-positive bacterium|regulation of translation|regulation of B cell activation|regulation of immunoglobulin secretion|positive regulation of MAPK cascade|regulation of DNA replication|chemokine metabolic process|T cell lineage commitment|regulation of apoptotic process|cellular response to cytokine stimulus|positive regulation of nitric oxide biosynthetic process|negative regulation of proteolysis|negative regulation of apoptotic process|defense response to Gram-negative bacterium|negative regulation of kinase activity|T-helper cell lineage commitment|response to insulin|salivary gland morphogenesis|response to tumor necrosis factor|regulation of protein import into nucleus|positive regulation of DNA replication|regulation of protein localization to nucleus|cellular response to reactive oxygen species|positive regulation of protein import into nucleus, translocation|interleukin-6 receptor binding|neurogenesis|cellular protein modification process|positive regulation of T cell activation|negative regulation of gluconeogenesis|protein import into nucleus, translocation|regulation of neurogenesis|cellular response to lipid|chemokine biosynthetic process|positive regulation of lymphocyte differentiation|positive regulation of STAT protein import into nucleus|response to corticosteroid|positive regulation of lymphocyte proliferation|STAT protein import into nucleus|hormone secretion|regulation of kinase activity|response to dexamethasone|transcription, DNA-templated|cellular response to hydrogen peroxide|apoptotic process|response to caffeine|regulation of transcription, DNA-templated|T-helper 17 cell differentiation|collagen metabolic process|carbohydrate homeostasis|cellular response to lipopolysaccharide|response to interleukin-6|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|positive regulation of nucleocytoplasmic transport|positive regulation of neuron differentiation|glucose homeostasis|response to glucocorticoid|positive regulation of T cell differentiation|regulation of protein targeting|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|JAK-STAT cascade|hexose biosynthetic process|nucleocytoplasmic transport|regulation of protein kinase activity|negative regulation of protein kinase activity|cellular response to interleukin-1|regulation of transcription from RNA polymerase II promoter|cellular response to dexamethasone stimulus|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|alpha-beta T cell differentiation|generation of neurons|cellular response to tumor necrosis factor|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|glucose metabolic process|regulation of JAK-STAT cascade|positive regulation of epithelial cell apoptotic process|T-helper 17 cell lineage commitment|regulation of protein import into nucleus, translocation|cellular response to hepatocyte growth factor stimulus|regulation of phosphorylation|myeloid cell apoptotic process|cellular response to interleukin-6|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|interleukin-6-mediated signaling pathway|peptidyl-amino acid modification|negative regulation of endopeptidase activity|negative regulation of phosphorylation|positive regulation of JAK-STAT cascade|cellular response to corticosteroid stimulus|positive regulation of protein phosphorylation|acute-phase response|regulation of T cell proliferation|CD4-positive, alpha-beta T cell activation|negative regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|lymphocyte aggregation|regulation of neuron differentiation|positive regulation of phosphorylation|positive regulation of T cell proliferation|protein localization to nucleus|regulation of nucleocytoplasmic transport|inflammatory cell apoptotic process|regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|cellular response to glucocorticoid stimulus|nuclear import|positive regulation of type B pancreatic cell apoptotic process|negative regulation of cysteine-type endopeptidase activity|type B pancreatic cell apoptotic process|regulation of peptidyl-tyrosine phosphorylation|positive regulation of alpha-beta T cell differentiation|positive regulation of peptidyl-serine phosphorylation|tyrosine phosphorylation of STAT protein|glucagon secretion|gluconeogenesis|peptidyl-serine phosphorylation|positive regulation of tyrosine phosphorylation of STAT protein|regulation of peptidyl-serine phosphorylation|regulation of cysteine-type endopeptidase activity|CD4-positive, alpha-beta T cell differentiation|positive regulation of CD4-positive, alpha-beta T cell activation|peptidyl-tyrosine phosphorylation|regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of CD4-positive, alpha-beta T cell differentiation|regulation of CD4-positive, alpha-beta T cell differentiation|tyrosine phosphorylation of Stat3 protein K05405 interleukin 6[-] hsa05200|hsa04151|hsa04060|hsa05166|hsa05168|hsa05202|hsa05152|hsa05164|hsa04630|hsa04932|hsa05161|hsa05162|hsa04068|hsa04668|hsa04931|hsa04620|hsa05142|hsa04066|hsa04933|hsa05146|hsa05323|hsa04640|hsa05132|hsa05410|hsa05133|hsa05321|hsa04623|hsa04621|hsa05134|hsa05144|hsa04672|hsa05332|hsa05020|hsa05143 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Hepatitis B - Homo sapiens (human)|Measles - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Pertussis - Homo sapiens (human)|Inflammatory bowel disease (IBD) - Homo sapiens (human)|Cytosolic DNA-sensing pathway - Homo sapiens (human)|NOD-like receptor signaling pathway - Homo sapiens (human)|Legionellosis - Homo sapiens (human)|Malaria - Homo sapiens (human)|Intestinal immune network for IgA production - Homo sapiens (human)|Graft-versus-host disease - Homo sapiens (human)|Prion diseases - Homo sapiens (human)|African trypanosomiasis - Homo sapiens (human) 7:22725884-22732002 10 16 23 8 3 1 0.144265884046839 0.209789278659007 0.299176386242615 0.103415627341358 0.0355153092808738 0.0135194259387555 0.217743849649487 0.0508167875203291 2.09925488863416 0.000326314887802903 0.00223795190913574 UP ENSG00000163590 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L [Source:HGNC Symbol;Acc:HGNC:16381] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0044255|GO:0016788|GO:0044281|GO:0031982|GO:0043231|GO:0043169|GO:0005737|GO:0007154|GO:0006629|GO:0007165|GO:0005783|GO:0070062|GO:0016021|GO:0044249|GO:0019538|GO:0023014|GO:0000165|GO:0006665|GO:0046872|GO:0007166|GO:0043412|GO:0006643|GO:0036211|GO:0006796|GO:0035556|GO:0044267|GO:0008610|GO:0042578|GO:0016311|GO:0016310|GO:0007167|GO:0016791|GO:0030148|GO:0006464|GO:0006470|GO:0006468|GO:0004721|GO:0007178|GO:0004722 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|cellular lipid metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell communication|lipid metabolic process|signal transduction|endoplasmic reticulum|extracellular exosome|integral component of membrane|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|MAPK cascade|sphingolipid metabolic process|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|membrane lipid metabolic process|protein modification process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|lipid biosynthetic process|phosphoric ester hydrolase activity|dephosphorylation|phosphorylation|enzyme linked receptor protein signaling pathway|phosphatase activity|sphingolipid biosynthetic process|cellular protein modification process|protein dephosphorylation|protein phosphorylation|phosphoprotein phosphatase activity|transmembrane receptor protein serine/threonine kinase signaling pathway|protein serine/threonine phosphatase activity - - - - 3:160755602-161078907 117 148 307 339 428 646 0.478088573748152 0.549622824083085 1.13103583561539 1.24113983445661 1.43494361715384 2.47391547496022 0.719582411148876 1.71666630885689 -1.25437780272844 0.00032649165947377 0.00223864997747587 DOWN ENSG00000234498 RPL13AP20 ribosomal protein L13a pseudogene 20 [Source:HGNC Symbol;Acc:HGNC:35709] - - - - - - 12:12875499-12876107 59 46 44 15 17 30 6.85294887736286 4.85585532945352 4.60782847208811 1.56105210180049 1.62014453118466 3.26577081828104 5.43887755963483 2.14898915042206 1.33965074905879 0.00032768847645465 0.00224530910628348 UP ENSG00000279148 RP11-135F9.4 - - - - - - - 12:100026248-100027540 4 0 2 16 14 9 0.218819993652483 0 0.0986512791905855 0.784245571150278 0.628411800531581 0.461440236001442 0.105823757614356 0.6246992025611 -2.56149813696527 0.000328407097213787 0.00224971672331813 DOWN ENSG00000277481 PKD1L3 polycystic kidney disease 1-like 3 [Source:HGNC Symbol;Acc:HGNC:21716] GO:0032502|GO:0032991|GO:0004871|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0004872|GO:0022857|GO:0051606|GO:0009628|GO:0009986|GO:0038023|GO:0030246|GO:0043227|GO:0071944|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0001822|GO:0006810|GO:0009612|GO:0007275|GO:0048513|GO:0050877|GO:0031982|GO:0009582|GO:0004888|GO:0043235|GO:0022891|GO:0009268|GO:0050906|GO:1902495|GO:0055085|GO:0009593|GO:0070062|GO:0016021|GO:0001655|GO:0050907|GO:0015267|GO:0072001|GO:0006811|GO:0015075|GO:0007600|GO:0010447|GO:0071467|GO:0034702|GO:0050982|GO:0004930|GO:0034220|GO:0071468|GO:0098655|GO:0005216|GO:0034703|GO:0006812|GO:0008527|GO:0050912|GO:0007606|GO:0008324|GO:0033040|GO:0050909|GO:0001581|GO:0022890|GO:0030001|GO:0005261|GO:0005262|GO:0070588|GO:0050915|GO:0046873|GO:0006816|GO:0015085 developmental process|macromolecular complex|signal transducer activity|transporter activity|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|receptor activity|transmembrane transporter activity|detection of stimulus|response to abiotic stimulus|cell surface|signaling receptor activity|carbohydrate binding|membrane-bounded organelle|cell periphery|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|protein complex|anatomical structure development|kidney development|transport|response to mechanical stimulus|multicellular organism development|animal organ development|neurological system process|vesicle|detection of abiotic stimulus|transmembrane signaling receptor activity|receptor complex|substrate-specific transmembrane transporter activity|response to pH|detection of stimulus involved in sensory perception|transmembrane transporter complex|transmembrane transport|detection of chemical stimulus|extracellular exosome|integral component of membrane|urogenital system development|detection of chemical stimulus involved in sensory perception|channel activity|renal system development|ion transport|ion transmembrane transporter activity|sensory perception|response to acidic pH|cellular response to pH|ion channel complex|detection of mechanical stimulus|G-protein coupled receptor activity|ion transmembrane transport|cellular response to acidic pH|cation transmembrane transport|ion channel activity|cation channel complex|cation transport|taste receptor activity|detection of chemical stimulus involved in sensory perception of taste|sensory perception of chemical stimulus|cation transmembrane transporter activity|sour taste receptor activity|sensory perception of taste|detection of chemical stimulus involved in sensory perception of sour taste|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|calcium channel activity|calcium ion transmembrane transport|sensory perception of sour taste|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity K04989 polycystin 1L3[-] hsa04742 Taste transduction - Homo sapiens (human) 16:71929538-71999978 10 6 5 1 0 1 0.13605224648618 0.0741919239227576 0.0613304261986341 0.0121848035200639 0 0.0127497105939062 0.0905248655358572 0.0083115047046567 3.4451325392468 0.000328656406308601 0.00225039960001199 UP ENSG00000261732 LA16c-431H6.6 - - - - - - - 16:1632259-1686715 33 50 91 129 174 129 0.438285198781974 0.603523301530881 1.08968003394979 1.53508100907388 1.89610260955827 1.60569262203937 0.710496178087548 1.67895874689051 -1.24066798872078 0.000329793481913994 0.00225662493904662 DOWN ENSG00000118514 ALDH8A1 aldehyde dehydrogenase 8 family member A1 [Source:HGNC Symbol;Acc:HGNC:15471] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0016491|GO:0071704|GO:0044237|GO:0042445|GO:0043227|GO:0009058|GO:0005622|GO:0006081|GO:0044255|GO:0006082|GO:0044281|GO:0031982|GO:0005737|GO:0016903|GO:0006629|GO:0070062|GO:0010817|GO:0044249|GO:0055114|GO:0005829|GO:0042573|GO:0006720|GO:0016620|GO:0008299|GO:0042574|GO:0008610|GO:0002138|GO:0004029|GO:0001758|GO:0019752|GO:0016101|GO:0032787|GO:0042904|GO:0001523 cell|cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|oxidoreductase activity|organic substance metabolic process|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|cellular aldehyde metabolic process|cellular lipid metabolic process|organic acid metabolic process|small molecule metabolic process|vesicle|cytoplasm|oxidoreductase activity, acting on the aldehyde or oxo group of donors|lipid metabolic process|extracellular exosome|regulation of hormone levels|cellular biosynthetic process|oxidation-reduction process|cytosol|retinoic acid metabolic process|isoprenoid metabolic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|isoprenoid biosynthetic process|retinal metabolic process|lipid biosynthetic process|retinoic acid biosynthetic process|aldehyde dehydrogenase (NAD) activity|retinal dehydrogenase activity|carboxylic acid metabolic process|diterpenoid metabolic process|monocarboxylic acid metabolic process|9-cis-retinoic acid biosynthetic process|retinoid metabolic process - - - - 6:134917390-134950122 3 2 1 11 10 17 0.0307140114788631 0.0186070338868508 0.00922498955424667 0.100891073743728 0.0839941809620538 0.163096773505356 0.0195153449733202 0.115994009403713 -2.5713694275488 0.000331128931665652 0.00226524361272832 DOWN ENSG00000118137 APOA1 apolipoprotein A-I [Source:HGNC Symbol;Acc:HGNC:600] GO:0040011|GO:0032502|GO:0032991|GO:0045499|GO:0005215|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0002683|GO:0033218|GO:0097159|GO:0009892|GO:0048523|GO:0032994|GO:0051606|GO:0044877|GO:0008283|GO:0034358|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0009628|GO:0009986|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0009653|GO:0097006|GO:0016043|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0005615|GO:0030234|GO:0050793|GO:0005622|GO:0002682|GO:0072562|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0042802|GO:0060341|GO:0001818|GO:0044255|GO:0031210|GO:0050817|GO:0016337|GO:0004857|GO:0042277|GO:0006935|GO:0045595|GO:0048468|GO:0009314|GO:0006810|GO:0051130|GO:1901360|GO:0006082|GO:0018158|GO:0034446|GO:0009991|GO:0007275|GO:0005496|GO:0048513|GO:0005102|GO:0034641|GO:0043168|GO:0008047|GO:0044281|GO:0032940|GO:0006952|GO:0030155|GO:0005543|GO:0031982|GO:0002374|GO:0019637|GO:0031325|GO:0051128|GO:0033554|GO:0022607|GO:0060761|GO:0001817|GO:0034364|GO:0098609|GO:0009582|GO:0030141|GO:0045597|GO:0043231|GO:0043178|GO:0043169|GO:0019899|GO:0005737|GO:0032970|GO:0001816|GO:0009611|GO:0032880|GO:0060352|GO:0006928|GO:0042592|GO:0001775|GO:0031589|GO:0009966|GO:0048598|GO:0002367|GO:0050673|GO:0045184|GO:0005319|GO:0032231|GO:0042493|GO:0010646|GO:0043085|GO:0007162|GO:0050776|GO:0008104|GO:0007154|GO:0044092|GO:0060354|GO:0055085|GO:0006629|GO:0016477|GO:0007165|GO:0032233|GO:0005783|GO:0034369|GO:0009968|GO:0070062|GO:0031647|GO:0042180|GO:0045785|GO:0007586|GO:0050777|GO:0009725|GO:0019915|GO:0050892|GO:0050790|GO:0051048|GO:1903531|GO:0010903|GO:0030030|GO:0031983|GO:0043086|GO:0048869|GO:0030029|GO:0009967|GO:0034381|GO:0044249|GO:0010876|GO:0042627|GO:0034377|GO:0019538|GO:0010033|GO:0051224|GO:0031323|GO:0048732|GO:0050878|GO:0005768|GO:0006996|GO:0055114|GO:0007584|GO:0051017|GO:0090207|GO:0016192|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007186|GO:0098742|GO:0044058|GO:0015248|GO:0045940|GO:0010872|GO:0090132|GO:0008654|GO:0034645|GO:0030168|GO:0046486|GO:0007166|GO:0032956|GO:0001959|GO:0033993|GO:0005548|GO:0031102|GO:0043412|GO:0009583|GO:1900026|GO:0007010|GO:0034097|GO:0031410|GO:0051345|GO:0034370|GO:0050727|GO:0016042|GO:0050821|GO:0010720|GO:0005769|GO:0050996|GO:0010873|GO:0048678|GO:0048878|GO:0006720|GO:0007596|GO:0032692|GO:0006066|GO:0044242|GO:0009308|GO:0006631|GO:0071813|GO:0031100|GO:0050709|GO:0050710|GO:0034380|GO:0051223|GO:0015031|GO:0070325|GO:0046889|GO:0000904|GO:0050919|GO:0009790|GO:0070586|GO:0050994|GO:0001935|GO:0002740|GO:0001667|GO:0016023|GO:0006887|GO:0002718|GO:0036211|GO:0032934|GO:0070201|GO:0007369|GO:0042060|GO:0006811|GO:0006954|GO:0046470|GO:0044241|GO:0007602|GO:0022408|GO:0022407|GO:0051046|GO:0006638|GO:0042157|GO:0035270|GO:0034366|GO:0032368|GO:0050728|GO:0007599|GO:0034384|GO:0006869|GO:0009306|GO:0010810|GO:0051346|GO:0031988|GO:0034365|GO:0022604|GO:0055102|GO:0030325|GO:0030036|GO:0010565|GO:0008202|GO:0002739|GO:0050663|GO:0014070|GO:0006796|GO:0034113|GO:0035556|GO:0060205|GO:0033043|GO:0044267|GO:0051174|GO:0060228|GO:0034375|GO:1900024|GO:0005788|GO:0008610|GO:0007399|GO:0019216|GO:0046903|GO:0071310|GO:0046890|GO:0031328|GO:0051246|GO:0001960|GO:0010770|GO:0010470|GO:0009059|GO:0010811|GO:0030154|GO:0034774|GO:0045923|GO:0051496|GO:0050707|GO:0030258|GO:1902531|GO:0031667|GO:0034361|GO:0051180|GO:0005634|GO:0051492|GO:0009416|GO:0006644|GO:0048545|GO:0034190|GO:0045995|GO:0032652|GO:0001540|GO:0010638|GO:0048666|GO:0030182|GO:0019217|GO:0015914|GO:0017127|GO:0071682|GO:0050711|GO:0006820|GO:0015711|GO:0019221|GO:0045055|GO:0032651|GO:0030139|GO:0010803|GO:0006656|GO:0010769|GO:0046474|GO:0034372|GO:0065005|GO:0019218|GO:0030299|GO:0034115|GO:0050708|GO:0046461|GO:0016310|GO:0007229|GO:0043627|GO:0008035|GO:0032611|GO:0061564|GO:0010804|GO:0006694|GO:0051493|GO:0006633|GO:0070653|GO:0009584|GO:0032691|GO:0006576|GO:0016125|GO:0042158|GO:0010631|GO:0015918|GO:0045723|GO:0071345|GO:0060192|GO:0010898|GO:0050801|GO:0019752|GO:0055088|GO:0006639|GO:0051057|GO:0007603|GO:0034612|GO:0050701|GO:0015485|GO:0006897|GO:0031032|GO:0051056|GO:0022008|GO:0030038|GO:0007264|GO:0034191|GO:0006464|GO:0031103|GO:0007015|GO:0051495|GO:0042304|GO:0060193|GO:0006650|GO:0008211|GO:0007265|GO:0046578|GO:0061365|GO:0050706|GO:0006468|GO:0048699|GO:0050713|GO:0030300|GO:0071356|GO:0046579|GO:0032374|GO:0055090|GO:0042325|GO:0046464|GO:0030301|GO:0001932|GO:0055081|GO:0016126|GO:0018193|GO:0006898|GO:0043149|GO:0008203|GO:0016101|GO:0033209|GO:0055091|GO:0032787|GO:0050702|GO:0014012|GO:0002576|GO:0061572|GO:0043542|GO:0033700|GO:0055092|GO:0006641|GO:0043691|GO:0070508|GO:0001523|GO:0018206|GO:0070328|GO:0033344|GO:0035023|GO:0006695|GO:0007266|GO:0051006|GO:0042632|GO:0019433|GO:0035025|GO:0043534|GO:0034435|GO:0032489|GO:0032488 locomotion|developmental process|macromolecular complex|chemorepellent activity|transporter activity|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|negative regulation of immune system process|amide binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|protein-lipid complex|detection of stimulus|macromolecular complex binding|cell proliferation|plasma lipoprotein particle|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|immune response|response to abiotic stimulus|cell surface|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|anatomical structure morphogenesis|regulation of plasma lipoprotein particle levels|cellular component organization|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|extracellular space|enzyme regulator activity|regulation of developmental process|intracellular|regulation of immune system process|blood microparticle|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|identical protein binding|regulation of cellular localization|negative regulation of cytokine production|cellular lipid metabolic process|phosphatidylcholine binding|coagulation|single organismal cell-cell adhesion|enzyme inhibitor activity|peptide binding|chemotaxis|regulation of cell differentiation|cell development|response to radiation|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|organic acid metabolic process|protein oxidation|substrate adhesion-dependent cell spreading|response to extracellular stimulus|multicellular organism development|steroid binding|animal organ development|receptor binding|cellular nitrogen compound metabolic process|anion binding|enzyme activator activity|small molecule metabolic process|secretion by cell|defense response|regulation of cell adhesion|phospholipid binding|vesicle|cytokine secretion involved in immune response|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|negative regulation of response to cytokine stimulus|regulation of cytokine production|high-density lipoprotein particle|cell-cell adhesion|detection of abiotic stimulus|secretory granule|positive regulation of cell differentiation|intracellular membrane-bounded organelle|alcohol binding|cation binding|enzyme binding|cytoplasm|regulation of actin filament-based process|cytokine production|response to wounding|regulation of protein localization|cell adhesion molecule production|movement of cell or subcellular component|homeostatic process|cell activation|cell-substrate adhesion|regulation of signal transduction|embryonic morphogenesis|cytokine production involved in immune response|epithelial cell proliferation|establishment of protein localization|lipid transporter activity|regulation of actin filament bundle assembly|response to drug|regulation of cell communication|positive regulation of catalytic activity|negative regulation of cell adhesion|regulation of immune response|protein localization|cell communication|negative regulation of molecular function|negative regulation of cell adhesion molecule production|transmembrane transport|lipid metabolic process|cell migration|signal transduction|positive regulation of actin filament bundle assembly|endoplasmic reticulum|plasma lipoprotein particle remodeling|negative regulation of signal transduction|extracellular exosome|regulation of protein stability|cellular ketone metabolic process|positive regulation of cell adhesion|digestion|negative regulation of immune response|response to hormone|lipid storage|intestinal absorption|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|negative regulation of very-low-density lipoprotein particle remodeling|cell projection organization|vesicle lumen|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|positive regulation of signal transduction|plasma lipoprotein particle clearance|cellular biosynthetic process|lipid localization|chylomicron|plasma lipoprotein particle assembly|protein metabolic process|response to organic substance|negative regulation of protein transport|regulation of cellular metabolic process|gland development|regulation of body fluid levels|endosome|organelle organization|oxidation-reduction process|response to nutrient|actin filament bundle assembly|regulation of triglyceride metabolic process|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of digestive system process|sterol transporter activity|positive regulation of steroid metabolic process|regulation of cholesterol esterification|epithelium migration|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|platelet activation|glycerolipid metabolic process|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|regulation of cytokine-mediated signaling pathway|response to lipid|phospholipid transporter activity|neuron projection regeneration|macromolecule modification|detection of light stimulus|positive regulation of substrate adhesion-dependent cell spreading|cytoskeleton organization|response to cytokine|cytoplasmic vesicle|positive regulation of hydrolase activity|triglyceride-rich lipoprotein particle remodeling|regulation of inflammatory response|lipid catabolic process|protein stabilization|positive regulation of cell development|early endosome|positive regulation of lipid catabolic process|positive regulation of cholesterol esterification|response to axon injury|chemical homeostasis|isoprenoid metabolic process|blood coagulation|negative regulation of interleukin-1 production|alcohol metabolic process|cellular lipid catabolic process|amine metabolic process|fatty acid metabolic process|lipoprotein particle binding|organ regeneration|negative regulation of protein secretion|negative regulation of cytokine secretion|high-density lipoprotein particle assembly|regulation of protein transport|protein transport|lipoprotein particle receptor binding|positive regulation of lipid biosynthetic process|cell morphogenesis involved in differentiation|negative chemotaxis|embryo development|cell-cell adhesion involved in gastrulation|regulation of lipid catabolic process|endothelial cell proliferation|negative regulation of cytokine secretion involved in immune response|ameboidal-type cell migration|cytoplasmic, membrane-bounded vesicle|exocytosis|regulation of cytokine production involved in immune response|protein modification process|sterol binding|regulation of establishment of protein localization|gastrulation|wound healing|ion transport|inflammatory response|phosphatidylcholine metabolic process|lipid digestion|phototransduction|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|regulation of secretion|neutral lipid metabolic process|lipoprotein metabolic process|endocrine system development|spherical high-density lipoprotein particle|regulation of lipid transport|negative regulation of inflammatory response|hemostasis|high-density lipoprotein particle clearance|lipid transport|protein secretion|regulation of cell-substrate adhesion|negative regulation of hydrolase activity|membrane-bounded vesicle|discoidal high-density lipoprotein particle|regulation of cell morphogenesis|lipase inhibitor activity|adrenal gland development|actin cytoskeleton organization|regulation of cellular ketone metabolic process|steroid metabolic process|regulation of cytokine secretion involved in immune response|cytokine secretion|response to organic cyclic compound|phosphate-containing compound metabolic process|heterotypic cell-cell adhesion|intracellular signal transduction|cytoplasmic membrane-bounded vesicle lumen|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|phosphatidylcholine-sterol O-acyltransferase activator activity|high-density lipoprotein particle remodeling|regulation of substrate adhesion-dependent cell spreading|endoplasmic reticulum lumen|lipid biosynthetic process|nervous system development|regulation of lipid metabolic process|secretion|cellular response to organic substance|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|negative regulation of cytokine-mediated signaling pathway|positive regulation of cell morphogenesis involved in differentiation|regulation of gastrulation|macromolecule biosynthetic process|positive regulation of cell-substrate adhesion|cell differentiation|secretory granule lumen|positive regulation of fatty acid metabolic process|positive regulation of stress fiber assembly|regulation of cytokine secretion|lipid modification|regulation of intracellular signal transduction|response to nutrient levels|very-low-density lipoprotein particle|vitamin transport|nucleus|regulation of stress fiber assembly|response to light stimulus|phospholipid metabolic process|response to steroid hormone|apolipoprotein receptor binding|regulation of embryonic development|regulation of interleukin-1 production|beta-amyloid binding|positive regulation of organelle organization|neuron development|neuron differentiation|regulation of fatty acid metabolic process|phospholipid transport|cholesterol transporter activity|endocytic vesicle lumen|negative regulation of interleukin-1 secretion|anion transport|organic anion transport|cytokine-mediated signaling pathway|regulated exocytosis|regulation of interleukin-1 beta production|endocytic vesicle|regulation of tumor necrosis factor-mediated signaling pathway|phosphatidylcholine biosynthetic process|regulation of cell morphogenesis involved in differentiation|glycerophospholipid biosynthetic process|very-low-density lipoprotein particle remodeling|protein-lipid complex assembly|regulation of steroid metabolic process|intestinal cholesterol absorption|negative regulation of heterotypic cell-cell adhesion|regulation of protein secretion|neutral lipid catabolic process|phosphorylation|integrin-mediated signaling pathway|response to estrogen|high-density lipoprotein particle binding|interleukin-1 beta production|axon development|negative regulation of tumor necrosis factor-mediated signaling pathway|steroid biosynthetic process|regulation of cytoskeleton organization|fatty acid biosynthetic process|high-density lipoprotein particle receptor binding|detection of visible light|negative regulation of interleukin-1 beta production|cellular biogenic amine metabolic process|sterol metabolic process|lipoprotein biosynthetic process|epithelial cell migration|sterol transport|positive regulation of fatty acid biosynthetic process|cellular response to cytokine stimulus|negative regulation of lipase activity|positive regulation of triglyceride catabolic process|ion homeostasis|carboxylic acid metabolic process|lipid homeostasis|acylglycerol metabolic process|positive regulation of small GTPase mediated signal transduction|phototransduction, visible light|response to tumor necrosis factor|interleukin-1 secretion|cholesterol binding|endocytosis|actomyosin structure organization|regulation of small GTPase mediated signal transduction|neurogenesis|contractile actin filament bundle assembly|small GTPase mediated signal transduction|apolipoprotein A-I receptor binding|cellular protein modification process|axon regeneration|actin filament organization|positive regulation of cytoskeleton organization|regulation of fatty acid biosynthetic process|positive regulation of lipase activity|glycerophospholipid metabolic process|glucocorticoid metabolic process|Ras protein signal transduction|regulation of Ras protein signal transduction|positive regulation of triglyceride lipase activity|regulation of interleukin-1 beta secretion|protein phosphorylation|generation of neurons|negative regulation of interleukin-1 beta secretion|regulation of intestinal cholesterol absorption|cellular response to tumor necrosis factor|positive regulation of Ras protein signal transduction|regulation of cholesterol transport|acylglycerol homeostasis|regulation of phosphorylation|acylglycerol catabolic process|cholesterol transport|regulation of protein phosphorylation|anion homeostasis|sterol biosynthetic process|peptidyl-amino acid modification|receptor-mediated endocytosis|stress fiber assembly|cholesterol metabolic process|diterpenoid metabolic process|tumor necrosis factor-mediated signaling pathway|phospholipid homeostasis|monocarboxylic acid metabolic process|interleukin-1 beta secretion|peripheral nervous system axon regeneration|platelet degranulation|actin filament bundle organization|endothelial cell migration|phospholipid efflux|sterol homeostasis|triglyceride metabolic process|reverse cholesterol transport|cholesterol import|retinoid metabolic process|peptidyl-methionine modification|triglyceride homeostasis|cholesterol efflux|regulation of Rho protein signal transduction|cholesterol biosynthetic process|Rho protein signal transduction|positive regulation of lipoprotein lipase activity|cholesterol homeostasis|triglyceride catabolic process|positive regulation of Rho protein signal transduction|blood vessel endothelial cell migration|cholesterol esterification|regulation of Cdc42 protein signal transduction|Cdc42 protein signal transduction K08757 apolipoprotein A-I[-] hsa03320|hsa04975|hsa05143|hsa04977 PPAR signaling pathway - Homo sapiens (human)|Fat digestion and absorption - Homo sapiens (human)|African trypanosomiasis - Homo sapiens (human)|Vitamin digestion and absorption - Homo sapiens (human) 11:116835751-116837950 8 9 6 1 2 0 0.302118795293818 0.308924796246394 0.204307694597053 0.0338221001072141 0.0619692118631989 0 0.271783762045755 0.031930437323471 3.08945504612897 0.000334355532634964 0.00228522208591671 UP ENSG00000279522 CTC-487M23.6 - - - - - - - 5:112894933-112896531 11 22 14 3 6 4 0.48661808812024 0.884503218098517 0.558406959320819 0.118893370052834 0.217764228554919 0.165817999694104 0.643176088513192 0.167491866100619 1.94112273640795 0.000335077670611826 0.002289109560285 UP ENSG00000228487 RP13-225O21.2 - - - - - - - 9:127213783-127221907 0 1 2 7 6 14 0 0.0669279154390628 0.132732678453098 0.461637782665786 0.362336109739141 0.965807980009217 0.0665535312973869 0.596593957471381 -3.16416224362304 0.000337071670109847 0.00230052551298587 DOWN ENSG00000073282 TP63 tumor protein p63 [Source:HGNC Symbol;Acc:HGNC:15979] GO:0032502|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0009628|GO:0019953|GO:0044237|GO:0003006|GO:0023051|GO:0000989|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0032504|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0048609|GO:0019222|GO:0042802|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0048565|GO:0035844|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0007164|GO:2000381|GO:0048468|GO:0009314|GO:0022402|GO:0035295|GO:1901360|GO:0010941|GO:0036342|GO:0060742|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0051302|GO:0002039|GO:0034641|GO:0031069|GO:0031325|GO:0046483|GO:0033554|GO:0022607|GO:0010942|GO:0045786|GO:0045597|GO:0043231|GO:0060740|GO:0048608|GO:0043169|GO:0001942|GO:0005737|GO:0000981|GO:0007389|GO:0035112|GO:0001763|GO:0007267|GO:0060512|GO:0009887|GO:0005667|GO:0042592|GO:0043005|GO:0009966|GO:0048729|GO:0048598|GO:0007548|GO:0050673|GO:0009890|GO:0036477|GO:0045787|GO:0003682|GO:0048871|GO:0019904|GO:0060548|GO:0010646|GO:0006139|GO:0000790|GO:0007154|GO:0045778|GO:0007276|GO:0007165|GO:0005783|GO:0030278|GO:0001503|GO:0090344|GO:0008219|GO:0048645|GO:0050790|GO:0051301|GO:0048869|GO:0048806|GO:2000773|GO:0060157|GO:0009967|GO:0044249|GO:0030850|GO:0019538|GO:0031324|GO:0031323|GO:0048732|GO:0050878|GO:0006996|GO:0072089|GO:0007568|GO:0050679|GO:0051276|GO:0000982|GO:2001235|GO:0005829|GO:0003677|GO:0045682|GO:0048485|GO:0030540|GO:0010468|GO:0000075|GO:0034645|GO:2000772|GO:0060529|GO:0090068|GO:0048232|GO:0055123|GO:0046872|GO:0007166|GO:0002009|GO:1903047|GO:0061458|GO:0001655|GO:0010629|GO:0050891|GO:0007498|GO:0045605|GO:0043069|GO:0048483|GO:0002064|GO:0022405|GO:0048878|GO:0051252|GO:0006325|GO:0070997|GO:0010463|GO:0044770|GO:0045667|GO:0061138|GO:0022612|GO:0009790|GO:0001736|GO:0010628|GO:0050699|GO:0000278|GO:0030856|GO:0060537|GO:0005791|GO:0072001|GO:0001649|GO:0010259|GO:0048807|GO:0007499|GO:0003002|GO:0007569|GO:0031981|GO:0016331|GO:0007346|GO:0043589|GO:0045747|GO:0030425|GO:0010564|GO:0071478|GO:0045930|GO:0006508|GO:0008593|GO:0005654|GO:0050678|GO:0005694|GO:0000228|GO:0006461|GO:0043588|GO:1901214|GO:0045669|GO:0012501|GO:0060429|GO:0010212|GO:0035556|GO:0042476|GO:0035108|GO:0010467|GO:0007399|GO:0010482|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0001501|GO:0001228|GO:0060173|GO:0043068|GO:0048546|GO:0016070|GO:0010481|GO:0043616|GO:0010557|GO:0030857|GO:0005634|GO:0009416|GO:0090398|GO:0043067|GO:0060513|GO:0006974|GO:2000648|GO:0097190|GO:0072091|GO:0010948|GO:0042633|GO:0060197|GO:0007283|GO:0010837|GO:0000975|GO:0060571|GO:0045893|GO:0048863|GO:0010332|GO:0097193|GO:0043065|GO:0009411|GO:0051259|GO:0030855|GO:0045892|GO:0043523|GO:0007093|GO:0072331|GO:0042770|GO:0032774|GO:0044772|GO:0043565|GO:0030162|GO:0030216|GO:2001141|GO:0001077|GO:0061436|GO:0044774|GO:1902679|GO:0052547|GO:0000077|GO:0008544|GO:0045604|GO:0030104|GO:0003690|GO:1901990|GO:0003684|GO:1901989|GO:0002053|GO:0045617|GO:0008630|GO:0071482|GO:0048730|GO:0042981|GO:0043066|GO:0010838|GO:0042475|GO:0048745|GO:0016568|GO:1901987|GO:0051402|GO:0009954|GO:0010165|GO:0007219|GO:0060601|GO:0033561|GO:0030326|GO:0001302|GO:0006351|GO:0006915|GO:0006355|GO:0044773|GO:0098773|GO:1901991|GO:0010464|GO:0001738|GO:0045616|GO:0045944|GO:2000045|GO:0006366|GO:0072332|GO:0044346|GO:1903507|GO:0006352|GO:0006357|GO:2000269|GO:0043281|GO:0044819|GO:0030859|GO:0042771|GO:1903506|GO:1902808|GO:0044212|GO:0044783|GO:1902806|GO:2000134|GO:0000082|GO:2000271|GO:0006338|GO:0000122|GO:0051260|GO:0051262|GO:0031571|GO:0042772|GO:0034644|GO:1902807|GO:0030330|GO:0052548|GO:0009913|GO:0006367|GO:0002067|GO:0051289|GO:2000116|GO:0006978 developmental process|macromolecular complex|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|response to abiotic stimulus|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|multicellular organismal reproductive process|regulation of metabolic process|identical protein binding|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|digestive tract development|cloaca development|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|establishment of tissue polarity|negative regulation of mesoderm development|cell development|response to radiation|cell cycle process|tube development|organic cyclic compound metabolic process|regulation of cell death|post-anal tail morphogenesis|epithelial cell differentiation involved in prostate gland development|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|regulation of cell division|p53 binding|cellular nitrogen compound metabolic process|hair follicle morphogenesis|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cellular component assembly|positive regulation of cell death|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|prostate gland epithelium morphogenesis|reproductive structure development|cation binding|hair follicle development|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|genitalia morphogenesis|morphogenesis of a branching structure|cell-cell signaling|prostate gland morphogenesis|organ morphogenesis|transcription factor complex|homeostatic process|neuron projection|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|sex differentiation|epithelial cell proliferation|negative regulation of biosynthetic process|somatodendritic compartment|positive regulation of cell cycle|chromatin binding|multicellular organismal homeostasis|protein domain specific binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|nuclear chromatin|cell communication|positive regulation of ossification|gamete generation|signal transduction|endoplasmic reticulum|regulation of ossification|ossification|negative regulation of cell aging|cell death|organ formation|regulation of catalytic activity|cell division|cellular developmental process|genitalia development|negative regulation of cellular senescence|urinary bladder development|positive regulation of signal transduction|cellular biosynthetic process|prostate gland development|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|regulation of body fluid levels|organelle organization|stem cell proliferation|aging|positive regulation of epithelial cell proliferation|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of apoptotic signaling pathway|cytosol|DNA binding|regulation of epidermis development|sympathetic nervous system development|female genitalia development|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|regulation of cellular senescence|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|positive regulation of cell cycle process|male gamete generation|digestive system development|metal ion binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|mitotic cell cycle process|reproductive system development|urogenital system development|negative regulation of gene expression|multicellular organismal water homeostasis|mesoderm development|negative regulation of epidermal cell differentiation|negative regulation of programmed cell death|autonomic nervous system development|epithelial cell development|hair cycle process|chemical homeostasis|regulation of RNA metabolic process|chromatin organization|neuron death|mesenchymal cell proliferation|cell cycle phase transition|regulation of osteoblast differentiation|morphogenesis of a branching epithelium|gland morphogenesis|embryo development|establishment of planar polarity|positive regulation of gene expression|WW domain binding|mitotic cell cycle|regulation of epithelial cell differentiation|muscle tissue development|rough endoplasmic reticulum|renal system development|osteoblast differentiation|multicellular organism aging|female genitalia morphogenesis|ectoderm and mesoderm interaction|regionalization|cell aging|nuclear lumen|morphogenesis of embryonic epithelium|regulation of mitotic cell cycle|skin morphogenesis|positive regulation of Notch signaling pathway|dendrite|regulation of cell cycle process|cellular response to radiation|negative regulation of mitotic cell cycle|proteolysis|regulation of Notch signaling pathway|nucleoplasm|regulation of epithelial cell proliferation|chromosome|nuclear chromosome|protein complex assembly|skin development|regulation of neuron death|positive regulation of osteoblast differentiation|programmed cell death|epithelium development|response to ionizing radiation|intracellular signal transduction|odontogenesis|limb morphogenesis|gene expression|nervous system development|regulation of epidermal cell division|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|limb development|positive regulation of programmed cell death|digestive tract morphogenesis|RNA metabolic process|epidermal cell division|keratinocyte proliferation|positive regulation of macromolecule biosynthetic process|negative regulation of epithelial cell differentiation|nucleus|response to light stimulus|cellular senescence|regulation of programmed cell death|prostatic bud formation|cellular response to DNA damage stimulus|positive regulation of stem cell proliferation|apoptotic signaling pathway|regulation of stem cell proliferation|negative regulation of cell cycle process|hair cycle|cloacal septation|spermatogenesis|regulation of keratinocyte proliferation|regulatory region DNA binding|morphogenesis of an epithelial fold|positive regulation of transcription, DNA-templated|stem cell differentiation|response to gamma radiation|intrinsic apoptotic signaling pathway|positive regulation of apoptotic process|response to UV|protein oligomerization|epithelial cell differentiation|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of proteolysis|keratinocyte differentiation|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|establishment of skin barrier|mitotic DNA integrity checkpoint|negative regulation of RNA biosynthetic process|regulation of peptidase activity|DNA damage checkpoint|epidermis development|regulation of epidermal cell differentiation|water homeostasis|double-stranded DNA binding|regulation of mitotic cell cycle phase transition|damaged DNA binding|positive regulation of cell cycle phase transition|positive regulation of mesenchymal cell proliferation|negative regulation of keratinocyte differentiation|intrinsic apoptotic signaling pathway in response to DNA damage|cellular response to light stimulus|epidermis morphogenesis|regulation of apoptotic process|negative regulation of apoptotic process|positive regulation of keratinocyte proliferation|odontogenesis of dentin-containing tooth|smooth muscle tissue development|chromatin modification|regulation of cell cycle phase transition|neuron apoptotic process|proximal/distal pattern formation|response to X-ray|Notch signaling pathway|lateral sprouting from an epithelium|regulation of water loss via skin|embryonic limb morphogenesis|replicative cell aging|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|mitotic DNA damage checkpoint|skin epidermis development|negative regulation of mitotic cell cycle phase transition|regulation of mesenchymal cell proliferation|morphogenesis of a polarized epithelium|regulation of keratinocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|intrinsic apoptotic signaling pathway by p53 class mediator|fibroblast apoptotic process|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of fibroblast apoptotic process|regulation of cysteine-type endopeptidase activity involved in apoptotic process|mitotic G1/S transition checkpoint|polarized epithelial cell differentiation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of nucleic acid-templated transcription|positive regulation of cell cycle G1/S phase transition|transcription regulatory region DNA binding|G1 DNA damage checkpoint|regulation of cell cycle G1/S phase transition|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast apoptotic process|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|protein homooligomerization|protein tetramerization|mitotic G1 DNA damage checkpoint|DNA damage response, signal transduction resulting in transcription|cellular response to UV|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator|regulation of endopeptidase activity|epidermal cell differentiation|transcription initiation from RNA polymerase II promoter|glandular epithelial cell differentiation|protein homotetramerization|regulation of cysteine-type endopeptidase activity|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator K10149 tumor protein p63[-] hsa05206 MicroRNAs in cancer - Homo sapiens (human) 3:189631416-189897279 16 28 16 65 54 49 0.0909371097637424 0.144628351134015 0.0819901038042276 0.330997519196058 0.251814036520132 0.261001496385232 0.105851854900662 0.281271017367141 -1.40991435190652 0.000337766242709061 0.00230273427947849 DOWN ENSG00000175087 PDIK1L PDLIM1 interacting kinase 1 like [Source:HGNC Symbol;Acc:HGNC:18981] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0031981|GO:0005654|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005634|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|nuclear lumen|nucleoplasm|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|nucleus|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 1:26111165-26125543 133 221 178 98 45 99 0.853023353728696 1.28819695204753 1.0293069418805 0.563163586982833 0.236806685616659 0.595079789046959 1.05684241588558 0.465016687215484 1.18440588110486 0.000338639813569997 0.00230816278409102 UP ENSG00000232709 MARK2P9 MAP/microtubule affinity-regulating kinase 2 pseudogene 9 [Source:HGNC Symbol;Acc:HGNC:39800] - - - - - - 10:92418667-92420875 25 23 7 4 6 3 1.0239944789389 0.856188982325691 0.25849043995375 0.146799890230075 0.201624204666656 0.115146054506748 0.712891300406114 0.154523383134493 2.20585694610155 0.000340236826937316 0.00231798955531416 UP ENSG00000136535 TBR1 T-box, brain 1 [Source:HGNC Symbol;Acc:HGNC:11590] GO:0040011|GO:0032502|GO:0007610|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0007631|GO:0097159|GO:0003700|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0050795|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0009605|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0006935|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0030902|GO:0030900|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0043231|GO:0007389|GO:0060322|GO:0050920|GO:0021764|GO:0006928|GO:0009887|GO:0006139|GO:0051270|GO:0007611|GO:0048645|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0001661|GO:0000902|GO:0031175|GO:0003677|GO:0031344|GO:0010468|GO:0034645|GO:0007417|GO:0007612|GO:0051252|GO:0021761|GO:0000904|GO:0010628|GO:0003002|GO:0022604|GO:0010092|GO:0021872|GO:0010467|GO:0032990|GO:0007399|GO:0050890|GO:0097485|GO:0031328|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:1902667|GO:0010557|GO:0005634|GO:0051960|GO:0045165|GO:0048666|GO:0030182|GO:0007411|GO:0021953|GO:0000975|GO:0045893|GO:0010975|GO:0010769|GO:0032774|GO:0008306|GO:0043565|GO:2001141|GO:0003690|GO:0048663|GO:0061564|GO:0021879|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0021877|GO:0006357|GO:0007409|GO:0048699|GO:1903506|GO:0044212|GO:0050770|GO:0045664|GO:0001047|GO:0000976|GO:0001012|GO:0021902|GO:0001046|GO:0000977|GO:0000979 locomotion|developmental process|behavior|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|feeding behavior|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of behavior|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|response to external stimulus|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|hindbrain development|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|intracellular membrane-bounded organelle|pattern specification process|head development|regulation of chemotaxis|amygdala development|movement of cell or subcellular component|organ morphogenesis|nucleobase-containing compound metabolic process|regulation of cellular component movement|learning or memory|organ formation|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|conditioned taste aversion|cell morphogenesis|neuron projection development|DNA binding|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|central nervous system development|learning|regulation of RNA metabolic process|limbic system development|cell morphogenesis involved in differentiation|positive regulation of gene expression|regionalization|regulation of cell morphogenesis|specification of organ identity|forebrain generation of neurons|gene expression|cell part morphogenesis|nervous system development|cognition|neuron projection guidance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|regulation of axon guidance|positive regulation of macromolecule biosynthetic process|nucleus|regulation of nervous system development|cell fate commitment|neuron development|neuron differentiation|axon guidance|central nervous system neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|RNA biosynthetic process|associative learning|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|neuron fate commitment|axon development|forebrain neuron differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|forebrain neuron fate commitment|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of axonogenesis|regulation of neuron differentiation|core promoter binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|commitment of neuronal cell to specific neuron type in forebrain|core promoter sequence-specific DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding - - - - 2:161416094-161425870 12 6 4 1 0 1 0.0626240513704816 0.0284562015842432 0.018820524381177 0.00467346318707577 0 0.00489013245132557 0.0366335924453006 0.00318786521280045 3.52250464811553 0.00034394646773128 0.00234112582025755 UP ENSG00000274569 RP11-121C6.4 - - - - - - - 12:56413647-56414045 7 8 1 0 0 0 1.24102273461555 1.28896846273824 0.159761097292843 0 0 0 0.896584098215544 0 Inf 0.000344722458627372 0.00234587286981116 UP ENSG00000233175 CTD-2020K17.3 - - - - - - - 17:45238028-45241734 29 23 33 67 62 86 0.861921309630308 0.621276627090953 0.884303504922133 1.78418354165034 1.51191211504565 2.3954954915915 0.789167147214465 1.89719704942916 -1.26546672634097 0.000351226722597546 0.0023868706069718 DOWN ENSG00000165072 MAMDC2 MAM domain containing 2 [Source:HGNC Symbol;Acc:HGNC:23673] GO:0031012|GO:0005623|GO:0016020|GO:0005576|GO:0043229|GO:0005578|GO:0043227|GO:0005622|GO:0012505|GO:0043231|GO:0005737|GO:0005783 extracellular matrix|cell|membrane|extracellular region|intracellular organelle|proteinaceous extracellular matrix|membrane-bounded organelle|intracellular|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum - - - - 9:70043581-70226970 3 7 11 22 18 57 0.0517517238036928 0.109739463353171 0.171061984342107 0.339993815932289 0.254736192569344 0.921429188925322 0.110851057166324 0.505386399142318 -2.18876431029433 0.000354470501349222 0.00240672329935858 DOWN ENSG00000163734 CXCL3 chemokine (C-X-C motif) ligand 3 [Source:HGNC Symbol;Acc:HGNC:4604] GO:0040011|GO:0002376|GO:0007610|GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0040012|GO:0006950|GO:0048520|GO:0050900|GO:0006955|GO:0050795|GO:0048870|GO:0040017|GO:0051707|GO:0009607|GO:0009605|GO:0005615|GO:0002684|GO:0002682|GO:0005515|GO:0051272|GO:0042127|GO:0006935|GO:0002685|GO:0005102|GO:0006952|GO:2000147|GO:0050920|GO:0006928|GO:0002687|GO:0009617|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0030595|GO:2000145|GO:0010033|GO:0050921|GO:0007186|GO:0005126|GO:0002688|GO:0007166|GO:0033993|GO:0034097|GO:0002237|GO:0002690|GO:0005125|GO:0030334|GO:0006954|GO:0060326|GO:1902622|GO:0001664|GO:0071310|GO:0030335|GO:0032496|GO:0071621|GO:0090023|GO:0019221|GO:1990266|GO:0042379|GO:0071622|GO:0030593|GO:0071624|GO:0008009|GO:0071345|GO:0090022|GO:0045236|GO:0070098 locomotion|immune system process|behavior|signaling|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|response to stress|positive regulation of behavior|leukocyte migration|immune response|regulation of behavior|cell motility|positive regulation of locomotion|response to other organism|response to biotic stimulus|response to external stimulus|extracellular space|positive regulation of immune system process|regulation of immune system process|protein binding|positive regulation of cellular component movement|regulation of cell proliferation|chemotaxis|regulation of leukocyte migration|receptor binding|defense response|positive regulation of cell motility|regulation of chemotaxis|movement of cell or subcellular component|positive regulation of leukocyte migration|response to bacterium|cell communication|regulation of cellular component movement|cell migration|signal transduction|leukocyte chemotaxis|regulation of cell motility|response to organic substance|positive regulation of chemotaxis|G-protein coupled receptor signaling pathway|cytokine receptor binding|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|response to lipid|response to cytokine|response to molecule of bacterial origin|positive regulation of leukocyte chemotaxis|cytokine activity|regulation of cell migration|inflammatory response|cell chemotaxis|regulation of neutrophil migration|G-protein coupled receptor binding|cellular response to organic substance|positive regulation of cell migration|response to lipopolysaccharide|granulocyte chemotaxis|positive regulation of neutrophil chemotaxis|cytokine-mediated signaling pathway|neutrophil migration|chemokine receptor binding|regulation of granulocyte chemotaxis|neutrophil chemotaxis|positive regulation of granulocyte chemotaxis|chemokine activity|cellular response to cytokine stimulus|regulation of neutrophil chemotaxis|CXCR chemokine receptor binding|chemokine-mediated signaling pathway K05505 C-X-C motif chemokine 1/2/3[-] hsa04060|hsa04062|hsa04668|hsa05132|hsa05134 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|Legionellosis - Homo sapiens (human) 4:74036589-74038807 25 28 28 9 7 15 0.450902209364476 0.458960851150929 0.455308186525813 0.145434883823429 0.103587003835713 0.253551048997087 0.455057082347073 0.167524312218743 1.44167704422575 0.000355688431468228 0.00241389461992555 UP ENSG00000167604 NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta [Source:HGNC Symbol;Acc:HGNC:15671] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0000989|GO:0007155|GO:0043227|GO:0023057|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:1903706|GO:0016337|GO:0045595|GO:0003712|GO:0006725|GO:1901360|GO:0010941|GO:0007275|GO:0045596|GO:0048513|GO:0070489|GO:0034641|GO:0006952|GO:0030155|GO:0046483|GO:0010942|GO:0098609|GO:0043231|GO:0001775|GO:0009966|GO:0009890|GO:0010646|GO:0006139|GO:0007162|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0008134|GO:0008219|GO:0002695|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0051090|GO:0051249|GO:0010468|GO:0034645|GO:0030097|GO:0030098|GO:0010629|GO:0051252|GO:0034109|GO:0006954|GO:0051250|GO:0022408|GO:0022407|GO:0007159|GO:0043433|GO:0051059|GO:0042110|GO:0012501|GO:0035556|GO:0010467|GO:1902532|GO:0009059|GO:0030154|GO:0043068|GO:1902531|GO:0016070|GO:0005634|GO:0043067|GO:0002521|GO:1903038|GO:0043124|GO:0050863|GO:0043122|GO:0043065|GO:0045892|GO:0045620|GO:0032774|GO:0050868|GO:2001141|GO:0030217|GO:0045619|GO:1902679|GO:0070486|GO:0033085|GO:0033081|GO:0007249|GO:0042981|GO:0032088|GO:0033077|GO:0034111|GO:0006351|GO:0006915|GO:0006355|GO:2000108|GO:0006366|GO:1903507|GO:0006357|GO:0045580|GO:1903506|GO:0045581|GO:0071593|GO:0070230|GO:0070228|GO:0070231|GO:0070234|GO:0070232|GO:0070242|GO:0070243|GO:0070245 developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|cell adhesion|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|defense response|regulation of cell adhesion|heterocycle metabolic process|positive regulation of cell death|cell-cell adhesion|intracellular membrane-bounded organelle|cell activation|regulation of signal transduction|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|negative regulation of cell adhesion|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|transcription factor binding|cell death|negative regulation of leukocyte activation|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|regulation of lymphocyte activation|regulation of gene expression|cellular macromolecule biosynthetic process|hemopoiesis|lymphocyte differentiation|negative regulation of gene expression|regulation of RNA metabolic process|homotypic cell-cell adhesion|inflammatory response|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|negative regulation of sequence-specific DNA binding transcription factor activity|NF-kappaB binding|T cell activation|programmed cell death|intracellular signal transduction|gene expression|negative regulation of intracellular signal transduction|macromolecule biosynthetic process|cell differentiation|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|nucleus|regulation of programmed cell death|leukocyte differentiation|negative regulation of leukocyte cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB signaling|regulation of T cell activation|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|negative regulation of lymphocyte differentiation|RNA biosynthetic process|negative regulation of T cell activation|regulation of RNA biosynthetic process|T cell differentiation|regulation of lymphocyte differentiation|negative regulation of RNA biosynthetic process|leukocyte aggregation|negative regulation of T cell differentiation in thymus|regulation of T cell differentiation in thymus|I-kappaB kinase/NF-kappaB signaling|regulation of apoptotic process|negative regulation of NF-kappaB transcription factor activity|T cell differentiation in thymus|negative regulation of homotypic cell-cell adhesion|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of leukocyte apoptotic process|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|negative regulation of T cell differentiation|lymphocyte aggregation|positive regulation of lymphocyte apoptotic process|regulation of lymphocyte apoptotic process|T cell apoptotic process|positive regulation of T cell apoptotic process|regulation of T cell apoptotic process|thymocyte apoptotic process|regulation of thymocyte apoptotic process|positive regulation of thymocyte apoptotic process - - - - 19:35887653-35902303 152 141 118 82 81 54 1.67477128593649 1.41192212115369 1.1722133785905 0.809507407963288 0.732256571202474 0.557609556214827 1.41963559522689 0.699791178460196 1.02052427012416 0.000355880341020342 0.00241464811382302 UP ENSG00000262601 CTC-786C10.1 - - - - - - - 16:85171276-85185363 0 0 0 5 5 4 0 0 0 0.407814934270464 0.373487638640792 0.341239358443851 0 0.374180643785036 -Inf 0.000356340137612761 0.00241704953922601 DOWN ENSG00000107902 LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase [Source:HGNC Symbol;Acc:HGNC:30042] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0042802|GO:0016788|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0046983|GO:0019538|GO:0005829|GO:0046872|GO:0043412|GO:0016818|GO:0036211|GO:0031981|GO:0005654|GO:0006796|GO:0044267|GO:0005634|GO:0042803|GO:0042578|GO:0016311|GO:0000287|GO:0016791|GO:0006464|GO:0016462|GO:0006470|GO:0008969|GO:0004427 cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|identical protein binding|hydrolase activity, acting on ester bonds|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|protein dimerization activity|protein metabolic process|cytosol|metal ion binding|macromolecule modification|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|nuclear lumen|nucleoplasm|phosphate-containing compound metabolic process|cellular protein metabolic process|nucleus|protein homodimerization activity|phosphoric ester hydrolase activity|dephosphorylation|magnesium ion binding|phosphatase activity|cellular protein modification process|pyrophosphatase activity|protein dephosphorylation|phosphohistidine phosphatase activity|inorganic diphosphatase activity K11725 phospholysine phosphohistidine inorganic pyrophosphate phosphatase [EC:3.6.1.1 3.1.3.-][-] hsa00190 Oxidative phosphorylation - Homo sapiens (human) 10:124461834-124617888 38 31 83 108 121 206 0.505454666026338 0.374753063014108 0.995376352922692 1.28711463119405 1.32053934327983 2.5679872038021 0.625194693987713 1.72521372609199 -1.46439766017214 0.000356653975699512 0.0024182484193807 DOWN ENSG00000205707 LYRM5 LYR motif containing 5 [Source:HGNC Symbol;Acc:HGNC:27052] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0005739 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|mitochondrion - - - - 12:25195216-25209645 59 93 147 201 257 224 0.542358137272772 0.776965499416677 1.21834178353201 1.6555080709026 1.9383753111692 1.92980382067827 0.845888473407153 1.84122906758336 -1.12212975561917 0.00035838926060476 0.00242835973356662 DOWN ENSG00000154898 CCDC144CP coiled-coil domain containing 144C, pseudogene [Source:HGNC Symbol;Acc:HGNC:29073] - - - - - - 17:20321164-20403557 6 9 20 28 37 52 0.0478198735424215 0.0651961851683938 0.143725187598228 0.199954901946966 0.241961631440914 0.38842612508662 0.0855804154363478 0.276780886158167 -1.69339172984128 0.000358800099394354 0.00243004041908327 DOWN ENSG00000196208 GREB1 growth regulation by estrogen in breast cancer 1 [Source:HGNC Symbol;Acc:HGNC:24885] GO:0016020|GO:0005576|GO:1903561|GO:0043227|GO:0031224|GO:0031982|GO:0070062|GO:0016021 membrane|extracellular region|extracellular vesicle|membrane-bounded organelle|intrinsic component of membrane|vesicle|extracellular exosome|integral component of membrane - - - - 2:11482341-11642788 32 39 56 10 21 22 0.137421475002372 0.152211947895919 0.216822739403972 0.0384779338312498 0.0739925137889146 0.0885440716707749 0.168818720767421 0.0670048397636464 1.33313768689891 0.000362146663430855 0.00245048197870915 UP ENSG00000174130 TLR6 toll-like receptor 6 [Source:HGNC Symbol;Acc:HGNC:16711] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0033218|GO:0004872|GO:0051606|GO:0050794|GO:0043229|GO:0006950|GO:0044089|GO:0071704|GO:0006955|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0008289|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:0009595|GO:0002757|GO:0002250|GO:0042277|GO:0045087|GO:0006810|GO:0051130|GO:0005102|GO:0032940|GO:0006952|GO:0031982|GO:0031325|GO:0051128|GO:0033554|GO:0022607|GO:0098542|GO:0001817|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0002218|GO:0001816|GO:0032880|GO:0012506|GO:0071723|GO:0030666|GO:0009966|GO:0045184|GO:0001819|GO:0010646|GO:0031226|GO:0043085|GO:0009617|GO:0050776|GO:0008104|GO:0007154|GO:0009593|GO:0007165|GO:0050778|GO:0050790|GO:0042226|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0031334|GO:0043254|GO:0023014|GO:0010033|GO:0098857|GO:0031323|GO:0005794|GO:0042107|GO:0000165|GO:0016045|GO:1902533|GO:0032268|GO:0035325|GO:0042089|GO:0032675|GO:0043412|GO:0002758|GO:0031410|GO:0032635|GO:0002237|GO:0051223|GO:0015031|GO:0032755|GO:0016023|GO:0051347|GO:0036211|GO:0070201|GO:0071219|GO:0006954|GO:0045408|GO:1900227|GO:0051046|GO:0031098|GO:0042035|GO:0009306|GO:0051247|GO:0031988|GO:0002764|GO:0006461|GO:0032490|GO:0045410|GO:0042108|GO:0002460|GO:0050663|GO:0032270|GO:0006796|GO:0035556|GO:0030659|GO:0044267|GO:1900225|GO:0051174|GO:0046903|GO:0031328|GO:0051246|GO:0042742|GO:0009059|GO:0045121|GO:0050707|GO:1902531|GO:0010557|GO:0030670|GO:0045089|GO:0045088|GO:0070304|GO:0031401|GO:0043122|GO:0034622|GO:0030139|GO:0043408|GO:0038061|GO:0043623|GO:0050708|GO:0016310|GO:0035663|GO:0042494|GO:0002221|GO:0032611|GO:0043123|GO:0007249|GO:1901222|GO:0043410|GO:0032872|GO:0042088|GO:0050701|GO:0006464|GO:0051403|GO:0043549|GO:1901224|GO:0033674|GO:0045859|GO:0045860|GO:0002224|GO:0043406|GO:0046328|GO:0006468|GO:0043405|GO:0045335|GO:0042325|GO:0044546|GO:0007254|GO:0001932|GO:0007250|GO:0032874|GO:0050702|GO:0001934|GO:0071221|GO:0042327|GO:0071726|GO:0046330|GO:0034134|GO:0038124|GO:0043507|GO:0071902|GO:0042496|GO:0034150|GO:0002755|GO:0071900|GO:0043506|GO:0034142|GO:0038123|GO:0032147 signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|amide binding|receptor activity|detection of stimulus|regulation of cellular process|intracellular organelle|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|immune response|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|lipid binding|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|detection of biotic stimulus|immune response-activating signal transduction|adaptive immune response|peptide binding|innate immune response|transport|positive regulation of cellular component organization|receptor binding|secretion by cell|defense response|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|defense response to other organism|regulation of cytokine production|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|activation of innate immune response|cytokine production|regulation of protein localization|vesicle membrane|lipopeptide binding|endocytic vesicle membrane|regulation of signal transduction|establishment of protein localization|positive regulation of cytokine production|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|response to bacterium|regulation of immune response|protein localization|cell communication|detection of chemical stimulus|signal transduction|positive regulation of immune response|regulation of catalytic activity|interleukin-6 biosynthetic process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|regulation of cellular metabolic process|Golgi apparatus|cytokine metabolic process|MAPK cascade|detection of bacterium|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|Toll-like receptor binding|cytokine biosynthetic process|regulation of interleukin-6 production|macromolecule modification|innate immune response-activating signal transduction|cytoplasmic vesicle|interleukin-6 production|response to molecule of bacterial origin|regulation of protein transport|protein transport|positive regulation of interleukin-6 production|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|protein modification process|regulation of establishment of protein localization|cellular response to molecule of bacterial origin|inflammatory response|regulation of interleukin-6 biosynthetic process|positive regulation of NLRP3 inflammasome complex assembly|regulation of secretion|stress-activated protein kinase signaling cascade|regulation of cytokine biosynthetic process|protein secretion|positive regulation of protein metabolic process|membrane-bounded vesicle|immune response-regulating signaling pathway|protein complex assembly|detection of molecule of bacterial origin|positive regulation of interleukin-6 biosynthetic process|positive regulation of cytokine biosynthetic process|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|cytokine secretion|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic vesicle membrane|cellular protein metabolic process|regulation of NLRP3 inflammasome complex assembly|regulation of phosphorus metabolic process|secretion|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|defense response to bacterium|macromolecule biosynthetic process|membrane raft|regulation of cytokine secretion|regulation of intracellular signal transduction|positive regulation of macromolecule biosynthetic process|phagocytic vesicle membrane|positive regulation of innate immune response|regulation of innate immune response|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|cellular macromolecular complex assembly|endocytic vesicle|regulation of MAPK cascade|NIK/NF-kappaB signaling|cellular protein complex assembly|regulation of protein secretion|phosphorylation|Toll-like receptor 2 binding|detection of bacterial lipoprotein|pattern recognition receptor signaling pathway|interleukin-1 beta production|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|regulation of NIK/NF-kappaB signaling|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|T-helper 1 type immune response|interleukin-1 secretion|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|positive regulation of NIK/NF-kappaB signaling|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|toll-like receptor signaling pathway|positive regulation of MAP kinase activity|regulation of JNK cascade|protein phosphorylation|regulation of MAP kinase activity|phagocytic vesicle|regulation of phosphorylation|NLRP3 inflammasome complex assembly|JNK cascade|regulation of protein phosphorylation|activation of NF-kappaB-inducing kinase activity|positive regulation of stress-activated MAPK cascade|interleukin-1 beta secretion|positive regulation of protein phosphorylation|cellular response to bacterial lipopeptide|positive regulation of phosphorylation|cellular response to diacyl bacterial lipopeptide|positive regulation of JNK cascade|toll-like receptor 2 signaling pathway|toll-like receptor TLR6:TLR2 signaling pathway|positive regulation of JUN kinase activity|positive regulation of protein serine/threonine kinase activity|detection of diacyl bacterial lipopeptide|toll-like receptor 6 signaling pathway|MyD88-dependent toll-like receptor signaling pathway|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|toll-like receptor 4 signaling pathway|toll-like receptor TLR1:TLR2 signaling pathway|activation of protein kinase activity K10169 toll-like receptor 6[-] hsa05152|hsa04145|hsa04620|hsa05142 Tuberculosis - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human) 4:38823715-38856817 61 151 208 368 319 339 0.382974993623787 0.861579217058433 1.17737650426446 2.07006162605579 1.6432190337495 1.99464705361343 0.80731023831556 1.90264257113957 -1.23680947036885 0.000363149461267757 0.00245671063147238 DOWN ENSG00000231057 RP11-122M14.1 - - - - - - - 1:211675762-211690103 1 0 1 4 7 13 0.0231188152311708 0 0.0208247885723112 0.0828237211458147 0.132724021249156 0.281560184061136 0.014647867934494 0.165702642152036 -3.49983401267068 0.000363329800393019 0.00245737377909678 DOWN ENSG00000100321 SYNGR1 synaptogyrin 1 [Source:HGNC Symbol;Acc:HGNC:11498] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0042995|GO:0030672|GO:0008021|GO:0031594|GO:0050794|GO:0043229|GO:0051641|GO:0023051|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0050804|GO:0006810|GO:0043195|GO:0031982|GO:0050803|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0012506|GO:0043005|GO:0045184|GO:0030658|GO:0010646|GO:0008104|GO:0007154|GO:0051649|GO:0044306|GO:0016021|GO:0048167|GO:0030424|GO:0031410|GO:0015031|GO:0016023|GO:0070382|GO:0046907|GO:0043679|GO:0031988|GO:0034613|GO:0030659|GO:0048168|GO:0006605|GO:0006886|GO:0048172|GO:0048169|GO:0042470|GO:0007268 synapse|signaling|cell|membrane|cellular process|cell junction|binding|cell projection|synaptic vesicle membrane|synaptic vesicle|neuromuscular junction|regulation of cellular process|intracellular organelle|cellular localization|regulation of signaling|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|endomembrane system|organelle membrane|modulation of synaptic transmission|transport|terminal bouton|vesicle|regulation of synapse structure or activity|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|vesicle membrane|neuron projection|establishment of protein localization|transport vesicle membrane|regulation of cell communication|protein localization|cell communication|establishment of localization in cell|neuron projection terminus|integral component of membrane|regulation of synaptic plasticity|axon|cytoplasmic vesicle|protein transport|cytoplasmic, membrane-bounded vesicle|exocytic vesicle|intracellular transport|axon terminus|membrane-bounded vesicle|cellular protein localization|cytoplasmic vesicle membrane|regulation of neuronal synaptic plasticity|protein targeting|intracellular protein transport|regulation of short-term neuronal synaptic plasticity|regulation of long-term neuronal synaptic plasticity|melanosome|synaptic transmission - - - - 22:39349925-39385588 279 303 514 621 653 1040 2.07764591908076 2.05064564213243 3.45100021030763 4.1434040473205 3.98977759681892 7.25822178683296 2.52643059050694 5.13046781032413 -1.02198983593128 0.000363477884995803 0.0024577080811986 DOWN ENSG00000171786 NHLH1 nescient helix-loop-helix 1 [Source:HGNC Symbol;Acc:HGNC:7817] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0000981|GO:0046983|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0007417|GO:0051252|GO:0010628|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|protein dimerization activity|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|central nervous system development|regulation of RNA metabolic process|positive regulation of gene expression|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 1:160367067-160372848 17 8 8 0 1 4 0.469178189853006 0.200662667433693 0.199073123672926 0 0.0226544001499619 0.10345024639519 0.289637993653208 0.0420348821817173 2.7845919277624 0.000366068143283573 0.00247197429305311 UP ENSG00000260118 RP6-201G10.2 - - - - - - - X:68013470-68014901 0 0 1 4 5 11 0 0 0.0445144398183272 0.177041487728589 0.202653558117246 0.509227455241132 0.0148381466061091 0.296307500362322 -4.3197123402836 0.000366691280801189 0.00247562222909062 DOWN ENSG00000135773 CAPN9 calpain 9 [Source:HGNC Symbol;Acc:HGNC:1486] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0043167|GO:0016787|GO:0005622|GO:0043169|GO:0008233|GO:0007586|GO:0019538|GO:0046872|GO:0006508|GO:0005509|GO:0004175|GO:0008234|GO:0004197|GO:0004198 cell|metabolic process|binding|catalytic activity|organic substance metabolic process|ion binding|hydrolase activity|intracellular|cation binding|peptidase activity|digestion|protein metabolic process|metal ion binding|proteolysis|calcium ion binding|endopeptidase activity|cysteine-type peptidase activity|cysteine-type endopeptidase activity|calcium-dependent cysteine-type endopeptidase activity - - - - 1:230747384-230802003 1 2 8 12 18 22 0.0212130375967068 0.0385415480090345 0.152944968817059 0.227988678441851 0.313151416584796 0.437199624868406 0.0708998514742668 0.326113239965018 -2.20151850433851 0.000366952220171629 0.00247682378046661 DOWN ENSG00000254593 OR7E126P olfactory receptor family 7 subfamily E member 126 pseudogene [Source:HGNC Symbol;Acc:HGNC:15304] - - - - - - 11:71903194-71904081 1 0 4 11 12 8 0.0796922223227634 0 0.287288522507719 0.785087071586891 0.78431095075176 0.597248288031697 0.122326914943494 0.722215436790116 -2.5616873897506 0.000367285469231088 0.00247851274828772 DOWN ENSG00000259112 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough [Source:HGNC Symbol;Acc:HGNC:42956] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0070469|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0006725|GO:0019866|GO:1901360|GO:0034641|GO:0015980|GO:0044281|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0031966|GO:0006139|GO:0016651|GO:0055086|GO:0006091|GO:0016021|GO:0022900|GO:0055114|GO:0005740|GO:0019693|GO:0009116|GO:0022904|GO:0005743|GO:0005739|GO:0016655|GO:0006796|GO:0006119|GO:0045333|GO:0003954|GO:0009259|GO:0009117|GO:0042773|GO:0016310|GO:0006163|GO:0006120|GO:0042278|GO:0042775|GO:0008137|GO:0046034 cell|membrane|cellular process|metabolic process|catalytic activity|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|respiratory chain|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|cellular aromatic compound metabolic process|organelle inner membrane|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|nucleobase-containing compound metabolic process|oxidoreductase activity, acting on NAD(P)H|nucleobase-containing small molecule metabolic process|generation of precursor metabolites and energy|integral component of membrane|electron transport chain|oxidation-reduction process|mitochondrial envelope|ribose phosphate metabolic process|nucleoside metabolic process|respiratory electron transport chain|mitochondrial inner membrane|mitochondrion|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|phosphate-containing compound metabolic process|oxidative phosphorylation|cellular respiration|NADH dehydrogenase activity|ribonucleotide metabolic process|nucleotide metabolic process|ATP synthesis coupled electron transport|phosphorylation|purine nucleotide metabolic process|mitochondrial electron transport, NADH to ubiquinone|purine nucleoside metabolic process|mitochondrial ATP synthesis coupled electron transport|NADH dehydrogenase (ubiquinone) activity|ATP metabolic process K03968 NADH dehydrogenase (ubiquinone) 1 subunit C2[-] hsa01100|hsa05016|hsa05010|hsa04932|hsa05012|hsa00190 Metabolic pathways - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Parkinson,s disease - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human) 11:78016971-78079865 444 254 189 107 81 180 19.5318157275255 10.1548350299028 7.49611409190736 4.21736742238132 2.92356168353227 7.4209670520819 12.3942549497786 4.8539653859985 1.35243582429028 0.00036860998939909 0.00248688872847919 UP ENSG00000231856 RP11-327P2.5 - - - - - - - 13:51803838-51813832 8 9 11 3 0 2 0.190271857291634 0.19455821902135 0.235886078610282 0.0639241757614262 0 0.0445768294402946 0.206905384974422 0.0361670017339069 2.51622528586925 0.000371212347266334 0.00250331452796231 UP ENSG00000232453 RP4-794H19.1 - - - - - - - 1:58882868-58903747 3 5 2 14 15 17 0.0589866090380611 0.0893460075189598 0.0354519466351937 0.24661810352854 0.241967672504638 0.313229212040581 0.0612615210640715 0.267271662691253 -2.12525379165035 0.000373772220003291 0.00251779094947364 DOWN ENSG00000186792 HYAL3 hyaluronoglucosaminidase 3 [Source:HGNC Symbol;Acc:HGNC:5322] GO:0032502|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0009628|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0016787|GO:0005622|GO:0005515|GO:0048856|GO:0009888|GO:0009314|GO:0007275|GO:0048513|GO:0016798|GO:0006952|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0009615|GO:0010033|GO:0009636|GO:0030214|GO:0051216|GO:0034097|GO:0031410|GO:0005773|GO:0006954|GO:0071478|GO:0046677|GO:0004553|GO:0071310|GO:0001501|GO:0061448|GO:0009416|GO:0070555|GO:0009411|GO:0000323|GO:0071482|GO:0071345|GO:0034612|GO:0030203|GO:0033906|GO:0010224|GO:0071347|GO:0005764|GO:0006027|GO:0071356|GO:0004415|GO:0034644|GO:0030212|GO:0071493 developmental process|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|response to abiotic stimulus|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|hydrolase activity|intracellular|protein binding|anatomical structure development|tissue development|response to radiation|multicellular organism development|animal organ development|hydrolase activity, acting on glycosyl bonds|defense response|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|response to virus|response to organic substance|response to toxic substance|hyaluronan catabolic process|cartilage development|response to cytokine|cytoplasmic vesicle|vacuole|inflammatory response|cellular response to radiation|response to antibiotic|hydrolase activity, hydrolyzing O-glycosyl compounds|cellular response to organic substance|skeletal system development|connective tissue development|response to light stimulus|response to interleukin-1|response to UV|lytic vacuole|cellular response to light stimulus|cellular response to cytokine stimulus|response to tumor necrosis factor|glycosaminoglycan metabolic process|hyaluronoglucuronidase activity|response to UV-B|cellular response to interleukin-1|lysosome|glycosaminoglycan catabolic process|cellular response to tumor necrosis factor|hyalurononglucosaminidase activity|cellular response to UV|hyaluronan metabolic process|cellular response to UV-B K01197 hyaluronoglucosaminidase[3.2.1.35] hsa01100|hsa00531 Metabolic pathways - Homo sapiens (human)|Glycosaminoglycan degradation - Homo sapiens (human) 3:50292831-50299468 119 79 137 38 52 71 1.83751548265675 1.10865035776127 1.90730397387288 0.525738546354 0.658810121089237 1.02747261642026 1.6178232714303 0.737340427954499 1.13365125215269 0.000374045683547038 0.00251900740731182 UP ENSG00000269821 KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:6295] - - - - - - 11:2608328-2699994 100 100 202 268 275 367 0.0771672204780455 0.0701313472449949 0.140539482709889 0.185295596394813 0.174113597534269 0.265416134201946 0.0959460168109765 0.208275109377009 -1.11819561607847 0.000375877596326087 0.00253077351391949 DOWN ENSG00000242220 TCP10L t-complex 10-like [Source:HGNC Symbol;Acc:HGNC:11657] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0042802|GO:0003712|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0001076|GO:0009890|GO:0006139|GO:0043621|GO:0008134|GO:0044249|GO:0031324|GO:0031323|GO:0010468|GO:0034645|GO:0003714|GO:0001104|GO:0010629|GO:0051252|GO:0070491|GO:0010467|GO:0009059|GO:0001191|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0001106|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|identical protein binding|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|transcription factor activity, RNA polymerase II transcription factor binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|protein self-association|transcription factor binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|RNA polymerase II transcription cofactor activity|negative regulation of gene expression|regulation of RNA metabolic process|repressing transcription factor binding|gene expression|macromolecule biosynthetic process|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|RNA polymerase II transcription corepressor activity|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 21:32574841-32587373 13 14 14 4 4 4 0.256647906447277 0.251192360900634 0.249202547572981 0.0707573012635609 0.0647883526764006 0.0740002739354933 0.252347604973631 0.0698486426251516 1.85310840911035 0.000377613224814001 0.00254074041325157 UP ENSG00000121236 TRIM6 tripartite motif containing 6 [Source:HGNC Symbol;Acc:HGNC:16277] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0060090|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0016874|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0019222|GO:0016032|GO:0060341|GO:0045087|GO:0045595|GO:0006725|GO:0060760|GO:0006810|GO:1901360|GO:0050688|GO:0045596|GO:0034641|GO:0032940|GO:0006952|GO:0002374|GO:0031325|GO:0046483|GO:0022607|GO:0098542|GO:0001817|GO:0051098|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0001816|GO:0032880|GO:0051222|GO:0042592|GO:0009615|GO:0009966|GO:0002367|GO:0045184|GO:0009890|GO:0019725|GO:0030674|GO:0001819|GO:0010646|GO:0006139|GO:0009617|GO:0050776|GO:0008104|GO:0007154|GO:0007165|GO:0050778|GO:0008134|GO:0048525|GO:0019787|GO:0051607|GO:0051047|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0050792|GO:0010033|GO:0031324|GO:0031323|GO:0032268|GO:0005829|GO:0034340|GO:0010468|GO:0034645|GO:0051101|GO:0046872|GO:0007166|GO:2000736|GO:0001959|GO:0033993|GO:0043412|GO:0034097|GO:0010629|GO:0004842|GO:0002237|GO:0051252|GO:0051223|GO:0015031|GO:0010628|GO:0002718|GO:0010994|GO:0036211|GO:0001961|GO:0070201|GO:0050714|GO:0050715|GO:0002720|GO:0051046|GO:0098586|GO:0009306|GO:0051099|GO:0010992|GO:0051247|GO:0006461|GO:0002739|GO:0050663|GO:0019900|GO:0032270|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0019079|GO:0046903|GO:0019058|GO:0071310|GO:2000737|GO:0051246|GO:0009059|GO:0030154|GO:0050707|GO:0016070|GO:0032496|GO:0005634|GO:0045089|GO:0002741|GO:0045088|GO:0050691|GO:0048863|GO:0019221|GO:0035456|GO:0031401|GO:2000677|GO:0061630|GO:0034622|GO:0051259|GO:0045892|GO:0060338|GO:0032774|GO:2001141|GO:0043623|GO:0050708|GO:0071357|GO:0016310|GO:0045069|GO:1902679|GO:0043388|GO:0002230|GO:0045071|GO:0071345|GO:0046914|GO:0019901|GO:0060340|GO:0006464|GO:0006351|GO:0006355|GO:0051258|GO:1903507|GO:0035458|GO:0006468|GO:1903506|GO:0042325|GO:0070206|GO:2000679|GO:0001932|GO:0018193|GO:1990782|GO:0001934|GO:0008270|GO:0042327|GO:0060337|GO:0032446|GO:0033138|GO:0018105|GO:0033135|GO:0018107|GO:0010800|GO:0016567|GO:0000209 developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|binding, bridging|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|ligase activity|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|protein binding|transferase activity|regulation of metabolic process|viral process|regulation of cellular localization|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|positive regulation of response to cytokine stimulus|transport|organic cyclic compound metabolic process|regulation of defense response to virus|negative regulation of cell differentiation|cellular nitrogen compound metabolic process|secretion by cell|defense response|cytokine secretion involved in immune response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|defense response to other organism|regulation of cytokine production|regulation of binding|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|cytokine production|regulation of protein localization|positive regulation of protein transport|homeostatic process|response to virus|regulation of signal transduction|cytokine production involved in immune response|establishment of protein localization|negative regulation of biosynthetic process|cellular homeostasis|protein binding, bridging|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|protein localization|cell communication|signal transduction|positive regulation of immune response|transcription factor binding|negative regulation of viral process|ubiquitin-like protein transferase activity|defense response to virus|positive regulation of secretion|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|regulation of viral process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|cytosol|response to type I interferon|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of DNA binding|metal ion binding|cell surface receptor signaling pathway|regulation of stem cell differentiation|regulation of cytokine-mediated signaling pathway|response to lipid|macromolecule modification|response to cytokine|negative regulation of gene expression|ubiquitin-protein transferase activity|response to molecule of bacterial origin|regulation of RNA metabolic process|regulation of protein transport|protein transport|positive regulation of gene expression|regulation of cytokine production involved in immune response|free ubiquitin chain polymerization|protein modification process|positive regulation of cytokine-mediated signaling pathway|regulation of establishment of protein localization|positive regulation of protein secretion|positive regulation of cytokine secretion|positive regulation of cytokine production involved in immune response|regulation of secretion|cellular response to virus|protein secretion|positive regulation of binding|ubiquitin homeostasis|positive regulation of protein metabolic process|protein complex assembly|regulation of cytokine secretion involved in immune response|cytokine secretion|kinase binding|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|viral genome replication|secretion|viral life cycle|cellular response to organic substance|negative regulation of stem cell differentiation|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|regulation of cytokine secretion|RNA metabolic process|response to lipopolysaccharide|nucleus|positive regulation of innate immune response|positive regulation of cytokine secretion involved in immune response|regulation of innate immune response|regulation of defense response to virus by host|stem cell differentiation|cytokine-mediated signaling pathway|response to interferon-beta|positive regulation of protein modification process|regulation of transcription regulatory region DNA binding|ubiquitin protein ligase activity|cellular macromolecular complex assembly|protein oligomerization|negative regulation of transcription, DNA-templated|regulation of type I interferon-mediated signaling pathway|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular protein complex assembly|regulation of protein secretion|cellular response to type I interferon|phosphorylation|regulation of viral genome replication|negative regulation of RNA biosynthetic process|positive regulation of DNA binding|positive regulation of defense response to virus by host|negative regulation of viral genome replication|cellular response to cytokine stimulus|transition metal ion binding|protein kinase binding|positive regulation of type I interferon-mediated signaling pathway|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|protein polymerization|negative regulation of nucleic acid-templated transcription|cellular response to interferon-beta|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|protein trimerization|positive regulation of transcription regulatory region DNA binding|regulation of protein phosphorylation|peptidyl-amino acid modification|protein tyrosine kinase binding|positive regulation of protein phosphorylation|zinc ion binding|positive regulation of phosphorylation|type I interferon signaling pathway|protein modification by small protein conjugation|positive regulation of peptidyl-serine phosphorylation|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|protein ubiquitination|protein polyubiquitination - - - - 11:5596109-5612958 97 117 170 246 242 342 0.453020849085042 0.496609320474647 0.715832684935055 1.02939236733032 0.927324472146061 1.49693289245977 0.555154284831581 1.15121657731205 -1.05219859526288 0.000378212716543274 0.00254362749260709 DOWN ENSG00000085514 PILRA paired immunoglobin-like type 2 receptor alpha [Source:HGNC Symbol;Acc:HGNC:20396] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0016032|GO:0005102|GO:0031982|GO:0005887|GO:0031226|GO:0007154|GO:0007165|GO:0070062|GO:0016021|GO:0007166|GO:0042287|GO:0007167|GO:0042288|GO:0007169 signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|viral process|receptor binding|vesicle|integral component of plasma membrane|intrinsic component of plasma membrane|cell communication|signal transduction|extracellular exosome|integral component of membrane|cell surface receptor signaling pathway|MHC protein binding|enzyme linked receptor protein signaling pathway|MHC class I protein binding|transmembrane receptor protein tyrosine kinase signaling pathway K15411 paired immunoglobulin-like type 2 receptor alpha[-] hsa05168 Herpes simplex infection - Homo sapiens (human) 7:100367530-100400099 17 17 14 5 6 4 0.313642071098919 0.285058570683894 0.232888035460091 0.0826479405133414 0.0908202925037337 0.0691557072276662 0.277196225747635 0.0808746467482471 1.77714820344605 0.000380126324592559 0.00255534593433602 UP ENSG00000276386 CNTNAP3P2 contactin associated protein-like 3 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:49589] - - - - - - 9:67059560-67293468 4 6 5 12 28 22 0.0732800444943435 0.0999025673334413 0.0825840160079509 0.196987886889929 0.420894306183546 0.377751346428646 0.0852555426119119 0.331877846500707 -1.96078679547166 0.00038064600337846 0.00255826334643416 DOWN ENSG00000243838 PSMC1P7 proteasome (prosome, macropain) 26S subunit, ATPase, 1 pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:39782] - - - - - - 3:161328924-161330238 1 1 1 7 8 9 0.0538149759867786 0.0489108188113607 0.0484750401671821 0.33736418946146 0.353103769298874 0.453720323307882 0.0504002783217738 0.381396094022739 -2.91978646295944 0.000380927110383568 0.00255900043955694 DOWN ENSG00000140398 NEIL1 nei-like DNA glycosylase 1 [Source:HGNC Symbol;Acc:HGNC:18448] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0019222|GO:0006281|GO:0006725|GO:0008022|GO:1901360|GO:0003676|GO:0016798|GO:0034641|GO:0016788|GO:0044281|GO:0019637|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0006979|GO:0006139|GO:0055086|GO:0044092|GO:0050790|GO:0043086|GO:0031324|GO:0031323|GO:0003677|GO:0009262|GO:0046872|GO:0043412|GO:0005815|GO:0003906|GO:0006284|GO:0032074|GO:0031981|GO:0004518|GO:0051346|GO:0005654|GO:0006259|GO:0005694|GO:0006796|GO:0019439|GO:0016799|GO:0006289|GO:0046434|GO:0005856|GO:0005634|GO:0006974|GO:0006285|GO:0004536|GO:0009117|GO:0006220|GO:0046386|GO:0006304|GO:0003684|GO:0015630|GO:0019104|GO:0004519|GO:0046914|GO:0009166|GO:0009264|GO:0004520|GO:0009223|GO:0045008|GO:0008270 cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|protein C-terminus binding|organic cyclic compound metabolic process|nucleic acid binding|hydrolase activity, acting on glycosyl bonds|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to oxidative stress|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|deoxyribonucleotide metabolic process|metal ion binding|macromolecule modification|microtubule organizing center|DNA-(apurinic or apyrimidinic site) lyase activity|base-excision repair|negative regulation of nuclease activity|nuclear lumen|nuclease activity|negative regulation of hydrolase activity|nucleoplasm|DNA metabolic process|chromosome|phosphate-containing compound metabolic process|aromatic compound catabolic process|hydrolase activity, hydrolyzing N-glycosyl compounds|nucleotide-excision repair|organophosphate catabolic process|cytoskeleton|nucleus|cellular response to DNA damage stimulus|base-excision repair, AP site formation|deoxyribonuclease activity|nucleotide metabolic process|pyrimidine nucleotide metabolic process|deoxyribose phosphate catabolic process|DNA modification|damaged DNA binding|microtubule cytoskeleton|DNA N-glycosylase activity|endonuclease activity|transition metal ion binding|nucleotide catabolic process|deoxyribonucleotide catabolic process|endodeoxyribonuclease activity|pyrimidine deoxyribonucleotide catabolic process|depyrimidination|zinc ion binding K10567 endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18][-] hsa03410 Base excision repair - Homo sapiens (human) 15:75346955-75357114 46 39 42 98 94 103 0.187543309366766 0.144509233760322 0.154386826254077 0.357990270941422 0.31444152262956 0.393560690196529 0.162146456460388 0.355330827922504 -1.13186536440408 0.000383087367720157 0.00257004275863316 DOWN ENSG00000081138 CDH7 cadherin 7, type 2 [Source:HGNC Symbol;Acc:HGNC:1766] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0043167|GO:0016043|GO:0007155|GO:0071944|GO:0031224|GO:0005886|GO:0016337|GO:0022607|GO:0098609|GO:0043169|GO:0016021|GO:0098742|GO:0045216|GO:0046872|GO:0034329|GO:0034332|GO:0005509|GO:0007156 cell|membrane|cellular process|binding|ion binding|cellular component organization|cell adhesion|cell periphery|intrinsic component of membrane|plasma membrane|single organismal cell-cell adhesion|cellular component assembly|cell-cell adhesion|cation binding|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|cell-cell junction organization|metal ion binding|cell junction assembly|adherens junction organization|calcium ion binding|homophilic cell adhesion via plasma membrane adhesion molecules - - - - 18:65750252-65890341 9 15 13 40 42 28 0.0408151812416934 0.0618245900656438 0.0531530517874347 0.162531733944181 0.156277046689448 0.11900323251874 0.0519309410315906 0.145937337717456 -1.49068276694184 0.00038356319347377 0.00257265683620893 DOWN ENSG00000230590 FTX FTX transcript, XIST regulator (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:37190] - - - - - - X:73963955-74293574 9 10 9 28 24 40 0.0862766224431406 0.0871219705638562 0.0777841297999123 0.240493258541717 0.188770327759199 0.359368803206496 0.0837275742689697 0.262877463169137 -1.65061572961264 0.000384257160452688 0.00257673254001674 DOWN ENSG00000255346 NOX5 NADPH oxidase, EF-hand calcium binding domain 5 [Source:HGNC Symbol;Acc:HGNC:14874] GO:0032502|GO:0000003|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0044702|GO:0043167|GO:0019953|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0048037|GO:0009893|GO:0032504|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007049|GO:0006810|GO:0022402|GO:0001568|GO:0007275|GO:0043168|GO:0032940|GO:0031325|GO:0051128|GO:0043231|GO:0043169|GO:0005737|GO:0001816|GO:0043012|GO:0072593|GO:0050673|GO:0045184|GO:0022891|GO:0016651|GO:0001525|GO:0008104|GO:0061024|GO:0005783|GO:0009566|GO:0008219|GO:0050662|GO:0000166|GO:0051301|GO:0016021|GO:0031323|GO:0055114|GO:0061025|GO:0046872|GO:0020037|GO:0001944|GO:0072358|GO:0050660|GO:0015031|GO:0001935|GO:2000377|GO:0050661|GO:0015267|GO:0006811|GO:0007338|GO:0015075|GO:0009306|GO:0043269|GO:0050663|GO:0050664|GO:0012501|GO:0007342|GO:0046903|GO:0072359|GO:0000910|GO:0006801|GO:2000379|GO:0042554|GO:0005216|GO:0016175|GO:0015992|GO:0006812|GO:0045026|GO:0005509|GO:0010155|GO:0006915|GO:0008324|GO:0005261|GO:0015672|GO:0015252 developmental process|reproduction|transporter activity|cell|membrane|cellular process|reproductive process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|single organism reproductive process|ion binding|sexual reproduction|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cofactor binding|positive regulation of metabolic process|multicellular organism reproduction|intrinsic component of membrane|intracellular|protein binding|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|cell cycle|transport|cell cycle process|blood vessel development|multicellular organism development|anion binding|secretion by cell|positive regulation of cellular metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cation binding|cytoplasm|cytokine production|regulation of fusion of sperm to egg plasma membrane|reactive oxygen species metabolic process|epithelial cell proliferation|establishment of protein localization|substrate-specific transmembrane transporter activity|oxidoreductase activity, acting on NAD(P)H|angiogenesis|protein localization|membrane organization|endoplasmic reticulum|fertilization|cell death|coenzyme binding|nucleotide binding|cell division|integral component of membrane|regulation of cellular metabolic process|oxidation-reduction process|membrane fusion|metal ion binding|heme binding|vasculature development|cardiovascular system development|flavin adenine dinucleotide binding|protein transport|endothelial cell proliferation|regulation of reactive oxygen species metabolic process|NADP binding|channel activity|ion transport|single fertilization|ion transmembrane transporter activity|protein secretion|regulation of ion transport|cytokine secretion|oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor|programmed cell death|fusion of sperm to egg plasma membrane|secretion|circulatory system development|cytokinesis|superoxide metabolic process|positive regulation of reactive oxygen species metabolic process|superoxide anion generation|ion channel activity|superoxide-generating NADPH oxidase activity|proton transport|cation transport|plasma membrane fusion|calcium ion binding|regulation of proton transport|apoptotic process|cation transmembrane transporter activity|cation channel activity|monovalent inorganic cation transport|hydrogen ion channel activity - - - - 15:68930525-69062743 21 16 18 72 44 44 0.0980142658574038 0.0678673022740243 0.0757459049842203 0.301088225868831 0.168492854848362 0.19246010691288 0.0805424910385495 0.220680395876691 -1.45413647550064 0.000386050150801077 0.00258817453447459 DOWN ENSG00000185615 PDIA2 protein disulfide isomerase family A member 2 [Source:HGNC Symbol;Acc:HGNC:14180] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0016491|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0006457|GO:0043227|GO:0008289|GO:0016853|GO:0005622|GO:0005515|GO:0012505|GO:0051213|GO:0010941|GO:0005496|GO:0033554|GO:0034975|GO:0043231|GO:0051651|GO:0005737|GO:0016705|GO:0042592|GO:0009966|GO:0019725|GO:0016667|GO:0006979|GO:0010646|GO:0016860|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0008219|GO:0045454|GO:0019538|GO:0055114|GO:1902882|GO:0043412|GO:0015036|GO:0036211|GO:1900407|GO:0034599|GO:0032507|GO:0016706|GO:0034613|GO:0012501|GO:0035556|GO:0044267|GO:0005788|GO:1902531|GO:0034976|GO:0043067|GO:0097190|GO:0051220|GO:0097193|GO:2001242|GO:0033365|GO:0008631|GO:0042981|GO:0003756|GO:0006464|GO:0031543|GO:1902175|GO:0006915|GO:0070972|GO:0031545|GO:0018126|GO:0035437|GO:0018193|GO:0019511|GO:0006621|GO:0018208 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|protein folding|membrane-bounded organelle|lipid binding|isomerase activity|intracellular|protein binding|endomembrane system|dioxygenase activity|regulation of cell death|steroid binding|cellular response to stress|protein folding in endoplasmic reticulum|intracellular membrane-bounded organelle|maintenance of location in cell|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|homeostatic process|regulation of signal transduction|cellular homeostasis|oxidoreductase activity, acting on a sulfur group of donors|response to oxidative stress|regulation of cell communication|intramolecular oxidoreductase activity|protein localization|cell communication|signal transduction|endoplasmic reticulum|cell death|cell redox homeostasis|protein metabolic process|oxidation-reduction process|regulation of response to oxidative stress|macromolecule modification|disulfide oxidoreductase activity|protein modification process|regulation of cellular response to oxidative stress|cellular response to oxidative stress|maintenance of protein location in cell|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|cellular protein localization|programmed cell death|intracellular signal transduction|cellular protein metabolic process|endoplasmic reticulum lumen|regulation of intracellular signal transduction|response to endoplasmic reticulum stress|regulation of programmed cell death|apoptotic signaling pathway|cytoplasmic sequestering of protein|intrinsic apoptotic signaling pathway|regulation of intrinsic apoptotic signaling pathway|protein localization to organelle|intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of apoptotic process|protein disulfide isomerase activity|cellular protein modification process|peptidyl-proline dioxygenase activity|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|apoptotic process|protein localization to endoplasmic reticulum|peptidyl-proline 4-dioxygenase activity|protein hydroxylation|maintenance of protein localization in endoplasmic reticulum|peptidyl-amino acid modification|peptidyl-proline hydroxylation|protein retention in ER lumen|peptidyl-proline modification - - - - 16:283152-287215 7 14 3 0 1 1 0.0982086614660064 0.178505003789562 0.0379414481977928 0 0.0115159118572694 0.0131467166556363 0.104885037817787 0.00822087617096857 3.67337291457808 0.000387175514985855 0.00259513646708301 UP ENSG00000279806 RP11-58O9.2 - - - - - - - 17:40473554-40475289 33 47 40 13 18 22 1.34464687137834 1.74051475943211 1.46950191907535 0.474607733169832 0.601770233713639 0.840148587880762 1.51822118329527 0.638842184921411 1.24885049920669 0.00039201201995265 0.0026257856952359 UP ENSG00000125998 FAM83C family with sequence similarity 83 member C [Source:HGNC Symbol;Acc:HGNC:16121] GO:0005488|GO:0005515|GO:0019899|GO:0019900|GO:0019901 binding|protein binding|enzyme binding|kinase binding|protein kinase binding - - - - 20:35285731-35292401 5 6 2 0 0 0 0.112464529480214 0.122646681231929 0.0405583796481485 0 0 0 0.0918898634534305 0 Inf 0.000392155197319015 0.00262615550936785 UP ENSG00000229956 ZRANB2-AS2 ZRANB2 antisense RNA 2 (head to head) [Source:HGNC Symbol;Acc:HGNC:43595] - - - - - - 1:71081324-71489976 0 0 0 5 3 5 0 0 0 0.0274609761615522 0.0150906977557955 0.0287285937810029 0 0.0237600892327835 -Inf 0.000393290608263262 0.00263196902626797 DOWN ENSG00000253196 RP11-706C16.7 - - - - - - - 8:142763116-142766427 0 0 0 6 2 6 0 0 0 0.567589724837326 0.173236319133988 0.593708938830911 0 0.444844994267408 -Inf 0.000393375956160236 0.00263196902626797 DOWN ENSG00000235721 AC013268.3 - - - - - - - 2:110007675-110010783 138 147 104 54 66 82 4.20038533282662 4.0663785844583 2.85400910610886 1.47264965763554 1.64825543149618 2.33912921190917 3.70692434113126 1.8200114336803 1.0262751560857 0.000395598754362676 0.00264413113012904 UP ENSG00000267940 RP11-290F24.6 - - - - - - - 11:6201901-6203253 28 20 27 10 9 10 1.46386254508316 0.950292713659564 1.27270807814811 0.468446804189466 0.386058065678817 0.489968936088383 1.22895444563028 0.448157935318889 1.45535229238431 0.000397105703314726 0.00265276206461352 UP ENSG00000184194 GPR173 G protein-coupled receptor 173 [Source:HGNC Symbol;Acc:HGNC:18186] GO:0040011|GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0040013|GO:0004872|GO:0048523|GO:0050794|GO:0040012|GO:0038023|GO:0048870|GO:0071944|GO:0031224|GO:0050793|GO:0005886|GO:0048856|GO:0045595|GO:0048468|GO:0007275|GO:0045596|GO:0010243|GO:0004888|GO:0006928|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009725|GO:0051271|GO:0048869|GO:0016021|GO:2000145|GO:0010033|GO:2000146|GO:0050768|GO:0007186|GO:0010721|GO:1901652|GO:0071417|GO:0030334|GO:0001764|GO:0043434|GO:0030336|GO:0007399|GO:0071310|GO:0030154|GO:0004930|GO:0032870|GO:0051960|GO:2001222|GO:1901653|GO:0016500|GO:0071375|GO:2001223|GO:0022008|GO:0050767|GO:0097211|GO:0004968|GO:0048699 locomotion|developmental process|signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|negative regulation of locomotion|receptor activity|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|signaling receptor activity|cell motility|cell periphery|intrinsic component of membrane|regulation of developmental process|plasma membrane|anatomical structure development|regulation of cell differentiation|cell development|multicellular organism development|negative regulation of cell differentiation|response to organonitrogen compound|transmembrane signaling receptor activity|movement of cell or subcellular component|cell communication|regulation of cellular component movement|cell migration|signal transduction|response to hormone|negative regulation of cellular component movement|cellular developmental process|integral component of membrane|regulation of cell motility|response to organic substance|negative regulation of cell motility|negative regulation of neurogenesis|G-protein coupled receptor signaling pathway|negative regulation of cell development|response to peptide|cellular response to organonitrogen compound|regulation of cell migration|neuron migration|response to peptide hormone|negative regulation of cell migration|nervous system development|cellular response to organic substance|cell differentiation|G-protein coupled receptor activity|cellular response to hormone stimulus|regulation of nervous system development|regulation of neuron migration|cellular response to peptide|protein-hormone receptor activity|cellular response to peptide hormone stimulus|negative regulation of neuron migration|neurogenesis|regulation of neurogenesis|cellular response to gonadotropin-releasing hormone|gonadotropin-releasing hormone receptor activity|generation of neurons - - - - X:53049091-53080615 0 0 1 4 7 7 0 0 0.0125878115757987 0.0500638646183528 0.0802267434920354 0.09164114028326 0.0041959371919329 0.0739772494645494 -4.14001667305912 0.0003976526878103 0.00265530055422385 DOWN ENSG00000213999 MEF2B myocyte enhancer factor 2B [Source:HGNC Symbol;Acc:HGNC:6995] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0061061|GO:0043231|GO:0019899|GO:0000981|GO:0005667|GO:0046983|GO:0006139|GO:0044249|GO:0031323|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010628|GO:0042826|GO:0010467|GO:0031328|GO:0009059|GO:0001228|GO:0007517|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|enzyme binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|transcription factor complex|protein dimerization activity|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|positive regulation of gene expression|histone deacetylase binding|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|muscle organ development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09261 MADS-box transcription enhancer factor 2B[-] hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) 19:19145568-19170289 5 3 6 19 16 20 0.107052344193485 0.0583814560820455 0.115819707015824 0.364468565503583 0.281054719100214 0.401288117752774 0.0937511690971182 0.348937134118857 -1.8960585518194 0.000398033267064827 0.00265717467686792 DOWN ENSG00000067715 SYT1 synaptotagmin 1 [Source:HGNC Symbol;Acc:HGNC:11509] GO:0032502|GO:0040007|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0042995|GO:0030672|GO:0008021|GO:0051606|GO:0050794|GO:0060076|GO:0043229|GO:0051050|GO:0016049|GO:0016079|GO:0043167|GO:0051641|GO:0023051|GO:0009653|GO:0072341|GO:0016043|GO:0045927|GO:0043227|GO:0008289|GO:0071944|GO:0040008|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0097060|GO:0031090|GO:0042802|GO:0060341|GO:0031201|GO:0050804|GO:0045595|GO:0051640|GO:0048468|GO:0008022|GO:0006810|GO:0051130|GO:0043195|GO:0007275|GO:0060627|GO:0048513|GO:0005102|GO:0043168|GO:0030307|GO:0032940|GO:0005543|GO:0031982|GO:0051128|GO:0030276|GO:0007420|GO:0050806|GO:0022607|GO:0030141|GO:0045597|GO:0043231|GO:0043169|GO:0030133|GO:0005737|GO:0007267|GO:0042734|GO:0060322|GO:0012506|GO:0051656|GO:0043177|GO:0022406|GO:0043005|GO:0048306|GO:0048639|GO:0030658|GO:0048791|GO:0031340|GO:0010646|GO:0000149|GO:0005516|GO:0001786|GO:0007154|GO:0061024|GO:0009593|GO:0048588|GO:0048638|GO:0051649|GO:0044306|GO:0030667|GO:0001505|GO:0051047|GO:0030030|GO:0048869|GO:0016021|GO:0010035|GO:0001558|GO:0005794|GO:0006996|GO:0060560|GO:0061025|GO:0016192|GO:0006836|GO:0051650|GO:0098746|GO:0000902|GO:0048278|GO:0031175|GO:0070083|GO:0031344|GO:0005513|GO:0046872|GO:0016050|GO:0042583|GO:0030424|GO:0060201|GO:0007417|GO:0031410|GO:0010720|GO:0035091|GO:0048489|GO:0070325|GO:0031346|GO:0045921|GO:0010038|GO:0042584|GO:0016023|GO:0006887|GO:0030665|GO:0070382|GO:0046907|GO:0006811|GO:0043679|GO:0017157|GO:0051046|GO:0050769|GO:0051966|GO:0031988|GO:0022604|GO:0006461|GO:0031045|GO:0005544|GO:0030659|GO:0071241|GO:0033043|GO:0031406|GO:0032990|GO:0031338|GO:0007399|GO:0046903|GO:0051648|GO:0030154|GO:0048858|GO:1903861|GO:0019905|GO:0014047|GO:1990138|GO:0051960|GO:0048284|GO:0060203|GO:0010638|GO:0048666|GO:0030182|GO:0006820|GO:0010975|GO:0015711|GO:0045055|GO:0051259|GO:0051592|GO:0005545|GO:0005509|GO:0046942|GO:0016482|GO:0061202|GO:1903307|GO:0006906|GO:0030135|GO:0097484|GO:1901981|GO:0036465|GO:1903305|GO:0017075|GO:0016597|GO:0006865|GO:0050750|GO:0006897|GO:0022008|GO:0050767|GO:0048812|GO:0046717|GO:0010976|GO:0071248|GO:0045666|GO:0030136|GO:0048488|GO:1902936|GO:0048699|GO:0006835|GO:0071277|GO:0017156|GO:0017158|GO:0006898|GO:0045956|GO:0051260|GO:0045664|GO:0007268|GO:0007270|GO:0072583|GO:0005546|GO:0035249 developmental process|growth|macromolecular complex|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|small molecule binding|cellular response to stimulus|cell projection|synaptic vesicle membrane|synaptic vesicle|detection of stimulus|regulation of cellular process|excitatory synapse|intracellular organelle|positive regulation of transport|cell growth|synaptic vesicle exocytosis|ion binding|cellular localization|regulation of signaling|anatomical structure morphogenesis|modified amino acid binding|cellular component organization|positive regulation of growth|membrane-bounded organelle|lipid binding|cell periphery|regulation of growth|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|neurotransmitter secretion|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|synaptic membrane|organelle membrane|identical protein binding|regulation of cellular localization|SNARE complex|modulation of synaptic transmission|regulation of cell differentiation|organelle localization|cell development|protein C-terminus binding|transport|positive regulation of cellular component organization|terminal bouton|multicellular organism development|regulation of vesicle-mediated transport|animal organ development|receptor binding|anion binding|positive regulation of cell growth|secretion by cell|phospholipid binding|vesicle|regulation of cellular component organization|clathrin binding|brain development|positive regulation of synaptic transmission|cellular component assembly|secretory granule|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|transport vesicle|cytoplasm|cell-cell signaling|presynaptic membrane|head development|vesicle membrane|establishment of organelle localization|organic acid binding|membrane docking|neuron projection|calcium-dependent protein binding|positive regulation of developmental growth|transport vesicle membrane|calcium ion-regulated exocytosis of neurotransmitter|positive regulation of vesicle fusion|regulation of cell communication|SNARE binding|calmodulin binding|phosphatidylserine binding|cell communication|membrane organization|detection of chemical stimulus|developmental cell growth|regulation of developmental growth|establishment of localization in cell|neuron projection terminus|secretory granule membrane|regulation of neurotransmitter levels|positive regulation of secretion|cell projection organization|cellular developmental process|integral component of membrane|response to inorganic substance|regulation of cell growth|Golgi apparatus|organelle organization|developmental growth involved in morphogenesis|membrane fusion|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|fast, calcium ion-dependent exocytosis of neurotransmitter|cell morphogenesis|vesicle docking|neuron projection development|clathrin-sculpted monoamine transport vesicle membrane|regulation of cell projection organization|detection of calcium ion|metal ion binding|vesicle organization|chromaffin granule|axon|clathrin-sculpted acetylcholine transport vesicle membrane|central nervous system development|cytoplasmic vesicle|positive regulation of cell development|phosphatidylinositol binding|synaptic vesicle transport|lipoprotein particle receptor binding|positive regulation of cell projection organization|positive regulation of exocytosis|response to metal ion|chromaffin granule membrane|cytoplasmic, membrane-bounded vesicle|exocytosis|clathrin-coated vesicle membrane|exocytic vesicle|intracellular transport|ion transport|axon terminus|regulation of exocytosis|regulation of secretion|positive regulation of neurogenesis|regulation of synaptic transmission, glutamatergic|membrane-bounded vesicle|regulation of cell morphogenesis|protein complex assembly|dense core granule|calcium-dependent phospholipid binding|cytoplasmic vesicle membrane|cellular response to inorganic substance|regulation of organelle organization|carboxylic acid binding|cell part morphogenesis|regulation of vesicle fusion|nervous system development|secretion|vesicle localization|cell differentiation|cell projection morphogenesis|positive regulation of dendrite extension|syntaxin binding|glutamate secretion|neuron projection extension|regulation of nervous system development|organelle fusion|clathrin-sculpted glutamate transport vesicle membrane|positive regulation of organelle organization|neuron development|neuron differentiation|anion transport|regulation of neuron projection development|organic anion transport|regulated exocytosis|protein oligomerization|response to calcium ion|1-phosphatidylinositol binding|calcium ion binding|carboxylic acid transport|cytosolic transport|clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane|positive regulation of regulated secretory pathway|vesicle fusion|coated vesicle|dendrite extension|phosphatidylinositol phosphate binding|synaptic vesicle recycling|regulation of regulated secretory pathway|syntaxin-1 binding|amino acid binding|amino acid transport|low-density lipoprotein particle receptor binding|endocytosis|neurogenesis|regulation of neurogenesis|neuron projection morphogenesis|acid secretion|positive regulation of neuron projection development|cellular response to metal ion|positive regulation of neuron differentiation|clathrin-coated vesicle|synaptic vesicle endocytosis|phosphatidylinositol bisphosphate binding|generation of neurons|dicarboxylic acid transport|cellular response to calcium ion|calcium ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|receptor-mediated endocytosis|positive regulation of calcium ion-dependent exocytosis|protein homooligomerization|regulation of neuron differentiation|synaptic transmission|neuron-neuron synaptic transmission|clathrin-mediated endocytosis|phosphatidylinositol-4,5-bisphosphate binding|synaptic transmission, glutamatergic K15290 synaptotagmin-1[-] hsa04721 Synaptic vesicle cycle - Homo sapiens (human) 12:78863993-79452008 0 1 2 8 5 14 0 0.0046607048360101 0.00924319594155268 0.036742523250339 0.0210289779147751 0.0672566281731056 0.00463463359252093 0.0416760431127399 -3.1686911179108 0.000398474675095132 0.00265952670473733 DOWN ENSG00000197961 ZNF121 zinc finger protein 121 [Source:HGNC Symbol;Acc:HGNC:12904] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:9560353-9584533 312 1339 711 293 391 365 2.41888048597775 9.43454501949229 4.96986265601413 2.03528942248884 2.48716565952566 2.65205274913792 5.60776272049472 2.39150261038414 1.22950794027484 0.000399480817352417 0.00266564602620453 UP ENSG00000053254 FOXN3 forkhead box N3 [Source:HGNC Symbol;Acc:HGNC:1928] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0008022|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0033554|GO:0045786|GO:0043231|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0000075|GO:0034645|GO:1903047|GO:0010629|GO:0051252|GO:0044770|GO:0000278|GO:0007346|GO:0010564|GO:0045930|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0006974|GO:0010948|GO:0045892|GO:0007093|GO:0000086|GO:0032774|GO:0044772|GO:0043565|GO:2001141|GO:0044774|GO:1902679|GO:0000077|GO:1901990|GO:0007095|GO:1901987|GO:0006351|GO:0006355|GO:0044773|GO:1901991|GO:1903507|GO:0010389|GO:0044818|GO:0010972|GO:1903506|GO:1902750|GO:1902749|GO:0031572 cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|protein C-terminus binding|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|negative regulation of cell cycle|intracellular membrane-bounded organelle|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|mitotic cell cycle process|negative regulation of gene expression|regulation of RNA metabolic process|cell cycle phase transition|mitotic cell cycle|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|negative regulation of cell cycle process|negative regulation of transcription, DNA-templated|mitotic cell cycle checkpoint|G2/M transition of mitotic cell cycle|RNA biosynthetic process|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of RNA biosynthetic process|mitotic DNA integrity checkpoint|negative regulation of RNA biosynthetic process|DNA damage checkpoint|regulation of mitotic cell cycle phase transition|mitotic G2 DNA damage checkpoint|regulation of cell cycle phase transition|transcription, DNA-templated|regulation of transcription, DNA-templated|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|negative regulation of nucleic acid-templated transcription|regulation of G2/M transition of mitotic cell cycle|mitotic G2/M transition checkpoint|negative regulation of G2/M transition of mitotic cell cycle|regulation of nucleic acid-templated transcription|negative regulation of cell cycle G2/M phase transition|regulation of cell cycle G2/M phase transition|G2 DNA damage checkpoint - - - - 14:89124871-89619149 18 12 41 54 61 131 0.0663368966351917 0.0401921238381178 0.136230072383799 0.178307690129467 0.184450647471774 0.452458601424252 0.0809196976190362 0.271738979675164 -1.74765869425245 0.000400438851396718 0.00266965195837374 DOWN ENSG00000233198 RNF224 ring finger protein 224 [Source:HGNC Symbol;Acc:HGNC:41912] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|protein binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 9:137227271-137229638 31 12 35 74 67 83 1.21959946763986 0.429058745800241 1.24148968059405 2.60848434732018 2.16270897054091 3.06030146488021 0.963382631344717 2.61049826091377 -1.43814437840009 0.000400383789863595 0.00266965195837374 DOWN ENSG00000235493 AC092415.1 - - - - - - - 3:27997210-28028604 0 0 0 4 4 6 0 0 0 0.199624732619952 0.182784777668932 0.313216526784811 0 0.231875345691232 -Inf 0.000401967083093185 0.00267864403988035 DOWN ENSG00000167874 TMEM88 transmembrane protein 88 [Source:HGNC Symbol;Acc:HGNC:32371] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0051641|GO:0023051|GO:0016043|GO:0071944|GO:0023057|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0007275|GO:0005737|GO:0009966|GO:0019904|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0009968|GO:0031647|GO:0016021|GO:0010256|GO:0030111|GO:0005829|GO:0030178|GO:0007166|GO:0050821|GO:0030165|GO:0007009|GO:0072657|GO:0034613|GO:0016055|GO:0090090|GO:0060828|GO:0072659|GO:1990778|GO:0060070 developmental process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|cellular localization|regulation of signaling|cellular component organization|cell periphery|negative regulation of signaling|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|multicellular organism development|cytoplasm|regulation of signal transduction|protein domain specific binding|regulation of cell communication|protein localization|cell communication|membrane organization|signal transduction|negative regulation of signal transduction|regulation of protein stability|integral component of membrane|endomembrane system organization|regulation of Wnt signaling pathway|cytosol|negative regulation of Wnt signaling pathway|cell surface receptor signaling pathway|protein stabilization|PDZ domain binding|plasma membrane organization|protein localization to membrane|cellular protein localization|Wnt signaling pathway|negative regulation of canonical Wnt signaling pathway|regulation of canonical Wnt signaling pathway|protein localization to plasma membrane|protein localization to cell periphery|canonical Wnt signaling pathway - - - - 17:7855065-7856099 8 12 8 2 2 1 0.408569316668101 0.557001895269916 0.368393080125421 0.0915246969051765 0.0838038511334091 0.0478597439550311 0.444654764021146 0.0743960973312056 2.5793867951663 0.000402614290537719 0.00268175971211804 UP ENSG00000164258 NDUFS4 NADH:ubiquinone oxidoreductase subunit S4 [Source:HGNC Symbol;Acc:HGNC:7711] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0070469|GO:0043227|GO:0005622|GO:0043234|GO:0048856|GO:0031090|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:0019866|GO:1901360|GO:0005746|GO:0007275|GO:0048513|GO:0034641|GO:0015980|GO:0044281|GO:0019637|GO:0046483|GO:0007420|GO:0022607|GO:0043231|GO:0010243|GO:0048144|GO:0005737|GO:0060322|GO:0072593|GO:0031966|GO:0006139|GO:0016651|GO:0055086|GO:0045271|GO:0007154|GO:0007165|GO:0006091|GO:0022900|GO:0019538|GO:0010033|GO:0031323|GO:0006996|GO:0055114|GO:0032268|GO:0005740|GO:0014074|GO:0043412|GO:0007417|GO:0019693|GO:0007005|GO:0046683|GO:0097031|GO:0005747|GO:0036211|GO:0009116|GO:0022904|GO:0048145|GO:0005743|GO:0048146|GO:0005739|GO:0016655|GO:0051591|GO:0006461|GO:0014070|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0007399|GO:0006119|GO:0045333|GO:0051246|GO:0003954|GO:0034622|GO:0032981|GO:0009259|GO:0009117|GO:0042773|GO:0043623|GO:0016310|GO:0006163|GO:0033108|GO:0006464|GO:0019932|GO:0006120|GO:0042278|GO:0019935|GO:0006468|GO:0042775|GO:0042325|GO:0001932|GO:0010257|GO:0008137|GO:0046034|GO:0019933 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|respiratory chain|membrane-bounded organelle|intracellular|protein complex|anatomical structure development|organelle membrane|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|organelle inner membrane|organic cyclic compound metabolic process|mitochondrial respiratory chain|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|brain development|cellular component assembly|intracellular membrane-bounded organelle|response to organonitrogen compound|fibroblast proliferation|cytoplasm|head development|reactive oxygen species metabolic process|mitochondrial membrane|nucleobase-containing compound metabolic process|oxidoreductase activity, acting on NAD(P)H|nucleobase-containing small molecule metabolic process|respiratory chain complex I|cell communication|signal transduction|generation of precursor metabolites and energy|electron transport chain|protein metabolic process|response to organic substance|regulation of cellular metabolic process|organelle organization|oxidation-reduction process|regulation of cellular protein metabolic process|mitochondrial envelope|response to purine-containing compound|macromolecule modification|central nervous system development|ribose phosphate metabolic process|mitochondrion organization|response to organophosphorus|mitochondrial respiratory chain complex I biogenesis|mitochondrial respiratory chain complex I|protein modification process|nucleoside metabolic process|respiratory electron transport chain|regulation of fibroblast proliferation|mitochondrial inner membrane|positive regulation of fibroblast proliferation|mitochondrion|oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor|response to cAMP|protein complex assembly|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|oxidative phosphorylation|cellular respiration|regulation of protein metabolic process|NADH dehydrogenase activity|cellular macromolecular complex assembly|mitochondrial respiratory chain complex I assembly|ribonucleotide metabolic process|nucleotide metabolic process|ATP synthesis coupled electron transport|cellular protein complex assembly|phosphorylation|purine nucleotide metabolic process|mitochondrial respiratory chain complex assembly|cellular protein modification process|second-messenger-mediated signaling|mitochondrial electron transport, NADH to ubiquinone|purine nucleoside metabolic process|cyclic-nucleotide-mediated signaling|protein phosphorylation|mitochondrial ATP synthesis coupled electron transport|regulation of phosphorylation|regulation of protein phosphorylation|NADH dehydrogenase complex assembly|NADH dehydrogenase (ubiquinone) activity|ATP metabolic process|cAMP-mediated signaling K03937 NADH dehydrogenase (ubiquinone) Fe-S protein 4[-] hsa01100|hsa05016|hsa05010|hsa04932|hsa05012|hsa00190 Metabolic pathways - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)|Parkinson,s disease - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human) 5:53560633-53683340 257 249 181 613 488 411 8.3315095964893 7.33619094516323 5.29034236655056 17.8052924952533 12.9801327121393 12.4871203808487 6.98601430273436 14.4241818627471 -1.04594799022971 0.000403670837660588 0.00268699870401766 DOWN ENSG00000197046 SIGLEC15 sialic acid binding Ig-like lectin 15 [Source:HGNC Symbol;Acc:HGNC:27596] GO:0032502|GO:0032991|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0006955|GO:0016043|GO:0071944|GO:0031224|GO:0050793|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:1903706|GO:0045087|GO:0045595|GO:0048468|GO:0007275|GO:0048513|GO:0006952|GO:0051128|GO:0055094|GO:0032970|GO:0042592|GO:0048771|GO:0048871|GO:0045124|GO:0060348|GO:0034103|GO:0048869|GO:0016021|GO:0030029|GO:0010033|GO:0006996|GO:0046850|GO:0032956|GO:0007010|GO:0030097|GO:0001894|GO:0071402|GO:0046849|GO:1903010|GO:0030036|GO:0033043|GO:0071310|GO:0030154|GO:0001501|GO:0045637|GO:0002521|GO:0002761|GO:2001204|GO:0036035|GO:0051493|GO:0045453|GO:0030099|GO:0002573|GO:0045670|GO:0030316 developmental process|macromolecular complex|immune system process|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|immune response|cellular component organization|cell periphery|intrinsic component of membrane|regulation of developmental process|regulation of immune system process|immune system development|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of hemopoiesis|innate immune response|regulation of cell differentiation|cell development|multicellular organism development|animal organ development|defense response|regulation of cellular component organization|response to lipoprotein particle|regulation of actin filament-based process|homeostatic process|tissue remodeling|multicellular organismal homeostasis|regulation of bone resorption|bone development|regulation of tissue remodeling|cellular developmental process|integral component of membrane|actin filament-based process|response to organic substance|organelle organization|regulation of bone remodeling|regulation of actin cytoskeleton organization|cytoskeleton organization|hemopoiesis|tissue homeostasis|cellular response to lipoprotein particle stimulus|bone remodeling|regulation of bone development|actin cytoskeleton organization|regulation of organelle organization|cellular response to organic substance|cell differentiation|skeletal system development|regulation of myeloid cell differentiation|leukocyte differentiation|regulation of myeloid leukocyte differentiation|regulation of osteoclast development|osteoclast development|regulation of cytoskeleton organization|bone resorption|myeloid cell differentiation|myeloid leukocyte differentiation|regulation of osteoclast differentiation|osteoclast differentiation - - - - 18:45825512-45844080 8 6 4 30 34 13 0.111655190131279 0.0761096709696955 0.0503378468798055 0.375169980266968 0.3893602836689 0.17005835110717 0.0793675693269267 0.311529538347679 -1.97274743400326 0.000405508107766545 0.00269802519484342 DOWN ENSG00000279530 AC092881.1 - - - - - - - 12:70321677-70324274 3 2 6 16 10 35 0.0816912314545589 0.0494898399376978 0.147293422625204 0.390311594879642 0.22340253673895 0.893103600932156 0.0928248313391536 0.502272577516916 -2.43588781675812 0.000407141130481683 0.00270768351735356 DOWN ENSG00000224221 RPS6P8 ribosomal protein S6 pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:36999] - - - - - - 6:73391038-73391767 5 9 8 1 1 1 0.484521842760649 0.792624853930815 0.698937556128367 0.0867791691791946 0.0795386679237705 0.090802390928381 0.658694750939944 0.0857067426771154 2.9421294406217 0.000407573248385686 0.00270995362078091 UP ENSG00000280347 AC000123.2 - - - - - - - 7:127359785-127364759 33 70 93 144 146 194 0.469207430897044 0.904544953876355 1.19219938991156 1.83447682096964 1.70323006680054 2.58513698262041 0.85531725822832 2.04094795679686 -1.25470783931056 0.000407868752716405 0.00271131457216557 DOWN ENSG00000169031 COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) [Source:HGNC Symbol;Acc:HGNC:2204] GO:0040011|GO:0032502|GO:0031012|GO:0032991|GO:0005198|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0005604|GO:0051716|GO:0009892|GO:0005201|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0005578|GO:0071704|GO:0009056|GO:0044237|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0009605|GO:0009893|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0005587|GO:0042127|GO:0004857|GO:0006935|GO:0001822|GO:0048468|GO:0001568|GO:0010941|GO:0032835|GO:0007275|GO:0048513|GO:0050877|GO:0005102|GO:0043062|GO:0031325|GO:0032836|GO:0010942|GO:0043231|GO:0005737|GO:0006928|GO:0032403|GO:0072006|GO:0050839|GO:0044236|GO:0043085|GO:0001525|GO:0007154|GO:0044092|GO:0007165|GO:0005783|GO:0008219|GO:0008285|GO:0050790|GO:0030030|GO:0043086|GO:0048869|GO:0005581|GO:0019538|GO:0031324|GO:0031323|GO:0003013|GO:0016525|GO:0032268|GO:0000902|GO:0031175|GO:0030574|GO:0044259|GO:0007166|GO:0001944|GO:0022617|GO:0072358|GO:0051345|GO:0001655|GO:0030414|GO:0051604|GO:0000904|GO:0032269|GO:0005178|GO:0072001|GO:0007600|GO:0045765|GO:0051247|GO:0051346|GO:0006508|GO:0032270|GO:0012501|GO:1901342|GO:0044267|GO:0010467|GO:0032990|GO:0005788|GO:0007399|GO:0097485|GO:0030198|GO:0051246|GO:0030154|GO:0048858|GO:0043068|GO:0072359|GO:0008015|GO:0043067|GO:0048666|GO:0030182|GO:0008191|GO:0007411|GO:0004866|GO:0010466|GO:0043065|GO:0050954|GO:0016485|GO:0030162|GO:0045862|GO:0052547|GO:0061564|GO:0042981|GO:0045861|GO:0022008|GO:0048667|GO:0048812|GO:0010952|GO:0006915|GO:0032963|GO:0010950|GO:0007605|GO:0007409|GO:0043281|GO:0048699|GO:0010951|GO:0031638|GO:0043280|GO:0006919|GO:0052548|GO:0072577|GO:2001056|GO:2000116|GO:0097202 locomotion|developmental process|extracellular matrix|macromolecular complex|structural molecule activity|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|basement membrane|cellular response to stimulus|negative regulation of metabolic process|extracellular matrix structural constituent|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|organic substance metabolic process|catabolic process|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|collagen type IV trimer|regulation of cell proliferation|enzyme inhibitor activity|chemotaxis|kidney development|cell development|blood vessel development|regulation of cell death|glomerulus development|multicellular organism development|animal organ development|neurological system process|receptor binding|extracellular structure organization|positive regulation of cellular metabolic process|glomerular basement membrane development|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|protein complex binding|nephron development|cell adhesion molecule binding|multicellular organism metabolic process|positive regulation of catalytic activity|angiogenesis|cell communication|negative regulation of molecular function|signal transduction|endoplasmic reticulum|cell death|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|cellular developmental process|collagen trimer|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|negative regulation of angiogenesis|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|collagen catabolic process|multicellular organismal macromolecule metabolic process|cell surface receptor signaling pathway|vasculature development|extracellular matrix disassembly|cardiovascular system development|positive regulation of hydrolase activity|urogenital system development|peptidase inhibitor activity|protein maturation|cell morphogenesis involved in differentiation|negative regulation of cellular protein metabolic process|integrin binding|renal system development|sensory perception|regulation of angiogenesis|positive regulation of protein metabolic process|negative regulation of hydrolase activity|proteolysis|positive regulation of cellular protein metabolic process|programmed cell death|regulation of vasculature development|cellular protein metabolic process|gene expression|cell part morphogenesis|endoplasmic reticulum lumen|nervous system development|neuron projection guidance|extracellular matrix organization|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|circulatory system development|blood circulation|regulation of programmed cell death|neuron development|neuron differentiation|metalloendopeptidase inhibitor activity|axon guidance|endopeptidase inhibitor activity|negative regulation of peptidase activity|positive regulation of apoptotic process|sensory perception of mechanical stimulus|protein processing|regulation of proteolysis|positive regulation of proteolysis|regulation of peptidase activity|axon development|regulation of apoptotic process|negative regulation of proteolysis|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|positive regulation of peptidase activity|apoptotic process|collagen metabolic process|positive regulation of endopeptidase activity|sensory perception of sound|axonogenesis|regulation of cysteine-type endopeptidase activity involved in apoptotic process|generation of neurons|negative regulation of endopeptidase activity|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of endopeptidase activity|endothelial cell apoptotic process|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity K06237 collagen, type IV, alpha[-] hsa05200|hsa04151|hsa04510|hsa04933|hsa05146|hsa04974|hsa05222|hsa04512 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Protein digestion and absorption - Homo sapiens (human)|Small cell lung cancer - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human) 2:227164565-227314792 5 6 19 28 29 57 0.0354872022890814 0.0387000915495552 0.121576162713022 0.178047532334637 0.168865056928874 0.379129236859912 0.0652544855172195 0.242013942041141 -1.89094118189968 0.000411427731550729 0.00273132388208038 DOWN ENSG00000166396 SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 [Source:HGNC Symbol;Acc:HGNC:13902] GO:0032502|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0071704|GO:0044237|GO:0009893|GO:0009058|GO:0005615|GO:0030234|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0004857|GO:0001822|GO:0009888|GO:0001568|GO:0032835|GO:0007275|GO:0048513|GO:0001817|GO:0072111|GO:0005737|GO:0001816|GO:0072006|GO:0001819|GO:0044236|GO:0044092|GO:0050790|GO:0043086|GO:0090184|GO:0019538|GO:0031324|GO:0031323|GO:1901724|GO:0032268|GO:0044259|GO:0071636|GO:0010712|GO:0001944|GO:0072358|GO:0032964|GO:0001655|GO:0030414|GO:0072110|GO:0072126|GO:0032269|GO:0072001|GO:0072012|GO:0051346|GO:0006508|GO:0090362|GO:0090193|GO:1901342|GO:0044267|GO:0051246|GO:0009059|GO:0061448|GO:0010714|GO:0072359|GO:0010557|GO:0090361|GO:0004866|GO:0010466|GO:0030162|GO:0032967|GO:0052547|GO:0032914|GO:0045861|GO:0032963|GO:0010951|GO:0004867|GO:0052548 developmental process|cell|cellular process|extracellular region|metabolic process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|organic substance metabolic process|cellular metabolic process|positive regulation of metabolic process|biosynthetic process|extracellular space|enzyme regulator activity|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|enzyme inhibitor activity|kidney development|tissue development|blood vessel development|glomerulus development|multicellular organism development|animal organ development|regulation of cytokine production|cell proliferation involved in kidney development|cytoplasm|cytokine production|nephron development|positive regulation of cytokine production|multicellular organism metabolic process|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|positive regulation of kidney development|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of cell proliferation involved in kidney development|regulation of cellular protein metabolic process|multicellular organismal macromolecule metabolic process|positive regulation of transforming growth factor beta production|regulation of collagen metabolic process|vasculature development|cardiovascular system development|collagen biosynthetic process|urogenital system development|peptidase inhibitor activity|glomerular mesangial cell proliferation|positive regulation of glomerular mesangial cell proliferation|negative regulation of cellular protein metabolic process|renal system development|glomerulus vasculature development|negative regulation of hydrolase activity|proteolysis|positive regulation of platelet-derived growth factor production|positive regulation of glomerulus development|regulation of vasculature development|cellular protein metabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|connective tissue development|positive regulation of collagen metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|regulation of platelet-derived growth factor production|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of proteolysis|positive regulation of collagen biosynthetic process|regulation of peptidase activity|positive regulation of transforming growth factor beta1 production|negative regulation of proteolysis|collagen metabolic process|negative regulation of endopeptidase activity|serine-type endopeptidase inhibitor activity|regulation of endopeptidase activity - - - - 18:63752935-63805376 85 75 124 200 213 188 1.40253114645768 1.12469747622768 1.84471150047382 2.95678136083103 2.88362965042342 2.90722451586654 1.45731337438639 2.91587850904033 -1.00061946890647 0.000411550774764397 0.00273153331031932 DOWN ENSG00000223510 CDRT15 CMT1A duplicated region transcript 15 [Source:HGNC Symbol;Acc:HGNC:14395] - - - - - - 17:14235673-14236862 16 11 20 4 6 4 1.2130796014143 0.757975077735942 1.36716081450618 0.271729271626301 0.373210076590906 0.284183259925908 1.11273849788547 0.309707536047705 1.84513619472565 0.000413057719912863 0.00274031670450636 UP ENSG00000174353 STAG3L3 stromal antigen 3-like 3 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:33845] - - - - - - 7:72969696-73005922 59 63 42 131 133 124 0.765067986492022 0.742462045030109 0.491037843356229 1.52201707782606 1.41504974369013 1.50696428562659 0.66618929162612 1.48134370238093 -1.15290234522854 0.000414594245991576 0.00274806763317774 DOWN ENSG00000277203 F8A1 coagulation factor VIII-associated 1 [Source:HGNC Symbol;Acc:HGNC:3547] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|nucleus - - - - X:154886349-154888061 73 89 58 38 38 34 3.01446702191313 3.34010525960015 2.15940470954795 1.40595929996945 1.28749136405281 1.31581868642383 2.83799233035374 1.33642311681536 1.0864938474764 0.00041527751942699 0.00275198558600963 UP ENSG00000180113 TDRD6 tudor domain containing 6 [Source:HGNC Symbol;Acc:HGNC:21339] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0009892|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0032504|GO:0005622|GO:0048856|GO:0048609|GO:0019222|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0005737|GO:0030529|GO:0016458|GO:0006139|GO:0007276|GO:0035770|GO:0010468|GO:0048232|GO:0031047|GO:0010629|GO:0010467|GO:0016070|GO:0036464|GO:0007283|GO:0034660|GO:0033391|GO:0034587 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|negative regulation of metabolic process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|multicellular organism reproduction|intracellular|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cytoplasm|intracellular ribonucleoprotein complex|gene silencing|nucleobase-containing compound metabolic process|gamete generation|ribonucleoprotein granule|regulation of gene expression|male gamete generation|gene silencing by RNA|negative regulation of gene expression|gene expression|RNA metabolic process|cytoplasmic ribonucleoprotein granule|spermatogenesis|ncRNA metabolic process|chromatoid body|piRNA metabolic process - - - - 6:46687875-46704319 42 62 103 19 12 41 0.186301007444706 0.249941225867079 0.41192528279784 0.0755128952419789 0.0436739276520702 0.170443854282213 0.282722505369875 0.096543559058754 1.55013481208937 0.000415609551424725 0.00275296373379937 UP ENSG00000123545 NDUFAF4 NADH:ubiquinone oxidoreductase complex assembly factor 4 [Source:HGNC Symbol;Acc:HGNC:21034] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0044237|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0031090|GO:0019866|GO:0015980|GO:0044281|GO:0022607|GO:0043231|GO:0005737|GO:0031966|GO:0005516|GO:0006091|GO:0022900|GO:0006996|GO:0055114|GO:0005740|GO:0007005|GO:0097031|GO:0022904|GO:0005743|GO:0005739|GO:0006461|GO:0045333|GO:0034622|GO:0032981|GO:0043623|GO:0033108|GO:0010257 cell|membrane|cellular process|metabolic process|binding|intracellular organelle|cellular metabolic process|cellular component organization|membrane-bounded organelle|intracellular|protein binding|organelle membrane|organelle inner membrane|energy derivation by oxidation of organic compounds|small molecule metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|calmodulin binding|generation of precursor metabolites and energy|electron transport chain|organelle organization|oxidation-reduction process|mitochondrial envelope|mitochondrion organization|mitochondrial respiratory chain complex I biogenesis|respiratory electron transport chain|mitochondrial inner membrane|mitochondrion|protein complex assembly|cellular respiration|cellular macromolecular complex assembly|mitochondrial respiratory chain complex I assembly|cellular protein complex assembly|mitochondrial respiratory chain complex assembly|NADH dehydrogenase complex assembly - - - - 6:96889313-96897881 547 482 355 312 269 152 11.1379047520843 8.91955683691054 6.51716784623677 5.69205090132757 4.49403170515675 2.9006052386069 8.85820981174387 4.36222928169707 1.02194956769093 0.000420192483534877 0.00278041463802054 UP ENSG00000212939 RP1-29C18.10 - - - - - - - 22:49548681-49556473 2 3 2 13 8 22 0.0363295135840601 0.0495357809180992 0.0327570888529602 0.211586806569807 0.11924279831228 0.374550063831793 0.0395407944517065 0.23512655623796 -2.57202372955236 0.000424691521311313 0.0028087595651812 DOWN ENSG00000236526 RP4-742J24.2 - - - - - - - 20:11909404-11918677 0 1 4 8 10 13 0 0.0351271036247621 0.139329441827883 0.276923441209545 0.316985139512721 0.470702197384565 0.0581521818175484 0.354870259368944 -2.6093864449969 0.000430274564389399 0.00284253526118192 DOWN ENSG00000236833 AC024560.2 - - - - - - - 3:197660565-197665757 59 63 134 34 23 48 2.83714878743303 2.75331778085605 5.80969321719809 1.46491153665556 0.907459565568167 2.16324872782657 3.80005326182906 1.51187327668343 1.32968241987615 0.000431200247435047 0.00284739044170004 UP ENSG00000189030 VHLL von Hippel-Lindau tumor suppressor-like [Source:HGNC Symbol;Acc:HGNC:30666] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0043231|GO:0005737|GO:0019787|GO:0000151|GO:0019538|GO:0043412|GO:0004842|GO:0036211|GO:1990234|GO:0044267|GO:0000153|GO:0005634|GO:0061630|GO:0006464|GO:0030891|GO:0032446|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|transferase activity|intracellular membrane-bounded organelle|cytoplasm|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|macromolecule modification|ubiquitin-protein transferase activity|protein modification process|transferase complex|cellular protein metabolic process|cytoplasmic ubiquitin ligase complex|nucleus|ubiquitin protein ligase activity|cellular protein modification process|VCB complex|protein modification by small protein conjugation|protein ubiquitination - - - - 1:156298624-156299299 9 6 1 0 0 0 0.941768042911146 0.570597355731386 0.0942968606802433 0 0 0 0.535554086440925 0 Inf 0.000433877974592813 0.00286190743559298 UP ENSG00000143768 LEFTY2 left-right determination factor 2 [Source:HGNC Symbol;Acc:HGNC:3122] GO:0032502|GO:0031012|GO:0040007|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0016049|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0050817|GO:0048468|GO:0006810|GO:0010941|GO:0007275|GO:0005102|GO:0032940|GO:0031982|GO:0031325|GO:0030141|GO:0043231|GO:0005737|GO:0009611|GO:0071559|GO:0001775|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0008219|GO:0031983|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0050878|GO:0000165|GO:0016192|GO:0032268|GO:0005126|GO:0030168|GO:0007166|GO:0043412|GO:0031410|GO:0007596|GO:0005125|GO:0016023|GO:0006887|GO:0036211|GO:0071560|GO:0042060|GO:0007599|GO:0051247|GO:0070848|GO:0031988|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0060205|GO:0044267|GO:0051174|GO:0046903|GO:0071310|GO:0060395|GO:0051246|GO:0030154|GO:0034774|GO:1902531|GO:0008083|GO:0031091|GO:0043067|GO:0060393|GO:0045055|GO:0031401|GO:0043408|GO:0071363|GO:0016310|GO:0007179|GO:0007167|GO:0010862|GO:0042981|GO:0005160|GO:0006464|GO:0031093|GO:0006915|GO:0006468|GO:0042325|GO:0001932|GO:0001934|GO:0007178|GO:0002576|GO:0042327|GO:0060389 developmental process|extracellular matrix|growth|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|cell growth|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|extracellular space|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|coagulation|cell development|transport|regulation of cell death|multicellular organism development|receptor binding|secretion by cell|vesicle|positive regulation of cellular metabolic process|secretory granule|intracellular membrane-bounded organelle|cytoplasm|response to wounding|response to transforming growth factor beta|cell activation|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|cell death|vesicle lumen|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|MAPK cascade|vesicle-mediated transport|regulation of cellular protein metabolic process|cytokine receptor binding|platelet activation|cell surface receptor signaling pathway|macromolecule modification|cytoplasmic vesicle|blood coagulation|cytokine activity|cytoplasmic, membrane-bounded vesicle|exocytosis|protein modification process|cellular response to transforming growth factor beta stimulus|wound healing|hemostasis|positive regulation of protein metabolic process|response to growth factor|membrane-bounded vesicle|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic membrane-bounded vesicle lumen|cellular protein metabolic process|regulation of phosphorus metabolic process|secretion|cellular response to organic substance|SMAD protein signal transduction|regulation of protein metabolic process|cell differentiation|secretory granule lumen|regulation of intracellular signal transduction|growth factor activity|platelet alpha granule|regulation of programmed cell death|regulation of pathway-restricted SMAD protein phosphorylation|regulated exocytosis|positive regulation of protein modification process|regulation of MAPK cascade|cellular response to growth factor stimulus|phosphorylation|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of apoptotic process|transforming growth factor beta receptor binding|cellular protein modification process|platelet alpha granule lumen|apoptotic process|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|platelet degranulation|positive regulation of phosphorylation|pathway-restricted SMAD protein phosphorylation K04668 left-right determination factor[-] hsa04550|hsa04350 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human) 1:225936598-225941489 9 5 6 0 0 2 0.104280949550849 0.0526563366180536 0.0626811321835022 0 0 0.0217152319009723 0.0732061394508016 0.00723841063365743 3.33821978659608 0.000442894304791258 0.00291880056848526 UP ENSG00000167723 TRPV3 transient receptor potential cation channel, subfamily V, member 3 [Source:HGNC Symbol;Acc:HGNC:18084] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0022857|GO:0050794|GO:0051050|GO:0006950|GO:0009628|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0006810|GO:0043270|GO:0042636|GO:0009408|GO:0043235|GO:0022891|GO:0055085|GO:0016021|GO:0042634|GO:0009266|GO:0034767|GO:0015267|GO:0006811|GO:0015075|GO:0034765|GO:0043269|GO:0051928|GO:0034220|GO:0042633|GO:0098655|GO:0005216|GO:0090280|GO:0006812|GO:0090279|GO:0008324|GO:0022890|GO:0030001|GO:0051924|GO:0005261|GO:0005262|GO:0070588|GO:0046873|GO:0006816|GO:0015085|GO:0070509 macromolecular complex|transporter activity|cell|membrane|cellular process|response to stimulus|binding|transmembrane transporter activity|regulation of cellular process|positive regulation of transport|response to stress|response to abiotic stimulus|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|protein complex|transport|positive regulation of ion transport|negative regulation of hair cycle|response to heat|receptor complex|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|regulation of hair cycle|response to temperature stimulus|positive regulation of ion transmembrane transport|channel activity|ion transport|ion transmembrane transporter activity|regulation of ion transmembrane transport|regulation of ion transport|positive regulation of calcium ion transport|ion transmembrane transport|hair cycle|cation transmembrane transport|ion channel activity|positive regulation of calcium ion import|cation transport|regulation of calcium ion import|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|metal ion transport|regulation of calcium ion transport|cation channel activity|calcium channel activity|calcium ion transmembrane transport|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity|calcium ion import K04972 transient receptor potential cation channel subfamily V member 3[-] hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) 17:3510502-3557995 4 6 7 16 35 17 0.0178136530751533 0.0242853247166415 0.0281063394698814 0.0638437022915891 0.127894046793322 0.0709562869056231 0.0234017724205587 0.0875646786635114 -1.90373123929819 0.000443075676639271 0.00291935141257753 DOWN ENSG00000213398 LCAT lecithin-cholesterol acyltransferase [Source:HGNC Symbol;Acc:HGNC:6522] GO:0032991|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0032994|GO:0034358|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0097006|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005615|GO:0005515|GO:0016740|GO:0044255|GO:0034185|GO:0006810|GO:1901360|GO:0034641|GO:0016788|GO:0044281|GO:0031982|GO:0019637|GO:0051128|GO:0022607|GO:0034364|GO:0016746|GO:0042592|GO:0006629|GO:0034369|GO:0090107|GO:0070062|GO:0009725|GO:0016021|GO:0010035|GO:0044249|GO:0010876|GO:0034377|GO:0019538|GO:0010033|GO:0008654|GO:0034645|GO:0046486|GO:0033993|GO:0034370|GO:0034186|GO:0048878|GO:0006066|GO:0009308|GO:0034380|GO:0010038|GO:0046470|GO:0042157|GO:0006869|GO:0046688|GO:0016747|GO:0008202|GO:0014070|GO:0016298|GO:0006796|GO:0034375|GO:0008610|GO:0009059|GO:0030258|GO:0052689|GO:0006644|GO:0048545|GO:0004620|GO:0006656|GO:0046474|GO:0034372|GO:0065005|GO:0004623|GO:0006576|GO:0016125|GO:0042158|GO:0015918|GO:0055088|GO:0031960|GO:0006650|GO:0008374|GO:0051384|GO:0004607|GO:0030301|GO:0008203|GO:0055092|GO:0043691|GO:0042632|GO:0034435 macromolecular complex|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|protein-lipid complex|plasma lipoprotein particle|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of plasma lipoprotein particle levels|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|extracellular space|protein binding|transferase activity|cellular lipid metabolic process|apolipoprotein binding|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|organophosphate metabolic process|regulation of cellular component organization|cellular component assembly|high-density lipoprotein particle|transferase activity, transferring acyl groups|homeostatic process|lipid metabolic process|plasma lipoprotein particle remodeling|regulation of high-density lipoprotein particle assembly|extracellular exosome|response to hormone|integral component of membrane|response to inorganic substance|cellular biosynthetic process|lipid localization|plasma lipoprotein particle assembly|protein metabolic process|response to organic substance|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|glycerolipid metabolic process|response to lipid|triglyceride-rich lipoprotein particle remodeling|apolipoprotein A-I binding|chemical homeostasis|alcohol metabolic process|amine metabolic process|high-density lipoprotein particle assembly|response to metal ion|phosphatidylcholine metabolic process|lipoprotein metabolic process|lipid transport|response to copper ion|transferase activity, transferring acyl groups other than amino-acyl groups|steroid metabolic process|response to organic cyclic compound|lipase activity|phosphate-containing compound metabolic process|high-density lipoprotein particle remodeling|lipid biosynthetic process|macromolecule biosynthetic process|lipid modification|carboxylic ester hydrolase activity|phospholipid metabolic process|response to steroid hormone|phospholipase activity|phosphatidylcholine biosynthetic process|glycerophospholipid biosynthetic process|very-low-density lipoprotein particle remodeling|protein-lipid complex assembly|phospholipase A2 activity|cellular biogenic amine metabolic process|sterol metabolic process|lipoprotein biosynthetic process|sterol transport|lipid homeostasis|response to corticosteroid|glycerophospholipid metabolic process|O-acyltransferase activity|response to glucocorticoid|phosphatidylcholine-sterol O-acyltransferase activity|cholesterol transport|cholesterol metabolic process|sterol homeostasis|reverse cholesterol transport|cholesterol homeostasis|cholesterol esterification K00650 lecithin-cholesterol acyltransferase[2.3.1.43] hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) 16:67939750-67944131 48 46 47 22 23 24 0.661215879923996 0.575894040046192 0.583732876594923 0.271531575294707 0.25995579765351 0.309847992077203 0.606947598855037 0.28044512167514 1.11385347836043 0.000443410756041522 0.00292091454343857 UP ENSG00000228549 RP11-108M9.3 - - - - - - - 1:16870945-16874092 18 25 22 5 11 8 0.219415887302407 0.276962429197761 0.241780181901423 0.0546048946972516 0.110012906545444 0.0913934998745729 0.24605283280053 0.0853371003724228 1.52772313042245 0.000443797486895295 0.00292281715724071 UP ENSG00000180638 SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2 [Source:HGNC Symbol;Acc:HGNC:26439] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0022857|GO:0071944|GO:0031224|GO:0005886|GO:0015238|GO:0006810|GO:0042493|GO:0055085|GO:0016021|GO:0006855|GO:0015893|GO:0015297 transporter activity|cell|membrane|cellular process|response to stimulus|transmembrane transporter activity|cell periphery|intrinsic component of membrane|plasma membrane|drug transmembrane transporter activity|transport|response to drug|transmembrane transport|integral component of membrane|drug transmembrane transport|drug transport|antiporter activity - - - - 17:19678288-19718979 6 6 16 26 26 44 0.0341158663737131 0.0310067373371718 0.0820296488703711 0.132462865720712 0.121302619160362 0.234479532184213 0.0490507508604187 0.162748339021762 -1.73029569334542 0.000445392131284337 0.00293267240568209 DOWN ENSG00000124208 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough [Source:HGNC Symbol;Acc:HGNC:33521] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 20:50081124-50153637 254 174 307 92 52 2 6.51693376175901 4.05730524546902 7.10169073280305 2.11492422386386 1.09467144167929 0.0480854155804992 5.89197658001036 1.08589369370788 2.43986882202503 0.000445981258278117 0.00293525822954426 UP ENSG00000157322 CLEC18A C-type lectin domain family 18 member A [Source:HGNC Symbol;Acc:HGNC:30388] GO:0005623|GO:0005576|GO:0005488|GO:0043229|GO:0030246|GO:0043227|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0043231|GO:0005737|GO:0005783|GO:0030247|GO:0005794|GO:0005768 cell|extracellular region|binding|intracellular organelle|carbohydrate binding|membrane-bounded organelle|extracellular space|intracellular|protein binding|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|polysaccharide binding|Golgi apparatus|endosome - - - - 16:69950705-69964452 0 0 1 8 3 8 0 0 0.00560294258766322 0.0445677086098864 0.0153055780437834 0.0466165491581389 0.00186764752922107 0.0354966119372696 -4.24838721555838 0.000447415915218838 0.00294275275015272 DOWN ENSG00000248202 RP11-455B3.1 - - - - - - - 5:97881420-97922695 0 0 0 4 3 6 0 0 0 0.261634066488482 0.179702333750386 0.410510824578648 0 0.283949074939172 -Inf 0.000447597375521448 0.00294329780810954 DOWN ENSG00000168899 VAMP5 vesicle associated membrane protein 5 [Source:HGNC Symbol;Acc:HGNC:12646] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0005488|GO:1903561|GO:0043229|GO:0009986|GO:0051641|GO:0005911|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0031090|GO:0009888|GO:0006810|GO:0007275|GO:0048513|GO:0044291|GO:0031982|GO:0061061|GO:0005887|GO:0043231|GO:0005737|GO:0012506|GO:0005484|GO:0045184|GO:0000149|GO:0031226|GO:0008104|GO:0061024|GO:0070062|GO:0051649|GO:0048869|GO:0016021|GO:0031301|GO:0010256|GO:0005768|GO:0006996|GO:0061025|GO:0016192|GO:0090150|GO:0016050|GO:0031410|GO:0015031|GO:0014704|GO:0007009|GO:0016023|GO:0060537|GO:0046907|GO:0005770|GO:0072657|GO:0048471|GO:0031988|GO:0034613|GO:0030659|GO:0030154|GO:0007517|GO:0048284|GO:0060538|GO:0072659|GO:0090002|GO:0048193|GO:0006886|GO:0006906|GO:0014706|GO:1990778|GO:0043001|GO:0007519|GO:0006892|GO:0006893 developmental process|cell|membrane|cellular process|extracellular region|cell junction|binding|extracellular vesicle|intracellular organelle|cell surface|cellular localization|cell-cell junction|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|organelle membrane|tissue development|transport|multicellular organism development|animal organ development|cell-cell contact zone|vesicle|muscle structure development|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|SNAP receptor activity|establishment of protein localization|SNARE binding|intrinsic component of plasma membrane|protein localization|membrane organization|extracellular exosome|establishment of localization in cell|cellular developmental process|integral component of membrane|integral component of organelle membrane|endomembrane system organization|endosome|organelle organization|membrane fusion|vesicle-mediated transport|establishment of protein localization to membrane|vesicle organization|cytoplasmic vesicle|protein transport|intercalated disc|plasma membrane organization|cytoplasmic, membrane-bounded vesicle|muscle tissue development|intracellular transport|late endosome|protein localization to membrane|perinuclear region of cytoplasm|membrane-bounded vesicle|cellular protein localization|cytoplasmic vesicle membrane|cell differentiation|muscle organ development|organelle fusion|skeletal muscle organ development|protein localization to plasma membrane|establishment of protein localization to plasma membrane|Golgi vesicle transport|intracellular protein transport|vesicle fusion|striated muscle tissue development|protein localization to cell periphery|Golgi to plasma membrane protein transport|skeletal muscle tissue development|post-Golgi vesicle-mediated transport|Golgi to plasma membrane transport K08514 vesicle-associated membrane protein 5[-] hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) 2:85584408-85593412 57 60 64 20 21 41 3.21786012802686 3.07840233419327 3.25751143741595 1.01161447240594 0.972709247510776 2.16924831942414 3.18459129987869 1.38452401311362 1.20171815760703 0.000456032293805902 0.00299020164710771 UP ENSG00000198513 ATL1 atlastin GTPase 1 [Source:HGNC Symbol;Acc:HGNC:11231] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0043229|GO:0042175|GO:0043167|GO:0009653|GO:0016043|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0042802|GO:0048468|GO:0007275|GO:0043168|GO:0001882|GO:0016817|GO:0022607|GO:0043231|GO:0005737|GO:0043005|GO:0005783|GO:0000166|GO:0030030|GO:0048869|GO:0016021|GO:0010256|GO:0005794|GO:0006996|GO:0000902|GO:0031175|GO:0035639|GO:0030424|GO:0001883|GO:0000904|GO:0016818|GO:0032549|GO:0006461|GO:0005795|GO:0032990|GO:0007399|GO:0007029|GO:0000139|GO:0017076|GO:0030154|GO:0048858|GO:0048666|GO:0030182|GO:0032561|GO:0051259|GO:0031985|GO:0061564|GO:0005525|GO:0022008|GO:0048667|GO:0048812|GO:0019001|GO:0016462|GO:0007409|GO:0048699|GO:0017111|GO:0051260|GO:0000137|GO:0003924 developmental process|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|anatomical structure development|organelle membrane|identical protein binding|cell development|multicellular organism development|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|neuron projection|endoplasmic reticulum|nucleotide binding|cell projection organization|cellular developmental process|integral component of membrane|endomembrane system organization|Golgi apparatus|organelle organization|cell morphogenesis|neuron projection development|purine ribonucleoside triphosphate binding|axon|purine nucleoside binding|cell morphogenesis involved in differentiation|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|protein complex assembly|Golgi stack|cell part morphogenesis|nervous system development|endoplasmic reticulum organization|Golgi membrane|purine nucleotide binding|cell differentiation|cell projection morphogenesis|neuron development|neuron differentiation|guanyl ribonucleotide binding|protein oligomerization|Golgi cisterna|axon development|GTP binding|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|guanyl nucleotide binding|pyrophosphatase activity|axonogenesis|generation of neurons|nucleoside-triphosphatase activity|protein homooligomerization|Golgi cis cisterna|GTPase activity - - - - 14:50532509-50633068 55 58 71 126 132 134 0.581976307333033 0.557765672488561 0.677358499511751 1.19457456329289 1.14600345912421 1.32885836179815 0.605700159777782 1.22314546140508 -1.013920288125 0.000456536613029845 0.00299219408241339 DOWN ENSG00000272142 RP11-428J1.5 - - - - - - - 6:5029972-5043449 9 3 7 21 25 24 0.299311329105752 0.0906875086483678 0.209879167748061 0.625747929307713 0.682153904452537 0.748034527182153 0.199959335167394 0.685312120314134 -1.77705456707185 0.000456524575418325 0.00299219408241339 DOWN ENSG00000118596 SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 [Source:HGNC Symbol;Acc:HGNC:10928] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0006810|GO:0005887|GO:0005737|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:1903825|GO:0006811|GO:0015129|GO:0015075|GO:0034220|GO:0006820|GO:0015711|GO:0005477|GO:0098656|GO:0015293|GO:0015727|GO:0008509|GO:0046942|GO:0046943|GO:1901475|GO:0015718|GO:0035873|GO:0008514|GO:0008028|GO:0035879|GO:0050833 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|transport|integral component of plasma membrane|cytoplasm|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|organic acid transmembrane transport|ion transport|lactate transmembrane transporter activity|ion transmembrane transporter activity|ion transmembrane transport|anion transport|organic anion transport|pyruvate secondary active transmembrane transporter activity|anion transmembrane transport|symporter activity|lactate transport|anion transmembrane transporter activity|carboxylic acid transport|carboxylic acid transmembrane transporter activity|pyruvate transmembrane transport|monocarboxylic acid transport|lactate transmembrane transport|organic anion transmembrane transporter activity|monocarboxylic acid transmembrane transporter activity|plasma membrane lactate transport|pyruvate transmembrane transporter activity - - - - 12:59596067-59789855 4 14 29 46 45 69 0.0155946784871664 0.049607133831614 0.101941803104659 0.160689576337447 0.143953091311587 0.252123715210592 0.0557145384744798 0.185588794286542 -1.73598385723295 0.000457273544351418 0.00299636619689799 DOWN ENSG00000260555 RP11-728K20.2 - - - - - - - 7:150000752-150005124 0 0 0 5 3 6 0 0 0 0.104097307466541 0.0572048493443246 0.130678380097474 0 0.0973268456361132 -Inf 0.000465749480306238 0.00305056713143099 DOWN ENSG00000215105 TTC3P1 tetratricopeptide repeat domain 3 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:23318] - - - - - - X:75740831-75746911 48 64 105 150 163 171 0.558352827398408 0.676597160509858 1.10122160644147 1.56336248971633 1.55570425946787 1.86421193793748 0.778723864783245 1.66109289570723 -1.09294901257186 0.000466988867588792 0.00305734334495522 DOWN ENSG00000116711 PLA2G4A phospholipase A2 group IVA [Source:HGNC Symbol;Acc:HGNC:9035] GO:0032502|GO:0000003|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0042698|GO:0019953|GO:0044237|GO:0003006|GO:0016043|GO:0051707|GO:0043227|GO:0008289|GO:0009607|GO:0009605|GO:0009893|GO:0032504|GO:0016787|GO:0009058|GO:0050793|GO:0005622|GO:0022602|GO:0005789|GO:0005515|GO:0012505|GO:0048856|GO:0031090|GO:0048609|GO:0019222|GO:0045137|GO:0001893|GO:0006575|GO:0008284|GO:0046697|GO:0042127|GO:0044255|GO:0050817|GO:0001890|GO:0001554|GO:0019866|GO:0009888|GO:0006810|GO:0051130|GO:0010941|GO:0006082|GO:0009991|GO:0007275|GO:0060627|GO:0048513|GO:0034641|GO:0043168|GO:0016788|GO:0044281|GO:0006952|GO:0005543|GO:0031982|GO:0019637|GO:0031325|GO:0051128|GO:0001542|GO:0010942|GO:0070169|GO:0030141|GO:0043231|GO:0048608|GO:0043169|GO:0019899|GO:0010243|GO:0031652|GO:0005737|GO:0006520|GO:0009611|GO:0009408|GO:0042592|GO:0001775|GO:0030728|GO:0007548|GO:0031966|GO:0060135|GO:0006979|GO:0048871|GO:0031340|GO:0009617|GO:0008406|GO:0045778|GO:0007565|GO:0061024|GO:0007276|GO:0006629|GO:0005783|GO:0030278|GO:0001503|GO:0042180|GO:0009725|GO:0008219|GO:0010035|GO:0044249|GO:0010876|GO:0009266|GO:0010033|GO:0031323|GO:0050878|GO:0005794|GO:0006996|GO:0007568|GO:0009636|GO:0007584|GO:0061025|GO:0016192|GO:0030501|GO:0005740|GO:0005829|GO:0006658|GO:0008654|GO:0030168|GO:0046486|GO:0046872|GO:0051597|GO:0016050|GO:0033993|GO:0008585|GO:0061458|GO:0031410|GO:0042542|GO:0050727|GO:0002237|GO:0016042|GO:0035035|GO:0048878|GO:0001894|GO:0007596|GO:0006066|GO:0044242|GO:0009308|GO:0006631|GO:0001659|GO:0046889|GO:0031214|GO:0046545|GO:0010038|GO:0016023|GO:0042060|GO:0042588|GO:0006811|GO:0006954|GO:0046470|GO:0033273|GO:0005743|GO:0007599|GO:0031620|GO:0097237|GO:0006869|GO:0050729|GO:0048471|GO:0031988|GO:0005739|GO:0010565|GO:0046677|GO:0005544|GO:0012501|GO:0014070|GO:0016298|GO:0000302|GO:0006796|GO:0033043|GO:0008610|GO:0031338|GO:0019216|GO:0046903|GO:0046890|GO:0031328|GO:0045923|GO:0043068|GO:0031622|GO:0031667|GO:0007292|GO:0046434|GO:0032496|GO:0005634|GO:0052689|GO:0030282|GO:0043067|GO:0006644|GO:0006690|GO:0048545|GO:0097305|GO:0046469|GO:0048284|GO:0030500|GO:0010638|GO:0019217|GO:0004620|GO:0033559|GO:0009395|GO:0036152|GO:0033280|GO:0004622|GO:0006820|GO:0015711|GO:0002673|GO:0006663|GO:0071236|GO:0043065|GO:0046474|GO:0010226|GO:0004623|GO:0051592|GO:0001676|GO:0002675|GO:0002526|GO:0015908|GO:0005509|GO:0046942|GO:0019369|GO:0006906|GO:0048875|GO:0006633|GO:0006576|GO:0042981|GO:0045723|GO:0036150|GO:0019752|GO:0036151|GO:0031649|GO:0046456|GO:0031960|GO:0046717|GO:0042304|GO:0006650|GO:0006915|GO:0006636|GO:0051384|GO:0015718|GO:0006654|GO:0047498|GO:0046488|GO:0046473|GO:0043129|GO:0001660|GO:0032787|GO:0006953|GO:0006693|GO:0015909|GO:0036149|GO:0050482|GO:0001516|GO:0031394|GO:0032048|GO:0036148|GO:0035965 developmental process|reproduction|cell|rhythmic process|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|ovulation cycle|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|cellular component organization|response to other organism|membrane-bounded organelle|lipid binding|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|hydrolase activity|biosynthetic process|regulation of developmental process|intracellular|ovulation cycle process|endoplasmic reticulum membrane|protein binding|endomembrane system|anatomical structure development|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|maternal placenta development|cellular modified amino acid metabolic process|positive regulation of cell proliferation|decidualization|regulation of cell proliferation|cellular lipid metabolic process|coagulation|placenta development|luteolysis|organelle inner membrane|tissue development|transport|positive regulation of cellular component organization|regulation of cell death|organic acid metabolic process|response to extracellular stimulus|multicellular organism development|regulation of vesicle-mediated transport|animal organ development|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|defense response|phospholipid binding|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|ovulation from ovarian follicle|positive regulation of cell death|positive regulation of biomineral tissue development|secretory granule|intracellular membrane-bounded organelle|reproductive structure development|cation binding|enzyme binding|response to organonitrogen compound|positive regulation of heat generation|cytoplasm|cellular amino acid metabolic process|response to wounding|response to heat|homeostatic process|cell activation|ovulation|sex differentiation|mitochondrial membrane|maternal process involved in female pregnancy|response to oxidative stress|multicellular organismal homeostasis|positive regulation of vesicle fusion|response to bacterium|gonad development|positive regulation of ossification|female pregnancy|membrane organization|gamete generation|lipid metabolic process|endoplasmic reticulum|regulation of ossification|ossification|cellular ketone metabolic process|response to hormone|cell death|response to inorganic substance|cellular biosynthetic process|lipid localization|response to temperature stimulus|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|Golgi apparatus|organelle organization|aging|response to toxic substance|response to nutrient|membrane fusion|vesicle-mediated transport|positive regulation of bone mineralization|mitochondrial envelope|cytosol|phosphatidylserine metabolic process|phospholipid biosynthetic process|platelet activation|glycerolipid metabolic process|metal ion binding|response to methylmercury|vesicle organization|response to lipid|female gonad development|reproductive system development|cytoplasmic vesicle|response to hydrogen peroxide|regulation of inflammatory response|response to molecule of bacterial origin|lipid catabolic process|histone acetyltransferase binding|chemical homeostasis|tissue homeostasis|blood coagulation|alcohol metabolic process|cellular lipid catabolic process|amine metabolic process|fatty acid metabolic process|temperature homeostasis|positive regulation of lipid biosynthetic process|biomineral tissue development|development of primary female sexual characteristics|response to metal ion|cytoplasmic, membrane-bounded vesicle|wound healing|zymogen granule|ion transport|inflammatory response|phosphatidylcholine metabolic process|response to vitamin|mitochondrial inner membrane|hemostasis|regulation of fever generation|cellular response to toxic substance|lipid transport|positive regulation of inflammatory response|perinuclear region of cytoplasm|membrane-bounded vesicle|mitochondrion|regulation of cellular ketone metabolic process|response to antibiotic|calcium-dependent phospholipid binding|programmed cell death|response to organic cyclic compound|lipase activity|response to reactive oxygen species|phosphate-containing compound metabolic process|regulation of organelle organization|lipid biosynthetic process|regulation of vesicle fusion|regulation of lipid metabolic process|secretion|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|positive regulation of fatty acid metabolic process|positive regulation of programmed cell death|positive regulation of fever generation|response to nutrient levels|female gamete generation|organophosphate catabolic process|response to lipopolysaccharide|nucleus|carboxylic ester hydrolase activity|bone mineralization|regulation of programmed cell death|phospholipid metabolic process|icosanoid metabolic process|response to steroid hormone|response to alcohol|platelet activating factor metabolic process|organelle fusion|regulation of bone mineralization|positive regulation of organelle organization|regulation of fatty acid metabolic process|phospholipase activity|unsaturated fatty acid metabolic process|phospholipid catabolic process|phosphatidylethanolamine acyl-chain remodeling|response to vitamin D|lysophospholipase activity|anion transport|organic anion transport|regulation of acute inflammatory response|platelet activating factor biosynthetic process|cellular response to antibiotic|positive regulation of apoptotic process|glycerophospholipid biosynthetic process|response to lithium ion|phospholipase A2 activity|response to calcium ion|long-chain fatty acid metabolic process|positive regulation of acute inflammatory response|acute inflammatory response|fatty acid transport|calcium ion binding|carboxylic acid transport|arachidonic acid metabolic process|vesicle fusion|chemical homeostasis within a tissue|fatty acid biosynthetic process|cellular biogenic amine metabolic process|regulation of apoptotic process|positive regulation of fatty acid biosynthetic process|phosphatidylserine acyl-chain remodeling|carboxylic acid metabolic process|phosphatidylcholine acyl-chain remodeling|heat generation|icosanoid biosynthetic process|response to corticosteroid|acid secretion|regulation of fatty acid biosynthetic process|glycerophospholipid metabolic process|apoptotic process|unsaturated fatty acid biosynthetic process|response to glucocorticoid|monocarboxylic acid transport|phosphatidic acid biosynthetic process|calcium-dependent phospholipase A2 activity|phosphatidylinositol metabolic process|phosphatidic acid metabolic process|surfactant homeostasis|fever generation|monocarboxylic acid metabolic process|acute-phase response|prostaglandin metabolic process|long-chain fatty acid transport|phosphatidylinositol acyl-chain remodeling|arachidonic acid secretion|prostaglandin biosynthetic process|positive regulation of prostaglandin biosynthetic process|cardiolipin metabolic process|phosphatidylglycerol acyl-chain remodeling|cardiolipin acyl-chain remodeling K16342 cytosolic phospholipase A2[3.1.1.4] hsa01100|hsa04010|hsa04014|hsa04921|hsa04072|hsa04611|hsa04270|hsa04724|hsa04726|hsa05231|hsa04750|hsa00564|hsa04666|hsa04912|hsa04664|hsa00590|hsa04370|hsa04730|hsa04913|hsa00565|hsa00591|hsa00592 Metabolic pathways - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Fc epsilon RI signaling pathway - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human)|VEGF signaling pathway - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|Ovarian steroidogenesis - Homo sapiens (human)|Ether lipid metabolism - Homo sapiens (human)|Linoleic acid metabolism - Homo sapiens (human)|alpha-Linolenic acid metabolism - Homo sapiens (human) 1:186828953-186988981 8 8 29 40 46 61 0.196823827334024 0.178886405785237 0.643314829122721 0.881798256021337 0.928607318922277 1.40658229053691 0.339675020747327 1.07232928849351 -1.65852096007403 0.000467691007864847 0.00306126887717543 DOWN ENSG00000124126 PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [Source:HGNC Symbol;Acc:HGNC:32594] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0045321|GO:0043229|GO:0050900|GO:0043167|GO:0044237|GO:0048870|GO:0023051|GO:0009653|GO:0016043|GO:0030427|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0009893|GO:0030234|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0005085|GO:0048856|GO:0019222|GO:0016337|GO:0043198|GO:0006935|GO:0045595|GO:0048468|GO:0051130|GO:0034446|GO:0007275|GO:0048513|GO:0070489|GO:0032535|GO:0016358|GO:0043168|GO:0008047|GO:0030155|GO:0005543|GO:0051128|GO:0030426|GO:0022607|GO:0098609|GO:0045597|GO:0043231|GO:0019899|GO:0005737|GO:0032970|GO:0005088|GO:0006928|GO:0072593|GO:0001775|GO:0043005|GO:0031589|GO:0009966|GO:0036477|GO:0010646|GO:0043085|GO:0046649|GO:0007154|GO:0016477|GO:0007165|GO:0045785|GO:0030595|GO:0050790|GO:0030030|GO:0048869|GO:0030029|GO:0043254|GO:0006996|GO:0000902|GO:0005829|GO:0031175|GO:0007186|GO:0031344|GO:0005096|GO:0032956|GO:1900026|GO:0007010|GO:0030097|GO:0050773|GO:0030098|GO:0051345|GO:0010720|GO:0030695|GO:0000904|GO:0060326|GO:0030425|GO:0007159|GO:0010810|GO:0048471|GO:0022604|GO:0006461|GO:0030036|GO:0042110|GO:0035556|GO:0033043|GO:1900024|GO:0007399|GO:0010770|GO:0010811|GO:0030154|GO:0030832|GO:0005089|GO:1902531|GO:0051960|GO:0006801|GO:0071621|GO:0048666|GO:0030182|GO:0002521|GO:0010975|GO:0042119|GO:1990266|GO:0034622|GO:0010769|GO:0030217|GO:0043623|GO:0043087|GO:0030593|GO:0070486|GO:0008064|GO:0043547|GO:0051493|GO:0051056|GO:0022008|GO:0007264|GO:0007015|GO:0050767|GO:0030833|GO:0051258|GO:0007265|GO:0046578|GO:0048699|GO:0071593|GO:0045664|GO:0008154|GO:0035023|GO:0007266|GO:0030041 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|leukocyte activation|intracellular organelle|leukocyte migration|ion binding|cellular metabolic process|cell motility|regulation of signaling|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|intracellular|immune system development|protein binding|plasma membrane|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|single organismal cell-cell adhesion|dendritic shaft|chemotaxis|regulation of cell differentiation|cell development|positive regulation of cellular component organization|substrate adhesion-dependent cell spreading|multicellular organism development|animal organ development|T cell aggregation|regulation of cellular component size|dendrite development|anion binding|enzyme activator activity|regulation of cell adhesion|phospholipid binding|regulation of cellular component organization|growth cone|cellular component assembly|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of actin filament-based process|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|reactive oxygen species metabolic process|cell activation|neuron projection|cell-substrate adhesion|regulation of signal transduction|somatodendritic compartment|regulation of cell communication|positive regulation of catalytic activity|lymphocyte activation|cell communication|cell migration|signal transduction|positive regulation of cell adhesion|leukocyte chemotaxis|regulation of catalytic activity|cell projection organization|cellular developmental process|actin filament-based process|regulation of protein complex assembly|organelle organization|cell morphogenesis|cytosol|neuron projection development|G-protein coupled receptor signaling pathway|regulation of cell projection organization|GTPase activator activity|regulation of actin cytoskeleton organization|positive regulation of substrate adhesion-dependent cell spreading|cytoskeleton organization|hemopoiesis|regulation of dendrite development|lymphocyte differentiation|positive regulation of hydrolase activity|positive regulation of cell development|GTPase regulator activity|cell morphogenesis involved in differentiation|cell chemotaxis|dendrite|leukocyte cell-cell adhesion|regulation of cell-substrate adhesion|perinuclear region of cytoplasm|regulation of cell morphogenesis|protein complex assembly|actin cytoskeleton organization|T cell activation|intracellular signal transduction|regulation of organelle organization|regulation of substrate adhesion-dependent cell spreading|nervous system development|positive regulation of cell morphogenesis involved in differentiation|positive regulation of cell-substrate adhesion|cell differentiation|regulation of actin filament length|Rho guanyl-nucleotide exchange factor activity|regulation of intracellular signal transduction|regulation of nervous system development|superoxide metabolic process|granulocyte chemotaxis|neuron development|neuron differentiation|leukocyte differentiation|regulation of neuron projection development|neutrophil activation|neutrophil migration|cellular macromolecular complex assembly|regulation of cell morphogenesis involved in differentiation|T cell differentiation|cellular protein complex assembly|regulation of GTPase activity|neutrophil chemotaxis|leukocyte aggregation|regulation of actin polymerization or depolymerization|positive regulation of GTPase activity|regulation of cytoskeleton organization|regulation of small GTPase mediated signal transduction|neurogenesis|small GTPase mediated signal transduction|actin filament organization|regulation of neurogenesis|regulation of actin filament polymerization|protein polymerization|Ras protein signal transduction|regulation of Ras protein signal transduction|generation of neurons|lymphocyte aggregation|regulation of neuron differentiation|actin polymerization or depolymerization|regulation of Rho protein signal transduction|Rho protein signal transduction|actin filament polymerization K12365 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger 1 protein[-] hsa04062 Chemokine signaling pathway - Homo sapiens (human) 20:48624252-48827883 21 23 38 57 62 94 0.187398033724588 0.186531900148413 0.305727163809938 0.455735135772866 0.453936020412344 0.786127885676791 0.226552365894313 0.565266347287334 -1.31908625272592 0.000468116663567954 0.00306276240222719 DOWN ENSG00000228638 FCF1P2 FCF1 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:44614] - - - - - - 3:48290793-48291375 68 111 59 36 43 35 8.25056786161564 12.2400016388243 6.45421088383446 3.91363048993826 4.28064233361479 3.97990249609218 8.9815934614248 4.05805843988174 1.14618178071507 0.000468124366629686 0.00306276240222719 UP ENSG00000160182 TFF1 trefoil factor 1 [Source:HGNC Symbol;Acc:HGNC:11755] GO:0032502|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0071704|GO:0005615|GO:0005515|GO:0042127|GO:0005102|GO:0010243|GO:0035902|GO:0005975|GO:0042592|GO:0048871|GO:0007586|GO:0009725|GO:0008285|GO:0048869|GO:0010035|GO:0010033|GO:0030277|GO:0001894|GO:1901652|GO:0010038|GO:0043434|GO:0010039|GO:0030154|GO:0008083|GO:0010669 developmental process|cellular process|extracellular region|metabolic process|response to stimulus|binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|organic substance metabolic process|extracellular space|protein binding|regulation of cell proliferation|receptor binding|response to organonitrogen compound|response to immobilization stress|carbohydrate metabolic process|homeostatic process|multicellular organismal homeostasis|digestion|response to hormone|negative regulation of cell proliferation|cellular developmental process|response to inorganic substance|response to organic substance|maintenance of gastrointestinal epithelium|tissue homeostasis|response to peptide|response to metal ion|response to peptide hormone|response to iron ion|cell differentiation|growth factor activity|epithelial structure maintenance - - - - 21:42362282-42366594 98 87 100 50 63 24 12.5811623841464 10.1506818612285 11.5747217839635 5.75120579658375 6.63596018401634 2.88760333814236 11.4355220097795 5.09158977291415 1.16733413178393 0.000472598217859654 0.00309000157599258 UP ENSG00000196466 ZNF799 zinc finger protein 799 [Source:HGNC Symbol;Acc:HGNC:28071] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:12390016-12401271 43 59 51 21 28 26 0.557906980767304 0.695704557469363 0.596584836629087 0.244124329720746 0.298069133561018 0.316148373087285 0.616732124955251 0.28611394545635 1.10805417914938 0.000474443093796414 0.00310002716616287 UP ENSG00000184619 KRBA2 KRAB-A domain containing 2 [Source:HGNC Symbol;Acc:HGNC:26989] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0006259|GO:0010467|GO:0009059|GO:0016070|GO:0015074|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|DNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|DNA integration|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 17:8368637-8376711 8 18 20 58 30 54 0.125026182851374 0.255671992360418 0.28182965972918 0.812187630307628 0.384697580643933 0.790953016106758 0.220842611646991 0.662612742352773 -1.5851473799773 0.000477426763619724 0.00311747563453702 DOWN ENSG00000227802 DNAJB3 DnaJ heat shock protein family (Hsp40) member B3 [Source:HGNC Symbol;Acc:HGNC:32397] - - - - - - 2:233742750-233744015 2 4 6 16 23 13 0.0709108400482858 0.128896846273824 0.19181369021568 0.508285475437248 0.669109283684598 0.432007881409092 0.13054045884593 0.536467546843646 -2.03899388353473 0.000478892359247775 0.0031256782888026 DOWN ENSG00000122122 SASH3 SAM and SH3 domain containing 3 [Source:HGNC Symbol;Acc:HGNC:15975] GO:0032502|GO:0040007|GO:0002376|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006955|GO:0045927|GO:0007155|GO:0043227|GO:0040008|GO:0002684|GO:0050793|GO:0048589|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0008284|GO:0042127|GO:0002250|GO:1903706|GO:0016337|GO:0045595|GO:0070661|GO:0050867|GO:0007275|GO:0048513|GO:0070489|GO:0046620|GO:0030155|GO:0001817|GO:0035265|GO:0098609|GO:0045597|GO:0043231|GO:0005737|GO:0001816|GO:0002377|GO:0042592|GO:0002696|GO:0001775|GO:0002367|GO:0048639|GO:0048871|GO:0001819|GO:0050776|GO:0046649|GO:0050865|GO:0046622|GO:0050778|GO:0048638|GO:0045785|GO:0048869|GO:0002443|GO:0002369|GO:0051249|GO:0042113|GO:0032943|GO:0030097|GO:0032613|GO:0030098|GO:0032623|GO:0001894|GO:0034109|GO:0032633|GO:0032753|GO:0002718|GO:0032673|GO:0048872|GO:0051251|GO:0002720|GO:0032743|GO:0022407|GO:0032733|GO:0007159|GO:0002821|GO:0002460|GO:0042110|GO:0002639|GO:0032609|GO:0002819|GO:0002637|GO:0046651|GO:0030154|GO:0022409|GO:0032729|GO:0005634|GO:0032649|GO:0032680|GO:0002521|GO:0042098|GO:0002456|GO:0050863|GO:0002726|GO:0048873|GO:0030217|GO:0045619|GO:0034112|GO:0050871|GO:0032640|GO:0070486|GO:0046631|GO:0050864|GO:0002724|GO:0042100|GO:0032760|GO:0050870|GO:0045621|GO:0050671|GO:1903039|GO:0032946|GO:0045582|GO:0030890|GO:0002711|GO:0046632|GO:0045580|GO:0030888|GO:0042129|GO:0035710|GO:0071593|GO:0042102|GO:0046638|GO:0043367|GO:2000516|GO:0043372|GO:0043370 developmental process|growth|immune system process|cell|cellular process|response to stimulus|binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|immune response|positive regulation of growth|cell adhesion|membrane-bounded organelle|regulation of growth|positive regulation of immune system process|regulation of developmental process|developmental growth|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|positive regulation of cell proliferation|regulation of cell proliferation|adaptive immune response|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of cell differentiation|leukocyte proliferation|positive regulation of cell activation|multicellular organism development|animal organ development|T cell aggregation|regulation of organ growth|regulation of cell adhesion|regulation of cytokine production|organ growth|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|cytokine production|immunoglobulin production|homeostatic process|positive regulation of leukocyte activation|cell activation|cytokine production involved in immune response|positive regulation of developmental growth|multicellular organismal homeostasis|positive regulation of cytokine production|regulation of immune response|lymphocyte activation|regulation of cell activation|positive regulation of organ growth|positive regulation of immune response|regulation of developmental growth|positive regulation of cell adhesion|cellular developmental process|leukocyte mediated immunity|T cell cytokine production|regulation of lymphocyte activation|B cell activation|mononuclear cell proliferation|hemopoiesis|interleukin-10 production|lymphocyte differentiation|interleukin-2 production|tissue homeostasis|homotypic cell-cell adhesion|interleukin-4 production|positive regulation of interleukin-4 production|regulation of cytokine production involved in immune response|regulation of interleukin-4 production|homeostasis of number of cells|positive regulation of lymphocyte activation|positive regulation of cytokine production involved in immune response|positive regulation of interleukin-2 production|regulation of cell-cell adhesion|positive regulation of interleukin-10 production|leukocyte cell-cell adhesion|positive regulation of adaptive immune response|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|T cell activation|positive regulation of immunoglobulin production|interferon-gamma production|regulation of adaptive immune response|regulation of immunoglobulin production|lymphocyte proliferation|cell differentiation|positive regulation of cell-cell adhesion|positive regulation of interferon-gamma production|nucleus|regulation of interferon-gamma production|regulation of tumor necrosis factor production|leukocyte differentiation|T cell proliferation|T cell mediated immunity|regulation of T cell activation|positive regulation of T cell cytokine production|homeostasis of number of cells within a tissue|T cell differentiation|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|positive regulation of B cell activation|tumor necrosis factor production|leukocyte aggregation|alpha-beta T cell activation|regulation of B cell activation|regulation of T cell cytokine production|B cell proliferation|positive regulation of tumor necrosis factor production|positive regulation of T cell activation|positive regulation of lymphocyte differentiation|positive regulation of lymphocyte proliferation|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|positive regulation of T cell differentiation|positive regulation of B cell proliferation|positive regulation of T cell mediated immunity|alpha-beta T cell differentiation|regulation of T cell differentiation|regulation of B cell proliferation|regulation of T cell proliferation|CD4-positive, alpha-beta T cell activation|lymphocyte aggregation|positive regulation of T cell proliferation|positive regulation of alpha-beta T cell differentiation|CD4-positive, alpha-beta T cell differentiation|positive regulation of CD4-positive, alpha-beta T cell activation|positive regulation of CD4-positive, alpha-beta T cell differentiation|regulation of CD4-positive, alpha-beta T cell differentiation - - - - X:129779979-129795201 9 7 10 0 0 4 0.213779448290106 0.151122074953444 0.214164042970831 0 0 0.0890339091708772 0.193021855404794 0.0296779697236257 2.70129990429917 0.000479636905770158 0.00312985359231963 UP ENSG00000132746 ALDH3B2 aldehyde dehydrogenase 3 family member B2 [Source:HGNC Symbol;Acc:HGNC:411] GO:0008152|GO:0003824|GO:0016491|GO:0071704|GO:0009056|GO:0044281|GO:0016903|GO:0006629|GO:0055114|GO:0006066|GO:0016620|GO:0004029|GO:0046164|GO:0004028|GO:0004030|GO:0006067|GO:0006068 metabolic process|catalytic activity|oxidoreductase activity|organic substance metabolic process|catabolic process|small molecule metabolic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors|lipid metabolic process|oxidation-reduction process|alcohol metabolic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|aldehyde dehydrogenase (NAD) activity|alcohol catabolic process|3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase [NAD(P)+] activity|ethanol metabolic process|ethanol catabolic process K00129 aldehyde dehydrogenase (NAD(P)+)[1.2.1.5] hsa01100|hsa05204|hsa00980|hsa00982|hsa00010|hsa00350|hsa00410|hsa00340|hsa00360 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human)|Tyrosine metabolism - Homo sapiens (human)|beta-Alanine metabolism - Homo sapiens (human)|Histidine metabolism - Homo sapiens (human)|Phenylalanine metabolism - Homo sapiens (human) 11:67662162-67681200 108 99 105 194 190 456 1.36201749030956 1.13468948662609 1.19388992490115 2.19210210312955 1.96599167238624 5.38957172343754 1.23019896727893 3.18255516631778 -1.37129385202834 0.000483055003113823 0.00314926748865762 DOWN ENSG00000183066 WBP2NL WBP2 N-terminal like [Source:HGNC Symbol;Acc:HGNC:28389] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0043229|GO:0044702|GO:0051321|GO:0019953|GO:0035039|GO:0016043|GO:0005622|GO:0005515|GO:0007049|GO:0007343|GO:0022607|GO:0005737|GO:0001775|GO:0019904|GO:0009566|GO:0006996|GO:0050699|GO:0007338|GO:0048471|GO:0070925|GO:0006997|GO:0005856|GO:0033011 reproduction|cell|cellular process|reproductive process|binding|intracellular organelle|single organism reproductive process|meiotic cell cycle|sexual reproduction|male pronucleus assembly|cellular component organization|intracellular|protein binding|cell cycle|egg activation|cellular component assembly|cytoplasm|cell activation|protein domain specific binding|fertilization|organelle organization|WW domain binding|single fertilization|perinuclear region of cytoplasm|organelle assembly|nucleus organization|cytoskeleton|perinuclear theca - - - - 22:41998725-42058456 17 12 35 52 49 104 0.145387945906572 0.0932713849533108 0.269882534845618 0.398461624849633 0.343837214763109 0.833582846123504 0.169513955235167 0.525293895245415 -1.63172077005817 0.000483885126594814 0.00315343954799423 DOWN ENSG00000204657 OR2H2 olfactory receptor family 2 subfamily H member 2 [Source:HGNC Symbol;Acc:HGNC:8253] GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0050896|GO:0051716|GO:0004872|GO:0051606|GO:0050794|GO:0006950|GO:0019953|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0007618|GO:0050877|GO:0006952|GO:0004888|GO:0050906|GO:0007154|GO:0009593|GO:0007165|GO:0016021|GO:0007186|GO:0050907|GO:0007600|GO:0004984|GO:0004930|GO:0050911|GO:0007606|GO:0007608 signal transducer activity|reproduction|signaling|cell|membrane|cellular process|reproductive process|response to stimulus|cellular response to stimulus|receptor activity|detection of stimulus|regulation of cellular process|response to stress|sexual reproduction|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|mating|neurological system process|defense response|transmembrane signaling receptor activity|detection of stimulus involved in sensory perception|cell communication|detection of chemical stimulus|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|detection of chemical stimulus involved in sensory perception|sensory perception|olfactory receptor activity|G-protein coupled receptor activity|detection of chemical stimulus involved in sensory perception of smell|sensory perception of chemical stimulus|sensory perception of smell - - - - 6:29587455-29589038 5 3 8 0 1 0 0.223296051272269 0.121775461423661 0.322111373720775 0 0.0366560780204245 0 0.222394295472235 0.0122186926734748 4.18595794382196 0.000485322581058721 0.00316004805560023 UP ENSG00000268173 AC007192.4 - GO:0023052|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0005515|GO:0007154|GO:0007165 signaling|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|protein binding|cell communication|signal transduction - - - - 19:18153158-18178117 50 22 385 1 0 26 0.68782782366901 0.275052634332853 4.77516839933376 0.0123198742708697 0 0.335208271114717 1.91268295244521 0.115842715128529 4.04535852442947 0.000486248410913562 0.0031647642078756 UP ENSG00000257950 P2RX5-TAX1BP3 P2RX5-TAX1BP3 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:49191] GO:0004871|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0004872|GO:0022857|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0005887|GO:0010243|GO:0004888|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0010033|GO:0014074|GO:0046683|GO:0015267|GO:0006811|GO:0015075|GO:0033198|GO:0014070|GO:0034220|GO:0015276|GO:0098655|GO:0005216|GO:0006812|GO:0001614|GO:0008324|GO:0005230|GO:0005261|GO:0004931|GO:0005231 signal transducer activity|transporter activity|cell|membrane|cellular process|response to stimulus|receptor activity|transmembrane transporter activity|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|transport|integral component of plasma membrane|response to organonitrogen compound|transmembrane signaling receptor activity|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|response to organic substance|response to purine-containing compound|response to organophosphorus|channel activity|ion transport|ion transmembrane transporter activity|response to ATP|response to organic cyclic compound|ion transmembrane transport|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|cation transport|purinergic nucleotide receptor activity|cation transmembrane transporter activity|extracellular ligand-gated ion channel activity|cation channel activity|extracellular ATP-gated cation channel activity|excitatory extracellular ligand-gated ion channel activity - - - - 17:3663063-3696194 50 224 49 41 30 20 0.598951849162752 2.43867157759722 0.529216668130119 0.440053984684531 0.294858806095587 0.224531065377674 1.1889466982967 0.319814618719264 1.89437624803378 0.000487228489171704 0.00316831176557004 UP ENSG00000265413 RP11-789C17.1 - - - - - - - 18:8402847-8405161 0 0 1 5 3 14 0 0 0.0275354979783345 0.136877841869612 0.0752188170212199 0.400925040513545 0.0091784993261115 0.204340566468126 -4.47657353762702 0.000488993128975454 0.00317632743090366 DOWN ENSG00000183775 KCTD16 potassium channel tetramerization domain containing 16 [Source:HGNC Symbol;Acc:HGNC:29244] GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0023051|GO:0016043|GO:0071944|GO:0005515|GO:0005886|GO:0043234|GO:0097060|GO:0045211|GO:0022607|GO:0042734|GO:0043235|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0007186|GO:0008277|GO:0006461|GO:0051259|GO:0051260 macromolecular complex|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|regulation of signaling|cellular component organization|cell periphery|protein binding|plasma membrane|protein complex|synaptic membrane|postsynaptic membrane|cellular component assembly|presynaptic membrane|receptor complex|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|protein complex assembly|protein oligomerization|protein homooligomerization - - - - 5:144170832-144485686 0 1 3 15 10 5 0 0.00425804215405093 0.0126647323279226 0.0629381482950346 0.0384243489207409 0.0219463252988409 0.00564092482732451 0.0411029408382055 -2.86523800332815 0.000491369612294751 0.00319037590375109 DOWN ENSG00000218416 PP14571 uncharacterized LOC100130449 [Source:EntrezGene;Acc:100130449] - - - - - - 2:240449315-240456714 20 14 19 37 48 71 0.229665181803928 0.146107504725158 0.196712599636475 0.38068106641799 0.452242593461253 0.764099359711234 0.190828428721854 0.532341006530159 -1.48007458888588 0.000492774684861953 0.00319880309673162 DOWN ENSG00000138798 EGF epidermal growth factor [Source:HGNC Symbol;Acc:HGNC:3229] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0051051|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0009653|GO:0030297|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0030234|GO:0050793|GO:0005622|GO:0002682|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0048514|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0050817|GO:0006935|GO:0045087|GO:0035239|GO:0006725|GO:0009888|GO:0048468|GO:0032369|GO:0006810|GO:0022402|GO:0035295|GO:0051130|GO:1901360|GO:0001568|GO:0007275|GO:0048513|GO:0051302|GO:0005102|GO:0034641|GO:0008047|GO:0032940|GO:0030902|GO:0006952|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0022607|GO:0051098|GO:0030141|GO:0043231|GO:0043169|GO:0010243|GO:0004888|GO:0005774|GO:0005737|GO:0007389|GO:0001763|GO:0061377|GO:0009611|GO:0060322|GO:0032880|GO:0043235|GO:0005975|GO:0051222|GO:0006928|GO:0001775|GO:0060749|GO:0009966|GO:0048729|GO:0045184|GO:0045787|GO:0032388|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0001525|GO:1900182|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0009968|GO:0070062|GO:0051649|GO:0061351|GO:0009725|GO:0017147|GO:0090316|GO:0030546|GO:0050790|GO:0051048|GO:0030030|GO:0031983|GO:0051781|GO:0051301|GO:0019207|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0010876|GO:0010469|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0048732|GO:0050878|GO:0006996|GO:0071774|GO:0021534|GO:0000165|GO:0016192|GO:1902533|GO:0032268|GO:0000902|GO:0042307|GO:0006109|GO:0045732|GO:0031175|GO:0005976|GO:0030879|GO:0010468|GO:0034645|GO:0030168|GO:0090068|GO:0051101|GO:0046872|GO:0007166|GO:0002009|GO:0070851|GO:1903047|GO:0001944|GO:0043412|GO:0072594|GO:0007176|GO:0072358|GO:0030163|GO:0007417|GO:0031410|GO:0019887|GO:0009798|GO:0007596|GO:0051252|GO:0032386|GO:0048754|GO:0051223|GO:0015031|GO:0044265|GO:1901652|GO:0061138|GO:0000904|GO:0005773|GO:0071417|GO:0010628|GO:0016023|GO:0006887|GO:0051347|GO:0036211|GO:0000278|GO:0070201|GO:0042060|GO:0046907|GO:0006811|GO:0003002|GO:0051046|GO:1901184|GO:0032368|GO:0007346|GO:0043434|GO:0007599|GO:0006869|GO:0044344|GO:0010564|GO:0051099|GO:0051247|GO:0070848|GO:0006508|GO:0031988|GO:0034765|GO:0006259|GO:1901185|GO:0002764|GO:0006461|GO:1904591|GO:0043269|GO:0034613|GO:0032270|GO:0060429|GO:0006796|GO:0035556|GO:0060205|GO:1901137|GO:0033043|GO:0044267|GO:0051174|GO:0042176|GO:0007067|GO:0010467|GO:0017038|GO:0032990|GO:0019209|GO:2000179|GO:0007399|GO:0060562|GO:0046903|GO:0071310|GO:0097485|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0034774|GO:0048858|GO:0021940|GO:1903827|GO:1902531|GO:2000177|GO:0016070|GO:0045931|GO:0008083|GO:0072359|GO:0031091|GO:0032870|GO:1901186|GO:0010557|GO:0016051|GO:1900127|GO:0006606|GO:0051960|GO:2000273|GO:0034220|GO:0042813|GO:0010638|GO:0048666|GO:0030182|GO:0032375|GO:0007411|GO:0016055|GO:1904589|GO:0044257|GO:2000008|GO:0045893|GO:0033365|GO:0033157|GO:0045055|GO:0031401|GO:0006260|GO:0008543|GO:0045742|GO:0034622|GO:0051169|GO:1901653|GO:0043408|GO:0000323|GO:0000271|GO:0005154|GO:0042058|GO:0007088|GO:0032774|GO:1903364|GO:0030162|GO:0006812|GO:2001141|GO:0021936|GO:0043623|GO:0045862|GO:0071363|GO:0016310|GO:0045741|GO:0006605|GO:0002768|GO:0038179|GO:0070371|GO:0043388|GO:0005509|GO:0034394|GO:0061564|GO:0016482|GO:0006886|GO:0048017|GO:0051603|GO:0007167|GO:0042059|GO:0030295|GO:0071375|GO:0009953|GO:0043410|GO:0006024|GO:0015918|GO:0045840|GO:0032868|GO:0042306|GO:0030203|GO:1900180|GO:0022008|GO:0035413|GO:0009950|GO:0048667|GO:0007264|GO:0006464|GO:0031093|GO:0048812|GO:0007262|GO:0035411|GO:0043549|GO:0006351|GO:0005765|GO:0006355|GO:0090279|GO:0033674|GO:0046824|GO:0048011|GO:1903533|GO:0000186|GO:0090370|GO:0007259|GO:0007265|GO:0006913|GO:0045859|GO:1903052|GO:0048015|GO:0045860|GO:0043406|GO:0007409|GO:0005764|GO:0019941|GO:0006468|GO:0048699|GO:0035412|GO:1903506|GO:0032374|GO:0060070|GO:0043405|GO:0042325|GO:0030301|GO:0001932|GO:0044332|GO:0032869|GO:0018193|GO:0038093|GO:0030001|GO:0001934|GO:0051924|GO:0007171|GO:0002576|GO:0030296|GO:0021930|GO:0030213|GO:0042327|GO:0034504|GO:0046822|GO:0007169|GO:0032446|GO:0048010|GO:0050731|GO:0006511|GO:0051170|GO:0031398|GO:0050730|GO:0030212|GO:0061097|GO:2000058|GO:0000187|GO:0038095|GO:0031396|GO:0071902|GO:0033344|GO:2000060|GO:0010874|GO:0071900|GO:0018107|GO:0061098|GO:0032147|GO:0008286|GO:0038127|GO:0018108|GO:0010800|GO:0007173|GO:0042787|GO:0006816|GO:0016567|GO:0070509 locomotion|developmental process|macromolecular complex|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|ion binding|immune response|negative regulation of transport|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|anatomical structure morphogenesis|transmembrane receptor protein tyrosine kinase activator activity|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|enzyme regulator activity|regulation of developmental process|intracellular|regulation of immune system process|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|coagulation|chemotaxis|innate immune response|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|cell development|negative regulation of lipid transport|transport|cell cycle process|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|animal organ development|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|enzyme activator activity|secretion by cell|hindbrain development|defense response|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|cellular component assembly|regulation of binding|secretory granule|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|transmembrane signaling receptor activity|vacuolar membrane|cytoplasm|pattern specification process|morphogenesis of a branching structure|mammary gland lobule development|response to wounding|head development|regulation of protein localization|receptor complex|carbohydrate metabolic process|positive regulation of protein transport|movement of cell or subcellular component|cell activation|mammary gland alveolus development|regulation of signal transduction|tissue morphogenesis|establishment of protein localization|positive regulation of cell cycle|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|angiogenesis|positive regulation of protein localization to nucleus|protein localization|cell communication|transmembrane transport|signal transduction|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|neural precursor cell proliferation|response to hormone|Wnt-protein binding|positive regulation of intracellular protein transport|receptor activator activity|regulation of catalytic activity|negative regulation of secretion|cell projection organization|vesicle lumen|positive regulation of cell division|cell division|kinase regulator activity|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|regulation of receptor activity|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|gland development|regulation of body fluid levels|organelle organization|response to fibroblast growth factor|cell proliferation in hindbrain|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|positive regulation of protein import into nucleus|regulation of carbohydrate metabolic process|positive regulation of protein catabolic process|neuron projection development|polysaccharide metabolic process|mammary gland development|regulation of gene expression|cellular macromolecule biosynthetic process|platelet activation|positive regulation of cell cycle process|regulation of DNA binding|metal ion binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|growth factor receptor binding|mitotic cell cycle process|vasculature development|macromolecule modification|establishment of protein localization to organelle|regulation of epidermal growth factor-activated receptor activity|cardiovascular system development|protein catabolic process|central nervous system development|cytoplasmic vesicle|protein kinase regulator activity|axis specification|blood coagulation|regulation of RNA metabolic process|regulation of intracellular transport|branching morphogenesis of an epithelial tube|regulation of protein transport|protein transport|cellular macromolecule catabolic process|response to peptide|morphogenesis of a branching epithelium|cell morphogenesis involved in differentiation|vacuole|cellular response to organonitrogen compound|positive regulation of gene expression|cytoplasmic, membrane-bounded vesicle|exocytosis|positive regulation of transferase activity|protein modification process|mitotic cell cycle|regulation of establishment of protein localization|wound healing|intracellular transport|ion transport|regionalization|regulation of secretion|regulation of ERBB signaling pathway|regulation of lipid transport|regulation of mitotic cell cycle|response to peptide hormone|hemostasis|lipid transport|cellular response to fibroblast growth factor stimulus|regulation of cell cycle process|positive regulation of binding|positive regulation of protein metabolic process|response to growth factor|proteolysis|membrane-bounded vesicle|regulation of ion transmembrane transport|DNA metabolic process|negative regulation of ERBB signaling pathway|immune response-regulating signaling pathway|protein complex assembly|positive regulation of protein import|regulation of ion transport|cellular protein localization|positive regulation of cellular protein metabolic process|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic membrane-bounded vesicle lumen|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|mitotic nuclear division|gene expression|protein import|cell part morphogenesis|kinase activator activity|positive regulation of neural precursor cell proliferation|nervous system development|epithelial tube morphogenesis|secretion|cellular response to organic substance|neuron projection guidance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|secretory granule lumen|cell projection morphogenesis|positive regulation of cerebellar granule cell precursor proliferation|regulation of cellular protein localization|regulation of intracellular signal transduction|regulation of neural precursor cell proliferation|RNA metabolic process|positive regulation of mitotic cell cycle|growth factor activity|circulatory system development|platelet alpha granule|cellular response to hormone stimulus|positive regulation of ERBB signaling pathway|positive regulation of macromolecule biosynthetic process|carbohydrate biosynthetic process|positive regulation of hyaluronan biosynthetic process|protein import into nucleus|regulation of nervous system development|positive regulation of receptor activity|ion transmembrane transport|Wnt-activated receptor activity|positive regulation of organelle organization|neuron development|neuron differentiation|negative regulation of cholesterol transport|axon guidance|Wnt signaling pathway|regulation of protein import|cellular protein catabolic process|regulation of protein localization to cell surface|positive regulation of transcription, DNA-templated|protein localization to organelle|regulation of intracellular protein transport|regulated exocytosis|positive regulation of protein modification process|DNA replication|fibroblast growth factor receptor signaling pathway|positive regulation of epidermal growth factor receptor signaling pathway|cellular macromolecular complex assembly|nuclear transport|cellular response to peptide|regulation of MAPK cascade|lytic vacuole|polysaccharide biosynthetic process|epidermal growth factor receptor binding|regulation of epidermal growth factor receptor signaling pathway|regulation of mitotic nuclear division|RNA biosynthetic process|positive regulation of cellular protein catabolic process|regulation of proteolysis|cation transport|regulation of RNA biosynthetic process|regulation of cerebellar granule cell precursor proliferation|cellular protein complex assembly|positive regulation of proteolysis|cellular response to growth factor stimulus|phosphorylation|positive regulation of epidermal growth factor-activated receptor activity|protein targeting|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|ERK1 and ERK2 cascade|positive regulation of DNA binding|calcium ion binding|protein localization to cell surface|axon development|cytosolic transport|intracellular protein transport|inositol lipid-mediated signaling|proteolysis involved in cellular protein catabolic process|enzyme linked receptor protein signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein kinase activator activity|cellular response to peptide hormone stimulus|dorsal/ventral pattern formation|positive regulation of MAPK cascade|glycosaminoglycan biosynthetic process|sterol transport|positive regulation of mitotic nuclear division|response to insulin|regulation of protein import into nucleus|glycosaminoglycan metabolic process|regulation of protein localization to nucleus|neurogenesis|positive regulation of catenin import into nucleus|dorsal/ventral axis specification|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|platelet alpha granule lumen|neuron projection morphogenesis|STAT protein import into nucleus|catenin import into nucleus|regulation of kinase activity|transcription, DNA-templated|lysosomal membrane|regulation of transcription, DNA-templated|regulation of calcium ion import|positive regulation of kinase activity|positive regulation of nucleocytoplasmic transport|neurotrophin TRK receptor signaling pathway|regulation of protein targeting|activation of MAPKK activity|negative regulation of cholesterol efflux|JAK-STAT cascade|Ras protein signal transduction|nucleocytoplasmic transport|regulation of protein kinase activity|positive regulation of proteolysis involved in cellular protein catabolic process|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|axonogenesis|lysosome|modification-dependent protein catabolic process|protein phosphorylation|generation of neurons|regulation of catenin import into nucleus|regulation of nucleic acid-templated transcription|regulation of cholesterol transport|canonical Wnt signaling pathway|regulation of MAP kinase activity|regulation of phosphorylation|cholesterol transport|regulation of protein phosphorylation|Wnt signaling pathway involved in dorsal/ventral axis specification|cellular response to insulin stimulus|peptidyl-amino acid modification|Fc receptor signaling pathway|metal ion transport|positive regulation of protein phosphorylation|regulation of calcium ion transport|activation of transmembrane receptor protein tyrosine kinase activity|platelet degranulation|protein tyrosine kinase activator activity|cerebellar granule cell precursor proliferation|hyaluronan biosynthetic process|positive regulation of phosphorylation|protein localization to nucleus|regulation of nucleocytoplasmic transport|transmembrane receptor protein tyrosine kinase signaling pathway|protein modification by small protein conjugation|vascular endothelial growth factor receptor signaling pathway|positive regulation of peptidyl-tyrosine phosphorylation|ubiquitin-dependent protein catabolic process|nuclear import|positive regulation of protein ubiquitination|regulation of peptidyl-tyrosine phosphorylation|hyaluronan metabolic process|regulation of protein tyrosine kinase activity|regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|activation of MAPK activity|Fc-epsilon receptor signaling pathway|regulation of protein ubiquitination|positive regulation of protein serine/threonine kinase activity|cholesterol efflux|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cholesterol efflux|regulation of protein serine/threonine kinase activity|peptidyl-threonine phosphorylation|positive regulation of protein tyrosine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|peptidyl-tyrosine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|epidermal growth factor receptor signaling pathway|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|calcium ion transport|protein ubiquitination|calcium ion import K04357 epidermal growth factor[-] hsa05200|hsa04151|hsa04060|hsa04144|hsa04010|hsa04014|hsa04810|hsa04015|hsa04510|hsa04072|hsa04068|hsa05160|hsa04066|hsa05231|hsa05215|hsa04540|hsa04012|hsa05218|hsa05212|hsa05214|hsa05223|hsa05213|hsa05219 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Endocytosis - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|FoxO signaling pathway - Homo sapiens (human)|Hepatitis C - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human)|Prostate cancer - Homo sapiens (human)|Gap junction - Homo sapiens (human)|ErbB signaling pathway - Homo sapiens (human)|Melanoma - Homo sapiens (human)|Pancreatic cancer - Homo sapiens (human)|Glioma - Homo sapiens (human)|Non-small cell lung cancer - Homo sapiens (human)|Endometrial cancer - Homo sapiens (human)|Bladder cancer - Homo sapiens (human) 4:109912884-110012266 34 47 51 91 89 128 0.215875923358353 0.271208475215343 0.291946910448055 0.517676436000341 0.463640485032574 0.761658124010766 0.25967710300725 0.580991681681227 -1.16179869787696 0.000492961017119068 0.00319931700110275 DOWN ENSG00000254706 RP11-565P22.6 - - - - - - - 1:162365407-162383531 6 7 13 20 38 28 0.309556074171401 0.328257869592528 0.604727426535672 0.924546268362253 1.60865988812725 1.35391132080767 0.414180456766534 1.29570582576572 -1.64540682278988 0.000498175819522001 0.00323245836035858 DOWN ENSG00000160007 ARHGAP35 Rho GTPase activating protein 35 [Source:HGNC Symbol;Acc:HGNC:4591] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0023051|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0030234|GO:0050793|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0008360|GO:0006935|GO:0045595|GO:0035239|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:0051130|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043168|GO:0008047|GO:0030900|GO:0001882|GO:0046483|GO:0051128|GO:0007420|GO:0045597|GO:0043231|GO:0005737|GO:0000981|GO:0060322|GO:0007423|GO:0006928|GO:0021915|GO:0009966|GO:0048729|GO:0048598|GO:0009890|GO:0010646|GO:0006139|GO:0043085|GO:0007154|GO:0035148|GO:0007165|GO:0009968|GO:0043114|GO:0050790|GO:0000166|GO:0030030|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0003013|GO:0000902|GO:0005829|GO:0031175|GO:0003677|GO:0031344|GO:0010468|GO:0034645|GO:0003714|GO:0005096|GO:0001654|GO:0002009|GO:0035639|GO:0007417|GO:0051345|GO:0010629|GO:0010720|GO:0030695|GO:0051252|GO:0001883|GO:0031346|GO:0000904|GO:0009790|GO:0072175|GO:0032549|GO:0016331|GO:0050769|GO:0022604|GO:0001841|GO:0060429|GO:0035556|GO:0010467|GO:0032990|GO:0007399|GO:0060562|GO:0001227|GO:0097485|GO:1902532|GO:0017076|GO:0009059|GO:0030154|GO:0048858|GO:0060606|GO:1902531|GO:0016070|GO:0008015|GO:0005856|GO:0005634|GO:0051960|GO:0043116|GO:0048666|GO:0030182|GO:0015629|GO:0007411|GO:0000975|GO:0032561|GO:0010975|GO:0009792|GO:0001843|GO:0045892|GO:0043010|GO:0032774|GO:0043565|GO:2001141|GO:0001838|GO:0043087|GO:1902679|GO:0003690|GO:0061564|GO:0043547|GO:0005525|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0051058|GO:0050767|GO:0048812|GO:0019001|GO:0010976|GO:0006351|GO:0006355|GO:0045666|GO:0006366|GO:0007265|GO:0046578|GO:1903507|GO:0006357|GO:0007409|GO:0048699|GO:1903506|GO:0044212|GO:0043009|GO:0000122|GO:0045664|GO:0046580|GO:0035024|GO:0000976|GO:0001012|GO:0035023|GO:0007266|GO:0000977 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|regulation of developmental process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|regulation of cell shape|chemotaxis|regulation of cell differentiation|tube morphogenesis|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|tube development|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|enzyme activator activity|forebrain development|nucleoside binding|heterocycle metabolic process|regulation of cellular component organization|brain development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|sensory organ development|movement of cell or subcellular component|neural tube development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|cell communication|tube formation|signal transduction|negative regulation of signal transduction|regulation of vascular permeability|regulation of catalytic activity|nucleotide binding|cell projection organization|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|cell morphogenesis|cytosol|neuron projection development|DNA binding|regulation of cell projection organization|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|GTPase activator activity|eye development|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|central nervous system development|positive regulation of hydrolase activity|negative regulation of gene expression|positive regulation of cell development|GTPase regulator activity|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|embryo development|epithelial tube formation|ribonucleoside binding|morphogenesis of embryonic epithelium|positive regulation of neurogenesis|regulation of cell morphogenesis|neural tube formation|epithelium development|intracellular signal transduction|gene expression|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|neuron projection guidance|negative regulation of intracellular signal transduction|purine nucleotide binding|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|tube closure|regulation of intracellular signal transduction|RNA metabolic process|blood circulation|cytoskeleton|nucleus|regulation of nervous system development|negative regulation of vascular permeability|neuron development|neuron differentiation|actin cytoskeleton|axon guidance|regulatory region DNA binding|guanyl ribonucleotide binding|regulation of neuron projection development|embryo development ending in birth or egg hatching|neural tube closure|negative regulation of transcription, DNA-templated|camera-type eye development|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|embryonic epithelial tube formation|regulation of GTPase activity|negative regulation of RNA biosynthetic process|double-stranded DNA binding|axon development|positive regulation of GTPase activity|GTP binding|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|negative regulation of small GTPase mediated signal transduction|regulation of neurogenesis|neuron projection morphogenesis|guanyl nucleotide binding|positive regulation of neuron projection development|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of neuron differentiation|transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of Ras protein signal transduction|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|negative regulation of transcription from RNA polymerase II promoter|regulation of neuron differentiation|negative regulation of Ras protein signal transduction|negative regulation of Rho protein signal transduction|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|regulation of Rho protein signal transduction|Rho protein signal transduction|RNA polymerase II regulatory region sequence-specific DNA binding K05732 glucocorticoid receptor DNA-binding factor 1[-] hsa04810|hsa04510|hsa04611|hsa04670 Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human) 19:46918676-47005077 1033 1400 2772 3149 3501 4206 3.67635253392648 4.52819202099662 8.89455395947283 10.0412358877925 10.2229621923892 14.0286220508972 5.69969950479864 11.430940043693 -1.00398628529508 0.00049839500747299 0.00323247546232862 DOWN ENSG00000088280 ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [Source:HGNC Symbol;Acc:HGNC:14987] GO:0040011|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0042995|GO:0030055|GO:0050794|GO:0043167|GO:0048870|GO:0016043|GO:0009893|GO:0031252|GO:0030234|GO:0005622|GO:0005515|GO:0019222|GO:0008047|GO:0005924|GO:0005912|GO:0051128|GO:0022607|GO:0043169|GO:0005737|GO:0032970|GO:0001726|GO:0006928|GO:0032231|GO:0043085|GO:0016477|GO:0050790|GO:0030029|GO:0006996|GO:0051017|GO:0005096|GO:0046872|GO:0032956|GO:0007010|GO:0051345|GO:0030695|GO:0030036|GO:0033043|GO:0051492|GO:0005925|GO:0043087|GO:0043547|GO:0051493|GO:0031032|GO:0030038|GO:0007015|GO:0043149|GO:0061572 locomotion|cell|cellular process|metabolic process|cell junction|binding|cell projection|cell-substrate junction|regulation of cellular process|ion binding|cell motility|cellular component organization|positive regulation of metabolic process|cell leading edge|enzyme regulator activity|intracellular|protein binding|regulation of metabolic process|enzyme activator activity|cell-substrate adherens junction|adherens junction|regulation of cellular component organization|cellular component assembly|cation binding|cytoplasm|regulation of actin filament-based process|ruffle|movement of cell or subcellular component|regulation of actin filament bundle assembly|positive regulation of catalytic activity|cell migration|regulation of catalytic activity|actin filament-based process|organelle organization|actin filament bundle assembly|GTPase activator activity|metal ion binding|regulation of actin cytoskeleton organization|cytoskeleton organization|positive regulation of hydrolase activity|GTPase regulator activity|actin cytoskeleton organization|regulation of organelle organization|regulation of stress fiber assembly|focal adhesion|regulation of GTPase activity|positive regulation of GTPase activity|regulation of cytoskeleton organization|actomyosin structure organization|contractile actin filament bundle assembly|actin filament organization|stress fiber assembly|actin filament bundle organization - - - - 1:23428563-23484568 131 105 265 315 356 523 1.15817115890232 0.843669184221993 2.11232969814146 2.49522501311417 2.58237925929792 4.33343542945525 1.37139001375526 3.13701323395578 -1.19375269353943 0.000498526402349058 0.00323262537266047 DOWN ENSG00000251258 RFPL4B ret finger protein-like 4B [Source:HGNC Symbol;Acc:HGNC:33264] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|protein binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 6:112347330-112351296 0 9 9 29 23 20 0 0.304534812299734 0.302088996733449 0.967375087627465 0.702564747868828 0.697818916344824 0.202207936344394 0.789252917280372 -1.96464806624744 0.000498692158821372 0.00323299798250884 DOWN ENSG00000230834 AC068580.7 - - - - - - - 11:1776930-1778388 3 2 4 14 15 13 0.627910708044213 0.380398237154257 0.754769846114953 2.62524241566771 2.57573871500499 2.54986900417497 0.587692930437808 2.58361671161589 -2.13625760829347 0.000499080033546438 0.00323481010019439 DOWN ENSG00000268543 CTD-2619J13.16 - - - - - - - 19:58418560-58419310 22 36 28 10 9 15 3.14384776931016 4.67544015120505 3.60751254051362 1.28042126478454 1.0552253795221 2.00894386700318 3.80893348700961 1.44819683710327 1.39512939019803 0.000502169487602777 0.00325271596504519 UP ENSG00000183722 LHFP lipoma HMGIC fusion partner [Source:HGNC Symbol;Acc:HGNC:6586] GO:0016020|GO:0005488|GO:0097159|GO:0031224|GO:0003676|GO:0016021|GO:0003677 membrane|binding|organic cyclic compound binding|intrinsic component of membrane|nucleic acid binding|integral component of membrane|DNA binding - - - - 13:39342892-39603528 0 0 5 12 13 8 0 0 0.124748390378208 0.297562688294999 0.295177320228084 0.207494710395988 0.041582796792736 0.266744906306357 -2.68140202202636 0.000502601558288905 0.00325480844276724 DOWN ENSG00000171631 P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 [Source:HGNC Symbol;Acc:HGNC:8543] GO:0040011|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0040012|GO:0045177|GO:0038023|GO:0048870|GO:0040017|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0051272|GO:0016323|GO:0006810|GO:0016324|GO:2000147|GO:0005887|GO:0004888|GO:0006928|GO:0031226|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009725|GO:0016021|GO:2000145|GO:0010033|GO:0007186|GO:0007166|GO:0033993|GO:0030334|GO:0006811|GO:0070542|GO:0014070|GO:0071310|GO:0030335|GO:0004930|GO:0032870|GO:0070633|GO:0030321|GO:0071398|GO:0006820|GO:0007200|GO:0014909|GO:0001614|GO:0014910|GO:0071407|GO:0014911|GO:0034695|GO:0071379|GO:0071396|GO:0035590|GO:0035589|GO:0015065|GO:0045028|GO:0015698|GO:0071380|GO:0006821|GO:0045029 locomotion|signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|regulation of locomotion|apical part of cell|signaling receptor activity|cell motility|positive regulation of locomotion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|positive regulation of cellular component movement|basolateral plasma membrane|transport|apical plasma membrane|positive regulation of cell motility|integral component of plasma membrane|transmembrane signaling receptor activity|movement of cell or subcellular component|intrinsic component of plasma membrane|cell communication|regulation of cellular component movement|cell migration|signal transduction|response to hormone|integral component of membrane|regulation of cell motility|response to organic substance|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|response to lipid|regulation of cell migration|ion transport|response to fatty acid|response to organic cyclic compound|cellular response to organic substance|positive regulation of cell migration|G-protein coupled receptor activity|cellular response to hormone stimulus|transepithelial transport|transepithelial chloride transport|cellular response to fatty acid|anion transport|phospholipase C-activating G-protein coupled receptor signaling pathway|smooth muscle cell migration|purinergic nucleotide receptor activity|regulation of smooth muscle cell migration|cellular response to organic cyclic compound|positive regulation of smooth muscle cell migration|response to prostaglandin E|cellular response to prostaglandin stimulus|cellular response to lipid|purinergic nucleotide receptor signaling pathway|G-protein coupled purinergic nucleotide receptor signaling pathway|uridine nucleotide receptor activity|G-protein coupled purinergic nucleotide receptor activity|inorganic anion transport|cellular response to prostaglandin E stimulus|chloride transport|UDP-activated nucleotide receptor activity K04272 purinergic receptor P2Y, G protein-coupled, 6[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 11:73264505-73298617 84 117 94 163 234 257 0.389733984746258 0.493352011538043 0.393218115635812 0.677602408812004 0.890786107732927 1.11750964610951 0.425434703973371 0.89529938755148 -1.0734324763498 0.000503458731256031 0.0032582390988332 DOWN ENSG00000255857 PXN-AS1 PXN antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44123] - - - - - - 12:120201291-120213138 10 11 12 47 38 21 0.180488805685545 0.180451836572502 0.195288753243318 0.76009285409624 0.562764150707441 0.3552288049076 0.185409798500455 0.559361936570427 -1.59306459548216 0.000504852362938813 0.00326513484470869 DOWN ENSG00000231125 AF129075.5 - - - - - - - 21:29058073-29060095 15 16 19 3 10 1 1.3363181041523 1.29546200663112 1.52613301481195 0.239433877474158 0.730982103838528 0.0834833065210555 1.38597104186512 0.351299762611247 1.98012260769745 0.000506475000392289 0.00327491978811163 UP ENSG00000178445 GLDC glycine dehydrogenase (decarboxylating) [Source:HGNC Symbol;Acc:HGNC:4313] GO:0009055|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0016491|GO:0043229|GO:0006807|GO:0016829|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0043234|GO:0006081|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0006520|GO:0043177|GO:0005960|GO:0016638|GO:0055114|GO:0009063|GO:0005759|GO:0005739|GO:0046487|GO:0031406|GO:0016594|GO:0005634|GO:0004375|GO:0046395|GO:0016597|GO:0019752|GO:0009069|GO:0006544|GO:0009071|GO:0032787|GO:0006546|GO:0019464 electron carrier activity|macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|lyase activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|protein complex|cellular aldehyde metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular amino acid metabolic process|organic acid binding|glycine cleavage complex|oxidoreductase activity, acting on the CH-NH2 group of donors|oxidation-reduction process|cellular amino acid catabolic process|mitochondrial matrix|mitochondrion|glyoxylate metabolic process|carboxylic acid binding|glycine binding|nucleus|glycine dehydrogenase (decarboxylating) activity|carboxylic acid catabolic process|amino acid binding|carboxylic acid metabolic process|serine family amino acid metabolic process|glycine metabolic process|serine family amino acid catabolic process|monocarboxylic acid metabolic process|glycine catabolic process|glycine decarboxylation via glycine cleavage system K00281 glycine dehydrogenase[1.4.4.2] hsa01100|hsa01200|hsa00260|hsa00630 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human)|Glyoxylate and dicarboxylate metabolism - Homo sapiens (human) 9:6532464-6645650 7 4 3 14 18 28 0.0854179870815257 0.0443590147173155 0.0329999623621307 0.153067437725666 0.180209267850074 0.320202246132019 0.0542589880536573 0.21782631723592 -2.00524422113557 0.000508376979892021 0.00328579483821095 DOWN ENSG00000270067 CTC-487M23.5 - - - - - - - 5:112893333-112894001 2 48 17 2 2 5 0.211460576825606 4.61254185320678 1.62061810129635 0.189479379990537 0.173495267294128 0.495514564482799 2.14820684377625 0.286163070589155 2.90822350331633 0.000509468475886402 0.0032921367703707 UP ENSG00000123384 LRP1 LDL receptor related protein 1 [Source:HGNC Symbol;Acc:HGNC:6692] GO:0040011|GO:0032502|GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0042995|GO:0097159|GO:0004872|GO:0030055|GO:0048523|GO:0051606|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0048870|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0031224|GO:0005905|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0048514|GO:0044255|GO:0045595|GO:0034185|GO:0008565|GO:0048468|GO:0043025|GO:0009314|GO:0006810|GO:0001568|GO:0010941|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0005102|GO:0005924|GO:0030900|GO:0005912|GO:0031982|GO:0051128|GO:0007420|GO:0009582|GO:0005887|GO:0043231|GO:0043169|GO:0019899|GO:0005774|GO:0005737|GO:0032970|GO:0060322|GO:0021987|GO:0032880|GO:0012506|GO:0043235|GO:0097242|GO:0051222|GO:0006928|GO:0032403|GO:0043005|GO:0030666|GO:0009966|GO:0045184|GO:0036477|GO:0060548|GO:0010646|GO:0031226|GO:0008104|GO:0007154|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0009968|GO:0008219|GO:0051271|GO:0021543|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:0030029|GO:2000145|GO:0021537|GO:0010876|GO:0019538|GO:2000146|GO:0032370|GO:0005768|GO:0006996|GO:0007568|GO:0050768|GO:0016192|GO:0005730|GO:0030111|GO:0006909|GO:0031175|GO:0007186|GO:0031344|GO:0030178|GO:1901215|GO:0046872|GO:0003723|GO:0007166|GO:0032956|GO:0001944|GO:0009583|GO:0007010|GO:0072358|GO:0007417|GO:0031410|GO:0043069|GO:0006720|GO:0070997|GO:0010721|GO:0051223|GO:0015031|GO:0070325|GO:0005773|GO:0030334|GO:0042953|GO:0016023|GO:0060840|GO:0070201|GO:0010640|GO:0048844|GO:0010642|GO:0007602|GO:0031345|GO:0002020|GO:0042157|GO:0031981|GO:0032368|GO:0030425|GO:0006869|GO:0031988|GO:1901214|GO:0030036|GO:0030336|GO:0012501|GO:0030659|GO:0033043|GO:0007399|GO:0030154|GO:0072359|GO:0005634|GO:0009416|GO:0043067|GO:0051960|GO:0005925|GO:0042954|GO:0048666|GO:0030182|GO:0016055|GO:0010975|GO:0032376|GO:0030139|GO:0000323|GO:0043523|GO:0014909|GO:0014910|GO:0005509|GO:0051493|GO:0007167|GO:0030135|GO:0009584|GO:0035909|GO:0015918|GO:0042981|GO:0035904|GO:0043066|GO:0044822|GO:0043277|GO:0051402|GO:0007603|GO:0045665|GO:0043524|GO:0006897|GO:0014912|GO:0022008|GO:0050767|GO:2000587|GO:0010977|GO:0007205|GO:0005765|GO:0006915|GO:0030136|GO:0010875|GO:0010517|GO:0005764|GO:0048699|GO:0032374|GO:0030301|GO:0006898|GO:0016101|GO:0045664|GO:0007169|GO:0048008|GO:0001523|GO:0033344|GO:0010874|GO:0032429|GO:0035791 locomotion|developmental process|macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|cell projection|organic cyclic compound binding|receptor activity|cell-substrate junction|negative regulation of cellular process|detection of stimulus|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|cell motility|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|intrinsic component of membrane|coated pit|regulation of developmental process|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|cellular lipid metabolic process|regulation of cell differentiation|apolipoprotein binding|protein transporter activity|cell development|neuronal cell body|response to radiation|transport|blood vessel development|regulation of cell death|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|receptor binding|cell-substrate adherens junction|forebrain development|adherens junction|vesicle|regulation of cellular component organization|brain development|detection of abiotic stimulus|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|enzyme binding|vacuolar membrane|cytoplasm|regulation of actin filament-based process|head development|cerebral cortex development|regulation of protein localization|vesicle membrane|receptor complex|beta-amyloid clearance|positive regulation of protein transport|movement of cell or subcellular component|protein complex binding|neuron projection|endocytic vesicle membrane|regulation of signal transduction|establishment of protein localization|somatodendritic compartment|negative regulation of cell death|regulation of cell communication|intrinsic component of plasma membrane|protein localization|cell communication|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|negative regulation of signal transduction|cell death|negative regulation of cellular component movement|pallium development|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|actin filament-based process|regulation of cell motility|telencephalon development|lipid localization|protein metabolic process|negative regulation of cell motility|positive regulation of lipid transport|endosome|organelle organization|aging|negative regulation of neurogenesis|vesicle-mediated transport|nucleolus|regulation of Wnt signaling pathway|phagocytosis|neuron projection development|G-protein coupled receptor signaling pathway|regulation of cell projection organization|negative regulation of Wnt signaling pathway|negative regulation of neuron death|metal ion binding|RNA binding|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|vasculature development|detection of light stimulus|cytoskeleton organization|cardiovascular system development|central nervous system development|cytoplasmic vesicle|negative regulation of programmed cell death|isoprenoid metabolic process|neuron death|negative regulation of cell development|regulation of protein transport|protein transport|lipoprotein particle receptor binding|vacuole|regulation of cell migration|lipoprotein transport|cytoplasmic, membrane-bounded vesicle|artery development|regulation of establishment of protein localization|regulation of platelet-derived growth factor receptor signaling pathway|artery morphogenesis|negative regulation of platelet-derived growth factor receptor signaling pathway|phototransduction|negative regulation of cell projection organization|protease binding|lipoprotein metabolic process|nuclear lumen|regulation of lipid transport|dendrite|lipid transport|membrane-bounded vesicle|regulation of neuron death|actin cytoskeleton organization|negative regulation of cell migration|programmed cell death|cytoplasmic vesicle membrane|regulation of organelle organization|nervous system development|cell differentiation|circulatory system development|nucleus|response to light stimulus|regulation of programmed cell death|regulation of nervous system development|focal adhesion|lipoprotein transporter activity|neuron development|neuron differentiation|Wnt signaling pathway|regulation of neuron projection development|positive regulation of cholesterol transport|endocytic vesicle|lytic vacuole|regulation of neuron apoptotic process|smooth muscle cell migration|regulation of smooth muscle cell migration|calcium ion binding|regulation of cytoskeleton organization|enzyme linked receptor protein signaling pathway|coated vesicle|detection of visible light|aorta morphogenesis|sterol transport|regulation of apoptotic process|aorta development|negative regulation of apoptotic process|poly(A) RNA binding|apoptotic cell clearance|neuron apoptotic process|phototransduction, visible light|negative regulation of neuron differentiation|negative regulation of neuron apoptotic process|endocytosis|negative regulation of smooth muscle cell migration|neurogenesis|regulation of neurogenesis|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of neuron projection development|protein kinase C-activating G-protein coupled receptor signaling pathway|lysosomal membrane|apoptotic process|clathrin-coated vesicle|positive regulation of cholesterol efflux|regulation of phospholipase activity|lysosome|generation of neurons|regulation of cholesterol transport|cholesterol transport|receptor-mediated endocytosis|diterpenoid metabolic process|regulation of neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|platelet-derived growth factor receptor signaling pathway|retinoid metabolic process|cholesterol efflux|regulation of cholesterol efflux|regulation of phospholipase A2 activity|platelet-derived growth factor receptor-beta signaling pathway K04550 low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor)[-] hsa05010|hsa05144 Alzheimer,s disease - Homo sapiens (human)|Malaria - Homo sapiens (human) 12:57128493-57213351 461 496 1255 1310 1392 3019 1.27891063575395 1.25055152092455 3.13904434397728 3.25618070882514 3.16845007404732 7.84931246601592 1.88950216688526 4.75798108296279 -1.33234336274519 0.000510085563609463 0.00329541104003396 DOWN ENSG00000212743 RP11-563J2.3 - - - - - - - 10:6350316-6352762 2 0 3 10 6 18 0.0578124748248182 0 0.0781776795313737 0.259014518213464 0.142298733738993 0.487652002574471 0.045330051452064 0.296321751508976 -2.70862482739382 0.000510375326394625 0.00329656966555282 DOWN ENSG00000240224 UGT1A5 UDP glucuronosyltransferase 1 family, polypeptide A5 [Source:HGNC Symbol;Acc:HGNC:12537] GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0071704|GO:0044237|GO:0009058|GO:0031224|GO:0016740|GO:0006082|GO:0009410|GO:0044281|GO:0005975|GO:0009812|GO:0016757|GO:0006805|GO:0016021|GO:0008194|GO:0052696|GO:0052697|GO:0016758|GO:0071466|GO:0005996|GO:0009813|GO:0015020|GO:0019752|GO:0032787|GO:0052695 membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|organic substance metabolic process|cellular metabolic process|biosynthetic process|intrinsic component of membrane|transferase activity|organic acid metabolic process|response to xenobiotic stimulus|small molecule metabolic process|carbohydrate metabolic process|flavonoid metabolic process|transferase activity, transferring glycosyl groups|xenobiotic metabolic process|integral component of membrane|UDP-glycosyltransferase activity|flavonoid glucuronidation|xenobiotic glucuronidation|transferase activity, transferring hexosyl groups|cellular response to xenobiotic stimulus|monosaccharide metabolic process|flavonoid biosynthetic process|glucuronosyltransferase activity|carboxylic acid metabolic process|monocarboxylic acid metabolic process|cellular glucuronidation K00699 glucuronosyltransferase[2.4.1.17] hsa01100|hsa05204|hsa00980|hsa00982|hsa00830|hsa00140|hsa00500|hsa00983|hsa00860|hsa00040|hsa00053 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Ascorbate and aldarate metabolism - Homo sapiens (human) 2:233712992-233773299 42 208 101 184 617 466 1.26692629668261 5.70224257247183 2.74687265705063 4.97300305773361 15.2705975013771 13.1740024593982 3.23868050873502 11.1392010061696 -1.78216769416725 0.000510763995779736 0.00329836650010993 DOWN ENSG00000269937 RP11-20I23.8 - - - - - - - 16:2561471-2565096 50 65 43 120 101 182 0.975402832130736 1.15242831213386 0.756303395843374 2.0974754109134 1.61661021695161 3.3274921429959 0.96137818003599 2.34719259028697 -1.28776025700696 0.000515398402815683 0.00332613573663195 DOWN ENSG00000213714 FAM209B family with sequence similarity 209 member B [Source:HGNC Symbol;Acc:HGNC:16101] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0043231|GO:0016021|GO:0005634 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|intracellular membrane-bounded organelle|integral component of membrane|nucleus - - - - 20:56533246-56536520 7 1 6 0 0 0 0.713498661544098 0.092676839678587 0.551395262219425 0 0 0 0.452523587814037 0 Inf 0.000516234010235874 0.00333080832971294 UP ENSG00000258471 RP11-84C10.4 - - - - - - - 14:20995837-20999163 10 11 13 2 4 3 0.505962538971138 0.505858903810897 0.593048141473825 0.0906736088795919 0.166049118483221 0.142244088793386 0.534956528085287 0.132988938718733 2.00811540388862 0.000516951419137805 0.0033347164362446 UP ENSG00000237719 RP1-179N16.3 - - - - - - - 6:36091991-36092646 0 3 1 13 11 5 0 0.294043187340058 0.0971717649692751 1.25597412314456 0.973178196163431 0.505334212864317 0.130404984103111 0.911495510724103 -2.80523654005521 0.000525782041378538 0.00338436762900278 DOWN ENSG00000230183 CNOT6LP1 CCR4-NOT transcription complex subunit 6-like pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:32355] - - - - - - 15:56005715-56007176 6 8 13 24 29 30 0.290288220033509 0.351777302758246 0.567087073721208 1.04040789627359 1.15121615759924 1.36036554605551 0.403050865504321 1.18399653330945 -1.55463103161838 0.000526402237958828 0.00338762931925476 DOWN ENSG00000123453 SARDH sarcosine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:10536] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0033218|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0072341|GO:0043227|GO:0048037|GO:0005622|GO:0006575|GO:0005542|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0043168|GO:0044281|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0043177|GO:0051186|GO:0019842|GO:0050662|GO:0000166|GO:0006730|GO:0055114|GO:0050660|GO:0035999|GO:0042558|GO:0005759|GO:0005739|GO:0043603|GO:0031406|GO:0006760|GO:0008480|GO:0046653|GO:0016597|GO:0019752 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|amide binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|modified amino acid binding|membrane-bounded organelle|cofactor binding|intracellular|cellular modified amino acid metabolic process|folic acid binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|organic acid binding|cofactor metabolic process|vitamin binding|coenzyme binding|nucleotide binding|one-carbon metabolic process|oxidation-reduction process|flavin adenine dinucleotide binding|tetrahydrofolate interconversion|pteridine-containing compound metabolic process|mitochondrial matrix|mitochondrion|cellular amide metabolic process|carboxylic acid binding|folic acid-containing compound metabolic process|sarcosine dehydrogenase activity|tetrahydrofolate metabolic process|amino acid binding|carboxylic acid metabolic process K00314 sarcosine dehydrogenase[1.5.8.3] hsa01100|hsa00260 Metabolic pathways - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human) 9:133663560-133739955 4 4 9 19 14 43 0.0403788000274954 0.0366989022857539 0.0819136711564939 0.171857305612079 0.115960676193426 0.406827406164391 0.0529971244899144 0.231548462656632 -2.12732818906143 0.000535362036623082 0.00343713940674097 DOWN ENSG00000248015 AC005329.7 - - - - - - - 19:1392170-1396467 11 22 40 6 10 7 0.206065233819985 0.37455525575729 0.675597280591844 0.100711100540521 0.153707571622826 0.122900088557847 0.41873925672304 0.125772920240398 1.73523084313415 0.00053601787539931 0.00343987051852343 UP ENSG00000137965 IFI44 interferon induced protein 44 [Source:HGNC Symbol;Acc:HGNC:16938] GO:0005623|GO:0050896|GO:0051707|GO:0009607|GO:0009605|GO:0005622|GO:0005737|GO:0009615 cell|response to stimulus|response to other organism|response to biotic stimulus|response to external stimulus|intracellular|cytoplasm|response to virus - - - - 1:78649796-78664078 51 107 103 39 40 48 0.970300527899048 1.85012688195759 1.76680271241989 0.66480825022821 0.624405874244818 0.855873824269198 1.52907670742551 0.715029316247409 1.09658648372567 0.000537415691459054 0.00344809973196188 UP ENSG00000171757 LRRC34 leucine rich repeat containing 34 [Source:HGNC Symbol;Acc:HGNC:28408] GO:0005488|GO:0005515 binding|protein binding - - - - 3:169793428-169812986 62 67 84 153 180 124 0.468055462714293 0.459688331265264 0.571742035327264 1.03488983977369 1.11492502667734 0.877320189764469 0.49982860976894 1.0090450187385 -1.0134851544476 0.00053993454819853 0.00346351654531992 DOWN ENSG00000169891 REPS2 RALBP1 associated Eps domain containing 2 [Source:HGNC Symbol;Acc:HGNC:9963] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043167|GO:0016043|GO:0005622|GO:0005515|GO:0022607|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0046872|GO:0007166|GO:0006461|GO:0005509|GO:0007167|GO:0007169|GO:0038127|GO:0007173 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|ion binding|cellular component organization|intracellular|protein binding|cellular component assembly|cation binding|cytoplasm|cell communication|signal transduction|metal ion binding|cell surface receptor signaling pathway|protein complex assembly|calcium ion binding|enzyme linked receptor protein signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - X:16946691-17153280 13 16 73 102 89 200 0.0501920991649252 0.0561430507758917 0.254118097987527 0.352854899364718 0.281939776417658 0.723696385434925 0.120151082642781 0.4528303537391 -1.91412101873034 0.000542164958857092 0.00347707683817822 DOWN ENSG00000254093 PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:30046] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0009058|GO:0030234|GO:0005622|GO:1903829|GO:0005515|GO:0043234|GO:0019222|GO:0060341|GO:0032205|GO:0042127|GO:0007049|GO:0004857|GO:0006725|GO:0051640|GO:0022402|GO:1901360|GO:0003676|GO:0034641|GO:0000776|GO:0032204|GO:0046483|GO:0051128|GO:0051098|GO:0043231|GO:0000723|GO:0005737|GO:0032880|GO:0042592|GO:0051656|GO:0009890|GO:0006139|GO:1900182|GO:0008104|GO:0044092|GO:0031647|GO:0051649|GO:0008285|GO:0050790|GO:0007059|GO:0043086|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0005730|GO:0032268|GO:0007004|GO:0000819|GO:0034645|GO:0051053|GO:0051101|GO:0003723|GO:0010833|GO:1903047|GO:0043412|GO:0007080|GO:0036211|GO:0032269|GO:0000278|GO:0031981|GO:0010521|GO:0051099|GO:0006259|GO:0005739|GO:0005694|GO:0000228|GO:0034613|GO:0033043|GO:0044267|GO:0007067|GO:0051246|GO:1904356|GO:0009059|GO:1903827|GO:0005856|GO:0005634|GO:0005819|GO:0000777|GO:1904357|GO:0051303|GO:1904751|GO:0008156|GO:0033365|GO:0032200|GO:0006260|GO:0000781|GO:2001251|GO:2000279|GO:0051972|GO:0000793|GO:0033044|GO:0043388|GO:2000278|GO:0015630|GO:0006275|GO:0032211|GO:0000070|GO:0000784|GO:0051310|GO:0070034|GO:1900180|GO:0006464|GO:0071897|GO:0051974|GO:0032210|GO:0000775|GO:0006278|GO:0034502|GO:0000779|GO:1904744|GO:0034504|GO:0032446|GO:0070198|GO:0031396|GO:0031397|GO:1902570|GO:0016567 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|biosynthetic process|enzyme regulator activity|intracellular|positive regulation of cellular protein localization|protein binding|protein complex|regulation of metabolic process|regulation of cellular localization|negative regulation of telomere maintenance|regulation of cell proliferation|cell cycle|enzyme inhibitor activity|cellular aromatic compound metabolic process|organelle localization|cell cycle process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|kinetochore|regulation of telomere maintenance|heterocycle metabolic process|regulation of cellular component organization|regulation of binding|intracellular membrane-bounded organelle|telomere maintenance|cytoplasm|regulation of protein localization|homeostatic process|establishment of organelle localization|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|positive regulation of protein localization to nucleus|protein localization|negative regulation of molecular function|regulation of protein stability|establishment of localization in cell|negative regulation of cell proliferation|regulation of catalytic activity|chromosome segregation|negative regulation of catalytic activity|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|nucleolus|regulation of cellular protein metabolic process|telomere maintenance via telomerase|sister chromatid segregation|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|regulation of DNA binding|RNA binding|telomere maintenance via telomere lengthening|mitotic cell cycle process|macromolecule modification|mitotic metaphase plate congression|protein modification process|negative regulation of cellular protein metabolic process|mitotic cell cycle|nuclear lumen|telomerase inhibitor activity|positive regulation of binding|DNA metabolic process|mitochondrion|chromosome|nuclear chromosome|cellular protein localization|regulation of organelle organization|cellular protein metabolic process|mitotic nuclear division|regulation of protein metabolic process|regulation of telomere maintenance via telomere lengthening|macromolecule biosynthetic process|regulation of cellular protein localization|cytoskeleton|nucleus|spindle|condensed chromosome kinetochore|negative regulation of telomere maintenance via telomere lengthening|establishment of chromosome localization|positive regulation of protein localization to nucleolus|negative regulation of DNA replication|protein localization to organelle|telomere organization|DNA replication|chromosome, telomeric region|negative regulation of chromosome organization|negative regulation of DNA biosynthetic process|regulation of telomerase activity|condensed chromosome|regulation of chromosome organization|positive regulation of DNA binding|regulation of DNA biosynthetic process|microtubule cytoskeleton|regulation of DNA replication|negative regulation of telomere maintenance via telomerase|mitotic sister chromatid segregation|nuclear chromosome, telomeric region|metaphase plate congression|telomerase RNA binding|regulation of protein localization to nucleus|cellular protein modification process|DNA biosynthetic process|negative regulation of telomerase activity|regulation of telomere maintenance via telomerase|chromosome, centromeric region|RNA-dependent DNA replication|protein localization to chromosome|condensed chromosome, centromeric region|positive regulation of telomeric DNA binding|protein localization to nucleus|protein modification by small protein conjugation|protein localization to chromosome, telomeric region|regulation of protein ubiquitination|negative regulation of protein ubiquitination|protein localization to nucleolus|protein ubiquitination - - - - 8:10764963-10839884 37 59 45 158 137 73 0.582644973398365 0.844385852030937 0.638894082217609 2.22926405182984 1.7700874932033 1.07735842905767 0.688641635882304 1.69223665803027 -1.29710602711352 0.000543432332840112 0.00348370815215991 DOWN ENSG00000185115 NDNL2 NSE3 homolog, SMC5-SMC6 complex component [Source:HGNC Symbol;Acc:HGNC:7677] GO:0040007|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0043227|GO:0040008|GO:0009893|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006281|GO:0006725|GO:1901360|GO:0034641|GO:0031325|GO:0046483|GO:0033554|GO:0030915|GO:0043231|GO:0005737|GO:0006139|GO:0019538|GO:0031323|GO:0032268|GO:0043412|GO:0036211|GO:0031981|GO:0051247|GO:0005654|GO:0006259|GO:0005694|GO:0032270|GO:0044267|GO:0051246|GO:0005634|GO:0006974|GO:0031401|GO:0000781|GO:0000793|GO:0006310|GO:0006464|GO:0018193|GO:0043687|GO:0032446|GO:0031398|GO:0031396|GO:0018205|GO:0016925|GO:0016567 growth|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|regulation of growth|positive regulation of metabolic process|intracellular|protein binding|protein complex|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|Smc5-Smc6 complex|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|protein modification process|nuclear lumen|positive regulation of protein metabolic process|nucleoplasm|DNA metabolic process|chromosome|positive regulation of cellular protein metabolic process|cellular protein metabolic process|regulation of protein metabolic process|nucleus|cellular response to DNA damage stimulus|positive regulation of protein modification process|chromosome, telomeric region|condensed chromosome|DNA recombination|cellular protein modification process|peptidyl-amino acid modification|post-translational protein modification|protein modification by small protein conjugation|positive regulation of protein ubiquitination|regulation of protein ubiquitination|peptidyl-lysine modification|protein sumoylation|protein ubiquitination - - - - 15:29268149-29269829 238 184 162 111 127 67 10.0151000077633 7.03680165529374 6.1462090601146 4.18503880167549 4.38479073707402 2.64230165039282 7.73270357439055 3.73737706304744 1.04894678560055 0.000543796430722109 0.00348529382627262 UP ENSG00000255983 RP11-1038A11.1 - - - - - - - 12:5388589-5406651 0 0 2 5 7 9 0 0 0.0907872626287737 0.225531817742456 0.289158881881614 0.424656388007021 0.0302624208762579 0.31311569587703 -3.37109652247853 0.000544092277304754 0.0034864414781404 DOWN ENSG00000241112 RPL29P14 ribosomal protein L29 pseudogene 14 [Source:HGNC Symbol;Acc:HGNC:36687] - - - - - - 5:149545383-149545810 9 9 3 1 0 1 1.48746541356994 1.35190687703153 0.446964443488952 0.148011199768252 0 0.154873236863827 1.09544557803014 0.10096147887736 3.43964095950498 0.000547401202452447 0.00350538727971157 UP ENSG00000176533 GNG7 guanine nucleotide binding protein (G protein), gamma 7 [Source:HGNC Symbol;Acc:HGNC:4410] GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:1903561|GO:0051716|GO:0019898|GO:0050794|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0043234|GO:0009898|GO:0098797|GO:0015980|GO:0044281|GO:0031982|GO:0010243|GO:0007267|GO:0031234|GO:0098562|GO:0009966|GO:0019897|GO:0010646|GO:0007154|GO:0007165|GO:0070062|GO:0009725|GO:0005834|GO:0006091|GO:0010033|GO:0055114|GO:0007186|GO:0008277|GO:1901652|GO:0071417|GO:0043434|GO:0006112|GO:0071310|GO:0032870|GO:1901653|GO:0071375|GO:0033762|GO:0071377|GO:0007268 macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|regulation of cellular process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|protein complex|cytoplasmic side of plasma membrane|plasma membrane protein complex|energy derivation by oxidation of organic compounds|small molecule metabolic process|vesicle|response to organonitrogen compound|cell-cell signaling|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|regulation of signal transduction|extrinsic component of plasma membrane|regulation of cell communication|cell communication|signal transduction|extracellular exosome|response to hormone|heterotrimeric G-protein complex|generation of precursor metabolites and energy|response to organic substance|oxidation-reduction process|G-protein coupled receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|response to peptide|cellular response to organonitrogen compound|response to peptide hormone|energy reserve metabolic process|cellular response to organic substance|cellular response to hormone stimulus|cellular response to peptide|cellular response to peptide hormone stimulus|response to glucagon|cellular response to glucagon stimulus|synaptic transmission K04543 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7[-] hsa04740|hsa05200|hsa04151|hsa04014|hsa04062|hsa05034|hsa04728|hsa04724|hsa04726|hsa04725|hsa04723|hsa04713|hsa05032|hsa04727 Olfactory transduction - Homo sapiens (human)|Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human) 19:2511219-2702709 29 29 117 134 157 308 0.434981492137433 0.395327011227923 1.58224453196165 1.80084346405167 1.93214047477012 4.3296327776403 0.804184345109002 2.68753890548736 -1.7406874827915 0.000547638458832676 0.00350615452498192 DOWN ENSG00000181619 GPR135 G protein-coupled receptor 135 [Source:HGNC Symbol;Acc:HGNC:19991] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0004930 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor activity - - - - 14:59429022-59465342 62 78 37 131 164 153 0.616139320825081 0.704468890442178 0.331519324206453 1.16642359645141 1.33720746109294 1.42497728916804 0.550709178491237 1.3095361155708 -1.24969328945312 0.000549114405097775 0.00351183835685282 DOWN ENSG00000279513 RP4-675C20.4 - - - - - - - 1:117493515-117495006 0 0 0 3 4 7 0 0 0 0.127419905304612 0.155587578846879 0.311039366216105 0 0.198015616789199 -Inf 0.000549036992946977 0.00351183835685282 DOWN ENSG00000235724 AC009299.2 - - - - - - - 2:161222785-161308303 2 2 4 12 10 16 0.027220920895965 0.0247401585834402 0.0490883602052827 0.146347937518187 0.111679774956281 0.204101012034692 0.0336831465615626 0.15404290816972 -2.19323344375554 0.00055363670201291 0.00353697198842145 DOWN ENSG00000123901 GPR83 G protein-coupled receptor 83 [Source:HGNC Symbol;Acc:HGNC:4523] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0042995|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0005929|GO:0005887|GO:0004888|GO:0072372|GO:0031226|GO:0007154|GO:0007165|GO:0009725|GO:0016021|GO:0010033|GO:0007186|GO:0007166|GO:0033993|GO:0014070|GO:0008528|GO:0004930|GO:0048545|GO:0031513|GO:0008188|GO:0007218|GO:0031960|GO:0051384|GO:0004983 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|cell projection|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|cilium|integral component of plasma membrane|transmembrane signaling receptor activity|primary cilium|intrinsic component of plasma membrane|cell communication|signal transduction|response to hormone|integral component of membrane|response to organic substance|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|response to lipid|response to organic cyclic compound|G-protein coupled peptide receptor activity|G-protein coupled receptor activity|response to steroid hormone|nonmotile primary cilium|neuropeptide receptor activity|neuropeptide signaling pathway|response to corticosteroid|response to glucocorticoid|neuropeptide Y receptor activity K04210 G protein-coupled receptor 83[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 11:94377311-94401419 17 15 6 4 2 3 0.198531236683714 0.159210823154022 0.0631778623048178 0.0418562671994946 0.0191626768730018 0.0328309783941149 0.140306640714185 0.0312833074888704 2.16511833576235 0.000553958400300043 0.00353827002194212 UP ENSG00000037897 METTL1 methyltransferase like 1 [Source:HGNC Symbol;Acc:HGNC:7030] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0005730|GO:0008168|GO:0003723|GO:0043412|GO:0001510|GO:0031981|GO:1990234|GO:0005654|GO:0043527|GO:0010467|GO:0016070|GO:0005634|GO:0000049|GO:0036265|GO:0006396|GO:0034660|GO:0009451|GO:0030488|GO:0008173|GO:0008757|GO:0006400|GO:0016423|GO:0006399|GO:0008175|GO:0008033|GO:0009452|GO:0008176 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|protein complex|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nucleolus|methyltransferase activity|RNA binding|macromolecule modification|RNA methylation|nuclear lumen|transferase complex|nucleoplasm|tRNA methyltransferase complex|gene expression|RNA metabolic process|nucleus|tRNA binding|RNA (guanine-N7)-methylation|RNA processing|ncRNA metabolic process|RNA modification|tRNA methylation|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|tRNA modification|tRNA (guanine) methyltransferase activity|tRNA metabolic process|tRNA methyltransferase activity|tRNA processing|7-methylguanosine RNA capping|tRNA (guanine-N7-)-methyltransferase activity - - - - 12:57768471-57772793 123 161 101 62 86 34 1.60380809931652 1.9078868312236 1.18735785820898 0.724328963170444 0.920052918404383 0.415483393519635 1.56635092958303 0.686621758364821 1.18981999350716 0.000556787889126918 0.00355406150138871 UP ENSG00000249898 MCPH1-AS1 MCPH1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51655] - - - - - - 8:6618475-6708209 3 2 11 22 20 19 0.0553846083817703 0.0335528716487837 0.18307024994441 0.363860813971377 0.302907479004867 0.328697858997246 0.090669243324988 0.33182205065783 -1.87172461111247 0.000560432984798036 0.00357530555750955 DOWN ENSG00000259863 SH3RF3-AS1 SH3RF3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44168] - - - - - - 2:109127327-109128930 0 3 2 5 13 16 0 0.120257064149051 0.0795237556068747 0.197551249331765 0.470369844453231 0.6612923687932 0.0665936065853086 0.443071154192732 -2.73408282327694 0.000560475313497176 0.00357530555750955 DOWN ENSG00000064787 BCAS1 breast carcinoma amplified sequence 1 [Source:HGNC Symbol;Acc:HGNC:974] GO:0045202|GO:0005623|GO:0005576|GO:1903561|GO:0060076|GO:0043229|GO:0043227|GO:0005622|GO:0031982|GO:0005737|GO:0014069|GO:0070062 synapse|cell|extracellular region|extracellular vesicle|excitatory synapse|intracellular organelle|membrane-bounded organelle|intracellular|vesicle|cytoplasm|postsynaptic density|extracellular exosome - - - - 20:53936777-54070594 11 12 17 32 23 150 0.0739008759525372 0.0732688408157312 0.102972125535878 0.192622581936239 0.1267806079353 0.944451620112541 0.0833806141013821 0.42128493666136 -2.33701242944674 0.000561976960019347 0.00358335330295121 DOWN ENSG00000159374 M1AP meiosis 1 associated protein [Source:HGNC Symbol;Acc:HGNC:25183] GO:0032502|GO:0000003|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0019953|GO:0044237|GO:0016043|GO:0032504|GO:0031224|GO:0005622|GO:0005515|GO:0048609|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0046483|GO:0022607|GO:0005737|GO:0051307|GO:0006139|GO:0007276|GO:0007126|GO:0007059|GO:0048869|GO:0016021|GO:0006996|GO:0051276|GO:0048232|GO:0051304|GO:0006325|GO:0007140|GO:0045132|GO:0051308|GO:0010467|GO:0030154|GO:0016070|GO:0007292|GO:0007283|GO:0006396|GO:0007060|GO:0006333|GO:0031497|GO:0071103|GO:0006323 developmental process|reproduction|cell|membrane|cellular process|reproductive process|metabolic process|binding|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|sexual reproduction|cellular metabolic process|cellular component organization|multicellular organism reproduction|intrinsic component of membrane|intracellular|protein binding|multicellular organismal reproductive process|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|cytoplasm|meiotic chromosome separation|nucleobase-containing compound metabolic process|gamete generation|meiotic nuclear division|chromosome segregation|cellular developmental process|integral component of membrane|organelle organization|chromosome organization|male gamete generation|chromosome separation|chromatin organization|male meiosis|meiotic chromosome segregation|male meiosis chromosome separation|gene expression|cell differentiation|RNA metabolic process|female gamete generation|spermatogenesis|RNA processing|male meiosis chromosome segregation|chromatin assembly or disassembly|chromatin assembly|DNA conformation change|DNA packaging - - - - 2:74557883-74648338 44 51 65 127 126 97 0.679565347514641 0.715869613687863 0.905125165339688 1.75744099325629 1.59668736305371 1.40403776984565 0.766853375514064 1.58605537538522 -1.04842048010983 0.000562453797681188 0.00358562794703698 DOWN ENSG00000137745 MMP13 matrix metallopeptidase 13 [Source:HGNC Symbol;Acc:HGNC:7159] GO:0032502|GO:0031012|GO:0040007|GO:0032991|GO:0000003|GO:0005623|GO:0048511|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0042698|GO:0044237|GO:0051641|GO:0003006|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0032504|GO:0016787|GO:0005615|GO:0048589|GO:0005622|GO:0022602|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0048609|GO:0007507|GO:0045137|GO:0060341|GO:0001554|GO:0009888|GO:0006810|GO:0009612|GO:0034405|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0043062|GO:0032940|GO:0033554|GO:0044849|GO:0035265|GO:0043231|GO:0048608|GO:0043169|GO:0008233|GO:0005737|GO:0032880|GO:0060351|GO:0051222|GO:0009887|GO:0032403|GO:0048598|GO:0007548|GO:0045184|GO:0048306|GO:0001968|GO:0042493|GO:0044236|GO:0008104|GO:0008406|GO:0001503|GO:0007586|GO:0009725|GO:0060348|GO:0001666|GO:0051047|GO:0048869|GO:0005581|GO:0019538|GO:0010033|GO:0060456|GO:0050878|GO:0046581|GO:0005794|GO:0007567|GO:0048705|GO:0030574|GO:0044259|GO:0071498|GO:0044058|GO:0030157|GO:0051216|GO:0006518|GO:0046872|GO:0033993|GO:0008585|GO:0043171|GO:0022617|GO:0061458|GO:0007589|GO:0072358|GO:0051223|GO:0005518|GO:0090187|GO:0015031|GO:0070325|GO:0031214|GO:0005773|GO:0009790|GO:0046545|GO:0003417|GO:0070201|GO:0050714|GO:0001649|GO:0051046|GO:0009306|GO:0006508|GO:0098868|GO:0014070|GO:0043603|GO:0035108|GO:0044267|GO:0046903|GO:0060349|GO:0030198|GO:0030154|GO:0001501|GO:0061448|GO:0060173|GO:0072359|GO:0030282|GO:0048545|GO:0008237|GO:0000323|GO:0060350|GO:0050708|GO:0043627|GO:0005509|GO:0004175|GO:0046914|GO:1904244|GO:0001958|GO:0003416|GO:0050750|GO:0035137|GO:0030326|GO:0032963|GO:0035116|GO:0005764|GO:0008270|GO:0004222 developmental process|extracellular matrix|growth|macromolecular complex|reproduction|cell|rhythmic process|cellular process|extracellular region|reproductive process|metabolic process|cell junction|response to stimulus|binding|catalytic activity|cellular response to stimulus|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|ovulation cycle|cellular metabolic process|cellular localization|developmental process involved in reproduction|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|multicellular organism reproduction|hydrolase activity|extracellular space|developmental growth|intracellular|ovulation cycle process|protein binding|protein complex|endomembrane system|anatomical structure development|multicellular organismal reproductive process|heart development|development of primary sexual characteristics|regulation of cellular localization|luteolysis|tissue development|transport|response to mechanical stimulus|response to fluid shear stress|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|extracellular structure organization|secretion by cell|cellular response to stress|estrous cycle|organ growth|intracellular membrane-bounded organelle|reproductive structure development|cation binding|peptidase activity|cytoplasm|regulation of protein localization|cartilage development involved in endochondral bone morphogenesis|positive regulation of protein transport|organ morphogenesis|protein complex binding|embryonic morphogenesis|sex differentiation|establishment of protein localization|calcium-dependent protein binding|fibronectin binding|response to drug|multicellular organism metabolic process|protein localization|gonad development|ossification|digestion|response to hormone|bone development|response to hypoxia|positive regulation of secretion|cellular developmental process|collagen trimer|protein metabolic process|response to organic substance|positive regulation of digestive system process|regulation of body fluid levels|intercellular canaliculus|Golgi apparatus|parturition|skeletal system morphogenesis|collagen catabolic process|multicellular organismal macromolecule metabolic process|cellular response to fluid shear stress|regulation of digestive system process|pancreatic juice secretion|cartilage development|peptide metabolic process|metal ion binding|response to lipid|female gonad development|peptide catabolic process|extracellular matrix disassembly|reproductive system development|body fluid secretion|cardiovascular system development|regulation of protein transport|collagen binding|positive regulation of pancreatic juice secretion|protein transport|lipoprotein particle receptor binding|biomineral tissue development|vacuole|embryo development|development of primary female sexual characteristics|growth plate cartilage development|regulation of establishment of protein localization|positive regulation of protein secretion|osteoblast differentiation|regulation of secretion|protein secretion|proteolysis|bone growth|response to organic cyclic compound|cellular amide metabolic process|limb morphogenesis|cellular protein metabolic process|secretion|bone morphogenesis|extracellular matrix organization|cell differentiation|skeletal system development|connective tissue development|limb development|circulatory system development|bone mineralization|response to steroid hormone|metallopeptidase activity|lytic vacuole|endochondral bone morphogenesis|regulation of protein secretion|response to estrogen|calcium ion binding|endopeptidase activity|transition metal ion binding|positive regulation of pancreatic trypsinogen secretion|endochondral ossification|endochondral bone growth|low-density lipoprotein particle receptor binding|hindlimb morphogenesis|embryonic limb morphogenesis|collagen metabolic process|embryonic hindlimb morphogenesis|lysosome|zinc ion binding|metalloendopeptidase activity - - - - 11:102942995-102955734 10 15 16 31 34 58 0.228763140194583 0.311882262562714 0.330028729607832 0.635417287675876 0.63818820104592 1.24355331473495 0.290224710788376 0.839052934485582 -1.5315914698791 0.000562730750202472 0.00358662762949287 DOWN ENSG00000215374 FAM66B family with sequence similarity 66 member B [Source:HGNC Symbol;Acc:HGNC:28890] - - - - - - 8:7301611-7355354 1 2 1 7 9 10 0.0174216379671624 0.0316530290886605 0.0156929290546146 0.109215634943826 0.128590980517833 0.163202356112157 0.0215891987034792 0.133669657191272 -2.63029041007295 0.000565284783818383 0.00360059994369831 DOWN ENSG00000197587 DMBX1 diencephalon/mesencephalon homeobox 1 [Source:HGNC Symbol;Acc:HGNC:19026] GO:0032502|GO:0040007|GO:0032991|GO:0007610|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0007631|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0044708|GO:0009058|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0007626|GO:0048856|GO:0019222|GO:0042802|GO:0008344|GO:0006725|GO:0030534|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0008343|GO:0046483|GO:0007420|GO:0043231|GO:0000981|GO:0060322|GO:0005667|GO:0046983|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0007417|GO:0010629|GO:0046982|GO:0051252|GO:0010467|GO:0007399|GO:0001227|GO:0009059|GO:0016070|GO:0005634|GO:0042803|GO:0000975|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0000977 developmental process|growth|macromolecular complex|behavior|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|feeding behavior|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|single-organism behavior|biosynthetic process|developmental growth|intracellular|protein binding|protein complex|locomotory behavior|anatomical structure development|regulation of metabolic process|identical protein binding|adult locomotory behavior|cellular aromatic compound metabolic process|adult behavior|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|adult feeding behavior|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|head development|transcription factor complex|protein dimerization activity|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|central nervous system development|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|gene expression|nervous system development|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|macromolecule biosynthetic process|RNA metabolic process|nucleus|protein homodimerization activity|regulatory region DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 1:46506996-46514226 25 32 75 96 106 152 0.326702099598646 0.380046862466326 0.883660405915926 1.12402909581009 1.13652845776657 1.86157446867179 0.530136455993633 1.37404400741615 -1.37399255182757 0.000567091835201099 0.00361056934273696 DOWN ENSG00000143434 SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C [Source:HGNC Symbol;Acc:HGNC:10740] GO:0040011|GO:0032502|GO:0040007|GO:0045499|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0048523|GO:0048521|GO:0050794|GO:0040012|GO:0016049|GO:0050795|GO:0048870|GO:0045926|GO:0040017|GO:0009653|GO:0016043|GO:0071944|GO:0040008|GO:0009605|GO:0031224|GO:0050793|GO:0048589|GO:0005515|GO:0005886|GO:0048856|GO:0051272|GO:0006935|GO:0045595|GO:0009888|GO:0048468|GO:0007275|GO:0045596|GO:0048513|GO:0032535|GO:0005102|GO:0051128|GO:2000147|GO:0005887|GO:0030308|GO:0050920|GO:0006928|GO:0031226|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0048588|GO:0048638|GO:0050922|GO:0051271|GO:0048640|GO:0030030|GO:0048869|GO:0016021|GO:2000145|GO:0001558|GO:0060560|GO:0050768|GO:0000902|GO:0031175|GO:0031344|GO:0007166|GO:0010721|GO:0000904|GO:0050919|GO:0030334|GO:0001667|GO:0030517|GO:0031345|GO:0060485|GO:0008361|GO:0022604|GO:0048864|GO:0030516|GO:0032990|GO:0030215|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0030335|GO:1902667|GO:1990138|GO:0051960|GO:0048666|GO:0030182|GO:0007411|GO:0001755|GO:0048863|GO:0010975|GO:0010769|GO:0048841|GO:0014031|GO:0061564|GO:0048762|GO:0045665|GO:0071526|GO:0022008|GO:0048667|GO:0050767|GO:0048843|GO:0048812|GO:0010977|GO:0050771|GO:0048675|GO:0014033|GO:0014032|GO:0007409|GO:0048699|GO:0048846|GO:0050770|GO:0045664 locomotion|developmental process|growth|chemorepellent activity|behavior|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of cellular process|negative regulation of behavior|regulation of cellular process|regulation of locomotion|cell growth|regulation of behavior|cell motility|negative regulation of growth|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|cell periphery|regulation of growth|response to external stimulus|intrinsic component of membrane|regulation of developmental process|developmental growth|protein binding|plasma membrane|anatomical structure development|positive regulation of cellular component movement|chemotaxis|regulation of cell differentiation|tissue development|cell development|multicellular organism development|negative regulation of cell differentiation|animal organ development|regulation of cellular component size|receptor binding|regulation of cellular component organization|positive regulation of cell motility|integral component of plasma membrane|negative regulation of cell growth|regulation of chemotaxis|movement of cell or subcellular component|intrinsic component of plasma membrane|cell communication|regulation of cellular component movement|cell migration|signal transduction|developmental cell growth|regulation of developmental growth|negative regulation of chemotaxis|negative regulation of cellular component movement|negative regulation of developmental growth|cell projection organization|cellular developmental process|integral component of membrane|regulation of cell motility|regulation of cell growth|developmental growth involved in morphogenesis|negative regulation of neurogenesis|cell morphogenesis|neuron projection development|regulation of cell projection organization|cell surface receptor signaling pathway|negative regulation of cell development|cell morphogenesis involved in differentiation|negative chemotaxis|regulation of cell migration|ameboidal-type cell migration|negative regulation of axon extension|negative regulation of cell projection organization|mesenchyme development|regulation of cell size|regulation of cell morphogenesis|stem cell development|regulation of axon extension|cell part morphogenesis|semaphorin receptor binding|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|positive regulation of cell migration|regulation of axon guidance|neuron projection extension|regulation of nervous system development|neuron development|neuron differentiation|axon guidance|neural crest cell migration|stem cell differentiation|regulation of neuron projection development|regulation of cell morphogenesis involved in differentiation|regulation of axon extension involved in axon guidance|mesenchymal cell development|axon development|mesenchymal cell differentiation|negative regulation of neuron differentiation|semaphorin-plexin signaling pathway|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|negative regulation of axon extension involved in axon guidance|neuron projection morphogenesis|negative regulation of neuron projection development|negative regulation of axonogenesis|axon extension|neural crest cell differentiation|neural crest cell development|axonogenesis|generation of neurons|axon extension involved in axon guidance|regulation of axonogenesis|regulation of neuron differentiation K06842 semaphorin 6[-] hsa04360 Axon guidance - Homo sapiens (human) 1:151131685-151146664 79 99 128 35 39 72 0.541753115484846 0.617011471690329 0.791409637471461 0.215049313031619 0.219435561110798 0.462737547377501 0.650058074882212 0.299074140506639 1.12006543838216 0.000568339894668698 0.00361774396917683 UP ENSG00000235531 MSC-AS1 MSC antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:48724] - - - - - - 8:71828167-72118393 0 0 0 2 4 10 0 0 0 0.0138114736558803 0.0252927290956138 0.072230112282369 0 0.037111438344621 -Inf 0.000569582898961234 0.00362488336507966 DOWN ENSG00000233608 TWIST2 twist family bHLH transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:20670] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0019222|GO:0045595|GO:0006725|GO:1901360|GO:0010941|GO:0003676|GO:0045596|GO:0030279|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0046983|GO:0009890|GO:0060548|GO:0006139|GO:0030278|GO:0001503|GO:0008219|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0045668|GO:0010629|GO:0043069|GO:0051252|GO:0045667|GO:0001649|GO:0012501|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0043067|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0042981|GO:0043066|GO:0006351|GO:0006915|GO:0006355|GO:1903507|GO:1903506 developmental process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|protein binding|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|regulation of cell death|nucleic acid binding|negative regulation of cell differentiation|negative regulation of ossification|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|negative regulation of biosynthetic process|negative regulation of cell death|nucleobase-containing compound metabolic process|regulation of ossification|ossification|cell death|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of osteoblast differentiation|negative regulation of gene expression|negative regulation of programmed cell death|regulation of RNA metabolic process|regulation of osteoblast differentiation|osteoblast differentiation|programmed cell death|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|regulation of programmed cell death|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|regulation of apoptotic process|negative regulation of apoptotic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription K09069 twist[-] hsa05205 Proteoglycans in cancer - Homo sapiens (human) 2:238848032-238910543 76 102 171 222 271 258 2.86262823634512 3.49164260493349 5.80710677521096 7.49206626796219 8.37504498271263 9.10747487218494 4.05379253882986 8.32486204095325 -1.03815410632976 0.000573286789731674 0.00364612352378555 DOWN ENSG00000105270 CLIP3 CAP-Gly domain containing linker protein 3 [Source:HGNC Symbol;Acc:HGNC:24314] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0033218|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0009058|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0060341|GO:0097001|GO:0006810|GO:0051130|GO:0010941|GO:0060627|GO:0031325|GO:0051128|GO:0022607|GO:0010942|GO:0045807|GO:0043231|GO:0005737|GO:0032886|GO:0032880|GO:0032403|GO:0009966|GO:0045184|GO:0010828|GO:0010646|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0090004|GO:0008092|GO:0008219|GO:0051861|GO:0044091|GO:0010008|GO:0046625|GO:0048869|GO:0044249|GO:0007017|GO:0019538|GO:0043254|GO:0010033|GO:0098857|GO:0031323|GO:0010256|GO:0005794|GO:0005768|GO:0006996|GO:0016192|GO:0015631|GO:0032268|GO:0005829|GO:0031333|GO:0034645|GO:0090150|GO:0005802|GO:0007166|GO:0001959|GO:0043412|GO:0007010|GO:0034097|GO:0005769|GO:0070507|GO:0072321|GO:0015031|GO:0008017|GO:0007009|GO:0036211|GO:0070201|GO:0055037|GO:0042157|GO:0072657|GO:0030100|GO:0051247|GO:0006461|GO:0031901|GO:0034613|GO:0032270|GO:0012501|GO:0006796|GO:1903078|GO:0005795|GO:0033043|GO:0044267|GO:0051174|GO:0071310|GO:0043208|GO:0000139|GO:0051246|GO:0009059|GO:0030154|GO:0045121|GO:0043068|GO:1903827|GO:0008643|GO:0000226|GO:0043067|GO:0035594|GO:0010827|GO:0055038|GO:0090003|GO:0045444|GO:0019221|GO:0031401|GO:0034622|GO:0043065|GO:0010803|GO:0031113|GO:0072659|GO:0090002|GO:0043623|GO:0016310|GO:0031110|GO:0051494|GO:0051493|GO:0032272|GO:0031109|GO:0042158|GO:0042981|GO:0071345|GO:1903076|GO:0034612|GO:0006897|GO:0006464|GO:1990778|GO:0032588|GO:0006915|GO:0051258|GO:0008645|GO:0006468|GO:0031111|GO:0071356|GO:0042325|GO:0001932|GO:0018193|GO:0033209|GO:0031115|GO:0001934|GO:0046785|GO:0006497|GO:0042327|GO:0018345|GO:0015758|GO:0018230 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|amide binding|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|biosynthetic process|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|regulation of cellular localization|ceramide binding|transport|positive regulation of cellular component organization|regulation of cell death|regulation of vesicle-mediated transport|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of cell death|positive regulation of endocytosis|intracellular membrane-bounded organelle|cytoplasm|regulation of microtubule-based process|regulation of protein localization|protein complex binding|regulation of signal transduction|establishment of protein localization|positive regulation of glucose transport|regulation of cell communication|protein localization|cell communication|membrane organization|signal transduction|positive regulation of establishment of protein localization to plasma membrane|cytoskeletal protein binding|cell death|glycolipid binding|membrane biogenesis|endosome membrane|sphingolipid binding|cellular developmental process|cellular biosynthetic process|microtubule-based process|protein metabolic process|regulation of protein complex assembly|response to organic substance|membrane microdomain|regulation of cellular metabolic process|endomembrane system organization|Golgi apparatus|endosome|organelle organization|vesicle-mediated transport|tubulin binding|regulation of cellular protein metabolic process|cytosol|negative regulation of protein complex assembly|cellular macromolecule biosynthetic process|establishment of protein localization to membrane|trans-Golgi network|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|macromolecule modification|cytoskeleton organization|response to cytokine|early endosome|regulation of microtubule cytoskeleton organization|chaperone-mediated protein transport|protein transport|microtubule binding|plasma membrane organization|protein modification process|regulation of establishment of protein localization|recycling endosome|lipoprotein metabolic process|protein localization to membrane|regulation of endocytosis|positive regulation of protein metabolic process|protein complex assembly|early endosome membrane|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|positive regulation of protein localization to plasma membrane|Golgi stack|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|glycosphingolipid binding|Golgi membrane|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|membrane raft|positive regulation of programmed cell death|regulation of cellular protein localization|carbohydrate transport|microtubule cytoskeleton organization|regulation of programmed cell death|ganglioside binding|regulation of glucose transport|recycling endosome membrane|regulation of establishment of protein localization to plasma membrane|fat cell differentiation|cytokine-mediated signaling pathway|positive regulation of protein modification process|cellular macromolecular complex assembly|positive regulation of apoptotic process|regulation of tumor necrosis factor-mediated signaling pathway|regulation of microtubule polymerization|protein localization to plasma membrane|establishment of protein localization to plasma membrane|cellular protein complex assembly|phosphorylation|regulation of microtubule polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|microtubule polymerization or depolymerization|lipoprotein biosynthetic process|regulation of apoptotic process|cellular response to cytokine stimulus|regulation of protein localization to plasma membrane|response to tumor necrosis factor|endocytosis|cellular protein modification process|protein localization to cell periphery|trans-Golgi network membrane|apoptotic process|protein polymerization|hexose transport|protein phosphorylation|negative regulation of microtubule polymerization or depolymerization|cellular response to tumor necrosis factor|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|tumor necrosis factor-mediated signaling pathway|negative regulation of microtubule polymerization|positive regulation of protein phosphorylation|microtubule polymerization|protein lipidation|positive regulation of phosphorylation|protein palmitoylation|glucose transport|peptidyl-L-cysteine S-palmitoylation - - - - 19:36014660-36033343 69 49 100 41 27 34 0.905705651650497 0.584544113292313 1.18346106939393 0.482189419105985 0.290779307587737 0.41825893669401 0.891236944778913 0.397075887795911 1.16639428179687 0.000573574938890577 0.00364717917479005 UP ENSG00000230756 RHOQP3 ras homolog family member Q pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:37837] - - - - - - 2:130212870-130213490 4 9 7 23 22 22 0.455610711421353 0.931749023139284 0.718861497262682 2.34738736046888 2.05614801081378 2.34862793649115 0.702073743941106 2.25072110259127 -1.6806928163427 0.000577588353197483 0.00366957282322998 DOWN ENSG00000251191 LINC00589 long intergenic non-protein coding RNA 589 [Source:HGNC Symbol;Acc:HGNC:32299] - - - - - - 8:29673922-29748109 5 1 6 15 18 17 0.170540475031473 0.0310114400853131 0.184507382825594 0.458380294115959 0.50369967489242 0.543393782508202 0.12868643264746 0.50182458383886 -1.96332318964556 0.000580101855692723 0.00368397379277825 DOWN ENSG00000213551 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 [Source:HGNC Symbol;Acc:HGNC:19123] GO:0007610|GO:0005623|GO:0016020|GO:0005576|GO:0008152|GO:0005488|GO:0043229|GO:0043227|GO:0071944|GO:0009893|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0043231|GO:0005737|GO:0043085|GO:0035176|GO:0050790|GO:0031072|GO:0051345|GO:0005634|GO:0032781|GO:0043462 behavior|cell|membrane|extracellular region|metabolic process|binding|intracellular organelle|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|extracellular space|intracellular|protein binding|plasma membrane|regulation of metabolic process|intracellular membrane-bounded organelle|cytoplasm|positive regulation of catalytic activity|social behavior|regulation of catalytic activity|heat shock protein binding|positive regulation of hydrolase activity|nucleus|positive regulation of ATPase activity|regulation of ATPase activity - - - - 10:73183362-73248862 549 746 601 1558 1745 777 8.27675793577095 10.2213103581205 8.16914778322584 21.0451905827839 21.5849584143856 10.9783699274348 8.88907202570576 17.8695063082014 -1.00739505476876 0.000580419355260925 0.0036852061743853 DOWN ENSG00000156009 MAGEA8 MAGE family member A8 [Source:HGNC Symbol;Acc:HGNC:6806] GO:0005488|GO:0005515 binding|protein binding - - - - X:149881141-149885835 0 0 1 4 4 12 0 0 0.012820731661272 0.0509902273586764 0.046688790756143 0.159995869123696 0.004273577220424 0.0858916290795051 -4.32900143828242 0.000585010349474801 0.00371067923468786 DOWN ENSG00000183128 CALHM3 calcium homeostasis modulator 3 [Source:HGNC Symbol;Acc:HGNC:23458] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0034220|GO:0098655|GO:0005216|GO:0006812|GO:0008324|GO:0005261 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|plasma membrane|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|ion channel activity|cation transport|cation transmembrane transporter activity|cation channel activity - - - - 10:103472804-103479240 89 120 139 191 250 289 3.81088697134185 4.66977981203895 5.36617167572948 7.32767922489536 8.78300834770177 11.5974443000449 4.61561281970343 9.23604395754734 -1.00075283071035 0.000585052829023774 0.00371067923468786 DOWN ENSG00000281332 LINC00997 long intergenic non-protein coding RNA 997 [Source:HGNC Symbol;Acc:HGNC:48952] - - - - - - 7:32760279-32762924 82 58 104 37 45 44 2.19214558032696 1.40916988684279 2.50669582864588 0.886241636105373 0.987052507810328 1.10239054435813 2.03600376527188 0.991894896091277 1.03748106756306 0.000584886370752755 0.00371067923468786 UP ENSG00000118420 UBE3D ubiquitin protein ligase E3D [Source:HGNC Symbol;Acc:HGNC:21381] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0071704|GO:0044237|GO:0016874|GO:0005622|GO:0005737|GO:0019538|GO:0043412|GO:0036211|GO:0044267|GO:0006464|GO:0032446|GO:0016567 cell|cellular process|metabolic process|catalytic activity|organic substance metabolic process|cellular metabolic process|ligase activity|intracellular|cytoplasm|protein metabolic process|macromolecule modification|protein modification process|cellular protein metabolic process|cellular protein modification process|protein modification by small protein conjugation|protein ubiquitination - - - - 6:82892398-83065841 30 32 61 90 106 90 0.255517537554949 0.24770543847444 0.468436008340628 0.686825331725345 0.740762015880846 0.718421766194949 0.323886328123339 0.715336371267047 -1.14313422676477 0.000587449532066629 0.00372271669079116 DOWN ENSG00000274180 NATD1 N-acetyltransferase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30770] GO:0005488|GO:0005515 binding|protein binding - - - - 17:21238870-21253410 212 262 446 48 52 207 3.04121764661303 3.415792566359 5.76846014168386 0.61694437004745 0.612048096676089 2.78297337156708 4.0751567848853 1.33732194609687 1.60750874490814 0.000588503564073954 0.00372781357985653 UP ENSG00000198682 PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [Source:HGNC Symbol;Acc:HGNC:8604] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0009058|GO:0005622|GO:0016740|GO:0048856|GO:0050817|GO:0006725|GO:1901360|GO:0006082|GO:0007275|GO:0009410|GO:0048513|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0046483|GO:0005737|GO:0009611|GO:0005975|GO:0006139|GO:0055086|GO:0006805|GO:0060348|GO:0000166|GO:0044249|GO:0050878|GO:0006790|GO:0005829|GO:0035639|GO:0019693|GO:0050427|GO:0007596|GO:0001883|GO:0009116|GO:0042060|GO:0032549|GO:0000103|GO:0071466|GO:0007599|GO:0016301|GO:0006796|GO:1901137|GO:0017076|GO:0001501|GO:0016779|GO:0016773|GO:0004020|GO:0009259|GO:0009117|GO:0005524|GO:0046390|GO:0030554|GO:0016310|GO:0006163|GO:0030203|GO:0050428|GO:0009165|GO:0042278|GO:0006164|GO:0004781|GO:0009152 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|biosynthetic process|intracellular|transferase activity|anatomical structure development|coagulation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|response to xenobiotic stimulus|animal organ development|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|cytoplasm|response to wounding|carbohydrate metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|xenobiotic metabolic process|bone development|nucleotide binding|cellular biosynthetic process|regulation of body fluid levels|sulfur compound metabolic process|cytosol|purine ribonucleoside triphosphate binding|ribose phosphate metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|blood coagulation|purine nucleoside binding|nucleoside metabolic process|wound healing|ribonucleoside binding|sulfate assimilation|cellular response to xenobiotic stimulus|hemostasis|kinase activity|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|purine nucleotide binding|skeletal system development|nucleotidyltransferase activity|phosphotransferase activity, alcohol group as acceptor|adenylylsulfate kinase activity|ribonucleotide metabolic process|nucleotide metabolic process|ATP binding|ribose phosphate biosynthetic process|adenyl nucleotide binding|phosphorylation|purine nucleotide metabolic process|glycosaminoglycan metabolic process|3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|nucleotide biosynthetic process|purine nucleoside metabolic process|purine nucleotide biosynthetic process|sulfate adenylyltransferase (ATP) activity|purine ribonucleotide biosynthetic process K13811 3'-phosphoadenosine 5'-phosphosulfate synthase[2.7.1.25] hsa01100|hsa00230|hsa00450|hsa00920 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Selenocompound metabolism - Homo sapiens (human)|Sulfur metabolism - Homo sapiens (human) 10:87659613-87747705 39 46 59 84 116 125 0.434237107886319 0.465483377244954 0.592287886868486 0.837997680519122 1.05972427708771 1.30438783621451 0.49733612399992 1.06736993127378 -1.10176714486882 0.000592957237216694 0.00375300964573771 DOWN ENSG00000233822 HIST1H2BN histone cluster 1, H2bn [Source:HGNC Symbol;Acc:HGNC:4749] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0097159|GO:0043229|GO:0000785|GO:0016043|GO:0043227|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0003676|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0046983|GO:0000790|GO:0070062|GO:0000786|GO:0006996|GO:0051276|GO:0003677|GO:0046982|GO:0006325|GO:0000788|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0005634|GO:0006334|GO:0034622|GO:0034728|GO:0006333|GO:0065004|GO:0031497|GO:0071103|GO:0006323 macromolecular complex|cell|cellular process|extracellular region|binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|chromatin|cellular component organization|membrane-bounded organelle|protein-DNA complex|intracellular|protein binding|protein complex|nucleic acid binding|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|nuclear chromatin|extracellular exosome|nucleosome|organelle organization|chromosome organization|DNA binding|protein heterodimerization activity|chromatin organization|nuclear nucleosome|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|nucleus|nucleosome assembly|cellular macromolecular complex assembly|nucleosome organization|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|DNA conformation change|DNA packaging K11252 histone H2B[-] hsa05203|hsa05034|hsa05322 Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 6:27837760-27865798 17 5 17 36 41 46 0.174048878360581 0.0465287212408767 0.156924809634862 0.330242665455783 0.344412526657642 0.441380354773056 0.125834136412107 0.37201184896216 -1.56382522230772 0.000601169256369405 0.00380078504439903 DOWN ENSG00000241020 RP11-727A23.1 - - - - - - - 11:83213005-83213404 2 2 3 24 11 8 0.353667814740825 0.321436510395347 0.478251954533179 3.80269086087997 1.59601224170803 1.32589119943037 0.384452093223117 2.24153143400612 -2.54360899157924 0.000603047547110195 0.00381104603544195 DOWN ENSG00000164241 C5orf63 chromosome 5 open reading frame 63 [Source:HGNC Symbol;Acc:HGNC:40051] GO:0005623|GO:0008152|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0055114|GO:0005739 cell|metabolic process|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|oxidation-reduction process|mitochondrion - - - - 5:127042558-127073492 21 43 48 66 104 113 0.136811955547505 0.254594254379983 0.281937718501428 0.385246641704458 0.555899816547307 0.689925027209188 0.224447976142972 0.543690495153651 -1.2764045195624 0.000606948497378457 0.0038332643200204 DOWN ENSG00000249437 NAIP NLR family, apoptosis inhibitory protein [Source:HGNC Symbol;Acc:HGNC:7634] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0044297|GO:0043227|GO:0071944|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0016740|GO:0048856|GO:0019222|GO:0004857|GO:0045087|GO:0043025|GO:0016323|GO:0010941|GO:0007275|GO:0043168|GO:0006952|GO:0001882|GO:0031982|GO:0043169|GO:0010243|GO:0005737|GO:0009611|GO:0043005|GO:0009966|GO:0043204|GO:0036477|GO:0060548|GO:0010646|GO:0007154|GO:0044092|GO:0007165|GO:0070062|GO:0008219|GO:0019787|GO:0050790|GO:0000166|GO:0043086|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0032268|GO:1901215|GO:0046872|GO:0035639|GO:0043412|GO:0004842|GO:0030414|GO:0043069|GO:0048678|GO:0001883|GO:0070997|GO:0043200|GO:0036211|GO:0032269|GO:0006954|GO:0032549|GO:0051346|GO:0006508|GO:1901214|GO:0012501|GO:0044267|GO:0007399|GO:0017076|GO:0051246|GO:0043067|GO:0004866|GO:0010466|GO:0043523|GO:0005524|GO:0030162|GO:0030554|GO:0052547|GO:0042981|GO:0045861|GO:0043066|GO:0051402|GO:0043524|GO:0006464|GO:0006915|GO:0004869|GO:0043281|GO:0010951|GO:0043154|GO:0052548|GO:0032446|GO:2000117|GO:2000116|GO:0016567 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|cell body|membrane-bounded organelle|cell periphery|enzyme regulator activity|intracellular|protein binding|plasma membrane|transferase activity|anatomical structure development|regulation of metabolic process|enzyme inhibitor activity|innate immune response|neuronal cell body|basolateral plasma membrane|regulation of cell death|multicellular organism development|anion binding|defense response|nucleoside binding|vesicle|cation binding|response to organonitrogen compound|cytoplasm|response to wounding|neuron projection|regulation of signal transduction|perikaryon|somatodendritic compartment|negative regulation of cell death|regulation of cell communication|cell communication|negative regulation of molecular function|signal transduction|extracellular exosome|cell death|ubiquitin-like protein transferase activity|regulation of catalytic activity|nucleotide binding|negative regulation of catalytic activity|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|negative regulation of neuron death|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|ubiquitin-protein transferase activity|peptidase inhibitor activity|negative regulation of programmed cell death|response to axon injury|purine nucleoside binding|neuron death|response to amino acid|protein modification process|negative regulation of cellular protein metabolic process|inflammatory response|ribonucleoside binding|negative regulation of hydrolase activity|proteolysis|regulation of neuron death|programmed cell death|cellular protein metabolic process|nervous system development|purine nucleotide binding|regulation of protein metabolic process|regulation of programmed cell death|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of neuron apoptotic process|ATP binding|regulation of proteolysis|adenyl nucleotide binding|regulation of peptidase activity|regulation of apoptotic process|negative regulation of proteolysis|negative regulation of apoptotic process|neuron apoptotic process|negative regulation of neuron apoptotic process|cellular protein modification process|apoptotic process|cysteine-type endopeptidase inhibitor activity|regulation of cysteine-type endopeptidase activity involved in apoptotic process|negative regulation of endopeptidase activity|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of endopeptidase activity|protein modification by small protein conjugation|negative regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|protein ubiquitination - - - - 5:70968483-71025114 2 4 4 13 14 17 0.0102661194409528 0.0186610455962466 0.0185132226405554 0.0597909306809019 0.0589649098757137 0.0817851019537018 0.0158134625592516 0.0668469808367725 -2.07970910329127 0.000611327623336243 0.00385765691546823 DOWN ENSG00000173821 RNF213 ring finger protein 213 [Source:HGNC Symbol;Acc:HGNC:14539] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0016817|GO:0043231|GO:0043169|GO:0005737|GO:0019787|GO:0019538|GO:0005730|GO:0046872|GO:0043412|GO:0004842|GO:0016818|GO:0036211|GO:0031981|GO:0044267|GO:0005634|GO:0046914|GO:0006464|GO:0016462|GO:0017111|GO:0008270|GO:0032446|GO:0016887|GO:0016567|GO:0051865 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|ligase activity|intracellular|protein binding|transferase activity|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cation binding|cytoplasm|ubiquitin-like protein transferase activity|protein metabolic process|nucleolus|metal ion binding|macromolecule modification|ubiquitin-protein transferase activity|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|protein modification process|nuclear lumen|cellular protein metabolic process|nucleus|transition metal ion binding|cellular protein modification process|pyrophosphatase activity|nucleoside-triphosphatase activity|zinc ion binding|protein modification by small protein conjugation|ATPase activity|protein ubiquitination|protein autoubiquitination - - - - 17:80260866-80398786 1542 1880 2803 3260 3461 6442 2.65709132930101 2.94415021452822 4.35471098721598 5.03311954917464 4.89318441979088 10.4033120862723 3.31865084368174 6.77653868507927 -1.02995171190058 0.000614880695567719 0.00387925787943336 DOWN ENSG00000145029 NICN1 nicolin 1 [Source:HGNC Symbol;Acc:HGNC:18317] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0005874|GO:0043231|GO:0005856|GO:0005634|GO:0015630 cell|intracellular organelle|membrane-bounded organelle|intracellular|microtubule|intracellular membrane-bounded organelle|cytoskeleton|nucleus|microtubule cytoskeleton - - - - 3:49422946-49429326 36 28 69 86 118 128 0.317642607962048 0.224528434353742 0.548906756298195 0.679875385998709 0.854246808801047 1.05845492822801 0.363692599537995 0.864192374342589 -1.24863293064783 0.000617690332914393 0.00389369239840082 DOWN ENSG00000197779 ZNF81 zinc finger protein 81 [Source:HGNC Symbol;Acc:HGNC:13156] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:47836902-48002561 48 74 63 122 134 145 0.211324051995377 0.296088899847585 0.250072642886808 0.481247746635069 0.484041915607462 0.598284176543596 0.252495198243257 0.521191279595376 -1.04555699332296 0.000620737722026969 0.00391207598762785 DOWN ENSG00000140807 NKD1 naked cuticle homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:17045] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0040012|GO:0071704|GO:0009056|GO:0043167|GO:0048870|GO:0023051|GO:0045926|GO:0009653|GO:0071944|GO:0040008|GO:0023057|GO:0009893|GO:0008287|GO:0050793|GO:0048589|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0001756|GO:0009888|GO:0007164|GO:0007275|GO:0048513|GO:0061061|GO:0043169|GO:0005737|GO:0007389|GO:0007423|GO:0006928|GO:0009887|GO:0009966|GO:0048729|GO:0000159|GO:0019904|GO:0010646|GO:0007154|GO:0051270|GO:0007165|GO:0009968|GO:0048638|GO:0048640|GO:0048869|GO:2000145|GO:0009967|GO:0019538|GO:0060560|GO:0090245|GO:0030111|GO:0045732|GO:0030178|GO:0046872|GO:0007166|GO:0001654|GO:0002009|GO:0030163|GO:0030165|GO:1901233|GO:0009790|GO:0001736|GO:0090249|GO:2000027|GO:0003002|GO:0051247|GO:0014807|GO:0060429|GO:0042176|GO:0003401|GO:0007399|GO:0051246|GO:0030177|GO:0030154|GO:0045995|GO:0007525|GO:0030182|GO:0016055|GO:0009792|GO:0090090|GO:0060028|GO:0060828|GO:2000052|GO:0005509|GO:0090175|GO:0061053|GO:0009952|GO:0060026|GO:0022008|GO:0035282|GO:0048592|GO:0001738|GO:0035567|GO:0048699|GO:0060070|GO:0001754|GO:1901231|GO:2000095|GO:0043009|GO:2000096|GO:0060071|GO:0038030|GO:0038031 locomotion|developmental process|growth|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|organic substance metabolic process|catabolic process|ion binding|cell motility|regulation of signaling|negative regulation of growth|anatomical structure morphogenesis|cell periphery|regulation of growth|negative regulation of signaling|positive regulation of metabolic process|protein serine/threonine phosphatase complex|regulation of developmental process|developmental growth|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|somitogenesis|tissue development|establishment of tissue polarity|multicellular organism development|animal organ development|muscle structure development|cation binding|cytoplasm|pattern specification process|sensory organ development|movement of cell or subcellular component|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|protein phosphatase type 2A complex|protein domain specific binding|regulation of cell communication|cell communication|regulation of cellular component movement|signal transduction|negative regulation of signal transduction|regulation of developmental growth|negative regulation of developmental growth|cellular developmental process|regulation of cell motility|positive regulation of signal transduction|protein metabolic process|developmental growth involved in morphogenesis|axis elongation involved in somitogenesis|regulation of Wnt signaling pathway|positive regulation of protein catabolic process|negative regulation of Wnt signaling pathway|metal ion binding|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|protein catabolic process|PDZ domain binding|negative regulation of convergent extension involved in axis elongation|embryo development|establishment of planar polarity|regulation of cell motility involved in somitogenic axis elongation|regulation of organ morphogenesis|regionalization|positive regulation of protein metabolic process|regulation of somitogenesis|epithelium development|regulation of protein catabolic process|axis elongation|nervous system development|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|cell differentiation|regulation of embryonic development|somatic muscle development|neuron differentiation|Wnt signaling pathway|embryo development ending in birth or egg hatching|negative regulation of canonical Wnt signaling pathway|convergent extension involved in axis elongation|regulation of canonical Wnt signaling pathway|positive regulation of non-canonical Wnt signaling pathway|calcium ion binding|regulation of establishment of planar polarity|somite development|anterior/posterior pattern specification|convergent extension|neurogenesis|segmentation|eye morphogenesis|morphogenesis of a polarized epithelium|non-canonical Wnt signaling pathway|generation of neurons|canonical Wnt signaling pathway|eye photoreceptor cell differentiation|positive regulation of non-canonical Wnt signaling pathway via JNK cascade|regulation of Wnt signaling pathway, planar cell polarity pathway|chordate embryonic development|positive regulation of Wnt signaling pathway, planar cell polarity pathway|Wnt signaling pathway, planar cell polarity pathway|non-canonical Wnt signaling pathway via MAPK cascade|non-canonical Wnt signaling pathway via JNK cascade K03213 naked cuticle[-] hsa04390|hsa04310 Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human) 16:50548330-50640739 22 29 75 15 11 17 0.16869427054835 0.202098881837494 0.518509894549909 0.103054821679837 0.0692037828382884 0.122167881292359 0.296434348978584 0.0981421619368281 1.59476767045043 0.000622082601507427 0.00391972435318758 UP ENSG00000270696 RP11-342K6.1 - - - - - - - 2:75660462-75662208 52 70 85 153 126 168 2.10552035269106 2.57590792532047 3.10301519681529 5.55061121847708 4.18593481556154 6.37516631852586 2.59481449160894 5.37057078418816 -1.04944402480392 0.000627054082457231 0.00394808951289698 DOWN ENSG00000135763 URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:28967] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0016234|GO:0005730|GO:0016235|GO:0031981|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|inclusion body|nucleolus|aggresome|nuclear lumen|nucleus - - - - 1:229626234-229660199 262 331 270 701 807 372 3.03025750241251 3.47925562668899 2.81550143895299 7.26430197832048 7.6580769181072 4.03227600024997 3.1083381893515 6.31821829889255 -1.02337430556914 0.000627870378213149 0.00395202240589824 DOWN ENSG00000181264 TMEM136 transmembrane protein 136 [Source:HGNC Symbol;Acc:HGNC:28280] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 11:120325129-120333682 86 121 77 33 51 58 0.647440555272221 0.827883564945219 0.522648986932347 0.222591736771762 0.315021917531443 0.409223802592642 0.665991035716596 0.315612485631949 1.07734847915118 0.000628878131606148 0.00395753114270024 UP ENSG00000121454 LHX4 LIM homeobox 4 [Source:HGNC Symbol;Acc:HGNC:21734] GO:0040011|GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0001890|GO:0006935|GO:0006725|GO:0048468|GO:1901360|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0021517|GO:0046483|GO:0043231|GO:0048608|GO:0043169|GO:0006928|GO:0009887|GO:0060548|GO:0006139|GO:0008219|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0000902|GO:0031175|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0061458|GO:0007417|GO:0043069|GO:0051252|GO:0021510|GO:0000904|GO:0012501|GO:0010467|GO:0032990|GO:0007399|GO:0097485|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0021522|GO:0005634|GO:0043067|GO:0048666|GO:0030182|GO:0007411|GO:0021953|GO:0032774|GO:0043565|GO:2001141|GO:0021515|GO:0061564|GO:0042981|GO:0046914|GO:0043066|GO:0022008|GO:0048667|GO:0048812|GO:0006351|GO:0006915|GO:0006355|GO:0021523|GO:0021526|GO:0007409|GO:0008045|GO:0048699|GO:1903506|GO:0008270 locomotion|developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|placenta development|chemotaxis|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|ventral spinal cord development|heterocycle metabolic process|intracellular membrane-bounded organelle|reproductive structure development|cation binding|movement of cell or subcellular component|organ morphogenesis|negative regulation of cell death|nucleobase-containing compound metabolic process|cell death|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|cell morphogenesis|neuron projection development|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|reproductive system development|central nervous system development|negative regulation of programmed cell death|regulation of RNA metabolic process|spinal cord development|cell morphogenesis involved in differentiation|programmed cell death|gene expression|cell part morphogenesis|nervous system development|neuron projection guidance|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|spinal cord motor neuron differentiation|nucleus|regulation of programmed cell death|neuron development|neuron differentiation|axon guidance|central nervous system neuron differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|cell differentiation in spinal cord|axon development|regulation of apoptotic process|transition metal ion binding|negative regulation of apoptotic process|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|somatic motor neuron differentiation|medial motor column neuron differentiation|axonogenesis|motor neuron axon guidance|generation of neurons|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 1:180230286-180278982 58 58 102 134 179 164 0.60458966015919 0.549464120333927 0.958614951164687 1.2515145559192 1.53092284021975 1.60215179195452 0.704222910552601 1.46152972936449 -1.05337510726994 0.000630933409254455 0.00396879182466972 DOWN ENSG00000198208 RPS6KL1 ribosomal protein S6 kinase like 1 [Source:HGNC Symbol;Acc:HGNC:20222] GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0005737|GO:0030529|GO:0007154|GO:0007165|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0005840|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|cell communication|signal transduction|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|ribosome|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 14:74903954-74923396 105 90 45 34 45 20 0.339724124995484 0.264641503321422 0.131267996950167 0.0985630915437193 0.119459403360295 0.0606438247749698 0.245211208422358 0.092888773226328 1.40044878059498 0.000637058177858273 0.00400478729033078 UP ENSG00000159556 ISL2 ISL LIM homeobox 2 [Source:HGNC Symbol;Acc:HGNC:18524] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0019222|GO:0006935|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0034641|GO:0021517|GO:0046483|GO:0043231|GO:0043169|GO:0006928|GO:0006139|GO:0030030|GO:0048869|GO:0044249|GO:0031323|GO:0050768|GO:0000902|GO:0031175|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0007417|GO:0051252|GO:0021510|GO:0010721|GO:0000904|GO:0001708|GO:0010467|GO:0032990|GO:0007399|GO:0097485|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0021522|GO:0005634|GO:0051960|GO:0045165|GO:0007422|GO:0048666|GO:0030182|GO:0007411|GO:0021953|GO:0021520|GO:0032774|GO:0048934|GO:0043565|GO:2001141|GO:0021524|GO:0021515|GO:0048663|GO:0061564|GO:0048665|GO:0046914|GO:0045665|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0048935|GO:0006351|GO:0006355|GO:0007409|GO:0048699|GO:1903506|GO:0031290|GO:0008270|GO:0045664 locomotion|developmental process|cell|cellular process|metabolic process|response to stimulus|binding|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|regulation of metabolic process|chemotaxis|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|cellular nitrogen compound metabolic process|ventral spinal cord development|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|movement of cell or subcellular component|nucleobase-containing compound metabolic process|cell projection organization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|negative regulation of neurogenesis|cell morphogenesis|neuron projection development|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|central nervous system development|regulation of RNA metabolic process|spinal cord development|negative regulation of cell development|cell morphogenesis involved in differentiation|cell fate specification|gene expression|cell part morphogenesis|nervous system development|neuron projection guidance|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|spinal cord motor neuron differentiation|nucleus|regulation of nervous system development|cell fate commitment|peripheral nervous system development|neuron development|neuron differentiation|axon guidance|central nervous system neuron differentiation|spinal cord motor neuron cell fate specification|RNA biosynthetic process|peripheral nervous system neuron differentiation|sequence-specific DNA binding|regulation of RNA biosynthetic process|visceral motor neuron differentiation|cell differentiation in spinal cord|neuron fate commitment|axon development|neuron fate specification|transition metal ion binding|negative regulation of neuron differentiation|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|peripheral nervous system neuron development|transcription, DNA-templated|regulation of transcription, DNA-templated|axonogenesis|generation of neurons|regulation of nucleic acid-templated transcription|retinal ganglion cell axon guidance|zinc ion binding|regulation of neuron differentiation - - - - 15:76336724-76342476 56 49 95 22 38 35 1.23212389049578 0.979815933602574 1.88452506028101 0.433690400976149 0.685994621033425 0.721705491515316 1.36548829479312 0.61379683784163 1.15358382865917 0.000638867183691444 0.00401531387408934 UP ENSG00000272692 RP11-399K21.14 - - - - - - - 10:75409157-75411842 12 13 18 37 37 41 0.449137045675597 0.442203889780832 0.607410019016319 1.24073829054752 1.13619549155455 1.43813129324786 0.499583651490916 1.27168835844998 -1.3479469935804 0.000640069353417788 0.00402202283244257 DOWN ENSG00000141579 ZNF750 zinc finger protein 750 [Source:HGNC Symbol;Acc:HGNC:25843] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0043169|GO:0000981|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0000982|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010628|GO:0031981|GO:0060429|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0000975|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0008544|GO:0003690|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0044212|GO:0001047|GO:0000976|GO:0001046 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|epithelium development|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulatory region DNA binding|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|epidermis development|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|core promoter binding|transcription regulatory region sequence-specific DNA binding|core promoter sequence-specific DNA binding - - - - 17:82829435-82840578 147 105 288 64 59 111 1.98973033113222 1.29165655242253 3.51465972762674 0.77616653854063 0.655238689964306 1.40808160250324 2.26534887039383 0.946495610336059 1.25906552654809 0.000641116958337842 0.00402691051424741 UP ENSG00000048545 GUCA1A guanylate cyclase activator 1A [Source:HGNC Symbol;Acc:HGNC:4678] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0051606|GO:0050794|GO:0006807|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0030234|GO:0005886|GO:0005929|GO:0031090|GO:0019222|GO:0006725|GO:0009314|GO:1901360|GO:0050877|GO:0034641|GO:0008047|GO:0060170|GO:0044281|GO:0019637|GO:0031325|GO:0046483|GO:0009582|GO:0043169|GO:0001917|GO:0009966|GO:0072372|GO:0097381|GO:0010646|GO:0006139|GO:0043085|GO:0055086|GO:0007154|GO:0001750|GO:0007165|GO:0050790|GO:0031253|GO:0044249|GO:0031323|GO:0007186|GO:0046872|GO:0051349|GO:0009583|GO:0019693|GO:0008277|GO:0030249|GO:0030250|GO:0031279|GO:0007602|GO:0007600|GO:0022400|GO:0071478|GO:0006796|GO:1901137|GO:0051174|GO:0031281|GO:0031328|GO:0009416|GO:0031513|GO:0050953|GO:0009259|GO:0009117|GO:0046390|GO:0016056|GO:0008048|GO:0005509|GO:0031284|GO:0009584|GO:0071482|GO:0006163|GO:0007603|GO:0009165|GO:0031282|GO:0006164|GO:0030801|GO:0009187|GO:0007601|GO:0030802|GO:0009190|GO:0030826|GO:0046068|GO:0030828|GO:0009152|GO:0030823|GO:0052652|GO:0030825|GO:0006182 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|detection of stimulus|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|enzyme regulator activity|plasma membrane|cilium|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|response to radiation|organic cyclic compound metabolic process|neurological system process|cellular nitrogen compound metabolic process|enzyme activator activity|ciliary membrane|small molecule metabolic process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|detection of abiotic stimulus|cation binding|photoreceptor inner segment|regulation of signal transduction|primary cilium|photoreceptor disc membrane|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|cell communication|photoreceptor outer segment|signal transduction|regulation of catalytic activity|cell projection membrane|cellular biosynthetic process|regulation of cellular metabolic process|G-protein coupled receptor signaling pathway|metal ion binding|positive regulation of lyase activity|detection of light stimulus|ribose phosphate metabolic process|regulation of G-protein coupled receptor protein signaling pathway|guanylate cyclase regulator activity|guanylate cyclase activator activity|regulation of cyclase activity|phototransduction|sensory perception|regulation of rhodopsin mediated signaling pathway|cellular response to radiation|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|positive regulation of cyclase activity|positive regulation of cellular biosynthetic process|response to light stimulus|nonmotile primary cilium|sensory perception of light stimulus|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|rhodopsin mediated signaling pathway|calcium sensitive guanylate cyclase activator activity|calcium ion binding|positive regulation of guanylate cyclase activity|detection of visible light|cellular response to light stimulus|purine nucleotide metabolic process|phototransduction, visible light|nucleotide biosynthetic process|regulation of guanylate cyclase activity|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|cyclic nucleotide metabolic process|visual perception|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|regulation of cGMP biosynthetic process|cGMP metabolic process|positive regulation of cGMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cGMP metabolic process|cyclic purine nucleotide metabolic process|positive regulation of cGMP metabolic process|cGMP biosynthetic process K08328 guanylate cyclase activator 1[-] hsa04744 Phototransduction - Homo sapiens (human) 6:42155406-42180056 6 2 4 0 0 0 0.0837579194176022 0.0253748972090268 0.0503477813275812 0 0 0 0.0531601993180701 0 Inf 0.000643338519684218 0.00403916470381759 UP ENSG00000177098 SCN4B sodium channel, voltage gated, type IV beta subunit [Source:HGNC Symbol;Acc:HGNC:10592] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0022857|GO:0050794|GO:0051050|GO:0005911|GO:0071944|GO:0031224|GO:0016247|GO:0005515|GO:0005886|GO:0043234|GO:0042391|GO:0044325|GO:0006810|GO:0098797|GO:0044291|GO:0043270|GO:0005887|GO:0003012|GO:0007267|GO:0006928|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0017080|GO:0002027|GO:0016021|GO:0030029|GO:0003013|GO:0086009|GO:0006936|GO:0086019|GO:0051899|GO:0061337|GO:0001518|GO:0030048|GO:0014704|GO:0001508|GO:0086091|GO:0015267|GO:0006811|GO:0015075|GO:0034765|GO:0034702|GO:0043269|GO:0010765|GO:0060306|GO:0008015|GO:0022898|GO:0086065|GO:0034220|GO:0006941|GO:0008016|GO:0098655|GO:0070252|GO:0086001|GO:0005216|GO:0086010|GO:0060047|GO:0034703|GO:0006812|GO:0032412|GO:0086067|GO:0008324|GO:0086003|GO:0060307|GO:0005244|GO:0086002|GO:0060048|GO:0034706|GO:0022890|GO:0002028|GO:1902305|GO:0030001|GO:2000649|GO:0005261|GO:0086012|GO:0086016|GO:0015672|GO:0005272|GO:0035725|GO:0022843|GO:0006814|GO:0015077|GO:0046873|GO:0005248|GO:0015081|GO:0086006 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|cell junction|binding|transmembrane transporter activity|regulation of cellular process|positive regulation of transport|cell-cell junction|cell periphery|intrinsic component of membrane|channel regulator activity|protein binding|plasma membrane|protein complex|regulation of membrane potential|ion channel binding|transport|plasma membrane protein complex|cell-cell contact zone|positive regulation of ion transport|integral component of plasma membrane|muscle system process|cell-cell signaling|movement of cell or subcellular component|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|sodium channel regulator activity|regulation of heart rate|integral component of membrane|actin filament-based process|circulatory system process|membrane repolarization|muscle contraction|cell-cell signaling involved in cardiac conduction|membrane depolarization|cardiac conduction|voltage-gated sodium channel complex|actin filament-based movement|intercalated disc|action potential|regulation of heart rate by cardiac conduction|channel activity|ion transport|ion transmembrane transporter activity|regulation of ion transmembrane transport|ion channel complex|regulation of ion transport|positive regulation of sodium ion transport|regulation of membrane repolarization|blood circulation|regulation of transmembrane transporter activity|cell communication involved in cardiac conduction|ion transmembrane transport|striated muscle contraction|regulation of heart contraction|cation transmembrane transport|actin-mediated cell contraction|cardiac muscle cell action potential|ion channel activity|membrane depolarization during action potential|heart contraction|cation channel complex|cation transport|regulation of ion transmembrane transporter activity|AV node cell to bundle of His cell communication|cation transmembrane transporter activity|cardiac muscle cell contraction|regulation of ventricular cardiac muscle cell membrane repolarization|voltage-gated ion channel activity|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|sodium channel complex|inorganic cation transmembrane transporter activity|regulation of sodium ion transport|regulation of sodium ion transmembrane transport|metal ion transport|regulation of sodium ion transmembrane transporter activity|cation channel activity|membrane depolarization during cardiac muscle cell action potential|AV node cell action potential|monovalent inorganic cation transport|sodium channel activity|sodium ion transmembrane transport|voltage-gated cation channel activity|sodium ion transport|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|voltage-gated sodium channel activity|sodium ion transmembrane transporter activity|voltage-gated sodium channel activity involved in cardiac muscle cell action potential K04848 voltage-gated sodium channel type IV beta[-] hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) 11:118133377-118152888 0 0 0 4 4 5 0 0 0 0.0226521989302483 0.0207413033988155 0.0296193033987663 0 0.0243376019092767 -Inf 0.000644448441615746 0.00404475428248791 DOWN ENSG00000235475 LINC01372 long intergenic non-protein coding RNA 1372 [Source:HGNC Symbol;Acc:HGNC:50623] - - - - - - 7:67335976-67340024 0 0 0 4 4 5 0 0 0 0.518452782059998 0.474717111737307 0.677912563678921 0 0.557027485825409 -Inf 0.000644513737402215 0.00404475428248791 DOWN ENSG00000214300 SPDYE3 speedy/RINGO cell cycle regulator family member E3 [Source:HGNC Symbol;Acc:HGNC:35462] GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0071704|GO:0044237|GO:0005515|GO:0019222|GO:0019899|GO:0050790|GO:0019538|GO:0031323|GO:0032268|GO:0043412|GO:0036211|GO:0019900|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0016310|GO:0019901|GO:0006464|GO:0043549|GO:0045859|GO:0006468|GO:0042325|GO:0001932 cellular process|metabolic process|binding|regulation of cellular process|organic substance metabolic process|cellular metabolic process|protein binding|regulation of metabolic process|enzyme binding|regulation of catalytic activity|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|protein modification process|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|phosphorylation|protein kinase binding|cellular protein modification process|regulation of kinase activity|regulation of protein kinase activity|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation K08694 speedy[-] hsa04114|hsa04914 Oocyte meiosis - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human) 7:100307702-100322196 84 204 76 49 66 37 1.26449975131761 2.79093628945098 1.03149573420786 0.660899255249379 0.81518315020156 0.521995030001527 1.69564392499215 0.666025811817489 1.34818324932892 0.000645740981885719 0.00404998976328072 UP ENSG00000232303 DFFBP1 DNA fragmentation factor, 40kDa, beta polypeptide pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:49815] - - - - - - 9:32566148-32567126 22 26 12 4 7 8 1.5895859507748 1.70732365072095 0.781753446333567 0.258961604113727 0.414982869298945 0.541732870043051 1.35955434927644 0.405225781151908 1.74633595652926 0.000646134942558039 0.00405160944657167 UP ENSG00000223797 ENTPD3-AS1 ENTPD3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:26710] - - - - - - 3:40313802-40453329 17 11 14 42 34 43 0.324913185785802 0.191080990955859 0.241257154270194 0.71924660666712 0.533174254967302 0.770234972978624 0.252417110337285 0.674218611537682 -1.41740674478689 0.000652401909881448 0.00408741210741487 DOWN ENSG00000276612 CH507-9B2.4 - - - - - - - 21:5116343-5133805 0 0 0 0 0 81 0 0 0 0 0 3.35825549912394 0 1.11941849970798 -Inf 0.000652603023680745 0.00408741210741487 DOWN ENSG00000130203 APOE apolipoprotein E [Source:HGNC Symbol;Acc:HGNC:613] GO:0016209|GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0040013|GO:0042995|GO:0033218|GO:0097159|GO:0009892|GO:0048523|GO:0032994|GO:0051606|GO:0044877|GO:0008283|GO:0034358|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0044297|GO:0009653|GO:0097006|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0005615|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0072562|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0042802|GO:0016032|GO:0048514|GO:0042127|GO:0044255|GO:0050817|GO:0098869|GO:0008201|GO:0050804|GO:0042277|GO:0045595|GO:0006725|GO:0048468|GO:0043025|GO:0009314|GO:0032369|GO:0006810|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0009991|GO:0007275|GO:0010632|GO:0051702|GO:0045596|GO:0005496|GO:0032535|GO:0005102|GO:0016358|GO:0034641|GO:0043168|GO:0008047|GO:0044281|GO:0006952|GO:0005543|GO:0043270|GO:0031982|GO:0048524|GO:0019637|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0022607|GO:0010942|GO:0034364|GO:0009582|GO:0051668|GO:0050803|GO:0045597|GO:0043231|GO:0043178|GO:0090083|GO:0043169|GO:0051651|GO:0005737|GO:0007267|GO:0009611|GO:0097242|GO:0006928|GO:0042592|GO:0050819|GO:0001775|GO:0043005|GO:0009966|GO:0046983|GO:0050673|GO:0045184|GO:0009890|GO:0019725|GO:0036477|GO:0005319|GO:0006979|GO:0060548|GO:0090261|GO:0010646|GO:0006139|GO:0043085|GO:0055086|GO:0008104|GO:0050865|GO:0007154|GO:0044092|GO:0060996|GO:0002021|GO:0061024|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0048588|GO:0005783|GO:0034369|GO:0009968|GO:0070062|GO:0048638|GO:0050808|GO:0051649|GO:0008092|GO:0008219|GO:0051271|GO:0008285|GO:0050790|GO:0030030|GO:0031983|GO:0045833|GO:0043086|GO:0048869|GO:2000145|GO:0043954|GO:0034381|GO:0044249|GO:0010633|GO:0010876|GO:0042627|GO:0034377|GO:0034362|GO:0019538|GO:0023014|GO:0005539|GO:0050792|GO:0001558|GO:0031324|GO:0031323|GO:2000146|GO:0050878|GO:0003013|GO:0032370|GO:0043271|GO:0005794|GO:0005768|GO:0006996|GO:1900221|GO:0009636|GO:0060560|GO:0050768|GO:0000165|GO:1901630|GO:0016192|GO:0043113|GO:0032268|GO:0000902|GO:0060998|GO:0045732|GO:0031175|GO:0007186|GO:2000171|GO:0031344|GO:0035150|GO:0015248|GO:0045940|GO:0010468|GO:0010872|GO:0090132|GO:0030193|GO:0034645|GO:0030168|GO:0032801|GO:1901215|GO:0046486|GO:0006518|GO:0048167|GO:0046872|GO:0031102|GO:0001944|GO:0043412|GO:0009583|GO:0007010|GO:0050807|GO:0072358|GO:0050773|GO:0030163|GO:0031410|GO:0034370|GO:1903001|GO:0050727|GO:0019693|GO:0016042|GO:1901631|GO:0010720|GO:0010544|GO:0005769|GO:0043069|GO:0019068|GO:0097061|GO:0010873|GO:0048878|GO:0006720|GO:0034447|GO:0007596|GO:0006066|GO:0044242|GO:0071813|GO:2001140|GO:1901216|GO:0034380|GO:0034374|GO:0070997|GO:0010721|GO:0015031|GO:0044265|GO:0070325|GO:0046889|GO:0031346|GO:0044794|GO:0000904|GO:1901627|GO:0097090|GO:0030334|GO:0051055|GO:0001935|GO:0001667|GO:0016023|GO:0036211|GO:0032269|GO:0032934|GO:0060840|GO:0042060|GO:0048844|GO:0046907|GO:0006811|GO:0006954|GO:0055082|GO:0048156|GO:0007602|GO:0031345|GO:0034363|GO:0060999|GO:0030195|GO:1903002|GO:0006638|GO:0042157|GO:0072657|GO:0050769|GO:0032368|GO:0050728|GO:0007599|GO:0034384|GO:0030425|GO:0097062|GO:0006869|GO:0008361|GO:0051247|GO:0045939|GO:0006508|GO:0031988|GO:0022604|GO:0050678|GO:0050680|GO:1901214|GO:0051353|GO:0043269|GO:0030336|GO:0034613|GO:0008202|GO:0061045|GO:0051341|GO:0010543|GO:0032270|GO:0012501|GO:0000302|GO:0006796|GO:0043603|GO:0035556|GO:0042982|GO:0060205|GO:1901137|GO:0001941|GO:0044267|GO:0051174|GO:0060228|GO:0042176|GO:0010467|GO:0034375|GO:0017038|GO:0030516|GO:0032990|GO:0072578|GO:2000646|GO:0008610|GO:0007399|GO:0019216|GO:0019058|GO:0061000|GO:1902532|GO:0010594|GO:0046890|GO:0031328|GO:0051246|GO:1901628|GO:0009059|GO:0030154|GO:0048858|GO:1902998|GO:1900006|GO:0030258|GO:1902531|GO:0072359|GO:0031667|GO:0008015|GO:0034361|GO:0010596|GO:0005634|GO:0009416|GO:0042803|GO:0043067|GO:1990138|GO:0051960|GO:0001540|GO:0043112|GO:0048666|GO:0045541|GO:0030182|GO:0032375|GO:0015914|GO:0017127|GO:1902951|GO:0044257|GO:0071682|GO:0006820|GO:0010975|GO:0015711|GO:0032376|GO:1902952|GO:1902430|GO:0048168|GO:0030139|GO:1902995|GO:0009259|GO:0043408|GO:0010769|GO:0042159|GO:0043523|GO:0034382|GO:0009117|GO:0032770|GO:0034372|GO:1903364|GO:0065005|GO:0046390|GO:1990379|GO:0019218|GO:0030162|GO:0046164|GO:1902992|GO:0042987|GO:0045862|GO:0043537|GO:0046461|GO:0043535|GO:0016310|GO:0032805|GO:0033619|GO:0015908|GO:0046911|GO:0061564|GO:0046942|GO:0001936|GO:0006694|GO:0032802|GO:0051044|GO:0009584|GO:0032799|GO:0006706|GO:1902004|GO:0050435|GO:0050810|GO:0016125|GO:0001937|GO:0006163|GO:0042158|GO:1901626|GO:0010631|GO:0015918|GO:0042981|GO:0010894|GO:0044070|GO:0050801|GO:0043066|GO:0043409|GO:1902003|GO:0033673|GO:0051402|GO:0055088|GO:0006639|GO:0007603|GO:0050750|GO:0015485|GO:0045665|GO:0043524|GO:0006897|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0019932|GO:0050767|GO:0097113|GO:0048812|GO:0009165|GO:1902999|GO:0010976|GO:0032803|GO:0010977|GO:0043549|GO:1902991|GO:0097114|GO:0045540|GO:0006915|GO:0006873|GO:0048675|GO:0070326|GO:0050880|GO:0061041|GO:0045666|GO:0006509|GO:0051000|GO:0015718|GO:0090370|GO:0007265|GO:0046578|GO:0006164|GO:0030801|GO:0045859|GO:0010875|GO:0019935|GO:0034205|GO:0006469|GO:0007409|GO:0006468|GO:0043407|GO:0048699|GO:0032374|GO:0042311|GO:0043405|GO:0042325|GO:0046464|GO:0030301|GO:0001932|GO:0055081|GO:0016126|GO:0055089|GO:0090181|GO:0042326|GO:0006898|GO:0050999|GO:0008203|GO:0016101|GO:0009187|GO:0001933|GO:0043542|GO:0050770|GO:0033700|GO:0045664|GO:0030003|GO:0007263|GO:0055092|GO:0006641|GO:0030802|GO:0007268|GO:0009190|GO:0015909|GO:0030826|GO:0046068|GO:0006707|GO:0030828|GO:0007271|GO:0043691|GO:0001523|GO:0055065|GO:0009152|GO:0030823|GO:0071901|GO:0033344|GO:0052652|GO:0006875|GO:0035023|GO:0010874|GO:0019934|GO:0071900|GO:0006695|GO:0007266|GO:0030825|GO:0042632|GO:1902947|GO:0019433|GO:0043534|GO:0034435|GO:0006182|GO:0032489|GO:0032488|GO:0006874|GO:0055074 antioxidant activity|locomotion|developmental process|extracellular matrix|growth|macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|negative regulation of locomotion|cell projection|amide binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|protein-lipid complex|detection of stimulus|macromolecular complex binding|cell proliferation|plasma lipoprotein particle|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|cell body|anatomical structure morphogenesis|regulation of plasma lipoprotein particle levels|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|extracellular space|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|blood microparticle|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|identical protein binding|viral process|blood vessel morphogenesis|regulation of cell proliferation|cellular lipid metabolic process|coagulation|cellular oxidant detoxification|heparin binding|modulation of synaptic transmission|peptide binding|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|neuronal cell body|response to radiation|negative regulation of lipid transport|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|response to extracellular stimulus|multicellular organism development|regulation of epithelial cell migration|interaction with symbiont|negative regulation of cell differentiation|steroid binding|regulation of cellular component size|receptor binding|dendrite development|cellular nitrogen compound metabolic process|anion binding|enzyme activator activity|small molecule metabolic process|defense response|phospholipid binding|positive regulation of ion transport|vesicle|positive regulation of viral process|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|cellular component assembly|positive regulation of cell death|high-density lipoprotein particle|detection of abiotic stimulus|localization within membrane|regulation of synapse structure or activity|positive regulation of cell differentiation|intracellular membrane-bounded organelle|alcohol binding|regulation of inclusion body assembly|cation binding|maintenance of location in cell|cytoplasm|cell-cell signaling|response to wounding|beta-amyloid clearance|movement of cell or subcellular component|homeostatic process|negative regulation of coagulation|cell activation|neuron projection|regulation of signal transduction|protein dimerization activity|epithelial cell proliferation|establishment of protein localization|negative regulation of biosynthetic process|cellular homeostasis|somatodendritic compartment|lipid transporter activity|response to oxidative stress|negative regulation of cell death|positive regulation of inclusion body assembly|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|protein localization|regulation of cell activation|cell communication|negative regulation of molecular function|dendritic spine development|response to dietary excess|membrane organization|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|developmental cell growth|endoplasmic reticulum|plasma lipoprotein particle remodeling|negative regulation of signal transduction|extracellular exosome|regulation of developmental growth|synapse organization|establishment of localization in cell|cytoskeletal protein binding|cell death|negative regulation of cellular component movement|negative regulation of cell proliferation|regulation of catalytic activity|cell projection organization|vesicle lumen|negative regulation of lipid metabolic process|negative regulation of catalytic activity|cellular developmental process|regulation of cell motility|cellular component maintenance|plasma lipoprotein particle clearance|cellular biosynthetic process|negative regulation of epithelial cell migration|lipid localization|chylomicron|plasma lipoprotein particle assembly|low-density lipoprotein particle|protein metabolic process|signal transduction by protein phosphorylation|glycosaminoglycan binding|regulation of viral process|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|negative regulation of cell motility|regulation of body fluid levels|circulatory system process|positive regulation of lipid transport|negative regulation of ion transport|Golgi apparatus|endosome|organelle organization|regulation of beta-amyloid clearance|response to toxic substance|developmental growth involved in morphogenesis|negative regulation of neurogenesis|MAPK cascade|negative regulation of presynaptic membrane organization|vesicle-mediated transport|receptor clustering|regulation of cellular protein metabolic process|cell morphogenesis|regulation of dendritic spine development|positive regulation of protein catabolic process|neuron projection development|G-protein coupled receptor signaling pathway|negative regulation of dendrite development|regulation of cell projection organization|regulation of tube size|sterol transporter activity|positive regulation of steroid metabolic process|regulation of gene expression|regulation of cholesterol esterification|epithelium migration|regulation of blood coagulation|cellular macromolecule biosynthetic process|platelet activation|receptor catabolic process|negative regulation of neuron death|glycerolipid metabolic process|peptide metabolic process|regulation of synaptic plasticity|metal ion binding|neuron projection regeneration|vasculature development|macromolecule modification|detection of light stimulus|cytoskeleton organization|regulation of synapse organization|cardiovascular system development|regulation of dendrite development|protein catabolic process|cytoplasmic vesicle|triglyceride-rich lipoprotein particle remodeling|negative regulation of lipid transport across blood brain barrier|regulation of inflammatory response|ribose phosphate metabolic process|lipid catabolic process|positive regulation of presynaptic membrane organization|positive regulation of cell development|negative regulation of platelet activation|early endosome|negative regulation of programmed cell death|virion assembly|dendritic spine organization|positive regulation of cholesterol esterification|chemical homeostasis|isoprenoid metabolic process|very-low-density lipoprotein particle clearance|blood coagulation|alcohol metabolic process|cellular lipid catabolic process|lipoprotein particle binding|positive regulation of phospholipid transport|positive regulation of neuron death|high-density lipoprotein particle assembly|low-density lipoprotein particle remodeling|neuron death|negative regulation of cell development|protein transport|cellular macromolecule catabolic process|lipoprotein particle receptor binding|positive regulation of lipid biosynthetic process|positive regulation of cell projection organization|positive regulation by host of viral process|cell morphogenesis involved in differentiation|negative regulation of postsynaptic membrane organization|presynaptic membrane organization|regulation of cell migration|negative regulation of lipid biosynthetic process|endothelial cell proliferation|ameboidal-type cell migration|cytoplasmic, membrane-bounded vesicle|protein modification process|negative regulation of cellular protein metabolic process|sterol binding|artery development|wound healing|artery morphogenesis|intracellular transport|ion transport|inflammatory response|cellular chemical homeostasis|tau protein binding|phototransduction|negative regulation of cell projection organization|intermediate-density lipoprotein particle|positive regulation of dendritic spine development|negative regulation of blood coagulation|positive regulation of lipid transport across blood brain barrier|neutral lipid metabolic process|lipoprotein metabolic process|protein localization to membrane|positive regulation of neurogenesis|regulation of lipid transport|negative regulation of inflammatory response|hemostasis|high-density lipoprotein particle clearance|dendrite|dendritic spine maintenance|lipid transport|regulation of cell size|positive regulation of protein metabolic process|negative regulation of steroid metabolic process|proteolysis|membrane-bounded vesicle|regulation of cell morphogenesis|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|regulation of neuron death|positive regulation of oxidoreductase activity|regulation of ion transport|negative regulation of cell migration|cellular protein localization|steroid metabolic process|negative regulation of wound healing|regulation of oxidoreductase activity|regulation of platelet activation|positive regulation of cellular protein metabolic process|programmed cell death|response to reactive oxygen species|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|amyloid precursor protein metabolic process|cytoplasmic membrane-bounded vesicle lumen|carbohydrate derivative biosynthetic process|postsynaptic membrane organization|cellular protein metabolic process|regulation of phosphorus metabolic process|phosphatidylcholine-sterol O-acyltransferase activator activity|regulation of protein catabolic process|gene expression|high-density lipoprotein particle remodeling|protein import|regulation of axon extension|cell part morphogenesis|neurotransmitter-gated ion channel clustering|positive regulation of receptor catabolic process|lipid biosynthetic process|nervous system development|regulation of lipid metabolic process|viral life cycle|negative regulation of dendritic spine development|negative regulation of intracellular signal transduction|regulation of endothelial cell migration|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of postsynaptic membrane organization|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of neurofibrillary tangle assembly|positive regulation of dendrite development|lipid modification|regulation of intracellular signal transduction|circulatory system development|response to nutrient levels|blood circulation|very-low-density lipoprotein particle|negative regulation of endothelial cell migration|nucleus|response to light stimulus|protein homodimerization activity|regulation of programmed cell death|neuron projection extension|regulation of nervous system development|beta-amyloid binding|receptor metabolic process|neuron development|negative regulation of cholesterol biosynthetic process|neuron differentiation|negative regulation of cholesterol transport|phospholipid transport|cholesterol transporter activity|negative regulation of dendritic spine maintenance|cellular protein catabolic process|endocytic vesicle lumen|anion transport|regulation of neuron projection development|organic anion transport|positive regulation of cholesterol transport|positive regulation of dendritic spine maintenance|negative regulation of beta-amyloid formation|regulation of neuronal synaptic plasticity|endocytic vesicle|positive regulation of phospholipid efflux|ribonucleotide metabolic process|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|lipoprotein catabolic process|regulation of neuron apoptotic process|chylomicron remnant clearance|nucleotide metabolic process|positive regulation of monooxygenase activity|very-low-density lipoprotein particle remodeling|positive regulation of cellular protein catabolic process|protein-lipid complex assembly|ribose phosphate biosynthetic process|lipid transport across blood brain barrier|regulation of steroid metabolic process|regulation of proteolysis|alcohol catabolic process|negative regulation of amyloid precursor protein catabolic process|amyloid precursor protein catabolic process|positive regulation of proteolysis|negative regulation of blood vessel endothelial cell migration|neutral lipid catabolic process|regulation of blood vessel endothelial cell migration|phosphorylation|positive regulation of low-density lipoprotein particle receptor catabolic process|membrane protein proteolysis|fatty acid transport|metal chelating activity|axon development|carboxylic acid transport|regulation of endothelial cell proliferation|steroid biosynthetic process|low-density lipoprotein particle receptor catabolic process|positive regulation of membrane protein ectodomain proteolysis|detection of visible light|low-density lipoprotein receptor particle metabolic process|steroid catabolic process|positive regulation of beta-amyloid formation|beta-amyloid metabolic process|regulation of steroid biosynthetic process|sterol metabolic process|negative regulation of endothelial cell proliferation|purine nucleotide metabolic process|lipoprotein biosynthetic process|regulation of postsynaptic membrane organization|epithelial cell migration|sterol transport|regulation of apoptotic process|negative regulation of steroid biosynthetic process|regulation of anion transport|ion homeostasis|negative regulation of apoptotic process|negative regulation of MAPK cascade|regulation of beta-amyloid formation|negative regulation of kinase activity|neuron apoptotic process|lipid homeostasis|acylglycerol metabolic process|phototransduction, visible light|low-density lipoprotein particle receptor binding|cholesterol binding|negative regulation of neuron differentiation|negative regulation of neuron apoptotic process|endocytosis|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|second-messenger-mediated signaling|regulation of neurogenesis|AMPA glutamate receptor clustering|neuron projection morphogenesis|nucleotide biosynthetic process|negative regulation of phospholipid efflux|positive regulation of neuron projection development|regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of neuron projection development|regulation of kinase activity|regulation of amyloid precursor protein catabolic process|NMDA glutamate receptor clustering|regulation of cholesterol biosynthetic process|apoptotic process|cellular ion homeostasis|axon extension|very-low-density lipoprotein particle receptor binding|regulation of blood vessel size|regulation of wound healing|positive regulation of neuron differentiation|membrane protein ectodomain proteolysis|positive regulation of nitric-oxide synthase activity|monocarboxylic acid transport|negative regulation of cholesterol efflux|Ras protein signal transduction|regulation of Ras protein signal transduction|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|regulation of protein kinase activity|positive regulation of cholesterol efflux|cyclic-nucleotide-mediated signaling|beta-amyloid formation|negative regulation of protein kinase activity|axonogenesis|protein phosphorylation|negative regulation of MAP kinase activity|generation of neurons|regulation of cholesterol transport|vasodilation|regulation of MAP kinase activity|regulation of phosphorylation|acylglycerol catabolic process|cholesterol transport|regulation of protein phosphorylation|anion homeostasis|sterol biosynthetic process|fatty acid homeostasis|regulation of cholesterol metabolic process|negative regulation of phosphorylation|receptor-mediated endocytosis|regulation of nitric-oxide synthase activity|cholesterol metabolic process|diterpenoid metabolic process|cyclic nucleotide metabolic process|negative regulation of protein phosphorylation|endothelial cell migration|regulation of axonogenesis|phospholipid efflux|regulation of neuron differentiation|cellular cation homeostasis|nitric oxide mediated signal transduction|sterol homeostasis|triglyceride metabolic process|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|cyclic nucleotide biosynthetic process|long-chain fatty acid transport|regulation of cGMP biosynthetic process|cGMP metabolic process|cholesterol catabolic process|positive regulation of cGMP biosynthetic process|synaptic transmission, cholinergic|reverse cholesterol transport|retinoid metabolic process|metal ion homeostasis|purine ribonucleotide biosynthetic process|regulation of cGMP metabolic process|negative regulation of protein serine/threonine kinase activity|cholesterol efflux|cyclic purine nucleotide metabolic process|cellular metal ion homeostasis|regulation of Rho protein signal transduction|regulation of cholesterol efflux|cGMP-mediated signaling|regulation of protein serine/threonine kinase activity|cholesterol biosynthetic process|Rho protein signal transduction|positive regulation of cGMP metabolic process|cholesterol homeostasis|regulation of tau-protein kinase activity|triglyceride catabolic process|blood vessel endothelial cell migration|cholesterol esterification|cGMP biosynthetic process|regulation of Cdc42 protein signal transduction|Cdc42 protein signal transduction|cellular calcium ion homeostasis|calcium ion homeostasis K04524 apolipoprotein E[-] hsa05010 Alzheimer,s disease - Homo sapiens (human) 19:44905754-44909393 82 78 127 33 12 59 1.50347776193497 1.29974327687077 2.09942430905768 0.542113001220186 0.180525693174589 1.01382908101041 1.63421511595447 0.578822591801728 1.49740476430027 0.000658138542326629 0.00411822847256743 UP ENSG00000224216 RP13-228J13.1 - - - - - - - X:155334858-155351957 1 3 6 10 15 19 0.0395786875965402 0.107881616831699 0.214020308713804 0.35447904142525 0.48691257587902 0.704457603846447 0.120493537714014 0.515283073716906 -2.09640942869138 0.000659257154173348 0.00412436359612136 DOWN ENSG00000251199 RP11-400D2.2 - - - - - - - 4:134255173-134327473 1 2 1 11 7 8 0.0374823588043506 0.0681009555922346 0.0337630708791549 0.369257054856546 0.2151844433494 0.280909152421688 0.0464487950919134 0.288450216875878 -2.63460927023414 0.000661468503357885 0.00413733096569166 DOWN ENSG00000154764 WNT7A wingless-type MMTV integration site family member 7A [Source:HGNC Symbol;Acc:HGNC:12786] GO:0040011|GO:0032502|GO:0031012|GO:0040007|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0005578|GO:0006807|GO:0006950|GO:0001502|GO:0044089|GO:0048018|GO:0044702|GO:0071704|GO:0009986|GO:0044237|GO:0051641|GO:0003006|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0005615|GO:0050793|GO:0048589|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0048514|GO:0008284|GO:0051272|GO:0042127|GO:0021681|GO:0050804|GO:0042391|GO:0045595|GO:0006725|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:0051130|GO:0021697|GO:1901360|GO:0001568|GO:0010941|GO:0061038|GO:0002088|GO:0007275|GO:0010632|GO:0045596|GO:0048513|GO:0060065|GO:0032535|GO:0005102|GO:0016358|GO:0034641|GO:0021587|GO:0032940|GO:0030902|GO:0030900|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0042246|GO:0033554|GO:0007420|GO:0050806|GO:0022607|GO:0050803|GO:0043231|GO:0048608|GO:0005737|GO:0007389|GO:0007267|GO:0009611|GO:0060322|GO:0007423|GO:0012506|GO:0071559|GO:0006928|GO:0051963|GO:0009887|GO:0001775|GO:0030666|GO:0009966|GO:0048729|GO:0048598|GO:0007548|GO:0050673|GO:0060548|GO:0010646|GO:0006139|GO:0021696|GO:0001525|GO:0021695|GO:0008104|GO:0007163|GO:0007154|GO:0060996|GO:0022037|GO:0051270|GO:0016477|GO:0007165|GO:0051965|GO:0005783|GO:0070062|GO:0050808|GO:0051649|GO:0061351|GO:0009725|GO:0008219|GO:0014834|GO:0001505|GO:0010634|GO:0030546|GO:0030030|GO:0021549|GO:0051301|GO:0048869|GO:2000145|GO:0021683|GO:0009967|GO:0044249|GO:0019827|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0021575|GO:0005794|GO:0060021|GO:0050768|GO:0000165|GO:0006836|GO:0050679|GO:1902533|GO:0032268|GO:0030111|GO:0000902|GO:0031175|GO:0048705|GO:0031344|GO:2000463|GO:0010468|GO:0008105|GO:0090132|GO:0034645|GO:0051216|GO:0007416|GO:0042733|GO:0007166|GO:0001654|GO:0002009|GO:0033993|GO:0060997|GO:0001944|GO:0043412|GO:0050807|GO:0061458|GO:0072358|GO:0007417|GO:0031410|GO:0043069|GO:0097061|GO:0002064|GO:0048813|GO:0009798|GO:0051252|GO:0009880|GO:0060078|GO:0010721|GO:0014719|GO:0005125|GO:0000904|GO:0009790|GO:0010628|GO:0030334|GO:0044319|GO:0001667|GO:0016023|GO:0036211|GO:0071560|GO:0042060|GO:0060856|GO:0005796|GO:0003002|GO:0021533|GO:0031098|GO:0030010|GO:0001570|GO:0051247|GO:0070848|GO:0031988|GO:0021846|GO:0001664|GO:0022604|GO:0060066|GO:0050678|GO:0070306|GO:0043403|GO:0035019|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0030659|GO:0035108|GO:0044267|GO:0051174|GO:0048864|GO:0010467|GO:0032990|GO:0005788|GO:0007399|GO:0046903|GO:0071310|GO:0010594|GO:0098815|GO:0031328|GO:0051246|GO:0030177|GO:0017145|GO:0009059|GO:0030154|GO:0001501|GO:0048858|GO:0061448|GO:0060173|GO:0030335|GO:1902531|GO:0016070|GO:0072359|GO:0010557|GO:0043067|GO:0048545|GO:0097305|GO:0051960|GO:0045165|GO:0010595|GO:0021707|GO:0048666|GO:0030182|GO:0003158|GO:0016055|GO:0021953|GO:0070304|GO:0045893|GO:0048863|GO:0010975|GO:0001885|GO:0000578|GO:0031401|GO:0070307|GO:0030139|GO:0030855|GO:0043408|GO:0010769|GO:0060828|GO:0043010|GO:0002011|GO:0048103|GO:0002062|GO:0032774|GO:2001141|GO:0071363|GO:0016310|GO:0043627|GO:0061564|GO:0031133|GO:0009953|GO:0043410|GO:0032355|GO:0010631|GO:0032872|GO:0042981|GO:0035136|GO:0043066|GO:0005109|GO:0060079|GO:0022008|GO:0048667|GO:0006464|GO:0050767|GO:0090263|GO:0048812|GO:0035137|GO:0030326|GO:0051403|GO:0022009|GO:0006351|GO:0006915|GO:0006355|GO:0060054|GO:0035313|GO:0035115|GO:0035116|GO:0061028|GO:0045944|GO:0045446|GO:0006366|GO:0035567|GO:0046328|GO:0006357|GO:0035659|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0060070|GO:0042325|GO:0007254|GO:0001932|GO:0032874|GO:0001934|GO:0043542|GO:0050770|GO:0045664|GO:0042327|GO:0007268|GO:0046330 locomotion|developmental process|extracellular matrix|growth|signal transducer activity|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|response to stress|cartilage condensation|positive regulation of cellular component biogenesis|receptor agonist activity|single organism reproductive process|organic substance metabolic process|cell surface|cellular metabolic process|cellular localization|developmental process involved in reproduction|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|extracellular space|regulation of developmental process|developmental growth|intracellular|neurotransmitter secretion|protein binding|plasma membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|blood vessel morphogenesis|positive regulation of cell proliferation|positive regulation of cellular component movement|regulation of cell proliferation|cerebellar granular layer development|modulation of synaptic transmission|regulation of membrane potential|regulation of cell differentiation|cellular aromatic compound metabolic process|tissue development|cell development|transport|tube development|positive regulation of cellular component organization|cerebellar cortex formation|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|uterus morphogenesis|lens development in camera-type eye|multicellular organism development|regulation of epithelial cell migration|negative regulation of cell differentiation|animal organ development|uterus development|regulation of cellular component size|receptor binding|dendrite development|cellular nitrogen compound metabolic process|cerebellum morphogenesis|secretion by cell|hindbrain development|forebrain development|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|tissue regeneration|cellular response to stress|brain development|positive regulation of synaptic transmission|cellular component assembly|regulation of synapse structure or activity|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|pattern specification process|cell-cell signaling|response to wounding|head development|sensory organ development|vesicle membrane|response to transforming growth factor beta|movement of cell or subcellular component|regulation of synapse assembly|organ morphogenesis|cell activation|endocytic vesicle membrane|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|sex differentiation|epithelial cell proliferation|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|cerebellar cortex morphogenesis|angiogenesis|cerebellar cortex development|protein localization|establishment or maintenance of cell polarity|cell communication|dendritic spine development|metencephalon development|regulation of cellular component movement|cell migration|signal transduction|positive regulation of synapse assembly|endoplasmic reticulum|extracellular exosome|synapse organization|establishment of localization in cell|neural precursor cell proliferation|response to hormone|cell death|skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration|regulation of neurotransmitter levels|positive regulation of epithelial cell migration|receptor activator activity|cell projection organization|cerebellum development|cell division|cellular developmental process|regulation of cell motility|cerebellar granular layer morphogenesis|positive regulation of signal transduction|cellular biosynthetic process|stem cell population maintenance|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|hindbrain morphogenesis|Golgi apparatus|palate development|negative regulation of neurogenesis|MAPK cascade|neurotransmitter transport|positive regulation of epithelial cell proliferation|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|neuron projection development|skeletal system morphogenesis|regulation of cell projection organization|positive regulation of excitatory postsynaptic potential|regulation of gene expression|asymmetric protein localization|epithelium migration|cellular macromolecule biosynthetic process|cartilage development|synapse assembly|embryonic digit morphogenesis|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|response to lipid|dendritic spine morphogenesis|vasculature development|macromolecule modification|regulation of synapse organization|reproductive system development|cardiovascular system development|central nervous system development|cytoplasmic vesicle|negative regulation of programmed cell death|dendritic spine organization|epithelial cell development|dendrite morphogenesis|axis specification|regulation of RNA metabolic process|embryonic pattern specification|regulation of postsynaptic membrane potential|negative regulation of cell development|skeletal muscle satellite cell activation|cytokine activity|cell morphogenesis involved in differentiation|embryo development|positive regulation of gene expression|regulation of cell migration|wound healing, spreading of cells|ameboidal-type cell migration|cytoplasmic, membrane-bounded vesicle|protein modification process|cellular response to transforming growth factor beta stimulus|wound healing|establishment of blood-brain barrier|Golgi lumen|regionalization|cell differentiation in hindbrain|stress-activated protein kinase signaling cascade|establishment of cell polarity|vasculogenesis|positive regulation of protein metabolic process|response to growth factor|membrane-bounded vesicle|cell proliferation in forebrain|G-protein coupled receptor binding|regulation of cell morphogenesis|oviduct development|regulation of epithelial cell proliferation|lens fiber cell differentiation|skeletal muscle tissue regeneration|somatic stem cell population maintenance|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cytoplasmic vesicle membrane|limb morphogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|stem cell development|gene expression|cell part morphogenesis|endoplasmic reticulum lumen|nervous system development|secretion|cellular response to organic substance|regulation of endothelial cell migration|modulation of excitatory postsynaptic potential|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|positive regulation of Wnt signaling pathway|stem cell division|macromolecule biosynthetic process|cell differentiation|skeletal system development|cell projection morphogenesis|connective tissue development|limb development|positive regulation of cell migration|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|response to steroid hormone|response to alcohol|regulation of nervous system development|cell fate commitment|positive regulation of endothelial cell migration|cerebellar granule cell differentiation|neuron development|neuron differentiation|endothelium development|Wnt signaling pathway|central nervous system neuron differentiation|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|stem cell differentiation|regulation of neuron projection development|endothelial cell development|embryonic axis specification|positive regulation of protein modification process|lens fiber cell development|endocytic vesicle|epithelial cell differentiation|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|regulation of canonical Wnt signaling pathway|camera-type eye development|morphogenesis of an epithelial sheet|somatic stem cell division|chondrocyte differentiation|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|phosphorylation|response to estrogen|axon development|regulation of axon diameter|dorsal/ventral pattern formation|positive regulation of MAPK cascade|response to estradiol|epithelial cell migration|regulation of stress-activated MAPK cascade|regulation of apoptotic process|forelimb morphogenesis|negative regulation of apoptotic process|frizzled binding|excitatory postsynaptic potential|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|regulation of neurogenesis|positive regulation of canonical Wnt signaling pathway|neuron projection morphogenesis|hindlimb morphogenesis|embryonic limb morphogenesis|stress-activated MAPK cascade|central nervous system vasculogenesis|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of epithelial cell proliferation involved in wound healing|wound healing, spreading of epidermal cells|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|establishment of endothelial barrier|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|non-canonical Wnt signaling pathway|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|Wnt signaling pathway involved in wound healing, spreading of epidermal cells|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|endothelial cell migration|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|synaptic transmission|positive regulation of JNK cascade K00572 wingless-type MMTV integration site family, member 7[-] hsa05200|hsa05166|hsa05205|hsa04390|hsa04310|hsa04550|hsa04916|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 3:13816258-13880121 67 88 182 256 330 208 0.953022447385522 1.13759955418422 2.33405825892483 3.26260229307084 3.85131949955515 2.77281278047967 1.47489342016486 3.29557819103522 -1.15992089518636 0.000664222254432417 0.00415281490760741 DOWN ENSG00000196074 SYCP2 synaptonemal complex protein 2 [Source:HGNC Symbol;Acc:HGNC:11490] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0044702|GO:0051321|GO:0019953|GO:0003006|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0007049|GO:0022402|GO:0010941|GO:0007275|GO:0003676|GO:0048513|GO:0022607|GO:0043231|GO:0048608|GO:0035112|GO:0009887|GO:0046983|GO:0007548|GO:0070192|GO:0060548|GO:0007126|GO:0009566|GO:0008219|GO:0007059|GO:0051301|GO:0048806|GO:0006996|GO:0051276|GO:0003677|GO:0046661|GO:0061458|GO:0030539|GO:0043069|GO:0046982|GO:0007129|GO:0007130|GO:0007140|GO:0007127|GO:0048808|GO:0031981|GO:0045132|GO:0007143|GO:0005694|GO:0000228|GO:0012501|GO:0005634|GO:0043067|GO:0000793|GO:0000794|GO:0070193|GO:0045143|GO:0042981|GO:0043066|GO:0000795|GO:0000800|GO:0006915 developmental process|reproduction|cell|cellular process|reproductive process|binding|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|single organism reproductive process|meiotic cell cycle|sexual reproduction|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|cell cycle|cell cycle process|regulation of cell death|multicellular organism development|nucleic acid binding|animal organ development|cellular component assembly|intracellular membrane-bounded organelle|reproductive structure development|genitalia morphogenesis|organ morphogenesis|protein dimerization activity|sex differentiation|chromosome organization involved in meiotic cell cycle|negative regulation of cell death|meiotic nuclear division|fertilization|cell death|chromosome segregation|cell division|genitalia development|organelle organization|chromosome organization|DNA binding|male sex differentiation|reproductive system development|male genitalia development|negative regulation of programmed cell death|protein heterodimerization activity|synapsis|synaptonemal complex assembly|male meiosis|meiosis I|male genitalia morphogenesis|nuclear lumen|meiotic chromosome segregation|female meiotic division|chromosome|nuclear chromosome|programmed cell death|nucleus|regulation of programmed cell death|condensed chromosome|condensed nuclear chromosome|synaptonemal complex organization|homologous chromosome segregation|regulation of apoptotic process|negative regulation of apoptotic process|synaptonemal complex|lateral element|apoptotic process - - - - 20:59863563-59933655 22 13 41 49 63 165 0.183276957461845 0.09842955502129 0.307949594786792 0.365747921377557 0.43062231320139 1.28824494236028 0.196552035756642 0.694871725646409 -1.82183537244041 0.000669332553503321 0.00418213772546843 DOWN ENSG00000177025 C19orf18 chromosome 19 open reading frame 18 [Source:HGNC Symbol;Acc:HGNC:28642] GO:0016020|GO:0005576|GO:1903561|GO:0043227|GO:0031224|GO:0031982|GO:0070062|GO:0016021 membrane|extracellular region|extracellular vesicle|membrane-bounded organelle|intrinsic component of membrane|vesicle|extracellular exosome|integral component of membrane - - - - 19:57958437-57974534 19 19 14 5 4 8 1.46882057539845 1.33496083514775 0.97583904694425 0.346308419593608 0.25370127610879 0.579624568056991 1.25987348583015 0.39321142125313 1.67990173618037 0.000674463902681351 0.00420979413561552 UP ENSG00000183785 TUBA8 tubulin alpha 8 [Source:HGNC Symbol;Acc:HGNC:12410] GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0005200|GO:0097159|GO:0043229|GO:0043167|GO:0016787|GO:0031224|GO:0005622|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0005737|GO:0000166|GO:0016021|GO:0007017|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0017076|GO:0005856|GO:0032561|GO:0015630|GO:0005525|GO:0019001|GO:0016462|GO:0017111|GO:0003924 structural molecule activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|structural constituent of cytoskeleton|organic cyclic compound binding|intracellular organelle|ion binding|hydrolase activity|intrinsic component of membrane|intracellular|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|cytoplasm|nucleotide binding|integral component of membrane|microtubule-based process|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|purine nucleotide binding|cytoskeleton|guanyl ribonucleotide binding|microtubule cytoskeleton|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|GTPase activity K07374 tubulin alpha[-] hsa04145|hsa04210|hsa04540|hsa05130 Phagosome - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Pathogenic Escherichia coli infection - Homo sapiens (human) 22:18110331-18146554 0 0 1 4 10 4 0 0 0.0124916084303046 0.049681248369065 0.113736976376208 0.0519582562239609 0.0041638694767682 0.071792160323078 -4.10782956004689 0.000679476103395772 0.00423664987276052 DOWN ENSG00000232682 RP11-388P9.2 - - - - - - - 10:60050668-60060743 1 1 0 8 3 12 0.0372848753543803 0.0338871057623495 0 0.267147956193192 0.091744763648116 0.419125111318767 0.0237239937055766 0.259339277053358 -3.45042192032988 0.000683598327555177 0.00425968367164105 DOWN ENSG00000253204 RP5-1009N12.1 - - - - - - - 8:30921060-30921335 2 1 2 13 9 7 0.512562050349022 0.233035241800505 0.462159797077634 2.9852138579088 1.89252377849072 1.68141570432764 0.402585696409054 2.18638444690905 -2.44117928191039 0.000684241949779842 0.00426280450098652 DOWN ENSG00000270189 RP11-258C19.7 - - - - - - - X:53169097-53170914 13 12 44 62 59 90 0.505813778218149 0.424338627584617 1.54354650137605 2.16143268712853 1.88354092065647 3.28189921245822 0.824566302392939 2.44229094008107 -1.56652766406589 0.000685267101392143 0.00426741010533188 DOWN ENSG00000250299 MRPS31P4 mitochondrial ribosomal protein S31 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:42649] - - - - - - 13:52600119-52637446 98 103 74 55 49 42 6.51524480607581 6.2233294537613 4.43556611940726 3.27617548501677 2.67281729633992 2.61687395640617 5.72471345974812 2.85528891258762 1.003566751345 0.000689553371301728 0.00429052237324756 UP ENSG00000077616 NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 [Source:HGNC Symbol;Acc:HGNC:14526] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0071944|GO:0016787|GO:0009058|GO:0031224|GO:0005886|GO:0042133|GO:0006082|GO:0034641|GO:0044281|GO:0043169|GO:0008233|GO:0006520|GO:0016810|GO:0001505|GO:0016021|GO:0044249|GO:0019538|GO:0017171|GO:0046872|GO:0042135|GO:0016811|GO:0008652|GO:0006508|GO:0008236|GO:0008237|GO:0050129|GO:0008238|GO:0019752|GO:0004180|GO:0004177|GO:0016805|GO:0008239 cell|membrane|cellular process|metabolic process|binding|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cell periphery|hydrolase activity|biosynthetic process|intrinsic component of membrane|plasma membrane|neurotransmitter metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|cation binding|peptidase activity|cellular amino acid metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|regulation of neurotransmitter levels|integral component of membrane|cellular biosynthetic process|protein metabolic process|serine hydrolase activity|metal ion binding|neurotransmitter catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|cellular amino acid biosynthetic process|proteolysis|serine-type peptidase activity|metallopeptidase activity|N-formylglutamate deformylase activity|exopeptidase activity|carboxylic acid metabolic process|carboxypeptidase activity|aminopeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity - - - - 11:90131515-90192894 44 44 60 20 34 11 0.269239558098361 0.244692153242133 0.331022177460992 0.109649907778949 0.170698781802248 0.0630807712720848 0.281651296267162 0.114476486951094 1.29885880692724 0.000691109837686213 0.00429931091775041 UP ENSG00000167216 KATNAL2 katanin p60 subunit A-like 2 [Source:HGNC Symbol;Acc:HGNC:25387] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0044877|GO:0043229|GO:0043167|GO:0016787|GO:0005622|GO:0005515|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0005737|GO:0032403|GO:0008092|GO:0000166|GO:0007017|GO:0015631|GO:0035639|GO:0001883|GO:0008017|GO:0016818|GO:0032549|GO:0051013|GO:0017076|GO:0005856|GO:0005524|GO:0030554|GO:0015630|GO:0016462|GO:0017111|GO:0016887|GO:0042623|GO:0008568 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|ion binding|hydrolase activity|intracellular|protein binding|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|cytoplasm|protein complex binding|cytoskeletal protein binding|nucleotide binding|microtubule-based process|tubulin binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|microtubule binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|microtubule severing|purine nucleotide binding|cytoskeleton|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|ATPase activity|ATPase activity, coupled|microtubule-severing ATPase activity - - - - 18:46917492-47102243 3 5 2 19 9 20 0.0344479498975725 0.0521777203462453 0.0207037987329049 0.195455955270871 0.084781133397734 0.215201418772142 0.0357764896589076 0.165146169146916 -2.20665976003913 0.000694234161329313 0.00431708068064559 DOWN ENSG00000176826 FKBP9P1 FK506 binding protein 9 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:23568] - - - - - - 7:55681074-55713252 29 27 30 72 65 64 0.5648052634692 0.477915082817386 0.526782712430525 1.25641331257379 1.0386790735718 1.16818607879327 0.523167686239037 1.15442615497962 -1.14183055159696 0.000696912040026409 0.00433089343108835 DOWN ENSG00000231427 LINC01445 long intergenic non-protein coding RNA 1445 [Source:HGNC Symbol;Acc:HGNC:50771] - - - - - - 7:54330697-54349849 1 0 0 6 4 7 0.0498708198890866 0 0 0.267995148443276 0.163591731951757 0.327040686676835 0.0166236066296955 0.252875855690623 -3.92712397076991 0.000697600735584364 0.00433427104269211 DOWN ENSG00000105877 DNAH11 dynein, axonemal, heavy chain 11 [Source:HGNC Symbol;Acc:HGNC:2942] GO:0040011|GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0048870|GO:0016787|GO:0005622|GO:0043234|GO:0048856|GO:0005929|GO:0007507|GO:0007275|GO:0048513|GO:0043168|GO:0005874|GO:0001882|GO:0016817|GO:0005737|GO:0007389|GO:0032886|GO:0030317|GO:0006928|GO:0072372|GO:0005875|GO:0051270|GO:0000166|GO:0007017|GO:0035639|GO:0072358|GO:0001883|GO:0031512|GO:0016818|GO:0032549|GO:0060632|GO:0007018|GO:0030286|GO:0017076|GO:0072359|GO:0005856|GO:0005524|GO:0030554|GO:0015630|GO:0009855|GO:0016462|GO:0003341|GO:0007368|GO:0017111|GO:0003356|GO:0016887|GO:0003774|GO:0003777 locomotion|developmental process|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|cell motility|hydrolase activity|intracellular|protein complex|anatomical structure development|cilium|heart development|multicellular organism development|animal organ development|anion binding|microtubule|nucleoside binding|hydrolase activity, acting on acid anhydrides|cytoplasm|pattern specification process|regulation of microtubule-based process|sperm motility|movement of cell or subcellular component|primary cilium|microtubule associated complex|regulation of cellular component movement|nucleotide binding|microtubule-based process|purine ribonucleoside triphosphate binding|cardiovascular system development|purine nucleoside binding|motile primary cilium|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|regulation of microtubule-based movement|microtubule-based movement|dynein complex|purine nucleotide binding|circulatory system development|cytoskeleton|ATP binding|adenyl nucleotide binding|microtubule cytoskeleton|determination of bilateral symmetry|pyrophosphatase activity|cilium movement|determination of left/right symmetry|nucleoside-triphosphatase activity|regulation of cilium beat frequency|ATPase activity|motor activity|microtubule motor activity K10408 dynein heavy chain, axonemal[-] hsa05016 Huntington,s disease - Homo sapiens (human) 7:21543215-21901839 97 94 213 252 258 519 0.36917323685796 0.325137544142501 0.730891959504703 0.859327553600882 0.805652708868575 1.85121077008556 0.475067580168388 1.17206367751834 -1.30284629064156 0.000701529891513517 0.00435777640059187 DOWN ENSG00000167700 MFSD3 major facilitator superfamily domain containing 3 [Source:HGNC Symbol;Acc:HGNC:25157] GO:0005215|GO:0016020|GO:0009987|GO:0022857|GO:0031224|GO:0006810|GO:0022891|GO:0055085|GO:0016021|GO:0008521|GO:0051181|GO:0006811|GO:0015075|GO:0006820|GO:0015711|GO:0015293|GO:0015992|GO:0006812|GO:0008324|GO:0015876|GO:0015672|GO:0015295 transporter activity|membrane|cellular process|transmembrane transporter activity|intrinsic component of membrane|transport|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|acetyl-CoA transporter activity|cofactor transport|ion transport|ion transmembrane transporter activity|anion transport|organic anion transport|symporter activity|proton transport|cation transport|cation transmembrane transporter activity|acetyl-CoA transport|monovalent inorganic cation transport|solute:proton symporter activity - - - - 8:144509074-144511213 131 154 230 220 440 557 2.0633550305895 2.20446326434574 3.26621052529986 3.10472917969702 5.68621177484252 8.22218086860732 2.51134294007837 5.67104060771562 -1.17515443543913 0.000705446477563631 0.00438028268327467 DOWN ENSG00000095397 DFNB31 deafness, autosomal recessive 31 [Source:HGNC Symbol;Acc:HGNC:16361] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0042995|GO:0043229|GO:0032420|GO:0071704|GO:0009653|GO:0016043|GO:0030427|GO:0071944|GO:0032426|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0019222|GO:0042802|GO:0002142|GO:0021692|GO:0048468|GO:0021697|GO:0048839|GO:0005884|GO:0007275|GO:0048513|GO:0032421|GO:0050877|GO:0021587|GO:0030902|GO:0030426|GO:0007420|GO:0005737|GO:0060322|GO:0007423|GO:0042592|GO:0001917|GO:0043005|GO:0046983|GO:0045184|GO:0072372|GO:0048871|GO:0036064|GO:0021696|GO:0021695|GO:0008104|GO:0022037|GO:1990696|GO:0021694|GO:0030030|GO:0021549|GO:0031253|GO:0048869|GO:0043954|GO:0021680|GO:0021575|GO:0010468|GO:0045216|GO:0060113|GO:0007417|GO:0043583|GO:0046982|GO:0001894|GO:0005815|GO:1990075|GO:0002141|GO:0010628|GO:0007600|GO:0060122|GO:0010467|GO:0007399|GO:0030154|GO:0005856|GO:0042803|GO:0031513|GO:0048666|GO:0030182|GO:0015629|GO:0050953|GO:0050954|GO:0032391|GO:0001895|GO:0015630|GO:0045217|GO:0060119|GO:0022008|GO:0007605|GO:1990227|GO:0048699|GO:0042490 developmental process|macromolecular complex|cell|membrane|cellular process|metabolic process|binding|cell projection|intracellular organelle|stereocilium|organic substance metabolic process|anatomical structure morphogenesis|cellular component organization|site of polarized growth|cell periphery|stereocilium tip|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|stereocilia ankle link complex|cerebellar Purkinje cell layer morphogenesis|cell development|cerebellar cortex formation|inner ear development|actin filament|multicellular organism development|animal organ development|stereocilium bundle|neurological system process|cerebellum morphogenesis|hindbrain development|growth cone|brain development|cytoplasm|head development|sensory organ development|homeostatic process|photoreceptor inner segment|neuron projection|protein dimerization activity|establishment of protein localization|primary cilium|multicellular organismal homeostasis|ciliary basal body|cerebellar cortex morphogenesis|cerebellar cortex development|protein localization|metencephalon development|USH2 complex|cerebellar Purkinje cell layer formation|cell projection organization|cerebellum development|cell projection membrane|cellular developmental process|cellular component maintenance|cerebellar Purkinje cell layer development|hindbrain morphogenesis|regulation of gene expression|cell-cell junction organization|inner ear receptor cell differentiation|central nervous system development|ear development|protein heterodimerization activity|tissue homeostasis|microtubule organizing center|periciliary membrane compartment|stereocilia ankle link|positive regulation of gene expression|sensory perception|inner ear receptor stereocilium organization|gene expression|nervous system development|cell differentiation|cytoskeleton|protein homodimerization activity|nonmotile primary cilium|neuron development|neuron differentiation|actin cytoskeleton|sensory perception of light stimulus|sensory perception of mechanical stimulus|photoreceptor connecting cilium|retina homeostasis|microtubule cytoskeleton|cell-cell junction maintenance|inner ear receptor cell development|neurogenesis|sensory perception of sound|paranodal junction maintenance|generation of neurons|mechanoreceptor differentiation - - - - 9:114402080-114505450 80 79 299 335 369 621 0.74489273129509 0.668517479123912 2.51008778917524 2.7947674429184 2.81901930816713 5.4190595764568 1.30783266653141 3.67761544251411 -1.49159266531958 0.000706608865986224 0.00438658787381009 DOWN ENSG00000173480 ZNF417 zinc finger protein 417 [Source:HGNC Symbol;Acc:HGNC:20646] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57900296-57916610 175 226 222 351 359 601 1.66652352369339 1.95596799540518 1.90607526294399 2.99487640085628 2.80502017955006 5.36385832812158 1.84285559401419 3.72125163617597 -1.0138449248398 0.000714028806349235 0.00442988694612428 DOWN ENSG00000205464 ATP6AP1L ATPase, H+ transporting, lysosomal accessory protein 1-like [Source:HGNC Symbol;Acc:HGNC:28091] GO:0032991|GO:0005215|GO:0016020|GO:0009987|GO:0003824|GO:0022857|GO:0016787|GO:0031224|GO:0043234|GO:0006810|GO:0016817|GO:0033178|GO:0022891|GO:0055085|GO:0016469|GO:0016021|GO:0016820|GO:0016818|GO:0006811|GO:0033176|GO:0015075|GO:0033180|GO:0090662|GO:0034220|GO:0098655|GO:0015992|GO:0006812|GO:0015991|GO:0042625|GO:0042626|GO:0016462|GO:0008324|GO:0019829|GO:1902600|GO:0017111|GO:0022890|GO:0015672|GO:0016887|GO:0046933|GO:0046961|GO:0015077|GO:0042623|GO:0015078|GO:0043492 macromolecular complex|transporter activity|membrane|cellular process|catalytic activity|transmembrane transporter activity|hydrolase activity|intrinsic component of membrane|protein complex|transport|hydrolase activity, acting on acid anhydrides|proton-transporting two-sector ATPase complex, catalytic domain|substrate-specific transmembrane transporter activity|transmembrane transport|proton-transporting two-sector ATPase complex|integral component of membrane|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|proton-transporting V-type ATPase complex|ion transmembrane transporter activity|proton-transporting V-type ATPase, V1 domain|ATP hydrolysis coupled transmembrane transport|ion transmembrane transport|cation transmembrane transport|proton transport|cation transport|ATP hydrolysis coupled proton transport|ATPase coupled ion transmembrane transporter activity|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|cation transmembrane transporter activity|cation-transporting ATPase activity|hydrogen ion transmembrane transport|nucleoside-triphosphatase activity|inorganic cation transmembrane transporter activity|monovalent inorganic cation transport|ATPase activity|proton-transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|monovalent inorganic cation transmembrane transporter activity|ATPase activity, coupled|hydrogen ion transmembrane transporter activity|ATPase activity, coupled to movement of substances - - - - 5:82279462-82386977 7 7 11 26 21 30 0.0531410250173432 0.0482980831950372 0.0752870999986027 0.176844607165235 0.130801104006332 0.213442200937234 0.0589087360703277 0.173695970702934 -1.5600107832682 0.000714584071609544 0.00443241073630404 DOWN ENSG00000135625 EGR4 early growth response 4 [Source:HGNC Symbol;Acc:HGNC:3241] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 2:73290929-73293705 8 7 9 1 4 0 0.119155296606722 0.0947655378419365 0.120861043123511 0.0133393963994129 0.0488811681700449 0 0.111593959190723 0.0207401881898193 2.42775804337167 0.000714754390842078 0.00443254623685072 UP ENSG00000261071 RP1-223E5.4 - - - - - - - 6:13614111-13615155 0 0 0 9 0 9 0 0 0 0.545833123785158 0 0.570949497751067 0 0.372260873845408 -Inf 0.000715061513211615 0.00443260930552731 DOWN ENSG00000016082 ISL1 ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0060341|GO:0008284|GO:0042127|GO:0006935|GO:0045595|GO:0003712|GO:0006725|GO:0046887|GO:0009888|GO:0048468|GO:0006810|GO:0051130|GO:1901360|GO:0001568|GO:0010941|GO:0007275|GO:0060411|GO:0016570|GO:0003676|GO:0045596|GO:0048513|GO:0005102|GO:0034641|GO:0032940|GO:0006952|GO:0030900|GO:0021517|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0007420|GO:0001817|GO:0051098|GO:0061061|GO:0043231|GO:0043169|GO:0005737|GO:0000981|GO:0007389|GO:0001816|GO:0007267|GO:0009611|GO:0060322|GO:0001076|GO:0032880|GO:0051222|GO:0006928|GO:0009887|GO:0009966|GO:0048729|GO:0045184|GO:0009890|GO:0046883|GO:0003682|GO:0060384|GO:0001819|GO:0060548|GO:0010646|GO:0006139|GO:0001525|GO:0008104|GO:0007154|GO:0044092|GO:0016477|GO:0007165|GO:0003151|GO:0009968|GO:0003279|GO:0008134|GO:0009725|GO:0021675|GO:0008219|GO:0048645|GO:0031016|GO:0051047|GO:0030030|GO:0010817|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0021536|GO:0048732|GO:0006996|GO:0003205|GO:0003713|GO:0050768|GO:0032735|GO:0051276|GO:0000982|GO:1902533|GO:0032268|GO:0030111|GO:0000902|GO:0016922|GO:0010574|GO:0031175|GO:0003677|GO:0010468|GO:0034645|GO:0003156|GO:0030178|GO:1901215|GO:0051101|GO:0046872|GO:0007166|GO:0090276|GO:0051100|GO:0033993|GO:0002793|GO:0003208|GO:0032675|GO:0031102|GO:0001944|GO:0043412|GO:0072358|GO:0001104|GO:0003148|GO:0007417|GO:0001085|GO:0032635|GO:0010629|GO:0050727|GO:0051427|GO:0042692|GO:0043069|GO:0031056|GO:0048678|GO:0051252|GO:0006325|GO:0021510|GO:0035051|GO:0048738|GO:0003007|GO:0070997|GO:0010721|GO:0051223|GO:0032655|GO:0043425|GO:0015031|GO:0001709|GO:0000904|GO:0009790|GO:0031058|GO:0016573|GO:0010628|GO:0032755|GO:0001667|GO:0032615|GO:0036211|GO:0010575|GO:0070201|GO:0060537|GO:0042886|GO:0060037|GO:2000027|GO:0006954|GO:0050714|GO:0060413|GO:0021983|GO:0045766|GO:0060914|GO:0003002|GO:0051046|GO:0060485|GO:0035270|GO:0031981|GO:0003231|GO:0045765|GO:0050728|GO:0001708|GO:0009914|GO:0009306|GO:0051099|GO:0051247|GO:0005654|GO:0003209|GO:0033143|GO:0010092|GO:1901214|GO:0033144|GO:0003283|GO:0032270|GO:0012501|GO:0003197|GO:0014070|GO:0006796|GO:1901342|GO:1901256|GO:0035556|GO:0033043|GO:0044267|GO:0032609|GO:0051174|GO:0048864|GO:0010467|GO:0032990|GO:0032725|GO:0007399|GO:0046903|GO:0071310|GO:0097485|GO:0060415|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0009755|GO:0048858|GO:0048880|GO:0001228|GO:0007517|GO:0001191|GO:0032729|GO:1902531|GO:0016070|GO:1901258|GO:0072359|GO:0021522|GO:0033613|GO:0032870|GO:0010557|GO:0005634|GO:0043067|GO:0048545|GO:0051960|GO:0045165|GO:0030522|GO:0010573|GO:0032652|GO:0048644|GO:0032649|GO:0007422|GO:0090277|GO:0043393|GO:0021545|GO:0010638|GO:0048666|GO:0032732|GO:2001252|GO:0030182|GO:0050796|GO:0043401|GO:0032680|GO:0002790|GO:0007411|GO:0016055|GO:0021953|GO:0060913|GO:0001755|GO:0000975|GO:0045893|GO:0048863|GO:0030073|GO:0001102|GO:0009792|GO:0031401|GO:0090090|GO:0045445|GO:0032651|GO:0043496|GO:0021520|GO:0060828|GO:0045892|GO:0043523|GO:0071657|GO:0021559|GO:0032774|GO:0048934|GO:0043565|GO:0032731|GO:2001141|GO:0035257|GO:0014031|GO:0001077|GO:0050708|GO:0016310|GO:0015833|GO:0033044|GO:0021524|GO:0021515|GO:1902679|GO:0043388|GO:0071383|GO:0032640|GO:0071407|GO:0035066|GO:0032611|GO:0003690|GO:0048663|GO:0061564|GO:0030518|GO:0001105|GO:0048665|GO:0032024|GO:0042981|GO:0035065|GO:0046914|GO:0003215|GO:0003229|GO:0043066|GO:0016568|GO:0048762|GO:0051402|GO:0003264|GO:0032760|GO:0045665|GO:0043524|GO:0032730|GO:0055008|GO:0014706|GO:0022008|GO:0048667|GO:0006464|GO:0031103|GO:2000826|GO:0055010|GO:0033147|GO:0050767|GO:0048812|GO:0032091|GO:0048935|GO:0071396|GO:0031960|GO:0046879|GO:0006351|GO:0003203|GO:0010002|GO:0006915|GO:0006355|GO:0033146|GO:0090074|GO:0014033|GO:0060379|GO:0030520|GO:0051384|GO:0014032|GO:0045944|GO:0006366|GO:0030072|GO:0007259|GO:1903507|GO:0035258|GO:0006357|GO:0007409|GO:0006468|GO:0048699|GO:1903506|GO:0046425|GO:0003266|GO:0044212|GO:0060070|GO:0001190|GO:0042325|GO:0001932|GO:0018193|GO:0046427|GO:0043009|GO:0071384|GO:0001934|GO:1901985|GO:0000122|GO:0048936|GO:0003139|GO:0031290|GO:0008270|GO:0045664|GO:0042327|GO:0050731|GO:0071385|GO:0035326|GO:0050730|GO:0000976|GO:0001012|GO:0007260|GO:0042531|GO:0001159|GO:0030331|GO:0006473|GO:0018205|GO:0018108|GO:0018394|GO:0042516|GO:0042517|GO:0000977|GO:0000987|GO:0001158|GO:0042503|GO:0006475|GO:0018393|GO:0000978 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|cell motility|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|chemotaxis|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|positive regulation of hormone secretion|tissue development|cell development|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|multicellular organism development|cardiac septum morphogenesis|histone modification|nucleic acid binding|negative regulation of cell differentiation|animal organ development|receptor binding|cellular nitrogen compound metabolic process|secretion by cell|defense response|forebrain development|ventral spinal cord development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|brain development|regulation of cytokine production|regulation of binding|muscle structure development|intracellular membrane-bounded organelle|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|cytokine production|cell-cell signaling|response to wounding|head development|transcription factor activity, RNA polymerase II transcription factor binding|regulation of protein localization|positive regulation of protein transport|movement of cell or subcellular component|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|establishment of protein localization|negative regulation of biosynthetic process|regulation of hormone secretion|chromatin binding|innervation|positive regulation of cytokine production|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|protein localization|cell communication|negative regulation of molecular function|cell migration|signal transduction|outflow tract morphogenesis|negative regulation of signal transduction|cardiac septum development|transcription factor binding|response to hormone|nerve development|cell death|organ formation|pancreas development|positive regulation of secretion|cell projection organization|regulation of hormone levels|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|diencephalon development|gland development|organelle organization|cardiac chamber development|transcription coactivator activity|negative regulation of neurogenesis|positive regulation of interleukin-12 production|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|ligand-dependent nuclear receptor binding|regulation of vascular endothelial growth factor production|neuron projection development|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of organ formation|negative regulation of Wnt signaling pathway|negative regulation of neuron death|regulation of DNA binding|metal ion binding|cell surface receptor signaling pathway|regulation of peptide hormone secretion|negative regulation of binding|response to lipid|positive regulation of peptide secretion|cardiac ventricle morphogenesis|regulation of interleukin-6 production|neuron projection regeneration|vasculature development|macromolecule modification|cardiovascular system development|RNA polymerase II transcription cofactor activity|outflow tract septum morphogenesis|central nervous system development|RNA polymerase II transcription factor binding|interleukin-6 production|negative regulation of gene expression|regulation of inflammatory response|hormone receptor binding|muscle cell differentiation|negative regulation of programmed cell death|regulation of histone modification|response to axon injury|regulation of RNA metabolic process|chromatin organization|spinal cord development|cardiocyte differentiation|cardiac muscle tissue development|heart morphogenesis|neuron death|negative regulation of cell development|regulation of protein transport|regulation of interleukin-12 production|bHLH transcription factor binding|protein transport|cell fate determination|cell morphogenesis involved in differentiation|embryo development|positive regulation of histone modification|histone acetylation|positive regulation of gene expression|positive regulation of interleukin-6 production|ameboidal-type cell migration|interleukin-12 production|protein modification process|positive regulation of vascular endothelial growth factor production|regulation of establishment of protein localization|muscle tissue development|amide transport|pharyngeal system development|regulation of organ morphogenesis|inflammatory response|positive regulation of protein secretion|atrial septum morphogenesis|pituitary gland development|positive regulation of angiogenesis|heart formation|regionalization|regulation of secretion|mesenchyme development|endocrine system development|nuclear lumen|cardiac ventricle development|regulation of angiogenesis|negative regulation of inflammatory response|cell fate specification|hormone transport|protein secretion|positive regulation of binding|positive regulation of protein metabolic process|nucleoplasm|cardiac atrium morphogenesis|regulation of intracellular steroid hormone receptor signaling pathway|specification of organ identity|regulation of neuron death|negative regulation of intracellular steroid hormone receptor signaling pathway|atrial septum development|positive regulation of cellular protein metabolic process|programmed cell death|endocardial cushion development|response to organic cyclic compound|phosphate-containing compound metabolic process|regulation of vasculature development|regulation of macrophage colony-stimulating factor production|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|interferon-gamma production|regulation of phosphorus metabolic process|stem cell development|gene expression|cell part morphogenesis|positive regulation of granulocyte macrophage colony-stimulating factor production|nervous system development|secretion|cellular response to organic substance|neuron projection guidance|muscle tissue morphogenesis|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|cell projection morphogenesis|sensory system development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|muscle organ development|transcriptional repressor activity, RNA polymerase II transcription factor binding|positive regulation of interferon-gamma production|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macrophage colony-stimulating factor production|circulatory system development|spinal cord motor neuron differentiation|activating transcription factor binding|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|response to steroid hormone|regulation of nervous system development|cell fate commitment|intracellular receptor signaling pathway|vascular endothelial growth factor production|regulation of interleukin-1 production|muscle organ morphogenesis|regulation of interferon-gamma production|peripheral nervous system development|positive regulation of peptide hormone secretion|regulation of protein binding|cranial nerve development|positive regulation of organelle organization|neuron development|positive regulation of interleukin-1 production|positive regulation of chromosome organization|neuron differentiation|regulation of insulin secretion|steroid hormone mediated signaling pathway|regulation of tumor necrosis factor production|peptide secretion|axon guidance|Wnt signaling pathway|central nervous system neuron differentiation|cardiac cell fate determination|neural crest cell migration|regulatory region DNA binding|positive regulation of transcription, DNA-templated|stem cell differentiation|insulin secretion|RNA polymerase II activating transcription factor binding|embryo development ending in birth or egg hatching|positive regulation of protein modification process|negative regulation of canonical Wnt signaling pathway|myoblast differentiation|regulation of interleukin-1 beta production|regulation of protein homodimerization activity|spinal cord motor neuron cell fate specification|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|positive regulation of granulocyte colony-stimulating factor production|trigeminal nerve development|RNA biosynthetic process|peripheral nervous system neuron differentiation|sequence-specific DNA binding|positive regulation of interleukin-1 beta production|regulation of RNA biosynthetic process|nuclear hormone receptor binding|mesenchymal cell development|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of protein secretion|phosphorylation|peptide transport|regulation of chromosome organization|visceral motor neuron differentiation|cell differentiation in spinal cord|negative regulation of RNA biosynthetic process|positive regulation of DNA binding|cellular response to steroid hormone stimulus|tumor necrosis factor production|cellular response to organic cyclic compound|positive regulation of histone acetylation|interleukin-1 beta production|double-stranded DNA binding|neuron fate commitment|axon development|intracellular steroid hormone receptor signaling pathway|RNA polymerase II transcription coactivator activity|neuron fate specification|positive regulation of insulin secretion|regulation of apoptotic process|regulation of histone acetylation|transition metal ion binding|cardiac right ventricle morphogenesis|ventricular cardiac muscle tissue development|negative regulation of apoptotic process|chromatin modification|mesenchymal cell differentiation|neuron apoptotic process|regulation of cardioblast proliferation|positive regulation of tumor necrosis factor production|negative regulation of neuron differentiation|negative regulation of neuron apoptotic process|positive regulation of interleukin-1 alpha production|cardiac muscle tissue morphogenesis|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|axon regeneration|regulation of heart morphogenesis|ventricular cardiac muscle tissue morphogenesis|negative regulation of intracellular estrogen receptor signaling pathway|regulation of neurogenesis|neuron projection morphogenesis|negative regulation of protein binding|peripheral nervous system neuron development|cellular response to lipid|response to corticosteroid|hormone secretion|transcription, DNA-templated|endocardial cushion morphogenesis|cardioblast differentiation|apoptotic process|regulation of transcription, DNA-templated|regulation of intracellular estrogen receptor signaling pathway|negative regulation of protein homodimerization activity|neural crest cell differentiation|cardiac muscle cell myoblast differentiation|intracellular estrogen receptor signaling pathway|response to glucocorticoid|neural crest cell development|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|JAK-STAT cascade|negative regulation of nucleic acid-templated transcription|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|axonogenesis|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|regulation of JAK-STAT cascade|regulation of secondary heart field cardioblast proliferation|transcription regulatory region DNA binding|canonical Wnt signaling pathway|transcriptional activator activity, RNA polymerase II transcription factor binding|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of JAK-STAT cascade|chordate embryonic development|cellular response to corticosteroid stimulus|positive regulation of protein phosphorylation|positive regulation of protein acetylation|negative regulation of transcription from RNA polymerase II promoter|peripheral nervous system neuron axonogenesis|secondary heart field specification|retinal ganglion cell axon guidance|zinc ion binding|regulation of neuron differentiation|positive regulation of phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|cellular response to glucocorticoid stimulus|enhancer binding|regulation of peptidyl-tyrosine phosphorylation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|tyrosine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|core promoter proximal region DNA binding|estrogen receptor binding|protein acetylation|peptidyl-lysine modification|peptidyl-tyrosine phosphorylation|peptidyl-lysine acetylation|regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|enhancer sequence-specific DNA binding|tyrosine phosphorylation of Stat3 protein|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09370 insulin gene enhancer protein ISL-1[-] - - 5:51383391-51394738 15 30 33 4 14 10 0.331573929592789 0.602693456991276 0.657700731785836 0.0792260657585434 0.253917643152292 0.20716499078987 0.530656039456634 0.180102899900235 1.55895562735955 0.000722717500025494 0.00447542174772062 UP ENSG00000158806 NPM2 nucleophosmin/nucleoplasmin 2 [Source:HGNC Symbol;Acc:HGNC:7930] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0051321|GO:0071704|GO:0019953|GO:0044237|GO:0003006|GO:0000785|GO:0016043|GO:0043227|GO:0009893|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0019222|GO:0051726|GO:0007049|GO:0006725|GO:0042393|GO:0048468|GO:0009994|GO:0022402|GO:0051130|GO:1901360|GO:0007275|GO:0051302|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0022607|GO:0043231|GO:0019899|GO:0000789|GO:0005737|GO:0051445|GO:0045787|GO:0003682|GO:0006139|GO:0043085|GO:0000790|GO:0007276|GO:0007126|GO:0009566|GO:0050790|GO:0051781|GO:0051301|GO:0048869|GO:0044249|GO:0007281|GO:0031323|GO:0006996|GO:0051446|GO:0045836|GO:0051276|GO:0040020|GO:0034645|GO:0090068|GO:1903047|GO:0006325|GO:0044770|GO:0048477|GO:0009790|GO:0000278|GO:0007338|GO:0031981|GO:0007346|GO:0010564|GO:0006259|GO:0005694|GO:0000228|GO:0006461|GO:0051054|GO:0033043|GO:0007067|GO:0031328|GO:0009059|GO:0030154|GO:0007292|GO:0010557|GO:0005634|GO:0010638|GO:0006260|GO:0051259|GO:0007088|GO:0044772|GO:1901990|GO:0006275|GO:0016568|GO:1901987|GO:0045740|GO:0010458|GO:0006338|GO:0051260|GO:0007096 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|chromatin|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|histone binding|cell development|oocyte differentiation|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|regulation of cell division|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasmic chromatin|cytoplasm|regulation of meiotic cell cycle|positive regulation of cell cycle|chromatin binding|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nuclear chromatin|gamete generation|meiotic nuclear division|fertilization|regulation of catalytic activity|positive regulation of cell division|cell division|cellular developmental process|cellular biosynthetic process|germ cell development|regulation of cellular metabolic process|organelle organization|positive regulation of meiotic cell cycle|positive regulation of meiotic nuclear division|chromosome organization|regulation of meiotic nuclear division|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|mitotic cell cycle process|chromatin organization|cell cycle phase transition|oogenesis|embryo development|mitotic cell cycle|single fertilization|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|DNA metabolic process|chromosome|nuclear chromosome|protein complex assembly|positive regulation of DNA metabolic process|regulation of organelle organization|mitotic nuclear division|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|female gamete generation|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of organelle organization|DNA replication|protein oligomerization|regulation of mitotic nuclear division|mitotic cell cycle phase transition|regulation of mitotic cell cycle phase transition|regulation of DNA replication|chromatin modification|regulation of cell cycle phase transition|positive regulation of DNA replication|exit from mitosis|chromatin remodeling|protein homooligomerization|regulation of exit from mitosis - - - - 8:22024125-22036897 9 2 3 0 0 0 0.143031947204658 0.0288866780854053 0.0429792814678211 0 0 0 0.0716326355859615 0 Inf 0.000723157940231919 0.00447722047857398 UP ENSG00000168495 POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa [Source:HGNC Symbol;Acc:HGNC:1080] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0097159|GO:0044877|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0000785|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0002684|GO:0005622|GO:0002682|GO:0043234|GO:0016740|GO:0045087|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0006952|GO:0016772|GO:0046483|GO:0098542|GO:0001817|GO:0043231|GO:0005737|GO:0001816|GO:0009615|GO:0003682|GO:0001819|GO:0006139|GO:0050776|GO:0000790|GO:0050778|GO:0051607|GO:0044249|GO:0005829|GO:0003677|GO:0034645|GO:0032479|GO:0032481|GO:0031981|GO:1990234|GO:0032606|GO:0005654|GO:0005694|GO:0000228|GO:0010467|GO:0009059|GO:0016779|GO:0016070|GO:0005634|GO:0045089|GO:0045088|GO:0032774|GO:0032728|GO:0032608|GO:0032648|GO:0006351|GO:0005666|GO:0003899|GO:0006383|GO:0006354|GO:0006353|GO:0001056|GO:0006385|GO:0006386 macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|chromatin|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein complex|transferase activity|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|transferase activity, transferring phosphorus-containing groups|heterocycle metabolic process|defense response to other organism|regulation of cytokine production|intracellular membrane-bounded organelle|cytoplasm|cytokine production|response to virus|chromatin binding|positive regulation of cytokine production|nucleobase-containing compound metabolic process|regulation of immune response|nuclear chromatin|positive regulation of immune response|defense response to virus|cellular biosynthetic process|cytosol|DNA binding|cellular macromolecule biosynthetic process|regulation of type I interferon production|positive regulation of type I interferon production|nuclear lumen|transferase complex|type I interferon production|nucleoplasm|chromosome|nuclear chromosome|gene expression|macromolecule biosynthetic process|nucleotidyltransferase activity|RNA metabolic process|nucleus|positive regulation of innate immune response|regulation of innate immune response|RNA biosynthetic process|positive regulation of interferon-beta production|interferon-beta production|regulation of interferon-beta production|transcription, DNA-templated|DNA-directed RNA polymerase III complex|DNA-directed RNA polymerase activity|transcription from RNA polymerase III promoter|DNA-templated transcription, elongation|DNA-templated transcription, termination|RNA polymerase III activity|transcription elongation from RNA polymerase III promoter|termination of RNA polymerase III transcription K03026 DNA-directed RNA polymerase III subunit RPC4[-] hsa01100|hsa05169|hsa00230|hsa00240|hsa04623|hsa03020 Metabolic pathways - Homo sapiens (human)|Epstein-Barr virus infection - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Pyrimidine metabolism - Homo sapiens (human)|Cytosolic DNA-sensing pathway - Homo sapiens (human)|RNA polymerase - Homo sapiens (human) 8:22245104-22254600 157 160 341 428 437 512 1.48531046408702 1.37568120003359 2.90861954926742 3.62793998405198 3.39209624725994 4.53959243525689 1.92320373779601 3.85320955552294 -1.00254904354265 0.000723634689446186 0.0044792432135033 DOWN ENSG00000250709 CCDC169-SOHLH2 CCDC169-SOHLH2 readthrough [Source:HGNC Symbol;Acc:HGNC:38866] GO:0005488|GO:0005515|GO:0046983 binding|protein binding|protein dimerization activity - - - - 13:36168794-36297842 0 52 0 0 0 0 0 1.62990721994715 0 0 0 0 0.54330240664905 0 Inf 0.000725725307840762 0.00449032193580894 UP ENSG00000108306 FBXL20 F-box and leucine-rich repeat protein 20 [Source:HGNC Symbol;Acc:HGNC:24679] GO:0007610|GO:0005623|GO:0050896|GO:0005488|GO:0006950|GO:0044708|GO:0005622|GO:0005515|GO:0006952|GO:0005737|GO:0001662|GO:0033555|GO:0042596 behavior|cell|response to stimulus|binding|response to stress|single-organism behavior|intracellular|protein binding|defense response|cytoplasm|behavioral fear response|multicellular organismal response to stress|fear response - - - - 17:39252644-39402523 89 39 139 230 191 299 0.477082849094933 0.18999963668851 0.671788087928546 1.10465922657439 0.840050812215731 1.50211472826628 0.44629019123733 1.1489415890188 -1.36425145088792 0.000727573385159698 0.00449802771599868 DOWN ENSG00000234814 SVILP1 supervillin pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44959] - - - - - - 10:30671566-30717266 0 0 1 6 3 9 0 0 0.0225724779815313 0.134661868144833 0.0616613177776643 0.211275575477997 0.0075241593271771 0.135866253800165 -4.17451295769627 0.00073715598033863 0.00455444011527927 DOWN ENSG00000181355 OFCC1 orofacial cleft 1 candidate 1 [Source:HGNC Symbol;Acc:HGNC:21017] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 6:9596110-10211608 2 1 3 8 10 13 0.0208131713838944 0.0094626639306958 0.0281448847746464 0.074598620105146 0.0853905826758557 0.126799429661783 0.0194735733630789 0.0955962108142616 -2.29543579454947 0.00074056559710035 0.00457361301941122 DOWN ENSG00000249602 RP11-98D18.3 - - - - - - - 1:151763384-151769501 22 13 9 3 5 4 4.07383415133123 2.18786741278998 1.50253689474752 0.497671462603354 0.75968558959135 0.694091574635792 2.58807948628958 0.650482875610165 1.99229894406651 0.000744555807442068 0.00459350466529769 UP ENSG00000260196 RP1-239B22.5 - - - - - - - 11:17380649-17383531 12 12 14 2 7 2 0.294439478434575 0.267585024262516 0.309709583057228 0.0439686802683557 0.140918567132732 0.0459838677611641 0.290578028584773 0.0769570383874173 1.91680043624669 0.000745114494519378 0.00459497318102527 UP ENSG00000279717 LLNLF-158E9.1 - - - - - - - 19:15904556-15907234 6 4 15 3 0 0 0.158417834150426 0.0959870131826345 0.3570874974893 0.0709632320696086 0 0 0.203830781607454 0.0236544106898695 3.10719081319669 0.000745036972881362 0.00459497318102527 UP ENSG00000256651 RP11-144O23.8 - - - - - - - 12:10831074-10832016 0 0 1 7 2 11 0 0 0.0675977495438436 0.470449532493977 0.123084129183215 0.773291321214529 0.0225325831812812 0.455608327630574 -4.33770949526679 0.000748356086575077 0.00461313702428502 DOWN ENSG00000261342 AC006538.1 - - - - - - - 19:2727743-2729327 28 48 25 14 17 11 1.24959370567667 1.94687097778885 1.00594190898484 0.559830874760685 0.622503482328996 0.460071745050663 1.40080219748345 0.547468700713448 1.35540486009944 0.000751095387409176 0.00462811180510084 UP ENSG00000266066 POLRMTP1 polymerase (RNA) mitochondrial (DNA directed) pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:28865] - - - - - - 17:62136972-62140639 113 118 69 44 66 39 2.17918676345736 2.06813021955567 1.19972340928098 0.760276280394951 1.04431451003193 0.704879131265816 1.81568013076467 0.836489973897566 1.11808991128832 0.000760417566379644 0.00467686568329169 UP ENSG00000137642 SORL1 sortilin-related receptor, L(DLR class) A repeats containing [Source:HGNC Symbol;Acc:HGNC:11185] GO:0040011|GO:0032502|GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0033218|GO:0004872|GO:0009892|GO:0048523|GO:0032994|GO:0044877|GO:0034358|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0038023|GO:0048870|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0031224|GO:0005615|GO:0050793|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0060341|GO:0042277|GO:0045595|GO:0048468|GO:0006810|GO:1901360|GO:0010941|GO:0007275|GO:0060627|GO:0045596|GO:0034641|GO:0044281|GO:0031982|GO:0051128|GO:0022607|GO:0051098|GO:0005887|GO:0043231|GO:0090083|GO:2001137|GO:0019899|GO:0004888|GO:0051651|GO:0005737|GO:0032880|GO:0051222|GO:0005635|GO:0006928|GO:0009966|GO:0045184|GO:0060548|GO:0032388|GO:0010646|GO:0031226|GO:0043085|GO:0008104|GO:0007154|GO:0044092|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0005783|GO:0009968|GO:0070062|GO:0051649|GO:0008219|GO:0090316|GO:1902966|GO:0050790|GO:0005641|GO:0043086|GO:0048869|GO:0016021|GO:2000145|GO:0010876|GO:0034362|GO:0019538|GO:0043254|GO:0023014|GO:0031324|GO:0031323|GO:0005794|GO:0005768|GO:0050768|GO:0000165|GO:0016192|GO:0032268|GO:0045732|GO:0031333|GO:1901215|GO:0005802|GO:0006518|GO:0051100|GO:0043412|GO:0072594|GO:0030163|GO:0005769|GO:0006066|GO:0070863|GO:0071813|GO:0032386|GO:0070997|GO:0010721|GO:0051223|GO:0051604|GO:0015031|GO:0030334|GO:2001135|GO:0051347|GO:0036211|GO:0032269|GO:0070201|GO:0046907|GO:0055037|GO:0032459|GO:0006869|GO:1902954|GO:0032507|GO:0051247|GO:0051346|GO:0006508|GO:0006461|GO:1901214|GO:0034613|GO:0008202|GO:0006796|GO:0043603|GO:0035556|GO:0042982|GO:0005795|GO:0044267|GO:0051174|GO:0042176|GO:0010467|GO:0007399|GO:1902532|GO:0060628|GO:0051246|GO:0051020|GO:0030154|GO:1903827|GO:1902531|GO:0005634|GO:0090084|GO:0000042|GO:0051960|GO:0001540|GO:0043393|GO:0006623|GO:0072600|GO:0010466|GO:1902953|GO:0033365|GO:0033157|GO:1902430|GO:0051259|GO:0043408|GO:0032456|GO:0032527|GO:1902955|GO:0014909|GO:0030162|GO:1902992|GO:0042987|GO:0016310|GO:0006605|GO:0014910|GO:0052547|GO:0048193|GO:0031985|GO:0016482|GO:0006886|GO:1902997|GO:0016197|GO:0031267|GO:0050435|GO:0045053|GO:0032460|GO:0016125|GO:0030169|GO:0045861|GO:0043409|GO:1902003|GO:0033673|GO:0006622|GO:0072666|GO:0006897|GO:1902771|GO:0022008|GO:0006464|GO:0050767|GO:0007034|GO:0032091|GO:0043549|GO:1902991|GO:0061502|GO:1902960|GO:1902959|GO:0045859|GO:1902963|GO:0034205|GO:0006469|GO:0007041|GO:0034067|GO:0006468|GO:0043407|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0010951|GO:0042326|GO:0006898|GO:0070861|GO:0008203|GO:0030306|GO:0001933|GO:0036010|GO:0006892|GO:0006888|GO:0006891|GO:0052548|GO:0071901|GO:0061462|GO:0000301|GO:1902946|GO:1902948|GO:0071900|GO:1902947 locomotion|developmental process|macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|amide binding|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|protein-lipid complex|macromolecular complex binding|plasma lipoprotein particle|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|signaling receptor activity|cell motility|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|extracellular space|regulation of developmental process|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cellular localization|peptide binding|regulation of cell differentiation|cell development|transport|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|regulation of vesicle-mediated transport|negative regulation of cell differentiation|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|regulation of cellular component organization|cellular component assembly|regulation of binding|integral component of plasma membrane|intracellular membrane-bounded organelle|regulation of inclusion body assembly|positive regulation of endocytic recycling|enzyme binding|transmembrane signaling receptor activity|maintenance of location in cell|cytoplasm|regulation of protein localization|positive regulation of protein transport|nuclear envelope|movement of cell or subcellular component|regulation of signal transduction|establishment of protein localization|negative regulation of cell death|positive regulation of intracellular transport|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|protein localization|cell communication|negative regulation of molecular function|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|endoplasmic reticulum|negative regulation of signal transduction|extracellular exosome|establishment of localization in cell|cell death|positive regulation of intracellular protein transport|positive regulation of protein localization to early endosome|regulation of catalytic activity|nuclear envelope lumen|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|regulation of cell motility|lipid localization|low-density lipoprotein particle|protein metabolic process|regulation of protein complex assembly|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|endosome|negative regulation of neurogenesis|MAPK cascade|vesicle-mediated transport|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|negative regulation of protein complex assembly|negative regulation of neuron death|trans-Golgi network|peptide metabolic process|negative regulation of binding|macromolecule modification|establishment of protein localization to organelle|protein catabolic process|early endosome|alcohol metabolic process|positive regulation of protein exit from endoplasmic reticulum|lipoprotein particle binding|regulation of intracellular transport|neuron death|negative regulation of cell development|regulation of protein transport|protein maturation|protein transport|regulation of cell migration|regulation of endocytic recycling|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|regulation of establishment of protein localization|intracellular transport|recycling endosome|regulation of protein oligomerization|lipid transport|regulation of early endosome to recycling endosome transport|maintenance of protein location in cell|positive regulation of protein metabolic process|negative regulation of hydrolase activity|proteolysis|protein complex assembly|regulation of neuron death|cellular protein localization|steroid metabolic process|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|amyloid precursor protein metabolic process|Golgi stack|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein catabolic process|gene expression|nervous system development|negative regulation of intracellular signal transduction|regulation of ER to Golgi vesicle-mediated transport|regulation of protein metabolic process|GTPase binding|cell differentiation|regulation of cellular protein localization|regulation of intracellular signal transduction|nucleus|negative regulation of inclusion body assembly|protein targeting to Golgi|regulation of nervous system development|beta-amyloid binding|regulation of protein binding|protein targeting to vacuole|establishment of protein localization to Golgi|negative regulation of peptidase activity|positive regulation of ER to Golgi vesicle-mediated transport|protein localization to organelle|regulation of intracellular protein transport|negative regulation of beta-amyloid formation|protein oligomerization|regulation of MAPK cascade|endocytic recycling|protein exit from endoplasmic reticulum|positive regulation of early endosome to recycling endosome transport|smooth muscle cell migration|regulation of proteolysis|negative regulation of amyloid precursor protein catabolic process|amyloid precursor protein catabolic process|phosphorylation|protein targeting|regulation of smooth muscle cell migration|regulation of peptidase activity|Golgi vesicle transport|Golgi cisterna|cytosolic transport|intracellular protein transport|negative regulation of neurofibrillary tangle assembly|endosomal transport|small GTPase binding|beta-amyloid metabolic process|protein retention in Golgi apparatus|negative regulation of protein oligomerization|sterol metabolic process|low-density lipoprotein particle binding|negative regulation of proteolysis|negative regulation of MAPK cascade|regulation of beta-amyloid formation|negative regulation of kinase activity|protein targeting to lysosome|establishment of protein localization to vacuole|endocytosis|positive regulation of choline O-acetyltransferase activity|neurogenesis|cellular protein modification process|regulation of neurogenesis|vacuolar transport|negative regulation of protein binding|regulation of kinase activity|regulation of amyloid precursor protein catabolic process|early endosome to recycling endosome transport|negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process|regulation of protein kinase activity|negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process|beta-amyloid formation|negative regulation of protein kinase activity|lysosomal transport|protein localization to Golgi apparatus|protein phosphorylation|negative regulation of MAP kinase activity|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of endopeptidase activity|negative regulation of phosphorylation|receptor-mediated endocytosis|regulation of protein exit from endoplasmic reticulum|cholesterol metabolic process|ADP-ribosylation factor binding|negative regulation of protein phosphorylation|protein localization to endosome|post-Golgi vesicle-mediated transport|ER to Golgi vesicle-mediated transport|intra-Golgi vesicle-mediated transport|regulation of endopeptidase activity|negative regulation of protein serine/threonine kinase activity|protein localization to lysosome|retrograde transport, vesicle recycling within Golgi|protein localization to early endosome|negative regulation of tau-protein kinase activity|regulation of protein serine/threonine kinase activity|regulation of tau-protein kinase activity - - - - 11:121452203-121633693 47 39 176 215 201 451 0.148328861913804 0.11186023046942 0.50078835361857 0.607941573297007 0.520462754845081 1.33392560690292 0.253659148667265 0.820776645015003 -1.6940984852547 0.000761983642649849 0.0046845674768675 DOWN ENSG00000245958 RP11-33B1.1 - - - - - - - 4:119454791-119552025 62 76 105 149 164 197 0.536212212450535 0.597363364471119 0.818746618018165 1.15459817905174 1.1637416197652 1.59676167314705 0.65077406497994 1.305033823988 -1.00385853702274 0.000762986255557716 0.00468976563175212 DOWN ENSG00000164659 KIAA1324L KIAA1324-like [Source:HGNC Symbol;Acc:HGNC:21945] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 7:86876906-87059699 61 72 141 183 180 282 0.365150144127884 0.391697194693493 0.760977550334139 0.981491009450153 0.884052424470394 1.58203497074382 0.505941629718505 1.14919280155479 -1.1835780046048 0.000764553510619355 0.00469843155743726 DOWN ENSG00000122912 SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 [Source:HGNC Symbol;Acc:HGNC:10986] GO:0005215|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0022857|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003735|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0006575|GO:0019866|GO:0006810|GO:0006082|GO:0034641|GO:0044281|GO:0043231|GO:0005737|GO:0031966|GO:0051186|GO:0055085|GO:0016021|GO:0044249|GO:0019538|GO:0005740|GO:0034645|GO:0006518|GO:0005743|GO:0015939|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0006766|GO:0043043|GO:0015297|GO:0009108|GO:0006412|GO:0019752|GO:0006767|GO:0032787 transporter activity|structural molecule activity|cell|membrane|cellular process|metabolic process|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|cellular modified amino acid metabolic process|organelle inner membrane|transport|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|cofactor metabolic process|transmembrane transport|integral component of membrane|cellular biosynthetic process|protein metabolic process|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|mitochondrial inner membrane|pantothenate metabolic process|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|vitamin metabolic process|peptide biosynthetic process|antiporter activity|coenzyme biosynthetic process|translation|carboxylic acid metabolic process|water-soluble vitamin metabolic process|monocarboxylic acid metabolic process - - - - 10:68477999-68527474 52 71 67 166 175 96 0.326818663363063 0.405546767860667 0.379656096068343 0.934770042066841 0.902417212447062 0.565455996491813 0.370673842430691 0.800881083668572 -1.11143773325982 0.000772262979785867 0.00473995456384195 DOWN ENSG00000079931 MOXD1 monooxygenase, DBH-like 1 [Source:HGNC Symbol;Acc:HGNC:21063] GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0042175|GO:0043167|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0004497|GO:0005783|GO:0016021|GO:0055114|GO:0046872|GO:0016715|GO:0046914|GO:0005507 cell|membrane|metabolic process|binding|catalytic activity|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|endoplasmic reticulum|integral component of membrane|oxidation-reduction process|metal ion binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen|transition metal ion binding|copper ion binding - - - - 6:132296055-132401545 3 11 18 32 25 63 0.0299638316135739 0.0998433922811851 0.162078912316934 0.286336745052473 0.204848419422638 0.589650653120013 0.097295378737231 0.360278605865041 -1.88866979620623 0.000772646173189794 0.0047407177062192 DOWN ENSG00000144668 ITGA9 integrin subunit alpha 9 [Source:HGNC Symbol;Acc:HGNC:6145] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0045178|GO:0050840|GO:0044877|GO:0050794|GO:0006950|GO:0050900|GO:0043167|GO:0048870|GO:0009653|GO:0016043|GO:0007155|GO:0071944|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0006935|GO:0048468|GO:0016323|GO:0009925|GO:0098797|GO:0007275|GO:0043062|GO:0005887|GO:0043169|GO:0009611|GO:0043235|GO:0006928|GO:0032403|GO:0031226|GO:0007154|GO:0016477|GO:0007165|GO:0043236|GO:0030595|GO:0030030|GO:0048869|GO:0016021|GO:0000902|GO:0031175|GO:0046872|GO:0007166|GO:0005518|GO:0000904|GO:0042060|GO:0060326|GO:0008305|GO:0032990|GO:0007399|GO:0097485|GO:0030198|GO:0030154|GO:0048858|GO:0071621|GO:0048666|GO:0030182|GO:0007411|GO:1990266|GO:0034679|GO:0007229|GO:0030593|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0007409|GO:0048699 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|basal part of cell|extracellular matrix binding|macromolecular complex binding|regulation of cellular process|response to stress|leukocyte migration|ion binding|cell motility|anatomical structure morphogenesis|cellular component organization|cell adhesion|cell periphery|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|protein complex|anatomical structure development|chemotaxis|cell development|basolateral plasma membrane|basal plasma membrane|plasma membrane protein complex|multicellular organism development|extracellular structure organization|integral component of plasma membrane|cation binding|response to wounding|receptor complex|movement of cell or subcellular component|protein complex binding|intrinsic component of plasma membrane|cell communication|cell migration|signal transduction|laminin binding|leukocyte chemotaxis|cell projection organization|cellular developmental process|integral component of membrane|cell morphogenesis|neuron projection development|metal ion binding|cell surface receptor signaling pathway|collagen binding|cell morphogenesis involved in differentiation|wound healing|cell chemotaxis|integrin complex|cell part morphogenesis|nervous system development|neuron projection guidance|extracellular matrix organization|cell differentiation|cell projection morphogenesis|granulocyte chemotaxis|neuron development|neuron differentiation|axon guidance|neutrophil migration|integrin alpha9-beta1 complex|integrin-mediated signaling pathway|neutrophil chemotaxis|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|axonogenesis|generation of neurons K06585 integrin alpha 9[-] hsa04151|hsa04810|hsa04510|hsa04514|hsa05414|hsa05410|hsa04512|hsa05412 PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Cell adhesion molecules (CAMs) - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 3:37452115-37823514 2 1 4 10 11 13 0.0147330895538773 0.00669836770849191 0.0265686531958815 0.0660079698050768 0.0664866586839419 0.0897579382848509 0.0160000368194169 0.0740841889246232 -2.21109044980781 0.000776244321565782 0.00476047616598703 DOWN ENSG00000176907 C8orf4 chromosome 8 open reading frame 4 [Source:HGNC Symbol;Acc:HGNC:1357] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:1903829|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:0051726|GO:0007049|GO:1903706|GO:0002264|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0005737|GO:0032880|GO:0009408|GO:0051222|GO:0001775|GO:0009966|GO:0002263|GO:0045184|GO:0032388|GO:0010646|GO:0006139|GO:1900182|GO:0008104|GO:0007154|GO:0007165|GO:0009968|GO:0051649|GO:0008219|GO:0090316|GO:0009967|GO:0044249|GO:0009266|GO:0031323|GO:0005112|GO:1902533|GO:0005730|GO:0042307|GO:0010468|GO:0034645|GO:0007166|GO:0072594|GO:0030097|GO:0043620|GO:0051252|GO:0032386|GO:0044770|GO:0051223|GO:0015031|GO:0070201|GO:0046907|GO:0042886|GO:0031981|GO:0010564|GO:0034605|GO:0008593|GO:0005654|GO:1904591|GO:0034613|GO:0012501|GO:0035556|GO:0010467|GO:0017038|GO:0031503|GO:0009059|GO:0042118|GO:1903827|GO:1902531|GO:0016070|GO:0005634|GO:0006606|GO:0045746|GO:1904589|GO:0033365|GO:0033157|GO:0043122|GO:0051169|GO:0032774|GO:2001141|GO:0015833|GO:0006605|GO:0016604|GO:0016482|GO:0006886|GO:0043123|GO:0007249|GO:0042993|GO:1901987|GO:0042306|GO:0042345|GO:1900180|GO:0007219|GO:0042991|GO:0006351|GO:0006915|GO:0006355|GO:0046824|GO:0016607|GO:1903533|GO:0006913|GO:0042346|GO:1903506|GO:1902806|GO:0042990|GO:0034504|GO:0046822|GO:0051170 developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|positive regulation of cellular protein localization|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|regulation of cell cycle|cell cycle|regulation of hemopoiesis|endothelial cell activation involved in immune response|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|response to heat|positive regulation of protein transport|cell activation|regulation of signal transduction|cell activation involved in immune response|establishment of protein localization|positive regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of protein localization to nucleus|protein localization|cell communication|signal transduction|negative regulation of signal transduction|establishment of localization in cell|cell death|positive regulation of intracellular protein transport|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|regulation of cellular metabolic process|Notch binding|positive regulation of intracellular signal transduction|nucleolus|positive regulation of protein import into nucleus|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|establishment of protein localization to organelle|hemopoiesis|regulation of DNA-templated transcription in response to stress|regulation of RNA metabolic process|regulation of intracellular transport|cell cycle phase transition|regulation of protein transport|protein transport|regulation of establishment of protein localization|intracellular transport|amide transport|nuclear lumen|regulation of cell cycle process|cellular response to heat|regulation of Notch signaling pathway|nucleoplasm|positive regulation of protein import|cellular protein localization|programmed cell death|intracellular signal transduction|gene expression|protein import|protein complex localization|macromolecule biosynthetic process|endothelial cell activation|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|nucleus|protein import into nucleus|negative regulation of Notch signaling pathway|regulation of protein import|protein localization to organelle|regulation of intracellular protein transport|regulation of I-kappaB kinase/NF-kappaB signaling|nuclear transport|RNA biosynthetic process|regulation of RNA biosynthetic process|peptide transport|protein targeting|nuclear body|cytosolic transport|intracellular protein transport|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|positive regulation of transcription factor import into nucleus|regulation of cell cycle phase transition|regulation of protein import into nucleus|regulation of NF-kappaB import into nucleus|regulation of protein localization to nucleus|Notch signaling pathway|transcription factor import into nucleus|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of nucleocytoplasmic transport|nuclear speck|regulation of protein targeting|nucleocytoplasmic transport|positive regulation of NF-kappaB import into nucleus|regulation of nucleic acid-templated transcription|regulation of cell cycle G1/S phase transition|regulation of transcription factor import into nucleus|protein localization to nucleus|regulation of nucleocytoplasmic transport|nuclear import - - - - 8:40153455-40155308 124 111 147 250 218 337 4.73104604706896 3.84893255417184 5.05670982970809 8.54622449083728 6.82433668100815 12.0502248448258 4.5455628103163 9.14026200555708 -1.00777658749339 0.000780466753763252 0.00478440543467107 DOWN ENSG00000099139 PCSK5 proprotein convertase subtilisin/kexin type 5 [Source:HGNC Symbol;Acc:HGNC:8747] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0033218|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0044237|GO:0042445|GO:0009653|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0016032|GO:0007507|GO:0048565|GO:0003014|GO:0042277|GO:0001822|GO:0006810|GO:0035295|GO:0001568|GO:0007275|GO:0048513|GO:0034641|GO:0032940|GO:0031982|GO:0007566|GO:0030141|GO:0043231|GO:0008233|GO:0005737|GO:0007389|GO:0001816|GO:0007267|GO:0016486|GO:0048568|GO:0045184|GO:0030323|GO:0008104|GO:0007154|GO:0007565|GO:0007165|GO:0003279|GO:0008217|GO:0010817|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0003013|GO:0005794|GO:0017171|GO:0003205|GO:0042107|GO:0042089|GO:0006518|GO:0055123|GO:0007166|GO:0003071|GO:0001944|GO:0072358|GO:0031410|GO:0001655|GO:0060976|GO:0051604|GO:0015031|GO:0009790|GO:0016023|GO:0072001|GO:0005796|GO:0003002|GO:0009306|GO:0070848|GO:0006508|GO:0031988|GO:0008236|GO:0043603|GO:0035108|GO:0044267|GO:0010467|GO:0046903|GO:0019058|GO:0071310|GO:0001501|GO:0060173|GO:0032455|GO:0048566|GO:0072359|GO:0008015|GO:0003073|GO:0048706|GO:0004252|GO:0043043|GO:0009792|GO:0016485|GO:0003081|GO:0071363|GO:0038179|GO:0002001|GO:0007167|GO:0004175|GO:0009855|GO:0009952|GO:0006465|GO:0048011|GO:0007368|GO:0001991|GO:0043009|GO:0007169 developmental process|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|amide binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|cellular metabolic process|hormone metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|extracellular space|intracellular|protein binding|endomembrane system|anatomical structure development|viral process|heart development|digestive tract development|renal system process|peptide binding|kidney development|transport|tube development|blood vessel development|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|secretion by cell|vesicle|embryo implantation|secretory granule|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|pattern specification process|cytokine production|cell-cell signaling|peptide hormone processing|embryonic organ development|establishment of protein localization|respiratory tube development|protein localization|cell communication|female pregnancy|signal transduction|cardiac septum development|regulation of blood pressure|regulation of hormone levels|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|circulatory system process|Golgi apparatus|serine hydrolase activity|cardiac chamber development|cytokine metabolic process|cytokine biosynthetic process|peptide metabolic process|digestive system development|cell surface receptor signaling pathway|renal system process involved in regulation of systemic arterial blood pressure|vasculature development|cardiovascular system development|cytoplasmic vesicle|urogenital system development|coronary vasculature development|protein maturation|protein transport|embryo development|cytoplasmic, membrane-bounded vesicle|renal system development|Golgi lumen|regionalization|protein secretion|response to growth factor|proteolysis|membrane-bounded vesicle|serine-type peptidase activity|cellular amide metabolic process|limb morphogenesis|cellular protein metabolic process|gene expression|secretion|viral life cycle|cellular response to organic substance|skeletal system development|limb development|nerve growth factor processing|embryonic digestive tract development|circulatory system development|blood circulation|regulation of systemic arterial blood pressure|embryonic skeletal system development|serine-type endopeptidase activity|peptide biosynthetic process|embryo development ending in birth or egg hatching|protein processing|regulation of systemic arterial blood pressure by renin-angiotensin|cellular response to growth factor stimulus|neurotrophin signaling pathway|renin secretion into blood stream|enzyme linked receptor protein signaling pathway|endopeptidase activity|determination of bilateral symmetry|anterior/posterior pattern specification|signal peptide processing|neurotrophin TRK receptor signaling pathway|determination of left/right symmetry|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|chordate embryonic development|transmembrane receptor protein tyrosine kinase signaling pathway - - - - 9:75890644-76362339 30 40 68 113 99 104 0.140879847931611 0.170715799187597 0.287909051255994 0.475457208446535 0.381448603388884 0.457715177606553 0.199834899458401 0.438206996480657 -1.13280395930353 0.000785871507846253 0.0048145717207556 DOWN ENSG00000278330 RP11-4B16.4 - - - - - - - 18:77112602-77115726 7 3 6 21 16 22 0.126479711650474 0.0492700717484236 0.0977441409911318 0.339965733240742 0.237191517728507 0.372540983029631 0.0911646414633431 0.316566077999627 -1.79596038663322 0.000788710112529591 0.00482997983578634 DOWN ENSG00000260005 AC027601.1 - - - - - - - 17:81228707-81233983 49 51 54 27 29 25 0.675523335964204 0.638994899764259 0.671204065380782 0.333512173314854 0.328021442683705 0.323008221534624 0.661907433703082 0.328180612511061 1.01213946021898 0.000789118411995502 0.00483049847687384 UP ENSG00000260400 RP11-119F7.5 - - - - - - - 10:68698500-68700794 10 9 12 4 1 2 0.308207245961504 0.252120323908277 0.333480010440332 0.110467716961803 0.0252998813003714 0.0577653554489918 0.297935860103371 0.0645109845703887 2.20738503881966 0.000789816271572306 0.00483377920695359 UP ENSG00000159885 ZNF222 zinc finger protein 222 [Source:HGNC Symbol;Acc:HGNC:13015] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:44025342-44033112 111 137 97 55 43 78 2.17080174798597 2.43499884144053 1.71034121448628 0.963740867032856 0.6899680620673 1.42961647503888 2.10538060130426 1.02777513471301 1.03455640673246 0.000791073143656574 0.00484047912086972 UP ENSG00000204529 GUCY2EP guanylate cyclase 2E, pseudogene [Source:HGNC Symbol;Acc:HGNC:4690] - - - - - - 11:76694043-76707641 1 0 3 5 7 22 0.0501180548318795 0 0.135482140094385 0.224413742158747 0.287725374676818 1.03293055847097 0.0618667316420882 0.515023225102178 -3.05740176752646 0.000795631041733246 0.00486737072129187 DOWN ENSG00000260571 BNIP3P5 BCL2/adenovirus E1B 19kDa interacting protein 3 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:39658] - - - - - - 15:42313687-42314386 0 0 0 6 4 3 0 0 0 0.763624730202828 0.466137886826392 0.39931171914288 0 0.543024778724033 -Inf 0.000796132379482767 0.00486844245331391 DOWN ENSG00000158373 HIST1H2BD histone cluster 1, H2bd [Source:HGNC Symbol;Acc:HGNC:4747] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0097159|GO:0043229|GO:0000785|GO:0016043|GO:0043227|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0003676|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0046983|GO:0000790|GO:0070062|GO:0000786|GO:0006996|GO:0051276|GO:0003677|GO:0046982|GO:0006325|GO:0000788|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0005634|GO:0006334|GO:0034622|GO:0034728|GO:0006333|GO:0065004|GO:0031497|GO:0071103|GO:0006323 macromolecular complex|cell|cellular process|extracellular region|binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|chromatin|cellular component organization|membrane-bounded organelle|protein-DNA complex|intracellular|protein binding|protein complex|nucleic acid binding|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|nuclear chromatin|extracellular exosome|nucleosome|organelle organization|chromosome organization|DNA binding|protein heterodimerization activity|chromatin organization|nuclear nucleosome|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|nucleus|nucleosome assembly|cellular macromolecular complex assembly|nucleosome organization|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|DNA conformation change|DNA packaging K11252 histone H2B[-] hsa05203|hsa05034|hsa05322 Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 6:26158146-26171349 130 120 299 356 361 551 7.15623404587926 6.00348346263684 14.8397952796609 17.5586102019367 16.304870215967 28.4264819392208 9.33317092939233 20.7633207857082 -1.15359797713069 0.000797114972726217 0.00487345287646293 DOWN ENSG00000120251 GRIA2 glutamate receptor, ionotropic, AMPA 2 [Source:HGNC Symbol;Acc:HGNC:4572] GO:0032991|GO:0004871|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0022857|GO:0050794|GO:0043229|GO:0042175|GO:0038023|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0097060|GO:0031090|GO:0030594|GO:0006810|GO:0098797|GO:0031982|GO:0045211|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0007267|GO:0012506|GO:0043235|GO:0030666|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0005783|GO:0016021|GO:0008328|GO:0007166|GO:0031410|GO:0016023|GO:0015267|GO:0006811|GO:0015075|GO:0031988|GO:0008066|GO:0034702|GO:0030659|GO:0034220|GO:0015276|GO:0005216|GO:0022824|GO:0007215|GO:0030139|GO:0004970|GO:0032281|GO:0004971|GO:0035235|GO:0005230|GO:0007268|GO:0005231|GO:0005234 macromolecular complex|signal transducer activity|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|receptor activity|transmembrane transporter activity|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|signaling receptor activity|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|synaptic membrane|organelle membrane|neurotransmitter receptor activity|transport|plasma membrane protein complex|vesicle|postsynaptic membrane|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|vesicle membrane|receptor complex|endocytic vesicle membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|endoplasmic reticulum|integral component of membrane|ionotropic glutamate receptor complex|cell surface receptor signaling pathway|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|channel activity|ion transport|ion transmembrane transporter activity|membrane-bounded vesicle|glutamate receptor activity|ion channel complex|cytoplasmic vesicle membrane|ion transmembrane transport|ligand-gated ion channel activity|ion channel activity|transmitter-gated ion channel activity|glutamate receptor signaling pathway|endocytic vesicle|ionotropic glutamate receptor activity|AMPA glutamate receptor complex|AMPA glutamate receptor activity|ionotropic glutamate receptor signaling pathway|extracellular ligand-gated ion channel activity|synaptic transmission|excitatory extracellular ligand-gated ion channel activity|extracellular-glutamate-gated ion channel activity K05198 glutamate receptor 2[-] hsa04080|hsa04024|hsa04728|hsa04724|hsa04723|hsa04713|hsa05031|hsa04720|hsa04730|hsa05014|hsa05030|hsa05033 Neuroactive ligand-receptor interaction - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human)|Nicotine addiction - Homo sapiens (human) 4:157204182-157366075 0 1 2 3 8 19 0 0.00400234765008957 0.00793752980668494 0.0118301492666137 0.0288943034616067 0.0783802237509301 0.00397995915225817 0.0397015588263835 -3.31837012482749 0.000798424003880071 0.00488045663632999 DOWN ENSG00000260772 RP11-311C24.1 - - - - - - - 16:69703065-69704652 204 23 31 17 11 25 9.08709663155834 0.931132476370572 1.24501652249449 0.678490198495068 0.402018196903785 1.04367454955552 3.75441521014113 0.708060981651458 2.40664268755724 0.000802155606998894 0.00490025649505729 UP ENSG00000091831 ESR1 estrogen receptor 1 [Source:HGNC Symbol;Acc:HGNC:3467] GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0000003|GO:0045202|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0042995|GO:0097159|GO:0004872|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0042562|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0042698|GO:0051051|GO:0044237|GO:0042445|GO:0038023|GO:0003006|GO:0023051|GO:0044297|GO:0009653|GO:0000785|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0004879|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0030234|GO:0050793|GO:0048589|GO:0005622|GO:0022602|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0048609|GO:0019222|GO:0042802|GO:0098531|GO:0045137|GO:0001893|GO:0008284|GO:0046697|GO:1903409|GO:0042127|GO:0044255|GO:0008209|GO:0001890|GO:0060745|GO:0035239|GO:0006725|GO:0003707|GO:0009888|GO:0008013|GO:0048468|GO:0043025|GO:0006810|GO:0035295|GO:1901360|GO:0043195|GO:0010941|GO:0007275|GO:0003676|GO:0005496|GO:0048513|GO:0060065|GO:0005102|GO:0034641|GO:2001057|GO:0031325|GO:0046483|GO:0060687|GO:0001547|GO:0035265|GO:0060009|GO:0030315|GO:0043231|GO:0060740|GO:0048608|GO:0001541|GO:0043169|GO:0019899|GO:0048144|GO:0005737|GO:0000981|GO:0001763|GO:0061377|GO:1990375|GO:0060512|GO:0009887|GO:0032403|GO:0042592|GO:0072593|GO:0060749|GO:0043005|GO:0009966|GO:0048729|GO:0043204|GO:0007548|GO:0050673|GO:0009890|GO:0042383|GO:0019725|GO:0036477|GO:0003682|GO:0060135|GO:0060008|GO:0060548|GO:0010646|GO:0006139|GO:0038052|GO:0043085|GO:0000790|GO:0030235|GO:0008406|GO:0007154|GO:0044092|GO:0007565|GO:0006629|GO:0007165|GO:0009968|GO:0001503|GO:0008134|GO:0009725|GO:0044306|GO:0008219|GO:0060348|GO:0008285|GO:0050790|GO:0010829|GO:0060688|GO:0043548|GO:0060011|GO:0045833|GO:0010817|GO:0048869|GO:0016021|GO:0048806|GO:0035327|GO:0009967|GO:0044249|GO:0030850|GO:0019538|GO:0023014|GO:0010033|GO:0060736|GO:0031324|GO:0031323|GO:0048732|GO:0005794|GO:0006996|GO:0051090|GO:0060560|GO:0000165|GO:0090207|GO:0050679|GO:0051276|GO:0000982|GO:1902533|GO:0032268|GO:0005829|GO:0003677|GO:0090209|GO:0007186|GO:0030879|GO:0030540|GO:0010468|GO:0034645|GO:0048660|GO:1901215|GO:0008584|GO:0046486|GO:0036312|GO:0046872|GO:0007166|GO:0002009|GO:0033993|GO:0030424|GO:0043412|GO:0008585|GO:0046661|GO:0061458|GO:0051345|GO:0001655|GO:0010629|GO:0002064|GO:0048878|GO:0051252|GO:0006325|GO:0051117|GO:0070997|GO:0048754|GO:0048659|GO:0061138|GO:0022612|GO:0046545|GO:0010628|GO:0060442|GO:0036211|GO:2000377|GO:2000027|GO:0055082|GO:0046209|GO:0001649|GO:1903428|GO:0051091|GO:0043679|GO:0048145|GO:0006638|GO:0031981|GO:1901184|GO:0051247|GO:0048146|GO:0048471|GO:0045428|GO:0005654|GO:0001664|GO:0005739|GO:0043433|GO:0050678|GO:0030284|GO:0005694|GO:0000228|GO:1901214|GO:0051353|GO:0001221|GO:0008202|GO:0051341|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0003401|GO:0060562|GO:0019216|GO:0071310|GO:1902532|GO:0031328|GO:0006809|GO:0051246|GO:0060523|GO:0009059|GO:0030154|GO:0009755|GO:0001501|GO:0001228|GO:1902531|GO:0016070|GO:0008643|GO:0046325|GO:0032870|GO:1901186|GO:0010557|GO:0005634|GO:0033598|GO:0043067|GO:0048662|GO:0048545|GO:0097305|GO:0035254|GO:1903426|GO:0002076|GO:0030522|GO:0046546|GO:0010827|GO:2000379|GO:0060068|GO:0060602|GO:0043401|GO:0001223|GO:0000975|GO:0045893|GO:0043124|GO:0007200|GO:0031401|GO:0043122|GO:0045742|GO:0030855|GO:0060603|GO:0043408|GO:0045892|GO:0043523|GO:0060444|GO:0032770|GO:0042058|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0046324|GO:0016310|GO:0043627|GO:1902679|GO:0070371|GO:0071383|GO:0035256|GO:0071407|GO:0003690|GO:0030518|GO:0007167|GO:0060527|GO:0007249|GO:0043410|GO:0032355|GO:0042981|GO:0045429|GO:0046914|GO:0050801|GO:0016568|GO:0051402|GO:0006639|GO:0006464|GO:0061180|GO:0071396|GO:0060443|GO:0060193|GO:0006351|GO:0060750|GO:0006915|GO:0006355|GO:0006873|GO:0051000|GO:0030520|GO:0045944|GO:0006366|GO:1903507|GO:0008645|GO:0006352|GO:0006357|GO:0010517|GO:0006468|GO:0031798|GO:1903506|GO:0044212|GO:0042325|GO:0070374|GO:0001932|GO:0071392|GO:0050999|GO:0001934|GO:0071391|GO:0010518|GO:0006338|GO:0070372|GO:0008270|GO:0030003|GO:0042327|GO:0006641|GO:0060751|GO:0007169|GO:0006367|GO:0010863|GO:0034056|GO:0001047|GO:0000976|GO:0015758|GO:0055065|GO:0001012|GO:0006875|GO:0001159|GO:0038127|GO:0046323|GO:0001046|GO:0007173|GO:0006874|GO:0000977|GO:0000987|GO:0055074|GO:0051480|GO:0000978|GO:0007204 developmental process|growth|macromolecular complex|signal transducer activity|reproduction|synapse|signaling|cell|rhythmic process|membrane|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|cell projection|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|hormone binding|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|ovulation cycle|negative regulation of transport|cellular metabolic process|hormone metabolic process|signaling receptor activity|developmental process involved in reproduction|regulation of signaling|cell body|anatomical structure morphogenesis|chromatin|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|regulation of developmental process|developmental growth|intracellular|ovulation cycle process|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|identical protein binding|transcription factor activity, direct ligand regulated sequence-specific DNA binding|development of primary sexual characteristics|maternal placenta development|positive regulation of cell proliferation|decidualization|reactive oxygen species biosynthetic process|regulation of cell proliferation|cellular lipid metabolic process|androgen metabolic process|placenta development|mammary gland branching involved in pregnancy|tube morphogenesis|cellular aromatic compound metabolic process|steroid hormone receptor activity|tissue development|beta-catenin binding|cell development|neuronal cell body|transport|tube development|organic cyclic compound metabolic process|terminal bouton|regulation of cell death|multicellular organism development|nucleic acid binding|steroid binding|animal organ development|uterus development|receptor binding|cellular nitrogen compound metabolic process|reactive nitrogen species metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of branching involved in prostate gland morphogenesis|antral ovarian follicle growth|organ growth|Sertoli cell development|T-tubule|intracellular membrane-bounded organelle|prostate gland epithelium morphogenesis|reproductive structure development|ovarian follicle development|cation binding|enzyme binding|fibroblast proliferation|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|morphogenesis of a branching structure|mammary gland lobule development|baculum development|prostate gland morphogenesis|organ morphogenesis|protein complex binding|homeostatic process|reactive oxygen species metabolic process|mammary gland alveolus development|neuron projection|regulation of signal transduction|tissue morphogenesis|perikaryon|sex differentiation|epithelial cell proliferation|negative regulation of biosynthetic process|sarcolemma|cellular homeostasis|somatodendritic compartment|chromatin binding|maternal process involved in female pregnancy|Sertoli cell differentiation|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding|positive regulation of catalytic activity|nuclear chromatin|nitric-oxide synthase regulator activity|gonad development|cell communication|negative regulation of molecular function|female pregnancy|lipid metabolic process|signal transduction|negative regulation of signal transduction|ossification|transcription factor binding|response to hormone|neuron projection terminus|cell death|bone development|negative regulation of cell proliferation|regulation of catalytic activity|negative regulation of glucose transport|regulation of morphogenesis of a branching structure|phosphatidylinositol 3-kinase binding|Sertoli cell proliferation|negative regulation of lipid metabolic process|regulation of hormone levels|cellular developmental process|integral component of membrane|genitalia development|transcriptionally active chromatin|positive regulation of signal transduction|cellular biosynthetic process|prostate gland development|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|prostate gland growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|Golgi apparatus|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|developmental growth involved in morphogenesis|MAPK cascade|regulation of triglyceride metabolic process|positive regulation of epithelial cell proliferation|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|DNA binding|negative regulation of triglyceride metabolic process|G-protein coupled receptor signaling pathway|mammary gland development|female genitalia development|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|negative regulation of neuron death|male gonad development|glycerolipid metabolic process|phosphatidylinositol 3-kinase regulatory subunit binding|metal ion binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|response to lipid|axon|macromolecule modification|female gonad development|male sex differentiation|reproductive system development|positive regulation of hydrolase activity|urogenital system development|negative regulation of gene expression|epithelial cell development|chemical homeostasis|regulation of RNA metabolic process|chromatin organization|ATPase binding|neuron death|branching morphogenesis of an epithelial tube|smooth muscle cell proliferation|morphogenesis of a branching epithelium|gland morphogenesis|development of primary female sexual characteristics|positive regulation of gene expression|branching involved in prostate gland morphogenesis|protein modification process|regulation of reactive oxygen species metabolic process|regulation of organ morphogenesis|cellular chemical homeostasis|nitric oxide metabolic process|osteoblast differentiation|positive regulation of reactive oxygen species biosynthetic process|positive regulation of sequence-specific DNA binding transcription factor activity|axon terminus|regulation of fibroblast proliferation|neutral lipid metabolic process|nuclear lumen|regulation of ERBB signaling pathway|positive regulation of protein metabolic process|positive regulation of fibroblast proliferation|perinuclear region of cytoplasm|regulation of nitric oxide biosynthetic process|nucleoplasm|G-protein coupled receptor binding|mitochondrion|negative regulation of sequence-specific DNA binding transcription factor activity|regulation of epithelial cell proliferation|estrogen receptor activity|chromosome|nuclear chromosome|regulation of neuron death|positive regulation of oxidoreductase activity|transcription cofactor binding|steroid metabolic process|regulation of oxidoreductase activity|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|axis elongation|epithelial tube morphogenesis|regulation of lipid metabolic process|cellular response to organic substance|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|prostate epithelial cord elongation|macromolecule biosynthetic process|cell differentiation|hormone-mediated signaling pathway|skeletal system development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|regulation of intracellular signal transduction|RNA metabolic process|carbohydrate transport|negative regulation of glucose import|cellular response to hormone stimulus|positive regulation of ERBB signaling pathway|positive regulation of macromolecule biosynthetic process|nucleus|mammary gland epithelial cell proliferation|regulation of programmed cell death|negative regulation of smooth muscle cell proliferation|response to steroid hormone|response to alcohol|glutamate receptor binding|regulation of reactive oxygen species biosynthetic process|osteoblast development|intracellular receptor signaling pathway|development of primary male sexual characteristics|regulation of glucose transport|positive regulation of reactive oxygen species metabolic process|vagina development|branch elongation of an epithelium|steroid hormone mediated signaling pathway|transcription coactivator binding|regulatory region DNA binding|positive regulation of transcription, DNA-templated|negative regulation of I-kappaB kinase/NF-kappaB signaling|phospholipase C-activating G-protein coupled receptor signaling pathway|positive regulation of protein modification process|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of epidermal growth factor receptor signaling pathway|epithelial cell differentiation|mammary gland duct morphogenesis|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|branching involved in mammary gland duct morphogenesis|positive regulation of monooxygenase activity|regulation of epidermal growth factor receptor signaling pathway|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of glucose import|phosphorylation|response to estrogen|negative regulation of RNA biosynthetic process|ERK1 and ERK2 cascade|cellular response to steroid hormone stimulus|G-protein coupled glutamate receptor binding|cellular response to organic cyclic compound|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|enzyme linked receptor protein signaling pathway|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|I-kappaB kinase/NF-kappaB signaling|positive regulation of MAPK cascade|response to estradiol|regulation of apoptotic process|positive regulation of nitric oxide biosynthetic process|transition metal ion binding|ion homeostasis|chromatin modification|neuron apoptotic process|acylglycerol metabolic process|cellular protein modification process|mammary gland epithelium development|cellular response to lipid|mammary gland morphogenesis|positive regulation of lipase activity|transcription, DNA-templated|epithelial cell proliferation involved in mammary gland duct elongation|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|positive regulation of nitric-oxide synthase activity|intracellular estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|hexose transport|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of phospholipase activity|protein phosphorylation|type 1 metabotropic glutamate receptor binding|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|cellular response to estradiol stimulus|regulation of nitric-oxide synthase activity|positive regulation of protein phosphorylation|cellular response to estrogen stimulus|positive regulation of phospholipase activity|chromatin remodeling|regulation of ERK1 and ERK2 cascade|zinc ion binding|cellular cation homeostasis|positive regulation of phosphorylation|triglyceride metabolic process|branch elongation involved in mammary gland duct branching|transmembrane receptor protein tyrosine kinase signaling pathway|transcription initiation from RNA polymerase II promoter|positive regulation of phospholipase C activity|estrogen response element binding|core promoter binding|transcription regulatory region sequence-specific DNA binding|glucose transport|metal ion homeostasis|RNA polymerase II regulatory region DNA binding|cellular metal ion homeostasis|core promoter proximal region DNA binding|ERBB signaling pathway|glucose import|core promoter sequence-specific DNA binding|epidermal growth factor receptor signaling pathway|cellular calcium ion homeostasis|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|RNA polymerase II core promoter proximal region sequence-specific DNA binding|positive regulation of cytosolic calcium ion concentration K08550 estrogen receptor alpha[-] hsa05205|hsa04919|hsa04915|hsa04917|hsa04961 Proteoglycans in cancer - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) 6:151656691-152129619 19 22 61 123 110 62 0.0784434031687145 0.082549503632728 0.227068292142002 0.455002412810743 0.37262728832539 0.239900182727563 0.129353732981148 0.355843294621232 -1.45992036168159 0.000813292868095798 0.00495713460272192 DOWN ENSG00000065534 MYLK myosin light chain kinase [Source:HGNC Symbol;Acc:HGNC:7590] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0040012|GO:0043229|GO:0051050|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009628|GO:0009986|GO:0044237|GO:0006914|GO:0048870|GO:0040017|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0031252|GO:0005622|GO:0002682|GO:0005515|GO:0016740|GO:0048856|GO:0048514|GO:0051272|GO:0009888|GO:0006810|GO:0001568|GO:0007275|GO:0050688|GO:0048513|GO:0043168|GO:0006952|GO:0001882|GO:0043270|GO:0016772|GO:0031982|GO:2000147|GO:0033554|GO:0022607|GO:0098542|GO:0061061|GO:0043169|GO:0005737|GO:0003012|GO:0009611|GO:0006928|GO:0009887|GO:0009615|GO:0048729|GO:0030027|GO:0005516|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0000422|GO:0070062|GO:0008092|GO:0016236|GO:0006970|GO:0051607|GO:0000166|GO:0030030|GO:2000145|GO:0019538|GO:0032154|GO:0006996|GO:0005829|GO:0006936|GO:1903008|GO:0046872|GO:0098792|GO:0035639|GO:0000423|GO:0001944|GO:0043412|GO:0072358|GO:0007005|GO:0001883|GO:0003779|GO:0030334|GO:0036211|GO:0032432|GO:0060840|GO:0060537|GO:0042060|GO:0048844|GO:0006811|GO:0032549|GO:0030031|GO:0071470|GO:0016301|GO:0043269|GO:0042641|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0060415|GO:0030335|GO:0007517|GO:0051928|GO:0072359|GO:0016773|GO:0005856|GO:0090303|GO:0048644|GO:0050691|GO:0006971|GO:0015629|GO:0006939|GO:0005524|GO:0006812|GO:0030554|GO:0016310|GO:0002230|GO:0032060|GO:0071476|GO:0001725|GO:0035909|GO:0035904|GO:0004672|GO:0048745|GO:0060414|GO:0007264|GO:0006464|GO:0098779|GO:0061041|GO:0014820|GO:0006468|GO:0004674|GO:0030001|GO:0051924|GO:0004687|GO:0006816 locomotion|developmental process|immune system process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of transport|response to stress|organic substance metabolic process|catabolic process|ion binding|response to abiotic stimulus|cell surface|cellular metabolic process|autophagy|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|cell leading edge|intracellular|regulation of immune system process|protein binding|transferase activity|anatomical structure development|blood vessel morphogenesis|positive regulation of cellular component movement|tissue development|transport|blood vessel development|multicellular organism development|regulation of defense response to virus|animal organ development|anion binding|defense response|nucleoside binding|positive regulation of ion transport|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cell motility|cellular response to stress|cellular component assembly|defense response to other organism|muscle structure development|cation binding|cytoplasm|muscle system process|response to wounding|movement of cell or subcellular component|organ morphogenesis|response to virus|tissue morphogenesis|lamellipodium|calmodulin binding|cell communication|regulation of cellular component movement|cell migration|signal transduction|mitophagy|extracellular exosome|cytoskeletal protein binding|macroautophagy|response to osmotic stress|defense response to virus|nucleotide binding|cell projection organization|regulation of cell motility|protein metabolic process|cleavage furrow|organelle organization|cytosol|muscle contraction|organelle disassembly|metal ion binding|xenophagy|purine ribonucleoside triphosphate binding|macromitophagy|vasculature development|macromolecule modification|cardiovascular system development|mitochondrion organization|purine nucleoside binding|actin binding|regulation of cell migration|protein modification process|actin filament bundle|artery development|muscle tissue development|wound healing|artery morphogenesis|ion transport|ribonucleoside binding|cell projection assembly|cellular response to osmotic stress|kinase activity|regulation of ion transport|actomyosin|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|muscle tissue morphogenesis|positive regulation of cell migration|muscle organ development|positive regulation of calcium ion transport|circulatory system development|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|positive regulation of wound healing|muscle organ morphogenesis|regulation of defense response to virus by host|hypotonic response|actin cytoskeleton|smooth muscle contraction|ATP binding|cation transport|adenyl nucleotide binding|phosphorylation|positive regulation of defense response to virus by host|bleb assembly|cellular hypotonic response|stress fiber|aorta morphogenesis|aorta development|protein kinase activity|smooth muscle tissue development|aorta smooth muscle tissue morphogenesis|small GTPase mediated signal transduction|cellular protein modification process|mitophagy in response to mitochondrial depolarization|regulation of wound healing|tonic smooth muscle contraction|protein phosphorylation|protein serine/threonine kinase activity|metal ion transport|regulation of calcium ion transport|myosin light chain kinase activity|calcium ion transport K00907 myosin-light-chain kinase[2.7.11.18] hsa04810|hsa04510|hsa04020|hsa04022|hsa04921|hsa04611|hsa04270|hsa04971 Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human) 3:123610049-123884331 27 13 31 47 76 68 0.0541341115904822 0.0236888226435127 0.0560382709594754 0.0844308238202762 0.125021606300728 0.127774009231259 0.0446204017311568 0.112408813117421 -1.33297974292543 0.000820878647308676 0.00499928827759144 DOWN ENSG00000273669 RP11-405M12.4 - - - - - - - 18:75073543-75074205 11 9 12 6 2 0 1.17360833017234 0.872724198144035 1.15435388229346 0.573582376532441 0.175065360210817 0 1.06689547020328 0.249549245581086 2.09602238656629 0.000821765452248598 0.00500366832784614 UP ENSG00000256664 RP11-611O2.3 - - - - - - - 12:68841946-68842384 63 2 1 1 1 1 10.1513584944318 0.292880647285055 0.145204277493951 0.144302490890232 0.132262477413104 0.150992586281818 3.52981447307027 0.142519184861718 4.63036431525864 0.000831831794116028 0.00505671072725309 UP ENSG00000088854 C20orf194 chromosome 20 open reading frame 194 [Source:HGNC Symbol;Acc:HGNC:17721] - - - - - - 20:3249305-3407625 86 81 169 224 208 344 0.70076620865543 0.599850465736954 1.24158396726791 1.6353947882095 1.39061403250102 2.62702310755691 0.847400213886765 1.88434397608914 -1.15294694666652 0.000832572976932636 0.00506018600434587 DOWN ENSG00000250284 CTB-1I21.1 - - - - - - - 5:136734927-136754686 1 1 0 4 9 7 0.125472860678393 0.114038522583226 0 0.449509592956275 0.926128657559289 0.822820451053951 0.079837127753873 0.732819567189838 -3.19832630183144 0.000835393799379183 0.00507526383530039 DOWN ENSG00000269887 RP11-477H21.2 - - - - - - - 1:164680085-164680799 1 1 4 7 9 18 0.0989743963952641 0.089954862569146 0.356800290890705 0.620467005792756 0.730540647361453 1.6689293011185 0.181909849951705 1.00664565142424 -2.46826036226167 0.000840114710151894 0.00510186829879468 DOWN ENSG00000134533 RERG RAS-like, estrogen-regulated, growth inhibitor [Source:HGNC Symbol;Acc:HGNC:15980] GO:0040007|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0016049|GO:0043167|GO:0045926|GO:0016043|GO:0043227|GO:0040008|GO:0016787|GO:0005622|GO:0005515|GO:0042127|GO:0006810|GO:0005102|GO:0043168|GO:0001882|GO:0051128|GO:0016817|GO:0043231|GO:0030308|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0009725|GO:0008285|GO:0000166|GO:0010033|GO:0001558|GO:0005829|GO:0035639|GO:0051427|GO:0001883|GO:0015031|GO:0016818|GO:0032549|GO:0035556|GO:0017076|GO:0019003|GO:0005634|GO:0032561|GO:0035257|GO:0005525|GO:0007264|GO:0019001|GO:0016462|GO:0035258|GO:0017111|GO:0003924|GO:0030331 growth|signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|cell growth|ion binding|negative regulation of growth|cellular component organization|membrane-bounded organelle|regulation of growth|hydrolase activity|intracellular|protein binding|regulation of cell proliferation|transport|receptor binding|anion binding|nucleoside binding|regulation of cellular component organization|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|negative regulation of cell growth|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|response to hormone|negative regulation of cell proliferation|nucleotide binding|response to organic substance|regulation of cell growth|cytosol|purine ribonucleoside triphosphate binding|hormone receptor binding|purine nucleoside binding|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|GDP binding|nucleus|guanyl ribonucleotide binding|nuclear hormone receptor binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding|pyrophosphatase activity|steroid hormone receptor binding|nucleoside-triphosphatase activity|GTPase activity|estrogen receptor binding - - - - 12:15107783-15348675 18 20 35 50 52 102 0.131237929706851 0.132523813809667 0.230076112730169 0.326624860226515 0.31107082711913 0.696968896055665 0.164612618748896 0.444888194467103 -1.43436788271412 0.0008428950866534 0.00511667139425592 DOWN ENSG00000262560 RP11-296A16.1 - GO:0005215|GO:0016020|GO:0022857|GO:0031224|GO:0006810|GO:0022891|GO:0016021|GO:0006811|GO:0015075|GO:0006820|GO:0015711|GO:0008509|GO:0006812|GO:0046942|GO:0046943|GO:0006865|GO:0008324|GO:0015804|GO:0015171|GO:0015807|GO:0008514|GO:0015175|GO:0015179|GO:0015194|GO:0015825 transporter activity|membrane|transmembrane transporter activity|intrinsic component of membrane|transport|substrate-specific transmembrane transporter activity|integral component of membrane|ion transport|ion transmembrane transporter activity|anion transport|organic anion transport|anion transmembrane transporter activity|cation transport|carboxylic acid transport|carboxylic acid transmembrane transporter activity|amino acid transport|cation transmembrane transporter activity|neutral amino acid transport|amino acid transmembrane transporter activity|L-amino acid transport|organic anion transmembrane transporter activity|neutral amino acid transmembrane transporter activity|L-amino acid transmembrane transporter activity|L-serine transmembrane transporter activity|L-serine transport - - - - 15:43772617-43799133 11 8 15 5 2 2 0.334523784567612 0.221108519618468 0.411280054073015 0.13623052619439 0.0499004014702372 0.0569954818381067 0.322304119419698 0.0810421365009113 1.99167851453561 0.000843758960185499 0.00511983333280039 UP ENSG00000220563 PKMP3 pyruvate kinase, muscle pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:44245] - - - - - - 6:85659892-85660606 9 11 3 2 0 1 0.890398876934174 0.989077968570118 0.267553540997583 0.177289098200936 0 0.0927073361926127 0.715676795500625 0.0899988114645162 2.99133034941779 0.000850594760919265 0.00515921495174395 UP ENSG00000162591 MEGF6 multiple EGF-like-domains 6 [Source:HGNC Symbol;Acc:HGNC:3232] GO:0005576|GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872|GO:0005509 extracellular region|binding|ion binding|protein binding|cation binding|metal ion binding|calcium ion binding - - - - 1:3489920-3611495 70 89 180 205 217 482 0.552936704546985 0.638928007782809 1.28194107939626 1.45088308386631 1.40639385583526 3.56825781427504 0.824601930575351 2.1418449179922 -1.37708428036187 0.000852239315697727 0.00516709027839966 DOWN ENSG00000132394 EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific [Source:HGNC Symbol;Acc:HGNC:24614] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003676|GO:0043021|GO:0034641|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0005737|GO:0030529|GO:0000166|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0035639|GO:0001883|GO:0016818|GO:0032549|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0017076|GO:0051246|GO:0009059|GO:0005634|GO:0032561|GO:0043043|GO:0000049|GO:0010608|GO:0006412|GO:0006417|GO:0044822|GO:0005525|GO:0008135|GO:0019001|GO:0016462|GO:0006414|GO:0003746|GO:0003729|GO:0017111|GO:0003924|GO:0001514|GO:0035368 macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|protein binding|regulation of metabolic process|nucleic acid binding|ribonucleoprotein complex binding|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|intracellular ribonucleoprotein complex|nucleotide binding|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|purine nucleotide binding|regulation of protein metabolic process|macromolecule biosynthetic process|nucleus|guanyl ribonucleotide binding|peptide biosynthetic process|tRNA binding|posttranscriptional regulation of gene expression|translation|regulation of translation|poly(A) RNA binding|GTP binding|translation factor activity, RNA binding|guanyl nucleotide binding|pyrophosphatase activity|translational elongation|translation elongation factor activity|mRNA binding|nucleoside-triphosphatase activity|GTPase activity|selenocysteine incorporation|selenocysteine insertion sequence binding - - - - 3:128153454-128408646 109 115 239 277 386 329 1.79059981341591 1.71692293631 3.53984842342521 4.07707548747766 5.20268409280936 5.06520213249766 2.34912372438371 4.78165390426156 -1.0253870120081 0.000853122461188368 0.00517139450889696 DOWN ENSG00000180035 ZNF48 zinc finger protein 48 [Source:HGNC Symbol;Acc:HGNC:13114] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 16:30378106-30400108 670 582 276 234 357 178 5.99010032691914 4.72892702974396 2.22475671291921 1.87444471237398 2.61875904447398 1.49144887879073 4.31459468986077 1.99488421187956 1.11292002875023 0.000854168200546293 0.00517668239121174 UP ENSG00000100605 ITPK1 inositol-tetrakisphosphate 1-kinase [Source:HGNC Symbol;Acc:HGNC:6177] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0045177|GO:0071944|GO:0016853|GO:0016787|GO:0005622|GO:0005886|GO:0016740|GO:0048856|GO:0050817|GO:0009888|GO:0035295|GO:0016324|GO:0007275|GO:0043647|GO:0043168|GO:0016788|GO:0044281|GO:0001882|GO:0016772|GO:0019637|GO:0043169|GO:0005737|GO:0009611|GO:0021915|GO:0007154|GO:0007165|GO:0000166|GO:0050878|GO:0005829|GO:0046872|GO:0035639|GO:0007596|GO:0006066|GO:0001883|GO:0009790|GO:0032957|GO:0042060|GO:0032549|GO:0007599|GO:0016301|GO:0060429|GO:0006796|GO:0007399|GO:0017076|GO:0016773|GO:0042578|GO:0016311|GO:0009792|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0016791|GO:0052725|GO:0047325|GO:0043009|GO:0052835|GO:0052726|GO:0052745|GO:0052825|GO:0052831|GO:0052830 developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|apical part of cell|cell periphery|isomerase activity|hydrolase activity|intracellular|plasma membrane|transferase activity|anatomical structure development|coagulation|tissue development|tube development|apical plasma membrane|multicellular organism development|inositol phosphate metabolic process|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|nucleoside binding|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|cation binding|cytoplasm|response to wounding|neural tube development|cell communication|signal transduction|nucleotide binding|regulation of body fluid levels|cytosol|metal ion binding|purine ribonucleoside triphosphate binding|blood coagulation|alcohol metabolic process|purine nucleoside binding|embryo development|inositol trisphosphate metabolic process|wound healing|ribonucleoside binding|hemostasis|kinase activity|epithelium development|phosphate-containing compound metabolic process|nervous system development|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|phosphoric ester hydrolase activity|dephosphorylation|embryo development ending in birth or egg hatching|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|phosphatase activity|inositol-1,3,4-trisphosphate 6-kinase activity|inositol tetrakisphosphate 1-kinase activity|chordate embryonic development|inositol-3,4,6-trisphosphate 1-kinase activity|inositol-1,3,4-trisphosphate 5-kinase activity|inositol phosphate phosphatase activity|inositol-1,3,4,5,6-pentakisphosphate 1-phosphatase activity|inositol-1,3,4,6-tetrakisphosphate 1-phosphatase activity|inositol-1,3,4,6-tetrakisphosphate 6-phosphatase activity - - - - 14:92936914-93116320 330 409 271 913 1065 404 1.65706935103832 1.86651075282156 1.22690553182438 4.10767110275947 4.38778020005502 1.90124412129037 1.58349521189475 3.46556514136829 -1.12997813166891 0.000855065605929028 0.00518034647310946 DOWN ENSG00000164683 HEY1 hes-related family bHLH transcription factor with YRPW motif 1 [Source:HGNC Symbol;Acc:HGNC:4880] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0044237|GO:0003006|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0003179|GO:0060674|GO:0001890|GO:0045595|GO:0003188|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0001568|GO:0007275|GO:0060411|GO:0003676|GO:0048513|GO:0034641|GO:0031325|GO:0046483|GO:0051098|GO:0061061|GO:0043231|GO:0048608|GO:0005737|GO:0000981|GO:0003170|GO:0009887|GO:0009966|GO:0048729|GO:0046983|GO:0048568|GO:0009890|GO:0036304|GO:0010646|GO:0006139|GO:0001892|GO:0001525|GO:0007154|GO:0044092|GO:0061383|GO:0007165|GO:0009968|GO:0003279|GO:0008134|GO:0009725|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0060711|GO:0003272|GO:0003205|GO:0000902|GO:0003677|GO:0010468|GO:0034645|GO:0051101|GO:0007166|GO:0051100|GO:0033993|GO:0003208|GO:0001944|GO:0061458|GO:0072358|GO:0060347|GO:0010629|GO:0061314|GO:0042692|GO:0051252|GO:0003007|GO:0000904|GO:0009790|GO:0000983|GO:0010628|GO:0003181|GO:0060840|GO:0060412|GO:0048844|GO:0060485|GO:0031981|GO:0003231|GO:0001570|GO:0008593|GO:0005654|GO:0003171|GO:0003198|GO:0003197|GO:0014070|GO:0060429|GO:1901342|GO:0048864|GO:0010467|GO:2001212|GO:0071310|GO:0003190|GO:0031328|GO:0009059|GO:0030154|GO:0003281|GO:0060837|GO:0016070|GO:0060716|GO:0072359|GO:0032870|GO:0003184|GO:0010557|GO:0005634|GO:0061384|GO:0048545|GO:0045746|GO:0003158|GO:0045893|GO:0048863|GO:0060317|GO:0009792|GO:2000677|GO:0030855|GO:0051145|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0014031|GO:1902679|GO:0071383|GO:0071407|GO:0003690|GO:0035909|GO:0035904|GO:0048762|GO:0007219|GO:0001837|GO:0071396|GO:0031960|GO:0006351|GO:0003203|GO:0060842|GO:0006355|GO:0043392|GO:0051384|GO:0045944|GO:0045446|GO:0006366|GO:0035912|GO:1903507|GO:0006357|GO:1903506|GO:0035907|GO:0043009|GO:0071384|GO:0000122|GO:2000820|GO:2000678|GO:0071385|GO:0003696|GO:0001701|GO:0035939 developmental process|reproduction|signaling|cell|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|heart valve morphogenesis|placenta blood vessel development|placenta development|regulation of cell differentiation|heart valve formation|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|cardiac septum morphogenesis|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of binding|muscle structure development|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|heart valve development|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|protein dimerization activity|embryonic organ development|negative regulation of biosynthetic process|umbilical cord morphogenesis|regulation of cell communication|nucleobase-containing compound metabolic process|embryonic placenta development|angiogenesis|cell communication|negative regulation of molecular function|trabecula morphogenesis|signal transduction|negative regulation of signal transduction|cardiac septum development|transcription factor binding|response to hormone|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|labyrinthine layer development|endocardial cushion formation|cardiac chamber development|cell morphogenesis|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of DNA binding|cell surface receptor signaling pathway|negative regulation of binding|response to lipid|cardiac ventricle morphogenesis|vasculature development|reproductive system development|cardiovascular system development|heart trabecula formation|negative regulation of gene expression|Notch signaling involved in heart development|muscle cell differentiation|regulation of RNA metabolic process|heart morphogenesis|cell morphogenesis involved in differentiation|embryo development|transcription factor activity, RNA polymerase II core promoter sequence-specific|positive regulation of gene expression|atrioventricular valve morphogenesis|artery development|ventricular septum morphogenesis|artery morphogenesis|mesenchyme development|nuclear lumen|cardiac ventricle development|vasculogenesis|regulation of Notch signaling pathway|nucleoplasm|atrioventricular valve development|epithelial to mesenchymal transition involved in endocardial cushion formation|endocardial cushion development|response to organic cyclic compound|epithelium development|regulation of vasculature development|stem cell development|gene expression|regulation of vasculogenesis|cellular response to organic substance|atrioventricular valve formation|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|ventricular septum development|blood vessel endothelial cell differentiation|RNA metabolic process|labyrinthine layer blood vessel development|circulatory system development|cellular response to hormone stimulus|pulmonary valve morphogenesis|positive regulation of macromolecule biosynthetic process|nucleus|heart trabecula morphogenesis|response to steroid hormone|negative regulation of Notch signaling pathway|endothelium development|positive regulation of transcription, DNA-templated|stem cell differentiation|cardiac epithelial to mesenchymal transition|embryo development ending in birth or egg hatching|regulation of transcription regulatory region DNA binding|epithelial cell differentiation|smooth muscle cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|mesenchymal cell development|negative regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|aorta morphogenesis|aorta development|mesenchymal cell differentiation|Notch signaling pathway|epithelial to mesenchymal transition|cellular response to lipid|response to corticosteroid|transcription, DNA-templated|endocardial cushion morphogenesis|arterial endothelial cell differentiation|regulation of transcription, DNA-templated|negative regulation of DNA binding|response to glucocorticoid|positive regulation of transcription from RNA polymerase II promoter|endothelial cell differentiation|transcription from RNA polymerase II promoter|dorsal aorta morphogenesis|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|dorsal aorta development|chordate embryonic development|cellular response to corticosteroid stimulus|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation|negative regulation of transcription regulatory region DNA binding|cellular response to glucocorticoid stimulus|satellite DNA binding|in utero embryonic development|microsatellite binding - - - - 8:79764010-79767863 47 87 180 46 32 48 0.358336183545592 0.602826655048169 1.23731217568371 0.314226232322732 0.20017348392048 0.342976813821177 0.732825004759157 0.28579217668813 1.35850230609106 0.000855119830491171 0.00518034647310946 UP ENSG00000172789 HOXC5 homeobox C5 [Source:HGNC Symbol;Acc:HGNC:5127] GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0031981|GO:0005654|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 cell|cellular process|metabolic process|cell junction|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 12:54032853-54035358 20 17 16 9 5 4 0.783788099674348 0.605492831026067 0.565345613267267 0.31600865061246 0.160775565220995 0.14689361856558 0.651542181322561 0.207892611466345 1.64802009744486 0.000857818560408634 0.00519458728244206 UP ENSG00000196405 EVL Enah/Vasp-like [Source:HGNC Symbol;Acc:HGNC:20234] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0042995|GO:0030055|GO:0048523|GO:0050794|GO:0040012|GO:0043229|GO:0044089|GO:0048870|GO:0009653|GO:0016043|GO:0009605|GO:0031252|GO:0005622|GO:0005515|GO:0048856|GO:0006935|GO:0048468|GO:0051130|GO:0007275|GO:0010632|GO:0048513|GO:0032535|GO:0005924|GO:0005912|GO:0051128|GO:0022607|GO:0005737|GO:0032970|GO:0006928|GO:0009887|GO:0030027|GO:0019904|GO:0032231|GO:0007154|GO:0051270|GO:0060491|GO:0016477|GO:0007165|GO:0032233|GO:0008092|GO:0005522|GO:0051271|GO:0030030|GO:0048869|GO:0030029|GO:2000145|GO:0010633|GO:0031334|GO:0043254|GO:2000146|GO:0006996|GO:0051017|GO:0000902|GO:0005829|GO:0031175|GO:0031344|GO:1900027|GO:0090132|GO:0007166|GO:0032956|GO:0007010|GO:0017124|GO:0003779|GO:0000904|GO:0030334|GO:0001667|GO:0031345|GO:0030031|GO:0006461|GO:0030036|GO:0030336|GO:0035556|GO:0032273|GO:0033043|GO:0032990|GO:0007399|GO:0097485|GO:0031529|GO:0030154|GO:0030832|GO:0048858|GO:0051496|GO:0005856|GO:0051492|GO:0005925|GO:0010638|GO:0048666|GO:0030182|GO:0007411|GO:0034622|GO:0051259|GO:0030838|GO:0043623|GO:1900028|GO:0008064|GO:0061564|GO:0051493|GO:0010631|GO:0097178|GO:0031032|GO:0022008|GO:0030038|GO:0048667|GO:0007264|GO:0007015|GO:0051495|GO:0048812|GO:0030833|GO:0051258|GO:0007409|GO:0048699|GO:0043149|GO:0051260|GO:0061572|GO:0051262|GO:0008154|GO:0051289|GO:0030041 locomotion|developmental process|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|cell projection|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|intracellular organelle|positive regulation of cellular component biogenesis|cell motility|anatomical structure morphogenesis|cellular component organization|response to external stimulus|cell leading edge|intracellular|protein binding|anatomical structure development|chemotaxis|cell development|positive regulation of cellular component organization|multicellular organism development|regulation of epithelial cell migration|animal organ development|regulation of cellular component size|cell-substrate adherens junction|adherens junction|regulation of cellular component organization|cellular component assembly|cytoplasm|regulation of actin filament-based process|movement of cell or subcellular component|organ morphogenesis|lamellipodium|protein domain specific binding|regulation of actin filament bundle assembly|cell communication|regulation of cellular component movement|regulation of cell projection assembly|cell migration|signal transduction|positive regulation of actin filament bundle assembly|cytoskeletal protein binding|profilin binding|negative regulation of cellular component movement|cell projection organization|cellular developmental process|actin filament-based process|regulation of cell motility|negative regulation of epithelial cell migration|positive regulation of protein complex assembly|regulation of protein complex assembly|negative regulation of cell motility|organelle organization|actin filament bundle assembly|cell morphogenesis|cytosol|neuron projection development|regulation of cell projection organization|regulation of ruffle assembly|epithelium migration|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|cytoskeleton organization|SH3 domain binding|actin binding|cell morphogenesis involved in differentiation|regulation of cell migration|ameboidal-type cell migration|negative regulation of cell projection organization|cell projection assembly|protein complex assembly|actin cytoskeleton organization|negative regulation of cell migration|intracellular signal transduction|positive regulation of protein polymerization|regulation of organelle organization|cell part morphogenesis|nervous system development|neuron projection guidance|ruffle organization|cell differentiation|regulation of actin filament length|cell projection morphogenesis|positive regulation of stress fiber assembly|cytoskeleton|regulation of stress fiber assembly|focal adhesion|positive regulation of organelle organization|neuron development|neuron differentiation|axon guidance|cellular macromolecular complex assembly|protein oligomerization|positive regulation of actin filament polymerization|cellular protein complex assembly|negative regulation of ruffle assembly|regulation of actin polymerization or depolymerization|axon development|regulation of cytoskeleton organization|epithelial cell migration|ruffle assembly|actomyosin structure organization|neurogenesis|contractile actin filament bundle assembly|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|actin filament organization|positive regulation of cytoskeleton organization|neuron projection morphogenesis|regulation of actin filament polymerization|protein polymerization|axonogenesis|generation of neurons|stress fiber assembly|protein homooligomerization|actin filament bundle organization|protein tetramerization|actin polymerization or depolymerization|protein homotetramerization|actin filament polymerization - - - - 14:99971449-100144236 18 28 31 51 59 81 0.0811672336339561 0.114747527138009 0.126033418609119 0.206051335859661 0.218287588050836 0.342312140186089 0.107316059793695 0.255550354698862 -1.25174160294309 0.000857685802219469 0.00519458728244206 DOWN ENSG00000203709 C1orf132 chromosome 1 open reading frame 132 [Source:HGNC Symbol;Acc:HGNC:32018] - - - - - - 1:207801518-207869150 183 240 90 422 310 725 0.712587883878054 0.849331305679659 0.315968908014794 1.47230111995572 0.990411333832005 2.6457794693042 0.625962699190836 1.70283064103064 -1.44378636022681 0.000859440447258953 0.00520229827908937 DOWN ENSG00000254363 CTB-131B5.5 - - - - - - - 5:140157319-140173051 1 1 1 2 9 20 0.0110366022181244 0.0100308369833031 0.00994146566123588 0.0197694487232797 0.0814623460485713 0.206777283383525 0.0103363016208878 0.102669692718459 -3.31221839255693 0.000862534856732311 0.00521891277115655 DOWN ENSG00000086570 FAT2 FAT atypical cadherin 2 [Source:HGNC Symbol;Acc:HGNC:3596] GO:0040011|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0005488|GO:1903561|GO:0043229|GO:0043167|GO:0048870|GO:0005911|GO:0007155|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0005912|GO:0031982|GO:0098609|GO:0043231|GO:0043169|GO:0006928|GO:0016477|GO:0005913|GO:0070062|GO:0016021|GO:0098742|GO:0090132|GO:0046872|GO:0001667|GO:0005634|GO:0005509|GO:0007156|GO:0010631 locomotion|cell|membrane|cellular process|extracellular region|cell junction|binding|extracellular vesicle|intracellular organelle|ion binding|cell motility|cell-cell junction|cell adhesion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|adherens junction|vesicle|cell-cell adhesion|intracellular membrane-bounded organelle|cation binding|movement of cell or subcellular component|cell migration|cell-cell adherens junction|extracellular exosome|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|epithelium migration|metal ion binding|ameboidal-type cell migration|nucleus|calcium ion binding|homophilic cell adhesion via plasma membrane adhesion molecules|epithelial cell migration - - - - 5:151504093-151568944 0 0 0 3 3 6 0 0 0 0.0111117247480555 0.0101777755218963 0.0232500431946175 0 0.0148465144881898 -Inf 0.000864389289594814 0.00522895519911846 DOWN ENSG00000137880 GCHFR GTP cyclohydrolase I feedback regulator [Source:HGNC Symbol;Acc:HGNC:4194] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0009892|GO:0043229|GO:0006807|GO:0043167|GO:0044237|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0030234|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:1903409|GO:0042133|GO:0004857|GO:0034641|GO:0043168|GO:0044281|GO:2001057|GO:0031982|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0030742|GO:0005635|GO:0072593|GO:0043177|GO:0043005|GO:0009890|GO:0036477|GO:0044092|GO:0001505|GO:0031965|GO:0050790|GO:0043086|GO:0044249|GO:0005829|GO:0031410|GO:0044549|GO:0016023|GO:0046209|GO:0030425|GO:0051346|GO:0031988|GO:0006461|GO:0051341|GO:0031406|GO:0006809|GO:0005634|GO:0051259|GO:0043105|GO:0016597|GO:0051291|GO:0042470|GO:0050999 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|negative regulation of metabolic process|intracellular organelle|nitrogen compound metabolic process|ion binding|cellular metabolic process|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|enzyme regulator activity|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|reactive oxygen species biosynthetic process|neurotransmitter metabolic process|enzyme inhibitor activity|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|reactive nitrogen species metabolic process|vesicle|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|GTP-dependent protein binding|nuclear envelope|reactive oxygen species metabolic process|organic acid binding|neuron projection|negative regulation of biosynthetic process|somatodendritic compartment|negative regulation of molecular function|regulation of neurotransmitter levels|nuclear membrane|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|cytosol|cytoplasmic vesicle|GTP cyclohydrolase binding|cytoplasmic, membrane-bounded vesicle|nitric oxide metabolic process|dendrite|negative regulation of hydrolase activity|membrane-bounded vesicle|protein complex assembly|regulation of oxidoreductase activity|carboxylic acid binding|nitric oxide biosynthetic process|nucleus|protein oligomerization|negative regulation of GTP cyclohydrolase I activity|amino acid binding|protein heterooligomerization|melanosome|regulation of nitric-oxide synthase activity - - - - 15:40764020-40767710 1 2 0 5 8 10 0.0187610533994204 0.0340865864682235 0 0.0840064167359891 0.123099537812306 0.175749727075181 0.0176158799558813 0.127618560541159 -2.85688971865377 0.000865736023280247 0.00523403872802926 DOWN ENSG00000101361 NOP56 NOP56 ribonucleoprotein [Source:HGNC Symbol;Acc:HGNC:15911] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0030529|GO:0006139|GO:0022613|GO:0005730|GO:0003723|GO:0030684|GO:0043412|GO:0042254|GO:0005732|GO:0031981|GO:0005654|GO:0010467|GO:1990226|GO:0016070|GO:0005634|GO:0070761|GO:0006364|GO:0006396|GO:0030515|GO:0034660|GO:0032040|GO:0009451|GO:0031428|GO:0044822|GO:0016072|GO:0000154 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|nucleolus|RNA binding|preribosome|macromolecule modification|ribosome biogenesis|small nucleolar ribonucleoprotein complex|nuclear lumen|nucleoplasm|gene expression|histone methyltransferase binding|RNA metabolic process|nucleus|pre-snoRNP complex|rRNA processing|RNA processing|snoRNA binding|ncRNA metabolic process|small-subunit processome|RNA modification|box C/D snoRNP complex|poly(A) RNA binding|rRNA metabolic process|rRNA modification K14564 nucleolar protein 56[-] hsa03008 Ribosome biogenesis in eukaryotes - Homo sapiens (human) 20:2652145-2658393 8966 9171 4464 4478 5053 2072 44.3856541056412 41.2610825098742 19.9242644723958 19.862125016433 20.5239584690606 9.61308286279518 35.1903336959704 16.6663887827629 1.07823765479515 0.000866891193451332 0.00523890074682106 UP ENSG00000261534 RP11-244O19.1 - - - - - - - 9:121815674-121819452 6 3 14 17 35 30 0.112305207115372 0.0510432206655407 0.23627751467425 0.285113108020685 0.537534042132399 0.526291195642538 0.133208647485054 0.449646115265207 -1.75510226387836 0.000877731257659841 0.00529904731368592 DOWN ENSG00000164707 SLC13A4 solute carrier family 13 (sodium/sulfate symporter), member 4 [Source:HGNC Symbol;Acc:HGNC:15827] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0006811|GO:0015075|GO:0015116|GO:0034220|GO:0098655|GO:0006820|GO:0015293|GO:0008509|GO:0006812|GO:0008272|GO:0008271|GO:0008324|GO:0015382|GO:0022890|GO:0030001|GO:0015698|GO:0015672|GO:0035725|GO:0006814|GO:0015077|GO:0046873|GO:0015081 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|plasma membrane|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|ion transport|ion transmembrane transporter activity|sulfate transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|anion transport|symporter activity|anion transmembrane transporter activity|cation transport|sulfate transport|secondary active sulfate transmembrane transporter activity|cation transmembrane transporter activity|sodium:sulfate symporter activity|inorganic cation transmembrane transporter activity|metal ion transport|inorganic anion transport|monovalent inorganic cation transport|sodium ion transmembrane transport|sodium ion transport|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|sodium ion transmembrane transporter activity - - - - 7:135681237-135729258 11 10 29 46 39 57 0.0658683080423486 0.0544208093448485 0.156567352385323 0.246795139548828 0.19160905890611 0.319883272985926 0.0922854899241734 0.252762490480288 -1.45360665049969 0.000883230344259327 0.00532793669378015 DOWN ENSG00000087301 TXNDC16 thioredoxin domain containing 16 [Source:HGNC Symbol;Acc:HGNC:19965] GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0050794|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031982|GO:0043231|GO:0005737|GO:0042592|GO:0019725|GO:0005783|GO:0070062|GO:0045454|GO:0005788 cell|cellular process|extracellular region|binding|extracellular vesicle|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|vesicle|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|cellular homeostasis|endoplasmic reticulum|extracellular exosome|cell redox homeostasis|endoplasmic reticulum lumen - - - - 14:52430590-52552522 79 88 164 207 240 254 1.0270507969539 1.03975052066865 1.92231823819998 2.41121479897748 2.56004192635627 3.09477942077788 1.32970651860751 2.68867871537054 -1.01578950853494 0.000885426682643967 0.00534010670376828 DOWN ENSG00000228809 RP4-705D16.3 - - - - - - - 20:16714844-16730948 5 4 5 0 0 1 0.204925228977563 0.148985636336198 0.184737477292409 0 0 0.0384042557228958 0.17954944753539 0.0128014185742986 3.81000561914122 0.000886146838895316 0.00534337057733402 UP ENSG00000250159 RP11-381K20.2 - - - - - - - 5:137814333-137889336 10 17 14 51 41 26 0.383172063641198 0.592044723728088 0.483690535186343 1.75098987303928 1.2890282484711 0.933716646842836 0.486302440851876 1.32457825611774 -1.44560734279563 0.000893213155768262 0.00538271811713882 DOWN ENSG00000125864 BFSP1 beaded filament structural protein 1 [Source:HGNC Symbol;Acc:HGNC:1040] GO:0032502|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0005200|GO:0043229|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0005212|GO:0048856|GO:0009888|GO:0048468|GO:0005938|GO:0002088|GO:0007275|GO:0048513|GO:0005882|GO:0043231|GO:0005737|GO:0007423|GO:0048869|GO:0001654|GO:0002064|GO:0005739|GO:0070306|GO:0060429|GO:0030154|GO:0048469|GO:0005856|GO:0015629|GO:0070307|GO:0030855|GO:0043010|GO:0045111 developmental process|structural molecule activity|cell|membrane|cellular process|binding|structural constituent of cytoskeleton|intracellular organelle|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|structural constituent of eye lens|anatomical structure development|tissue development|cell development|cell cortex|lens development in camera-type eye|multicellular organism development|animal organ development|intermediate filament|intracellular membrane-bounded organelle|cytoplasm|sensory organ development|cellular developmental process|eye development|epithelial cell development|mitochondrion|lens fiber cell differentiation|epithelium development|cell differentiation|cell maturation|cytoskeleton|actin cytoskeleton|lens fiber cell development|epithelial cell differentiation|camera-type eye development|intermediate filament cytoskeleton - - - - 20:17493905-17569220 62 66 68 129 119 183 0.985989137957043 0.953903313223603 0.974994163459767 1.83809385214197 1.55273378906078 2.72748263773185 0.971628871546804 2.03943675964487 -1.06969350687007 0.000897060897221592 0.00540372397612054 DOWN ENSG00000279347 RP11-85I17.2 - - - - - - - 8:119838736-119840385 17 17 21 7 9 4 0.72879012157167 0.662372460607304 0.811700435002494 0.268869035843527 0.31656761385663 0.160692716067195 0.734287672393823 0.248709788589117 1.5618820899506 0.000898031793237596 0.00540848116911745 UP ENSG00000235836 AC124944.4 - - - - - - - 3:195843986-195844596 0 0 1 3 6 8 0 0 0.104328441603673 0.311146479074438 0.569893619409681 0.868013878514151 0.0347761472012243 0.583017992332757 -4.06737039414059 0.0008985244878067 0.00541035701068601 DOWN ENSG00000145700 ANKRD31 ankyrin repeat domain 31 [Source:HGNC Symbol;Acc:HGNC:26853] GO:0005488|GO:0005515 binding|protein binding - - - - 5:75068275-75236878 3 4 9 16 23 19 0.0312844662911179 0.0379052488673759 0.0846062933068326 0.149473691553259 0.196767839173168 0.185667776485473 0.0512653361551088 0.177303102403967 -1.79016222019045 0.000899005829962018 0.00541216375230613 DOWN ENSG00000124635 HIST1H2BJ histone cluster 1, H2bj [Source:HGNC Symbol;Acc:HGNC:4761] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0097159|GO:0043229|GO:0006950|GO:0006955|GO:0000785|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005615|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0045087|GO:0006959|GO:0003676|GO:0006952|GO:0022607|GO:0098542|GO:0043231|GO:0005737|GO:0046983|GO:0009617|GO:0000790|GO:0019730|GO:0000786|GO:0006996|GO:0051276|GO:0003677|GO:0002385|GO:0046982|GO:0006325|GO:0000788|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0002227|GO:0042742|GO:0005634|GO:0019731|GO:0006334|GO:0034622|GO:0034728|GO:0006333|GO:0050830|GO:0065004|GO:0031497|GO:0071103|GO:0006323 macromolecular complex|immune system process|cell|cellular process|extracellular region|response to stimulus|binding|organic cyclic compound binding|intracellular organelle|response to stress|immune response|chromatin|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|extracellular space|protein-DNA complex|intracellular|protein binding|protein complex|innate immune response|humoral immune response|nucleic acid binding|defense response|cellular component assembly|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|response to bacterium|nuclear chromatin|antimicrobial humoral response|nucleosome|organelle organization|chromosome organization|DNA binding|mucosal immune response|protein heterodimerization activity|chromatin organization|nuclear nucleosome|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|innate immune response in mucosa|defense response to bacterium|nucleus|antibacterial humoral response|nucleosome assembly|cellular macromolecular complex assembly|nucleosome organization|chromatin assembly or disassembly|defense response to Gram-positive bacterium|protein-DNA complex assembly|chromatin assembly|DNA conformation change|DNA packaging K11252 histone H2B[-] hsa05203|hsa05034|hsa05322 Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 6:27125897-27132750 14 8 12 38 48 21 0.569485993227837 0.295743770346496 0.440101566394803 1.3849386318848 1.60196341329576 0.800541510312181 0.435110443323045 1.26248118516425 -1.53680833813346 0.000899912226685254 0.00541652814827854 DOWN ENSG00000260618 RP11-23N2.4 - - - - - - - 15:52577842-52598709 2 3 6 15 11 18 0.113445971047578 0.154685108977609 0.306871140320995 0.762374282274658 0.511952603595197 0.956924178267626 0.191667406782061 0.743750354712494 -1.95621342511313 0.000903029745875221 0.00543310157866966 DOWN ENSG00000251503 APITD1-CORT APITD1-CORT readthrough [Source:HGNC Symbol;Acc:HGNC:38843] GO:0005576|GO:0005488|GO:0005515|GO:0005102|GO:0046983|GO:0046982|GO:0005179 extracellular region|binding|protein binding|receptor binding|protein dimerization activity|protein heterodimerization activity|hormone activity - - - - 1:10430102-10452153 0 17 6 46 23 45 0 0.299264665937035 0.104783217957361 0.798299831185735 0.365518351848514 0.816870516360713 0.134682627964799 0.660229566464987 -2.29340397009877 0.000903569274224522 0.00543525228948194 DOWN ENSG00000260971 RP11-504A18.1 - - - - - - - 1:56248294-56258571 0 0 0 5 2 5 0 0 0 0.234546412974205 0.0859129043817703 0.245373237334561 0 0.188610851563512 -Inf 0.000906197376824215 0.00544667132830886 DOWN ENSG00000239482 RP11-90K6.1 - - - - - - - 3:112302478-112332791 4 3 4 14 13 18 0.210203753189198 0.143307823844783 0.189533586914453 0.65923620839204 0.560529888932379 0.886541196359383 0.181015054649478 0.702102431227934 -1.9555718354803 0.000906976922198084 0.0054502594676533 DOWN ENSG00000067606 PRKCZ protein kinase C, zeta [Source:HGNC Symbol;Acc:HGNC:9412] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0043209|GO:0016049|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0045177|GO:0048870|GO:0023051|GO:0005911|GO:0044297|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0023057|GO:0009893|GO:0031252|GO:0009058|GO:0002684|GO:0050793|GO:0048589|GO:0016247|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0035748|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0048856|GO:0019222|GO:0060341|GO:0008284|GO:0042127|GO:0002250|GO:1903706|GO:0050817|GO:0016337|GO:0002286|GO:0050804|GO:0042391|GO:0045595|GO:0006725|GO:0051640|GO:0048468|GO:0043025|GO:0050867|GO:0006810|GO:1901360|GO:0005884|GO:0010941|GO:0045179|GO:0016324|GO:0005938|GO:0007275|GO:0048513|GO:0050877|GO:0070489|GO:0034641|GO:0043168|GO:0032940|GO:0006952|GO:0030155|GO:0001882|GO:0016772|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0042092|GO:0050806|GO:0022607|GO:1900076|GO:0001817|GO:0098609|GO:0050803|GO:0045597|GO:0043231|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0001816|GO:0007267|GO:0009611|GO:0032880|GO:0071889|GO:0051222|GO:0071559|GO:0005635|GO:0006928|GO:0051656|GO:0002696|GO:0001775|GO:0043005|GO:0031589|GO:0015459|GO:0009966|GO:0002263|GO:0002367|GO:0045184|GO:0036477|GO:0010828|GO:0001819|GO:0019904|GO:0060548|GO:0010646|GO:0006139|GO:0043085|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0007163|GO:0007154|GO:0044092|GO:0061024|GO:0010970|GO:1900078|GO:0016477|GO:0007165|GO:0002366|GO:0050778|GO:0048588|GO:0009968|GO:0070062|GO:0043560|GO:0051649|GO:0045785|GO:0009725|GO:0008219|GO:0031941|GO:0007611|GO:0051047|GO:0050790|GO:0000166|GO:0030030|GO:0043086|GO:0048869|GO:0030029|GO:0009967|GO:0044249|GO:0007017|GO:0019538|GO:0043254|GO:0023014|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0043296|GO:0002292|GO:0010256|GO:0050878|GO:0005768|GO:0002443|GO:0006996|GO:0051090|GO:0060560|GO:0000165|GO:0002369|GO:0032616|GO:1902533|GO:0051650|GO:0051249|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0031333|GO:0046326|GO:2000463|GO:0010468|GO:0034645|GO:0030168|GO:0032736|GO:0048167|GO:0046872|GO:0007166|GO:0051899|GO:0035639|GO:0030424|GO:0043412|GO:0007010|GO:0030097|GO:0046628|GO:0032613|GO:0030098|GO:0051345|GO:0060081|GO:0043069|GO:0007596|GO:0051252|GO:0043274|GO:0045064|GO:0005815|GO:0060078|GO:0001883|GO:0034109|GO:0035745|GO:0051223|GO:0032633|GO:0015031|GO:1901652|GO:0045622|GO:0071417|GO:0032753|GO:0010628|GO:0007009|GO:0051347|GO:0002718|GO:0032673|GO:0036211|GO:0032269|GO:0007613|GO:0071560|GO:0070201|GO:0007160|GO:0042060|GO:0046907|GO:0006954|GO:0032549|GO:0050714|GO:0002828|GO:0051251|GO:0051091|GO:0050715|GO:0002720|GO:0022407|GO:0051046|GO:0072657|GO:0031981|GO:0030010|GO:0032634|GO:0043434|GO:0007599|GO:0032733|GO:0007018|GO:0007159|GO:0009306|GO:0010810|GO:0051247|GO:0048471|GO:0051346|GO:0070848|GO:0016363|GO:0006461|GO:0016301|GO:0032674|GO:0002821|GO:0030036|GO:0034613|GO:0002460|GO:0050663|GO:0019900|GO:0032270|GO:0042110|GO:0012501|GO:0060291|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0002830|GO:0045624|GO:0010467|GO:0032990|GO:0007399|GO:0046903|GO:0071310|GO:0050890|GO:0017076|GO:0098815|GO:0002819|GO:0051648|GO:0032754|GO:0031328|GO:0046627|GO:0051246|GO:0009059|GO:0010811|GO:0030154|GO:0034399|GO:0022409|GO:0048858|GO:0045121|GO:0046626|GO:0005923|GO:0042093|GO:0050707|GO:1902531|GO:0016070|GO:0008643|GO:0000226|GO:0072384|GO:0043203|GO:0016773|GO:0032870|GO:0005856|GO:0010557|GO:0005634|GO:0043067|GO:1990138|GO:0010827|GO:0048666|GO:0030182|GO:0002521|GO:0015629|GO:0045893|GO:0002456|GO:0031401|GO:0050863|GO:0031532|GO:2000667|GO:2001181|GO:0051259|GO:1901653|GO:0043408|GO:0072659|GO:0047496|GO:0032774|GO:0005524|GO:0002726|GO:2001141|GO:0030217|GO:0050708|GO:0071363|GO:0030554|GO:0046324|GO:0016310|GO:0045619|GO:0051092|GO:0034112|GO:0070371|GO:0007179|GO:0070486|GO:0046631|GO:0035743|GO:0045630|GO:0007167|GO:0001952|GO:2000664|GO:0015630|GO:2000553|GO:0070528|GO:0071375|GO:0001954|GO:0043410|GO:0042981|GO:2001179|GO:0043066|GO:0004672|GO:0002724|GO:0007616|GO:0032868|GO:0060079|GO:0019901|GO:0022008|GO:0006464|GO:0050870|GO:0030705|GO:0048812|GO:0045621|GO:1990778|GO:0060193|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:1903039|GO:0033674|GO:0072608|GO:0045582|GO:0045859|GO:0008645|GO:0045860|GO:0002711|GO:0010517|GO:0006468|GO:0046632|GO:0048699|GO:0051291|GO:0045580|GO:1903506|GO:0042325|GO:0070374|GO:0001932|GO:0032869|GO:0018193|GO:0042326|GO:0004674|GO:0001934|GO:0007178|GO:0010518|GO:0035710|GO:0001933|GO:0070372|GO:0071593|GO:0042327|GO:0007268|GO:0007169|GO:0048010|GO:0050730|GO:0031584|GO:0046638|GO:0015758|GO:0018105|GO:0043367|GO:0050732|GO:0004697|GO:2000516|GO:0032147|GO:0008286|GO:0018108|GO:0046323|GO:0032148|GO:0043372|GO:0043370 locomotion|developmental process|growth|macromolecular complex|immune system process|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|myelin sheath|cell growth|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|apical part of cell|cell motility|regulation of signaling|cell-cell junction|cell body|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|negative regulation of signaling|positive regulation of metabolic process|cell leading edge|biosynthetic process|positive regulation of immune system process|regulation of developmental process|developmental growth|channel regulator activity|intracellular|regulation of immune system process|immune system development|protein binding|myelin sheath abaxonal region|plasma membrane|protein complex|endomembrane system|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|adaptive immune response|regulation of hemopoiesis|coagulation|single organismal cell-cell adhesion|T cell activation involved in immune response|modulation of synaptic transmission|regulation of membrane potential|regulation of cell differentiation|cellular aromatic compound metabolic process|organelle localization|cell development|neuronal cell body|positive regulation of cell activation|transport|organic cyclic compound metabolic process|actin filament|regulation of cell death|apical cortex|apical plasma membrane|cell cortex|multicellular organism development|animal organ development|neurological system process|T cell aggregation|cellular nitrogen compound metabolic process|anion binding|secretion by cell|defense response|regulation of cell adhesion|nucleoside binding|transferase activity, transferring phosphorus-containing groups|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|type 2 immune response|positive regulation of synaptic transmission|cellular component assembly|regulation of cellular response to insulin stimulus|regulation of cytokine production|cell-cell adhesion|regulation of synapse structure or activity|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|cytokine production|cell-cell signaling|response to wounding|regulation of protein localization|14-3-3 protein binding|positive regulation of protein transport|response to transforming growth factor beta|nuclear envelope|movement of cell or subcellular component|establishment of organelle localization|positive regulation of leukocyte activation|cell activation|neuron projection|cell-substrate adhesion|potassium channel regulator activity|regulation of signal transduction|cell activation involved in immune response|cytokine production involved in immune response|establishment of protein localization|somatodendritic compartment|positive regulation of glucose transport|positive regulation of cytokine production|protein domain specific binding|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|establishment or maintenance of cell polarity|cell communication|negative regulation of molecular function|membrane organization|establishment of localization by movement along microtubule|positive regulation of cellular response to insulin stimulus|cell migration|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|developmental cell growth|negative regulation of signal transduction|extracellular exosome|insulin receptor substrate binding|establishment of localization in cell|positive regulation of cell adhesion|response to hormone|cell death|filamentous actin|learning or memory|positive regulation of secretion|regulation of catalytic activity|nucleotide binding|cell projection organization|negative regulation of catalytic activity|cellular developmental process|actin filament-based process|positive regulation of signal transduction|cellular biosynthetic process|microtubule-based process|protein metabolic process|regulation of protein complex assembly|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|apical junction complex|T cell differentiation involved in immune response|endomembrane system organization|regulation of body fluid levels|endosome|leukocyte mediated immunity|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|developmental growth involved in morphogenesis|MAPK cascade|T cell cytokine production|interleukin-13 production|positive regulation of intracellular signal transduction|establishment of vesicle localization|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|negative regulation of protein complex assembly|positive regulation of glucose import|positive regulation of excitatory postsynaptic potential|regulation of gene expression|cellular macromolecule biosynthetic process|platelet activation|positive regulation of interleukin-13 production|regulation of synaptic plasticity|metal ion binding|cell surface receptor signaling pathway|membrane depolarization|purine ribonucleoside triphosphate binding|axon|macromolecule modification|cytoskeleton organization|hemopoiesis|positive regulation of insulin receptor signaling pathway|interleukin-10 production|lymphocyte differentiation|positive regulation of hydrolase activity|membrane hyperpolarization|negative regulation of programmed cell death|blood coagulation|regulation of RNA metabolic process|phospholipase binding|T-helper 2 cell differentiation|microtubule organizing center|regulation of postsynaptic membrane potential|purine nucleoside binding|homotypic cell-cell adhesion|T-helper 2 cell cytokine production|regulation of protein transport|interleukin-4 production|protein transport|response to peptide|regulation of T-helper cell differentiation|cellular response to organonitrogen compound|positive regulation of interleukin-4 production|positive regulation of gene expression|plasma membrane organization|positive regulation of transferase activity|regulation of cytokine production involved in immune response|regulation of interleukin-4 production|protein modification process|negative regulation of cellular protein metabolic process|memory|cellular response to transforming growth factor beta stimulus|regulation of establishment of protein localization|cell-matrix adhesion|wound healing|intracellular transport|inflammatory response|ribonucleoside binding|positive regulation of protein secretion|regulation of type 2 immune response|positive regulation of lymphocyte activation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cytokine secretion|positive regulation of cytokine production involved in immune response|regulation of cell-cell adhesion|regulation of secretion|protein localization to membrane|nuclear lumen|establishment of cell polarity|interleukin-5 production|response to peptide hormone|hemostasis|positive regulation of interleukin-10 production|microtubule-based movement|leukocyte cell-cell adhesion|protein secretion|regulation of cell-substrate adhesion|positive regulation of protein metabolic process|perinuclear region of cytoplasm|negative regulation of hydrolase activity|response to growth factor|nuclear matrix|protein complex assembly|kinase activity|regulation of interleukin-5 production|positive regulation of adaptive immune response|actin cytoskeleton organization|cellular protein localization|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|cytokine secretion|kinase binding|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|long-term synaptic potentiation|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of type 2 immune response|positive regulation of T-helper cell differentiation|gene expression|cell part morphogenesis|nervous system development|secretion|cellular response to organic substance|cognition|purine nucleotide binding|modulation of excitatory postsynaptic potential|regulation of adaptive immune response|vesicle localization|positive regulation of interleukin-5 production|positive regulation of cellular biosynthetic process|negative regulation of insulin receptor signaling pathway|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of cell-substrate adhesion|cell differentiation|nuclear periphery|positive regulation of cell-cell adhesion|cell projection morphogenesis|membrane raft|regulation of insulin receptor signaling pathway|bicellular tight junction|T-helper cell differentiation|regulation of cytokine secretion|regulation of intracellular signal transduction|RNA metabolic process|carbohydrate transport|microtubule cytoskeleton organization|organelle transport along microtubule|axon hillock|phosphotransferase activity, alcohol group as acceptor|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|neuron projection extension|regulation of glucose transport|neuron development|neuron differentiation|leukocyte differentiation|actin cytoskeleton|positive regulation of transcription, DNA-templated|T cell mediated immunity|positive regulation of protein modification process|regulation of T cell activation|actin cytoskeleton reorganization|positive regulation of interleukin-13 secretion|positive regulation of interleukin-10 secretion|protein oligomerization|cellular response to peptide|regulation of MAPK cascade|protein localization to plasma membrane|vesicle transport along microtubule|RNA biosynthetic process|ATP binding|positive regulation of T cell cytokine production|regulation of RNA biosynthetic process|T cell differentiation|regulation of protein secretion|cellular response to growth factor stimulus|adenyl nucleotide binding|regulation of glucose import|phosphorylation|regulation of lymphocyte differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of homotypic cell-cell adhesion|ERK1 and ERK2 cascade|transforming growth factor beta receptor signaling pathway|leukocyte aggregation|alpha-beta T cell activation|CD4-positive, alpha-beta T cell cytokine production|positive regulation of T-helper 2 cell differentiation|enzyme linked receptor protein signaling pathway|regulation of cell-matrix adhesion|positive regulation of interleukin-5 secretion|microtubule cytoskeleton|positive regulation of T-helper 2 cell cytokine production|protein kinase C signaling|cellular response to peptide hormone stimulus|positive regulation of cell-matrix adhesion|positive regulation of MAPK cascade|regulation of apoptotic process|regulation of interleukin-10 secretion|negative regulation of apoptotic process|protein kinase activity|regulation of T cell cytokine production|long-term memory|response to insulin|excitatory postsynaptic potential|protein kinase binding|neurogenesis|cellular protein modification process|positive regulation of T cell activation|cytoskeleton-dependent intracellular transport|neuron projection morphogenesis|positive regulation of lymphocyte differentiation|protein localization to cell periphery|positive regulation of lipase activity|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|interleukin-10 secretion|positive regulation of T cell differentiation|regulation of protein kinase activity|hexose transport|positive regulation of protein kinase activity|positive regulation of T cell mediated immunity|regulation of phospholipase activity|protein phosphorylation|alpha-beta T cell differentiation|generation of neurons|protein heterooligomerization|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|cellular response to insulin stimulus|peptidyl-amino acid modification|negative regulation of phosphorylation|protein serine/threonine kinase activity|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|positive regulation of phospholipase activity|CD4-positive, alpha-beta T cell activation|negative regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|lymphocyte aggregation|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|regulation of peptidyl-tyrosine phosphorylation|activation of phospholipase D activity|positive regulation of alpha-beta T cell differentiation|glucose transport|peptidyl-serine phosphorylation|CD4-positive, alpha-beta T cell differentiation|negative regulation of peptidyl-tyrosine phosphorylation|protein kinase C activity|positive regulation of CD4-positive, alpha-beta T cell activation|activation of protein kinase activity|insulin receptor signaling pathway|peptidyl-tyrosine phosphorylation|glucose import|activation of protein kinase B activity|positive regulation of CD4-positive, alpha-beta T cell differentiation|regulation of CD4-positive, alpha-beta T cell differentiation K18952 atypical protein kinase C zeta type[2.7.11.13] hsa04144|hsa04015|hsa04062|hsa04390|hsa04910|hsa04530|hsa04611|hsa04071|hsa04931|hsa04933|hsa04930 Endocytosis - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Insulin signaling pathway - Homo sapiens (human)|Tight junction - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Insulin resistance - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Type II diabetes mellitus - Homo sapiens (human) 1:2050470-2185395 131 112 292 347 397 440 0.771246561995627 0.599265737233107 1.54995621677605 1.83041352435565 1.9176997586617 2.42774821782912 0.973489505334928 2.05862050028216 -1.08044056731073 0.000909317705126354 0.00546212691525999 DOWN ENSG00000162512 SDC3 syndecan 3 [Source:HGNC Symbol;Acc:HGNC:10660] GO:0040011|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0051606|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0009628|GO:0009986|GO:0044237|GO:0048870|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0044255|GO:0009314|GO:0006082|GO:0043062|GO:0044281|GO:0009582|GO:0043231|GO:0005737|GO:0005975|GO:0006928|GO:0043005|GO:0007154|GO:0006629|GO:0016477|GO:0007165|GO:0016021|GO:0019538|GO:0005794|GO:0006790|GO:0030424|GO:0009583|GO:0006720|GO:0005773|GO:0030204|GO:0009100|GO:0005796|GO:0007602|GO:1901137|GO:0005775|GO:0030198|GO:0009059|GO:0009416|GO:0000323|GO:0043202|GO:0009584|GO:0006024|GO:0006029|GO:0007603|GO:0030203|GO:0005764|GO:0006027|GO:0016101|GO:0001523 locomotion|macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|detection of stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|response to abiotic stimulus|cell surface|cellular metabolic process|cell motility|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|cellular lipid metabolic process|response to radiation|organic acid metabolic process|extracellular structure organization|small molecule metabolic process|detection of abiotic stimulus|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|movement of cell or subcellular component|neuron projection|cell communication|lipid metabolic process|cell migration|signal transduction|integral component of membrane|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|axon|detection of light stimulus|isoprenoid metabolic process|vacuole|chondroitin sulfate metabolic process|glycoprotein metabolic process|Golgi lumen|phototransduction|carbohydrate derivative biosynthetic process|vacuolar lumen|extracellular matrix organization|macromolecule biosynthetic process|response to light stimulus|lytic vacuole|lysosomal lumen|detection of visible light|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|phototransduction, visible light|glycosaminoglycan metabolic process|lysosome|glycosaminoglycan catabolic process|diterpenoid metabolic process|retinoid metabolic process K16337 syndecan 3[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 1:30869467-30908761 89 161 243 341 387 321 0.740134643387812 1.21682177984811 1.82196482140866 2.54081041376583 2.64057874557636 2.50181094553995 1.25964041488153 2.56106670162738 -1.02373287623506 0.000912294029155328 0.00547559830044293 DOWN ENSG00000224097 RP11-472B18.1 - - - - - - - 4:39480255-39481905 15 14 9 3 5 3 0.270465606601306 0.22942192941804 0.14630871623593 0.0484604890936736 0.073973972782028 0.0506900933298889 0.215398750751759 0.0577081850685302 1.90016201885726 0.000913079978632891 0.0054781128782368 UP ENSG00000162949 CAPN13 calpain 13 [Source:HGNC Symbol;Acc:HGNC:16663] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0043167|GO:0016787|GO:0005622|GO:0043169|GO:0008233|GO:0019538|GO:0046872|GO:0006508|GO:0005509|GO:0004175|GO:0008234|GO:0004197|GO:0004198 cell|metabolic process|binding|catalytic activity|organic substance metabolic process|ion binding|hydrolase activity|intracellular|cation binding|peptidase activity|protein metabolic process|metal ion binding|proteolysis|calcium ion binding|endopeptidase activity|cysteine-type peptidase activity|cysteine-type endopeptidase activity|calcium-dependent cysteine-type endopeptidase activity - - - - 2:30722771-30820542 8 7 15 25 26 39 0.0889450650086955 0.0707390033340705 0.15036740109617 0.249055211578882 0.237190283300047 0.406396833304466 0.103350489812979 0.297547442727798 -1.52557449240932 0.00091458053021099 0.00548380942938721 DOWN ENSG00000264577 AC010761.8 - - - - - - - 17:28721487-28722877 58 75 58 31 43 26 4.56367678958873 5.36326816528151 4.11463878471151 2.18543965905874 2.77598941100937 1.91728690775515 4.68052791319392 2.29290532594109 1.02949447219406 0.000914863791179859 0.00548440634977581 UP ENSG00000186352 ANKRD37 ankyrin repeat domain 37 [Source:HGNC Symbol;Acc:HGNC:29593] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005634 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|nucleus - - - - 4:185396021-185400628 96 75 233 66 66 46 1.58922381178758 1.12838241998317 3.4776314063395 0.97893939518535 0.896453457242483 0.713666480488425 2.06507921270342 0.863019777638753 1.25873159505054 0.00091699950154041 0.00549428247799382 UP ENSG00000260757 RP11-120K18.2 - - - - - - - 16:31402565-31404699 1 0 3 9 8 8 0.0400490624915755 0 0.108263034416113 0.322804535571867 0.262779545346927 0.300145149842754 0.0494373656358962 0.295243076920516 -2.5782294569791 0.000916904374024555 0.00549428247799382 DOWN ENSG00000278383 RP4-694B14.8 - - - - - - - 20:25680781-25681246 7 2 4 18 15 18 1.06259242727812 0.275911167721328 0.547451090100545 2.44804984701927 1.86823966882336 2.56069624527839 0.628651561699998 2.29232858704034 -1.86648134649962 0.000917341139483676 0.00549484397635346 DOWN ENSG00000244161 FLNB-AS1 FLNB antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40239] - - - - - - 3:58162547-58170636 28 32 75 103 128 97 0.462758416705028 0.480652725824819 1.11758265822965 1.52523444036491 1.73572347116958 1.50245163221801 0.686997933586499 1.58780318125083 -1.20865442723611 0.000918760190864614 0.00550003343454425 DOWN ENSG00000184156 KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3 [Source:HGNC Symbol;Acc:HGNC:6297] GO:0040011|GO:0032502|GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0042995|GO:0022857|GO:0050794|GO:0009986|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0042391|GO:0006935|GO:0048468|GO:0006810|GO:0098797|GO:0007275|GO:0005887|GO:0007267|GO:0006928|GO:0043005|GO:0022891|GO:0031226|GO:0005516|GO:1902495|GO:0007154|GO:0055085|GO:0071804|GO:0030030|GO:0048869|GO:0016021|GO:0000902|GO:0031175|GO:0030424|GO:0060081|GO:0043194|GO:0000904|GO:0015267|GO:0006811|GO:0044304|GO:0015075|GO:0008076|GO:0034765|GO:0034702|GO:0043269|GO:0032990|GO:0007399|GO:0097485|GO:0071805|GO:0030154|GO:0048858|GO:0033268|GO:0034220|GO:0048666|GO:0030182|GO:0007411|GO:0098655|GO:0005216|GO:0034703|GO:0006812|GO:0061564|GO:0022008|GO:0048667|GO:0048812|GO:0008324|GO:0005244|GO:0007409|GO:0048699|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0007268|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249|GO:0005251 locomotion|developmental process|macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cell projection|transmembrane transporter activity|regulation of cellular process|cell surface|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|protein complex|anatomical structure development|regulation of membrane potential|chemotaxis|cell development|transport|plasma membrane protein complex|multicellular organism development|integral component of plasma membrane|cell-cell signaling|movement of cell or subcellular component|neuron projection|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|calmodulin binding|transmembrane transporter complex|cell communication|transmembrane transport|cellular potassium ion transport|cell projection organization|cellular developmental process|integral component of membrane|cell morphogenesis|neuron projection development|axon|membrane hyperpolarization|axon initial segment|cell morphogenesis involved in differentiation|channel activity|ion transport|main axon|ion transmembrane transporter activity|voltage-gated potassium channel complex|regulation of ion transmembrane transport|ion channel complex|regulation of ion transport|cell part morphogenesis|nervous system development|neuron projection guidance|potassium ion transmembrane transport|cell differentiation|cell projection morphogenesis|node of Ranvier|ion transmembrane transport|neuron development|neuron differentiation|axon guidance|cation transmembrane transport|ion channel activity|cation channel complex|cation transport|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|cation transmembrane transporter activity|voltage-gated ion channel activity|axonogenesis|generation of neurons|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|synaptic transmission|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity|delayed rectifier potassium channel activity K04928 potassium voltage-gated channel KQT-like subfamily member 3[-] hsa04725 Cholinergic synapse - Homo sapiens (human) 8:132120859-132480953 0 0 1 5 5 6 0 0 0.00251418623569632 0.012497917643297 0.0114459215596709 0.0156892399233537 0.00083806207856544 0.0132110263754405 -3.97854163087306 0.00092354345664027 0.00552755941350013 DOWN ENSG00000181350 LRRC75A leucine rich repeat containing 75A [Source:HGNC Symbol;Acc:HGNC:32403] - - - - - - 17:16441577-16492153 34 28 39 82 82 66 0.339987795043173 0.254459210943447 0.351613041234798 0.734667452519693 0.672766527382561 0.618521816360278 0.315353349073806 0.675318598754177 -1.09859903609825 0.000924613693045851 0.00553285572102442 DOWN ENSG00000259087 RP11-356O9.2 - - - - - - - 14:37556158-37567095 4 8 4 18 20 19 0.531831300362143 0.966726347053676 0.479534225539199 2.14434441487026 2.1818448487719 2.36761314976964 0.659363957651673 2.23126747113727 -1.75871653243873 0.000925145923464066 0.00553493114210345 DOWN ENSG00000167037 SGSM1 small G protein signaling modulator 1 [Source:HGNC Symbol;Acc:HGNC:29410] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0043231|GO:0005737|GO:0005794 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|Golgi apparatus - - - - 22:24806169-24927578 9 18 46 63 52 146 0.0486947527159197 0.0885093649551209 0.224393731336629 0.305402586714125 0.23084053577404 0.740318005958672 0.12053261633589 0.425520376148946 -1.81980462229966 0.000929260314310729 0.00555843266348076 DOWN ENSG00000215319 EIF5P1 eukaryotic translation initiation factor 5 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:51465] - - - - - - X:9818239-9819469 13 18 10 6 0 4 0.747010112754342 0.940025538117994 0.518099528811645 0.308923733258333 0 0.215388287173739 0.73504505989466 0.174770673477357 2.07236957218079 0.000929490096926608 0.00555869338013761 UP ENSG00000267707 RP11-95O2.5 - - - - - - - 18:37243776-37247506 1 0 0 6 5 5 0.100951060517281 0 0 0.542489465964348 0.413979879064045 0.472894784078448 0.0336503535057603 0.47645470970228 -3.82364551664835 0.00093898608105323 0.00560874158938838 DOWN ENSG00000259456 ADNP-AS1 ADNP antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51227] - - - - - - 20:50930984-50945134 27 36 58 15 25 14 1.3740327992977 1.66499487399029 2.66119443701845 0.683942971220502 1.04384270127377 0.667727675387667 1.90007403676881 0.79850444929398 1.25068328303784 0.000942853366286693 0.00562958887942458 UP ENSG00000182870 GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 [Source:HGNC Symbol;Acc:HGNC:4131] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0034645|GO:0046872|GO:0043412|GO:0008194|GO:0006493|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0008376|GO:0006464|GO:0016266|GO:0004653|GO:0043687 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|endomembrane system|transferase activity|organelle membrane|protein glycosylation|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|UDP-glycosyltransferase activity|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|acetylgalactosaminyltransferase activity|cellular protein modification process|O-glycan processing|polypeptide N-acetylgalactosaminyltransferase activity|post-translational protein modification K00710 polypeptide N-acetylgalactosaminyltransferase[2.4.1.41] hsa01100|hsa00512 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human) 12:132196372-132329349 21 15 33 58 51 63 0.150461279584201 0.0976744612421667 0.213171512378677 0.372324644461898 0.299802080130198 0.423021936194576 0.153769084401682 0.365049553595557 -1.24732684012528 0.000944584821580947 0.00563568320399763 DOWN ENSG00000234112 RP11-145A3.4 - - - - - - - 1:225803148-225803448 7 4 10 1 2 0 1.64507664821131 0.854316306698598 2.11887215935925 0.21046110797612 0.385609082457713 0 1.53942170475639 0.198690063477944 2.95379686344614 0.000945887241467306 0.00564206147987312 UP ENSG00000147082 CCNB3 cyclin B3 [Source:HGNC Symbol;Acc:HGNC:18709] GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0044702|GO:0051321|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0019222|GO:0051726|GO:0007049|GO:0022402|GO:0043231|GO:0019899|GO:0050790|GO:0051301|GO:0019538|GO:0031323|GO:0032268|GO:1903047|GO:0043412|GO:0044770|GO:0036211|GO:0000278|GO:0031981|GO:0007346|GO:0010564|GO:0005654|GO:0019900|GO:0006796|GO:0044267|GO:0051174|GO:0051246|GO:0005634|GO:0000086|GO:0044772|GO:0016310|GO:1901990|GO:1901987|GO:0019901|GO:0006464|GO:0000079|GO:0043549|GO:0045859|GO:0010389|GO:0006468|GO:0042325|GO:0001932|GO:1902749|GO:0071900 reproduction|cell|cellular process|reproductive process|metabolic process|binding|regulation of cellular process|intracellular organelle|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|regulation of metabolic process|regulation of cell cycle|cell cycle|cell cycle process|intracellular membrane-bounded organelle|enzyme binding|regulation of catalytic activity|cell division|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|mitotic cell cycle process|macromolecule modification|cell cycle phase transition|protein modification process|mitotic cell cycle|nuclear lumen|regulation of mitotic cell cycle|regulation of cell cycle process|nucleoplasm|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|nucleus|G2/M transition of mitotic cell cycle|mitotic cell cycle phase transition|phosphorylation|regulation of mitotic cell cycle phase transition|regulation of cell cycle phase transition|protein kinase binding|cellular protein modification process|regulation of cyclin-dependent protein serine/threonine kinase activity|regulation of kinase activity|regulation of protein kinase activity|regulation of G2/M transition of mitotic cell cycle|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|regulation of cell cycle G2/M phase transition|regulation of protein serine/threonine kinase activity K05868 cyclin B[-] hsa04068|hsa04110|hsa04914|hsa04115 FoxO signaling pathway - Homo sapiens (human)|Cell cycle - Homo sapiens (human)|Progesterone-mediated oocyte maturation - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) X:50202713-50351910 20 16 12 46 42 42 0.239623563670765 0.174220330837587 0.12963018698519 0.493799285821529 0.412874216507792 0.4716046561003 0.181158027164514 0.459426052809874 -1.34258393693097 0.000947118328798319 0.0056482761861656 DOWN ENSG00000111319 SCNN1A sodium channel, non voltage gated 1 alpha subunit [Source:HGNC Symbol;Acc:HGNC:10599] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0042995|GO:0004872|GO:0022857|GO:0043229|GO:0045177|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0005929|GO:0031090|GO:0006810|GO:0016324|GO:0005938|GO:0050877|GO:0060170|GO:0031982|GO:0005887|GO:0031514|GO:0005737|GO:0042592|GO:0022891|GO:0048871|GO:0019904|GO:0031226|GO:1902495|GO:0055085|GO:0070062|GO:0008092|GO:0031253|GO:0016021|GO:0050878|GO:0030864|GO:0050891|GO:0048878|GO:0003779|GO:0050699|GO:0015267|GO:0006811|GO:0015075|GO:0007600|GO:0034702|GO:0005856|GO:0034220|GO:0015629|GO:0015276|GO:0098655|GO:0005216|GO:0034703|GO:0006812|GO:0030104|GO:0050801|GO:0030863|GO:0007606|GO:0008324|GO:0050909|GO:0015280|GO:0034706|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0005272|GO:0035725|GO:0006814|GO:0055065|GO:0015077|GO:0046873|GO:0055078|GO:0015081 macromolecular complex|transporter activity|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cell projection|receptor activity|transmembrane transporter activity|intracellular organelle|apical part of cell|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|cilium|organelle membrane|transport|apical plasma membrane|cell cortex|neurological system process|ciliary membrane|vesicle|integral component of plasma membrane|motile cilium|cytoplasm|homeostatic process|substrate-specific transmembrane transporter activity|multicellular organismal homeostasis|protein domain specific binding|intrinsic component of plasma membrane|transmembrane transporter complex|transmembrane transport|extracellular exosome|cytoskeletal protein binding|cell projection membrane|integral component of membrane|regulation of body fluid levels|cortical actin cytoskeleton|multicellular organismal water homeostasis|chemical homeostasis|actin binding|WW domain binding|channel activity|ion transport|ion transmembrane transporter activity|sensory perception|ion channel complex|cytoskeleton|ion transmembrane transport|actin cytoskeleton|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|cation channel complex|cation transport|water homeostasis|ion homeostasis|cortical cytoskeleton|sensory perception of chemical stimulus|cation transmembrane transporter activity|sensory perception of taste|ligand-gated sodium channel activity|sodium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|sodium channel activity|sodium ion transmembrane transport|sodium ion transport|metal ion homeostasis|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|sodium ion homeostasis|sodium ion transmembrane transporter activity K04824 amiloride-sensitive sodium channel subunit alpha[-] hsa04742|hsa04960 Taste transduction - Homo sapiens (human)|Aldosterone-regulated sodium reabsorption - Homo sapiens (human) 12:6346843-6377730 1368 1455 2356 3597 2249 5001 6.25480058545762 6.04603300680857 9.71218532090623 14.7355222481058 8.43693498343633 21.4295531973825 7.33767297105747 14.8673368096415 -1.01875172774789 0.000947840073415083 0.00565145147827719 DOWN ENSG00000259305 ZHX1-C8orf76 ZHX1-C8orf76 readthrough [Source:HGNC Symbol;Acc:HGNC:42975] GO:0005488|GO:0005515 binding|protein binding - - - - 8:123226189-123274284 23 19 12 45 52 51 1.01812974920597 0.764386210363073 0.478934057547285 1.78475731538767 1.88861649856683 2.11576728082981 0.753816672372109 1.92971369826144 -1.35610120914205 0.000954917358449697 0.00568796943718222 DOWN ENSG00000137821 LRRC49 leucine rich repeat containing 49 [Source:HGNC Symbol;Acc:HGNC:25965] GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0005874|GO:0005737|GO:0005856|GO:0015630 cell|binding|intracellular organelle|intracellular|protein binding|microtubule|cytoplasm|cytoskeleton|microtubule cytoskeleton - - - - 15:70853239-71053657 33 43 39 77 98 80 0.1266373877672 0.149969316663476 0.134937918607658 0.264751551847022 0.308563728455018 0.287717369987038 0.137181541012778 0.287010883429693 -1.06501907760039 0.000960839667770089 0.00571982202225488 DOWN ENSG00000269974 RP11-932O9.10 - - - - - - - 15:30648797-30649529 1 1 2 7 17 5 0.0965439200854214 0.0877458754937781 0.17401924146443 0.605230435391297 1.34606823941536 0.452249991321954 0.11943634568121 0.801182888709537 -2.74588967904477 0.000961631576842681 0.00572339495515578 DOWN ENSG00000250135 RP4-622L5.2 - - - - - - - 1:32170733-32176568 6 11 0 0 0 0 0.6362839245712 1.0602559932948 0 0 0 0 0.565513305955333 0 Inf 0.000974946310255749 0.00579455447867313 UP ENSG00000234111 RP11-364P22.1 - - - - - - - 4:157572490-157576154 0 1 1 7 6 6 0 0.0252028709784245 0.0249783220297196 0.173837738691936 0.136443966089073 0.155871860899965 0.016727064336048 0.155384521893658 -3.21558662749884 0.000977315466892079 0.00580632357185993 DOWN ENSG00000249631 RP11-281P23.2 - - - - - - - 4:11625714-11813958 1 0 4 8 8 13 0.0251570186358386 0 0.0906904400948646 0.180251269411546 0.165066283906157 0.306383122435528 0.0386158195769011 0.21723355858441 -2.49198309379596 0.000980175839340255 0.00582100049883906 DOWN ENSG00000223522 AC093690.1 - - - - - - - 2:28307691-28310459 0 0 3 6 7 10 0 0 0.0906638776366216 0.18022991262607 0.192544184380885 0.314183872287954 0.0302212925455405 0.22898598976497 -2.92162206135677 0.000982249689954568 0.00582987238449548 DOWN ENSG00000243566 UPK3B uroplakin 3B [Source:HGNC Symbol;Acc:HGNC:21444] GO:0005623|GO:0016020|GO:0005576|GO:0008152|GO:1903561|GO:0009892|GO:0071704|GO:0043227|GO:0071944|GO:0031224|GO:0005886|GO:0019222|GO:0031982|GO:0070062|GO:0016021|GO:0010468|GO:0010629|GO:0010467 cell|membrane|extracellular region|metabolic process|extracellular vesicle|negative regulation of metabolic process|organic substance metabolic process|membrane-bounded organelle|cell periphery|intrinsic component of membrane|plasma membrane|regulation of metabolic process|vesicle|extracellular exosome|integral component of membrane|regulation of gene expression|negative regulation of gene expression|gene expression - - - - 7:76510428-76516521 54 70 154 211 188 254 0.912956783472181 1.07555237703988 2.34740750814506 3.19619479289001 2.60783435865073 4.02454465307181 1.44530555621904 3.27619126820418 -1.18064505651123 0.000983271967558383 0.0058347448458533 DOWN ENSG00000228998 RP11-697E2.7 - - - - - - - 15:90275129-90275716 13 17 17 7 7 1 1.56389362040917 1.858698231296 1.84386651320963 0.754479437316021 0.690932362319162 0.112730859485915 1.75548612163827 0.519380886373699 1.75700576294679 0.000985554436286739 0.00584440095681012 UP ENSG00000269834 ZNF528-AS1 ZNF528 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51305] - - - - - - 19:52388842-52397766 18 16 12 7 5 3 0.2347474915221 0.189638059230293 0.141101884948481 0.0817909124524005 0.053502930535379 0.0366624697885609 0.188495811900291 0.0573187709254468 1.71745288965518 0.000985682281018924 0.00584440095681012 UP ENSG00000134962 KLB klotho beta [Source:HGNC Symbol;Acc:HGNC:15527] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0008283|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0016787|GO:0031224|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0006935|GO:0045087|GO:0048468|GO:0019838|GO:0007275|GO:0005102|GO:0016798|GO:0006952|GO:0031325|GO:0010243|GO:0005975|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0007154|GO:0007165|GO:0009725|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0007166|GO:0070851|GO:0043412|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0032270|GO:0006796|GO:0004553|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0017134|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:0005104|GO:1901653|GO:0043408|GO:0090080|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0048017|GO:0007167|GO:0071375|GO:0043410|GO:0032868|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:0048015|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0042327|GO:0007169|GO:0048010|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell proliferation|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|hydrolase activity|intrinsic component of membrane|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|chemotaxis|innate immune response|cell development|growth factor binding|multicellular organism development|receptor binding|hydrolase activity, acting on glycosyl bonds|defense response|positive regulation of cellular metabolic process|response to organonitrogen compound|carbohydrate metabolic process|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|cell communication|signal transduction|response to hormone|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|cell surface receptor signaling pathway|growth factor receptor binding|macromolecule modification|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|fibroblast growth factor binding|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor binding|cellular response to peptide|regulation of MAPK cascade|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|response to insulin|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 4:39406853-39451536 15 13 9 6 1 3 0.174455207940961 0.137416203828637 0.0943717681344217 0.0625263261494588 0.00954673258539172 0.0326960269867074 0.13541439330134 0.0349230285738526 1.95513051020692 0.000990299932907291 0.00586944891741399 UP ENSG00000244879 GABPB1-AS1 GABPB1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44157] - - - - - - 15:50354959-50372202 90 95 250 20 68 73 0.32242520684378 0.309309907428183 0.807501266601973 0.06419614757785 0.199879157083662 0.245099724655712 0.479745460291312 0.169725009772408 1.49906998623747 0.000993736062336097 0.00588747696070288 UP ENSG00000279970 RP11-299G20.5 - - - - - - - 15:101299656-101301648 0 3 4 11 16 8 0 0.0967849126417854 0.128004118407855 0.34980297018021 0.465933162020625 0.266109623568563 0.0749296770165468 0.360615251923133 -2.26685127777271 0.000997197105620002 0.00590563824462995 DOWN ENSG00000171116 HSFX1 heat shock transcription factor family, X-linked 1 [Source:HGNC Symbol;Acc:HGNC:29603] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:149774068-149776867 26 16 25 5 10 11 0.936902138360259 0.52399227369593 0.812235316220565 0.161422416672517 0.295669786269889 0.371479223589048 0.757709909425585 0.276190475510485 1.455982046965 0.00100356007091291 0.00594096417946344 UP ENSG00000182963 GJC1 gap junction protein gamma 1 [Source:HGNC Symbol;Acc:HGNC:4280] GO:0032502|GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0022857|GO:0043229|GO:0042175|GO:0005911|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0048514|GO:0007507|GO:0042391|GO:0009888|GO:0048468|GO:0006810|GO:0001568|GO:0098797|GO:0007275|GO:0048513|GO:0050877|GO:0044291|GO:0022607|GO:0043231|GO:0005737|GO:0003012|GO:0007267|GO:0006928|GO:0022891|GO:0007154|GO:0055085|GO:0061024|GO:0005783|GO:0048869|GO:0016021|GO:0030029|GO:0003013|GO:0005921|GO:0006936|GO:0045216|GO:0086019|GO:0001944|GO:0072358|GO:0061337|GO:0030048|GO:0048738|GO:0014704|GO:0001508|GO:0060537|GO:0015267|GO:0006811|GO:0034329|GO:0015075|GO:0007600|GO:0001570|GO:0005922|GO:0030154|GO:0072359|GO:0008015|GO:0086065|GO:0034220|GO:0006941|GO:0008016|GO:0050953|GO:0070252|GO:0086001|GO:0005216|GO:0060047|GO:0022829|GO:0086066|GO:0014706|GO:0007043|GO:0086003|GO:0016264|GO:0005243|GO:0086002|GO:0060048|GO:0007601|GO:0007268|GO:0086014 developmental process|macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|cell junction|binding|transmembrane transporter activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|cell-cell junction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|blood vessel morphogenesis|heart development|regulation of membrane potential|tissue development|cell development|transport|blood vessel development|plasma membrane protein complex|multicellular organism development|animal organ development|neurological system process|cell-cell contact zone|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|muscle system process|cell-cell signaling|movement of cell or subcellular component|substrate-specific transmembrane transporter activity|cell communication|transmembrane transport|membrane organization|endoplasmic reticulum|cellular developmental process|integral component of membrane|actin filament-based process|circulatory system process|gap junction|muscle contraction|cell-cell junction organization|cell-cell signaling involved in cardiac conduction|vasculature development|cardiovascular system development|cardiac conduction|actin filament-based movement|cardiac muscle tissue development|intercalated disc|action potential|muscle tissue development|channel activity|ion transport|cell junction assembly|ion transmembrane transporter activity|sensory perception|vasculogenesis|connexon complex|cell differentiation|circulatory system development|blood circulation|cell communication involved in cardiac conduction|ion transmembrane transport|striated muscle contraction|regulation of heart contraction|sensory perception of light stimulus|actin-mediated cell contraction|cardiac muscle cell action potential|ion channel activity|heart contraction|wide pore channel activity|atrial cardiac muscle cell to AV node cell communication|striated muscle tissue development|cell-cell junction assembly|cardiac muscle cell contraction|gap junction assembly|gap junction channel activity|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|visual perception|synaptic transmission|atrial cardiac muscle cell action potential - - - - 17:44798448-44830816 157 148 244 57 149 61 0.615238288182297 0.527091059093805 0.862082111632357 0.200133644743865 0.479070474972954 0.224027704021584 0.668137152969486 0.301077274579468 1.15001046769936 0.00100938945357224 0.0059683724988999 UP ENSG00000249572 CTD-2203K17.1 - - - - - - - 5:33424025-33440619 2 2 6 17 16 9 0.263439713028548 0.239431292659477 0.712603932924173 2.00641049387368 1.72924542254582 1.11106559618224 0.405158312870733 1.61557383753391 -1.99548904185668 0.00101129342175239 0.00597607953543072 DOWN ENSG00000269356 RP11-120K24.4 - - - - - - - 13:113008778-113009424 0 0 0 10 0 7 0 0 0 0.979611323135003 0 0.717265431830647 0 0.56562558498855 -Inf 0.00101125749113691 0.00597607953543072 DOWN ENSG00000135423 GLS2 glutaminase 2 [Source:HGNC Symbol;Acc:HGNC:29570] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0016043|GO:0043227|GO:0016787|GO:0009058|GO:0005622|GO:0007269|GO:1903829|GO:0005515|GO:0060341|GO:0006725|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0006082|GO:0034641|GO:0044281|GO:0032940|GO:0046483|GO:0051128|GO:0043231|GO:0005737|GO:0006520|GO:0007267|GO:0032880|GO:0016810|GO:0051222|GO:0072593|GO:0045184|GO:0032388|GO:0006139|GO:0008104|GO:0007154|GO:0051649|GO:0008219|GO:0001505|GO:0090316|GO:0044249|GO:0006996|GO:0006836|GO:0034645|GO:0072594|GO:0007005|GO:0032386|GO:0051223|GO:0016811|GO:1903955|GO:0015031|GO:0070201|GO:0046907|GO:0006811|GO:0009063|GO:0008652|GO:0005759|GO:0005739|GO:0034613|GO:0012501|GO:0033043|GO:0010467|GO:0046903|GO:0006626|GO:0009059|GO:1903827|GO:0016070|GO:0014047|GO:0043067|GO:0010638|GO:0006820|GO:0015711|GO:0033365|GO:0033157|GO:0032774|GO:0006839|GO:0046395|GO:0006605|GO:0072655|GO:0010822|GO:0004359|GO:0046942|GO:0016482|GO:0006886|GO:0010821|GO:0042981|GO:0019752|GO:0006865|GO:1903214|GO:0046717|GO:0006351|GO:0006915|GO:1903533|GO:0006366|GO:0006541|GO:0006352|GO:0043648|GO:0006835|GO:0070585|GO:0007268|GO:0006536|GO:0006367|GO:0006543|GO:0006537 signaling|cell|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|cellular component organization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intracellular|neurotransmitter secretion|positive regulation of cellular protein localization|protein binding|regulation of cellular localization|cellular aromatic compound metabolic process|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|secretion by cell|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|cell-cell signaling|regulation of protein localization|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|positive regulation of protein transport|reactive oxygen species metabolic process|establishment of protein localization|positive regulation of intracellular transport|nucleobase-containing compound metabolic process|protein localization|cell communication|establishment of localization in cell|cell death|regulation of neurotransmitter levels|positive regulation of intracellular protein transport|cellular biosynthetic process|organelle organization|neurotransmitter transport|cellular macromolecule biosynthetic process|establishment of protein localization to organelle|mitochondrion organization|regulation of intracellular transport|regulation of protein transport|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|positive regulation of protein targeting to mitochondrion|protein transport|regulation of establishment of protein localization|intracellular transport|ion transport|cellular amino acid catabolic process|cellular amino acid biosynthetic process|mitochondrial matrix|mitochondrion|cellular protein localization|programmed cell death|regulation of organelle organization|gene expression|secretion|protein targeting to mitochondrion|macromolecule biosynthetic process|regulation of cellular protein localization|RNA metabolic process|glutamate secretion|regulation of programmed cell death|positive regulation of organelle organization|anion transport|organic anion transport|protein localization to organelle|regulation of intracellular protein transport|RNA biosynthetic process|mitochondrial transport|carboxylic acid catabolic process|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|glutaminase activity|carboxylic acid transport|cytosolic transport|intracellular protein transport|regulation of mitochondrion organization|regulation of apoptotic process|carboxylic acid metabolic process|amino acid transport|regulation of protein targeting to mitochondrion|acid secretion|transcription, DNA-templated|apoptotic process|regulation of protein targeting|transcription from RNA polymerase II promoter|glutamine metabolic process|DNA-templated transcription, initiation|dicarboxylic acid metabolic process|dicarboxylic acid transport|protein localization to mitochondrion|synaptic transmission|glutamate metabolic process|transcription initiation from RNA polymerase II promoter|glutamine catabolic process|glutamate biosynthetic process K01425 glutaminase[3.5.1.2] hsa01100|hsa05206|hsa04724|hsa04727|hsa05230|hsa00250|hsa04964|hsa00220|hsa00471 Metabolic pathways - Homo sapiens (human)|MicroRNAs in cancer - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Alanine, aspartate and glutamate metabolism - Homo sapiens (human)|Proximal tubule bicarbonate reclamation - Homo sapiens (human)|Arginine biosynthesis - Homo sapiens (human)|D-Glutamine and D-glutamate metabolism - Homo sapiens (human) 12:56470944-56488414 7 10 29 43 42 51 0.0509904305541761 0.0662004964257744 0.190457227240019 0.280638501161139 0.251015278988982 0.348161478196482 0.10254938473999 0.293271752782201 -1.51591928474521 0.00101529035950609 0.00599376673772888 DOWN ENSG00000147606 SLC26A7 solute carrier family 26 (anion exchanger), member 7 [Source:HGNC Symbol;Acc:HGNC:14467] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0031090|GO:0042391|GO:0016323|GO:0006810|GO:0005887|GO:0043231|GO:0005737|GO:0042592|GO:0001696|GO:0019725|GO:0022891|GO:0031226|GO:0055085|GO:0007586|GO:0010008|GO:0016021|GO:0005768|GO:0048878|GO:0015267|GO:0006811|GO:0055082|GO:0015075|GO:0055037|GO:0046903|GO:0015116|GO:0034220|GO:0055038|GO:0006820|GO:0015711|GO:0005216|GO:0098656|GO:0015297|GO:0008509|GO:0008272|GO:0046942|GO:0046943|GO:0050801|GO:0008271|GO:0046717|GO:0006873|GO:1902358|GO:0005253|GO:0006835|GO:0015301|GO:0008514|GO:0015701|GO:0015698|GO:0030003|GO:0005310|GO:0005254|GO:0015106|GO:1902476|GO:0006821|GO:0019532|GO:0019531|GO:0015108|GO:0006885|GO:0030641|GO:0051453 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|organelle membrane|regulation of membrane potential|basolateral plasma membrane|transport|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|gastric acid secretion|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|digestion|endosome membrane|integral component of membrane|endosome|chemical homeostasis|channel activity|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|recycling endosome|secretion|sulfate transmembrane transporter activity|ion transmembrane transport|recycling endosome membrane|anion transport|organic anion transport|ion channel activity|anion transmembrane transport|antiporter activity|anion transmembrane transporter activity|sulfate transport|carboxylic acid transport|carboxylic acid transmembrane transporter activity|ion homeostasis|secondary active sulfate transmembrane transporter activity|acid secretion|cellular ion homeostasis|sulfate transmembrane transport|anion channel activity|dicarboxylic acid transport|anion:anion antiporter activity|organic anion transmembrane transporter activity|bicarbonate transport|inorganic anion transport|cellular cation homeostasis|dicarboxylic acid transmembrane transporter activity|chloride channel activity|bicarbonate transmembrane transporter activity|chloride transmembrane transport|chloride transport|oxalate transport|oxalate transmembrane transporter activity|chloride transmembrane transporter activity|regulation of pH|regulation of cellular pH|regulation of intracellular pH K13962 solute carrier family 26 (anion exchange transporter), member 7[-] hsa04971 Gastric acid secretion - Homo sapiens (human) 8:91209494-91398152 0 0 0 4 2 6 0 0 0 0.0172770485503161 0.00790979513559845 0.027108149721733 0 0.0174316644692158 -Inf 0.00101691779696194 0.0060010009706467 DOWN ENSG00000168939 SPRY3 sprouty RTK signaling antagonist 3 [Source:HGNC Symbol;Acc:HGNC:11271] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0023051|GO:0016043|GO:0005622|GO:0048856|GO:0048468|GO:0007275|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0030030|GO:0048869|GO:0031175|GO:0007399|GO:0030154|GO:0048666|GO:0030182|GO:0061564|GO:0022008|GO:0048699 developmental process|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of signaling|cellular component organization|intracellular|anatomical structure development|cell development|multicellular organism development|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|cell projection organization|cellular developmental process|neuron projection development|nervous system development|cell differentiation|neuron development|neuron differentiation|axon development|neurogenesis|generation of neurons - - - - X:155767812-155782459 17 23 50 73 70 81 0.133330047742904 0.163947042075227 0.353568671857405 0.512988351787207 0.450458176121152 0.595393119314689 0.216948587225179 0.519613215741016 -1.26008493315849 0.00101837148662849 0.0060083917711081 DOWN ENSG00000279145 RP11-547D13.1 - - - - - - - 15:55171972-55178175 14 17 21 4 5 9 0.170190091463002 0.187818278055001 0.230160803875943 0.0435682093877537 0.0498710938690317 0.102533463679303 0.196056391131315 0.0653242556453628 1.58557798664152 0.00102142651124778 0.00602046733796473 UP ENSG00000213988 ZNF90 zinc finger protein 90 [Source:HGNC Symbol;Acc:HGNC:13165] GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0003735|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0030529|GO:0006139|GO:0044249|GO:0019538|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0006518|GO:0046872|GO:0051252|GO:0005840|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0043043|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006412|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0008270|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 macromolecular complex|structural molecule activity|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|regulation of RNA metabolic process|ribosome|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|peptide biosynthetic process|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|translation|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|zinc ion binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 19:20077994-20127076 9 0 7 0 0 0 0.0957778241323807 0 0.0671600706785205 0 0 0 0.0543126316036337 0 Inf 0.00102850880865692 0.00605862312029277 UP ENSG00000183474 GTF2H2C GTF2H2 family member C [Source:HGNC Symbol;Acc:HGNC:31394] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006281|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0033554|GO:0043231|GO:0043169|GO:0000439|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0006259|GO:0010467|GO:0009059|GO:0006289|GO:0016070|GO:0005634|GO:0006974|GO:0032774|GO:2001141|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0008270 macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|DNA repair|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|core TFIIH complex|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|DNA metabolic process|gene expression|macromolecule biosynthetic process|nucleotide-excision repair|RNA metabolic process|nucleus|cellular response to DNA damage stimulus|RNA biosynthetic process|regulation of RNA biosynthetic process|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|zinc ion binding - - - - 5:69560208-69594723 36 43 49 99 100 78 0.252758390871636 0.274380587003261 0.310176121618695 0.622777170653546 0.576061889869093 0.513242956845224 0.279105033164531 0.570694005789288 -1.03190926884679 0.00103052519007621 0.00606930341774221 DOWN ENSG00000143669 LYST lysosomal trafficking regulator [Source:HGNC Symbol;Acc:HGNC:1968] GO:0040011|GO:0002376|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0001909|GO:0043229|GO:0006950|GO:0050900|GO:0006955|GO:0051641|GO:0048870|GO:0016043|GO:0051707|GO:0043473|GO:0009607|GO:0009605|GO:0042267|GO:0005622|GO:0005515|GO:0006935|GO:0045087|GO:0006810|GO:0001562|GO:0006952|GO:0098542|GO:0006928|GO:0009615|GO:0033059|GO:0009617|GO:0016477|GO:0051649|GO:0030595|GO:0051607|GO:0010256|GO:0002443|GO:0006996|GO:0016192|GO:0016050|GO:0033363|GO:0002228|GO:0046907|GO:0048753|GO:0060326|GO:0042742|GO:0042832|GO:0005856|GO:0007033|GO:0033364|GO:0032438|GO:0045022|GO:0016482|GO:0015630|GO:0016197|GO:0032509|GO:0032510|GO:0007040 locomotion|immune system process|cell|cellular process|response to stimulus|binding|cellular response to stimulus|leukocyte mediated cytotoxicity|intracellular organelle|response to stress|leukocyte migration|immune response|cellular localization|cell motility|cellular component organization|response to other organism|pigmentation|response to biotic stimulus|response to external stimulus|natural killer cell mediated cytotoxicity|intracellular|protein binding|chemotaxis|innate immune response|transport|response to protozoan|defense response|defense response to other organism|movement of cell or subcellular component|response to virus|cellular pigmentation|response to bacterium|cell migration|establishment of localization in cell|leukocyte chemotaxis|defense response to virus|endomembrane system organization|leukocyte mediated immunity|organelle organization|vesicle-mediated transport|vesicle organization|secretory granule organization|natural killer cell mediated immunity|intracellular transport|pigment granule organization|cell chemotaxis|defense response to bacterium|defense response to protozoan|cytoskeleton|vacuole organization|mast cell secretory granule organization|melanosome organization|early endosome to late endosome transport|cytosolic transport|microtubule cytoskeleton|endosomal transport|endosome transport via multivesicular body sorting pathway|endosome to lysosome transport via multivesicular body sorting pathway|lysosome organization - - - - 1:235661041-235883640 250 372 704 791 786 1247 0.673734603338465 0.911114645791283 1.71055371394669 1.90995715023572 1.73796074916232 3.14952340933875 1.09846765435881 2.26581376957893 -1.04453690032144 0.00103103909531853 0.00607113237704918 DOWN ENSG00000104427 ZC2HC1A zinc finger, C2HC-type containing 1A [Source:HGNC Symbol;Acc:HGNC:24277] GO:0005488|GO:0043167|GO:0005515|GO:0043169|GO:0046872 binding|ion binding|protein binding|cation binding|metal ion binding - - - - 8:78666047-78719765 1 7 9 18 27 16 0.0147923690264661 0.0940722280960193 0.119976817264539 0.238459704998114 0.327552192431086 0.221720936359593 0.0762804714623415 0.262577611262931 -1.78335824419525 0.00103175291450012 0.00607413754870568 DOWN ENSG00000266401 RP11-874J12.4 - - - - - - - 18:3653410-3656282 8 8 17 36 30 27 0.388913060883382 0.353469702152959 0.7451501785342 1.56814197638076 1.19666065291714 1.23019015494817 0.495844313856847 1.33166426141536 -1.42527127995562 0.00103475214997083 0.00608939299925667 DOWN ENSG00000268738 HSFX2 heat shock transcription factor family, X-linked 2 [Source:HGNC Symbol;Acc:HGNC:32701] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - X:149592515-149594716 18 12 13 4 4 6 0.932798823454849 0.565163095200611 0.607385569069895 0.185731436210505 0.170063492776222 0.291417574371216 0.701782495908452 0.215737501119314 1.70174698558262 0.00103586890921649 0.00609236217804357 UP ENSG00000184599 FAM19A3 family with sequence similarity 19 (chemokine (C-C motif)-like), member A3 [Source:HGNC Symbol;Acc:HGNC:21590] GO:0005576 extracellular region - - - - 1:112720419-112727235 8 12 25 3 2 7 0.386258364222062 0.526585409521388 1.08833988105186 0.129768258508178 0.0792275316175916 0.316771832351146 0.667061218265103 0.175255874158972 1.92835636731487 0.00103945135763994 0.0061086182738155 UP ENSG00000173567 ADGRF3 adhesion G protein-coupled receptor F3 [Source:HGNC Symbol;Acc:HGNC:18989] GO:0004871|GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0031224|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0007166|GO:0004930 signal transducer activity|signaling|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|intrinsic component of membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|G-protein coupled receptor activity - - - - 2:26308173-26346817 24 28 12 7 10 4 0.176620034509453 0.187270542885346 0.0796230362006411 0.0461541728195818 0.0603828329637736 0.0275845798492377 0.14783787119848 0.0447071952108644 1.72543694415786 0.00105177162619789 0.00617251624307288 UP ENSG00000196951 SCOC-AS1 SCOC antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:50601] - - - - - - 4:140283724-140373381 1 2 2 12 5 12 0.0256122668920065 0.0465344206145997 0.0461657994909254 0.275269718162149 0.105030725741547 0.287911495216438 0.0394374956658439 0.222737313040045 -2.49770341254081 0.00105280884256333 0.00617617512004044 DOWN ENSG00000072201 LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:6657] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0016043|GO:0016874|GO:0005622|GO:0005515|GO:0016740|GO:0022607|GO:0043169|GO:0005737|GO:0019904|GO:0019787|GO:0019538|GO:0046872|GO:0043412|GO:0030163|GO:0004842|GO:0030165|GO:0044265|GO:0036211|GO:0006508|GO:0006461|GO:0044267|GO:0044257|GO:0051259|GO:0051603|GO:0046914|GO:0006464|GO:0019941|GO:0051260|GO:0008270|GO:0032446|GO:0006511|GO:0042787|GO:0016567 cell|cellular process|metabolic process|binding|catalytic activity|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|cellular component organization|ligase activity|intracellular|protein binding|transferase activity|cellular component assembly|cation binding|cytoplasm|protein domain specific binding|ubiquitin-like protein transferase activity|protein metabolic process|metal ion binding|macromolecule modification|protein catabolic process|ubiquitin-protein transferase activity|PDZ domain binding|cellular macromolecule catabolic process|protein modification process|proteolysis|protein complex assembly|cellular protein metabolic process|cellular protein catabolic process|protein oligomerization|proteolysis involved in cellular protein catabolic process|transition metal ion binding|cellular protein modification process|modification-dependent protein catabolic process|protein homooligomerization|zinc ion binding|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination - - - - 4:53459301-53701405 18 25 62 90 72 127 0.146808531536477 0.185312230673885 0.455909803653726 0.657682967828777 0.481811440592234 0.970753766196959 0.262676855288029 0.70341605820599 -1.42108918164685 0.00106610208567186 0.00624679326116736 DOWN ENSG00000233885 YEATS2-AS1 YEATS2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:41101] - - - - - - 3:183806457-183810783 46 36 39 13 22 22 0.636392806085153 0.452638935037454 0.486467954956964 0.161141995850348 0.249729691905995 0.285252874743009 0.525166565359857 0.232041520833117 1.17839209012398 0.00107614590617497 0.00630193406884024 UP ENSG00000078687 TNRC6C trinucleotide repeat containing 6C [Source:HGNC Symbol;Acc:HGNC:29318] GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0009893|GO:0009058|GO:0005622|GO:0002682|GO:0005515|GO:0019222|GO:0045087|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0005737|GO:0009890|GO:0016458|GO:0006139|GO:0050776|GO:0007154|GO:0007165|GO:0000166|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0071774|GO:0032268|GO:0005829|GO:0010468|GO:0034645|GO:0006518|GO:0003723|GO:0007166|GO:0031047|GO:0010629|GO:0051252|GO:0044265|GO:0010628|GO:0032269|GO:0044344|GO:0070848|GO:0002764|GO:0043603|GO:0035556|GO:0044267|GO:0010467|GO:0071310|GO:0019439|GO:0051246|GO:0009059|GO:0016070|GO:0016441|GO:0006401|GO:0043043|GO:0008543|GO:0006396|GO:0050684|GO:0017148|GO:0071363|GO:0010608|GO:0002768|GO:0038179|GO:0006412|GO:0048017|GO:0040029|GO:0007167|GO:0016071|GO:0006417|GO:0007219|GO:0061014|GO:0035194|GO:0031442|GO:0048011|GO:0048015|GO:0006402|GO:0031440|GO:0006397|GO:0038093|GO:0035195|GO:1900153|GO:0007169|GO:0031123|GO:0000956|GO:0038095|GO:0035278|GO:0031124|GO:0038127|GO:0060213|GO:0007173|GO:0000289|GO:0000288 immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|positive regulation of metabolic process|biosynthetic process|intracellular|regulation of immune system process|protein binding|regulation of metabolic process|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cytoplasm|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|regulation of immune response|cell communication|signal transduction|nucleotide binding|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|regulation of cellular protein metabolic process|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|RNA binding|cell surface receptor signaling pathway|gene silencing by RNA|negative regulation of gene expression|regulation of RNA metabolic process|cellular macromolecule catabolic process|positive regulation of gene expression|negative regulation of cellular protein metabolic process|cellular response to fibroblast growth factor stimulus|response to growth factor|immune response-regulating signaling pathway|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|gene expression|cellular response to organic substance|aromatic compound catabolic process|regulation of protein metabolic process|macromolecule biosynthetic process|RNA metabolic process|posttranscriptional gene silencing|RNA catabolic process|peptide biosynthetic process|fibroblast growth factor receptor signaling pathway|RNA processing|regulation of mRNA processing|negative regulation of translation|cellular response to growth factor stimulus|posttranscriptional regulation of gene expression|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|translation|inositol lipid-mediated signaling|regulation of gene expression, epigenetic|enzyme linked receptor protein signaling pathway|mRNA metabolic process|regulation of translation|Notch signaling pathway|positive regulation of mRNA catabolic process|posttranscriptional gene silencing by RNA|positive regulation of mRNA 3'-end processing|neurotrophin TRK receptor signaling pathway|phosphatidylinositol-mediated signaling|mRNA catabolic process|regulation of mRNA 3'-end processing|mRNA processing|Fc receptor signaling pathway|gene silencing by miRNA|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|transmembrane receptor protein tyrosine kinase signaling pathway|RNA 3'-end processing|nuclear-transcribed mRNA catabolic process|Fc-epsilon receptor signaling pathway|miRNA mediated inhibition of translation|mRNA 3'-end processing|ERBB signaling pathway|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|epidermal growth factor receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay - - - - 17:78004168-78108835 17 31 33 54 74 64 0.0626434517916886 0.103820420353669 0.109639630220602 0.178289112541414 0.223735098878736 0.221027914053822 0.0920345007886532 0.207684041824657 -1.17414367773408 0.00108082218425815 0.00632683637036135 DOWN ENSG00000218890 NUFIP1P nuclear fragile X mental retardation protein interacting protein 1 pseudogene [Source:HGNC Symbol;Acc:HGNC:8058] - - - - - - 6:66093431-66094909 3 4 3 16 15 11 0.143498187504357 0.173866942742581 0.129344680063064 0.685618339078641 0.588640761103237 0.493045108793307 0.148903270103334 0.589101402991728 -1.98414055122944 0.00108684734405422 0.00635587475208516 DOWN ENSG00000185345 PARK2 parkin RBR E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:8607] GO:0032502|GO:0040007|GO:0032991|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0006950|GO:0016049|GO:0071704|GO:0009056|GO:0043167|GO:0051583|GO:0051051|GO:0044237|GO:0051641|GO:0006914|GO:0023051|GO:0009653|GO:0016043|GO:0045927|GO:0043227|GO:0044708|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0016874|GO:0050793|GO:0048589|GO:0005622|GO:0007269|GO:0005515|GO:0043234|GO:0012505|GO:0016740|GO:0007626|GO:0048856|GO:0019222|GO:0042802|GO:0016032|GO:0060341|GO:0044262|GO:0032182|GO:0050804|GO:0010506|GO:0008344|GO:0042391|GO:0045595|GO:0006725|GO:0051640|GO:0060760|GO:0008013|GO:0048468|GO:0030534|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0097413|GO:0051702|GO:0060627|GO:0050877|GO:0005102|GO:0034641|GO:0097602|GO:0030307|GO:0010636|GO:0044281|GO:0032940|GO:0061669|GO:0001964|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0050806|GO:0022607|GO:0010942|GO:0051098|GO:0045597|GO:0043231|GO:0090141|GO:0051087|GO:0043169|GO:0016234|GO:0019899|GO:0010243|GO:1903573|GO:0005737|GO:0032970|GO:0007267|GO:0032880|GO:0005975|GO:0042592|GO:0072593|GO:0051656|GO:0043005|GO:0010637|GO:0009966|GO:0045184|GO:0046883|GO:0019725|GO:0048639|GO:0006979|GO:0019904|GO:0060548|GO:0032231|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0044092|GO:0061024|GO:0007165|GO:0048588|GO:0000422|GO:0005783|GO:0009968|GO:0031647|GO:0048638|GO:0051649|GO:0046888|GO:0008092|GO:0048525|GO:0008219|GO:0001505|GO:0007611|GO:0016236|GO:0019787|GO:0050790|GO:0051048|GO:1903531|GO:0031072|GO:0030030|GO:0046929|GO:0050805|GO:0043086|GO:0010817|GO:0000151|GO:0048869|GO:0030029|GO:0010035|GO:0009967|GO:0044249|GO:0010876|GO:0019538|GO:0023014|GO:0050792|GO:0051589|GO:0010033|GO:0051224|GO:0001558|GO:0031324|GO:0031323|GO:0036503|GO:0005794|GO:0006996|GO:0051701|GO:0009636|GO:0046928|GO:0060560|GO:0098657|GO:0051017|GO:0061025|GO:0000165|GO:0016192|GO:0006836|GO:0019048|GO:1902533|GO:0051650|GO:0015631|GO:2001235|GO:0032268|GO:0030111|GO:0000902|GO:0006109|GO:0070050|GO:0005829|GO:0045732|GO:0031175|GO:1902882|GO:0051354|GO:0008053|GO:0071797|GO:0031344|GO:0050905|GO:0010468|GO:0034645|GO:0030178|GO:1901215|GO:0051582|GO:0019054|GO:1903008|GO:0051101|GO:0046872|GO:0007166|GO:0032956|GO:0090276|GO:0001959|GO:0000423|GO:0043412|GO:0072594|GO:0007010|GO:0050432|GO:0042417|GO:0034097|GO:0030163|GO:0007417|GO:0007612|GO:0010629|GO:0004842|GO:0015844|GO:0050821|GO:0010720|GO:0007005|GO:0043069|GO:0043130|GO:2001234|GO:0048878|GO:0051252|GO:0043274|GO:0009308|GO:0044793|GO:0017124|GO:0032386|GO:0050709|GO:1901216|GO:0003779|GO:0070997|GO:0051223|GO:0030165|GO:0015031|GO:0048489|GO:1903146|GO:0044265|GO:0031346|GO:0016235|GO:0071417|GO:0010628|GO:0010038|GO:0071869|GO:0010994|GO:0036211|GO:0032269|GO:0032232|GO:0001961|GO:2000377|GO:0070201|GO:0046907|GO:0042886|GO:0030544|GO:0006811|GO:1902235|GO:0016241|GO:0002020|GO:1902803|GO:0051046|GO:1900407|GO:0006986|GO:1904049|GO:0031098|GO:0050769|GO:0032368|GO:1990444|GO:1990234|GO:0071867|GO:0034599|GO:0097237|GO:0006869|GO:0009914|GO:0009306|GO:0005996|GO:0042826|GO:0051099|GO:0010992|GO:0051247|GO:0048471|GO:0006508|GO:0001664|GO:0022604|GO:0005739|GO:2000378|GO:1902236|GO:0006461|GO:0018958|GO:1901214|GO:0030036|GO:0051881|GO:0043269|GO:0034613|GO:0051341|GO:0019900|GO:0032270|GO:0012501|GO:0014070|GO:0006796|GO:0035556|GO:0060359|GO:0071241|GO:0002792|GO:0033043|GO:0044267|GO:0044390|GO:0051174|GO:0042176|GO:0010467|GO:0032990|GO:0019079|GO:0090140|GO:0007399|GO:0046903|GO:0019058|GO:0071310|GO:0050890|GO:1902532|GO:0031648|GO:0051648|GO:0031328|GO:0006626|GO:0051246|GO:0009059|GO:0030154|GO:0048858|GO:0043068|GO:0035967|GO:1903827|GO:1902531|GO:1903861|GO:0016070|GO:0010635|GO:0031667|GO:0006584|GO:0034976|GO:0001504|GO:0010557|GO:0005634|GO:1990452|GO:0010042|GO:0043067|GO:0051580|GO:1990138|GO:1903202|GO:0051960|GO:0015837|GO:0097190|GO:1903209|GO:0048284|GO:0044389|GO:0010638|GO:0048666|GO:0030182|GO:0050796|GO:0034620|GO:0031625|GO:0070059|GO:0090201|GO:0002790|GO:0016055|GO:0019318|GO:0044257|GO:0045893|GO:0097193|GO:0030073|GO:0006820|GO:0010975|GO:0000266|GO:0019221|GO:2001242|GO:0033365|GO:0033157|GO:1903382|GO:0031401|GO:1902176|GO:0008631|GO:0043122|GO:0090090|GO:0061630|GO:0034622|GO:0043065|GO:0071242|GO:0010498|GO:2001244|GO:0010803|GO:0043408|GO:0046676|GO:0060828|GO:0043523|GO:0032774|GO:1903364|GO:0006839|GO:0030162|GO:0006812|GO:2001141|GO:0015696|GO:2001243|GO:0008637|GO:0043623|GO:0045862|GO:0043525|GO:0050708|GO:0016310|GO:0015833|GO:0006605|GO:0072655|GO:0045069|GO:0043388|GO:0010822|GO:1902283|GO:0010823|GO:0071407|GO:0071287|GO:0016482|GO:0006886|GO:0010906|GO:0051494|GO:0051493|GO:0044828|GO:0051603|GO:0045071|GO:0043123|GO:1903223|GO:0097484|GO:0010821|GO:0007249|GO:0036475|GO:0001836|GO:1903265|GO:0042415|GO:0032872|GO:0042981|GO:0071345|GO:0044070|GO:0046914|GO:0050801|GO:0043066|GO:0043409|GO:0033673|GO:0051402|GO:0034612|GO:1902177|GO:1990381|GO:0043524|GO:0019901|GO:0070842|GO:0022008|GO:0031624|GO:0006464|GO:1903204|GO:0098779|GO:0007015|GO:0050767|GO:0048812|GO:1903214|GO:0051403|GO:0046879|GO:0010976|GO:1902175|GO:0042053|GO:0043549|GO:0071870|GO:0006351|GO:0006915|GO:0006355|GO:0071248|GO:0045666|GO:0009712|GO:1903533|GO:0051258|GO:0045944|GO:0006366|GO:0030072|GO:1903052|GO:0046328|GO:0006357|GO:1903377|GO:0019941|GO:0033132|GO:0006468|GO:0048699|GO:0071356|GO:1903506|GO:0006006|GO:1901800|GO:0060070|GO:0042325|GO:1903378|GO:0007254|GO:0001932|GO:1903351|GO:0042326|GO:0033209|GO:0014059|GO:1904264|GO:0001933|GO:0061572|GO:0015872|GO:0061136|GO:0008270|GO:0045664|GO:0015672|GO:0032873|GO:0043161|GO:0070585|GO:0007268|GO:0032446|GO:0006511|GO:0031398|GO:0007270|GO:0055065|GO:0031396|GO:0032434|GO:0032436|GO:0046329|GO:0001963|GO:0055069|GO:0042787|GO:1902916|GO:0035249|GO:0016567|GO:0051865|GO:0006513|GO:1902530|GO:0000209|GO:0070534|GO:0085020|GO:0070936|GO:0044314|GO:0097039|GO:0035519|GO:0070979 developmental process|growth|macromolecular complex|behavior|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|response to stress|cell growth|organic substance metabolic process|catabolic process|ion binding|dopamine uptake involved in synaptic transmission|negative regulation of transport|cellular metabolic process|cellular localization|autophagy|regulation of signaling|anatomical structure morphogenesis|cellular component organization|positive regulation of growth|membrane-bounded organelle|single-organism behavior|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|ligase activity|regulation of developmental process|developmental growth|intracellular|neurotransmitter secretion|protein binding|protein complex|endomembrane system|transferase activity|locomotory behavior|anatomical structure development|regulation of metabolic process|identical protein binding|viral process|regulation of cellular localization|cellular carbohydrate metabolic process|ubiquitin-like protein binding|modulation of synaptic transmission|regulation of autophagy|adult locomotory behavior|regulation of membrane potential|regulation of cell differentiation|cellular aromatic compound metabolic process|organelle localization|positive regulation of response to cytokine stimulus|beta-catenin binding|cell development|adult behavior|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|Lewy body|interaction with symbiont|regulation of vesicle-mediated transport|neurological system process|receptor binding|cellular nitrogen compound metabolic process|cullin family protein binding|positive regulation of cell growth|positive regulation of mitochondrial fusion|small molecule metabolic process|secretion by cell|spontaneous neurotransmitter secretion|startle response|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of synaptic transmission|cellular component assembly|positive regulation of cell death|regulation of binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|positive regulation of mitochondrial fission|chaperone binding|cation binding|inclusion body|enzyme binding|response to organonitrogen compound|negative regulation of response to endoplasmic reticulum stress|cytoplasm|regulation of actin filament-based process|cell-cell signaling|regulation of protein localization|carbohydrate metabolic process|homeostatic process|reactive oxygen species metabolic process|establishment of organelle localization|neuron projection|negative regulation of mitochondrial fusion|regulation of signal transduction|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|positive regulation of developmental growth|response to oxidative stress|protein domain specific binding|negative regulation of cell death|regulation of actin filament bundle assembly|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|negative regulation of molecular function|membrane organization|signal transduction|developmental cell growth|mitophagy|endoplasmic reticulum|negative regulation of signal transduction|regulation of protein stability|regulation of developmental growth|establishment of localization in cell|negative regulation of hormone secretion|cytoskeletal protein binding|negative regulation of viral process|cell death|regulation of neurotransmitter levels|learning or memory|macroautophagy|ubiquitin-like protein transferase activity|regulation of catalytic activity|negative regulation of secretion|negative regulation of secretion by cell|heat shock protein binding|cell projection organization|negative regulation of neurotransmitter secretion|negative regulation of synaptic transmission|negative regulation of catalytic activity|regulation of hormone levels|ubiquitin ligase complex|cellular developmental process|actin filament-based process|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|lipid localization|protein metabolic process|signal transduction by protein phosphorylation|regulation of viral process|negative regulation of neurotransmitter transport|response to organic substance|negative regulation of protein transport|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|ERAD pathway|Golgi apparatus|organelle organization|interaction with host|response to toxic substance|regulation of neurotransmitter secretion|developmental growth involved in morphogenesis|import into cell|actin filament bundle assembly|membrane fusion|MAPK cascade|vesicle-mediated transport|neurotransmitter transport|modulation by virus of host morphology or physiology|positive regulation of intracellular signal transduction|establishment of vesicle localization|tubulin binding|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|regulation of carbohydrate metabolic process|neuron cellular homeostasis|cytosol|positive regulation of protein catabolic process|neuron projection development|regulation of response to oxidative stress|negative regulation of oxidoreductase activity|mitochondrial fusion|LUBAC complex|regulation of cell projection organization|neuromuscular process|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|negative regulation of neuron death|positive regulation of neurotransmitter uptake|modulation by virus of host process|organelle disassembly|regulation of DNA binding|metal ion binding|cell surface receptor signaling pathway|regulation of actin cytoskeleton organization|regulation of peptide hormone secretion|regulation of cytokine-mediated signaling pathway|macromitophagy|macromolecule modification|establishment of protein localization to organelle|cytoskeleton organization|catecholamine secretion|dopamine metabolic process|response to cytokine|protein catabolic process|central nervous system development|learning|negative regulation of gene expression|ubiquitin-protein transferase activity|monoamine transport|protein stabilization|positive regulation of cell development|mitochondrion organization|negative regulation of programmed cell death|ubiquitin binding|negative regulation of apoptotic signaling pathway|chemical homeostasis|regulation of RNA metabolic process|phospholipase binding|amine metabolic process|negative regulation by host of viral process|SH3 domain binding|regulation of intracellular transport|negative regulation of protein secretion|positive regulation of neuron death|actin binding|neuron death|regulation of protein transport|PDZ domain binding|protein transport|synaptic vesicle transport|regulation of mitophagy|cellular macromolecule catabolic process|positive regulation of cell projection organization|aggresome|cellular response to organonitrogen compound|positive regulation of gene expression|response to metal ion|response to catecholamine|free ubiquitin chain polymerization|protein modification process|negative regulation of cellular protein metabolic process|negative regulation of actin filament bundle assembly|positive regulation of cytokine-mediated signaling pathway|regulation of reactive oxygen species metabolic process|regulation of establishment of protein localization|intracellular transport|amide transport|Hsp70 protein binding|ion transport|regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|regulation of macroautophagy|protease binding|regulation of synaptic vesicle transport|regulation of secretion|regulation of cellular response to oxidative stress|response to unfolded protein|negative regulation of spontaneous neurotransmitter secretion|stress-activated protein kinase signaling cascade|positive regulation of neurogenesis|regulation of lipid transport|F-box domain binding|transferase complex|response to monoamine|cellular response to oxidative stress|cellular response to toxic substance|lipid transport|hormone transport|protein secretion|monosaccharide metabolic process|histone deacetylase binding|positive regulation of binding|ubiquitin homeostasis|positive regulation of protein metabolic process|perinuclear region of cytoplasm|proteolysis|G-protein coupled receptor binding|regulation of cell morphogenesis|mitochondrion|negative regulation of reactive oxygen species metabolic process|negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway|protein complex assembly|phenol-containing compound metabolic process|regulation of neuron death|actin cytoskeleton organization|regulation of mitochondrial membrane potential|regulation of ion transport|cellular protein localization|regulation of oxidoreductase activity|kinase binding|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|response to ammonium ion|cellular response to inorganic substance|negative regulation of peptide secretion|regulation of organelle organization|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of phosphorus metabolic process|regulation of protein catabolic process|gene expression|cell part morphogenesis|viral genome replication|regulation of mitochondrial fission|nervous system development|secretion|viral life cycle|cellular response to organic substance|cognition|negative regulation of intracellular signal transduction|protein destabilization|vesicle localization|positive regulation of cellular biosynthetic process|protein targeting to mitochondrion|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|cellular response to topologically incorrect protein|regulation of cellular protein localization|regulation of intracellular signal transduction|positive regulation of dendrite extension|RNA metabolic process|regulation of mitochondrial fusion|response to nutrient levels|catecholamine metabolic process|response to endoplasmic reticulum stress|neurotransmitter uptake|positive regulation of macromolecule biosynthetic process|nucleus|Parkin-FBXW7-Cul1 ubiquitin ligase complex|response to manganese ion|regulation of programmed cell death|regulation of neurotransmitter uptake|neuron projection extension|negative regulation of oxidative stress-induced cell death|regulation of nervous system development|amine transport|apoptotic signaling pathway|positive regulation of oxidative stress-induced cell death|organelle fusion|ubiquitin-like protein ligase binding|positive regulation of organelle organization|neuron development|neuron differentiation|regulation of insulin secretion|cellular response to unfolded protein|ubiquitin protein ligase binding|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|negative regulation of release of cytochrome c from mitochondria|peptide secretion|Wnt signaling pathway|hexose metabolic process|cellular protein catabolic process|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|insulin secretion|anion transport|regulation of neuron projection development|mitochondrial fission|cytokine-mediated signaling pathway|regulation of intrinsic apoptotic signaling pathway|protein localization to organelle|regulation of intracellular protein transport|negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway|positive regulation of protein modification process|negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|intrinsic apoptotic signaling pathway in response to oxidative stress|regulation of I-kappaB kinase/NF-kappaB signaling|negative regulation of canonical Wnt signaling pathway|ubiquitin protein ligase activity|cellular macromolecular complex assembly|positive regulation of apoptotic process|cellular response to ammonium ion|proteasomal protein catabolic process|positive regulation of intrinsic apoptotic signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway|regulation of MAPK cascade|negative regulation of insulin secretion|regulation of canonical Wnt signaling pathway|regulation of neuron apoptotic process|RNA biosynthetic process|positive regulation of cellular protein catabolic process|mitochondrial transport|regulation of proteolysis|cation transport|regulation of RNA biosynthetic process|ammonium transport|negative regulation of intrinsic apoptotic signaling pathway|apoptotic mitochondrial changes|cellular protein complex assembly|positive regulation of proteolysis|positive regulation of neuron apoptotic process|regulation of protein secretion|phosphorylation|peptide transport|protein targeting|establishment of protein localization to mitochondrion|regulation of viral genome replication|positive regulation of DNA binding|positive regulation of mitochondrion organization|negative regulation of primary amine oxidase activity|negative regulation of mitochondrion organization|cellular response to organic cyclic compound|cellular response to manganese ion|cytosolic transport|intracellular protein transport|regulation of glucose metabolic process|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation by host of viral genome replication|proteolysis involved in cellular protein catabolic process|negative regulation of viral genome replication|positive regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of oxidative stress-induced neuron death|dendrite extension|regulation of mitochondrion organization|I-kappaB kinase/NF-kappaB signaling|neuron death in response to oxidative stress|release of cytochrome c from mitochondria|positive regulation of tumor necrosis factor-mediated signaling pathway|norepinephrine metabolic process|regulation of stress-activated MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|regulation of anion transport|transition metal ion binding|ion homeostasis|negative regulation of apoptotic process|negative regulation of MAPK cascade|negative regulation of kinase activity|neuron apoptotic process|response to tumor necrosis factor|positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|ubiquitin-specific protease binding|negative regulation of neuron apoptotic process|protein kinase binding|aggresome assembly|neurogenesis|ubiquitin conjugating enzyme binding|cellular protein modification process|negative regulation of oxidative stress-induced neuron death|mitophagy in response to mitochondrial depolarization|actin filament organization|regulation of neurogenesis|neuron projection morphogenesis|regulation of protein targeting to mitochondrion|stress-activated MAPK cascade|hormone secretion|positive regulation of neuron projection development|regulation of oxidative stress-induced intrinsic apoptotic signaling pathway|regulation of dopamine metabolic process|regulation of kinase activity|cellular response to catecholamine stimulus|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular response to metal ion|positive regulation of neuron differentiation|catechol-containing compound metabolic process|regulation of protein targeting|protein polymerization|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|peptide hormone secretion|positive regulation of proteolysis involved in cellular protein catabolic process|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|modification-dependent protein catabolic process|negative regulation of glucokinase activity|protein phosphorylation|generation of neurons|cellular response to tumor necrosis factor|regulation of nucleic acid-templated transcription|glucose metabolic process|positive regulation of proteasomal protein catabolic process|canonical Wnt signaling pathway|regulation of phosphorylation|positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway|JNK cascade|regulation of protein phosphorylation|cellular response to dopamine|negative regulation of phosphorylation|tumor necrosis factor-mediated signaling pathway|regulation of dopamine secretion|ubiquitin protein ligase activity involved in ERAD pathway|negative regulation of protein phosphorylation|actin filament bundle organization|dopamine transport|regulation of proteasomal protein catabolic process|zinc ion binding|regulation of neuron differentiation|monovalent inorganic cation transport|negative regulation of stress-activated MAPK cascade|proteasome-mediated ubiquitin-dependent protein catabolic process|protein localization to mitochondrion|synaptic transmission|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|neuron-neuron synaptic transmission|metal ion homeostasis|regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of JNK cascade|synaptic transmission, dopaminergic|zinc ion homeostasis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of protein polyubiquitination|synaptic transmission, glutamatergic|protein ubiquitination|protein autoubiquitination|protein monoubiquitination|positive regulation of protein linear polyubiquitination|protein polyubiquitination|protein K63-linked ubiquitination|protein K6-linked ubiquitination|protein K48-linked ubiquitination|protein K27-linked ubiquitination|protein linear polyubiquitination|protein K29-linked ubiquitination|protein K11-linked ubiquitination K04556 parkin[2.3.2.27] hsa04141|hsa05012|hsa04120 Protein processing in endoplasmic reticulum - Homo sapiens (human)|Parkinson,s disease - Homo sapiens (human)|Ubiquitin mediated proteolysis - Homo sapiens (human) 6:161347420-162727771 0 0 0 2 7 4 0 0 0 0.0175061048492845 0.0561066467399071 0.0366169011891828 0 0.0367432175927915 -Inf 0.00108728563998104 0.006357192615745 DOWN ENSG00000187172 BAGE2 B melanoma antigen family member 2 [Source:HGNC Symbol;Acc:HGNC:15723] - - - - - - 21:10413477-10516431 1 0 0 9 4 4 0.0139277097859897 0 0 0.112260502726922 0.0456872008737538 0.0521832280084378 0.00464256992866323 0.0700436438697045 -3.91525859280919 0.00109000460539384 0.00637059465337271 DOWN ENSG00000274737 RP5-1057I20.6 - - - - - - - 12:47817451-47817966 0 0 0 3 4 4 0 0 0 0.368431199059073 0.449877262867332 0.513842987424171 0 0.444050483116859 -Inf 0.00109516090928347 0.0063982257897747 DOWN ENSG00000278153 RP4-585I14.3 - - - - - - - 20:13368291-13368703 0 0 0 4 4 3 0 0 0 0.613858136627939 0.562074255785819 0.481494518482214 0 0.552475636965324 -Inf 0.00109697160237804 0.00640629699088301 DOWN ENSG00000278932 bP-21264C1.2 - - - - - - - 21:9325013-9368775 1 1 2 13 8 5 0.0256030005146939 0.0232697998324672 0.0461490969585481 0.29808937220797 0.167992567520991 0.119934603342617 0.0316739657685697 0.195338847690526 -2.62460947357771 0.00109790679127361 0.00641050446835172 DOWN ENSG00000253771 TPTE2P1 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:35196] - - - - - - 13:24924677-24968487 0 2 0 6 6 7 0 0.0572205625981927 0 0.169241261967516 0.154964397623193 0.206529031773221 0.0190735208660642 0.176911563787977 -3.21338526573341 0.00109882138871608 0.00641333601930203 DOWN ENSG00000281991 TMEM265 transmembrane protein 265 [Source:HGNC Symbol;Acc:HGNC:51241] GO:0016020|GO:0050896|GO:0009607|GO:0031224|GO:0016021 membrane|response to stimulus|response to biotic stimulus|intrinsic component of membrane|integral component of membrane - - - - 16:30740381-30744281 40 123 18 24 4 13 2.8436935073612 7.94710410088785 1.15377380496567 1.52871994407235 0.23330318355733 0.866186656694612 3.98152380440491 0.876069928108097 2.18420274731799 0.00109865862526792 0.00641333601930203 UP ENSG00000177943 MAMDC4 MAM domain containing 4 [Source:HGNC Symbol;Acc:HGNC:24083] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0006810|GO:0045184|GO:0008104|GO:0016021|GO:0015031 membrane|binding|intrinsic component of membrane|protein binding|transport|establishment of protein localization|protein localization|integral component of membrane|protein transport - - - - 9:136850943-136860799 20 22 31 56 52 64 0.184812216840261 0.184757759077665 0.258273839023024 0.463644612613802 0.394253320014343 0.554258894601851 0.209281271646983 0.470718942409999 -1.16942269816472 0.00110739401547441 0.00645778797518034 DOWN ENSG00000226051 ZNF503-AS1 ZNF503 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:27370] - - - - - - 10:75269819-75373500 6 3 3 17 14 16 0.0850674238703128 0.038663525936075 0.0383445142941013 0.215963606977384 0.16286559592851 0.212610334645078 0.054025154700163 0.197146512516991 -1.86756498634268 0.00111405599949505 0.00649209990414313 DOWN ENSG00000230939 RP11-314C16.1 - - - - - - - 6:8784178-8785445 0 0 0 4 3 4 0 0 0 0.518452782059998 0.356097262585121 0.542214686116303 0 0.472254910253807 -Inf 0.00112321828104014 0.00654038591031251 DOWN ENSG00000198466 ZNF587 zinc finger protein 587 [Source:HGNC Symbol;Acc:HGNC:30955] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57849857-57865112 233 302 586 601 1107 669 1.06512098796916 1.25467010649341 2.41520855918108 2.4615857563242 4.15201428541017 2.86614543627861 1.57833321788122 3.15991515933766 -1.00148400451538 0.00112454720410518 0.0065468471590008 DOWN ENSG00000249855 EEF1A1P19 eukaryotic translation elongation factor 1 alpha 1 pseudogene 19 [Source:HGNC Symbol;Acc:HGNC:37892] - - - - - - 5:43495073-43496454 26 35 46 17 21 11 1.33078067843791 1.62813748004725 2.12281016171858 0.779625495810541 0.881913666520262 0.527651024533503 1.69390944006791 0.729730062288102 1.21492195323441 0.00114536776441067 0.00665508159570184 UP ENSG00000254632 RP11-21L23.4 - - - - - - - 11:76759916-76768223 35 29 27 61 74 81 4.60181058477532 3.4653572210983 3.20069522255464 7.18600690239183 7.98293486631267 9.98113483847432 3.75595434280942 8.38335886905961 -1.1583488628849 0.00115032182495284 0.00668256621174201 DOWN ENSG00000280233 RP11-159D12.3 - - - - - - - 17:57988180-57988760 3 4 3 11 14 17 0.365290566814017 0.442597604675177 0.329261242363634 1.19992653970595 1.39851369722433 1.93975680709468 0.379049804617609 1.51273234800832 -1.99669742356504 0.0011535105398795 0.00669978670380594 DOWN ENSG00000196611 MMP1 matrix metallopeptidase 1 [Source:HGNC Symbol;Acc:HGNC:7155] GO:0040011|GO:0031012|GO:0002376|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0050794|GO:0005578|GO:0006950|GO:0044089|GO:0071704|GO:0050900|GO:0009056|GO:0043167|GO:0044237|GO:0048870|GO:0016043|GO:0016787|GO:0016032|GO:0050817|GO:0051130|GO:0043062|GO:0051128|GO:0022607|GO:0043169|GO:0008233|GO:0009611|GO:0006928|GO:0044236|GO:0016477|GO:0019538|GO:0031334|GO:0043254|GO:0050878|GO:0030574|GO:0044259|GO:0046872|GO:0022617|GO:0007596|GO:0032461|GO:0042060|GO:0032459|GO:0007599|GO:0006508|GO:0006461|GO:0044267|GO:0030198|GO:0008237|GO:0051259|GO:0005509|GO:0004175|GO:0046914|GO:0032963|GO:0008270|GO:0004222 locomotion|extracellular matrix|immune system process|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|regulation of cellular process|proteinaceous extracellular matrix|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|leukocyte migration|catabolic process|ion binding|cellular metabolic process|cell motility|cellular component organization|hydrolase activity|viral process|coagulation|positive regulation of cellular component organization|extracellular structure organization|regulation of cellular component organization|cellular component assembly|cation binding|peptidase activity|response to wounding|movement of cell or subcellular component|multicellular organism metabolic process|cell migration|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|regulation of body fluid levels|collagen catabolic process|multicellular organismal macromolecule metabolic process|metal ion binding|extracellular matrix disassembly|blood coagulation|positive regulation of protein oligomerization|wound healing|regulation of protein oligomerization|hemostasis|proteolysis|protein complex assembly|cellular protein metabolic process|extracellular matrix organization|metallopeptidase activity|protein oligomerization|calcium ion binding|endopeptidase activity|transition metal ion binding|collagen metabolic process|zinc ion binding|metalloendopeptidase activity K01388 matrix metalloproteinase-1 (interstitial collagenase)[3.4.24.7] hsa05200|hsa05323|hsa03320|hsa05219 Pathways in cancer - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Bladder cancer - Homo sapiens (human) 11:102789920-102798160 6 12 10 1 4 2 0.215432171415731 0.391597779161845 0.323746456836109 0.0321567479699553 0.117835871898245 0.0672951729723026 0.310258802471228 0.0724292642801676 2.09882751626603 0.00115665878420627 0.00671545922670052 UP ENSG00000216937 CCDC7 coiled-coil domain containing 7 [Source:HGNC Symbol;Acc:HGNC:26533] - - - - - - 10:32446140-32574564 9 7 7 25 31 18 0.0895030503314965 0.0632702852820689 0.0627601560241987 0.222759631107106 0.252945940893968 0.167761064290697 0.071844497212588 0.214488878763924 -1.57795328036016 0.00116009994583412 0.00673281955344709 DOWN ENSG00000260493 RP11-219B4.7 - - - - - - - 8:85172077-85177062 0 0 0 8 2 3 0 0 0 0.289575568734824 0.066286883963319 0.113567810470105 0 0.156476754389416 -Inf 0.00116252948350628 0.00674429755161219 DOWN ENSG00000243587 C6orf183 chromosome 6 open reading frame 183 [Source:HGNC Symbol;Acc:HGNC:21562] - - - - - - 6:109165833-109271014 15 14 16 33 40 44 0.239782276767667 0.203394854035474 0.23060990552484 0.472649030216379 0.524642043037793 0.659192176355165 0.224595678775994 0.552161083203112 -1.29775903856599 0.0011707642754827 0.00678547790337032 DOWN ENSG00000118194 TNNT2 troponin T type 2 (cardiac) [Source:HGNC Symbol;Acc:HGNC:11949] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0060090|GO:0009892|GO:0050794|GO:0043229|GO:0051641|GO:0009653|GO:0016043|GO:0009893|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0030017|GO:0007507|GO:0060341|GO:0009888|GO:0006810|GO:0007275|GO:0048513|GO:0032972|GO:0016817|GO:0022607|GO:0061061|GO:0005737|GO:0032970|GO:0003012|GO:0006928|GO:0009887|GO:0048729|GO:0030674|GO:0043085|GO:0044092|GO:0051270|GO:0051649|GO:0008092|GO:0050790|GO:0043086|GO:0030029|GO:0005861|GO:0010035|GO:0003013|GO:0006996|GO:0003205|GO:0005829|GO:0006936|GO:0005865|GO:0003208|GO:0007010|GO:0072358|GO:0051345|GO:0005523|GO:0030048|GO:0032386|GO:0048738|GO:0003779|GO:0003007|GO:0031013|GO:0090257|GO:0010038|GO:0016818|GO:0060537|GO:0046907|GO:0043292|GO:0003231|GO:0030172|GO:0051346|GO:0006461|GO:0030036|GO:0060415|GO:0007517|GO:0072359|GO:0008015|GO:0005856|GO:0048644|GO:0006941|GO:0008016|GO:0032781|GO:0015629|GO:0070252|GO:0030016|GO:0032780|GO:0051259|GO:0006937|GO:0060047|GO:0051592|GO:0030049|GO:0032971|GO:0003229|GO:0055008|GO:0014706|GO:0055010|GO:0007015|GO:0016462|GO:0043462|GO:0051764|GO:0033275|GO:0051291|GO:0017111|GO:0060048|GO:0016887 developmental process|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|binding, bridging|negative regulation of metabolic process|regulation of cellular process|intracellular organelle|cellular localization|anatomical structure morphogenesis|cellular component organization|positive regulation of metabolic process|hydrolase activity|intracellular|protein binding|protein complex|anatomical structure development|regulation of metabolic process|sarcomere|heart development|regulation of cellular localization|tissue development|transport|multicellular organism development|animal organ development|regulation of muscle filament sliding speed|hydrolase activity, acting on acid anhydrides|cellular component assembly|muscle structure development|cytoplasm|regulation of actin filament-based process|muscle system process|movement of cell or subcellular component|organ morphogenesis|tissue morphogenesis|protein binding, bridging|positive regulation of catalytic activity|negative regulation of molecular function|regulation of cellular component movement|establishment of localization in cell|cytoskeletal protein binding|regulation of catalytic activity|negative regulation of catalytic activity|actin filament-based process|troponin complex|response to inorganic substance|circulatory system process|organelle organization|cardiac chamber development|cytosol|muscle contraction|striated muscle thin filament|cardiac ventricle morphogenesis|cytoskeleton organization|cardiovascular system development|positive regulation of hydrolase activity|tropomyosin binding|actin filament-based movement|regulation of intracellular transport|cardiac muscle tissue development|actin binding|heart morphogenesis|troponin I binding|regulation of muscle system process|response to metal ion|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|muscle tissue development|intracellular transport|contractile fiber|cardiac ventricle development|troponin C binding|negative regulation of hydrolase activity|protein complex assembly|actin cytoskeleton organization|muscle tissue morphogenesis|muscle organ development|circulatory system development|blood circulation|cytoskeleton|muscle organ morphogenesis|striated muscle contraction|regulation of heart contraction|positive regulation of ATPase activity|actin cytoskeleton|actin-mediated cell contraction|myofibril|negative regulation of ATPase activity|protein oligomerization|regulation of muscle contraction|heart contraction|response to calcium ion|muscle filament sliding|regulation of muscle filament sliding|ventricular cardiac muscle tissue development|cardiac muscle tissue morphogenesis|striated muscle tissue development|ventricular cardiac muscle tissue morphogenesis|actin filament organization|pyrophosphatase activity|regulation of ATPase activity|actin crosslink formation|actin-myosin filament sliding|protein heterooligomerization|nucleoside-triphosphatase activity|cardiac muscle contraction|ATPase activity K12045 troponin T, cardiac muscle[-] hsa04261|hsa05414|hsa05410|hsa04260 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human) 1:201359008-201377762 17 10 55 7 4 10 0.0968199436870576 0.0517611127850801 0.28242292570762 0.0357193163560242 0.0186905529500437 0.0533758430376476 0.143667994059919 0.0359285707812385 1.99953524618286 0.0011766317904472 0.00681551522545805 UP ENSG00000270066 SCARNA2 small Cajal body-specific RNA 2 [Source:EntrezGene;Acc:677766] - - - - - - 1:109100193-109100619 3 3 5 0 0 0 0.497034705664974 0.451738479847959 0.746737437486414 0 0 0 0.565170207666449 0 Inf 0.00117762708316366 0.00681995711751075 UP ENSG00000226312 CFLAR-AS1 CFLAR antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:14437] - - - - - - 2:201140278-201157823 17 10 16 3 8 2 0.141421110266171 0.0756054358215565 0.120010447130121 0.0223580499487806 0.0546079567950159 0.015591143214799 0.112345664405949 0.0308523833195318 1.86449060402721 0.00118975708516036 0.00688219492741276 UP ENSG00000277072 STAG3L2 stromal antigen 3-like 2 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:33886] - - - - - - 7:74882163-74890610 22 40 33 69 75 72 0.39298097116377 0.649366687667368 0.531475338816838 1.10432286220744 1.09921267314661 1.20533782858559 0.524607665882659 1.13629112131321 -1.11502171075169 0.00119019684016992 0.0068834049721877 DOWN ENSG00000204442 FAM155A family with sequence similarity 155 member A [Source:HGNC Symbol;Acc:HGNC:33877] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 13:107163510-107866735 0 0 0 3 5 3 0 0 0 0.0223580499487806 0.0341291185727268 0.0233867148221986 0 0.0266246277812353 -Inf 0.00119128257394489 0.00688834978937645 DOWN ENSG00000205693 MANSC4 MANSC domain containing 4 [Source:HGNC Symbol;Acc:HGNC:40023] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 12:27762738-27771276 25 26 27 61 62 56 1.72867885154201 1.63389037542112 1.68325907109912 3.77915123507996 3.51744949541413 3.62902772082603 1.68194276602075 3.64187615044004 -1.11455324761986 0.00119767014292607 0.0069199234462773 DOWN ENSG00000214881 TMEM14DP transmembrane protein 14D, pseudogene [Source:HGNC Symbol;Acc:HGNC:15660] - - - - - - 10:68544489-68544833 10 12 10 41 35 20 2.05024820139609 2.23608007231546 1.84863918831054 7.53193849148451 5.88794534845895 3.84306069871062 2.04498915400736 5.75431484621803 -1.4925509684383 0.00119807925375641 0.00692094776347601 DOWN ENSG00000254331 CKS1BP7 CDC28 protein kinase regulatory subunit 1B pseudogene 7 [Source:HGNC Symbol;Acc:HGNC:1999] - - - - - - 8:80644939-80645173 166 151 102 82 89 46 49.9672405829216 41.308140589776 27.6815364195896 22.1150534430822 21.9805048670124 12.9765824303278 39.6523058640957 19.0240469134741 1.05958058618754 0.00119883661330383 0.00692398302448685 UP ENSG00000227295 ELL2P1 elongation factor, RNA polymerase II, 2 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:39343] - - - - - - 1:158175850-158177755 3 5 15 30 21 24 0.111350377397137 0.168660511570418 0.50190839757284 0.997566348369882 0.639456813814796 0.834768855884806 0.260639762180132 0.823930672689828 -1.66046575843741 0.00119907725948249 0.00692403336645849 DOWN ENSG00000178199 ZC3H12D zinc finger CCCH-type containing 12D [Source:HGNC Symbol;Acc:HGNC:21175] GO:0040007|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0016049|GO:0071704|GO:0043167|GO:0044237|GO:0045926|GO:0016043|GO:0043227|GO:0040008|GO:0016787|GO:0005622|GO:0051726|GO:0007049|GO:0006725|GO:0022402|GO:1901360|GO:0034641|GO:0016788|GO:0046483|GO:0051128|GO:0045786|GO:0043231|GO:0043169|GO:0030308|GO:0005737|GO:0030529|GO:0006139|GO:0001558|GO:0035770|GO:0046872|GO:1903047|GO:0044770|GO:0000278|GO:0004518|GO:0007346|GO:0010564|GO:0045930|GO:0005634|GO:0036464|GO:0010948|GO:0044772|GO:1901990|GO:0004519|GO:1901987|GO:0090305|GO:0000932|GO:1901991|GO:2000045|GO:1902806|GO:2000134|GO:0000082|GO:1902807 growth|macromolecular complex|cell|cellular process|metabolic process|binding|catalytic activity|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|cell growth|organic substance metabolic process|ion binding|cellular metabolic process|negative regulation of growth|cellular component organization|membrane-bounded organelle|regulation of growth|hydrolase activity|intracellular|regulation of cell cycle|cell cycle|cellular aromatic compound metabolic process|cell cycle process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|heterocycle metabolic process|regulation of cellular component organization|negative regulation of cell cycle|intracellular membrane-bounded organelle|cation binding|negative regulation of cell growth|cytoplasm|intracellular ribonucleoprotein complex|nucleobase-containing compound metabolic process|regulation of cell growth|ribonucleoprotein granule|metal ion binding|mitotic cell cycle process|cell cycle phase transition|mitotic cell cycle|nuclease activity|regulation of mitotic cell cycle|regulation of cell cycle process|negative regulation of mitotic cell cycle|nucleus|cytoplasmic ribonucleoprotein granule|negative regulation of cell cycle process|mitotic cell cycle phase transition|regulation of mitotic cell cycle phase transition|endonuclease activity|regulation of cell cycle phase transition|nucleic acid phosphodiester bond hydrolysis|cytoplasmic mRNA processing body|negative regulation of mitotic cell cycle phase transition|regulation of G1/S transition of mitotic cell cycle|regulation of cell cycle G1/S phase transition|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|negative regulation of cell cycle G1/S phase transition - - - - 6:149446795-149485061 8 10 5 1 2 1 0.0657833647506766 0.0747352965346076 0.0370677616608578 0.00736442612192653 0.0134931799371974 0.0077058527525829 0.0591954743153807 0.00952115293723561 2.63627869306675 0.00121322927422959 0.00700439890791921 UP ENSG00000273295 AP000350.5 - - - - - - - 22:23901432-23907068 48 84 75 118 150 186 0.602331655740592 0.957980020337385 0.84854599560456 1.32671352399473 1.54438642007667 2.1874578692149 0.802952557227512 1.6861859377621 -1.07037697961773 0.00122052792473879 0.00704517414252741 DOWN ENSG00000064393 HIPK2 homeodomain interacting protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:14402] GO:0032502|GO:0032991|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0046790|GO:0048523|GO:0008283|GO:0050794|GO:0031128|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0023051|GO:0000989|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0002262|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0043234|GO:0016740|GO:0007626|GO:0048856|GO:0048646|GO:0019222|GO:0016032|GO:0048514|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0008344|GO:0003712|GO:0006725|GO:0060041|GO:0009888|GO:0030534|GO:1901360|GO:0001568|GO:0010941|GO:0002088|GO:0007275|GO:0048513|GO:0034101|GO:0034641|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0033554|GO:0090287|GO:0051098|GO:0043231|GO:0046332|GO:0002089|GO:0005737|GO:0007389|GO:0001076|GO:0007423|GO:0071559|GO:0009887|GO:0005667|GO:0042592|GO:0003407|GO:0009966|GO:0048729|GO:0048598|GO:0048568|GO:0009890|GO:0060548|GO:0010646|GO:0090288|GO:0006139|GO:0001525|GO:0060235|GO:0007154|GO:0007165|GO:0009968|GO:0008134|GO:0008219|GO:0010842|GO:0001666|GO:0000166|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0061072|GO:0010033|GO:0031324|GO:0031323|GO:0006996|GO:0051090|GO:0051701|GO:0003713|GO:0000165|GO:0019048|GO:1902533|GO:0032268|GO:0010468|GO:0071773|GO:0034645|GO:1901215|GO:0030218|GO:0003714|GO:0051101|GO:0090101|GO:0007166|GO:0001654|GO:0060059|GO:0035639|GO:0044798|GO:0001944|GO:0043412|GO:0030514|GO:0030097|GO:0072358|GO:0001104|GO:0001085|GO:0010629|GO:0043069|GO:0051252|GO:0001883|GO:0070997|GO:0009790|GO:0010628|GO:0007628|GO:0036211|GO:0071560|GO:0071456|GO:0048872|GO:0032549|GO:0051091|GO:0045766|GO:0003002|GO:0031981|GO:0031098|GO:0045765|GO:0060042|GO:0051099|GO:0051247|GO:0070848|GO:0005654|GO:0016301|GO:1901214|GO:0030511|GO:0071453|GO:0032270|GO:0012501|GO:0006796|GO:1901342|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0048562|GO:0007399|GO:0071310|GO:0060395|GO:0017076|GO:0006997|GO:0031328|GO:0030510|GO:0051246|GO:0009059|GO:0030154|GO:0001191|GO:1902531|GO:0016070|GO:0072359|GO:0016773|GO:0033613|GO:0050881|GO:0010557|GO:0005634|GO:0043067|GO:0006974|GO:0097190|GO:0043393|GO:0031076|GO:0030182|GO:0070304|GO:0045893|GO:0097193|GO:0001102|GO:0031401|GO:0043408|GO:0045892|GO:0043010|GO:0043523|GO:0072331|GO:0042770|GO:0032774|GO:0005524|GO:0050882|GO:2001141|GO:0007224|GO:0071363|GO:0030554|GO:0016310|GO:1902679|GO:0043388|GO:0007179|GO:0048048|GO:0016604|GO:0030509|GO:0007167|GO:0001105|GO:0008630|GO:0032092|GO:0043410|GO:0032872|GO:0042981|GO:0009952|GO:0043066|GO:0004672|GO:0051402|GO:0090575|GO:0030099|GO:0043524|GO:0022008|GO:0006464|GO:0048596|GO:0051403|GO:0017015|GO:0006351|GO:0006915|GO:0006355|GO:0048592|GO:0036294|GO:0045944|GO:0006366|GO:0072332|GO:1903507|GO:0046328|GO:0006357|GO:0048593|GO:0006468|GO:0048699|GO:0042771|GO:1903506|GO:0001190|GO:0042325|GO:0007254|GO:0001932|GO:0018193|GO:0016605|GO:0004674|GO:0030578|GO:0032874|GO:0001934|GO:0007178|GO:0000122|GO:0042772|GO:0042327|GO:0030330|GO:0046330|GO:0018105|GO:0018107|GO:0006978 developmental process|macromolecular complex|immune system process|behavior|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|virion binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|developmental induction|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|myeloid cell homeostasis|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|protein complex|transferase activity|locomotory behavior|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|viral process|blood vessel morphogenesis|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|adult locomotory behavior|transcription cofactor activity|cellular aromatic compound metabolic process|retina development in camera-type eye|tissue development|adult behavior|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|lens development in camera-type eye|multicellular organism development|animal organ development|erythrocyte homeostasis|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|regulation of cellular response to growth factor stimulus|regulation of binding|intracellular membrane-bounded organelle|SMAD binding|lens morphogenesis in camera-type eye|cytoplasm|pattern specification process|transcription factor activity, RNA polymerase II transcription factor binding|sensory organ development|response to transforming growth factor beta|organ morphogenesis|transcription factor complex|homeostatic process|neural retina development|regulation of signal transduction|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|negative regulation of cell death|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|nucleobase-containing compound metabolic process|angiogenesis|lens induction in camera-type eye|cell communication|signal transduction|negative regulation of signal transduction|transcription factor binding|cell death|retina layer formation|response to hypoxia|nucleotide binding|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|iris morphogenesis|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|regulation of sequence-specific DNA binding transcription factor activity|interaction with host|transcription coactivator activity|MAPK cascade|modulation by virus of host morphology or physiology|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|negative regulation of neuron death|erythrocyte differentiation|transcription corepressor activity|regulation of DNA binding|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|cell surface receptor signaling pathway|eye development|embryonic retina morphogenesis in camera-type eye|purine ribonucleoside triphosphate binding|nuclear transcription factor complex|vasculature development|macromolecule modification|negative regulation of BMP signaling pathway|hemopoiesis|cardiovascular system development|RNA polymerase II transcription cofactor activity|RNA polymerase II transcription factor binding|negative regulation of gene expression|negative regulation of programmed cell death|regulation of RNA metabolic process|purine nucleoside binding|neuron death|embryo development|positive regulation of gene expression|adult walking behavior|protein modification process|cellular response to transforming growth factor beta stimulus|cellular response to hypoxia|homeostasis of number of cells|ribonucleoside binding|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of angiogenesis|regionalization|nuclear lumen|stress-activated protein kinase signaling cascade|regulation of angiogenesis|retina morphogenesis in camera-type eye|positive regulation of binding|positive regulation of protein metabolic process|response to growth factor|nucleoplasm|kinase activity|regulation of neuron death|positive regulation of transforming growth factor beta receptor signaling pathway|cellular response to oxygen levels|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|regulation of vasculature development|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|embryonic organ morphogenesis|nervous system development|cellular response to organic substance|SMAD protein signal transduction|purine nucleotide binding|nucleus organization|positive regulation of cellular biosynthetic process|regulation of BMP signaling pathway|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|transcriptional repressor activity, RNA polymerase II transcription factor binding|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|phosphotransferase activity, alcohol group as acceptor|activating transcription factor binding|musculoskeletal movement|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|regulation of protein binding|embryonic camera-type eye development|neuron differentiation|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|RNA polymerase II activating transcription factor binding|positive regulation of protein modification process|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|camera-type eye development|regulation of neuron apoptotic process|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|ATP binding|voluntary musculoskeletal movement|regulation of RNA biosynthetic process|smoothened signaling pathway|cellular response to growth factor stimulus|adenyl nucleotide binding|phosphorylation|negative regulation of RNA biosynthetic process|positive regulation of DNA binding|transforming growth factor beta receptor signaling pathway|embryonic eye morphogenesis|nuclear body|BMP signaling pathway|enzyme linked receptor protein signaling pathway|RNA polymerase II transcription coactivator activity|intrinsic apoptotic signaling pathway in response to DNA damage|positive regulation of protein binding|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|anterior/posterior pattern specification|negative regulation of apoptotic process|protein kinase activity|neuron apoptotic process|RNA polymerase II transcription factor complex|myeloid cell differentiation|negative regulation of neuron apoptotic process|neurogenesis|cellular protein modification process|embryonic camera-type eye morphogenesis|stress-activated MAPK cascade|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|eye morphogenesis|cellular response to decreased oxygen levels|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of nucleic acid-templated transcription|regulation of JNK cascade|regulation of transcription from RNA polymerase II promoter|camera-type eye morphogenesis|protein phosphorylation|generation of neurons|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of nucleic acid-templated transcription|transcriptional activator activity, RNA polymerase II transcription factor binding|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|peptidyl-amino acid modification|PML body|protein serine/threonine kinase activity|PML body organization|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|DNA damage response, signal transduction resulting in transcription|positive regulation of phosphorylation|DNA damage response, signal transduction by p53 class mediator|positive regulation of JNK cascade|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator - - - - 7:139561570-139777778 226 322 128 383 565 727 0.892901815053797 1.15619477599756 0.455953441159412 1.35579005086948 1.83152044101985 2.69190132540972 0.83501667740359 1.95973727243302 -1.23078333851656 0.00123970282007161 0.00714618420359485 DOWN ENSG00000263990 CTC-542B22.2 - - - - - - - 17:31873926-31886666 7 6 12 2 1 2 1.01468867031066 0.790417648513149 1.56831275401755 0.259757592650962 0.118982023738427 0.271662890892287 1.12447302428045 0.216800835760559 2.37480682841484 0.00124335594233134 0.00716447564222346 UP ENSG00000277959 RP11-45A17.2 - - - - - - - 10:131971202-131971533 19 16 8 4 5 4 4.04810489906501 3.09818323272624 1.53682053004129 0.763624730202828 0.874096069951493 0.79862343828576 2.89436955394418 0.812114746146694 1.83349364768414 0.00124421479867018 0.00716804102653406 UP ENSG00000127920 GNG11 guanine nucleotide binding protein (G protein), gamma 11 [Source:HGNC Symbol;Acc:HGNC:4403] GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0019898|GO:0050794|GO:0044237|GO:0071944|GO:0016787|GO:0005622|GO:0005886|GO:0043234|GO:0009898|GO:0098797|GO:0015980|GO:0044281|GO:0016817|GO:0010243|GO:0031234|GO:0098562|GO:0019897|GO:0007154|GO:0007165|GO:0009725|GO:0005834|GO:0006091|GO:0010033|GO:0055114|GO:0007186|GO:1901652|GO:0071417|GO:0016818|GO:0043434|GO:0006112|GO:0071310|GO:0032870|GO:1901653|GO:0071375|GO:0033762|GO:0016462|GO:0071377|GO:0017111|GO:0003924 macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|extrinsic component of membrane|regulation of cellular process|cellular metabolic process|cell periphery|hydrolase activity|intracellular|plasma membrane|protein complex|cytoplasmic side of plasma membrane|plasma membrane protein complex|energy derivation by oxidation of organic compounds|small molecule metabolic process|hydrolase activity, acting on acid anhydrides|response to organonitrogen compound|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|extrinsic component of plasma membrane|cell communication|signal transduction|response to hormone|heterotrimeric G-protein complex|generation of precursor metabolites and energy|response to organic substance|oxidation-reduction process|G-protein coupled receptor signaling pathway|response to peptide|cellular response to organonitrogen compound|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|response to peptide hormone|energy reserve metabolic process|cellular response to organic substance|cellular response to hormone stimulus|cellular response to peptide|cellular response to peptide hormone stimulus|response to glucagon|pyrophosphatase activity|cellular response to glucagon stimulus|nucleoside-triphosphatase activity|GTPase activity K04546 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11[-] hsa05200|hsa04151|hsa04014|hsa04062|hsa05034|hsa04728|hsa04724|hsa04726|hsa04725|hsa04723|hsa04713|hsa05032|hsa04727 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human) 7:93921699-93928610 71 76 87 51 46 19 1.64396559169914 1.59929131195066 1.81621068832397 1.0580449445599 0.873893958069246 0.412297936391963 1.68648919732459 0.781412279673703 1.10986724495649 0.00124711393510702 0.00718058619453905 UP ENSG00000258539 RP11-12J10.3 - GO:0008152|GO:0003824|GO:0032259|GO:0016740|GO:0008168 metabolic process|catalytic activity|methylation|transferase activity|methyltransferase activity - - - - 10:124617080-124791727 1 3 0 11 3 18 0.020679922098952 0.0563683024240439 0 0.203728030265681 0.0508859033910357 0.34870965818227 0.0256827415076653 0.201107863946329 -2.96909838016629 0.00125769742757536 0.00723454701403365 DOWN ENSG00000197982 C1orf122 chromosome 1 open reading frame 122 [Source:HGNC Symbol;Acc:HGNC:24789] - - - - - - 1:37806979-37809454 1397 1480 563 597 783 451 23.2242990774465 22.3608293244781 8.43857630349571 8.89238982400598 10.6801086210596 7.02670001248464 18.0079015684734 8.86639948585007 1.02220980475975 0.00126214871605258 0.00725595759080182 UP ENSG00000179133 C10orf67 chromosome 10 open reading frame 67 [Source:HGNC Symbol;Acc:HGNC:28716] - - - - - - 10:23267195-23344845 19 26 20 60 59 41 0.401544913800294 0.499393443100032 0.381105778289295 1.13615862563071 1.02308855505033 0.812090870701658 0.427348045063207 0.990446017127566 -1.21266682250813 0.00126990864929617 0.00729212604006027 DOWN ENSG00000264247 LINC00909 long intergenic non-protein coding RNA 909 [Source:HGNC Symbol;Acc:HGNC:44331] - - - - - - 18:74591774-74598508 51 57 35 110 117 99 0.645016513986888 0.65517730076253 0.39910574748938 1.24649335131479 1.2141054103205 1.17345521069174 0.566433187412933 1.21135132410901 -1.09663964491375 0.00127203331262452 0.00730153480390163 DOWN ENSG00000275713 HIST1H2BH histone cluster 1, H2bh [Source:HGNC Symbol;Acc:HGNC:4755] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0097159|GO:0043229|GO:0000785|GO:0016043|GO:0043227|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0003676|GO:0031982|GO:0022607|GO:0043231|GO:0005737|GO:0046983|GO:0000790|GO:0070062|GO:0000786|GO:0006996|GO:0051276|GO:0003677|GO:0046982|GO:0006325|GO:0000788|GO:0031981|GO:0005654|GO:0005694|GO:0000228|GO:0006461|GO:0005634|GO:0006334|GO:0034622|GO:0034728|GO:0006333|GO:0065004|GO:0031497|GO:0071103|GO:0006323 macromolecular complex|cell|cellular process|extracellular region|binding|extracellular vesicle|organic cyclic compound binding|intracellular organelle|chromatin|cellular component organization|membrane-bounded organelle|protein-DNA complex|intracellular|protein binding|protein complex|nucleic acid binding|vesicle|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|nuclear chromatin|extracellular exosome|nucleosome|organelle organization|chromosome organization|DNA binding|protein heterodimerization activity|chromatin organization|nuclear nucleosome|nuclear lumen|nucleoplasm|chromosome|nuclear chromosome|protein complex assembly|nucleus|nucleosome assembly|cellular macromolecular complex assembly|nucleosome organization|chromatin assembly or disassembly|protein-DNA complex assembly|chromatin assembly|DNA conformation change|DNA packaging K11252 histone H2B[-] hsa05203|hsa05034|hsa05322 Viral carcinogenesis - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) 6:26251651-26253710 0 0 0 5 3 3 0 0 0 0.153821458217549 0.0845298841767593 0.0965326388995894 0 0.111627993764633 -Inf 0.00127391198668917 0.00730950767838141 DOWN ENSG00000116039 ATP6V1B1 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1 [Source:HGNC Symbol;Acc:HGNC:853] GO:0032502|GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0042995|GO:0097159|GO:0022857|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0045177|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0006725|GO:0016323|GO:0006810|GO:1901360|GO:0048839|GO:0016324|GO:0007275|GO:0048513|GO:0050877|GO:0034641|GO:0043168|GO:0044281|GO:0001882|GO:0031982|GO:0019637|GO:0046483|GO:0016817|GO:0043231|GO:0010243|GO:0005774|GO:0005737|GO:0007423|GO:0009887|GO:0032403|GO:0042592|GO:0048598|GO:0048568|GO:0033178|GO:0045184|GO:0019725|GO:0022891|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0070062|GO:0016328|GO:0001503|GO:0009725|GO:0007588|GO:0016469|GO:0000166|GO:0010033|GO:0006996|GO:0016820|GO:0005829|GO:0007166|GO:0035639|GO:0043583|GO:0019693|GO:0048878|GO:0016471|GO:0001883|GO:0015031|GO:1901652|GO:0005773|GO:0009790|GO:0071417|GO:0009116|GO:0006811|GO:0033176|GO:0032549|GO:0055082|GO:0042472|GO:0015075|GO:0090382|GO:0007600|GO:0043434|GO:0033180|GO:0006796|GO:0048562|GO:0071310|GO:0017076|GO:0005902|GO:0090662|GO:0032870|GO:0034220|GO:0033572|GO:0098655|GO:0050954|GO:0009259|GO:1901653|GO:0009117|GO:0015992|GO:0005524|GO:0006812|GO:0030554|GO:0015991|GO:0042471|GO:0007167|GO:0071375|GO:0006163|GO:0050801|GO:0032868|GO:0042278|GO:0006873|GO:0008324|GO:0007605|GO:1902600|GO:0032869|GO:0022890|GO:0030001|GO:0030003|GO:0015672|GO:0007169|GO:0046034|GO:0055065|GO:0006875|GO:0015077|GO:0008286|GO:0015078|GO:0006885|GO:0055074|GO:0006826|GO:0006879|GO:0055072|GO:0045851 developmental process|macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|cell projection|organic cyclic compound binding|transmembrane transporter activity|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|apical part of cell|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|cellular aromatic compound metabolic process|basolateral plasma membrane|transport|organic cyclic compound metabolic process|inner ear development|apical plasma membrane|multicellular organism development|animal organ development|neurological system process|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|nucleoside binding|vesicle|organophosphate metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|response to organonitrogen compound|vacuolar membrane|cytoplasm|sensory organ development|organ morphogenesis|protein complex binding|homeostatic process|embryonic morphogenesis|embryonic organ development|proton-transporting two-sector ATPase complex, catalytic domain|establishment of protein localization|cellular homeostasis|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|transmembrane transport|signal transduction|extracellular exosome|lateral plasma membrane|ossification|response to hormone|excretion|proton-transporting two-sector ATPase complex|nucleotide binding|response to organic substance|organelle organization|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|cytosol|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|ear development|ribose phosphate metabolic process|chemical homeostasis|vacuolar proton-transporting V-type ATPase complex|purine nucleoside binding|protein transport|response to peptide|vacuole|embryo development|cellular response to organonitrogen compound|nucleoside metabolic process|ion transport|proton-transporting V-type ATPase complex|ribonucleoside binding|cellular chemical homeostasis|inner ear morphogenesis|ion transmembrane transporter activity|phagosome maturation|sensory perception|response to peptide hormone|proton-transporting V-type ATPase, V1 domain|phosphate-containing compound metabolic process|embryonic organ morphogenesis|cellular response to organic substance|purine nucleotide binding|microvillus|ATP hydrolysis coupled transmembrane transport|cellular response to hormone stimulus|ion transmembrane transport|transferrin transport|cation transmembrane transport|sensory perception of mechanical stimulus|ribonucleotide metabolic process|cellular response to peptide|nucleotide metabolic process|proton transport|ATP binding|cation transport|adenyl nucleotide binding|ATP hydrolysis coupled proton transport|ear morphogenesis|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|purine nucleotide metabolic process|ion homeostasis|response to insulin|purine nucleoside metabolic process|cellular ion homeostasis|cation transmembrane transporter activity|sensory perception of sound|hydrogen ion transmembrane transport|cellular response to insulin stimulus|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|monovalent inorganic cation transport|transmembrane receptor protein tyrosine kinase signaling pathway|ATP metabolic process|metal ion homeostasis|cellular metal ion homeostasis|monovalent inorganic cation transmembrane transporter activity|insulin receptor signaling pathway|hydrogen ion transmembrane transporter activity|regulation of pH|calcium ion homeostasis|iron ion transport|cellular iron ion homeostasis|iron ion homeostasis|pH reduction K02147 V-type H+-transporting ATPase subunit B[-] hsa01100|hsa04145|hsa00190|hsa05323|hsa05120|hsa04721|hsa05110|hsa04966 Metabolic pathways - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Synaptic vesicle cycle - Homo sapiens (human)|Vibrio cholerae infection - Homo sapiens (human)|Collecting duct acid secretion - Homo sapiens (human) 2:70935882-70965406 7 4 19 24 29 51 0.100541740327229 0.0522130372215793 0.24604053071283 0.308847988700911 0.341741730438597 0.686496673048941 0.132931769420546 0.445695464062816 -1.74537234228455 0.00128558737749888 0.00737224847634491 DOWN ENSG00000279852 RP11-91J19.2 - - - - - - - 8:486117-488512 23 16 11 3 5 8 0.679036452099809 0.42929750970998 0.292790149326786 0.0793449493800006 0.121118487155215 0.221350784545971 0.467041370378858 0.140604740360396 1.73190511469583 0.00128950939446953 0.007393319274533 UP ENSG00000146151 HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 [Source:HGNC Symbol;Acc:HGNC:21359] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0016829|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0016830|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0005783|GO:0046950|GO:0044249|GO:0005829|GO:0046872|GO:0046951|GO:0048471|GO:0004419 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|lyase activity|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|carbon-carbon lyase activity|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|endoplasmic reticulum|cellular ketone body metabolic process|cellular biosynthetic process|cytosol|metal ion binding|ketone body biosynthetic process|perinuclear region of cytoplasm|hydroxymethylglutaryl-CoA lyase activity K01640 hydroxymethylglutaryl-CoA lyase[4.1.3.4] hsa01100|hsa04146|hsa00280|hsa00650|hsa00072 Metabolic pathways - Homo sapiens (human)|Peroxisome - Homo sapiens (human)|Valine, leucine and isoleucine degradation - Homo sapiens (human)|Butanoate metabolism - Homo sapiens (human)|Synthesis and degradation of ketone bodies - Homo sapiens (human) 6:55434369-55579214 2 2 20 23 33 50 0.0135323441645619 0.0122990820889745 0.122016552509496 0.13944208445104 0.183209566806827 0.317075795809099 0.0492826595876775 0.213242482355655 -2.11334286199331 0.00129158721351177 0.00740226213673503 DOWN ENSG00000182676 PPP1R27 protein phosphatase 1 regulatory subunit 27 [Source:HGNC Symbol;Acc:HGNC:16813] GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0071704|GO:0044237|GO:0030234|GO:0005515|GO:0019222|GO:0004857|GO:0019208|GO:0019899|GO:0044092|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0043412|GO:0036211|GO:0032269|GO:0019902|GO:0051346|GO:0019212|GO:0006796|GO:0044267|GO:0051174|GO:0019888|GO:0051246|GO:0010923|GO:0016311|GO:0004864|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0035305|GO:0035303|GO:0035308 cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|cellular metabolic process|enzyme regulator activity|protein binding|regulation of metabolic process|enzyme inhibitor activity|phosphatase regulator activity|enzyme binding|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|protein modification process|negative regulation of cellular protein metabolic process|phosphatase binding|negative regulation of hydrolase activity|phosphatase inhibitor activity|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|protein phosphatase regulator activity|regulation of protein metabolic process|negative regulation of phosphatase activity|dephosphorylation|protein phosphatase inhibitor activity|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation - - - - 17:81833492-81835050 11 9 7 1 2 4 0.294178571986489 0.218758466302267 0.168776177618195 0.0239503945182654 0.0438821677957549 0.100243093198818 0.22723773863565 0.0560252185042794 2.02005417561066 0.00129157623088672 0.00740226213673503 UP ENSG00000280378 RP4-758J24.6 - - - - - - - 1:54033126-54034880 34 30 32 14 12 18 1.3704123430971 1.09892824066785 1.16286661854193 0.505602243017485 0.396847934055592 0.679934159714946 1.21073573410229 0.527461445596008 1.19874645394407 0.00129224392515518 0.00740331033229378 UP ENSG00000185499 MUC1 mucin 1, cell surface associated [Source:HGNC Symbol;Acc:HGNC:7508] GO:0032502|GO:0032991|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:1903561|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0044237|GO:0045177|GO:0023051|GO:0000989|GO:0000785|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0023057|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0006486|GO:0051726|GO:0007049|GO:0003712|GO:0006725|GO:0009888|GO:0022402|GO:0051130|GO:1901360|GO:0010941|GO:0016324|GO:0007275|GO:0016570|GO:0003676|GO:0002039|GO:0034641|GO:0030155|GO:0031982|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0005887|GO:0045786|GO:0043231|GO:0005737|GO:0033627|GO:0005975|GO:0009966|GO:0009890|GO:0045787|GO:0060548|GO:0010646|GO:0006139|GO:0031226|GO:0007162|GO:0000790|GO:0007154|GO:0007565|GO:0007165|GO:0009968|GO:0070062|GO:0008219|GO:0001666|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0005794|GO:0006996|GO:0051276|GO:0032268|GO:1902230|GO:0003677|GO:0010468|GO:0000075|GO:0034645|GO:0090068|GO:0033993|GO:1903047|GO:0043412|GO:0010629|GO:0043620|GO:0043069|GO:0031056|GO:2001234|GO:0051252|GO:0006325|GO:0044770|GO:0007050|GO:0009790|GO:0031058|GO:0016573|GO:0010628|GO:0006493|GO:0009100|GO:0036211|GO:0033628|GO:0000278|GO:0005796|GO:0031981|GO:2001020|GO:0007346|GO:0010564|GO:0051247|GO:0045930|GO:0070085|GO:0005694|GO:0000228|GO:0033629|GO:0032270|GO:0012501|GO:0060429|GO:0032526|GO:0035556|GO:1901137|GO:0033043|GO:0044267|GO:0010467|GO:0071310|GO:1902532|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0072395|GO:1902531|GO:0016070|GO:0010557|GO:0005634|GO:0043067|GO:0006974|GO:0097190|GO:0010948|GO:0010638|GO:2001252|GO:0000975|GO:0009101|GO:0045893|GO:0097193|GO:0043413|GO:2001242|GO:0009792|GO:0031401|GO:1901797|GO:0071156|GO:0030855|GO:0045892|GO:0007093|GO:0072331|GO:0042770|GO:0032774|GO:0044772|GO:0043565|GO:2001141|GO:2001243|GO:0043967|GO:0033044|GO:0044774|GO:1902679|GO:0000077|GO:0035066|GO:0003690|GO:1902166|GO:1901990|GO:0008630|GO:1901796|GO:0042981|GO:0035065|GO:0043066|GO:0016568|GO:1901987|GO:0071300|GO:0006464|GO:0071396|GO:0006351|GO:0006915|GO:0006355|GO:0043618|GO:0044773|GO:1901991|GO:0071158|GO:0016266|GO:0045944|GO:2000045|GO:0006366|GO:0072332|GO:1903507|GO:0006357|GO:0044819|GO:0090240|GO:0042771|GO:0090239|GO:1903506|GO:0044212|GO:0044783|GO:0036003|GO:1902806|GO:0018193|GO:2000134|GO:0000082|GO:0043009|GO:0043687|GO:1901985|GO:1902165|GO:1902254|GO:0010944|GO:1902253|GO:0031571|GO:0042772|GO:1902807|GO:0006977|GO:0030330|GO:0072422|GO:0072431|GO:0000976|GO:0001012|GO:0001701|GO:0001159|GO:0006978|GO:0006473|GO:0018205|GO:0018394|GO:0000977|GO:0000987|GO:0006475|GO:0018393|GO:0000978 developmental process|macromolecular complex|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|apical part of cell|regulation of signaling|transcription factor activity, transcription factor binding|chromatin|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|protein glycosylation|regulation of cell cycle|cell cycle|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell cycle process|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|apical plasma membrane|multicellular organism development|histone modification|nucleic acid binding|p53 binding|cellular nitrogen compound metabolic process|regulation of cell adhesion|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|integral component of plasma membrane|negative regulation of cell cycle|intracellular membrane-bounded organelle|cytoplasm|cell adhesion mediated by integrin|carbohydrate metabolic process|regulation of signal transduction|negative regulation of biosynthetic process|positive regulation of cell cycle|negative regulation of cell death|regulation of cell communication|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|negative regulation of cell adhesion|nuclear chromatin|cell communication|female pregnancy|signal transduction|negative regulation of signal transduction|extracellular exosome|cell death|response to hypoxia|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|organelle organization|chromosome organization|regulation of cellular protein metabolic process|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|DNA binding|regulation of gene expression|cell cycle checkpoint|cellular macromolecule biosynthetic process|positive regulation of cell cycle process|response to lipid|mitotic cell cycle process|macromolecule modification|negative regulation of gene expression|regulation of DNA-templated transcription in response to stress|negative regulation of programmed cell death|regulation of histone modification|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|chromatin organization|cell cycle phase transition|cell cycle arrest|embryo development|positive regulation of histone modification|histone acetylation|positive regulation of gene expression|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|regulation of cell adhesion mediated by integrin|mitotic cell cycle|Golgi lumen|nuclear lumen|regulation of response to DNA damage stimulus|regulation of mitotic cell cycle|regulation of cell cycle process|positive regulation of protein metabolic process|negative regulation of mitotic cell cycle|glycosylation|chromosome|nuclear chromosome|negative regulation of cell adhesion mediated by integrin|positive regulation of cellular protein metabolic process|programmed cell death|epithelium development|response to retinoic acid|intracellular signal transduction|carbohydrate derivative biosynthetic process|regulation of organelle organization|cellular protein metabolic process|gene expression|cellular response to organic substance|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|signal transduction involved in cell cycle checkpoint|regulation of intracellular signal transduction|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|cellular response to DNA damage stimulus|apoptotic signaling pathway|negative regulation of cell cycle process|positive regulation of organelle organization|positive regulation of chromosome organization|regulatory region DNA binding|glycoprotein biosynthetic process|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|macromolecule glycosylation|regulation of intrinsic apoptotic signaling pathway|embryo development ending in birth or egg hatching|positive regulation of protein modification process|negative regulation of signal transduction by p53 class mediator|regulation of cell cycle arrest|epithelial cell differentiation|negative regulation of transcription, DNA-templated|mitotic cell cycle checkpoint|signal transduction by p53 class mediator|signal transduction in response to DNA damage|RNA biosynthetic process|mitotic cell cycle phase transition|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway|histone H4 acetylation|regulation of chromosome organization|mitotic DNA integrity checkpoint|negative regulation of RNA biosynthetic process|DNA damage checkpoint|positive regulation of histone acetylation|double-stranded DNA binding|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of mitotic cell cycle phase transition|intrinsic apoptotic signaling pathway in response to DNA damage|regulation of signal transduction by p53 class mediator|regulation of apoptotic process|regulation of histone acetylation|negative regulation of apoptotic process|chromatin modification|regulation of cell cycle phase transition|cellular response to retinoic acid|cellular protein modification process|cellular response to lipid|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|mitotic DNA damage checkpoint|negative regulation of mitotic cell cycle phase transition|positive regulation of cell cycle arrest|O-glycan processing|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|mitotic G1/S transition checkpoint|positive regulation of histone H4 acetylation|intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|regulation of histone H4 acetylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|G1 DNA damage checkpoint|positive regulation of transcription from RNA polymerase II promoter in response to stress|regulation of cell cycle G1/S phase transition|peptidyl-amino acid modification|negative regulation of G1/S transition of mitotic cell cycle|G1/S transition of mitotic cell cycle|chordate embryonic development|post-translational protein modification|positive regulation of protein acetylation|regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|negative regulation of transcription by competitive promoter binding|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|mitotic G1 DNA damage checkpoint|DNA damage response, signal transduction resulting in transcription|negative regulation of cell cycle G1/S phase transition|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|signal transduction involved in DNA damage checkpoint|signal transduction involved in mitotic G1 DNA damage checkpoint|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|core promoter proximal region DNA binding|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|internal protein amino acid acetylation|internal peptidyl-lysine acetylation|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 1:155185824-155192916 106 98 199 258 208 578 0.738509699325321 0.620521580197854 1.25002777304779 1.6105272243332 1.1890003364662 3.77405259207607 0.869686350856988 2.19119338429182 -1.3331497180587 0.00129474940882468 0.00741624114563544 DOWN ENSG00000105737 GRIK5 glutamate receptor, ionotropic, kainate 5 [Source:HGNC Symbol;Acc:HGNC:4583] GO:0032991|GO:0004871|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0031629|GO:0051716|GO:0042995|GO:0004872|GO:0022857|GO:0050794|GO:0060076|GO:0043229|GO:0016079|GO:0051641|GO:0038023|GO:0023051|GO:0044297|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0097060|GO:0042802|GO:0060341|GO:0050804|GO:0042391|GO:0030594|GO:0051640|GO:0043025|GO:0006810|GO:0043195|GO:0010941|GO:0098797|GO:0060627|GO:0032940|GO:0051128|GO:0045211|GO:0010942|GO:0051668|GO:0005887|GO:0043231|GO:0004888|GO:0051651|GO:0005737|GO:0007267|GO:0042734|GO:0043235|GO:0042592|GO:0051656|GO:0043005|GO:0043204|GO:0019725|GO:0036477|GO:0014069|GO:0022891|GO:0019904|GO:0010646|GO:0031226|GO:0008104|GO:0031630|GO:1902495|GO:0007154|GO:0055085|GO:0061024|GO:0007165|GO:0005783|GO:0051649|GO:0044306|GO:0008219|GO:0001505|GO:2000300|GO:0016021|GO:0010033|GO:0006996|GO:0046928|GO:0061025|GO:0016192|GO:0006836|GO:0051650|GO:0043113|GO:0009743|GO:0008328|GO:0016050|GO:0007166|GO:0030424|GO:0048878|GO:0017124|GO:0032386|GO:0060078|GO:1901216|GO:0070997|GO:0030165|GO:0048489|GO:0006887|GO:0015267|GO:0046907|GO:0006811|GO:0055082|GO:0043679|GO:0015075|GO:0017157|GO:1902803|GO:0051046|GO:0072657|GO:0030425|GO:0032507|GO:0008066|GO:0034702|GO:1901214|GO:0034613|GO:0012501|GO:0033043|GO:0031338|GO:0046903|GO:0071310|GO:0051648|GO:0043068|GO:0043067|GO:0048284|GO:0034220|GO:0071322|GO:0051220|GO:0015276|GO:0033365|GO:0005216|GO:0022824|GO:0045055|GO:0001678|GO:0007215|GO:0043065|GO:0043523|GO:0032983|GO:0045026|GO:0004970|GO:0034284|GO:0043525|GO:0016482|GO:0006906|GO:1903305|GO:0042981|GO:0051402|GO:0060079|GO:0006915|GO:0033500|GO:0071333|GO:0070972|GO:0042593|GO:0015277|GO:0035235|GO:0017156|GO:0035437|GO:0005230|GO:0017158|GO:0007268|GO:0005231|GO:0007270|GO:0006621|GO:0009749|GO:0005234|GO:0035249 macromolecular complex|signal transducer activity|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|synaptic vesicle fusion to presynaptic active zone membrane|cellular response to stimulus|cell projection|receptor activity|transmembrane transporter activity|regulation of cellular process|excitatory synapse|intracellular organelle|synaptic vesicle exocytosis|cellular localization|signaling receptor activity|regulation of signaling|cell body|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|neurotransmitter secretion|protein binding|plasma membrane|protein complex|endomembrane system|synaptic membrane|identical protein binding|regulation of cellular localization|modulation of synaptic transmission|regulation of membrane potential|neurotransmitter receptor activity|organelle localization|neuronal cell body|transport|terminal bouton|regulation of cell death|plasma membrane protein complex|regulation of vesicle-mediated transport|secretion by cell|regulation of cellular component organization|postsynaptic membrane|positive regulation of cell death|localization within membrane|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|maintenance of location in cell|cytoplasm|cell-cell signaling|presynaptic membrane|receptor complex|homeostatic process|establishment of organelle localization|neuron projection|perikaryon|cellular homeostasis|somatodendritic compartment|postsynaptic density|substrate-specific transmembrane transporter activity|protein domain specific binding|regulation of cell communication|intrinsic component of plasma membrane|protein localization|regulation of synaptic vesicle fusion to presynaptic membrane|transmembrane transporter complex|cell communication|transmembrane transport|membrane organization|signal transduction|endoplasmic reticulum|establishment of localization in cell|neuron projection terminus|cell death|regulation of neurotransmitter levels|regulation of synaptic vesicle exocytosis|integral component of membrane|response to organic substance|organelle organization|regulation of neurotransmitter secretion|membrane fusion|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|receptor clustering|response to carbohydrate|ionotropic glutamate receptor complex|vesicle organization|cell surface receptor signaling pathway|axon|chemical homeostasis|SH3 domain binding|regulation of intracellular transport|regulation of postsynaptic membrane potential|positive regulation of neuron death|neuron death|PDZ domain binding|synaptic vesicle transport|exocytosis|channel activity|intracellular transport|ion transport|cellular chemical homeostasis|axon terminus|ion transmembrane transporter activity|regulation of exocytosis|regulation of synaptic vesicle transport|regulation of secretion|protein localization to membrane|dendrite|maintenance of protein location in cell|glutamate receptor activity|ion channel complex|regulation of neuron death|cellular protein localization|programmed cell death|regulation of organelle organization|regulation of vesicle fusion|secretion|cellular response to organic substance|vesicle localization|positive regulation of programmed cell death|regulation of programmed cell death|organelle fusion|ion transmembrane transport|cellular response to carbohydrate stimulus|cytoplasmic sequestering of protein|ligand-gated ion channel activity|protein localization to organelle|ion channel activity|transmitter-gated ion channel activity|regulated exocytosis|cellular glucose homeostasis|glutamate receptor signaling pathway|positive regulation of apoptotic process|regulation of neuron apoptotic process|kainate selective glutamate receptor complex|plasma membrane fusion|ionotropic glutamate receptor activity|response to monosaccharide|positive regulation of neuron apoptotic process|cytosolic transport|vesicle fusion|regulation of regulated secretory pathway|regulation of apoptotic process|neuron apoptotic process|excitatory postsynaptic potential|apoptotic process|carbohydrate homeostasis|cellular response to glucose stimulus|protein localization to endoplasmic reticulum|glucose homeostasis|kainate selective glutamate receptor activity|ionotropic glutamate receptor signaling pathway|calcium ion regulated exocytosis|maintenance of protein localization in endoplasmic reticulum|extracellular ligand-gated ion channel activity|regulation of calcium ion-dependent exocytosis|synaptic transmission|excitatory extracellular ligand-gated ion channel activity|neuron-neuron synaptic transmission|protein retention in ER lumen|response to glucose|extracellular-glutamate-gated ion channel activity|synaptic transmission, glutamatergic K05205 glutamate receptor, ionotropic kainate 5[-] hsa04080|hsa04724 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human) 19:41998321-42069498 3 4 5 19 11 17 0.0340828359272433 0.0412958420292722 0.0512055381093141 0.193384316753467 0.102522064667289 0.180985820607357 0.0421947386886099 0.158964067342704 -1.91356566784204 0.00129804148138502 0.00743367166416042 DOWN ENSG00000259040 BLOC1S5-TXNDC5 BLOC1S5-TXNDC5 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:42001] GO:0032991|GO:0005623|GO:0043229|GO:0051641|GO:0043227|GO:0005622|GO:0043234|GO:0012505|GO:0006810|GO:0031982|GO:0043231|GO:0030133|GO:0005737|GO:0051649|GO:0005829|GO:0031410|GO:0016023|GO:0046907|GO:0031988|GO:0031083|GO:0016197 macromolecular complex|cell|intracellular organelle|cellular localization|membrane-bounded organelle|intracellular|protein complex|endomembrane system|transport|vesicle|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|establishment of localization in cell|cytosol|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|intracellular transport|membrane-bounded vesicle|BLOC-1 complex|endosomal transport - - - - 6:7881522-8064364 0 0 0 0 56 0 0 0 0 0 1.0726553902143 0 0 0.3575517967381 -Inf 0.00130042060803032 0.00744444042802247 DOWN ENSG00000258824 CTD-2555O16.2 - - - - - - - 14:64422935-64448557 5 8 8 23 19 23 0.643092627664135 0.935088030241011 0.927680756315833 2.65041372882032 2.0049751878386 2.77233398897949 0.83528713807366 2.4759076352128 -1.56761336679806 0.00130067271597114 0.00744445614697134 DOWN ENSG00000260953 RP11-426C22.6 - - - - - - - 16:29262273-29264479 2 3 3 14 14 9 0.252169564877594 0.343836596960924 0.34099961107535 1.58169685649855 1.44837158304338 1.06353337816375 0.312335257637956 1.36453393923523 -2.12724093756753 0.00130248749954298 0.00745341418657392 DOWN ENSG00000108578 BLMH bleomycin hydrolase [Source:HGNC Symbol;Acc:HGNC:1059] GO:0002376|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0019882|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0031982|GO:0043231|GO:0008233|GO:0005737|GO:0042493|GO:0070062|GO:0048002|GO:0019538|GO:0009636|GO:0005829|GO:0043412|GO:0036211|GO:0006508|GO:0002474|GO:0044267|GO:0005634|GO:0004175|GO:0008238|GO:0008234|GO:0006464|GO:0004180|GO:0004197|GO:0004177|GO:0032446|GO:0016567|GO:0000209 immune system process|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|antigen processing and presentation|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|vesicle|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|response to drug|extracellular exosome|antigen processing and presentation of peptide antigen|protein metabolic process|response to toxic substance|cytosol|macromolecule modification|protein modification process|proteolysis|antigen processing and presentation of peptide antigen via MHC class I|cellular protein metabolic process|nucleus|endopeptidase activity|exopeptidase activity|cysteine-type peptidase activity|cellular protein modification process|carboxypeptidase activity|cysteine-type endopeptidase activity|aminopeptidase activity|protein modification by small protein conjugation|protein ubiquitination|protein polyubiquitination - - - - 17:30248195-30292056 23 18 24 48 57 50 0.180975677333831 0.128717623740072 0.170256562799487 0.338392957586649 0.36798119450331 0.368710830855208 0.159983287957797 0.358361660981722 -1.16349509278145 0.00130839033600996 0.00748145663498206 DOWN ENSG00000179583 CIITA class II, major histocompatibility complex, transactivator [Source:HGNC Symbol;Acc:HGNC:7067] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0009986|GO:0044237|GO:0000989|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0019222|GO:0045087|GO:0003712|GO:0006725|GO:0051602|GO:0008022|GO:1901360|GO:0003676|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0016772|GO:0031325|GO:0046483|GO:0044252|GO:0043231|GO:0016746|GO:0032403|GO:0009890|GO:0044236|GO:0006139|GO:0007154|GO:0007165|GO:0008134|GO:0000166|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0007568|GO:0009636|GO:0003713|GO:0003677|GO:0044259|GO:0010468|GO:0034645|GO:0010712|GO:0007166|GO:0035639|GO:0034097|GO:0032964|GO:0010629|GO:0071257|GO:0051252|GO:0001883|GO:0010628|GO:0043331|GO:0006954|GO:0032549|GO:0034341|GO:0031981|GO:0005654|GO:0016301|GO:0046677|GO:0014070|GO:0006796|GO:0010467|GO:0071310|GO:0017076|GO:0031328|GO:0009059|GO:0016070|GO:0033613|GO:0010557|GO:0005634|GO:0045345|GO:0032966|GO:0000975|GO:0032561|GO:0045893|GO:0019221|GO:0045343|GO:0071346|GO:0045892|GO:0045348|GO:0032774|GO:0005524|GO:0071359|GO:2001141|GO:0030554|GO:0016310|GO:1902679|GO:0071407|GO:0016604|GO:0071345|GO:0045342|GO:0005525|GO:0043330|GO:0019001|GO:0006351|GO:0006355|GO:0032963|GO:0045944|GO:0006366|GO:1903507|GO:0060333|GO:0006357|GO:1903506|GO:0044212|GO:0071360|GO:0016605|GO:0000122 developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cell surface|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|transferase activity|regulation of metabolic process|innate immune response|transcription cofactor activity|cellular aromatic compound metabolic process|response to electrical stimulus|protein C-terminus binding|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|heterocycle metabolic process|negative regulation of multicellular organismal metabolic process|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|protein complex binding|negative regulation of biosynthetic process|multicellular organism metabolic process|nucleobase-containing compound metabolic process|cell communication|signal transduction|transcription factor binding|nucleotide binding|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|aging|response to toxic substance|transcription coactivator activity|DNA binding|multicellular organismal macromolecule metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of collagen metabolic process|cell surface receptor signaling pathway|purine ribonucleoside triphosphate binding|response to cytokine|collagen biosynthetic process|negative regulation of gene expression|cellular response to electrical stimulus|regulation of RNA metabolic process|purine nucleoside binding|positive regulation of gene expression|response to dsRNA|inflammatory response|ribonucleoside binding|response to interferon-gamma|nuclear lumen|nucleoplasm|kinase activity|response to antibiotic|response to organic cyclic compound|phosphate-containing compound metabolic process|gene expression|cellular response to organic substance|purine nucleotide binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|activating transcription factor binding|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of MHC class I biosynthetic process|negative regulation of collagen biosynthetic process|regulatory region DNA binding|guanyl ribonucleotide binding|positive regulation of transcription, DNA-templated|cytokine-mediated signaling pathway|regulation of MHC class I biosynthetic process|cellular response to interferon-gamma|negative regulation of transcription, DNA-templated|positive regulation of MHC class II biosynthetic process|RNA biosynthetic process|ATP binding|cellular response to dsRNA|regulation of RNA biosynthetic process|adenyl nucleotide binding|phosphorylation|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|nuclear body|cellular response to cytokine stimulus|MHC class II biosynthetic process|GTP binding|response to exogenous dsRNA|guanyl nucleotide binding|transcription, DNA-templated|regulation of transcription, DNA-templated|collagen metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|interferon-gamma-mediated signaling pathway|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|cellular response to exogenous dsRNA|PML body|negative regulation of transcription from RNA polymerase II promoter K08060 class II, major histocompatibility complex, transactivator[-] hsa05152|hsa05164|hsa05145|hsa04612|hsa05340 Tuberculosis - Homo sapiens (human)|Influenza A - Homo sapiens (human)|Toxoplasmosis - Homo sapiens (human)|Antigen processing and presentation - Homo sapiens (human)|Primary immunodeficiency - Homo sapiens (human) 16:10877198-10932281 54 42 88 32 21 34 0.149322199368578 0.105549692635977 0.219394671005954 0.07928240354977 0.0476449195547868 0.088112169572887 0.158088854336836 0.0716798308924813 1.14109651874393 0.00131021642448907 0.00749046364165008 UP ENSG00000255835 RP4-559A3.7 - GO:0009987|GO:0008152|GO:0003824|GO:0016491|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:1901360|GO:0006082|GO:0044281|GO:0046483|GO:0006520|GO:0044249|GO:0055114|GO:0006560|GO:0008652|GO:0019752|GO:0006561|GO:0004735 cellular process|metabolic process|catalytic activity|oxidoreductase activity|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|organic cyclic compound metabolic process|organic acid metabolic process|small molecule metabolic process|heterocycle metabolic process|cellular amino acid metabolic process|cellular biosynthetic process|oxidation-reduction process|proline metabolic process|cellular amino acid biosynthetic process|carboxylic acid metabolic process|proline biosynthetic process|pyrroline-5-carboxylate reductase activity - - - - 1:225886696-225924278 109 121 60 46 62 35 4.7448140286578 4.78695013921555 2.35484084396866 1.79408675907096 2.21436974388225 1.42786655705953 3.962201670614 1.81210768667091 1.12863362147562 0.0013109614367511 0.00749328790594818 UP ENSG00000224945 RP11-82L18.2 - - - - - - - 9:89088604-89109934 4 4 8 20 11 31 0.242238229274538 0.220161993421471 0.436835972580229 1.08523367630535 0.546579534831516 1.75953781995794 0.299745398425413 1.13045034369827 -1.91508811025041 0.00131273171841879 0.00750197027597139 DOWN ENSG00000091138 SLC26A3 solute carrier family 26 (anion exchanger), member 3 [Source:HGNC Symbol;Acc:HGNC:3018] GO:0032502|GO:0000003|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0042995|GO:0022857|GO:0003700|GO:0050794|GO:0006807|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0045177|GO:0003006|GO:0000989|GO:0071944|GO:0032504|GO:0009058|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0048609|GO:0019222|GO:0005903|GO:0042391|GO:0003712|GO:0006725|GO:0036126|GO:0048468|GO:0006810|GO:1901360|GO:0016324|GO:0034641|GO:0046483|GO:0097225|GO:0005887|GO:0031514|GO:0010243|GO:0048240|GO:0042592|GO:0048515|GO:0019725|GO:0022891|GO:0006139|GO:0031226|GO:0055085|GO:0007276|GO:0007588|GO:0031253|GO:0048869|GO:0016021|GO:0044249|GO:0010033|GO:0007281|GO:0031323|GO:0010468|GO:0007286|GO:0034645|GO:0048232|GO:0014074|GO:0060081|GO:0048878|GO:0051252|GO:0031526|GO:0046683|GO:0071417|GO:0015267|GO:0006811|GO:0055082|GO:0015075|GO:0051591|GO:0014070|GO:0010467|GO:0071310|GO:0009059|GO:0030154|GO:0048469|GO:0016070|GO:0015116|GO:0034220|GO:0007283|GO:0006820|GO:0015711|GO:0005216|GO:0098656|GO:0032774|GO:0015297|GO:0008509|GO:2001141|GO:0008272|GO:0071407|GO:0046942|GO:0046943|GO:0050801|GO:0008271|GO:0071320|GO:0006351|GO:0006355|GO:0006873|GO:1902358|GO:0005253|GO:0006835|GO:1903506|GO:0015301|GO:0008514|GO:0015701|GO:0015698|GO:0030003|GO:0005310|GO:0005254|GO:0015106|GO:1902476|GO:0006821|GO:0019532|GO:0019531|GO:0015108|GO:0006885|GO:0030641|GO:0051453|GO:0051454 developmental process|reproduction|transporter activity|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|cell projection|transmembrane transporter activity|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|apical part of cell|developmental process involved in reproduction|transcription factor activity, transcription factor binding|cell periphery|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|cilium|multicellular organismal reproductive process|regulation of metabolic process|brush border|regulation of membrane potential|transcription cofactor activity|cellular aromatic compound metabolic process|sperm flagellum|cell development|transport|organic cyclic compound metabolic process|apical plasma membrane|cellular nitrogen compound metabolic process|heterocycle metabolic process|sperm midpiece|integral component of plasma membrane|motile cilium|response to organonitrogen compound|sperm capacitation|homeostatic process|spermatid differentiation|cellular homeostasis|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|transmembrane transport|gamete generation|excretion|cell projection membrane|cellular developmental process|integral component of membrane|cellular biosynthetic process|response to organic substance|germ cell development|regulation of cellular metabolic process|regulation of gene expression|spermatid development|cellular macromolecule biosynthetic process|male gamete generation|response to purine-containing compound|membrane hyperpolarization|chemical homeostasis|regulation of RNA metabolic process|brush border membrane|response to organophosphorus|cellular response to organonitrogen compound|channel activity|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|response to cAMP|response to organic cyclic compound|gene expression|cellular response to organic substance|macromolecule biosynthetic process|cell differentiation|cell maturation|RNA metabolic process|sulfate transmembrane transporter activity|ion transmembrane transport|spermatogenesis|anion transport|organic anion transport|ion channel activity|anion transmembrane transport|RNA biosynthetic process|antiporter activity|anion transmembrane transporter activity|regulation of RNA biosynthetic process|sulfate transport|cellular response to organic cyclic compound|carboxylic acid transport|carboxylic acid transmembrane transporter activity|ion homeostasis|secondary active sulfate transmembrane transporter activity|cellular response to cAMP|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular ion homeostasis|sulfate transmembrane transport|anion channel activity|dicarboxylic acid transport|regulation of nucleic acid-templated transcription|anion:anion antiporter activity|organic anion transmembrane transporter activity|bicarbonate transport|inorganic anion transport|cellular cation homeostasis|dicarboxylic acid transmembrane transporter activity|chloride channel activity|bicarbonate transmembrane transporter activity|chloride transmembrane transport|chloride transport|oxalate transport|oxalate transmembrane transporter activity|chloride transmembrane transporter activity|regulation of pH|regulation of cellular pH|regulation of intracellular pH|intracellular pH elevation K14078 solute carrier family 26 (chloride anion exchanger), member 3[-] hsa04972|hsa04978 Pancreatic secretion - Homo sapiens (human)|Mineral absorption - Homo sapiens (human) 7:107765467-107803225 5 8 4 0 1 1 0.0780796788554689 0.113531659300785 0.0563161607034998 0 0.0128174895329696 0.0146326148736685 0.0826424996199179 0.0091500348022127 3.1750347550577 0.00131673049307968 0.00752050356617577 UP ENSG00000152642 GPD1L glycerol-3-phosphate dehydrogenase 1-like [Source:HGNC Symbol;Acc:HGNC:28956] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0016491|GO:0050794|GO:0006807|GO:0051050|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0048037|GO:0071944|GO:0023057|GO:0009058|GO:0016247|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0042802|GO:0060341|GO:0044255|GO:0042391|GO:0006725|GO:0044325|GO:0006810|GO:1901360|GO:0034641|GO:0044281|GO:0043270|GO:0031982|GO:0019637|GO:0046483|GO:0016614|GO:0005737|GO:0003012|GO:0003254|GO:0032880|GO:0005975|GO:0006928|GO:0042592|GO:2000010|GO:0009966|GO:0046983|GO:0051186|GO:0010646|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0009331|GO:0055085|GO:0006629|GO:0007165|GO:0009968|GO:0070062|GO:2000021|GO:0050662|GO:0017080|GO:0000166|GO:0002027|GO:0030029|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0003013|GO:0055114|GO:0032268|GO:0005829|GO:0006936|GO:0008654|GO:0046486|GO:0051899|GO:0043412|GO:0048878|GO:0030048|GO:0001508|GO:0036211|GO:0032269|GO:0006811|GO:0006638|GO:0016616|GO:0034765|GO:0043269|GO:0034613|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010765|GO:0008610|GO:1902532|GO:0051246|GO:1903827|GO:1902531|GO:0008015|GO:0046434|GO:0042803|GO:0051287|GO:0006644|GO:0022898|GO:0060373|GO:0034220|GO:0006941|GO:0008016|GO:0090038|GO:2000008|GO:0090036|GO:0098655|GO:0070252|GO:0086001|GO:0046474|GO:0009117|GO:0060047|GO:0006812|GO:0016310|GO:0034394|GO:0032412|GO:0006072|GO:0070528|GO:0050801|GO:0046168|GO:0006639|GO:0006464|GO:0004367|GO:0006650|GO:0086003|GO:0006654|GO:0006468|GO:0086002|GO:0060048|GO:0042325|GO:0046473|GO:0001932|GO:0018193|GO:0042326|GO:0002028|GO:1902305|GO:0030001|GO:2000649|GO:0001933|GO:0015672|GO:0006641|GO:0019432|GO:0033137|GO:0035725|GO:0019674|GO:0006814|GO:0018105|GO:0033135|GO:0086005|GO:0006734 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|cofactor binding|cell periphery|negative regulation of signaling|biosynthetic process|channel regulator activity|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|regulation of metabolic process|identical protein binding|regulation of cellular localization|cellular lipid metabolic process|regulation of membrane potential|cellular aromatic compound metabolic process|ion channel binding|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|positive regulation of ion transport|vesicle|organophosphate metabolic process|heterocycle metabolic process|oxidoreductase activity, acting on CH-OH group of donors|cytoplasm|muscle system process|regulation of membrane depolarization|regulation of protein localization|carbohydrate metabolic process|movement of cell or subcellular component|homeostatic process|positive regulation of protein localization to cell surface|regulation of signal transduction|protein dimerization activity|cofactor metabolic process|regulation of cell communication|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|glycerol-3-phosphate dehydrogenase complex|transmembrane transport|lipid metabolic process|signal transduction|negative regulation of signal transduction|extracellular exosome|regulation of ion homeostasis|coenzyme binding|sodium channel regulator activity|nucleotide binding|regulation of heart rate|actin filament-based process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|oxidation-reduction process|regulation of cellular protein metabolic process|cytosol|muscle contraction|phospholipid biosynthetic process|glycerolipid metabolic process|membrane depolarization|macromolecule modification|chemical homeostasis|actin filament-based movement|action potential|protein modification process|negative regulation of cellular protein metabolic process|ion transport|neutral lipid metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|regulation of ion transmembrane transport|regulation of ion transport|cellular protein localization|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|positive regulation of sodium ion transport|lipid biosynthetic process|negative regulation of intracellular signal transduction|regulation of protein metabolic process|regulation of cellular protein localization|regulation of intracellular signal transduction|blood circulation|organophosphate catabolic process|protein homodimerization activity|NAD binding|phospholipid metabolic process|regulation of transmembrane transporter activity|regulation of ventricular cardiac muscle cell membrane depolarization|ion transmembrane transport|striated muscle contraction|regulation of heart contraction|negative regulation of protein kinase C signaling|regulation of protein localization to cell surface|regulation of protein kinase C signaling|cation transmembrane transport|actin-mediated cell contraction|cardiac muscle cell action potential|glycerophospholipid biosynthetic process|nucleotide metabolic process|heart contraction|cation transport|phosphorylation|protein localization to cell surface|regulation of ion transmembrane transporter activity|glycerol-3-phosphate metabolic process|protein kinase C signaling|ion homeostasis|glycerol-3-phosphate catabolic process|acylglycerol metabolic process|cellular protein modification process|glycerol-3-phosphate dehydrogenase [NAD+] activity|glycerophospholipid metabolic process|cardiac muscle cell contraction|phosphatidic acid biosynthetic process|protein phosphorylation|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|regulation of phosphorylation|phosphatidic acid metabolic process|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|regulation of sodium ion transport|regulation of sodium ion transmembrane transport|metal ion transport|regulation of sodium ion transmembrane transporter activity|negative regulation of protein phosphorylation|monovalent inorganic cation transport|triglyceride metabolic process|triglyceride biosynthetic process|negative regulation of peptidyl-serine phosphorylation|sodium ion transmembrane transport|NAD metabolic process|sodium ion transport|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|ventricular cardiac muscle cell action potential|NADH metabolic process K00006 glycerol-3-phosphate dehydrogenase (NAD+)[1.1.1.8] hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) 3:32105689-32168713 166 191 518 505 558 1136 1.31067100535624 1.37056648306286 3.68748333582978 3.5725273597447 3.61483131454133 8.40607835624976 2.12290694141629 5.19781234351193 -1.29186341772636 0.001317217814383 0.00752151574289531 DOWN ENSG00000137841 PLCB2 phospholipase C beta 2 [Source:HGNC Symbol;Acc:HGNC:9055] GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0009893|GO:0016787|GO:0005622|GO:0005515|GO:0019222|GO:0044255|GO:0043647|GO:0050877|GO:0016788|GO:0044281|GO:0019637|GO:0043169|GO:0005737|GO:0007267|GO:0043085|GO:0007154|GO:0006629|GO:0007165|GO:0050790|GO:0005829|GO:0046872|GO:0051345|GO:0016042|GO:0006066|GO:0007600|GO:0016298|GO:0006796|GO:0035556|GO:0042578|GO:0006644|GO:0004620|GO:0008081|GO:0005509|GO:0007606|GO:0060193|GO:0004629|GO:0050909|GO:0010517|GO:0010518|GO:0007268|GO:0010863|GO:0004435|GO:0050913|GO:0007202 signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|positive regulation of metabolic process|hydrolase activity|intracellular|protein binding|regulation of metabolic process|cellular lipid metabolic process|inositol phosphate metabolic process|neurological system process|hydrolase activity, acting on ester bonds|small molecule metabolic process|organophosphate metabolic process|cation binding|cytoplasm|cell-cell signaling|positive regulation of catalytic activity|cell communication|lipid metabolic process|signal transduction|regulation of catalytic activity|cytosol|metal ion binding|positive regulation of hydrolase activity|lipid catabolic process|alcohol metabolic process|sensory perception|lipase activity|phosphate-containing compound metabolic process|intracellular signal transduction|phosphoric ester hydrolase activity|phospholipid metabolic process|phospholipase activity|phosphoric diester hydrolase activity|calcium ion binding|sensory perception of chemical stimulus|positive regulation of lipase activity|phospholipase C activity|sensory perception of taste|regulation of phospholipase activity|positive regulation of phospholipase activity|synaptic transmission|positive regulation of phospholipase C activity|phosphatidylinositol phospholipase C activity|sensory perception of bitter taste|activation of phospholipase C activity K05858 phosphatidylinositol phospholipase C, beta[3.1.4.11] hsa01100|hsa05200|hsa04015|hsa05016|hsa04062|hsa04020|hsa05010|hsa04022|hsa04921|hsa04261|hsa04072|hsa04310|hsa04728|hsa04611|hsa04270|hsa04071|hsa04919|hsa04724|hsa04726|hsa04725|hsa05142|hsa04933|hsa04922|hsa04723|hsa04916|hsa04915|hsa04750|hsa04070|hsa05146|hsa04972|hsa04713|hsa04912|hsa04970|hsa04540|hsa04911|hsa04742|hsa04925|hsa04971|hsa00562|hsa04918|hsa04720|hsa04924|hsa04730|hsa04961|hsa04973|hsa05143 Metabolic pathways - Homo sapiens (human)|Pathways in cancer - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Phospholipase D signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Thyroid hormone signaling pathway - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Insulin secretion - Homo sapiens (human)|Taste transduction - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Renin secretion - Homo sapiens (human)|Long-term depression - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)|Carbohydrate digestion and absorption - Homo sapiens (human)|African trypanosomiasis - Homo sapiens (human) 15:40278176-40307935 46 57 44 20 32 24 0.234801300152503 0.264425360309195 0.202494410412877 0.0914672343718176 0.134017144163242 0.114812342280014 0.233907023624858 0.113432240271691 1.04410443427736 0.0013379558409669 0.00763151197482345 UP ENSG00000159713 TPPP3 tubulin polymerization-promoting protein family member 3 [Source:HGNC Symbol;Acc:HGNC:24162] GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0043229|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0005874|GO:0031982|GO:0022607|GO:0005737|GO:0070062|GO:0008092|GO:0007017|GO:0006996|GO:0015631|GO:0007010|GO:0006461|GO:0000226|GO:0005856|GO:0034622|GO:0043623|GO:0015630|GO:0031109|GO:0001578|GO:0051258|GO:0046785 cell|cellular process|extracellular region|binding|extracellular vesicle|intracellular organelle|cellular component organization|membrane-bounded organelle|intracellular|protein binding|microtubule|vesicle|cellular component assembly|cytoplasm|extracellular exosome|cytoskeletal protein binding|microtubule-based process|organelle organization|tubulin binding|cytoskeleton organization|protein complex assembly|microtubule cytoskeleton organization|cytoskeleton|cellular macromolecular complex assembly|cellular protein complex assembly|microtubule cytoskeleton|microtubule polymerization or depolymerization|microtubule bundle formation|protein polymerization|microtubule polymerization - - - - 16:67389809-67393535 1 0 3 6 6 16 0.0135802520480932 0 0.0367109540996491 0.0729773777856473 0.066821147852488 0.20355266926584 0.0167637353825808 0.114450398301325 -2.77130692488421 0.00134898860172329 0.00768856542876041 DOWN ENSG00000224209 LINC00466 long intergenic non-protein coding RNA 466 [Source:HGNC Symbol;Acc:HGNC:27294] - - - - - - 1:63159087-63317274 0 0 0 4 5 2 0 0 0 0.0390757414345467 0.044728713813794 0.0204333370461523 0 0.034745930764831 -Inf 0.0013531115347243 0.00770764963893518 DOWN ENSG00000182901 RGS7 regulator of G-protein signaling 7 [Source:HGNC Symbol;Acc:HGNC:10003] GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0019898|GO:0048523|GO:0050794|GO:0023051|GO:0071944|GO:0023057|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0009898|GO:0098797|GO:0008047|GO:0005737|GO:0031234|GO:0098562|GO:0009966|GO:0019897|GO:0010646|GO:0043085|GO:0007154|GO:0031681|GO:0007165|GO:0009968|GO:0005834|GO:0050790|GO:0007186|GO:0005096|GO:0051345|GO:0030695|GO:0035556|GO:0043087|GO:0043547 macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|extrinsic component of membrane|negative regulation of cellular process|regulation of cellular process|regulation of signaling|cell periphery|negative regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|plasma membrane|protein complex|regulation of metabolic process|cytoplasmic side of plasma membrane|plasma membrane protein complex|enzyme activator activity|cytoplasm|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|regulation of signal transduction|extrinsic component of plasma membrane|regulation of cell communication|positive regulation of catalytic activity|cell communication|G-protein beta-subunit binding|signal transduction|negative regulation of signal transduction|heterotrimeric G-protein complex|regulation of catalytic activity|G-protein coupled receptor signaling pathway|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity - - - - 1:240775514-241357230 35 35 57 107 107 71 0.664280680066843 0.6037257841227 0.975382034151345 1.81956716264802 1.66624410235438 1.26290637397939 0.747796166113629 1.5829058796606 -1.08185849493459 0.00135545748535498 0.00771953982598006 DOWN ENSG00000204866 IGFL2 IGF like family member 2 [Source:HGNC Symbol;Acc:HGNC:32929] GO:0005576 extracellular region - - - - 19:46143106-46161299 1 5 5 12 10 26 0.0196410473001981 0.089222019165478 0.0884976091608933 0.211093597358317 0.161087924076545 0.47839048850177 0.0657868918755231 0.283524003312211 -2.10759882093682 0.0013569251307995 0.00772495096393752 DOWN ENSG00000224261 RPSAP18 ribosomal protein SA pseudogene 18 [Source:HGNC Symbol;Acc:HGNC:36106] - - - - - - 1:160266340-160267225 12 13 7 2 3 4 0.958091440549524 0.943301751338344 0.503852132957252 0.143071902047031 0.196536751020456 0.299258444143197 0.80174844161504 0.212955699070228 1.91259630498604 0.00135724694179171 0.00772530985705427 UP ENSG00000225721 RP11-269F19.2 - - - - - - - 1:44759037-44775810 15 13 14 3 4 7 1.07828920192777 0.849355032200989 0.907411308896331 0.193201726335855 0.235911247601162 0.471616599994338 0.945018514341697 0.300243191310452 1.65421106424051 0.0013603819188848 0.00774020236447245 UP ENSG00000231609 AC009501.4 - - - - - - - 2:63043922-63048640 8 15 17 37 35 33 0.165313614836494 0.28172362133915 0.31673780595012 0.685070221774705 0.593438838801734 0.639121140656238 0.254591680708588 0.639210067077559 -1.32810485273713 0.00136413015001081 0.007758571441879 DOWN ENSG00000247708 STX18-AS1 STX18 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:48877] - - - - - - 4:4542131-4710938 6 9 8 22 22 24 0.0536469950308419 0.0731407083010359 0.0644955651591086 0.176250112392658 0.16140411006388 0.201121152738774 0.0637610894969955 0.179591791731771 -1.49397322676853 0.00136408054243819 0.007758571441879 DOWN ENSG00000136098 NEK3 NIMA-related kinase 3 [Source:HGNC Symbol;Acc:HGNC:7746] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0048856|GO:0019222|GO:0007049|GO:0048468|GO:0022402|GO:0007275|GO:0043168|GO:0001882|GO:0016772|GO:0043231|GO:0043169|GO:0005737|GO:0043005|GO:0007163|GO:0007059|GO:0000166|GO:0030030|GO:0051301|GO:0048869|GO:0007017|GO:0019538|GO:0031323|GO:0006996|GO:0032268|GO:0000902|GO:0031175|GO:0005813|GO:0046872|GO:0035639|GO:1903047|GO:0030424|GO:0043412|GO:0005815|GO:0001883|GO:0036211|GO:0000278|GO:0032549|GO:0030010|GO:0016301|GO:0006796|GO:0044267|GO:0007067|GO:0032990|GO:0007399|GO:0017076|GO:0051246|GO:0030154|GO:0048858|GO:0016773|GO:0005856|GO:0005634|GO:0048666|GO:0030182|GO:0005524|GO:0030554|GO:0016310|GO:0015630|GO:0004672|GO:0022008|GO:0006464|GO:0048812|GO:0006468|GO:0048699|GO:0090311|GO:0004674|GO:0090043|GO:0006476|GO:0090042 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|protein binding|transferase activity|anatomical structure development|regulation of metabolic process|cell cycle|cell development|cell cycle process|multicellular organism development|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|intracellular membrane-bounded organelle|cation binding|cytoplasm|neuron projection|establishment or maintenance of cell polarity|chromosome segregation|nucleotide binding|cell projection organization|cell division|cellular developmental process|microtubule-based process|protein metabolic process|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|centrosome|metal ion binding|purine ribonucleoside triphosphate binding|mitotic cell cycle process|axon|macromolecule modification|microtubule organizing center|purine nucleoside binding|protein modification process|mitotic cell cycle|ribonucleoside binding|establishment of cell polarity|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|mitotic nuclear division|cell part morphogenesis|nervous system development|purine nucleotide binding|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|phosphotransferase activity, alcohol group as acceptor|cytoskeleton|nucleus|neuron development|neuron differentiation|ATP binding|adenyl nucleotide binding|phosphorylation|microtubule cytoskeleton|protein kinase activity|neurogenesis|cellular protein modification process|neuron projection morphogenesis|protein phosphorylation|generation of neurons|regulation of protein deacetylation|protein serine/threonine kinase activity|regulation of tubulin deacetylation|protein deacetylation|tubulin deacetylation - - - - 13:52132639-52159861 8 11 2 0 0 2 0.0739987581516046 0.0924795014420863 0.0166805419110013 0 0 0.0173364052249818 0.0610529338348974 0.0057788017416606 3.40121834398901 0.00136498605813896 0.00776196071993915 UP ENSG00000280537 RP11-33O4.2 - - - - - - - 2:219075329-219170827 0 4 0 7 3 45 0 0.0458458207017789 0 0.0790932268036763 0.0310450278844935 0.531861495052473 0.0152819402339263 0.213999916580214 -3.80771060590655 0.00136958680668318 0.00778225255862525 DOWN ENSG00000175567 UCP2 uncoupling protein 2 (mitochondrial, proton carrier) [Source:HGNC Symbol;Acc:HGNC:12518] GO:0032502|GO:0000003|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0003735|GO:0043227|GO:0009605|GO:0023057|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0048856|GO:0031090|GO:0060341|GO:0061179|GO:0042391|GO:0019866|GO:0006810|GO:0010941|GO:0061178|GO:0009991|GO:0007275|GO:0048513|GO:0034641|GO:0015980|GO:0044281|GO:0032940|GO:0033554|GO:0010942|GO:0043231|GO:0010243|GO:0005737|GO:0007267|GO:0031668|GO:0032880|GO:0042592|GO:0031966|GO:0045184|GO:0046883|GO:0019725|GO:0006979|GO:0060548|GO:0010646|GO:0008104|GO:0007154|GO:0007565|GO:0051649|GO:0046888|GO:0009725|GO:0008219|GO:0001666|GO:0051048|GO:1903531|GO:0006091|GO:0010817|GO:0016021|GO:0022900|GO:0010035|GO:0044249|GO:0019538|GO:0010033|GO:0051224|GO:0048732|GO:0042594|GO:0055114|GO:0007568|GO:0005740|GO:0009743|GO:0034645|GO:0006518|GO:0090276|GO:0033993|GO:0043069|GO:0048878|GO:0031100|GO:0050709|GO:0051223|GO:0015031|GO:1901652|GO:0001889|GO:0071417|GO:0070201|GO:0046907|GO:0042886|GO:0022904|GO:0006811|GO:0055082|GO:0051046|GO:0005743|GO:0043434|GO:0009914|GO:0009306|GO:0005739|GO:0009267|GO:0051881|GO:0070542|GO:0035773|GO:0012501|GO:0000302|GO:0043603|GO:0002792|GO:0044267|GO:0000305|GO:0010467|GO:0046903|GO:0071310|GO:0045333|GO:0009059|GO:0031669|GO:0031667|GO:0032870|GO:0043067|GO:0050796|GO:0071322|GO:0002790|GO:0030073|GO:0043043|GO:0097421|GO:0001678|GO:1901653|GO:0046676|GO:0015992|GO:0006839|GO:0006812|GO:0034284|GO:0050708|GO:0015833|GO:0006412|GO:0071375|GO:0042981|GO:0034198|GO:0043066|GO:0032868|GO:0046879|GO:0006915|GO:0033500|GO:0000303|GO:0071333|GO:0042593|GO:0030072|GO:0032869|GO:0015672|GO:0009749 developmental process|reproduction|structural molecule activity|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|structural constituent of ribosome|membrane-bounded organelle|response to external stimulus|negative regulation of signaling|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|anatomical structure development|organelle membrane|regulation of cellular localization|negative regulation of insulin secretion involved in cellular response to glucose stimulus|regulation of membrane potential|organelle inner membrane|transport|regulation of cell death|regulation of insulin secretion involved in cellular response to glucose stimulus|response to extracellular stimulus|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|cellular response to stress|positive regulation of cell death|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|cell-cell signaling|cellular response to extracellular stimulus|regulation of protein localization|homeostatic process|mitochondrial membrane|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|response to oxidative stress|negative regulation of cell death|regulation of cell communication|protein localization|cell communication|female pregnancy|establishment of localization in cell|negative regulation of hormone secretion|response to hormone|cell death|response to hypoxia|negative regulation of secretion|negative regulation of secretion by cell|generation of precursor metabolites and energy|regulation of hormone levels|integral component of membrane|electron transport chain|response to inorganic substance|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of protein transport|gland development|response to starvation|oxidation-reduction process|aging|mitochondrial envelope|response to carbohydrate|cellular macromolecule biosynthetic process|peptide metabolic process|regulation of peptide hormone secretion|response to lipid|negative regulation of programmed cell death|chemical homeostasis|organ regeneration|negative regulation of protein secretion|regulation of protein transport|protein transport|response to peptide|liver development|cellular response to organonitrogen compound|regulation of establishment of protein localization|intracellular transport|amide transport|respiratory electron transport chain|ion transport|cellular chemical homeostasis|regulation of secretion|mitochondrial inner membrane|response to peptide hormone|hormone transport|protein secretion|mitochondrion|cellular response to starvation|regulation of mitochondrial membrane potential|response to fatty acid|insulin secretion involved in cellular response to glucose stimulus|programmed cell death|response to reactive oxygen species|cellular amide metabolic process|negative regulation of peptide secretion|cellular protein metabolic process|response to oxygen radical|gene expression|secretion|cellular response to organic substance|cellular respiration|macromolecule biosynthetic process|cellular response to nutrient levels|response to nutrient levels|cellular response to hormone stimulus|regulation of programmed cell death|regulation of insulin secretion|cellular response to carbohydrate stimulus|peptide secretion|insulin secretion|peptide biosynthetic process|liver regeneration|cellular glucose homeostasis|cellular response to peptide|negative regulation of insulin secretion|proton transport|mitochondrial transport|cation transport|response to monosaccharide|regulation of protein secretion|peptide transport|translation|cellular response to peptide hormone stimulus|regulation of apoptotic process|cellular response to amino acid starvation|negative regulation of apoptotic process|response to insulin|hormone secretion|apoptotic process|carbohydrate homeostasis|response to superoxide|cellular response to glucose stimulus|glucose homeostasis|peptide hormone secretion|cellular response to insulin stimulus|monovalent inorganic cation transport|response to glucose - - - - 11:73974667-73983307 197 213 321 385 405 775 2.50451858012276 2.46103985756644 3.6794130262926 4.38548288569029 4.22455714155274 9.23398089360498 2.8816571546606 5.948006973616 -1.04550763785861 0.00137333950202524 0.00780203187316111 DOWN ENSG00000214357 NEURL1B neuralized E3 ubiquitin protein ligase 1B [Source:HGNC Symbol;Acc:HGNC:35422] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0012505|GO:0006810|GO:0043231|GO:0043169|GO:0005737|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0019538|GO:0005768|GO:0016192|GO:0046872|GO:0007166|GO:0043412|GO:0005769|GO:0070086|GO:0015031|GO:0036211|GO:0044267|GO:0046914|GO:0006897|GO:0007219|GO:0006464|GO:0008270|GO:0032446|GO:0016567 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|ligase activity|intracellular|protein binding|endomembrane system|transport|intracellular membrane-bounded organelle|cation binding|cytoplasm|establishment of protein localization|protein localization|cell communication|signal transduction|protein metabolic process|endosome|vesicle-mediated transport|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|early endosome|ubiquitin-dependent endocytosis|protein transport|protein modification process|cellular protein metabolic process|transition metal ion binding|endocytosis|Notch signaling pathway|cellular protein modification process|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 5:172641266-172691540 127 199 511 583 567 849 1.34706750496098 1.91830912256601 4.88675216912564 5.5405288296071 4.93442321655242 8.43959356735985 2.71737626555088 6.30484853783979 -1.21424736861887 0.00137900994393115 0.00782977612516556 DOWN ENSG00000059804 SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 [Source:HGNC Symbol;Acc:HGNC:11007] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0036094|GO:1903561|GO:0022857|GO:0071704|GO:0044237|GO:0030246|GO:0043227|GO:0071944|GO:0031224|GO:0005886|GO:0048029|GO:0006810|GO:0006082|GO:0044281|GO:0031982|GO:0005887|GO:0005975|GO:0022891|GO:0031226|GO:0055085|GO:0070062|GO:0016021|GO:0005536|GO:0051119|GO:0005996|GO:0034219|GO:0008643|GO:0006766|GO:0035428|GO:0019752|GO:0019852|GO:0006767|GO:0015149|GO:0008645|GO:1904659|GO:0005355|GO:0015758 transporter activity|cell|membrane|cellular process|extracellular region|metabolic process|binding|small molecule binding|extracellular vesicle|transmembrane transporter activity|organic substance metabolic process|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|cell periphery|intrinsic component of membrane|plasma membrane|monosaccharide binding|transport|organic acid metabolic process|small molecule metabolic process|vesicle|integral component of plasma membrane|carbohydrate metabolic process|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|extracellular exosome|integral component of membrane|glucose binding|sugar transmembrane transporter activity|monosaccharide metabolic process|carbohydrate transmembrane transport|carbohydrate transport|vitamin metabolic process|hexose transmembrane transport|carboxylic acid metabolic process|L-ascorbic acid metabolic process|water-soluble vitamin metabolic process|hexose transmembrane transporter activity|hexose transport|glucose transmembrane transport|glucose transmembrane transporter activity|glucose transport - - - - 12:7919230-7936275 31 25 528 9 25 46 0.164999235727349 0.120934008776118 2.53378056626532 0.0429191583412709 0.109175421728408 0.229458003847031 0.939904603589596 0.127184194638903 2.88559494067788 0.00139078655863532 0.00789063890564403 UP ENSG00000240204 SMKR1 small lysine-rich protein 1 [Source:HGNC Symbol;Acc:HGNC:43561] - - - - - - 7:129502479-129512932 97 135 100 57 83 35 4.70284700496371 5.94846895499126 4.37126230497867 2.47608802006272 3.30168301640826 1.590324301043 5.00752608831121 2.45603177917133 1.02776880404109 0.00139148913154126 0.00789195298428388 UP ENSG00000271998 CTD-2199O4.7 - - - - - - - 5:10195187-10197622 4 1 3 11 15 11 0.11614706559633 0.0264030076916828 0.0785306986097174 0.286189375849409 0.357389033526965 0.299348816053079 0.0736935906325767 0.314309075143151 -2.09257287403389 0.00139154687845081 0.00789195298428388 DOWN ENSG00000260170 RP11-96O20.4 - GO:0008152|GO:0003824|GO:0016491|GO:0055114 metabolic process|catalytic activity|oxidoreductase activity|oxidation-reduction process - - - - 15:45587351-45676314 26 27 54 73 99 74 1.73503669585018 1.63753545357806 3.24900760327244 4.3647565516687 5.42052859702525 4.62809415915543 2.20719325090023 4.80445976928313 -1.12216126793123 0.00139242504477859 0.00789543348277681 DOWN ENSG00000272414 FAM47E-STBD1 FAM47E-STBD1 readthrough [Source:HGNC Symbol;Acc:HGNC:44667] - - - - - - 4:76251721-76311129 10 20 20 36 41 50 0.0921730035811377 0.16754574427696 0.166218535305482 0.297321680431848 0.310078987057291 0.431940366091779 0.14197909438786 0.346447011193639 -1.28695619337968 0.00139877731614133 0.00792994644817379 DOWN ENSG00000188107 EYS eyes shut homolog (Drosophila) [Source:HGNC Symbol;Acc:HGNC:21555] GO:0032502|GO:0040007|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051606|GO:0006950|GO:0043167|GO:0009628|GO:0043227|GO:0009605|GO:0048589|GO:0005515|GO:0048856|GO:0009888|GO:0009314|GO:0050877|GO:0031982|GO:0042246|GO:0009582|GO:0043169|GO:0009611|GO:0050906|GO:0070062|GO:0046872|GO:0009583|GO:0042060|GO:0007600|GO:0043403|GO:0009416|GO:0050953|GO:0050908|GO:0005509|GO:0009584|GO:0007601 developmental process|growth|extracellular region|response to stimulus|binding|extracellular vesicle|detection of stimulus|response to stress|ion binding|response to abiotic stimulus|membrane-bounded organelle|response to external stimulus|developmental growth|protein binding|anatomical structure development|tissue development|response to radiation|neurological system process|vesicle|tissue regeneration|detection of abiotic stimulus|cation binding|response to wounding|detection of stimulus involved in sensory perception|extracellular exosome|metal ion binding|detection of light stimulus|wound healing|sensory perception|skeletal muscle tissue regeneration|response to light stimulus|sensory perception of light stimulus|detection of light stimulus involved in visual perception|calcium ion binding|detection of visible light|visual perception - - - - 6:63719980-65707225 3 4 6 14 11 29 0.00922394799074032 0.0111760271335685 0.0166312448163884 0.0385645589332733 0.0277458775558786 0.0835541816769538 0.0123437399802324 0.0499548727220352 -2.01684583182895 0.00140107975910869 0.0079414913856903 DOWN ENSG00000154114 TBCEL tubulin folding cofactor E-like [Source:HGNC Symbol;Acc:HGNC:28115] GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0005737|GO:0005856 cell|binding|intracellular organelle|intracellular|protein binding|cytoplasm|cytoskeleton - - - - 11:121024072-121090775 25 80 84 165 172 127 0.125181458563564 0.364053526320207 0.379218720961029 0.74024832094298 0.706630860387029 0.595975608000724 0.289484568614933 0.680951596443578 -1.23406580654347 0.0014114101710045 0.00799549131786873 DOWN ENSG00000271401 RP11-171I2.3 - - - - - - - 2:178644717-178645179 0 0 0 3 6 3 0 0 0 0.410605828756979 0.752062638141069 0.429497270265992 0 0.530721912388013 -Inf 0.0014138935097275 0.00800652064480364 DOWN ENSG00000279459 RP11-826F13.1 - - - - - - - 11:70603304-70604859 0 0 0 5 4 2 0 0 0 0.203645375275161 0.149188089742637 0.0852001868608202 0 0.146011217292873 -Inf 0.00141701906141944 0.00801965631461914 DOWN ENSG00000272009 RP1-313I6.12 - - - - - - - 6:28078792-28081130 52 44 38 22 22 24 5.36201757456454 4.12338380682078 3.53279770775711 2.03252862848151 1.86132349083871 2.31934320600064 4.33939969638081 2.07106510844029 1.06712256848111 0.0014217515524243 0.00804339034414916 UP ENSG00000227486 RP13-188A5.1 - - - - - - - X:55908123-56015173 0 1 0 8 4 4 0 0.063870632310764 0 0.503522165694814 0.23052300659339 0.263299882334531 0.0212902107702547 0.332448351540912 -3.96486808656908 0.00142208925519829 0.0080437765488234 DOWN ENSG00000243135 UGT1A3 UDP glucuronosyltransferase 1 family, polypeptide A3 [Source:HGNC Symbol;Acc:HGNC:12535] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0044237|GO:0042445|GO:0043227|GO:0008289|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0042802|GO:0019840|GO:0044262|GO:0044255|GO:0006082|GO:0009410|GO:0043168|GO:0044281|GO:0043231|GO:0019899|GO:0005737|GO:0005975|GO:0043177|GO:0046983|GO:0044092|GO:0009812|GO:0006629|GO:0005783|GO:0016757|GO:0042180|GO:0006805|GO:0050790|GO:0045833|GO:0043086|GO:0010817|GO:0016021|GO:0031324|GO:0031323|GO:0006109|GO:0042573|GO:0046982|GO:0006720|GO:0008194|GO:0006631|GO:0052696|GO:0005501|GO:0052697|GO:0016758|GO:0071466|GO:0005996|GO:0010565|GO:0009813|GO:0031406|GO:0019216|GO:0045922|GO:0042803|GO:0019217|GO:2001030|GO:0015020|GO:1904224|GO:0019752|GO:0001972|GO:0016101|GO:0032787|GO:0052695|GO:0001523 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|lipid binding|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|identical protein binding|isoprenoid binding|cellular carbohydrate metabolic process|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|anion binding|small molecule metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|carbohydrate metabolic process|organic acid binding|protein dimerization activity|negative regulation of molecular function|flavonoid metabolic process|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular ketone metabolic process|xenobiotic metabolic process|regulation of catalytic activity|negative regulation of lipid metabolic process|negative regulation of catalytic activity|regulation of hormone levels|integral component of membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of carbohydrate metabolic process|retinoic acid metabolic process|protein heterodimerization activity|isoprenoid metabolic process|UDP-glycosyltransferase activity|fatty acid metabolic process|flavonoid glucuronidation|retinoid binding|xenobiotic glucuronidation|transferase activity, transferring hexosyl groups|cellular response to xenobiotic stimulus|monosaccharide metabolic process|regulation of cellular ketone metabolic process|flavonoid biosynthetic process|carboxylic acid binding|regulation of lipid metabolic process|negative regulation of fatty acid metabolic process|protein homodimerization activity|regulation of fatty acid metabolic process|negative regulation of cellular glucuronidation|glucuronosyltransferase activity|negative regulation of glucuronosyltransferase activity|carboxylic acid metabolic process|retinoic acid binding|diterpenoid metabolic process|monocarboxylic acid metabolic process|cellular glucuronidation|retinoid metabolic process K00699 glucuronosyltransferase[2.4.1.17] hsa01100|hsa05204|hsa00980|hsa00982|hsa00830|hsa00140|hsa00500|hsa00983|hsa00860|hsa00040|hsa00053 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Ascorbate and aldarate metabolism - Homo sapiens (human) 2:233729108-233773299 37 51 61 42 239 215 1.10712403574681 1.38692167118884 1.64566880256722 1.12602863421109 5.86765012424708 6.0292716476182 1.37990483650096 4.34098346869212 -1.65345315185536 0.00142988480215401 0.00808137670340735 DOWN ENSG00000272275 RP11-791G15.2 - - - - - - - 2:10767875-10770058 14 6 8 2 2 2 2.51993929318883 0.981485527924725 1.2982809566761 0.322548868228166 0.295339271806035 0.337332037545639 1.59990192592989 0.318406725859947 2.32904075447888 0.0014296628642436 0.00808137670340735 UP ENSG00000227252 AC105760.2 - - - - - - - 2:237059434-237085817 3 3 8 11 18 27 0.0906594700209073 0.0823974074733355 0.217951480552631 0.297803212118393 0.446250801250268 0.764599177893889 0.130336119348958 0.502884397087517 -1.94798984620149 0.00144422767460754 0.00815355011303581 DOWN ENSG00000224034 RP11-445P17.8 - - - - - - - 10:5266033-5271236 11 5 2 16 35 22 1.12442532211599 0.464547594007539 0.184329630048305 1.4653605830886 2.93546408268546 2.10765599503035 0.591100848723945 2.16949355360147 -1.87588210218343 0.0014507218680007 0.00818247697851748 DOWN ENSG00000123119 NECAB1 N-terminal EF-hand calcium binding protein 1 [Source:HGNC Symbol;Acc:HGNC:20983] GO:0005623|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0043231|GO:0043169|GO:0005737|GO:0046872|GO:0031981|GO:0005654|GO:0005634|GO:0005509 cell|binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cation binding|cytoplasm|metal ion binding|nuclear lumen|nucleoplasm|nucleus|calcium ion binding - - - - 8:90791550-90959408 8 7 9 1 3 2 0.0579189870609335 0.0460636171147755 0.0587481160484701 0.00648401161727861 0.0178230871447415 0.013569241633105 0.0542435734080597 0.012625446798375 2.10311777824147 0.00146050839444812 0.00823145508926828 UP ENSG00000259976 RP11-553L6.5 - - - - - - - 3:114314501-114316179 30 22 43 73 71 72 1.26389109552939 0.842358931351714 1.63332704784281 2.75559377294153 2.45425098074574 2.84284562310835 1.24652569157464 2.68423012559854 -1.10659574473876 0.00146359211916358 0.00824572166927903 DOWN ENSG00000271590 RP11-181E10.3 - - - - - - - 2:111210995-111212476 1 1 0 4 5 11 0.0477508052784169 0.0433992758009038 0 0.171068428088623 0.195816393538391 0.492047041771458 0.0303833603597736 0.286310621132824 -3.23622784636667 0.00146489851496782 0.00824996798072993 DOWN ENSG00000180881 CAPS2 calcyphosine 2 [Source:HGNC Symbol;Acc:HGNC:16471] GO:0005488|GO:0043167|GO:0043169|GO:0046872|GO:0005509 binding|ion binding|cation binding|metal ion binding|calcium ion binding - - - - 12:75275979-75390928 9 14 33 39 60 53 0.0569288381478972 0.0804812866947127 0.18820015574664 0.221028084981533 0.31139072699534 0.31418828628467 0.108536760196417 0.282202366087181 -1.37854633382797 0.00147849371241987 0.0083124202053828 DOWN ENSG00000259172 RP11-299G20.2 - - - - - - - 15:101295419-101305737 7 17 3 40 35 22 0.191184583440774 0.421974733591525 0.0738613057194099 0.978830110448395 0.7843016004704 0.563126621066025 0.22900687425057 0.77541944399494 -1.7595860064745 0.00148976817083451 0.00836635420844498 DOWN ENSG00000267475 CTD-2538C1.2 - - - - - - - 19:32687089-32691750 16 23 12 9 4 4 1.9926113875344 2.60323657126139 1.34742363373338 1.00421763090755 0.408691316266801 0.466801023786747 1.98109053084306 0.626569990320366 1.66074723091609 0.00149191570418149 0.00837683871217493 UP ENSG00000197140 ADAM32 ADAM metallopeptidase domain 32 [Source:HGNC Symbol;Acc:HGNC:15479] GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0043167|GO:0016787|GO:0031224|GO:0005515|GO:0043169|GO:0008233|GO:0016021|GO:0019538|GO:0046872|GO:0006508|GO:0008237|GO:0004175|GO:0046914|GO:0008270|GO:0004222 membrane|metabolic process|binding|catalytic activity|organic substance metabolic process|ion binding|hydrolase activity|intrinsic component of membrane|protein binding|cation binding|peptidase activity|integral component of membrane|protein metabolic process|metal ion binding|proteolysis|metallopeptidase activity|endopeptidase activity|transition metal ion binding|zinc ion binding|metalloendopeptidase activity - - - - 8:39106990-39284911 20 11 10 40 37 40 0.119872692756499 0.0599212631357087 0.054040037279032 0.214808505851664 0.181953014661761 0.224689239015483 0.0779446643904132 0.207150253176303 -1.4101554101238 0.00149826847589931 0.00840934519261104 DOWN ENSG00000149596 JPH2 junctophilin 2 [Source:HGNC Symbol;Acc:HGNC:14202] GO:0032502|GO:0032991|GO:0004871|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0004872|GO:0022857|GO:0048523|GO:0050794|GO:0043229|GO:0051050|GO:0005057|GO:0042175|GO:0043167|GO:0051641|GO:0038023|GO:0023051|GO:0072341|GO:0043227|GO:0008289|GO:0071944|GO:0031224|GO:0050793|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0030017|GO:0007507|GO:0060341|GO:0030018|GO:0051282|GO:0009888|GO:0006810|GO:0033017|GO:0007275|GO:0010524|GO:0048513|GO:0043168|GO:0005543|GO:0043270|GO:0015278|GO:0061061|GO:0043231|GO:0004888|GO:0005737|GO:0042592|GO:0043177|GO:0009966|GO:0019725|GO:0030314|GO:0022891|GO:0031674|GO:0032388|GO:0010646|GO:0001786|GO:0007154|GO:0055085|GO:0007165|GO:0005783|GO:0051649|GO:2000021|GO:0051238|GO:0016021|GO:0009967|GO:0010469|GO:0032411|GO:0014701|GO:1902533|GO:0005829|GO:0016528|GO:0072358|GO:0048878|GO:0035091|GO:0032386|GO:0048738|GO:0051208|GO:0034767|GO:0060537|GO:0015267|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0015075|GO:0051279|GO:0043292|GO:0034765|GO:0043269|GO:0035556|GO:0031406|GO:0051281|GO:0032414|GO:0070300|GO:0010522|GO:0007517|GO:1902531|GO:0051928|GO:0072359|GO:0060314|GO:0016529|GO:0022898|GO:2000273|GO:0034220|GO:0016202|GO:0050850|GO:0015276|GO:0055024|GO:0098655|GO:0005216|GO:0030016|GO:0090280|GO:0006812|GO:1901021|GO:0060402|GO:0016482|GO:0032412|GO:1901981|GO:2001259|GO:0050801|GO:0016597|GO:1904427|GO:0014706|GO:0019932|GO:0050848|GO:0060316|GO:0006873|GO:0090279|GO:0008324|GO:1903169|GO:1902936|GO:0070273|GO:0032266|GO:0022890|GO:1901019|GO:0030001|GO:0005547|GO:0019722|GO:0010314|GO:0051924|GO:0005261|GO:2001257|GO:0030003|GO:0005262|GO:0070588|GO:0055065|GO:0080025|GO:0097553|GO:0006875|GO:0046873|GO:0005546|GO:0006874|GO:0006816|GO:0055074|GO:0015085|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|macromolecular complex|signal transducer activity|transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|receptor activity|transmembrane transporter activity|negative regulation of cellular process|regulation of cellular process|intracellular organelle|positive regulation of transport|receptor signaling protein activity|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|cellular localization|signaling receptor activity|regulation of signaling|modified amino acid binding|membrane-bounded organelle|lipid binding|cell periphery|intrinsic component of membrane|regulation of developmental process|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|sarcomere|heart development|regulation of cellular localization|Z disc|regulation of sequestering of calcium ion|tissue development|transport|sarcoplasmic reticulum membrane|multicellular organism development|positive regulation of calcium ion transport into cytosol|animal organ development|anion binding|phospholipid binding|positive regulation of ion transport|calcium-release channel activity|muscle structure development|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|homeostatic process|organic acid binding|regulation of signal transduction|cellular homeostasis|junctional membrane complex|substrate-specific transmembrane transporter activity|I band|positive regulation of intracellular transport|regulation of cell communication|phosphatidylserine binding|cell communication|transmembrane transport|signal transduction|endoplasmic reticulum|establishment of localization in cell|regulation of ion homeostasis|sequestering of metal ion|integral component of membrane|positive regulation of signal transduction|regulation of receptor activity|positive regulation of transporter activity|junctional sarcoplasmic reticulum membrane|positive regulation of intracellular signal transduction|cytosol|sarcoplasm|cardiovascular system development|chemical homeostasis|phosphatidylinositol binding|regulation of intracellular transport|cardiac muscle tissue development|sequestering of calcium ion|positive regulation of ion transmembrane transport|muscle tissue development|channel activity|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol|contractile fiber|regulation of ion transmembrane transport|regulation of ion transport|intracellular signal transduction|carboxylic acid binding|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of ion transmembrane transporter activity|phosphatidic acid binding|regulation of calcium ion transport into cytosol|muscle organ development|regulation of intracellular signal transduction|positive regulation of calcium ion transport|circulatory system development|regulation of ryanodine-sensitive calcium-release channel activity|sarcoplasmic reticulum|regulation of transmembrane transporter activity|positive regulation of receptor activity|ion transmembrane transport|regulation of striated muscle tissue development|positive regulation of calcium-mediated signaling|ligand-gated ion channel activity|regulation of cardiac muscle tissue development|cation transmembrane transport|ion channel activity|myofibril|positive regulation of calcium ion import|cation transport|positive regulation of calcium ion transmembrane transporter activity|calcium ion transport into cytosol|cytosolic transport|regulation of ion transmembrane transporter activity|phosphatidylinositol phosphate binding|positive regulation of cation channel activity|ion homeostasis|amino acid binding|positive regulation of calcium ion transmembrane transport|striated muscle tissue development|second-messenger-mediated signaling|regulation of calcium-mediated signaling|positive regulation of ryanodine-sensitive calcium-release channel activity|cellular ion homeostasis|regulation of calcium ion import|cation transmembrane transporter activity|regulation of calcium ion transmembrane transport|phosphatidylinositol bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-3-phosphate binding|inorganic cation transmembrane transporter activity|regulation of calcium ion transmembrane transporter activity|metal ion transport|phosphatidylinositol-3,4,5-trisphosphate binding|calcium-mediated signaling|phosphatidylinositol-5-phosphate binding|regulation of calcium ion transport|cation channel activity|regulation of cation channel activity|cellular cation homeostasis|calcium channel activity|calcium ion transmembrane transport|metal ion homeostasis|phosphatidylinositol-3,5-bisphosphate binding|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|metal ion transmembrane transporter activity|phosphatidylinositol-4,5-bisphosphate binding|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|calcium ion transmembrane transporter activity|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration - - - - 20:44111695-44187578 104 138 306 357 355 508 1.0963668928992 1.3221531575129 2.90842770851929 3.37201594950842 3.07057425127546 5.01898504573844 1.77564925297713 3.82052508217411 -1.10542429999807 0.00150053240847554 0.00842046889523098 DOWN ENSG00000123843 C4BPB complement component 4 binding protein, beta [Source:HGNC Symbol;Acc:HGNC:1328] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0002683|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0044216|GO:0071704|GO:0009056|GO:0006955|GO:0044237|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0005615|GO:0002684|GO:0002682|GO:0005515|GO:0005886|GO:0019222|GO:0002250|GO:0050817|GO:0045087|GO:0006959|GO:0006810|GO:0060627|GO:0006952|GO:0051128|GO:0009611|GO:0006956|GO:0050776|GO:0050778|GO:0050777|GO:0008228|GO:0019538|GO:0031324|GO:0031323|GO:0050878|GO:0002443|GO:0016192|GO:0032268|GO:0006909|GO:0045732|GO:0010468|GO:0006958|GO:0030163|GO:0010629|GO:0050727|GO:0007596|GO:0051604|GO:0032269|GO:0042060|GO:0006954|GO:0007599|GO:0030449|GO:0030100|GO:0051247|GO:0006508|GO:0002820|GO:1903027|GO:0002460|GO:0044267|GO:0042176|GO:0010467|GO:0002819|GO:0051246|GO:0002455|GO:0002920|GO:0045916|GO:0002673|GO:0050764|GO:0016485|GO:0030162|GO:0002526|GO:0002924|GO:0045959|GO:0045861|GO:0019724|GO:0006897|GO:0016064|GO:0010955|GO:0070613 immune system process|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|other organism cell|organic substance metabolic process|catabolic process|immune response|cellular metabolic process|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|extracellular space|positive regulation of immune system process|regulation of immune system process|protein binding|plasma membrane|regulation of metabolic process|adaptive immune response|coagulation|innate immune response|humoral immune response|transport|regulation of vesicle-mediated transport|defense response|regulation of cellular component organization|response to wounding|complement activation|regulation of immune response|positive regulation of immune response|negative regulation of immune response|opsonization|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|leukocyte mediated immunity|vesicle-mediated transport|regulation of cellular protein metabolic process|phagocytosis|positive regulation of protein catabolic process|regulation of gene expression|complement activation, classical pathway|protein catabolic process|negative regulation of gene expression|regulation of inflammatory response|blood coagulation|protein maturation|negative regulation of cellular protein metabolic process|wound healing|inflammatory response|hemostasis|regulation of complement activation|regulation of endocytosis|positive regulation of protein metabolic process|proteolysis|negative regulation of adaptive immune response|regulation of opsonization|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|cellular protein metabolic process|regulation of protein catabolic process|gene expression|regulation of adaptive immune response|regulation of protein metabolic process|humoral immune response mediated by circulating immunoglobulin|regulation of humoral immune response|negative regulation of complement activation|regulation of acute inflammatory response|regulation of phagocytosis|protein processing|regulation of proteolysis|acute inflammatory response|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of complement activation, classical pathway|negative regulation of proteolysis|B cell mediated immunity|endocytosis|immunoglobulin mediated immune response|negative regulation of protein processing|regulation of protein processing K04003 complement component 4 binding protein, beta[-] hsa04610|hsa05133 Complement and coagulation cascades - Homo sapiens (human)|Pertussis - Homo sapiens (human) 1:207088842-207099993 14 6 9 3 4 0 0.200961067821268 0.0782718775313346 0.11647100117564 0.0385776174339451 0.0471056549593229 0 0.131901315509414 0.028561090797756 2.20733596872295 0.0015010726903199 0.00842191770283977 UP ENSG00000268751 SCGB1B2P secretoglobin, family 1B, member 2, pseudogene [Source:HGNC Symbol;Acc:HGNC:20741] - - - - - - 19:34576733-34577701 0 0 1 5 5 5 0 0 0.0628026382461522 0.312189363476011 0.285911226821572 0.326600240038416 0.0209342127487174 0.308233610112 -3.88008961312015 0.00150501683459737 0.00843928861383731 DOWN ENSG00000091844 RGS17 regulator of G-protein signaling 17 [Source:HGNC Symbol;Acc:HGNC:14088] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0023057|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0005634 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|nucleus - - - - 6:153004459-153131249 46 58 59 88 124 135 0.363968279363914 0.41707645644139 0.420895407748936 0.623861596729901 0.80500668780383 1.00108544675597 0.40064671451808 0.809984577096567 -1.0155637919262 0.00150615836043756 0.00844410360422588 DOWN ENSG00000205740 RP11-363N22.3 - - - - - - - 10:971146-988341 8 5 11 28 27 18 0.113400501720505 0.0644222314735906 0.140586211981359 0.355631213382631 0.31402999771349 0.239135160380707 0.106136315058485 0.302932123825609 -1.51307620805574 0.00150743386278982 0.00844966776938174 DOWN ENSG00000272209 RP3-500L14.2 - - - - - - - 6:13825432-13826574 0 0 0 4 2 5 0 0 0 0.221805258466613 0.101547098704962 0.290025584985995 0 0.204459314052523 -Inf 0.00150902448762564 0.00845699588015316 DOWN ENSG00000229494 AC012494.1 - - - - - - - 2:78088730-78127806 0 0 0 5 2 4 0 0 0 0.287282143180554 0.105229677080482 0.240383482784109 0 0.210965101015048 -Inf 0.00151355694275999 0.0084776226959018 DOWN ENSG00000205628 LINC01446 long intergenic non-protein coding RNA 1446 [Source:HGNC Symbol;Acc:HGNC:50773] - - - - - - 7:53655509-53811931 18 12 18 25 51 63 0.36546222560731 0.221425839537553 0.329507731326304 0.454790257194272 0.849582645558393 1.19876451666161 0.305465265490389 0.834379139804758 -1.44969474943232 0.00152319043918189 0.00852358526173124 DOWN ENSG00000229267 AC072062.1 - - - - - - - 2:214810229-214963274 1 3 6 16 26 6 0.029973186540709 0.0816994201165092 0.162078912316934 0.4294915389654 0.639137900192672 0.168481570951593 0.0912505063247174 0.412370336703222 -2.17603608899691 0.00153260734751203 0.00856748907932861 DOWN ENSG00000263126 CTC-479C5.10 - - - - - - - 16:67882461-67886367 35 29 40 6 22 17 0.633676502331488 0.477185099808263 0.652944799466292 0.0973343014182258 0.326815437603111 0.288456284853343 0.587935467202014 0.23753534129156 1.3075156327473 0.00153304504125991 0.00856748907932861 UP ENSG00000269026 AC003006.7 - GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57682045-57753575 7 6 6 15 23 23 0.594439461118372 0.463053796487895 0.459385728667804 1.14127338534994 1.60248862058916 1.83047262177518 0.505626328758024 1.52474487590476 -1.59242437357241 0.00153474094585228 0.0085753614444084 DOWN ENSG00000230445 LRRC37A6P leucine-rich repeat containing 37 member A6, pseudogene [Source:HGNC Symbol;Acc:HGNC:33746] - - - - - - 10:27246350-27259455 89 125 63 50 48 47 0.639080832063418 0.815748978229779 0.407868962873043 0.32168453902321 0.282795084328628 0.316298155847646 0.620899591055413 0.306925926399828 1.01646946436507 0.00153617351374074 0.00858037678700251 UP ENSG00000198929 NOS1AP nitric oxide synthase 1 adaptor protein [Source:HGNC Symbol;Acc:HGNC:16859] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0045760|GO:0098900|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0042175|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0030017|GO:0030018|GO:0051272|GO:1903409|GO:0042391|GO:0006810|GO:0010941|GO:0098797|GO:0033017|GO:0044853|GO:0034641|GO:2001057|GO:0043270|GO:0031325|GO:0005887|GO:0030315|GO:0043231|GO:0019899|GO:0005737|GO:0032970|GO:0003012|GO:0043235|GO:0005635|GO:0006928|GO:0072593|GO:0098901|GO:0009966|GO:1903524|GO:0042383|GO:0031674|GO:0010646|GO:0031226|GO:0043085|GO:1902495|GO:0007154|GO:0055085|GO:0051270|GO:0007165|GO:0005783|GO:0008219|GO:0031965|GO:0050790|GO:0071804|GO:0002027|GO:0016021|GO:0030029|GO:0098903|GO:0009967|GO:0044249|GO:0019538|GO:0098857|GO:0031323|GO:0032411|GO:0003013|GO:1902533|GO:0005901|GO:0032268|GO:0005829|GO:1902937|GO:0086009|GO:0010468|GO:0006936|GO:0016528|GO:0043412|GO:0030048|GO:0050998|GO:0045823|GO:0090257|GO:0045989|GO:0001508|GO:0010628|GO:0034767|GO:0036211|GO:2000377|GO:0006811|GO:0046209|GO:1903428|GO:0008076|GO:0005891|GO:0043292|GO:1990454|GO:0051247|GO:0048471|GO:0034765|GO:0045428|GO:0034702|GO:0005739|GO:0051353|GO:0043269|GO:0043268|GO:0051341|GO:0032270|GO:0012501|GO:0035556|GO:0044267|GO:0010467|GO:0032414|GO:0003062|GO:0060306|GO:0031328|GO:0006809|GO:0051246|GO:0071805|GO:0045121|GO:1902531|GO:0008015|GO:0005634|GO:0016529|GO:0043067|GO:0098911|GO:1903426|GO:0022898|GO:0034220|GO:2000379|GO:0006941|GO:0008016|GO:0098655|GO:0070252|GO:0086011|GO:0086001|GO:0030016|GO:0031401|GO:1901379|GO:0006937|GO:0010750|GO:0032770|GO:0060047|GO:0034703|GO:0006812|GO:1903762|GO:0086004|GO:0060452|GO:0032412|GO:2001259|GO:0042981|GO:0045429|GO:0006464|GO:0019932|GO:1901381|GO:0006915|GO:1901018|GO:0086003|GO:0051000|GO:0060307|GO:1903169|GO:1901016|GO:0043266|GO:0086013|GO:0034705|GO:0006942|GO:0086002|GO:0060048|GO:0018193|GO:0034704|GO:0050999|GO:0055117|GO:1901019|GO:0030001|GO:0051924|GO:2001257|GO:2000170|GO:0007263|GO:0015672|GO:1902259|GO:0018119|GO:0006813|GO:1902261|GO:1901385|GO:0070588|GO:1902514|GO:0086005|GO:1901841|GO:0006816 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|positive regulation of action potential|regulation of action potential|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|sarcomere|Z disc|positive regulation of cellular component movement|reactive oxygen species biosynthetic process|regulation of membrane potential|transport|regulation of cell death|plasma membrane protein complex|sarcoplasmic reticulum membrane|plasma membrane raft|cellular nitrogen compound metabolic process|reactive nitrogen species metabolic process|positive regulation of ion transport|positive regulation of cellular metabolic process|integral component of plasma membrane|T-tubule|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|regulation of actin filament-based process|muscle system process|receptor complex|nuclear envelope|movement of cell or subcellular component|reactive oxygen species metabolic process|regulation of cardiac muscle cell action potential|regulation of signal transduction|positive regulation of blood circulation|sarcolemma|I band|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|transmembrane transporter complex|cell communication|transmembrane transport|regulation of cellular component movement|signal transduction|endoplasmic reticulum|cell death|nuclear membrane|regulation of catalytic activity|cellular potassium ion transport|regulation of heart rate|integral component of membrane|actin filament-based process|regulation of membrane repolarization during action potential|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|membrane microdomain|regulation of cellular metabolic process|positive regulation of transporter activity|circulatory system process|positive regulation of intracellular signal transduction|caveola|regulation of cellular protein metabolic process|cytosol|inward rectifier potassium channel complex|membrane repolarization|regulation of gene expression|muscle contraction|sarcoplasm|macromolecule modification|actin filament-based movement|nitric-oxide synthase binding|positive regulation of heart contraction|regulation of muscle system process|positive regulation of striated muscle contraction|action potential|positive regulation of gene expression|positive regulation of ion transmembrane transport|protein modification process|regulation of reactive oxygen species metabolic process|ion transport|nitric oxide metabolic process|positive regulation of reactive oxygen species biosynthetic process|voltage-gated potassium channel complex|voltage-gated calcium channel complex|contractile fiber|L-type voltage-gated calcium channel complex|positive regulation of protein metabolic process|perinuclear region of cytoplasm|regulation of ion transmembrane transport|regulation of nitric oxide biosynthetic process|ion channel complex|mitochondrion|positive regulation of oxidoreductase activity|regulation of ion transport|positive regulation of potassium ion transport|regulation of oxidoreductase activity|positive regulation of cellular protein metabolic process|programmed cell death|intracellular signal transduction|cellular protein metabolic process|gene expression|positive regulation of ion transmembrane transporter activity|regulation of heart rate by chemical signal|regulation of membrane repolarization|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|potassium ion transmembrane transport|membrane raft|regulation of intracellular signal transduction|blood circulation|nucleus|sarcoplasmic reticulum|regulation of programmed cell death|regulation of ventricular cardiac muscle cell action potential|regulation of reactive oxygen species biosynthetic process|regulation of transmembrane transporter activity|ion transmembrane transport|positive regulation of reactive oxygen species metabolic process|striated muscle contraction|regulation of heart contraction|cation transmembrane transport|actin-mediated cell contraction|membrane repolarization during action potential|cardiac muscle cell action potential|myofibril|positive regulation of protein modification process|regulation of potassium ion transmembrane transport|regulation of muscle contraction|positive regulation of nitric oxide mediated signal transduction|positive regulation of monooxygenase activity|heart contraction|cation channel complex|cation transport|positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|regulation of cardiac muscle cell contraction|positive regulation of cardiac muscle contraction|regulation of ion transmembrane transporter activity|positive regulation of cation channel activity|regulation of apoptotic process|positive regulation of nitric oxide biosynthetic process|cellular protein modification process|second-messenger-mediated signaling|positive regulation of potassium ion transmembrane transport|apoptotic process|positive regulation of potassium ion transmembrane transporter activity|cardiac muscle cell contraction|positive regulation of nitric-oxide synthase activity|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of calcium ion transmembrane transport|regulation of potassium ion transmembrane transporter activity|regulation of potassium ion transport|membrane repolarization during cardiac muscle cell action potential|potassium channel complex|regulation of striated muscle contraction|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|peptidyl-amino acid modification|calcium channel complex|regulation of nitric-oxide synthase activity|regulation of cardiac muscle contraction|regulation of calcium ion transmembrane transporter activity|metal ion transport|regulation of calcium ion transport|regulation of cation channel activity|positive regulation of peptidyl-cysteine S-nitrosylation|nitric oxide mediated signal transduction|monovalent inorganic cation transport|regulation of delayed rectifier potassium channel activity|peptidyl-cysteine S-nitrosylation|potassium ion transport|positive regulation of delayed rectifier potassium channel activity|regulation of voltage-gated calcium channel activity|calcium ion transmembrane transport|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|ventricular cardiac muscle cell action potential|regulation of high voltage-gated calcium channel activity|calcium ion transport K16513 carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein[-] hsa04713 Circadian entrainment - Homo sapiens (human) 1:162069774-162370475 49 53 119 133 168 206 0.243065233999462 0.238938109035663 0.532217483641274 0.591119555733157 0.68376139530491 0.957682745429142 0.338073608892133 0.744187898822403 -1.1383295318754 0.00154265651613134 0.00860992103806038 DOWN ENSG00000279968 GVQW2 GVQW motif containing 2 [Source:HGNC Symbol;Acc:HGNC:51715] - - - - - - 6:138725211-138773652 1 1 4 7 12 10 0.0236440672978997 0.0214893841419777 0.0852362873327277 0.148223825306321 0.232699005769316 0.221492806724886 0.0434565795908684 0.200805212600174 -2.20815018845261 0.00154371961351547 0.00861424398913845 DOWN ENSG00000131737 KRT34 keratin 34, type I [Source:HGNC Symbol;Acc:HGNC:6452] GO:0032502|GO:0005198|GO:0005623|GO:0005576|GO:1903561|GO:0043229|GO:0043227|GO:0005615|GO:0005622|GO:0048856|GO:0009888|GO:0031982|GO:0005882|GO:0070062|GO:0060429|GO:0005856|GO:0008544|GO:0045111 developmental process|structural molecule activity|cell|extracellular region|extracellular vesicle|intracellular organelle|membrane-bounded organelle|extracellular space|intracellular|anatomical structure development|tissue development|vesicle|intermediate filament|extracellular exosome|epithelium development|cytoskeleton|epidermis development|intermediate filament cytoskeleton - - - - 17:41377650-41382403 9 8 10 0 2 4 0.363583778987969 0.29371697123504 0.364237875480945 0 0.066286883963319 0.151423747293474 0.340512875234651 0.072570210418931 2.23025999116051 0.00154421876818074 0.00861541900677778 UP ENSG00000223855 HRAT92 heart tissue-associated transcript 92 [Source:EntrezGene;Acc:441307] - - - - - - 7:520391-525232 20 14 45 73 53 82 0.403518973163776 0.256709135512542 0.818571653542927 1.31963546627747 0.877357179391105 1.55052375598314 0.492933254073082 1.24917213388391 -1.34150807572812 0.00154689528304019 0.00862551583486774 DOWN ENSG00000150672 DLG2 discs, large homolog 2 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:2901] GO:0032502|GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0003824|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0051641|GO:0016043|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0016740|GO:0048856|GO:0097060|GO:0019222|GO:0006725|GO:1901360|GO:0098797|GO:0007275|GO:0050877|GO:0005102|GO:0034641|GO:0044281|GO:0016772|GO:0019637|GO:0046483|GO:0045211|GO:0051668|GO:0005887|GO:0019899|GO:0007267|GO:0043235|GO:0043005|GO:0097481|GO:0014069|GO:0006139|GO:0031226|GO:0055086|GO:0008104|GO:1902495|GO:0007154|GO:0044092|GO:0061024|GO:0050790|GO:0043086|GO:0016021|GO:0019538|GO:0031324|GO:0031323|GO:0043113|GO:0032268|GO:0008328|GO:0044224|GO:0030424|GO:0043412|GO:0019693|GO:0036211|GO:0032269|GO:0009116|GO:0044304|GO:0007600|GO:0008076|GO:0072657|GO:0051346|GO:0034702|GO:0035418|GO:0016301|GO:0034613|GO:0019900|GO:0006796|GO:0044267|GO:0051174|GO:0007399|GO:0051246|GO:0016776|GO:0035254|GO:0010923|GO:0016311|GO:0019233|GO:0009259|GO:0009117|GO:0035255|GO:0034703|GO:0019205|GO:0097120|GO:0004385|GO:0009132|GO:0006163|GO:0006464|GO:0042278|GO:0010921|GO:0006470|GO:0035304|GO:0034705|GO:0019201|GO:0035305|GO:0035303|GO:0007268|GO:0035308|GO:0046037|GO:0046710 developmental process|macromolecular complex|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|binding|catalytic activity|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular localization|cellular component organization|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|transferase activity|anatomical structure development|synaptic membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|plasma membrane protein complex|multicellular organism development|neurological system process|receptor binding|cellular nitrogen compound metabolic process|small molecule metabolic process|transferase activity, transferring phosphorus-containing groups|organophosphate metabolic process|heterocycle metabolic process|postsynaptic membrane|localization within membrane|integral component of plasma membrane|enzyme binding|cell-cell signaling|receptor complex|neuron projection|neuronal postsynaptic density|postsynaptic density|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|nucleobase-containing small molecule metabolic process|protein localization|transmembrane transporter complex|cell communication|negative regulation of molecular function|membrane organization|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|receptor clustering|regulation of cellular protein metabolic process|ionotropic glutamate receptor complex|juxtaparanode region of axon|axon|macromolecule modification|ribose phosphate metabolic process|protein modification process|negative regulation of cellular protein metabolic process|nucleoside metabolic process|main axon|sensory perception|voltage-gated potassium channel complex|protein localization to membrane|negative regulation of hydrolase activity|ion channel complex|protein localization to synapse|kinase activity|cellular protein localization|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|nervous system development|regulation of protein metabolic process|phosphotransferase activity, phosphate group as acceptor|glutamate receptor binding|negative regulation of phosphatase activity|dephosphorylation|sensory perception of pain|ribonucleotide metabolic process|nucleotide metabolic process|ionotropic glutamate receptor binding|cation channel complex|nucleobase-containing compound kinase activity|receptor localization to synapse|guanylate kinase activity|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|cellular protein modification process|purine nucleoside metabolic process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|potassium channel complex|nucleotide kinase activity|negative regulation of dephosphorylation|regulation of dephosphorylation|synaptic transmission|negative regulation of protein dephosphorylation|GMP metabolic process|GDP metabolic process K12075 discs large protein 2/3[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) 11:83455012-85627922 6 6 7 21 16 24 0.0144935925718527 0.013172727698737 0.0152453039341618 0.0454533790600883 0.0317124783794518 0.0543360917736644 0.0143038747349172 0.0438339830710682 -1.61564377107163 0.00154866918574005 0.00863057119116732 DOWN ENSG00000254461 RP11-755F10.3 - - - - - - - 11:66259567-66261834 17 21 18 6 9 7 2.23099016807654 2.50475652749226 2.12987928745982 0.705538247942501 0.969084532214172 0.860984664924728 2.28854199434287 0.8452024816938 1.43705985693117 0.00155180586731649 0.00864643754439464 UP ENSG00000137440 FGFBP1 fibroblast growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:19695] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0009056|GO:0043167|GO:0009986|GO:0006914|GO:0023051|GO:0016043|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0005615|GO:0002682|GO:0005515|GO:0005886|GO:0008284|GO:0042127|GO:0008201|GO:0019838|GO:0050688|GO:0043168|GO:0006952|GO:0033554|GO:0090287|GO:0098542|GO:0007267|GO:0009615|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0000422|GO:0008285|GO:0016236|GO:0051607|GO:0009967|GO:0005539|GO:0010033|GO:0006996|GO:0071774|GO:0040036|GO:1903008|GO:0098792|GO:0007166|GO:0000423|GO:0007005|GO:0044344|GO:0070848|GO:0071310|GO:0045743|GO:0017134|GO:0050691|GO:0008543|GO:0071363|GO:0002230|GO:0007167|GO:0098779|GO:0007169 immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|catabolic process|ion binding|cell surface|autophagy|regulation of signaling|cellular component organization|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|extracellular space|regulation of immune system process|protein binding|plasma membrane|positive regulation of cell proliferation|regulation of cell proliferation|heparin binding|growth factor binding|regulation of defense response to virus|anion binding|defense response|cellular response to stress|regulation of cellular response to growth factor stimulus|defense response to other organism|cell-cell signaling|response to virus|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|mitophagy|negative regulation of cell proliferation|macroautophagy|defense response to virus|positive regulation of signal transduction|glycosaminoglycan binding|response to organic substance|organelle organization|response to fibroblast growth factor|regulation of fibroblast growth factor receptor signaling pathway|organelle disassembly|xenophagy|cell surface receptor signaling pathway|macromitophagy|mitochondrion organization|cellular response to fibroblast growth factor stimulus|response to growth factor|cellular response to organic substance|positive regulation of fibroblast growth factor receptor signaling pathway|fibroblast growth factor binding|regulation of defense response to virus by host|fibroblast growth factor receptor signaling pathway|cellular response to growth factor stimulus|positive regulation of defense response to virus by host|enzyme linked receptor protein signaling pathway|mitophagy in response to mitochondrial depolarization|transmembrane receptor protein tyrosine kinase signaling pathway - - - - 4:15935569-15938740 23 18 24 40 53 69 1.19718273674109 0.851487444755887 1.12627409828358 1.86546724507825 2.26343949296925 3.36591653058555 1.05831475992685 2.49827442287768 -1.23916318633115 0.00155478677684588 0.0086605929567147 DOWN ENSG00000279289 RP3-331H24.6 - - - - - - - 6:71386852-71390829 0 4 3 12 6 18 0 0.0646428376863444 0.0480896887413956 0.191194125510814 0.0875326801054085 0.299970952815417 0.0375775088092467 0.192899252810547 -2.35990622319761 0.00156054198974802 0.00869024819286277 DOWN ENSG00000218073 RP1-13D10.2 - - - - - - - 6:16160926-16161411 22 27 15 11 9 5 3.20206717244553 3.57157938434721 1.96838972381447 1.43448008141802 1.07476659025399 0.682097209133729 2.91401209353574 1.06378129360191 1.45380529202323 0.00156812369671915 0.00872921216517874 UP ENSG00000178342 KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 [Source:HGNC Symbol;Acc:HGNC:6249] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0022857|GO:0050794|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0060341|GO:0006810|GO:0098797|GO:0015980|GO:0044281|GO:0032940|GO:0031982|GO:0022607|GO:0005887|GO:0007267|GO:0032880|GO:0045184|GO:0046883|GO:0022891|GO:0010646|GO:0031226|GO:0008104|GO:1902495|GO:0007154|GO:0055085|GO:0070062|GO:0071804|GO:0006091|GO:0010817|GO:0016021|GO:0003013|GO:0055114|GO:0090276|GO:0051223|GO:0015031|GO:0070201|GO:0015267|GO:0042886|GO:0006811|GO:0015075|GO:0008076|GO:0051046|GO:0009914|GO:0009306|GO:0034765|GO:0034702|GO:0006461|GO:0043269|GO:0006112|GO:0046903|GO:0071805|GO:0008015|GO:0034220|GO:0050796|GO:0008016|GO:0002790|GO:0030073|GO:0098655|GO:0005216|GO:0051259|GO:0060047|GO:0034703|GO:0006812|GO:0050708|GO:0015833|GO:0046879|GO:0008324|GO:0030072|GO:0005244|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:0051260|GO:0015672|GO:0007268|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249|GO:0005251 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|transmembrane transporter activity|regulation of cellular process|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|protein complex|regulation of cellular localization|transport|plasma membrane protein complex|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|vesicle|cellular component assembly|integral component of plasma membrane|cell-cell signaling|regulation of protein localization|establishment of protein localization|regulation of hormone secretion|substrate-specific transmembrane transporter activity|regulation of cell communication|intrinsic component of plasma membrane|protein localization|transmembrane transporter complex|cell communication|transmembrane transport|extracellular exosome|cellular potassium ion transport|generation of precursor metabolites and energy|regulation of hormone levels|integral component of membrane|circulatory system process|oxidation-reduction process|regulation of peptide hormone secretion|regulation of protein transport|protein transport|regulation of establishment of protein localization|channel activity|amide transport|ion transport|ion transmembrane transporter activity|voltage-gated potassium channel complex|regulation of secretion|hormone transport|protein secretion|regulation of ion transmembrane transport|ion channel complex|protein complex assembly|regulation of ion transport|energy reserve metabolic process|secretion|potassium ion transmembrane transport|blood circulation|ion transmembrane transport|regulation of insulin secretion|regulation of heart contraction|peptide secretion|insulin secretion|cation transmembrane transport|ion channel activity|protein oligomerization|heart contraction|cation channel complex|cation transport|regulation of protein secretion|peptide transport|hormone secretion|cation transmembrane transporter activity|peptide hormone secretion|voltage-gated ion channel activity|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|protein homooligomerization|monovalent inorganic cation transport|synaptic transmission|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity|delayed rectifier potassium channel activity - - - - 18:79863668-79900184 19 21 14 8 7 5 0.457288474477572 0.459361608818758 0.30380834568016 0.172523586544633 0.138233490657934 0.112793209812519 0.406819476325497 0.141183429005029 1.52681798291231 0.00157355806944523 0.00875619806248237 UP ENSG00000274024 RP13-210D15.8 - - - - - - - X:135297046-135298585 3 3 3 9 14 16 0.186825545175127 0.169799587055527 0.168398575539852 0.502108815453776 0.715260966626175 0.933726196781948 0.175007902590169 0.717031992953966 -2.03461742206063 0.00157391183220536 0.00875653444626517 DOWN ENSG00000232973 CYP1B1-AS1 CYP1B1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:28543] - - - - - - 2:38073447-38231651 20 25 22 51 49 57 0.131212902978316 0.149064457116918 0.130128955256349 0.299789214026201 0.26376160297771 0.35047125800248 0.136802105117194 0.30467402500213 -1.15517607758237 0.0015748565295534 0.00875852586313101 DOWN ENSG00000267343 ZNF833P zinc finger protein 833, pseudogene [Source:HGNC Symbol;Acc:HGNC:33819] - - - - - - 19:11680944-11686259 9 6 0 0 0 0 0.219000755764683 0.13268792998776 0 0 0 0 0.117229561917481 0 Inf 0.00157844901657591 0.00877196890187216 UP ENSG00000160870 CYP3A7 cytochrome P450 family 3 subfamily A member 7 [Source:HGNC Symbol;Acc:HGNC:2640] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0016491|GO:0043229|GO:0042175|GO:0043167|GO:0044237|GO:0043227|GO:0019825|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0009410|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0004497|GO:0005783|GO:0006805|GO:0055114|GO:0046872|GO:0020037|GO:0071466|GO:0016712|GO:0070330|GO:0046914|GO:0005506 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|cellular metabolic process|membrane-bounded organelle|oxygen binding|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|response to xenobiotic stimulus|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|endoplasmic reticulum|xenobiotic metabolic process|oxidation-reduction process|metal ion binding|heme binding|cellular response to xenobiotic stimulus|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|aromatase activity|transition metal ion binding|iron ion binding K17691 cytochrome P450, family 3, subfamily A, polypeptide 7[1.14.14.1] hsa01100|hsa05204|hsa00830|hsa00140 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human) 7:99705037-99735196 0 4 1 5 13 12 0 0.0571442685147284 0.0141654839599654 0.0704160453173669 0.167660717889552 0.176777658062893 0.0237699174915646 0.138284807089937 -2.54043386027692 0.00158374054123269 0.00879810013359897 DOWN ENSG00000118307 CASC1 cancer susceptibility candidate 1 [Source:HGNC Symbol;Acc:HGNC:29599] - - - - - - 12:25108420-25195162 8 5 18 28 32 29 0.103810035513726 0.0589739378193391 0.210604464491074 0.325554899060599 0.340709885124603 0.352687243846089 0.124462812608046 0.33965067601043 -1.44833697190197 0.00158462092748625 0.0088013531477534 DOWN ENSG00000103740 ACSBG1 acyl-CoA synthetase bubblegum family member 1 [Source:HGNC Symbol;Acc:HGNC:29567] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0043229|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0043227|GO:0009058|GO:0016874|GO:0005622|GO:0012505|GO:0048856|GO:0045137|GO:0044255|GO:0006082|GO:0007275|GO:0048513|GO:0043168|GO:0044281|GO:0001882|GO:0031982|GO:0001552|GO:0043231|GO:0048608|GO:0005737|GO:0007548|GO:0051186|GO:0008406|GO:0006629|GO:0005783|GO:0009725|GO:0000166|GO:0044249|GO:0010033|GO:0006790|GO:0005829|GO:0046486|GO:0033993|GO:0035639|GO:0008585|GO:0061458|GO:0031410|GO:0006637|GO:0006631|GO:0001883|GO:0046545|GO:0016023|GO:0032549|GO:0006638|GO:0031988|GO:0014070|GO:0008610|GO:0007399|GO:0017076|GO:0015645|GO:0048545|GO:0008366|GO:0031957|GO:0005524|GO:0001676|GO:0030554|GO:0009108|GO:0000038|GO:0019752|GO:0006639|GO:0042552|GO:0031960|GO:0004467|GO:0051384|GO:0046949|GO:0032787|GO:0035336|GO:0006641|GO:0019432|GO:0035338 developmental process|reproduction|cell|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|intracellular organelle|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|membrane-bounded organelle|biosynthetic process|ligase activity|intracellular|endomembrane system|anatomical structure development|development of primary sexual characteristics|cellular lipid metabolic process|organic acid metabolic process|multicellular organism development|animal organ development|anion binding|small molecule metabolic process|nucleoside binding|vesicle|ovarian follicle atresia|intracellular membrane-bounded organelle|reproductive structure development|cytoplasm|sex differentiation|cofactor metabolic process|gonad development|lipid metabolic process|endoplasmic reticulum|response to hormone|nucleotide binding|cellular biosynthetic process|response to organic substance|sulfur compound metabolic process|cytosol|glycerolipid metabolic process|response to lipid|purine ribonucleoside triphosphate binding|female gonad development|reproductive system development|cytoplasmic vesicle|acyl-CoA metabolic process|fatty acid metabolic process|purine nucleoside binding|development of primary female sexual characteristics|cytoplasmic, membrane-bounded vesicle|ribonucleoside binding|neutral lipid metabolic process|membrane-bounded vesicle|response to organic cyclic compound|lipid biosynthetic process|nervous system development|purine nucleotide binding|fatty acid ligase activity|response to steroid hormone|axon ensheathment|very long-chain fatty acid-CoA ligase activity|ATP binding|long-chain fatty acid metabolic process|adenyl nucleotide binding|coenzyme biosynthetic process|very long-chain fatty acid metabolic process|carboxylic acid metabolic process|acylglycerol metabolic process|myelination|response to corticosteroid|long-chain fatty acid-CoA ligase activity|response to glucocorticoid|fatty-acyl-CoA biosynthetic process|monocarboxylic acid metabolic process|long-chain fatty-acyl-CoA metabolic process|triglyceride metabolic process|triglyceride biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process K15013 long-chain-fatty-acid--CoA ligase ACSBG[6.2.1.3] hsa01100|hsa04920|hsa03320|hsa01212|hsa00071|hsa00061 Metabolic pathways - Homo sapiens (human)|Adipocytokine signaling pathway - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human)|Fatty acid metabolism - Homo sapiens (human)|Fatty acid degradation - Homo sapiens (human)|Fatty acid biosynthesis - Homo sapiens (human) 15:78167468-78245688 8 5 4 28 8 46 0.0506370025579705 0.0287666161121447 0.0228288329294724 0.158800872910902 0.0415509133447892 0.272885626051637 0.0340774838665292 0.157745804102443 -2.21071090904809 0.00159076769294962 0.00883220730989733 DOWN ENSG00000008513 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:10862] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0044255|GO:0031228|GO:0006082|GO:0034641|GO:0044281|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0006629|GO:0070062|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0031301|GO:0005794|GO:0006790|GO:0009311|GO:0006490|GO:0034645|GO:0006665|GO:0043412|GO:0006487|GO:0006643|GO:0030173|GO:0006493|GO:0009100|GO:0036211|GO:0006040|GO:0008373|GO:0070085|GO:0006796|GO:0043603|GO:0005795|GO:1901137|GO:0044267|GO:0042339|GO:0008610|GO:0000139|GO:0009059|GO:0009101|GO:0006672|GO:0043413|GO:0003836|GO:0006687|GO:0006054|GO:0006488|GO:0009247|GO:0018279|GO:0016310|GO:0097503|GO:0031985|GO:0006664|GO:0032580|GO:0006024|GO:0019752|GO:0030203|GO:0018146|GO:0030148|GO:0006464|GO:0016266|GO:0046513|GO:0006688|GO:0006468|GO:0018193|GO:0043687|GO:0001573|GO:0001574 cell|membrane|cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|cellular lipid metabolic process|intrinsic component of Golgi membrane|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|lipid metabolic process|extracellular exosome|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|integral component of organelle membrane|Golgi apparatus|sulfur compound metabolic process|oligosaccharide metabolic process|oligosaccharide-lipid intermediate biosynthetic process|cellular macromolecule biosynthetic process|sphingolipid metabolic process|macromolecule modification|protein N-linked glycosylation|membrane lipid metabolic process|integral component of Golgi membrane|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|amino sugar metabolic process|sialyltransferase activity|glycosylation|phosphate-containing compound metabolic process|cellular amide metabolic process|Golgi stack|carbohydrate derivative biosynthetic process|cellular protein metabolic process|keratan sulfate metabolic process|lipid biosynthetic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|ceramide metabolic process|macromolecule glycosylation|beta-galactoside (CMP) alpha-2,3-sialyltransferase activity|glycosphingolipid metabolic process|N-acetylneuraminate metabolic process|dolichol-linked oligosaccharide biosynthetic process|glycolipid biosynthetic process|protein N-linked glycosylation via asparagine|phosphorylation|sialylation|Golgi cisterna|glycolipid metabolic process|Golgi cisterna membrane|glycosaminoglycan biosynthetic process|carboxylic acid metabolic process|glycosaminoglycan metabolic process|keratan sulfate biosynthetic process|sphingolipid biosynthetic process|cellular protein modification process|O-glycan processing|ceramide biosynthetic process|glycosphingolipid biosynthetic process|protein phosphorylation|peptidyl-amino acid modification|post-translational protein modification|ganglioside metabolic process|ganglioside biosynthetic process K00780 beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4A)[2.4.99.4] hsa01100|hsa00512|hsa00604|hsa00533|hsa00603 Metabolic pathways - Homo sapiens (human)|Mucin type O-Glycan biosynthesis - Homo sapiens (human)|Glycosphingolipid biosynthesis - ganglio series - Homo sapiens (human)|Glycosaminoglycan biosynthesis - keratan sulfate - Homo sapiens (human)|Glycosphingolipid biosynthesis - globo series - Homo sapiens (human) 8:133454848-133571940 460 606 1542 1843 1823 1856 1.62135447496041 1.94121111710757 4.90025510695551 5.82026847796879 5.27199065753216 6.13093759476719 2.82094023300783 5.74106557675605 -1.0251424347405 0.00159653473738669 0.00886093103735678 DOWN ENSG00000272563 RP11-480C16.1 - - - - - - - 2:113432600-113436042 1 2 2 4 10 15 0.0205537883887929 0.0373437711757592 0.0370479535269901 0.0736344497320183 0.168573857231424 0.288825795575537 0.0316485043638474 0.177011367512993 -2.48363278397988 0.00159699624481058 0.00886159425418323 DOWN ENSG00000066230 SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 [Source:HGNC Symbol;Acc:HGNC:11073] GO:0005215|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0042995|GO:0022857|GO:0007623|GO:0009986|GO:0045177|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0005903|GO:0006810|GO:0016324|GO:0031982|GO:0042592|GO:0022891|GO:0019904|GO:0055085|GO:0070062|GO:0009725|GO:0031253|GO:0016021|GO:0010033|GO:0016192|GO:0033993|GO:0048878|GO:0031526|GO:0030165|GO:0006811|GO:0015075|GO:0031988|GO:0043269|GO:0014070|GO:0048545|GO:0034220|GO:0098655|GO:0015992|GO:0015297|GO:0006812|GO:0050801|GO:0006897|GO:0031960|GO:0008324|GO:0051384|GO:1902600|GO:0006898|GO:0022890|GO:0015491|GO:0002028|GO:0030001|GO:0015672|GO:0005451|GO:0035725|GO:0006814|GO:0015299|GO:0015077|GO:0046873|GO:0015385|GO:0015078|GO:0006885|GO:0015081 transporter activity|cell|rhythmic process|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cell projection|transmembrane transporter activity|circadian rhythm|cell surface|apical part of cell|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|brush border|transport|apical plasma membrane|vesicle|homeostatic process|substrate-specific transmembrane transporter activity|protein domain specific binding|transmembrane transport|extracellular exosome|response to hormone|cell projection membrane|integral component of membrane|response to organic substance|vesicle-mediated transport|response to lipid|chemical homeostasis|brush border membrane|PDZ domain binding|ion transport|ion transmembrane transporter activity|membrane-bounded vesicle|regulation of ion transport|response to organic cyclic compound|response to steroid hormone|ion transmembrane transport|cation transmembrane transport|proton transport|antiporter activity|cation transport|ion homeostasis|endocytosis|response to corticosteroid|cation transmembrane transporter activity|response to glucocorticoid|hydrogen ion transmembrane transport|receptor-mediated endocytosis|inorganic cation transmembrane transporter activity|cation:cation antiporter activity|regulation of sodium ion transport|metal ion transport|monovalent inorganic cation transport|monovalent cation:proton antiporter activity|sodium ion transmembrane transport|sodium ion transport|solute:proton antiporter activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|sodium:proton antiporter activity|hydrogen ion transmembrane transporter activity|regulation of pH|sodium ion transmembrane transporter activity K12040 solute carrier family 9 (sodium/hydrogen exchanger), member 3[-] hsa04974|hsa04976|hsa04978|hsa04964 Protein digestion and absorption - Homo sapiens (human)|Bile secretion - Homo sapiens (human)|Mineral absorption - Homo sapiens (human)|Proximal tubule bicarbonate reclamation - Homo sapiens (human) 5:473310-524332 5 5 6 16 15 23 0.106729313583366 0.0970026961536564 0.11547022087516 0.305983561707094 0.262703586503225 0.460103709697864 0.106400743537394 0.342930285969394 -1.6884070893049 0.00159798195090862 0.00886401953965551 DOWN ENSG00000227674 LINC00355 long intergenic non-protein coding RNA 355 [Source:HGNC Symbol;Acc:HGNC:27061] - - - - - - 13:63986371-64076011 2 2 2 7 12 12 0.0753286080385144 0.0684635804888919 0.0679212481328152 0.236226788680416 0.37085629620211 0.423588637530894 0.0705711455534072 0.343557240804473 -2.28340015557701 0.00160530133825715 0.00889635532807295 DOWN ENSG00000139800 ZIC5 Zic family member 5 [Source:HGNC Symbol;Acc:HGNC:20322] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0097159|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0048856|GO:0007275|GO:0003676|GO:0043231|GO:0043169|GO:0048869|GO:0003677|GO:0046872|GO:0007399|GO:0030154|GO:0005634 developmental process|cell|cellular process|binding|organic cyclic compound binding|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|anatomical structure development|multicellular organism development|nucleic acid binding|intracellular membrane-bounded organelle|cation binding|cellular developmental process|DNA binding|metal ion binding|nervous system development|cell differentiation|nucleus - - - - 13:99962964-99971909 37 48 60 18 36 18 0.564182198858688 0.665184414700439 0.824879579963154 0.245913177131058 0.450387206607837 0.257228810152992 0.684748731174094 0.317843064630629 1.10726007863173 0.00160725415927922 0.0089022199760894 UP ENSG00000167840 ZNF232 zinc finger protein 232 [Source:HGNC Symbol;Acc:HGNC:13026] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 17:5105541-5123116 237 248 145 138 126 71 1.8311978612373 1.74148016554989 1.01011293503936 0.955350854034185 0.798779696645113 0.514129115873424 1.52759698727552 0.756086555517574 1.01464067347921 0.00161750026021353 0.00895232717249068 UP ENSG00000225556 C2CD4D C2 calcium-dependent domain containing 4D [Source:HGNC Symbol;Acc:HGNC:37210] GO:0005488|GO:0043167|GO:0008289|GO:0005515|GO:0043168|GO:0005543|GO:0043169|GO:0046872|GO:0005544|GO:0005509 binding|ion binding|lipid binding|protein binding|anion binding|phospholipid binding|cation binding|metal ion binding|calcium-dependent phospholipid binding|calcium ion binding - - - - 1:151837819-151840557 9 20 12 3 6 4 0.362342172457561 0.731784884223899 0.43559284232246 0.108201763639432 0.198181560306952 0.150906648554851 0.509906633001307 0.152429990833745 1.74208632183581 0.00161965270657997 0.00896257866584586 UP ENSG00000223745 RP4-717I23.3 CCDC18 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:52262] - - - - - - 1:93262186-93346025 28 53 70 92 108 147 0.185885126560067 0.319780144049606 0.418989220371888 0.547240364635632 0.588277510625078 0.914613172715288 0.30821816366052 0.683377015991999 -1.14872984236328 0.00162174447462178 0.00897082815367032 DOWN ENSG00000235385 GS1-600G8.5 - - - - - - - X:13266048-13303452 11 6 6 2 2 0 0.320999308128822 0.159126985344231 0.1578664653384 0.052294432843923 0.0478829759982556 0 0.212664252937151 0.0333924696140595 2.67098284867245 0.00164634097541778 0.00908668210022601 UP ENSG00000166800 LDHAL6A lactate dehydrogenase A-like 6A [Source:HGNC Symbol;Acc:HGNC:28335] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:1903561|GO:0016491|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0006082|GO:0044281|GO:0031982|GO:0016614|GO:0005737|GO:0005975|GO:0070062|GO:0055114|GO:0004457|GO:0016616|GO:0004459|GO:0019752 cell|cellular process|extracellular region|metabolic process|catalytic activity|extracellular vesicle|oxidoreductase activity|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|organic acid metabolic process|small molecule metabolic process|vesicle|oxidoreductase activity, acting on CH-OH group of donors|cytoplasm|carbohydrate metabolic process|extracellular exosome|oxidation-reduction process|lactate dehydrogenase activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|L-lactate dehydrogenase activity|carboxylic acid metabolic process K00016 L-lactate dehydrogenase[1.1.1.27] hsa01100|hsa00010 Metabolic pathways - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human) 11:18455824-18479600 12 25 21 4 8 9 0.228190595786795 0.432046499095324 0.360028418751106 0.0681514544159513 0.12482028403979 0.160387694932759 0.340088504544408 0.117786477796167 1.52973631839725 0.001651397994864 0.0091095409716685 UP ENSG00000247081 BAALC-AS1 BAALC antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:50461] - - - - - - 8:103156990-103298772 16 27 22 50 49 56 0.174553249247307 0.267703204934106 0.216386550828803 0.488728314916355 0.438599260226044 0.57256251671885 0.219547668336739 0.49996336395375 -1.18728816904586 0.0016547724559035 0.00912478332075047 DOWN ENSG00000232662 LDHBP1 lactate dehydrogenase B pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:6542] - - - - - - 13:113276616-113277734 5 5 1 0 0 0 0.316086635581121 0.287280549645413 0.0569657531902095 0 0 0 0.220110979472248 0 Inf 0.00165764060848736 0.0091383420826414 UP ENSG00000260306 RP11-645C24.5 - - - - - - - 16:21794095-21795759 14 11 18 6 5 4 0.594796481815741 0.424739187704285 0.689492454018525 0.228399468853458 0.174294231365703 0.159245033940464 0.569676041179517 0.187312911386542 1.60469138490689 0.00165784352916145 0.0091383420826414 UP ENSG00000161940 BCL6B B-cell CLL/lymphoma 6, member B [Source:HGNC Symbol;Acc:HGNC:1002] GO:0032502|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0045595|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0000981|GO:0009890|GO:0006139|GO:0048869|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0030097|GO:0010629|GO:0051252|GO:0010467|GO:0007399|GO:0001227|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0051960|GO:0000975|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0030099|GO:0022008|GO:0050767|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:0048699|GO:1903506|GO:0044212|GO:0000122|GO:0000976|GO:0001012|GO:0000977 developmental process|immune system process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|anatomical structure development|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|hemopoiesis|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|nervous system development|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|regulation of nervous system development|regulatory region DNA binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|myeloid cell differentiation|neurogenesis|regulation of neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 17:7023020-7030290 15 22 52 12 6 13 0.18967403909491 0.252828145466487 0.592848043524377 0.135961786071151 0.0622461568572247 0.154067880481076 0.345116742695258 0.117425274469817 1.55534149937622 0.00166879345309601 0.00919089459437974 UP ENSG00000187682 ERAS ES cell expressed Ras [Source:HGNC Symbol;Acc:HGNC:5174] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0043167|GO:0071944|GO:0005622|GO:0005886|GO:0006810|GO:0043168|GO:0001882|GO:0045184|GO:0008104|GO:0007154|GO:0007165|GO:0000166|GO:0035639|GO:0001883|GO:0015031|GO:0032549|GO:0035556|GO:0017076|GO:0032561|GO:0005525|GO:0007264|GO:0019001 signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|ion binding|cell periphery|intracellular|plasma membrane|transport|anion binding|nucleoside binding|establishment of protein localization|protein localization|cell communication|signal transduction|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|ribonucleoside binding|intracellular signal transduction|purine nucleotide binding|guanyl ribonucleotide binding|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding - - - - X:48828873-48830138 4 7 5 1 1 0 0.223486770768294 0.355483048350202 0.251861679152211 0.0500385414698357 0.0458635288975928 0 0.276943832756902 0.0319673567891428 3.11492204620657 0.00166891671454855 0.00919089459437974 UP ENSG00000066248 NGEF neuronal guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:HGNC:7807] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0050794|GO:0023051|GO:0009653|GO:0016043|GO:0030427|GO:0009605|GO:0009893|GO:0050793|GO:0005622|GO:0005515|GO:0005085|GO:0048856|GO:0019222|GO:0006935|GO:0045595|GO:0048468|GO:0010941|GO:0007275|GO:0045596|GO:0016358|GO:0051128|GO:0030426|GO:0010942|GO:0005737|GO:0005088|GO:0006928|GO:0043005|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0060996|GO:0007165|GO:0008219|GO:0050790|GO:0030030|GO:0048869|GO:0010033|GO:0050768|GO:0000902|GO:0060998|GO:0005829|GO:0031175|GO:2000171|GO:0031344|GO:0007166|GO:0060997|GO:0050773|GO:0051345|GO:0097061|GO:0048813|GO:0010721|GO:0000904|GO:0031345|GO:0070848|GO:0022604|GO:0012501|GO:0035556|GO:0032990|GO:0007399|GO:0071310|GO:0061000|GO:0097485|GO:0030154|GO:0048858|GO:0005089|GO:0043068|GO:1902531|GO:0043067|GO:0051960|GO:0097190|GO:0048666|GO:0030182|GO:0007411|GO:0010975|GO:0043065|GO:0010769|GO:0071363|GO:0043087|GO:0038179|GO:0061564|GO:0043547|GO:0007167|GO:0048814|GO:0042981|GO:0050774|GO:0045665|GO:0051056|GO:0022008|GO:0061002|GO:0048667|GO:0007264|GO:0050767|GO:0048812|GO:0010977|GO:0061001|GO:0006915|GO:0048011|GO:0007265|GO:0046578|GO:0007409|GO:0048699|GO:0045664|GO:0007169|GO:0048013|GO:0035023|GO:0007266 locomotion|developmental process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|regulation of cellular process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|site of polarized growth|response to external stimulus|positive regulation of metabolic process|regulation of developmental process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|chemotaxis|regulation of cell differentiation|cell development|regulation of cell death|multicellular organism development|negative regulation of cell differentiation|dendrite development|regulation of cellular component organization|growth cone|positive regulation of cell death|cytoplasm|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|neuron projection|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|dendritic spine development|signal transduction|cell death|regulation of catalytic activity|cell projection organization|cellular developmental process|response to organic substance|negative regulation of neurogenesis|cell morphogenesis|regulation of dendritic spine development|cytosol|neuron projection development|negative regulation of dendrite development|regulation of cell projection organization|cell surface receptor signaling pathway|dendritic spine morphogenesis|regulation of dendrite development|positive regulation of hydrolase activity|dendritic spine organization|dendrite morphogenesis|negative regulation of cell development|cell morphogenesis involved in differentiation|negative regulation of cell projection organization|response to growth factor|regulation of cell morphogenesis|programmed cell death|intracellular signal transduction|cell part morphogenesis|nervous system development|cellular response to organic substance|negative regulation of dendritic spine development|neuron projection guidance|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|regulation of programmed cell death|regulation of nervous system development|apoptotic signaling pathway|neuron development|neuron differentiation|axon guidance|regulation of neuron projection development|positive regulation of apoptotic process|regulation of cell morphogenesis involved in differentiation|cellular response to growth factor stimulus|regulation of GTPase activity|neurotrophin signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of dendrite morphogenesis|regulation of apoptotic process|negative regulation of dendrite morphogenesis|negative regulation of neuron differentiation|regulation of small GTPase mediated signal transduction|neurogenesis|negative regulation of dendritic spine morphogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|regulation of neurogenesis|neuron projection morphogenesis|negative regulation of neuron projection development|regulation of dendritic spine morphogenesis|apoptotic process|neurotrophin TRK receptor signaling pathway|Ras protein signal transduction|regulation of Ras protein signal transduction|axonogenesis|generation of neurons|regulation of neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|ephrin receptor signaling pathway|regulation of Rho protein signal transduction|Rho protein signal transduction K07525 neuronal guanine nucleotide exchange factor[-] hsa04360 Axon guidance - Homo sapiens (human) 2:232878686-233013272 51 52 126 141 184 195 0.614578767074729 0.569495691330769 1.36896666209961 1.52238699925204 1.81925763014568 2.20227295296666 0.851013706835036 1.84797252745479 -1.11868903540226 0.00167989753395881 0.00924795518694567 DOWN ENSG00000113763 UNC5A unc-5 netrin receptor A [Source:HGNC Symbol;Acc:HGNC:12567] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0050794|GO:0044297|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0031252|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0006935|GO:0048468|GO:0043025|GO:0007275|GO:0006928|GO:0043005|GO:0032809|GO:0036477|GO:0031226|GO:0007154|GO:0007165|GO:0032589|GO:0008219|GO:0031256|GO:0030030|GO:0031253|GO:0048869|GO:0016021|GO:0098857|GO:0000902|GO:0031175|GO:0007166|GO:0000904|GO:0012501|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0045121|GO:0097190|GO:0048666|GO:0030182|GO:0007411|GO:0097192|GO:0061564|GO:0022008|GO:0048667|GO:0038007|GO:0048812|GO:0097191|GO:0006915|GO:0007409|GO:0048699|GO:0033564 locomotion|developmental process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|regulation of cellular process|cell body|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|cell leading edge|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|chemotaxis|cell development|neuronal cell body|multicellular organism development|movement of cell or subcellular component|neuron projection|neuronal cell body membrane|somatodendritic compartment|intrinsic component of plasma membrane|cell communication|signal transduction|neuron projection membrane|cell death|leading edge membrane|cell projection organization|cell projection membrane|cellular developmental process|integral component of membrane|membrane microdomain|cell morphogenesis|neuron projection development|cell surface receptor signaling pathway|cell morphogenesis involved in differentiation|programmed cell death|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|membrane raft|apoptotic signaling pathway|neuron development|neuron differentiation|axon guidance|extrinsic apoptotic signaling pathway in absence of ligand|axon development|neurogenesis|cell morphogenesis involved in neuron differentiation|netrin-activated signaling pathway|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|apoptotic process|axonogenesis|generation of neurons|anterior/posterior axon guidance K07521 netrin receptor unc-5[-] hsa04360 Axon guidance - Homo sapiens (human) 5:176810477-176880895 86 83 287 283 337 586 1.27747825647581 1.12051165418325 3.84372119076097 3.76652082417467 4.1072826754161 8.15798245424623 2.08057036714001 5.343928651279 -1.36092166328372 0.00168161059686773 0.00925482160692643 DOWN ENSG00000150995 ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 [Source:HGNC Symbol;Acc:HGNC:6180] GO:0032502|GO:0032991|GO:0004871|GO:0005215|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0022857|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0006950|GO:0005057|GO:0042175|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0043227|GO:0008289|GO:0023057|GO:0009893|GO:0031224|GO:0008287|GO:0002684|GO:0016247|GO:0005622|GO:0002682|GO:0005789|GO:0005515|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0060341|GO:0002757|GO:0051282|GO:0050817|GO:0009791|GO:0045087|GO:0019866|GO:0006810|GO:0007275|GO:0043168|GO:0031095|GO:0015980|GO:0044281|GO:0032940|GO:0006952|GO:0005543|GO:0031982|GO:0033554|GO:0015278|GO:0030141|GO:0043231|GO:0005218|GO:0004888|GO:0005737|GO:0002218|GO:0007267|GO:0009611|GO:0005955|GO:0005246|GO:0032880|GO:0012506|GO:0005635|GO:0042592|GO:0001775|GO:0009966|GO:0045184|GO:0046883|GO:0019725|GO:0014069|GO:0022891|GO:0010646|GO:0043085|GO:0050776|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0050778|GO:0005783|GO:0009968|GO:0051649|GO:2000021|GO:0030667|GO:0008219|GO:0001666|GO:0031965|GO:0050790|GO:0006091|GO:0051238|GO:0010817|GO:0016021|GO:0010033|GO:0016248|GO:0050878|GO:0055114|GO:0071774|GO:0016192|GO:0005730|GO:0006909|GO:0030168|GO:0016528|GO:0007166|GO:0090276|GO:0002758|GO:0031410|GO:0051345|GO:0019855|GO:0048878|GO:0035091|GO:0007596|GO:0051223|GO:0015031|GO:0042827|GO:0051208|GO:0016023|GO:0008200|GO:0070201|GO:0042060|GO:0015267|GO:0046907|GO:0042886|GO:0042045|GO:0006811|GO:0051209|GO:0055082|GO:0002429|GO:0015075|GO:0005637|GO:0051046|GO:0031981|GO:0031094|GO:0007599|GO:0044344|GO:0009914|GO:0009306|GO:0070848|GO:0031988|GO:0002764|GO:0006112|GO:0012501|GO:0035556|GO:0030659|GO:0046903|GO:0071310|GO:1902532|GO:0031088|GO:0005220|GO:1902531|GO:0034976|GO:0050881|GO:0005634|GO:0016529|GO:0038096|GO:0045089|GO:0097190|GO:0045088|GO:0042044|GO:0034220|GO:0050796|GO:0070059|GO:0002790|GO:0015276|GO:0097193|GO:0030073|GO:0098655|GO:0005216|GO:0008543|GO:0006812|GO:0050882|GO:0050708|GO:0071363|GO:0015833|GO:0002768|GO:0038179|GO:0060402|GO:0007167|GO:0050801|GO:0050849|GO:0002431|GO:0006897|GO:0019932|GO:0050848|GO:0046879|GO:0060193|GO:0006915|GO:0006873|GO:0008324|GO:0048011|GO:0030072|GO:0002223|GO:0010517|GO:0038093|GO:0022890|GO:0030001|GO:0019722|GO:0048016|GO:0005261|GO:0010518|GO:0030003|GO:0007169|GO:0048010|GO:0005262|GO:0010863|GO:0038094|GO:0070588|GO:0055065|GO:0038095|GO:0097553|GO:0006875|GO:0046873|GO:0038127|GO:0007173|GO:0006874|GO:0006816|GO:0007202|GO:0055074|GO:0015085|GO:0051480|GO:0032469|GO:0070509|GO:0060401|GO:0007204 developmental process|macromolecular complex|signal transducer activity|transporter activity|immune system process|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|transmembrane transporter activity|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|response to stress|receptor signaling protein activity|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|membrane-bounded organelle|lipid binding|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|protein serine/threonine phosphatase complex|positive regulation of immune system process|channel regulator activity|intracellular|regulation of immune system process|endoplasmic reticulum membrane|protein binding|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|regulation of cellular localization|immune response-activating signal transduction|regulation of sequestering of calcium ion|coagulation|post-embryonic development|innate immune response|organelle inner membrane|transport|multicellular organism development|anion binding|platelet dense tubular network membrane|energy derivation by oxidation of organic compounds|small molecule metabolic process|secretion by cell|defense response|phospholipid binding|vesicle|cellular response to stress|calcium-release channel activity|secretory granule|intracellular membrane-bounded organelle|calcium-release channel activity|transmembrane signaling receptor activity|cytoplasm|activation of innate immune response|cell-cell signaling|response to wounding|calcineurin complex|calcium channel regulator activity|regulation of protein localization|vesicle membrane|nuclear envelope|homeostatic process|cell activation|regulation of signal transduction|establishment of protein localization|regulation of hormone secretion|cellular homeostasis|postsynaptic density|substrate-specific transmembrane transporter activity|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|protein localization|cell communication|transmembrane transport|signal transduction|positive regulation of immune response|endoplasmic reticulum|negative regulation of signal transduction|establishment of localization in cell|regulation of ion homeostasis|secretory granule membrane|cell death|response to hypoxia|nuclear membrane|regulation of catalytic activity|generation of precursor metabolites and energy|sequestering of metal ion|regulation of hormone levels|integral component of membrane|response to organic substance|channel inhibitor activity|regulation of body fluid levels|oxidation-reduction process|response to fibroblast growth factor|vesicle-mediated transport|nucleolus|phagocytosis|platelet activation|sarcoplasm|cell surface receptor signaling pathway|regulation of peptide hormone secretion|innate immune response-activating signal transduction|cytoplasmic vesicle|positive regulation of hydrolase activity|calcium channel inhibitor activity|chemical homeostasis|phosphatidylinositol binding|blood coagulation|regulation of protein transport|protein transport|platelet dense granule|sequestering of calcium ion|cytoplasmic, membrane-bounded vesicle|ion channel inhibitor activity|regulation of establishment of protein localization|wound healing|channel activity|intracellular transport|amide transport|epithelial fluid transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|immune response-activating cell surface receptor signaling pathway|ion transmembrane transporter activity|nuclear inner membrane|regulation of secretion|nuclear lumen|platelet dense tubular network|hemostasis|cellular response to fibroblast growth factor stimulus|hormone transport|protein secretion|response to growth factor|membrane-bounded vesicle|immune response-regulating signaling pathway|energy reserve metabolic process|programmed cell death|intracellular signal transduction|cytoplasmic vesicle membrane|secretion|cellular response to organic substance|negative regulation of intracellular signal transduction|platelet dense granule membrane|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|regulation of intracellular signal transduction|response to endoplasmic reticulum stress|musculoskeletal movement|nucleus|sarcoplasmic reticulum|Fc-gamma receptor signaling pathway involved in phagocytosis|positive regulation of innate immune response|apoptotic signaling pathway|regulation of innate immune response|fluid transport|ion transmembrane transport|regulation of insulin secretion|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|peptide secretion|ligand-gated ion channel activity|intrinsic apoptotic signaling pathway|insulin secretion|cation transmembrane transport|ion channel activity|fibroblast growth factor receptor signaling pathway|cation transport|voluntary musculoskeletal movement|regulation of protein secretion|cellular response to growth factor stimulus|peptide transport|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|calcium ion transport into cytosol|enzyme linked receptor protein signaling pathway|ion homeostasis|negative regulation of calcium-mediated signaling|Fc receptor mediated stimulatory signaling pathway|endocytosis|second-messenger-mediated signaling|regulation of calcium-mediated signaling|hormone secretion|positive regulation of lipase activity|apoptotic process|cellular ion homeostasis|cation transmembrane transporter activity|neurotrophin TRK receptor signaling pathway|peptide hormone secretion|stimulatory C-type lectin receptor signaling pathway|regulation of phospholipase activity|Fc receptor signaling pathway|inorganic cation transmembrane transporter activity|metal ion transport|calcium-mediated signaling|inositol phosphate-mediated signaling|cation channel activity|positive regulation of phospholipase activity|cellular cation homeostasis|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|calcium channel activity|positive regulation of phospholipase C activity|Fc-gamma receptor signaling pathway|calcium ion transmembrane transport|metal ion homeostasis|Fc-epsilon receptor signaling pathway|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|metal ion transmembrane transporter activity|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|cellular calcium ion homeostasis|calcium ion transport|activation of phospholipase C activity|calcium ion homeostasis|calcium ion transmembrane transporter activity|regulation of cytosolic calcium ion concentration|endoplasmic reticulum calcium ion homeostasis|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K04958 inositol 1,4,5-triphosphate receptor type 1[-] hsa05205|hsa05016|hsa04020|hsa05010|hsa04022|hsa04921|hsa04210|hsa04728|hsa04611|hsa04114|hsa04270|hsa04724|hsa04726|hsa04725|hsa04922|hsa04723|hsa04915|hsa04750|hsa04070|hsa04972|hsa04713|hsa04912|hsa04970|hsa04540|hsa04925|hsa04971|hsa04918|hsa04720|hsa04924|hsa04730 Proteoglycans in cancer - Homo sapiens (human)|Huntington,s disease - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|Oocyte meiosis - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|GnRH signaling pathway - Homo sapiens (human)|Salivary secretion - Homo sapiens (human)|Gap junction - Homo sapiens (human)|Aldosterone synthesis and secretion - Homo sapiens (human)|Gastric acid secretion - Homo sapiens (human)|Thyroid hormone synthesis - Homo sapiens (human)|Long-term potentiation - Homo sapiens (human)|Renin secretion - Homo sapiens (human)|Long-term depression - Homo sapiens (human) 3:4493348-4847840 46 97 105 138 168 283 0.181912920976876 0.34862742362205 0.374379638216055 0.488971715138534 0.545113070780344 1.04887309189118 0.30163999427166 0.694319292603353 -1.2027715318476 0.00168569588135368 0.00927304376513737 DOWN ENSG00000273301 RP11-314B1.2 - - - - - - - 2:225698514-225703654 20 18 41 53 80 59 0.275187224258354 0.225086838635139 0.50861700239927 0.653392143716042 0.903147652379783 0.760815521209527 0.336297021764254 0.772451772435117 -1.19970885956626 0.0016856973441884 0.00927304376513737 DOWN ENSG00000105695 MAG myelin associated glycoprotein [Source:HGNC Symbol;Acc:HGNC:6783] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0043218|GO:0043220|GO:0048523|GO:0050794|GO:0006950|GO:0043209|GO:0050900|GO:0009628|GO:0035749|GO:0048870|GO:0009653|GO:0016043|GO:0030246|GO:0007155|GO:0071944|GO:0009605|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0050817|GO:0045595|GO:0048468|GO:0009612|GO:0031643|GO:0097453|GO:0031641|GO:0007275|GO:0045596|GO:0048513|GO:0048857|GO:0050877|GO:0005102|GO:0051128|GO:0007420|GO:0045597|GO:0019899|GO:0005737|GO:0009611|GO:0060322|GO:0006928|GO:0043005|GO:0030901|GO:0007154|GO:0016477|GO:0007165|GO:0030030|GO:0048869|GO:0016021|GO:0010033|GO:0050878|GO:0050768|GO:0033270|GO:0000902|GO:0031175|GO:0031344|GO:0007166|GO:0030424|GO:0007417|GO:0010720|GO:0007596|GO:0010721|GO:0000904|GO:0021762|GO:0042060|GO:0044304|GO:0031345|GO:0050769|GO:0007599|GO:0031644|GO:0070848|GO:0022604|GO:0019900|GO:0032990|GO:0007399|GO:0071310|GO:0071260|GO:0030154|GO:0048858|GO:0051960|GO:0008366|GO:0048666|GO:0030182|GO:0010975|GO:0010001|GO:0010769|GO:0071363|GO:0038179|GO:0061564|GO:0007167|GO:0014015|GO:0042552|GO:0045665|GO:0019901|GO:0022008|GO:0048667|GO:0050767|GO:0048812|GO:0010977|GO:0048708|GO:0050771|GO:0048011|GO:0048710|GO:0007409|GO:0048699|GO:0014013|GO:0045685|GO:0048711|GO:0045687|GO:0042063|GO:0050770|GO:0045664|GO:0007169 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|cell projection|compact myelin|Schmidt-Lanterman incisure|negative regulation of cellular process|regulation of cellular process|response to stress|myelin sheath|leukocyte migration|response to abiotic stimulus|myelin sheath adaxonal region|cell motility|anatomical structure morphogenesis|cellular component organization|carbohydrate binding|cell adhesion|cell periphery|response to external stimulus|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|anatomical structure development|coagulation|regulation of cell differentiation|cell development|response to mechanical stimulus|positive regulation of myelination|mesaxon|regulation of myelination|multicellular organism development|negative regulation of cell differentiation|animal organ development|neural nucleus development|neurological system process|receptor binding|regulation of cellular component organization|brain development|positive regulation of cell differentiation|enzyme binding|cytoplasm|response to wounding|head development|movement of cell or subcellular component|neuron projection|midbrain development|cell communication|cell migration|signal transduction|cell projection organization|cellular developmental process|integral component of membrane|response to organic substance|regulation of body fluid levels|negative regulation of neurogenesis|paranode region of axon|cell morphogenesis|neuron projection development|regulation of cell projection organization|cell surface receptor signaling pathway|axon|central nervous system development|positive regulation of cell development|blood coagulation|negative regulation of cell development|cell morphogenesis involved in differentiation|substantia nigra development|wound healing|main axon|negative regulation of cell projection organization|positive regulation of neurogenesis|hemostasis|regulation of neurological system process|response to growth factor|regulation of cell morphogenesis|kinase binding|cell part morphogenesis|nervous system development|cellular response to organic substance|cellular response to mechanical stimulus|cell differentiation|cell projection morphogenesis|regulation of nervous system development|axon ensheathment|neuron development|neuron differentiation|regulation of neuron projection development|glial cell differentiation|regulation of cell morphogenesis involved in differentiation|cellular response to growth factor stimulus|neurotrophin signaling pathway|axon development|enzyme linked receptor protein signaling pathway|positive regulation of gliogenesis|myelination|negative regulation of neuron differentiation|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|regulation of neurogenesis|neuron projection morphogenesis|negative regulation of neuron projection development|astrocyte differentiation|negative regulation of axonogenesis|neurotrophin TRK receptor signaling pathway|regulation of astrocyte differentiation|axonogenesis|generation of neurons|regulation of gliogenesis|regulation of glial cell differentiation|positive regulation of astrocyte differentiation|positive regulation of glial cell differentiation|gliogenesis|regulation of axonogenesis|regulation of neuron differentiation|transmembrane receptor protein tyrosine kinase signaling pathway K06771 myelin associated glycoprotein[-] hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human) 19:35292125-35313804 22 27 17 52 59 49 0.37928458342884 0.423053273407932 0.264244092070987 0.803235705369562 0.834578940714956 0.791719381918254 0.355527316302586 0.809844676000924 -1.18768482213477 0.00168842711213131 0.00928634911672222 DOWN ENSG00000149571 KIRREL3 kin of IRRE like 3 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:23204] GO:0040011|GO:0032502|GO:0002376|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0042995|GO:0048870|GO:0009653|GO:0016043|GO:0071944|GO:0031224|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0043198|GO:0001822|GO:0048468|GO:0032835|GO:0007275|GO:0048513|GO:0048857|GO:0007420|GO:0072102|GO:0060322|GO:0006928|GO:0043005|GO:0072006|GO:0036477|GO:0016477|GO:0030030|GO:0048869|GO:0016021|GO:0002118|GO:0000902|GO:0031175|GO:0030424|GO:0030097|GO:0007417|GO:0001655|GO:0001764|GO:0072001|GO:0030425|GO:0002121|GO:0032990|GO:0007399|GO:0030154|GO:0048858|GO:0048666|GO:0030182|GO:0021740|GO:0022008|GO:0048812|GO:0048699 locomotion|developmental process|immune system process|behavior|cell|membrane|cellular process|extracellular region|binding|cell projection|cell motility|anatomical structure morphogenesis|cellular component organization|cell periphery|intrinsic component of membrane|immune system development|protein binding|plasma membrane|anatomical structure development|dendritic shaft|kidney development|cell development|glomerulus development|multicellular organism development|animal organ development|neural nucleus development|brain development|glomerulus morphogenesis|head development|movement of cell or subcellular component|neuron projection|nephron development|somatodendritic compartment|cell migration|cell projection organization|cellular developmental process|integral component of membrane|aggressive behavior|cell morphogenesis|neuron projection development|axon|hemopoiesis|central nervous system development|urogenital system development|neuron migration|renal system development|dendrite|inter-male aggressive behavior|cell part morphogenesis|nervous system development|cell differentiation|cell projection morphogenesis|neuron development|neuron differentiation|principal sensory nucleus of trigeminal nerve development|neurogenesis|neuron projection morphogenesis|generation of neurons - - - - 11:126423359-127003460 3 3 5 13 15 14 0.0171460510033078 0.0155834812485925 0.0257599681537162 0.0665631786058191 0.0703344389781618 0.0749831530771415 0.0194965001352055 0.0706269235537075 -1.8570030898766 0.00168886011825337 0.00928701970350635 DOWN ENSG00000168398 BDKRB2 bradykinin receptor B2 [Source:HGNC Symbol;Acc:HGNC:1030] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0004872|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0006955|GO:0009628|GO:0044237|GO:0038023|GO:0023051|GO:0043227|GO:0071944|GO:0023057|GO:0016787|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0019222|GO:0042127|GO:0006810|GO:0010941|GO:0005102|GO:0016788|GO:0006952|GO:0033554|GO:0005887|GO:0043231|GO:0002437|GO:0019899|GO:0004888|GO:0005737|GO:0003012|GO:0035633|GO:0042592|GO:0009966|GO:0046983|GO:0019725|GO:0060548|GO:0042493|GO:0010646|GO:0031226|GO:0007154|GO:0007165|GO:0009968|GO:0043114|GO:0008219|GO:0008285|GO:0001666|GO:0006970|GO:0008217|GO:0016021|GO:0010876|GO:0019538|GO:0031324|GO:0031323|GO:0003013|GO:0005768|GO:0032268|GO:0005829|GO:0007186|GO:0035150|GO:0006936|GO:0007166|GO:0043412|GO:0043069|GO:2001234|GO:0046982|GO:0048878|GO:0009651|GO:0036211|GO:0032269|GO:0071456|GO:0006811|GO:0006954|GO:0055082|GO:0002020|GO:0047484|GO:0045776|GO:0006869|GO:0071470|GO:0001664|GO:0071453|GO:0012501|GO:0016298|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0046903|GO:0002438|GO:1902532|GO:0051246|GO:0008528|GO:1902531|GO:0008015|GO:0004930|GO:0042578|GO:0043067|GO:0097190|GO:0004620|GO:0097193|GO:0006820|GO:0015711|GO:2001242|GO:1901797|GO:0006939|GO:0008081|GO:0008627|GO:0072331|GO:2001243|GO:0031690|GO:1902219|GO:0016310|GO:0002526|GO:0015908|GO:0019229|GO:0046942|GO:0007167|GO:0004947|GO:1901796|GO:0042981|GO:0050801|GO:0043066|GO:0006464|GO:0031701|GO:0046717|GO:0006915|GO:0006873|GO:0050880|GO:0036294|GO:0031698|GO:0015718|GO:0004629|GO:0072332|GO:0006468|GO:0042311|GO:0042325|GO:0001932|GO:0042310|GO:0018193|GO:0042326|GO:1902239|GO:0001933|GO:1902254|GO:1902253|GO:0031702|GO:0030003|GO:0007169|GO:0015909|GO:0033137|GO:0004435|GO:0055065|GO:0050482|GO:0006875|GO:0018105|GO:0033135|GO:0006874|GO:0055074|GO:0051480|GO:0007204 signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|immune response|response to abiotic stimulus|cellular metabolic process|signaling receptor activity|regulation of signaling|membrane-bounded organelle|cell periphery|negative regulation of signaling|hydrolase activity|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|regulation of metabolic process|regulation of cell proliferation|transport|regulation of cell death|receptor binding|hydrolase activity, acting on ester bonds|defense response|cellular response to stress|integral component of plasma membrane|intracellular membrane-bounded organelle|inflammatory response to antigenic stimulus|enzyme binding|transmembrane signaling receptor activity|cytoplasm|muscle system process|maintenance of blood-brain barrier|homeostatic process|regulation of signal transduction|protein dimerization activity|cellular homeostasis|negative regulation of cell death|response to drug|regulation of cell communication|intrinsic component of plasma membrane|cell communication|signal transduction|negative regulation of signal transduction|regulation of vascular permeability|cell death|negative regulation of cell proliferation|response to hypoxia|response to osmotic stress|regulation of blood pressure|integral component of membrane|lipid localization|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|endosome|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|regulation of tube size|muscle contraction|cell surface receptor signaling pathway|macromolecule modification|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|protein heterodimerization activity|chemical homeostasis|response to salt stress|protein modification process|negative regulation of cellular protein metabolic process|cellular response to hypoxia|ion transport|inflammatory response|cellular chemical homeostasis|protease binding|regulation of response to osmotic stress|negative regulation of blood pressure|lipid transport|cellular response to osmotic stress|G-protein coupled receptor binding|cellular response to oxygen levels|programmed cell death|lipase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|secretion|acute inflammatory response to antigenic stimulus|negative regulation of intracellular signal transduction|regulation of protein metabolic process|G-protein coupled peptide receptor activity|regulation of intracellular signal transduction|blood circulation|G-protein coupled receptor activity|phosphoric ester hydrolase activity|regulation of programmed cell death|apoptotic signaling pathway|phospholipase activity|intrinsic apoptotic signaling pathway|anion transport|organic anion transport|regulation of intrinsic apoptotic signaling pathway|negative regulation of signal transduction by p53 class mediator|smooth muscle contraction|phosphoric diester hydrolase activity|intrinsic apoptotic signaling pathway in response to osmotic stress|signal transduction by p53 class mediator|negative regulation of intrinsic apoptotic signaling pathway|adrenergic receptor binding|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|phosphorylation|acute inflammatory response|fatty acid transport|regulation of vasoconstriction|carboxylic acid transport|enzyme linked receptor protein signaling pathway|bradykinin receptor activity|regulation of signal transduction by p53 class mediator|regulation of apoptotic process|ion homeostasis|negative regulation of apoptotic process|cellular protein modification process|angiotensin receptor binding|acid secretion|apoptotic process|cellular ion homeostasis|regulation of blood vessel size|cellular response to decreased oxygen levels|beta-2 adrenergic receptor binding|monocarboxylic acid transport|phospholipase C activity|intrinsic apoptotic signaling pathway by p53 class mediator|protein phosphorylation|vasodilation|regulation of phosphorylation|regulation of protein phosphorylation|vasoconstriction|peptidyl-amino acid modification|negative regulation of phosphorylation|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator|negative regulation of protein phosphorylation|negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator|regulation of intrinsic apoptotic signaling pathway by p53 class mediator|type 1 angiotensin receptor binding|cellular cation homeostasis|transmembrane receptor protein tyrosine kinase signaling pathway|long-chain fatty acid transport|negative regulation of peptidyl-serine phosphorylation|phosphatidylinositol phospholipase C activity|metal ion homeostasis|arachidonic acid secretion|cellular metal ion homeostasis|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K03916 bradykinin receptor B2[-] hsa05200|hsa04080|hsa04810|hsa04020|hsa04022|hsa04071|hsa05142|hsa04750|hsa04610|hsa04961 Pathways in cancer - Homo sapiens (human)|Neuroactive ligand-receptor interaction - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Sphingolipid signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human)|Complement and coagulation cascades - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) 14:96204679-96244166 4 3 6 14 8 45 0.022868917862323 0.0155910387079759 0.0309301901050987 0.0717209777316267 0.0375308322525073 0.241126020509968 0.0231300488917992 0.116792610164701 -2.3361087726312 0.00169508911639681 0.00931784026531218 DOWN ENSG00000272733 KB-208E9.1 - - - - - - - 22:23580880-23583859 8 16 14 3 5 4 0.523467625888363 0.951523435027855 0.825987722436623 0.175865401215987 0.268455037209894 0.245275653571575 0.76699292778428 0.229865363999152 1.73842417727621 0.00170425938144181 0.00936307684460137 UP ENSG00000117425 PTCH2 patched 2 [Source:HGNC Symbol;Acc:HGNC:9586] GO:0032502|GO:0004871|GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0050794|GO:0038023|GO:0023051|GO:0023057|GO:0031224|GO:0050793|GO:0005515|GO:0048856|GO:0045595|GO:0009888|GO:0045684|GO:0007275|GO:0048513|GO:0005102|GO:0045597|GO:0004888|GO:0009966|GO:0097108|GO:0010646|GO:0007154|GO:0007165|GO:0009968|GO:0048869|GO:0016021|GO:0045682|GO:0008158|GO:0007166|GO:0001709|GO:0008589|GO:0045879|GO:0030856|GO:0001708|GO:0030858|GO:0043588|GO:0060429|GO:0045606|GO:0005119|GO:0030154|GO:0045165|GO:0042633|GO:0009957|GO:0030855|GO:0007224|GO:0008544|GO:0045604|GO:0009913 developmental process|signal transducer activity|signaling|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|regulation of cellular process|signaling receptor activity|regulation of signaling|negative regulation of signaling|intrinsic component of membrane|regulation of developmental process|protein binding|anatomical structure development|regulation of cell differentiation|tissue development|positive regulation of epidermis development|multicellular organism development|animal organ development|receptor binding|positive regulation of cell differentiation|transmembrane signaling receptor activity|regulation of signal transduction|hedgehog family protein binding|regulation of cell communication|cell communication|signal transduction|negative regulation of signal transduction|cellular developmental process|integral component of membrane|regulation of epidermis development|hedgehog receptor activity|cell surface receptor signaling pathway|cell fate determination|regulation of smoothened signaling pathway|negative regulation of smoothened signaling pathway|regulation of epithelial cell differentiation|cell fate specification|positive regulation of epithelial cell differentiation|skin development|epithelium development|positive regulation of epidermal cell differentiation|smoothened binding|cell differentiation|cell fate commitment|hair cycle|epidermal cell fate specification|epithelial cell differentiation|smoothened signaling pathway|epidermis development|regulation of epidermal cell differentiation|epidermal cell differentiation K11101 patched 2[-] hsa05200|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 1:44819844-44843063 29 36 53 22 16 19 0.385668869509331 0.435108643513161 0.635483480596956 0.262138492035781 0.174582589191033 0.236805827350526 0.485420331206483 0.22450896952578 1.11246145087488 0.00170844124804713 0.00938432475054261 UP ENSG00000251474 RPL32P3 ribosomal protein L32 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:27024] - - - - - - 3:129382922-129399655 80 51 191 246 231 322 0.897249100943205 0.519848236989125 1.93139488881885 2.47204325282781 2.12570056082006 3.38460276647225 1.11616407558373 2.66078219337337 -1.25330130065532 0.00171179219051022 0.0093975439601861 DOWN ENSG00000175267 VWA3A von Willebrand factor A domain containing 3A [Source:HGNC Symbol;Acc:HGNC:27088] GO:0005576 extracellular region - - - - 16:22092538-22156966 12 22 19 2 4 11 0.131873390760739 0.219717359909823 0.188247570880952 0.0196926682015954 0.0360628658753368 0.113284715846714 0.179946107183838 0.0563467499745487 1.67516058777111 0.00171686844622428 0.00942194680029039 UP ENSG00000106610 STAG3L4 stromal antigen 3-like 4 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:33887] - - - - - - 7:67302621-67321526 41 49 26 89 101 83 0.96385567738352 1.04689538934273 0.551067664859027 1.87462133149823 1.94809858646279 1.82865471381011 0.853939577195092 1.88379154392371 -1.14143343166057 0.00174054627786177 0.00954178156253482 DOWN ENSG00000145687 SSBP2 single-stranded DNA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:15831] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0003697|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|single-stranded DNA binding|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 5:81413021-81751797 18 9 57 75 71 122 0.0605166537079786 0.0275007672704133 0.17277798675295 0.225922226710194 0.195850161438788 0.38440343016099 0.086931802577114 0.268725272769991 -1.62817604359609 0.00174062244220421 0.00954178156253482 DOWN ENSG00000261317 RP11-566K11.5 - - - - - - - 16:89969791-89972544 4 6 1 0 0 0 0.1489127641014 0.203012532881272 0.0335498304314971 0 0 0 0.128491709138056 0 Inf 0.00175361897890297 0.00960420858487786 UP ENSG00000074370 ATP2A3 ATPase, Ca++ transporting, ubiquitous [Source:HGNC Symbol;Acc:HGNC:813] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0006950|GO:0042175|GO:0043167|GO:0043227|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0050817|GO:0006810|GO:0033017|GO:0043168|GO:0031095|GO:0001882|GO:0016817|GO:0005887|GO:0043231|GO:0043169|GO:0005737|GO:0009611|GO:0005635|GO:0042592|GO:0019725|GO:0022891|GO:0031226|GO:0055085|GO:0005783|GO:0031965|GO:0000166|GO:0016021|GO:0050878|GO:0016820|GO:0016528|GO:0046872|GO:0035639|GO:0048878|GO:0007596|GO:0001883|GO:0016818|GO:0042060|GO:0006811|GO:0032549|GO:0055082|GO:0015075|GO:0031094|GO:0007599|GO:0017076|GO:0005634|GO:0016529|GO:0034220|GO:0098655|GO:0005524|GO:0006812|GO:0030554|GO:0042625|GO:0050801|GO:0042626|GO:0016462|GO:0006873|GO:0008324|GO:0019829|GO:0017111|GO:0022890|GO:0030001|GO:0030003|GO:0005388|GO:0016887|GO:0070588|GO:0055065|GO:0006875|GO:0046873|GO:0042623|GO:0006874|GO:0006816|GO:0055074|GO:0015085|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|membrane-bounded organelle|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|coagulation|transport|sarcoplasmic reticulum membrane|anion binding|platelet dense tubular network membrane|nucleoside binding|hydrolase activity, acting on acid anhydrides|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to wounding|nuclear envelope|homeostatic process|cellular homeostasis|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|endoplasmic reticulum|nuclear membrane|nucleotide binding|integral component of membrane|regulation of body fluid levels|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|sarcoplasm|metal ion binding|purine ribonucleoside triphosphate binding|chemical homeostasis|blood coagulation|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|wound healing|ion transport|ribonucleoside binding|cellular chemical homeostasis|ion transmembrane transporter activity|platelet dense tubular network|hemostasis|purine nucleotide binding|nucleus|sarcoplasmic reticulum|ion transmembrane transport|cation transmembrane transport|ATP binding|cation transport|adenyl nucleotide binding|ATPase coupled ion transmembrane transporter activity|ion homeostasis|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|cellular ion homeostasis|cation transmembrane transporter activity|cation-transporting ATPase activity|nucleoside-triphosphatase activity|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|calcium-transporting ATPase activity|ATPase activity|calcium ion transmembrane transport|metal ion homeostasis|cellular metal ion homeostasis|metal ion transmembrane transporter activity|ATPase activity, coupled|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|calcium ion transmembrane transporter activity|ATPase activity, coupled to movement of substances K05853 Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum[3.6.3.8] hsa04020|hsa05010|hsa04022|hsa04972 Calcium signaling pathway - Homo sapiens (human)|Alzheimer,s disease - Homo sapiens (human)|cGMP-PKG signaling pathway - Homo sapiens (human)|Pancreatic secretion - Homo sapiens (human) 17:3923870-3964464 206 198 427 446 497 827 1.12584227588743 0.983457143757688 2.10403518078362 2.18395259904718 2.22861671488461 4.23589755612395 1.40444486680958 2.88282229001858 -1.03748191460968 0.00176496787496136 0.0096575056706555 DOWN ENSG00000255495 AC145124.2 - - - - - - - 8:12194467-12196280 3 5 2 15 9 19 0.155939617427586 0.236199070575472 0.0937223394514526 0.698516333575678 0.383788804455135 0.92547406001282 0.16195367581817 0.669259732681211 -2.04698500139147 0.00176475598241702 0.0096575056706555 DOWN ENSG00000203943 SAMD13 sterile alpha motif domain containing 13 [Source:HGNC Symbol;Acc:HGNC:24582] GO:0005488|GO:0005515 binding|protein binding - - - - 1:84298366-84389957 4 6 16 26 30 23 0.0378406114474602 0.0515880450012594 0.136478377952042 0.220387595234139 0.232866289955121 0.203929877482777 0.0753023448002539 0.219061254224012 -1.5405676406728 0.00176632818212593 0.00966317785398343 DOWN ENSG00000137968 SLC44A5 solute carrier family 44 member 5 [Source:HGNC Symbol;Acc:HGNC:28524] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0006807|GO:0071704|GO:0044237|GO:0071944|GO:0009058|GO:0031224|GO:0005886|GO:0044255|GO:0006810|GO:0034641|GO:0044281|GO:0019637|GO:0055085|GO:0006629|GO:0016021|GO:0044249|GO:0008654|GO:0046486|GO:0006066|GO:0009308|GO:0046470|GO:0006796|GO:0008610|GO:0006644|GO:0006656|GO:0046474|GO:0006576|GO:0006650 cell|membrane|cellular process|metabolic process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell periphery|biosynthetic process|intrinsic component of membrane|plasma membrane|cellular lipid metabolic process|transport|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|transmembrane transport|lipid metabolic process|integral component of membrane|cellular biosynthetic process|phospholipid biosynthetic process|glycerolipid metabolic process|alcohol metabolic process|amine metabolic process|phosphatidylcholine metabolic process|phosphate-containing compound metabolic process|lipid biosynthetic process|phospholipid metabolic process|phosphatidylcholine biosynthetic process|glycerophospholipid biosynthetic process|cellular biogenic amine metabolic process|glycerophospholipid metabolic process K15377 solute carrier family 44 (choline transporter-like protein), member 2/4/5[-] hsa05231 Choline metabolism in cancer - Homo sapiens (human) 1:75202131-75611116 0 0 4 7 5 19 0 0 0.0392903446768603 0.0683249513540459 0.0446942700175413 0.193988941271746 0.0130967815589534 0.102336054214444 -2.96603028496776 0.00178281838260965 0.00974267984521847 DOWN ENSG00000247317 RP11-273G15.2 - - - - - - - 8:142981738-143018437 44 61 81 109 120 167 0.593518171551689 0.74781766809327 0.985098272473198 1.31737004584341 1.32810163996525 2.11119943041323 0.775478037372719 1.58555703874063 -1.03183195000379 0.00178329834072027 0.00974351915517257 DOWN ENSG00000133138 TBC1D8B TBC1 domain family member 8B [Source:HGNC Symbol;Acc:HGNC:24715] GO:0008152|GO:0005488|GO:0043167|GO:0009893|GO:0030234|GO:0019222|GO:0008047|GO:0043169|GO:0043085|GO:0050790|GO:0005096|GO:0046872|GO:0051345|GO:0030695|GO:0043087|GO:0005509|GO:0043547 metabolic process|binding|ion binding|positive regulation of metabolic process|enzyme regulator activity|regulation of metabolic process|enzyme activator activity|cation binding|positive regulation of catalytic activity|regulation of catalytic activity|GTPase activator activity|metal ion binding|positive regulation of hydrolase activity|GTPase regulator activity|regulation of GTPase activity|calcium ion binding|positive regulation of GTPase activity - - - - X:106802680-106876145 74 103 166 192 212 371 0.447320859849582 0.565853917176724 0.904707711334771 1.03988540345582 1.05145404248246 2.10178723911734 0.639294162787026 1.39770889501854 -1.12851209144282 0.0017946683729157 0.00979968052667253 DOWN ENSG00000264177 RP1-37N7.1 - - - - - - - 17:18379855-18388984 20 37 28 14 12 12 0.285517158408113 0.480052593659625 0.360387226549796 0.179078090110128 0.140558652728065 0.160544795415342 0.375318992872511 0.160060512751178 1.22949986310121 0.00179489023647904 0.00979968052667253 UP ENSG00000272320 RP11-506K6.4 - - - - - - - 6:3311662-3313650 2 3 1 9 4 37 0.0711247490680393 0.0969795529889785 0.0320486062442657 0.286775070063092 0.116710240140545 1.23320997786686 0.0667176361004278 0.545565096023499 -3.03161126897752 0.00180106047102879 0.00982618042801417 DOWN ENSG00000140543 DET1 de-etiolated homolog 1 (Arabidopsis) [Source:HGNC Symbol;Acc:HGNC:25477] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus K10571 de-etiolated-1[-] hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) 15:88511559-88546675 23 41 36 71 71 78 0.311859562819847 0.505234772838742 0.440088772000757 0.862541736544978 0.789857657019761 0.991167872381757 0.419061035886449 0.881189088648832 -1.07229124438888 0.00180786329259127 0.00986082497588557 DOWN ENSG00000181035 SLC25A42 solute carrier family 25 member 42 [Source:HGNC Symbol;Acc:HGNC:28380] GO:0005215|GO:0005198|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0022857|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0003735|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0006810|GO:0034641|GO:0016817|GO:0043231|GO:0005737|GO:0031966|GO:0022891|GO:0055085|GO:0005337|GO:0016021|GO:0044249|GO:0019538|GO:1901642|GO:0005740|GO:0034645|GO:0006518|GO:1901679|GO:0015228|GO:0080122|GO:0016818|GO:0051181|GO:0006811|GO:0005347|GO:0015075|GO:0005743|GO:0015211|GO:0005739|GO:0043603|GO:0044267|GO:0010467|GO:0009059|GO:1901264|GO:0005634|GO:0015217|GO:0015932|GO:0034220|GO:0015858|GO:0043043|GO:0006820|GO:0015711|GO:0015868|GO:0098656|GO:0015860|GO:0008509|GO:0006812|GO:0006412|GO:0015695|GO:0016462|GO:0008324|GO:0017110|GO:0080121|GO:0035349|GO:0015101|GO:0008514|GO:0015866|GO:0015216|GO:0015867|GO:0015865|GO:0051503|GO:0043262 transporter activity|structural molecule activity|cell|membrane|cellular process|metabolic process|catalytic activity|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|structural constituent of ribosome|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|transport|cellular nitrogen compound metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|substrate-specific transmembrane transporter activity|transmembrane transport|nucleoside transmembrane transporter activity|integral component of membrane|cellular biosynthetic process|protein metabolic process|nucleoside transmembrane transport|mitochondrial envelope|cellular macromolecule biosynthetic process|peptide metabolic process|nucleotide transmembrane transport|coenzyme A transmembrane transporter activity|AMP transmembrane transporter activity|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cofactor transport|ion transport|ATP transmembrane transporter activity|ion transmembrane transporter activity|mitochondrial inner membrane|purine nucleoside transmembrane transporter activity|mitochondrion|cellular amide metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|carbohydrate derivative transport|nucleus|ADP transmembrane transporter activity|nucleobase-containing compound transmembrane transporter activity|ion transmembrane transport|nucleoside transport|peptide biosynthetic process|anion transport|organic anion transport|purine ribonucleotide transport|anion transmembrane transport|purine nucleoside transmembrane transport|anion transmembrane transporter activity|cation transport|translation|organic cation transport|pyrophosphatase activity|cation transmembrane transporter activity|nucleoside-diphosphatase activity|AMP transport|coenzyme A transmembrane transport|organic cation transmembrane transporter activity|organic anion transmembrane transporter activity|ADP transport|purine nucleotide transmembrane transporter activity|ATP transport|purine nucleotide transport|adenine nucleotide transport|adenosine-diphosphatase activity - - - - 19:19063999-19112888 18 16 106 125 144 212 0.237108080822322 0.191545034127581 1.25889632524961 1.47529200072628 1.55633170363369 2.6171957055561 0.562516480066504 1.88293980330536 -1.74301960965908 0.00180807114349828 0.00986082497588557 DOWN ENSG00000198574 SH2D1B SH2 domain containing 1B [Source:HGNC Symbol;Acc:HGNC:30416] GO:0002376|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0060090|GO:0045321|GO:0006950|GO:0006955|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0045087|GO:0006952|GO:0005737|GO:0001775|GO:0002263|GO:0030674|GO:0050776|GO:0002366|GO:0050778|GO:0002443|GO:0005829|GO:0002228|GO:0045089|GO:0045088|GO:0002715|GO:0002717 immune system process|cell|cellular process|response to stimulus|binding|binding, bridging|leukocyte activation|response to stress|immune response|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|innate immune response|defense response|cytoplasm|cell activation|cell activation involved in immune response|protein binding, bridging|regulation of immune response|leukocyte activation involved in immune response|positive regulation of immune response|leukocyte mediated immunity|cytosol|natural killer cell mediated immunity|positive regulation of innate immune response|regulation of innate immune response|regulation of natural killer cell mediated immunity|positive regulation of natural killer cell mediated immunity K07989 EWS/FLI1 activated transcript 2[-] hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) 1:162395266-162412138 1 0 1 4 5 10 0.0227912056111478 0 0.0205296868985006 0.0816500516674199 0.0934621240656669 0.21350337215059 0.0144402975032161 0.129538515961226 -3.16520875079991 0.00182849122971811 0.00996309128892213 DOWN ENSG00000272654 RP11-422P24.11 - - - - - - - 1:153977743-153979160 25 25 40 13 15 15 1.24713572999117 1.13343651384669 1.79905171474951 0.581043035812996 0.613963106961698 0.701288585448925 1.39320798619579 0.632098242741206 1.14018993868444 0.00184317419250379 0.0100375998436717 UP ENSG00000137270 GCM1 glial cells missing homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:4197] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0019222|GO:0006949|GO:0001890|GO:0060670|GO:0006725|GO:0009888|GO:0060713|GO:0051130|GO:1901360|GO:0060143|GO:0007275|GO:0003676|GO:0048513|GO:0060706|GO:0034641|GO:0031325|GO:0046483|GO:0051128|GO:0043231|GO:0048608|GO:0043169|GO:0019899|GO:0000981|GO:0001763|GO:0060669|GO:0005667|GO:0048729|GO:0048598|GO:0048568|GO:0006139|GO:0001892|GO:0008134|GO:0048869|GO:0044249|GO:0031323|GO:0060711|GO:0000982|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0002009|GO:0061458|GO:0007417|GO:0051252|GO:0061138|GO:0009790|GO:0010628|GO:0042826|GO:0060429|GO:0010467|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0001228|GO:0016070|GO:0010557|GO:0005634|GO:0045165|GO:0000975|GO:0045893|GO:0009792|GO:0010001|GO:0032774|GO:0043565|GO:2001141|GO:0001077|GO:0003690|GO:0021781|GO:0046914|GO:0022008|GO:0048708|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:0060018|GO:1903506|GO:0044212|GO:0042063|GO:0043009|GO:0008270|GO:0000976|GO:0001012|GO:0001701|GO:0001159|GO:0000977|GO:0000987|GO:0000978 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|syncytium formation|placenta development|branching involved in labyrinthine layer morphogenesis|cellular aromatic compound metabolic process|tissue development|labyrinthine layer morphogenesis|positive regulation of cellular component organization|organic cyclic compound metabolic process|positive regulation of syncytium formation by plasma membrane fusion|multicellular organism development|nucleic acid binding|animal organ development|cell differentiation involved in embryonic placenta development|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|intracellular membrane-bounded organelle|reproductive structure development|cation binding|enzyme binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|morphogenesis of a branching structure|embryonic placenta morphogenesis|transcription factor complex|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|nucleobase-containing compound metabolic process|embryonic placenta development|transcription factor binding|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|labyrinthine layer development|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|morphogenesis of an epithelium|reproductive system development|central nervous system development|regulation of RNA metabolic process|morphogenesis of a branching epithelium|embryo development|positive regulation of gene expression|histone deacetylase binding|epithelium development|gene expression|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|cell fate commitment|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|glial cell differentiation|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|double-stranded DNA binding|glial cell fate commitment|transition metal ion binding|neurogenesis|astrocyte differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|astrocyte fate commitment|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|gliogenesis|chordate embryonic development|zinc ion binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|in utero embryonic development|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 6:53126964-53148829 4 15 15 2 0 5 0.102327035006387 0.34876671097429 0.345980978580048 0.0458451013430992 0 0.119891227355874 0.265691574853575 0.0552454428996577 2.26582511120835 0.00184891796012974 0.0100670430023186 UP ENSG00000167912 RP11-25K19.1 - - - - - - - 8:59119040-59121346 32 23 20 14 7 10 0.786794068904789 0.513951467666482 0.443364977384175 0.308422640422553 0.141212453612675 0.230423347420084 0.581370171318482 0.226686147151771 1.35876082190837 0.00185414243820137 0.0100899687112767 UP ENSG00000177453 NIM1K NIM1 serine/threonine protein kinase [Source:HGNC Symbol;Acc:HGNC:28646] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0071704|GO:0043167|GO:0044237|GO:0005622|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0000166|GO:0019538|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0035556|GO:0044267|GO:0017076|GO:0016773|GO:0000287|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0004674 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|organic substance metabolic process|ion binding|cellular metabolic process|intracellular|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cation binding|cytoplasm|cell communication|signal transduction|nucleotide binding|protein metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|magnesium ion binding|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|protein serine/threonine kinase activity - - - - 5:43192071-43280850 9 14 6 2 3 3 0.112718696354096 0.159352377674747 0.0677528880984917 0.0224436446908055 0.0308306588888322 0.0352084341595528 0.113274654042445 0.0294942459130635 1.94131965565669 0.00185523769320713 0.0100940889544388 UP ENSG00000205578 POM121B POM121 transmembrane nucleoporin B (pseudogene) [Source:HGNC Symbol;Acc:HGNC:34004] - - - - - - 7:73293497-73301161 65 72 41 35 29 26 1.84877905305664 1.86115229179453 1.05138721726363 0.891931509417429 0.676750310579046 0.69306028551342 1.5871061873716 0.753914035169965 1.0739267216619 0.00185873323757295 0.0101112649552666 UP ENSG00000274245 RP11-357P18.2 - - - - - - - 1:207372559-207373252 9 6 5 0 3 0 0.917341782432182 0.555798000683598 0.459447962257491 0 0.250910030841677 0 0.644195915124424 0.0836366769472257 2.94529186554105 0.00185989167289365 0.0101138808747845 UP ENSG00000256349 CTD-3074O7.11 - - - - - - - 11:66509079-66533613 0 0 0 0 46 0 0 0 0 0 0.752677203806469 0 0 0.250892401268823 -Inf 0.00186745434005844 0.0101494596519397 DOWN ENSG00000204021 LIPK lipase, family member K [Source:HGNC Symbol;Acc:HGNC:23444] GO:0005576|GO:0008152|GO:0003824|GO:0071704|GO:0009056|GO:0016787|GO:0016788|GO:0006629|GO:0016042 extracellular region|metabolic process|catalytic activity|organic substance metabolic process|catabolic process|hydrolase activity|hydrolase activity, acting on ester bonds|lipid metabolic process|lipid catabolic process - - - - 10:88724544-88752786 3 12 5 14 19 55 0.172547820584507 0.627193191015312 0.259233240493251 0.721408078451777 0.896533620578236 2.96434072868041 0.352991417364357 1.52742747590347 -2.11339886943295 0.00186949284027171 0.0101568406284753 DOWN ENSG00000243207 PPAN-P2RY11 PPAN-P2RY11 readthrough [Source:HGNC Symbol;Acc:HGNC:33526] GO:0004871|GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0031224|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0004930 signal transducer activity|signaling|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|intrinsic component of membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor activity - - - - 19:10106223-10114780 457 159 514 0 86 0 8.36829643765509 2.64605525633702 8.48590499552476 0 1.29207535137038 0 6.50008556317229 0.430691783790127 3.91573100203849 0.00188810302348917 0.0102486232114992 UP ENSG00000146021 KLHL3 kelch like family member 3 [Source:HGNC Symbol;Acc:HGNC:6354] GO:0032502|GO:0032991|GO:0005198|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0009653|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0048856|GO:0003014|GO:0035239|GO:0001822|GO:0009888|GO:0006810|GO:0035295|GO:0007275|GO:0048513|GO:0072028|GO:0003096|GO:0005737|GO:0009887|GO:0042592|GO:0048729|GO:0072006|GO:0008092|GO:0019787|GO:0000151|GO:0019538|GO:0005829|GO:0002009|GO:0043412|GO:0030163|GO:0001655|GO:0004842|GO:0031461|GO:0048878|GO:0003779|GO:0044265|GO:0036211|GO:0072001|GO:0006811|GO:0070294|GO:1990234|GO:0070293|GO:0006508|GO:0061326|GO:0060993|GO:0060429|GO:0072073|GO:0044267|GO:0060562|GO:0005856|GO:0044257|GO:0006812|GO:0072078|GO:0061333|GO:0051603|GO:0072080|GO:0050801|GO:0006464|GO:0031463|GO:0072156|GO:0072017|GO:0019941|GO:0030001|GO:0015672|GO:0032446|GO:0006511|GO:0006814|GO:0042787|GO:0016567|GO:0000209|GO:0070936 developmental process|macromolecular complex|structural molecule activity|cell|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|anatomical structure morphogenesis|intracellular|protein binding|protein complex|transferase activity|anatomical structure development|renal system process|tube morphogenesis|kidney development|tissue development|transport|tube development|multicellular organism development|animal organ development|nephron morphogenesis|renal sodium ion transport|cytoplasm|organ morphogenesis|homeostatic process|tissue morphogenesis|nephron development|cytoskeletal protein binding|ubiquitin-like protein transferase activity|ubiquitin ligase complex|protein metabolic process|cytosol|morphogenesis of an epithelium|macromolecule modification|protein catabolic process|urogenital system development|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|chemical homeostasis|actin binding|cellular macromolecule catabolic process|protein modification process|renal system development|ion transport|renal sodium ion absorption|transferase complex|renal absorption|proteolysis|renal tubule development|kidney morphogenesis|epithelium development|kidney epithelium development|cellular protein metabolic process|epithelial tube morphogenesis|cytoskeleton|cellular protein catabolic process|cation transport|nephron tubule morphogenesis|renal tubule morphogenesis|proteolysis involved in cellular protein catabolic process|nephron tubule development|ion homeostasis|cellular protein modification process|Cul3-RING ubiquitin ligase complex|distal tubule morphogenesis|distal tubule development|modification-dependent protein catabolic process|metal ion transport|monovalent inorganic cation transport|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|sodium ion transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination|protein K48-linked ubiquitination - - - - 5:137617500-137736090 9 12 8 26 22 37 0.0383561391136242 0.0464783482918926 0.0307401142290462 0.0992793137465753 0.0769290224554377 0.147780132906204 0.038524867211521 0.107996156369406 -1.48711807800907 0.00189256298479828 0.0102672315733541 DOWN ENSG00000184828 ZBTB7C zinc finger and BTB domain containing 7C [Source:HGNC Symbol;Acc:HGNC:31700] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0019222|GO:0045595|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0031325|GO:0046483|GO:0051098|GO:0045597|GO:0043231|GO:0043169|GO:0006139|GO:0048869|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051101|GO:0046872|GO:0051252|GO:0010628|GO:0045600|GO:0010467|GO:0045598|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0045444|GO:2000677|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:1903025 developmental process|cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|regulation of metabolic process|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of binding|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of DNA binding|metal ion binding|regulation of RNA metabolic process|positive regulation of gene expression|positive regulation of fat cell differentiation|gene expression|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|fat cell differentiation|regulation of transcription regulatory region DNA binding|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|regulation of RNA polymerase II regulatory region sequence-specific DNA binding - - - - 18:48026673-48410752 0 1 6 10 9 16 0 0.00699942613308732 0.0416441736837829 0.0689747008453964 0.05684367862264 0.115432904510207 0.0162145332722901 0.0804170946594145 -2.31021471772951 0.00190313384864679 0.0103170797017434 DOWN ENSG00000082482 KCNK2 potassium channel, two pore domain subfamily K, member 2 [Source:HGNC Symbol;Acc:HGNC:6277] GO:0032502|GO:0040007|GO:0032991|GO:0005215|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0009892|GO:0022857|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0042175|GO:0071704|GO:0009628|GO:0009986|GO:0044237|GO:0045177|GO:0045926|GO:0044297|GO:0043227|GO:0044708|GO:0071944|GO:0040008|GO:0009605|GO:0009058|GO:0031224|GO:0050793|GO:0048589|GO:0016247|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0007507|GO:0042127|GO:0042391|GO:0090102|GO:0006725|GO:0009888|GO:0043025|GO:0006810|GO:0009612|GO:1901360|GO:0048839|GO:0010941|GO:0016324|GO:0098797|GO:0007275|GO:0048513|GO:0050877|GO:0034641|GO:0046620|GO:1900039|GO:0046483|GO:0033554|GO:0046621|GO:0010942|GO:0035265|GO:0061061|GO:0005887|GO:0055017|GO:0043231|GO:0048635|GO:0005737|GO:0007267|GO:0009611|GO:0007423|GO:0043005|GO:0015459|GO:0009890|GO:0036477|GO:0022891|GO:1901862|GO:0006139|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0005783|GO:0048638|GO:0044306|GO:0008219|GO:0097386|GO:0007611|GO:0008285|GO:0001666|GO:0048640|GO:0071804|GO:0016021|GO:0044249|GO:0031324|GO:0031323|GO:0016248|GO:0003205|GO:0030322|GO:0060043|GO:0007186|GO:0034645|GO:0051053|GO:0030424|GO:0072358|GO:0043583|GO:0048678|GO:0048738|GO:0060420|GO:0008200|GO:0007613|GO:0071456|GO:0060537|GO:0015267|GO:0006811|GO:0045843|GO:0043679|GO:0015075|GO:0008076|GO:0003231|GO:1900037|GO:0034702|GO:0006259|GO:0060044|GO:0071453|GO:0060038|GO:0050890|GO:0071805|GO:0009059|GO:0019870|GO:0007517|GO:0072359|GO:0005634|GO:0097449|GO:0034220|GO:0016202|GO:0055024|GO:0098655|GO:0005216|GO:2000279|GO:0034703|GO:0006812|GO:0044305|GO:2000278|GO:0014706|GO:0071897|GO:0008324|GO:0036294|GO:0055026|GO:0022840|GO:0005244|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0007268|GO:0006813|GO:0022843|GO:0015077|GO:0022841|GO:0046873|GO:0005267|GO:0015079|GO:0005249|GO:0015271 developmental process|growth|macromolecular complex|transporter activity|behavior|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of metabolic process|transmembrane transporter activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|response to abiotic stimulus|cell surface|cellular metabolic process|apical part of cell|negative regulation of growth|cell body|membrane-bounded organelle|single-organism behavior|cell periphery|regulation of growth|response to external stimulus|biosynthetic process|intrinsic component of membrane|regulation of developmental process|developmental growth|channel regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|heart development|regulation of cell proliferation|regulation of membrane potential|cochlea development|cellular aromatic compound metabolic process|tissue development|neuronal cell body|transport|response to mechanical stimulus|organic cyclic compound metabolic process|inner ear development|regulation of cell death|apical plasma membrane|plasma membrane protein complex|multicellular organism development|animal organ development|neurological system process|cellular nitrogen compound metabolic process|regulation of organ growth|positive regulation of cellular response to hypoxia|heterocycle metabolic process|cellular response to stress|negative regulation of organ growth|positive regulation of cell death|organ growth|muscle structure development|integral component of plasma membrane|cardiac muscle tissue growth|intracellular membrane-bounded organelle|negative regulation of muscle organ development|cytoplasm|cell-cell signaling|response to wounding|sensory organ development|neuron projection|potassium channel regulator activity|negative regulation of biosynthetic process|somatodendritic compartment|substrate-specific transmembrane transporter activity|negative regulation of muscle tissue development|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|endoplasmic reticulum|regulation of developmental growth|neuron projection terminus|cell death|glial cell projection|learning or memory|negative regulation of cell proliferation|response to hypoxia|negative regulation of developmental growth|cellular potassium ion transport|integral component of membrane|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|channel inhibitor activity|cardiac chamber development|stabilization of membrane potential|regulation of cardiac muscle cell proliferation|G-protein coupled receptor signaling pathway|cellular macromolecule biosynthetic process|negative regulation of DNA metabolic process|axon|cardiovascular system development|ear development|response to axon injury|cardiac muscle tissue development|regulation of heart growth|ion channel inhibitor activity|memory|cellular response to hypoxia|muscle tissue development|channel activity|ion transport|negative regulation of striated muscle tissue development|axon terminus|ion transmembrane transporter activity|voltage-gated potassium channel complex|cardiac ventricle development|regulation of cellular response to hypoxia|ion channel complex|DNA metabolic process|negative regulation of cardiac muscle cell proliferation|cellular response to oxygen levels|cardiac muscle cell proliferation|cognition|potassium ion transmembrane transport|macromolecule biosynthetic process|potassium channel inhibitor activity|muscle organ development|circulatory system development|nucleus|astrocyte projection|ion transmembrane transport|regulation of striated muscle tissue development|regulation of cardiac muscle tissue development|cation transmembrane transport|ion channel activity|negative regulation of DNA biosynthetic process|cation channel complex|cation transport|calyx of Held|regulation of DNA biosynthetic process|striated muscle tissue development|DNA biosynthetic process|cation transmembrane transporter activity|cellular response to decreased oxygen levels|negative regulation of cardiac muscle tissue development|leak channel activity|voltage-gated ion channel activity|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|synaptic transmission|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|potassium ion leak channel activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity|outward rectifier potassium channel activity K04913 potassium channel subfamily K member 2[-] hsa04971 Gastric acid secretion - Homo sapiens (human) 1:215005775-215237093 7 8 4 18 62 11 0.0724671551458516 0.0752668544757143 0.037335315086617 0.166953201918774 0.52661361536787 0.106719408152393 0.0616897749027276 0.266762075146346 -2.11245028978927 0.00190704658839819 0.0103364140976833 DOWN ENSG00000238109 AC004893.10 - - - - - - - 7:98998538-98999930 15 14 6 4 3 3 0.761691726272021 0.64610353848311 0.27470804880135 0.181998141010293 0.125004710268574 0.14275465623342 0.56083443785216 0.149919169170762 1.90339007734239 0.00190889725435025 0.010344566823629 UP ENSG00000155749 ALS2CR12 amyotrophic lateral sclerosis 2 chromosome region candidate 12 [Source:HGNC Symbol;Acc:HGNC:14439] GO:0005623|GO:0008152|GO:0005488|GO:0042995|GO:0001520|GO:0005622|GO:0005515|GO:0005929|GO:0019222|GO:0036126|GO:0031514|GO:0005737|GO:0035686|GO:0050790|GO:0043087 cell|metabolic process|binding|cell projection|outer dense fiber|intracellular|protein binding|cilium|regulation of metabolic process|sperm flagellum|motile cilium|cytoplasm|sperm fibrous sheath|regulation of catalytic activity|regulation of GTPase activity - - - - 2:201288271-201357398 1 1 4 7 8 15 0.0128666715313843 0.011694132133989 0.0463840378157916 0.0806607107530582 0.0844239012050945 0.180804948030286 0.0236482804937216 0.115296519996146 -2.28554177696373 0.00192616926420413 0.0104305926380464 DOWN ENSG00000213513 RP13-39P12.2 - - - - - - - 10:77780337-77781876 21 27 11 3 8 9 0.964613125542086 1.12713479272256 0.455535842718818 0.123448375788624 0.301513932875338 0.387430016331081 0.849094586994488 0.270797441665014 1.64871116607477 0.00194179655797694 0.0105037859108251 UP ENSG00000260412 RP11-438B23.2 - - - - - - - 9:27937617-27944497 0 0 2 2 8 11 0 0 0.0185374369994807 0.0184219888408181 0.0674802291277459 0.10597496234636 0.00617914566649357 0.0639590601049747 -3.37166944930805 0.00194218442164006 0.0105039807470367 DOWN ENSG00000166446 CDYL2 chromodomain protein, Y-like 2 [Source:HGNC Symbol;Acc:HGNC:23030] GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0042393|GO:0043231|GO:0035064|GO:0005634 cell|metabolic process|binding|catalytic activity|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|histone binding|intracellular membrane-bounded organelle|methylated histone binding|nucleus - - - - 16:80597906-80804329 0 0 1 5 7 3 0 0 0.00625745340334195 0.0311055466700845 0.0398810473194922 0.0195206867707033 0.00208581780111398 0.03016909358676 -3.85438630499066 0.00195376717288985 0.0105608845155629 DOWN ENSG00000261762 RP11-650L12.2 - - - - - - - 15:78589123-78591276 11 11 7 37 42 15 0.361235990206251 0.328315110272811 0.207248370380745 1.08867008780632 1.1316663761662 0.461665373336386 0.298933156953269 0.894000612436302 -1.58045289354257 0.00195711424223658 0.0105770616559976 DOWN ENSG00000224057 EGFR-AS1 EGFR antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40207] - - - - - - 7:55179750-55188934 5 6 25 30 35 47 0.126051655458045 0.137463938871852 0.568217364839975 0.677605652171417 0.723927706777739 1.11042520786 0.277244319723291 0.837319522269719 -1.59462035997755 0.00195875673132541 0.0105840223451563 DOWN ENSG00000156398 SFXN2 sideroflexin 2 [Source:HGNC Symbol;Acc:HGNC:16086] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0019866|GO:0006810|GO:0043231|GO:0005737|GO:0042592|GO:0031966|GO:0022891|GO:0055085|GO:0016021|GO:0005740|GO:0048878|GO:0006811|GO:0015075|GO:0005743|GO:0005739|GO:0034220|GO:0050801|GO:0055065|GO:0055072 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|organelle inner membrane|transport|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|mitochondrial membrane|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|mitochondrial envelope|chemical homeostasis|ion transport|ion transmembrane transporter activity|mitochondrial inner membrane|mitochondrion|ion transmembrane transport|ion homeostasis|metal ion homeostasis|iron ion homeostasis - - - - 10:102714538-102743492 28 46 35 65 97 80 0.15556126480502 0.232266407134558 0.175321901170916 0.323562293741293 0.442168707118048 0.416548404097633 0.187716524370165 0.394093134985658 -1.06998096449074 0.00196186553371843 0.0105989022156406 DOWN ENSG00000113231 PDE8B phosphodiesterase 8B [Source:HGNC Symbol;Acc:HGNC:8794] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0023057|GO:0016787|GO:0005622|GO:0060341|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0016788|GO:0044281|GO:0032940|GO:0019637|GO:0046483|GO:0043169|GO:0005737|GO:0007267|GO:0032880|GO:0045184|GO:0046883|GO:0010646|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0007165|GO:0046888|GO:0051048|GO:1903531|GO:0010817|GO:0051224|GO:0005829|GO:0046872|GO:0090276|GO:0019693|GO:0050709|GO:0051223|GO:0015031|GO:0070201|GO:0042886|GO:0051046|GO:0009914|GO:0009306|GO:0006796|GO:0035556|GO:0002792|GO:0046903|GO:0019439|GO:0046434|GO:0042578|GO:0050796|GO:0002790|GO:0030073|GO:0008081|GO:0009259|GO:0046676|GO:0009117|GO:0050708|GO:0015833|GO:0000160|GO:0006163|GO:0009166|GO:0046879|GO:0030072|GO:0006195|GO:0004112|GO:0009154|GO:0009187|GO:0009214|GO:0046058|GO:0004114|GO:0006198 signaling|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|negative regulation of signaling|hydrolase activity|intracellular|regulation of cellular localization|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|secretion by cell|organophosphate metabolic process|heterocycle metabolic process|cation binding|cytoplasm|cell-cell signaling|regulation of protein localization|establishment of protein localization|regulation of hormone secretion|regulation of cell communication|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|signal transduction|negative regulation of hormone secretion|negative regulation of secretion|negative regulation of secretion by cell|regulation of hormone levels|negative regulation of protein transport|cytosol|metal ion binding|regulation of peptide hormone secretion|ribose phosphate metabolic process|negative regulation of protein secretion|regulation of protein transport|protein transport|regulation of establishment of protein localization|amide transport|regulation of secretion|hormone transport|protein secretion|phosphate-containing compound metabolic process|intracellular signal transduction|negative regulation of peptide secretion|secretion|aromatic compound catabolic process|organophosphate catabolic process|phosphoric ester hydrolase activity|regulation of insulin secretion|peptide secretion|insulin secretion|phosphoric diester hydrolase activity|ribonucleotide metabolic process|negative regulation of insulin secretion|nucleotide metabolic process|regulation of protein secretion|peptide transport|phosphorelay signal transduction system|purine nucleotide metabolic process|nucleotide catabolic process|hormone secretion|peptide hormone secretion|purine nucleotide catabolic process|cyclic-nucleotide phosphodiesterase activity|purine ribonucleotide catabolic process|cyclic nucleotide metabolic process|cyclic nucleotide catabolic process|cAMP metabolic process|3',5'-cyclic-nucleotide phosphodiesterase activity|cAMP catabolic process K18437 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8[3.1.4.53] hsa00230|hsa05032 Purine metabolism - Homo sapiens (human)|Morphine addiction - Homo sapiens (human) 5:77210449-77429807 8 5 4 16 25 18 0.0528355278791149 0.0300155868397028 0.023820000745738 0.0946806277775266 0.135475383265224 0.111417782474298 0.0355570384881852 0.11385793117235 -1.67902771735255 0.00196632055043457 0.0106191269378932 DOWN ENSG00000267272 LINC01140 long intergenic non-protein coding RNA 1140 [Source:HGNC Symbol;Acc:HGNC:27922] - - - - - - 1:87129765-87169198 1 1 1 10 5 6 0.00485168609780707 0.00440955208672284 0.00437026448785441 0.0434532103433667 0.0198957833006922 0.0272716981363438 0.00454383422412811 0.0302068972601342 -2.73289589735386 0.00196674179633931 0.01061948084426 DOWN ENSG00000115596 WNT6 wingless-type MMTV integration site family member 6 [Source:HGNC Symbol;Acc:HGNC:12785] GO:0032502|GO:0031012|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0005578|GO:0006807|GO:0071704|GO:0009986|GO:0044237|GO:0009653|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0005615|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0019222|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0035295|GO:1901360|GO:0007275|GO:0048513|GO:0072028|GO:0005102|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0061303|GO:0070169|GO:0043231|GO:0005737|GO:0007389|GO:0001763|GO:0007267|GO:0007423|GO:0012506|GO:0009887|GO:0030666|GO:0048729|GO:0048598|GO:0072006|GO:0034505|GO:0006139|GO:0007154|GO:0035148|GO:0007165|GO:0005783|GO:0070062|GO:0042482|GO:0048869|GO:0044249|GO:0010033|GO:0031323|GO:0005794|GO:0010468|GO:0034645|GO:0007166|GO:0001654|GO:0002009|GO:0033993|GO:0072164|GO:0031410|GO:0001655|GO:0009798|GO:0051252|GO:0048754|GO:0061138|GO:0031214|GO:0009790|GO:0010628|GO:0016023|GO:0072175|GO:0070172|GO:2000027|GO:0072001|GO:0005796|GO:0016331|GO:0031988|GO:0001664|GO:0060684|GO:0061326|GO:0060993|GO:0060429|GO:0032526|GO:0072073|GO:0030659|GO:0042476|GO:0010467|GO:0005788|GO:0007399|GO:0060562|GO:0071310|GO:0031328|GO:0009059|GO:0030154|GO:0001823|GO:0016070|GO:0010557|GO:0045165|GO:0030182|GO:0016055|GO:0045893|GO:0042481|GO:0030139|GO:0001657|GO:0043010|GO:0032774|GO:2001141|GO:0001838|GO:0072078|GO:0072163|GO:0001658|GO:0061333|GO:0072080|GO:0042475|GO:0005109|GO:0071300|GO:0022008|GO:0071396|GO:0006351|GO:0006355|GO:0048699|GO:1903506|GO:0060675|GO:0072079 developmental process|extracellular matrix|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|organic substance metabolic process|cell surface|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|extracellular space|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|regulation of metabolic process|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|tube development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|nephron morphogenesis|receptor binding|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cornea development in camera-type eye|positive regulation of biomineral tissue development|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|morphogenesis of a branching structure|cell-cell signaling|sensory organ development|vesicle membrane|organ morphogenesis|endocytic vesicle membrane|tissue morphogenesis|embryonic morphogenesis|nephron development|tooth mineralization|nucleobase-containing compound metabolic process|cell communication|tube formation|signal transduction|endoplasmic reticulum|extracellular exosome|positive regulation of odontogenesis|cellular developmental process|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|regulation of gene expression|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|eye development|morphogenesis of an epithelium|response to lipid|mesonephric tubule development|cytoplasmic vesicle|urogenital system development|axis specification|regulation of RNA metabolic process|branching morphogenesis of an epithelial tube|morphogenesis of a branching epithelium|biomineral tissue development|embryo development|positive regulation of gene expression|cytoplasmic, membrane-bounded vesicle|epithelial tube formation|positive regulation of tooth mineralization|regulation of organ morphogenesis|renal system development|Golgi lumen|morphogenesis of embryonic epithelium|membrane-bounded vesicle|G-protein coupled receptor binding|epithelial-mesenchymal cell signaling|renal tubule development|kidney morphogenesis|epithelium development|response to retinoic acid|kidney epithelium development|cytoplasmic vesicle membrane|odontogenesis|gene expression|endoplasmic reticulum lumen|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|mesonephros development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|cell fate commitment|neuron differentiation|Wnt signaling pathway|positive regulation of transcription, DNA-templated|regulation of odontogenesis|endocytic vesicle|ureteric bud development|camera-type eye development|RNA biosynthetic process|regulation of RNA biosynthetic process|embryonic epithelial tube formation|nephron tubule morphogenesis|mesonephric epithelium development|branching involved in ureteric bud morphogenesis|renal tubule morphogenesis|nephron tubule development|odontogenesis of dentin-containing tooth|frizzled binding|cellular response to retinoic acid|neurogenesis|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|generation of neurons|regulation of nucleic acid-templated transcription|ureteric bud morphogenesis|nephron tubule formation K00445 wingless-type MMTV integration site family, member 6[-] hsa05200|hsa05166|hsa05205|hsa04390|hsa04310|hsa04550|hsa04916|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Proteoglycans in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Wnt signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|Melanogenesis - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 2:218859821-218874233 9 5 20 18 43 52 0.301579913314986 0.152281826173954 0.604244926543946 0.540403234822823 1.18219539578277 1.63300893422253 0.352702222010962 1.11853585494271 -1.66508893325276 0.0019980885484448 0.0107661402795327 DOWN ENSG00000261773 WI2-89031B12.1 - - - - - - - X:154517840-154518631 9 16 7 1 4 4 0.803832319454463 1.29873337533474 0.563652764899149 0.0799858503798132 0.293101853080231 0.334776491806657 0.888739486562784 0.235954731755567 1.91325048524205 0.00200633857155458 0.0108059230949288 UP ENSG00000237378 RP11-473M10.3 - - - - - - - 13:63746741-63751080 0 0 0 3 3 4 0 0 0 0.0730632201054886 0.0669221988486257 0.10189968543846 0 0.0806283681308581 -Inf 0.00200854917312196 0.0108139273245055 DOWN ENSG00000105929 ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 [Source:HGNC Symbol;Acc:HGNC:866] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0042995|GO:0022857|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0045177|GO:0016043|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0005903|GO:0006725|GO:0006810|GO:1901360|GO:0016324|GO:0050877|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0016817|GO:0022607|GO:0043231|GO:0019899|GO:0033177|GO:0010243|GO:0005774|GO:0005737|GO:0012506|GO:0042592|GO:0030666|GO:0045184|GO:0019725|GO:0022891|GO:0006139|GO:0055086|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0070062|GO:0001503|GO:0009725|GO:0007588|GO:0016469|GO:0010008|GO:0031253|GO:0016021|GO:0044249|GO:0010033|GO:0005768|GO:0006996|GO:0016820|GO:0007166|GO:0031410|GO:0019693|GO:0048878|GO:0016471|GO:0031526|GO:0051117|GO:0015031|GO:1901652|GO:0005773|GO:0071417|GO:0016023|GO:0016818|GO:0009116|GO:0006811|GO:0033176|GO:0055082|GO:0015075|GO:0090382|GO:0007600|GO:0043434|GO:0031988|GO:0006461|GO:0006796|GO:0030659|GO:1901137|GO:0071310|GO:0033179|GO:0000220|GO:0090662|GO:0032870|GO:0030670|GO:0034220|GO:0033572|GO:0009142|GO:0098655|GO:0009124|GO:0034622|GO:0030139|GO:0050954|GO:0009259|GO:1901653|GO:0000323|GO:0009117|GO:0015992|GO:0046390|GO:0006812|GO:0043623|GO:0015991|GO:0007167|GO:0042625|GO:0071375|GO:0006163|GO:0050801|GO:0032868|GO:0042626|GO:0009165|GO:0016462|GO:0042278|GO:0005765|GO:0006873|GO:0008324|GO:0019829|GO:0006164|GO:0007605|GO:0005764|GO:1902600|GO:0017111|GO:0045335|GO:0032869|GO:0022890|GO:0030001|GO:0030003|GO:0015672|GO:0009156|GO:0007169|GO:0016887|GO:0046034|GO:0055065|GO:0009152|GO:0046961|GO:0006875|GO:0009168|GO:0015077|GO:0008286|GO:0042623|GO:0015078|GO:0006885|GO:0030641|GO:0006754|GO:0015986|GO:0006826|GO:0070072|GO:0006879|GO:0051453|GO:0055072|GO:0043492|GO:0045851|GO:0051452|GO:0007035 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|cell projection|transmembrane transporter activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|apical part of cell|cellular component organization|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|brush border|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|apical plasma membrane|neurological system process|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|proton-transporting two-sector ATPase complex, proton-transporting domain|response to organonitrogen compound|vacuolar membrane|cytoplasm|vesicle membrane|homeostatic process|endocytic vesicle membrane|establishment of protein localization|cellular homeostasis|substrate-specific transmembrane transporter activity|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|protein localization|cell communication|transmembrane transport|signal transduction|extracellular exosome|ossification|response to hormone|excretion|proton-transporting two-sector ATPase complex|endosome membrane|cell projection membrane|integral component of membrane|cellular biosynthetic process|response to organic substance|endosome|organelle organization|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|cell surface receptor signaling pathway|cytoplasmic vesicle|ribose phosphate metabolic process|chemical homeostasis|vacuolar proton-transporting V-type ATPase complex|brush border membrane|ATPase binding|protein transport|response to peptide|vacuole|cellular response to organonitrogen compound|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nucleoside metabolic process|ion transport|proton-transporting V-type ATPase complex|cellular chemical homeostasis|ion transmembrane transporter activity|phagosome maturation|sensory perception|response to peptide hormone|membrane-bounded vesicle|protein complex assembly|phosphate-containing compound metabolic process|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular response to organic substance|proton-transporting V-type ATPase, V0 domain|vacuolar proton-transporting V-type ATPase, V0 domain|ATP hydrolysis coupled transmembrane transport|cellular response to hormone stimulus|phagocytic vesicle membrane|ion transmembrane transport|transferrin transport|nucleoside triphosphate biosynthetic process|cation transmembrane transport|nucleoside monophosphate biosynthetic process|cellular macromolecular complex assembly|endocytic vesicle|sensory perception of mechanical stimulus|ribonucleotide metabolic process|cellular response to peptide|lytic vacuole|nucleotide metabolic process|proton transport|ribose phosphate biosynthetic process|cation transport|cellular protein complex assembly|ATP hydrolysis coupled proton transport|enzyme linked receptor protein signaling pathway|ATPase coupled ion transmembrane transporter activity|cellular response to peptide hormone stimulus|purine nucleotide metabolic process|ion homeostasis|response to insulin|ATPase activity, coupled to transmembrane movement of substances|nucleotide biosynthetic process|pyrophosphatase activity|purine nucleoside metabolic process|lysosomal membrane|cellular ion homeostasis|cation transmembrane transporter activity|cation-transporting ATPase activity|purine nucleotide biosynthetic process|sensory perception of sound|lysosome|hydrogen ion transmembrane transport|nucleoside-triphosphatase activity|phagocytic vesicle|cellular response to insulin stimulus|inorganic cation transmembrane transporter activity|metal ion transport|cellular cation homeostasis|monovalent inorganic cation transport|ribonucleoside monophosphate biosynthetic process|transmembrane receptor protein tyrosine kinase signaling pathway|ATPase activity|ATP metabolic process|metal ion homeostasis|purine ribonucleotide biosynthetic process|proton-transporting ATPase activity, rotational mechanism|cellular metal ion homeostasis|purine ribonucleoside monophosphate biosynthetic process|monovalent inorganic cation transmembrane transporter activity|insulin receptor signaling pathway|ATPase activity, coupled|hydrogen ion transmembrane transporter activity|regulation of pH|regulation of cellular pH|ATP biosynthetic process|ATP synthesis coupled proton transport|iron ion transport|vacuolar proton-transporting V-type ATPase complex assembly|cellular iron ion homeostasis|regulation of intracellular pH|iron ion homeostasis|ATPase activity, coupled to movement of substances|pH reduction|intracellular pH reduction|vacuolar acidification K02154 V-type H+-transporting ATPase subunit a[-] hsa01100|hsa05152|hsa04145|hsa00190|hsa04142|hsa05323|hsa05120|hsa04721|hsa05110|hsa04966 Metabolic pathways - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Phagosome - Homo sapiens (human)|Oxidative phosphorylation - Homo sapiens (human)|Lysosome - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)|Synaptic vesicle cycle - Homo sapiens (human)|Vibrio cholerae infection - Homo sapiens (human)|Collecting duct acid secretion - Homo sapiens (human) 7:138706295-138799560 14 5 14 31 46 23 0.192000027573325 0.0623239501848037 0.173108322596741 0.380905438831681 0.517593261322518 0.295615295451478 0.142477433451623 0.398037998535226 -1.48217273015323 0.00201829814637766 0.0108585822421983 DOWN ENSG00000236882 LINC01554 long intergenic non-protein coding RNA 1554 [Source:HGNC Symbol;Acc:HGNC:24687] - - - - - - 5:95852232-95860133 0 0 1 6 3 6 0 0 0.0267609898488012 0.159649502787997 0.0731030904299429 0.166996217051516 0.0089203299496004 0.133249603423152 -3.90089035476915 0.00203210312356852 0.0109171147473483 DOWN ENSG00000259319 RP11-293M10.6 - - - - - - - 14:75423683-75427741 13 6 18 34 61 22 0.197417228166723 0.0828088906127988 0.246458766840026 0.462620195453056 0.76005704756832 0.313116777278017 0.175561628539849 0.511931340099798 -1.54397277181451 0.0020409435129004 0.0109606633628582 DOWN ENSG00000078804 TP53INP2 tumor protein p53 inducible nuclear protein 2 [Source:HGNC Symbol;Acc:HGNC:16104] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0051641|GO:0006914|GO:0016043|GO:0043227|GO:1903828|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0060341|GO:0032182|GO:0010506|GO:0006725|GO:1901360|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0022607|GO:0043231|GO:0005737|GO:0010508|GO:0032880|GO:0042592|GO:0048871|GO:0006139|GO:0008104|GO:0001503|GO:0016236|GO:0048869|GO:0044249|GO:0019538|GO:0031323|GO:0006996|GO:0005829|GO:0010468|GO:0034645|GO:0030163|GO:0031410|GO:0043130|GO:0001894|GO:0051252|GO:0044265|GO:0005773|GO:0010628|GO:0001649|GO:0031981|GO:0006508|GO:0005654|GO:0034613|GO:0070925|GO:0044267|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:1903827|GO:0000045|GO:0016070|GO:0010557|GO:0005634|GO:0007033|GO:0044257|GO:0045893|GO:0032774|GO:2001141|GO:0016604|GO:0051603|GO:0005776|GO:0006351|GO:0006355|GO:0019941|GO:1903506|GO:0016605|GO:0006511 developmental process|cell|cellular process|metabolic process|binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular localization|autophagy|cellular component organization|membrane-bounded organelle|negative regulation of cellular protein localization|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|regulation of metabolic process|regulation of cellular localization|ubiquitin-like protein binding|regulation of autophagy|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|positive regulation of autophagy|regulation of protein localization|homeostatic process|multicellular organismal homeostasis|nucleobase-containing compound metabolic process|protein localization|ossification|macroautophagy|cellular developmental process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|organelle organization|cytosol|regulation of gene expression|cellular macromolecule biosynthetic process|protein catabolic process|cytoplasmic vesicle|ubiquitin binding|tissue homeostasis|regulation of RNA metabolic process|cellular macromolecule catabolic process|vacuole|positive regulation of gene expression|osteoblast differentiation|nuclear lumen|proteolysis|nucleoplasm|cellular protein localization|organelle assembly|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|regulation of cellular protein localization|autophagosome assembly|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|vacuole organization|cellular protein catabolic process|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear body|proteolysis involved in cellular protein catabolic process|autophagosome|transcription, DNA-templated|regulation of transcription, DNA-templated|modification-dependent protein catabolic process|regulation of nucleic acid-templated transcription|PML body|ubiquitin-dependent protein catabolic process - - - - 20:34704290-34713439 89 93 191 41 69 80 1.30776594862001 1.24195046074186 2.53039209883267 0.539783709921511 0.831869352482825 1.10168140443936 1.69336950273151 0.824444822281232 1.03840196516123 0.00204818354149132 0.0109896605765065 UP ENSG00000153714 LURAP1L leucine rich adaptor protein 1-like [Source:HGNC Symbol;Acc:HGNC:31452] - - - - - - 9:12775021-12822131 47 28 54 93 86 109 1.33412644901124 0.722329236843477 1.38200162900032 2.36524674104874 2.00292419034662 2.89970423913583 1.14615243828501 2.42262505684373 -1.07977220472955 0.00205558432551804 0.011019467490396 DOWN ENSG00000119865 CNRIP1 cannabinoid receptor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24546] GO:0005623|GO:0043209 cell|myelin sheath - - - - 2:68284171-68320051 7 11 6 1 3 1 0.0894450995505065 0.127743993411784 0.0691236112681144 0.0114430624098288 0.0314544005426525 0.0119735811737208 0.0954375680768016 0.0182903480420674 2.38347475300204 0.00205998472276054 0.0110371112550777 UP ENSG00000132837 DMGDH dimethylglycine dehydrogenase [Source:HGNC Symbol;Acc:HGNC:24475] GO:0009055|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0005622|GO:0006082|GO:0003676|GO:0034641|GO:0044281|GO:0043231|GO:0005737|GO:0006520|GO:0055114|GO:0003723|GO:0006066|GO:0009308|GO:0006577|GO:0005759|GO:0005739|GO:0019695|GO:0006576|GO:0019752|GO:0044822|GO:0009069|GO:0006579|GO:0047865|GO:0006544 electron carrier activity|cell|cellular process|metabolic process|binding|catalytic activity|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|organic acid metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|oxidation-reduction process|RNA binding|alcohol metabolic process|amine metabolic process|amino-acid betaine metabolic process|mitochondrial matrix|mitochondrion|choline metabolic process|cellular biogenic amine metabolic process|carboxylic acid metabolic process|poly(A) RNA binding|serine family amino acid metabolic process|amino-acid betaine catabolic process|dimethylglycine dehydrogenase activity|glycine metabolic process K00315 dimethylglycine dehydrogenase[1.5.8.4] hsa01100|hsa00260 Metabolic pathways - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human) 5:78997606-79236038 2 3 4 16 6 21 0.0208162339458991 0.0283832152582517 0.037538582693769 0.14920975919619 0.0512367571305643 0.204847216955986 0.0289126772993066 0.135097911094247 -2.22423125470698 0.00209595129513755 0.0111976610531561 DOWN ENSG00000166831 RBPMS2 RNA binding protein with multiple splicing 2 [Source:HGNC Symbol;Acc:HGNC:19098] GO:0005488|GO:0036094|GO:0097159|GO:0003676|GO:0000166 binding|small molecule binding|organic cyclic compound binding|nucleic acid binding|nucleotide binding - - - - 15:64739892-64775587 13 6 11 26 35 25 0.287006694382208 0.12038820614058 0.218952933142004 0.514306507355074 0.634001605873389 0.517276899093058 0.208782611221597 0.555195004107174 -1.41099302610665 0.00209895743333123 0.0112117150142549 DOWN ENSG00000270890 RP3-468K18.6 - - - - - - - 6:143858062-143858689 19 17 16 2 12 5 2.14008093390061 1.74030980892046 1.62491852220926 0.201849849066353 1.10902567558529 0.527865037641707 1.83510308834344 0.61291352076445 1.58210567400629 0.00210758287775981 0.0112497370342645 UP ENSG00000140839 CLEC18B C-type lectin domain family 18 member B [Source:HGNC Symbol;Acc:HGNC:33849] GO:0005623|GO:0005576|GO:0005488|GO:0043229|GO:0030246|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0043231|GO:0005737|GO:0005783|GO:0005794|GO:0005768|GO:0016528|GO:0016529 cell|extracellular region|binding|intracellular organelle|carbohydrate binding|membrane-bounded organelle|intracellular|protein binding|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|Golgi apparatus|endosome|sarcoplasm|sarcoplasmic reticulum - - - - 16:74408270-74421953 5 12 10 18 28 33 0.067525953649346 0.147279042563733 0.121760313090327 0.217791376233482 0.310246833939418 0.417661638882456 0.112188436434469 0.315233283018452 -1.49049588459878 0.00212373017007159 0.011325802161007 DOWN ENSG00000261614 CSDAP1 - - - - - - - 16:31568386-31569475 24 27 29 7 18 12 1.55749703826134 1.59246567045206 1.69681663644754 0.407003586368642 0.958415711676035 0.729816019525705 1.61559311505365 0.698411772523461 1.20991412048781 0.00214434939210847 0.0114214820253357 UP ENSG00000198553 KCNRG potassium channel regulator [Source:HGNC Symbol;Acc:HGNC:18893] GO:0005623|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0051051|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0042802|GO:0006810|GO:0022607|GO:0043231|GO:0005737|GO:0044092|GO:0055085|GO:0005783|GO:0071804|GO:0032410|GO:0034763|GO:0043271|GO:0043267|GO:0006811|GO:0032413|GO:0034766|GO:0034765|GO:0006461|GO:0043269|GO:0071805|GO:0022898|GO:0034220|GO:1901380|GO:0098655|GO:1901379|GO:0051259|GO:2001258|GO:1901017|GO:0006812|GO:0032412|GO:1901016|GO:0043266|GO:1903817|GO:0030001|GO:2001257|GO:0051260|GO:0015672|GO:1902259|GO:1902260|GO:0006813 cell|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|negative regulation of transport|cellular component organization|membrane-bounded organelle|intracellular|protein binding|endomembrane system|identical protein binding|transport|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|negative regulation of molecular function|transmembrane transport|endoplasmic reticulum|cellular potassium ion transport|negative regulation of transporter activity|negative regulation of transmembrane transport|negative regulation of ion transport|negative regulation of potassium ion transport|ion transport|negative regulation of ion transmembrane transporter activity|negative regulation of ion transmembrane transport|regulation of ion transmembrane transport|protein complex assembly|regulation of ion transport|potassium ion transmembrane transport|regulation of transmembrane transporter activity|ion transmembrane transport|negative regulation of potassium ion transmembrane transport|cation transmembrane transport|regulation of potassium ion transmembrane transport|protein oligomerization|negative regulation of cation channel activity|negative regulation of potassium ion transmembrane transporter activity|cation transport|regulation of ion transmembrane transporter activity|regulation of potassium ion transmembrane transporter activity|regulation of potassium ion transport|negative regulation of voltage-gated potassium channel activity|metal ion transport|regulation of cation channel activity|protein homooligomerization|monovalent inorganic cation transport|regulation of delayed rectifier potassium channel activity|negative regulation of delayed rectifier potassium channel activity|potassium ion transport - - - - 13:50015254-50020922 0 21 19 3 0 1 0 0.57892957475057 0.519618187718991 0.0815225123132425 0 0.0284244191156596 0.366182587489854 0.0366489771429674 3.32071835149472 0.00215410849647629 0.0114693273292136 UP ENSG00000262884 CTD-3060P21.1 - - - - - - - 17:2962248-2965895 3 4 3 11 12 17 0.0833597090804964 0.101001260139936 0.075137777617153 0.273824555997313 0.27355385870682 0.442654636654364 0.0864995822791951 0.330011017119499 -1.93174911747929 0.00217065970123489 0.0115471979188643 DOWN ENSG00000215866 LINC01356 long intergenic non-protein coding RNA 1356 [Source:HGNC Symbol;Acc:HGNC:50587] - - - - - - 1:112820170-112850643 33 29 44 14 19 20 0.873944952719129 0.698001566810515 1.05060559322413 0.332209635528149 0.412855242722288 0.496389345209721 0.874184037584591 0.413818074486719 1.0789403753535 0.00217921629882751 0.0115885862816524 UP ENSG00000226849 RP4-635E18.7 - - - - - - - 1:11068471-11073097 9 11 15 5 5 1 0.237373302389237 0.26368036820568 0.356688070758327 0.118147727042562 0.108202794639782 0.0247150430192834 0.285913913784415 0.0836885215672091 1.77247916302536 0.00218707920883828 0.0116262576033935 UP ENSG00000165985 C1QL3 complement component 1, q subcomponent-like 3 [Source:HGNC Symbol;Acc:HGNC:19359] GO:0032991|GO:0009987|GO:0005576|GO:0005488|GO:0050794|GO:0016043|GO:0005515|GO:0043234|GO:0051128|GO:0050803|GO:0050808|GO:0005581|GO:0050807 macromolecular complex|cellular process|extracellular region|binding|regulation of cellular process|cellular component organization|protein binding|protein complex|regulation of cellular component organization|regulation of synapse structure or activity|synapse organization|collagen trimer|regulation of synapse organization - - - - 10:16513743-16522005 5 12 14 22 34 29 0.107967321494284 0.235484623000255 0.272555777763733 0.425614969211941 0.60234368670146 0.586843152077238 0.205335907419424 0.538267269330213 -1.39033676548846 0.00218756848811528 0.0116267882578233 DOWN ENSG00000088002 SULT2B1 sulfotransferase family 2B member 1 [Source:HGNC Symbol;Acc:HGNC:11459] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0016740|GO:0006725|GO:1901360|GO:0006082|GO:0009410|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0055086|GO:0006629|GO:0005783|GO:0070062|GO:0006805|GO:0006790|GO:0005829|GO:0019693|GO:0050427|GO:0009116|GO:0000103|GO:0071466|GO:0008202|GO:0006796|GO:0008146|GO:0005634|GO:0009259|GO:0009117|GO:0050294|GO:0006163|GO:0004027|GO:0042278 cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|endomembrane system|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|response to xenobiotic stimulus|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|lipid metabolic process|endoplasmic reticulum|extracellular exosome|xenobiotic metabolic process|sulfur compound metabolic process|cytosol|ribose phosphate metabolic process|3'-phosphoadenosine 5'-phosphosulfate metabolic process|nucleoside metabolic process|sulfate assimilation|cellular response to xenobiotic stimulus|steroid metabolic process|phosphate-containing compound metabolic process|sulfotransferase activity|nucleus|ribonucleotide metabolic process|nucleotide metabolic process|steroid sulfotransferase activity|purine nucleotide metabolic process|alcohol sulfotransferase activity|purine nucleoside metabolic process K01015 alcohol sulfotransferase[2.8.2.2] hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) 19:48552075-48599425 75 72 152 197 187 242 1.48398577186952 1.2947372726414 2.71160752729664 3.49247865599109 3.03583656755533 4.48760709571173 1.83011019060252 3.67197410641938 -1.00462536983497 0.00219000106475651 0.0116317623773955 DOWN ENSG00000102043 MTMR8 myotubularin related protein 8 [Source:HGNC Symbol;Acc:HGNC:16825] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0043227|GO:0016787|GO:0005622|GO:0012505|GO:0019222|GO:0044255|GO:0010506|GO:0016788|GO:0019637|GO:0043231|GO:0005635|GO:0006629|GO:0019538|GO:0031323|GO:0046486|GO:0043412|GO:0036211|GO:0006796|GO:0044267|GO:0030258|GO:0005634|GO:0042578|GO:0006644|GO:0016311|GO:0046839|GO:0016791|GO:0006464|GO:0006650|GO:0006470|GO:0046488|GO:0004721|GO:0046856|GO:0052866|GO:0035335|GO:0034593|GO:0004725|GO:0004438|GO:0052629 cell|cellular process|metabolic process|catalytic activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|membrane-bounded organelle|hydrolase activity|intracellular|endomembrane system|regulation of metabolic process|cellular lipid metabolic process|regulation of autophagy|hydrolase activity, acting on ester bonds|organophosphate metabolic process|intracellular membrane-bounded organelle|nuclear envelope|lipid metabolic process|protein metabolic process|regulation of cellular metabolic process|glycerolipid metabolic process|macromolecule modification|protein modification process|phosphate-containing compound metabolic process|cellular protein metabolic process|lipid modification|nucleus|phosphoric ester hydrolase activity|phospholipid metabolic process|dephosphorylation|phospholipid dephosphorylation|phosphatase activity|cellular protein modification process|glycerophospholipid metabolic process|protein dephosphorylation|phosphatidylinositol metabolic process|phosphoprotein phosphatase activity|phosphatidylinositol dephosphorylation|phosphatidylinositol phosphate phosphatase activity|peptidyl-tyrosine dephosphorylation|phosphatidylinositol bisphosphate phosphatase activity|protein tyrosine phosphatase activity|phosphatidylinositol-3-phosphatase activity|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity K18083 myotubularin-related protein 6/7/8[3.1.3.95] hsa01100|hsa04070|hsa00562 Metabolic pathways - Homo sapiens (human)|Phosphatidylinositol signaling system - Homo sapiens (human)|Inositol phosphate metabolism - Homo sapiens (human) X:64268081-64395431 7 9 3 24 20 19 0.138315103662459 0.161624621052932 0.0534359725735395 0.424881660433516 0.324229457973924 0.351835250189231 0.11779189909631 0.366982122865557 -1.63946946136588 0.00218940862070694 0.0116317623773955 DOWN ENSG00000184117 NIPSNAP1 nipsnap homolog 1 (C. elegans) [Source:HGNC Symbol;Acc:HGNC:7827] GO:0045202|GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0042165|GO:0043227|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0097060|GO:0031090|GO:0019866|GO:0050877|GO:0043231|GO:0005737|GO:0031966|GO:0005740|GO:0007600|GO:0005743|GO:0005739|GO:0019233 synapse|cell|membrane|binding|intracellular organelle|neurotransmitter binding|membrane-bounded organelle|cell periphery|intracellular|protein binding|plasma membrane|synaptic membrane|organelle membrane|organelle inner membrane|neurological system process|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|mitochondrial envelope|sensory perception|mitochondrial inner membrane|mitochondrion|sensory perception of pain - - - - 22:29554808-29581337 933 2233 3831 4691 4571 5806 17.6605553558367 38.4141713982251 65.3806108460336 79.5583476260307 70.9907562508235 102.997950665522 40.4851125333651 84.5156848474587 -1.06182762119098 0.00219063693144279 0.0116317623773955 DOWN ENSG00000233895 RP1-122P22.2 - - - - - - - 20:19757708-19809675 0 1 2 7 7 6 0 0.0466408460746478 0.0924989876674598 0.321706968195664 0.294610753476191 0.288459020316686 0.0463799445807025 0.301592247329514 -2.70102634222634 0.00219123171469391 0.0116317623773955 DOWN ENSG00000280182 RP11-626G3.1 - - - - - - - 16:81261924-81264091 0 0 0 2 4 4 0 0 0 0.0584694212240173 0.107074108689826 0.122298423206122 0 0.0959473177066551 -Inf 0.00219014410572367 0.0116317623773955 DOWN ENSG00000260081 RP11-66N11.8 - - - - - - - X:153599340-153604353 21 24 22 4 14 10 1.13483897122598 1.1786823910601 1.07184904169134 0.193677166101863 0.620730678447162 0.506438480158581 1.12845680132581 0.440282108235869 1.3578510677831 0.00219461060413026 0.0116455572299511 UP ENSG00000163995 ABLIM2 actin binding LIM protein family member 2 [Source:HGNC Symbol;Acc:HGNC:19195] GO:0040011|GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0009605|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0006935|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0034641|GO:0046483|GO:0043169|GO:0006928|GO:0006139|GO:0008092|GO:0030030|GO:0048869|GO:0030029|GO:0044249|GO:0006996|GO:0000902|GO:0031175|GO:0034645|GO:0046872|GO:0007010|GO:0003779|GO:0000904|GO:0030036|GO:0010467|GO:0032990|GO:0007399|GO:0097485|GO:0009059|GO:0030154|GO:0048858|GO:0016070|GO:0005856|GO:0048666|GO:0030182|GO:0015629|GO:0007411|GO:0032774|GO:0061564|GO:0046914|GO:0022008|GO:0048667|GO:0048812|GO:0006351|GO:0007409|GO:0048699|GO:0008270 locomotion|developmental process|cell|cellular process|metabolic process|response to stimulus|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|response to external stimulus|biosynthetic process|intracellular|protein binding|anatomical structure development|chemotaxis|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|heterocycle metabolic process|cation binding|movement of cell or subcellular component|nucleobase-containing compound metabolic process|cytoskeletal protein binding|cell projection organization|cellular developmental process|actin filament-based process|cellular biosynthetic process|organelle organization|cell morphogenesis|neuron projection development|cellular macromolecule biosynthetic process|metal ion binding|cytoskeleton organization|actin binding|cell morphogenesis involved in differentiation|actin cytoskeleton organization|gene expression|cell part morphogenesis|nervous system development|neuron projection guidance|macromolecule biosynthetic process|cell differentiation|cell projection morphogenesis|RNA metabolic process|cytoskeleton|neuron development|neuron differentiation|actin cytoskeleton|axon guidance|RNA biosynthetic process|axon development|transition metal ion binding|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|transcription, DNA-templated|axonogenesis|generation of neurons|zinc ion binding K07520 actin-binding LIM protein[-] hsa04360 Axon guidance - Homo sapiens (human) 4:7965310-8158832 2 2 11 14 14 35 0.00860296314134822 0.00781893725116389 0.0426614690943189 0.0539608329175192 0.0494123362981838 0.141102113550337 0.0196944564956103 0.0814917609220133 -2.04886460192364 0.0021958606744018 0.0116459805602401 DOWN ENSG00000260337 RP11-386M24.6 - - - - - - - 15:92592574-92596462 99 119 119 182 184 428 1.67174048845509 1.82626387492651 1.81175013528875 2.75362388760364 2.54930586988664 6.7734293091272 1.76991816622345 4.02545302220583 -1.18546849491501 0.00219515659109016 0.0116459805602401 DOWN ENSG00000265474 AC010761.9 - - - - - - - 17:28745569-28747652 10 11 8 3 3 3 1.35764996061737 1.35737187625266 0.979317497070457 0.364895391006682 0.334225645689298 0.381683754574192 1.23144644464683 0.360268263756724 1.77321041207005 0.00219559923153112 0.0116459805602401 UP ENSG00000238228 OR7E7P olfactory receptor family 7 subfamily E member 7 pseudogene [Source:HGNC Symbol;Acc:HGNC:8457] - - - - - - 7:97946987-97947998 0 0 0 4 4 2 0 0 0 0.250517203979584 0.229384058932355 0.130999496793909 0 0.203633586568616 -Inf 0.00219851124147859 0.0116538271667439 DOWN ENSG00000156206 CFAP161 cilia and flagella associated protein 161 [Source:HGNC Symbol;Acc:HGNC:26782] - - - - - - 15:81007033-81149175 0 0 0 4 4 2 0 0 0 0.127015736687043 0.116300935691154 0.0664185825428037 0 0.103245084973667 -Inf 0.0021996305591266 0.0116576905223088 DOWN ENSG00000267724 RP11-49K24.8 - - - - - - - 18:47105946-47108062 1 3 0 6 9 8 0.0334278192832375 0.0911158861100984 0 0.179633970543698 0.246734323506584 0.250522664039748 0.0415145684644453 0.225630319363343 -2.44227133780928 0.00220167601213592 0.0116643896479691 DOWN ENSG00000227719 AC006042.6 - - - - - - - 7:8114025-8116561 1 3 7 9 18 15 0.13505094164621 0.368115135295951 0.851933186641461 1.08854124877002 1.99365100329557 1.89776185909652 0.451699754527874 1.6599847037207 -1.87773391274683 0.00221530124120472 0.0117220140473105 DOWN ENSG00000211891 IGHE immunoglobulin heavy constant epsilon [Source:HGNC Symbol;Acc:HGNC:5522] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0045321|GO:0006950|GO:0071704|GO:0006955|GO:0003823|GO:0009986|GO:0016043|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0005615|GO:0002684|GO:0042571|GO:0002682|GO:0072562|GO:0005515|GO:0005886|GO:0043234|GO:0002757|GO:0002250|GO:0045087|GO:0006959|GO:0009897|GO:0050867|GO:0006810|GO:0005102|GO:0006952|GO:0098542|GO:0002696|GO:0001775|GO:0006956|GO:0008037|GO:0009617|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0061024|GO:0007165|GO:0050778|GO:0019538|GO:0002443|GO:0016192|GO:0051249|GO:0006909|GO:0042113|GO:0006910|GO:0007166|GO:0006958|GO:0051251|GO:0002429|GO:0010324|GO:0002764|GO:0002460|GO:0034987|GO:0042742|GO:0002455|GO:0002768|GO:0050871|GO:0050864|GO:0006911|GO:0019724|GO:0006897|GO:0050851|GO:0016064|GO:0038093|GO:0050853|GO:0038095 macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|leukocyte activation|response to stress|organic substance metabolic process|immune response|antigen binding|cell surface|cellular component organization|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|extracellular space|positive regulation of immune system process|immunoglobulin complex, circulating|regulation of immune system process|blood microparticle|protein binding|plasma membrane|protein complex|immune response-activating signal transduction|adaptive immune response|innate immune response|humoral immune response|external side of plasma membrane|positive regulation of cell activation|transport|receptor binding|defense response|defense response to other organism|positive regulation of leukocyte activation|cell activation|complement activation|cell recognition|response to bacterium|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|membrane organization|signal transduction|positive regulation of immune response|protein metabolic process|leukocyte mediated immunity|vesicle-mediated transport|regulation of lymphocyte activation|phagocytosis|B cell activation|phagocytosis, recognition|cell surface receptor signaling pathway|complement activation, classical pathway|positive regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|membrane invagination|immune response-regulating signaling pathway|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|immunoglobulin receptor binding|defense response to bacterium|humoral immune response mediated by circulating immunoglobulin|immune response-regulating cell surface receptor signaling pathway|positive regulation of B cell activation|regulation of B cell activation|phagocytosis, engulfment|B cell mediated immunity|endocytosis|antigen receptor-mediated signaling pathway|immunoglobulin mediated immune response|Fc receptor signaling pathway|B cell receptor signaling pathway|Fc-epsilon receptor signaling pathway - - - - 14:105599941-105601728 0 2 3 11 5 11 0 0.091058501528427 0.135482140094385 0.493737478448413 0.205524005116073 0.516440308714802 0.075513547207604 0.405233930759763 -2.42394758417804 0.00222068442163966 0.0117484162189669 DOWN ENSG00000173991 TCAP titin-cap [Source:HGNC Symbol;Acc:HGNC:11610] GO:0032502|GO:0005198|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0060090|GO:0051606|GO:0043229|GO:0006950|GO:0009628|GO:0009653|GO:0016043|GO:0009605|GO:0008307|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0030017|GO:0007507|GO:0030018|GO:0001756|GO:0009888|GO:0048468|GO:0044325|GO:0009612|GO:0048839|GO:0007275|GO:0048513|GO:0022607|GO:0009582|GO:0061061|GO:0005737|GO:0007389|GO:0003012|GO:0007423|GO:0006928|GO:0009887|GO:0048729|GO:0048598|GO:0048568|GO:0030674|GO:0031674|GO:0019904|GO:0019955|GO:0008092|GO:0030916|GO:0048869|GO:0030029|GO:0003013|GO:0006996|GO:0005829|GO:0036122|GO:0006936|GO:0051373|GO:0002009|GO:0007010|GO:0072358|GO:0043583|GO:0042692|GO:0035051|GO:0030048|GO:0048738|GO:0003007|GO:0055006|GO:0009790|GO:0060537|GO:0042472|GO:0003002|GO:0043292|GO:0035994|GO:0006461|GO:0055001|GO:0030036|GO:0070925|GO:0050982|GO:0060429|GO:0070080|GO:0014896|GO:0048562|GO:0031432|GO:0007512|GO:0060415|GO:0071599|GO:0030154|GO:0030239|GO:0007517|GO:0072359|GO:0008015|GO:0050881|GO:0014898|GO:0048644|GO:0006941|GO:0055002|GO:0014866|GO:0071600|GO:0055003|GO:0070252|GO:0030016|GO:0009792|GO:0048739|GO:0034622|GO:0055013|GO:0003009|GO:0060047|GO:0043623|GO:0061053|GO:0042471|GO:0035995|GO:0051146|GO:0030049|GO:0009952|GO:0030241|GO:0031032|GO:0055008|GO:0014706|GO:0055007|GO:0007015|GO:0045214|GO:0048769|GO:0035282|GO:0003300|GO:0030240|GO:0033275|GO:0060048|GO:0048747|GO:0043009 developmental process|structural molecule activity|cell|cellular process|response to stimulus|binding|binding, bridging|detection of stimulus|intracellular organelle|response to stress|response to abiotic stimulus|anatomical structure morphogenesis|cellular component organization|response to external stimulus|structural constituent of muscle|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|sarcomere|heart development|Z disc|somitogenesis|tissue development|cell development|ion channel binding|response to mechanical stimulus|inner ear development|multicellular organism development|animal organ development|cellular component assembly|detection of abiotic stimulus|muscle structure development|cytoplasm|pattern specification process|muscle system process|sensory organ development|movement of cell or subcellular component|organ morphogenesis|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|protein binding, bridging|I band|protein domain specific binding|cytokine binding|cytoskeletal protein binding|otic vesicle formation|cellular developmental process|actin filament-based process|circulatory system process|organelle organization|cytosol|BMP binding|muscle contraction|FATZ binding|morphogenesis of an epithelium|cytoskeleton organization|cardiovascular system development|ear development|muscle cell differentiation|cardiocyte differentiation|actin filament-based movement|cardiac muscle tissue development|heart morphogenesis|cardiac cell development|embryo development|muscle tissue development|inner ear morphogenesis|regionalization|contractile fiber|response to muscle stretch|protein complex assembly|muscle cell development|actin cytoskeleton organization|organelle assembly|detection of mechanical stimulus|epithelium development|titin Z domain binding|muscle hypertrophy|embryonic organ morphogenesis|titin binding|adult heart development|muscle tissue morphogenesis|otic vesicle development|cell differentiation|myofibril assembly|muscle organ development|circulatory system development|blood circulation|musculoskeletal movement|cardiac muscle hypertrophy in response to stress|muscle organ morphogenesis|striated muscle contraction|striated muscle cell development|skeletal myofibril assembly|otic vesicle morphogenesis|cardiac myofibril assembly|actin-mediated cell contraction|myofibril|embryo development ending in birth or egg hatching|cardiac muscle fiber development|cellular macromolecular complex assembly|cardiac muscle cell development|skeletal muscle contraction|heart contraction|cellular protein complex assembly|somite development|ear morphogenesis|detection of muscle stretch|striated muscle cell differentiation|muscle filament sliding|anterior/posterior pattern specification|skeletal muscle myosin thick filament assembly|actomyosin structure organization|cardiac muscle tissue morphogenesis|striated muscle tissue development|cardiac muscle cell differentiation|actin filament organization|sarcomere organization|sarcomerogenesis|segmentation|cardiac muscle hypertrophy|skeletal muscle thin filament assembly|actin-myosin filament sliding|cardiac muscle contraction|muscle fiber development|chordate embryonic development - - - - 17:39664187-39666555 28 24 32 9 14 16 0.731931272541581 0.570175628195738 0.754187330207352 0.210789214469878 0.300272157460212 0.391985572632777 0.68543141031489 0.301015648187622 1.18717381885245 0.00223113086958264 0.0117974107298123 UP ENSG00000225968 ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 [Source:HGNC Symbol;Acc:HGNC:33154] GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0042995|GO:0009892|GO:0048523|GO:0050794|GO:0060076|GO:0071704|GO:0044237|GO:0016043|GO:0043227|GO:0031224|GO:0030234|GO:0005515|GO:0019222|GO:0004857|GO:0019208|GO:0031982|GO:0019899|GO:0043005|GO:0036477|GO:0044092|GO:0070062|GO:0050808|GO:0050790|GO:0043086|GO:0016021|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0043412|GO:0036211|GO:0032269|GO:0019902|GO:0030425|GO:0051346|GO:0019212|GO:0006796|GO:0044267|GO:0051174|GO:0019888|GO:0051246|GO:0010923|GO:0016311|GO:0004864|GO:0006464|GO:0010921|GO:0006470|GO:0035304|GO:0035305|GO:0035303|GO:0035308 synapse|cell|membrane|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|cell projection|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|excitatory synapse|organic substance metabolic process|cellular metabolic process|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|enzyme regulator activity|protein binding|regulation of metabolic process|enzyme inhibitor activity|phosphatase regulator activity|vesicle|enzyme binding|neuron projection|somatodendritic compartment|negative regulation of molecular function|extracellular exosome|synapse organization|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|macromolecule modification|protein modification process|negative regulation of cellular protein metabolic process|phosphatase binding|dendrite|negative regulation of hydrolase activity|phosphatase inhibitor activity|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|protein phosphatase regulator activity|regulation of protein metabolic process|negative regulation of phosphatase activity|dephosphorylation|protein phosphatase inhibitor activity|cellular protein modification process|regulation of phosphatase activity|protein dephosphorylation|regulation of protein dephosphorylation|negative regulation of dephosphorylation|regulation of dephosphorylation|negative regulation of protein dephosphorylation - - - - 7:1688119-1747954 23 15 18 7 7 8 0.413356539438807 0.245005070082295 0.291667920716678 0.112711867160015 0.103218554126948 0.134745040592517 0.31667651007926 0.116891820626493 1.4378358749823 0.00223089533269764 0.0117974107298123 UP ENSG00000250506 CDK3 cyclin-dependent kinase 3 [Source:HGNC Symbol;Acc:HGNC:1772] GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0008283|GO:0050794|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0016043|GO:0016740|GO:0051726|GO:0007049|GO:0022402|GO:0043168|GO:0001882|GO:0016772|GO:0033554|GO:0000166|GO:0051301|GO:0019538|GO:0006996|GO:0035639|GO:1903047|GO:0043412|GO:0001883|GO:0044770|GO:0036211|GO:0000278|GO:0032549|GO:0016301|GO:0045023|GO:0006796|GO:0044267|GO:0007067|GO:0017076|GO:0016773|GO:0006974|GO:0005524|GO:0044772|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468|GO:0000082|GO:0004674|GO:0097472|GO:0004693 cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|cell proliferation|regulation of cellular process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|cellular component organization|transferase activity|regulation of cell cycle|cell cycle|cell cycle process|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|cellular response to stress|nucleotide binding|cell division|protein metabolic process|organelle organization|purine ribonucleoside triphosphate binding|mitotic cell cycle process|macromolecule modification|purine nucleoside binding|cell cycle phase transition|protein modification process|mitotic cell cycle|ribonucleoside binding|kinase activity|G0 to G1 transition|phosphate-containing compound metabolic process|cellular protein metabolic process|mitotic nuclear division|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|cellular response to DNA damage stimulus|ATP binding|mitotic cell cycle phase transition|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation|G1/S transition of mitotic cell cycle|protein serine/threonine kinase activity|cyclin-dependent protein kinase activity|cyclin-dependent protein serine/threonine kinase activity - - - - 17:76000906-76005999 10 6 15 31 21 39 0.322836891593633 0.176049206971436 0.436621362744789 0.896718509125426 0.556277812474214 1.18005324211913 0.311835820436619 0.877683187906257 -1.49291361338808 0.00225793058814597 0.0119262328027633 DOWN ENSG00000281903 AF127936.7 - - - - - - - 21:14819699-14918552 6 11 19 30 35 30 0.108653706525599 0.181052418721873 0.310227755699101 0.486779687658217 0.520056616799369 0.509179321129839 0.199977960315524 0.505338541862475 -1.33740920910125 0.00225829014651374 0.0119262328027633 DOWN ENSG00000236991 EDRF1-AS1 EDRF1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49501] - - - - - - 10:125725634-125752110 20 17 22 11 7 6 0.290858865113528 0.22469460526358 0.288456084616357 0.143330041029844 0.0835255405106224 0.0817814533340276 0.268003184997822 0.102879011624831 1.38130145838865 0.0022591697178678 0.0119287677320879 UP ENSG00000248996 RP11-1334A24.6 - - - - - - - 5:177494995-177503647 9 7 7 1 2 2 1.46690137559432 1.03696207191557 1.02860135898646 0.145964961983438 0.267438557188414 0.305464264413447 1.17748826883212 0.239622594528433 2.29687683205672 0.00226721952355111 0.0119670388359432 UP ENSG00000213453 FTH1P3 ferritin, heavy polypeptide 1 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:3990] - - - - - - 2:27392784-27393367 11 9 9 4 3 2 1.33236699127443 0.990781067413519 0.982823790742385 0.434115428813936 0.298170481856377 0.227005977320952 1.10199061647678 0.319763962663755 1.78503267767498 0.00226881241402362 0.0119720934603135 UP ENSG00000279406 RP11-327E2.5 - - - - - - - 10:71364243-71366374 17 19 12 41 40 40 0.564026125981827 0.572931127654873 0.358975902420526 1.21881743881902 1.08890292703669 1.24380037470016 0.498644385352409 1.18384024685196 -1.24739119894945 0.0022801504036774 0.0120267862458278 DOWN ENSG00000259516 ANP32AP1 acidic nuclear phosphoprotein 32 family member A pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:42949] - - - - - - 15:35181799-35238197 3 6 3 19 18 9 0.117191507078379 0.212989405010722 0.105632679079664 0.664938785435581 0.576848771798386 0.329454569381482 0.145271197056255 0.523747375538483 -1.85012242164126 0.00228088473066221 0.0120280206385551 DOWN ENSG00000233937 CTC-338M12.4 - - - - - - - 5:181246523-181272167 37 54 101 136 135 144 0.594962768925995 0.789159880034042 1.46429106178307 1.95941699556019 1.78112404765843 2.17011732647152 0.949471236914369 1.97021945656338 -1.05316013446234 0.00228830173971252 0.0120612570864014 DOWN ENSG00000109063 MYH3 myosin, heavy chain 3, skeletal muscle, embryonic [Source:HGNC Symbol;Acc:HGNC:7573] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0097159|GO:0044877|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0030017|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0048513|GO:0060325|GO:0034641|GO:0043168|GO:0005859|GO:0044281|GO:0001882|GO:0031982|GO:0019637|GO:0046483|GO:0016817|GO:0022607|GO:0061061|GO:0005737|GO:0003012|GO:0060322|GO:0006928|GO:0032403|GO:0048598|GO:0016459|GO:0006139|GO:0010171|GO:0055086|GO:0005516|GO:0070062|GO:0060323|GO:0008092|GO:0000166|GO:0060324|GO:0048869|GO:0030029|GO:0006996|GO:0005829|GO:0006936|GO:0035639|GO:0007010|GO:0019693|GO:0042692|GO:0030048|GO:0001883|GO:0003779|GO:0009790|GO:0016818|GO:0009116|GO:0032549|GO:0032982|GO:0043292|GO:0055001|GO:0030036|GO:0051015|GO:0070925|GO:0006796|GO:0035108|GO:0017076|GO:0030154|GO:0030239|GO:0060173|GO:0007517|GO:0005856|GO:0050881|GO:0016460|GO:0006941|GO:0055002|GO:0015629|GO:0070252|GO:0030016|GO:0009259|GO:0009117|GO:0003009|GO:0005524|GO:0030554|GO:0006163|GO:0051146|GO:0030049|GO:0031032|GO:0045214|GO:0030326|GO:0016462|GO:0042278|GO:0033275|GO:0017111|GO:0016887|GO:0046034|GO:0003774|GO:0000146|GO:0042623 developmental process|macromolecular complex|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|small molecule binding|extracellular vesicle|organic cyclic compound binding|macromolecular complex binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|sarcomere|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|animal organ development|face morphogenesis|cellular nitrogen compound metabolic process|anion binding|muscle myosin complex|small molecule metabolic process|nucleoside binding|vesicle|organophosphate metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|cellular component assembly|muscle structure development|cytoplasm|muscle system process|head development|movement of cell or subcellular component|protein complex binding|embryonic morphogenesis|myosin complex|nucleobase-containing compound metabolic process|body morphogenesis|nucleobase-containing small molecule metabolic process|calmodulin binding|extracellular exosome|head morphogenesis|cytoskeletal protein binding|nucleotide binding|face development|cellular developmental process|actin filament-based process|organelle organization|cytosol|muscle contraction|purine ribonucleoside triphosphate binding|cytoskeleton organization|ribose phosphate metabolic process|muscle cell differentiation|actin filament-based movement|purine nucleoside binding|actin binding|embryo development|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|nucleoside metabolic process|ribonucleoside binding|myosin filament|contractile fiber|muscle cell development|actin cytoskeleton organization|actin filament binding|organelle assembly|phosphate-containing compound metabolic process|limb morphogenesis|purine nucleotide binding|cell differentiation|myofibril assembly|limb development|muscle organ development|cytoskeleton|musculoskeletal movement|myosin II complex|striated muscle contraction|striated muscle cell development|actin cytoskeleton|actin-mediated cell contraction|myofibril|ribonucleotide metabolic process|nucleotide metabolic process|skeletal muscle contraction|ATP binding|adenyl nucleotide binding|purine nucleotide metabolic process|striated muscle cell differentiation|muscle filament sliding|actomyosin structure organization|sarcomere organization|embryonic limb morphogenesis|pyrophosphatase activity|purine nucleoside metabolic process|actin-myosin filament sliding|nucleoside-triphosphatase activity|ATPase activity|ATP metabolic process|motor activity|microfilament motor activity|ATPase activity, coupled K10352 myosin heavy chain[-] hsa04530 Tight junction - Homo sapiens (human) 17:10628526-10657309 60 65 40 32 25 28 0.55639912948828 0.547811360749526 0.334433053423545 0.265878757892851 0.190212553063784 0.243341953438295 0.479547847887117 0.233144421464977 1.04045086015397 0.00229038643057942 0.0120637255643116 UP ENSG00000081041 CXCL2 chemokine (C-X-C motif) ligand 2 [Source:HGNC Symbol;Acc:HGNC:4603] GO:0040011|GO:0002376|GO:0007610|GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0040012|GO:0006950|GO:0048520|GO:0050900|GO:0006955|GO:0050795|GO:0048870|GO:0040017|GO:0051707|GO:0009607|GO:0009605|GO:0005615|GO:0002684|GO:0002682|GO:0005515|GO:0051272|GO:0042127|GO:0006935|GO:0002685|GO:0005102|GO:0006952|GO:2000147|GO:0050920|GO:0006928|GO:0002687|GO:0009617|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0030595|GO:2000145|GO:0010033|GO:0050921|GO:0007186|GO:0005126|GO:0002688|GO:0007166|GO:0033993|GO:0034097|GO:0002237|GO:0002690|GO:0005125|GO:0030334|GO:0006954|GO:0060326|GO:1902622|GO:0001664|GO:0071310|GO:0030335|GO:0032496|GO:0071621|GO:0090023|GO:0019221|GO:1990266|GO:0042379|GO:0071622|GO:0030593|GO:0071624|GO:0008009|GO:0071345|GO:0090022|GO:0045236|GO:0070098 locomotion|immune system process|behavior|signaling|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|regulation of locomotion|response to stress|positive regulation of behavior|leukocyte migration|immune response|regulation of behavior|cell motility|positive regulation of locomotion|response to other organism|response to biotic stimulus|response to external stimulus|extracellular space|positive regulation of immune system process|regulation of immune system process|protein binding|positive regulation of cellular component movement|regulation of cell proliferation|chemotaxis|regulation of leukocyte migration|receptor binding|defense response|positive regulation of cell motility|regulation of chemotaxis|movement of cell or subcellular component|positive regulation of leukocyte migration|response to bacterium|cell communication|regulation of cellular component movement|cell migration|signal transduction|leukocyte chemotaxis|regulation of cell motility|response to organic substance|positive regulation of chemotaxis|G-protein coupled receptor signaling pathway|cytokine receptor binding|regulation of leukocyte chemotaxis|cell surface receptor signaling pathway|response to lipid|response to cytokine|response to molecule of bacterial origin|positive regulation of leukocyte chemotaxis|cytokine activity|regulation of cell migration|inflammatory response|cell chemotaxis|regulation of neutrophil migration|G-protein coupled receptor binding|cellular response to organic substance|positive regulation of cell migration|response to lipopolysaccharide|granulocyte chemotaxis|positive regulation of neutrophil chemotaxis|cytokine-mediated signaling pathway|neutrophil migration|chemokine receptor binding|regulation of granulocyte chemotaxis|neutrophil chemotaxis|positive regulation of granulocyte chemotaxis|chemokine activity|cellular response to cytokine stimulus|regulation of neutrophil chemotaxis|CXCR chemokine receptor binding|chemokine-mediated signaling pathway K05505 C-X-C motif chemokine 1/2/3[-] hsa04060|hsa04062|hsa04668|hsa04064|hsa05132|hsa04621|hsa05134 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Salmonella infection - Homo sapiens (human)|NOD-like receptor signaling pathway - Homo sapiens (human)|Legionellosis - Homo sapiens (human) 4:74097035-74099293 29 28 37 15 17 15 0.900119665168992 0.789839604306251 1.0354342034671 0.41714819218802 0.432939016889626 0.436343665715917 0.908464490980781 0.428810291597854 1.0830905937508 0.00229194851203684 0.012069823756985 UP ENSG00000267047 RP11-589P10.7 - - - - - - - 17:6985494-7019414 32 0 0 0 0 0 4.54539465108248 0 0 0 0 0 1.51513155036083 0 Inf 0.00229654127809851 0.0120897448979638 UP ENSG00000261140 RP11-20I23.6 - - - - - - - 16:2569043-2571936 1 5 5 11 12 18 0.154175802663647 0.700363692926399 0.694677311125705 1.51886126267791 1.51735974785961 2.59974825773362 0.516405602238584 1.87865642275705 -1.86312468728747 0.00230087877258834 0.0121061746346233 DOWN ENSG00000261512 RP11-46D6.1 - - - - - - - 16:46622861-46624451 36 27 59 78 87 107 0.943862412168917 0.643360852777148 1.39466454606208 1.83228841686322 1.87149451022209 2.6291665949485 0.993962603669382 2.11098317401127 -1.08665160074307 0.00231489294726348 0.0121713304064114 DOWN ENSG00000269693 CTD-2192J16.20 - GO:0005488|GO:0097159|GO:0043167|GO:0003676|GO:0043169|GO:0046872 binding|organic cyclic compound binding|ion binding|nucleic acid binding|cation binding|metal ion binding - - - - 19:12525720-12580975 0 0 0 39 0 0 0 0 0 0.422017598488729 0 0 0 0.140672532829576 -Inf 0.00232371899877697 0.012209135337819 DOWN ENSG00000170049 KCNAB3 potassium channel, voltage gated subfamily A regulatory beta subunit 3 [Source:HGNC Symbol;Acc:HGNC:6230] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0050794|GO:0071944|GO:0031224|GO:0016247|GO:0005622|GO:0005886|GO:0006810|GO:0005737|GO:0007267|GO:0015459|GO:0022891|GO:0007154|GO:0055085|GO:0071804|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0034765|GO:0043269|GO:0071805|GO:0034220|GO:0098655|GO:0005216|GO:0006812|GO:0008324|GO:0005244|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0007268|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249 transporter activity|signaling|cell|membrane|cellular process|transmembrane transporter activity|regulation of cellular process|cell periphery|intrinsic component of membrane|channel regulator activity|intracellular|plasma membrane|transport|cytoplasm|cell-cell signaling|potassium channel regulator activity|substrate-specific transmembrane transporter activity|cell communication|transmembrane transport|cellular potassium ion transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|regulation of ion transmembrane transport|regulation of ion transport|potassium ion transmembrane transport|ion transmembrane transport|cation transmembrane transport|ion channel activity|cation transport|cation transmembrane transporter activity|voltage-gated ion channel activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|synaptic transmission|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity - - - - 17:7921859-7929803 10 11 8 36 17 35 0.107350983378608 0.107328994919963 0.0774357893418892 0.346281161881014 0.149744729016764 0.352144962091629 0.0973719225468201 0.282723617663136 -1.53781467306794 0.00232514268348041 0.012214465893476 DOWN ENSG00000231439 WASIR2 WASH and IL9R antisense RNA 2 [Source:HGNC Symbol;Acc:HGNC:38609] - - - - - - 16:22910-25123 27 27 39 14 15 17 1.81205464044004 1.64685728727964 2.3598772805455 0.841870907491163 0.82599590670938 1.06925873332259 1.93959640275506 0.912375182507711 1.08805737358728 0.00233176534674131 0.012239425044298 UP ENSG00000144671 SLC22A14 solute carrier family 22 member 14 [Source:HGNC Symbol;Acc:HGNC:8495] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0006811|GO:0015075|GO:0006812|GO:0015695|GO:0008324|GO:0015101 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|plasma membrane|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|ion transport|ion transmembrane transporter activity|cation transport|organic cation transport|cation transmembrane transporter activity|organic cation transmembrane transporter activity - - - - 3:38282294-38318575 12 15 4 3 2 3 0.154115652927901 0.175079875788655 0.0463166681167128 0.0345153410883227 0.0210726822475983 0.0361033471556199 0.125170732277756 0.030563790163847 2.03400190152324 0.00233363246639208 0.0122461352876901 UP ENSG00000179715 PCED1B PC-esterase domain containing 1B [Source:HGNC Symbol;Acc:HGNC:28255] GO:0005488|GO:0005515 binding|protein binding - - - - 12:47079603-47236662 19 14 51 42 78 149 0.200263869242972 0.134111492938008 0.484664063373831 0.396652017773061 0.674557536241359 1.4718887442687 0.273013141851604 0.84769943276104 -1.63458242284325 0.00233861684670754 0.0122658234964172 DOWN ENSG00000261616 RP11-6O2.3 - - - - - - - 15:99139317-99145370 2 4 4 9 15 16 0.0528453963004595 0.0960587255570706 0.0952977990238529 0.213072698675939 0.325214675260249 0.396231960980311 0.0814006402937943 0.311506444972166 -1.93614996464958 0.00233844990872495 0.0122658234964172 DOWN ENSG00000164749 HNF4G hepatocyte nuclear factor 4, gamma [Source:HGNC Symbol;Acc:HGNC:5026] GO:0032502|GO:0004871|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0004872|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0038023|GO:0043227|GO:0004879|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0098531|GO:0006725|GO:0003707|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0000981|GO:0031018|GO:0006139|GO:0007154|GO:0007165|GO:0009725|GO:0031016|GO:0044249|GO:0010033|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0033993|GO:0051252|GO:0035270|GO:0031981|GO:0005654|GO:0014070|GO:0010467|GO:0071310|GO:0009059|GO:0009755|GO:0016070|GO:0032870|GO:0005634|GO:0048545|GO:0030522|GO:0043401|GO:0032774|GO:0043565|GO:2001141|GO:0071383|GO:0071407|GO:0046914|GO:0071396|GO:0006351|GO:0006355|GO:0006366|GO:0006352|GO:0006357|GO:1903506|GO:0008270|GO:0006367 developmental process|signal transducer activity|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|receptor activity|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|signaling receptor activity|membrane-bounded organelle|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|cellular aromatic compound metabolic process|steroid hormone receptor activity|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|RNA polymerase II transcription factor activity, sequence-specific DNA binding|endocrine pancreas development|nucleobase-containing compound metabolic process|cell communication|signal transduction|response to hormone|pancreas development|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|response to lipid|regulation of RNA metabolic process|endocrine system development|nuclear lumen|nucleoplasm|response to organic cyclic compound|gene expression|cellular response to organic substance|macromolecule biosynthetic process|hormone-mediated signaling pathway|RNA metabolic process|cellular response to hormone stimulus|nucleus|response to steroid hormone|intracellular receptor signaling pathway|steroid hormone mediated signaling pathway|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|transition metal ion binding|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|zinc ion binding|transcription initiation from RNA polymerase II promoter K08037 hepatocyte nuclear factor 4-gamma[-] hsa04950 Maturity onset diabetes of the young - Homo sapiens (human) 8:75407914-75566843 1 2 1 5 11 7 0.0134870770769228 0.0245044033082026 0.0121487855574318 0.060391119483162 0.121670458677951 0.0884449655792698 0.0167134219808524 0.0901688479134609 -2.43162194094646 0.00234319062635376 0.0122876537781776 DOWN ENSG00000121075 TBX4 T-box 4 [Source:HGNC Symbol;Acc:HGNC:11603] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0001568|GO:0007275|GO:0030324|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0009887|GO:0048729|GO:0048598|GO:0030323|GO:0006139|GO:0001525|GO:0044249|GO:0031323|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0002009|GO:0001944|GO:0072358|GO:0051252|GO:0060541|GO:0009790|GO:0060429|GO:0035108|GO:0010467|GO:0009059|GO:0001501|GO:0060173|GO:0016070|GO:0072359|GO:0005634|GO:0032774|GO:2001141|GO:0030326|GO:0006351|GO:0006355|GO:1903506 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|lung development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|organ morphogenesis|tissue morphogenesis|embryonic morphogenesis|respiratory tube development|nucleobase-containing compound metabolic process|angiogenesis|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|morphogenesis of an epithelium|vasculature development|cardiovascular system development|regulation of RNA metabolic process|respiratory system development|embryo development|epithelium development|limb morphogenesis|gene expression|macromolecule biosynthetic process|skeletal system development|limb development|RNA metabolic process|circulatory system development|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|embryonic limb morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 17:61452404-61485110 0 0 0 4 2 4 0 0 0 0.0377829225674126 0.0172978142801448 0.0395146023116054 0 0.0315317797197209 -Inf 0.00234406154918391 0.0122900620810215 DOWN ENSG00000280543 ASAP1-IT2 ASAP1 intronic transcript 2 [Source:HGNC Symbol;Acc:HGNC:48917] - - - - - - 8:130082738-130084768 0 1 0 4 8 3 0 0.0316680092254748 0 0.124826888442806 0.2286220859813 0.0979109976037195 0.0105560030751583 0.150453324009275 -3.83318039973352 0.00235415829900862 0.0123386660566368 DOWN ENSG00000247809 NR2F2-AS1 NR2F2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44222] - - - - - - 15:96110040-96327361 6 10 7 21 26 19 0.0517247261046911 0.0783513736490792 0.0544074332480348 0.162213997030775 0.183912807112114 0.153512516231255 0.0614945110006017 0.166546440124715 -1.43739497084327 0.00235546501800441 0.0123411815808185 DOWN ENSG00000131781 FMO5 flavin containing monooxygenase 5 [Source:HGNC Symbol;Acc:HGNC:3773] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0016491|GO:0043229|GO:0042175|GO:0043167|GO:0044237|GO:0043227|GO:0048037|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0043168|GO:0043231|GO:0005737|GO:0016705|GO:0004497|GO:0005783|GO:0050662|GO:0017144|GO:0000166|GO:0016021|GO:0055114|GO:0050660|GO:0016709|GO:0050661|GO:0004499 cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|ion binding|cellular metabolic process|membrane-bounded organelle|cofactor binding|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|anion binding|intracellular membrane-bounded organelle|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|endoplasmic reticulum|coenzyme binding|drug metabolic process|nucleotide binding|integral component of membrane|oxidation-reduction process|flavin adenine dinucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|NADP binding|N,N-dimethylaniline monooxygenase activity K00485 dimethylaniline monooxygenase (N-oxide forming)[1.14.13.8] hsa00982 Drug metabolism - cytochrome P450 - Homo sapiens (human) 1:147175351-147243050 43 45 61 95 84 149 0.32355162845903 0.307728860569726 0.413824172882557 0.640459162206908 0.518585123765983 1.05072283403757 0.348368220637104 0.736589040003487 -1.08024690870249 0.00235732057666627 0.0123487363565178 DOWN ENSG00000231887 PRH1 proline-rich protein HaeIII subfamily 1 [Source:HGNC Symbol;Acc:HGNC:9366] - - - - - - 12:10824960-11171544 0 2 1 5 11 5 0 0.0349387511299291 0.0173219233206099 0.0861065771543888 0.173479591490003 0.0900813162062479 0.0174202248168463 0.116555828283547 -2.74218599923245 0.00237944428848561 0.0124406181766111 DOWN ENSG00000279013 RP11-254A24.2 - - - - - - - 4:91603275-91605292 0 0 0 3 1 9 0 0 0 0.0942073829110413 0.0287726598534948 0.295660171035612 0 0.139546737933383 -Inf 0.0023810149256704 0.0124466502523138 DOWN ENSG00000272505 RP11-981G7.6 - - - - - - - 8:10486807-10489666 0 0 0 2 5 3 0 0 0 0.0443222745502341 0.10146849483353 0.0695305021444595 0 0.0717737571760745 -Inf 0.00239541542959711 0.01250924646533 DOWN ENSG00000250483 PPM1AP1 protein phosphatase, Mg2+/Mn2+ dependent 1A pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:30175] - - - - - - 8:15806149-15807283 0 0 0 3 5 2 0 0 0 0.167498236752847 0.255682727069512 0.11680307555545 0 0.179994679792603 -Inf 0.00239919818926051 0.0125241585490791 DOWN ENSG00000271980 CTD-2256P15.4 - - - - - - - 5:10264597-10267146 13 9 4 2 3 0 0.36061547011788 0.226908291517449 0.1000440031321 0.0497104726328115 0.0682868868251467 0 0.229189254922476 0.0393324531526527 2.54274733319064 0.00241268234588463 0.0125879445568053 UP ENSG00000148248 SURF4 surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476] GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0050794|GO:0043229|GO:0042175|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0051130|GO:0051128|GO:0043231|GO:0005737|GO:0005783|GO:0016021|GO:0010256|GO:0005794|GO:0006996|GO:0005793|GO:0007030|GO:0033116|GO:0033043|GO:0000139|GO:0010638 cell|membrane|cellular process|binding|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|positive regulation of cellular component organization|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane|endomembrane system organization|Golgi apparatus|organelle organization|endoplasmic reticulum-Golgi intermediate compartment|Golgi organization|endoplasmic reticulum-Golgi intermediate compartment membrane|regulation of organelle organization|Golgi membrane|positive regulation of organelle organization - - - - 9:133361449-133376166 1111 3949 1096 5052 5340 5407 10.1588244464937 32.8168162592402 9.03554069064725 41.3895159656289 40.0625439445705 46.3355758717785 17.3370604654604 42.5958785939926 -1.29685454047028 0.00242364079163336 0.0126384929595498 DOWN ENSG00000164591 MYOZ3 myozenin 3 [Source:HGNC Symbol;Acc:HGNC:18565] GO:0005623|GO:0005488|GO:0043229|GO:0005622|GO:0005515|GO:0030017|GO:0030018|GO:0005737|GO:0031674|GO:0043292|GO:0030016 cell|binding|intracellular organelle|intracellular|protein binding|sarcomere|Z disc|cytoplasm|I band|contractile fiber|myofibril - - - - 5:150660874-150679365 5 4 6 1 1 0 0.0319339964983093 0.0232167938169265 0.0345493239418816 0.00571946492423366 0.00524225601158834 0 0.0299000380857058 0.00365390697860733 3.03263551075819 0.0024307072708323 0.0126687037121905 UP ENSG00000140009 ESR2 estrogen receptor 2 (ER beta) [Source:HGNC Symbol;Acc:HGNC:3468] GO:0032502|GO:0040007|GO:0032991|GO:0004871|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0036094|GO:0051716|GO:0042995|GO:0007631|GO:0097159|GO:0004872|GO:0009892|GO:0014823|GO:0003700|GO:0048523|GO:0048521|GO:0008283|GO:0050794|GO:0042562|GO:0043229|GO:0006807|GO:0006950|GO:0016049|GO:0044702|GO:0071704|GO:0043167|GO:0008144|GO:0009628|GO:0042698|GO:0044237|GO:0050795|GO:0038023|GO:0003006|GO:0023051|GO:0000989|GO:0045926|GO:0044297|GO:0016043|GO:0043227|GO:0044708|GO:0008289|GO:0071944|GO:0040008|GO:0009605|GO:0004879|GO:0023057|GO:0009893|GO:0032504|GO:0009058|GO:0032993|GO:0005622|GO:0022602|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0048609|GO:0019222|GO:0098531|GO:0045137|GO:0042127|GO:0003712|GO:0006725|GO:0003707|GO:0009888|GO:0048468|GO:0043025|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0003676|GO:0005496|GO:0048513|GO:0050877|GO:0009414|GO:0005102|GO:0034641|GO:0030902|GO:0006952|GO:0030900|GO:0031325|GO:0046483|GO:0051128|GO:0007420|GO:0010942|GO:0044849|GO:0060009|GO:0043231|GO:0043178|GO:0048608|GO:0001541|GO:0043169|GO:0019899|GO:0021854|GO:0030308|GO:0005737|GO:0000981|GO:0007267|GO:0001662|GO:0060322|GO:0021764|GO:0072593|GO:0043005|GO:0009966|GO:0043204|GO:0007548|GO:0050673|GO:1903524|GO:0009890|GO:0036477|GO:0060008|GO:0060548|GO:0042493|GO:0010646|GO:0006139|GO:0038052|GO:0008406|GO:0007154|GO:0022037|GO:0033555|GO:0060259|GO:0007165|GO:0009968|GO:0071000|GO:1990239|GO:0009725|GO:2000252|GO:0008219|GO:0007611|GO:0008285|GO:1902074|GO:0021549|GO:0060011|GO:0048869|GO:0010035|GO:0009967|GO:0044249|GO:0030850|GO:0019538|GO:0023014|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0021536|GO:0048732|GO:0003013|GO:0030547|GO:0051090|GO:0009636|GO:0003713|GO:0000165|GO:1902533|GO:0032268|GO:0003677|GO:0035150|GO:1903924|GO:0010468|GO:0034645|GO:0048660|GO:1901215|GO:0034698|GO:0008584|GO:0046872|GO:0007166|GO:0033993|GO:0043412|GO:0008585|GO:0046661|GO:0061458|GO:0007417|GO:0001655|GO:0010629|GO:0042596|GO:0002064|GO:0051252|GO:0070997|GO:0048659|GO:0021761|GO:0046545|GO:1900116|GO:0042975|GO:0010628|GO:0036211|GO:2000377|GO:0051091|GO:1903925|GO:0031981|GO:1901184|GO:0051247|GO:0048471|GO:0005654|GO:0071259|GO:0005739|GO:2000378|GO:0050678|GO:0030284|GO:0050680|GO:1901214|GO:0032270|GO:0012501|GO:0014070|GO:0060429|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0007399|GO:0071310|GO:0050890|GO:0031328|GO:0051246|GO:0035690|GO:0048019|GO:0009059|GO:0030154|GO:0017085|GO:0009755|GO:0043068|GO:1902531|GO:0016070|GO:0031667|GO:0008015|GO:0032870|GO:1901186|GO:0010557|GO:0045909|GO:0005634|GO:0043067|GO:0048662|GO:0048545|GO:0097305|GO:0030522|GO:0046546|GO:0043401|GO:0044752|GO:0000975|GO:0045893|GO:0031401|GO:0045742|GO:0042312|GO:0043065|GO:0030855|GO:0043408|GO:0045892|GO:0043523|GO:0042058|GO:0032774|GO:0043565|GO:2001141|GO:0016310|GO:0043627|GO:1902679|GO:0070371|GO:0071383|GO:0071407|GO:0003690|GO:0030518|GO:0045471|GO:0007167|GO:0043410|GO:0032355|GO:0042981|GO:0046914|GO:0080184|GO:0051402|GO:0033574|GO:0033594|GO:0006464|GO:0071396|GO:0031960|GO:0071548|GO:0006351|GO:0006915|GO:0006355|GO:0050880|GO:0030520|GO:0051384|GO:0045944|GO:0006366|GO:1903507|GO:0006352|GO:0006357|GO:0033595|GO:0006468|GO:1903506|GO:0044212|GO:0042311|GO:0042325|GO:0070374|GO:0001932|GO:0071392|GO:0001934|GO:0071391|GO:0000122|GO:0070372|GO:0008270|GO:0042327|GO:0007169|GO:0006367|GO:0034056|GO:0001047|GO:0000976|GO:0038127|GO:0001046|GO:0007173 developmental process|growth|macromolecular complex|signal transducer activity|reproduction|behavior|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|small molecule binding|cellular response to stimulus|cell projection|feeding behavior|organic cyclic compound binding|receptor activity|negative regulation of metabolic process|response to activity|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|negative regulation of behavior|cell proliferation|regulation of cellular process|hormone binding|intracellular organelle|nitrogen compound metabolic process|response to stress|cell growth|single organism reproductive process|organic substance metabolic process|ion binding|drug binding|response to abiotic stimulus|ovulation cycle|cellular metabolic process|regulation of behavior|signaling receptor activity|developmental process involved in reproduction|regulation of signaling|transcription factor activity, transcription factor binding|negative regulation of growth|cell body|cellular component organization|membrane-bounded organelle|single-organism behavior|lipid binding|cell periphery|regulation of growth|response to external stimulus|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding|negative regulation of signaling|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|protein-DNA complex|intracellular|ovulation cycle process|protein binding|plasma membrane|anatomical structure development|cilium|multicellular organismal reproductive process|regulation of metabolic process|transcription factor activity, direct ligand regulated sequence-specific DNA binding|development of primary sexual characteristics|regulation of cell proliferation|transcription cofactor activity|cellular aromatic compound metabolic process|steroid hormone receptor activity|tissue development|cell development|neuronal cell body|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|nucleic acid binding|steroid binding|animal organ development|neurological system process|response to water deprivation|receptor binding|cellular nitrogen compound metabolic process|hindbrain development|defense response|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|brain development|positive regulation of cell death|estrous cycle|Sertoli cell development|intracellular membrane-bounded organelle|alcohol binding|reproductive structure development|ovarian follicle development|cation binding|enzyme binding|hypothalamus development|negative regulation of cell growth|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cell-cell signaling|behavioral fear response|head development|amygdala development|reactive oxygen species metabolic process|neuron projection|regulation of signal transduction|perikaryon|sex differentiation|epithelial cell proliferation|positive regulation of blood circulation|negative regulation of biosynthetic process|somatodendritic compartment|Sertoli cell differentiation|negative regulation of cell death|response to drug|regulation of cell communication|nucleobase-containing compound metabolic process|RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding|gonad development|cell communication|metencephalon development|multicellular organismal response to stress|regulation of feeding behavior|signal transduction|negative regulation of signal transduction|response to magnetism|steroid hormone binding|response to hormone|negative regulation of feeding behavior|cell death|learning or memory|negative regulation of cell proliferation|response to salt|cerebellum development|Sertoli cell proliferation|cellular developmental process|response to inorganic substance|positive regulation of signal transduction|cellular biosynthetic process|prostate gland development|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|diencephalon development|gland development|circulatory system process|receptor inhibitor activity|regulation of sequence-specific DNA binding transcription factor activity|response to toxic substance|transcription coactivator activity|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|DNA binding|regulation of tube size|estradiol binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|negative regulation of neuron death|response to gonadotropin|male gonad development|metal ion binding|cell surface receptor signaling pathway|response to lipid|macromolecule modification|female gonad development|male sex differentiation|reproductive system development|central nervous system development|urogenital system development|negative regulation of gene expression|fear response|epithelial cell development|regulation of RNA metabolic process|neuron death|smooth muscle cell proliferation|limbic system development|development of primary female sexual characteristics|extracellular negative regulation of signal transduction|peroxisome proliferator activated receptor binding|positive regulation of gene expression|protein modification process|regulation of reactive oxygen species metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|response to bisphenol A|nuclear lumen|regulation of ERBB signaling pathway|positive regulation of protein metabolic process|perinuclear region of cytoplasm|nucleoplasm|cellular response to magnetism|mitochondrion|negative regulation of reactive oxygen species metabolic process|regulation of epithelial cell proliferation|estrogen receptor activity|negative regulation of epithelial cell proliferation|regulation of neuron death|positive regulation of cellular protein metabolic process|programmed cell death|response to organic cyclic compound|epithelium development|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|nervous system development|cellular response to organic substance|cognition|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|cellular response to drug|receptor antagonist activity|macromolecule biosynthetic process|cell differentiation|response to insecticide|hormone-mediated signaling pathway|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|blood circulation|cellular response to hormone stimulus|positive regulation of ERBB signaling pathway|positive regulation of macromolecule biosynthetic process|positive regulation of vasodilation|nucleus|regulation of programmed cell death|negative regulation of smooth muscle cell proliferation|response to steroid hormone|response to alcohol|intracellular receptor signaling pathway|development of primary male sexual characteristics|steroid hormone mediated signaling pathway|response to human chorionic gonadotropin|regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|positive regulation of epidermal growth factor receptor signaling pathway|regulation of vasodilation|positive regulation of apoptotic process|epithelial cell differentiation|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|regulation of neuron apoptotic process|regulation of epidermal growth factor receptor signaling pathway|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|phosphorylation|response to estrogen|negative regulation of RNA biosynthetic process|ERK1 and ERK2 cascade|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|double-stranded DNA binding|intracellular steroid hormone receptor signaling pathway|response to ethanol|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|response to estradiol|regulation of apoptotic process|transition metal ion binding|response to phenylpropanoid|neuron apoptotic process|response to testosterone|response to hydroxyisoflavone|cellular protein modification process|cellular response to lipid|response to corticosteroid|response to dexamethasone|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of blood vessel size|intracellular estrogen receptor signaling pathway|response to glucocorticoid|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|response to genistein|protein phosphorylation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|vasodilation|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|regulation of protein phosphorylation|cellular response to estradiol stimulus|positive regulation of protein phosphorylation|cellular response to estrogen stimulus|negative regulation of transcription from RNA polymerase II promoter|regulation of ERK1 and ERK2 cascade|zinc ion binding|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|transcription initiation from RNA polymerase II promoter|estrogen response element binding|core promoter binding|transcription regulatory region sequence-specific DNA binding|ERBB signaling pathway|core promoter sequence-specific DNA binding|epidermal growth factor receptor signaling pathway K08551 estrogen receptor beta[-] hsa04915|hsa04917 Estrogen signaling pathway - Homo sapiens (human)|Prolactin signaling pathway - Homo sapiens (human) 14:64084232-64338112 3 3 3 11 9 19 0.0157548674425762 0.0143190803129002 0.0142009339925226 0.0517524548711424 0.038774891460429 0.0935023528822988 0.0147582939159997 0.0613432330712901 -2.05537825226591 0.00243640373508433 0.0126895319447327 DOWN ENSG00000213949 ITGA1 integrin subunit alpha 1 [Source:HGNC Symbol;Acc:HGNC:6134] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0042995|GO:0045178|GO:0030055|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0050900|GO:0043167|GO:0009986|GO:0044237|GO:0048870|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0009893|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0048856|GO:0019222|GO:0042127|GO:0050817|GO:0006935|GO:0009897|GO:0045123|GO:0048468|GO:0043025|GO:0010941|GO:0098797|GO:0007275|GO:0005102|GO:0005924|GO:0043062|GO:0005912|GO:0031982|GO:0031325|GO:0010942|GO:0030141|GO:0005887|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0009611|GO:0043235|GO:0006928|GO:0032403|GO:0043005|GO:0031589|GO:0009966|GO:0043204|GO:0036477|GO:0010646|GO:0031226|GO:0043085|GO:0007154|GO:0016477|GO:0007165|GO:0001669|GO:0009968|GO:0070062|GO:0008219|GO:0008285|GO:0030595|GO:0050790|GO:0030030|GO:0048869|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0098857|GO:0031323|GO:0050878|GO:0003013|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0035150|GO:0006936|GO:0046872|GO:0007166|GO:0043412|GO:0031410|GO:0051345|GO:0007596|GO:1901216|GO:0070997|GO:0005518|GO:0000904|GO:0016023|GO:0051347|GO:0036211|GO:0007160|GO:0042060|GO:0019902|GO:0060326|GO:1901184|GO:0007599|GO:0051247|GO:0031988|GO:1901185|GO:1901214|GO:0008305|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0097485|GO:0030198|GO:0051246|GO:0030154|GO:0048858|GO:0045121|GO:0043068|GO:1902531|GO:0008015|GO:0043067|GO:0005925|GO:0071621|GO:0048666|GO:0030182|GO:0007411|GO:0016311|GO:0031401|GO:1990266|GO:0043065|GO:0034665|GO:0043408|GO:0043523|GO:0010922|GO:0042058|GO:0043525|GO:0016310|GO:0007229|GO:0030593|GO:0061564|GO:0019903|GO:0007167|GO:0042059|GO:0043410|GO:0042981|GO:0051402|GO:0098639|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0043549|GO:0006915|GO:0050880|GO:0010921|GO:0033674|GO:0006470|GO:0035304|GO:0045859|GO:0045860|GO:0043406|GO:0007409|GO:0006468|GO:0048699|GO:0035307|GO:0043666|GO:0042311|GO:0032516|GO:0043405|GO:0042325|GO:0001932|GO:0001934|GO:0035306|GO:0042327|GO:0035303|GO:0007169|GO:0000187|GO:0071902|GO:0071900|GO:0032147|GO:0038127|GO:0007173 locomotion|developmental process|macromolecular complex|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|cell projection|basal part of cell|cell-substrate junction|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|leukocyte migration|ion binding|cell surface|cellular metabolic process|cell motility|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|coagulation|chemotaxis|external side of plasma membrane|cellular extravasation|cell development|neuronal cell body|regulation of cell death|plasma membrane protein complex|multicellular organism development|receptor binding|cell-substrate adherens junction|extracellular structure organization|adherens junction|vesicle|positive regulation of cellular metabolic process|positive regulation of cell death|secretory granule|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|muscle system process|response to wounding|receptor complex|movement of cell or subcellular component|protein complex binding|neuron projection|cell-substrate adhesion|regulation of signal transduction|perikaryon|somatodendritic compartment|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|cell communication|cell migration|signal transduction|acrosomal vesicle|negative regulation of signal transduction|extracellular exosome|cell death|negative regulation of cell proliferation|leukocyte chemotaxis|regulation of catalytic activity|cell projection organization|cellular developmental process|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|membrane microdomain|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|regulation of tube size|muscle contraction|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|cytoplasmic vesicle|positive regulation of hydrolase activity|blood coagulation|positive regulation of neuron death|neuron death|collagen binding|cell morphogenesis involved in differentiation|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|protein modification process|cell-matrix adhesion|wound healing|phosphatase binding|cell chemotaxis|regulation of ERBB signaling pathway|hemostasis|positive regulation of protein metabolic process|membrane-bounded vesicle|negative regulation of ERBB signaling pathway|regulation of neuron death|integrin complex|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|neuron projection guidance|extracellular matrix organization|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|membrane raft|positive regulation of programmed cell death|regulation of intracellular signal transduction|blood circulation|regulation of programmed cell death|focal adhesion|granulocyte chemotaxis|neuron development|neuron differentiation|axon guidance|dephosphorylation|positive regulation of protein modification process|neutrophil migration|positive regulation of apoptotic process|integrin alpha1-beta1 complex|regulation of MAPK cascade|regulation of neuron apoptotic process|positive regulation of phosphatase activity|regulation of epidermal growth factor receptor signaling pathway|positive regulation of neuron apoptotic process|phosphorylation|integrin-mediated signaling pathway|neutrophil chemotaxis|axon development|protein phosphatase binding|enzyme linked receptor protein signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of MAPK cascade|regulation of apoptotic process|neuron apoptotic process|collagen binding involved in cell-matrix adhesion|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|apoptotic process|regulation of blood vessel size|regulation of phosphatase activity|positive regulation of kinase activity|protein dephosphorylation|regulation of protein dephosphorylation|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|axonogenesis|protein phosphorylation|generation of neurons|positive regulation of protein dephosphorylation|regulation of phosphoprotein phosphatase activity|vasodilation|positive regulation of phosphoprotein phosphatase activity|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of dephosphorylation|positive regulation of phosphorylation|regulation of dephosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|activation of MAPK activity|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K06480 integrin alpha 1[-] hsa04151|hsa04810|hsa04510|hsa05414|hsa04640|hsa05410|hsa04512|hsa05412 PI3K-Akt signaling pathway - Homo sapiens (human)|Regulation of actin cytoskeleton - Homo sapiens (human)|Focal adhesion - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|ECM-receptor interaction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 5:52787896-52959210 13 30 49 60 72 98 0.0388972314538554 0.0815794197526367 0.13218664292155 0.160852879319233 0.176758623757728 0.274812793368351 0.0842210980426807 0.204141432148437 -1.27731542861871 0.00245880456307275 0.0127905822313946 DOWN ENSG00000184588 PDE4B phosphodiesterase 4B [Source:HGNC Symbol;Acc:HGNC:8781] GO:0040011|GO:0032991|GO:0002376|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0042995|GO:0008021|GO:0097159|GO:0050794|GO:0060076|GO:0043229|GO:0006807|GO:0071704|GO:0050900|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0001776|GO:0048870|GO:0051707|GO:0043227|GO:0071944|GO:0002262|GO:0009607|GO:0009605|GO:0016787|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0030017|GO:0030018|GO:0002757|GO:1901078|GO:0006935|GO:0006725|GO:0044325|GO:0000930|GO:0006810|GO:1901360|GO:0098797|GO:0034641|GO:0043168|GO:0016788|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0001817|GO:0043231|GO:0043169|GO:0030133|GO:0010243|GO:0005737|GO:0032970|GO:0003012|GO:0001816|GO:0006928|GO:0001780|GO:0042592|GO:0043005|GO:0043197|GO:0036477|GO:0014069|GO:0031674|GO:0001819|GO:0042493|GO:0006139|GO:0009617|GO:0050776|GO:0055086|GO:1902495|GO:0007154|GO:0055085|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0008092|GO:0030595|GO:0000166|GO:0016021|GO:0030029|GO:0010033|GO:0003013|GO:0015631|GO:0030551|GO:0005829|GO:0005813|GO:0006936|GO:0046872|GO:0007166|GO:0030552|GO:0033993|GO:1901898|GO:0044309|GO:0032623|GO:0031410|GO:0002237|GO:0019693|GO:0005815|GO:0030048|GO:0090257|GO:0071417|GO:0016023|GO:0071869|GO:0070382|GO:0071219|GO:0048872|GO:0006811|GO:0002429|GO:0032743|GO:0005891|GO:0043292|GO:0060326|GO:0071867|GO:0030425|GO:0031988|GO:0034765|GO:0034702|GO:0002764|GO:0043269|GO:0014070|GO:0006796|GO:0090075|GO:0032609|GO:0071310|GO:0017076|GO:0019439|GO:0035690|GO:0032729|GO:0008015|GO:0046434|GO:0005856|GO:0032496|GO:0042578|GO:0022898|GO:0071621|GO:0032649|GO:0034220|GO:0006941|GO:0008016|GO:0098655|GO:0070252|GO:0030016|GO:1990266|GO:0008081|GO:0006937|GO:0009259|GO:0009117|GO:0060047|GO:0034703|GO:0006812|GO:0030554|GO:0002768|GO:1901077|GO:0086004|GO:0071407|GO:0030593|GO:0032412|GO:0071871|GO:0015630|GO:0055119|GO:0006163|GO:0009166|GO:0043015|GO:0050851|GO:0071396|GO:0071870|GO:0071222|GO:0086003|GO:1903169|GO:0006195|GO:0004112|GO:0009154|GO:0006942|GO:0060048|GO:0034704|GO:0055117|GO:1901019|GO:0071872|GO:0009187|GO:1901897|GO:0030001|GO:0051924|GO:0050852|GO:2001257|GO:0009214|GO:1901385|GO:0070588|GO:0046058|GO:0004114|GO:0006198|GO:1901841|GO:0006816|GO:0004115 locomotion|macromolecular complex|immune system process|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|cell projection|synaptic vesicle|organic cyclic compound binding|regulation of cellular process|excitatory synapse|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|leukocyte migration|catabolic process|ion binding|immune response|cellular metabolic process|leukocyte homeostasis|cell motility|response to other organism|membrane-bounded organelle|cell periphery|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|hydrolase activity|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|protein complex|endomembrane system|sarcomere|Z disc|immune response-activating signal transduction|negative regulation of relaxation of muscle|chemotaxis|cellular aromatic compound metabolic process|ion channel binding|gamma-tubulin complex|transport|organic cyclic compound metabolic process|plasma membrane protein complex|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|regulation of cytokine production|intracellular membrane-bounded organelle|cation binding|transport vesicle|response to organonitrogen compound|cytoplasm|regulation of actin filament-based process|muscle system process|cytokine production|movement of cell or subcellular component|neutrophil homeostasis|homeostatic process|neuron projection|dendritic spine|somatodendritic compartment|postsynaptic density|I band|positive regulation of cytokine production|response to drug|nucleobase-containing compound metabolic process|response to bacterium|regulation of immune response|nucleobase-containing small molecule metabolic process|transmembrane transporter complex|cell communication|transmembrane transport|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|cytoskeletal protein binding|leukocyte chemotaxis|nucleotide binding|integral component of membrane|actin filament-based process|response to organic substance|circulatory system process|tubulin binding|cyclic nucleotide binding|cytosol|centrosome|muscle contraction|metal ion binding|cell surface receptor signaling pathway|cAMP binding|response to lipid|negative regulation of relaxation of cardiac muscle|neuron spine|interleukin-2 production|cytoplasmic vesicle|response to molecule of bacterial origin|ribose phosphate metabolic process|microtubule organizing center|actin filament-based movement|regulation of muscle system process|cellular response to organonitrogen compound|cytoplasmic, membrane-bounded vesicle|response to catecholamine|exocytic vesicle|cellular response to molecule of bacterial origin|homeostasis of number of cells|ion transport|immune response-activating cell surface receptor signaling pathway|positive regulation of interleukin-2 production|voltage-gated calcium channel complex|contractile fiber|cell chemotaxis|response to monoamine|dendrite|membrane-bounded vesicle|regulation of ion transmembrane transport|ion channel complex|immune response-regulating signaling pathway|regulation of ion transport|response to organic cyclic compound|phosphate-containing compound metabolic process|relaxation of muscle|interferon-gamma production|cellular response to organic substance|purine nucleotide binding|aromatic compound catabolic process|cellular response to drug|positive regulation of interferon-gamma production|blood circulation|organophosphate catabolic process|cytoskeleton|response to lipopolysaccharide|phosphoric ester hydrolase activity|regulation of transmembrane transporter activity|granulocyte chemotaxis|regulation of interferon-gamma production|ion transmembrane transport|striated muscle contraction|regulation of heart contraction|cation transmembrane transport|actin-mediated cell contraction|myofibril|neutrophil migration|phosphoric diester hydrolase activity|regulation of muscle contraction|ribonucleotide metabolic process|nucleotide metabolic process|heart contraction|cation channel complex|cation transport|adenyl nucleotide binding|immune response-regulating cell surface receptor signaling pathway|regulation of relaxation of muscle|regulation of cardiac muscle cell contraction|cellular response to organic cyclic compound|neutrophil chemotaxis|regulation of ion transmembrane transporter activity|response to epinephrine|microtubule cytoskeleton|relaxation of cardiac muscle|purine nucleotide metabolic process|nucleotide catabolic process|gamma-tubulin binding|antigen receptor-mediated signaling pathway|cellular response to lipid|cellular response to catecholamine stimulus|cellular response to lipopolysaccharide|cardiac muscle cell contraction|regulation of calcium ion transmembrane transport|purine nucleotide catabolic process|cyclic-nucleotide phosphodiesterase activity|purine ribonucleotide catabolic process|regulation of striated muscle contraction|cardiac muscle contraction|calcium channel complex|regulation of cardiac muscle contraction|regulation of calcium ion transmembrane transporter activity|cellular response to epinephrine stimulus|cyclic nucleotide metabolic process|regulation of relaxation of cardiac muscle|metal ion transport|regulation of calcium ion transport|T cell receptor signaling pathway|regulation of cation channel activity|cyclic nucleotide catabolic process|regulation of voltage-gated calcium channel activity|calcium ion transmembrane transport|cAMP metabolic process|3',5'-cyclic-nucleotide phosphodiesterase activity|cAMP catabolic process|regulation of high voltage-gated calcium channel activity|calcium ion transport|3',5'-cyclic-AMP phosphodiesterase activity K13293 cAMP-specific phosphodiesterase 4[3.1.4.53] hsa04024|hsa00230|hsa05032 cAMP signaling pathway - Homo sapiens (human)|Purine metabolism - Homo sapiens (human)|Morphine addiction - Homo sapiens (human) 1:65792514-66374579 51 58 33 19 34 10 0.202139147348499 0.208923825885921 0.117926953645693 0.0674737569576868 0.11056636508287 0.0371450647463205 0.176329975626704 0.0717283955956258 1.29766148345421 0.0024673208383028 0.0128282135915564 UP ENSG00000273013 CTD-2002J20.1 - - - - - - - 3:196474801-196475394 4 5 16 0 2 2 0.476320289213233 0.541190126352218 1.7179273265108 0 0.195401235386821 0.223184327871105 0.911812580692084 0.139528521085975 2.70817726073546 0.00246732774310702 0.0128282135915564 UP ENSG00000178821 TMEM52 transmembrane protein 52 [Source:HGNC Symbol;Acc:HGNC:27916] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 1:1917590-1919273 28 32 75 14 23 23 0.482603806895107 0.501265513287091 1.16551017963521 0.216211485500898 0.32526145734668 0.371535987801833 0.716459833272469 0.30433631021647 1.23521935390292 0.00246883504370004 0.0128338153220653 UP ENSG00000279672 CMB9-55F22.1 - - - - - - - 11:779617-780755 2 3 2 6 20 10 0.0796997892373691 0.108671735715537 0.0718625937991138 0.214245135572399 0.653938850448817 0.373480546776103 0.0867447062506733 0.413888177599106 -2.25439341720057 0.00246967452743911 0.0128359441751684 DOWN ENSG00000243444 PALM2 paralemmin 2 [Source:HGNC Symbol;Acc:HGNC:15845] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0050794|GO:0009653|GO:0016043|GO:0071944|GO:0050793|GO:0005886|GO:0048856|GO:0008360|GO:0051128|GO:0048869|GO:0000902|GO:0022604 developmental process|cell|membrane|cellular process|regulation of cellular process|anatomical structure morphogenesis|cellular component organization|cell periphery|regulation of developmental process|plasma membrane|anatomical structure development|regulation of cell shape|regulation of cellular component organization|cellular developmental process|cell morphogenesis|regulation of cell morphogenesis - - - - 9:109640788-109946703 0 0 2 6 2 15 0 0 0.0182823712187799 0.0545055347056053 0.0166358511996233 0.142529341288029 0.0060941237395933 0.0712235757310859 -3.54686416805959 0.00251409059749785 0.0130418176711904 DOWN ENSG00000153246 PLA2R1 phospholipase A2 receptor 1 [Source:HGNC Symbol;Acc:HGNC:9042] GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0004872|GO:0009892|GO:0050794|GO:0051050|GO:0006950|GO:0009986|GO:0051051|GO:0044237|GO:0023051|GO:0030246|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0032369|GO:0006810|GO:2001022|GO:0043270|GO:0031982|GO:0033554|GO:0005887|GO:0019899|GO:0001816|GO:0043235|GO:0072593|GO:0009966|GO:0006979|GO:0010646|GO:0031226|GO:0007154|GO:0044092|GO:0007165|GO:0070062|GO:0051047|GO:0050790|GO:0051048|GO:0043086|GO:0048869|GO:0016021|GO:0009967|GO:0010876|GO:0032370|GO:0043271|GO:0007568|GO:0016192|GO:1902533|GO:2000193|GO:0043274|GO:0006811|GO:0043517|GO:0051046|GO:0007569|GO:2001020|GO:0032368|GO:0034599|GO:0006869|GO:0051346|GO:0043269|GO:0032304|GO:0035556|GO:0046903|GO:0032305|GO:1902531|GO:0090398|GO:0006974|GO:0006820|GO:0015711|GO:1901798|GO:0090238|GO:1900139|GO:0090403|GO:0072331|GO:0042770|GO:0015908|GO:0046942|GO:1901796|GO:0060192|GO:0044070|GO:0090399|GO:2000191|GO:0006897|GO:0046717|GO:0043516|GO:0090400|GO:0015718|GO:0010519|GO:0090237|GO:0010517|GO:0006898|GO:0030330|GO:0015909|GO:1900138|GO:0050482|GO:0032429 developmental process|macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|receptor activity|negative regulation of metabolic process|regulation of cellular process|positive regulation of transport|response to stress|cell surface|negative regulation of transport|cellular metabolic process|regulation of signaling|carbohydrate binding|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|protein complex|regulation of metabolic process|negative regulation of lipid transport|transport|positive regulation of response to DNA damage stimulus|positive regulation of ion transport|vesicle|cellular response to stress|integral component of plasma membrane|enzyme binding|cytokine production|receptor complex|reactive oxygen species metabolic process|regulation of signal transduction|response to oxidative stress|regulation of cell communication|intrinsic component of plasma membrane|cell communication|negative regulation of molecular function|signal transduction|extracellular exosome|positive regulation of secretion|regulation of catalytic activity|negative regulation of secretion|negative regulation of catalytic activity|cellular developmental process|integral component of membrane|positive regulation of signal transduction|lipid localization|positive regulation of lipid transport|negative regulation of ion transport|aging|vesicle-mediated transport|positive regulation of intracellular signal transduction|positive regulation of fatty acid transport|phospholipase binding|ion transport|positive regulation of DNA damage response, signal transduction by p53 class mediator|regulation of secretion|cell aging|regulation of response to DNA damage stimulus|regulation of lipid transport|cellular response to oxidative stress|lipid transport|negative regulation of hydrolase activity|regulation of ion transport|negative regulation of icosanoid secretion|intracellular signal transduction|secretion|positive regulation of icosanoid secretion|regulation of intracellular signal transduction|cellular senescence|cellular response to DNA damage stimulus|anion transport|organic anion transport|positive regulation of signal transduction by p53 class mediator|positive regulation of arachidonic acid secretion|negative regulation of arachidonic acid secretion|oxidative stress-induced premature senescence|signal transduction by p53 class mediator|signal transduction in response to DNA damage|fatty acid transport|carboxylic acid transport|regulation of signal transduction by p53 class mediator|negative regulation of lipase activity|regulation of anion transport|replicative senescence|regulation of fatty acid transport|endocytosis|acid secretion|regulation of DNA damage response, signal transduction by p53 class mediator|stress-induced premature senescence|monocarboxylic acid transport|negative regulation of phospholipase activity|regulation of arachidonic acid secretion|regulation of phospholipase activity|receptor-mediated endocytosis|DNA damage response, signal transduction by p53 class mediator|long-chain fatty acid transport|negative regulation of phospholipase A2 activity|arachidonic acid secretion|regulation of phospholipase A2 activity K06560 mannose receptor, C type[-] hsa05152|hsa04145 Tuberculosis - Homo sapiens (human)|Phagosome - Homo sapiens (human) 2:159932006-160062610 7 1 8 7 20 65 0.0482431869750199 0.00626634126431599 0.0497100950870721 0.0432223216233262 0.113088606736813 0.419830240018988 0.034739874442136 0.192047056126376 -2.46679540414411 0.00252183408236211 0.0130729006242123 DOWN ENSG00000267607 CTD-2369P2.8 - - - - - - - 19:10285801-10289019 20 19 12 8 5 6 0.439495967664554 0.37946230635607 0.237756018627077 0.157516875071351 0.0901521886374327 0.123574087920693 0.352238097549234 0.123747717209826 1.50914904550478 0.00253444840971319 0.0131337307452834 UP ENSG00000254667 AP000783.1 - - - - - - - 11:123430737-123435710 22 20 21 8 4 13 1.43959726716793 1.18940429378482 1.23895071022582 0.469053488302199 0.214742523255822 0.797276339880794 1.28931742372619 0.493690783812938 1.38492787367733 0.00256943710759731 0.0132919728660908 UP ENSG00000245750 DRAIC downregulated RNA in cancer, inhibitor of cell invasion and migration [Source:HGNC Symbol;Acc:HGNC:27082] - - - - - - 15:69463026-69571440 0 0 0 1 5 6 0 0 0 0.0158888370957642 0.0727865300285668 0.0997705013836745 0 0.0628152895026685 -Inf 0.00257611636265133 0.0133219085208025 DOWN ENSG00000135747 ZNF670-ZNF695 ZNF670-ZNF695 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:49200] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 1:246945547-247078811 18 26 17 12 6 6 0.370352063413574 0.486175059353056 0.315355878349989 0.221224616428742 0.10128126860364 0.115702440086303 0.390627667038873 0.146069441706228 1.41913974249199 0.00257812660548192 0.0133299950952645 UP ENSG00000133067 LGR6 leucine-rich repeat containing G protein-coupled receptor 6 [Source:HGNC Symbol;Acc:HGNC:19719] GO:0040011|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0040012|GO:0043229|GO:0038023|GO:0048870|GO:0023051|GO:0040017|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0051272|GO:0031982|GO:2000147|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0006928|GO:0009966|GO:0010646|GO:0031226|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0016021|GO:2000145|GO:0009967|GO:0005794|GO:0030111|GO:0007186|GO:0005802|GO:0007166|GO:0030334|GO:0000139|GO:0030177|GO:0030335|GO:0004930|GO:0016055|GO:0060828|GO:0090263|GO:0032588|GO:0060070 locomotion|signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|regulation of locomotion|intracellular organelle|signaling receptor activity|cell motility|regulation of signaling|positive regulation of locomotion|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|positive regulation of cellular component movement|vesicle|positive regulation of cell motility|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|intrinsic component of plasma membrane|cell communication|regulation of cellular component movement|cell migration|signal transduction|integral component of membrane|regulation of cell motility|positive regulation of signal transduction|Golgi apparatus|regulation of Wnt signaling pathway|G-protein coupled receptor signaling pathway|trans-Golgi network|cell surface receptor signaling pathway|regulation of cell migration|Golgi membrane|positive regulation of Wnt signaling pathway|positive regulation of cell migration|G-protein coupled receptor activity|Wnt signaling pathway|regulation of canonical Wnt signaling pathway|positive regulation of canonical Wnt signaling pathway|trans-Golgi network membrane|canonical Wnt signaling pathway - - - - 1:202193901-202319781 0 3 1 6 6 12 0 0.0230071959559969 0.0076031342819471 0.0453584345945859 0.0415320850977236 0.0948830464316578 0.010203443412648 0.0605911887079891 -2.57005190068172 0.00257877235484917 0.0133310250877346 DOWN ENSG00000261011 RP11-96C23.11 - - - - - - - 10:87001636-87009905 0 0 0 5 0 9 0 0 0 0.182110462027673 0 0.342897830545899 0 0.175002764191191 -Inf 0.00258462419301159 0.0133566506245747 DOWN ENSG00000273148 RP5-1068E13.7 - - - - - - - 20:18794529-18796067 11 12 8 27 24 34 0.505589553544032 0.501265513287091 0.331529834940681 1.11192395144803 0.905091779425033 1.46458571139962 0.446128300590601 1.16053381409089 -1.37925798370844 0.00258455208078759 0.0133566506245747 DOWN ENSG00000278273 RP11-763B22.11 - - - - - - - 1:144661200-144679513 0 0 0 2 3 5 0 0 0 0.107607559604134 0.147819661633382 0.281408526009331 0 0.178945249082282 -Inf 0.00258613410539368 0.0133621404607862 DOWN ENSG00000274317 RP11-93G5.1 - - - - - - - 13:37934565-38048169 0 0 0 6 5 1 0 0 0 0.0766858470742102 0.0585198417471054 0.0133667564786687 0 0.0495241484333281 -Inf 0.00260712828568637 0.013461295026095 DOWN ENSG00000046653 GPM6B glycoprotein M6B [Source:HGNC Symbol;Acc:HGNC:4461] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0048523|GO:0050794|GO:0051051|GO:0051641|GO:0023051|GO:0016043|GO:0007155|GO:0071944|GO:1903828|GO:0023057|GO:0031224|GO:0050793|GO:0005886|GO:0048856|GO:0060341|GO:0050804|GO:0009888|GO:0006810|GO:0007275|GO:0048513|GO:0043062|GO:0030155|GO:0051128|GO:0022607|GO:0070169|GO:0032970|GO:0007267|GO:0032880|GO:1901888|GO:0031589|GO:0045184|GO:2000009|GO:0010646|GO:0008104|GO:0007154|GO:0045778|GO:0030278|GO:0001503|GO:0051649|GO:0001505|GO:0050805|GO:0048869|GO:0016021|GO:0030029|GO:0051589|GO:0098857|GO:0043271|GO:0006996|GO:0098657|GO:0006836|GO:0030501|GO:0045216|GO:0032956|GO:0007010|GO:0015844|GO:0015031|GO:0031214|GO:0007160|GO:0006811|GO:0034329|GO:0010810|GO:0085029|GO:0030036|GO:0043269|GO:0034613|GO:0033043|GO:0007399|GO:0030198|GO:0030154|GO:0045121|GO:1903827|GO:0001504|GO:0030282|GO:0051580|GO:0030500|GO:2000008|GO:0006820|GO:0051610|GO:0006837|GO:0051612|GO:0034332|GO:0006812|GO:0015696|GO:0034394|GO:0051493|GO:0001952|GO:0007044|GO:0048041|GO:0044070|GO:0051893|GO:0034333|GO:0015672|GO:0007268 developmental process|signaling|cell|membrane|cellular process|negative regulation of cellular process|regulation of cellular process|negative regulation of transport|cellular localization|regulation of signaling|cellular component organization|cell adhesion|cell periphery|negative regulation of cellular protein localization|negative regulation of signaling|intrinsic component of membrane|regulation of developmental process|plasma membrane|anatomical structure development|regulation of cellular localization|modulation of synaptic transmission|tissue development|transport|multicellular organism development|animal organ development|extracellular structure organization|regulation of cell adhesion|regulation of cellular component organization|cellular component assembly|positive regulation of biomineral tissue development|regulation of actin filament-based process|cell-cell signaling|regulation of protein localization|regulation of cell junction assembly|cell-substrate adhesion|establishment of protein localization|negative regulation of protein localization to cell surface|regulation of cell communication|protein localization|cell communication|positive regulation of ossification|regulation of ossification|ossification|establishment of localization in cell|regulation of neurotransmitter levels|negative regulation of synaptic transmission|cellular developmental process|integral component of membrane|actin filament-based process|negative regulation of neurotransmitter transport|membrane microdomain|negative regulation of ion transport|organelle organization|import into cell|neurotransmitter transport|positive regulation of bone mineralization|cell-cell junction organization|regulation of actin cytoskeleton organization|cytoskeleton organization|monoamine transport|protein transport|biomineral tissue development|cell-matrix adhesion|ion transport|cell junction assembly|regulation of cell-substrate adhesion|extracellular matrix assembly|actin cytoskeleton organization|regulation of ion transport|cellular protein localization|regulation of organelle organization|nervous system development|extracellular matrix organization|cell differentiation|membrane raft|regulation of cellular protein localization|neurotransmitter uptake|bone mineralization|regulation of neurotransmitter uptake|regulation of bone mineralization|regulation of protein localization to cell surface|anion transport|serotonin uptake|serotonin transport|negative regulation of serotonin uptake|adherens junction organization|cation transport|ammonium transport|protein localization to cell surface|regulation of cytoskeleton organization|regulation of cell-matrix adhesion|cell-substrate junction assembly|focal adhesion assembly|regulation of anion transport|regulation of focal adhesion assembly|adherens junction assembly|monovalent inorganic cation transport|synaptic transmission - - - - X:13771031-13938638 22 25 24 51 49 59 0.152285414013947 0.157276932834388 0.149780457928113 0.316305637110334 0.278293140552468 0.382752969423445 0.153114268258816 0.325783915695416 -1.08930664868555 0.00261411480794174 0.013489600987195 DOWN ENSG00000242588 RP11-274B21.14 - - - - - - - 7:128574751-128622694 18 58 74 110 118 132 1.15019909125191 3.36825972952668 4.26327222317012 6.29777535131313 6.18653718713459 7.90501053104356 2.92724368131624 6.79644102316376 -1.21523662315625 0.00263097773259331 0.0135563012131241 DOWN ENSG00000159784 FAM131B family with sequence similarity 131 member B [Source:HGNC Symbol;Acc:HGNC:22202] GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0043229|GO:0006950|GO:0009056|GO:0006914|GO:0016043|GO:0051707|GO:0043227|GO:0009607|GO:0009605|GO:0005622|GO:0002682|GO:0005515|GO:0050688|GO:0006952|GO:0033554|GO:0098542|GO:0043231|GO:0005737|GO:0009615|GO:0000422|GO:0016236|GO:0051607|GO:0006996|GO:1903008|GO:0098792|GO:0000423|GO:0007005|GO:0031981|GO:0005654|GO:0005634|GO:0050691|GO:0002230|GO:0098779 immune system process|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|intracellular organelle|response to stress|catabolic process|autophagy|cellular component organization|response to other organism|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|intracellular|regulation of immune system process|protein binding|regulation of defense response to virus|defense response|cellular response to stress|defense response to other organism|intracellular membrane-bounded organelle|cytoplasm|response to virus|mitophagy|macroautophagy|defense response to virus|organelle organization|organelle disassembly|xenophagy|macromitophagy|mitochondrion organization|nuclear lumen|nucleoplasm|nucleus|regulation of defense response to virus by host|positive regulation of defense response to virus by host|mitophagy in response to mitochondrial depolarization - - - - 7:143353400-143362770 0 0 1 5 5 4 0 0 0.00346231480201208 0.0172110262304139 0.0157623103157838 0.0144013351534883 0.00115410493400403 0.0157915572332287 -3.77430713653595 0.0026452419791593 0.0136203956615767 DOWN ENSG00000266028 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 [Source:HGNC Symbol;Acc:HGNC:19751] GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0007154|GO:0007165|GO:0031981|GO:0005654|GO:0005634 signaling|cell|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|cell communication|signal transduction|nuclear lumen|nucleoplasm|nucleus K07526 SLIT-ROBO Rho GTPase activating protein[-] hsa04360 Axon guidance - Homo sapiens (human) 1:206203345-206464443 260 215 983 1029 1206 1276 0.76437337429278 0.57444829274169 2.60555212909284 2.71047276730466 2.90902412058035 3.51570005948543 1.31479126537577 3.04506564912348 -1.21163955456299 0.00265261294165009 0.0136536390965555 DOWN ENSG00000214359 RPL18P10 ribosomal protein L18 pseudogene 10 [Source:HGNC Symbol;Acc:HGNC:35957] - - - - - - 13:50099331-50099868 9 7 7 0 3 2 1.18333679741252 0.83650843719583 0.829763921561572 0 0.323664612275324 0.24641541032609 0.949869718723307 0.190026674200471 2.32152770623536 0.00265403968129555 0.0136586279340454 UP ENSG00000270277 RP11-65L3.2 - - - - - - - 2:178548884-178550681 3 6 3 20 15 10 0.11803883165681 0.214529372900121 0.106396430374456 0.704979384830172 0.484204497036533 0.368702986945263 0.146321544977129 0.519295622937323 -1.82741385184259 0.00265777186347774 0.0136707651985294 DOWN ENSG00000151470 C4orf33 chromosome 4 open reading frame 33 [Source:HGNC Symbol;Acc:HGNC:27025] GO:0005488|GO:0005515 binding|protein binding - - - - 4:129093317-129116640 43 57 110 145 159 139 0.34046438987501 0.410164164222614 0.78524574374046 1.02864731318971 1.03291278406488 1.03143573712886 0.511958099279361 1.03099861146115 -1.00994474552501 0.00266815319944136 0.0137123507688281 DOWN ENSG00000230330 HMGN2P3 high mobility group nucleosomal binding domain 2 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:33566] - - - - - - 16:26032539-26032811 40 45 41 115 103 63 10.3643774352542 10.5969194806447 9.57802201221482 26.6980719269005 21.8972714352939 15.2985185935863 10.1797729760379 21.2979539852602 -1.06500945525035 0.00267535829875375 0.0137446475049035 DOWN ENSG00000204758 CTC-308K20.1 - - - - - - - 5:172954786-172959392 14 16 32 9 6 9 0.298924280779719 0.310472934882316 0.616006916855145 0.172168914686233 0.105102626459196 0.180091224011429 0.408468044172393 0.152454255052286 1.42184679886554 0.00268173885290162 0.0137697463943108 UP ENSG00000269982 RP11-1020A11.2 - - - - - - - 3:9958717-9962539 17 29 22 52 64 43 0.314544520165643 0.48766994113285 0.367002457644248 0.862065419600134 0.971598003564851 0.745655149095968 0.389738972980914 0.859772857420318 -1.14144736107933 0.00268876854238998 0.013796922664921 DOWN ENSG00000134207 SYT6 synaptotagmin 6 [Source:HGNC Symbol;Acc:HGNC:18638] GO:0000003|GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0030054|GO:0005488|GO:0019898|GO:0030672|GO:0008021|GO:0043229|GO:0044702|GO:0043167|GO:0019953|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0007340|GO:0012505|GO:0031090|GO:0042802|GO:0006810|GO:0032940|GO:0031982|GO:0030276|GO:0043231|GO:0043169|GO:0030133|GO:0005737|GO:0012506|GO:0046983|GO:0048306|GO:0030658|GO:0000149|GO:0005783|GO:0009566|GO:0060478|GO:0016021|GO:0016192|GO:0005829|GO:0046872|GO:0031410|GO:0046982|GO:0016023|GO:0006887|GO:0070382|GO:0007338|GO:0048471|GO:0031988|GO:0030659|GO:0046903|GO:0019905|GO:0097038|GO:0042803|GO:0045055|GO:0005509|GO:0017156 reproduction|synapse|cell|membrane|cellular process|reproductive process|cell junction|binding|extrinsic component of membrane|synaptic vesicle membrane|synaptic vesicle|intracellular organelle|single organism reproductive process|ion binding|sexual reproduction|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|acrosome reaction|endomembrane system|organelle membrane|identical protein binding|transport|secretion by cell|vesicle|clathrin binding|intracellular membrane-bounded organelle|cation binding|transport vesicle|cytoplasm|vesicle membrane|protein dimerization activity|calcium-dependent protein binding|transport vesicle membrane|SNARE binding|endoplasmic reticulum|fertilization|acrosomal vesicle exocytosis|integral component of membrane|vesicle-mediated transport|cytosol|metal ion binding|cytoplasmic vesicle|protein heterodimerization activity|cytoplasmic, membrane-bounded vesicle|exocytosis|exocytic vesicle|single fertilization|perinuclear region of cytoplasm|membrane-bounded vesicle|cytoplasmic vesicle membrane|secretion|syntaxin binding|perinuclear endoplasmic reticulum|protein homodimerization activity|regulated exocytosis|calcium ion binding|calcium ion regulated exocytosis - - - - 1:114089291-114153919 14 17 12 38 34 35 0.0752420712827236 0.0830355994531265 0.0581474414192799 0.182981938979462 0.149922345968241 0.176286518403111 0.07214170405171 0.169730267783605 -1.23433845541117 0.00269347686144127 0.01381870737609 DOWN ENSG00000254233 RP11-242J7.1 - - - - - - - 4:184584093-184625030 3 5 5 0 1 0 0.112770360955868 0.170811336372592 0.169424487676248 0 0.0308518743806336 0 0.151002061668236 0.0102839581268779 3.87610070095731 0.00270159547376115 0.0138579778820731 UP ENSG00000223764 RP11-54O7.3 - - - - - - - 1:916865-921016 12 13 13 27 26 52 0.137557772861267 0.135434346408325 0.134351207548275 0.277305292704345 0.244531612762097 0.558626131930603 0.135781108939289 0.360154345799015 -1.40733253952442 0.00270597054445914 0.013878035498073 DOWN ENSG00000261150 EPPK1 epiplakin 1 [Source:HGNC Symbol;Acc:HGNC:15577] GO:0005623|GO:0043229|GO:0005622|GO:0005856 cell|intracellular organelle|intracellular|cytoskeleton - - - - 8:143857324-143878464 2056 2238 2200 1224 1743 359 4.6122974767923 4.56283028672158 4.44970326123665 2.46021612152962 3.20818528558698 0.754774333823344 4.54161034158351 2.14105858031331 1.0848796628125 0.00271364163244453 0.0139078209948496 UP ENSG00000280334 RP11-361L15.5 - - - - - - - 16:67006672-67009481 15 22 29 13 7 8 0.377593087080756 0.503316955779192 0.658195777127339 0.293209617360437 0.144579440940807 0.188738960773006 0.513035273329096 0.20884267302475 1.29664149128606 0.00272884991060203 0.0139809653734534 UP ENSG00000155761 SPAG17 sperm associated antigen 17 [Source:HGNC Symbol;Acc:HGNC:26620] GO:0032502|GO:0005623|GO:0009987|GO:0005488|GO:0042995|GO:0043229|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0005930|GO:0005874|GO:0022607|GO:0043231|GO:0031514|GO:0005737|GO:0006928|GO:0030030|GO:0048869|GO:0007017|GO:0006996|GO:0000902|GO:0007010|GO:0035082|GO:1990716|GO:0044782|GO:0031981|GO:0030031|GO:0007018|GO:0005654|GO:0070925|GO:0042384|GO:0032990|GO:0048858|GO:0000226|GO:0005856|GO:0005634|GO:0060271|GO:0015630|GO:0001578|GO:0003341 developmental process|cell|cellular process|binding|cell projection|intracellular organelle|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|axoneme|microtubule|cellular component assembly|intracellular membrane-bounded organelle|motile cilium|cytoplasm|movement of cell or subcellular component|cell projection organization|cellular developmental process|microtubule-based process|organelle organization|cell morphogenesis|cytoskeleton organization|axoneme assembly|axonemal central apparatus|cilium organization|nuclear lumen|cell projection assembly|microtubule-based movement|nucleoplasm|organelle assembly|cilium assembly|cell part morphogenesis|cell projection morphogenesis|microtubule cytoskeleton organization|cytoskeleton|nucleus|cilium morphogenesis|microtubule cytoskeleton|microtubule bundle formation|cilium movement - - - - 1:117953861-118185223 13 10 20 7 6 2 0.0756100517020716 0.0528591531648327 0.104880861694974 0.0364770522234682 0.0286305707498203 0.0109004679127969 0.0777833555206261 0.0253360302953618 1.61827097541831 0.00273441141057334 0.0140070552936267 UP ENSG00000234332 BCAS2P2 breast carcinoma amplified sequence 2 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:39595] - - - - - - 1:100393033-100394026 52 47 28 27 19 10 5.45748376283572 4.48298757028803 2.6494342842051 2.53894801376634 1.63610734912645 0.983572656569114 4.19663520577628 1.71954267315397 1.28720814276645 0.00273710927416371 0.0140184697668354 UP ENSG00000244567 AC096772.6 - - - - - - - 2:207821290-207822769 14 10 36 47 44 74 0.78473545342568 0.509408098883276 1.81928932133752 2.36038343518476 2.0235164089396 3.88730571212738 1.03781095788216 2.75706851875058 -1.40959144771361 0.00276166343627145 0.0141321049411121 DOWN ENSG00000166532 RIMKLB ribosomal modification protein rimK-like family member B [Source:HGNC Symbol;Acc:HGNC:29228] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0043167|GO:0044237|GO:0016874|GO:0005622|GO:0043168|GO:0001882|GO:0043169|GO:0005737|GO:0000166|GO:0019538|GO:0046872|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0072591|GO:0044267|GO:0017076|GO:0072590|GO:0005524|GO:0030554|GO:0006464 cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|ion binding|cellular metabolic process|ligase activity|intracellular|anion binding|nucleoside binding|cation binding|cytoplasm|nucleotide binding|protein metabolic process|metal ion binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|citrate-L-glutamate ligase activity|cellular protein metabolic process|purine nucleotide binding|N-acetyl-L-aspartate-L-glutamate ligase activity|ATP binding|adenyl nucleotide binding|cellular protein modification process K18310 beta-citrylglutamate/N-acetylaspartylglutamate synthase[6.3.2.41] hsa01100 Metabolic pathways - Homo sapiens (human) 12:8681600-8783095 50 34 48 78 93 118 0.207486253039191 0.128227635262722 0.179589331660713 0.290010216396631 0.316646445581805 0.458917352403869 0.171767739987542 0.355191338127435 -1.04813729310729 0.00276669365967275 0.0141529939197859 DOWN ENSG00000119125 GDA guanine deaminase [Source:HGNC Symbol;Acc:HGNC:4212] GO:0032502|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0016787|GO:0019239|GO:0005622|GO:0005515|GO:0048856|GO:0006725|GO:1901360|GO:0007275|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0008892|GO:0043169|GO:0005737|GO:0016810|GO:0006139|GO:0055086|GO:0070062|GO:0005829|GO:0046872|GO:0006796|GO:0007399|GO:0019439|GO:0016814|GO:0046434|GO:0009117|GO:0006145|GO:0006163|GO:0046914|GO:0006144|GO:0009166|GO:0046098|GO:0006195|GO:0006147|GO:0008270 developmental process|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|hydrolase activity|deaminase activity|intracellular|protein binding|anatomical structure development|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|guanine deaminase activity|cation binding|cytoplasm|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|extracellular exosome|cytosol|metal ion binding|phosphate-containing compound metabolic process|nervous system development|aromatic compound catabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|organophosphate catabolic process|nucleotide metabolic process|purine nucleobase catabolic process|purine nucleotide metabolic process|transition metal ion binding|purine nucleobase metabolic process|nucleotide catabolic process|guanine metabolic process|purine nucleotide catabolic process|guanine catabolic process|zinc ion binding K01487 guanine deaminase[3.5.4.3] hsa01100|hsa00230 Metabolic pathways - Homo sapiens (human)|Purine metabolism - Homo sapiens (human) 9:72114595-72257193 21 17 103 111 149 173 0.106099865247826 0.0780597500180024 0.469178807569256 0.50246769699425 0.617648821065409 0.819144652907169 0.217779474278361 0.646420390322276 -1.56960471995715 0.0027806804963709 0.0142123669814513 DOWN ENSG00000278156 TSC22D1-AS1 TSC22D1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:43684] - - - - - - 13:44575893-44580432 6 12 15 27 29 29 0.0942485848743039 0.171318593148753 0.212444460531609 0.380024641634136 0.373768159540326 0.42693718991895 0.159337212851555 0.393576663697804 -1.30456143720677 0.00278273856710835 0.0142204514177427 DOWN ENSG00000255036 RP11-23J9.4 - - - - - - - 9:97238497-97377287 16 20 23 34 39 95 0.13282516936035 0.150891449545991 0.172146675477942 0.25289107738767 0.2656352321157 0.7391059142281 0.151954431461428 0.419210741243823 -1.46403693393441 0.00278750914596977 0.0142423922717408 DOWN ENSG00000186952 TMEM232 transmembrane protein 232 [Source:HGNC Symbol;Acc:HGNC:37270] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 5:110289233-110738956 0 0 0 4 1 6 0 0 0 0.0211586889022983 0.00484587110535407 0.0331985469050835 0 0.019734368970912 -Inf 0.0027897209400048 0.014251254097006 DOWN ENSG00000134489 HRH4 histamine receptor H4 [Source:HGNC Symbol;Acc:HGNC:17383] GO:0004871|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0006950|GO:0071704|GO:0044237|GO:0038023|GO:0023051|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0019222|GO:0030594|GO:0006952|GO:0004888|GO:0005737|GO:0007267|GO:0042592|GO:0009966|GO:0019725|GO:0010646|GO:0007154|GO:0007165|GO:0016021|GO:0019538|GO:0023014|GO:0031323|GO:0000165|GO:0032268|GO:0005829|GO:0007186|GO:0043412|GO:0015464|GO:0048878|GO:0036211|GO:0006954|GO:0055082|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0051246|GO:1902531|GO:0004930|GO:0007200|GO:0007187|GO:0043408|GO:0016907|GO:0016310|GO:0007213|GO:0050801|GO:0008227|GO:0006464|GO:0006873|GO:0007207|GO:0007188|GO:0006468|GO:0042325|GO:0001932|GO:0007197|GO:0004969|GO:0030003|GO:0007268|GO:0007193|GO:0007271|GO:0055065|GO:0006875|GO:0006874|GO:0055074|GO:0051480|GO:0007204 signal transducer activity|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|response to stress|organic substance metabolic process|cellular metabolic process|signaling receptor activity|regulation of signaling|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|regulation of metabolic process|neurotransmitter receptor activity|defense response|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|homeostatic process|regulation of signal transduction|cellular homeostasis|regulation of cell communication|cell communication|signal transduction|integral component of membrane|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|macromolecule modification|acetylcholine receptor activity|chemical homeostasis|protein modification process|inflammatory response|cellular chemical homeostasis|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|regulation of protein metabolic process|regulation of intracellular signal transduction|G-protein coupled receptor activity|phospholipase C-activating G-protein coupled receptor signaling pathway|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|regulation of MAPK cascade|G-protein coupled acetylcholine receptor activity|phosphorylation|G-protein coupled acetylcholine receptor signaling pathway|ion homeostasis|G-protein coupled amine receptor activity|cellular protein modification process|cellular ion homeostasis|phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway|histamine receptor activity|cellular cation homeostasis|synaptic transmission|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|synaptic transmission, cholinergic|metal ion homeostasis|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04152 histamine receptor H4[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 18:24460629-24479957 10 10 16 3 3 6 0.154541321713273 0.140457290974589 0.222951459896748 0.041536049533424 0.0380449118208705 0.0869095453390235 0.17265002419487 0.0554968355644393 1.63737312007457 0.00279181692469869 0.0142595213806595 UP ENSG00000228801 RP11-110G21.1 - - - - - - - 8:51899325-51947173 30 40 42 21 16 21 0.771662963415945 0.935088030241011 0.974040522002993 0.48398758023182 0.337674469784402 0.506233340521049 0.89359717188665 0.442631796845757 1.01351752776212 0.00279696743398912 0.0142833844978295 UP ENSG00000103546 SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:11048] GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0042995|GO:0022857|GO:0005326|GO:0006950|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0006810|GO:0005887|GO:0007267|GO:0043005|GO:0022891|GO:0005328|GO:0031226|GO:0007154|GO:0055085|GO:0033555|GO:0016021|GO:0006836|GO:0015844|GO:0008504|GO:0005334|GO:0015075|GO:0048265|GO:0005333|GO:0015293|GO:0008324|GO:0022890|GO:0015874|GO:0007268|GO:0015077|GO:0046873|GO:0015081 transporter activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cell projection|transmembrane transporter activity|neurotransmitter transporter activity|response to stress|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|transport|integral component of plasma membrane|cell-cell signaling|neuron projection|substrate-specific transmembrane transporter activity|neurotransmitter:sodium symporter activity|intrinsic component of plasma membrane|cell communication|transmembrane transport|multicellular organismal response to stress|integral component of membrane|neurotransmitter transport|monoamine transport|monoamine transmembrane transporter activity|norepinephrine:sodium symporter activity|ion transmembrane transporter activity|response to pain|norepinephrine transmembrane transporter activity|symporter activity|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|norepinephrine transport|synaptic transmission|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|sodium ion transmembrane transporter activity - - - - 16:55655604-55706192 2 6 6 20 14 14 0.0128012963438902 0.0349039736199816 0.0346274827599567 0.114700292636381 0.0735260571972975 0.0839871024150626 0.0274442509079428 0.090737817416247 -1.72519999647228 0.002798401219274 0.0142882623567994 DOWN ENSG00000102878 HSF4 heat shock transcription factor 4 [Source:HGNC Symbol;Acc:HGNC:5227] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0045595|GO:0003712|GO:0006725|GO:0048468|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0050877|GO:0034641|GO:0031325|GO:0046483|GO:0006482|GO:0022607|GO:0045597|GO:0043231|GO:0019899|GO:0007423|GO:0070988|GO:0009890|GO:0006139|GO:0048869|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0001654|GO:0043412|GO:0010629|GO:0051252|GO:0006325|GO:0010628|GO:0036211|GO:0019902|GO:0007600|GO:0031981|GO:0005654|GO:0006461|GO:0016577|GO:0044267|GO:0010467|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0010557|GO:0005634|GO:0045893|GO:0050953|GO:0051259|GO:0045892|GO:0043010|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0019903|GO:0070076|GO:0016568|GO:0006464|GO:0006351|GO:0006355|GO:0033169|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0070206|GO:0000122|GO:0051260|GO:0007601|GO:0070207 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|regulation of cell differentiation|transcription cofactor activity|cellular aromatic compound metabolic process|cell development|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|animal organ development|neurological system process|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|protein demethylation|cellular component assembly|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|sensory organ development|demethylation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular developmental process|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|eye development|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|chromatin organization|positive regulation of gene expression|protein modification process|phosphatase binding|sensory perception|nuclear lumen|nucleoplasm|protein complex assembly|histone demethylation|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of transcription, DNA-templated|sensory perception of light stimulus|protein oligomerization|negative regulation of transcription, DNA-templated|camera-type eye development|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|protein phosphatase binding|histone lysine demethylation|chromatin modification|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|histone H3-K9 demethylation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|protein trimerization|negative regulation of transcription from RNA polymerase II promoter|protein homooligomerization|visual perception|protein homotrimerization - - - - 16:67164681-67169945 63 50 95 154 113 173 0.412633923986624 0.297626398514211 0.560995191555874 0.903734325036326 0.607249701012416 1.0619300264216 0.423751838018903 0.857638017490114 -1.01714923325115 0.00281251043980855 0.0143480325820308 DOWN ENSG00000278530 CHMP1B2P charged multivesicular body protein 1B2, pseudogene [Source:HGNC Symbol;Acc:HGNC:49380] - - - - - - X:80228489-80335364 2 1 0 8 7 7 0.0197717855899832 0.00898920010299642 0 0.0708660825792701 0.0567810243247613 0.0648596414247978 0.00958699523099321 0.0641689161096097 -2.74272399479947 0.00281921544847743 0.0143797809668282 DOWN ENSG00000213123 TCTEX1D2 Tctex1 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:28482] GO:0005488|GO:0005515 binding|protein binding - - - - 3:196291219-196318299 17 23 21 10 11 6 0.636919332941343 0.783177104065926 0.709378028471459 0.335703668468404 0.338138186802548 0.210691201809698 0.709824821826243 0.294844352360217 1.2675094646979 0.00282567938396907 0.0144102890893428 UP ENSG00000255222 SETP17 SET pseudogene 17 [Source:HGNC Symbol;Acc:HGNC:42936] - - - - - - 11:86294760-86295576 3 5 2 0 0 0 0.259772116669454 0.393472380726092 0.156127422268577 0 0 0 0.269790639888041 0 Inf 0.00282886182360142 0.0144240548047475 UP ENSG00000128849 CGNL1 cingulin-like 1 [Source:HGNC Symbol;Acc:HGNC:25931] GO:0032991|GO:0005623|GO:0008152|GO:0030054|GO:0003824|GO:0043229|GO:0005911|GO:0016787|GO:0005622|GO:0043234|GO:0016817|GO:0016459|GO:0043296|GO:0016818|GO:0005923|GO:0005856|GO:0015629|GO:0016462|GO:0017111|GO:0003774 macromolecular complex|cell|metabolic process|cell junction|catalytic activity|intracellular organelle|cell-cell junction|hydrolase activity|intracellular|protein complex|hydrolase activity, acting on acid anhydrides|myosin complex|apical junction complex|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|bicellular tight junction|cytoskeleton|actin cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|motor activity - - - - 15:57375967-57550727 7 3 31 23 54 92 0.0568113895263428 0.0221308319062733 0.22683412548431 0.16724730964332 0.35957750097861 0.699754963171694 0.101925448972309 0.408859924597875 -2.00409234874248 0.00287671057685247 0.0146480159579317 DOWN ENSG00000259030 FPGT-TNNI3K FPGT-TNNI3K readthrough [Source:HGNC Symbol;Acc:HGNC:42952] GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0071704|GO:0043167|GO:0044237|GO:0005515|GO:0016740|GO:0043168|GO:0001882|GO:0016772|GO:0000166|GO:0019538|GO:0035639|GO:0043412|GO:0001883|GO:0036211|GO:0032549|GO:0016301|GO:0006796|GO:0044267|GO:0017076|GO:0016773|GO:0005524|GO:0030554|GO:0016310|GO:0004672|GO:0006464|GO:0006468 cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|organic substance metabolic process|ion binding|cellular metabolic process|protein binding|transferase activity|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|nucleotide binding|protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|protein modification process|ribonucleoside binding|kinase activity|phosphate-containing compound metabolic process|cellular protein metabolic process|purine nucleotide binding|phosphotransferase activity, alcohol group as acceptor|ATP binding|adenyl nucleotide binding|phosphorylation|protein kinase activity|cellular protein modification process|protein phosphorylation - - - - 1:74198235-74543982 2 0 4 5 7 28 0.0140400085248442 0 0.0253187979343841 0.0314482139666684 0.0403203879559019 0.184221161257177 0.0131196021530761 0.0853299210599158 -2.70132774191265 0.00287790474689036 0.0146515975978282 DOWN ENSG00000258830 RP11-123K3.4 - GO:0005488|GO:0097159|GO:0003676 binding|organic cyclic compound binding|nucleic acid binding - - - - 12:57249609-57296484 0 0 0 7 0 6 0 0 0 0.210552401111448 0 0.188792116287001 0 0.133114839132816 -Inf 0.00288853979135319 0.0146957169275832 DOWN ENSG00000259371 RP11-468E2.6 - GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - 14:24120956-24131829 0 0 0 7 0 6 0 0 0 0.5219222460492 0 0.467982340019659 0 0.329968195356286 -Inf 0.00289007284351628 0.0147010111893568 DOWN ENSG00000205754 SLCO1B7 solute carrier organic anion transporter family member 1B7 (non-functional) [Source:HGNC Symbol;Acc:HGNC:32934] GO:0005215|GO:0005623|GO:0016020|GO:0005488|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0006810|GO:0016021 transporter activity|cell|membrane|binding|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|transport|integral component of membrane K05043 solute carrier organic anion transporter family, member 1B[-] hsa04976 Bile secretion - Homo sapiens (human) 12:21015696-21092745 0 8 1 2 37 37 0 0.183415983107188 0.0227334799642812 0.045207455497029 0.765837902652678 0.874769845212973 0.0687164876904897 0.561938401120893 -3.03168379003385 0.00289577537359322 0.0147275090295148 DOWN ENSG00000260966 RP11-690D19.3 - - - - - - - 11:103050687-103055799 47 38 48 12 18 33 0.650233348510855 0.477785542539535 0.598724769702427 0.148752245507924 0.204317059598451 0.427872416285215 0.575581220250939 0.26031390713053 1.144767132374 0.00290332259453622 0.0147633780850425 UP ENSG00000235530 AC087294.2 - - - - - - - 17:21214331-21230035 0 1 3 7 8 7 0 0.0423421505838969 0.125938631871805 0.292056556380395 0.305682328260711 0.305510687553936 0.0560935941519006 0.301083190731681 -2.42425423501728 0.00290394531253903 0.0147640298638522 DOWN ENSG00000168993 CPLX1 complexin 1 [Source:HGNC Symbol;Acc:HGNC:2309] GO:0032991|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0050794|GO:0005326|GO:0016079|GO:0051641|GO:0044297|GO:0005622|GO:0007269|GO:0005515|GO:0043234|GO:0060341|GO:0031201|GO:0051640|GO:0043025|GO:0006810|GO:0043195|GO:0060627|GO:0032940|GO:0005737|GO:0007267|GO:0051656|GO:0043005|GO:0045184|GO:0036477|GO:0000149|GO:0008104|GO:0007154|GO:0051649|GO:0044306|GO:0001505|GO:0010817|GO:0016192|GO:0006836|GO:0051650|GO:0005829|GO:0030424|GO:0070032|GO:0015031|GO:0048489|GO:0006887|GO:0046907|GO:0042886|GO:0006811|GO:0043679|GO:0017157|GO:0051046|GO:0030425|GO:0009914|GO:0009306|GO:0046903|GO:0051648|GO:0019905|GO:0014047|GO:0070554|GO:0002790|GO:0030073|GO:0006820|GO:0015711|GO:0045055|GO:0015833|GO:0046942|GO:0016482|GO:0017075|GO:0006865|GO:0046717|GO:0046879|GO:0030072|GO:0006835|GO:0017156|GO:0007268 macromolecular complex|transporter activity|synapse|signaling|cell|membrane|cellular process|binding|cell projection|regulation of cellular process|neurotransmitter transporter activity|synaptic vesicle exocytosis|cellular localization|cell body|intracellular|neurotransmitter secretion|protein binding|protein complex|regulation of cellular localization|SNARE complex|organelle localization|neuronal cell body|transport|terminal bouton|regulation of vesicle-mediated transport|secretion by cell|cytoplasm|cell-cell signaling|establishment of organelle localization|neuron projection|establishment of protein localization|somatodendritic compartment|SNARE binding|protein localization|cell communication|establishment of localization in cell|neuron projection terminus|regulation of neurotransmitter levels|regulation of hormone levels|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|cytosol|axon|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|protein transport|synaptic vesicle transport|exocytosis|intracellular transport|amide transport|ion transport|axon terminus|regulation of exocytosis|regulation of secretion|dendrite|hormone transport|protein secretion|secretion|vesicle localization|syntaxin binding|glutamate secretion|synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex|peptide secretion|insulin secretion|anion transport|organic anion transport|regulated exocytosis|peptide transport|carboxylic acid transport|cytosolic transport|syntaxin-1 binding|amino acid transport|acid secretion|hormone secretion|peptide hormone secretion|dicarboxylic acid transport|calcium ion regulated exocytosis|synaptic transmission K15294 complexin-1/2[-] hsa04721 Synaptic vesicle cycle - Homo sapiens (human) 4:784957-826198 20 12 27 44 57 41 0.284540933208407 0.155158412097513 0.346334277903137 0.560879605086219 0.665356182338045 0.546675008897516 0.262011207736352 0.590970265440593 -1.17345701779272 0.00290658256556363 0.0147742583233934 DOWN ENSG00000275454 CTD-2026K11.4 - - - - - - - 15:75639760-75640976 4 3 6 1 0 0 0.232485005581479 0.158498217662349 0.314435753475991 0.0520532403457782 0 0 0.235139658906606 0.0173510801152594 3.76042050665041 0.00291333123156324 0.0148041856318449 UP ENSG00000167077 MEI1 meiotic double-stranded break formation protein 1 [Source:HGNC Symbol;Acc:HGNC:28613] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0044702|GO:0051321|GO:0019953|GO:0051641|GO:0003006|GO:0016043|GO:0090220|GO:0032504|GO:0048856|GO:0048609|GO:0007049|GO:0051640|GO:0048468|GO:0022402|GO:0051656|GO:0048515|GO:0070192|GO:0045141|GO:0007276|GO:0007126|GO:0051649|GO:0007059|GO:0048869|GO:0007281|GO:0006996|GO:0051276|GO:0007286|GO:0048232|GO:0007140|GO:0007127|GO:0045132|GO:0030154|GO:0051303|GO:0007283|GO:0045143|GO:0007141 developmental process|reproduction|cell|cellular process|reproductive process|binding|single organism reproductive process|meiotic cell cycle|sexual reproduction|cellular localization|developmental process involved in reproduction|cellular component organization|chromosome localization to nuclear envelope involved in homologous chromosome segregation|multicellular organism reproduction|anatomical structure development|multicellular organismal reproductive process|cell cycle|organelle localization|cell development|cell cycle process|establishment of organelle localization|spermatid differentiation|chromosome organization involved in meiotic cell cycle|meiotic telomere clustering|gamete generation|meiotic nuclear division|establishment of localization in cell|chromosome segregation|cellular developmental process|germ cell development|organelle organization|chromosome organization|spermatid development|male gamete generation|male meiosis|meiosis I|meiotic chromosome segregation|cell differentiation|establishment of chromosome localization|spermatogenesis|homologous chromosome segregation|male meiosis I - - - - 22:41699499-41799456 0 0 1 4 4 6 0 0 0.00693102944654175 0.0275658813120951 0.0252404770729089 0.0432516025896173 0.00231034314884725 0.0320193203248738 -3.79276363189213 0.00291543144303485 0.0148114307980878 DOWN ENSG00000251603 RP11-164P12.4 - - - - - - - 4:151667224-151670502 0 0 1 4 4 6 0 0 0.209686440196857 0.833958586932036 0.763607459340603 1.30850325334444 0.069895480065619 0.968689766539026 -3.79276363189213 0.00291574927314136 0.0148114307980878 DOWN ENSG00000250091 DNAH10OS dynein, axonemal, heavy chain 10 opposite strand [Source:HGNC Symbol;Acc:HGNC:37121] - - - - - - 12:123926424-123934984 3 4 11 11 17 41 0.0421098847855048 0.0510216683167218 0.139191507497417 0.138324864993881 0.195767464184813 0.539299234967947 0.0774410201998812 0.291130521382214 -1.91049623209879 0.00292392321710312 0.0148453747828906 DOWN ENSG00000281406 BLACAT1 bladder cancer associated transcript 1 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:48597] - - - - - - 1:205434886-205437879 100 93 248 283 278 395 2.36262110873781 1.99691032665709 5.28275097029476 5.99070546583827 5.38897885991249 8.74622034451153 3.21409413522989 6.70863489008743 -1.06160704510911 0.00293021977184907 0.0148748139889104 DOWN ENSG00000257176 RP11-996F15.2 - - - - - - - 12:29280418-29317848 0 2 5 8 12 10 0 0.0438372329212884 0.108713564884657 0.172876515804527 0.237459299102476 0.226023856299892 0.0508502659353151 0.212119890402298 -2.06055268400077 0.00293412408033248 0.0148895699973221 DOWN ENSG00000186517 ARHGAP30 Rho GTPase activating protein 30 [Source:HGNC Symbol;Acc:HGNC:27414] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0043229|GO:0023051|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0019222|GO:0008047|GO:0031982|GO:0043231|GO:0005737|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005829|GO:0005096|GO:0031410|GO:0051345|GO:0030695|GO:0016023|GO:0031988|GO:0035556|GO:1902531|GO:0043087|GO:0043547|GO:0051056|GO:0007264 signaling|cell|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|intracellular organelle|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of metabolic process|enzyme activator activity|vesicle|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cytosol|GTPase activator activity|cytoplasmic vesicle|positive regulation of hydrolase activity|GTPase regulator activity|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|intracellular signal transduction|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 1:161046946-161069970 56 37 60 10 11 39 0.276606264083789 0.166095985027822 0.267203154210535 0.0442572813398748 0.0445782345285392 0.180538834821801 0.236635134440715 0.0897914502300717 1.39801430800616 0.00293824450309405 0.0149028799516428 UP ENSG00000249931 GOLGA8K golgin A8 family member K [Source:HGNC Symbol;Acc:HGNC:38652] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0012505|GO:0043231|GO:0005737|GO:0005794 cell|intracellular organelle|membrane-bounded organelle|intracellular|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|Golgi apparatus - - - - 15:32392782-32403292 5 3 7 1 0 1 0.107835654029047 0.0588086374680117 0.136101521280526 0.0193136565551256 0 0.0202090687127189 0.100915270925862 0.0131742417559482 2.93735267069372 0.00293824204900972 0.0149028799516428 UP ENSG00000230047 AC017104.4 - - - - - - - 2:231437101-231437421 5 3 4 1 0 0 1.10187210347437 0.600910688146661 0.794742080955932 0.19734826635767 0 0 0.832508290858988 0.0657827554525567 3.66168329495329 0.00294837341290365 0.0149440984497157 UP ENSG00000250526 CCT6P2 chaperonin containing TCP1, subunit 6 (zeta) pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:35150] - - - - - - 5:14639426-14641018 13 14 10 4 6 3 0.57725640226026 0.564985705654095 0.400364419313958 0.159148405792429 0.218584432805596 0.124831912199092 0.514202175742771 0.167521583599039 1.61798872926467 0.00295127340843769 0.0149537196767649 UP ENSG00000268292 AC006547.15 - - - - - - - 22:20064552-20065705 4 6 6 16 16 18 0.485307464481407 0.66161888932147 0.656377893619693 1.73933022898338 1.59280410275661 2.04680008627741 0.601101415807523 1.79297813933913 -1.57667757519949 0.00295091330601593 0.0149537196767649 DOWN ENSG00000240463 RPS19P3 ribosomal protein S19 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:23560] - - - - - - 14:34568689-34569129 10 9 8 4 2 2 1.60393566775884 1.3120547468696 1.15697146479299 0.574883016842038 0.263193500725106 0.300615625295774 1.35765395980714 0.379564047620973 1.83870055929475 0.0029534458333522 0.0149621876648391 UP ENSG00000196748 CLPSL2 colipase like 2 [Source:HGNC Symbol;Acc:HGNC:21250] GO:0005576|GO:0008152|GO:0071704|GO:0009056|GO:0009893|GO:0030234|GO:0019222|GO:0008047|GO:0043085|GO:0006629|GO:0007586|GO:0050790|GO:0016042 extracellular region|metabolic process|organic substance metabolic process|catabolic process|positive regulation of metabolic process|enzyme regulator activity|regulation of metabolic process|enzyme activator activity|positive regulation of catalytic activity|lipid metabolic process|digestion|regulation of catalytic activity|lipid catabolic process - - - - 6:35776594-35779552 1 3 4 9 11 11 0.0788047810942248 0.214802150217236 0.284089318470884 0.635184425785623 0.710918593188431 0.812041999894544 0.192565416594115 0.719381672956199 -1.90140877721301 0.00295727137579631 0.0149790260693965 DOWN ENSG00000197748 CFAP43 cilia and flagella associated protein 43 [Source:HGNC Symbol;Acc:HGNC:26684] GO:0005623|GO:0005488|GO:0042995|GO:0005515 cell|binding|cell projection|protein binding - - - - 10:104129888-104232362 51 43 72 90 106 178 0.396437072827326 0.303778507039325 0.504602884291857 0.62682245933835 0.676047092515432 1.29674104714201 0.401606154719503 0.866536866331931 -1.10947975021664 0.00296977912742349 0.0150321780383352 DOWN ENSG00000205763 RP9P retinitis pigmentosa 9 pseudogene [Source:HGNC Symbol;Acc:HGNC:33969] - - - - - - 7:32916815-32943176 270 108 163 95 114 77 11.9219247118229 4.33397542106086 6.48908995497658 3.75839986511057 4.13006242104772 3.18641513410606 7.58166336262011 3.69162580675478 1.03825807518112 0.00297869761769157 0.0150661315590803 UP ENSG00000132881 RSG1 REM2 and RAB-like small GTPase 1 [Source:HGNC Symbol;Acc:HGNC:28127] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0043227|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048646|GO:0060341|GO:0006810|GO:0060627|GO:0043168|GO:0032940|GO:0001882|GO:0051128|GO:0022607|GO:0043231|GO:0005737|GO:0045184|GO:0036064|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0000166|GO:0030030|GO:0048869|GO:0006996|GO:0061025|GO:0016192|GO:0000902|GO:0016050|GO:0035639|GO:0005815|GO:0001883|GO:0015031|GO:0006887|GO:0044782|GO:0032549|GO:0017157|GO:0051046|GO:0031981|GO:0030031|GO:0005654|GO:0034613|GO:0070925|GO:0042384|GO:0035556|GO:0033043|GO:0032990|GO:0031338|GO:0046903|GO:0017076|GO:0048858|GO:0005856|GO:0005634|GO:0048284|GO:0060271|GO:0032561|GO:0006906|GO:0015630|GO:0005525|GO:0007264|GO:0019001 developmental process|signaling|cell|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|regulation of cellular process|intracellular organelle|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|intracellular|protein binding|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|regulation of cellular localization|transport|regulation of vesicle-mediated transport|anion binding|secretion by cell|nucleoside binding|regulation of cellular component organization|cellular component assembly|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|ciliary basal body|protein localization|cell communication|membrane organization|signal transduction|nucleotide binding|cell projection organization|cellular developmental process|organelle organization|membrane fusion|vesicle-mediated transport|cell morphogenesis|vesicle organization|purine ribonucleoside triphosphate binding|microtubule organizing center|purine nucleoside binding|protein transport|exocytosis|cilium organization|ribonucleoside binding|regulation of exocytosis|regulation of secretion|nuclear lumen|cell projection assembly|nucleoplasm|cellular protein localization|organelle assembly|cilium assembly|intracellular signal transduction|regulation of organelle organization|cell part morphogenesis|regulation of vesicle fusion|secretion|purine nucleotide binding|cell projection morphogenesis|cytoskeleton|nucleus|organelle fusion|cilium morphogenesis|guanyl ribonucleotide binding|vesicle fusion|microtubule cytoskeleton|GTP binding|small GTPase mediated signal transduction|guanyl nucleotide binding - - - - 1:16231700-16237162 11 5 13 22 30 29 0.48906494211456 0.202053384697182 0.521107040716786 0.87637626595746 1.09436910747608 1.20835836970775 0.404075122509509 1.05970124771376 -1.39096215805426 0.00299978075774488 0.0151532072321008 DOWN ENSG00000164136 IL15 interleukin 15 [Source:HGNC Symbol;Acc:HGNC:5977] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0009986|GO:0044237|GO:0023051|GO:0051707|GO:0007155|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0005615|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0045058|GO:0019222|GO:0006486|GO:0008284|GO:0044262|GO:0042127|GO:1903706|GO:0016337|GO:0045595|GO:0070661|GO:0048468|GO:0050867|GO:0009991|GO:0007275|GO:0050688|GO:0048513|GO:0070489|GO:0005102|GO:0006952|GO:0030155|GO:0031325|GO:0034105|GO:0098542|GO:0001817|GO:0098609|GO:0005887|GO:0045597|GO:0043231|GO:0005737|GO:0003012|GO:0001816|GO:0007267|GO:0031668|GO:0009611|GO:0005975|GO:0009615|GO:0002696|GO:0001775|GO:0009966|GO:0048771|GO:0001819|GO:0010646|GO:0031226|GO:0050776|GO:0046649|GO:0050865|GO:0045062|GO:0007154|GO:0007165|GO:0050778|GO:0045785|GO:0008285|GO:0051607|GO:0034103|GO:0014889|GO:0048869|GO:0016021|GO:0009967|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0005794|GO:0005768|GO:0007568|GO:0007584|GO:1902533|GO:0051249|GO:0032268|GO:0006109|GO:0005126|GO:0034645|GO:0048660|GO:0030101|GO:0032943|GO:0033993|GO:0043412|GO:0030097|GO:0030098|GO:1903020|GO:0050727|GO:0048535|GO:0032740|GO:0060050|GO:0034109|GO:0005125|GO:0048659|GO:0006493|GO:0009100|GO:0036211|GO:0031670|GO:0006954|GO:0033273|GO:0051251|GO:0022407|GO:0031981|GO:0007159|GO:0051247|GO:0050729|GO:0005654|GO:0070085|GO:0032270|GO:0042110|GO:0014070|GO:0006796|GO:0035556|GO:1901137|GO:0044267|GO:0051174|GO:0071310|GO:0031328|GO:0051246|GO:0014891|GO:0046651|GO:0009059|GO:0030154|GO:0022409|GO:0031669|GO:0048469|GO:1902531|GO:0031667|GO:0032620|GO:0010557|GO:0005634|GO:0060049|GO:0048662|GO:0097305|GO:0050691|GO:0002521|GO:0042098|GO:0009101|GO:0033280|GO:0043413|GO:0010560|GO:0031401|GO:0050863|GO:0032816|GO:0030217|GO:0014732|GO:0016310|GO:0045619|GO:0034112|GO:0071407|GO:0070486|GO:0046631|GO:0001779|GO:0001787|GO:0071295|GO:0010559|GO:0030203|GO:1904100|GO:0006464|GO:0050870|GO:0071396|GO:0045621|GO:0050671|GO:1903039|GO:0032946|GO:0007259|GO:0032825|GO:0006468|GO:0045580|GO:0046425|GO:0042325|GO:0032817|GO:0001932|GO:0018193|GO:0046427|GO:0001934|GO:0042129|GO:0071593|GO:0042327|GO:0042102|GO:0046633|GO:0032819|GO:0071305|GO:0050731|GO:0050730|GO:0030212|GO:0007260|GO:0042531|GO:0001866|GO:0018108|GO:0042516|GO:0042517|GO:0042506|GO:0042503 developmental process|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cell surface|cellular metabolic process|regulation of signaling|response to other organism|cell adhesion|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|extracellular space|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|plasma membrane|endomembrane system|anatomical structure development|T cell selection|regulation of metabolic process|protein glycosylation|positive regulation of cell proliferation|cellular carbohydrate metabolic process|regulation of cell proliferation|regulation of hemopoiesis|single organismal cell-cell adhesion|regulation of cell differentiation|leukocyte proliferation|cell development|positive regulation of cell activation|response to extracellular stimulus|multicellular organism development|regulation of defense response to virus|animal organ development|T cell aggregation|receptor binding|defense response|regulation of cell adhesion|positive regulation of cellular metabolic process|positive regulation of tissue remodeling|defense response to other organism|regulation of cytokine production|cell-cell adhesion|integral component of plasma membrane|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|muscle system process|cytokine production|cell-cell signaling|cellular response to extracellular stimulus|response to wounding|carbohydrate metabolic process|response to virus|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|tissue remodeling|positive regulation of cytokine production|regulation of cell communication|intrinsic component of plasma membrane|regulation of immune response|lymphocyte activation|regulation of cell activation|extrathymic T cell selection|cell communication|signal transduction|positive regulation of immune response|positive regulation of cell adhesion|negative regulation of cell proliferation|defense response to virus|regulation of tissue remodeling|muscle atrophy|cellular developmental process|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|endosome|aging|response to nutrient|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|regulation of carbohydrate metabolic process|cytokine receptor binding|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|natural killer cell activation|mononuclear cell proliferation|response to lipid|macromolecule modification|hemopoiesis|lymphocyte differentiation|positive regulation of glycoprotein metabolic process|regulation of inflammatory response|lymph node development|positive regulation of interleukin-17 production|positive regulation of protein glycosylation|homotypic cell-cell adhesion|cytokine activity|smooth muscle cell proliferation|protein O-linked glycosylation|glycoprotein metabolic process|protein modification process|cellular response to nutrient|inflammatory response|response to vitamin|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|nuclear lumen|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|positive regulation of inflammatory response|nucleoplasm|glycosylation|positive regulation of cellular protein metabolic process|T cell activation|response to organic cyclic compound|phosphate-containing compound metabolic process|intracellular signal transduction|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|striated muscle atrophy|lymphocyte proliferation|macromolecule biosynthetic process|cell differentiation|positive regulation of cell-cell adhesion|cellular response to nutrient levels|cell maturation|regulation of intracellular signal transduction|response to nutrient levels|interleukin-17 production|positive regulation of macromolecule biosynthetic process|nucleus|regulation of protein glycosylation|negative regulation of smooth muscle cell proliferation|response to alcohol|regulation of defense response to virus by host|leukocyte differentiation|T cell proliferation|glycoprotein biosynthetic process|response to vitamin D|macromolecule glycosylation|positive regulation of glycoprotein biosynthetic process|positive regulation of protein modification process|regulation of T cell activation|positive regulation of natural killer cell activation|T cell differentiation|skeletal muscle atrophy|phosphorylation|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|cellular response to organic cyclic compound|leukocyte aggregation|alpha-beta T cell activation|natural killer cell differentiation|natural killer cell proliferation|cellular response to vitamin|regulation of glycoprotein biosynthetic process|glycosaminoglycan metabolic process|positive regulation of protein O-linked glycosylation|cellular protein modification process|positive regulation of T cell activation|cellular response to lipid|positive regulation of lymphocyte differentiation|positive regulation of lymphocyte proliferation|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|JAK-STAT cascade|positive regulation of natural killer cell differentiation|protein phosphorylation|regulation of T cell differentiation|regulation of JAK-STAT cascade|regulation of phosphorylation|regulation of natural killer cell proliferation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of JAK-STAT cascade|positive regulation of protein phosphorylation|regulation of T cell proliferation|lymphocyte aggregation|positive regulation of phosphorylation|positive regulation of T cell proliferation|alpha-beta T cell proliferation|positive regulation of natural killer cell proliferation|cellular response to vitamin D|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|hyaluronan metabolic process|tyrosine phosphorylation of STAT protein|positive regulation of tyrosine phosphorylation of STAT protein|NK T cell proliferation|peptidyl-tyrosine phosphorylation|regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|tyrosine phosphorylation of Stat5 protein|tyrosine phosphorylation of Stat3 protein K05433 interleukin 15[-] hsa04060|hsa05166|hsa05168|hsa04630|hsa04668|hsa05323|hsa04672 Cytokine-cytokine receptor interaction - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human)|Herpes simplex infection - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|TNF signaling pathway - Homo sapiens (human)|Rheumatoid arthritis - Homo sapiens (human)|Intestinal immune network for IgA production - Homo sapiens (human) 4:141636599-141733987 23 23 57 73 70 98 0.129391708225795 0.117594907943094 0.289108385659461 0.367953073387054 0.323101820457824 0.516689140132114 0.178698333942783 0.402581344658997 -1.17175413654687 0.00302146758171636 0.0152498551453187 DOWN ENSG00000262154 EIF1P4 eukaryotic translation initiation factor 1 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:49617] - - - - - - 16:2822659-2822993 27 26 31 16 15 11 5.70121071947404 4.98946225091286 5.90174996334701 3.02695380148451 2.59880503185578 2.17675736091135 5.53080764457797 2.60083873141721 1.0885132218117 0.00303395400073962 0.0153051136765936 UP ENSG00000280007 AC008079.10 - - - - - - - 22:18110759-18131154 10 5 12 19 28 31 0.0346801151932561 0.0157612735366355 0.0375238587939087 0.0590411914308608 0.079676059824214 0.100761922617713 0.0293217491746001 0.0798263912909293 -1.4448946233821 0.00303545274183421 0.0153100872030273 DOWN ENSG00000149021 SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) [Source:HGNC Symbol;Acc:HGNC:12523] GO:0032502|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0002683|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0044237|GO:0051707|GO:0007155|GO:0043227|GO:0009607|GO:0009605|GO:0009058|GO:0005615|GO:0030234|GO:0005622|GO:0002682|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0001818|GO:0042127|GO:0016337|GO:0004857|GO:0006725|GO:0070661|GO:1901360|GO:0007275|GO:0009410|GO:0070489|GO:0034641|GO:0006952|GO:0030155|GO:0031982|GO:0046483|GO:0007566|GO:0001817|GO:0098609|GO:0030141|GO:0043231|GO:0097160|GO:0005737|GO:0001816|GO:0009611|GO:0005635|GO:0001775|GO:0009890|GO:0006979|GO:0042493|GO:0006139|GO:0009617|GO:0007162|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0007565|GO:0007165|GO:0005783|GO:0070062|GO:0009725|GO:0002695|GO:0008285|GO:0050790|GO:0043086|GO:0010035|GO:0044249|GO:0043487|GO:0010033|GO:0031324|GO:0031323|GO:0071774|GO:0032616|GO:0051249|GO:0032714|GO:0010468|GO:0034645|GO:0032943|GO:0033993|GO:0034097|GO:0031410|GO:0010629|GO:0050727|GO:0002237|GO:0051252|GO:0034109|GO:0032633|GO:0016023|GO:0032673|GO:0005791|GO:0006954|GO:0051250|GO:0022408|GO:0022407|GO:0034021|GO:0032634|GO:0007159|GO:0010193|GO:0070848|GO:0031988|GO:0070664|GO:0055102|GO:0032674|GO:0032689|GO:0042110|GO:0014070|GO:0000302|GO:0032609|GO:0010467|GO:0046651|GO:0009059|GO:0016070|GO:0032496|GO:0005634|GO:0032713|GO:0048545|GO:0043488|GO:0032649|GO:0032696|GO:1903038|GO:0042098|GO:0050863|GO:0045892|GO:0032774|GO:0050868|GO:2001141|GO:0010608|GO:1902679|GO:0070486|GO:0004859|GO:0034111|GO:0032945|GO:0031960|GO:0050672|GO:0006351|GO:0006355|GO:0051384|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0019834|GO:0042130|GO:0042129|GO:0000122|GO:0071593 developmental process|reproduction|immune system process|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|cellular metabolic process|response to other organism|cell adhesion|membrane-bounded organelle|response to biotic stimulus|response to external stimulus|biosynthetic process|extracellular space|enzyme regulator activity|intracellular|regulation of immune system process|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|negative regulation of cytokine production|regulation of cell proliferation|single organismal cell-cell adhesion|enzyme inhibitor activity|cellular aromatic compound metabolic process|leukocyte proliferation|organic cyclic compound metabolic process|multicellular organism development|response to xenobiotic stimulus|T cell aggregation|cellular nitrogen compound metabolic process|defense response|regulation of cell adhesion|vesicle|heterocycle metabolic process|embryo implantation|regulation of cytokine production|cell-cell adhesion|secretory granule|intracellular membrane-bounded organelle|polychlorinated biphenyl binding|cytoplasm|cytokine production|response to wounding|nuclear envelope|cell activation|negative regulation of biosynthetic process|response to oxidative stress|response to drug|nucleobase-containing compound metabolic process|response to bacterium|negative regulation of cell adhesion|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|female pregnancy|signal transduction|endoplasmic reticulum|extracellular exosome|response to hormone|negative regulation of leukocyte activation|negative regulation of cell proliferation|regulation of catalytic activity|negative regulation of catalytic activity|response to inorganic substance|cellular biosynthetic process|regulation of RNA stability|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|response to fibroblast growth factor|interleukin-13 production|regulation of lymphocyte activation|negative regulation of interleukin-5 production|regulation of gene expression|cellular macromolecule biosynthetic process|mononuclear cell proliferation|response to lipid|response to cytokine|cytoplasmic vesicle|negative regulation of gene expression|regulation of inflammatory response|response to molecule of bacterial origin|regulation of RNA metabolic process|homotypic cell-cell adhesion|interleukin-4 production|cytoplasmic, membrane-bounded vesicle|regulation of interleukin-4 production|rough endoplasmic reticulum|inflammatory response|negative regulation of lymphocyte activation|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|response to silicon dioxide|interleukin-5 production|leukocyte cell-cell adhesion|response to ozone|response to growth factor|membrane-bounded vesicle|negative regulation of leukocyte proliferation|lipase inhibitor activity|regulation of interleukin-5 production|negative regulation of interferon-gamma production|T cell activation|response to organic cyclic compound|response to reactive oxygen species|interferon-gamma production|gene expression|lymphocyte proliferation|macromolecule biosynthetic process|RNA metabolic process|response to lipopolysaccharide|nucleus|negative regulation of interleukin-4 production|response to steroid hormone|regulation of mRNA stability|regulation of interferon-gamma production|negative regulation of interleukin-13 production|negative regulation of leukocyte cell-cell adhesion|T cell proliferation|regulation of T cell activation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|negative regulation of T cell activation|regulation of RNA biosynthetic process|posttranscriptional regulation of gene expression|negative regulation of RNA biosynthetic process|leukocyte aggregation|phospholipase inhibitor activity|negative regulation of homotypic cell-cell adhesion|negative regulation of mononuclear cell proliferation|response to corticosteroid|negative regulation of lymphocyte proliferation|transcription, DNA-templated|regulation of transcription, DNA-templated|response to glucocorticoid|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|phospholipase A2 inhibitor activity|negative regulation of T cell proliferation|regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|lymphocyte aggregation - - - - 11:62405103-62423195 6 3 9 1 1 1 0.729211989156341 0.331430121812849 0.986201192085142 0.108846724228199 0.0997649958494028 0.113893033295048 0.682281101018111 0.10750158445755 2.6660083308901 0.00305400348514744 0.0153861894334722 UP ENSG00000180938 ZNF572 zinc finger protein 572 [Source:HGNC Symbol;Acc:HGNC:26758] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 8:124973298-124979389 24 34 33 69 58 67 0.518373060062552 0.667410158988813 0.642638882966313 1.33530336926457 1.02785165379209 1.35624704559094 0.609474034005893 1.2398006895492 -1.02447154871377 0.00305555150439545 0.0153861894334722 DOWN ENSG00000278600 RP11-81A1.6 - - - - - - - 15:79920195-79922455 27 22 49 62 68 94 0.844717200806636 0.625528812799438 1.38214260296699 1.73794101070308 1.74551700867621 2.7561414196196 0.950796205524355 2.0798664796663 -1.12928286439915 0.00306413650059757 0.0154208919569858 DOWN ENSG00000121318 TAS2R10 taste 2 receptor member 10 [Source:HGNC Symbol;Acc:HGNC:14918] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0051606|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0050877|GO:0004888|GO:0050906|GO:0007154|GO:0009593|GO:0007165|GO:0016021|GO:0007186|GO:0050907|GO:0007600|GO:0004930|GO:0008527|GO:0050912|GO:0007606|GO:0050909|GO:0033038|GO:0001580|GO:0050913 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|detection of stimulus|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|neurological system process|transmembrane signaling receptor activity|detection of stimulus involved in sensory perception|cell communication|detection of chemical stimulus|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|detection of chemical stimulus involved in sensory perception|sensory perception|G-protein coupled receptor activity|taste receptor activity|detection of chemical stimulus involved in sensory perception of taste|sensory perception of chemical stimulus|sensory perception of taste|bitter taste receptor activity|detection of chemical stimulus involved in sensory perception of bitter taste|sensory perception of bitter taste - - - - 12:10825317-10826358 1 3 0 7 4 15 0.0679142931119135 0.185117400091246 0 0.425752312036296 0.222779911362326 0.954344735284621 0.0843438977343865 0.534292319561081 -2.66327367992593 0.0030704944627659 0.015445078633768 DOWN ENSG00000281530 DGCR12 DiGeorge syndrome critical region gene 12 (non-protein coding) [Source:HGNC Symbol;Acc:HGNC:17225] - - - - - - 22:19061041-19061843 0 0 2 9 6 3 0 0 0.158849444574629 0.71033077752863 0.43363013880363 0.24764288435013 0.0529498148582097 0.463867933560797 -3.13101657358181 0.00309585267528161 0.0155621461134631 DOWN ENSG00000163072 NOSTRIN nitric oxide synthase trafficking [Source:HGNC Symbol;Acc:HGNC:20203] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0071944|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0031090|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0003676|GO:0034641|GO:0044281|GO:2001057|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0012506|GO:0072593|GO:0030666|GO:0009890|GO:0006139|GO:0007154|GO:0007165|GO:0050790|GO:0044249|GO:0031324|GO:0031323|GO:0016192|GO:0003677|GO:0010468|GO:0034645|GO:0031410|GO:0010629|GO:0051252|GO:0016023|GO:0046209|GO:0031988|GO:0051341|GO:0030659|GO:0010467|GO:0009059|GO:0016070|GO:0005856|GO:0005634|GO:0030139|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006897|GO:0006351|GO:0006355|GO:1903507|GO:1903506|GO:0050999 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|cell periphery|biosynthetic process|intracellular|protein binding|plasma membrane|organelle membrane|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|small molecule metabolic process|reactive nitrogen species metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|reactive oxygen species metabolic process|endocytic vesicle membrane|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|signal transduction|regulation of catalytic activity|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|vesicle-mediated transport|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|cytoplasmic vesicle|negative regulation of gene expression|regulation of RNA metabolic process|cytoplasmic, membrane-bounded vesicle|nitric oxide metabolic process|membrane-bounded vesicle|regulation of oxidoreductase activity|cytoplasmic vesicle membrane|gene expression|macromolecule biosynthetic process|RNA metabolic process|cytoskeleton|nucleus|endocytic vesicle|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|endocytosis|transcription, DNA-templated|regulation of transcription, DNA-templated|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|regulation of nitric-oxide synthase activity - - - - 2:168786539-168865514 1 2 4 7 11 11 0.0089748501487145 0.0163062275406644 0.0323541164219219 0.0562630195487407 0.0809644764341421 0.0924811307425873 0.0192117313704336 0.0765695422418234 -1.99478309119421 0.00312554108620798 0.0157008082765696 DOWN ENSG00000231062 AC103563.9 - - - - - - - 2:95051395-95053176 7 5 8 16 21 22 0.829427254793307 0.538470577978588 0.854647262937534 1.69854191540588 2.04154888966667 2.44304513996818 0.740848365236476 2.06104531501358 -1.47612603384079 0.00312608957174003 0.0157009216141869 DOWN ENSG00000198947 DMD dystrophin [Source:HGNC Symbol;Acc:HGNC:2928] GO:0032502|GO:0032991|GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0005200|GO:0051716|GO:0042995|GO:0009892|GO:0030055|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0071704|GO:0043167|GO:0009628|GO:0009986|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009605|GO:0023057|GO:0009058|GO:0050793|GO:0008307|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0097060|GO:0048646|GO:0019222|GO:0030017|GO:0060341|GO:0030018|GO:0051282|GO:0042391|GO:0045595|GO:0006725|GO:0051640|GO:0009888|GO:0048468|GO:0006810|GO:0051130|GO:0009612|GO:1901360|GO:0098797|GO:0007275|GO:0048513|GO:0034641|GO:0043062|GO:0030155|GO:0043270|GO:0046483|GO:0051128|GO:0045211|GO:0090287|GO:0022607|GO:0061061|GO:0045597|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0003012|GO:0006928|GO:0042592|GO:0016203|GO:0043005|GO:0031589|GO:0009966|GO:0042383|GO:0019725|GO:0031674|GO:0010646|GO:0006139|GO:0008104|GO:0007154|GO:0055085|GO:0007165|GO:0009968|GO:0016328|GO:0051649|GO:0045785|GO:0008092|GO:2000021|GO:0044306|GO:0021675|GO:0048532|GO:0021602|GO:0030030|GO:0031253|GO:0043034|GO:0051238|GO:0001948|GO:0002027|GO:0048869|GO:0030029|GO:0044249|GO:0010469|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0032411|GO:0003013|GO:0006996|GO:0000165|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0031344|GO:0010468|GO:0006936|GO:0034645|GO:0006518|GO:0046872|GO:0043412|GO:0021782|GO:0010720|GO:0042692|GO:0002064|GO:0048878|GO:0051252|GO:0017022|GO:0030048|GO:0032386|GO:0003779|GO:0050998|GO:0031346|GO:0090257|GO:0001508|GO:0016013|GO:0051208|GO:0034767|GO:0046716|GO:0016010|GO:0036211|GO:0044782|GO:0032269|GO:0060537|GO:0007160|GO:0046907|GO:0060856|GO:0006811|GO:0051209|GO:0055082|GO:0051279|GO:0043292|GO:0050769|GO:0030031|GO:0035994|GO:0010810|GO:0017166|GO:0070848|GO:0034765|GO:0051647|GO:0030175|GO:0006461|GO:0055001|GO:0043269|GO:0034613|GO:0031527|GO:0070925|GO:0060429|GO:0006796|GO:0043603|GO:0042384|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0010765|GO:0032990|GO:0007399|GO:0071310|GO:0032414|GO:1902532|GO:0030198|GO:0002162|GO:0051246|GO:0009059|GO:0010522|GO:0010811|GO:0030154|GO:0048858|GO:0045121|GO:0007517|GO:1902531|GO:0016070|GO:0008015|GO:0005856|GO:0050881|GO:0005634|GO:0060314|GO:0022898|GO:0051960|GO:0007422|GO:0034220|GO:0021545|GO:0043112|GO:0048666|GO:0006941|GO:0030182|GO:0060271|GO:0008016|GO:0055002|GO:0003158|GO:0015629|GO:0060538|GO:0098655|GO:0043043|GO:0010975|GO:0070252|GO:0001885|GO:0086001|GO:0030016|GO:0010001|GO:0034622|GO:0030855|GO:0006937|GO:0043408|GO:0032774|GO:0008065|GO:0003009|GO:0060047|GO:0006812|GO:2001141|GO:0010880|GO:0043623|GO:0071363|GO:0060857|GO:0016310|GO:0014808|GO:0060402|GO:0070371|GO:0016482|GO:0032412|GO:0001952|GO:0021553|GO:0001954|GO:1902307|GO:0051146|GO:0030049|GO:0046914|GO:0050801|GO:0043409|GO:2000651|GO:0014706|GO:0022008|GO:0006464|GO:0045213|GO:0019932|GO:0050767|GO:0050848|GO:0010976|GO:0044458|GO:0006351|GO:0006355|GO:0006873|GO:0021629|GO:0090279|GO:0070296|GO:0045666|GO:1903169|GO:0014819|GO:0045446|GO:0010881|GO:0014722|GO:0006468|GO:0033275|GO:0048699|GO:0007519|GO:1903506|GO:0006942|GO:0060048|GO:0042325|GO:0001932|GO:0018193|GO:0042326|GO:0048747|GO:0014902|GO:0042063|GO:0055117|GO:0002028|GO:1901019|GO:1902305|GO:0030001|GO:0019722|GO:0014904|GO:2000649|GO:0051924|GO:1902083|GO:0001933|GO:2001257|GO:0070372|GO:0014809|GO:0070373|GO:0008270|GO:0045664|GO:0030003|GO:0015672|GO:0018119|GO:0033137|GO:0035725|GO:1901385|GO:0070588|GO:0010882|GO:0006814|GO:0055065|GO:0097553|GO:0006875|GO:0018105|GO:0033135|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 developmental process|macromolecular complex|synapse|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|structural constituent of cytoskeleton|cellular response to stimulus|cell projection|negative regulation of metabolic process|cell-substrate junction|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|organic substance metabolic process|ion binding|response to abiotic stimulus|cell surface|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|response to external stimulus|negative regulation of signaling|biosynthetic process|regulation of developmental process|structural constituent of muscle|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|synaptic membrane|anatomical structure formation involved in morphogenesis|regulation of metabolic process|sarcomere|regulation of cellular localization|Z disc|regulation of sequestering of calcium ion|regulation of membrane potential|regulation of cell differentiation|cellular aromatic compound metabolic process|organelle localization|tissue development|cell development|transport|positive regulation of cellular component organization|response to mechanical stimulus|organic cyclic compound metabolic process|plasma membrane protein complex|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|extracellular structure organization|regulation of cell adhesion|positive regulation of ion transport|heterocycle metabolic process|regulation of cellular component organization|postsynaptic membrane|regulation of cellular response to growth factor stimulus|cellular component assembly|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|muscle system process|movement of cell or subcellular component|homeostatic process|muscle attachment|neuron projection|cell-substrate adhesion|regulation of signal transduction|sarcolemma|cellular homeostasis|I band|regulation of cell communication|nucleobase-containing compound metabolic process|protein localization|cell communication|transmembrane transport|signal transduction|negative regulation of signal transduction|lateral plasma membrane|establishment of localization in cell|positive regulation of cell adhesion|cytoskeletal protein binding|regulation of ion homeostasis|neuron projection terminus|nerve development|anatomical structure arrangement|cranial nerve morphogenesis|cell projection organization|cell projection membrane|costamere|sequestering of metal ion|glycoprotein binding|regulation of heart rate|cellular developmental process|actin filament-based process|cellular biosynthetic process|regulation of receptor activity|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|positive regulation of transporter activity|circulatory system process|organelle organization|MAPK cascade|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|regulation of cell projection organization|regulation of gene expression|muscle contraction|cellular macromolecule biosynthetic process|peptide metabolic process|metal ion binding|macromolecule modification|glial cell development|positive regulation of cell development|muscle cell differentiation|epithelial cell development|chemical homeostasis|regulation of RNA metabolic process|myosin binding|actin filament-based movement|regulation of intracellular transport|actin binding|nitric-oxide synthase binding|positive regulation of cell projection organization|regulation of muscle system process|action potential|syntrophin complex|sequestering of calcium ion|positive regulation of ion transmembrane transport|muscle cell cellular homeostasis|dystrophin-associated glycoprotein complex|protein modification process|cilium organization|negative regulation of cellular protein metabolic process|muscle tissue development|cell-matrix adhesion|intracellular transport|establishment of blood-brain barrier|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|regulation of release of sequestered calcium ion into cytosol|contractile fiber|positive regulation of neurogenesis|cell projection assembly|response to muscle stretch|regulation of cell-substrate adhesion|vinculin binding|response to growth factor|regulation of ion transmembrane transport|nucleus localization|filopodium|protein complex assembly|muscle cell development|regulation of ion transport|cellular protein localization|filopodium membrane|organelle assembly|epithelium development|phosphate-containing compound metabolic process|cellular amide metabolic process|cilium assembly|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|positive regulation of sodium ion transport|cell part morphogenesis|nervous system development|cellular response to organic substance|positive regulation of ion transmembrane transporter activity|negative regulation of intracellular signal transduction|extracellular matrix organization|dystroglycan binding|regulation of protein metabolic process|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|positive regulation of cell-substrate adhesion|cell differentiation|cell projection morphogenesis|membrane raft|muscle organ development|regulation of intracellular signal transduction|RNA metabolic process|blood circulation|cytoskeleton|musculoskeletal movement|nucleus|regulation of ryanodine-sensitive calcium-release channel activity|regulation of transmembrane transporter activity|regulation of nervous system development|peripheral nervous system development|ion transmembrane transport|cranial nerve development|receptor metabolic process|neuron development|striated muscle contraction|neuron differentiation|cilium morphogenesis|regulation of heart contraction|striated muscle cell development|endothelium development|actin cytoskeleton|skeletal muscle organ development|cation transmembrane transport|peptide biosynthetic process|regulation of neuron projection development|actin-mediated cell contraction|endothelial cell development|cardiac muscle cell action potential|myofibril|glial cell differentiation|cellular macromolecular complex assembly|epithelial cell differentiation|regulation of muscle contraction|regulation of MAPK cascade|RNA biosynthetic process|establishment of blood-nerve barrier|skeletal muscle contraction|heart contraction|cation transport|regulation of RNA biosynthetic process|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|cellular protein complex assembly|cellular response to growth factor stimulus|establishment of glial blood-brain barrier|phosphorylation|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|calcium ion transport into cytosol|ERK1 and ERK2 cascade|cytosolic transport|regulation of ion transmembrane transporter activity|regulation of cell-matrix adhesion|olfactory nerve development|positive regulation of cell-matrix adhesion|positive regulation of sodium ion transmembrane transport|striated muscle cell differentiation|muscle filament sliding|transition metal ion binding|ion homeostasis|negative regulation of MAPK cascade|positive regulation of sodium ion transmembrane transporter activity|striated muscle tissue development|neurogenesis|cellular protein modification process|neurotransmitter receptor metabolic process|second-messenger-mediated signaling|regulation of neurogenesis|regulation of calcium-mediated signaling|positive regulation of neuron projection development|motile cilium assembly|transcription, DNA-templated|regulation of transcription, DNA-templated|cellular ion homeostasis|olfactory nerve structural organization|regulation of calcium ion import|sarcoplasmic reticulum calcium ion transport|positive regulation of neuron differentiation|regulation of calcium ion transmembrane transport|regulation of skeletal muscle contraction|endothelial cell differentiation|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of skeletal muscle contraction by calcium ion signaling|protein phosphorylation|actin-myosin filament sliding|generation of neurons|skeletal muscle tissue development|regulation of nucleic acid-templated transcription|regulation of striated muscle contraction|cardiac muscle contraction|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|negative regulation of phosphorylation|muscle fiber development|myotube differentiation|gliogenesis|regulation of cardiac muscle contraction|regulation of sodium ion transport|regulation of calcium ion transmembrane transporter activity|regulation of sodium ion transmembrane transport|metal ion transport|calcium-mediated signaling|myotube cell development|regulation of sodium ion transmembrane transporter activity|regulation of calcium ion transport|negative regulation of peptidyl-cysteine S-nitrosylation|negative regulation of protein phosphorylation|regulation of cation channel activity|regulation of ERK1 and ERK2 cascade|regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion|negative regulation of ERK1 and ERK2 cascade|zinc ion binding|regulation of neuron differentiation|cellular cation homeostasis|monovalent inorganic cation transport|peptidyl-cysteine S-nitrosylation|negative regulation of peptidyl-serine phosphorylation|sodium ion transmembrane transport|regulation of voltage-gated calcium channel activity|calcium ion transmembrane transport|regulation of cardiac muscle contraction by calcium ion signaling|sodium ion transport|metal ion homeostasis|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|peptidyl-serine phosphorylation|regulation of peptidyl-serine phosphorylation|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K10366 dystrophin[-] hsa05414|hsa05410|hsa05412|hsa05416 Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)|Viral myocarditis - Homo sapiens (human) X:31097677-33339441 1 0 0 3 5 6 0.00238955574616289 0 0 0.00641939890982548 0.00979908476190767 0.0134318753677768 0.000796518582054297 0.00988345301316998 -3.6332352447793 0.00312667777898866 0.0157012343841762 DOWN ENSG00000163803 PLB1 phospholipase B1 [Source:HGNC Symbol;Acc:HGNC:30041] GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0003824|GO:0051716|GO:0051606|GO:0050794|GO:0006807|GO:0051050|GO:0044702|GO:0071704|GO:0009056|GO:0009628|GO:0019953|GO:0044237|GO:0051641|GO:0045177|GO:0071944|GO:0009605|GO:0016787|GO:0009058|GO:0031224|GO:0005886|GO:0007340|GO:0060341|GO:0044255|GO:0009314|GO:0006810|GO:0016324|GO:0060627|GO:0034641|GO:0016788|GO:0044281|GO:0032940|GO:0060046|GO:0019637|GO:0009582|GO:0007154|GO:0006629|GO:0007165|GO:0009566|GO:0051047|GO:0016021|GO:0044249|GO:2000344|GO:0016192|GO:0008654|GO:0046486|GO:0009583|GO:0016042|GO:0006720|GO:0006066|GO:0009308|GO:0045921|GO:0006887|GO:0046470|GO:0007338|GO:0007602|GO:0017157|GO:0051046|GO:0016298|GO:0006796|GO:0008610|GO:0046903|GO:0052689|GO:0009416|GO:0006644|GO:0004620|GO:0004622|GO:0045055|GO:0046474|GO:0004623|GO:1903307|GO:0009584|GO:0006576|GO:1903305|GO:0036151|GO:0007603|GO:0006650|GO:0017156|GO:0017158|GO:0045956|GO:0016101|GO:0001523 reproduction|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|catalytic activity|cellular response to stimulus|detection of stimulus|regulation of cellular process|nitrogen compound metabolic process|positive regulation of transport|single organism reproductive process|organic substance metabolic process|catabolic process|response to abiotic stimulus|sexual reproduction|cellular metabolic process|cellular localization|apical part of cell|cell periphery|response to external stimulus|hydrolase activity|biosynthetic process|intrinsic component of membrane|plasma membrane|acrosome reaction|regulation of cellular localization|cellular lipid metabolic process|response to radiation|transport|apical plasma membrane|regulation of vesicle-mediated transport|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|secretion by cell|regulation of acrosome reaction|organophosphate metabolic process|detection of abiotic stimulus|cell communication|lipid metabolic process|signal transduction|fertilization|positive regulation of secretion|integral component of membrane|cellular biosynthetic process|positive regulation of acrosome reaction|vesicle-mediated transport|phospholipid biosynthetic process|glycerolipid metabolic process|detection of light stimulus|lipid catabolic process|isoprenoid metabolic process|alcohol metabolic process|amine metabolic process|positive regulation of exocytosis|exocytosis|phosphatidylcholine metabolic process|single fertilization|phototransduction|regulation of exocytosis|regulation of secretion|lipase activity|phosphate-containing compound metabolic process|lipid biosynthetic process|secretion|carboxylic ester hydrolase activity|response to light stimulus|phospholipid metabolic process|phospholipase activity|lysophospholipase activity|regulated exocytosis|glycerophospholipid biosynthetic process|phospholipase A2 activity|positive regulation of regulated secretory pathway|detection of visible light|cellular biogenic amine metabolic process|regulation of regulated secretory pathway|phosphatidylcholine acyl-chain remodeling|phototransduction, visible light|glycerophospholipid metabolic process|calcium ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|positive regulation of calcium ion-dependent exocytosis|diterpenoid metabolic process|retinoid metabolic process K14621 phospholipase B1, membrane-associated[3.1.1.5] hsa01100|hsa00564|hsa00590|hsa00565|hsa00591|hsa00592|hsa04977 Metabolic pathways - Homo sapiens (human)|Glycerophospholipid metabolism - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human)|Ether lipid metabolism - Homo sapiens (human)|Linoleic acid metabolism - Homo sapiens (human)|alpha-Linolenic acid metabolism - Homo sapiens (human)|Vitamin digestion and absorption - Homo sapiens (human) 2:28457145-28643788 6 9 27 31 47 39 0.0386945092714251 0.0527549364851837 0.156999820362363 0.179131131791923 0.248706169719721 0.235730912972558 0.0828164220396573 0.221189404828067 -1.41729350116112 0.00313280513010336 0.0157293582835698 DOWN ENSG00000251537 RP11-385D13.1 - GO:0005623|GO:0005488|GO:0043167|GO:0005622|GO:0005515|GO:0043169|GO:0046872|GO:0046914|GO:0008270 cell|binding|ion binding|intracellular|protein binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 17:15571491-15651653 67 375 194 565 435 664 0.859517705993507 4.37210168739734 2.24385352658573 6.49419578091019 4.57863206122486 7.98317650296267 2.49182430665886 6.35200144836591 -1.35000889091449 0.00315191447946112 0.0158146646840054 DOWN ENSG00000258725 PRC1-AS1 PRC1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:48587] - - - - - - 15:90966345-90988624 12 10 18 3 3 8 0.403071707657587 0.30525784462996 0.545111555527466 0.0902708920771517 0.0826835524236107 0.251831186976328 0.417813702605004 0.141595210492363 1.56108734118126 0.00316636378949425 0.0158791574956428 UP ENSG00000225173 XXbac-BPG308K3.5 - - - - - - - 6:28837869-28839006 16 7 20 4 1 8 1.59633747266508 0.63475534444479 1.79909878693127 0.357578858148574 0.0818945382007792 0.748034527182153 1.34339720134705 0.395835974510502 1.76291128951337 0.00316926421904381 0.0158910335900796 UP ENSG00000078399 HOXA9 homeobox A9 [Source:HGNC Symbol;Acc:HGNC:5109] GO:0032502|GO:0032991|GO:0000003|GO:0002376|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0002683|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0003006|GO:0009653|GO:0043227|GO:0032504|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0045137|GO:1903706|GO:0045595|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0060065|GO:0034641|GO:0046483|GO:0043231|GO:0048608|GO:0019899|GO:0005737|GO:0007389|GO:0005667|GO:0001775|GO:0048598|GO:0007548|GO:0006139|GO:0008406|GO:0007276|GO:0009566|GO:0048869|GO:0044249|GO:0031323|GO:0048732|GO:0003677|GO:0030879|GO:0010468|GO:0034645|GO:0008584|GO:0048232|GO:0046661|GO:0061458|GO:0030097|GO:0051252|GO:0009790|GO:0007338|GO:0003002|GO:0035108|GO:0010467|GO:0009059|GO:0030154|GO:0001501|GO:0060173|GO:0042118|GO:0016070|GO:0005634|GO:0045638|GO:0045637|GO:0046546|GO:0007283|GO:0048706|GO:0009792|GO:0032774|GO:0043565|GO:2001141|GO:0009952|GO:0035136|GO:0030099|GO:0060216|GO:0009954|GO:0030326|GO:0006351|GO:0006355|GO:0035115|GO:1903506|GO:0043009 developmental process|macromolecular complex|reproduction|immune system process|cell|cellular process|reproductive process|metabolic process|binding|negative regulation of immune system process|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|anatomical structure morphogenesis|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|development of primary sexual characteristics|regulation of hemopoiesis|regulation of cell differentiation|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|uterus development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|reproductive structure development|enzyme binding|cytoplasm|pattern specification process|transcription factor complex|cell activation|embryonic morphogenesis|sex differentiation|nucleobase-containing compound metabolic process|gonad development|gamete generation|fertilization|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|gland development|DNA binding|mammary gland development|regulation of gene expression|cellular macromolecule biosynthetic process|male gonad development|male gamete generation|male sex differentiation|reproductive system development|hemopoiesis|regulation of RNA metabolic process|embryo development|single fertilization|regionalization|limb morphogenesis|gene expression|macromolecule biosynthetic process|cell differentiation|skeletal system development|limb development|endothelial cell activation|RNA metabolic process|nucleus|negative regulation of myeloid cell differentiation|regulation of myeloid cell differentiation|development of primary male sexual characteristics|spermatogenesis|embryonic skeletal system development|embryo development ending in birth or egg hatching|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|anterior/posterior pattern specification|forelimb morphogenesis|myeloid cell differentiation|definitive hemopoiesis|proximal/distal pattern formation|embryonic limb morphogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|embryonic forelimb morphogenesis|regulation of nucleic acid-templated transcription|chordate embryonic development K09294 homeobox protein HoxA/B/C/D9[-] hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) 7:27162435-27175180 109 71 59 37 58 20 1.29781565335279 0.768293026808922 0.633362219369717 0.394713915020168 0.566607333137369 0.223170500093446 0.899823633177143 0.394830582750328 1.18840851643271 0.00317584016225968 0.0159159866046837 UP ENSG00000214280 RP11-553K23.2 - - - - - - - 3:139582928-139583593 0 1 1 4 5 8 0 0.0965731632686777 0.0957127294592259 0.380665781422431 0.435735578414258 0.796331050708929 0.0640952975759679 0.537577470181873 -3.06818225529339 0.00318497593130891 0.015956414071706 DOWN ENSG00000002726 AOC1 amine oxidase, copper containing 1 [Source:HGNC Symbol;Acc:HGNC:80] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0004872|GO:0044877|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0008144|GO:0044237|GO:0005911|GO:0043227|GO:0048037|GO:0071944|GO:0009605|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0042802|GO:0048038|GO:0008201|GO:0009991|GO:0009410|GO:0043168|GO:0044281|GO:0031982|GO:0033554|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0031668|GO:0032403|GO:0046983|GO:0042493|GO:0007154|GO:0070062|GO:0006805|GO:0010035|GO:0005539|GO:0010033|GO:0043296|GO:0042594|GO:0016638|GO:0055114|GO:0009636|GO:0016641|GO:0046872|GO:0034776|GO:0009308|GO:0071417|GO:0010038|GO:0071466|GO:0046688|GO:0009267|GO:0046677|GO:0014070|GO:0060359|GO:0071241|GO:0071310|GO:0071503|GO:0005923|GO:0031669|GO:0031667|GO:0042803|GO:0008131|GO:0071242|GO:0052599|GO:0005777|GO:0097185|GO:0071504|GO:0005509|GO:0071407|GO:0052600|GO:0071420|GO:0046914|GO:0071280|GO:0052597|GO:0035874|GO:0052598|GO:0071248|GO:0005507|GO:0008270 cell|membrane|cellular process|extracellular region|metabolic process|cell junction|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|receptor activity|macromolecular complex binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|drug binding|cellular metabolic process|cell-cell junction|membrane-bounded organelle|cofactor binding|cell periphery|response to external stimulus|extracellular space|intracellular|protein binding|plasma membrane|identical protein binding|quinone binding|heparin binding|response to extracellular stimulus|response to xenobiotic stimulus|anion binding|small molecule metabolic process|vesicle|cellular response to stress|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|cellular response to extracellular stimulus|protein complex binding|protein dimerization activity|response to drug|cell communication|extracellular exosome|xenobiotic metabolic process|response to inorganic substance|glycosaminoglycan binding|response to organic substance|apical junction complex|response to starvation|oxidoreductase activity, acting on the CH-NH2 group of donors|oxidation-reduction process|response to toxic substance|oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor|metal ion binding|response to histamine|amine metabolic process|cellular response to organonitrogen compound|response to metal ion|cellular response to xenobiotic stimulus|response to copper ion|cellular response to starvation|response to antibiotic|response to organic cyclic compound|response to ammonium ion|cellular response to inorganic substance|cellular response to organic substance|response to heparin|bicellular tight junction|cellular response to nutrient levels|response to nutrient levels|protein homodimerization activity|primary amine oxidase activity|cellular response to ammonium ion|methylputrescine oxidase activity|peroxisome|cellular response to azide|cellular response to heparin|calcium ion binding|cellular response to organic cyclic compound|propane-1,3-diamine oxidase activity|cellular response to histamine|transition metal ion binding|cellular response to copper ion|diamine oxidase activity|cellular response to copper ion starvation|histamine oxidase activity|cellular response to metal ion|copper ion binding|zinc ion binding K11182 diamine oxidase[1.4.3.22] hsa01100|hsa00330|hsa00380|hsa00340 Metabolic pathways - Homo sapiens (human)|Arginine and proline metabolism - Homo sapiens (human)|Tryptophan metabolism - Homo sapiens (human)|Histidine metabolism - Homo sapiens (human) 7:150824627-150861504 4 6 8 12 20 26 0.0312013952131297 0.0425368121387756 0.0562664772798531 0.0838740881431425 0.128004130960151 0.190079502654596 0.0433348948772528 0.13398590725263 -1.62848015479875 0.00319038244430619 0.0159754574794225 DOWN ENSG00000249267 LINC00939 long intergenic non-protein coding RNA 939 [Source:HGNC Symbol;Acc:HGNC:48631] - - - - - - 12:125958688-125983374 1 1 0 4 5 8 0.00776972918561856 0.00706167399395469 0 0.0278352448866204 0.0318620877496592 0.0582297408621153 0.00494380105985775 0.039309024499465 -2.99116796698923 0.00319777154263053 0.0160044042973498 DOWN ENSG00000271851 RP11-565F19.2 - - - - - - - 17:9553323-9555696 6 6 7 22 23 13 0.178770588748522 0.16247843827903 0.188042539932656 0.587327143697691 0.562288551369323 0.363039479111684 0.176430522320069 0.504218391392899 -1.51494857411701 0.00320003363012738 0.0160103576326165 DOWN ENSG00000213901 SLC23A3 solute carrier family 23 member 3 [Source:HGNC Symbol;Acc:HGNC:20601] GO:0005215|GO:0016020|GO:0009987|GO:0031224|GO:0006810|GO:0055085|GO:0016021 transporter activity|membrane|cellular process|intrinsic component of membrane|transport|transmembrane transport|integral component of membrane - - - - 2:219161465-219170095 13 8 17 29 28 43 0.114946181100074 0.0642873020790695 0.135524188720908 0.229751583311523 0.203134114521834 0.356329954374236 0.104919223966684 0.263071884069198 -1.32617802614979 0.00321637601099396 0.0160813413887479 DOWN ENSG00000174004 NRROS negative regulator of reactive oxygen species [Source:HGNC Symbol;Acc:HGNC:24613] GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0043229|GO:0006950|GO:0042175|GO:0006955|GO:0044237|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0045087|GO:0006952|GO:0043231|GO:0005737|GO:0072593|GO:0005783|GO:0016021|GO:0006954|GO:0006801 immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|binding|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|immune response|cellular metabolic process|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|innate immune response|defense response|intracellular membrane-bounded organelle|cytoplasm|reactive oxygen species metabolic process|endoplasmic reticulum|integral component of membrane|inflammatory response|superoxide metabolic process - - - - 3:196639686-196662004 41 56 31 10 31 18 0.920711661348258 1.14288537029457 0.627646424673413 0.201209055894713 0.571176024628188 0.378820460412612 0.897081152105414 0.383735180311838 1.22512746539539 0.0032248630256842 0.0161210751454749 UP ENSG00000280138 RP11-463O12.5 - - - - - - - 12:122870059-122888720 25 124 185 46 35 44 0.0947614652838642 0.427158153349299 0.632228016922097 0.15622071500859 0.108849059330101 0.156302935396614 0.38471587851842 0.140457569911768 1.45365899563471 0.00324091112068942 0.0161904552538591 UP ENSG00000164849 GPR146 G protein-coupled receptor 146 [Source:HGNC Symbol;Acc:HGNC:21718] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0004930 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|G-protein coupled receptor activity - - - - 7:1044576-1059261 39 62 85 19 24 46 0.439284768535316 0.634683555557692 0.8632113931268 0.191752251659847 0.221805135117058 0.485588673746344 0.645726572406603 0.29971535350775 1.1073304062696 0.00324786970000236 0.0162197895657194 UP ENSG00000226777 KIAA0125 KIAA0125 [Source:HGNC Symbol;Acc:HGNC:19955] - - - - - - 14:105917979-105932642 0 0 1 1 4 15 0 0 0.00573398199332954 0.00569837127829559 0.0208812330340508 0.0894510402236732 0.00191132733110985 0.0386768815120065 -4.33882469766354 0.00325216285015994 0.0162376555419426 DOWN ENSG00000104490 NCALD neurocalcin delta [Source:HGNC Symbol;Acc:HGNC:7655] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0043167|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0031090|GO:0006810|GO:0030660|GO:0031982|GO:0030276|GO:0030117|GO:0043231|GO:0043169|GO:0030133|GO:0005737|GO:0007267|GO:0012506|GO:0030658|GO:0007154|GO:0007165|GO:0070062|GO:0008092|GO:0008217|GO:0003013|GO:0005794|GO:0016192|GO:0015631|GO:0005829|GO:0005798|GO:0046872|GO:0031410|GO:0030130|GO:0003779|GO:0016023|GO:0030665|GO:0012510|GO:0031988|GO:0030118|GO:0035556|GO:0030659|GO:0030140|GO:0000139|GO:0030120|GO:0008015|GO:0003073|GO:0030125|GO:0005509|GO:0043014|GO:0030135|GO:0019932|GO:0030136|GO:0019722|GO:0007268 macromolecular complex|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|ion binding|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|organelle membrane|transport|Golgi-associated vesicle membrane|vesicle|clathrin binding|membrane coat|intracellular membrane-bounded organelle|cation binding|transport vesicle|cytoplasm|cell-cell signaling|vesicle membrane|transport vesicle membrane|cell communication|signal transduction|extracellular exosome|cytoskeletal protein binding|regulation of blood pressure|circulatory system process|Golgi apparatus|vesicle-mediated transport|tubulin binding|cytosol|Golgi-associated vesicle|metal ion binding|cytoplasmic vesicle|clathrin coat of trans-Golgi network vesicle|actin binding|cytoplasmic, membrane-bounded vesicle|clathrin-coated vesicle membrane|trans-Golgi network transport vesicle membrane|membrane-bounded vesicle|clathrin coat|intracellular signal transduction|cytoplasmic vesicle membrane|trans-Golgi network transport vesicle|Golgi membrane|vesicle coat|blood circulation|regulation of systemic arterial blood pressure|clathrin vesicle coat|calcium ion binding|alpha-tubulin binding|coated vesicle|second-messenger-mediated signaling|clathrin-coated vesicle|calcium-mediated signaling|synaptic transmission K19695 neurocalcin delta[-] hsa04740 Olfactory transduction - Homo sapiens (human) 8:101686543-102124907 0 2 0 6 4 7 0 0.00587715884984865 0 0.0173828731380449 0.0106109918014144 0.0212127226948132 0.00195905294994955 0.0164021958780908 -3.06566067467533 0.00326786251796802 0.0163005459668199 DOWN ENSG00000007402 CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 [Source:HGNC Symbol;Acc:HGNC:1400] GO:0032502|GO:0040007|GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0022857|GO:0050794|GO:0043167|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0045927|GO:0071944|GO:0040008|GO:0031224|GO:0050793|GO:0048589|GO:0005886|GO:0043234|GO:0048856|GO:0060341|GO:0050804|GO:0048468|GO:0006810|GO:0098797|GO:0015980|GO:0046620|GO:0044281|GO:0032940|GO:0035265|GO:0061061|GO:0043169|GO:0007267|GO:0032880|GO:0035264|GO:0045184|GO:0046883|GO:0048639|GO:0022891|GO:0010646|GO:0008104|GO:1902495|GO:0007154|GO:0055085|GO:0046622|GO:0048638|GO:0050808|GO:0040014|GO:0006091|GO:0010817|GO:0048869|GO:0016021|GO:0055114|GO:0046872|GO:0090276|GO:0007528|GO:0042692|GO:0051223|GO:0015031|GO:0070201|GO:0015267|GO:0042886|GO:0006811|GO:0015075|GO:0005891|GO:0060024|GO:0051046|GO:0009914|GO:0009306|GO:0034765|GO:0034702|GO:0055001|GO:0043269|GO:0006112|GO:0046903|GO:0030154|GO:0034220|GO:0050796|GO:0055002|GO:0002790|GO:0030073|GO:0098655|GO:0005216|GO:0034703|GO:0006812|GO:0050708|GO:0015833|GO:0051146|GO:0046879|GO:0008324|GO:0030072|GO:0005244|GO:0048747|GO:0034704|GO:0022890|GO:0030001|GO:0005261|GO:0007268|GO:0005262|GO:0070588|GO:0022843|GO:0046873|GO:0006816|GO:0015085|GO:0005245 developmental process|growth|macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|metabolic process|binding|transmembrane transporter activity|regulation of cellular process|ion binding|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|positive regulation of growth|cell periphery|regulation of growth|intrinsic component of membrane|regulation of developmental process|developmental growth|plasma membrane|protein complex|anatomical structure development|regulation of cellular localization|modulation of synaptic transmission|cell development|transport|plasma membrane protein complex|energy derivation by oxidation of organic compounds|regulation of organ growth|small molecule metabolic process|secretion by cell|organ growth|muscle structure development|cation binding|cell-cell signaling|regulation of protein localization|multicellular organism growth|establishment of protein localization|regulation of hormone secretion|positive regulation of developmental growth|substrate-specific transmembrane transporter activity|regulation of cell communication|protein localization|transmembrane transporter complex|cell communication|transmembrane transport|positive regulation of organ growth|regulation of developmental growth|synapse organization|regulation of multicellular organism growth|generation of precursor metabolites and energy|regulation of hormone levels|cellular developmental process|integral component of membrane|oxidation-reduction process|metal ion binding|regulation of peptide hormone secretion|neuromuscular junction development|muscle cell differentiation|regulation of protein transport|protein transport|regulation of establishment of protein localization|channel activity|amide transport|ion transport|ion transmembrane transporter activity|voltage-gated calcium channel complex|rhythmic synaptic transmission|regulation of secretion|hormone transport|protein secretion|regulation of ion transmembrane transport|ion channel complex|muscle cell development|regulation of ion transport|energy reserve metabolic process|secretion|cell differentiation|ion transmembrane transport|regulation of insulin secretion|striated muscle cell development|peptide secretion|insulin secretion|cation transmembrane transport|ion channel activity|cation channel complex|cation transport|regulation of protein secretion|peptide transport|striated muscle cell differentiation|hormone secretion|cation transmembrane transporter activity|peptide hormone secretion|voltage-gated ion channel activity|muscle fiber development|calcium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|synaptic transmission|calcium channel activity|calcium ion transmembrane transport|voltage-gated cation channel activity|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity|voltage-gated calcium channel activity K04859 voltage-dependent calcium channel alpha-2/delta-2[-] hsa04010|hsa04921|hsa04261|hsa05414|hsa05410|hsa04260|hsa05412 MAPK signaling pathway - Homo sapiens (human)|Oxytocin signaling pathway - Homo sapiens (human)|Adrenergic signaling in cardiomyocytes - Homo sapiens (human)|Dilated cardiomyopathy - Homo sapiens (human)|Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)|Cardiac muscle contraction - Homo sapiens (human)|Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) 3:50362799-50504244 7 18 27 38 33 76 0.0366302760106232 0.0856022664168701 0.127383786783133 0.178163062645929 0.141683149237947 0.372714255027385 0.0832054430702088 0.23085348897042 -1.47222772282257 0.00327127237793346 0.0163121038200811 DOWN ENSG00000234949 AC104667.3 - - - - - - - 2:237591020-237595981 35 43 32 25 15 15 1.30993338339107 1.46263725611527 1.07980471721751 0.838354103738013 0.460634754323644 0.5261519651675 1.28412511890795 0.608380274409719 1.07774049624871 0.00327428658225412 0.0163216816875296 UP ENSG00000184669 OR7E14P olfactory receptor family 7 subfamily E member 14 pseudogene [Source:HGNC Symbol;Acc:HGNC:8385] - - - - - - 11:17013998-17053024 55 61 42 133 138 80 1.94817807437222 1.96372351100706 1.34131769429556 4.22101395330737 4.01063501537538 2.65573073659042 1.75107309322495 3.62912656842439 -1.05138306678317 0.00328067693524658 0.0163426212622812 DOWN ENSG00000196233 LCOR ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0009890|GO:0006139|GO:0008134|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|transcription factor binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 10:96832260-96981043 206 236 773 598 1032 1208 0.683896211423991 0.712057224886676 2.31375287936179 1.77878009549192 2.81106616918273 3.75854246546163 1.23656877189082 2.78279624337876 -1.17019280067827 0.00328705496133905 0.016366200603038 DOWN ENSG00000262664 OVCA2 ovarian tumor suppressor candidate 2 [Source:HGNC Symbol;Acc:HGNC:24203] GO:0005623|GO:0050896|GO:0003824|GO:0043229|GO:0043227|GO:0016787|GO:0005622|GO:0043231|GO:0005737|GO:0010033|GO:0033993|GO:0032526|GO:0005634 cell|response to stimulus|catalytic activity|intracellular organelle|membrane-bounded organelle|hydrolase activity|intracellular|intracellular membrane-bounded organelle|cytoplasm|response to organic substance|response to lipid|response to retinoic acid|nucleus - - - - 17:2041936-2043430 112 217 69 74 70 45 7.06110215319775 12.4334892832584 3.92209043248006 4.18008454231879 3.62092895760844 2.65883344540938 7.80556062297874 3.48661564844554 1.16267491984749 0.00329127726623044 0.016379028422411 UP ENSG00000163082 SGPP2 sphingosine-1-phosphate phosphatase 2 [Source:HGNC Symbol;Acc:HGNC:19953] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0044255|GO:0016788|GO:0044281|GO:0043231|GO:0005737|GO:0006629|GO:0005783|GO:0016021|GO:0044249|GO:0006665|GO:0006066|GO:0006670|GO:0006643|GO:0006796|GO:0008610|GO:0042578|GO:0016311|GO:0016791|GO:0030148|GO:0042392 cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|intracellular membrane-bounded organelle|cytoplasm|lipid metabolic process|endoplasmic reticulum|integral component of membrane|cellular biosynthetic process|sphingolipid metabolic process|alcohol metabolic process|sphingosine metabolic process|membrane lipid metabolic process|phosphate-containing compound metabolic process|lipid biosynthetic process|phosphoric ester hydrolase activity|dephosphorylation|phosphatase activity|sphingolipid biosynthetic process|sphingosine-1-phosphate phosphatase activity K04717 sphingosine-1-phosphate phosphotase 2 [EC:3.1.3.-][-] hsa04071|hsa00600 Sphingolipid signaling pathway - Homo sapiens (human)|Sphingolipid metabolism - Homo sapiens (human) 2:222424517-222560948 4 2 6 13 10 23 0.0848124255973202 0.0385415480090345 0.114708726612794 0.246978124934901 0.173980752532312 0.457069452619521 0.0793542334063829 0.292676110028911 -1.88292589374638 0.00329412551623322 0.0163877392370649 DOWN ENSG00000273137 RP3-402G11.28 - - - - - - - 22:50208461-50209542 33 32 39 11 17 24 3.64735463861374 3.21436510395347 3.88642289639837 1.08930831182681 1.5416687804554 2.48604599893194 3.58271421298853 1.70567436373805 1.0707107238264 0.00329562604472862 0.016392472499055 UP ENSG00000271997 RP11-97O12.6 - - - - - - - 15:88501944-88505787 7 5 20 23 26 53 0.128815835356817 0.0836282349253947 0.331831696132745 0.379221527276581 0.392561025586602 0.914039439521714 0.181425255471652 0.561940664128299 -1.63104250133597 0.00330197298007502 0.0164213062380743 DOWN ENSG00000235241 RP11-108M9.5 - - - - - - - 1:16889095-16889602 20 27 35 10 15 14 2.78491637777992 3.41690468659989 4.39409142855926 1.2476545788747 1.71377890880253 1.82705013541114 3.53197083097969 1.59616120769612 1.14586706146788 0.00331707720620431 0.0164826935609227 UP ENSG00000269843 CTC-490E21.10 - - - - - - - 19:40831221-40837210 1 3 2 8 5 17 0.14681886602202 0.400191557873606 0.264639219903376 1.05196435861966 0.602074471418871 2.33817158697513 0.270549881266334 1.33073680567122 -2.29825874864224 0.00332173664963696 0.0164948645938559 DOWN ENSG00000108947 EFNB3 ephrin-B3 [Source:HGNC Symbol;Acc:HGNC:3228] GO:0040011|GO:0032502|GO:0004871|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0004872|GO:0050794|GO:0045321|GO:0038023|GO:0009653|GO:0016043|GO:0007155|GO:0044708|GO:0071944|GO:0009605|GO:0031224|GO:0002684|GO:0002682|GO:0005515|GO:0005886|GO:0016740|GO:0007626|GO:0048856|GO:0016032|GO:0016337|GO:0008344|GO:0006935|GO:0048468|GO:0030534|GO:0050867|GO:0007275|GO:0070489|GO:0005102|GO:0030155|GO:0001618|GO:0016772|GO:0098609|GO:0005887|GO:0004888|GO:0007267|GO:0006928|GO:0002696|GO:0001775|GO:0008037|GO:0031226|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0045785|GO:0031295|GO:0030030|GO:0048869|GO:0016021|GO:0051701|GO:0051249|GO:0000902|GO:0031175|GO:0007166|GO:0034109|GO:0000904|GO:0007628|GO:0051251|GO:0022407|GO:0007159|GO:0008038|GO:0046875|GO:0016301|GO:0042110|GO:0032990|GO:0007399|GO:0019058|GO:0097485|GO:0030154|GO:0022409|GO:0048858|GO:0016773|GO:0048666|GO:0030182|GO:0007411|GO:0050863|GO:0046718|GO:0016198|GO:0034112|GO:0070486|GO:0061564|GO:0007167|GO:0004672|GO:0022008|GO:0030260|GO:0048667|GO:0004714|GO:0050870|GO:0048812|GO:1903039|GO:0007409|GO:0048699|GO:0004713|GO:0005003|GO:0071593|GO:0007169|GO:0005005|GO:0048013 locomotion|developmental process|signal transducer activity|immune system process|behavior|signaling|cell|membrane|cellular process|response to stimulus|binding|catalytic activity|cellular response to stimulus|receptor activity|regulation of cellular process|leukocyte activation|signaling receptor activity|anatomical structure morphogenesis|cellular component organization|cell adhesion|single-organism behavior|cell periphery|response to external stimulus|intrinsic component of membrane|positive regulation of immune system process|regulation of immune system process|protein binding|plasma membrane|transferase activity|locomotory behavior|anatomical structure development|viral process|single organismal cell-cell adhesion|adult locomotory behavior|chemotaxis|cell development|adult behavior|positive regulation of cell activation|multicellular organism development|T cell aggregation|receptor binding|regulation of cell adhesion|virus receptor activity|transferase activity, transferring phosphorus-containing groups|cell-cell adhesion|integral component of plasma membrane|transmembrane signaling receptor activity|cell-cell signaling|movement of cell or subcellular component|positive regulation of leukocyte activation|cell activation|cell recognition|intrinsic component of plasma membrane|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|positive regulation of cell adhesion|T cell costimulation|cell projection organization|cellular developmental process|integral component of membrane|interaction with host|regulation of lymphocyte activation|cell morphogenesis|neuron projection development|cell surface receptor signaling pathway|homotypic cell-cell adhesion|cell morphogenesis involved in differentiation|adult walking behavior|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|neuron recognition|ephrin receptor binding|kinase activity|T cell activation|cell part morphogenesis|nervous system development|viral life cycle|neuron projection guidance|cell differentiation|positive regulation of cell-cell adhesion|cell projection morphogenesis|phosphotransferase activity, alcohol group as acceptor|neuron development|neuron differentiation|axon guidance|regulation of T cell activation|viral entry into host cell|axon choice point recognition|positive regulation of homotypic cell-cell adhesion|leukocyte aggregation|axon development|enzyme linked receptor protein signaling pathway|protein kinase activity|neurogenesis|entry into host cell|cell morphogenesis involved in neuron differentiation|transmembrane receptor protein tyrosine kinase activity|positive regulation of T cell activation|neuron projection morphogenesis|positive regulation of leukocyte cell-cell adhesion|axonogenesis|generation of neurons|protein tyrosine kinase activity|ephrin receptor activity|lymphocyte aggregation|transmembrane receptor protein tyrosine kinase signaling pathway|transmembrane-ephrin receptor activity|ephrin receptor signaling pathway K05463 ephrin-B[-] hsa04360 Axon guidance - Homo sapiens (human) 17:7705202-7711378 10 9 3 3 1 0 0.219533094190456 0.179582912281035 0.0593733028594884 0.0590038791789204 0.0180208651720523 0 0.152829769776993 0.0256749147836576 2.57349420065273 0.00334626635981699 0.0166028645348141 UP ENSG00000243414 TICAM2 toll-like receptor adaptor molecule 2 [Source:HGNC Symbol;Acc:HGNC:21354] GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0002683|GO:0048523|GO:0050794|GO:0043229|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0051707|GO:0043227|GO:0008289|GO:0071944|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0019222|GO:0001818|GO:0002757|GO:0045087|GO:0060760|GO:0010941|GO:0034123|GO:0043168|GO:0006952|GO:0005543|GO:0031325|GO:0010942|GO:0001817|GO:0034122|GO:0043231|GO:0005737|GO:0002218|GO:0001816|GO:0009966|GO:0001819|GO:0010646|GO:0043085|GO:0009617|GO:0050776|GO:0007154|GO:0007165|GO:0050778|GO:0005783|GO:0009968|GO:0008219|GO:0010008|GO:0050790|GO:0009967|GO:0019538|GO:0010033|GO:0031323|GO:0005794|GO:0005768|GO:1902533|GO:2001235|GO:0032268|GO:0007166|GO:0001959|GO:0033993|GO:0032675|GO:0002758|GO:0034097|GO:0051345|GO:0032635|GO:0002237|GO:0032642|GO:0005769|GO:0051604|GO:0034145|GO:0032755|GO:0001961|GO:0071219|GO:0006954|GO:0032602|GO:0005770|GO:0051247|GO:0006508|GO:0002764|GO:0031901|GO:0032270|GO:0012501|GO:0034144|GO:0035556|GO:0044267|GO:0032609|GO:0010467|GO:0071310|GO:0051246|GO:0043068|GO:0034121|GO:0032729|GO:1902531|GO:0032496|GO:0031902|GO:0043067|GO:0045089|GO:0032722|GO:0032682|GO:0097190|GO:0045088|GO:0032649|GO:0071650|GO:0070671|GO:0019221|GO:0043122|GO:0071651|GO:0043065|GO:0016485|GO:0097296|GO:0030162|GO:0045862|GO:0052547|GO:0002221|GO:0070673|GO:0043123|GO:0007249|GO:2001269|GO:0042981|GO:0071345|GO:0010952|GO:0071396|GO:0097191|GO:0071609|GO:2000494|GO:0006915|GO:0071222|GO:0071351|GO:0010950|GO:0002224|GO:0043281|GO:0035655|GO:0031638|GO:0043280|GO:0006919|GO:0052548|GO:2001056|GO:0002756|GO:0034138|GO:2000116|GO:0034142|GO:0097202|GO:0035669|GO:0035666 signal transducer activity|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of immune system process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|response to other organism|membrane-bounded organelle|lipid binding|cell periphery|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of metabolic process|negative regulation of cytokine production|immune response-activating signal transduction|innate immune response|positive regulation of response to cytokine stimulus|regulation of cell death|positive regulation of toll-like receptor signaling pathway|anion binding|defense response|phospholipid binding|positive regulation of cellular metabolic process|positive regulation of cell death|regulation of cytokine production|negative regulation of toll-like receptor signaling pathway|intracellular membrane-bounded organelle|cytoplasm|activation of innate immune response|cytokine production|regulation of signal transduction|positive regulation of cytokine production|regulation of cell communication|positive regulation of catalytic activity|response to bacterium|regulation of immune response|cell communication|signal transduction|positive regulation of immune response|endoplasmic reticulum|negative regulation of signal transduction|cell death|endosome membrane|regulation of catalytic activity|positive regulation of signal transduction|protein metabolic process|response to organic substance|regulation of cellular metabolic process|Golgi apparatus|endosome|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|cell surface receptor signaling pathway|regulation of cytokine-mediated signaling pathway|response to lipid|regulation of interleukin-6 production|innate immune response-activating signal transduction|response to cytokine|positive regulation of hydrolase activity|interleukin-6 production|response to molecule of bacterial origin|regulation of chemokine production|early endosome|protein maturation|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of interleukin-6 production|positive regulation of cytokine-mediated signaling pathway|cellular response to molecule of bacterial origin|inflammatory response|chemokine production|late endosome|positive regulation of protein metabolic process|proteolysis|immune response-regulating signaling pathway|early endosome membrane|positive regulation of cellular protein metabolic process|programmed cell death|negative regulation of toll-like receptor 4 signaling pathway|intracellular signal transduction|cellular protein metabolic process|interferon-gamma production|gene expression|cellular response to organic substance|regulation of protein metabolic process|positive regulation of programmed cell death|regulation of toll-like receptor signaling pathway|positive regulation of interferon-gamma production|regulation of intracellular signal transduction|response to lipopolysaccharide|late endosome membrane|regulation of programmed cell death|positive regulation of innate immune response|positive regulation of chemokine production|negative regulation of chemokine production|apoptotic signaling pathway|regulation of innate immune response|regulation of interferon-gamma production|negative regulation of chemokine (C-C motif) ligand 5 production|response to interleukin-12|cytokine-mediated signaling pathway|regulation of I-kappaB kinase/NF-kappaB signaling|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of apoptotic process|protein processing|activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|regulation of proteolysis|positive regulation of proteolysis|regulation of peptidase activity|pattern recognition receptor signaling pathway|response to interleukin-18|positive regulation of I-kappaB kinase/NF-kappaB signaling|I-kappaB kinase/NF-kappaB signaling|positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway|regulation of apoptotic process|cellular response to cytokine stimulus|positive regulation of peptidase activity|cellular response to lipid|extrinsic apoptotic signaling pathway|chemokine (C-C motif) ligand 5 production|positive regulation of interleukin-18-mediated signaling pathway|apoptotic process|cellular response to lipopolysaccharide|cellular response to interleukin-18|positive regulation of endopeptidase activity|toll-like receptor signaling pathway|regulation of cysteine-type endopeptidase activity involved in apoptotic process|interleukin-18-mediated signaling pathway|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|activation of cysteine-type endopeptidase activity involved in apoptotic process|regulation of endopeptidase activity|positive regulation of cysteine-type endopeptidase activity|MyD88-independent toll-like receptor signaling pathway|toll-like receptor 3 signaling pathway|regulation of cysteine-type endopeptidase activity|toll-like receptor 4 signaling pathway|activation of cysteine-type endopeptidase activity|TRAM-dependent toll-like receptor 4 signaling pathway|TRIF-dependent toll-like receptor signaling pathway K05409 TRIF-related adaptor molecule[-] hsa05161|hsa04620|hsa04064|hsa05133 Hepatitis B - Homo sapiens (human)|Toll-like receptor signaling pathway - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|Pertussis - Homo sapiens (human) 5:115578650-115602479 20 19 16 33 35 98 0.423954905577524 0.366044100737246 0.305798271485591 0.626752160235984 0.608732737554191 1.94691316991945 0.365265759266787 1.06079935590321 -1.53813338051654 0.0033646300250295 0.0166801170320875 DOWN ENSG00000197301 RP11-366L20.2 - - - - - - - 12:65851340-65882167 0 1 1 10 5 3 0 0.0101176225793518 0.0100274780273469 0.0997024580884611 0.0456504475733673 0.0312816165067098 0.00671503353556623 0.0588781740561794 -3.13226642113944 0.00343796170044033 0.0170182239437814 DOWN ENSG00000116668 SWT1 SWT1, RNA endoribonuclease homolog [Source:HGNC Symbol;Acc:HGNC:16785] - - - - - - 1:185157080-185291765 22 44 54 82 76 101 0.33473965278738 0.608440802641225 0.740793301671067 1.11788289075593 0.948781951365022 1.44024660876626 0.561324585699891 1.16897048362907 -1.05833134742029 0.00344325099941697 0.0170415807918757 DOWN ENSG00000136928 GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 [Source:HGNC Symbol;Acc:HGNC:4507] GO:0032991|GO:0004871|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0004872|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0038023|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0097060|GO:0019222|GO:0006725|GO:1901360|GO:0098797|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0045211|GO:0005887|GO:0004888|GO:0005737|GO:0007267|GO:0043235|GO:0043005|GO:0009890|GO:0006139|GO:0031226|GO:0055086|GO:0007154|GO:0044092|GO:0007165|GO:0050790|GO:0043086|GO:0016021|GO:0044249|GO:0031324|GO:0031323|GO:0007186|GO:0051350|GO:0019693|GO:0031279|GO:0016917|GO:0006796|GO:1901137|GO:0051174|GO:0004930|GO:0004965|GO:0009259|GO:0009117|GO:0046390|GO:0045980|GO:0007214|GO:0007194|GO:0045761|GO:0006163|GO:0038037|GO:0009165|GO:0006164|GO:0009187|GO:0038039|GO:0030802|GO:0007268|GO:0009190|GO:0030818|GO:0046058|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030815|GO:0006171 macromolecular complex|signal transducer activity|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|signaling receptor activity|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|synaptic membrane|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|plasma membrane protein complex|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|postsynaptic membrane|integral component of plasma membrane|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|receptor complex|neuron projection|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|nucleobase-containing small molecule metabolic process|cell communication|negative regulation of molecular function|signal transduction|regulation of catalytic activity|negative regulation of catalytic activity|integral component of membrane|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|G-protein coupled receptor signaling pathway|negative regulation of lyase activity|ribose phosphate metabolic process|regulation of cyclase activity|GABA receptor activity|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|G-protein coupled receptor activity|G-protein coupled GABA receptor activity|ribonucleotide metabolic process|nucleotide metabolic process|ribose phosphate biosynthetic process|negative regulation of nucleotide metabolic process|gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|regulation of adenylate cyclase activity|purine nucleotide metabolic process|G-protein coupled receptor dimeric complex|nucleotide biosynthetic process|purine nucleotide biosynthetic process|cyclic nucleotide metabolic process|G-protein coupled receptor heterodimeric complex|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|cyclic nucleotide biosynthetic process|negative regulation of cAMP biosynthetic process|cAMP metabolic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|negative regulation of cAMP metabolic process|cAMP biosynthetic process K04615 gamma-aminobutyric acid type B receptor[-] hsa04080|hsa04024|hsa04915|hsa05032|hsa04727|hsa04742 Neuroactive ligand-receptor interaction - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Estrogen signaling pathway - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Taste transduction - Homo sapiens (human) 9:98288082-98709197 1 1 0 10 5 3 0.00886578469338685 0.00805784599560754 0 0.0794047263929275 0.0363567896797664 0.0249132092374285 0.0056412102296648 0.0468915751033741 -3.05525213283528 0.00344952880593684 0.0170641645356153 DOWN ENSG00000260735 RP11-72I8.1 - - - - - - - 16:15094411-15109197 13 12 19 7 6 4 0.353952828637642 0.296939039626187 0.46641632554299 0.170759780270139 0.134028099099043 0.102056574869466 0.372436064602273 0.135614818079549 1.45747795758414 0.00345137890581345 0.017070488047408 UP ENSG00000213089 PDCL3P5 phosducin-like 3 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:44506] - - - - - - 6:150827663-150828384 58 60 25 28 23 13 5.68247290005577 5.34243507582295 2.20833507720356 2.45789439720128 1.84885459965481 1.19370598810407 4.41108101769409 1.83348499498672 1.26654379918591 0.00346266962820497 0.017117703178669 UP ENSG00000278616 BEND3P3 BEN domain containing 3 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:45016] - - - - - - 10:79682997-79685436 23 33 51 81 59 100 0.66679153247178 0.869471882486542 1.33302480709089 2.1039708055834 1.40339237448912 2.71697571261337 0.956429407349737 2.0747796308953 -1.11722771684496 0.00346321857034772 0.017117703178669 DOWN ENSG00000118513 MYB v-myb avian myeloblastosis viral oncogene homolog [Source:HGNC Symbol;Acc:HGNC:7545] GO:0032502|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0032259|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0016043|GO:0007155|GO:0043227|GO:0009893|GO:0009058|GO:0031224|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:1903706|GO:0050817|GO:0016337|GO:0002286|GO:0045595|GO:0006725|GO:0050867|GO:0051130|GO:1901360|GO:0007275|GO:0016570|GO:0003676|GO:0048513|GO:0070489|GO:0034641|GO:0030155|GO:0031325|GO:0046483|GO:0051128|GO:0098609|GO:0045597|GO:0043231|GO:0000981|GO:0009611|GO:0002696|GO:0001775|GO:0002263|GO:0009890|GO:0006139|GO:0050776|GO:0046649|GO:0050865|GO:0002366|GO:0050778|GO:0045785|GO:0048869|GO:0016021|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0002292|GO:0050878|GO:0006996|GO:0051276|GO:0000982|GO:0051249|GO:0032268|GO:0003677|GO:0010468|GO:0034645|GO:0043412|GO:0030097|GO:0030098|GO:0010629|GO:0031056|GO:0007596|GO:0051252|GO:0016571|GO:0006479|GO:0006325|GO:0034109|GO:0045622|GO:0031058|GO:0010628|GO:0036211|GO:0042060|GO:0051251|GO:0022407|GO:0031981|GO:0007599|GO:0007159|GO:0051247|GO:0016363|GO:0032270|GO:0042110|GO:0033043|GO:0044267|GO:0045624|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0034399|GO:0022409|GO:0001228|GO:0042093|GO:0016070|GO:0010557|GO:0005634|GO:0061647|GO:0010638|GO:2001252|GO:0002521|GO:0031062|GO:0000975|GO:0045893|GO:0031401|GO:0050863|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0030217|GO:0001077|GO:0045619|GO:0033044|GO:0034112|GO:1902679|GO:0070486|GO:0003690|GO:0046631|GO:0031060|GO:0051567|GO:0018022|GO:0034968|GO:0016568|GO:0006464|GO:0050870|GO:0045621|GO:0006351|GO:0006355|GO:1903039|GO:0045582|GO:0045944|GO:0006366|GO:1903507|GO:0051574|GO:0006357|GO:0051568|GO:0046632|GO:0045580|GO:1903506|GO:0044212|GO:0051571|GO:0018193|GO:0051569|GO:0006338|GO:0035710|GO:0000122|GO:0071593|GO:0051570|GO:0046638|GO:0000976|GO:0001012|GO:0001159|GO:0043367|GO:0018205|GO:2000516|GO:0043372|GO:0000977|GO:0043370|GO:0000987|GO:0000978 developmental process|immune system process|cell|membrane|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|methylation|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|cellular component organization|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|regulation of hemopoiesis|coagulation|single organismal cell-cell adhesion|T cell activation involved in immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|positive regulation of cell activation|positive regulation of cellular component organization|organic cyclic compound metabolic process|multicellular organism development|histone modification|nucleic acid binding|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|RNA polymerase II transcription factor activity, sequence-specific DNA binding|response to wounding|positive regulation of leukocyte activation|cell activation|cell activation involved in immune response|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|regulation of immune response|lymphocyte activation|regulation of cell activation|leukocyte activation involved in immune response|positive regulation of immune response|positive regulation of cell adhesion|cellular developmental process|integral component of membrane|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|T cell differentiation involved in immune response|regulation of body fluid levels|organelle organization|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of lymphocyte activation|regulation of cellular protein metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|hemopoiesis|lymphocyte differentiation|negative regulation of gene expression|regulation of histone modification|blood coagulation|regulation of RNA metabolic process|histone methylation|protein methylation|chromatin organization|homotypic cell-cell adhesion|regulation of T-helper cell differentiation|positive regulation of histone modification|positive regulation of gene expression|protein modification process|wound healing|positive regulation of lymphocyte activation|regulation of cell-cell adhesion|nuclear lumen|hemostasis|leukocyte cell-cell adhesion|positive regulation of protein metabolic process|nuclear matrix|positive regulation of cellular protein metabolic process|T cell activation|regulation of organelle organization|cellular protein metabolic process|positive regulation of T-helper cell differentiation|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|nuclear periphery|positive regulation of cell-cell adhesion|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|T-helper cell differentiation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|histone H3-K9 modification|positive regulation of organelle organization|positive regulation of chromosome organization|leukocyte differentiation|positive regulation of histone methylation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|positive regulation of protein modification process|regulation of T cell activation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|T cell differentiation|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of lymphocyte differentiation|regulation of chromosome organization|positive regulation of homotypic cell-cell adhesion|negative regulation of RNA biosynthetic process|leukocyte aggregation|double-stranded DNA binding|alpha-beta T cell activation|regulation of histone methylation|histone H3-K9 methylation|peptidyl-lysine methylation|histone lysine methylation|chromatin modification|cellular protein modification process|positive regulation of T cell activation|positive regulation of lymphocyte differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of leukocyte cell-cell adhesion|positive regulation of T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|positive regulation of histone H3-K9 methylation|regulation of transcription from RNA polymerase II promoter|histone H3-K4 methylation|alpha-beta T cell differentiation|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|positive regulation of histone H3-K4 methylation|peptidyl-amino acid modification|regulation of histone H3-K4 methylation|chromatin remodeling|CD4-positive, alpha-beta T cell activation|negative regulation of transcription from RNA polymerase II promoter|lymphocyte aggregation|regulation of histone H3-K9 methylation|positive regulation of alpha-beta T cell differentiation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|CD4-positive, alpha-beta T cell differentiation|peptidyl-lysine modification|positive regulation of CD4-positive, alpha-beta T cell activation|positive regulation of CD4-positive, alpha-beta T cell differentiation|RNA polymerase II regulatory region sequence-specific DNA binding|regulation of CD4-positive, alpha-beta T cell differentiation|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding K09420 myb proto-oncogene protein[-] hsa04151|hsa05166 PI3K-Akt signaling pathway - Homo sapiens (human)|HTLV-I infection - Homo sapiens (human) 6:135181315-135219173 51 67 152 35 56 42 0.257960483570158 0.307992825452665 0.693171033971076 0.158615206572839 0.232402276178001 0.199095737548528 0.4197081143313 0.196704406766456 1.09335707685154 0.00346379941357866 0.0171177400584303 UP ENSG00000152785 BMP3 bone morphogenetic protein 3 [Source:HGNC Symbol;Acc:HGNC:1070] GO:0032502|GO:0040007|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0023051|GO:0043227|GO:0009893|GO:0009058|GO:0005615|GO:0005515|GO:0048856|GO:0019222|GO:0006725|GO:0009888|GO:0048468|GO:1901360|GO:0010941|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0031982|GO:0031325|GO:0046483|GO:0007267|GO:0009966|GO:0010646|GO:0006139|GO:0007154|GO:0007165|GO:0070062|GO:0001503|GO:0008219|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0000165|GO:0032268|GO:0010468|GO:0005126|GO:0071773|GO:0034645|GO:0051216|GO:0007166|GO:0043412|GO:0051252|GO:0005125|GO:0036211|GO:0001649|GO:0033612|GO:0051247|GO:0070848|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0071310|GO:0060395|GO:0051246|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:1902531|GO:0016070|GO:0008083|GO:0043067|GO:0060393|GO:0031401|GO:0043408|GO:0032774|GO:2001141|GO:0071363|GO:0016310|GO:0030509|GO:0007167|GO:0010862|GO:0042981|GO:0005160|GO:0006464|GO:0006351|GO:0006915|GO:0006355|GO:0006366|GO:0070700|GO:0006357|GO:0006468|GO:1903506|GO:0042325|GO:0001932|GO:0001934|GO:0007178|GO:0042327|GO:0060389 developmental process|growth|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|regulation of signaling|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|extracellular space|protein binding|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|tissue development|cell development|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|cell-cell signaling|regulation of signal transduction|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|signal transduction|extracellular exosome|ossification|cell death|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|regulation of gene expression|cytokine receptor binding|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|cartilage development|cell surface receptor signaling pathway|macromolecule modification|regulation of RNA metabolic process|cytokine activity|protein modification process|osteoblast differentiation|receptor serine/threonine kinase binding|positive regulation of protein metabolic process|response to growth factor|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cellular response to organic substance|SMAD protein signal transduction|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|regulation of intracellular signal transduction|RNA metabolic process|growth factor activity|regulation of programmed cell death|regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein modification process|regulation of MAPK cascade|RNA biosynthetic process|regulation of RNA biosynthetic process|cellular response to growth factor stimulus|phosphorylation|BMP signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of apoptotic process|transforming growth factor beta receptor binding|cellular protein modification process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|BMP receptor binding|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway|positive regulation of phosphorylation|pathway-restricted SMAD protein phosphorylation - - - - 4:81030965-81057531 25 19 39 48 54 114 0.308412707556239 0.213025665183151 0.433782813689389 0.530546335665151 0.546577868596018 1.31801389794473 0.318407062142926 0.798379367401966 -1.32620210280152 0.00346563420700377 0.0171183063560375 DOWN ENSG00000254213 RP11-434I12.5 - - - - - - - 8:73277364-73278046 10 2 3 0 0 1 1.03563049704488 0.188249786468725 0.280088992405961 0 0 0.0970508717096897 0.501323091973189 0.0323502905698966 3.95389011349597 0.00349558179615165 0.0172548113330541 UP ENSG00000270885 RASL10B RAS-like family 10 member B [Source:HGNC Symbol;Acc:HGNC:30295] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0097159|GO:0050794|GO:0051050|GO:0043167|GO:0051641|GO:0023051|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0060341|GO:0046887|GO:0006810|GO:0043168|GO:0032940|GO:0001882|GO:0007267|GO:0045184|GO:0046883|GO:0010646|GO:0008104|GO:0007154|GO:0007165|GO:0008217|GO:0051047|GO:0000166|GO:0010817|GO:0003013|GO:0090276|GO:0035639|GO:0002793|GO:0001883|GO:0015031|GO:0042886|GO:0032549|GO:0051046|GO:0009914|GO:0035556|GO:0046903|GO:0017076|GO:0008015|GO:0003073|GO:0090277|GO:0002790|GO:0032561|GO:0015833|GO:0005525|GO:0003050|GO:0007264|GO:0019001|GO:0046879|GO:0030072 signaling|cell|membrane|cellular process|response to stimulus|binding|small molecule binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|positive regulation of transport|ion binding|cellular localization|regulation of signaling|cell periphery|intracellular|protein binding|plasma membrane|regulation of cellular localization|positive regulation of hormone secretion|transport|anion binding|secretion by cell|nucleoside binding|cell-cell signaling|establishment of protein localization|regulation of hormone secretion|regulation of cell communication|protein localization|cell communication|signal transduction|regulation of blood pressure|positive regulation of secretion|nucleotide binding|regulation of hormone levels|circulatory system process|regulation of peptide hormone secretion|purine ribonucleoside triphosphate binding|positive regulation of peptide secretion|purine nucleoside binding|protein transport|amide transport|ribonucleoside binding|regulation of secretion|hormone transport|intracellular signal transduction|secretion|purine nucleotide binding|blood circulation|regulation of systemic arterial blood pressure|positive regulation of peptide hormone secretion|peptide secretion|guanyl ribonucleotide binding|peptide transport|GTP binding|regulation of systemic arterial blood pressure by atrial natriuretic peptide|small GTPase mediated signal transduction|guanyl nucleotide binding|hormone secretion|peptide hormone secretion - - - - 17:35731649-35743521 4 4 1 0 0 0 0.0793421906317051 0.0721113876377672 0.0178756808244096 0 0 0 0.0564430863646273 0 Inf 0.00349875659927465 0.0172676276268384 UP ENSG00000278619 MRM1 mitochondrial rRNA methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:26202] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0032259|GO:0097159|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0016740|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0022613|GO:0008168|GO:0003723|GO:0043412|GO:0042254|GO:0001510|GO:0005739|GO:0010467|GO:0016070|GO:0006364|GO:0006396|GO:0034660|GO:0031167|GO:0009451|GO:0044822|GO:0008171|GO:0008173|GO:0008757|GO:0070039|GO:0008649|GO:0016072|GO:0000154|GO:0000453|GO:0016435 cell|cellular process|metabolic process|binding|catalytic activity|methylation|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|transferase activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|ribonucleoprotein complex biogenesis|methyltransferase activity|RNA binding|macromolecule modification|ribosome biogenesis|RNA methylation|mitochondrion|gene expression|RNA metabolic process|rRNA processing|RNA processing|ncRNA metabolic process|rRNA methylation|RNA modification|poly(A) RNA binding|O-methyltransferase activity|RNA methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity|rRNA (guanosine-2'-O-)-methyltransferase activity|rRNA methyltransferase activity|rRNA metabolic process|rRNA modification|enzyme-directed rRNA 2'-O-methylation|rRNA (guanine) methyltransferase activity - - - - 17:36601572-36608971 32 59 52 119 131 68 0.81016697789516 1.35754518515496 1.18696920382082 2.69939049623163 2.72119828847885 1.61345555464855 1.11822712229031 2.34468144645301 -1.06817868567802 0.00351512803682459 0.0173369622354801 DOWN ENSG00000021762 OSBPL5 oxysterol binding protein like 5 [Source:HGNC Symbol;Acc:HGNC:16392] GO:0005215|GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0051641|GO:0072341|GO:0043227|GO:0008289|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0006810|GO:1901360|GO:0005496|GO:0043168|GO:0044281|GO:0005543|GO:0043231|GO:0043178|GO:0005737|GO:0043177|GO:0005319|GO:0001786|GO:0006629|GO:0005783|GO:0051649|GO:0016021|GO:0010876|GO:0016192|GO:0005829|GO:0005548|GO:0035091|GO:0006066|GO:0032934|GO:0046907|GO:0006811|GO:0006869|GO:0008202|GO:0031406|GO:0015914|GO:0006820|GO:0015711|GO:0048193|GO:0008142|GO:1901981|GO:0016125|GO:0015918|GO:0016597|GO:0015485|GO:0030301|GO:0070273|GO:0008203|GO:0006892|GO:0006893 transporter activity|cell|membrane|metabolic process|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|cellular localization|modified amino acid binding|membrane-bounded organelle|lipid binding|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|transport|organic cyclic compound metabolic process|steroid binding|anion binding|small molecule metabolic process|phospholipid binding|intracellular membrane-bounded organelle|alcohol binding|cytoplasm|organic acid binding|lipid transporter activity|phosphatidylserine binding|lipid metabolic process|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|lipid localization|vesicle-mediated transport|cytosol|phospholipid transporter activity|phosphatidylinositol binding|alcohol metabolic process|sterol binding|intracellular transport|ion transport|lipid transport|steroid metabolic process|carboxylic acid binding|phospholipid transport|anion transport|organic anion transport|Golgi vesicle transport|oxysterol binding|phosphatidylinositol phosphate binding|sterol metabolic process|sterol transport|amino acid binding|cholesterol binding|cholesterol transport|phosphatidylinositol-4-phosphate binding|cholesterol metabolic process|post-Golgi vesicle-mediated transport|Golgi to plasma membrane transport - - - - 11:3087116-3166739 16 18 55 63 58 121 0.0817895120768564 0.083622737203588 0.253482637468466 0.288541221180841 0.243258719913941 0.579676429051128 0.139631628916303 0.37049212338197 -1.40781709803686 0.00352420292568843 0.0173724544544894 DOWN ENSG00000115738 ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein [Source:HGNC Symbol;Acc:HGNC:5361] GO:0040011|GO:0032502|GO:0032991|GO:0002376|GO:0007610|GO:0005623|GO:0048511|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0042752|GO:0051716|GO:0002683|GO:0009892|GO:0048523|GO:0008283|GO:0007622|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0007623|GO:0071704|GO:0009628|GO:0044237|GO:0009653|GO:0016043|GO:0043227|GO:0044708|GO:0002262|GO:0009605|GO:0009893|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0007626|GO:0048856|GO:0019222|GO:0001966|GO:0007507|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:1903706|GO:0048565|GO:0003149|GO:0045648|GO:0008344|GO:0045595|GO:0035239|GO:0006725|GO:0001822|GO:0009888|GO:0048468|GO:0030534|GO:0009314|GO:0044325|GO:0022402|GO:0035295|GO:1901360|GO:0007275|GO:0060411|GO:0045596|GO:0048513|GO:0030279|GO:0034101|GO:0045475|GO:0034641|GO:0030900|GO:0031325|GO:0046483|GO:0033554|GO:0007420|GO:0032922|GO:0051098|GO:0045786|GO:0045597|GO:0043231|GO:0045646|GO:0005737|GO:0061377|GO:0060322|GO:0003161|GO:0009887|GO:0042592|GO:0001775|GO:0060749|GO:0046983|GO:0048598|GO:0048568|GO:0050673|GO:0009890|GO:0045787|GO:0021988|GO:0003166|GO:0006139|GO:0046649|GO:0050865|GO:0044092|GO:0021772|GO:0006629|GO:0030278|GO:0003279|GO:0001503|GO:0061351|GO:0002695|GO:0008285|GO:0008217|GO:0048869|GO:0010035|GO:0021537|GO:0044249|GO:0048512|GO:0031324|GO:0031323|GO:0048732|GO:0003013|GO:0009649|GO:0051090|GO:0007568|GO:0003205|GO:0050768|GO:0051249|GO:0000902|GO:0005829|GO:0061030|GO:0005813|GO:0030879|GO:0042113|GO:0010468|GO:0034645|GO:0048660|GO:0030101|GO:0030218|GO:0090068|GO:0055123|GO:0051101|GO:0045668|GO:0051100|GO:1903047|GO:0030097|GO:0072358|GO:0030098|GO:0007417|GO:0021782|GO:0001655|GO:0010629|GO:0010720|GO:2000178|GO:0051252|GO:0005815|GO:0048738|GO:0003007|GO:0044770|GO:0010721|GO:0045667|GO:0048659|GO:0007050|GO:0000904|GO:0009790|GO:0001656|GO:0010628|GO:0010038|GO:0048661|GO:0000278|GO:0060412|GO:0060537|GO:0048872|GO:0072001|GO:0048537|GO:0001649|GO:0051250|GO:0007569|GO:0031981|GO:0050769|GO:0003231|GO:0045600|GO:0007346|GO:0045777|GO:0010564|GO:0005654|GO:0043433|GO:0060429|GO:0071241|GO:0010467|GO:0048562|GO:0045639|GO:0007399|GO:0019216|GO:0045598|GO:0031328|GO:0009059|GO:0030154|GO:0061448|GO:0003281|GO:0048469|GO:0048566|GO:0048546|GO:2000177|GO:0016070|GO:0072359|GO:0008015|GO:0005856|GO:0010557|GO:0005634|GO:0033598|GO:0009416|GO:0090398|GO:0051960|GO:0045165|GO:0060612|GO:0045637|GO:0043153|GO:0048666|GO:0030182|GO:0000083|GO:0002521|GO:0002761|GO:0045893|GO:0045444|GO:0061031|GO:0010001|GO:0071156|GO:0030855|GO:0030183|GO:0050869|GO:0045892|GO:0045620|GO:0032774|GO:0048541|GO:0044772|GO:0010226|GO:2001141|GO:0014003|GO:0045619|GO:1902679|GO:0009648|GO:0048663|GO:0048557|GO:1901990|GO:0015630|GO:0001779|GO:0050864|GO:0002763|GO:0014015|GO:0048709|GO:0003229|GO:1901987|GO:0030099|GO:0045665|GO:0014706|GO:0022008|GO:0048667|GO:0061180|GO:0050767|GO:0048708|GO:0006351|GO:0043353|GO:0006355|GO:0071248|GO:0071158|GO:0043392|GO:0048715|GO:0045686|GO:0048710|GO:0060644|GO:0045577|GO:0045944|GO:2000045|GO:0006366|GO:0002573|GO:0071285|GO:1903507|GO:0006357|GO:0048699|GO:0014013|GO:1903506|GO:0045685|GO:0048711|GO:0045578|GO:1902806|GO:0045687|GO:0000082|GO:0042063|GO:0000122|GO:0071931|GO:0045651|GO:0045664|GO:0048713|GO:0030225 locomotion|developmental process|macromolecular complex|immune system process|behavior|cell|rhythmic process|cellular process|metabolic process|response to stimulus|binding|regulation of circadian rhythm|cellular response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|rhythmic behavior|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|circadian rhythm|organic substance metabolic process|response to abiotic stimulus|cellular metabolic process|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|single-organism behavior|myeloid cell homeostasis|response to external stimulus|positive regulation of metabolic process|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|locomotory behavior|anatomical structure development|regulation of metabolic process|thigmotaxis|heart development|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|regulation of hemopoiesis|digestive tract development|membranous septum morphogenesis|positive regulation of erythrocyte differentiation|adult locomotory behavior|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|kidney development|tissue development|cell development|adult behavior|response to radiation|ion channel binding|cell cycle process|tube development|organic cyclic compound metabolic process|multicellular organism development|cardiac septum morphogenesis|negative regulation of cell differentiation|animal organ development|negative regulation of ossification|erythrocyte homeostasis|locomotor rhythm|cellular nitrogen compound metabolic process|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|brain development|circadian regulation of gene expression|regulation of binding|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|regulation of erythrocyte differentiation|cytoplasm|mammary gland lobule development|head development|cardiac conduction system development|organ morphogenesis|homeostatic process|cell activation|mammary gland alveolus development|protein dimerization activity|embryonic morphogenesis|embryonic organ development|epithelial cell proliferation|negative regulation of biosynthetic process|positive regulation of cell cycle|olfactory lobe development|bundle of His development|nucleobase-containing compound metabolic process|lymphocyte activation|regulation of cell activation|negative regulation of molecular function|olfactory bulb development|lipid metabolic process|regulation of ossification|cardiac septum development|ossification|neural precursor cell proliferation|negative regulation of leukocyte activation|negative regulation of cell proliferation|regulation of blood pressure|cellular developmental process|response to inorganic substance|telencephalon development|cellular biosynthetic process|circadian behavior|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|circulatory system process|entrainment of circadian clock|regulation of sequence-specific DNA binding transcription factor activity|aging|cardiac chamber development|negative regulation of neurogenesis|regulation of lymphocyte activation|cell morphogenesis|cytosol|epithelial cell differentiation involved in mammary gland alveolus development|centrosome|mammary gland development|B cell activation|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of smooth muscle cell proliferation|natural killer cell activation|erythrocyte differentiation|positive regulation of cell cycle process|digestive system development|regulation of DNA binding|negative regulation of osteoblast differentiation|negative regulation of binding|mitotic cell cycle process|hemopoiesis|cardiovascular system development|lymphocyte differentiation|central nervous system development|glial cell development|urogenital system development|negative regulation of gene expression|positive regulation of cell development|negative regulation of neural precursor cell proliferation|regulation of RNA metabolic process|microtubule organizing center|cardiac muscle tissue development|heart morphogenesis|cell cycle phase transition|negative regulation of cell development|regulation of osteoblast differentiation|smooth muscle cell proliferation|cell cycle arrest|cell morphogenesis involved in differentiation|embryo development|metanephros development|positive regulation of gene expression|response to metal ion|positive regulation of smooth muscle cell proliferation|mitotic cell cycle|ventricular septum morphogenesis|muscle tissue development|homeostasis of number of cells|renal system development|mucosal-associated lymphoid tissue development|osteoblast differentiation|negative regulation of lymphocyte activation|cell aging|nuclear lumen|positive regulation of neurogenesis|cardiac ventricle development|positive regulation of fat cell differentiation|regulation of mitotic cell cycle|positive regulation of blood pressure|regulation of cell cycle process|nucleoplasm|negative regulation of sequence-specific DNA binding transcription factor activity|epithelium development|cellular response to inorganic substance|gene expression|embryonic organ morphogenesis|positive regulation of myeloid cell differentiation|nervous system development|regulation of lipid metabolic process|regulation of fat cell differentiation|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|connective tissue development|ventricular septum development|cell maturation|embryonic digestive tract development|digestive tract morphogenesis|regulation of neural precursor cell proliferation|RNA metabolic process|circulatory system development|blood circulation|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|mammary gland epithelial cell proliferation|response to light stimulus|cellular senescence|regulation of nervous system development|cell fate commitment|adipose tissue development|regulation of myeloid cell differentiation|entrainment of circadian clock by photoperiod|neuron development|neuron differentiation|regulation of transcription involved in G1/S transition of mitotic cell cycle|leukocyte differentiation|regulation of myeloid leukocyte differentiation|positive regulation of transcription, DNA-templated|fat cell differentiation|endodermal digestive tract morphogenesis|glial cell differentiation|regulation of cell cycle arrest|epithelial cell differentiation|B cell differentiation|negative regulation of B cell activation|negative regulation of transcription, DNA-templated|negative regulation of lymphocyte differentiation|RNA biosynthetic process|Peyer's patch development|mitotic cell cycle phase transition|response to lithium ion|regulation of RNA biosynthetic process|oligodendrocyte development|regulation of lymphocyte differentiation|negative regulation of RNA biosynthetic process|photoperiodism|neuron fate commitment|embryonic digestive tract morphogenesis|regulation of mitotic cell cycle phase transition|microtubule cytoskeleton|natural killer cell differentiation|regulation of B cell activation|positive regulation of myeloid leukocyte differentiation|positive regulation of gliogenesis|oligodendrocyte differentiation|ventricular cardiac muscle tissue development|regulation of cell cycle phase transition|myeloid cell differentiation|negative regulation of neuron differentiation|striated muscle tissue development|neurogenesis|cell morphogenesis involved in neuron differentiation|mammary gland epithelium development|regulation of neurogenesis|astrocyte differentiation|transcription, DNA-templated|enucleate erythrocyte differentiation|regulation of transcription, DNA-templated|cellular response to metal ion|positive regulation of cell cycle arrest|negative regulation of DNA binding|negative regulation of oligodendrocyte differentiation|negative regulation of glial cell differentiation|regulation of astrocyte differentiation|mammary gland epithelial cell differentiation|regulation of B cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|transcription from RNA polymerase II promoter|myeloid leukocyte differentiation|cellular response to lithium ion|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|generation of neurons|regulation of gliogenesis|regulation of nucleic acid-templated transcription|regulation of glial cell differentiation|positive regulation of astrocyte differentiation|negative regulation of B cell differentiation|regulation of cell cycle G1/S phase transition|positive regulation of glial cell differentiation|G1/S transition of mitotic cell cycle|gliogenesis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription involved in G1/S transition of mitotic cell cycle|positive regulation of macrophage differentiation|regulation of neuron differentiation|regulation of oligodendrocyte differentiation|macrophage differentiation K17693 DNA-binding protein inhibitor ID2[-] hsa05202|hsa04390|hsa04550|hsa04350 Transcriptional misregulation in cancer - Homo sapiens (human)|Hippo signaling pathway - Homo sapiens (human)|Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)|TGF-beta signaling pathway - Homo sapiens (human) 2:8678845-8684453 46 36 38 25 14 22 0.733515874101305 0.521718411822926 0.546325344346568 0.357188741222914 0.183168723644575 0.328786733219343 0.600519876756933 0.289714732695611 1.05157894783398 0.00352465186008046 0.0173724544544894 UP ENSG00000277209 RPPH1 ribonuclease P RNA component H1 [Source:HGNC Symbol;Acc:HGNC:19273] - - - - - - 14:20343075-20343407 21 11 8 1 7 4 4.46097361361806 2.12369593852142 1.5322054533745 0.190236617119556 1.22002471184285 0.796225169702319 2.70562500183799 0.735495499554908 1.87917347754714 0.00354864362703923 0.0174777628603438 UP ENSG00000173157 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 [Source:HGNC Symbol;Acc:HGNC:17178] GO:0032502|GO:0031012|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0048523|GO:0050794|GO:0005578|GO:0071704|GO:0043167|GO:0023051|GO:0016043|GO:0043473|GO:0016787|GO:0005615|GO:0050793|GO:0048856|GO:0045595|GO:0009888|GO:0010941|GO:0007275|GO:0043062|GO:0048066|GO:0045597|GO:0043169|GO:0008233|GO:0009966|GO:0060548|GO:0010646|GO:0007154|GO:0007165|GO:0048087|GO:0008219|GO:0048869|GO:0048070|GO:0009967|GO:0019538|GO:0050942|GO:0046872|GO:0043069|GO:0030856|GO:0006508|GO:0030858|GO:0012501|GO:0050931|GO:0060429|GO:0030198|GO:0030154|GO:0043067|GO:0045634|GO:0008237|GO:0030855|GO:0004175|GO:0042981|GO:0046914|GO:0043066|GO:0045636|GO:0030318|GO:0006915|GO:0008270|GO:0004222|GO:0060563 developmental process|extracellular matrix|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|proteinaceous extracellular matrix|organic substance metabolic process|ion binding|regulation of signaling|cellular component organization|pigmentation|hydrolase activity|extracellular space|regulation of developmental process|anatomical structure development|regulation of cell differentiation|tissue development|regulation of cell death|multicellular organism development|extracellular structure organization|developmental pigmentation|positive regulation of cell differentiation|cation binding|peptidase activity|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|cell communication|signal transduction|positive regulation of developmental pigmentation|cell death|cellular developmental process|regulation of developmental pigmentation|positive regulation of signal transduction|protein metabolic process|positive regulation of pigment cell differentiation|metal ion binding|negative regulation of programmed cell death|regulation of epithelial cell differentiation|proteolysis|positive regulation of epithelial cell differentiation|programmed cell death|pigment cell differentiation|epithelium development|extracellular matrix organization|cell differentiation|regulation of programmed cell death|regulation of melanocyte differentiation|metallopeptidase activity|epithelial cell differentiation|endopeptidase activity|regulation of apoptotic process|transition metal ion binding|negative regulation of apoptotic process|positive regulation of melanocyte differentiation|melanocyte differentiation|apoptotic process|zinc ion binding|metalloendopeptidase activity|neuroepithelial cell differentiation - - - - 12:43353866-43551921 12 15 17 27 34 47 0.0910705950356054 0.103458851608616 0.116317295329606 0.183590919566411 0.211702383610555 0.334283138424543 0.103615580657942 0.243192147200503 -1.23085568701457 0.00355121869222081 0.0174860766679136 DOWN ENSG00000163406 SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:10921] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0022857|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0006810|GO:0015197|GO:0031982|GO:0045184|GO:0022891|GO:0042493|GO:0008104|GO:0055085|GO:0070062|GO:0016021|GO:0015198|GO:0015031|GO:0042886|GO:0006811|GO:0015075|GO:0015893|GO:0015293|GO:0015992|GO:0006812|GO:0015833|GO:0008324|GO:0015333|GO:0006857|GO:0015672|GO:0015295 transporter activity|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|transmembrane transporter activity|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|transport|peptide transporter activity|vesicle|establishment of protein localization|substrate-specific transmembrane transporter activity|response to drug|protein localization|transmembrane transport|extracellular exosome|integral component of membrane|oligopeptide transporter activity|protein transport|amide transport|ion transport|ion transmembrane transporter activity|drug transport|symporter activity|proton transport|cation transport|peptide transport|cation transmembrane transporter activity|peptide:proton symporter activity|oligopeptide transport|monovalent inorganic cation transport|solute:proton symporter activity - - - - 3:121894089-121944102 7 4 15 27 19 29 0.0648805124622123 0.0336935545487786 0.125345572035356 0.224220513794355 0.144488515895077 0.251899654901078 0.0746398796821156 0.20686956153017 -1.47070281916822 0.00357609883929241 0.0175940762604212 DOWN ENSG00000102547 CAB39L calcium binding protein 39 like [Source:HGNC Symbol;Acc:HGNC:20290] GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0048523|GO:0050794|GO:0043227|GO:0005622|GO:0005515|GO:0051726|GO:0007049|GO:0022402|GO:0031982|GO:0045786|GO:0010243|GO:0005737|GO:0007154|GO:0007165|GO:0070062|GO:0009725|GO:0010033|GO:0005829|GO:0007166|GO:1901652|GO:0007050|GO:0071417|GO:0043434|GO:0071310|GO:0032870|GO:1901653|GO:0007167|GO:0071375|GO:0032868|GO:0032869|GO:0007169|GO:0008286 signaling|cell|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|membrane-bounded organelle|intracellular|protein binding|regulation of cell cycle|cell cycle|cell cycle process|vesicle|negative regulation of cell cycle|response to organonitrogen compound|cytoplasm|cell communication|signal transduction|extracellular exosome|response to hormone|response to organic substance|cytosol|cell surface receptor signaling pathway|response to peptide|cell cycle arrest|cellular response to organonitrogen compound|response to peptide hormone|cellular response to organic substance|cellular response to hormone stimulus|cellular response to peptide|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|response to insulin|cellular response to insulin stimulus|transmembrane receptor protein tyrosine kinase signaling pathway|insulin receptor signaling pathway K08272 calcium binding protein 39[-] hsa04152|hsa04150 AMPK signaling pathway - Homo sapiens (human)|mTOR signaling pathway - Homo sapiens (human) 13:49308650-49444126 83 115 193 254 186 426 0.514745212955264 0.648173782548734 1.07915690581921 1.41138204597928 0.946441401260292 2.47599976928178 0.747358633774403 1.61127440550712 -1.1083295928217 0.00360092010612543 0.0177016085704378 DOWN ENSG00000279362 AC092718.1 - - - - - - - 16:81170740-81181213 5 0 7 11 15 21 0.384040114240254 0 0.484704657763437 0.756956915927426 0.945276531673927 1.51155449124092 0.289581590667897 1.07126264628076 -1.88727044030264 0.00363293814790712 0.0178355098614733 DOWN ENSG00000174137 FAM53A family with sequence similarity 53 member A [Source:HGNC Symbol;Acc:HGNC:31860] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - 4:1617915-1684302 7 5 6 17 29 12 0.0590751695432599 0.0383520561981887 0.045653580527354 0.128542404582458 0.200796709903375 0.0949056861468646 0.0476936020896009 0.141414933544233 -1.56806682566715 0.00363865454735739 0.0178547654268257 DOWN ENSG00000184368 MAP7D2 MAP7 domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25899] GO:0005198|GO:0005623|GO:0009987|GO:0043229|GO:0016043|GO:0005622|GO:0007017|GO:0006996|GO:0007010|GO:0000226|GO:0005856|GO:0015630 structural molecule activity|cell|cellular process|intracellular organelle|cellular component organization|intracellular|microtubule-based process|organelle organization|cytoskeleton organization|microtubule cytoskeleton organization|cytoskeleton|microtubule cytoskeleton - - - - X:20006713-20116917 6 12 9 4 1 2 0.0603442880263032 0.109689695001967 0.0816108479729209 0.0360476909465859 0.00825582647296352 0.0188499204827863 0.0838816103337304 0.0210511459674452 1.99445578627739 0.00364034317443798 0.0178571812569292 UP ENSG00000230102 RP11-407B7.1 - - - - - - - 3:194005259-194070970 0 3 3 6 12 9 0 0.0132399156356015 0.0131306734719797 0.0261023485236467 0.0478047995241652 0.0409528605360605 0.00879019636919373 0.0382866695279575 -2.12287486879424 0.00365194927489103 0.0179052871822297 DOWN ENSG00000164393 ADGRF2 adhesion G protein-coupled receptor F2 [Source:HGNC Symbol;Acc:HGNC:18991] GO:0004871|GO:0023052|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0050794|GO:0038023|GO:0031224|GO:0004888|GO:0007154|GO:0007165|GO:0016021|GO:0007186|GO:0007166|GO:0004930 signal transducer activity|signaling|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|regulation of cellular process|signaling receptor activity|intrinsic component of membrane|transmembrane signaling receptor activity|cell communication|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|cell surface receptor signaling pathway|G-protein coupled receptor activity - - - - 6:47656436-47697797 2 3 9 0 0 1 0.0115370352223398 0.0157309028621007 0.0468087664160457 0 0 0.00540578579169125 0.0246922348334954 0.00180192859723042 3.77644366764716 0.00367042218232865 0.0179840446136943 UP ENSG00000164989 CCDC171 coiled-coil domain containing 171 [Source:HGNC Symbol;Acc:HGNC:29828] - - - - - - 9:15552897-16061663 6 3 7 11 30 15 0.0247782214904829 0.0112618128733698 0.026063345971516 0.0407027860561162 0.101654673633491 0.0580585715884268 0.0207011267784562 0.0668053437593447 -1.69025421161243 0.00368016550277686 0.0180258672551108 DOWN ENSG00000244701 RP5-894A10.2 - - - - - - - 7:141652381-141656810 13 9 15 33 27 32 1.19424603740337 0.7514495368435 1.24238624126472 2.71619734897075 2.03507751764976 2.75509859621894 1.06269393850386 2.50212448761315 -1.23542741649745 0.00371839499686727 0.018186265438479 DOWN ENSG00000272498 RP11-415F23.3 - - - - - - - 3:16339308-16339871 0 0 1 4 3 7 0 0 0.11302247840398 0.449509592956275 0.308743903198802 0.822820451053951 0.0376741594679933 0.527024649069676 -3.80622320868997 0.00375561328337484 0.0183472555984082 DOWN ENSG00000170442 KRT86 keratin 86, type II [Source:HGNC Symbol;Acc:HGNC:6463] GO:0005198|GO:0005623|GO:0005576|GO:0005488|GO:1903561|GO:0043229|GO:0043227|GO:0005615|GO:0005622|GO:0005515|GO:0031982|GO:0005882|GO:0070062|GO:0045095|GO:0005856|GO:0045111 structural molecule activity|cell|extracellular region|binding|extracellular vesicle|intracellular organelle|membrane-bounded organelle|extracellular space|intracellular|protein binding|vesicle|intermediate filament|extracellular exosome|keratin filament|cytoskeleton|intermediate filament cytoskeleton - - - - 12:52249300-52309163 22 19 17 8 9 9 0.550479181396721 0.432079647739721 0.38351379899797 0.179358620748029 0.184767089799589 0.211051370764013 0.455357542711471 0.191725693770544 1.2479560915305 0.00377129383430616 0.0184148194519752 UP ENSG00000134531 EMP1 epithelial membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:3333] GO:0032502|GO:0040007|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0008283|GO:0016049|GO:0016043|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0009888|GO:0007275|GO:0022607|GO:0008219|GO:0030030|GO:0016021|GO:0030031|GO:0060429|GO:0008544|GO:0032060 developmental process|growth|cell|membrane|cellular process|binding|cell proliferation|cell growth|cellular component organization|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|tissue development|multicellular organism development|cellular component assembly|cell death|cell projection organization|integral component of membrane|cell projection assembly|epithelium development|epidermis development|bleb assembly - - - - 12:13196716-13219939 377 873 700 2165 2440 505 2.17927425504722 4.58632883786886 3.64823908439045 11.2131157410659 11.5725367039914 2.73584476757144 3.47128072576884 8.50716573754291 -1.29321051911421 0.00377832634220849 0.0184401102861357 DOWN ENSG00000270194 RP11-259K5.2 - - - - - - - 3:37241789-37244177 28 28 17 14 10 9 0.829052332983474 0.753471937301777 0.453827337700821 0.371424000207487 0.242946751966426 0.24974559445369 0.678783869328691 0.288038782209201 1.23668920842399 0.00377780239753077 0.0184401102861357 UP ENSG00000124215 CDH26 cadherin 26 [Source:HGNC Symbol;Acc:HGNC:15902] GO:0005623|GO:0016020|GO:0005488|GO:0043167|GO:0007155|GO:0071944|GO:0031224|GO:0005886|GO:0098609|GO:0043169|GO:0016021|GO:0098742|GO:0046872|GO:0005509|GO:0007156 cell|membrane|binding|ion binding|cell adhesion|cell periphery|intrinsic component of membrane|plasma membrane|cell-cell adhesion|cation binding|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|metal ion binding|calcium ion binding|homophilic cell adhesion via plasma membrane adhesion molecules - - - - 20:59958427-60034011 13 11 16 27 31 41 0.103765453486865 0.0798003551712519 0.115148818770866 0.193099860221001 0.203024653303858 0.306710465384614 0.0995715424763276 0.234278326303158 -1.23441810849816 0.00378441382116915 0.0184668012777352 DOWN ENSG00000260052 CTC-527H23.3 - - - - - - - 16:48637143-48638719 14 9 17 5 5 5 1.83735833436588 1.07349933834786 2.01149074168323 0.587889061091189 0.538404258300363 0.615026426046368 1.64078280479899 0.580439915145973 1.49916563992006 0.00379548079989368 0.0185147522549062 UP ENSG00000234997 AC016745.3 - - - - - - - 2:113424495-113425324 0 1 2 5 6 8 0 0.126609698301062 0.251094692900447 0.623764180960927 0.685442916258494 1.04400881844911 0.125901463733836 0.784405305222844 -2.63930423707641 0.00379820577272049 0.0185219920187516 DOWN ENSG00000144410 CPO carboxypeptidase O [Source:HGNC Symbol;Acc:HGNC:21011] GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0043167|GO:0016787|GO:0005615|GO:0043169|GO:0008233|GO:0019538|GO:0046872|GO:0006508|GO:0008237|GO:0008238|GO:0046914|GO:0004180|GO:0008235|GO:0008270|GO:0004181 extracellular region|metabolic process|binding|catalytic activity|organic substance metabolic process|ion binding|hydrolase activity|extracellular space|cation binding|peptidase activity|protein metabolic process|metal ion binding|proteolysis|metallopeptidase activity|exopeptidase activity|transition metal ion binding|carboxypeptidase activity|metalloexopeptidase activity|zinc ion binding|metallocarboxypeptidase activity - - - - 2:206939554-206969474 0 0 0 7 1 3 0 0 0 0.366942852888189 0.0480258292674545 0.164480757761087 0 0.193149813305577 -Inf 0.00380251868799075 0.0185399955759066 DOWN ENSG00000230289 RP11-334J6.6 - - - - - - - 9:131516558-131522229 4 8 5 1 1 1 0.598169665523595 1.08731166307094 0.674116037646297 0.133929795984803 0.122755238021887 0.140138996570229 0.786532455413611 0.132274676858973 2.57196940481326 0.00380383424391711 0.0185433813713098 UP ENSG00000262497 FAM187B2P family with sequence similarity 187 member B2, pseudogene [Source:HGNC Symbol;Acc:HGNC:49213] - - - - - - 19:35232291-35233003 5 4 5 0 1 1 0.496074256963919 0.360658076179913 0.447204608424542 0 0.0814351018013358 0.092967384821484 0.434645647189458 0.0581341622076066 2.90238158722306 0.00381008247127786 0.0185677770319179 UP ENSG00000260190 RP11-229P13.25 - - - - - - - 9:136937169-136937988 5 8 1 0 1 0 0.431342616116188 0.627193191015312 0.0777374119754201 0 0.0708088141272591 0 0.378757739702307 0.0236029380424197 4.00423701013171 0.00383050991801318 0.0186521029346543 UP ENSG00000197496 SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10 [Source:HGNC Symbol;Acc:HGNC:13444] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0071944|GO:0031224|GO:0005622|GO:0005886|GO:0012505|GO:0006810|GO:0005887|GO:0005737|GO:0022891|GO:0031226|GO:0055085|GO:0016021|GO:0006811|GO:0015075|GO:0051119|GO:0048471|GO:0034219|GO:0008643|GO:0015293|GO:0015992|GO:0006812|GO:0035428|GO:0008324|GO:0015149|GO:0008645|GO:1904659|GO:0005351|GO:0015672|GO:0005355|GO:0015295|GO:0015758|GO:0046323 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|cell periphery|intrinsic component of membrane|intracellular|plasma membrane|endomembrane system|transport|integral component of plasma membrane|cytoplasm|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|integral component of membrane|ion transport|ion transmembrane transporter activity|sugar transmembrane transporter activity|perinuclear region of cytoplasm|carbohydrate transmembrane transport|carbohydrate transport|symporter activity|proton transport|cation transport|hexose transmembrane transport|cation transmembrane transporter activity|hexose transmembrane transporter activity|hexose transport|glucose transmembrane transport|sugar:proton symporter activity|monovalent inorganic cation transport|glucose transmembrane transporter activity|solute:proton symporter activity|glucose transport|glucose import - - - - 20:46709487-46736347 96 126 232 245 244 532 1.24100024630269 1.48029971892594 2.70396702725057 2.83767614836844 2.5879614014883 6.44525933775975 1.8084223308264 3.9569656292055 -1.12966289628152 0.00384116996770876 0.0186918155201267 DOWN ENSG00000250609 RP11-158C21.2 - - - - - - - 4:154523487-154524807 3 5 1 0 0 0 0.207665185243585 0.314546903183187 0.0623724831896717 0 0 0 0.194861523872148 0 Inf 0.00384241422749125 0.0186948230683709 UP ENSG00000205267 DGAT2L7P diacylglycerol O-acyltransferase 2-like 7, pseudogene [Source:HGNC Symbol;Acc:HGNC:44367] - - - - - - 7:101201809-101203526 3 5 1 0 0 0 0.28526050983729 0.432079213781206 0.0856783304030168 0 0 0 0.267672684673838 0 Inf 0.00384340919684232 0.0186966169402853 UP ENSG00000279636 LINC00216 long intergenic non-protein coding RNA 216 [Source:HGNC Symbol;Acc:HGNC:20191] - - - - - - 14:58288033-58289158 1 2 6 11 16 8 0.0315781764491807 0.0573737635690044 0.170757836671254 0.311092065849692 0.414370723742573 0.236660633544019 0.0865699255631464 0.320707807712095 -1.88932165288059 0.00386162313870346 0.0187699279034277 DOWN ENSG00000260941 LINC00622 long intergenic non-protein coding RNA 622 [Source:HGNC Symbol;Acc:HGNC:44251] - - - - - - 1:119597702-119599271 19 34 47 8 16 21 0.856032373560245 1.39220908961042 1.90921549128339 0.322959758506164 0.591468020322998 0.886714449957251 1.38581898481802 0.600380742928804 1.20678921676012 0.00388581339107013 0.0188721446196531 UP ENSG00000138115 CYP2C8 cytochrome P450 family 2 subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:2622] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0044255|GO:0006082|GO:0009410|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0070988|GO:0042493|GO:0004497|GO:0006629|GO:0005783|GO:0006805|GO:0017144|GO:0055114|GO:0042737|GO:0070989|GO:0046872|GO:0020037|GO:0042738|GO:0006631|GO:0008395|GO:0071466|GO:0016712|GO:0006690|GO:0033559|GO:0070330|GO:0008392|GO:0001676|GO:0019369|GO:0034875|GO:0046914|GO:0019752|GO:0097267|GO:0005506|GO:0019373|GO:0032787 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular lipid metabolic process|organic acid metabolic process|response to xenobiotic stimulus|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|demethylation|response to drug|monooxygenase activity|lipid metabolic process|endoplasmic reticulum|xenobiotic metabolic process|drug metabolic process|oxidation-reduction process|drug catabolic process|oxidative demethylation|metal ion binding|heme binding|exogenous drug catabolic process|fatty acid metabolic process|steroid hydroxylase activity|cellular response to xenobiotic stimulus|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|icosanoid metabolic process|unsaturated fatty acid metabolic process|aromatase activity|arachidonic acid epoxygenase activity|long-chain fatty acid metabolic process|arachidonic acid metabolic process|caffeine oxidase activity|transition metal ion binding|carboxylic acid metabolic process|omega-hydroxylase P450 pathway|iron ion binding|epoxygenase P450 pathway|monocarboxylic acid metabolic process K17718 cytochrome P450, family 2, subfamily C, polypeptide 8[1.14.14.1] hsa01100|hsa04726|hsa05204|hsa00982|hsa00830|hsa00590|hsa00591 Metabolic pathways - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human)|Linoleic acid metabolism - Homo sapiens (human) 10:95036772-95069497 0 0 0 3 4 2 0 0 0 0.0301379991620928 0.0368003594862941 0.0210164062706779 0 0.0293182549730216 -Inf 0.00392383084129029 0.0190351065869159 DOWN ENSG00000171189 GRIK1 glutamate receptor, ionotropic, kainate 1 [Source:HGNC Symbol;Acc:HGNC:4579] GO:0032502|GO:0004871|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0051716|GO:0004872|GO:0022857|GO:0050794|GO:0038023|GO:0023051|GO:0071944|GO:0031224|GO:0005886|GO:0048856|GO:0097060|GO:0050804|GO:0030594|GO:0006810|GO:0007275|GO:0045211|GO:0005887|GO:0004888|GO:0007267|GO:0022891|GO:0010646|GO:0031226|GO:0007154|GO:0055085|GO:0007165|GO:0016021|GO:0007166|GO:0007417|GO:0015267|GO:0006811|GO:0015075|GO:0051966|GO:0008066|GO:0007399|GO:0034220|GO:0015276|GO:0005216|GO:0022824|GO:0007215|GO:0004970|GO:0015277|GO:0035235|GO:0005230|GO:0007268|GO:0005231|GO:0007270|GO:0005234|GO:0035249 developmental process|signal transducer activity|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|cellular response to stimulus|receptor activity|transmembrane transporter activity|regulation of cellular process|signaling receptor activity|regulation of signaling|cell periphery|intrinsic component of membrane|plasma membrane|anatomical structure development|synaptic membrane|modulation of synaptic transmission|neurotransmitter receptor activity|transport|multicellular organism development|postsynaptic membrane|integral component of plasma membrane|transmembrane signaling receptor activity|cell-cell signaling|substrate-specific transmembrane transporter activity|regulation of cell communication|intrinsic component of plasma membrane|cell communication|transmembrane transport|signal transduction|integral component of membrane|cell surface receptor signaling pathway|central nervous system development|channel activity|ion transport|ion transmembrane transporter activity|regulation of synaptic transmission, glutamatergic|glutamate receptor activity|nervous system development|ion transmembrane transport|ligand-gated ion channel activity|ion channel activity|transmitter-gated ion channel activity|glutamate receptor signaling pathway|ionotropic glutamate receptor activity|kainate selective glutamate receptor activity|ionotropic glutamate receptor signaling pathway|extracellular ligand-gated ion channel activity|synaptic transmission|excitatory extracellular ligand-gated ion channel activity|neuron-neuron synaptic transmission|extracellular-glutamate-gated ion channel activity|synaptic transmission, glutamatergic K05201 glutamate receptor, ionotropic kainate 1[-] hsa04080|hsa04724 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human) 21:29536933-29940033 0 0 0 2 4 3 0 0 0 0.0181815411953054 0.0332955633447423 0.0285222656530629 0 0.0266664567310369 -Inf 0.00392383084129029 0.0190351065869159 DOWN ENSG00000172410 INSL5 insulin like 5 [Source:HGNC Symbol;Acc:HGNC:6088] GO:0005576|GO:0005488|GO:0005515|GO:0005102|GO:0005179 extracellular region|binding|protein binding|receptor binding|hormone activity - - - - 1:66797741-66801256 3 3 3 0 0 0 0.296830516529992 0.26977948376934 0.267553540997583 0 0 0 0.278054513765638 0 Inf 0.00392383084129029 0.0190351065869159 UP ENSG00000116690 PRG4 proteoglycan 4 [Source:HGNC Symbol;Acc:HGNC:9364] GO:0002376|GO:0050896|GO:0005488|GO:0004872|GO:0008283|GO:0006955|GO:0030246|GO:0006810|GO:0030247|GO:0038024|GO:0016192|GO:0005044|GO:0006897|GO:0006898 immune system process|response to stimulus|binding|receptor activity|cell proliferation|immune response|carbohydrate binding|transport|polysaccharide binding|cargo receptor activity|vesicle-mediated transport|scavenger receptor activity|endocytosis|receptor-mediated endocytosis - - - - 1:186296279-186314562 7 6 14 2 2 4 0.0654118984295382 0.0509542684906759 0.117951483217172 0.0167452714945402 0.0153326728956105 0.035025492934065 0.0781058833791287 0.0223678124414052 1.80400705586248 0.00393590502702207 0.0190812777974532 UP ENSG00000254912 RP11-632K20.2 - - - - - - - 15:32494003-32500346 7 3 5 0 2 0 0.403889128149759 0.15733469077902 0.260079025943474 0 0.0946723766882313 0 0.273767614957418 0.0315574588960771 3.11689884976012 0.00394414262370653 0.0191150055013206 UP ENSG00000270617 URGCP-MRPS24 URGCP-MRPS24 readthrough [Source:HGNC Symbol;Acc:HGNC:49188] - - - - - - 7:43866558-43906589 9 8 5 0 5 0 0.800798989947087 0.646916247336548 0.401077843782011 0 0.365031314747039 0 0.616264360355215 0.12167710491568 2.34049162765214 0.00395550422378299 0.0191638466564131 UP ENSG00000103742 IGDCC4 immunoglobulin superfamily, DCC subclass, member 4 [Source:HGNC Symbol;Acc:HGNC:13770] GO:0005623|GO:0016020|GO:0005488|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0016021 cell|membrane|binding|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|integral component of membrane - - - - 15:65381464-65423072 12 29 14 3 9 8 0.0706272582017538 0.155117912051825 0.0742901013357176 0.0158174971889909 0.0434592364475779 0.0441265063459644 0.100011757196432 0.0344677466608444 1.53685072023465 0.00396112234465346 0.0191848388185082 UP ENSG00000214872 SMTNL1 smoothelin-like 1 [Source:HGNC Symbol;Acc:HGNC:32394] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0009892|GO:0014823|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0030017|GO:0006725|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0046483|GO:0061061|GO:0043231|GO:0019899|GO:0005737|GO:0009887|GO:0031430|GO:1903524|GO:0031672|GO:0009890|GO:0031674|GO:0042493|GO:0006139|GO:0005516|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0003013|GO:0035150|GO:0010468|GO:0034645|GO:0043412|GO:0010629|GO:0051252|GO:0036211|GO:0045907|GO:0019902|GO:0043292|GO:0006796|GO:0044267|GO:0010467|GO:0009059|GO:0007517|GO:0016070|GO:0008015|GO:0005634|GO:0045908|GO:0048644|GO:0030016|GO:0042312|GO:0045892|GO:0032774|GO:2001141|GO:0016310|GO:1902679|GO:0019229|GO:0019903|GO:0006464|GO:0006351|GO:0006355|GO:0050880|GO:1903507|GO:0006468|GO:1903506|GO:0042311|GO:0008157|GO:0042310|GO:0018193|GO:0018105 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|negative regulation of metabolic process|response to activity|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|anatomical structure development|regulation of metabolic process|sarcomere|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|organ morphogenesis|M band|positive regulation of blood circulation|A band|negative regulation of biosynthetic process|I band|response to drug|nucleobase-containing compound metabolic process|calmodulin binding|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|regulation of tube size|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|negative regulation of gene expression|regulation of RNA metabolic process|protein modification process|positive regulation of vasoconstriction|phosphatase binding|contractile fiber|phosphate-containing compound metabolic process|cellular protein metabolic process|gene expression|macromolecule biosynthetic process|muscle organ development|RNA metabolic process|blood circulation|nucleus|negative regulation of vasodilation|muscle organ morphogenesis|myofibril|regulation of vasodilation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|phosphorylation|negative regulation of RNA biosynthetic process|regulation of vasoconstriction|protein phosphatase binding|cellular protein modification process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of blood vessel size|negative regulation of nucleic acid-templated transcription|protein phosphorylation|regulation of nucleic acid-templated transcription|vasodilation|protein phosphatase 1 binding|vasoconstriction|peptidyl-amino acid modification|peptidyl-serine phosphorylation - - - - 11:57542641-57550274 7 7 13 1 2 5 0.218135714146081 0.198256184674606 0.365234053647756 0.0279069574893445 0.0511314245902078 0.146034909092067 0.260541984156148 0.0750244303905398 1.79608350387003 0.00397459464965425 0.019243845064998 UP ENSG00000226544 RPL7P22 ribosomal protein L7 pseudogene 22 [Source:HGNC Symbol;Acc:HGNC:35802] - - - - - - 5:72725419-72726151 104 120 55 58 53 35 10.0363190332246 10.5245242148545 4.78539254746062 5.01495390828421 4.19647240238092 3.16546133045258 8.44874526517991 4.1256292137059 1.03412293421794 0.00397527780030785 0.0192440316929448 UP ENSG00000064989 CALCRL calcitonin receptor like receptor [Source:HGNC Symbol;Acc:HGNC:16709] GO:0032502|GO:0004871|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0044237|GO:0038023|GO:0009653|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0048514|GO:0007507|GO:0008284|GO:0042127|GO:0006725|GO:0008565|GO:0006810|GO:0031623|GO:1901360|GO:0001568|GO:0007275|GO:0048513|GO:0034641|GO:0044281|GO:0006952|GO:0019637|GO:0031325|GO:0046483|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0003012|GO:0009611|GO:0045184|GO:0006139|GO:0031226|GO:0001525|GO:0055086|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0045932|GO:0016021|GO:0044249|GO:0010033|GO:0031323|GO:0005768|GO:0016192|GO:0009743|GO:0007186|GO:0006936|GO:0048660|GO:0007166|GO:0001944|GO:0072358|GO:0050727|GO:0019693|GO:0015031|GO:0048659|GO:0005773|GO:0090257|GO:0048661|GO:0006811|GO:0006954|GO:0050728|GO:0006796|GO:1901137|GO:0051174|GO:0071310|GO:0031328|GO:0045986|GO:0008528|GO:0072359|GO:0004930|GO:0043112|GO:0071322|GO:0007187|GO:0006939|GO:0006937|GO:0009259|GO:0000323|GO:0009117|GO:0046390|GO:0006812|GO:0006163|GO:0006897|GO:0009165|GO:0006164|GO:0030801|GO:0007188|GO:0006940|GO:0005764|GO:0001635|GO:0009744|GO:0001605|GO:0006898|GO:0009187|GO:0030001|GO:0030802|GO:0009190|GO:0004948|GO:0046058|GO:0007189|GO:0030819|GO:0009152|GO:0030817|GO:0052652|GO:0030814|GO:0030816|GO:0071329|GO:0006171|GO:0006816 developmental process|signal transducer activity|transporter activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|cellular metabolic process|signaling receptor activity|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|blood vessel morphogenesis|heart development|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|protein transporter activity|transport|receptor internalization|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|small molecule metabolic process|defense response|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|muscle system process|response to wounding|establishment of protein localization|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|angiogenesis|nucleobase-containing small molecule metabolic process|protein localization|cell communication|signal transduction|endoplasmic reticulum|negative regulation of muscle contraction|integral component of membrane|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|endosome|vesicle-mediated transport|response to carbohydrate|G-protein coupled receptor signaling pathway|muscle contraction|regulation of smooth muscle cell proliferation|cell surface receptor signaling pathway|vasculature development|cardiovascular system development|regulation of inflammatory response|ribose phosphate metabolic process|protein transport|smooth muscle cell proliferation|vacuole|regulation of muscle system process|positive regulation of smooth muscle cell proliferation|ion transport|inflammatory response|negative regulation of inflammatory response|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|regulation of phosphorus metabolic process|cellular response to organic substance|positive regulation of cellular biosynthetic process|negative regulation of smooth muscle contraction|G-protein coupled peptide receptor activity|circulatory system development|G-protein coupled receptor activity|receptor metabolic process|cellular response to carbohydrate stimulus|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|smooth muscle contraction|regulation of muscle contraction|ribonucleotide metabolic process|lytic vacuole|nucleotide metabolic process|ribose phosphate biosynthetic process|cation transport|purine nucleotide metabolic process|endocytosis|nucleotide biosynthetic process|purine nucleotide biosynthetic process|positive regulation of cyclic nucleotide metabolic process|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|regulation of smooth muscle contraction|lysosome|calcitonin gene-related peptide receptor activity|response to sucrose|adrenomedullin receptor activity|receptor-mediated endocytosis|cyclic nucleotide metabolic process|metal ion transport|regulation of cyclic nucleotide biosynthetic process|cyclic nucleotide biosynthetic process|calcitonin receptor activity|cAMP metabolic process|adenylate cyclase-activating G-protein coupled receptor signaling pathway|positive regulation of cAMP biosynthetic process|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|regulation of cAMP metabolic process|positive regulation of cAMP metabolic process|cellular response to sucrose stimulus|cAMP biosynthetic process|calcium ion transport K04577 calcitonin receptor-like[-] hsa04080|hsa04270 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Vascular smooth muscle contraction - Homo sapiens (human) 2:187343129-187448460 1 0 1 5 5 6 0.00913826103081274 0 0.00823149248706669 0.0409184147634492 0.0374741600237469 0.0513668632511248 0.00578991783929314 0.0432531460127736 -2.90119028964132 0.00399179466988131 0.0193114629840604 DOWN ENSG00000228577 AC010731.2 - - - - - - - 2:206606497-206609812 0 0 0 2 3 4 0 0 0 0.288094784576521 0.395753548645737 0.602597685251983 0 0.428815339491414 -Inf 0.00401729883807809 0.019425403225135 DOWN ENSG00000172247 C1QTNF4 C1q and tumor necrosis factor related protein 4 [Source:HGNC Symbol;Acc:HGNC:14346] GO:0005576|GO:0005488|GO:0005615|GO:0005515|GO:0005102|GO:0005125 extracellular region|binding|extracellular space|protein binding|receptor binding|cytokine activity - - - - 11:47589664-47594659 13 10 8 2 2 6 0.419129192707655 0.293014138920098 0.23255442842922 0.057776529267853 0.052902613409194 0.181305829086924 0.314899253352324 0.0973283239213237 1.69395872082876 0.0040202066286759 0.0194331685059084 UP ENSG00000120215 MLANA melan-A [Source:HGNC Symbol;Acc:HGNC:7124] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0042175|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0031982|GO:0005887|GO:0043231|GO:0005737|GO:0031226|GO:0005783|GO:0016021|GO:0005794|GO:0005802|GO:0031410|GO:0016023|GO:0031988|GO:0042470 cell|membrane|binding|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|organelle membrane|vesicle|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|intrinsic component of plasma membrane|endoplasmic reticulum|integral component of membrane|Golgi apparatus|trans-Golgi network|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|melanosome - - - - 9:5890802-5910606 2 1 1 8 7 6 0.0319194778646954 0.0145121224586957 0.0143828244178349 0.114405871131471 0.0916670191885531 0.0897529307348173 0.020271474913742 0.0986086070182805 -2.28226251688323 0.0040379177482008 0.0195054409512497 DOWN ENSG00000227471 AKR1B15 aldo-keto reductase family 1, member B15 [Source:HGNC Symbol;Acc:HGNC:37281] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0016491|GO:0043229|GO:0071704|GO:0044237|GO:0042445|GO:0043227|GO:0009058|GO:0005622|GO:1901360|GO:0044281|GO:0016614|GO:0043231|GO:0005737|GO:0016229|GO:0008210|GO:0006629|GO:0042446|GO:0010817|GO:0044249|GO:0055114|GO:0005829|GO:0006703|GO:0016616|GO:0005759|GO:0005739|GO:0008202|GO:0008610|GO:0004303|GO:0006694 cell|cellular process|metabolic process|catalytic activity|oxidoreductase activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|organic cyclic compound metabolic process|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cytoplasm|steroid dehydrogenase activity|estrogen metabolic process|lipid metabolic process|hormone biosynthetic process|regulation of hormone levels|cellular biosynthetic process|oxidation-reduction process|cytosol|estrogen biosynthetic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|mitochondrial matrix|mitochondrion|steroid metabolic process|lipid biosynthetic process|estradiol 17-beta-dehydrogenase activity|steroid biosynthetic process - - - - 7:134549136-134579875 20 23 47 73 51 82 0.389198767513672 0.40677809421636 0.824613018243447 1.27280383625002 0.814290491643863 1.49549829119034 0.540196626657826 1.19419753969474 -1.14448496571242 0.00403842468411852 0.0195054409512497 DOWN ENSG00000225400 RAB28P5 RAB28, member RAS oncogene family pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:51547] - - - - - - X:136847384-136848034 14 16 13 6 5 6 1.52125367469003 1.58002585755009 1.27355038675946 0.584155323565297 0.445775568700301 0.611036849488034 1.45827663966653 0.546989247251211 1.41468005159569 0.0040455905453787 0.0195283039484223 UP ENSG00000226647 RP11-336A10.2 - - - - - - - 10:5712174-5744067 1 0 2 4 8 7 0.0420979734816263 0 0.0758810850645015 0.150817019885389 0.27622335313981 0.276068253655222 0.0393263528487093 0.234369542226807 -2.57521679365813 0.00404461183624684 0.0195283039484223 DOWN ENSG00000260855 RP11-439E19.10 - - - - - - - 1:246772301-246775772 2 0 2 4 7 12 0.0407451399470997 0 0.0367385092146967 0.0730194154456621 0.117012738779858 0.229118508434049 0.0258278830539321 0.13971688755319 -2.4355051046108 0.00406470321713472 0.019616496903385 DOWN ENSG00000272716 RP11-563N4.1 - - - - - - - 2:32165046-32165757 25 15 20 10 8 9 2.48376188922398 1.35441005034257 1.79151831451442 0.890180514140937 0.652150922230365 0.837980653300372 1.87656341802699 0.793437363223891 1.24190480541932 0.00406733817961557 0.0196260407328662 UP ENSG00000184261 KCNK12 potassium channel, two pore domain subfamily K, member 12 [Source:HGNC Symbol;Acc:HGNC:6274] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0050794|GO:0071944|GO:0031224|GO:0005886|GO:0042391|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:0055085|GO:0071804|GO:0016021|GO:0030322|GO:0015267|GO:0006811|GO:0015075|GO:0034765|GO:0043269|GO:0071805|GO:0034220|GO:0098655|GO:0005216|GO:0006812|GO:0008324|GO:0022840|GO:0005244|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0006813|GO:0015077|GO:0022841|GO:0046873|GO:0005267|GO:0015079 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|regulation of cellular process|cell periphery|intrinsic component of membrane|plasma membrane|regulation of membrane potential|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transport|cellular potassium ion transport|integral component of membrane|stabilization of membrane potential|channel activity|ion transport|ion transmembrane transporter activity|regulation of ion transmembrane transport|regulation of ion transport|potassium ion transmembrane transport|ion transmembrane transport|cation transmembrane transport|ion channel activity|cation transport|cation transmembrane transporter activity|leak channel activity|voltage-gated ion channel activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|potassium ion transport|monovalent inorganic cation transmembrane transporter activity|potassium ion leak channel activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity - - - - 2:47516581-47570939 4 6 2 0 1 0 0.0400756730584505 0.0546351009170562 0.0180674368262645 0 0.00822425319891678 0 0.0375927369339237 0.00274141773297226 3.77745986875953 0.00409482626701338 0.019739535503862 UP ENSG00000109667 SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 [Source:HGNC Symbol;Acc:HGNC:13446] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0022857|GO:0006807|GO:0071704|GO:0044237|GO:0045177|GO:0071944|GO:0031224|GO:0005886|GO:0006725|GO:0016323|GO:0006810|GO:1901360|GO:0006082|GO:0016324|GO:0034641|GO:0044281|GO:0046483|GO:0022891|GO:0055085|GO:0016021|GO:0046415|GO:0006811|GO:0015075|GO:0051119|GO:0034219|GO:0008643|GO:0015293|GO:0015992|GO:0006812|GO:0035428|GO:0008324|GO:0015149|GO:0008645|GO:1904659|GO:0005351|GO:0015672|GO:0005355|GO:0015295|GO:0015758 transporter activity|cell|membrane|cellular process|metabolic process|transmembrane transporter activity|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|apical part of cell|cell periphery|intrinsic component of membrane|plasma membrane|cellular aromatic compound metabolic process|basolateral plasma membrane|transport|organic cyclic compound metabolic process|organic acid metabolic process|apical plasma membrane|cellular nitrogen compound metabolic process|small molecule metabolic process|heterocycle metabolic process|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|urate metabolic process|ion transport|ion transmembrane transporter activity|sugar transmembrane transporter activity|carbohydrate transmembrane transport|carbohydrate transport|symporter activity|proton transport|cation transport|hexose transmembrane transport|cation transmembrane transporter activity|hexose transmembrane transporter activity|hexose transport|glucose transmembrane transport|sugar:proton symporter activity|monovalent inorganic cation transport|glucose transmembrane transporter activity|solute:proton symporter activity|glucose transport - - - - 4:9771153-10054936 5 9 6 0 4 1 0.043452204571901 0.0710830642960068 0.0470108491376267 0 0.028518018137536 0.00814321196286463 0.0538487060018448 0.0122204100334669 2.13961898389843 0.00409652891250727 0.0197445550781389 UP ENSG00000233850 AC103563.8 - - - - - - - 2:95025193-95026709 3 5 9 14 22 17 0.444003806106577 0.67252496873058 1.20077216274802 1.8563429633801 2.67127178810744 2.35773787640588 0.772433645861726 2.29511754263114 -1.57108512996918 0.00410167686830425 0.0197661761463043 DOWN ENSG00000235513 RP4-756G23.5 - - - - - - - 22:41209122-41217627 8 12 10 2 4 4 0.172520885239427 0.235197446630742 0.194445280477785 0.0386468613456309 0.0707733742803485 0.0808362748508757 0.200721204115985 0.0634188368256184 1.66220970842634 0.00410523852304727 0.0197801470088853 UP ENSG00000213252 RP11-819M15.1 - - - - - - - 11:106826392-106827890 9 11 6 26 23 22 0.424706602406894 0.471775015028442 0.255282396251021 1.09929156075094 0.890509019980503 0.972980619453638 0.383921337895452 0.987593733395027 -1.36310693643511 0.00412285873227688 0.0198490283169479 DOWN ENSG00000232380 ZDHHC20P4 zinc finger, DHHC-type containing 20 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:39776] - - - - - - 13:68985058-68986064 2 3 3 7 16 11 0.140483739718302 0.191551470600872 0.18997098491884 0.440550058730705 0.922149743701198 0.72414470298441 0.174002065079338 0.695614835138771 -1.99918427256479 0.0041238754109121 0.0198507217860964 DOWN ENSG00000271816 BMS1P4 BMS1, ribosome biogenesis factor pseudogene 4 [Source:EntrezGene;Acc:729096] - - - - - - 10:73699151-73730487 20 31 6 55 39 91 0.73953869310622 1.04178608944539 0.200035709346723 1.82219065136322 1.1832084750956 3.15356953143062 0.660453497299444 2.05298955262981 -1.63619739616452 0.00412747266676357 0.0198648345951249 DOWN ENSG00000184988 TMEM106A transmembrane protein 106A [Source:HGNC Symbol;Acc:HGNC:28288] GO:0016020|GO:0005576|GO:1903561|GO:0043227|GO:0031224|GO:0031982|GO:0070062|GO:0016021 membrane|extracellular region|extracellular vesicle|membrane-bounded organelle|intrinsic component of membrane|vesicle|extracellular exosome|integral component of membrane - - - - 17:43211835-43220041 11 10 13 34 18 41 0.123704661828977 0.102205567693274 0.131809427946011 0.342589009605777 0.16608475766723 0.432125301150787 0.119239885822754 0.313599689474598 -1.39505723190113 0.00413187952486971 0.0198796343812184 DOWN ENSG00000271714 CTD-2377O17.1 - - - - - - - 5:74865893-74867854 0 0 0 3 2 4 0 0 0 0.0968962786516215 0.0591581721813311 0.135139134307274 0 0.0970645283800755 -Inf 0.00414000921701444 0.019909122932466 DOWN ENSG00000278987 LA16c-431H6.7 - - - - - - - 16:1688355-1690536 3 8 16 13 30 47 0.0972657283771512 0.235700465917762 0.467666742414031 0.377598086518253 0.797956576532741 1.42798035437908 0.266877645569648 0.867845005810025 -1.70125893890655 0.00414282392497662 0.0199194500654295 DOWN ENSG00000163093 BBS5 Bardet-Biedl syndrome 5 [Source:HGNC Symbol;Acc:HGNC:970] GO:0032502|GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0042995|GO:0043229|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0043473|GO:0043227|GO:0008289|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0005929|GO:0048646|GO:0031090|GO:0007507|GO:0035239|GO:0051640|GO:0009888|GO:0006810|GO:0035295|GO:0007275|GO:0048513|GO:0050877|GO:0043168|GO:0060170|GO:0005543|GO:0022607|GO:0005737|GO:0007389|GO:0009887|GO:0051656|GO:0048729|GO:0048598|GO:0048568|GO:0045184|GO:0036064|GO:0033059|GO:0008104|GO:0051649|GO:0008134|GO:0030030|GO:0031253|GO:0048869|GO:0034464|GO:0006996|GO:0051650|GO:0000902|GO:0005829|GO:0003143|GO:0002009|GO:0072358|GO:0001085|GO:0035091|GO:0035050|GO:0005815|GO:0070491|GO:0003007|GO:0051904|GO:0051875|GO:0015031|GO:0009790|GO:0044782|GO:0046907|GO:0007600|GO:0030031|GO:0061371|GO:0070925|GO:0060429|GO:0042384|GO:0032990|GO:0048562|GO:0060562|GO:0051648|GO:0048858|GO:0072359|GO:0005856|GO:0060271|GO:0050953|GO:0032400|GO:0032402|GO:0001947|GO:0015630|GO:1901981|GO:0009855|GO:0001103|GO:0044458|GO:0032401|GO:0007368|GO:0032266|GO:0007601 developmental process|macromolecular complex|cell|membrane|cellular process|response to stimulus|binding|cell projection|intracellular organelle|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|pigmentation|membrane-bounded organelle|lipid binding|cell periphery|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|cilium|anatomical structure formation involved in morphogenesis|organelle membrane|heart development|tube morphogenesis|organelle localization|tissue development|transport|tube development|multicellular organism development|animal organ development|neurological system process|anion binding|ciliary membrane|phospholipid binding|cellular component assembly|cytoplasm|pattern specification process|organ morphogenesis|establishment of organelle localization|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|establishment of protein localization|ciliary basal body|cellular pigmentation|protein localization|establishment of localization in cell|transcription factor binding|cell projection organization|cell projection membrane|cellular developmental process|BBSome|organelle organization|establishment of vesicle localization|cell morphogenesis|cytosol|embryonic heart tube morphogenesis|morphogenesis of an epithelium|cardiovascular system development|RNA polymerase II transcription factor binding|phosphatidylinositol binding|embryonic heart tube development|microtubule organizing center|repressing transcription factor binding|heart morphogenesis|pigment granule transport|pigment granule localization|protein transport|embryo development|cilium organization|intracellular transport|sensory perception|cell projection assembly|determination of heart left/right asymmetry|organelle assembly|epithelium development|cilium assembly|cell part morphogenesis|embryonic organ morphogenesis|epithelial tube morphogenesis|vesicle localization|cell projection morphogenesis|circulatory system development|cytoskeleton|cilium morphogenesis|sensory perception of light stimulus|melanosome localization|melanosome transport|heart looping|microtubule cytoskeleton|phosphatidylinositol phosphate binding|determination of bilateral symmetry|RNA polymerase II repressing transcription factor binding|motile cilium assembly|establishment of melanosome localization|determination of left/right symmetry|phosphatidylinositol-3-phosphate binding|visual perception - - - - 2:169479178-169506655 15 15 25 37 47 41 0.141452682935199 0.128561519243289 0.212560715336751 0.31262436596918 0.363659414676163 0.362360771128976 0.160858305838413 0.34621485059144 -1.10587717845508 0.00414665815488522 0.019931465554008 DOWN ENSG00000127325 BEST3 bestrophin 3 [Source:HGNC Symbol;Acc:HGNC:17105] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0051051|GO:0071944|GO:0031224|GO:0005886|GO:0043234|GO:0006810|GO:0005887|GO:0022891|GO:0031226|GO:1902495|GO:0055085|GO:0016021|GO:0043271|GO:0015267|GO:0006811|GO:0015075|GO:0034702|GO:0043269|GO:0034220|GO:0006820|GO:0005216|GO:0098656|GO:0034707|GO:0008509|GO:0005253|GO:0015698|GO:0005254|GO:1902476|GO:0006821|GO:0015108 macromolecular complex|transporter activity|cell|membrane|cellular process|transmembrane transporter activity|negative regulation of transport|cell periphery|intrinsic component of membrane|plasma membrane|protein complex|transport|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|transmembrane transport|integral component of membrane|negative regulation of ion transport|channel activity|ion transport|ion transmembrane transporter activity|ion channel complex|regulation of ion transport|ion transmembrane transport|anion transport|ion channel activity|anion transmembrane transport|chloride channel complex|anion transmembrane transporter activity|anion channel activity|inorganic anion transport|chloride channel activity|chloride transmembrane transport|chloride transport|chloride transmembrane transporter activity - - - - 12:69643360-69699476 10 7 6 4 1 0 0.0608356093129484 0.0387065914863126 0.0329120419695778 0.0218047140644482 0.00499382709076739 0 0.0441514142562796 0.00893284705173853 2.30526768553066 0.00414783906453365 0.0199339322975833 UP ENSG00000109956 B3GAT1 beta-1,3-glucuronyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:921] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0031224|GO:0005622|GO:0012505|GO:0016740|GO:0031090|GO:0006486|GO:0006082|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0005975|GO:0016757|GO:0016021|GO:0044249|GO:0019538|GO:0005794|GO:0006790|GO:0034645|GO:0046872|GO:0043412|GO:0008194|GO:0030204|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0000139|GO:0009059|GO:0009101|GO:0043413|GO:0015020|GO:0050650|GO:0006024|GO:0006029|GO:0030203|GO:0006464|GO:0015018|GO:0030166 cell|membrane|cellular process|metabolic process|binding|catalytic activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intrinsic component of membrane|intracellular|endomembrane system|transferase activity|organelle membrane|protein glycosylation|organic acid metabolic process|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|carbohydrate metabolic process|transferase activity, transferring glycosyl groups|integral component of membrane|cellular biosynthetic process|protein metabolic process|Golgi apparatus|sulfur compound metabolic process|cellular macromolecule biosynthetic process|metal ion binding|macromolecule modification|UDP-glycosyltransferase activity|chondroitin sulfate metabolic process|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|macromolecule biosynthetic process|glycoprotein biosynthetic process|macromolecule glycosylation|glucuronosyltransferase activity|chondroitin sulfate proteoglycan biosynthetic process|glycosaminoglycan biosynthetic process|proteoglycan metabolic process|glycosaminoglycan metabolic process|cellular protein modification process|galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|proteoglycan biosynthetic process K00735 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1[2.4.1.135] hsa00514 Other types of O-glycan biosynthesis - Homo sapiens (human) 11:134378504-134411918 4 12 10 20 27 24 0.016678510480586 0.0454755732697968 0.0375961164800245 0.0747201682341811 0.0923726531826407 0.0937909360596817 0.0332500667434691 0.0869612524921678 -1.3870154829082 0.00415867077497575 0.0199802774732688 DOWN ENSG00000271092 TMEM56-RWDD3 TMEM56-RWDD3 readthrough [Source:HGNC Symbol;Acc:HGNC:49388] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 1:95117923-95247225 9 16 11 17 41 44 0.317682234035895 0.513271872886782 0.350062473945599 0.537645925753577 1.18739827678526 1.45555158701178 0.393672193622759 1.06019859651687 -1.42926781703946 0.00416073459540253 0.0199860300591345 DOWN ENSG00000274213 RP11-670E13.6 - - - - - - - 17:56914186-56914533 15 32 21 12 12 5 3.04895567441645 5.91147605324777 3.84857964871872 2.18554664161499 2.00134518467691 0.95258403344538 4.26967045879431 1.71315861991243 1.31746598869896 0.00416825520432005 0.0200030687782946 UP ENSG00000256566 RP4-734P14.4 - GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 20:2467212-2508907 19 13 8 3 6 5 1.63301436997519 1.01551075538976 0.619956763030022 0.230996960770937 0.423092346852144 0.402793734676783 1.08949396279832 0.352294347433288 1.62880497001151 0.00418631682968121 0.0200800614770731 UP ENSG00000272153 RP1-286D6.5 - - - - - - - 1:3785008-3785538 14 27 23 7 11 11 1.86503981586292 3.26890316533474 2.76245164170912 0.835468755445989 1.20226910863128 1.37328383409661 2.63213154096893 1.13700723272463 1.21099015814272 0.00421456712008342 0.0202058273330609 UP ENSG00000124140 SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 [Source:HGNC Symbol;Acc:HGNC:13818] GO:0032502|GO:0040007|GO:0005215|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0042995|GO:0022857|GO:0009628|GO:0044297|GO:0044708|GO:0071944|GO:0031224|GO:0048589|GO:0005515|GO:0005886|GO:0043198|GO:0043025|GO:0006810|GO:0050877|GO:0005887|GO:0019899|GO:0007267|GO:0035264|GO:0042592|GO:0043005|GO:0019725|GO:0036477|GO:0022891|GO:0042493|GO:0031226|GO:0007154|GO:0055085|GO:0007611|GO:0071804|GO:0016021|GO:0009266|GO:0040040|GO:0007612|GO:0048878|GO:0006811|GO:0055082|GO:0015075|GO:0030425|GO:0019900|GO:0050890|GO:0071805|GO:0034220|GO:0098655|GO:0006820|GO:0098656|GO:0015293|GO:0008509|GO:0006812|GO:0050801|GO:0019901|GO:0006873|GO:0008324|GO:0022820|GO:0022890|GO:0030001|GO:0015698|GO:0015672|GO:0015377|GO:0007268|GO:0006813|GO:1902476|GO:0006821|GO:0015108|GO:0015077|GO:0046873|GO:0015379|GO:0015079 developmental process|growth|transporter activity|behavior|signaling|cell|membrane|cellular process|response to stimulus|binding|cell projection|transmembrane transporter activity|response to abiotic stimulus|cell body|single-organism behavior|cell periphery|intrinsic component of membrane|developmental growth|protein binding|plasma membrane|dendritic shaft|neuronal cell body|transport|neurological system process|integral component of plasma membrane|enzyme binding|cell-cell signaling|multicellular organism growth|homeostatic process|neuron projection|cellular homeostasis|somatodendritic compartment|substrate-specific transmembrane transporter activity|response to drug|intrinsic component of plasma membrane|cell communication|transmembrane transport|learning or memory|cellular potassium ion transport|integral component of membrane|response to temperature stimulus|thermosensory behavior|learning|chemical homeostasis|ion transport|cellular chemical homeostasis|ion transmembrane transporter activity|dendrite|kinase binding|cognition|potassium ion transmembrane transport|ion transmembrane transport|cation transmembrane transport|anion transport|anion transmembrane transport|symporter activity|anion transmembrane transporter activity|cation transport|ion homeostasis|protein kinase binding|cellular ion homeostasis|cation transmembrane transporter activity|potassium ion symporter activity|inorganic cation transmembrane transporter activity|metal ion transport|inorganic anion transport|monovalent inorganic cation transport|cation:chloride symporter activity|synaptic transmission|potassium ion transport|chloride transmembrane transport|chloride transport|chloride transmembrane transporter activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium:chloride symporter activity|potassium ion transmembrane transporter activity K14427 solute carrier family 12 (potassium/chloride transporter), member 4/5/6[-] hsa04727 GABAergic synapse - Homo sapiens (human) 20:46021690-46060152 12 17 27 49 27 71 0.0436638555797993 0.0562169929531429 0.0885743547006016 0.159743099656233 0.0806033480062917 0.242109565136629 0.0628184010778479 0.160818670933051 -1.35617578457726 0.00422375789058659 0.0202433886764444 DOWN ENSG00000232553 CLK2P1 CDC like kinase 2, pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:2070] - - - - - - 7:23585062-23586355 12 6 7 1 5 1 0.656003876605006 0.298086408403723 0.344986854559602 0.0489557909588965 0.22426576137859 0.0512254601064282 0.433025713189444 0.108149004147972 2.00143231432385 0.00424222634652922 0.0203221157492432 UP ENSG00000162614 NEXN nexilin (F actin binding protein) [Source:HGNC Symbol;Acc:HGNC:29557] GO:0040011|GO:0032502|GO:0005198|GO:0005623|GO:0009987|GO:0030054|GO:0005488|GO:0030055|GO:0044877|GO:0050794|GO:0040012|GO:0043229|GO:0048870|GO:0016043|GO:0008307|GO:0005622|GO:0005515|GO:0048856|GO:0030017|GO:0007507|GO:0030018|GO:0009888|GO:0048468|GO:0007275|GO:0048513|GO:0005924|GO:0005912|GO:0051128|GO:0061061|GO:0005737|GO:0006928|GO:0032403|GO:0031674|GO:0051270|GO:0016477|GO:0008092|GO:0048869|GO:2000145|GO:0006996|GO:0007010|GO:0072358|GO:0042692|GO:0035051|GO:0048738|GO:0003779|GO:0055006|GO:0030334|GO:0060537|GO:0043292|GO:0055001|GO:0051015|GO:0033043|GO:0030154|GO:0072359|GO:0005856|GO:0005925|GO:0055002|GO:0030016|GO:0048739|GO:0055013|GO:0051493|GO:0051146|GO:0014706|GO:0055007|GO:0048747 locomotion|developmental process|structural molecule activity|cell|cellular process|cell junction|binding|cell-substrate junction|macromolecular complex binding|regulation of cellular process|regulation of locomotion|intracellular organelle|cell motility|cellular component organization|structural constituent of muscle|intracellular|protein binding|anatomical structure development|sarcomere|heart development|Z disc|tissue development|cell development|multicellular organism development|animal organ development|cell-substrate adherens junction|adherens junction|regulation of cellular component organization|muscle structure development|cytoplasm|movement of cell or subcellular component|protein complex binding|I band|regulation of cellular component movement|cell migration|cytoskeletal protein binding|cellular developmental process|regulation of cell motility|organelle organization|cytoskeleton organization|cardiovascular system development|muscle cell differentiation|cardiocyte differentiation|cardiac muscle tissue development|actin binding|cardiac cell development|regulation of cell migration|muscle tissue development|contractile fiber|muscle cell development|actin filament binding|regulation of organelle organization|cell differentiation|circulatory system development|cytoskeleton|focal adhesion|striated muscle cell development|myofibril|cardiac muscle fiber development|cardiac muscle cell development|regulation of cytoskeleton organization|striated muscle cell differentiation|striated muscle tissue development|cardiac muscle cell differentiation|muscle fiber development - - - - 1:77888513-77943895 150 168 64 62 88 38 1.15898397256876 1.17971237021122 0.445839632013347 0.429217326619297 0.5578760694881 0.275165526090103 0.928178658264442 0.420752974065833 1.14142905662009 0.00425084676479805 0.0203601442830548 UP ENSG00000186063 AIDA axin interactor, dorsalization associated [Source:HGNC Symbol;Acc:HGNC:25761] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0044237|GO:0023051|GO:0023057|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0007275|GO:0033554|GO:0051098|GO:0005737|GO:0007389|GO:0009966|GO:0019904|GO:0010646|GO:0007154|GO:0044092|GO:0007165|GO:0009968|GO:0050790|GO:0043086|GO:0019538|GO:0023014|GO:0031324|GO:0031323|GO:0000165|GO:0032268|GO:0043412|GO:0036211|GO:0032269|GO:0003002|GO:0031098|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:1902532|GO:0051246|GO:1902531|GO:0043393|GO:0043496|GO:0043408|GO:0016310|GO:0009953|GO:0032872|GO:0043409|GO:0033673|GO:0006464|GO:0051403|GO:0043549|GO:0045859|GO:0006469|GO:0046328|GO:0006468|GO:0043407|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0042326|GO:0001933|GO:0032873|GO:0071901|GO:0071900|GO:0043506|GO:0043508|GO:0046329 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|cellular metabolic process|regulation of signaling|negative regulation of signaling|intracellular|protein binding|anatomical structure development|regulation of metabolic process|multicellular organism development|cellular response to stress|regulation of binding|cytoplasm|pattern specification process|regulation of signal transduction|protein domain specific binding|regulation of cell communication|cell communication|negative regulation of molecular function|signal transduction|negative regulation of signal transduction|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|signal transduction by protein phosphorylation|negative regulation of cellular metabolic process|regulation of cellular metabolic process|MAPK cascade|regulation of cellular protein metabolic process|macromolecule modification|protein modification process|negative regulation of cellular protein metabolic process|regionalization|stress-activated protein kinase signaling cascade|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|negative regulation of intracellular signal transduction|regulation of protein metabolic process|regulation of intracellular signal transduction|regulation of protein binding|regulation of protein homodimerization activity|regulation of MAPK cascade|phosphorylation|dorsal/ventral pattern formation|regulation of stress-activated MAPK cascade|negative regulation of MAPK cascade|negative regulation of kinase activity|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|regulation of protein kinase activity|negative regulation of protein kinase activity|regulation of JNK cascade|protein phosphorylation|negative regulation of MAP kinase activity|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|negative regulation of phosphorylation|negative regulation of protein phosphorylation|negative regulation of stress-activated MAPK cascade|negative regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|negative regulation of JUN kinase activity|negative regulation of JNK cascade - - - - 1:222668013-222713210 317 91 88 325 341 1059 3.68203062385488 0.960619854491493 0.921565694417621 3.38228306338174 3.24975644794269 11.5279834070285 1.85473872425466 6.05334097278431 -1.70651564779034 0.00425751999920761 0.0203822966735638 DOWN ENSG00000272008 RP11-393I2.4 - - - - - - - 6:87151159-87155285 5 3 6 0 1 1 0.0857041301708927 0.0467391157972082 0.0927231189678413 0 0.0140691125719294 0.0160614842204308 0.0750554549786474 0.0100435322641201 2.90169018199038 0.00428822412610398 0.0205128413813024 UP ENSG00000280311 RP13-554M15.5 - - - - - - - 12:132621999-132622973 7 3 7 1 1 1 0.507864688319594 0.197838288097516 0.457859476718077 0.0649731215392944 0.0595520282916435 0.0679853798745827 0.387854151045062 0.0641701765685069 2.59553938429202 0.00428730953821156 0.0205128413813024 UP ENSG00000204936 CD177 CD177 molecule [Source:HGNC Symbol;Acc:HGNC:30072] GO:0040011|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:1903561|GO:0006950|GO:0050900|GO:0048870|GO:0043227|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0031225|GO:0050817|GO:0031982|GO:0009611|GO:0006928|GO:0016477|GO:0070062|GO:0050878|GO:0007596|GO:0042060|GO:0007599 locomotion|immune system process|cell|membrane|cellular process|extracellular region|response to stimulus|binding|extracellular vesicle|response to stress|leukocyte migration|cell motility|membrane-bounded organelle|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|anchored component of membrane|coagulation|vesicle|response to wounding|movement of cell or subcellular component|cell migration|extracellular exosome|regulation of body fluid levels|blood coagulation|wound healing|hemostasis - - - - 19:43353659-43363172 7 15 20 30 39 32 0.153635765160287 0.299205695266495 0.395768240749075 0.589935296305615 0.702289113514701 0.658214681690533 0.282869900391952 0.65014636383695 -1.20062586995027 0.00429036549209445 0.0205143492067879 DOWN ENSG00000244255 XXbac-BPG116M5.17 - GO:0008152|GO:0003824|GO:0071704|GO:0016787|GO:0008233|GO:0019538|GO:0017171|GO:0006508|GO:0008236|GO:0004252|GO:0004175 metabolic process|catalytic activity|organic substance metabolic process|hydrolase activity|peptidase activity|protein metabolic process|serine hydrolase activity|proteolysis|serine-type peptidase activity|serine-type endopeptidase activity|endopeptidase activity - - - - 6:31927698-31952048 0 0 0 0 0 29 0 0 0 0 0 0.447092596791867 0 0.149030865597289 -Inf 0.00432945167297798 0.0206771673591514 DOWN ENSG00000235098 ANKRD65 ankyrin repeat domain 65 [Source:HGNC Symbol;Acc:HGNC:42950] GO:0005488|GO:0005515 binding|protein binding - - - - 1:1418420-1421769 6 11 11 3 2 4 0.0708753135753157 0.118101327242424 0.117155176651132 0.0317485802796395 0.019383489281859 0.0442790550285358 0.102043939156291 0.0318037081966781 1.68192360341283 0.00435136829729498 0.020760759491666 UP ENSG00000272599 RP11-152N13.16 - - - - - - - 10:73124573-73125532 23 25 27 81 58 37 1.11056064111341 1.09707370418744 1.17540889401665 3.50422441339488 2.29775711001304 1.67430351261241 1.1276810797725 2.49209501200678 -1.14399995678327 0.00435079535218898 0.020760759491666 DOWN ENSG00000204652 RPS26P8 ribosomal protein S26 pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:31329] - - - - - - 17:45608571-45608918 8 5 1 0 1 0 1.62605891834862 0.923755560497751 0.183174361551277 0 0.16684835512745 0 0.910996280132549 0.0556161183758167 4.03387020001143 0.00436171854334538 0.0208044009255525 UP ENSG00000121797 CCRL2 chemokine (C-C motif) receptor-like 2 [Source:HGNC Symbol;Acc:HGNC:1612] GO:0040011|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0006950|GO:0038023|GO:0071944|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0006935|GO:0005102|GO:0006952|GO:0005887|GO:0004888|GO:0031226|GO:0007154|GO:0007165|GO:0016021|GO:0010033|GO:0007186|GO:0005126|GO:0007166|GO:0004896|GO:0034097|GO:0006954|GO:0001664|GO:0071310|GO:0008528|GO:0004930|GO:0019221|GO:0042379|GO:0071345|GO:0004950|GO:0048020|GO:0070098 locomotion|signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|response to stress|signaling receptor activity|cell periphery|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|chemotaxis|receptor binding|defense response|integral component of plasma membrane|transmembrane signaling receptor activity|intrinsic component of plasma membrane|cell communication|signal transduction|integral component of membrane|response to organic substance|G-protein coupled receptor signaling pathway|cytokine receptor binding|cell surface receptor signaling pathway|cytokine receptor activity|response to cytokine|inflammatory response|G-protein coupled receptor binding|cellular response to organic substance|G-protein coupled peptide receptor activity|G-protein coupled receptor activity|cytokine-mediated signaling pathway|chemokine receptor binding|cellular response to cytokine stimulus|chemokine receptor activity|CCR chemokine receptor binding|chemokine-mediated signaling pathway - - - - 3:46407163-46412997 21 19 26 13 8 10 0.221584757359011 0.182203037613394 0.247339290507281 0.12289961586856 0.069261852122318 0.0988854371312027 0.217042361826562 0.0970156350406936 1.16168747613979 0.00437061843583624 0.0208421637334885 UP ENSG00000226380 AC058791.1 - - - - - - - 7:130876809-130913310 19 16 45 59 70 55 0.178032961516702 0.136256038318335 0.380171177284607 0.495346950123881 0.538174896070562 0.482996303653054 0.231486725706548 0.505506049949166 -1.12679889209646 0.00437103192655495 0.0208421637334885 DOWN ENSG00000243265 RPL23AP55 ribosomal protein L23a pseudogene 55 [Source:HGNC Symbol;Acc:HGNC:35997] - - - - - - 8:23206918-23207369 3 4 2 0 0 0 0.469543848050761 0.56891417769088 0.282203769896962 0 0 0 0.440220598546201 0 Inf 0.00439963562851022 0.0209718540720971 UP ENSG00000236792 RP11-142L4.2 - - - - - - - 1:192247505-192247947 29 26 15 12 12 7 4.63063818717863 3.7730696479815 2.15945238323665 1.71686282456437 1.57216280873039 1.04756373452467 3.52105340613226 1.44552978927314 1.28440876969496 0.00441509636827205 0.0210421914077895 UP ENSG00000222898 RN7SKP97 RNA, 7SK small nuclear pseudogene 97 [Source:HGNC Symbol;Acc:HGNC:45821] - - - - - - 8:61631680-61632012 2 1 1 6 6 9 0.424826203892883 0.193146326537355 0.191425458918452 1.14199734426729 1.04566066504299 1.79171839384344 0.269799329782897 1.32645880105124 -2.297621197533 0.00445810178277175 0.0212234365528413 DOWN ENSG00000236512 RP3-336K20__B.2 - - - - - - - 6:7620422-7620878 5 8 4 2 1 0 0.773962680996223 1.1253794674673 0.558232402597055 0.277377910752012 0.127053014407773 0 0.819191517020193 0.134810308386595 2.60326995820561 0.00446545193494787 0.0212448768232564 UP ENSG00000243811 APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D [Source:HGNC Symbol;Acc:HGNC:17354] GO:0032991|GO:0002376|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051707|GO:0009607|GO:0009605|GO:0016787|GO:0005622|GO:0019222|GO:0016032|GO:0045087|GO:0006725|GO:1901360|GO:0034641|GO:0006952|GO:0046483|GO:0098542|GO:0043169|GO:0005737|GO:0030529|GO:0016810|GO:0009615|GO:0010529|GO:0006139|GO:0048525|GO:0051607|GO:0050792|GO:0031324|GO:0031323|GO:0035770|GO:0051053|GO:0046872|GO:0043412|GO:0051252|GO:0039692|GO:0006259|GO:0019079|GO:0019058|GO:0016070|GO:0016814|GO:0036464|GO:0045091|GO:0045069|GO:0006304|GO:0045071|GO:0046914|GO:0045869|GO:0000932|GO:0045006|GO:0008270|GO:0070383 macromolecular complex|immune system process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|response to other organism|response to biotic stimulus|response to external stimulus|hydrolase activity|intracellular|regulation of metabolic process|viral process|innate immune response|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|defense response|heterocycle metabolic process|defense response to other organism|cation binding|cytoplasm|intracellular ribonucleoprotein complex|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|response to virus|negative regulation of transposition|nucleobase-containing compound metabolic process|negative regulation of viral process|defense response to virus|regulation of viral process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|ribonucleoprotein granule|negative regulation of DNA metabolic process|metal ion binding|macromolecule modification|regulation of RNA metabolic process|single stranded viral RNA replication via double stranded DNA intermediate|DNA metabolic process|viral genome replication|viral life cycle|RNA metabolic process|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|cytoplasmic ribonucleoprotein granule|regulation of single stranded viral RNA replication via double stranded DNA intermediate|regulation of viral genome replication|DNA modification|negative regulation of viral genome replication|transition metal ion binding|negative regulation of single stranded viral RNA replication via double stranded DNA intermediate|cytoplasmic mRNA processing body|DNA deamination|zinc ion binding|DNA cytosine deamination - - - - 22:39014363-39033276 25 32 32 9 11 22 0.46995441539396 0.54668978648159 0.542341460414854 0.151580019759631 0.169653174776298 0.387589143917354 0.519661887430135 0.236274112817761 1.13711168380308 0.00447572174437504 0.021290343683329 UP ENSG00000240915 RP11-659E9.2 - - - - - - - 8:63013068-63014681 4 2 3 0 0 0 0.514425912350291 0.233772007560253 0.347819603296857 0 0 0 0.365339174402467 0 Inf 0.00448375474042917 0.0213217607551406 UP ENSG00000255508 RP11-864I4.1 - GO:0005488|GO:0036094|GO:0097159|GO:0003676|GO:0000166 binding|small molecule binding|organic cyclic compound binding|nucleic acid binding|nucleotide binding - - - - 11:62559603-62591531 25 633 1785 23 70 282 0.299278806080127 6.88676470480773 19.2656714355039 0.246696150084816 0.687541426711233 3.16380220837363 8.81723831546392 1.36601326172323 2.6903553640417 0.00448943918406648 0.021341993216739 UP ENSG00000260630 SNAI3-AS1 SNAI3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:28327] - - - - - - 16:88663298-88687186 17 15 40 7 11 12 0.151220284279836 0.121270115171518 0.320806756981238 0.0557889724775931 0.0802823059209269 0.10003765861205 0.197765718810864 0.0787029790035233 1.32930221787169 0.0044909741256454 0.0213426581898581 UP ENSG00000236782 RP11-96L14.7 - - - - - - - 1:26169516-26171821 48 44 26 13 30 13 0.983872368417768 0.819658444357884 0.480487569852452 0.238747906341011 0.504532381916674 0.24974086450627 0.761339460876035 0.331007050921318 1.2016779074415 0.00449983351798715 0.0213777895999345 UP ENSG00000235092 ID2-AS1 ID2 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:51103] - - - - - - 2:8666636-8681863 0 1 1 7 5 4 0 0.0169435528811748 0.0167925916279885 0.116868785337677 0.0764488659704678 0.0698479930218315 0.0112453815030544 0.0877218814433254 -2.96360414918764 0.00451448008506655 0.0214371382948269 DOWN ENSG00000266978 CTD-2369P2.5 - - - - - - - 19:10252268-10285108 32 36 24 16 19 12 2.46580232705782 2.52107066976743 1.66732734157667 1.10460732407114 1.20123785763751 0.866557147367123 2.21806677946731 1.05746744302526 1.06868955466994 0.00455700793479168 0.0216253242545336 UP ENSG00000140481 CCDC33 coiled-coil domain containing 33 [Source:HGNC Symbol;Acc:HGNC:26552] GO:0005488|GO:0005515 binding|protein binding - - - - 15:74236289-74336472 0 0 0 1 1 14 0 0 0 0.00854217819590238 0.00782945355776058 0.125153919739598 0 0.047175183831087 -Inf 0.00459070625581317 0.0217713970708573 DOWN ENSG00000248727 CTC-236F12.4 - - - - - - - 5:56457795-56481946 0 1 1 7 4 5 0 0.0567676317183931 0.0562618515620869 0.391556848315817 0.204886732250259 0.292585387148272 0.0376764944268267 0.296342989238116 -2.97553128508106 0.00460147985831152 0.0218190247284041 DOWN ENSG00000132970 WASF3 WAS protein family member 3 [Source:HGNC Symbol;Acc:HGNC:12734] GO:0032502|GO:0005623|GO:0009987|GO:0005576|GO:0005488|GO:1903561|GO:0042995|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0043227|GO:0031252|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0008360|GO:0048468|GO:0031643|GO:0031641|GO:0007275|GO:0050877|GO:0031982|GO:0051128|GO:0022607|GO:0005737|GO:0030027|GO:0070062|GO:0008092|GO:0030030|GO:0048869|GO:0030029|GO:0006996|GO:0000902|GO:0007010|GO:0007417|GO:0021782|GO:0003779|GO:0030031|GO:0031644|GO:0022604|GO:0006461|GO:0030036|GO:0097581|GO:0007399|GO:0030154|GO:0005856|GO:0051960|GO:0008366|GO:0030032|GO:0010001|GO:0034622|GO:0014003|GO:0043623|GO:0048709|GO:0042552|GO:0022008|GO:0007015|GO:0051258|GO:0042063|GO:0008154|GO:0030041 developmental process|cell|cellular process|extracellular region|binding|extracellular vesicle|cell projection|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell leading edge|regulation of developmental process|intracellular|protein binding|anatomical structure development|regulation of cell shape|cell development|positive regulation of myelination|regulation of myelination|multicellular organism development|neurological system process|vesicle|regulation of cellular component organization|cellular component assembly|cytoplasm|lamellipodium|extracellular exosome|cytoskeletal protein binding|cell projection organization|cellular developmental process|actin filament-based process|organelle organization|cell morphogenesis|cytoskeleton organization|central nervous system development|glial cell development|actin binding|cell projection assembly|regulation of neurological system process|regulation of cell morphogenesis|protein complex assembly|actin cytoskeleton organization|lamellipodium organization|nervous system development|cell differentiation|cytoskeleton|regulation of nervous system development|axon ensheathment|lamellipodium assembly|glial cell differentiation|cellular macromolecular complex assembly|oligodendrocyte development|cellular protein complex assembly|oligodendrocyte differentiation|myelination|neurogenesis|actin filament organization|protein polymerization|gliogenesis|actin polymerization or depolymerization|actin filament polymerization K06083 WAS protein family, member 3[-] hsa05231|hsa04666|hsa04520 Choline metabolism in cancer - Homo sapiens (human)|Fc gamma R-mediated phagocytosis - Homo sapiens (human)|Adherens junction - Homo sapiens (human) 13:26557703-26688948 0 2 7 6 16 17 0 0.0150133820829214 0.0521266919430319 0.0444050812285157 0.108431199428667 0.131597233176321 0.0223800246753178 0.0948111712778346 -2.08284543001567 0.00460633292694254 0.0218364327932838 DOWN ENSG00000164708 PGAM2 phosphoglycerate mutase 2 [Source:HGNC Symbol;Acc:HGNC:8889] GO:0000003|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0009056|GO:0019953|GO:0044237|GO:0043227|GO:0048037|GO:0016853|GO:0032504|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0048609|GO:0019222|GO:0044262|GO:0006081|GO:0006725|GO:1901360|GO:0006082|GO:0016866|GO:0034641|GO:0016788|GO:0044281|GO:0031982|GO:0019637|GO:0046483|GO:0043231|GO:0005737|GO:0003012|GO:0005975|GO:0051186|GO:0006139|GO:0055086|GO:0007154|GO:0007276|GO:0007165|GO:0070062|GO:0006091|GO:0010035|GO:0031323|GO:0055114|GO:0006109|GO:0016868|GO:0005829|GO:0006936|GO:0048232|GO:0007166|GO:0019693|GO:0010038|GO:0044275|GO:0009116|GO:0043456|GO:0005996|GO:0016052|GO:0051156|GO:0046689|GO:0006796|GO:0043603|GO:0051174|GO:0005634|GO:0016051|GO:0042578|GO:0019682|GO:0006757|GO:0006941|GO:0007283|GO:0019318|GO:0016311|GO:0006098|GO:0009259|GO:0009117|GO:0016310|GO:0010906|GO:0009132|GO:0061621|GO:0006163|GO:0016791|GO:0019752|GO:0004619|GO:0006096|GO:0007219|GO:0004082|GO:0042278|GO:0019319|GO:0046939|GO:0006006|GO:1902031|GO:0046538|GO:0061615|GO:0032787|GO:0006165|GO:0006007|GO:0006739|GO:0046034|GO:0019674|GO:0046031|GO:0006094|GO:0006090|GO:0004083|GO:0006734 reproduction|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|catabolic process|sexual reproduction|cellular metabolic process|membrane-bounded organelle|cofactor binding|isomerase activity|multicellular organism reproduction|hydrolase activity|biosynthetic process|intracellular|protein binding|multicellular organismal reproductive process|regulation of metabolic process|cellular carbohydrate metabolic process|cellular aldehyde metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|intramolecular transferase activity|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|small molecule metabolic process|vesicle|organophosphate metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|muscle system process|carbohydrate metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|cell communication|gamete generation|signal transduction|extracellular exosome|generation of precursor metabolites and energy|response to inorganic substance|regulation of cellular metabolic process|oxidation-reduction process|regulation of carbohydrate metabolic process|intramolecular transferase activity, phosphotransferases|cytosol|muscle contraction|male gamete generation|cell surface receptor signaling pathway|ribose phosphate metabolic process|response to metal ion|cellular carbohydrate catabolic process|nucleoside metabolic process|regulation of pentose-phosphate shunt|monosaccharide metabolic process|carbohydrate catabolic process|glucose 6-phosphate metabolic process|response to mercury ion|phosphate-containing compound metabolic process|cellular amide metabolic process|regulation of phosphorus metabolic process|nucleus|carbohydrate biosynthetic process|phosphoric ester hydrolase activity|glyceraldehyde-3-phosphate metabolic process|ATP generation from ADP|striated muscle contraction|spermatogenesis|hexose metabolic process|dephosphorylation|pentose-phosphate shunt|ribonucleotide metabolic process|nucleotide metabolic process|phosphorylation|regulation of glucose metabolic process|nucleoside diphosphate metabolic process|canonical glycolysis|purine nucleotide metabolic process|phosphatase activity|carboxylic acid metabolic process|phosphoglycerate mutase activity|glycolytic process|Notch signaling pathway|bisphosphoglycerate mutase activity|purine nucleoside metabolic process|hexose biosynthetic process|nucleotide phosphorylation|glucose metabolic process|regulation of NADP metabolic process|2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity|glycolytic process through fructose-6-phosphate|monocarboxylic acid metabolic process|nucleoside diphosphate phosphorylation|glucose catabolic process|NADP metabolic process|ATP metabolic process|NAD metabolic process|ADP metabolic process|gluconeogenesis|pyruvate metabolic process|bisphosphoglycerate 2-phosphatase activity|NADH metabolic process K01834 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase[5.4.2.11] hsa01100|hsa01200|hsa04922|hsa01230|hsa05230|hsa00010|hsa00260 Metabolic pathways - Homo sapiens (human)|Carbon metabolism - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Biosynthesis of amino acids - Homo sapiens (human)|Central carbon metabolism in cancer - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human)|Glycine, serine and threonine metabolism - Homo sapiens (human) 7:44062727-44065587 4 3 2 0 0 0 0.330144984588868 0.225078565805226 0.148840261369226 0 0 0 0.23468793725444 0 Inf 0.00460661397910168 0.0218364327932838 UP ENSG00000233247 GS1-257G1.1 - - - - - - - X:14244382-14244928 37 37 47 114 88 58 4.78471886746884 4.34855685847064 5.47983239728506 13.2087033351572 9.33703001126792 7.0293726675694 4.87103604107485 9.85836867133151 -1.01712027637865 0.00460898569705756 0.0218442068582245 DOWN ENSG00000228412 RP4-625H18.2 - - - - - - - 6:19802164-19804752 3 1 2 11 13 5 0.0527944824176478 0.0159994345116765 0.0317303741277182 0.173422218798298 0.187679908085319 0.0824624984176598 0.0335080970190142 0.147854875100426 -2.14160015215874 0.00461530667359928 0.0218672219383642 DOWN ENSG00000106560 GIMAP2 GTPase, IMAP family member 2 [Source:HGNC Symbol;Acc:HGNC:21789] GO:0005623|GO:0016020|GO:0005488|GO:0036094|GO:0097159|GO:0043229|GO:0043167|GO:0031224|GO:0005622|GO:0043168|GO:0001882|GO:0005737|GO:0000166|GO:0016021|GO:0035639|GO:0005811|GO:0001883|GO:0032549|GO:0017076|GO:0032561|GO:0005525|GO:0019001 cell|membrane|binding|small molecule binding|organic cyclic compound binding|intracellular organelle|ion binding|intrinsic component of membrane|intracellular|anion binding|nucleoside binding|cytoplasm|nucleotide binding|integral component of membrane|purine ribonucleoside triphosphate binding|lipid particle|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|guanyl ribonucleotide binding|GTP binding|guanyl nucleotide binding - - - - 7:150685697-150693641 4 6 12 1 2 2 0.124202920014337 0.169325641999305 0.335968667234663 0.0278089523708569 0.0509518585688198 0.0581964401911485 0.209832409749435 0.0456524170436084 2.20047437708289 0.00464193006693471 0.0219794100266881 UP ENSG00000272750 RP11-378J18.8 - - - - - - - 1:222658867-222661512 4 9 17 18 32 34 0.106929044517256 0.218675791144934 0.409748114046584 0.431138030503016 0.701893266747624 0.851850872956925 0.245117649902925 0.661627390069188 -1.43254459005801 0.00467599546285672 0.0221336877355517 DOWN ENSG00000259630 CTD-2262B20.1 - - - - - - - 15:85415228-85415633 3 5 4 0 1 0 0.5227433973373 0.791790480426644 0.628355192085847 0 0.143012875823528 0 0.64762968994993 0.0476709586078427 3.76398658435954 0.00467919009808991 0.0221452982226341 UP ENSG00000272911 RP11-74E22.6 - - - - - - - 17:2688473-2688960 12 6 2 2 1 0 2.80154790866957 1.27301588275385 0.420977240902399 0.418355462751384 0.191627813809744 0 1.49851367744194 0.203327758853709 2.88165315752084 0.00468922213681193 0.0221892594186691 UP ENSG00000230578 RP13-228J13.5 - - - - - - - X:155348752-155349799 6 7 5 16 19 18 0.608897242021507 0.645683700446709 0.457470424399854 1.45484867072785 1.58211815396159 1.71202934045872 0.570683788956023 1.58299872171605 -1.4718966034805 0.00469025667666714 0.0221906375317307 DOWN ENSG00000099957 P2RX6 purinergic receptor P2X, ligand gated ion channel, 6 [Source:HGNC Symbol;Acc:HGNC:8538] GO:0004871|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0042995|GO:0097159|GO:0004872|GO:0022857|GO:0050794|GO:0060076|GO:0043229|GO:0043167|GO:0038023|GO:0044297|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0042802|GO:0019866|GO:0043025|GO:0006810|GO:0043168|GO:0001882|GO:0022607|GO:0005887|GO:0043231|GO:0010243|GO:0004888|GO:0005737|GO:0003012|GO:0005635|GO:0043005|GO:0043197|GO:0036477|GO:0014069|GO:0022891|GO:0031226|GO:0007154|GO:0055085|GO:0007165|GO:0031965|GO:0000166|GO:0016021|GO:0031301|GO:0010033|GO:0005639|GO:0006936|GO:0007166|GO:0014074|GO:0035639|GO:0044309|GO:0046683|GO:0001883|GO:0015267|GO:0006811|GO:0032549|GO:0015075|GO:0005637|GO:0030425|GO:0033198|GO:0006461|GO:0014070|GO:0017076|GO:0005634|GO:0034220|GO:0015276|GO:0098655|GO:0005216|GO:0051259|GO:0005524|GO:0006812|GO:0030554|GO:0001614|GO:0008324|GO:0035590|GO:0051291|GO:0005230|GO:0005261|GO:0051260|GO:0004931|GO:0005231 signal transducer activity|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|small molecule binding|cellular response to stimulus|cell projection|organic cyclic compound binding|receptor activity|transmembrane transporter activity|regulation of cellular process|excitatory synapse|intracellular organelle|ion binding|signaling receptor activity|cell body|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|organelle membrane|identical protein binding|organelle inner membrane|neuronal cell body|transport|anion binding|nucleoside binding|cellular component assembly|integral component of plasma membrane|intracellular membrane-bounded organelle|response to organonitrogen compound|transmembrane signaling receptor activity|cytoplasm|muscle system process|nuclear envelope|neuron projection|dendritic spine|somatodendritic compartment|postsynaptic density|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|cell communication|transmembrane transport|signal transduction|nuclear membrane|nucleotide binding|integral component of membrane|integral component of organelle membrane|response to organic substance|integral component of nuclear inner membrane|muscle contraction|cell surface receptor signaling pathway|response to purine-containing compound|purine ribonucleoside triphosphate binding|neuron spine|response to organophosphorus|purine nucleoside binding|channel activity|ion transport|ribonucleoside binding|ion transmembrane transporter activity|nuclear inner membrane|dendrite|response to ATP|protein complex assembly|response to organic cyclic compound|purine nucleotide binding|nucleus|ion transmembrane transport|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|protein oligomerization|ATP binding|cation transport|adenyl nucleotide binding|purinergic nucleotide receptor activity|cation transmembrane transporter activity|purinergic nucleotide receptor signaling pathway|protein heterooligomerization|extracellular ligand-gated ion channel activity|cation channel activity|protein homooligomerization|extracellular ATP-gated cation channel activity|excitatory extracellular ligand-gated ion channel activity K05221 P2X purinoceptor 6[-] hsa04080|hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Calcium signaling pathway - Homo sapiens (human) 22:21009808-21028830 10 15 16 22 34 49 0.0699155510014481 0.0953187660219346 0.100864765439104 0.137818981826462 0.195045756413362 0.32108575902052 0.0886996941541622 0.217983499086781 -1.29721789493355 0.00469636124282505 0.0222159988184597 DOWN ENSG00000240160 RN7SL263P RNA, 7SL, cytoplasmic 263, pseudogene [Source:HGNC Symbol;Acc:HGNC:46279] - - - - - - 22:23261782-23262071 3 5 4 0 1 0 0.731840756272221 1.1085066725973 0.879697268920186 0 0.20021802615294 0 0.906681565929902 0.06673934205098 3.76398658435954 0.00469736713252132 0.0222172367513136 UP ENSG00000273297 RP11-38M8.1 - - - - - - - 7:134416290-134432453 24 22 49 79 62 65 0.880078678955344 0.733188515157869 1.62002303022724 2.5956076000051 1.86539701078728 2.23387122009066 1.07776340811348 2.23162527696101 -1.05005428683171 0.00470413019982702 0.0222386544712012 DOWN ENSG00000270240 AC015849.2 - - - - - - - 17:35868967-35885863 3 5 4 0 0 1 0.221307423690244 0.335210568355805 0.266018986430505 0 0 0.069119651071656 0.274178992825518 0.023039883690552 3.57291269933819 0.00470839678574668 0.0222553004499179 UP ENSG00000244122 UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 [Source:HGNC Symbol;Acc:HGNC:12539] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0042175|GO:0071704|GO:0043167|GO:0008144|GO:0044237|GO:0042445|GO:0043227|GO:0008289|GO:0009058|GO:0031224|GO:0030234|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0042802|GO:0019840|GO:0044262|GO:0044255|GO:0004857|GO:0006725|GO:1901360|GO:0006082|GO:0009410|GO:0043168|GO:0044281|GO:0046483|GO:0043231|GO:0019899|GO:0005737|GO:0005975|GO:0043177|GO:0046983|GO:0044092|GO:0009812|GO:0006629|GO:0005783|GO:0016757|GO:0042180|GO:0007588|GO:0006805|GO:0017144|GO:0050790|GO:0045833|GO:0043086|GO:0010817|GO:0016021|GO:0031324|GO:0031323|GO:0006109|GO:0042573|GO:0046982|GO:0006720|GO:0008194|GO:0006631|GO:0052696|GO:0005501|GO:0052697|GO:0051552|GO:0016758|GO:0071466|GO:0005996|GO:0010565|GO:0019900|GO:0009813|GO:0031406|GO:0009804|GO:0019216|GO:0045922|GO:0042803|GO:0019217|GO:2001030|GO:0015020|GO:1904224|GO:0019752|GO:0019901|GO:0001972|GO:0005080|GO:0016101|GO:0032787|GO:0052695|GO:0001523 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|drug binding|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|lipid binding|biosynthetic process|intrinsic component of membrane|enzyme regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|identical protein binding|isoprenoid binding|cellular carbohydrate metabolic process|cellular lipid metabolic process|enzyme inhibitor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|response to xenobiotic stimulus|anion binding|small molecule metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|carbohydrate metabolic process|organic acid binding|protein dimerization activity|negative regulation of molecular function|flavonoid metabolic process|lipid metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular ketone metabolic process|excretion|xenobiotic metabolic process|drug metabolic process|regulation of catalytic activity|negative regulation of lipid metabolic process|negative regulation of catalytic activity|regulation of hormone levels|integral component of membrane|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of carbohydrate metabolic process|retinoic acid metabolic process|protein heterodimerization activity|isoprenoid metabolic process|UDP-glycosyltransferase activity|fatty acid metabolic process|flavonoid glucuronidation|retinoid binding|xenobiotic glucuronidation|flavone metabolic process|transferase activity, transferring hexosyl groups|cellular response to xenobiotic stimulus|monosaccharide metabolic process|regulation of cellular ketone metabolic process|kinase binding|flavonoid biosynthetic process|carboxylic acid binding|coumarin metabolic process|regulation of lipid metabolic process|negative regulation of fatty acid metabolic process|protein homodimerization activity|regulation of fatty acid metabolic process|negative regulation of cellular glucuronidation|glucuronosyltransferase activity|negative regulation of glucuronosyltransferase activity|carboxylic acid metabolic process|protein kinase binding|retinoic acid binding|protein kinase C binding|diterpenoid metabolic process|monocarboxylic acid metabolic process|cellular glucuronidation|retinoid metabolic process K00699 glucuronosyltransferase[2.4.1.17] hsa01100|hsa05204|hsa00980|hsa00982|hsa00830|hsa00140|hsa00500|hsa00983|hsa00860|hsa00040|hsa00053 Metabolic pathways - Homo sapiens (human)|Chemical carcinogenesis - Homo sapiens (human)|Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human)|Drug metabolism - cytochrome P450 - Homo sapiens (human)|Retinol metabolism - Homo sapiens (human)|Steroid hormone biosynthesis - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Drug metabolism - other enzymes - Homo sapiens (human)|Porphyrin and chlorophyll metabolism - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human)|Ascorbate and aldarate metabolism - Homo sapiens (human) 2:233681938-233773299 2 3 9 15 16 13 0.030807300935612 0.0420061696200084 0.124993269554345 0.207029775696102 0.202222297889178 0.18768635091706 0.0659355800366551 0.198979474834113 -1.59349053639186 0.00472121954054536 0.0223017861018103 DOWN ENSG00000260643 RP11-303E16.8 - - - - - - - 16:81053665-81087651 28 9 32 11 10 6 2.56223288938877 0.748533173828584 2.64014348711655 0.901885277579766 0.750840608599989 0.514598950862497 1.98363651677797 0.722441612347417 1.45719479031014 0.00475199198658887 0.0224329488879861 UP ENSG00000215022 RP1-257A7.4 - - - - - - - 6:13264861-13295586 34 37 33 3 12 26 0.718146808640014 0.710259958669287 0.628439039030958 0.0567663477797795 0.207963011127967 0.514673314443678 0.685615268780086 0.259800891117141 1.39999285965744 0.00475992476876443 0.0224593007145256 UP ENSG00000206559 ZCWPW2 zinc finger, CW type with PWWP domain 2 [Source:HGNC Symbol;Acc:HGNC:23574] GO:0005488|GO:0043167|GO:0043169|GO:0046872|GO:0046914|GO:0008270 binding|ion binding|cation binding|metal ion binding|transition metal ion binding|zinc ion binding - - - - 3:28349146-28538122 0 2 0 3 4 12 0 0.0386574275881356 0 0.0571588991925681 0.0697945482981188 0.239176025641317 0.0128858091960452 0.122043157710668 -3.24353637066743 0.00476303834103992 0.0224673323800609 DOWN ENSG00000279320 RP11-329N15.3 - - - - - - - 3:146504570-146506560 7 5 12 2 1 3 0.248703199955602 0.161460037696242 0.384398103445787 0.0636673557075185 0.0291628466018847 0.0998780693787817 0.264853780365877 0.0642360905627283 2.04374010338355 0.00477253992193312 0.0225050397771902 UP ENSG00000108551 RASD1 RAS, dexamethasone-induced 1 [Source:HGNC Symbol;Acc:HGNC:15828] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0043227|GO:0071944|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0019222|GO:0006725|GO:0006810|GO:1901360|GO:0034641|GO:0043168|GO:0001882|GO:0046483|GO:0016817|GO:0043231|GO:0005737|GO:0045184|GO:0009890|GO:0006139|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0051649|GO:0000166|GO:0044249|GO:0031324|GO:0031323|GO:0007186|GO:0010468|GO:0034645|GO:0016528|GO:0035639|GO:0010629|GO:0051252|GO:0001883|GO:0015031|GO:0016818|GO:0046907|GO:0032549|GO:0048471|GO:0034613|GO:0035556|GO:0010467|GO:0017076|GO:0009059|GO:0016070|GO:0005634|GO:0016529|GO:0032561|GO:0051169|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006886|GO:0005525|GO:0007264|GO:0019932|GO:0019001|GO:0016462|GO:0006351|GO:0006355|GO:0006913|GO:1903507|GO:1903506|GO:0017111|GO:0007263|GO:0003924 signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|membrane-bounded organelle|cell periphery|hydrolase activity|biosynthetic process|intracellular|protein binding|plasma membrane|endomembrane system|regulation of metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|anion binding|nucleoside binding|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|protein localization|cell communication|signal transduction|endoplasmic reticulum|establishment of localization in cell|nucleotide binding|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|G-protein coupled receptor signaling pathway|regulation of gene expression|cellular macromolecule biosynthetic process|sarcoplasm|purine ribonucleoside triphosphate binding|negative regulation of gene expression|regulation of RNA metabolic process|purine nucleoside binding|protein transport|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|ribonucleoside binding|perinuclear region of cytoplasm|cellular protein localization|intracellular signal transduction|gene expression|purine nucleotide binding|macromolecule biosynthetic process|RNA metabolic process|nucleus|sarcoplasmic reticulum|guanyl ribonucleotide binding|nuclear transport|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|intracellular protein transport|GTP binding|small GTPase mediated signal transduction|second-messenger-mediated signaling|guanyl nucleotide binding|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|nucleoside-triphosphatase activity|nitric oxide mediated signal transduction|GTPase activity K07843 RAS, dexamethasone-induced Ras-related protein 1[-] hsa04713 Circadian entrainment - Homo sapiens (human) 17:17494437-17496395 13 12 15 6 5 5 0.291926809143046 0.244904007920265 0.303694414531376 0.120725433536828 0.0921269508647288 0.10523785512349 0.280175077198229 0.106030079841682 1.40185502412506 0.00478121970765764 0.0225424088996227 UP ENSG00000233928 RP11-305F18.1 - - - - - - - X:33726508-33942280 0 1 2 3 13 5 0 0.0877458754937781 0.17401924146443 0.259359479828761 1.02929499386491 0.452249991321954 0.0872550389860694 0.580301488338542 -2.73349227446922 0.00478438015721475 0.0225537478625437 DOWN ENSG00000187094 CCK cholecystokinin [Source:HGNC Symbol;Acc:HGNC:1569] GO:0040011|GO:0032502|GO:0045202|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0007631|GO:0008283|GO:0050794|GO:0051050|GO:0006950|GO:0044089|GO:0071704|GO:0044237|GO:0051641|GO:0048870|GO:0044297|GO:0009653|GO:0016043|GO:0044708|GO:0009605|GO:0009893|GO:0005615|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:0008284|GO:0042127|GO:0042391|GO:0048468|GO:0043025|GO:0006810|GO:0051130|GO:0043195|GO:0010941|GO:0009991|GO:0007275|GO:0050877|GO:0005102|GO:0032940|GO:0006952|GO:0043270|GO:0031325|GO:0051128|GO:0022607|GO:0010942|GO:0032098|GO:0001662|GO:0003254|GO:0006928|GO:0042592|GO:0043005|GO:0043204|GO:0036477|GO:0051901|GO:0043085|GO:0007154|GO:0033555|GO:0016477|GO:0007165|GO:2000021|GO:0044306|GO:0008219|GO:0051047|GO:0050790|GO:0030030|GO:0048869|GO:0032094|GO:0042755|GO:0019538|GO:0031334|GO:0043254|GO:0031323|GO:0006996|GO:0032268|GO:0000902|GO:0031175|GO:0007186|GO:0032099|GO:0051899|GO:0051900|GO:0030424|GO:0043412|GO:0051345|GO:0042596|GO:0007005|GO:0048878|GO:0005179|GO:0051604|GO:0032461|GO:0051957|GO:0043194|GO:0000904|GO:0036211|GO:0001764|GO:0006811|GO:0044304|GO:0043679|GO:0007600|GO:0051046|GO:0032459|GO:0030425|GO:0031644|GO:0051247|GO:0006508|GO:0006461|GO:0032095|GO:0051881|GO:0043269|GO:0032270|GO:0012501|GO:0006796|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0007399|GO:0046903|GO:0051246|GO:0030154|GO:0048858|GO:0043068|GO:0031667|GO:0043203|GO:0014047|GO:0014049|GO:0043067|GO:0015837|GO:0097190|GO:0048666|GO:0030182|GO:0006820|GO:0015711|GO:0014048|GO:0005184|GO:0031401|GO:0043065|GO:0019233|GO:0051259|GO:0016485|GO:0030162|GO:0008637|GO:0045862|GO:0051882|GO:0016310|GO:0052547|GO:0061564|GO:0046942|GO:0001836|GO:0042981|GO:0044070|GO:0050801|GO:0006865|GO:0022008|GO:0048667|GO:0006464|GO:0048812|GO:0010952|GO:0046717|GO:0007205|GO:0006915|GO:0010950|GO:0051930|GO:0007409|GO:0043281|GO:0006468|GO:0048699|GO:0006835|GO:0042325|GO:0001932|GO:0018193|GO:0031638|GO:0043280|GO:0001934|GO:0006919|GO:0042327|GO:0052548|GO:0050731|GO:0050730|GO:2001056|GO:2000116|GO:0097202|GO:0018108 locomotion|developmental process|synapse|behavior|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|feeding behavior|cell proliferation|regulation of cellular process|positive regulation of transport|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|cellular metabolic process|cellular localization|cell motility|cell body|anatomical structure morphogenesis|cellular component organization|single-organism behavior|response to external stimulus|positive regulation of metabolic process|extracellular space|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|regulation of membrane potential|cell development|neuronal cell body|transport|positive regulation of cellular component organization|terminal bouton|regulation of cell death|response to extracellular stimulus|multicellular organism development|neurological system process|receptor binding|secretion by cell|defense response|positive regulation of ion transport|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|positive regulation of cell death|regulation of appetite|behavioral fear response|regulation of membrane depolarization|movement of cell or subcellular component|homeostatic process|neuron projection|perikaryon|somatodendritic compartment|positive regulation of mitochondrial depolarization|positive regulation of catalytic activity|cell communication|multicellular organismal response to stress|cell migration|signal transduction|regulation of ion homeostasis|neuron projection terminus|cell death|positive regulation of secretion|regulation of catalytic activity|cell projection organization|cellular developmental process|response to food|eating behavior|protein metabolic process|positive regulation of protein complex assembly|regulation of protein complex assembly|regulation of cellular metabolic process|organelle organization|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|G-protein coupled receptor signaling pathway|negative regulation of appetite|membrane depolarization|regulation of mitochondrial depolarization|axon|macromolecule modification|positive regulation of hydrolase activity|fear response|mitochondrion organization|chemical homeostasis|hormone activity|protein maturation|positive regulation of protein oligomerization|positive regulation of amino acid transport|axon initial segment|cell morphogenesis involved in differentiation|protein modification process|neuron migration|ion transport|main axon|axon terminus|sensory perception|regulation of secretion|regulation of protein oligomerization|dendrite|regulation of neurological system process|positive regulation of protein metabolic process|proteolysis|protein complex assembly|regulation of response to food|regulation of mitochondrial membrane potential|regulation of ion transport|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|nervous system development|secretion|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|response to nutrient levels|axon hillock|glutamate secretion|positive regulation of glutamate secretion|regulation of programmed cell death|amine transport|apoptotic signaling pathway|neuron development|neuron differentiation|anion transport|organic anion transport|regulation of glutamate secretion|neuropeptide hormone activity|positive regulation of protein modification process|positive regulation of apoptotic process|sensory perception of pain|protein oligomerization|protein processing|regulation of proteolysis|apoptotic mitochondrial changes|positive regulation of proteolysis|mitochondrial depolarization|phosphorylation|regulation of peptidase activity|axon development|carboxylic acid transport|release of cytochrome c from mitochondria|regulation of apoptotic process|regulation of anion transport|ion homeostasis|amino acid transport|neurogenesis|cell morphogenesis involved in neuron differentiation|cellular protein modification process|neuron projection morphogenesis|positive regulation of peptidase activity|acid secretion|protein kinase C-activating G-protein coupled receptor signaling pathway|apoptotic process|positive regulation of endopeptidase activity|regulation of sensory perception of pain|axonogenesis|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|generation of neurons|dicarboxylic acid transport|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|zymogen activation|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of protein phosphorylation|activation of cysteine-type endopeptidase activity involved in apoptotic process|positive regulation of phosphorylation|regulation of endopeptidase activity|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|positive regulation of cysteine-type endopeptidase activity|regulation of cysteine-type endopeptidase activity|activation of cysteine-type endopeptidase activity|peptidyl-tyrosine phosphorylation - - - - 3:42257825-42266207 8 6 2 0 0 2 0.189697788664204 0.12930734578425 0.042761013742349 0 0 0.044442336827166 0.120588716063601 0.014814112275722 3.02505083358033 0.00480379935594967 0.0226238564398993 UP ENSG00000198785 GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A [Source:HGNC Symbol;Acc:HGNC:16767] GO:0032502|GO:0032991|GO:0004871|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0042995|GO:0004872|GO:0022857|GO:0050794|GO:0060076|GO:0043229|GO:0043167|GO:0038023|GO:0044297|GO:0016043|GO:0071944|GO:0009605|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0048856|GO:0097060|GO:0042802|GO:0030594|GO:0048468|GO:0043025|GO:0006810|GO:0098797|GO:0007275|GO:0050877|GO:0016358|GO:0043168|GO:0001964|GO:0045211|GO:0005887|GO:0043169|GO:0019899|GO:0004888|GO:0043235|GO:0043177|GO:0043005|GO:0036477|GO:0014069|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0030030|GO:0048869|GO:0016021|GO:0010033|GO:0031175|GO:0008328|GO:0050905|GO:0007166|GO:0015267|GO:0006811|GO:0019902|GO:0015075|GO:0008066|GO:0034702|GO:0031406|GO:0060134|GO:0007399|GO:0030154|GO:0016594|GO:0097305|GO:0034220|GO:0048666|GO:0030182|GO:0015276|GO:0098655|GO:0005216|GO:0022824|GO:0007215|GO:0017146|GO:0006812|GO:0004970|GO:0019903|GO:0045471|GO:0016597|GO:0022008|GO:0008324|GO:0004972|GO:0035235|GO:0048699|GO:0005230|GO:0022890|GO:0030001|GO:0005261|GO:0051721|GO:0005262|GO:0070588|GO:0005231|GO:0046873|GO:0005234|GO:0006816|GO:0015085 developmental process|macromolecular complex|signal transducer activity|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|small molecule binding|cellular response to stimulus|cell projection|receptor activity|transmembrane transporter activity|regulation of cellular process|excitatory synapse|intracellular organelle|ion binding|signaling receptor activity|cell body|cellular component organization|cell periphery|response to external stimulus|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|anatomical structure development|synaptic membrane|identical protein binding|neurotransmitter receptor activity|cell development|neuronal cell body|transport|plasma membrane protein complex|multicellular organism development|neurological system process|dendrite development|anion binding|startle response|postsynaptic membrane|integral component of plasma membrane|cation binding|enzyme binding|transmembrane signaling receptor activity|receptor complex|organic acid binding|neuron projection|somatodendritic compartment|postsynaptic density|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|cell projection organization|cellular developmental process|integral component of membrane|response to organic substance|neuron projection development|ionotropic glutamate receptor complex|neuromuscular process|cell surface receptor signaling pathway|channel activity|ion transport|phosphatase binding|ion transmembrane transporter activity|glutamate receptor activity|ion channel complex|carboxylic acid binding|prepulse inhibition|nervous system development|cell differentiation|glycine binding|response to alcohol|ion transmembrane transport|neuron development|neuron differentiation|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|transmitter-gated ion channel activity|glutamate receptor signaling pathway|NMDA selective glutamate receptor complex|cation transport|ionotropic glutamate receptor activity|protein phosphatase binding|response to ethanol|amino acid binding|neurogenesis|cation transmembrane transporter activity|NMDA glutamate receptor activity|ionotropic glutamate receptor signaling pathway|generation of neurons|extracellular ligand-gated ion channel activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|protein phosphatase 2A binding|calcium channel activity|calcium ion transmembrane transport|excitatory extracellular ligand-gated ion channel activity|metal ion transmembrane transporter activity|extracellular-glutamate-gated ion channel activity|calcium ion transport|calcium ion transmembrane transporter activity K05213 glutamate receptor ionotropic, NMDA 3A[-] hsa04080|hsa04024|hsa05034|hsa04724|hsa05031|hsa05030|hsa05033 Neuroactive ligand-receptor interaction - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Amphetamine addiction - Homo sapiens (human)|Cocaine addiction - Homo sapiens (human)|Nicotine addiction - Homo sapiens (human) 9:101569353-101738580 8 12 12 3 2 6 0.0684407962730189 0.0933052279812329 0.0925661132027772 0.0229935291139915 0.0140382600169051 0.048111391995248 0.0847707124856763 0.0283810603753815 1.57863742029606 0.00480900527680752 0.0226448018192132 UP ENSG00000273576 RP11-390P24.1 - - - - - - - 17:39566915-39567559 24 19 23 10 13 9 2.63204925845715 1.89378164986076 2.27420437480239 0.982648877625344 1.16972593876431 0.925026705658705 2.26667842770677 1.02580050734945 1.14382954135687 0.00483230916168003 0.0227401887945769 UP ENSG00000108950 FAM20A family with sequence similarity 20 member A [Source:HGNC Symbol;Acc:HGNC:23015] GO:0032502|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0050794|GO:0043229|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0048646|GO:0019222|GO:0044691|GO:0009888|GO:0007275|GO:0048513|GO:0008047|GO:0031982|GO:0031325|GO:0043231|GO:0005737|GO:0009887|GO:0042592|GO:0034505|GO:0043085|GO:0097186|GO:0005783|GO:0070062|GO:0050790|GO:0019207|GO:0019538|GO:0031323|GO:0005794|GO:0032268|GO:0043412|GO:0019887|GO:0048878|GO:0031214|GO:0051347|GO:0036211|GO:0070166|GO:0051247|GO:0032270|GO:0006796|GO:0042476|GO:0044267|GO:0051174|GO:0019209|GO:0051246|GO:0031401|GO:0016310|GO:0030295|GO:0050801|GO:0042475|GO:0006464|GO:0043549|GO:0033674|GO:0045859|GO:0045860|GO:0006468|GO:0043539|GO:0042325|GO:0001932|GO:0001934|GO:0042327|GO:0055065|GO:0071902|GO:0071900|GO:0055074 developmental process|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|regulation of cellular process|intracellular organelle|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|protein binding|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|tooth eruption|tissue development|multicellular organism development|animal organ development|enzyme activator activity|vesicle|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cytoplasm|organ morphogenesis|homeostatic process|tooth mineralization|positive regulation of catalytic activity|amelogenesis|endoplasmic reticulum|extracellular exosome|regulation of catalytic activity|kinase regulator activity|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of cellular protein metabolic process|macromolecule modification|protein kinase regulator activity|chemical homeostasis|biomineral tissue development|positive regulation of transferase activity|protein modification process|enamel mineralization|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|odontogenesis|cellular protein metabolic process|regulation of phosphorus metabolic process|kinase activator activity|regulation of protein metabolic process|positive regulation of protein modification process|phosphorylation|protein kinase activator activity|ion homeostasis|odontogenesis of dentin-containing tooth|cellular protein modification process|regulation of kinase activity|positive regulation of kinase activity|regulation of protein kinase activity|positive regulation of protein kinase activity|protein phosphorylation|protein serine/threonine kinase activator activity|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of phosphorylation|metal ion homeostasis|positive regulation of protein serine/threonine kinase activity|regulation of protein serine/threonine kinase activity|calcium ion homeostasis - - - - 17:68535113-68601389 6 15 23 3 5 7 0.0355742982136622 0.0808331899282407 0.122955726885796 0.0159354986349104 0.0243252217287423 0.0388994748025506 0.0797877383425663 0.0263867317220678 1.59635438374369 0.00486447423228975 0.0228627225646691 UP ENSG00000162572 SCNN1D sodium channel, non voltage gated 1 delta subunit [Source:HGNC Symbol;Acc:HGNC:10601] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0004872|GO:0022857|GO:0043229|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0006810|GO:0050877|GO:0022891|GO:0055085|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0007600|GO:0005856|GO:0034220|GO:0015629|GO:0015276|GO:0098655|GO:0005216|GO:0006812|GO:0007606|GO:0008324|GO:0050909|GO:0015280|GO:0022890|GO:0030001|GO:0005261|GO:0015672|GO:0005272|GO:0035725|GO:0006814|GO:0015077|GO:0046873|GO:0015081 transporter activity|cell|membrane|cellular process|response to stimulus|binding|receptor activity|transmembrane transporter activity|intracellular organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|transport|neurological system process|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|sensory perception|cytoskeleton|ion transmembrane transport|actin cytoskeleton|ligand-gated ion channel activity|cation transmembrane transport|ion channel activity|cation transport|sensory perception of chemical stimulus|cation transmembrane transporter activity|sensory perception of taste|ligand-gated sodium channel activity|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|monovalent inorganic cation transport|sodium channel activity|sodium ion transmembrane transport|sodium ion transport|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|sodium ion transmembrane transporter activity - - - - 1:1280436-1292029 49 26 72 18 16 33 0.472801832878507 0.228000252906262 0.62636560456362 0.155611953172961 0.126668229696782 0.298419269467508 0.44238923011613 0.193566484112417 1.19248709115484 0.00488084021484407 0.0229288125529434 UP ENSG00000157703 SVOPL SVOP-like [Source:HGNC Symbol;Acc:HGNC:27034] GO:0005215|GO:0016020|GO:0009987|GO:0022857|GO:0031224|GO:0006810|GO:0022891|GO:0055085|GO:0016021 transporter activity|membrane|cellular process|transmembrane transporter activity|intrinsic component of membrane|transport|substrate-specific transmembrane transporter activity|transmembrane transport|integral component of membrane - - - - 7:138594285-138701352 9 10 11 23 21 36 0.082178287983469 0.0829834801588608 0.0905544336887801 0.188166716258058 0.157326021315477 0.308063624706268 0.0852387339437033 0.217852120759934 -1.35376808780407 0.00488208949082146 0.0229310729482353 DOWN ENSG00000272980 RP11-517H2.6 - - - - - - - 6:166999405-167139141 1 4 6 8 10 26 0.0133270609082135 0.0484273461989224 0.0720655954765125 0.0954890434754572 0.109303162042899 0.324602811689619 0.0446066675278828 0.176465005735992 -1.9840508387072 0.00490044908028817 0.0230028312646106 DOWN ENSG00000224781 EIF4A2P4 eukaryotic translation initiation factor 4A2 pseudogene 4 [Source:HGNC Symbol;Acc:HGNC:45101] - - - - - - X:52832704-52833899 32 26 32 17 10 18 1.89264760555107 1.39755004519716 1.70638036416479 0.900871601346294 0.485284105725578 0.997729473494757 1.66552600497101 0.79462839352221 1.06762563036481 0.00491123862201089 0.0230498534540973 UP ENSG00000229238 PPP1R12BP1 protein phosphatase 1 regulatory subunit 12B pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:18498] - - - - - - Y:26277923-26354418 1 1 0 4 8 4 0.0423499062971956 0.0384905605846435 0 0.151719575360466 0.277876395348905 0.158673238486459 0.0269468222939464 0.19608973639861 -2.86332696670182 0.00494952512815282 0.0232076524541973 DOWN ENSG00000120738 EGR1 early growth response 1 [Source:HGNC Symbol;Acc:HGNC:3238] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0009628|GO:0044237|GO:0023051|GO:0007155|GO:0043227|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:0016337|GO:0045087|GO:0006725|GO:0001822|GO:0009888|GO:0009314|GO:1901360|GO:0001568|GO:0010941|GO:0032835|GO:0007275|GO:0003676|GO:0048513|GO:0070489|GO:0034641|GO:0006952|GO:0031325|GO:0046483|GO:0033554|GO:0098609|GO:0061061|GO:0043231|GO:0072111|GO:0043169|GO:0019899|GO:0010243|GO:0005737|GO:0000981|GO:0001775|GO:0009966|GO:0072006|GO:0009890|GO:0010646|GO:0006139|GO:0046649|GO:0007154|GO:0007165|GO:0009968|GO:0009725|GO:0008219|GO:0001666|GO:0048869|GO:0044249|GO:0090184|GO:0019538|GO:0010033|GO:0031324|GO:0031323|GO:0000982|GO:1901724|GO:0032268|GO:0030111|GO:0003677|GO:0009743|GO:0034340|GO:0010468|GO:0071773|GO:0034645|GO:0030178|GO:0046872|GO:0007166|GO:0001944|GO:0043412|GO:0030097|GO:0072358|GO:0034097|GO:0030098|GO:0001655|GO:0010629|GO:0043620|GO:0035035|GO:0072210|GO:0072110|GO:0051252|GO:0072126|GO:1901652|GO:0072203|GO:0071417|GO:0001656|GO:0010628|GO:0036211|GO:0071456|GO:0060537|GO:0072001|GO:0031981|GO:0043434|GO:0072012|GO:0071478|GO:0007159|GO:0070848|GO:0005654|GO:0071453|GO:0090193|GO:0042110|GO:0012501|GO:0014070|GO:1901342|GO:0010212|GO:0044267|GO:0010467|GO:0072224|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0030154|GO:0071503|GO:0061448|GO:0001228|GO:0007517|GO:0016070|GO:0072359|GO:0010557|GO:0005634|GO:0043067|GO:0002521|GO:0016055|GO:0060538|GO:0000975|GO:0045893|GO:0010332|GO:0072239|GO:0019221|GO:0070555|GO:0090090|GO:0060828|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:0071504|GO:0030217|GO:0034284|GO:0001077|GO:0071363|GO:0071357|GO:0061418|GO:1902679|GO:0071407|GO:0070486|GO:0003690|GO:0072262|GO:0030509|GO:0007167|GO:0072300|GO:0035914|GO:0042981|GO:0071345|GO:0071506|GO:0032868|GO:0071479|GO:0072303|GO:0014706|GO:0006464|GO:0006351|GO:0006915|GO:0006355|GO:0043618|GO:0036294|GO:0045944|GO:0006366|GO:1903507|GO:0071347|GO:0006357|GO:0007519|GO:0071480|GO:1903506|GO:0044212|GO:0060070|GO:0018193|GO:0007178|GO:0000122|GO:0071593|GO:0060337|GO:0070498|GO:0032446|GO:0000976|GO:0001012|GO:0009749|GO:0033233|GO:0018205|GO:0016925|GO:0000977 developmental process|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|response to abiotic stimulus|cellular metabolic process|regulation of signaling|cell adhesion|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|immune system development|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|single organismal cell-cell adhesion|innate immune response|cellular aromatic compound metabolic process|kidney development|tissue development|response to radiation|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|glomerulus development|multicellular organism development|nucleic acid binding|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|cellular response to stress|cell-cell adhesion|muscle structure development|intracellular membrane-bounded organelle|cell proliferation involved in kidney development|cation binding|enzyme binding|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|cell activation|regulation of signal transduction|nephron development|negative regulation of biosynthetic process|regulation of cell communication|nucleobase-containing compound metabolic process|lymphocyte activation|cell communication|signal transduction|negative regulation of signal transduction|response to hormone|cell death|response to hypoxia|cellular developmental process|cellular biosynthetic process|positive regulation of kidney development|protein metabolic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|positive regulation of cell proliferation involved in kidney development|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|DNA binding|response to carbohydrate|response to type I interferon|regulation of gene expression|cellular response to BMP stimulus|cellular macromolecule biosynthetic process|negative regulation of Wnt signaling pathway|metal ion binding|cell surface receptor signaling pathway|vasculature development|macromolecule modification|hemopoiesis|cardiovascular system development|response to cytokine|lymphocyte differentiation|urogenital system development|negative regulation of gene expression|regulation of DNA-templated transcription in response to stress|histone acetyltransferase binding|metanephric nephron development|glomerular mesangial cell proliferation|regulation of RNA metabolic process|positive regulation of glomerular mesangial cell proliferation|response to peptide|cell proliferation involved in metanephros development|cellular response to organonitrogen compound|metanephros development|positive regulation of gene expression|protein modification process|cellular response to hypoxia|muscle tissue development|renal system development|nuclear lumen|response to peptide hormone|glomerulus vasculature development|cellular response to radiation|leukocyte cell-cell adhesion|response to growth factor|nucleoplasm|cellular response to oxygen levels|positive regulation of glomerulus development|T cell activation|programmed cell death|response to organic cyclic compound|regulation of vasculature development|response to ionizing radiation|cellular protein metabolic process|gene expression|metanephric glomerulus development|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|response to heparin|connective tissue development|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding|muscle organ development|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|nucleus|regulation of programmed cell death|leukocyte differentiation|Wnt signaling pathway|skeletal muscle organ development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|response to gamma radiation|metanephric glomerulus vasculature development|cytokine-mediated signaling pathway|response to interleukin-1|negative regulation of canonical Wnt signaling pathway|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|cellular response to heparin|T cell differentiation|response to monosaccharide|transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding|cellular response to growth factor stimulus|cellular response to type I interferon|regulation of transcription from RNA polymerase II promoter in response to hypoxia|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|leukocyte aggregation|double-stranded DNA binding|metanephric glomerular mesangial cell proliferation involved in metanephros development|BMP signaling pathway|enzyme linked receptor protein signaling pathway|positive regulation of metanephric glomerulus development|skeletal muscle cell differentiation|regulation of apoptotic process|cellular response to cytokine stimulus|cellular response to mycophenolic acid|response to insulin|cellular response to ionizing radiation|positive regulation of glomerular metanephric mesangial cell proliferation|striated muscle tissue development|cellular protein modification process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|regulation of transcription from RNA polymerase II promoter in response to stress|cellular response to decreased oxygen levels|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|cellular response to interleukin-1|regulation of transcription from RNA polymerase II promoter|skeletal muscle tissue development|cellular response to gamma radiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|canonical Wnt signaling pathway|peptidyl-amino acid modification|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|lymphocyte aggregation|type I interferon signaling pathway|interleukin-1-mediated signaling pathway|protein modification by small protein conjugation|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|response to glucose|regulation of protein sumoylation|peptidyl-lysine modification|protein sumoylation|RNA polymerase II regulatory region sequence-specific DNA binding K09203 early growth response protein 1[-] hsa05166|hsa04933|hsa05020 HTLV-I infection - Homo sapiens (human)|AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)|Prion diseases - Homo sapiens (human) 5:138465490-138469315 177 194 543 473 468 1302 3.9899311216988 3.97442211706166 11.0358767149267 9.55326623669411 8.65578393785609 27.5063416384165 6.33340998456239 15.2384639376556 -1.26666310570042 0.00497116217719547 0.0232908153857491 DOWN ENSG00000151692 RNF144A ring finger protein 144A [Source:HGNC Symbol;Acc:HGNC:20457] GO:0032991|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0050794|GO:0043229|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0071944|GO:0009893|GO:0031224|GO:0016874|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0016740|GO:0031090|GO:0019222|GO:0031982|GO:0031325|GO:0043231|GO:0043169|GO:0019899|GO:0005737|GO:0012506|GO:0019787|GO:0000151|GO:0016021|GO:0019538|GO:0031323|GO:0005794|GO:0032268|GO:0045732|GO:0046872|GO:0043412|GO:0030163|GO:0031410|GO:0004842|GO:0044265|GO:0016023|GO:0036211|GO:1990234|GO:0051247|GO:0006508|GO:0031988|GO:0032270|GO:0030659|GO:0044267|GO:0044390|GO:0042176|GO:0051246|GO:0044257|GO:0061630|GO:0010498|GO:1903364|GO:0030162|GO:0045862|GO:0051603|GO:0046914|GO:0031624|GO:0006464|GO:1903052|GO:0019941|GO:1901800|GO:0061136|GO:0008270|GO:0043161|GO:0032446|GO:0006511|GO:0032434|GO:0032436|GO:0042787|GO:0016567|GO:0000209 macromolecular complex|cell|membrane|cellular process|metabolic process|binding|catalytic activity|regulation of cellular process|intracellular organelle|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|intrinsic component of membrane|ligase activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|transferase activity|organelle membrane|regulation of metabolic process|vesicle|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|enzyme binding|cytoplasm|vesicle membrane|ubiquitin-like protein transferase activity|ubiquitin ligase complex|integral component of membrane|protein metabolic process|regulation of cellular metabolic process|Golgi apparatus|regulation of cellular protein metabolic process|positive regulation of protein catabolic process|metal ion binding|macromolecule modification|protein catabolic process|cytoplasmic vesicle|ubiquitin-protein transferase activity|cellular macromolecule catabolic process|cytoplasmic, membrane-bounded vesicle|protein modification process|transferase complex|positive regulation of protein metabolic process|proteolysis|membrane-bounded vesicle|positive regulation of cellular protein metabolic process|cytoplasmic vesicle membrane|cellular protein metabolic process|ubiquitin-like protein conjugating enzyme binding|regulation of protein catabolic process|regulation of protein metabolic process|cellular protein catabolic process|ubiquitin protein ligase activity|proteasomal protein catabolic process|positive regulation of cellular protein catabolic process|regulation of proteolysis|positive regulation of proteolysis|proteolysis involved in cellular protein catabolic process|transition metal ion binding|ubiquitin conjugating enzyme binding|cellular protein modification process|positive regulation of proteolysis involved in cellular protein catabolic process|modification-dependent protein catabolic process|positive regulation of proteasomal protein catabolic process|regulation of proteasomal protein catabolic process|zinc ion binding|proteasome-mediated ubiquitin-dependent protein catabolic process|protein modification by small protein conjugation|ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein ubiquitination|protein polyubiquitination - - - - 2:6917392-7068286 12 9 32 30 52 56 0.114325793444697 0.0779281001171037 0.274859382564457 0.256075617507474 0.406465880768996 0.499999374869364 0.155704425375419 0.387513624381945 -1.3154370854518 0.00497454258131063 0.0233029961121054 DOWN ENSG00000197816 CCDC180 coiled-coil domain containing 180 [Source:HGNC Symbol;Acc:HGNC:29303] GO:0016020|GO:0005576|GO:1903561|GO:0043227|GO:0031224|GO:0031982|GO:0070062|GO:0016021 membrane|extracellular region|extracellular vesicle|membrane-bounded organelle|intrinsic component of membrane|vesicle|extracellular exosome|integral component of membrane - - - - 9:97307304-97378524 7 8 26 36 37 33 0.0239581996860656 0.024883801849843 0.0802284983336952 0.110395131393168 0.103900207036874 0.105850186978242 0.0430234999565346 0.106715175136095 -1.31056854749012 0.00499592864071636 0.0233884982969964 DOWN ENSG00000255893 RP11-685N10.1 - - - - - - - 11:94472908-94473570 4 1 6 10 12 19 0.486978058162926 0.110701767189224 0.658637370017695 1.09089247171833 1.19874031715587 2.16793493231919 0.418772398456615 1.48585590706446 -1.82705595370155 0.00503417030818641 0.0235379984934373 DOWN ENSG00000177721 ANXA2R annexin A2 receptor [Source:HGNC Symbol;Acc:HGNC:33463] GO:0004872 receptor activity - - - - 5:43039081-43043170 31 21 38 14 16 16 0.626704727869809 0.385842746018385 0.692626243932945 0.253595866389164 0.265391480968021 0.303147459143839 0.568391239273713 0.274044935500341 1.05247184506598 0.00504995782555401 0.0236007265065888 UP ENSG00000270115 RP11-415J8.7 - - - - - - - 1:33261212-33261680 0 0 1 3 3 8 0 0 0.135916157398389 0.405352875723841 0.371282646917109 1.13082405068688 0.045305385799463 0.635819857775943 -3.81086360526284 0.00505606224169131 0.0236255567637271 DOWN ENSG00000225411 RP11-764K9.1 - - - - - - - 9:63802144-63814159 0 1 0 3 3 8 0 0.0223480634944195 0 0.066056462374733 0.060504364629647 0.184279527370447 0.00744935449813983 0.103613451458276 -3.79795208213706 0.00506222192038353 0.0236506374352316 DOWN ENSG00000120471 TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 [Source:HGNC Symbol;Acc:HGNC:29984] GO:0005623|GO:0009987|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0008219|GO:0005739|GO:0012501|GO:0006915 cell|cellular process|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|cell death|mitochondrion|programmed cell death|apoptotic process K13773 p53-regulated apoptosis-inducing protein 1[-] hsa04210|hsa04115 Apoptosis - Homo sapiens (human)|p53 signaling pathway - Homo sapiens (human) 11:128934731-128943399 8 15 7 2 4 4 0.063487995465648 0.108194766727691 0.0500856041512539 0.0142221143513597 0.0260447287826257 0.0297478942568016 0.073922788781531 0.023338245796929 1.66332305836856 0.00507494061965471 0.0237063491252029 UP ENSG00000136688 IL36G interleukin 36, gamma [Source:HGNC Symbol;Acc:HGNC:15741] GO:0002376|GO:0023052|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006950|GO:0006955|GO:0005615|GO:0005515|GO:0045087|GO:0005102|GO:0006952|GO:0002437|GO:0007267|GO:0007154|GO:0007165|GO:0010033|GO:0005126|GO:0007166|GO:0070851|GO:0034097|GO:0005125|GO:0006954|GO:0071310|GO:0019221|GO:0071345|GO:0005149 immune system process|signaling|cellular process|extracellular region|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|response to stress|immune response|extracellular space|protein binding|innate immune response|receptor binding|defense response|inflammatory response to antigenic stimulus|cell-cell signaling|cell communication|signal transduction|response to organic substance|cytokine receptor binding|cell surface receptor signaling pathway|growth factor receptor binding|response to cytokine|cytokine activity|inflammatory response|cellular response to organic substance|cytokine-mediated signaling pathway|cellular response to cytokine stimulus|interleukin-1 receptor binding - - - - 2:112973203-112985665 1 4 4 0 0 0 0.0312435732550172 0.113531659300785 0.112632321407 0 0 0 0.0858025179876007 0 Inf 0.00507958192363905 0.0237206067180229 UP ENSG00000231050 RP1-140A9.1 - - - - - - - 1:1891471-1892658 1 4 4 0 0 0 0.0781089331375429 0.283829148251962 0.281580803517499 0 0 0 0.214506294969001 0 Inf 0.00507898848236832 0.0237206067180229 UP ENSG00000163431 LMOD1 leiomodin 1 (smooth muscle) [Source:HGNC Symbol;Acc:HGNC:6647] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0048523|GO:0050794|GO:0043229|GO:0009653|GO:0016043|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0030017|GO:0048468|GO:0032535|GO:0051128|GO:0022607|GO:0061061|GO:0005737|GO:0032970|GO:0003012|GO:0008092|GO:0048869|GO:0030029|GO:0043254|GO:0006996|GO:0005829|GO:0031333|GO:0006936|GO:0032956|GO:0005865|GO:0007010|GO:0042692|GO:0005523|GO:0003779|GO:0043292|GO:0043242|GO:0006461|GO:0055001|GO:0043244|GO:0030036|GO:0070925|GO:0033043|GO:0030154|GO:0030832|GO:0030239|GO:0005856|GO:0055002|GO:0015629|GO:0043241|GO:0030016|GO:0034622|GO:0043623|GO:0008064|GO:0051494|GO:0051493|GO:0032272|GO:0051146|GO:1901879|GO:0031032|GO:0007015|GO:0030833|GO:0051258|GO:0043624|GO:0030837|GO:0030834|GO:0008154|GO:0030835|GO:0051693|GO:0030042|GO:0030041|GO:0051261|GO:0051694 developmental process|cell|membrane|cellular process|binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|anatomical structure morphogenesis|cellular component organization|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|sarcomere|cell development|regulation of cellular component size|regulation of cellular component organization|cellular component assembly|muscle structure development|cytoplasm|regulation of actin filament-based process|muscle system process|cytoskeletal protein binding|cellular developmental process|actin filament-based process|regulation of protein complex assembly|organelle organization|cytosol|negative regulation of protein complex assembly|muscle contraction|regulation of actin cytoskeleton organization|striated muscle thin filament|cytoskeleton organization|muscle cell differentiation|tropomyosin binding|actin binding|contractile fiber|negative regulation of protein complex disassembly|protein complex assembly|muscle cell development|regulation of protein complex disassembly|actin cytoskeleton organization|organelle assembly|regulation of organelle organization|cell differentiation|regulation of actin filament length|myofibril assembly|cytoskeleton|striated muscle cell development|actin cytoskeleton|protein complex disassembly|myofibril|cellular macromolecular complex assembly|cellular protein complex assembly|regulation of actin polymerization or depolymerization|negative regulation of cytoskeleton organization|regulation of cytoskeleton organization|negative regulation of protein polymerization|striated muscle cell differentiation|regulation of protein depolymerization|actomyosin structure organization|actin filament organization|regulation of actin filament polymerization|protein polymerization|cellular protein complex disassembly|negative regulation of actin filament polymerization|regulation of actin filament depolymerization|actin polymerization or depolymerization|negative regulation of actin filament depolymerization|actin filament capping|actin filament depolymerization|actin filament polymerization|protein depolymerization|pointed-end actin filament capping - - - - 1:201896452-201946588 48 74 111 17 31 60 0.483116611185219 0.676901017907106 1.00728470414782 0.153307119409529 0.256005190321399 0.565970167887863 0.722434111080048 0.325094159206264 1.15200837784914 0.00508241187898962 0.023729205552703 UP ENSG00000280186 RP11-483I13.6 - - - - - - - 1:108200413-108202743 1 4 4 0 0 0 0.0303589418372432 0.110317120684804 0.109443246669607 0 0 0 0.0833731030638847 0 Inf 0.00508380782190287 0.023729205552703 UP ENSG00000076641 PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 [Source:HGNC Symbol;Acc:HGNC:30043] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0002683|GO:0048523|GO:0050794|GO:0045321|GO:0006955|GO:0023051|GO:0007155|GO:0071944|GO:0031224|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0035591|GO:0002757|GO:0002250|GO:0016337|GO:0070489|GO:0030155|GO:0098609|GO:0001775|GO:0009966|GO:0030674|GO:0019904|GO:0010646|GO:0007162|GO:0050776|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0050778|GO:0002695|GO:0016021|GO:0009967|GO:0098857|GO:0051249|GO:0007166|GO:0034109|GO:0051250|GO:0002429|GO:0022408|GO:0022407|GO:0007159|GO:0002764|GO:0042110|GO:0035556|GO:0042169|GO:0045121|GO:0005070|GO:1903038|GO:0050863|GO:0050868|GO:0002768|GO:0070486|GO:0007167|GO:0034111|GO:0050851|GO:0050852|GO:0071593|GO:0007169|GO:0038127|GO:0007173 immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|binding, bridging|cellular response to stimulus|negative regulation of immune system process|negative regulation of cellular process|regulation of cellular process|leukocyte activation|immune response|regulation of signaling|cell adhesion|cell periphery|intrinsic component of membrane|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|signaling adaptor activity|immune response-activating signal transduction|adaptive immune response|single organismal cell-cell adhesion|T cell aggregation|regulation of cell adhesion|cell-cell adhesion|cell activation|regulation of signal transduction|protein binding, bridging|protein domain specific binding|regulation of cell communication|negative regulation of cell adhesion|regulation of immune response|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|positive regulation of immune response|negative regulation of leukocyte activation|integral component of membrane|positive regulation of signal transduction|membrane microdomain|regulation of lymphocyte activation|cell surface receptor signaling pathway|homotypic cell-cell adhesion|negative regulation of lymphocyte activation|immune response-activating cell surface receptor signaling pathway|negative regulation of cell-cell adhesion|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|immune response-regulating signaling pathway|T cell activation|intracellular signal transduction|SH2 domain binding|membrane raft|SH3/SH2 adaptor activity|negative regulation of leukocyte cell-cell adhesion|regulation of T cell activation|negative regulation of T cell activation|immune response-regulating cell surface receptor signaling pathway|leukocyte aggregation|enzyme linked receptor protein signaling pathway|negative regulation of homotypic cell-cell adhesion|antigen receptor-mediated signaling pathway|T cell receptor signaling pathway|lymphocyte aggregation|transmembrane receptor protein tyrosine kinase signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway - - - - 8:80967810-81112068 22 11 57 65 63 121 0.126530989983619 0.0574998575109874 0.295572716585256 0.33495366484382 0.297293606097488 0.652212572177373 0.159867854693287 0.42815328103956 -1.42124750204531 0.00510440607225409 0.0238080452201661 DOWN ENSG00000232324 AC008440.10 - - - - - - - 19:53864763-53866140 64 13 10 3 16 2 8.1570212820347 1.50588351655094 1.14915409003087 0.342541439125192 1.67316178722001 0.238867550910696 3.60401962953884 0.751523592418633 2.26171656872927 0.00510548353652788 0.0238080452201661 UP ENSG00000175728 C11orf44 chromosome 11 open reading frame 44 [Source:HGNC Symbol;Acc:HGNC:26805] - - - - - - 11:130672956-130717352 1 0 0 5 3 5 0.0199511399556284 0 0 0.0893352703490699 0.0490926307877429 0.0934590481079764 0.00665037998520947 0.0772956497482631 -3.53887854069765 0.00514532951747785 0.0239749689125243 DOWN ENSG00000184961 AL772307.1 - - - - - - - 9:39983821-39984401 1 0 0 4 6 3 0.121801537732554 0 0 0.43635698868733 0.599320140205361 0.342267187836754 0.040600512577518 0.459314772243148 -3.49991333699113 0.005146944236967 0.0239751713606511 DOWN ENSG00000149201 CCDC81 coiled-coil domain containing 81 [Source:HGNC Symbol;Acc:HGNC:26281] GO:0005623|GO:0043229|GO:0005622|GO:0005737|GO:0005813|GO:0005815|GO:0005856|GO:0015630 cell|intracellular organelle|intracellular|cytoplasm|centrosome|microtubule organizing center|cytoskeleton|microtubule cytoskeleton - - - - 11:86374736-86423109 4 4 1 9 14 12 0.034592768283734 0.0314401770774273 0.00779370067488012 0.0697390407574874 0.0993442301121573 0.0972612130190755 0.0246088820120138 0.0887814946295734 -1.85107987925708 0.00514795133446356 0.0239761215505578 DOWN ENSG00000266953 RP11-618P17.4 - GO:0009987|GO:0008152|GO:0003824|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0016853|GO:0009058|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0019637|GO:0046483|GO:0005975|GO:0051186|GO:0006139|GO:0016860|GO:0055086|GO:0006091|GO:0019693|GO:0009116|GO:0005996|GO:0016052|GO:0006796|GO:0016051|GO:0006757|GO:0019318|GO:0009259|GO:0009117|GO:0004347|GO:0016310|GO:0009132|GO:0006163|GO:0019752|GO:0006096|GO:0042278|GO:0019319|GO:0046939|GO:0006006|GO:0032787|GO:0006165|GO:0046034|GO:0046031|GO:0006094|GO:0006090 cellular process|metabolic process|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|isomerase activity|biosynthetic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|organophosphate metabolic process|heterocycle metabolic process|carbohydrate metabolic process|cofactor metabolic process|nucleobase-containing compound metabolic process|intramolecular oxidoreductase activity|nucleobase-containing small molecule metabolic process|generation of precursor metabolites and energy|ribose phosphate metabolic process|nucleoside metabolic process|monosaccharide metabolic process|carbohydrate catabolic process|phosphate-containing compound metabolic process|carbohydrate biosynthetic process|ATP generation from ADP|hexose metabolic process|ribonucleotide metabolic process|nucleotide metabolic process|glucose-6-phosphate isomerase activity|phosphorylation|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|carboxylic acid metabolic process|glycolytic process|purine nucleoside metabolic process|hexose biosynthetic process|nucleotide phosphorylation|glucose metabolic process|monocarboxylic acid metabolic process|nucleoside diphosphate phosphorylation|ATP metabolic process|ADP metabolic process|gluconeogenesis|pyruvate metabolic process - - - - 19:34396315-34409364 36 22 34 18 14 15 2.42527694098261 1.34697204356146 2.06513049479478 1.0864678368676 0.773844245797462 0.9470735373015 1.94579315977962 0.935795206655521 1.05609361396652 0.00517054855268181 0.0240701008095685 UP ENSG00000019549 SNAI2 snail family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:11094] GO:0040011|GO:0032502|GO:0032991|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0000785|GO:0016043|GO:0043473|GO:0007155|GO:0043227|GO:1903828|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0060341|GO:0051272|GO:0042127|GO:1900181|GO:0016337|GO:0045595|GO:0006725|GO:0061037|GO:0009888|GO:0048468|GO:0009314|GO:0006810|GO:0070849|GO:0051130|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0016570|GO:0003676|GO:0045596|GO:0048513|GO:0050877|GO:0034641|GO:0044281|GO:0030155|GO:0031325|GO:0046483|GO:0051128|GO:2000147|GO:0033554|GO:0022607|GO:0001817|GO:0098609|GO:0045597|GO:0043231|GO:0043169|GO:0005737|GO:0000981|GO:0001763|GO:0001816|GO:0033627|GO:0031668|GO:0032880|GO:0006928|GO:0009887|GO:1901888|GO:0009966|GO:0048729|GO:0050673|GO:0045184|GO:0009890|GO:0003682|GO:0060548|GO:0032387|GO:0010646|GO:0006139|GO:0007162|GO:0000790|GO:0008104|GO:0007154|GO:0051270|GO:0006629|GO:0016477|GO:0007165|GO:0030278|GO:0009968|GO:0001503|GO:0051649|GO:0008219|GO:0030656|GO:0008285|GO:0090317|GO:0060688|GO:0045833|GO:0048869|GO:2000145|GO:0044249|GO:0019538|GO:0010033|GO:0051224|GO:0031324|GO:0031323|GO:0048732|GO:0003272|GO:0060021|GO:0006996|GO:0072089|GO:0071774|GO:0007584|GO:0051276|GO:0000982|GO:0070562|GO:0043518|GO:0032268|GO:0030111|GO:0000902|GO:1902230|GO:0003677|GO:0010468|GO:0060536|GO:0034645|GO:0045216|GO:0030178|GO:0051216|GO:0042308|GO:0046872|GO:0035921|GO:0007166|GO:0002009|GO:0033993|GO:0043412|GO:0072594|GO:0072358|GO:1900387|GO:0010629|GO:0032642|GO:0043069|GO:0031056|GO:2001234|GO:0051252|GO:0006066|GO:0006325|GO:0032386|GO:0003007|GO:0060973|GO:0051223|GO:0045667|GO:0015031|GO:0060693|GO:0010957|GO:0061138|GO:0022612|GO:0000904|GO:0031058|GO:0016573|GO:0030334|GO:0051055|GO:0036211|GO:0031670|GO:0033628|GO:0006933|GO:0070201|GO:0046907|GO:2000647|GO:0003705|GO:2000027|GO:0033273|GO:0001649|GO:0032602|GO:0032330|GO:0071364|GO:0034329|GO:0003273|GO:0022408|GO:0007600|GO:0022407|GO:2000810|GO:0007431|GO:0060485|GO:0031981|GO:2001020|GO:0045600|GO:0044344|GO:0071478|GO:0051247|GO:0045939|GO:0070848|GO:0070563|GO:0050678|GO:0005694|GO:0003198|GO:0000228|GO:0035272|GO:0050680|GO:0033629|GO:0034613|GO:0008202|GO:0032270|GO:0012501|GO:0032331|GO:0003197|GO:0014070|GO:0060429|GO:0010212|GO:0035556|GO:0006929|GO:0033043|GO:0044267|GO:0048864|GO:0010467|GO:0017038|GO:0008610|GO:0019216|GO:0071310|GO:0001227|GO:1902532|GO:0045598|GO:0046890|GO:0051246|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0030335|GO:0061035|GO:0031669|GO:1903827|GO:1902531|GO:0016070|GO:0072359|GO:0031667|GO:0043616|GO:0005634|GO:0043067|GO:0097305|GO:0006974|GO:0006606|GO:0030522|GO:0097190|GO:0072091|GO:0006766|GO:0010638|GO:2001252|GO:2001237|GO:0016055|GO:1904589|GO:0010837|GO:0048863|GO:0097193|GO:0033280|GO:0045444|GO:2001242|GO:0060317|GO:0033365|GO:0033157|GO:0031401|GO:0090090|GO:1901797|GO:0001078|GO:0051169|GO:0050954|GO:0060828|GO:0045892|GO:0035414|GO:0072331|GO:0042770|GO:0042359|GO:0070561|GO:0002062|GO:0032774|GO:2001240|GO:0043565|GO:0019218|GO:2001141|GO:0097192|GO:2001243|GO:0014031|GO:2001236|GO:0071363|GO:0006605|GO:0033044|GO:1902679|GO:0071407|GO:0035066|GO:0016482|GO:0006694|GO:0006886|GO:0060445|GO:0008630|GO:0071295|GO:0050810|GO:1901796|GO:0042981|GO:0035065|GO:0010894|GO:0043066|GO:0016568|GO:0048762|GO:0007435|GO:0071479|GO:0042306|GO:1900180|GO:0007219|GO:0006464|GO:0001837|GO:0071396|GO:0097191|GO:0007043|GO:0035411|GO:0002934|GO:0006351|GO:0003203|GO:0006915|GO:0006355|GO:0043516|GO:0010839|GO:0014033|GO:1903533|GO:0070830|GO:0014032|GO:0006366|GO:0006913|GO:1903507|GO:0007605|GO:0043297|GO:0006357|GO:2000209|GO:0035412|GO:1903506|GO:0060070|GO:2001239|GO:0018193|GO:0043276|GO:0050872|GO:1901985|GO:0000122|GO:2000811|GO:0030330|GO:0034504|GO:0046822|GO:0071305|GO:0051170|GO:0006473|GO:0018205|GO:0018394|GO:0006475|GO:0018393 locomotion|developmental process|macromolecular complex|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|chromatin|cellular component organization|pigmentation|cell adhesion|membrane-bounded organelle|negative regulation of cellular protein localization|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|regulation of cellular localization|positive regulation of cellular component movement|regulation of cell proliferation|negative regulation of protein localization to nucleus|single organismal cell-cell adhesion|regulation of cell differentiation|cellular aromatic compound metabolic process|negative regulation of cartilage development|tissue development|cell development|response to radiation|transport|response to epidermal growth factor|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|histone modification|nucleic acid binding|negative regulation of cell differentiation|animal organ development|neurological system process|cellular nitrogen compound metabolic process|small molecule metabolic process|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell motility|cellular response to stress|cellular component assembly|regulation of cytokine production|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|morphogenesis of a branching structure|cytokine production|cell adhesion mediated by integrin|cellular response to extracellular stimulus|regulation of protein localization|movement of cell or subcellular component|organ morphogenesis|regulation of cell junction assembly|regulation of signal transduction|tissue morphogenesis|epithelial cell proliferation|establishment of protein localization|negative regulation of biosynthetic process|chromatin binding|negative regulation of cell death|negative regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|negative regulation of cell adhesion|nuclear chromatin|protein localization|cell communication|regulation of cellular component movement|lipid metabolic process|cell migration|signal transduction|regulation of ossification|negative regulation of signal transduction|ossification|establishment of localization in cell|cell death|regulation of vitamin metabolic process|negative regulation of cell proliferation|negative regulation of intracellular protein transport|regulation of morphogenesis of a branching structure|negative regulation of lipid metabolic process|cellular developmental process|regulation of cell motility|cellular biosynthetic process|protein metabolic process|response to organic substance|negative regulation of protein transport|negative regulation of cellular metabolic process|regulation of cellular metabolic process|gland development|endocardial cushion formation|palate development|organelle organization|stem cell proliferation|response to fibroblast growth factor|response to nutrient|chromosome organization|transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding|regulation of vitamin D receptor signaling pathway|negative regulation of DNA damage response, signal transduction by p53 class mediator|regulation of cellular protein metabolic process|regulation of Wnt signaling pathway|cell morphogenesis|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|DNA binding|regulation of gene expression|cartilage morphogenesis|cellular macromolecule biosynthetic process|cell-cell junction organization|negative regulation of Wnt signaling pathway|cartilage development|negative regulation of protein import into nucleus|metal ion binding|desmosome disassembly|cell surface receptor signaling pathway|morphogenesis of an epithelium|response to lipid|macromolecule modification|establishment of protein localization to organelle|cardiovascular system development|negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter|negative regulation of gene expression|regulation of chemokine production|negative regulation of programmed cell death|regulation of histone modification|negative regulation of apoptotic signaling pathway|regulation of RNA metabolic process|alcohol metabolic process|chromatin organization|regulation of intracellular transport|heart morphogenesis|cell migration involved in heart development|regulation of protein transport|regulation of osteoblast differentiation|protein transport|regulation of branching involved in salivary gland morphogenesis|negative regulation of vitamin D biosynthetic process|morphogenesis of a branching epithelium|gland morphogenesis|cell morphogenesis involved in differentiation|positive regulation of histone modification|histone acetylation|regulation of cell migration|negative regulation of lipid biosynthetic process|protein modification process|cellular response to nutrient|regulation of cell adhesion mediated by integrin|negative regulation of cell adhesion involved in substrate-bound cell migration|regulation of establishment of protein localization|intracellular transport|negative regulation of stem cell proliferation|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|regulation of organ morphogenesis|response to vitamin|osteoblast differentiation|chemokine production|regulation of chondrocyte differentiation|cellular response to epidermal growth factor stimulus|cell junction assembly|cell migration involved in endocardial cushion formation|negative regulation of cell-cell adhesion|sensory perception|regulation of cell-cell adhesion|regulation of bicellular tight junction assembly|salivary gland development|mesenchyme development|nuclear lumen|regulation of response to DNA damage stimulus|positive regulation of fat cell differentiation|cellular response to fibroblast growth factor stimulus|cellular response to radiation|positive regulation of protein metabolic process|negative regulation of steroid metabolic process|response to growth factor|negative regulation of vitamin D receptor signaling pathway|regulation of epithelial cell proliferation|chromosome|epithelial to mesenchymal transition involved in endocardial cushion formation|nuclear chromosome|exocrine system development|negative regulation of epithelial cell proliferation|negative regulation of cell adhesion mediated by integrin|cellular protein localization|steroid metabolic process|positive regulation of cellular protein metabolic process|programmed cell death|negative regulation of chondrocyte differentiation|endocardial cushion development|response to organic cyclic compound|epithelium development|response to ionizing radiation|intracellular signal transduction|substrate-dependent cell migration|regulation of organelle organization|cellular protein metabolic process|stem cell development|gene expression|protein import|lipid biosynthetic process|regulation of lipid metabolic process|cellular response to organic substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|negative regulation of intracellular signal transduction|regulation of fat cell differentiation|regulation of lipid biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|positive regulation of cell migration|regulation of cartilage development|cellular response to nutrient levels|regulation of cellular protein localization|regulation of intracellular signal transduction|RNA metabolic process|circulatory system development|response to nutrient levels|keratinocyte proliferation|nucleus|regulation of programmed cell death|response to alcohol|cellular response to DNA damage stimulus|protein import into nucleus|intracellular receptor signaling pathway|apoptotic signaling pathway|regulation of stem cell proliferation|vitamin metabolic process|positive regulation of organelle organization|positive regulation of chromosome organization|negative regulation of extrinsic apoptotic signaling pathway|Wnt signaling pathway|regulation of protein import|regulation of keratinocyte proliferation|stem cell differentiation|intrinsic apoptotic signaling pathway|response to vitamin D|fat cell differentiation|regulation of intrinsic apoptotic signaling pathway|cardiac epithelial to mesenchymal transition|protein localization to organelle|regulation of intracellular protein transport|positive regulation of protein modification process|negative regulation of canonical Wnt signaling pathway|negative regulation of signal transduction by p53 class mediator|transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding|nuclear transport|sensory perception of mechanical stimulus|regulation of canonical Wnt signaling pathway|negative regulation of transcription, DNA-templated|negative regulation of catenin import into nucleus|signal transduction by p53 class mediator|signal transduction in response to DNA damage|vitamin D metabolic process|vitamin D receptor signaling pathway|chondrocyte differentiation|RNA biosynthetic process|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|sequence-specific DNA binding|regulation of steroid metabolic process|regulation of RNA biosynthetic process|extrinsic apoptotic signaling pathway in absence of ligand|negative regulation of intrinsic apoptotic signaling pathway|mesenchymal cell development|regulation of extrinsic apoptotic signaling pathway|cellular response to growth factor stimulus|protein targeting|regulation of chromosome organization|negative regulation of RNA biosynthetic process|cellular response to organic cyclic compound|positive regulation of histone acetylation|cytosolic transport|steroid biosynthetic process|intracellular protein transport|branching involved in salivary gland morphogenesis|intrinsic apoptotic signaling pathway in response to DNA damage|cellular response to vitamin|regulation of steroid biosynthetic process|regulation of signal transduction by p53 class mediator|regulation of apoptotic process|regulation of histone acetylation|negative regulation of steroid biosynthetic process|negative regulation of apoptotic process|chromatin modification|mesenchymal cell differentiation|salivary gland morphogenesis|cellular response to ionizing radiation|regulation of protein import into nucleus|regulation of protein localization to nucleus|Notch signaling pathway|cellular protein modification process|epithelial to mesenchymal transition|cellular response to lipid|extrinsic apoptotic signaling pathway|cell-cell junction assembly|catenin import into nucleus|desmosome organization|transcription, DNA-templated|endocardial cushion morphogenesis|apoptotic process|regulation of transcription, DNA-templated|regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of keratinocyte proliferation|neural crest cell differentiation|regulation of protein targeting|bicellular tight junction assembly|neural crest cell development|transcription from RNA polymerase II promoter|nucleocytoplasmic transport|negative regulation of nucleic acid-templated transcription|sensory perception of sound|apical junction assembly|regulation of transcription from RNA polymerase II promoter|regulation of anoikis|regulation of catenin import into nucleus|regulation of nucleic acid-templated transcription|canonical Wnt signaling pathway|regulation of extrinsic apoptotic signaling pathway in absence of ligand|peptidyl-amino acid modification|anoikis|white fat cell differentiation|positive regulation of protein acetylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of anoikis|DNA damage response, signal transduction by p53 class mediator|protein localization to nucleus|regulation of nucleocytoplasmic transport|cellular response to vitamin D|nuclear import|protein acetylation|peptidyl-lysine modification|peptidyl-lysine acetylation|internal protein amino acid acetylation|internal peptidyl-lysine acetylation K05706 snail 2[-] hsa04390|hsa04520 Hippo signaling pathway - Homo sapiens (human)|Adherens junction - Homo sapiens (human) 8:48917690-48921740 32 44 85 21 37 23 0.602503736023177 0.752898933052717 1.44289793687418 0.35426293469191 0.571575586648419 0.405851395778206 0.932766868650025 0.443896639039512 1.07129276039078 0.00517755809555726 0.0240952173631748 UP ENSG00000020181 ADGRA2 adhesion G protein-coupled receptor A2 [Source:HGNC Symbol;Acc:HGNC:17849] GO:0040011|GO:0032502|GO:0004871|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0048523|GO:0050794|GO:0040012|GO:0009986|GO:0050795|GO:0038023|GO:0048870|GO:0023051|GO:0040017|GO:0009653|GO:0071944|GO:0009605|GO:0023057|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0048514|GO:0051272|GO:0006935|GO:0045595|GO:0048468|GO:0001568|GO:0007275|GO:0010632|GO:2000147|GO:0090287|GO:0004888|GO:0050920|GO:0006928|GO:0009966|GO:0010646|GO:0090288|GO:0001525|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0009968|GO:0010634|GO:0048869|GO:0016021|GO:2000145|GO:0010033|GO:0007186|GO:0002040|GO:0090132|GO:0007166|GO:1902548|GO:0001944|GO:0072358|GO:0007417|GO:0030334|GO:0001667|GO:0060856|GO:0045765|GO:0070848|GO:1901342|GO:0007399|GO:0071310|GO:0010594|GO:0030154|GO:0030335|GO:0072359|GO:0004930|GO:1900747|GO:1900746|GO:0010595|GO:0071363|GO:0007167|GO:0090210|GO:0010631|GO:0035924|GO:0043542|GO:0007169|GO:0038084 locomotion|developmental process|signal transducer activity|behavior|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|cell surface|regulation of behavior|signaling receptor activity|cell motility|regulation of signaling|positive regulation of locomotion|anatomical structure morphogenesis|cell periphery|response to external stimulus|negative regulation of signaling|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|positive regulation of cellular component movement|chemotaxis|regulation of cell differentiation|cell development|blood vessel development|multicellular organism development|regulation of epithelial cell migration|positive regulation of cell motility|regulation of cellular response to growth factor stimulus|transmembrane signaling receptor activity|regulation of chemotaxis|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|negative regulation of cellular response to growth factor stimulus|angiogenesis|cell communication|regulation of cellular component movement|cell migration|signal transduction|negative regulation of signal transduction|positive regulation of epithelial cell migration|cellular developmental process|integral component of membrane|regulation of cell motility|response to organic substance|G-protein coupled receptor signaling pathway|sprouting angiogenesis|epithelium migration|cell surface receptor signaling pathway|negative regulation of cellular response to vascular endothelial growth factor stimulus|vasculature development|cardiovascular system development|central nervous system development|regulation of cell migration|ameboidal-type cell migration|establishment of blood-brain barrier|regulation of angiogenesis|response to growth factor|regulation of vasculature development|nervous system development|cellular response to organic substance|regulation of endothelial cell migration|cell differentiation|positive regulation of cell migration|circulatory system development|G-protein coupled receptor activity|negative regulation of vascular endothelial growth factor signaling pathway|regulation of vascular endothelial growth factor signaling pathway|positive regulation of endothelial cell migration|cellular response to growth factor stimulus|enzyme linked receptor protein signaling pathway|regulation of establishment of blood-brain barrier|epithelial cell migration|cellular response to vascular endothelial growth factor stimulus|endothelial cell migration|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor signaling pathway - - - - 8:37784191-37844896 9 9 14 58 9 46 0.0613683436483453 0.055775606648303 0.0860702456095999 0.354343668283432 0.0503505458707768 0.293955742348857 0.0677380653020827 0.232883318834355 -1.78156861759557 0.00519954426561172 0.0241862253826071 DOWN ENSG00000230637 CTA-246H3.8 - - - - - - - 22:25327252-25339975 2 1 1 9 8 4 0.213374247204118 0.0970101459079025 0.0961458187327971 0.860325210189276 0.700349105019638 0.399913999262251 0.135510070614939 0.653529438157055 -2.26985215210903 0.00520994959493123 0.0242233040347418 DOWN ENSG00000123201 GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene) [Source:HGNC Symbol;Acc:HGNC:4686] - - - - - - 13:50994511-51080862 10 9 15 32 20 36 0.13753366313079 0.112505569389363 0.186007662020967 0.39434632805885 0.225693458982432 0.464042173945063 0.14534896484704 0.361360653662115 -1.31391863171015 0.00523757353698171 0.0243327918414335 DOWN ENSG00000243479 MNX1-AS1 MNX1 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:48954] - - - - - - 7:157010805-157016426 19 14 19 41 43 34 1.29103825791507 0.864574667730041 1.16402460495743 2.49617558075135 2.39732418875833 2.16522325633432 1.10654584353418 2.35290767528133 -1.08838149001899 0.0052394877144 0.024334570632698 DOWN ENSG00000132141 CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) [Source:HGNC Symbol;Acc:HGNC:1621] GO:0032991|GO:0000003|GO:0005215|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0036094|GO:0097159|GO:0044702|GO:0043167|GO:0019953|GO:0016043|GO:0006457|GO:0032504|GO:0005622|GO:0005515|GO:0043234|GO:0048609|GO:0008565|GO:0006810|GO:0043168|GO:0001882|GO:0022607|GO:0005737|GO:0045184|GO:0005832|GO:0008104|GO:0007276|GO:0051082|GO:0000166|GO:0005829|GO:1901998|GO:0048232|GO:0035639|GO:0001883|GO:0015031|GO:0032549|GO:0006461|GO:0017076|GO:0007283|GO:0034622|GO:0005524|GO:0043623|GO:0030554|GO:0051131 macromolecular complex|reproduction|transporter activity|cell|cellular process|reproductive process|binding|small molecule binding|organic cyclic compound binding|single organism reproductive process|ion binding|sexual reproduction|cellular component organization|protein folding|multicellular organism reproduction|intracellular|protein binding|protein complex|multicellular organismal reproductive process|protein transporter activity|transport|anion binding|nucleoside binding|cellular component assembly|cytoplasm|establishment of protein localization|chaperonin-containing T-complex|protein localization|gamete generation|unfolded protein binding|nucleotide binding|cytosol|toxin transport|male gamete generation|purine ribonucleoside triphosphate binding|purine nucleoside binding|protein transport|ribonucleoside binding|protein complex assembly|purine nucleotide binding|spermatogenesis|cellular macromolecular complex assembly|ATP binding|cellular protein complex assembly|adenyl nucleotide binding|chaperone-mediated protein complex assembly - - - - 17:34927859-34981078 2 3 5 12 12 12 0.0241576376189088 0.0329392641555803 0.0544496048167177 0.129878796325481 0.118932398269734 0.135843487240953 0.0371821688637356 0.128218227278723 -1.78591853623117 0.0052446337134089 0.0243466482475679 DOWN ENSG00000169594 BNC1 basonuclin 1 [Source:HGNC Symbol;Acc:HGNC:1081] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0008284|GO:0042127|GO:0006725|GO:0009888|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0006139|GO:0044249|GO:0003677|GO:0034645|GO:0046872|GO:0060429|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0008544|GO:0006351 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nucleobase-containing compound metabolic process|cellular biosynthetic process|DNA binding|cellular macromolecule biosynthetic process|metal ion binding|epithelium development|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|epidermis development|transcription, DNA-templated - - - - 15:83255903-83284716 9 7 11 21 25 24 0.0797388773807533 0.0563679282579354 0.0878663824883492 0.166704138982654 0.181731131609537 0.199282244403362 0.0746577293756793 0.182572504998518 -1.29010597850813 0.0052846984554154 0.0245097697200515 DOWN ENSG00000269903 RP11-571M6.18 - - - - - - - 12:57814494-57814926 5 3 3 0 1 0 0.816861305347053 0.445478824238056 0.441803191254669 0 0.134095213820675 0 0.568047773613259 0.0446984046068917 3.66771702330661 0.00528898972790611 0.0245258619659691 UP ENSG00000268107 AC003005.4 - GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:57487718-57505381 7 4 0 0 0 0 0.485458893246671 0.252107066976743 0 0 0 0 0.245855320074471 0 Inf 0.00530316021227973 0.0245839355554968 UP ENSG00000228445 UGT1A2P UDP glucuronosyltransferase 1 family, polypeptide A2 pseudogene [Source:HGNC Symbol;Acc:HGNC:12534] - - - - - - 2:233747214-233748079 3 6 5 17 11 17 0.245073694363677 0.445408559439281 0.368195018252539 1.24415985590089 0.737188102405555 1.30138418582218 0.352892424018499 1.09424404804288 -1.63263417327024 0.0053079900640265 0.0246025051034695 DOWN ENSG00000268364 SMC5-AS1 SMC5 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:48718] - - - - - - 9:70193997-70258866 4 2 3 11 12 11 0.155629401426106 0.0707231045974362 0.105225952592559 0.383474873250363 0.383095777924952 0.401107654513367 0.110526152872034 0.389226101896227 -1.81622067917284 0.00531401912318272 0.0246266263432935 DOWN ENSG00000160183 TMPRSS3 transmembrane protease, serine 3 [Source:HGNC Symbol;Acc:HGNC:11877] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0004872|GO:0043229|GO:0042175|GO:0071704|GO:0044297|GO:0043227|GO:0016787|GO:0031224|GO:0016247|GO:0005622|GO:0005789|GO:0005515|GO:0012505|GO:0031090|GO:0043025|GO:0006810|GO:0050877|GO:0043231|GO:0008233|GO:0005737|GO:0042592|GO:0019725|GO:0036477|GO:0005783|GO:0017080|GO:0016021|GO:0019538|GO:0038024|GO:0017171|GO:0016192|GO:0048878|GO:0055082|GO:0007600|GO:0006508|GO:0008236|GO:0005044|GO:0004252|GO:0050954|GO:0004175|GO:0050801|GO:0006897|GO:0006873|GO:0007605|GO:0006898|GO:0030003|GO:0055065|GO:0006875|GO:0006883|GO:0055078 cell|membrane|cellular process|metabolic process|binding|catalytic activity|receptor activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cell body|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|channel regulator activity|intracellular|endoplasmic reticulum membrane|protein binding|endomembrane system|organelle membrane|neuronal cell body|transport|neurological system process|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|homeostatic process|cellular homeostasis|somatodendritic compartment|endoplasmic reticulum|sodium channel regulator activity|integral component of membrane|protein metabolic process|cargo receptor activity|serine hydrolase activity|vesicle-mediated transport|chemical homeostasis|cellular chemical homeostasis|sensory perception|proteolysis|serine-type peptidase activity|scavenger receptor activity|serine-type endopeptidase activity|sensory perception of mechanical stimulus|endopeptidase activity|ion homeostasis|endocytosis|cellular ion homeostasis|sensory perception of sound|receptor-mediated endocytosis|cellular cation homeostasis|metal ion homeostasis|cellular metal ion homeostasis|cellular sodium ion homeostasis|sodium ion homeostasis - - - - 21:42371890-42396846 17 28 41 8 12 19 0.160913113956009 0.2408730708168 0.349899639948434 0.0678505045971735 0.0931979291138181 0.16854947085206 0.250561941573748 0.109865968187684 1.18942272723636 0.00531695716736327 0.0246364177051782 UP ENSG00000267102 RP11-686D22.7 - - - - - - - 17:35409602-35410228 3 1 2 8 9 10 0.338490939902622 0.1025801064385 0.203438762349963 0.808687114600762 0.833072668043762 1.05730138840125 0.214836602897028 0.899687057015258 -2.06618345415059 0.00532497784679635 0.0246620987648554 DOWN ENSG00000167476 JSRP1 junctional sarcoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:24963] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0048523|GO:0050794|GO:0043229|GO:0042175|GO:0051641|GO:0023051|GO:0043227|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0060341|GO:0051282|GO:0006810|GO:0033017|GO:0043231|GO:0005737|GO:0003012|GO:0042592|GO:0009966|GO:0019725|GO:0010646|GO:0007154|GO:0055085|GO:0007165|GO:0005783|GO:0051649|GO:2000021|GO:0051238|GO:0010469|GO:0006936|GO:0016528|GO:0048878|GO:0032386|GO:0051208|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0051279|GO:0034765|GO:0043269|GO:0035556|GO:0010522|GO:1902531|GO:0050881|GO:0060314|GO:0016529|GO:0022898|GO:0034220|GO:0006941|GO:0098655|GO:0003009|GO:0006812|GO:0060402|GO:0016482|GO:0032412|GO:0050801|GO:0019932|GO:0050848|GO:0006873|GO:0090279|GO:1903169|GO:1901019|GO:0030001|GO:0019722|GO:0051924|GO:2001257|GO:0030003|GO:0070588|GO:0055065|GO:0097553|GO:0006875|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|cellular localization|regulation of signaling|membrane-bounded organelle|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|regulation of cellular localization|regulation of sequestering of calcium ion|transport|sarcoplasmic reticulum membrane|intracellular membrane-bounded organelle|cytoplasm|muscle system process|homeostatic process|regulation of signal transduction|cellular homeostasis|regulation of cell communication|cell communication|transmembrane transport|signal transduction|endoplasmic reticulum|establishment of localization in cell|regulation of ion homeostasis|sequestering of metal ion|regulation of receptor activity|muscle contraction|sarcoplasm|chemical homeostasis|regulation of intracellular transport|sequestering of calcium ion|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|regulation of release of sequestered calcium ion into cytosol|regulation of ion transmembrane transport|regulation of ion transport|intracellular signal transduction|regulation of calcium ion transport into cytosol|regulation of intracellular signal transduction|musculoskeletal movement|regulation of ryanodine-sensitive calcium-release channel activity|sarcoplasmic reticulum|regulation of transmembrane transporter activity|ion transmembrane transport|striated muscle contraction|cation transmembrane transport|skeletal muscle contraction|cation transport|calcium ion transport into cytosol|cytosolic transport|regulation of ion transmembrane transporter activity|ion homeostasis|second-messenger-mediated signaling|regulation of calcium-mediated signaling|cellular ion homeostasis|regulation of calcium ion import|regulation of calcium ion transmembrane transport|regulation of calcium ion transmembrane transporter activity|metal ion transport|calcium-mediated signaling|regulation of calcium ion transport|regulation of cation channel activity|cellular cation homeostasis|calcium ion transmembrane transport|metal ion homeostasis|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration - - - - 19:2252252-2269759 19 33 28 13 16 12 0.625102709995156 0.986749485240541 0.830566840722902 0.383218151061781 0.431909205538189 0.369999749433962 0.814139678652866 0.395042368677977 1.04326894104856 0.00532583239787848 0.0246622305578198 UP ENSG00000279518 AC083843.4 - - - - - - - 8:134783694-134785879 30 32 29 11 19 18 0.970756244004506 0.941076700151063 0.846079658612911 0.318919176381134 0.504453958513829 0.545875777813234 0.919304200922827 0.456416304236066 1.01019200435034 0.00535493522289955 0.0247701016647727 UP ENSG00000173557 C2orf70 chromosome 2 open reading frame 70 [Source:HGNC Symbol;Acc:HGNC:27938] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005634 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|nucleus - - - - 2:26562582-26579532 2 0 0 2 6 10 0.0426619800652383 0 0 0.0382272934902501 0.105007539643943 0.19991796457406 0.0142206600217461 0.114384265902751 -3.00782828498 0.00535613571324175 0.0247718165117148 DOWN ENSG00000146233 CYP39A1 cytochrome P450 family 39 subfamily A member 1 [Source:HGNC Symbol;Acc:HGNC:17449] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:1901360|GO:0006082|GO:0009410|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0004497|GO:0006629|GO:0005783|GO:0007586|GO:0006805|GO:0044249|GO:0055114|GO:0046872|GO:0020037|GO:0016042|GO:0006066|GO:0016709|GO:0008395|GO:0008387|GO:0071466|GO:0008202|GO:0008396|GO:0008610|GO:0008206|GO:0006699|GO:0033782|GO:0046164|GO:0046395|GO:0030573|GO:0006694|GO:0006706|GO:0016125|GO:0046914|GO:0019752|GO:0005506|GO:0008203|GO:0032787|GO:0006707 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|organic cyclic compound metabolic process|organic acid metabolic process|response to xenobiotic stimulus|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|monooxygenase activity|lipid metabolic process|endoplasmic reticulum|digestion|xenobiotic metabolic process|cellular biosynthetic process|oxidation-reduction process|metal ion binding|heme binding|lipid catabolic process|alcohol metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|steroid hydroxylase activity|steroid 7-alpha-hydroxylase activity|cellular response to xenobiotic stimulus|steroid metabolic process|oxysterol 7-alpha-hydroxylase activity|lipid biosynthetic process|bile acid metabolic process|bile acid biosynthetic process|24-hydroxycholesterol 7alpha-hydroxylase activity|alcohol catabolic process|carboxylic acid catabolic process|bile acid catabolic process|steroid biosynthetic process|steroid catabolic process|sterol metabolic process|transition metal ion binding|carboxylic acid metabolic process|iron ion binding|cholesterol metabolic process|monocarboxylic acid metabolic process|cholesterol catabolic process K07439 24-hydroxycholesterol 7alpha-hydroxylase[1.14.13.99] hsa00120 Primary bile acid biosynthesis - Homo sapiens (human) 6:46549580-46652830 44 38 52 73 77 149 0.719465855667374 0.564705843505465 0.766618575005863 1.06949651982636 1.03304450288496 2.28336693545706 0.683596758059567 1.46196931938946 -1.09669557528587 0.0053738542574257 0.0248422181791866 DOWN ENSG00000259514 RP11-685G9.2 - - - - - - - 15:76339609-76342063 6 6 4 1 1 1 0.559896276634552 0.508870465005827 0.336559641143607 0.083573606201599 0.0766005640954518 0.0874482128993642 0.468442127594662 0.082540794398805 2.50469159658887 0.00541193734277556 0.0249989134196536 UP ENSG00000111886 GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 [Source:HGNC Symbol;Acc:HGNC:4091] GO:0032991|GO:0004871|GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0022857|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0043234|GO:0097060|GO:0006810|GO:0050877|GO:0045211|GO:0005887|GO:0004888|GO:0007267|GO:0043235|GO:0022891|GO:0019904|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0007165|GO:0016021|GO:0007186|GO:0016917|GO:0015267|GO:0006811|GO:0015075|GO:0007600|GO:1902710|GO:0034702|GO:0034220|GO:0015276|GO:0050953|GO:0006820|GO:0005216|GO:0098656|GO:0034707|GO:0008509|GO:0004890|GO:0007214|GO:1902711|GO:0005253|GO:0005230|GO:0007601|GO:0015698|GO:0007268|GO:0005254|GO:1902476|GO:0006821|GO:0015108 macromolecular complex|signal transducer activity|transporter activity|synapse|signaling|cell|membrane|cellular process|cell junction|response to stimulus|binding|cellular response to stimulus|receptor activity|transmembrane transporter activity|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|protein complex|synaptic membrane|transport|neurological system process|postsynaptic membrane|integral component of plasma membrane|transmembrane signaling receptor activity|cell-cell signaling|receptor complex|substrate-specific transmembrane transporter activity|protein domain specific binding|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|GABA receptor activity|channel activity|ion transport|ion transmembrane transporter activity|sensory perception|GABA receptor complex|ion channel complex|ion transmembrane transport|ligand-gated ion channel activity|sensory perception of light stimulus|anion transport|ion channel activity|anion transmembrane transport|chloride channel complex|anion transmembrane transporter activity|GABA-A receptor activity|gamma-aminobutyric acid signaling pathway|GABA-A receptor complex|anion channel activity|extracellular ligand-gated ion channel activity|visual perception|inorganic anion transport|synaptic transmission|chloride channel activity|chloride transmembrane transport|chloride transport|chloride transmembrane transporter activity K05190 gamma-aminobutyric acid receptor subunit rho[-] hsa04080|hsa04723|hsa05032|hsa04727|hsa05033 Neuroactive ligand-receptor interaction - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human)|Nicotine addiction - Homo sapiens (human) 6:89257208-89315299 4 2 1 8 8 15 0.0970282070619548 0.044092799779883 0.0218603147530331 0.173884369291728 0.15923575330179 0.341024421867824 0.0543271071982903 0.224714848153781 -2.04835132075732 0.00542196323172165 0.0250374772343106 DOWN ENSG00000270959 LPP-AS2 LPP antisense RNA 2 [Source:HGNC Symbol;Acc:HGNC:27952] - - - - - - 3:188151206-188154057 14 24 17 34 44 47 0.347242686614028 0.540987114269869 0.380152002022181 0.755569730161408 0.8953989158772 1.09251512386226 0.422793934302026 0.914494589966956 -1.11301995624456 0.00545243993640193 0.0251626436638342 DOWN ENSG00000203972 GLYATL3 glycine-N-acyltransferase like 3 [Source:HGNC Symbol;Acc:HGNC:21349] GO:0005623|GO:0008152|GO:0003824|GO:0043229|GO:0043227|GO:0005622|GO:0016740|GO:0043231|GO:0016746|GO:0005737|GO:0005739|GO:0016747|GO:0016410|GO:0047961 cell|metabolic process|catalytic activity|intracellular organelle|membrane-bounded organelle|intracellular|transferase activity|intracellular membrane-bounded organelle|transferase activity, transferring acyl groups|cytoplasm|mitochondrion|transferase activity, transferring acyl groups other than amino-acyl groups|N-acyltransferase activity|glycine N-acyltransferase activity - - - - 6:49499958-49527047 1 2 7 0 0 0 0.0535300252818562 0.0972576430848252 0.337680022541699 0 0 0 0.162822563636127 0 Inf 0.00546066356766947 0.025188624261259 UP ENSG00000260279 AC137932.5 - - - - - - - 16:89297508-89298317 3 1 2 11 5 13 0.310737656396697 0.0941694388534983 0.186758571000625 1.02072813992556 0.424890036931033 1.26186782344237 0.197221888750273 0.902495333432988 -2.19409979353236 0.00545983424472559 0.025188624261259 DOWN ENSG00000166546 BEAN1 brain expressed, associated with NEDD4, 1 [Source:HGNC Symbol;Acc:HGNC:24160] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 16:66427297-66493529 10 6 5 16 16 37 0.0611247519427628 0.0333325105836862 0.0275541726414361 0.0876278537415581 0.0802458340742401 0.211964625473313 0.040670478389295 0.12661277109637 -1.63836906713862 0.00547311894466443 0.0252346707295771 DOWN ENSG00000253266 RP11-128L5.1 - - - - - - - 8:141055290-141060596 15 14 16 28 31 52 0.65375020005972 0.554542346954389 0.628742348704508 1.09340711939577 1.10856714576635 2.12401839811691 0.612344965239539 1.44199755442634 -1.23565218686912 0.00547421707239354 0.0252358363927172 DOWN ENSG00000106714 CNTNAP3 contactin associated protein-like 3 [Source:HGNC Symbol;Acc:HGNC:13834] GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0007155|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0008037|GO:0016021 cell|membrane|cellular process|extracellular region|binding|cell adhesion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|cell recognition|integral component of membrane - - - - 9:39072767-39288315 21 26 39 48 69 65 0.117366217376536 0.132058928186443 0.196516603752466 0.240353376685152 0.316395596338178 0.340454893225479 0.148647249771815 0.29906795541627 -1.00858056543829 0.00548200728524016 0.0252639465102747 DOWN ENSG00000139187 KLRG1 killer cell lectin-like receptor subfamily G, member 1 [Source:HGNC Symbol;Acc:HGNC:6380] GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0050794|GO:0006950|GO:0006955|GO:0030246|GO:0071944|GO:0031224|GO:0002682|GO:0005515|GO:0005886|GO:0045087|GO:0006952|GO:0050776|GO:0007154|GO:0007165|GO:0016021|GO:0007166|GO:0006954|GO:0006968 immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|receptor activity|regulation of cellular process|response to stress|immune response|carbohydrate binding|cell periphery|intrinsic component of membrane|regulation of immune system process|protein binding|plasma membrane|innate immune response|defense response|regulation of immune response|cell communication|signal transduction|integral component of membrane|cell surface receptor signaling pathway|inflammatory response|cellular defense response - - - - 12:8950044-9010760 0 0 1 4 3 6 0 0 0.0156198671452694 0.0621228645987108 0.0426688462151738 0.0974724305358271 0.00520662238175647 0.0674213804499039 -3.69478648477147 0.00549599018945937 0.0253205696166852 DOWN ENSG00000168874 ATOH8 atonal bHLH transcription factor 8 [Source:HGNC Symbol;Acc:HGNC:24126] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0008283|GO:0050794|GO:0040012|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0048870|GO:0040017|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0051272|GO:0042127|GO:0045595|GO:0035239|GO:0006725|GO:0009888|GO:0035295|GO:1901360|GO:0007275|GO:0010632|GO:0003676|GO:0034641|GO:0051450|GO:0031325|GO:0046483|GO:2000147|GO:0045597|GO:0043231|GO:0005737|GO:0006928|GO:0046983|GO:0048598|GO:0050673|GO:0009890|GO:0006139|GO:0007154|GO:0001704|GO:0035148|GO:0051270|GO:0016477|GO:0007165|GO:0008134|GO:0010634|GO:0008285|GO:0048869|GO:2000145|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0090132|GO:0034645|GO:0007166|GO:0010629|GO:0051252|GO:0009790|GO:0010628|GO:0030334|GO:0001935|GO:0001667|GO:0030856|GO:0007369|GO:0031981|GO:0005654|GO:0030858|GO:0050678|GO:0050680|GO:0060429|GO:0010467|GO:0007399|GO:0060395|GO:0010594|GO:0031328|GO:0009059|GO:0030154|GO:0030335|GO:0016070|GO:0033613|GO:0010557|GO:0005634|GO:0010595|GO:0003158|GO:0000975|GO:0045893|GO:0030855|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0016604|GO:0001936|GO:0007167|GO:0001937|GO:0010631|GO:0045603|GO:0045601|GO:0006351|GO:0006355|GO:0016607|GO:0045446|GO:1903507|GO:1903506|GO:0044212|GO:0007178|GO:0043542|GO:0070888 locomotion|developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|regulation of locomotion|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell motility|positive regulation of locomotion|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of cellular component movement|regulation of cell proliferation|regulation of cell differentiation|tube morphogenesis|cellular aromatic compound metabolic process|tissue development|tube development|organic cyclic compound metabolic process|multicellular organism development|regulation of epithelial cell migration|nucleic acid binding|cellular nitrogen compound metabolic process|myoblast proliferation|positive regulation of cellular metabolic process|heterocycle metabolic process|positive regulation of cell motility|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|movement of cell or subcellular component|protein dimerization activity|embryonic morphogenesis|epithelial cell proliferation|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cell communication|formation of primary germ layer|tube formation|regulation of cellular component movement|cell migration|signal transduction|transcription factor binding|positive regulation of epithelial cell migration|negative regulation of cell proliferation|cellular developmental process|regulation of cell motility|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|epithelium migration|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|negative regulation of gene expression|regulation of RNA metabolic process|embryo development|positive regulation of gene expression|regulation of cell migration|endothelial cell proliferation|ameboidal-type cell migration|regulation of epithelial cell differentiation|gastrulation|nuclear lumen|nucleoplasm|positive regulation of epithelial cell differentiation|regulation of epithelial cell proliferation|negative regulation of epithelial cell proliferation|epithelium development|gene expression|nervous system development|SMAD protein signal transduction|regulation of endothelial cell migration|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of cell migration|RNA metabolic process|activating transcription factor binding|positive regulation of macromolecule biosynthetic process|nucleus|positive regulation of endothelial cell migration|endothelium development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|epithelial cell differentiation|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|nuclear body|regulation of endothelial cell proliferation|enzyme linked receptor protein signaling pathway|negative regulation of endothelial cell proliferation|epithelial cell migration|positive regulation of endothelial cell differentiation|regulation of endothelial cell differentiation|transcription, DNA-templated|regulation of transcription, DNA-templated|nuclear speck|endothelial cell differentiation|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transmembrane receptor protein serine/threonine kinase signaling pathway|endothelial cell migration|E-box binding - - - - 2:85751344-85788066 1 0 2 3 7 9 0.00922041608112233 0 0.0166196878167332 0.0247700975523754 0.0529339712109013 0.0777384006709921 0.00861336796595184 0.0518141564780896 -2.58869694962686 0.00550861432818277 0.0253708997459994 DOWN ENSG00000256576 RP13-977J11.2 - - - - - - - 12:132186735-132189695 31 16 35 12 14 13 1.47765488060409 0.69312455071773 1.50417685020762 0.512513632939364 0.54753130598877 0.580765312271657 1.22498542717648 0.54693675039993 1.1633186768786 0.00552739171084435 0.0254456055721738 UP ENSG00000259185 RP11-56B16.4 - - - - - - - 15:51908902-51909642 0 0 0 5 2 2 0 0 0 0.621318046917943 0.227584968274062 0.259944099520463 0 0.369615704904156 -Inf 0.00553370212530029 0.0254628765796416 DOWN ENSG00000272702 RP11-44N22.3 - - - - - - - 2:73113018-73115907 17 13 14 3 10 4 0.380058059605959 0.264148341240763 0.282203769896962 0.0600854926404809 0.183438618978442 0.083799930945282 0.308803390247895 0.109108014188068 1.50093151734614 0.00553491024125419 0.0254645107631996 UP ENSG00000204380 AC005042.4 - - - - - - - 2:158658337-158735002 0 1 0 2 4 8 0 0.0105283559890226 0 0.0207499926687951 0.0379991271303885 0.0868155966233666 0.00350945199634087 0.0485215721408501 -3.7893086205048 0.00553690108711317 0.0254697450007206 DOWN ENSG00000112182 BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:14078] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0003824|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0016740|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0000981|GO:0009890|GO:0006139|GO:0019787|GO:0000151|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0043412|GO:0010629|GO:0004842|GO:0031461|GO:0051252|GO:0036211|GO:0003705|GO:1990234|GO:0044267|GO:0010467|GO:0001227|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0001206|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0006464|GO:0006351|GO:0031463|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0000122|GO:0032446|GO:0035326|GO:0000976|GO:0001012|GO:0000977|GO:0001158|GO:0016567|GO:0000980 macromolecular complex|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|catalytic activity|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|protein complex|transferase activity|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|ubiquitin-like protein transferase activity|ubiquitin ligase complex|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|macromolecule modification|negative regulation of gene expression|ubiquitin-protein transferase activity|cullin-RING ubiquitin ligase complex|regulation of RNA metabolic process|protein modification process|transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding|transferase complex|cellular protein metabolic process|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|cellular protein modification process|transcription, DNA-templated|Cul3-RING ubiquitin ligase complex|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|negative regulation of transcription from RNA polymerase II promoter|protein modification by small protein conjugation|enhancer binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding|protein ubiquitination|RNA polymerase II distal enhancer sequence-specific DNA binding - - - - 6:89926529-90296908 0 2 5 8 12 8 0 0.0108145852601681 0.0268194874090923 0.0426483994326417 0.0585808835282667 0.0446090066256326 0.0125446908897535 0.0486127631955137 -1.95425821847309 0.0055390098436019 0.0254755199308105 DOWN ENSG00000261533 RP11-15N24.4 - - - - - - - 3:100179567-100181732 1 0 0 2 4 8 0.0326716036115484 0 0 0.0585234096092657 0.107172976749558 0.244855253819089 0.0108905345371828 0.136850546725971 -3.65145452604711 0.00555152636334084 0.025521291661715 DOWN ENSG00000263846 CIAPIN1P cytokine induced apoptosis inhibitor 1 pseudogene [Source:HGNC Symbol;Acc:HGNC:31087] - - - - - - 18:26599408-26600338 22 34 25 9 21 9 1.67154097294149 2.34776398570179 1.71258638640276 0.612669832820075 1.30913500228894 0.640861681149156 1.91063044834868 0.854222172086057 1.161365511109 0.00555856838000211 0.0255457974779223 UP ENSG00000163879 DNALI1 dynein, axonemal, light intermediate chain 1 [Source:HGNC Symbol;Acc:HGNC:14353] GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:0042995|GO:0043229|GO:0044702|GO:0019953|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0005929|GO:0005930|GO:0016817|GO:0005737|GO:0045502|GO:0006928|GO:0005875|GO:0009566|GO:0005858|GO:0045504|GO:0016818|GO:0007338|GO:0030286|GO:0030175|GO:0005856|GO:0015630|GO:0016462|GO:0017111|GO:0003774|GO:0003777 macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|binding|catalytic activity|cell projection|intracellular organelle|single organism reproductive process|sexual reproduction|hydrolase activity|intracellular|protein binding|protein complex|cilium|axoneme|hydrolase activity, acting on acid anhydrides|cytoplasm|dynein binding|movement of cell or subcellular component|microtubule associated complex|fertilization|axonemal dynein complex|dynein heavy chain binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|single fertilization|dynein complex|filopodium|cytoskeleton|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|motor activity|microtubule motor activity K10410 dynein light intermediate chain, axonemal[-] hsa05016 Huntington,s disease - Homo sapiens (human) 1:37556919-37566857 6 6 6 2 1 1 0.0562717286779356 0.0511434384081698 0.0507383070777355 0.0168074390365512 0.00769865123101995 0.00878888164647548 0.0527178247212803 0.0110983239713489 2.24794901966072 0.00560895416134823 0.02576149500506 UP ENSG00000273189 CTD-3148I10.15 - - - - - - - 19:49474586-49487637 7 13 0 0 1 1 0.34846451169008 0.588152956851353 0 0 0.0408608216638652 0.0466472522010683 0.312205822847144 0.0291693579549778 3.41997190817043 0.00561543392621717 0.0257833227365868 UP ENSG00000244009 B3GAT3P1 beta-1,3-glucuronyltransferase 3 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:35243] - - - - - - 3:160452598-160453403 20 12 12 8 6 3 1.7552574688737 0.957131048323615 0.949549161241392 0.629090348454935 0.432016130842822 0.246721136641631 1.2206458928129 0.435942538646463 1.48543484599051 0.00565756453594812 0.0259528167879833 UP ENSG00000151023 ENKUR enkurin, TRPC channel interacting protein [Source:HGNC Symbol;Acc:HGNC:28388] GO:0005623|GO:0005488|GO:0042995|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0005929|GO:0036126|GO:0031982|GO:0030141|GO:0043231|GO:0031514|GO:0005737|GO:0019904|GO:0097228|GO:0005516|GO:0001669|GO:0031410|GO:0017124|GO:0016023|GO:0031988 cell|binding|cell projection|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|cilium|sperm flagellum|vesicle|secretory granule|intracellular membrane-bounded organelle|motile cilium|cytoplasm|protein domain specific binding|sperm principal piece|calmodulin binding|acrosomal vesicle|cytoplasmic vesicle|SH3 domain binding|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle - - - - 10:24981979-25062279 2 7 8 13 20 19 0.0175300032089628 0.0557672291463886 0.0632248346931485 0.102096533430338 0.143834133772819 0.156080569476759 0.0455073556828333 0.134003745559972 -1.55810166374497 0.00569098422215707 0.0260900864509025 DOWN ENSG00000227725 GCOM2 GRINL1B complex locus 2, pseudogene [Source:HGNC Symbol;Acc:HGNC:15712] - - - - - - 4:68038544-68039647 17 16 16 7 10 4 1.0892243664794 0.931700030131442 0.924319594155268 0.401842309005272 0.525724447869376 0.240165744122167 0.981747996922037 0.389244166998938 1.33467732931396 0.00569659158664571 0.0261037674946617 UP ENSG00000163071 SPATA18 spermatogenesis associated 18 [Source:HGNC Symbol;Acc:HGNC:29579] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0043229|GO:0006950|GO:0071704|GO:0009056|GO:0044237|GO:0006914|GO:0016043|GO:0043227|GO:0019867|GO:0005622|GO:0005515|GO:0031090|GO:0033554|GO:0043231|GO:0005737|GO:0031966|GO:0000422|GO:0019538|GO:0006996|GO:0005740|GO:1903008|GO:0030163|GO:0007005|GO:0005741|GO:0044265|GO:0035695|GO:0005739|GO:0044267|GO:0006974|GO:0044257|GO:0035694 cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|intracellular organelle|response to stress|organic substance metabolic process|catabolic process|cellular metabolic process|autophagy|cellular component organization|membrane-bounded organelle|outer membrane|intracellular|protein binding|organelle membrane|cellular response to stress|intracellular membrane-bounded organelle|cytoplasm|mitochondrial membrane|mitophagy|protein metabolic process|organelle organization|mitochondrial envelope|organelle disassembly|protein catabolic process|mitochondrion organization|mitochondrial outer membrane|cellular macromolecule catabolic process|mitophagy by induced vacuole formation|mitochondrion|cellular protein metabolic process|cellular response to DNA damage stimulus|cellular protein catabolic process|mitochondrial protein catabolic process - - - - 4:52051331-52097292 0 0 1 3 3 6 0 0 0.00696206616643124 0.0207634882824903 0.0190183007212892 0.0434452805828648 0.00232068872214375 0.0277423565288814 -3.57946541055059 0.00570279497790158 0.026124173894472 DOWN ENSG00000274031 RP11-413H22.3 - - - - - - - 16:56465642-56466162 5 2 4 0 1 0 0.678888570470776 0.246784269017541 0.489658748535229 0 0.111445734326972 0 0.471777196007849 0.0371485781089907 3.66672678898925 0.00572090908437955 0.0261991133310427 UP ENSG00000261599 HERC2P8 hect domain and RLD 2 pseudogene 8 [Source:HGNC Symbol;Acc:HGNC:38747] - - - - - - 16:33094204-33129090 0 0 0 4 1 4 0 0 0 0.0335171087291564 0.00767625959602756 0.0350532762441661 0 0.0254155481897834 -Inf 0.00574357026423703 0.0262787044702732 DOWN ENSG00000262001 DLGAP1-AS2 DLGAP1 antisense RNA 2 [Source:HGNC Symbol;Acc:HGNC:28146] - - - - - - 18:3603000-3608336 40 38 68 74 93 152 0.775411082440229 0.669475878050052 1.18848288272651 1.28529867264502 1.47918753395107 2.76149701258437 0.87778994773893 1.84199440639349 -1.06932102641407 0.00574744732941919 0.0262924138174196 DOWN ENSG00000262801 U91319.1 - - - - - - - 16:13246316-13562918 1 0 0 3 3 6 0.0685723773474941 0 0 0.184215599529536 0.168732133143531 0.385450570752626 0.0228574591158314 0.246132767808564 -3.42869979296713 0.00577090447032597 0.0263916332808075 DOWN ENSG00000276600 RAB7B RAB7B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:30513] GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0002683|GO:0097159|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0043227|GO:0023057|GO:0009893|GO:0016787|GO:0009058|GO:0002684|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0012505|GO:0048856|GO:0031090|GO:0019222|GO:0002757|GO:1903706|GO:0045087|GO:0045595|GO:0006725|GO:0006810|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0043168|GO:0006952|GO:0001882|GO:0031982|GO:0031325|GO:0046483|GO:0016817|GO:0001817|GO:0034122|GO:0045597|GO:0043231|GO:0005737|GO:0002218|GO:0001816|GO:0012506|GO:0030666|GO:0009966|GO:0045184|GO:0001819|GO:0010646|GO:0006139|GO:0050776|GO:0008104|GO:0007154|GO:0007165|GO:0050778|GO:0009968|GO:0051649|GO:0000166|GO:0048869|GO:0044249|GO:0031323|GO:0005794|GO:0005768|GO:0051090|GO:0016192|GO:0010468|GO:0034645|GO:0005802|GO:0035639|GO:0032675|GO:0030097|GO:0002758|GO:0031410|GO:0032635|GO:0051252|GO:0001883|GO:0015031|GO:0005773|GO:0010628|GO:0032755|GO:0016023|GO:0016818|GO:0034164|GO:0046907|GO:0032549|GO:0051091|GO:0005770|GO:0031988|GO:0002764|GO:0034613|GO:0034144|GO:0035556|GO:0030659|GO:0010467|GO:0045639|GO:0017076|GO:1901534|GO:0031328|GO:0009059|GO:0030154|GO:0034121|GO:0016070|GO:0010557|GO:0030670|GO:0045089|GO:0045637|GO:0045088|GO:1901532|GO:0045654|GO:0032561|GO:0045893|GO:0030139|GO:0051169|GO:0000323|GO:0032774|GO:0042147|GO:2001141|GO:0051092|GO:0048193|GO:0002221|GO:0016482|GO:0006886|GO:0016197|GO:0002244|GO:0005525|GO:0030099|GO:0007264|GO:0045652|GO:0019001|GO:0016462|GO:0006351|GO:0006355|GO:0006913|GO:0002224|GO:0005764|GO:1903506|GO:0034499|GO:0030219|GO:0017111|GO:0045335|GO:0003924|GO:0034142|GO:0034162 developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|negative regulation of immune system process|organic cyclic compound binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|regulation of signaling|membrane-bounded organelle|negative regulation of signaling|positive regulation of metabolic process|hydrolase activity|biosynthetic process|positive regulation of immune system process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|endomembrane system|anatomical structure development|organelle membrane|regulation of metabolic process|immune response-activating signal transduction|regulation of hemopoiesis|innate immune response|regulation of cell differentiation|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|anion binding|defense response|nucleoside binding|vesicle|positive regulation of cellular metabolic process|heterocycle metabolic process|hydrolase activity, acting on acid anhydrides|regulation of cytokine production|negative regulation of toll-like receptor signaling pathway|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|activation of innate immune response|cytokine production|vesicle membrane|endocytic vesicle membrane|regulation of signal transduction|establishment of protein localization|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|regulation of immune response|protein localization|cell communication|signal transduction|positive regulation of immune response|negative regulation of signal transduction|establishment of localization in cell|nucleotide binding|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|Golgi apparatus|endosome|regulation of sequence-specific DNA binding transcription factor activity|vesicle-mediated transport|regulation of gene expression|cellular macromolecule biosynthetic process|trans-Golgi network|purine ribonucleoside triphosphate binding|regulation of interleukin-6 production|hemopoiesis|innate immune response-activating signal transduction|cytoplasmic vesicle|interleukin-6 production|regulation of RNA metabolic process|purine nucleoside binding|protein transport|vacuole|positive regulation of gene expression|positive regulation of interleukin-6 production|cytoplasmic, membrane-bounded vesicle|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|negative regulation of toll-like receptor 9 signaling pathway|intracellular transport|ribonucleoside binding|positive regulation of sequence-specific DNA binding transcription factor activity|late endosome|membrane-bounded vesicle|immune response-regulating signaling pathway|cellular protein localization|negative regulation of toll-like receptor 4 signaling pathway|intracellular signal transduction|cytoplasmic vesicle membrane|gene expression|positive regulation of myeloid cell differentiation|purine nucleotide binding|positive regulation of hematopoietic progenitor cell differentiation|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|regulation of toll-like receptor signaling pathway|RNA metabolic process|positive regulation of macromolecule biosynthetic process|phagocytic vesicle membrane|positive regulation of innate immune response|regulation of myeloid cell differentiation|regulation of innate immune response|regulation of hematopoietic progenitor cell differentiation|positive regulation of megakaryocyte differentiation|guanyl ribonucleotide binding|positive regulation of transcription, DNA-templated|endocytic vesicle|nuclear transport|lytic vacuole|RNA biosynthetic process|retrograde transport, endosome to Golgi|regulation of RNA biosynthetic process|positive regulation of NF-kappaB transcription factor activity|Golgi vesicle transport|pattern recognition receptor signaling pathway|cytosolic transport|intracellular protein transport|endosomal transport|hematopoietic progenitor cell differentiation|GTP binding|myeloid cell differentiation|small GTPase mediated signal transduction|regulation of megakaryocyte differentiation|guanyl nucleotide binding|pyrophosphatase activity|transcription, DNA-templated|regulation of transcription, DNA-templated|nucleocytoplasmic transport|toll-like receptor signaling pathway|lysosome|regulation of nucleic acid-templated transcription|late endosome to Golgi transport|megakaryocyte differentiation|nucleoside-triphosphatase activity|phagocytic vesicle|GTPase activity|toll-like receptor 4 signaling pathway|toll-like receptor 9 signaling pathway K07898 Ras-related protein Rab-7B[-] hsa04145|hsa05146|hsa05132 Phagosome - Homo sapiens (human)|Amoebiasis - Homo sapiens (human)|Salmonella infection - Homo sapiens (human) 1:205976740-206003461 1 0 3 6 4 13 0.00761259610828462 0 0.0205788276477271 0.0409084676894372 0.0249716725085567 0.0927125347903549 0.00939714125200391 0.0528642249961163 -2.49199789246925 0.00577829510363663 0.0264213849018177 DOWN ENSG00000224596 ZMIZ1-AS1 ZMIZ1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:27433] - - - - - - 10:78943328-79067895 4 8 15 20 18 42 0.0587854252633826 0.10685610152349 0.198761148093462 0.263360260528703 0.217052384318903 0.578506937381294 0.121467558293445 0.3529731940763 -1.53898757624699 0.00578407543679439 0.0264407793058474 DOWN ENSG00000275793 RIMBP3 RIMS binding protein 3 [Source:HGNC Symbol;Acc:HGNC:29344] GO:0005488|GO:0005515 binding|protein binding - - - - 22:18605815-18611919 34 30 16 13 10 14 0.39395145980924 0.315908118324666 0.167149685822673 0.134958071217499 0.095069580744929 0.152029724617339 0.29233642131886 0.127352458859922 1.19880276665243 0.00580297218542198 0.0265179751451994 UP ENSG00000184838 PRR16 proline rich 16 [Source:HGNC Symbol;Acc:HGNC:29654] GO:0009987|GO:0008152|GO:0005488|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0009893|GO:0009058|GO:0005515|GO:0019222|GO:0032535|GO:0034641|GO:0031325|GO:0044249|GO:0019538|GO:0031323|GO:0032268|GO:0010468|GO:0034645|GO:0006518|GO:0010628|GO:0008361|GO:0051247|GO:0032270|GO:0043603|GO:0044267|GO:0010467|GO:0031328|GO:0051246|GO:0009059|GO:0010557|GO:0045793|GO:0043043|GO:0045727|GO:0010608|GO:0006412|GO:0006417 cellular process|metabolic process|binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|positive regulation of metabolic process|biosynthetic process|protein binding|regulation of metabolic process|regulation of cellular component size|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|cellular biosynthetic process|protein metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|peptide metabolic process|positive regulation of gene expression|regulation of cell size|positive regulation of protein metabolic process|positive regulation of cellular protein metabolic process|cellular amide metabolic process|cellular protein metabolic process|gene expression|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of macromolecule biosynthetic process|positive regulation of cell size|peptide biosynthetic process|positive regulation of translation|posttranscriptional regulation of gene expression|translation|regulation of translation - - - - 5:120464278-120687332 0 0 0 1 5 3 0 0 0 0.0124726901950801 0.0571372111092529 0.0391528324735488 0 0.0362542445926273 -Inf 0.00582955187861825 0.0266190642068322 DOWN ENSG00000272273 XXbac-BPG252P9.10 - - - - - - - 6:30742929-30743592 5 5 6 0 3 0 0.671159288833537 0.609994184161703 0.726125829184594 0 0.330420420121678 0 0.669093100726611 0.110140140040559 2.60286662017861 0.00583415874612052 0.0266360261823952 UP ENSG00000163661 PTX3 pentraxin 3 [Source:HGNC Symbol;Acc:HGNC:9692] GO:0040011|GO:0002376|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0040013|GO:0009892|GO:0046790|GO:0048523|GO:0050794|GO:0040012|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0016043|GO:0051707|GO:0030246|GO:0009607|GO:0009605|GO:0009893|GO:0009058|GO:0005615|GO:0005515|GO:0019222|GO:0016032|GO:1903409|GO:0045087|GO:0006810|GO:0051130|GO:0051702|GO:0060627|GO:0034641|GO:0006952|GO:2001057|GO:0031325|GO:0051128|GO:0045807|GO:0046597|GO:0009620|GO:0072593|GO:0046596|GO:0001846|GO:0044092|GO:0030247|GO:0048525|GO:0050790|GO:0043086|GO:0044249|GO:0001848|GO:0008228|GO:0019538|GO:0050792|GO:0031324|GO:0031323|GO:0051701|GO:0016192|GO:0006909|GO:0044793|GO:0001878|GO:0001872|GO:0009100|GO:2000377|GO:0006954|GO:0046209|GO:1903428|GO:0030100|GO:0051346|GO:0045428|GO:0050766|GO:1903019|GO:0019058|GO:0031328|GO:0006809|GO:0051246|GO:1903426|GO:2000379|GO:0001849|GO:0050764|GO:1903016|GO:0046718|GO:0044871|GO:0045429|GO:0006897|GO:0030260|GO:0052405|GO:0044869 locomotion|immune system process|cellular process|extracellular region|metabolic process|response to stimulus|binding|negative regulation of locomotion|negative regulation of metabolic process|virion binding|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|immune response|cellular metabolic process|cellular component organization|response to other organism|carbohydrate binding|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|biosynthetic process|extracellular space|protein binding|regulation of metabolic process|viral process|reactive oxygen species biosynthetic process|innate immune response|transport|positive regulation of cellular component organization|interaction with symbiont|regulation of vesicle-mediated transport|cellular nitrogen compound metabolic process|defense response|reactive nitrogen species metabolic process|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of endocytosis|negative regulation of viral entry into host cell|response to fungus|reactive oxygen species metabolic process|regulation of viral entry into host cell|opsonin binding|negative regulation of molecular function|polysaccharide binding|negative regulation of viral process|regulation of catalytic activity|negative regulation of catalytic activity|cellular biosynthetic process|complement binding|opsonization|protein metabolic process|regulation of viral process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|interaction with host|vesicle-mediated transport|phagocytosis|negative regulation by host of viral process|response to yeast|(1->3)-beta-D-glucan binding|glycoprotein metabolic process|regulation of reactive oxygen species metabolic process|inflammatory response|nitric oxide metabolic process|positive regulation of reactive oxygen species biosynthetic process|regulation of endocytosis|negative regulation of hydrolase activity|regulation of nitric oxide biosynthetic process|positive regulation of phagocytosis|negative regulation of glycoprotein metabolic process|viral life cycle|positive regulation of cellular biosynthetic process|nitric oxide biosynthetic process|regulation of protein metabolic process|regulation of reactive oxygen species biosynthetic process|positive regulation of reactive oxygen species metabolic process|complement component C1q binding|regulation of phagocytosis|negative regulation of exo-alpha-sialidase activity|viral entry into host cell|negative regulation by host of viral glycoprotein metabolic process|positive regulation of nitric oxide biosynthetic process|endocytosis|entry into host cell|negative regulation by host of symbiont molecular function|negative regulation by host of viral exo-alpha-sialidase activity - - - - 3:157436789-157443628 11 21 39 82 71 31 0.401083671600136 0.695909158926974 1.2821188936572 2.6788853397548 2.12406566838768 1.0593506050056 0.79303724139477 1.95410053771603 -1.30104417305954 0.00583613273938354 0.0266409643427456 DOWN ENSG00000125510 OPRL1 opiate receptor-like 1 [Source:HGNC Symbol;Acc:HGNC:8155] GO:0004871|GO:0000003|GO:0007610|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0042752|GO:0051716|GO:0042995|GO:0007631|GO:0033218|GO:0004872|GO:0009892|GO:0048523|GO:0007622|GO:0050794|GO:0043229|GO:0006807|GO:0051050|GO:0007623|GO:0044702|GO:0071704|GO:0042698|GO:0051051|GO:0044237|GO:0050795|GO:0038023|GO:0043227|GO:0044708|GO:0071944|GO:0009893|GO:0032504|GO:0009058|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0007626|GO:0048609|GO:0019222|GO:0003014|GO:0042277|GO:0006725|GO:0008022|GO:1904059|GO:0006810|GO:1901360|GO:0050877|GO:0045475|GO:0034641|GO:0044281|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0044849|GO:0005887|GO:0043231|GO:0004888|GO:0005737|GO:0007267|GO:0042592|GO:0001696|GO:0043005|GO:0009890|GO:0019725|GO:0006139|GO:0031226|GO:0055086|GO:0007154|GO:0044092|GO:0055085|GO:0007165|GO:0007586|GO:0009725|GO:0008217|GO:0051047|GO:0032410|GO:0016021|GO:0044249|GO:0042755|GO:0048512|GO:0019538|GO:0010033|GO:0060456|GO:0031324|GO:0031323|GO:0050878|GO:0003013|GO:0034763|GO:0043271|GO:0032268|GO:0005829|GO:0007186|GO:0044058|GO:0033993|GO:1904058|GO:0043412|GO:0031410|GO:0019693|GO:0042923|GO:0048878|GO:0060453|GO:0060454|GO:0016023|GO:0051926|GO:0036211|GO:0006811|GO:0055082|GO:0032413|GO:0007600|GO:0051046|GO:0045776|GO:0031644|GO:0034766|GO:0051247|GO:0031988|GO:0034765|GO:0043269|GO:0032270|GO:0014070|GO:0006796|GO:1901137|GO:0044267|GO:0051174|GO:0046903|GO:0051246|GO:0008528|GO:0008015|GO:0004930|GO:0048545|GO:0097305|GO:0022898|GO:0034220|GO:0098655|GO:0031401|GO:0007187|GO:0019233|GO:0009259|GO:0035810|GO:2001258|GO:0009117|GO:0038003|GO:0046390|GO:0006812|GO:0045980|GO:0016310|GO:0043627|GO:1903170|GO:0032412|GO:1901020|GO:0004985|GO:0006163|GO:0032355|GO:0050801|GO:0007218|GO:0006464|GO:0009165|GO:0046717|GO:0006873|GO:1903169|GO:0006164|GO:0007188|GO:0051930|GO:0006468|GO:0042325|GO:0001932|GO:0001626|GO:1901019|GO:0009187|GO:0030001|GO:0001934|GO:0051924|GO:2001257|GO:1901386|GO:0030003|GO:0042327|GO:0030802|GO:0007268|GO:0009190|GO:0007193|GO:0030818|GO:1901385|GO:0070588|GO:0046058|GO:0055065|GO:0009152|GO:0030817|GO:0052652|GO:0006875|GO:0030814|GO:0030815|GO:0006171|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0007204 signal transducer activity|reproduction|behavior|signaling|cell|rhythmic process|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|regulation of circadian rhythm|cellular response to stimulus|cell projection|feeding behavior|amide binding|receptor activity|negative regulation of metabolic process|negative regulation of cellular process|rhythmic behavior|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|positive regulation of transport|circadian rhythm|single organism reproductive process|organic substance metabolic process|ovulation cycle|negative regulation of transport|cellular metabolic process|regulation of behavior|signaling receptor activity|membrane-bounded organelle|single-organism behavior|cell periphery|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|intracellular|protein binding|plasma membrane|locomotory behavior|multicellular organismal reproductive process|regulation of metabolic process|renal system process|peptide binding|cellular aromatic compound metabolic process|protein C-terminus binding|regulation of locomotor rhythm|transport|organic cyclic compound metabolic process|neurological system process|locomotor rhythm|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|estrous cycle|integral component of plasma membrane|intracellular membrane-bounded organelle|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|homeostatic process|gastric acid secretion|neuron projection|negative regulation of biosynthetic process|cellular homeostasis|nucleobase-containing compound metabolic process|intrinsic component of plasma membrane|nucleobase-containing small molecule metabolic process|cell communication|negative regulation of molecular function|transmembrane transport|signal transduction|digestion|response to hormone|regulation of blood pressure|positive regulation of secretion|negative regulation of transporter activity|integral component of membrane|cellular biosynthetic process|eating behavior|circadian behavior|protein metabolic process|response to organic substance|positive regulation of digestive system process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of body fluid levels|circulatory system process|negative regulation of transmembrane transport|negative regulation of ion transport|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|regulation of digestive system process|response to lipid|positive regulation of sensory perception of pain|macromolecule modification|cytoplasmic vesicle|ribose phosphate metabolic process|neuropeptide binding|chemical homeostasis|regulation of gastric acid secretion|positive regulation of gastric acid secretion|cytoplasmic, membrane-bounded vesicle|negative regulation of calcium ion transport|protein modification process|ion transport|cellular chemical homeostasis|negative regulation of ion transmembrane transporter activity|sensory perception|regulation of secretion|negative regulation of blood pressure|regulation of neurological system process|negative regulation of ion transmembrane transport|positive regulation of protein metabolic process|membrane-bounded vesicle|regulation of ion transmembrane transport|regulation of ion transport|positive regulation of cellular protein metabolic process|response to organic cyclic compound|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|regulation of phosphorus metabolic process|secretion|regulation of protein metabolic process|G-protein coupled peptide receptor activity|blood circulation|G-protein coupled receptor activity|response to steroid hormone|response to alcohol|regulation of transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|positive regulation of protein modification process|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|sensory perception of pain|ribonucleotide metabolic process|positive regulation of urine volume|negative regulation of cation channel activity|nucleotide metabolic process|opioid receptor signaling pathway|ribose phosphate biosynthetic process|cation transport|negative regulation of nucleotide metabolic process|phosphorylation|response to estrogen|negative regulation of calcium ion transmembrane transport|regulation of ion transmembrane transporter activity|negative regulation of calcium ion transmembrane transporter activity|opioid receptor activity|purine nucleotide metabolic process|response to estradiol|ion homeostasis|neuropeptide signaling pathway|cellular protein modification process|nucleotide biosynthetic process|acid secretion|cellular ion homeostasis|regulation of calcium ion transmembrane transport|purine nucleotide biosynthetic process|adenylate cyclase-modulating G-protein coupled receptor signaling pathway|regulation of sensory perception of pain|protein phosphorylation|regulation of phosphorylation|regulation of protein phosphorylation|nociceptin receptor activity|regulation of calcium ion transmembrane transporter activity|cyclic nucleotide metabolic process|metal ion transport|positive regulation of protein phosphorylation|regulation of calcium ion transport|regulation of cation channel activity|negative regulation of voltage-gated calcium channel activity|cellular cation homeostasis|positive regulation of phosphorylation|regulation of cyclic nucleotide biosynthetic process|synaptic transmission|cyclic nucleotide biosynthetic process|adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway|negative regulation of cAMP biosynthetic process|regulation of voltage-gated calcium channel activity|calcium ion transmembrane transport|cAMP metabolic process|metal ion homeostasis|purine ribonucleotide biosynthetic process|regulation of cAMP biosynthetic process|cyclic purine nucleotide metabolic process|cellular metal ion homeostasis|regulation of cAMP metabolic process|negative regulation of cAMP metabolic process|cAMP biosynthetic process|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04216 nociceptin receptor[-] hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) 20:64080173-64100643 4 5 11 15 15 33 0.0763449141372532 0.0867422922431779 0.189294440849158 0.256524751752968 0.234916267045787 0.5903161533908 0.11746054907653 0.360585724063185 -1.61816599328183 0.00584247865708428 0.0266591100612706 DOWN ENSG00000227885 RP11-79N23.1 - - - - - - - 6:53740749-53747022 2 1 1 7 7 6 0.166431912819212 0.075667913808164 0.0749937386115817 0.5219222460492 0.477962622404315 0.467982340019659 0.105697855079653 0.489289069491058 -2.21074095344744 0.00586034040859409 0.0267310317124779 DOWN ENSG00000231527 RP11-374M1.2 - - - - - - - 9:61972240-61976380 1 1 1 8 6 4 0.0210302209279685 0.0191137375146922 0.0189434406596863 0.150682561918181 0.103478455114209 0.0787943481458759 0.0196957997007823 0.110985121726089 -2.49440638649847 0.00586315908025188 0.0267397278390972 DOWN ENSG00000111644 ACRBP acrosin binding protein [Source:HGNC Symbol;Acc:HGNC:17195] GO:0005623|GO:0005576|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0012505|GO:0031982|GO:0030141|GO:0043231|GO:0005737|GO:0001669|GO:0031410|GO:0016023|GO:0031988|GO:0005634 cell|extracellular region|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|endomembrane system|vesicle|secretory granule|intracellular membrane-bounded organelle|cytoplasm|acrosomal vesicle|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|nucleus - - - - 12:6638075-6647460 31 17 36 2 9 20 0.398770656995174 0.198747874159311 0.417520117026359 0.0230517739977577 0.0949875546214655 0.24110855447448 0.338346216060281 0.119715961031234 1.49888474284186 0.00588062512685831 0.0268094325123352 UP ENSG00000273049 RP11-834C11.12 - GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 12:53985845-54034888 5 5 0 0 0 0 0.45521357170563 0.41372835914185 0 0 0 0 0.289647310282493 0 Inf 0.00588555799066956 0.0268255646188472 UP ENSG00000279443 RP4-669K10.8 - - - - - - - 1:28544460-28546542 31 54 20 11 23 14 1.05273156160176 1.66659352485346 0.612367277932919 0.334689063643379 0.640841584709925 0.445579197690282 1.11056412146271 0.473703282014529 1.22923712057974 0.00591182856998253 0.0269370772479027 UP ENSG00000243224 RP5-1157M23.2 - - - - - - - 3:52239258-52241097 8 12 9 3 5 2 0.262340520901864 0.357648412122779 0.266096010103641 0.0881365316247016 0.134538662598005 0.0614610527378007 0.295361647709428 0.0947120823201691 1.64086212073458 0.00598229539625022 0.0272456821906413 UP ENSG00000236830 CBR3-AS1 CBR3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:43664] - - - - - - 21:36131767-36175815 10 11 10 22 25 31 0.0472659959560074 0.0472563145691703 0.0426181436663639 0.0931717099323968 0.0969556535095586 0.137329781069888 0.0457134847305139 0.109152381503948 -1.25565190299745 0.006026575609649 0.027430612631569 DOWN ENSG00000261033 RP11-209D14.2 - - - - - - - 17:20008051-20009234 7 9 9 1 2 5 0.418216276276693 0.488696067035047 0.484771194082392 0.053504048564875 0.0980306873477801 0.279982469289689 0.463894512464711 0.143839068400781 1.68934119812863 0.00604260447851511 0.0274951858103323 UP ENSG00000189350 FAM179A family with sequence similarity 179 member A [Source:HGNC Symbol;Acc:HGNC:33715] GO:0005488 binding - - - - 2:28956611-29061373 17 7 6 3 2 4 0.0562022668065645 0.0210339100397904 0.0178850398196056 0.00888532897338201 0.0054247678921187 0.0123921752435442 0.0317070722219868 0.00890075736968164 1.83280466152233 0.00605396109089563 0.0275300768328406 UP ENSG00000162913 C1orf145 chromosome 1 open reading frame 145 [Source:HGNC Symbol;Acc:HGNC:32047] - - - - - - 1:228203506-228213664 28 23 44 59 49 124 0.449524744325356 0.335596543912044 0.636896854176499 0.848700437241303 0.645455652134742 1.86574901908604 0.4740060474713 1.11996836948736 -1.24048061722568 0.0060582926676318 0.0275455786322692 DOWN ENSG00000271609 CTB-31N19.4 - - - - - - - 16:21538487-21538794 0 0 3 6 4 9 0 0 0.621106434458674 1.23469193389938 0.753690479349166 1.9371500816554 0.207035478152891 1.30851083163465 -2.65997594872423 0.0060717746277095 0.0275858447405099 DOWN ENSG00000189366 ALG1L ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like [Source:HGNC Symbol;Acc:HGNC:33721] GO:0005623|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0012505|GO:0016740|GO:0006486|GO:0043231|GO:0005737|GO:0005975|GO:0005783|GO:0016757|GO:0044249|GO:0019538|GO:0034645|GO:0043412|GO:0009100|GO:0036211|GO:0016758|GO:0070085|GO:1901137|GO:0044267|GO:0009059|GO:0097502|GO:0009101|GO:0043413|GO:0000030|GO:0006464 cell|cellular process|metabolic process|catalytic activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|endomembrane system|transferase activity|protein glycosylation|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|endoplasmic reticulum|transferase activity, transferring glycosyl groups|cellular biosynthetic process|protein metabolic process|cellular macromolecule biosynthetic process|macromolecule modification|glycoprotein metabolic process|protein modification process|transferase activity, transferring hexosyl groups|glycosylation|carbohydrate derivative biosynthetic process|cellular protein metabolic process|macromolecule biosynthetic process|mannosylation|glycoprotein biosynthetic process|macromolecule glycosylation|mannosyltransferase activity|cellular protein modification process - - - - 3:125929275-125937039 0 1 2 5 5 8 0 0.0762962357496315 0.15131210438129 0.375886362904094 0.344246613551478 0.629129869243353 0.0758694467103072 0.449754281899642 -2.56754609496895 0.00608306356908495 0.02762454818854 DOWN ENSG00000279356 RP11-429P3.8 - - - - - - - 16:50072862-50074986 11 10 12 7 1 4 0.366165799013771 0.302528480372092 0.360158411275559 0.20876889841968 0.0273238718044012 0.124773167769822 0.342950896887141 0.120288645997968 1.51150155514356 0.00609753657497121 0.0276734352248694 UP ENSG00000232732 AC073043.1 - - - - - - - 2:199867396-199911159 0 1 3 4 14 5 0 0.00343320843049746 0.0102114221102419 0.0135327965425077 0.0433722887844206 0.0176950594448058 0.00454821018024645 0.0248667149239114 -2.4508450993226 0.00610120550108033 0.0276858776454252 DOWN ENSG00000234805 AC090505.5 - - - - - - - 3:194755589-194757422 24 29 36 22 11 11 0.925666178683129 1.01655517172894 1.25187738469354 0.760258799966367 0.34809427300066 0.397608351093403 1.06469957836854 0.501987141353477 1.08472409448958 0.00610791318396775 0.0277078924470708 UP ENSG00000161912 ADCY10P1 adenylate cyclase 10 (soluble) pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:44143] - - - - - - 6:41101022-41140835 16 17 17 29 34 59 0.142994727494572 0.138081435249785 0.136979596938378 0.232218909222007 0.24930864404725 0.494169626599896 0.139351919894245 0.325232393289718 -1.22273807859951 0.00612435658649034 0.027752966231494 DOWN ENSG00000258676 RP11-386M24.3 - - - - - - - 15:92580829-92600545 52 38 55 70 85 208 1.53648456815007 1.02043336633444 1.46520164464855 1.85318773853565 2.06066159346676 5.7598988961259 1.34070652637769 3.22458274270944 -1.26611901610979 0.00612397386466843 0.027752966231494 DOWN ENSG00000237415 NRBF2P3 nuclear receptor binding factor 2 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:44606] - - - - - - 1:110848077-110848941 30 22 23 14 9 14 2.45326375652468 1.63505276964107 1.69579401358097 1.02581726762507 0.603857298108022 1.07299591767498 1.92803684658224 0.900890161136024 1.09770949832507 0.00612577471381257 0.0277551795881257 UP ENSG00000277715 RP11-651L5.3 - - - - - - - 12:106250759-106252786 1 2 0 13 3 5 0.0348948192419201 0.0633997061923762 0 0.406271708472795 0.085863689055288 0.163461165502462 0.0327648418114321 0.218532187676848 -2.73762531886771 0.00613455882107737 0.0277781160388964 DOWN ENSG00000268379 CTC-360J11.4 - - - - - - - 19:57175233-57177921 4 5 4 0 1 1 0.136551279822712 0.155148134678194 0.123123652503308 0 0.0280227932356913 0.031991189854111 0.138274355668071 0.0200046610299341 2.78912553120907 0.00614079770351092 0.0278021496270268 UP ENSG00000234494 SP2-AS1 SP2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51341] - - - - - - 17:47897330-47941410 28 25 24 61 66 41 0.505256638647326 0.410003310365971 0.390460841726374 0.986242784052756 0.977180005815594 0.693384730673074 0.43524026357989 0.885602506847141 -1.02484728108367 0.00614706772652471 0.0278263168927473 DOWN ENSG00000204581 AC096670.3 - - - - - - - 2:111098345-111115588 4 3 3 8 9 24 0.0813263155483358 0.055444763120172 0.0549872899721965 0.145744990185305 0.150139857103604 0.457335280056464 0.0639194562135681 0.251073375781791 -1.97378201116343 0.00616019982964802 0.0278646372294412 DOWN ENSG00000134259 NGF nerve growth factor (beta polypeptide) [Source:HGNC Symbol;Acc:HGNC:7808] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0042445|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0009893|GO:0030234|GO:0050793|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0019222|GO:0051726|GO:0007049|GO:0004857|GO:0045595|GO:0048468|GO:0051130|GO:0010941|GO:0007275|GO:0005102|GO:0034641|GO:0031982|GO:0031325|GO:0051128|GO:0010942|GO:0045786|GO:0045597|GO:0043231|GO:0005737|GO:0007267|GO:0016486|GO:0009966|GO:0060548|GO:0010646|GO:0043085|GO:0007154|GO:0044092|GO:0007165|GO:0008219|GO:0050790|GO:0030030|GO:0043086|GO:0010817|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0005794|GO:0005768|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0031344|GO:0010468|GO:0005126|GO:1901215|GO:0006518|GO:0007166|GO:0043412|GO:0031410|GO:0051345|GO:0010720|GO:0030414|GO:0043069|GO:0070997|GO:0051604|GO:0031346|GO:0000904|GO:0010628|GO:0016023|GO:0051347|GO:0036211|GO:0032269|GO:0005796|GO:0050769|GO:0051247|GO:0051346|GO:0070848|GO:0006508|GO:0031988|GO:0022604|GO:1901214|GO:0032270|GO:0012501|GO:0006796|GO:0043603|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0007399|GO:0071310|GO:0051246|GO:0010770|GO:0030154|GO:0048858|GO:0043068|GO:0032455|GO:1902531|GO:0008083|GO:0043067|GO:0051960|GO:0097190|GO:0048666|GO:0030182|GO:0008191|GO:0004866|GO:0010466|GO:0010975|GO:0031401|GO:0043065|GO:0043408|GO:0010769|GO:0016485|GO:0032813|GO:0043523|GO:0030162|GO:0071363|GO:0016310|GO:0038179|GO:0052547|GO:0061564|GO:0048017|GO:0007167|GO:0043410|GO:0042981|GO:0045861|GO:0043066|GO:0051402|GO:0043524|GO:0050772|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050767|GO:0048812|GO:0097191|GO:0010976|GO:0060193|GO:0043549|GO:0006915|GO:0033674|GO:0045666|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:0048015|GO:0045860|GO:0007409|GO:0010517|GO:0043281|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0010951|GO:0001934|GO:0010518|GO:0005163|GO:0050770|GO:0045664|GO:0042327|GO:0008625|GO:0007169|GO:0052548|GO:0005123|GO:0010863|GO:0071900|GO:2000116|GO:0032147|GO:0007202 developmental process|signaling|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|hormone metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|regulation of developmental process|intracellular|protein binding|endomembrane system|anatomical structure development|regulation of metabolic process|regulation of cell cycle|cell cycle|enzyme inhibitor activity|regulation of cell differentiation|cell development|positive regulation of cellular component organization|regulation of cell death|multicellular organism development|receptor binding|cellular nitrogen compound metabolic process|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|positive regulation of cell death|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cytoplasm|cell-cell signaling|peptide hormone processing|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|positive regulation of catalytic activity|cell communication|negative regulation of molecular function|signal transduction|cell death|regulation of catalytic activity|cell projection organization|negative regulation of catalytic activity|regulation of hormone levels|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|Golgi apparatus|endosome|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|regulation of cell projection organization|regulation of gene expression|cytokine receptor binding|negative regulation of neuron death|peptide metabolic process|cell surface receptor signaling pathway|macromolecule modification|cytoplasmic vesicle|positive regulation of hydrolase activity|positive regulation of cell development|peptidase inhibitor activity|negative regulation of programmed cell death|neuron death|protein maturation|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|positive regulation of gene expression|cytoplasmic, membrane-bounded vesicle|positive regulation of transferase activity|protein modification process|negative regulation of cellular protein metabolic process|Golgi lumen|positive regulation of neurogenesis|positive regulation of protein metabolic process|negative regulation of hydrolase activity|response to growth factor|proteolysis|membrane-bounded vesicle|regulation of cell morphogenesis|regulation of neuron death|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|cellular amide metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|nervous system development|cellular response to organic substance|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|cell differentiation|cell projection morphogenesis|positive regulation of programmed cell death|nerve growth factor processing|regulation of intracellular signal transduction|growth factor activity|regulation of programmed cell death|regulation of nervous system development|apoptotic signaling pathway|neuron development|neuron differentiation|metalloendopeptidase inhibitor activity|endopeptidase inhibitor activity|negative regulation of peptidase activity|regulation of neuron projection development|positive regulation of protein modification process|positive regulation of apoptotic process|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|protein processing|tumor necrosis factor receptor superfamily binding|regulation of neuron apoptotic process|regulation of proteolysis|cellular response to growth factor stimulus|phosphorylation|neurotrophin signaling pathway|regulation of peptidase activity|axon development|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|positive regulation of MAPK cascade|regulation of apoptotic process|negative regulation of proteolysis|negative regulation of apoptotic process|neuron apoptotic process|negative regulation of neuron apoptotic process|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|positive regulation of neuron projection development|positive regulation of lipase activity|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|positive regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|axonogenesis|regulation of phospholipase activity|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|negative regulation of endopeptidase activity|positive regulation of protein phosphorylation|positive regulation of phospholipase activity|nerve growth factor receptor binding|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|extrinsic apoptotic signaling pathway via death domain receptors|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|death receptor binding|positive regulation of phospholipase C activity|regulation of protein serine/threonine kinase activity|regulation of cysteine-type endopeptidase activity|activation of protein kinase activity|activation of phospholipase C activity K02582 nerve growth factor, beta[-] hsa04151|hsa04010|hsa04014|hsa04015|hsa04210|hsa04722|hsa04750 PI3K-Akt signaling pathway - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Apoptosis - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human)|Inflammatory mediator regulation of TRP channels - Homo sapiens (human) 1:115285918-115338236 15 6 24 28 50 39 1.01340647057968 0.368408607902977 1.46189732527926 1.69493768364788 2.77161672353495 2.4694332889045 0.947904134587306 2.31199589869578 -1.28632577263216 0.00625620676325554 0.0282432778935779 DOWN ENSG00000074410 CA12 carbonic anhydrase XII [Source:HGNC Symbol;Acc:HGNC:1371] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016829|GO:0043167|GO:0044237|GO:0071944|GO:0031224|GO:0005886|GO:0006810|GO:0044281|GO:0043169|GO:0042592|GO:0006730|GO:0016021|GO:0046872|GO:0048878|GO:0006811|GO:0016836|GO:0006820|GO:0015711|GO:0004089|GO:0046914|GO:0050801|GO:0055081|GO:0015701|GO:0008270|GO:0055064 cell|membrane|cellular process|metabolic process|binding|catalytic activity|lyase activity|ion binding|cellular metabolic process|cell periphery|intrinsic component of membrane|plasma membrane|transport|small molecule metabolic process|cation binding|homeostatic process|one-carbon metabolic process|integral component of membrane|metal ion binding|chemical homeostasis|ion transport|hydro-lyase activity|anion transport|organic anion transport|carbonate dehydratase activity|transition metal ion binding|ion homeostasis|anion homeostasis|bicarbonate transport|zinc ion binding|chloride ion homeostasis K01672 carbonic anhydrase[4.2.1.1] hsa00910 Nitrogen metabolism - Homo sapiens (human) 15:63321378-63382161 26 27 58 68 73 96 0.157527956967982 0.148675595785246 0.316835997212475 0.369145159815047 0.36289626139964 0.545114110536647 0.207679849988568 0.425718510583778 -1.03553857466424 0.00626074796658405 0.0282595055631086 DOWN ENSG00000183307 CECR6 cat eye syndrome chromosome region, candidate 6 [Source:HGNC Symbol;Acc:HGNC:1844] - - - - - - 22:17116299-17121367 12 4 11 4 3 1 0.0952180612817587 0.0288445550551069 0.0786904316081862 0.028437847496056 0.0195324241619881 0.00743530514612654 0.0675843493150173 0.0184685256013902 1.87162050032953 0.00626275374106303 0.0282642857423576 UP ENSG00000279693 RP11-71L14.3 - - - - - - - 16:68367325-68370262 7 8 4 0 1 3 0.168539166477741 0.175050516212579 0.0868319291990654 0 0.0197628412472268 0.0676845596096509 0.143473870629795 0.0291491336189592 2.29926310924429 0.0063254229334818 0.0285255553257048 UP ENSG00000100365 NCF4 neutrophil cytosolic factor 4 [Source:HGNC Symbol;Acc:HGNC:7662] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0019882|GO:0043229|GO:0043167|GO:0006955|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009893|GO:0031224|GO:0030234|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031090|GO:0019222|GO:0019884|GO:0098797|GO:0043168|GO:0008047|GO:0005543|GO:0031982|GO:0005887|GO:0043231|GO:0005737|GO:0046983|GO:0043020|GO:0031226|GO:0043085|GO:0007154|GO:0007165|GO:0010008|GO:0050790|GO:0048002|GO:0016021|GO:0005768|GO:0006996|GO:0055114|GO:0005829|GO:0007166|GO:0031410|GO:0035091|GO:0005773|GO:0016023|GO:0090382|GO:0031988|GO:0002474|GO:0016176|GO:0035556|GO:0042590|GO:0030139|GO:0000323|GO:0007167|GO:1901981|GO:0007264|GO:0005764|GO:0045335|GO:0002479|GO:0032266|GO:0007169|GO:0048010|GO:0032010|GO:0005767 macromolecular complex|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|antigen processing and presentation|intracellular organelle|ion binding|immune response|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|positive regulation of metabolic process|intrinsic component of membrane|enzyme regulator activity|intracellular|protein binding|plasma membrane|protein complex|endomembrane system|organelle membrane|regulation of metabolic process|antigen processing and presentation of exogenous antigen|plasma membrane protein complex|anion binding|enzyme activator activity|phospholipid binding|vesicle|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|NADPH oxidase complex|intrinsic component of plasma membrane|positive regulation of catalytic activity|cell communication|signal transduction|endosome membrane|regulation of catalytic activity|antigen processing and presentation of peptide antigen|integral component of membrane|endosome|organelle organization|oxidation-reduction process|cytosol|cell surface receptor signaling pathway|cytoplasmic vesicle|phosphatidylinositol binding|vacuole|cytoplasmic, membrane-bounded vesicle|phagosome maturation|membrane-bounded vesicle|antigen processing and presentation of peptide antigen via MHC class I|superoxide-generating NADPH oxidase activator activity|intracellular signal transduction|antigen processing and presentation of exogenous peptide antigen via MHC class I|endocytic vesicle|lytic vacuole|enzyme linked receptor protein signaling pathway|phosphatidylinositol phosphate binding|small GTPase mediated signal transduction|lysosome|phagocytic vesicle|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|phosphatidylinositol-3-phosphate binding|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|phagolysosome|secondary lysosome K08012 neutrophil cytosolic factor 4[-] hsa04145|hsa04380|hsa04670|hsa05140 Phagosome - Homo sapiens (human)|Osteoclast differentiation - Homo sapiens (human)|Leukocyte transendothelial migration - Homo sapiens (human)|Leishmaniasis - Homo sapiens (human) 22:36860988-36878015 13 14 12 30 35 28 0.404562010031058 0.395962265335228 0.336707709617493 0.836498662557411 0.893682861952634 0.816635468907748 0.379077328327926 0.848938997805931 -1.16316871470464 0.00633034047681692 0.0285434201170355 DOWN ENSG00000182557 SPNS3 spinster homolog 3 (Drosophila) [Source:HGNC Symbol;Acc:HGNC:28433] GO:0040011|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0050794|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0031090|GO:0006810|GO:0031982|GO:0043231|GO:0005774|GO:0005737|GO:0005319|GO:0007154|GO:0055085|GO:0007165|GO:0016021|GO:0010876|GO:0007186|GO:0005773|GO:0006869|GO:0046624|GO:0000323|GO:0003376|GO:0005765|GO:0005764 locomotion|transporter activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|regulation of cellular process|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|organelle membrane|transport|vesicle|intracellular membrane-bounded organelle|vacuolar membrane|cytoplasm|lipid transporter activity|cell communication|transmembrane transport|signal transduction|integral component of membrane|lipid localization|G-protein coupled receptor signaling pathway|vacuole|lipid transport|sphingolipid transporter activity|lytic vacuole|sphingosine-1-phosphate signaling pathway|lysosomal membrane|lysosome - - - - 17:4433688-4488208 8 9 12 19 25 31 0.159534396274407 0.163128317837467 0.215770122345803 0.339499334768491 0.40906156040895 0.579402360786825 0.179477612152559 0.442654418654755 -1.30237692778172 0.00635770263036779 0.0286322127817827 DOWN ENSG00000257270 RP11-521B24.5 - - - - - - - 14:105467793-105470617 20 32 44 14 15 20 3.17918543800494 4.62290711579826 6.30599447079024 1.9940043516757 1.95640378802626 2.97945155293296 4.70269567486448 2.30995323087831 1.02562433221442 0.00638259270774828 0.0287183003311405 UP ENSG00000197506 SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 [Source:HGNC Symbol;Acc:HGNC:16484] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0022857|GO:0043229|GO:0042175|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005789|GO:0005886|GO:0012505|GO:0031090|GO:0006810|GO:0005887|GO:0043231|GO:0005737|GO:0042592|GO:0022891|GO:0048871|GO:0031226|GO:0055085|GO:0005783|GO:0005337|GO:0016021|GO:1901642|GO:0001894|GO:0015205|GO:0015075|GO:0015211|GO:0015851|GO:0005415|GO:1901264|GO:0015932|GO:0072531|GO:0015855|GO:0015858|GO:0015860|GO:1904823|GO:0015293|GO:0015389|GO:0006863|GO:0001895|GO:0005345|GO:0015390|GO:0005350|GO:0008324|GO:0022890|GO:0015864|GO:0015077|GO:0046873|GO:0015081 transporter activity|cell|membrane|cellular process|transmembrane transporter activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|plasma membrane|endomembrane system|organelle membrane|transport|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|homeostatic process|substrate-specific transmembrane transporter activity|multicellular organismal homeostasis|intrinsic component of plasma membrane|transmembrane transport|endoplasmic reticulum|nucleoside transmembrane transporter activity|integral component of membrane|nucleoside transmembrane transport|tissue homeostasis|nucleobase transmembrane transporter activity|ion transmembrane transporter activity|purine nucleoside transmembrane transporter activity|nucleobase transport|nucleoside:sodium symporter activity|carbohydrate derivative transport|nucleobase-containing compound transmembrane transporter activity|pyrimidine-containing compound transmembrane transport|pyrimidine nucleobase transport|nucleoside transport|purine nucleoside transmembrane transport|purine nucleobase transmembrane transport|symporter activity|pyrimidine- and adenine-specific:sodium symporter activity|purine nucleobase transport|retina homeostasis|purine nucleobase transmembrane transporter activity|purine-specific nucleoside:sodium symporter activity|pyrimidine nucleobase transmembrane transporter activity|cation transmembrane transporter activity|inorganic cation transmembrane transporter activity|pyrimidine nucleoside transport|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|sodium ion transmembrane transporter activity - - - - 9:84275457-84340683 1 1 3 6 5 13 0.0135594354134152 0.0123237644638704 0.0366546813208031 0.072865513631157 0.0556045018631722 0.165138096074179 0.0208459603993629 0.0978693705228361 -2.23108958007981 0.00639017643467531 0.0287437588188635 DOWN ENSG00000268230 CTD-2619J13.8 - - - - - - - 19:58346854-58362751 14 9 22 28 36 43 0.214776868840427 0.125486042804054 0.304283321529811 0.384862232656544 0.453122153861149 0.618225902189088 0.214848744391431 0.485403429568927 -1.17586295593283 0.00640929210941604 0.0288167178666425 DOWN ENSG00000280217 RP11-638F5.2 - - - - - - - 12:131235511-131237523 8 7 4 0 3 1 0.281107055929121 0.22356758033351 0.126732343758994 0 0.0865035079007074 0.0329288352596712 0.210468993340542 0.0398107810534595 2.4023766273327 0.0064214220431787 0.0288625615292167 UP ENSG00000232901 CYCSP10 cytochrome c, somatic pseudogene 10 [Source:HGNC Symbol;Acc:HGNC:24384] - - - - - - 3:10000647-10000940 1 2 4 14 7 7 0.240703038852428 0.437328585571901 0.867728598594742 3.0181358384207 1.38186472463832 1.57847188569533 0.515253407673024 1.99282414958478 -1.95146036347073 0.00643954446155494 0.0289353040871856 DOWN ENSG00000260456 C16orf95 chromosome 16 open reading frame 95 [Source:HGNC Symbol;Acc:HGNC:40033] - - - - - - 16:87083562-87317420 31 18 31 56 81 44 0.415074738371468 0.219036804357988 0.374235517266941 0.671815163649187 0.889851824175636 0.552134276049897 0.336115686665466 0.704600421291573 -1.06784746202002 0.00643873399087012 0.0289353040871856 DOWN ENSG00000259828 RP11-63E9.1 - - - - - - - 6:141447011-141451006 5 7 6 1 3 0 0.0885137500538724 0.11262300781065 0.0957628408359062 0.0158530514266296 0.0435764668178489 0 0.0989665329001429 0.0198098394148262 2.32072355218952 0.00649560396879721 0.029169639122213 UP ENSG00000273466 RP11-548H3.1 - - - - - - - 2:218633256-218634014 50 30 19 10 8 23 4.65982960382879 2.54100008217666 1.59650805502067 0.835057346598613 0.611767400036917 2.00893767317355 2.93244591367537 1.15192080660303 1.34806296293177 0.00653870561756138 0.0293411269362209 UP ENSG00000239884 RN7SL608P RNA, 7SL, cytoplasmic 608, pseudogene [Source:HGNC Symbol;Acc:HGNC:46624] - - - - - - 17:2680958-2681236 16 21 31 5 15 11 4.05664253806286 4.8389382377001 7.08633060115143 1.13574266640914 3.1204289809021 2.61366923263549 5.3273037923048 2.28994695998224 1.21809137085061 0.00655821479932839 0.0294065702341769 UP ENSG00000240005 RP11-293A21.1 - - - - - - - 4:26859806-26860599 12 5 2 1 2 0 0.963528962913596 0.36488868905019 0.144785589095831 0.0719055544844631 0.131746122383396 0 0.491067747019872 0.0678838922892864 2.8547808776416 0.00658283245805076 0.0294948041726921 UP ENSG00000011028 MRC2 mannose receptor, C type 2 [Source:HGNC Symbol;Acc:HGNC:16875] GO:0032502|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0005488|GO:0030055|GO:0044877|GO:0071704|GO:0009056|GO:0030246|GO:0031224|GO:0005515|GO:0006810|GO:0005924|GO:0005912|GO:0032403|GO:0044236|GO:0001503|GO:0048869|GO:0016021|GO:0016192|GO:0030574|GO:0044259|GO:0005518|GO:0001649|GO:0030154|GO:0005925|GO:0006897|GO:0032963 developmental process|membrane|cellular process|metabolic process|cell junction|binding|cell-substrate junction|macromolecular complex binding|organic substance metabolic process|catabolic process|carbohydrate binding|intrinsic component of membrane|protein binding|transport|cell-substrate adherens junction|adherens junction|protein complex binding|multicellular organism metabolic process|ossification|cellular developmental process|integral component of membrane|vesicle-mediated transport|collagen catabolic process|multicellular organismal macromolecule metabolic process|collagen binding|osteoblast differentiation|cell differentiation|focal adhesion|endocytosis|collagen metabolic process K06560 mannose receptor, C type[-] hsa05152|hsa04145 Tuberculosis - Homo sapiens (human)|Phagosome - Homo sapiens (human) 17:62627401-62693597 3 3 15 11 19 51 0.0187369841369245 0.0170294279946216 0.0844563790742327 0.0615482757631464 0.097354670549239 0.298489989826612 0.0400742637352596 0.152464312046332 -1.92772366477315 0.00660151762651146 0.0295607780443788 DOWN ENSG00000152503 TRIM36 tripartite motif containing 36 [Source:HGNC Symbol;Acc:HGNC:16280] GO:0000003|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0050794|GO:0043229|GO:0044702|GO:0071704|GO:0043167|GO:0019953|GO:0044237|GO:0043227|GO:0016874|GO:0005622|GO:0005515|GO:0007340|GO:0012505|GO:0016740|GO:0051726|GO:0007049|GO:0031982|GO:0030141|GO:0043231|GO:0043169|GO:0005737|GO:0001669|GO:0070062|GO:0009566|GO:0019787|GO:0019538|GO:0046872|GO:0043412|GO:0031410|GO:0004842|GO:0016023|GO:0036211|GO:0007338|GO:0031988|GO:0044267|GO:0005856|GO:0046914|GO:0006464|GO:0008270|GO:0032446|GO:0016567 reproduction|cell|cellular process|extracellular region|reproductive process|metabolic process|binding|catalytic activity|extracellular vesicle|regulation of cellular process|intracellular organelle|single organism reproductive process|organic substance metabolic process|ion binding|sexual reproduction|cellular metabolic process|membrane-bounded organelle|ligase activity|intracellular|protein binding|acrosome reaction|endomembrane system|transferase activity|regulation of cell cycle|cell cycle|vesicle|secretory granule|intracellular membrane-bounded organelle|cation binding|cytoplasm|acrosomal vesicle|extracellular exosome|fertilization|ubiquitin-like protein transferase activity|protein metabolic process|metal ion binding|macromolecule modification|cytoplasmic vesicle|ubiquitin-protein transferase activity|cytoplasmic, membrane-bounded vesicle|protein modification process|single fertilization|membrane-bounded vesicle|cellular protein metabolic process|cytoskeleton|transition metal ion binding|cellular protein modification process|zinc ion binding|protein modification by small protein conjugation|protein ubiquitination - - - - 5:115124762-115180546 6 10 13 2 3 5 0.0415753700714136 0.0629773727263612 0.0812187795631276 0.0124178786455397 0.0170583426140404 0.032474455685638 0.0619238407869675 0.020650225648406 1.58433741020635 0.00660094933841696 0.0295607780443788 UP ENSG00000174514 MFSD4 major facilitator superfamily domain containing 4 [Source:HGNC Symbol;Acc:HGNC:25433] GO:0016020|GO:0009987|GO:0031224|GO:0006810|GO:0055085|GO:0016021 membrane|cellular process|intrinsic component of membrane|transport|transmembrane transport|integral component of membrane - - - - 1:205568885-205602918 29 23 75 78 75 171 0.218254358646679 0.157318690549683 0.508910924270976 0.525961713873494 0.463121841223595 1.20611477759313 0.294827991155779 0.731732777563406 -1.31144338371164 0.00661263029902842 0.0296060985223747 DOWN ENSG00000262061 RP11-1260E13.4 - - - - - - - 17:331205-333488 4 2 3 8 15 11 0.053687713812649 0.0243974580945235 0.0362999585983437 0.0962138179989901 0.165199181341876 0.138370724080702 0.0381283768351721 0.133261241140523 -1.80532021500183 0.00661918567504079 0.0296310045198182 DOWN ENSG00000235146 RP5-857K21.2 - - - - - - - 1:587629-594768 1 0 1 2 8 6 0.0701354741552169 0 0.0631760929829975 0.125631025979851 0.460189748888028 0.394236857301001 0.0444371890460715 0.326685877389627 -2.87806462403725 0.00665183080545027 0.0297606258107525 DOWN ENSG00000232104 RFX3-AS1 RFX3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51197] - - - - - - 9:3526723-3691814 2 1 2 5 5 15 0.0662299278540871 0.0301112952888293 0.0597172771504808 0.148348410078722 0.135861374168491 0.465555811875737 0.0520195000977991 0.249921865374317 -2.26435268635835 0.00665712248678728 0.0297740426547637 DOWN ENSG00000081985 IL12RB2 interleukin 12 receptor subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:5972] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0004872|GO:0008283|GO:0050794|GO:0071704|GO:0009986|GO:0044237|GO:0038023|GO:0051707|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0005515|GO:0005886|GO:0008284|GO:0042127|GO:0009897|GO:0001817|GO:0005887|GO:0019899|GO:0004888|GO:0001816|GO:0001819|GO:0031226|GO:0009617|GO:0007154|GO:0007165|GO:0016021|GO:0019538|GO:0010033|GO:0007166|GO:0033993|GO:0043412|GO:0004896|GO:0034097|GO:0002237|GO:0036211|GO:0019900|GO:0006796|GO:0044267|GO:0032609|GO:0071310|GO:0032729|GO:0032496|GO:0032649|GO:0019221|GO:0016310|GO:0071345|GO:0019901|GO:0006464|GO:0006468|GO:0018193|GO:0018108 signal transducer activity|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|receptor activity|cell proliferation|regulation of cellular process|organic substance metabolic process|cell surface|cellular metabolic process|signaling receptor activity|response to other organism|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|protein binding|plasma membrane|positive regulation of cell proliferation|regulation of cell proliferation|external side of plasma membrane|regulation of cytokine production|integral component of plasma membrane|enzyme binding|transmembrane signaling receptor activity|cytokine production|positive regulation of cytokine production|intrinsic component of plasma membrane|response to bacterium|cell communication|signal transduction|integral component of membrane|protein metabolic process|response to organic substance|cell surface receptor signaling pathway|response to lipid|macromolecule modification|cytokine receptor activity|response to cytokine|response to molecule of bacterial origin|protein modification process|kinase binding|phosphate-containing compound metabolic process|cellular protein metabolic process|interferon-gamma production|cellular response to organic substance|positive regulation of interferon-gamma production|response to lipopolysaccharide|regulation of interferon-gamma production|cytokine-mediated signaling pathway|phosphorylation|cellular response to cytokine stimulus|protein kinase binding|cellular protein modification process|protein phosphorylation|peptidyl-amino acid modification|peptidyl-tyrosine phosphorylation K05064 interleukin 12 receptor beta-2[-] hsa04060|hsa04630|hsa05321 Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Inflammatory bowel disease (IBD) - Homo sapiens (human) 1:67307364-67396900 10 6 27 3 5 6 0.137801603249883 0.0751458820328106 0.335471270160607 0.0370369177312452 0.056536118298051 0.0774956144587396 0.182806251814434 0.0570228834960119 1.68070251065653 0.00667308192289506 0.0298364816124171 UP ENSG00000257178 RP11-357H14.16 - - - - - - - 17:48579630-48582259 0 0 1 3 9 2 0 0 0.0242375200835911 0.0722853607279397 0.198607058122981 0.0504074109336259 0.00807917336119703 0.107099943261516 -3.72860621762594 0.00667476181410101 0.0298395236894537 DOWN ENSG00000137941 TTLL7 tubulin tyrosine ligase like 7 [Source:HGNC Symbol;Acc:HGNC:26242] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0097159|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0044297|GO:0016874|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0043025|GO:0007275|GO:0043168|GO:0005874|GO:0001882|GO:0005737|GO:0043005|GO:0043204|GO:0036477|GO:0008092|GO:0000166|GO:0048869|GO:0019538|GO:0015631|GO:0035639|GO:0043412|GO:0001883|GO:0016881|GO:0036211|GO:0032549|GO:0030425|GO:0044267|GO:0007399|GO:0017076|GO:0030154|GO:0005856|GO:0048487|GO:0005524|GO:0030554|GO:0043014|GO:0015630|GO:0006464|GO:0070740|GO:0018193|GO:0018095 developmental process|cell|cellular process|metabolic process|binding|catalytic activity|small molecule binding|cell projection|organic cyclic compound binding|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|cell body|ligase activity|intracellular|protein binding|anatomical structure development|cilium|neuronal cell body|multicellular organism development|anion binding|microtubule|nucleoside binding|cytoplasm|neuron projection|perikaryon|somatodendritic compartment|cytoskeletal protein binding|nucleotide binding|cellular developmental process|protein metabolic process|tubulin binding|purine ribonucleoside triphosphate binding|macromolecule modification|purine nucleoside binding|acid-amino acid ligase activity|protein modification process|ribonucleoside binding|dendrite|cellular protein metabolic process|nervous system development|purine nucleotide binding|cell differentiation|cytoskeleton|beta-tubulin binding|ATP binding|adenyl nucleotide binding|alpha-tubulin binding|microtubule cytoskeleton|cellular protein modification process|tubulin-glutamic acid ligase activity|peptidyl-amino acid modification|protein polyglutamylation - - - - 1:83865028-83999150 55 70 228 205 236 418 0.209685869059034 0.242541292741989 0.783712157223685 0.700261831196659 0.738223204285652 1.49352683457238 0.411979773008236 0.97733729001823 -1.24628303122867 0.00667625066637365 0.0298417109438417 DOWN ENSG00000254198 RP11-598P20.3 - - - - - - - 8:43125995-43126397 22 21 30 15 5 14 3.86154998959933 3.35003416456161 4.74758017753764 2.35900925557444 0.720098995592793 2.30308056771429 3.98638811056619 1.79406293962717 1.15185167226861 0.0066935320001845 0.0298921023685128 UP ENSG00000238181 AHCYP2 adenosylhomocysteinase pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:44994] - - - - - - 9:120720673-120721972 4 12 4 1 2 1 0.2176417321482 0.593421249960641 0.196240159989888 0.0487298411544708 0.0892833337075166 0.050989034905937 0.33576771403291 0.0630007365893081 2.41402291218239 0.00675011045724734 0.0301222417923262 UP ENSG00000269578 CTD-3222D19.5 - - - - - - - 19:16586905-16587985 3 6 2 0 0 1 0.1963310076956 0.356821288135446 0.117998246062375 0 0 0.0613189133928937 0.223716847297807 0.0204396377976312 3.45223236836424 0.00677994264842866 0.0302418060400701 UP ENSG00000279368 RP1-80N2.4 - - - - - - - 6:6685148-6686984 14 7 6 28 27 21 0.539105140023521 0.244987228748697 0.208311547076909 0.96603143972745 0.853026504404092 0.757834342097378 0.330801305283042 0.85896409540964 -1.376632901016 0.00678615452121556 0.0302604715573367 DOWN ENSG00000006042 TMEM98 transmembrane protein 98 [Source:HGNC Symbol;Acc:HGNC:24529] GO:0005623|GO:0016020|GO:0043229|GO:0043227|GO:0031224|GO:0005622|GO:0012505|GO:0043231|GO:0005737|GO:0005783|GO:0016021 cell|membrane|intracellular organelle|membrane-bounded organelle|intrinsic component of membrane|intracellular|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|integral component of membrane - - - - 17:32927910-32945106 3 9 7 3 1 0 0.0268616402124977 0.0732332797581946 0.0565008213897134 0.0240615743215392 0.00734884540999272 0 0.0521985804534686 0.0104701399105106 2.31772985220736 0.0068066736538184 0.0303474365682638 UP ENSG00000247157 LINC01252 long intergenic non-protein coding RNA 1252 [Source:HGNC Symbol;Acc:HGNC:27888] - - - - - - 12:11548030-11590369 2 0 1 8 4 6 0.031119033413183 0 0.0140221464627903 0.11153691615809 0.0510639392079946 0.0875021973199979 0.0150470599586578 0.0833676842286942 -2.47000663422278 0.00680839226228055 0.0303505663129944 DOWN ENSG00000188783 PRELP proline/arginine-rich end leucine-rich repeat protein [Source:HGNC Symbol;Acc:HGNC:9357] GO:0032502|GO:0031012|GO:0005198|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:1903561|GO:0005201|GO:0043229|GO:0005578|GO:0006807|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0012505|GO:0048856|GO:0008201|GO:0006082|GO:0007275|GO:0043168|GO:0044281|GO:0031982|GO:0043231|GO:0005737|GO:0005975|GO:0070062|GO:0048869|GO:0044249|GO:0005539|GO:0005794|GO:0006790|GO:0007568|GO:0005773|GO:0005796|GO:0007569|GO:1901137|GO:0042339|GO:0005775|GO:0009059|GO:0001501|GO:0042340|GO:0000323|GO:0043202|GO:0006024|GO:0030203|GO:0018146|GO:0005764|GO:0006027 developmental process|extracellular matrix|structural molecule activity|cell|cellular process|extracellular region|metabolic process|binding|extracellular vesicle|extracellular matrix structural constituent|intracellular organelle|proteinaceous extracellular matrix|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|extracellular space|intracellular|protein binding|endomembrane system|anatomical structure development|heparin binding|organic acid metabolic process|multicellular organism development|anion binding|small molecule metabolic process|vesicle|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|extracellular exosome|cellular developmental process|cellular biosynthetic process|glycosaminoglycan binding|Golgi apparatus|sulfur compound metabolic process|aging|vacuole|Golgi lumen|cell aging|carbohydrate derivative biosynthetic process|keratan sulfate metabolic process|vacuolar lumen|macromolecule biosynthetic process|skeletal system development|keratan sulfate catabolic process|lytic vacuole|lysosomal lumen|glycosaminoglycan biosynthetic process|glycosaminoglycan metabolic process|keratan sulfate biosynthetic process|lysosome|glycosaminoglycan catabolic process - - - - 1:203475828-203491352 3 4 1 8 11 13 0.0369294970104305 0.0447449466358583 0.0110918179606481 0.0882280878466465 0.111084895890588 0.149966195129831 0.0309220872023123 0.116426392955689 -1.91270853526309 0.0068470943242583 0.0305022659647218 DOWN ENSG00000266501 RP11-766H1.1 - - - - - - - 17:73067870-73068288 34 25 16 14 9 12 5.74003260652842 3.83583049316135 2.4354387397313 2.11773731860546 1.24662664167885 1.89856673337236 4.00376727980702 1.75431023121889 1.19045422381202 0.00687207449498225 0.0306024630031623 UP ENSG00000204335 SP5 Sp5 transcription factor [Source:HGNC Symbol;Acc:HGNC:14529] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0043227|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0006725|GO:1901360|GO:0036342|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0009887|GO:0006139|GO:0060348|GO:0044249|GO:0010033|GO:0031323|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0014070|GO:0010467|GO:0071310|GO:0060349|GO:0009059|GO:0001501|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0071407|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|post-anal tail morphogenesis|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|organ morphogenesis|nucleobase-containing compound metabolic process|bone development|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|response to organic cyclic compound|gene expression|cellular response to organic substance|bone morphogenesis|macromolecule biosynthetic process|skeletal system development|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|cellular response to organic cyclic compound|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 2:170715351-170718078 37 62 41 30 30 13 1.14290009629059 1.74052957593987 1.14183406521164 0.830288847158513 0.760323689953904 0.376356211096567 1.34175457914737 0.655656249402995 1.03310927665221 0.00688608139771262 0.0306465524817103 UP ENSG00000230224 PHBP9 prohibitin pseudogene 9 [Source:HGNC Symbol;Acc:HGNC:39288] - - - - - - 10:100248271-100249095 5 7 7 22 19 13 0.428728418442756 0.545504896013765 0.541106654303182 1.69007835047069 1.33665012522573 1.04467360413471 0.505113322919901 1.35713402661038 -1.4258842041065 0.00690110672275953 0.0306905467155166 DOWN ENSG00000279433 RP11-4B16.1 - - - - - - - 18:77108284-77110537 1 0 1 1 5 14 0.0313960485459689 0 0.0282806911356897 0.0281050547918421 0.128748844376174 0.411775274529218 0.0198922465605529 0.189543057899078 -3.25224749470939 0.00690049889912005 0.0306905467155166 DOWN ENSG00000281909 RP11-439M15.1 - - - - - - - 15:22480439-22484840 1 2 1 5 6 9 0.0932367502274227 0.169400005478444 0.0839850827665935 0.417486434687946 0.45876811786471 0.78608988820799 0.115540612824153 0.554114813586882 -2.26178488443284 0.00690689537310213 0.0307117149938324 DOWN ENSG00000261324 RP11-174G6.5 - - - - - - - 12:14762504-14767931 29 21 5 55 41 74 0.377924229351535 0.248722138599545 0.0587429782252577 0.642197994852218 0.438383593713642 0.903791416489454 0.228463115392113 0.661457668351771 -1.53368756477679 0.00691832044263347 0.0307442004308395 DOWN ENSG00000148516 ZEB1 zinc finger E-box binding homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11642] GO:0032502|GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0000988|GO:0051716|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0044877|GO:0008283|GO:0050794|GO:0045321|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0023051|GO:0000989|GO:0009653|GO:0007155|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005515|GO:0043234|GO:0048856|GO:0019222|GO:0042127|GO:1903706|GO:0016337|GO:0090102|GO:0045595|GO:0035239|GO:0003712|GO:0006725|GO:0009888|GO:0048468|GO:0035295|GO:1901360|GO:0048839|GO:0007275|GO:0003676|GO:0045596|GO:0048513|GO:0070489|GO:0034641|GO:0030155|GO:0031325|GO:0046483|GO:0090287|GO:0098609|GO:0061061|GO:0045597|GO:0043231|GO:0043169|GO:0010243|GO:0005737|GO:0000981|GO:0007389|GO:0007423|GO:0071559|GO:0009887|GO:0005667|GO:0001775|GO:0009966|GO:0048598|GO:0048568|GO:0009890|GO:0003682|GO:0010646|GO:0006139|GO:0046649|GO:0050865|GO:0007154|GO:0007165|GO:0008134|GO:0008285|GO:0048869|GO:0044249|GO:0010033|GO:0031324|GO:0031323|GO:0072089|GO:0003713|GO:0051249|GO:0003677|GO:0048705|GO:0010468|GO:0034645|GO:0051216|GO:0003714|GO:0046872|GO:0007166|GO:0001654|GO:0030097|GO:0030098|GO:0007417|GO:0010629|GO:0043583|GO:0010720|GO:0042692|GO:0051252|GO:0034109|GO:0010463|GO:0090103|GO:0009790|GO:0071417|GO:0010628|GO:0051147|GO:0043200|GO:0071560|GO:0030856|GO:0042472|GO:0022407|GO:0031981|GO:0050769|GO:0007159|GO:0070848|GO:0005654|GO:0048752|GO:0060872|GO:0042110|GO:0060429|GO:0010467|GO:0048562|GO:0007399|GO:0071310|GO:0001227|GO:0031328|GO:0009059|GO:0030154|GO:0001501|GO:0061448|GO:0016070|GO:0010557|GO:0030857|GO:0005634|GO:0051960|GO:0072091|GO:0031076|GO:0030182|GO:0002521|GO:0048706|GO:0000975|GO:0045893|GO:0009792|GO:0050863|GO:0030855|GO:0051145|GO:0045892|GO:0043010|GO:0032774|GO:2001141|GO:0030217|GO:0071363|GO:0045619|GO:1902679|GO:0007179|GO:0048048|GO:0070486|GO:0042471|GO:0007167|GO:0033081|GO:0033077|GO:0046914|GO:0048704|GO:0051150|GO:0022008|GO:0048596|GO:0050767|GO:0071230|GO:0017015|GO:0006351|GO:0006355|GO:0048592|GO:0010464|GO:0045666|GO:0045944|GO:0006366|GO:1903507|GO:0006357|GO:0048593|GO:0048699|GO:0045580|GO:1903506|GO:0044212|GO:0043009|GO:0007178|GO:0000122|GO:0071593|GO:0008270|GO:0045664|GO:0070888 developmental process|macromolecular complex|immune system process|signaling|cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|macromolecular complex binding|cell proliferation|regulation of cellular process|leukocyte activation|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|immune response|cellular metabolic process|regulation of signaling|transcription factor activity, transcription factor binding|anatomical structure morphogenesis|cell adhesion|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|regulation of immune system process|immune system development|protein binding|protein complex|anatomical structure development|regulation of metabolic process|regulation of cell proliferation|regulation of hemopoiesis|single organismal cell-cell adhesion|cochlea development|regulation of cell differentiation|tube morphogenesis|transcription cofactor activity|cellular aromatic compound metabolic process|tissue development|cell development|tube development|organic cyclic compound metabolic process|inner ear development|multicellular organism development|nucleic acid binding|negative regulation of cell differentiation|animal organ development|T cell aggregation|cellular nitrogen compound metabolic process|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular response to growth factor stimulus|cell-cell adhesion|muscle structure development|positive regulation of cell differentiation|intracellular membrane-bounded organelle|cation binding|response to organonitrogen compound|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|pattern specification process|sensory organ development|response to transforming growth factor beta|organ morphogenesis|transcription factor complex|cell activation|regulation of signal transduction|embryonic morphogenesis|embryonic organ development|negative regulation of biosynthetic process|chromatin binding|regulation of cell communication|nucleobase-containing compound metabolic process|lymphocyte activation|regulation of cell activation|cell communication|signal transduction|transcription factor binding|negative regulation of cell proliferation|cellular developmental process|cellular biosynthetic process|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|stem cell proliferation|transcription coactivator activity|regulation of lymphocyte activation|DNA binding|skeletal system morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|cartilage development|transcription corepressor activity|metal ion binding|cell surface receptor signaling pathway|eye development|hemopoiesis|lymphocyte differentiation|central nervous system development|negative regulation of gene expression|ear development|positive regulation of cell development|muscle cell differentiation|regulation of RNA metabolic process|homotypic cell-cell adhesion|mesenchymal cell proliferation|cochlea morphogenesis|embryo development|cellular response to organonitrogen compound|positive regulation of gene expression|regulation of muscle cell differentiation|response to amino acid|cellular response to transforming growth factor beta stimulus|regulation of epithelial cell differentiation|inner ear morphogenesis|regulation of cell-cell adhesion|nuclear lumen|positive regulation of neurogenesis|leukocyte cell-cell adhesion|response to growth factor|nucleoplasm|semicircular canal morphogenesis|semicircular canal development|T cell activation|epithelium development|gene expression|embryonic organ morphogenesis|nervous system development|cellular response to organic substance|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|skeletal system development|connective tissue development|RNA metabolic process|positive regulation of macromolecule biosynthetic process|negative regulation of epithelial cell differentiation|nucleus|regulation of nervous system development|regulation of stem cell proliferation|embryonic camera-type eye development|neuron differentiation|leukocyte differentiation|embryonic skeletal system development|regulatory region DNA binding|positive regulation of transcription, DNA-templated|embryo development ending in birth or egg hatching|regulation of T cell activation|epithelial cell differentiation|smooth muscle cell differentiation|negative regulation of transcription, DNA-templated|camera-type eye development|RNA biosynthetic process|regulation of RNA biosynthetic process|T cell differentiation|cellular response to growth factor stimulus|regulation of lymphocyte differentiation|negative regulation of RNA biosynthetic process|transforming growth factor beta receptor signaling pathway|embryonic eye morphogenesis|leukocyte aggregation|ear morphogenesis|enzyme linked receptor protein signaling pathway|regulation of T cell differentiation in thymus|T cell differentiation in thymus|transition metal ion binding|embryonic skeletal system morphogenesis|regulation of smooth muscle cell differentiation|neurogenesis|embryonic camera-type eye morphogenesis|regulation of neurogenesis|cellular response to amino acid stimulus|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|regulation of mesenchymal cell proliferation|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|camera-type eye morphogenesis|generation of neurons|regulation of T cell differentiation|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|chordate embryonic development|transmembrane receptor protein serine/threonine kinase signaling pathway|negative regulation of transcription from RNA polymerase II promoter|lymphocyte aggregation|zinc ion binding|regulation of neuron differentiation|E-box binding K09299 zinc finger homeobox protein 1/2[-] hsa05206|hsa05202 MicroRNAs in cancer - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human) 10:31318495-31529814 1 0 3 9 3 10 0.00353709668729014 0 0.00956169249828917 0.028509802286974 0.00870353183406428 0.0331348013459081 0.00436626306185977 0.0234493784889821 -2.42507872690116 0.00692775160322801 0.0307769488635073 DOWN ENSG00000115705 TPO thyroid peroxidase [Source:HGNC Symbol;Acc:HGNC:12015] GO:0016209|GO:0032502|GO:0002376|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0016491|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0009986|GO:0044237|GO:0042445|GO:0043227|GO:0071944|GO:0004601|GO:0009058|GO:0031224|GO:0005615|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0006575|GO:0098869|GO:0006725|GO:1901360|GO:0007275|GO:0048513|GO:0034641|GO:0004447|GO:0044281|GO:0042403|GO:0033554|GO:0005887|GO:0043231|GO:0043169|GO:0005737|GO:0072593|GO:0048568|GO:0042744|GO:0006979|GO:0031226|GO:0042446|GO:0010817|GO:0016021|GO:0010035|GO:0010033|GO:0016684|GO:0055114|GO:0009636|GO:0046872|GO:0042743|GO:0020037|GO:0033993|GO:0030097|GO:0006590|GO:0009790|GO:0071731|GO:0034599|GO:0035162|GO:0005739|GO:0018958|GO:0000302|GO:0071241|GO:1902170|GO:0005509|GO:0071732|GO:0034614 antioxidant activity|developmental process|immune system process|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cell surface|cellular metabolic process|hormone metabolic process|membrane-bounded organelle|cell periphery|peroxidase activity|biosynthetic process|intrinsic component of membrane|extracellular space|intracellular|immune system development|protein binding|plasma membrane|anatomical structure development|cellular modified amino acid metabolic process|cellular oxidant detoxification|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|animal organ development|cellular nitrogen compound metabolic process|iodide peroxidase activity|small molecule metabolic process|thyroid hormone metabolic process|cellular response to stress|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|cytoplasm|reactive oxygen species metabolic process|embryonic organ development|hydrogen peroxide catabolic process|response to oxidative stress|intrinsic component of plasma membrane|hormone biosynthetic process|regulation of hormone levels|integral component of membrane|response to inorganic substance|response to organic substance|oxidoreductase activity, acting on peroxide as acceptor|oxidation-reduction process|response to toxic substance|metal ion binding|hydrogen peroxide metabolic process|heme binding|response to lipid|hemopoiesis|thyroid hormone generation|embryo development|response to nitric oxide|cellular response to oxidative stress|embryonic hemopoiesis|mitochondrion|phenol-containing compound metabolic process|response to reactive oxygen species|cellular response to inorganic substance|cellular response to reactive nitrogen species|calcium ion binding|cellular response to nitric oxide|cellular response to reactive oxygen species - - - - 2:1374223-1543711 8 11 12 17 27 37 0.054588896737924 0.0682221442723938 0.0738314319853909 0.103940038125619 0.151168212289245 0.236624989964999 0.0655474909985696 0.163911080126621 -1.32230091791351 0.00701991570073892 0.0311398983488572 DOWN ENSG00000273014 RP11-225B17.2 - - - - - - - 7:32758882-32759353 33 31 43 6 30 15 4.94556561167965 4.22232370573946 5.81007651128829 0.80568880432417 3.6888585804967 2.10683731814952 4.9926552762358 2.2004615676568 1.18200112308525 0.00709916628025776 0.0314542164040984 UP ENSG00000178631 ACTG1P1 actin gamma 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:146] - - - - - - 3:139493809-139494937 3 2 2 15 3 16 0.187983896650969 0.113883617500566 0.112981491579652 0.842055562441539 0.154235218249888 0.939515464609648 0.138283001910396 0.645268748433692 -2.22227632703445 0.00712750320961479 0.0315563518937921 DOWN ENSG00000228716 DHFR dihydrofolate reductase [Source:HGNC Symbol;Acc:HGNC:2861] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0033218|GO:0097159|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0008144|GO:0044237|GO:0072341|GO:0016043|GO:0043227|GO:0048037|GO:0009893|GO:0009058|GO:0005622|GO:0048856|GO:0019222|GO:0019430|GO:0006575|GO:0007049|GO:0005542|GO:0098869|GO:0006725|GO:0048468|GO:0022402|GO:1901360|GO:0006082|GO:0007275|GO:0003676|GO:0034641|GO:0043168|GO:0044281|GO:2001057|GO:0019637|GO:0046483|GO:0033554|GO:0043231|GO:0010243|GO:0005737|GO:0006520|GO:0009611|GO:0072593|GO:0043177|GO:0051870|GO:0051186|GO:0006979|GO:0019842|GO:0006139|GO:0043085|GO:0055086|GO:0050662|GO:0050790|GO:0000166|GO:0030030|GO:0006730|GO:0048869|GO:0010035|GO:0044249|GO:0010033|GO:0031323|GO:0055114|GO:0009636|GO:0005829|GO:0031175|GO:1902882|GO:0010468|GO:0034645|GO:0031427|GO:0003723|GO:1903047|GO:0031102|GO:0048678|GO:0051252|GO:0044770|GO:2000121|GO:2000377|GO:0050661|GO:0000278|GO:0046209|GO:0042558|GO:1900407|GO:0031981|GO:0034599|GO:0008652|GO:0005654|GO:0070402|GO:0051353|GO:0051341|GO:0014070|GO:0000302|GO:0006796|GO:0043603|GO:0031406|GO:0000305|GO:0010467|GO:0007399|GO:0006760|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0006801|GO:0006766|GO:0048666|GO:0030182|GO:0000083|GO:1901031|GO:0042559|GO:0009117|GO:0032770|GO:0032774|GO:0044772|GO:2001141|GO:0046653|GO:0046655|GO:0009108|GO:0061564|GO:0046146|GO:0016597|GO:0019752|GO:0044822|GO:0009396|GO:0046452|GO:0009069|GO:0034614|GO:0022008|GO:0031103|GO:0009165|GO:0006767|GO:0006351|GO:0006355|GO:0004146|GO:0000303|GO:0051000|GO:0006366|GO:0006544|GO:0043648|GO:0071451|GO:0006357|GO:0048699|GO:0003729|GO:1903506|GO:0006729|GO:0000082|GO:0050999|GO:0009070|GO:0046654|GO:0006545 developmental process|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|amide binding|organic cyclic compound binding|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|drug binding|cellular metabolic process|modified amino acid binding|cellular component organization|membrane-bounded organelle|cofactor binding|positive regulation of metabolic process|biosynthetic process|intracellular|anatomical structure development|regulation of metabolic process|removal of superoxide radicals|cellular modified amino acid metabolic process|cell cycle|folic acid binding|cellular oxidant detoxification|cellular aromatic compound metabolic process|cell development|cell cycle process|organic cyclic compound metabolic process|organic acid metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|anion binding|small molecule metabolic process|reactive nitrogen species metabolic process|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|cellular amino acid metabolic process|response to wounding|reactive oxygen species metabolic process|organic acid binding|methotrexate binding|cofactor metabolic process|response to oxidative stress|vitamin binding|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|nucleobase-containing small molecule metabolic process|coenzyme binding|regulation of catalytic activity|nucleotide binding|cell projection organization|one-carbon metabolic process|cellular developmental process|response to inorganic substance|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|oxidation-reduction process|response to toxic substance|cytosol|neuron projection development|regulation of response to oxidative stress|regulation of gene expression|cellular macromolecule biosynthetic process|response to methotrexate|RNA binding|mitotic cell cycle process|neuron projection regeneration|response to axon injury|regulation of RNA metabolic process|cell cycle phase transition|regulation of removal of superoxide radicals|regulation of reactive oxygen species metabolic process|NADP binding|mitotic cell cycle|nitric oxide metabolic process|pteridine-containing compound metabolic process|regulation of cellular response to oxidative stress|nuclear lumen|cellular response to oxidative stress|cellular amino acid biosynthetic process|nucleoplasm|NADPH binding|positive regulation of oxidoreductase activity|regulation of oxidoreductase activity|response to organic cyclic compound|response to reactive oxygen species|phosphate-containing compound metabolic process|cellular amide metabolic process|carboxylic acid binding|response to oxygen radical|gene expression|nervous system development|folic acid-containing compound metabolic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|superoxide metabolic process|vitamin metabolic process|neuron development|neuron differentiation|regulation of transcription involved in G1/S transition of mitotic cell cycle|regulation of response to reactive oxygen species|pteridine-containing compound biosynthetic process|nucleotide metabolic process|positive regulation of monooxygenase activity|RNA biosynthetic process|mitotic cell cycle phase transition|regulation of RNA biosynthetic process|tetrahydrofolate metabolic process|folic acid metabolic process|coenzyme biosynthetic process|axon development|tetrahydrobiopterin metabolic process|amino acid binding|carboxylic acid metabolic process|poly(A) RNA binding|folic acid-containing compound biosynthetic process|dihydrofolate metabolic process|serine family amino acid metabolic process|cellular response to reactive oxygen species|neurogenesis|axon regeneration|nucleotide biosynthetic process|water-soluble vitamin metabolic process|transcription, DNA-templated|regulation of transcription, DNA-templated|dihydrofolate reductase activity|response to superoxide|positive regulation of nitric-oxide synthase activity|transcription from RNA polymerase II promoter|glycine metabolic process|dicarboxylic acid metabolic process|cellular response to superoxide|regulation of transcription from RNA polymerase II promoter|generation of neurons|mRNA binding|regulation of nucleic acid-templated transcription|tetrahydrobiopterin biosynthetic process|G1/S transition of mitotic cell cycle|regulation of nitric-oxide synthase activity|serine family amino acid biosynthetic process|tetrahydrofolate biosynthetic process|glycine biosynthetic process K00287 dihydrofolate reductase[1.5.1.3] hsa01100|hsa00670|hsa00790 Metabolic pathways - Homo sapiens (human)|One carbon pool by folate - Homo sapiens (human)|Folate biosynthesis - Homo sapiens (human) 5:80626228-80654983 438 135 540 897 1047 573 3.41370188543103 0.956238012927749 3.79454389043926 6.26385338266587 6.69523871225739 4.18538202296824 2.72149459626601 5.71482470596383 -1.07031007503568 0.00713493352989952 0.0315845648875475 DOWN ENSG00000219433 BTBD10P2 BTB (POZ) domain containing 10 pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:51541] - - - - - - 6:149794763-149795746 3 4 7 1 1 0 0.313955354022106 0.380398237154257 0.660374245266458 0.0937112329893669 0.0858923484975628 0 0.45157594548094 0.0598678604956432 2.91511502024672 0.00715088338686757 0.031636406732594 UP ENSG00000110675 ELMOD1 ELMO/CED-12 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:25334] GO:0005623|GO:0009987|GO:0008152|GO:0050794|GO:0043229|GO:0051050|GO:0051641|GO:0016043|GO:0043227|GO:0009893|GO:0030234|GO:0005622|GO:1903829|GO:0019222|GO:0060341|GO:0006810|GO:0051130|GO:0008047|GO:0051128|GO:0043231|GO:0005737|GO:0032880|GO:0051222|GO:0045184|GO:0032388|GO:0043085|GO:0008104|GO:0031647|GO:0051649|GO:0090316|GO:0050790|GO:0006996|GO:0005096|GO:0072594|GO:0051345|GO:0007005|GO:0030695|GO:0032386|GO:0051223|GO:1903955|GO:0015031|GO:0070201|GO:0046907|GO:0031981|GO:0005654|GO:0034613|GO:0033043|GO:0006626|GO:1903827|GO:0005634|GO:0010638|GO:0033365|GO:0033157|GO:0006839|GO:0043087|GO:0006605|GO:0072655|GO:0010822|GO:0016482|GO:0006886|GO:0043547|GO:0010821|GO:1903214|GO:1903533|GO:0070585 cell|cellular process|metabolic process|regulation of cellular process|intracellular organelle|positive regulation of transport|cellular localization|cellular component organization|membrane-bounded organelle|positive regulation of metabolic process|enzyme regulator activity|intracellular|positive regulation of cellular protein localization|regulation of metabolic process|regulation of cellular localization|transport|positive regulation of cellular component organization|enzyme activator activity|regulation of cellular component organization|intracellular membrane-bounded organelle|cytoplasm|regulation of protein localization|positive regulation of protein transport|establishment of protein localization|positive regulation of intracellular transport|positive regulation of catalytic activity|protein localization|regulation of protein stability|establishment of localization in cell|positive regulation of intracellular protein transport|regulation of catalytic activity|organelle organization|GTPase activator activity|establishment of protein localization to organelle|positive regulation of hydrolase activity|mitochondrion organization|GTPase regulator activity|regulation of intracellular transport|regulation of protein transport|positive regulation of protein targeting to mitochondrion|protein transport|regulation of establishment of protein localization|intracellular transport|nuclear lumen|nucleoplasm|cellular protein localization|regulation of organelle organization|protein targeting to mitochondrion|regulation of cellular protein localization|nucleus|positive regulation of organelle organization|protein localization to organelle|regulation of intracellular protein transport|mitochondrial transport|regulation of GTPase activity|protein targeting|establishment of protein localization to mitochondrion|positive regulation of mitochondrion organization|cytosolic transport|intracellular protein transport|positive regulation of GTPase activity|regulation of mitochondrion organization|regulation of protein targeting to mitochondrion|regulation of protein targeting|protein localization to mitochondrion - - - - 11:107591091-107666779 7 3 11 16 18 26 0.0633774569450409 0.02468863828172 0.0897894787900908 0.129787472609409 0.133709602678469 0.220611919886327 0.0592851913389506 0.161369665058068 -1.44462571164161 0.00720705934927382 0.0318471802565454 DOWN ENSG00000219435 TEX40 testis expressed 40 [Source:HGNC Symbol;Acc:HGNC:19231] GO:0000003|GO:0009987|GO:0022414|GO:0044702|GO:0051321|GO:0016043|GO:0007049|GO:0022402|GO:0007126|GO:0006996|GO:0007140 reproduction|cellular process|reproductive process|single organism reproductive process|meiotic cell cycle|cellular component organization|cell cycle|cell cycle process|meiotic nuclear division|organelle organization|male meiosis - - - - 11:64300446-64304770 9 13 8 28 28 20 0.486352327737154 0.638476204496389 0.389781830384804 1.35569118012172 1.24146135689432 1.01287696031716 0.504870120872782 1.20334316577773 -1.25306392088831 0.00723492934166332 0.0319466914015703 DOWN ENSG00000079263 SP140 SP140 nuclear body protein [Source:HGNC Symbol;Acc:HGNC:17133] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0006952|GO:0046483|GO:0043231|GO:0043169|GO:0005737|GO:0005635|GO:0006139|GO:0044249|GO:0031323|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0005654|GO:0005739|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0016604|GO:0046914|GO:0006351|GO:0006355|GO:1903506|GO:0016605|GO:0008270 cell|cellular process|metabolic process|response to stimulus|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|endomembrane system|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|defense response|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|nuclear envelope|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|nucleoplasm|mitochondrion|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear body|transition metal ion binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|PML body|zinc ion binding - - - - 2:230203110-230313215 0 1 1 3 4 9 0 0.00640870134883812 0.00635160201473141 0.0189428555913194 0.0231303973335535 0.0594502017885477 0.00425343445452318 0.0338411515711402 -2.99207853492719 0.00724007546746102 0.0319599605213043 DOWN ENSG00000115665 SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 [Source:HGNC Symbol;Acc:HGNC:14025] GO:0005215|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0042995|GO:0008021|GO:0022857|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0051641|GO:0045177|GO:0044297|GO:0043227|GO:0071944|GO:0009058|GO:0031224|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0012505|GO:0042133|GO:0043025|GO:0006810|GO:0016324|GO:0044853|GO:0033265|GO:0032940|GO:0031982|GO:0043231|GO:0043178|GO:0043169|GO:0030133|GO:0005737|GO:0007267|GO:0043005|GO:0043204|GO:0036477|GO:0022891|GO:0007154|GO:0055085|GO:0051649|GO:0001505|GO:0016021|GO:0044249|GO:0098857|GO:0005768|GO:0006836|GO:0030424|GO:0031410|GO:0005769|GO:0016023|GO:0070382|GO:0006811|GO:0015075|GO:0030425|GO:0031988|GO:0046903|GO:0045121|GO:0008292|GO:0042136|GO:0030139|GO:0015293|GO:0006812|GO:0015696|GO:0030135|GO:0015871|GO:0015220|GO:0008324|GO:0030136|GO:0005307|GO:0022890|GO:0030001|GO:0045334|GO:0015672|GO:0007268|GO:0007271|GO:0006814|GO:0007274|GO:0015077|GO:0046873|GO:0008519|GO:0015081 transporter activity|synapse|signaling|cell|membrane|cellular process|metabolic process|binding|small molecule binding|cell projection|synaptic vesicle|transmembrane transporter activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|cellular localization|apical part of cell|cell body|membrane-bounded organelle|cell periphery|biosynthetic process|intrinsic component of membrane|intracellular|neurotransmitter secretion|protein binding|plasma membrane|endomembrane system|neurotransmitter metabolic process|neuronal cell body|transport|apical plasma membrane|plasma membrane raft|choline binding|secretion by cell|vesicle|intracellular membrane-bounded organelle|alcohol binding|cation binding|transport vesicle|cytoplasm|cell-cell signaling|neuron projection|perikaryon|somatodendritic compartment|substrate-specific transmembrane transporter activity|cell communication|transmembrane transport|establishment of localization in cell|regulation of neurotransmitter levels|integral component of membrane|cellular biosynthetic process|membrane microdomain|endosome|neurotransmitter transport|axon|cytoplasmic vesicle|early endosome|cytoplasmic, membrane-bounded vesicle|exocytic vesicle|ion transport|ion transmembrane transporter activity|dendrite|membrane-bounded vesicle|secretion|membrane raft|acetylcholine biosynthetic process|neurotransmitter biosynthetic process|endocytic vesicle|symporter activity|cation transport|ammonium transport|coated vesicle|choline transport|choline transmembrane transporter activity|cation transmembrane transporter activity|clathrin-coated vesicle|choline:sodium symporter activity|inorganic cation transmembrane transporter activity|metal ion transport|clathrin-coated endocytic vesicle|monovalent inorganic cation transport|synaptic transmission|synaptic transmission, cholinergic|sodium ion transport|neuromuscular synaptic transmission|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|ammonium transmembrane transporter activity|sodium ion transmembrane transporter activity K14387 solute carrier family 5 (high affinity choline transporter), member 7[-] hsa04725|hsa05231 Cholinergic synapse - Homo sapiens (human)|Choline metabolism in cancer - Homo sapiens (human) 2:107986523-108013994 0 0 2 5 4 6 0 0 0.020412242597764 0.0507076658550409 0.0371478104720024 0.0636557831679806 0.00680408086592133 0.050503753165008 -2.89191841259533 0.00728687274694326 0.0321570286751285 DOWN ENSG00000162849 KIF26B kinesin family member 26B [Source:HGNC Symbol;Acc:HGNC:25484] GO:0040011|GO:0032502|GO:0040007|GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0044877|GO:0050794|GO:0043229|GO:0043167|GO:0051641|GO:0009653|GO:0016043|GO:0007155|GO:0009605|GO:0016787|GO:0048589|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048646|GO:0016337|GO:0072033|GO:0006935|GO:0035239|GO:0001822|GO:0009888|GO:0048468|GO:0006810|GO:0035295|GO:0007275|GO:0048513|GO:0072028|GO:0043168|GO:0005874|GO:0030155|GO:0001882|GO:0016817|GO:0098609|GO:0005737|GO:0006928|GO:0009887|GO:0032403|GO:0048729|GO:0072006|GO:0005875|GO:0008104|GO:0007163|GO:0051649|GO:0045785|GO:0008092|GO:0000166|GO:0030030|GO:0048869|GO:0007017|GO:0060560|GO:0015631|GO:0000902|GO:0031175|GO:0060677|GO:0005871|GO:0002009|GO:0035639|GO:0072164|GO:0001655|GO:0072273|GO:0072210|GO:0001883|GO:0000904|GO:0008017|GO:0001656|GO:0016818|GO:0046907|GO:0072001|GO:0032549|GO:0022407|GO:0030010|GO:0007018|GO:0072077|GO:0061326|GO:0060993|GO:0060429|GO:0072073|GO:0032990|GO:0007399|GO:0060562|GO:0097485|GO:0017076|GO:0030154|GO:0022409|GO:0048858|GO:0001823|GO:0072092|GO:0005856|GO:0048666|GO:0030182|GO:0007411|GO:0001657|GO:0005524|GO:0072078|GO:0030554|GO:0072163|GO:0061564|GO:0061333|GO:0015630|GO:0072080|GO:0022008|GO:0048667|GO:0030705|GO:0003338|GO:0048812|GO:0072283|GO:0016462|GO:0007409|GO:0048699|GO:0017111|GO:0060675|GO:0016887|GO:0003774|GO:0003777|GO:0008574 locomotion|developmental process|growth|macromolecular complex|cell|cellular process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|ion binding|cellular localization|anatomical structure morphogenesis|cellular component organization|cell adhesion|response to external stimulus|hydrolase activity|developmental growth|intracellular|protein binding|protein complex|anatomical structure development|anatomical structure formation involved in morphogenesis|single organismal cell-cell adhesion|renal vesicle formation|chemotaxis|tube morphogenesis|kidney development|tissue development|cell development|transport|tube development|multicellular organism development|animal organ development|nephron morphogenesis|anion binding|microtubule|regulation of cell adhesion|nucleoside binding|hydrolase activity, acting on acid anhydrides|cell-cell adhesion|cytoplasm|movement of cell or subcellular component|organ morphogenesis|protein complex binding|tissue morphogenesis|nephron development|microtubule associated complex|protein localization|establishment or maintenance of cell polarity|establishment of localization in cell|positive regulation of cell adhesion|cytoskeletal protein binding|nucleotide binding|cell projection organization|cellular developmental process|microtubule-based process|developmental growth involved in morphogenesis|tubulin binding|cell morphogenesis|neuron projection development|ureteric bud elongation|kinesin complex|morphogenesis of an epithelium|purine ribonucleoside triphosphate binding|mesonephric tubule development|urogenital system development|metanephric nephron morphogenesis|metanephric nephron development|purine nucleoside binding|cell morphogenesis involved in differentiation|microtubule binding|metanephros development|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|intracellular transport|renal system development|ribonucleoside binding|regulation of cell-cell adhesion|establishment of cell polarity|microtubule-based movement|renal vesicle morphogenesis|renal tubule development|kidney morphogenesis|epithelium development|kidney epithelium development|cell part morphogenesis|nervous system development|epithelial tube morphogenesis|neuron projection guidance|purine nucleotide binding|cell differentiation|positive regulation of cell-cell adhesion|cell projection morphogenesis|mesonephros development|ureteric bud invasion|cytoskeleton|neuron development|neuron differentiation|axon guidance|ureteric bud development|ATP binding|nephron tubule morphogenesis|adenyl nucleotide binding|mesonephric epithelium development|axon development|renal tubule morphogenesis|microtubule cytoskeleton|nephron tubule development|neurogenesis|cell morphogenesis involved in neuron differentiation|cytoskeleton-dependent intracellular transport|metanephros morphogenesis|neuron projection morphogenesis|metanephric renal vesicle morphogenesis|pyrophosphatase activity|axonogenesis|generation of neurons|nucleoside-triphosphatase activity|ureteric bud morphogenesis|ATPase activity|motor activity|microtubule motor activity|ATP-dependent microtubule motor activity, plus-end-directed - - - - 1:245154985-245709431 2 1 4 8 9 9 0.00825266164370144 0.00375205499573792 0.0148822895803788 0.0295792101770317 0.0304711563915202 0.0348058700939135 0.00896233540660605 0.0316187455541551 -1.818833507119 0.00737131487416595 0.0325056476001994 DOWN ENSG00000236256 DIAPH2-AS1 DIAPH2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:16972] - - - - - - X:97431286-97642589 0 0 2 2 7 7 0 0 0.0442442261510326 0.0439686802683557 0.140918567132732 0.160967996668203 0.0147480753836775 0.11528508135643 -2.96660722999088 0.00740318961400255 0.032622114057038 DOWN ENSG00000144908 ALDH1L1 aldehyde dehydrogenase 1 family member L1 [Source:HGNC Symbol;Acc:HGNC:3978] GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0032259|GO:0016491|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0016740|GO:0006575|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0044281|GO:0031982|GO:0046483|GO:0043231|GO:0005737|GO:0006520|GO:0016903|GO:0051186|GO:0070062|GO:0006730|GO:0055114|GO:0008168|GO:0042558|GO:0016620|GO:0009063|GO:0005739|GO:0043603|GO:0016742|GO:0006760|GO:0019439|GO:0042219|GO:0004029|GO:0047105|GO:0046653|GO:0046395|GO:0016155|GO:0019752|GO:0019145|GO:0043648|GO:0009256|GO:0009258|GO:0043649 cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|methylation|oxidoreductase activity|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|transferase activity|cellular modified amino acid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|small molecule metabolic process|vesicle|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|cellular amino acid metabolic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors|cofactor metabolic process|extracellular exosome|one-carbon metabolic process|oxidation-reduction process|methyltransferase activity|pteridine-containing compound metabolic process|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor|cellular amino acid catabolic process|mitochondrion|cellular amide metabolic process|hydroxymethyl-, formyl- and related transferase activity|folic acid-containing compound metabolic process|aromatic compound catabolic process|cellular modified amino acid catabolic process|aldehyde dehydrogenase (NAD) activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|tetrahydrofolate metabolic process|carboxylic acid catabolic process|formyltetrahydrofolate dehydrogenase activity|carboxylic acid metabolic process|aminobutyraldehyde dehydrogenase activity|dicarboxylic acid metabolic process|10-formyltetrahydrofolate metabolic process|10-formyltetrahydrofolate catabolic process|dicarboxylic acid catabolic process K00289 formyltetrahydrofolate dehydrogenase[1.5.1.6] - - 3:126103562-126197994 10 12 31 31 34 77 0.0380656349952454 0.0415158553949432 0.106397924750901 0.105731904719288 0.10619297802357 0.274708699001071 0.0619931383803632 0.162211193914643 -1.38769293402324 0.00740752924765908 0.0326363503158442 DOWN ENSG00000248919 ATP5J2-PTCD1 ATP5J2-PTCD1 readthrough [Source:HGNC Symbol;Acc:HGNC:38844] - - - - - - 7:99419749-99466197 3 4 5 3 3 97 0.0651423632040957 0.0789285476722768 0.097868902948649 0.0583519026134074 0.0534473791909528 1.97375475319002 0.0806466046083405 0.69518467833146 -3.10771058664587 0.00740860675589455 0.0326363503158442 DOWN ENSG00000263843 RP11-649A18.12 - - - - - - - 17:75271369-75273895 44 52 34 31 25 11 1.01282437084838 1.08784240420163 0.705625453802317 0.639345998533618 0.472157941676064 0.237297011358705 0.935430742950776 0.449600317189462 1.05698779036934 0.00741906437293708 0.0326727758946251 UP ENSG00000178928 TPRX1 tetra-peptide repeat homeobox 1 [Source:HGNC Symbol;Acc:HGNC:32174] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:0043565|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:47801243-47819051 1 2 6 0 0 0 0.0187660284865059 0.0340956256054466 0.101476614155471 0 0 0 0.0514460894158078 0 Inf 0.00745613215845328 0.0328214935798384 UP ENSG00000185792 NLRP9 NLR family, pyrin domain containing 9 [Source:HGNC Symbol;Acc:HGNC:22941] GO:0005623|GO:0005488|GO:0036094|GO:0097159|GO:0043167|GO:0005622|GO:0005515|GO:0043168|GO:0001882|GO:0005737|GO:0000166|GO:0035639|GO:0001883|GO:0032549|GO:0017076|GO:0005524|GO:0030554 cell|binding|small molecule binding|organic cyclic compound binding|ion binding|intracellular|protein binding|anion binding|nucleoside binding|cytoplasm|nucleotide binding|purine ribonucleoside triphosphate binding|purine nucleoside binding|ribonucleoside binding|purine nucleotide binding|ATP binding|adenyl nucleotide binding - - - - 19:55708432-55738402 6 10 10 3 4 2 0.109409996826241 0.16573163722369 0.164418798650976 0.0490101827054605 0.0598444618818106 0.0341767184210972 0.146520144233636 0.0476771210027894 1.61973000036958 0.00746514426464797 0.0328563197518503 UP ENSG00000276148 RP11-278C7.4 - - - - - - - 12:32725248-32725660 9 9 10 2 3 5 1.54148958113301 1.40100761106415 1.54426276021098 0.306929068313969 0.421626056668581 0.802661606874073 1.49558665080271 0.510405577285541 1.55099550039782 0.00747746410070917 0.0329008420431203 UP ENSG00000120211 INSL4 insulin like 4 [Source:HGNC Symbol;Acc:HGNC:6087] GO:0032502|GO:0000003|GO:0023052|GO:0009987|GO:0005576|GO:0022414|GO:0050896|GO:0005488|GO:0051716|GO:0008283|GO:0050794|GO:0005615|GO:0005515|GO:0048856|GO:0007275|GO:0005102|GO:0007267|GO:0007154|GO:0007565|GO:0007165|GO:0005159|GO:0005179 developmental process|reproduction|signaling|cellular process|extracellular region|reproductive process|response to stimulus|binding|cellular response to stimulus|cell proliferation|regulation of cellular process|extracellular space|protein binding|anatomical structure development|multicellular organism development|receptor binding|cell-cell signaling|cell communication|female pregnancy|signal transduction|insulin-like growth factor receptor binding|hormone activity - - - - 9:5231419-5235304 8 4 16 4 4 0 0.289891651426906 0.131736274752192 0.522770918005849 0.129878796325481 0.118922473175996 0 0.314799614728316 0.0829337565004923 1.92440242910802 0.00750645912708617 0.0330089601973826 UP ENSG00000248079 DPH6-AS1 DPH6 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:44147] - - - - - - 15:35546195-35859001 0 1 0 4 4 3 0 0.027486208007239 0 0.108343337789461 0.0992037041194629 0.0849817248432283 0.00916206933574633 0.0975095889173841 -3.4117987119849 0.00750846415170644 0.033012914401332 DOWN ENSG00000171989 LDHAL6B lactate dehydrogenase A-like 6B [Source:HGNC Symbol;Acc:HGNC:21481] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0016491|GO:0043229|GO:0071704|GO:0044237|GO:0043227|GO:0005622|GO:0005515|GO:0006082|GO:0044281|GO:0016614|GO:0043231|GO:0005737|GO:0005975|GO:0055114|GO:0004457|GO:0016616|GO:0005739|GO:0005634|GO:0004459|GO:0019752 cell|cellular process|metabolic process|binding|catalytic activity|oxidoreductase activity|intracellular organelle|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intracellular|protein binding|organic acid metabolic process|small molecule metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|cytoplasm|carbohydrate metabolic process|oxidation-reduction process|lactate dehydrogenase activity|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|mitochondrion|nucleus|L-lactate dehydrogenase activity|carboxylic acid metabolic process K00016 L-lactate dehydrogenase[1.1.1.27] hsa01100|hsa04922|hsa00010|hsa00270|hsa00620|hsa00640 Metabolic pathways - Homo sapiens (human)|Glucagon signaling pathway - Homo sapiens (human)|Glycolysis / Gluconeogenesis - Homo sapiens (human)|Cysteine and methionine metabolism - Homo sapiens (human)|Pyruvate metabolism - Homo sapiens (human)|Propanoate metabolism - Homo sapiens (human) 15:59206823-59208515 0 1 1 7 4 4 0 0.0379903879131361 0.0376519065681302 0.262040111719917 0.137115574506523 0.156611329894195 0.0252140981604221 0.185255672040212 -2.87721518466483 0.00754022790387292 0.0331184292838344 DOWN ENSG00000257551 HLX-AS1 HLX antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:42509] - - - - - - 1:220832763-220880140 1 0 1 4 4 7 0.125695725439811 0 0.11322322880967 0.450308011416232 0.412320901668816 0.824281943862217 0.0796396514164937 0.562303618982422 -2.81979052058941 0.00755039575280567 0.0331484580594501 DOWN ENSG00000039987 BEST2 bestrophin 2 [Source:HGNC Symbol;Acc:HGNC:17107] GO:0032991|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0042995|GO:0022857|GO:0071944|GO:0031224|GO:0005886|GO:0043234|GO:0005929|GO:0042391|GO:0006810|GO:0050877|GO:0005887|GO:0022891|GO:0031226|GO:1902495|GO:0055085|GO:0016021|GO:0051899|GO:0015267|GO:0006811|GO:0015075|GO:0007600|GO:0034702|GO:0034220|GO:0006820|GO:0005216|GO:0098656|GO:0034707|GO:0008509|GO:0007606|GO:0007608|GO:0005253|GO:0015698|GO:0005254|GO:1902476|GO:0006821|GO:0015108 macromolecular complex|transporter activity|cell|membrane|cellular process|cell projection|transmembrane transporter activity|cell periphery|intrinsic component of membrane|plasma membrane|protein complex|cilium|regulation of membrane potential|transport|neurological system process|integral component of plasma membrane|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|transmembrane transport|integral component of membrane|membrane depolarization|channel activity|ion transport|ion transmembrane transporter activity|sensory perception|ion channel complex|ion transmembrane transport|anion transport|ion channel activity|anion transmembrane transport|chloride channel complex|anion transmembrane transporter activity|sensory perception of chemical stimulus|sensory perception of smell|anion channel activity|inorganic anion transport|chloride channel activity|chloride transmembrane transport|chloride transport|chloride transmembrane transporter activity K13879 bestrophin-2[-] hsa04970 Salivary secretion - Homo sapiens (human) 19:12751702-12758458 12 3 3 1 1 1 0.183380647294638 0.0416704106491852 0.0413265892878098 0.0136852005834547 0.0125433630555957 0.0143196684764999 0.088792549077211 0.0135160773718501 2.71576210534341 0.00755650194514765 0.0331606363472641 UP ENSG00000228878 SEPT7-AS1 SEPT7 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:51153] - - - - - - 7:35751856-35800616 7 6 10 10 20 43 0.114489727424648 0.0891846965258767 0.147463704038644 0.146545323946439 0.268379528218879 0.65910743005639 0.117046042663056 0.358010760740569 -1.61292679364201 0.00756353526441577 0.0331817460373061 DOWN ENSG00000064201 TSPAN32 tetraspanin 32 [Source:HGNC Symbol;Acc:HGNC:13410] GO:0032991|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0002683|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0006950|GO:0009986|GO:0016043|GO:0051707|GO:0007155|GO:0071944|GO:0009607|GO:0009605|GO:0031224|GO:0005622|GO:0002682|GO:0005886|GO:0043234|GO:0042127|GO:0050817|GO:0016337|GO:0001562|GO:0098797|GO:0050688|GO:0006952|GO:0098542|GO:0098609|GO:0005887|GO:0007267|GO:0009611|GO:0043235|GO:0009615|GO:0001775|GO:0031226|GO:0050865|GO:0007154|GO:0007165|GO:0002695|GO:0008285|GO:0051607|GO:0016021|GO:0050878|GO:0006996|GO:0030885|GO:0030168|GO:0007166|GO:0007010|GO:0007596|GO:0034109|GO:0042060|GO:0030886|GO:0007599|GO:0008305|GO:0042832|GO:0001773|GO:0070527|GO:0070442|GO:0007229 macromolecular complex|immune system process|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|negative regulation of immune system process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|response to stress|cell surface|cellular component organization|response to other organism|cell adhesion|cell periphery|response to biotic stimulus|response to external stimulus|intrinsic component of membrane|intracellular|regulation of immune system process|plasma membrane|protein complex|regulation of cell proliferation|coagulation|single organismal cell-cell adhesion|response to protozoan|plasma membrane protein complex|regulation of defense response to virus|defense response|defense response to other organism|cell-cell adhesion|integral component of plasma membrane|cell-cell signaling|response to wounding|receptor complex|response to virus|cell activation|intrinsic component of plasma membrane|regulation of cell activation|cell communication|signal transduction|negative regulation of leukocyte activation|negative regulation of cell proliferation|defense response to virus|integral component of membrane|regulation of body fluid levels|organelle organization|regulation of myeloid dendritic cell activation|platelet activation|cell surface receptor signaling pathway|cytoskeleton organization|blood coagulation|homotypic cell-cell adhesion|wound healing|negative regulation of myeloid dendritic cell activation|hemostasis|integrin complex|defense response to protozoan|myeloid dendritic cell activation|platelet aggregation|integrin alphaIIb-beta3 complex|integrin-mediated signaling pathway - - - - 11:2301997-2318200 0 0 1 1 5 8 0 0 0.00748352639350135 0.00743705018793285 0.0340690179882479 0.0622630288532691 0.00249450879783378 0.0345896990098166 -3.79351479714376 0.00756523067912166 0.0331843074778869 DOWN ENSG00000092931 MFSD11 major facilitator superfamily domain containing 11 [Source:HGNC Symbol;Acc:HGNC:25458] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 17:76735865-76781449 193 705 310 879 1103 646 0.87452483044074 2.90324632569354 1.26645712203903 3.56862968126016 4.10070298273323 2.74331886407254 1.68140942605777 3.47088384268864 -1.04563201839545 0.00760547772951569 0.0333314639073637 DOWN ENSG00000099985 OSM oncostatin M [Source:HGNC Symbol;Acc:HGNC:8506] GO:0032502|GO:0040007|GO:0000003|GO:0002376|GO:0007610|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0008283|GO:0050794|GO:0006807|GO:0006950|GO:0044702|GO:0051321|GO:0071704|GO:0006955|GO:0009628|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0044708|GO:0040008|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:0008284|GO:0051726|GO:0042127|GO:0007049|GO:0048266|GO:0006725|GO:0006810|GO:0022402|GO:1901360|GO:0010941|GO:0007275|GO:0051302|GO:0005102|GO:0034641|GO:0032940|GO:0006952|GO:0031325|GO:0046483|GO:0051128|GO:0010942|GO:0045786|GO:0007267|GO:0009611|GO:0009408|GO:0009966|GO:0051782|GO:0051445|GO:0046883|GO:0010646|GO:0006139|GO:0007154|GO:0033555|GO:0007165|GO:0007126|GO:0046888|GO:0008219|GO:0008285|GO:0051048|GO:1903531|GO:0051781|GO:0051301|GO:0010817|GO:0009967|GO:0044249|GO:0009266|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0051447|GO:0006996|GO:0000165|GO:1902533|GO:2001235|GO:0032268|GO:0040020|GO:0010468|GO:0005126|GO:0034645|GO:0007166|GO:0043412|GO:0034097|GO:0050727|GO:0051252|GO:0005125|GO:0010628|GO:0036211|GO:0006954|GO:0051046|GO:0010564|GO:0009914|GO:0051247|GO:0050729|GO:0045835|GO:0032270|GO:0012501|GO:0006796|GO:0048265|GO:0035556|GO:0033043|GO:0044267|GO:0051174|GO:0010467|GO:0007399|GO:0046903|GO:0071310|GO:0031328|GO:0051246|GO:0009059|GO:0043068|GO:1902531|GO:0016070|GO:0008083|GO:0010557|GO:0043067|GO:0097190|GO:0010948|GO:0007422|GO:0045893|GO:0002673|GO:0019221|GO:0031401|GO:0043065|GO:0043408|GO:0032774|GO:2001141|GO:0002675|GO:0016310|GO:0002526|GO:0005147|GO:0043410|GO:0042981|GO:0071345|GO:0006464|GO:0046879|GO:0006351|GO:0006915|GO:0006355|GO:0045944|GO:0006366|GO:0007259|GO:0006357|GO:0006468|GO:1903506|GO:0046425|GO:0038165|GO:0042325|GO:0001932|GO:0018193|GO:0046427|GO:0001934|GO:0042327|GO:0050731|GO:0050730|GO:0033138|GO:0007260|GO:0018105|GO:0042531|GO:0033135|GO:0018108|GO:0042516|GO:0042517|GO:0042506|GO:0042508|GO:0042503 developmental process|growth|reproduction|immune system process|behavior|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|response to stress|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|immune response|response to abiotic stimulus|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|single-organism behavior|regulation of growth|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|extracellular space|intracellular|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell cycle|regulation of cell proliferation|cell cycle|behavioral response to pain|cellular aromatic compound metabolic process|transport|cell cycle process|organic cyclic compound metabolic process|regulation of cell death|multicellular organism development|regulation of cell division|receptor binding|cellular nitrogen compound metabolic process|secretion by cell|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|positive regulation of cell death|negative regulation of cell cycle|cell-cell signaling|response to wounding|response to heat|regulation of signal transduction|negative regulation of cell division|regulation of meiotic cell cycle|regulation of hormone secretion|regulation of cell communication|nucleobase-containing compound metabolic process|cell communication|multicellular organismal response to stress|signal transduction|meiotic nuclear division|negative regulation of hormone secretion|cell death|negative regulation of cell proliferation|negative regulation of secretion|negative regulation of secretion by cell|positive regulation of cell division|cell division|regulation of hormone levels|positive regulation of signal transduction|cellular biosynthetic process|response to temperature stimulus|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|negative regulation of meiotic cell cycle|organelle organization|MAPK cascade|positive regulation of intracellular signal transduction|positive regulation of apoptotic signaling pathway|regulation of cellular protein metabolic process|regulation of meiotic nuclear division|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|cell surface receptor signaling pathway|macromolecule modification|response to cytokine|regulation of inflammatory response|regulation of RNA metabolic process|cytokine activity|positive regulation of gene expression|protein modification process|inflammatory response|regulation of secretion|regulation of cell cycle process|hormone transport|positive regulation of protein metabolic process|positive regulation of inflammatory response|negative regulation of meiotic nuclear division|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|response to pain|intracellular signal transduction|regulation of organelle organization|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|nervous system development|secretion|cellular response to organic substance|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|positive regulation of programmed cell death|regulation of intracellular signal transduction|RNA metabolic process|growth factor activity|positive regulation of macromolecule biosynthetic process|regulation of programmed cell death|apoptotic signaling pathway|negative regulation of cell cycle process|peripheral nervous system development|positive regulation of transcription, DNA-templated|regulation of acute inflammatory response|cytokine-mediated signaling pathway|positive regulation of protein modification process|positive regulation of apoptotic process|regulation of MAPK cascade|RNA biosynthetic process|regulation of RNA biosynthetic process|positive regulation of acute inflammatory response|phosphorylation|acute inflammatory response|oncostatin-M receptor binding|positive regulation of MAPK cascade|regulation of apoptotic process|cellular response to cytokine stimulus|cellular protein modification process|hormone secretion|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|JAK-STAT cascade|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|regulation of nucleic acid-templated transcription|regulation of JAK-STAT cascade|oncostatin-M-mediated signaling pathway|regulation of phosphorylation|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of JAK-STAT cascade|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|positive regulation of peptidyl-serine phosphorylation|tyrosine phosphorylation of STAT protein|peptidyl-serine phosphorylation|positive regulation of tyrosine phosphorylation of STAT protein|regulation of peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat3 protein|tyrosine phosphorylation of Stat5 protein|tyrosine phosphorylation of Stat1 protein|tyrosine phosphorylation of Stat3 protein K05418 oncostatin M[-] hsa04151|hsa04060|hsa04630 PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human) 22:30262829-30266840 11 6 11 3 0 5 0.245071597765123 0.121487814952572 0.220952818200623 0.0598773224297579 0 0.104409210594958 0.195837410306106 0.0547621776749053 1.83840466239552 0.00761148020738398 0.0333479791768772 UP ENSG00000249635 RP11-710F7.3 - - - - - - - 4:106003317-106022478 0 0 1 4 3 4 0 0 0.0180784679012605 0.0719011373872203 0.0493850145785945 0.0751965347450007 0.00602615596708683 0.0654942289036052 -3.44205786967122 0.00763234646220348 0.0334001863504284 DOWN ENSG00000241326 RP11-807G9.2 - - - - - - - 1:9983141-9984568 0 0 0 8 4 0 0 0 0 1.16295142397862 0.53242354963198 0 0 0.565124991203533 -Inf 0.00764291880557418 0.0334366497687004 DOWN ENSG00000089116 LHX5 LIM homeobox 5 [Source:HGNC Symbol;Acc:HGNC:14216] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0008283|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0008284|GO:0042127|GO:0006725|GO:0021692|GO:0021766|GO:0021697|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0021587|GO:0030902|GO:0030900|GO:0031325|GO:0046483|GO:0007420|GO:0043231|GO:0043169|GO:0007267|GO:0060322|GO:0006139|GO:0021696|GO:0021695|GO:0007154|GO:0022037|GO:0061351|GO:0021694|GO:0021543|GO:0021549|GO:0048869|GO:0021537|GO:0044249|GO:0021516|GO:0021680|GO:0031323|GO:0021575|GO:0021534|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0007417|GO:0051252|GO:0021510|GO:0021761|GO:0010628|GO:0021527|GO:0021533|GO:0021846|GO:0021872|GO:0021702|GO:0010467|GO:0021937|GO:2000179|GO:0007399|GO:0031328|GO:0009059|GO:0030154|GO:0021940|GO:2000177|GO:0016070|GO:0010557|GO:0005634|GO:0051960|GO:0030182|GO:0021953|GO:0045893|GO:0032774|GO:0043565|GO:2001141|GO:0021936|GO:0021515|GO:0046914|GO:0021879|GO:0022008|GO:0006351|GO:0006355|GO:0048699|GO:1903506|GO:0021930|GO:0008270 developmental process|signaling|cell|cellular process|metabolic process|binding|organic cyclic compound binding|cell proliferation|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|cellular aromatic compound metabolic process|cerebellar Purkinje cell layer morphogenesis|hippocampus development|cerebellar cortex formation|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|cerebellum morphogenesis|hindbrain development|forebrain development|positive regulation of cellular metabolic process|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|cation binding|cell-cell signaling|head development|nucleobase-containing compound metabolic process|cerebellar cortex morphogenesis|cerebellar cortex development|cell communication|metencephalon development|neural precursor cell proliferation|cerebellar Purkinje cell layer formation|pallium development|cerebellum development|cellular developmental process|telencephalon development|cellular biosynthetic process|dorsal spinal cord development|cerebellar Purkinje cell layer development|regulation of cellular metabolic process|hindbrain morphogenesis|cell proliferation in hindbrain|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|central nervous system development|regulation of RNA metabolic process|spinal cord development|limbic system development|positive regulation of gene expression|spinal cord association neuron differentiation|cell differentiation in hindbrain|cell proliferation in forebrain|forebrain generation of neurons|cerebellar Purkinje cell differentiation|gene expression|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|positive regulation of neural precursor cell proliferation|nervous system development|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|positive regulation of cerebellar granule cell precursor proliferation|regulation of neural precursor cell proliferation|RNA metabolic process|positive regulation of macromolecule biosynthetic process|nucleus|regulation of nervous system development|neuron differentiation|central nervous system neuron differentiation|positive regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|regulation of cerebellar granule cell precursor proliferation|cell differentiation in spinal cord|transition metal ion binding|forebrain neuron differentiation|neurogenesis|transcription, DNA-templated|regulation of transcription, DNA-templated|generation of neurons|regulation of nucleic acid-templated transcription|cerebellar granule cell precursor proliferation|zinc ion binding K18493 LIM homeobox protein 5[-] hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) 12:113462034-113472280 11 23 14 8 7 5 0.213061972317707 0.404884548870884 0.244494175233842 0.138840860036878 0.111245407733753 0.0907719725188916 0.287480232140811 0.113619413429841 1.33925339607908 0.00770061971295794 0.0336504561222167 UP ENSG00000269741 CTC-518B2.8 - GO:0008152|GO:0003824|GO:0071704|GO:0016787|GO:0008233|GO:0019538|GO:0017171|GO:0006508|GO:0008236|GO:0004252|GO:0004175 metabolic process|catalytic activity|organic substance metabolic process|hydrolase activity|peptidase activity|protein metabolic process|serine hydrolase activity|proteolysis|serine-type peptidase activity|serine-type endopeptidase activity|endopeptidase activity - - - - 19:50996018-51009581 3 9 7 21 9 31 0.103076162855242 0.281018039518939 0.216810582710114 0.646413718133806 0.253684586140573 0.998125387912029 0.200301595028098 0.632741230728803 -1.65944169834422 0.0077424739671908 0.0338127293470618 DOWN ENSG00000135116 HRK harakiri, BCL2 interacting protein [Source:HGNC Symbol;Acc:HGNC:5185] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0044089|GO:0023051|GO:0016043|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0051130|GO:0010941|GO:0051128|GO:0022607|GO:0010942|GO:0043231|GO:0005737|GO:0009966|GO:0010646|GO:0007154|GO:0007165|GO:0008219|GO:0016021|GO:0009967|GO:0031334|GO:0043254|GO:0006996|GO:2001235|GO:0007005|GO:0032461|GO:0032459|GO:0005739|GO:0006461|GO:0012501|GO:0033043|GO:0043068|GO:0043067|GO:0097190|GO:0010638|GO:0043065|GO:0051259|GO:0032464|GO:0008637|GO:0010822|GO:0090200|GO:0010821|GO:0001836|GO:0042981|GO:0006915|GO:0051260 signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|positive regulation of cellular component biogenesis|regulation of signaling|cellular component organization|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|positive regulation of cellular component organization|regulation of cell death|regulation of cellular component organization|cellular component assembly|positive regulation of cell death|intracellular membrane-bounded organelle|cytoplasm|regulation of signal transduction|regulation of cell communication|cell communication|signal transduction|cell death|integral component of membrane|positive regulation of signal transduction|positive regulation of protein complex assembly|regulation of protein complex assembly|organelle organization|positive regulation of apoptotic signaling pathway|mitochondrion organization|positive regulation of protein oligomerization|regulation of protein oligomerization|mitochondrion|protein complex assembly|programmed cell death|regulation of organelle organization|positive regulation of programmed cell death|regulation of programmed cell death|apoptotic signaling pathway|positive regulation of organelle organization|positive regulation of apoptotic process|protein oligomerization|positive regulation of protein homooligomerization|apoptotic mitochondrial changes|positive regulation of mitochondrion organization|positive regulation of release of cytochrome c from mitochondria|regulation of mitochondrion organization|release of cytochrome c from mitochondria|regulation of apoptotic process|apoptotic process|protein homooligomerization K02512 activator of apoptosis harakiri[-] hsa04210 Apoptosis - Homo sapiens (human) 12:116856144-116881441 28 44 100 27 32 26 0.264786901537101 0.378160600465115 0.852629906813352 0.228776866481085 0.248290051312061 0.230433279421374 0.498525802938523 0.235833399071507 1.0799001288882 0.00775219833268133 0.0338403463991619 UP ENSG00000136237 RAPGEF5 Rap guanine nucleotide exchange factor 5 [Source:HGNC Symbol;Acc:HGNC:16862] GO:0032502|GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0043227|GO:0009893|GO:0005622|GO:0005515|GO:0005085|GO:0048856|GO:0019222|GO:0007275|GO:0043231|GO:0030742|GO:0005088|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0051345|GO:0017034|GO:0035556|GO:0007399|GO:0005634|GO:0043087|GO:0043547|GO:0007264 developmental process|signaling|cell|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|membrane-bounded organelle|positive regulation of metabolic process|intracellular|protein binding|guanyl-nucleotide exchange factor activity|anatomical structure development|regulation of metabolic process|multicellular organism development|intracellular membrane-bounded organelle|GTP-dependent protein binding|Ras guanyl-nucleotide exchange factor activity|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|positive regulation of hydrolase activity|Rap guanyl-nucleotide exchange factor activity|intracellular signal transduction|nervous system development|nucleus|regulation of GTPase activity|positive regulation of GTPase activity|small GTPase mediated signal transduction K08019 Rap guanine nucleotide exchange factor 5[-] hsa04014|hsa04015 Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human) 7:22118238-22357144 37 56 127 124 176 169 0.125184924690556 0.172195385106801 0.387409909807458 0.375901336891918 0.488578506353236 0.535882781070569 0.228263406534938 0.466787541438574 -1.03206645989415 0.0077591821526098 0.0338609302710149 DOWN ENSG00000130234 ACE2 angiotensin I converting enzyme 2 [Source:HGNC Symbol;Acc:HGNC:13557] GO:0040011|GO:0007610|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:1903561|GO:0044406|GO:0007631|GO:0004872|GO:0008283|GO:0050794|GO:0006807|GO:0006950|GO:0044089|GO:0071704|GO:0009056|GO:0043167|GO:0009986|GO:0044237|GO:0042445|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0016787|GO:0009058|GO:0031224|GO:0005615|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0016032|GO:0042127|GO:0006810|GO:0051130|GO:0050877|GO:0042756|GO:0034641|GO:0006952|GO:0001618|GO:1901890|GO:0031982|GO:0031325|GO:0051128|GO:0022607|GO:0001817|GO:0043169|GO:0008233|GO:0005737|GO:0003012|GO:0001816|GO:0016486|GO:0009611|GO:0072593|GO:1901888|GO:1903524|GO:0044236|GO:0070062|GO:0007586|GO:0008217|GO:0002005|GO:0001948|GO:0010817|GO:0016021|GO:1903779|GO:0019538|GO:0098857|GO:0031323|GO:0003013|GO:0051701|GO:0019062|GO:0044259|GO:0035150|GO:0003051|GO:0006936|GO:0045216|GO:0006518|GO:0046872|GO:0043171|GO:0030163|GO:0061337|GO:0044254|GO:0050727|GO:0044268|GO:0051604|GO:0045823|GO:0090257|GO:0045989|GO:2000377|GO:0001976|GO:0006811|GO:0006954|GO:0034329|GO:0006508|GO:0002002|GO:0043603|GO:0044267|GO:0010467|GO:0019058|GO:0051246|GO:0009059|GO:0045121|GO:0008015|GO:0002003|GO:0003073|GO:1903598|GO:2000379|GO:0043112|GO:0006941|GO:0008237|GO:0008016|GO:0006820|GO:0015711|GO:0042312|GO:0006937|GO:0016485|GO:0003081|GO:0032800|GO:0046718|GO:0060047|GO:0006812|GO:0019229|GO:0060452|GO:0002035|GO:0046942|GO:0004175|GO:0008238|GO:0046914|GO:0006865|GO:0060177|GO:0030260|GO:0046813|GO:0007043|GO:0050880|GO:0016264|GO:0004180|GO:0006942|GO:0042311|GO:0015801|GO:0060048|GO:0015827|GO:0001991|GO:0042310|GO:0002016|GO:0055117|GO:0008241|GO:0008270 locomotion|behavior|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|extracellular vesicle|adhesion of symbiont to host|feeding behavior|receptor activity|cell proliferation|regulation of cellular process|nitrogen compound metabolic process|response to stress|positive regulation of cellular component biogenesis|organic substance metabolic process|catabolic process|ion binding|cell surface|cellular metabolic process|hormone metabolic process|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|hydrolase activity|biosynthetic process|intrinsic component of membrane|extracellular space|intracellular|protein binding|plasma membrane|regulation of metabolic process|viral process|regulation of cell proliferation|transport|positive regulation of cellular component organization|neurological system process|drinking behavior|cellular nitrogen compound metabolic process|defense response|virus receptor activity|positive regulation of cell junction assembly|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|regulation of cytokine production|cation binding|peptidase activity|cytoplasm|muscle system process|cytokine production|peptide hormone processing|response to wounding|reactive oxygen species metabolic process|regulation of cell junction assembly|positive regulation of blood circulation|multicellular organism metabolic process|extracellular exosome|digestion|regulation of blood pressure|angiotensin catabolic process in blood|glycoprotein binding|regulation of hormone levels|integral component of membrane|regulation of cardiac conduction|protein metabolic process|membrane microdomain|regulation of cellular metabolic process|circulatory system process|interaction with host|virion attachment to host cell|multicellular organismal macromolecule metabolic process|regulation of tube size|angiotensin-mediated drinking behavior|muscle contraction|cell-cell junction organization|peptide metabolic process|metal ion binding|peptide catabolic process|protein catabolic process|cardiac conduction|multicellular organismal protein catabolic process|regulation of inflammatory response|multicellular organismal protein metabolic process|protein maturation|positive regulation of heart contraction|regulation of muscle system process|positive regulation of striated muscle contraction|regulation of reactive oxygen species metabolic process|neurological system process involved in regulation of systemic arterial blood pressure|ion transport|inflammatory response|cell junction assembly|proteolysis|regulation of angiotensin levels in blood|cellular amide metabolic process|cellular protein metabolic process|gene expression|viral life cycle|regulation of protein metabolic process|macromolecule biosynthetic process|membrane raft|blood circulation|angiotensin maturation|regulation of systemic arterial blood pressure|positive regulation of gap junction assembly|positive regulation of reactive oxygen species metabolic process|receptor metabolic process|striated muscle contraction|metallopeptidase activity|regulation of heart contraction|anion transport|organic anion transport|regulation of vasodilation|regulation of muscle contraction|protein processing|regulation of systemic arterial blood pressure by renin-angiotensin|receptor biosynthetic process|viral entry into host cell|heart contraction|cation transport|regulation of vasoconstriction|positive regulation of cardiac muscle contraction|brain renin-angiotensin system|carboxylic acid transport|endopeptidase activity|exopeptidase activity|transition metal ion binding|amino acid transport|regulation of angiotensin metabolic process|entry into host cell|receptor-mediated virion attachment to host cell|cell-cell junction assembly|regulation of blood vessel size|gap junction assembly|carboxypeptidase activity|regulation of striated muscle contraction|vasodilation|aromatic amino acid transport|cardiac muscle contraction|tryptophan transport|regulation of systemic arterial blood pressure by circulatory renin-angiotensin|vasoconstriction|regulation of blood volume by renin-angiotensin|regulation of cardiac muscle contraction|peptidyl-dipeptidase activity|zinc ion binding K09708 angiotensin-converting enzyme 2[3.4.17.23] hsa04974|hsa04614 Protein digestion and absorption - Homo sapiens (human)|Renin-angiotensin system - Homo sapiens (human) X:15561033-15602148 7 1 13 16 22 26 0.0950236175612367 0.0123426840792438 0.159102149641222 0.194594036364865 0.245033182635839 0.330769704485104 0.0888228170939008 0.256798974495269 -1.53163720770495 0.00782000549943685 0.0340909355708524 DOWN ENSG00000077327 SPAG6 sperm associated antigen 6 [Source:HGNC Symbol;Acc:HGNC:11215] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0042995|GO:0043229|GO:0044702|GO:0019953|GO:0003006|GO:0016043|GO:0043227|GO:0032504|GO:0005622|GO:0005515|GO:0048856|GO:0005929|GO:0048609|GO:0048468|GO:0005930|GO:0005874|GO:0043231|GO:0031514|GO:0048515|GO:0007276|GO:0030030|GO:0048869|GO:0007281|GO:0007286|GO:0048232|GO:0030154|GO:0005856|GO:0005634|GO:0007283|GO:0015630 developmental process|reproduction|cell|cellular process|reproductive process|binding|cell projection|intracellular organelle|single organism reproductive process|sexual reproduction|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|intracellular|protein binding|anatomical structure development|cilium|multicellular organismal reproductive process|cell development|axoneme|microtubule|intracellular membrane-bounded organelle|motile cilium|spermatid differentiation|gamete generation|cell projection organization|cellular developmental process|germ cell development|spermatid development|male gamete generation|cell differentiation|cytoskeleton|nucleus|spermatogenesis|microtubule cytoskeleton - - - - 10:22345445-22454224 0 0 0 3 3 2 0 0 0 0.0233264415600591 0.0213658357551073 0.0162664405834891 0 0.0203195726328852 -Inf 0.00783983773915448 0.0341032370486257 DOWN ENSG00000143942 CHAC2 ChaC, cation transport regulator homolog 2 (E. coli) [Source:HGNC Symbol;Acc:HGNC:32363] GO:0008152|GO:0003824|GO:0016740|GO:0016746 metabolic process|catalytic activity|transferase activity|transferase activity, transferring acyl groups - - - - 2:53767792-53775196 227 309 150 136 177 52 12.1553980243344 15.0377038357989 7.24181741566395 6.52496242503353 7.77651329289285 2.60960019692941 11.4783064252657 5.63702530495193 1.02590384531596 0.00783280070226689 0.0341032370486257 UP ENSG00000170683 OR10A3 olfactory receptor family 10 subfamily A member 3 [Source:HGNC Symbol;Acc:HGNC:8162] GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0051716|GO:0004872|GO:0051606|GO:0050794|GO:0038023|GO:0071944|GO:0031224|GO:0005886|GO:0050877|GO:0004888|GO:0050906|GO:0007154|GO:0009593|GO:0007165|GO:0016021|GO:0007186|GO:0050907|GO:0007600|GO:0004984|GO:0004930|GO:0050911|GO:0007606|GO:0007608 signal transducer activity|signaling|cell|membrane|cellular process|response to stimulus|cellular response to stimulus|receptor activity|detection of stimulus|regulation of cellular process|signaling receptor activity|cell periphery|intrinsic component of membrane|plasma membrane|neurological system process|transmembrane signaling receptor activity|detection of stimulus involved in sensory perception|cell communication|detection of chemical stimulus|signal transduction|integral component of membrane|G-protein coupled receptor signaling pathway|detection of chemical stimulus involved in sensory perception|sensory perception|olfactory receptor activity|G-protein coupled receptor activity|detection of chemical stimulus involved in sensory perception of smell|sensory perception of chemical stimulus|sensory perception of smell - - - - 11:7938534-7939594 0 0 0 2 4 2 0 0 0 0.119473803217408 0.218790450178646 0.124949567158752 0 0.154404606851602 -Inf 0.00783983773915448 0.0341032370486257 DOWN ENSG00000224899 RP11-3B12.5 - - - - - - - 7:125151326-125153611 0 0 0 2 4 2 0 0 0 0.211269508689449 0.386894446065905 0.220952484592394 0 0.273038813115916 -Inf 0.00783983773915448 0.0341032370486257 DOWN ENSG00000228804 RP11-211G3.3 - - - - - - - 3:187702313-187733849 2 2 4 0 0 0 0.158773429737744 0.144303708370526 0.286321221085134 0 0 0 0.196466119731135 0 Inf 0.00783983773915448 0.0341032370486257 UP ENSG00000231039 RP11-445P17.3 - - - - - - - 10:5234358-5263408 0 0 0 2 3 3 0 0 0 0.186414272373043 0.2560758255943 0.292437111960521 0 0.244975736642621 -Inf 0.00783983773915448 0.0341032370486257 DOWN ENSG00000231333 RPL34P6 ribosomal protein L34 pseudogene 6 [Source:HGNC Symbol;Acc:HGNC:35810] - - - - - - 1:200863808-200864152 2 6 9 1 1 1 0.410049640279218 1.11804003615773 1.66367853273494 0.183619691306702 0.168299210389427 0.192132595297734 1.06392273639063 0.181350498997954 2.55254076394313 0.00783250691190368 0.0341032370486257 UP ENSG00000235748 SEPT14P12 septin 14 pseudogene 12 [Source:HGNC Symbol;Acc:HGNC:51699] - - - - - - 1:197138748-197139307 0 0 0 3 3 2 0 0 0 0.339483033418717 0.310949216793079 0.236734804920422 0 0.295722351710739 -Inf 0.00783983773915448 0.0341032370486257 DOWN ENSG00000251138 RP11-81H3.2 - - - - - - - 12:74133166-74402535 0 0 0 2 3 3 0 0 0 0.0380437290557231 0.0522603725702653 0.0596810432572492 0 0.0499950482944125 -Inf 0.00783983773915448 0.0341032370486257 DOWN ENSG00000271749 RP11-269G24.7 - - - - - - - 17:63393355-63393586 0 0 0 2 4 2 0 0 0 0.546386660403747 1.0005890846532 0.571428839463087 0 0.706134861506678 -Inf 0.00783983773915448 0.0341032370486257 DOWN ENSG00000279170 RP1-199J3.6 - - - - - - - 6:99587611-99589898 0 0 0 3 2 3 0 0 0 0.083090252934651 0.0507291668792708 0.0869131276805744 0 0.0735775158314987 -Inf 0.00783983773915448 0.0341032370486257 DOWN ENSG00000260253 RP4-676L2.1 - - - - - - - 8:29352420-29353170 2 0 0 7 7 2 0.188371672298709 0 0 0.590724246527058 0.540969679152686 0.176526618848783 0.062790557432903 0.436073514842842 -2.79595184499566 0.00784424139978571 0.0341074836512092 DOWN ENSG00000178750 STX19 syntaxin 19 [Source:HGNC Symbol;Acc:HGNC:19300] GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0031629|GO:0008021|GO:0043229|GO:0016079|GO:0051641|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0031201|GO:0051640|GO:0006810|GO:0032940|GO:0031982|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0051656|GO:0022406|GO:0005484|GO:0045184|GO:0000149|GO:0008104|GO:0007154|GO:0061024|GO:0051649|GO:0001505|GO:0016021|GO:0006996|GO:0061025|GO:0016192|GO:0006836|GO:0051650|GO:0048278|GO:0016050|GO:0031410|GO:0015031|GO:0048489|GO:0016023|GO:0006887|GO:0070382|GO:0046907|GO:0031988|GO:0034613|GO:0046903|GO:0051648|GO:0048284|GO:0045055|GO:0045026|GO:0016482|GO:0006886|GO:0006906|GO:0017156|GO:0007268 macromolecular complex|synapse|signaling|cell|membrane|cellular process|binding|synaptic vesicle fusion to presynaptic active zone membrane|synaptic vesicle|intracellular organelle|synaptic vesicle exocytosis|cellular localization|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|neurotransmitter secretion|protein binding|plasma membrane|protein complex|endomembrane system|SNARE complex|organelle localization|transport|secretion by cell|vesicle|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|establishment of organelle localization|membrane docking|SNAP receptor activity|establishment of protein localization|SNARE binding|protein localization|cell communication|membrane organization|establishment of localization in cell|regulation of neurotransmitter levels|integral component of membrane|organelle organization|membrane fusion|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|vesicle docking|vesicle organization|cytoplasmic vesicle|protein transport|synaptic vesicle transport|cytoplasmic, membrane-bounded vesicle|exocytosis|exocytic vesicle|intracellular transport|membrane-bounded vesicle|cellular protein localization|secretion|vesicle localization|organelle fusion|regulated exocytosis|plasma membrane fusion|cytosolic transport|intracellular protein transport|vesicle fusion|calcium ion regulated exocytosis|synaptic transmission K08487 syntaxin 11[-] hsa04130 SNARE interactions in vesicular transport - Homo sapiens (human) 3:94014369-94028610 26 16 24 47 57 40 1.58820284766942 0.888252878467281 1.32176727078358 2.57236951226525 2.8567797397105 2.2899675292407 1.26607433230676 2.57303892707215 -1.02311117441446 0.00786232725558922 0.0341662180332402 DOWN ENSG00000272682 AC004471.10 - - - - - - - 22:19124309-19128449 5 5 3 0 0 2 0.233620175175214 0.212329547591293 0.126354545451302 0 0 0.0875637323351626 0.190768089405936 0.0291879107783875 2.70837701179493 0.00788269711947444 0.0342348035793992 UP ENSG00000271643 RP11-10C24.3 - - - - - - - 3:33795688-33796950 18 0 0 0 0 0 1.00813174506403 0 0 0 0 0 0.336043915021343 0 Inf 0.00790062725553558 0.0343026943116287 UP ENSG00000242779 ZNF702P zinc finger protein 702, pseudogene [Source:HGNC Symbol;Acc:HGNC:25775] - - - - - - 19:52968251-53037898 2 8 3 13 22 10 0.0162121391125751 0.0589386221215398 0.0219230783650323 0.0944211580085754 0.146329121558028 0.0759715758110913 0.0323579465330491 0.105573951792565 -1.70606196224131 0.00793728472766012 0.0344418166074949 DOWN ENSG00000214973 CHCHD3P3 coiled-coil-helix-coiled-coil-helix domain containing 3 pseudogene 3 [Source:HGNC Symbol;Acc:HGNC:44699] - - - - - - 1:27200834-27201473 11 12 11 32 37 17 1.21578487953791 1.20538691398255 1.09613312154216 3.16894244563541 3.35532731099704 1.76093547644064 1.17243497168754 2.76173507769103 -1.23606702735603 0.007955461272824 0.0344906100550229 DOWN ENSG00000269392 CTB-191K22.6 - - - - - - - 19:50365880-50369331 4 6 5 1 0 2 0.930704775633751 1.26882833050795 1.04887133489046 0.208384189147408 0 0.436090430116566 1.08280148034405 0.214824873087991 2.33353581723756 0.0079844770553155 0.0345712223363871 UP ENSG00000095637 SORBS1 sorbin and SH3 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:14565] GO:0032991|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0030055|GO:0044877|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0005911|GO:0016043|GO:0007155|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0031224|GO:0005622|GO:1903829|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0035591|GO:0060341|GO:0044262|GO:0006810|GO:0051130|GO:0098797|GO:0005102|GO:0015980|GO:0005924|GO:0044281|GO:0005912|GO:0031325|GO:0051128|GO:0022607|GO:0005887|GO:0043231|GO:0010243|GO:0005737|GO:0003012|GO:0032880|GO:0043235|GO:0005975|GO:0032403|GO:0031589|GO:0009966|GO:0045184|GO:0030674|GO:0010828|GO:0010646|GO:0031226|GO:0008104|GO:0007154|GO:0061024|GO:0006629|GO:0007165|GO:0005913|GO:0090004|GO:0008092|GO:0009725|GO:0006091|GO:0016021|GO:0030029|GO:0009967|GO:0044249|GO:0010033|GO:0098857|GO:0031323|GO:0043296|GO:0010256|GO:0006996|GO:0055114|GO:0051017|GO:0006109|GO:0005829|GO:0005813|GO:0005976|GO:0046326|GO:0006936|GO:0034645|GO:0045216|GO:0090150|GO:0007166|GO:0007010|GO:0005899|GO:0005815|GO:0003779|GO:1901652|GO:0046889|GO:0071417|GO:0007009|GO:0032432|GO:0070201|GO:0007160|GO:0005158|GO:0034329|GO:0033692|GO:0072657|GO:0031981|GO:0043434|GO:1990234|GO:0005977|GO:0005996|GO:0005654|GO:0016363|GO:0030036|GO:0034613|GO:0042641|GO:0006112|GO:0043467|GO:1903078|GO:0008610|GO:0019216|GO:0071310|GO:0046890|GO:0031328|GO:0009059|GO:0034399|GO:0045121|GO:0005915|GO:1903827|GO:0008643|GO:0005070|GO:0032870|GO:0005856|GO:0010557|GO:0005634|GO:0016051|GO:0005925|GO:0010827|GO:0005978|GO:0015629|GO:0019318|GO:0090003|GO:1901653|GO:0000271|GO:0034332|GO:0072659|GO:0090002|GO:0046324|GO:0045725|GO:0010906|GO:0007167|GO:0001725|GO:0007044|GO:0015630|GO:0071375|GO:0048041|GO:0032868|GO:1903076|GO:0031032|GO:0030038|GO:0007015|GO:0070873|GO:1990778|GO:0010907|GO:0034333|GO:0005979|GO:0008645|GO:1902911|GO:0006006|GO:0032869|GO:0043149|GO:0061572|GO:0007169|GO:0015758|GO:0008286|GO:0046323 macromolecular complex|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|binding, bridging|cellular response to stimulus|cell-substrate junction|macromolecular complex binding|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|cell-cell junction|cellular component organization|cell adhesion|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intrinsic component of membrane|intracellular|positive regulation of cellular protein localization|protein binding|plasma membrane|protein complex|regulation of metabolic process|signaling adaptor activity|regulation of cellular localization|cellular carbohydrate metabolic process|transport|positive regulation of cellular component organization|plasma membrane protein complex|receptor binding|energy derivation by oxidation of organic compounds|cell-substrate adherens junction|small molecule metabolic process|adherens junction|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular component assembly|integral component of plasma membrane|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|muscle system process|regulation of protein localization|receptor complex|carbohydrate metabolic process|protein complex binding|cell-substrate adhesion|regulation of signal transduction|establishment of protein localization|protein binding, bridging|positive regulation of glucose transport|regulation of cell communication|intrinsic component of plasma membrane|protein localization|cell communication|membrane organization|lipid metabolic process|signal transduction|cell-cell adherens junction|positive regulation of establishment of protein localization to plasma membrane|cytoskeletal protein binding|response to hormone|generation of precursor metabolites and energy|integral component of membrane|actin filament-based process|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|membrane microdomain|regulation of cellular metabolic process|apical junction complex|endomembrane system organization|organelle organization|oxidation-reduction process|actin filament bundle assembly|regulation of carbohydrate metabolic process|cytosol|centrosome|polysaccharide metabolic process|positive regulation of glucose import|muscle contraction|cellular macromolecule biosynthetic process|cell-cell junction organization|establishment of protein localization to membrane|cell surface receptor signaling pathway|cytoskeleton organization|insulin receptor complex|microtubule organizing center|actin binding|response to peptide|positive regulation of lipid biosynthetic process|cellular response to organonitrogen compound|plasma membrane organization|actin filament bundle|regulation of establishment of protein localization|cell-matrix adhesion|insulin receptor binding|cell junction assembly|cellular polysaccharide biosynthetic process|protein localization to membrane|nuclear lumen|response to peptide hormone|transferase complex|glycogen metabolic process|monosaccharide metabolic process|nucleoplasm|nuclear matrix|actin cytoskeleton organization|cellular protein localization|actomyosin|energy reserve metabolic process|regulation of generation of precursor metabolites and energy|positive regulation of protein localization to plasma membrane|lipid biosynthetic process|regulation of lipid metabolic process|cellular response to organic substance|regulation of lipid biosynthetic process|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|nuclear periphery|membrane raft|zonula adherens|regulation of cellular protein localization|carbohydrate transport|SH3/SH2 adaptor activity|cellular response to hormone stimulus|cytoskeleton|positive regulation of macromolecule biosynthetic process|nucleus|carbohydrate biosynthetic process|focal adhesion|regulation of glucose transport|glycogen biosynthetic process|actin cytoskeleton|hexose metabolic process|regulation of establishment of protein localization to plasma membrane|cellular response to peptide|polysaccharide biosynthetic process|adherens junction organization|protein localization to plasma membrane|establishment of protein localization to plasma membrane|regulation of glucose import|positive regulation of glycogen biosynthetic process|regulation of glucose metabolic process|enzyme linked receptor protein signaling pathway|stress fiber|cell-substrate junction assembly|microtubule cytoskeleton|cellular response to peptide hormone stimulus|focal adhesion assembly|response to insulin|regulation of protein localization to plasma membrane|actomyosin structure organization|contractile actin filament bundle assembly|actin filament organization|regulation of glycogen metabolic process|protein localization to cell periphery|positive regulation of glucose metabolic process|adherens junction assembly|regulation of glycogen biosynthetic process|hexose transport|protein kinase complex|glucose metabolic process|cellular response to insulin stimulus|stress fiber assembly|actin filament bundle organization|transmembrane receptor protein tyrosine kinase signaling pathway|glucose transport|insulin receptor signaling pathway|glucose import K06086 sorbin and SH3 domain containing 1[-] hsa04910|hsa04520|hsa03320 Insulin signaling pathway - Homo sapiens (human)|Adherens junction - Homo sapiens (human)|PPAR signaling pathway - Homo sapiens (human) 10:95311771-95561414 15 13 65 70 50 159 0.0516646333299374 0.0406955909668293 0.201853886023069 0.216026267032884 0.141300224450557 0.513257697488183 0.0980713701066119 0.290194729657208 -1.56511738002101 0.00799502206353868 0.0345917954615774 DOWN ENSG00000214954 LRRC69 leucine rich repeat containing 69 [Source:HGNC Symbol;Acc:HGNC:34303] GO:0005488|GO:0005515 binding|protein binding - - - - 8:91101832-91219236 14 13 22 37 33 37 0.219440758303392 0.185190638529974 0.310890847678697 0.519608989393932 0.424390164280648 0.543508674047679 0.238507414837354 0.495835942574086 -1.05582873636013 0.00799488755358564 0.0345917954615774 DOWN ENSG00000205209 SCGB2B2 secretoglobin, family 2B, member 2 [Source:HGNC Symbol;Acc:HGNC:27616] GO:0005576 extracellular region - - - - 19:34593329-34675699 2 0 0 6 8 2 0.0437843162786537 0 0 0.117698890634791 0.143711376238941 0.0410311020598688 0.0145947720928846 0.100813789644534 -2.78816940146622 0.00803682916057856 0.0347525344379943 DOWN ENSG00000133808 MICALCL MICAL C-terminal like [Source:HGNC Symbol;Acc:HGNC:25933] GO:0032502|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0005488|GO:0044702|GO:0019953|GO:0032504|GO:0005622|GO:0005515|GO:0048856|GO:0048609|GO:0007275|GO:0019899|GO:0005737|GO:0007276|GO:0048869|GO:0048232|GO:0019900|GO:0030154|GO:0007283|GO:0019901|GO:0051019 developmental process|reproduction|cell|cellular process|reproductive process|binding|single organism reproductive process|sexual reproduction|multicellular organism reproduction|intracellular|protein binding|anatomical structure development|multicellular organismal reproductive process|multicellular organism development|enzyme binding|cytoplasm|gamete generation|cellular developmental process|male gamete generation|kinase binding|cell differentiation|spermatogenesis|protein kinase binding|mitogen-activated protein kinase binding - - - - 11:12276080-12359144 4 7 13 12 19 46 0.0731285220451435 0.116319860225215 0.214288266161904 0.196580571538386 0.285018442313577 0.788187353612572 0.134578882810754 0.423262122488178 -1.6530993384274 0.00803957020513888 0.034759352484318 DOWN ENSG00000270190 RP11-803D5.4 - - - - - - - 2:111266868-111267473 1 0 0 4 5 3 0.116776721819495 0 0 0.418355462751384 0.478877714890917 0.328147254345139 0.0389255739398317 0.408460143995813 -3.39140509602995 0.00805703045925121 0.0348247556580984 DOWN ENSG00000111012 CYP27B1 cytochrome P450 family 27 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2606] GO:0032502|GO:0040007|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0008283|GO:0016491|GO:0050794|GO:0043229|GO:0006950|GO:0016049|GO:0044702|GO:0071704|GO:0009056|GO:0043167|GO:0006955|GO:0044237|GO:0003006|GO:0023051|GO:0045926|GO:0016043|GO:0051707|GO:0043227|GO:0019867|GO:0040008|GO:0009607|GO:0009605|GO:0009893|GO:0032504|GO:0009058|GO:0050793|GO:0005622|GO:0048856|GO:0031090|GO:0048609|GO:0019222|GO:0001893|GO:0046697|GO:0042127|GO:0007049|GO:0001890|GO:0045087|GO:0045595|GO:0009888|GO:0045684|GO:0006810|GO:0022402|GO:1901360|GO:0009991|GO:0007275|GO:0009410|GO:0048513|GO:0044281|GO:0006952|GO:0051128|GO:0045597|GO:0043231|GO:0048608|GO:0043169|GO:0030308|GO:0005737|GO:0016705|GO:0031668|GO:0042592|GO:0009966|GO:0031966|GO:0009890|GO:0060135|GO:0010646|GO:0043085|GO:0009617|GO:0004497|GO:0007154|GO:0044092|GO:0007565|GO:0006629|GO:0007165|GO:0030278|GO:0001503|GO:0009725|GO:0006805|GO:0030656|GO:0008285|GO:0050790|GO:0045833|GO:0043086|GO:0048869|GO:0009967|GO:0044249|GO:0010033|GO:0001558|GO:0031324|GO:0031323|GO:0055114|GO:0007584|GO:0070562|GO:0005740|GO:0051354|GO:0045682|GO:0046872|GO:0020037|GO:0033993|GO:0061458|GO:0034097|GO:0002237|GO:0016042|GO:0005741|GO:0048878|GO:0006066|GO:0016709|GO:0010957|GO:0031214|GO:0051055|GO:0070564|GO:0031670|GO:0030856|GO:0006811|GO:0033273|GO:0034341|GO:0071466|GO:0045939|GO:0030858|GO:0005739|GO:0043588|GO:0051353|GO:0008202|GO:0051341|GO:0014070|GO:0060429|GO:0070314|GO:0008610|GO:0019216|GO:0071310|GO:0045606|GO:0046890|GO:0030154|GO:0031669|GO:0031667|GO:0032496|GO:0030282|GO:0048545|GO:0097305|GO:0030522|GO:0030500|GO:0006766|GO:0033280|GO:0030855|GO:0042359|GO:0070561|GO:0042369|GO:0019218|GO:0006812|GO:0030216|GO:0046164|GO:0043627|GO:0008544|GO:0071407|GO:0045604|GO:0004498|GO:0006694|GO:0010956|GO:0006706|GO:0045618|GO:0071295|GO:0050810|GO:0010894|GO:0046914|GO:0050801|GO:0010980|GO:0071396|GO:0036378|GO:0060558|GO:0032769|GO:0045616|GO:0005506|GO:0030001|GO:0071305|GO:0009913|GO:0055065|GO:0006816|GO:0055074 developmental process|growth|reproduction|immune system process|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|oxidoreductase activity|regulation of cellular process|intracellular organelle|response to stress|cell growth|single organism reproductive process|organic substance metabolic process|catabolic process|ion binding|immune response|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|negative regulation of growth|cellular component organization|response to other organism|membrane-bounded organelle|outer membrane|regulation of growth|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|multicellular organism reproduction|biosynthetic process|regulation of developmental process|intracellular|anatomical structure development|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|maternal placenta development|decidualization|regulation of cell proliferation|cell cycle|placenta development|innate immune response|regulation of cell differentiation|tissue development|positive regulation of epidermis development|transport|cell cycle process|organic cyclic compound metabolic process|response to extracellular stimulus|multicellular organism development|response to xenobiotic stimulus|animal organ development|small molecule metabolic process|defense response|regulation of cellular component organization|positive regulation of cell differentiation|intracellular membrane-bounded organelle|reproductive structure development|cation binding|negative regulation of cell growth|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|cellular response to extracellular stimulus|homeostatic process|regulation of signal transduction|mitochondrial membrane|negative regulation of biosynthetic process|maternal process involved in female pregnancy|regulation of cell communication|positive regulation of catalytic activity|response to bacterium|monooxygenase activity|cell communication|negative regulation of molecular function|female pregnancy|lipid metabolic process|signal transduction|regulation of ossification|ossification|response to hormone|xenobiotic metabolic process|regulation of vitamin metabolic process|negative regulation of cell proliferation|regulation of catalytic activity|negative regulation of lipid metabolic process|negative regulation of catalytic activity|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|regulation of cell growth|negative regulation of cellular metabolic process|regulation of cellular metabolic process|oxidation-reduction process|response to nutrient|regulation of vitamin D receptor signaling pathway|mitochondrial envelope|negative regulation of oxidoreductase activity|regulation of epidermis development|metal ion binding|heme binding|response to lipid|reproductive system development|response to cytokine|response to molecule of bacterial origin|lipid catabolic process|mitochondrial outer membrane|chemical homeostasis|alcohol metabolic process|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|negative regulation of vitamin D biosynthetic process|biomineral tissue development|negative regulation of lipid biosynthetic process|positive regulation of vitamin D receptor signaling pathway|cellular response to nutrient|regulation of epithelial cell differentiation|ion transport|response to vitamin|response to interferon-gamma|cellular response to xenobiotic stimulus|negative regulation of steroid metabolic process|positive regulation of epithelial cell differentiation|mitochondrion|skin development|positive regulation of oxidoreductase activity|steroid metabolic process|regulation of oxidoreductase activity|response to organic cyclic compound|epithelium development|G1 to G0 transition|lipid biosynthetic process|regulation of lipid metabolic process|cellular response to organic substance|positive regulation of epidermal cell differentiation|regulation of lipid biosynthetic process|cell differentiation|cellular response to nutrient levels|response to nutrient levels|response to lipopolysaccharide|bone mineralization|response to steroid hormone|response to alcohol|intracellular receptor signaling pathway|regulation of bone mineralization|vitamin metabolic process|response to vitamin D|epithelial cell differentiation|vitamin D metabolic process|vitamin D receptor signaling pathway|vitamin D catabolic process|regulation of steroid metabolic process|cation transport|keratinocyte differentiation|alcohol catabolic process|response to estrogen|epidermis development|cellular response to organic cyclic compound|regulation of epidermal cell differentiation|calcidiol 1-monooxygenase activity|steroid biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|steroid catabolic process|positive regulation of keratinocyte differentiation|cellular response to vitamin|regulation of steroid biosynthetic process|negative regulation of steroid biosynthetic process|transition metal ion binding|ion homeostasis|positive regulation of vitamin D 24-hydroxylase activity|cellular response to lipid|calcitriol biosynthetic process from calciol|regulation of calcidiol 1-monooxygenase activity|negative regulation of monooxygenase activity|regulation of keratinocyte differentiation|iron ion binding|metal ion transport|cellular response to vitamin D|epidermal cell differentiation|metal ion homeostasis|calcium ion transport|calcium ion homeostasis K07438 25-hydroxyvitamin D3 1alpha-hydroxylase[1.14.13.13] hsa01100|hsa05152|hsa00100 Metabolic pathways - Homo sapiens (human)|Tuberculosis - Homo sapiens (human)|Steroid biosynthesis - Homo sapiens (human) 12:57762334-57768986 13 18 13 2 8 8 0.160763889650454 0.202302698850219 0.144944283528043 0.022161137275117 0.0811768280818216 0.0927196642958298 0.169336957342905 0.0653525432175895 1.37358158675407 0.00807406089452383 0.0348882637060522 UP ENSG00000197121 PGAP1 post-GPI attachment to proteins 1 [Source:HGNC Symbol;Acc:HGNC:25712] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0003824|GO:0043229|GO:0006807|GO:0042175|GO:0071704|GO:0044237|GO:0051641|GO:0043227|GO:0016787|GO:0009058|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0048856|GO:0031090|GO:0044255|GO:0006725|GO:0006810|GO:1901360|GO:0007275|GO:0048513|GO:0050877|GO:0034641|GO:0016788|GO:0030900|GO:0019637|GO:0046483|GO:0007420|GO:0043231|GO:0005737|GO:0007389|GO:0060322|GO:0045184|GO:0006139|GO:0008104|GO:0006629|GO:0005783|GO:0051649|GO:0016021|GO:0044249|GO:0019538|GO:0008654|GO:0034645|GO:0046486|GO:0043412|GO:0007417|GO:0009798|GO:0009880|GO:0015031|GO:0009790|GO:0006643|GO:0036211|GO:0046907|GO:0021871|GO:0003002|GO:0007600|GO:0042157|GO:0004518|GO:0034613|GO:0006796|GO:1901137|GO:0044267|GO:0008610|GO:0007399|GO:0009059|GO:0042578|GO:0006644|GO:0050954|GO:0046474|GO:0015791|GO:0009247|GO:0006886|GO:0006664|GO:0009948|GO:0042158|GO:0009952|GO:0090305|GO:0006464|GO:0006650|GO:0015798|GO:0006506|GO:0007605|GO:0046488|GO:0006661|GO:0006505|GO:0016255|GO:0043687|GO:0006497|GO:0006501 developmental process|cell|membrane|cellular process|metabolic process|catalytic activity|intracellular organelle|nitrogen compound metabolic process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|cellular metabolic process|cellular localization|membrane-bounded organelle|hydrolase activity|biosynthetic process|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|anatomical structure development|organelle membrane|cellular lipid metabolic process|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|multicellular organism development|animal organ development|neurological system process|cellular nitrogen compound metabolic process|hydrolase activity, acting on ester bonds|forebrain development|organophosphate metabolic process|heterocycle metabolic process|brain development|intracellular membrane-bounded organelle|cytoplasm|pattern specification process|head development|establishment of protein localization|nucleobase-containing compound metabolic process|protein localization|lipid metabolic process|endoplasmic reticulum|establishment of localization in cell|integral component of membrane|cellular biosynthetic process|protein metabolic process|phospholipid biosynthetic process|cellular macromolecule biosynthetic process|glycerolipid metabolic process|macromolecule modification|central nervous system development|axis specification|embryonic pattern specification|protein transport|embryo development|membrane lipid metabolic process|protein modification process|intracellular transport|forebrain regionalization|regionalization|sensory perception|lipoprotein metabolic process|nuclease activity|cellular protein localization|phosphate-containing compound metabolic process|carbohydrate derivative biosynthetic process|cellular protein metabolic process|lipid biosynthetic process|nervous system development|macromolecule biosynthetic process|phosphoric ester hydrolase activity|phospholipid metabolic process|sensory perception of mechanical stimulus|glycerophospholipid biosynthetic process|polyol transport|glycolipid biosynthetic process|intracellular protein transport|glycolipid metabolic process|anterior/posterior axis specification|lipoprotein biosynthetic process|anterior/posterior pattern specification|nucleic acid phosphodiester bond hydrolysis|cellular protein modification process|glycerophospholipid metabolic process|myo-inositol transport|GPI anchor biosynthetic process|sensory perception of sound|phosphatidylinositol metabolic process|phosphatidylinositol biosynthetic process|GPI anchor metabolic process|attachment of GPI anchor to protein|post-translational protein modification|protein lipidation|C-terminal protein lipidation K05294 glycosylphosphatidylinositol deacylase [EC:3.-.-.-][-] hsa01100|hsa00563 Metabolic pathways - Homo sapiens (human)|Glycosylphosphatidylinositol(GPI)-anchor biosynthesis - Homo sapiens (human) 2:196833004-196927796 73 127 319 287 351 510 0.185487338213915 0.293276259517213 0.730798447296906 0.653388971412304 0.731758201028011 1.2144818832451 0.403187348342678 0.866543018561805 -1.10382100307788 0.008078623056066 0.0349027158188134 DOWN ENSG00000281450 PANDAR promoter of CDKN1A antisense DNA damage activated RNA [Source:HGNC Symbol;Acc:HGNC:44048] - - - - - - 6:36673621-36675126 6 8 6 2 4 0 0.281807023697869 0.341499612637819 0.254095824688102 0.0841711189997805 0.154141213572074 0 0.29246748700793 0.0794374441906182 1.88038514059889 0.00807974372023244 0.0349027158188134 UP ENSG00000279329 CTD-2553L13.9 - - - - - - - 19:34675717-34677581 3 7 6 8 22 21 0.113798294540989 0.241309136306357 0.205184081490767 0.271874970967656 0.684647675450592 0.746456668328624 0.186763837446038 0.567659771582291 -1.60381136845573 0.00811796279736312 0.0350373950198755 DOWN ENSG00000223718 AC093107.7 - - - - - - - 7:135660039-135660647 5 11 1 0 2 0 0.580789729417527 1.16123275456098 0.104671063743587 0 0.190588397076801 0 0.615564515907365 0.063529465692267 3.27641227952672 0.00814456927671323 0.0351420683895067 UP ENSG00000156486 KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 [Source:HGNC Symbol;Acc:HGNC:6301] GO:0032991|GO:0005215|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0022857|GO:0050794|GO:0016043|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0006810|GO:0098797|GO:0022607|GO:0005887|GO:0005737|GO:0007267|GO:0022891|GO:0031226|GO:1902495|GO:0007154|GO:0055085|GO:0071804|GO:0016021|GO:0015267|GO:0006811|GO:0015075|GO:0008076|GO:0048471|GO:0034765|GO:0034702|GO:0006461|GO:0043269|GO:0071805|GO:0022898|GO:0034220|GO:0098655|GO:0005216|GO:1901379|GO:0051259|GO:0034703|GO:0006812|GO:0032412|GO:0008324|GO:1901016|GO:0005244|GO:0043266|GO:0034705|GO:0022890|GO:0030001|GO:0005261|GO:2001257|GO:0051260|GO:0015672|GO:0007268|GO:1902259|GO:0006813|GO:0022843|GO:0015077|GO:0046873|GO:0005267|GO:0015079|GO:0005249|GO:0005251 macromolecular complex|transporter activity|signaling|cell|membrane|cellular process|binding|transmembrane transporter activity|regulation of cellular process|cellular component organization|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|protein complex|transport|plasma membrane protein complex|cellular component assembly|integral component of plasma membrane|cytoplasm|cell-cell signaling|substrate-specific transmembrane transporter activity|intrinsic component of plasma membrane|transmembrane transporter complex|cell communication|transmembrane transport|cellular potassium ion transport|integral component of membrane|channel activity|ion transport|ion transmembrane transporter activity|voltage-gated potassium channel complex|perinuclear region of cytoplasm|regulation of ion transmembrane transport|ion channel complex|protein complex assembly|regulation of ion transport|potassium ion transmembrane transport|regulation of transmembrane transporter activity|ion transmembrane transport|cation transmembrane transport|ion channel activity|regulation of potassium ion transmembrane transport|protein oligomerization|cation channel complex|cation transport|regulation of ion transmembrane transporter activity|cation transmembrane transporter activity|regulation of potassium ion transmembrane transporter activity|voltage-gated ion channel activity|regulation of potassium ion transport|potassium channel complex|inorganic cation transmembrane transporter activity|metal ion transport|cation channel activity|regulation of cation channel activity|protein homooligomerization|monovalent inorganic cation transport|synaptic transmission|regulation of delayed rectifier potassium channel activity|potassium ion transport|voltage-gated cation channel activity|monovalent inorganic cation transmembrane transporter activity|metal ion transmembrane transporter activity|potassium channel activity|potassium ion transmembrane transporter activity|voltage-gated potassium channel activity|delayed rectifier potassium channel activity - - - - 8:98427022-98432848 0 2 2 9 7 4 0 0.0134506333463897 0.0133440845269826 0.059671054959252 0.0425011224023085 0.0277375229114837 0.00893157262445743 0.0433032334243481 -2.27748862907648 0.00816489456329073 0.0352195870961539 DOWN ENSG00000276302 RP5-874C20.8 - - - - - - - 6:28267121-28281580 4 6 3 0 0 2 0.507960954744453 0.692502356327499 0.343448441316466 0 0 0.238009857729688 0.514637250796139 0.0793366192432293 2.69749706030106 0.00817096554897807 0.0352355923009087 UP ENSG00000100478 AP4S1 adaptor related protein complex 4, sigma 1 subunit [Source:HGNC Symbol;Acc:HGNC:575] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0043229|GO:0051641|GO:0016043|GO:0043227|GO:0005905|GO:0005622|GO:0012505|GO:0031090|GO:0008565|GO:0006810|GO:0043231|GO:0005737|GO:0045184|GO:0008104|GO:0061024|GO:0051649|GO:0005794|GO:0005768|GO:0016192|GO:0005802|GO:0015031|GO:0046907|GO:0031904|GO:0000139|GO:0048193|GO:0032588|GO:0006892 transporter activity|cell|membrane|cellular process|intracellular organelle|cellular localization|cellular component organization|membrane-bounded organelle|coated pit|intracellular|endomembrane system|organelle membrane|protein transporter activity|transport|intracellular membrane-bounded organelle|cytoplasm|establishment of protein localization|protein localization|membrane organization|establishment of localization in cell|Golgi apparatus|endosome|vesicle-mediated transport|trans-Golgi network|protein transport|intracellular transport|endosome lumen|Golgi membrane|Golgi vesicle transport|trans-Golgi network membrane|post-Golgi vesicle-mediated transport K12403 AP-4 complex subunit sigma-1[-] hsa04142 Lysosome - Homo sapiens (human) 14:31025106-31096450 59 50 26 138 139 61 0.294776512665206 0.227035252433499 0.117118420932393 0.617759363517655 0.569805152796228 0.285628202097303 0.212976728677033 0.491064239470395 -1.20521596554764 0.00819273105986434 0.035293765232495 DOWN ENSG00000250155 CTD-2353F22.1 - - - - - - - 5:36666214-36725195 0 0 0 2 2 4 0 0 0 0.07251813799409 0.0664006486383133 0.151683627866632 0 0.0968674714996784 -Inf 0.00820669598557863 0.0353338541718035 DOWN ENSG00000259287 RP11-3D4.2 - - - - - - - 15:33858602-33864825 3 0 2 9 7 6 0.377640247898477 0 0.226968156571934 1.01493881557916 0.722897204704035 0.707802471559983 0.20153613482347 0.815212830614393 -2.01613822539185 0.00820677111366267 0.0353338541718035 DOWN ENSG00000111879 FAM184A family with sequence similarity 184 member A [Source:HGNC Symbol;Acc:HGNC:20991] GO:0005576|GO:0005488|GO:0005615|GO:0005515 extracellular region|binding|extracellular space|protein binding - - - - 6:118959763-119149387 0 4 5 5 16 14 0 0.0231332501184129 0.0286844985432438 0.0285059557330111 0.0835376746947739 0.0834959939536575 0.0172725828872189 0.0651798747938142 -1.91594274572258 0.00822952368554704 0.0354164912942657 DOWN ENSG00000243244 STON1 stonin 1 [Source:HGNC Symbol;Acc:HGNC:17003] GO:0005623|GO:0016020|GO:0009987|GO:0050794|GO:0016043|GO:0005622|GO:0006810|GO:0060627|GO:0051128|GO:0005737|GO:0016192|GO:0030100|GO:0006897 cell|membrane|cellular process|regulation of cellular process|cellular component organization|intracellular|transport|regulation of vesicle-mediated transport|regulation of cellular component organization|cytoplasm|vesicle-mediated transport|regulation of endocytosis|endocytosis - - - - 2:48529383-48598513 3 9 7 8 13 59 0.0174047744234004 0.0474508892381085 0.0366092332130659 0.0415816648232473 0.0618724971709843 0.32076042271102 0.0338216322915249 0.141404861568417 -2.06381352801867 0.00823526136881128 0.0354258635309066 DOWN ENSG00000248590 GLDCP1 glycine dehydrogenase (decarboxylase) pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:4314] - - - - - - 4:56593004-56595681 0 0 0 4 2 2 0 0 0 0.0946689359325388 0.0433414241298624 0.0495039173844048 0 0.0625047591489353 -Inf 0.0082331001972367 0.0354258635309066 DOWN ENSG00000132718 SYT11 synaptotagmin 11 [Source:HGNC Symbol;Acc:HGNC:19239] GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0030672|GO:0008021|GO:0048523|GO:0050794|GO:0043229|GO:0043167|GO:0051051|GO:0051641|GO:0023051|GO:0043227|GO:0008289|GO:0071944|GO:0023057|GO:0031224|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0012505|GO:0031090|GO:0060341|GO:0050804|GO:0006810|GO:0043168|GO:0032940|GO:0005543|GO:0031982|GO:0030276|GO:0005887|GO:0043231|GO:0043169|GO:0030133|GO:0005737|GO:0007267|GO:0012506|GO:0030658|GO:0010646|GO:0000149|GO:0031226|GO:0007154|GO:0051649|GO:0001505|GO:0051048|GO:1903531|GO:0046929|GO:0050805|GO:0016021|GO:0051589|GO:0046928|GO:0006836|GO:0046872|GO:0031410|GO:0016023|GO:0070382|GO:0051046|GO:0031988|GO:0005544|GO:0030659|GO:0046903|GO:0019905|GO:0005509|GO:0007268 synapse|signaling|cell|membrane|cellular process|cell junction|binding|synaptic vesicle membrane|synaptic vesicle|negative regulation of cellular process|regulation of cellular process|intracellular organelle|ion binding|negative regulation of transport|cellular localization|regulation of signaling|membrane-bounded organelle|lipid binding|cell periphery|negative regulation of signaling|intrinsic component of membrane|intracellular|neurotransmitter secretion|protein binding|plasma membrane|endomembrane system|organelle membrane|regulation of cellular localization|modulation of synaptic transmission|transport|anion binding|secretion by cell|phospholipid binding|vesicle|clathrin binding|integral component of plasma membrane|intracellular membrane-bounded organelle|cation binding|transport vesicle|cytoplasm|cell-cell signaling|vesicle membrane|transport vesicle membrane|regulation of cell communication|SNARE binding|intrinsic component of plasma membrane|cell communication|establishment of localization in cell|regulation of neurotransmitter levels|negative regulation of secretion|negative regulation of secretion by cell|negative regulation of neurotransmitter secretion|negative regulation of synaptic transmission|integral component of membrane|negative regulation of neurotransmitter transport|regulation of neurotransmitter secretion|neurotransmitter transport|metal ion binding|cytoplasmic vesicle|cytoplasmic, membrane-bounded vesicle|exocytic vesicle|regulation of secretion|membrane-bounded vesicle|calcium-dependent phospholipid binding|cytoplasmic vesicle membrane|secretion|syntaxin binding|calcium ion binding|synaptic transmission - - - - 1:155859509-155885199 11 12 7 3 7 0 0.148492809714554 0.147222829188709 0.0851933186641461 0.0362806295256644 0.0775321047793258 0 0.12696965252247 0.0379375781016634 1.74278422787718 0.00826966498864977 0.0355636097048618 UP ENSG00000178440 LINC00843 long intergenic non-protein coding RNA 843 [Source:HGNC Symbol;Acc:HGNC:45009] - - - - - - 10:49972763-49982053 8 7 6 18 15 27 0.508874553583921 0.404713614398702 0.344126179838382 1.0258913927257 0.782913386395402 1.60964629087194 0.419238115940335 1.13948368999768 -1.44253848104044 0.00828145844701557 0.0356040697691824 DOWN ENSG00000280120 RP11-546D6.3 - - - - - - - 12:123152324-123153377 19 21 31 34 65 55 1.27511463613813 1.28089541586179 1.87579339442244 2.04448279926028 3.57920530855102 3.45933500595532 1.47726781547412 3.02767437125554 -1.03527865313576 0.00828829581818892 0.0356283345365316 DOWN ENSG00000235545 RP11-230B22.1 - - - - - - - 1:62688482-62710694 0 0 1 7 3 2 0 0 0.051909346758831 0.361265398323958 0.141800945768831 0.107957240028857 0.017303115586277 0.203674528040549 -3.55716182817386 0.00832509390458839 0.0357694456600353 DOWN ENSG00000261159 RP11-723O4.9 - - - - - - - 3:128859716-128860526 15 14 10 5 7 4 1.30830650394195 1.10976846992228 0.786412478381178 0.390717884005118 0.500947261459516 0.326933392738437 1.0681624840818 0.406199512734357 1.3948707058806 0.00832591538459119 0.0357694456600353 UP ENSG00000172748 ZNF596 zinc finger protein 596 [Source:HGNC Symbol;Acc:HGNC:27268] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 8:232137-247342 6 8 10 27 9 37 0.0392274126711332 0.0475365945681261 0.0589500434390549 0.15817089946192 0.0482795602979424 0.226717316385727 0.0485713502261047 0.144389258715196 -1.57178592520769 0.00835327580166712 0.0358818267313626 DOWN ENSG00000130055 GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:25974] GO:0005623|GO:0016020|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0071704|GO:0043167|GO:0071944|GO:0016787|GO:0031224|GO:0005622|GO:0005886|GO:0016788|GO:0043169|GO:0005737|GO:0006629|GO:0016021|GO:0046872|GO:0005856|GO:0042578|GO:0008081|GO:0047394|GO:0008889 cell|membrane|metabolic process|binding|catalytic activity|intracellular organelle|organic substance metabolic process|ion binding|cell periphery|hydrolase activity|intrinsic component of membrane|intracellular|plasma membrane|hydrolase activity, acting on ester bonds|cation binding|cytoplasm|lipid metabolic process|integral component of membrane|metal ion binding|cytoskeleton|phosphoric ester hydrolase activity|phosphoric diester hydrolase activity|glycerophosphoinositol inositolphosphodiesterase activity|glycerophosphodiester phosphodiesterase activity - - - - X:70423031-70433390 1 0 0 5 3 3 0.0177582668563648 0 0 0.0795162368703013 0.0436967531754389 0.0499014394311554 0.00591942228545493 0.0577048098256319 -3.28516328982128 0.00837522062038801 0.0359605690207197 DOWN ENSG00000260105 AOC4P amine oxidase, copper containing 4, pseudogene [Source:HGNC Symbol;Acc:HGNC:48869] - - - - - - 17:42865922-42874369 3 5 3 0 0 1 0.0300998183688759 0.0455916799111073 0.0271310142977268 0 0 0.00940089992592797 0.0342741708592367 0.00313363330864266 3.45121349201069 0.00840577877676487 0.0360813974984239 UP ENSG00000163815 CLEC3B C-type lectin domain family 3 member B [Source:HGNC Symbol;Acc:HGNC:11891] GO:0032502|GO:0031012|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0071704|GO:0043167|GO:0044237|GO:0030246|GO:0043227|GO:0009893|GO:0005615|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0008201|GO:0009888|GO:0007275|GO:0048513|GO:0043168|GO:0031982|GO:0031325|GO:0043231|GO:0043169|GO:0005737|GO:0071559|GO:0019904|GO:0070062|GO:0001503|GO:0019538|GO:0005539|GO:0010033|GO:0031323|GO:0005730|GO:0032268|GO:0010468|GO:0046872|GO:0051604|GO:0031214|GO:0010628|GO:0036143|GO:0071560|GO:0031981|GO:0051247|GO:0070848|GO:0006508|GO:0032270|GO:0044267|GO:0010467|GO:0071310|GO:0051246|GO:0005634|GO:0030282|GO:1903319|GO:0016485|GO:0030162|GO:0045862|GO:0071363|GO:0005509|GO:0001652|GO:0010954|GO:0070613|GO:0031638|GO:0010756|GO:0031639 developmental process|extracellular matrix|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|organic substance metabolic process|ion binding|cellular metabolic process|carbohydrate binding|membrane-bounded organelle|positive regulation of metabolic process|extracellular space|intracellular|protein binding|anatomical structure development|regulation of metabolic process|heparin binding|tissue development|multicellular organism development|animal organ development|anion binding|vesicle|positive regulation of cellular metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|response to transforming growth factor beta|protein domain specific binding|extracellular exosome|ossification|protein metabolic process|glycosaminoglycan binding|response to organic substance|regulation of cellular metabolic process|nucleolus|regulation of cellular protein metabolic process|regulation of gene expression|metal ion binding|protein maturation|biomineral tissue development|positive regulation of gene expression|kringle domain binding|cellular response to transforming growth factor beta stimulus|nuclear lumen|positive regulation of protein metabolic process|response to growth factor|proteolysis|positive regulation of cellular protein metabolic process|cellular protein metabolic process|gene expression|cellular response to organic substance|regulation of protein metabolic process|nucleus|bone mineralization|positive regulation of protein maturation|protein processing|regulation of proteolysis|positive regulation of proteolysis|cellular response to growth factor stimulus|calcium ion binding|granular component|positive regulation of protein processing|regulation of protein processing|zymogen activation|positive regulation of plasminogen activation|plasminogen activation - - - - 3:45001548-45036071 3 5 3 0 0 1 0.128626557162996 0.194828445486798 0.115939867765619 0 0 0.0401731790167988 0.146464956805138 0.0133910596722663 3.45121349201069 0.00841479655075835 0.0361097220391461 UP ENSG00000112116 IL17F interleukin 17F [Source:HGNC Symbol;Acc:HGNC:16404] GO:0032502|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0006807|GO:0051050|GO:0006950|GO:0071704|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0009605|GO:0009893|GO:0009058|GO:0005615|GO:0050793|GO:0005515|GO:0048856|GO:0048646|GO:0019222|GO:0042802|GO:0048514|GO:0060341|GO:0002532|GO:0006725|GO:0009888|GO:0006810|GO:1901360|GO:0001568|GO:0007275|GO:0048513|GO:0005102|GO:0034641|GO:0032940|GO:0006952|GO:0031325|GO:0046483|GO:0042094|GO:0090287|GO:0001817|GO:0042228|GO:0001816|GO:0009611|GO:0042253|GO:0032880|GO:0051222|GO:0071559|GO:0009966|GO:0046983|GO:0045184|GO:0001819|GO:0010646|GO:0006139|GO:0001525|GO:0008104|GO:0007154|GO:0007165|GO:0019955|GO:0042109|GO:0051047|GO:0042226|GO:0044249|GO:0019538|GO:0010033|GO:0031323|GO:0016525|GO:0042107|GO:0010468|GO:0005126|GO:0034645|GO:0051216|GO:0042089|GO:0007166|GO:0032675|GO:0001944|GO:0072358|GO:0032623|GO:0032635|GO:0050727|GO:0051252|GO:0051223|GO:0015031|GO:0005125|GO:0010628|GO:0032755|GO:0071560|GO:0070201|GO:0006954|GO:0050714|GO:0045408|GO:0050715|GO:0051046|GO:0045765|GO:0042035|GO:0009306|GO:0050729|GO:0070848|GO:1900017|GO:0050663|GO:1901342|GO:0045423|GO:0010467|GO:0046903|GO:0071310|GO:1900015|GO:0031328|GO:0051246|GO:0009059|GO:0001501|GO:0061448|GO:0050707|GO:0016070|GO:0072359|GO:0010557|GO:0045414|GO:0045076|GO:0042803|GO:0002534|GO:0032637|GO:0045893|GO:0032774|GO:2001141|GO:0050708|GO:0071363|GO:0007179|GO:0007167|GO:0017015|GO:0006351|GO:2000778|GO:0006355|GO:0045944|GO:0006366|GO:0006357|GO:1903506|GO:0007178 developmental process|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|nitrogen compound metabolic process|positive regulation of transport|response to stress|organic substance metabolic process|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|response to external stimulus|positive regulation of metabolic process|biosynthetic process|extracellular space|regulation of developmental process|protein binding|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|identical protein binding|blood vessel morphogenesis|regulation of cellular localization|production of molecular mediator involved in inflammatory response|cellular aromatic compound metabolic process|tissue development|transport|organic cyclic compound metabolic process|blood vessel development|multicellular organism development|animal organ development|receptor binding|cellular nitrogen compound metabolic process|secretion by cell|defense response|positive regulation of cellular metabolic process|heterocycle metabolic process|interleukin-2 biosynthetic process|regulation of cellular response to growth factor stimulus|regulation of cytokine production|interleukin-8 biosynthetic process|cytokine production|response to wounding|granulocyte macrophage colony-stimulating factor biosynthetic process|regulation of protein localization|positive regulation of protein transport|response to transforming growth factor beta|regulation of signal transduction|protein dimerization activity|establishment of protein localization|positive regulation of cytokine production|regulation of cell communication|nucleobase-containing compound metabolic process|angiogenesis|protein localization|cell communication|signal transduction|cytokine binding|lymphotoxin A biosynthetic process|positive regulation of secretion|interleukin-6 biosynthetic process|cellular biosynthetic process|protein metabolic process|response to organic substance|regulation of cellular metabolic process|negative regulation of angiogenesis|cytokine metabolic process|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|cartilage development|cytokine biosynthetic process|cell surface receptor signaling pathway|regulation of interleukin-6 production|vasculature development|cardiovascular system development|interleukin-2 production|interleukin-6 production|regulation of inflammatory response|regulation of RNA metabolic process|regulation of protein transport|protein transport|cytokine activity|positive regulation of gene expression|positive regulation of interleukin-6 production|cellular response to transforming growth factor beta stimulus|regulation of establishment of protein localization|inflammatory response|positive regulation of protein secretion|regulation of interleukin-6 biosynthetic process|positive regulation of cytokine secretion|regulation of secretion|regulation of angiogenesis|regulation of cytokine biosynthetic process|protein secretion|positive regulation of inflammatory response|response to growth factor|positive regulation of cytokine production involved in inflammatory response|cytokine secretion|regulation of vasculature development|regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|gene expression|secretion|cellular response to organic substance|regulation of cytokine production involved in inflammatory response|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|macromolecule biosynthetic process|skeletal system development|connective tissue development|regulation of cytokine secretion|RNA metabolic process|circulatory system development|positive regulation of macromolecule biosynthetic process|regulation of interleukin-8 biosynthetic process|regulation of interleukin-2 biosynthetic process|protein homodimerization activity|cytokine production involved in inflammatory response|interleukin-8 production|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|regulation of protein secretion|cellular response to growth factor stimulus|transforming growth factor beta receptor signaling pathway|enzyme linked receptor protein signaling pathway|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-templated|positive regulation of interleukin-6 secretion|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transmembrane receptor protein serine/threonine kinase signaling pathway K05494 interleukin 17F[-] hsa05321 Inflammatory bowel disease (IBD) - Homo sapiens (human) 6:52236681-52244537 2 4 2 0 0 0 0.10983472507479 0.199650006456738 0.0990342422309216 0 0 0 0.13617299125415 0 Inf 0.00841628802540599 0.0361109316916456 UP ENSG00000213394 RPSAP46 ribosomal protein SA pseudogene 46 [Source:HGNC Symbol;Acc:HGNC:36082] - - - - - - 7:101203614-101204495 2 4 2 0 0 0 0.160393566775884 0.291552390381268 0.144621433099124 0 0 0 0.198855796752092 0 Inf 0.00841878939275972 0.0361164734202398 UP ENSG00000271021 RP5-878I13.2 - - - - - - - X:115454733-115455194 1 1 3 7 5 10 0.153174661087909 0.139215858737964 0.414070956305783 0.960246556584027 0.628138301350424 1.43490902711598 0.235487158710552 1.00776462835014 -2.09743842912026 0.00847485223688329 0.0363308786157257 DOWN ENSG00000273521 RP11-45A17.4 - - - - - - - 10:131980240-131981337 16 16 14 7 7 7 1.0307862186881 0.936791287126695 0.813199205786875 0.404038168617323 0.370007494575289 0.422650942071428 0.92692557053389 0.398898868421347 1.21643046836806 0.00847784038814449 0.0363384704878199 UP ENSG00000197558 SSPO SCO-spondin [Source:HGNC Symbol;Acc:HGNC:21998] GO:0009987|GO:0008152|GO:0005488|GO:0009892|GO:0048523|GO:0050794|GO:0071704|GO:0044237|GO:0030234|GO:0005515|GO:0019222|GO:0004857|GO:0044092|GO:0050790|GO:0043086|GO:0019538|GO:0031324|GO:0031323|GO:0032268|GO:0030414|GO:0032269|GO:0051346|GO:0006508|GO:0044267|GO:0051246|GO:0010466|GO:0030162|GO:0052547|GO:0045861 cellular process|metabolic process|binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|organic substance metabolic process|cellular metabolic process|enzyme regulator activity|protein binding|regulation of metabolic process|enzyme inhibitor activity|negative regulation of molecular function|regulation of catalytic activity|negative regulation of catalytic activity|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of cellular protein metabolic process|peptidase inhibitor activity|negative regulation of cellular protein metabolic process|negative regulation of hydrolase activity|proteolysis|cellular protein metabolic process|regulation of protein metabolic process|negative regulation of peptidase activity|regulation of proteolysis|regulation of peptidase activity|negative regulation of proteolysis - - - - 7:149776042-149833979 1 0 3 5 3 17 0.00257314716830099 0 0.00695588618330563 0.0115217876491946 0.00633159629860098 0.0409787908123777 0.00317634445053554 0.0196107249200578 -2.62620359100076 0.00848349942526129 0.0363470711598379 DOWN ENSG00000165178 NCF1C neutrophil cytosolic factor 1C pseudogene [Source:HGNC Symbol;Acc:HGNC:32523] - - - - - - 7:75156639-75172044 12 7 4 1 2 3 0.594862660355206 0.315375991038091 0.178775198308938 0.0443929877370792 0.0813373047090201 0.139353353982589 0.363004616567412 0.0883612154762294 2.0385027267171 0.00848601364383073 0.036352626104595 UP ENSG00000184702 SEPT5 septin 5 [Source:HGNC Symbol;Acc:HGNC:9164] GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0003824|GO:0036094|GO:0042995|GO:0008021|GO:0097159|GO:0050794|GO:0043229|GO:0051050|GO:0016079|GO:0043167|GO:0051641|GO:0023051|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0012505|GO:0016080|GO:0060341|GO:0007049|GO:0050804|GO:0051640|GO:0006810|GO:0022402|GO:0043195|GO:0005938|GO:0060627|GO:0043168|GO:0032940|GO:0001882|GO:0031982|GO:0016817|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0006903|GO:0051656|GO:0043005|GO:0010646|GO:0000149|GO:0007154|GO:0051649|GO:0044306|GO:0001505|GO:2000300|GO:0051047|GO:0000166|GO:0051301|GO:0046928|GO:0016192|GO:0006836|GO:0051650|GO:0035639|GO:0030424|GO:0031410|GO:0032386|GO:0001883|GO:0048489|GO:0045921|GO:0016023|GO:0006887|GO:0016818|GO:0070382|GO:0046907|GO:0032549|GO:0043679|GO:0017157|GO:1902803|GO:0051046|GO:0031988|GO:0046903|GO:0017076|GO:0051648|GO:0019905|GO:0005856|GO:0000910|GO:0032561|GO:0045055|GO:0016482|GO:1903305|GO:0005525|GO:0019001|GO:0016462|GO:0017111|GO:0017156|GO:0017158|GO:0007268|GO:0003924 synapse|structural molecule activity|signaling|cell|membrane|cellular process|binding|catalytic activity|small molecule binding|cell projection|synaptic vesicle|organic cyclic compound binding|regulation of cellular process|intracellular organelle|positive regulation of transport|synaptic vesicle exocytosis|ion binding|cellular localization|regulation of signaling|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|neurotransmitter secretion|protein binding|plasma membrane|endomembrane system|synaptic vesicle targeting|regulation of cellular localization|cell cycle|modulation of synaptic transmission|organelle localization|transport|cell cycle process|terminal bouton|cell cortex|regulation of vesicle-mediated transport|anion binding|secretion by cell|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|vesicle targeting|establishment of organelle localization|neuron projection|regulation of cell communication|SNARE binding|cell communication|establishment of localization in cell|neuron projection terminus|regulation of neurotransmitter levels|regulation of synaptic vesicle exocytosis|positive regulation of secretion|nucleotide binding|cell division|regulation of neurotransmitter secretion|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|purine ribonucleoside triphosphate binding|axon|cytoplasmic vesicle|regulation of intracellular transport|purine nucleoside binding|synaptic vesicle transport|positive regulation of exocytosis|cytoplasmic, membrane-bounded vesicle|exocytosis|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|exocytic vesicle|intracellular transport|ribonucleoside binding|axon terminus|regulation of exocytosis|regulation of synaptic vesicle transport|regulation of secretion|membrane-bounded vesicle|secretion|purine nucleotide binding|vesicle localization|syntaxin binding|cytoskeleton|cytokinesis|guanyl ribonucleotide binding|regulated exocytosis|cytosolic transport|regulation of regulated secretory pathway|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|nucleoside-triphosphatase activity|calcium ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|synaptic transmission|GTPase activity K04557 septin 5[-] hsa05012 Parkinson,s disease - Homo sapiens (human) 22:19714464-19724772 14 30 45 53 58 86 0.0752535062479642 0.146551600484201 0.218078435966679 0.255249924836183 0.25579135001285 0.433227908053782 0.146627847566281 0.314756394300938 -1.10207656051562 0.00848975678337094 0.0363606392590052 DOWN ENSG00000264083 RP11-227G15.9 - - - - - - - 17:32430967-32432841 5 4 0 0 0 0 0.628243241945425 0.456748149762483 0 0 0 0 0.361663797235969 0 Inf 0.00849916337214124 0.0363932907791028 UP ENSG00000173728 C1orf100 chromosome 1 open reading frame 100 [Source:HGNC Symbol;Acc:HGNC:30435] - - - - - - 1:244352635-244389663 8 8 3 1 3 0 0.357465889820165 0.324888450178494 0.120846987879515 0.0400181891982388 0.110000986357627 0 0.267733775959391 0.0500063918519553 2.42061473560429 0.00853332324669835 0.0365133771258324 UP ENSG00000269014 CTB-147N14.4 - - - - - - - 19:46826895-46828440 5 2 1 0 0 0 1.24542586343406 0.452727479430067 0.224453090914945 0 0 0 0.640868811259691 0 Inf 0.00855040450227888 0.0365759816608445 UP ENSG00000142973 CYP4B1 cytochrome P450 family 4 subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:2644] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0015643|GO:0097159|GO:0016491|GO:0043229|GO:0042175|GO:0071704|GO:0009056|GO:0043167|GO:0008144|GO:0044237|GO:0043227|GO:0019825|GO:0031224|GO:0005622|GO:0005789|GO:0012505|GO:0031090|GO:0006725|GO:1901360|GO:0009410|GO:0044281|GO:0043231|GO:0043169|GO:0005737|GO:0016705|GO:0042493|GO:0004497|GO:0005783|GO:0006805|GO:0017144|GO:0016021|GO:0055114|GO:0042737|GO:0046872|GO:0020037|GO:0042738|GO:0018585|GO:0018917|GO:0071466|GO:0016712|GO:0070330|GO:0018879|GO:0046914|GO:0005506 cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|toxic substance binding|organic cyclic compound binding|oxidoreductase activity|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|catabolic process|ion binding|drug binding|cellular metabolic process|membrane-bounded organelle|oxygen binding|intrinsic component of membrane|intracellular|endoplasmic reticulum membrane|endomembrane system|organelle membrane|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|response to xenobiotic stimulus|small molecule metabolic process|intracellular membrane-bounded organelle|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|response to drug|monooxygenase activity|endoplasmic reticulum|xenobiotic metabolic process|drug metabolic process|integral component of membrane|oxidation-reduction process|drug catabolic process|metal ion binding|heme binding|exogenous drug catabolic process|fluorene oxygenase activity|fluorene metabolic process|cellular response to xenobiotic stimulus|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|aromatase activity|biphenyl metabolic process|transition metal ion binding|iron ion binding - - - - 1:46757838-46819413 1 3 4 6 9 14 0.010320357798252 0.0281307176454832 0.0372046387613904 0.0554594014351769 0.0761756690773573 0.135356784131378 0.0252185714017085 0.0889972848813041 -1.81927477194062 0.00857678885141921 0.0366783346755865 DOWN ENSG00000105141 CASP14 caspase 14 [Source:HGNC Symbol;Acc:HGNC:1502] GO:0032502|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:1903561|GO:0043229|GO:0071704|GO:0043227|GO:0016787|GO:0005622|GO:0005515|GO:0048856|GO:0009888|GO:0007275|GO:0048513|GO:0031982|GO:0005882|GO:0043231|GO:0008233|GO:0005737|GO:0031424|GO:0070062|GO:0008219|GO:0048869|GO:0019538|GO:0070268|GO:0006508|GO:0043588|GO:0045095|GO:0012501|GO:0060429|GO:0030154|GO:0005856|GO:0005634|GO:0030855|GO:0030216|GO:0008544|GO:0004175|GO:0045111|GO:0008234|GO:0006915|GO:0004197|GO:0009913|GO:0097153 developmental process|cell|cellular process|extracellular region|metabolic process|binding|catalytic activity|extracellular vesicle|intracellular organelle|organic substance metabolic process|membrane-bounded organelle|hydrolase activity|intracellular|protein binding|anatomical structure development|tissue development|multicellular organism development|animal organ development|vesicle|intermediate filament|intracellular membrane-bounded organelle|peptidase activity|cytoplasm|keratinization|extracellular exosome|cell death|cellular developmental process|protein metabolic process|cornification|proteolysis|skin development|keratin filament|programmed cell death|epithelium development|cell differentiation|cytoskeleton|nucleus|epithelial cell differentiation|keratinocyte differentiation|epidermis development|endopeptidase activity|intermediate filament cytoskeleton|cysteine-type peptidase activity|apoptotic process|cysteine-type endopeptidase activity|epidermal cell differentiation|cysteine-type endopeptidase activity involved in apoptotic process - - - - 19:15049384-15058293 1 0 3 4 5 13 0.0181081610600343 0 0.0489510700648085 0.0648729299967602 0.0742579056355926 0.220536264946555 0.0223530770416143 0.119889033526303 -2.4231543525431 0.00859139114075533 0.0367302579286996 DOWN ENSG00000271862 RP11-343L5.2 - - - - - - - 5:83049376-83050964 42 35 25 13 12 26 1.86969299290165 1.41603901663015 1.00340964489677 0.518514175445455 0.438305930942456 1.08473312150527 1.42971388480952 0.68051774263106 1.07102178125838 0.00859364191941358 0.0367346199688106 UP ENSG00000177725 CTD-2530N21.5 - - - - - - - 8:22169338-22171710 0 1 1 3 8 4 0 0.0135720039537749 0.0134510820468125 0.0401161634763624 0.0979808939919856 0.0559491414878397 0.00900769533352913 0.0646820663187292 -2.84413583034766 0.00860160597975217 0.0367613530878481 DOWN ENSG00000260494 AC002310.10 - - - - - - - 16:30537202-30538231 4 6 7 1 2 1 0.391333681594274 0.533504581569041 0.617445352420644 0.0876193547729074 0.160537114550168 0.0916815288765119 0.514094538527986 0.113279332733196 2.18214901330218 0.00860235856741834 0.0367613530878481 UP ENSG00000143469 SYT14 synaptotagmin 14 [Source:HGNC Symbol;Acc:HGNC:23143] GO:0016020|GO:0005488|GO:0043167|GO:0031224|GO:0005515|GO:0030276|GO:0043169|GO:0000149|GO:0016021|GO:0046872|GO:0019905|GO:0005509 membrane|binding|ion binding|intrinsic component of membrane|protein binding|clathrin binding|cation binding|SNARE binding|integral component of membrane|metal ion binding|syntaxin binding|calcium ion binding - - - - 1:209938174-210171315 0 0 0 6 4 0 0 0 0 0.0143965593655502 0.00878806237514834 0 0 0.00772820724689951 -Inf 0.00861218590081217 0.0367980818495558 DOWN ENSG00000213277 MARCKSL1P1 MARCKS-like 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:45239] - - - - - - 10:103175554-103176094 1 1 3 6 11 5 0.130807196714628 0.118886740733714 0.3536058813554 0.702929973458426 1.18004601974715 0.612752760885383 0.201099939601247 0.831909584696986 -2.04851409060486 0.00861491461163466 0.0368044734996768 DOWN ENSG00000175161 CADM2 cell adhesion molecule 2 [Source:HGNC Symbol;Acc:HGNC:29849] GO:0045202|GO:0005623|GO:0016020|GO:0009987|GO:0030054|GO:0005488|GO:0042995|GO:0004872|GO:0005911|GO:0016043|GO:0007155|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0042802|GO:0005102|GO:0005912|GO:0022607|GO:0098609|GO:0005887|GO:0043005|GO:0046983|GO:0050839|GO:0008037|GO:0031226|GO:0005913|GO:0016021|GO:0098742|GO:0045216|GO:0030424|GO:0034329|GO:0042803|GO:0007157|GO:0034332|GO:0007156 synapse|cell|membrane|cellular process|cell junction|binding|cell projection|receptor activity|cell-cell junction|cellular component organization|cell adhesion|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|identical protein binding|receptor binding|adherens junction|cellular component assembly|cell-cell adhesion|integral component of plasma membrane|neuron projection|protein dimerization activity|cell adhesion molecule binding|cell recognition|intrinsic component of plasma membrane|cell-cell adherens junction|integral component of membrane|cell-cell adhesion via plasma-membrane adhesion molecules|cell-cell junction organization|axon|cell junction assembly|protein homodimerization activity|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|adherens junction organization|homophilic cell adhesion via plasma membrane adhesion molecules - - - - 3:84958981-86074429 0 0 7 7 10 14 0 0 0.0383351644310971 0.0380965143101606 0.0498411155386682 0.0797030029015764 0.012778388143699 0.0558802109168017 -2.12863159884077 0.00863407384367111 0.0368757711772471 DOWN ENSG00000095585 BLNK B-cell linker [Source:HGNC Symbol;Acc:HGNC:14211] GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0060090|GO:0051716|GO:0050794|GO:0045321|GO:0006950|GO:0006955|GO:0023051|GO:0005068|GO:0071944|GO:0005622|GO:0002520|GO:0005515|GO:0005886|GO:0048856|GO:0035591|GO:0006959|GO:0007275|GO:0048513|GO:0005102|GO:0006952|GO:0019899|GO:0005737|GO:0001775|GO:0009966|GO:0030674|GO:0010646|GO:0046649|GO:0007154|GO:0007165|GO:0048869|GO:0009967|GO:0005829|GO:0042113|GO:0007166|GO:0030097|GO:0030098|GO:0030971|GO:0006954|GO:0019900|GO:0035556|GO:0030154|GO:0005070|GO:0002521|GO:0030183|GO:0007167|GO:0019901|GO:1990782|GO:0007169 developmental process|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|binding, bridging|cellular response to stimulus|regulation of cellular process|leukocyte activation|response to stress|immune response|regulation of signaling|transmembrane receptor protein tyrosine kinase adaptor activity|cell periphery|intracellular|immune system development|protein binding|plasma membrane|anatomical structure development|signaling adaptor activity|humoral immune response|multicellular organism development|animal organ development|receptor binding|defense response|enzyme binding|cytoplasm|cell activation|regulation of signal transduction|protein binding, bridging|regulation of cell communication|lymphocyte activation|cell communication|signal transduction|cellular developmental process|positive regulation of signal transduction|cytosol|B cell activation|cell surface receptor signaling pathway|hemopoiesis|lymphocyte differentiation|receptor tyrosine kinase binding|inflammatory response|kinase binding|intracellular signal transduction|cell differentiation|SH3/SH2 adaptor activity|leukocyte differentiation|B cell differentiation|enzyme linked receptor protein signaling pathway|protein kinase binding|protein tyrosine kinase binding|transmembrane receptor protein tyrosine kinase signaling pathway K07371 B-cell linker protein[-] hsa04380|hsa04064|hsa04662|hsa05340 Osteoclast differentiation - Homo sapiens (human)|NF-kappa B signaling pathway - Homo sapiens (human)|B cell receptor signaling pathway - Homo sapiens (human)|Primary immunodeficiency - Homo sapiens (human) 10:96191702-96271587 2 2 2 7 6 14 0.0281358643389678 0.0255717192040849 0.0253691535388677 0.0882326788269332 0.0692531824700308 0.184594564198261 0.0263589123606401 0.114026808498408 -2.11301030471759 0.00864360828156664 0.0369059327285312 DOWN ENSG00000259224 SLC35G6 solute carrier family 35 member G6 [Source:HGNC Symbol;Acc:HGNC:31351] GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 17:7481332-7483496 8 9 5 1 3 3 0.333452270822228 0.340964138697404 0.187894452449439 0.0373298724223995 0.102611409195123 0.117181635906396 0.28743695398969 0.0857076391746395 1.74574984861063 0.0086706070432087 0.0370053327616801 UP ENSG00000167281 RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 [Source:HGNC Symbol;Acc:HGNC:27097] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0044297|GO:0043227|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:0043025|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0043204|GO:0036477|GO:0006139|GO:0000166|GO:0031323|GO:0003677|GO:0010468|GO:0003723|GO:0051252|GO:0010467|GO:0016070|GO:0005634|GO:0006396|GO:0050684|GO:0043484|GO:0016071|GO:0044822|GO:0003729|GO:0048024|GO:0006397|GO:0008380|GO:0000375|GO:0000381|GO:0000398|GO:0000380 cell|cellular process|metabolic process|binding|small molecule binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cell body|membrane-bounded organelle|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|neuronal cell body|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|perikaryon|somatodendritic compartment|nucleobase-containing compound metabolic process|nucleotide binding|regulation of cellular metabolic process|DNA binding|regulation of gene expression|RNA binding|regulation of RNA metabolic process|gene expression|RNA metabolic process|nucleus|RNA processing|regulation of mRNA processing|regulation of RNA splicing|mRNA metabolic process|poly(A) RNA binding|mRNA binding|regulation of mRNA splicing, via spliceosome|mRNA processing|RNA splicing|RNA splicing, via transesterification reactions|regulation of alternative mRNA splicing, via spliceosome|mRNA splicing, via spliceosome|alternative mRNA splicing, via spliceosome - - - - 17:79089345-79516148 10 9 19 5 6 4 0.0601015914250702 0.0491644271704899 0.102961136354889 0.0269243099607571 0.0295866260055497 0.0225289303688395 0.070742384983483 0.0263466221117154 1.42495685191158 0.00867620371294906 0.0370133446193743 UP ENSG00000243902 ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 [Source:EntrezGene;Acc:114794] - - - - - - 22:37339583-37427445 6 6 10 28 16 16 0.173650318203351 0.157824800521447 0.260957659561021 0.726104645981721 0.379952860845788 0.434006939257076 0.19747759276194 0.513354815361528 -1.37826735393233 0.00867489523560234 0.0370133446193743 DOWN ENSG00000179869 ABCA13 ATP binding cassette subfamily A member 13 [Source:HGNC Symbol;Acc:HGNC:14638] GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0003824|GO:0036094|GO:0097159|GO:0022857|GO:0043229|GO:0043167|GO:0043227|GO:0016787|GO:0031224|GO:0005622|GO:0006810|GO:0043168|GO:0001882|GO:0016817|GO:0043231|GO:0055085|GO:0000166|GO:0016021|GO:0010876|GO:0016820|GO:0035639|GO:0001883|GO:0016818|GO:0006811|GO:0032549|GO:0006869|GO:0017076|GO:0015914|GO:0006820|GO:0015711|GO:0005524|GO:0030554|GO:0015918|GO:0042626|GO:0016462|GO:0017111|GO:0030301|GO:0033700|GO:0016887|GO:0033344|GO:0042623|GO:0043492 transporter activity|cell|membrane|cellular process|metabolic process|binding|catalytic activity|small molecule binding|organic cyclic compound binding|transmembrane transporter activity|intracellular organelle|ion binding|membrane-bounded organelle|hydrolase activity|intrinsic component of membrane|intracellular|transport|anion binding|nucleoside binding|hydrolase activity, acting on acid anhydrides|intracellular membrane-bounded organelle|transmembrane transport|nucleotide binding|integral component of membrane|lipid localization|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances|purine ribonucleoside triphosphate binding|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ion transport|ribonucleoside binding|lipid transport|purine nucleotide binding|phospholipid transport|anion transport|organic anion transport|ATP binding|adenyl nucleotide binding|sterol transport|ATPase activity, coupled to transmembrane movement of substances|pyrophosphatase activity|nucleoside-triphosphatase activity|cholesterol transport|phospholipid efflux|ATPase activity|cholesterol efflux|ATPase activity, coupled|ATPase activity, coupled to movement of substances K05647 ATP binding cassette, subfamily A (ABC1), member 13[-] hsa02010 ABC transporters - Homo sapiens (human) 7:48171458-48647496 2 0 2 7 4 9 0.00565077395231996 0 0.00509511100433102 0.0177205475990342 0.00927248522626496 0.0238323237527407 0.00358196165221699 0.0169417855260133 -2.24176413366596 0.00870164041937457 0.0371059524467945 DOWN ENSG00000106624 AEBP1 AE binding protein 1 [Source:HGNC Symbol;Acc:HGNC:303] GO:0032502|GO:0031012|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0001071|GO:0005488|GO:0000988|GO:0003824|GO:1903561|GO:0097159|GO:0009892|GO:0003700|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0043227|GO:0016787|GO:0009058|GO:0005615|GO:0005622|GO:0005515|GO:0048856|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0031982|GO:0046483|GO:0061061|GO:0043231|GO:0043169|GO:0008233|GO:0005737|GO:0000981|GO:0009890|GO:0006139|GO:0005516|GO:0070062|GO:0044249|GO:0019538|GO:0031324|GO:0031323|GO:0017171|GO:0003677|GO:0010468|GO:0034645|GO:0003714|GO:0006518|GO:0046872|GO:0010629|GO:0051252|GO:0051604|GO:0006508|GO:0008236|GO:0043603|GO:0010467|GO:0001227|GO:0009059|GO:0001501|GO:0007517|GO:0016070|GO:0005634|GO:0008237|GO:0000975|GO:0016485|GO:0045892|GO:0032774|GO:0043565|GO:2001141|GO:1902679|GO:0003690|GO:0008238|GO:0046914|GO:0006351|GO:0070008|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0044212|GO:0004180|GO:0004185|GO:0008235|GO:0000122|GO:0008270|GO:0000976|GO:0001012|GO:0004181|GO:0000977 developmental process|extracellular matrix|cell|cellular process|extracellular region|metabolic process|nucleic acid binding transcription factor activity|binding|transcription factor activity, protein binding|catalytic activity|extracellular vesicle|organic cyclic compound binding|negative regulation of metabolic process|transcription factor activity, sequence-specific DNA binding|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|hydrolase activity|biosynthetic process|extracellular space|intracellular|protein binding|anatomical structure development|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|vesicle|heterocycle metabolic process|muscle structure development|intracellular membrane-bounded organelle|cation binding|peptidase activity|cytoplasm|RNA polymerase II transcription factor activity, sequence-specific DNA binding|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|calmodulin binding|extracellular exosome|cellular biosynthetic process|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|serine hydrolase activity|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|transcription corepressor activity|peptide metabolic process|metal ion binding|negative regulation of gene expression|regulation of RNA metabolic process|protein maturation|proteolysis|serine-type peptidase activity|cellular amide metabolic process|gene expression|transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding|macromolecule biosynthetic process|skeletal system development|muscle organ development|RNA metabolic process|nucleus|metallopeptidase activity|regulatory region DNA binding|protein processing|negative regulation of transcription, DNA-templated|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|double-stranded DNA binding|exopeptidase activity|transition metal ion binding|transcription, DNA-templated|serine-type exopeptidase activity|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|carboxypeptidase activity|serine-type carboxypeptidase activity|metalloexopeptidase activity|negative regulation of transcription from RNA polymerase II promoter|zinc ion binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|metallocarboxypeptidase activity|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 7:44104361-44114562 5 1 6 1 0 0 0.0380651038759443 0.00692183886536153 0.0411825561752347 0.0068175627960409 0 0 0.0287231663055135 0.00227252093201363 3.65984930563548 0.0087220279820467 0.0371769593626531 UP ENSG00000204539 CDSN corneodesmosin [Source:HGNC Symbol;Acc:HGNC:1802] GO:0032502|GO:0009653|GO:0048856|GO:0007275|GO:0048513|GO:0009887|GO:0043589|GO:0043588 developmental process|anatomical structure morphogenesis|anatomical structure development|multicellular organism development|animal organ development|organ morphogenesis|skin morphogenesis|skin development - - - - 6:31115090-31120446 1 2 1 15 0 13 0.0277298955417766 0.0503818981810889 0.0249783220297196 0.372523797020571 0 0.337717759957343 0.0343633719175284 0.236747185659305 -2.78440376223095 0.00873421014499321 0.0372202467018354 DOWN ENSG00000107731 UNC5B unc-5 netrin receptor B [Source:HGNC Symbol;Acc:HGNC:12568] GO:0040011|GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0048523|GO:0050794|GO:0023051|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0023057|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0048514|GO:0006935|GO:0048468|GO:0001568|GO:0010941|GO:0007275|GO:0006928|GO:0009966|GO:0060548|GO:0010646|GO:0001525|GO:0007154|GO:0007165|GO:0009968|GO:0008219|GO:0030030|GO:0048869|GO:0016021|GO:0009967|GO:0098857|GO:1902533|GO:0000902|GO:0031175|GO:1901215|GO:0007166|GO:0001944|GO:0072358|GO:0043069|GO:2001234|GO:0070997|GO:0000904|GO:1901214|GO:0012501|GO:0035556|GO:0032990|GO:0007399|GO:0097485|GO:0030154|GO:0048858|GO:0045121|GO:1902531|GO:0072359|GO:0043067|GO:0097190|GO:0048666|GO:0030182|GO:2001237|GO:0007411|GO:0043523|GO:0014068|GO:2001240|GO:0097192|GO:2001236|GO:0061564|GO:0048017|GO:0042981|GO:0043066|GO:0051402|GO:0014066|GO:0043524|GO:0022008|GO:0048667|GO:0048812|GO:0097191|GO:0006915|GO:0048015|GO:0007409|GO:0048699|GO:2001239|GO:0033564|GO:0014065 locomotion|developmental process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of cellular process|regulation of cellular process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|negative regulation of signaling|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|blood vessel morphogenesis|chemotaxis|cell development|blood vessel development|regulation of cell death|multicellular organism development|movement of cell or subcellular component|regulation of signal transduction|negative regulation of cell death|regulation of cell communication|angiogenesis|cell communication|signal transduction|negative regulation of signal transduction|cell death|cell projection organization|cellular developmental process|integral component of membrane|positive regulation of signal transduction|membrane microdomain|positive regulation of intracellular signal transduction|cell morphogenesis|neuron projection development|negative regulation of neuron death|cell surface receptor signaling pathway|vasculature development|cardiovascular system development|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|neuron death|cell morphogenesis involved in differentiation|regulation of neuron death|programmed cell death|intracellular signal transduction|cell part morphogenesis|nervous system development|neuron projection guidance|cell differentiation|cell projection morphogenesis|membrane raft|regulation of intracellular signal transduction|circulatory system development|regulation of programmed cell death|apoptotic signaling pathway|neuron development|neuron differentiation|negative regulation of extrinsic apoptotic signaling pathway|axon guidance|regulation of neuron apoptotic process|positive regulation of phosphatidylinositol 3-kinase signaling|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|extrinsic apoptotic signaling pathway in absence of ligand|regulation of extrinsic apoptotic signaling pathway|axon development|inositol lipid-mediated signaling|regulation of apoptotic process|negative regulation of apoptotic process|neuron apoptotic process|regulation of phosphatidylinositol 3-kinase signaling|negative regulation of neuron apoptotic process|neurogenesis|cell morphogenesis involved in neuron differentiation|neuron projection morphogenesis|extrinsic apoptotic signaling pathway|apoptotic process|phosphatidylinositol-mediated signaling|axonogenesis|generation of neurons|regulation of extrinsic apoptotic signaling pathway in absence of ligand|anterior/posterior axon guidance|phosphatidylinositol 3-kinase signaling K07521 netrin receptor unc-5[-] hsa04360 Axon guidance - Homo sapiens (human) 10:71212570-71302864 83 98 326 300 285 601 0.841264350045528 0.902730420368077 2.9790959971484 2.72440386873907 2.3700918377449 5.70894679198841 1.57436358918733 3.60114749949079 -1.19368793161699 0.0087784865846697 0.0373695905459474 DOWN ENSG00000271011 RP11-171I2.5 - - - - - - - 2:178577103-178577622 0 6 2 7 13 11 0 0.741776562450802 0.24530019998736 0.853142132965039 1.45091005865958 1.40233406904866 0.329025587479387 1.23546208689109 -1.90877905065461 0.00878536278941362 0.0373881996742914 DOWN ENSG00000180061 TMEM150B transmembrane protein 150B [Source:HGNC Symbol;Acc:HGNC:34415] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050794|GO:0043229|GO:0009056|GO:0044237|GO:0006914|GO:0043227|GO:0031224|GO:0005622|GO:0019222|GO:0010506|GO:0043231|GO:0005737|GO:0016021|GO:0031323|GO:0005773|GO:0000323|GO:0005764 cell|membrane|cellular process|metabolic process|regulation of cellular process|intracellular organelle|catabolic process|cellular metabolic process|autophagy|membrane-bounded organelle|intrinsic component of membrane|intracellular|regulation of metabolic process|regulation of autophagy|intracellular membrane-bounded organelle|cytoplasm|integral component of membrane|regulation of cellular metabolic process|vacuole|lytic vacuole|lysosome - - - - 19:55312801-55334048 3 3 8 1 1 0 0.0767295080690325 0.0697369236786256 0.184462912499533 0.022902672993786 0.0209917670225425 0 0.11030978141573 0.0146314800054428 2.91441310995256 0.00879070866413089 0.0374056180813802 UP ENSG00000100206 DMC1 DNA meiotic recombinase 1 [Source:HGNC Symbol;Acc:HGNC:2927] GO:0032502|GO:0000003|GO:0005623|GO:0048511|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0043229|GO:0006807|GO:0006950|GO:0000150|GO:0044702|GO:0051321|GO:0071704|GO:0043167|GO:0009628|GO:0042698|GO:0019953|GO:0044237|GO:0003006|GO:0016043|GO:0043227|GO:0032504|GO:0016787|GO:0005622|GO:0022602|GO:0005515|GO:0048856|GO:0048609|GO:0045137|GO:0007049|GO:0007131|GO:0006281|GO:0001556|GO:0006725|GO:0048468|GO:0009314|GO:0009994|GO:0022402|GO:1901360|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0043168|GO:0016788|GO:0001882|GO:0046483|GO:0033554|GO:0016817|GO:0022607|GO:0043231|GO:0048608|GO:0001541|GO:0048515|GO:0007548|GO:0070192|GO:0006139|GO:0008406|GO:0007276|GO:0007126|GO:0007059|GO:0000166|GO:0048869|GO:0007281|GO:0006996|GO:0051276|GO:0003677|GO:0007286|GO:0048232|GO:0000725|GO:0035639|GO:0008585|GO:0061458|GO:0001883|GO:0007129|GO:0048477|GO:0046545|GO:0006302|GO:0016818|GO:0032549|GO:0007140|GO:0007127|GO:0031981|GO:0004518|GO:0045132|GO:0005654|GO:0006259|GO:0005694|GO:0000228|GO:0010212|GO:0017076|GO:0030154|GO:0048599|GO:0048469|GO:0007292|GO:0005634|GO:0006974|GO:0007283|GO:0000724|GO:0042148|GO:0000781|GO:0004536|GO:0034622|GO:0043566|GO:0003697|GO:0000793|GO:0005524|GO:0030554|GO:0003690|GO:0000794|GO:0045143|GO:0065004|GO:0006310|GO:0004519|GO:0016462|GO:0007141|GO:0004520|GO:0000730|GO:0045003|GO:0017111|GO:0006312|GO:0016887|GO:0000400|GO:0042623|GO:0008094 developmental process|reproduction|cell|rhythmic process|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|intracellular organelle|nitrogen compound metabolic process|response to stress|recombinase activity|single organism reproductive process|meiotic cell cycle|organic substance metabolic process|ion binding|response to abiotic stimulus|ovulation cycle|sexual reproduction|cellular metabolic process|developmental process involved in reproduction|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|hydrolase activity|intracellular|ovulation cycle process|protein binding|anatomical structure development|multicellular organismal reproductive process|development of primary sexual characteristics|cell cycle|reciprocal meiotic recombination|DNA repair|oocyte maturation|cellular aromatic compound metabolic process|cell development|response to radiation|oocyte differentiation|cell cycle process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|nucleoside binding|heterocycle metabolic process|cellular response to stress|hydrolase activity, acting on acid anhydrides|cellular component assembly|intracellular membrane-bounded organelle|reproductive structure development|ovarian follicle development|spermatid differentiation|sex differentiation|chromosome organization involved in meiotic cell cycle|nucleobase-containing compound metabolic process|gonad development|gamete generation|meiotic nuclear division|chromosome segregation|nucleotide binding|cellular developmental process|germ cell development|organelle organization|chromosome organization|DNA binding|spermatid development|male gamete generation|recombinational repair|purine ribonucleoside triphosphate binding|female gonad development|reproductive system development|purine nucleoside binding|synapsis|oogenesis|development of primary female sexual characteristics|double-strand break repair|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|ribonucleoside binding|male meiosis|meiosis I|nuclear lumen|nuclease activity|meiotic chromosome segregation|nucleoplasm|DNA metabolic process|chromosome|nuclear chromosome|response to ionizing radiation|purine nucleotide binding|cell differentiation|oocyte development|cell maturation|female gamete generation|nucleus|cellular response to DNA damage stimulus|spermatogenesis|double-strand break repair via homologous recombination|strand invasion|chromosome, telomeric region|deoxyribonuclease activity|cellular macromolecular complex assembly|structure-specific DNA binding|single-stranded DNA binding|condensed chromosome|ATP binding|adenyl nucleotide binding|double-stranded DNA binding|condensed nuclear chromosome|homologous chromosome segregation|protein-DNA complex assembly|DNA recombination|endonuclease activity|pyrophosphatase activity|male meiosis I|endodeoxyribonuclease activity|DNA recombinase assembly|double-strand break repair via synthesis-dependent strand annealing|nucleoside-triphosphatase activity|mitotic recombination|ATPase activity|four-way junction DNA binding|ATPase activity, coupled|DNA-dependent ATPase activity - - - - 22:38518949-38570286 4 3 12 19 14 22 0.0615074460418827 0.0419331154119735 0.166377526947948 0.261783508787791 0.176638360453768 0.317064771426305 0.0899393628006014 0.251828880222621 -1.4854191756019 0.00882095252473284 0.0375236130911049 DOWN ENSG00000249568 RP11-234O6.2 - - - - - - - 4:161378953-161388417 0 0 1 3 8 2 0 0 0.0224453090914945 0.0669403164487611 0.16349699177043 0.0466801023786747 0.00748176969716483 0.0923724701992886 -3.62601148593637 0.00885814513261814 0.0376710918503108 DOWN ENSG00000234857 HNRNPUL2-BSCL2 HNRNPUL2-BSCL2 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:49189] GO:0005488|GO:0005515 binding|protein binding - - - - 11:62690275-62727384 951 711 596 146 0 296 16.8134880676775 11.4242194958451 9.50030436509252 2.31274278668774 0 4.90453604550578 12.5793373095384 2.40575961073117 2.38649152450529 0.00886186687555072 0.0376815515884762 UP ENSG00000236670 KRT18P5 keratin 18 pseudogene 5 [Source:HGNC Symbol;Acc:HGNC:19259] - - - - - - 22:20482815-20484105 14 14 22 9 10 4 0.767107778639201 0.697151223165742 1.08679348998757 0.441824643187831 0.449573811346082 0.205377987227632 0.850350830597504 0.365592147253848 1.21782309673829 0.00887690331247775 0.0377401127158517 UP ENSG00000188687 SLC4A5 solute carrier family 4 (sodium bicarbonate cotransporter), member 5 [Source:HGNC Symbol;Acc:HGNC:18168] GO:0032502|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0022857|GO:0071704|GO:0051641|GO:0045177|GO:0016043|GO:0071944|GO:0031224|GO:0005886|GO:0048856|GO:0019222|GO:0003014|GO:0060041|GO:0051640|GO:0009888|GO:0048468|GO:0006810|GO:0016324|GO:0007275|GO:0048513|GO:0007423|GO:0022891|GO:0055085|GO:0008217|GO:0048869|GO:0016021|GO:0050878|GO:0003013|GO:0006996|GO:0051646|GO:0010468|GO:0001654|GO:0007589|GO:0007005|GO:0002064|GO:0006811|GO:0015075|GO:0060429|GO:0010467|GO:0033326|GO:0046903|GO:0030154|GO:0008015|GO:0048311|GO:0003073|GO:0034220|GO:0098655|GO:0006820|GO:0015711|GO:0098656|GO:0030855|GO:0043010|GO:0015293|GO:0015297|GO:0008509|GO:0006812|GO:0008324|GO:0015301|GO:0008510|GO:0022890|GO:0030001|GO:0008514|GO:0015701|GO:0015672|GO:0015106|GO:0035725|GO:0006814|GO:0015077|GO:0005452|GO:0046873|GO:0015081 developmental process|transporter activity|cell|membrane|cellular process|metabolic process|transmembrane transporter activity|organic substance metabolic process|cellular localization|apical part of cell|cellular component organization|cell periphery|intrinsic component of membrane|plasma membrane|anatomical structure development|regulation of metabolic process|renal system process|retina development in camera-type eye|organelle localization|tissue development|cell development|transport|apical plasma membrane|multicellular organism development|animal organ development|sensory organ development|substrate-specific transmembrane transporter activity|transmembrane transport|regulation of blood pressure|cellular developmental process|integral component of membrane|regulation of body fluid levels|circulatory system process|organelle organization|mitochondrion localization|regulation of gene expression|eye development|body fluid secretion|mitochondrion organization|epithelial cell development|ion transport|ion transmembrane transporter activity|epithelium development|gene expression|cerebrospinal fluid secretion|secretion|cell differentiation|blood circulation|mitochondrion distribution|regulation of systemic arterial blood pressure|ion transmembrane transport|cation transmembrane transport|anion transport|organic anion transport|anion transmembrane transport|epithelial cell differentiation|camera-type eye development|symporter activity|antiporter activity|anion transmembrane transporter activity|cation transport|cation transmembrane transporter activity|anion:anion antiporter activity|sodium:bicarbonate symporter activity|inorganic cation transmembrane transporter activity|metal ion transport|organic anion transmembrane transporter activity|bicarbonate transport|monovalent inorganic cation transport|bicarbonate transmembrane transporter activity|sodium ion transmembrane transport|sodium ion transport|monovalent inorganic cation transmembrane transporter activity|inorganic anion exchanger activity|metal ion transmembrane transporter activity|sodium ion transmembrane transporter activity K13857 solute carrier family 4 (sodium bicarbonate cotransporter), member 5[-] hsa04976 Bile secretion - Homo sapiens (human) 2:74216242-74343414 1 7 7 15 9 24 0.00567450031453884 0.0360870450814976 0.0357960861037708 0.0762313150506373 0.0418840961321016 0.127581544328156 0.0258525438332691 0.0818989851702983 -1.66353932966793 0.00888039557006169 0.0377493925239132 DOWN ENSG00000246090 RP11-696N14.1 - - - - - - - 4:99088857-99301356 3 4 3 11 11 12 0.0259296052924794 0.0314171299103577 0.0233721175092574 0.0851749932277531 0.0779969330095553 0.0971899158562027 0.0269062842373648 0.086787280697837 -1.68954045250188 0.00888161496241598 0.0377493925239132 DOWN ENSG00000273348 RP11-535A5.1 - - - - - - - 18:22347846-22348252 0 0 0 1 4 3 0 0 0 0.155648141279636 0.570360362750721 0.488592717771878 0 0.404867073934078 -Inf 0.00891738581240317 0.037874468067077 DOWN ENSG00000167588 GPD1 glycerol-3-phosphate dehydrogenase 1 [Source:HGNC Symbol;Acc:HGNC:4455] GO:0032991|GO:0005623|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0043227|GO:0048037|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0042802|GO:0044262|GO:0044255|GO:0006725|GO:1901360|GO:0006082|GO:0034641|GO:0015980|GO:0044281|GO:0031982|GO:0019637|GO:0031325|GO:0046483|GO:0016614|GO:0043231|GO:0010243|GO:0005737|GO:0005975|GO:0046983|GO:0051186|GO:0006139|GO:0055086|GO:0009331|GO:0006629|GO:0070062|GO:0042180|GO:0050662|GO:0000166|GO:0006091|GO:0022900|GO:0044249|GO:0010033|GO:0031323|GO:0055114|GO:0006109|GO:0005829|GO:0008654|GO:0046486|GO:0014074|GO:0006127|GO:0034097|GO:0019693|GO:0046683|GO:0071417|GO:0044275|GO:0009116|GO:0022904|GO:0006638|GO:0016616|GO:0005996|GO:0005739|GO:0051591|GO:0016052|GO:0014070|GO:0043467|GO:0006796|GO:0051174|GO:0008610|GO:0071310|GO:0045333|GO:0019439|GO:0006116|GO:0016901|GO:0046434|GO:0016051|GO:0042803|GO:0051287|GO:0006644|GO:0006757|GO:0006110|GO:0019318|GO:0009259|GO:0046474|GO:0009117|GO:0004368|GO:0045821|GO:0016310|GO:0071407|GO:0006072|GO:0009132|GO:0006163|GO:0071345|GO:0046168|GO:0019752|GO:0006639|GO:0034612|GO:0009166|GO:0006096|GO:0071320|GO:0004367|GO:0042278|GO:0006650|GO:0019319|GO:0006654|GO:0046939|GO:1903578|GO:0071356|GO:0006006|GO:0042325|GO:0046473|GO:0032787|GO:0006165|GO:0042327|GO:0006641|GO:0019432|GO:0046034|GO:0019674|GO:0046031|GO:0006094|GO:0006090|GO:0006734 macromolecular complex|cell|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|membrane-bounded organelle|cofactor binding|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|protein complex|regulation of metabolic process|identical protein binding|cellular carbohydrate metabolic process|cellular lipid metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|organic acid metabolic process|cellular nitrogen compound metabolic process|energy derivation by oxidation of organic compounds|small molecule metabolic process|vesicle|organophosphate metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|oxidoreductase activity, acting on CH-OH group of donors|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|carbohydrate metabolic process|protein dimerization activity|cofactor metabolic process|nucleobase-containing compound metabolic process|nucleobase-containing small molecule metabolic process|glycerol-3-phosphate dehydrogenase complex|lipid metabolic process|extracellular exosome|cellular ketone metabolic process|coenzyme binding|nucleotide binding|generation of precursor metabolites and energy|electron transport chain|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|oxidation-reduction process|regulation of carbohydrate metabolic process|cytosol|phospholipid biosynthetic process|glycerolipid metabolic process|response to purine-containing compound|glycerophosphate shuttle|response to cytokine|ribose phosphate metabolic process|response to organophosphorus|cellular response to organonitrogen compound|cellular carbohydrate catabolic process|nucleoside metabolic process|respiratory electron transport chain|neutral lipid metabolic process|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|monosaccharide metabolic process|mitochondrion|response to cAMP|carbohydrate catabolic process|response to organic cyclic compound|regulation of generation of precursor metabolites and energy|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|lipid biosynthetic process|cellular response to organic substance|cellular respiration|aromatic compound catabolic process|NADH oxidation|oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|organophosphate catabolic process|carbohydrate biosynthetic process|protein homodimerization activity|NAD binding|phospholipid metabolic process|ATP generation from ADP|regulation of glycolytic process|hexose metabolic process|ribonucleotide metabolic process|glycerophospholipid biosynthetic process|nucleotide metabolic process|glycerol-3-phosphate dehydrogenase activity|positive regulation of glycolytic process|phosphorylation|cellular response to organic cyclic compound|glycerol-3-phosphate metabolic process|nucleoside diphosphate metabolic process|purine nucleotide metabolic process|cellular response to cytokine stimulus|glycerol-3-phosphate catabolic process|carboxylic acid metabolic process|acylglycerol metabolic process|response to tumor necrosis factor|nucleotide catabolic process|glycolytic process|cellular response to cAMP|glycerol-3-phosphate dehydrogenase [NAD+] activity|purine nucleoside metabolic process|glycerophospholipid metabolic process|hexose biosynthetic process|phosphatidic acid biosynthetic process|nucleotide phosphorylation|regulation of ATP metabolic process|cellular response to tumor necrosis factor|glucose metabolic process|regulation of phosphorylation|phosphatidic acid metabolic process|monocarboxylic acid metabolic process|nucleoside diphosphate phosphorylation|positive regulation of phosphorylation|triglyceride metabolic process|triglyceride biosynthetic process|ATP metabolic process|NAD metabolic process|ADP metabolic process|gluconeogenesis|pyruvate metabolic process|NADH metabolic process K00006 glycerol-3-phosphate dehydrogenase (NAD+)[1.1.1.8] hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) 12:50103819-50111319 19 15 15 6 6 10 0.242418980247039 0.173942993478339 0.1725536446201 0.0685939963277432 0.0628075399457639 0.119575752259665 0.196305206115159 0.083659096177724 1.23050411749765 0.00894150546211263 0.0379553112563501 UP ENSG00000104432 IL7 interleukin 7 [Source:HGNC Symbol;Acc:HGNC:6023] GO:0032502|GO:0040007|GO:0002376|GO:0023052|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0071704|GO:0006955|GO:0023051|GO:0009653|GO:0045927|GO:0007155|GO:0040008|GO:0023057|GO:0005615|GO:0002684|GO:0050793|GO:0048589|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0008284|GO:0042127|GO:1903706|GO:0016337|GO:0006959|GO:0045595|GO:0070661|GO:0050867|GO:0010941|GO:0007275|GO:0048513|GO:0070489|GO:0005102|GO:0046620|GO:0030155|GO:0035265|GO:0098609|GO:0045597|GO:0007267|GO:0009887|GO:0042592|GO:0002696|GO:0001775|GO:0009966|GO:0048771|GO:0048639|GO:0048871|GO:0060548|GO:0010646|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0046622|GO:0007165|GO:0009968|GO:0048638|GO:0045785|GO:0008219|GO:0050790|GO:0043086|GO:0048869|GO:0051249|GO:0042113|GO:0010468|GO:0005126|GO:0032943|GO:0007166|GO:0070851|GO:0030097|GO:0030098|GO:0043069|GO:2001234|GO:0001894|GO:0034109|GO:0005125|GO:0048872|GO:0051251|GO:0046849|GO:0022407|GO:0007159|GO:0042110|GO:0012501|GO:0010467|GO:0046651|GO:0030154|GO:0022409|GO:0008083|GO:0043067|GO:0045165|GO:0097190|GO:2001237|GO:0002521|GO:0050863|GO:0005139|GO:2001240|GO:0097192|GO:0048873|GO:0030217|GO:2001236|GO:0045619|GO:0034112|GO:0050871|GO:0070486|GO:0045453|GO:0050864|GO:0002360|GO:0042981|GO:0043066|GO:0042100|GO:0050870|GO:0097191|GO:0045621|GO:0050671|GO:0006915|GO:1903039|GO:0032946|GO:0045582|GO:0030890|GO:0045580|GO:2001239|GO:0030888|GO:0071593 developmental process|growth|immune system process|signaling|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|organic substance metabolic process|immune response|regulation of signaling|anatomical structure morphogenesis|positive regulation of growth|cell adhesion|regulation of growth|negative regulation of signaling|extracellular space|positive regulation of immune system process|regulation of developmental process|developmental growth|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|positive regulation of cell proliferation|regulation of cell proliferation|regulation of hemopoiesis|single organismal cell-cell adhesion|humoral immune response|regulation of cell differentiation|leukocyte proliferation|positive regulation of cell activation|regulation of cell death|multicellular organism development|animal organ development|T cell aggregation|receptor binding|regulation of organ growth|regulation of cell adhesion|organ growth|cell-cell adhesion|positive regulation of cell differentiation|cell-cell signaling|organ morphogenesis|homeostatic process|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|tissue remodeling|positive regulation of developmental growth|multicellular organismal homeostasis|negative regulation of cell death|regulation of cell communication|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|positive regulation of organ growth|signal transduction|negative regulation of signal transduction|regulation of developmental growth|positive regulation of cell adhesion|cell death|regulation of catalytic activity|negative regulation of catalytic activity|cellular developmental process|regulation of lymphocyte activation|B cell activation|regulation of gene expression|cytokine receptor binding|mononuclear cell proliferation|cell surface receptor signaling pathway|growth factor receptor binding|hemopoiesis|lymphocyte differentiation|negative regulation of programmed cell death|negative regulation of apoptotic signaling pathway|tissue homeostasis|homotypic cell-cell adhesion|cytokine activity|homeostasis of number of cells|positive regulation of lymphocyte activation|bone remodeling|regulation of cell-cell adhesion|leukocyte cell-cell adhesion|T cell activation|programmed cell death|gene expression|lymphocyte proliferation|cell differentiation|positive regulation of cell-cell adhesion|growth factor activity|regulation of programmed cell death|cell fate commitment|apoptotic signaling pathway|negative regulation of extrinsic apoptotic signaling pathway|leukocyte differentiation|regulation of T cell activation|interleukin-7 receptor binding|negative regulation of extrinsic apoptotic signaling pathway in absence of ligand|extrinsic apoptotic signaling pathway in absence of ligand|homeostasis of number of cells within a tissue|T cell differentiation|regulation of extrinsic apoptotic signaling pathway|regulation of lymphocyte differentiation|positive regulation of homotypic cell-cell adhesion|positive regulation of B cell activation|leukocyte aggregation|bone resorption|regulation of B cell activation|T cell lineage commitment|regulation of apoptotic process|negative regulation of apoptotic process|B cell proliferation|positive regulation of T cell activation|extrinsic apoptotic signaling pathway|positive regulation of lymphocyte differentiation|positive regulation of lymphocyte proliferation|apoptotic process|positive regulation of leukocyte cell-cell adhesion|positive regulation of mononuclear cell proliferation|positive regulation of T cell differentiation|positive regulation of B cell proliferation|regulation of T cell differentiation|regulation of extrinsic apoptotic signaling pathway in absence of ligand|regulation of B cell proliferation|lymphocyte aggregation K05431 interleukin 7[-] hsa04151|hsa04060|hsa04630|hsa04640 PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human) 8:78675743-78805523 0 0 0 3 4 1 0 0 0 0.0271586426734973 0.0331623810913633 0.00946939219681687 0 0.0232634719872258 -Inf 0.00894464593151484 0.0379632441909929 DOWN ENSG00000175147 TMEM51-AS1 TMEM51 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:26301] - - - - - - 1:15111815-15152464 6 11 8 9 24 47 0.0468020928196946 0.0779875107551427 0.0562664772798531 0.0629020306964589 0.15361008475244 0.343609741205907 0.0603520269515635 0.186707285551602 -1.62930409391933 0.00896323130394843 0.0380205040278597 DOWN ENSG00000274265 CH17-189H20.1 - - - - - - - 1:149176022-149251013 5 4 7 16 12 18 0.219826566323974 0.159819271793833 0.277447476569376 0.630223445305973 0.432857752807684 0.741631106463474 0.219031104895728 0.601570768192377 -1.45759870120922 0.008994908925759 0.0381440356632968 DOWN ENSG00000101222 SPEF1 sperm flagellar 1 [Source:HGNC Symbol;Acc:HGNC:15874] GO:0005623|GO:0005488|GO:0042995|GO:0043229|GO:0005622|GO:0005515|GO:0005929|GO:0005930|GO:0031514|GO:0005737|GO:0005856 cell|binding|cell projection|intracellular organelle|intracellular|protein binding|cilium|axoneme|motile cilium|cytoplasm|cytoskeleton - - - - 20:3777504-3781448 16 24 19 51 49 30 0.472569214246154 0.644215135656646 0.505949734346843 1.34961474139061 1.18742279887502 0.830419385525324 0.540911361416548 1.12248564193032 -1.05323288552101 0.00902485864518213 0.0382493086305036 DOWN ENSG00000235029 MNX1-AS2 MNX1 antisense RNA 2 [Source:HGNC Symbol;Acc:HGNC:40278] - - - - - - 7:157006307-157007132 5 7 7 2 1 2 0.945724452447257 1.20331962355978 1.19361761978643 0.33893504067826 0.155249271615916 0.354469226618813 1.11422056526449 0.282884512970996 1.97774974826348 0.00908992538163821 0.0384977489492732 UP ENSG00000038295 TLL1 tolloid like 1 [Source:HGNC Symbol;Acc:HGNC:11843] GO:0032502|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0003824|GO:0071704|GO:0043167|GO:0016043|GO:0016787|GO:0031224|GO:0005515|GO:0048856|GO:0007275|GO:0043062|GO:0043169|GO:0008233|GO:0048869|GO:0016021|GO:0019538|GO:0046872|GO:0022617|GO:0006508|GO:0030198|GO:0030154|GO:0001501|GO:0008237|GO:0005509|GO:0004175|GO:0046914|GO:0008270|GO:0004222 developmental process|membrane|cellular process|extracellular region|metabolic process|binding|catalytic activity|organic substance metabolic process|ion binding|cellular component organization|hydrolase activity|intrinsic component of membrane|protein binding|anatomical structure development|multicellular organism development|extracellular structure organization|cation binding|peptidase activity|cellular developmental process|integral component of membrane|protein metabolic process|metal ion binding|extracellular matrix disassembly|proteolysis|extracellular matrix organization|cell differentiation|skeletal system development|metallopeptidase activity|calcium ion binding|endopeptidase activity|transition metal ion binding|zinc ion binding|metalloendopeptidase activity - - - - 4:165873258-166103895 1 1 8 10 9 18 0.00684662281565537 0.00622269028027664 0.0493638173349176 0.0613204843332379 0.0505356581717724 0.115449346971723 0.0208110434769499 0.0757684964922444 -1.86424881574528 0.00912628538604511 0.0386243441898201 DOWN ENSG00000227582 ADGRF5P1 adhesion G protein-coupled receptor F5 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:32922] - - - - - - 9:62860873-62864957 12 21 24 5 7 13 0.401356508901597 0.638328022845546 0.723691016343918 0.149821373015674 0.192088997183767 0.407496795939073 0.587791849363687 0.249802388712838 1.23451808129333 0.00913932912034689 0.0386685844045969 UP ENSG00000241170 RP11-147I3.1 - - - - - - - 11:74876286-74920022 11 9 20 31 25 38 0.279591204780548 0.207910939047609 0.458340294622447 0.705968470533168 0.521358733298794 0.905188785970138 0.315280812816868 0.710838663267367 -1.17288477924523 0.00914756104017246 0.0386979293316294 DOWN ENSG00000136895 GARNL3 GTPase activating Rap/RanGAP domain-like 3 [Source:HGNC Symbol;Acc:HGNC:25425] GO:0023052|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0050794|GO:0023051|GO:0009893|GO:0030234|GO:0019222|GO:0008047|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005096|GO:0051345|GO:0030695|GO:0035556|GO:1902531|GO:0043087|GO:0043547|GO:0051056|GO:0007264 signaling|cellular process|metabolic process|response to stimulus|cellular response to stimulus|regulation of cellular process|regulation of signaling|positive regulation of metabolic process|enzyme regulator activity|regulation of metabolic process|enzyme activator activity|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|regulation of intracellular signal transduction|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - 9:127224265-127393660 8 15 33 28 37 95 0.0399314447523337 0.068050240338996 0.148517559926235 0.125227560142497 0.151535493545841 0.444423223141461 0.0854997483391882 0.240395425609933 -1.49141736515895 0.0091528331106592 0.0387092618905822 DOWN ENSG00000225535 LINC01393 long intergenic non-protein coding RNA 1393 [Source:HGNC Symbol;Acc:HGNC:50669] - - - - - - 7:115078958-115126314 1 1 1 5 4 8 0.023401684332875 0.0212690895294112 0.021079589226139 0.104785781722272 0.0767647710448225 0.175382433787085 0.0219167876961417 0.118977662184727 -2.4405824701752 0.00925039947355311 0.0390665477271827 DOWN ENSG00000245213 RP11-10K16.1 - - - - - - - 4:173131928-173169652 17 19 38 43 46 74 0.308413362552771 0.313282678676633 0.621569435117049 0.698969090735015 0.684725837881905 1.25821487784169 0.414421825448818 0.88063660215287 -1.08744682437785 0.00927890322975835 0.0391536928651881 DOWN ENSG00000272202 RP11-157F20.3 - - - - - - - 3:57078943-57080101 9 3 1 0 1 0 0.549296977573714 0.166429966259774 0.0549997220188477 0 0.0500976942056535 0 0.256908888617445 0.0166992314018845 3.94340319801606 0.00928309556528841 0.0391547803060356 UP ENSG00000124212 PTGIS prostaglandin I2 (prostacyclin) synthase [Source:HGNC Symbol;Acc:HGNC:9603] GO:0032502|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0097159|GO:0009892|GO:0048523|GO:0016491|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0044702|GO:0042175|GO:0071704|GO:0043167|GO:0009628|GO:0044237|GO:0003006|GO:0023051|GO:0009653|GO:0043227|GO:0071944|GO:0009605|GO:0016853|GO:0032504|GO:0009058|GO:0031224|GO:0005615|GO:0050793|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0048646|GO:0031090|GO:0048609|GO:0019222|GO:0048514|GO:0001893|GO:0046697|GO:1903409|GO:0044255|GO:0001890|GO:0006725|GO:0009888|GO:1901360|GO:0001568|GO:0010941|GO:0006082|GO:0044853|GO:0007275|GO:0009410|GO:0048513|GO:0034641|GO:0097194|GO:0044281|GO:0006952|GO:2001057|GO:0019637|GO:0046483|GO:0033554|GO:0007566|GO:0010942|GO:0043231|GO:0048608|GO:0043169|GO:0005737|GO:0016705|GO:0009611|GO:0072593|GO:0009966|GO:0009890|GO:0051186|GO:0060135|GO:0006769|GO:0010646|GO:0006139|GO:0016860|GO:0004497|GO:0001525|GO:0055086|GO:0007154|GO:0044092|GO:0007565|GO:0006629|GO:0007165|GO:0005783|GO:0008219|GO:0006805|GO:0001666|GO:0016021|GO:0009967|GO:0044249|GO:0010033|GO:0098857|GO:0031324|GO:0031323|GO:0051090|GO:0055114|GO:0005901|GO:0010468|GO:0034645|GO:0046872|GO:0020037|GO:0001944|GO:0061458|GO:0072358|GO:0034097|GO:0010629|GO:0050727|GO:0051252|GO:0006631|GO:1903427|GO:0008116|GO:1900117|GO:2000377|GO:0071456|GO:0006954|GO:0046209|GO:0035358|GO:0045766|GO:0035360|GO:0071466|GO:0045765|GO:0050728|GO:0045428|GO:0009820|GO:0043433|GO:2000378|GO:0071453|GO:0012501|GO:0006796|GO:0043603|GO:1901342|GO:0010467|GO:0008610|GO:0071310|GO:1900119|GO:0006809|GO:0009059|GO:0045121|GO:0043068|GO:0016070|GO:0072359|GO:0005634|GO:0043067|GO:0006690|GO:1903426|GO:0030522|GO:0097190|GO:0006766|GO:0033559|GO:0070555|GO:0043065|GO:0045892|GO:0009117|GO:0032774|GO:0035357|GO:0001676|GO:2001141|GO:1902679|GO:0019369|GO:0006633|GO:0042981|GO:0071345|GO:0032088|GO:0046914|GO:0019752|GO:0045019|GO:0046456|GO:0006767|GO:0006351|GO:0006915|GO:0006355|GO:0070741|GO:0036294|GO:0006636|GO:0005506|GO:1903507|GO:0071347|GO:1903506|GO:0071354|GO:0019371|GO:0032787|GO:0006693|GO:0019674|GO:0001516 developmental process|reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|oxidoreductase activity|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|single organism reproductive process|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|response to abiotic stimulus|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cell periphery|response to external stimulus|isomerase activity|multicellular organism reproduction|biosynthetic process|intrinsic component of membrane|extracellular space|regulation of developmental process|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|anatomical structure development|anatomical structure formation involved in morphogenesis|organelle membrane|multicellular organismal reproductive process|regulation of metabolic process|blood vessel morphogenesis|maternal placenta development|decidualization|reactive oxygen species biosynthetic process|cellular lipid metabolic process|placenta development|cellular aromatic compound metabolic process|tissue development|organic cyclic compound metabolic process|blood vessel development|regulation of cell death|organic acid metabolic process|plasma membrane raft|multicellular organism development|response to xenobiotic stimulus|animal organ development|cellular nitrogen compound metabolic process|execution phase of apoptosis|small molecule metabolic process|defense response|reactive nitrogen species metabolic process|organophosphate metabolic process|heterocycle metabolic process|cellular response to stress|embryo implantation|positive regulation of cell death|intracellular membrane-bounded organelle|reproductive structure development|cation binding|cytoplasm|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|response to wounding|reactive oxygen species metabolic process|regulation of signal transduction|negative regulation of biosynthetic process|cofactor metabolic process|maternal process involved in female pregnancy|nicotinamide metabolic process|regulation of cell communication|nucleobase-containing compound metabolic process|intramolecular oxidoreductase activity|monooxygenase activity|angiogenesis|nucleobase-containing small molecule metabolic process|cell communication|negative regulation of molecular function|female pregnancy|lipid metabolic process|signal transduction|endoplasmic reticulum|cell death|xenobiotic metabolic process|response to hypoxia|integral component of membrane|positive regulation of signal transduction|cellular biosynthetic process|response to organic substance|membrane microdomain|negative regulation of cellular metabolic process|regulation of cellular metabolic process|regulation of sequence-specific DNA binding transcription factor activity|oxidation-reduction process|caveola|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|heme binding|vasculature development|reproductive system development|cardiovascular system development|response to cytokine|negative regulation of gene expression|regulation of inflammatory response|regulation of RNA metabolic process|fatty acid metabolic process|negative regulation of reactive oxygen species biosynthetic process|prostaglandin-I synthase activity|regulation of execution phase of apoptosis|regulation of reactive oxygen species metabolic process|cellular response to hypoxia|inflammatory response|nitric oxide metabolic process|regulation of peroxisome proliferator activated receptor signaling pathway|positive regulation of angiogenesis|positive regulation of peroxisome proliferator activated receptor signaling pathway|cellular response to xenobiotic stimulus|regulation of angiogenesis|negative regulation of inflammatory response|regulation of nitric oxide biosynthetic process|alkaloid metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of reactive oxygen species metabolic process|cellular response to oxygen levels|programmed cell death|phosphate-containing compound metabolic process|cellular amide metabolic process|regulation of vasculature development|gene expression|lipid biosynthetic process|cellular response to organic substance|positive regulation of execution phase of apoptosis|nitric oxide biosynthetic process|macromolecule biosynthetic process|membrane raft|positive regulation of programmed cell death|RNA metabolic process|circulatory system development|nucleus|regulation of programmed cell death|icosanoid metabolic process|regulation of reactive oxygen species biosynthetic process|intracellular receptor signaling pathway|apoptotic signaling pathway|vitamin metabolic process|unsaturated fatty acid metabolic process|response to interleukin-1|positive regulation of apoptotic process|negative regulation of transcription, DNA-templated|nucleotide metabolic process|RNA biosynthetic process|peroxisome proliferator activated receptor signaling pathway|long-chain fatty acid metabolic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|arachidonic acid metabolic process|fatty acid biosynthetic process|regulation of apoptotic process|cellular response to cytokine stimulus|negative regulation of NF-kappaB transcription factor activity|transition metal ion binding|carboxylic acid metabolic process|negative regulation of nitric oxide biosynthetic process|icosanoid biosynthetic process|water-soluble vitamin metabolic process|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|response to interleukin-6|cellular response to decreased oxygen levels|unsaturated fatty acid biosynthetic process|iron ion binding|negative regulation of nucleic acid-templated transcription|cellular response to interleukin-1|regulation of nucleic acid-templated transcription|cellular response to interleukin-6|cyclooxygenase pathway|monocarboxylic acid metabolic process|prostaglandin metabolic process|NAD metabolic process|prostaglandin biosynthetic process K01831 prostacyclin synthase[5.3.99.4] hsa01100|hsa00590 Metabolic pathways - Homo sapiens (human)|Arachidonic acid metabolism - Homo sapiens (human) 20:49503874-49568146 10 10 12 20 13 77 0.121598010913125 0.110516249061491 0.13156895718765 0.217904922455673 0.129701432096095 0.877537741935346 0.121227739054089 0.408381365495705 -1.75219718655632 0.00929789013488946 0.0391849671333098 DOWN ENSG00000228043 AC097721.2 - - - - - - - 2:138418284-138501698 1 0 1 6 7 2 0.0424006551363774 0 0.0381933360214766 0.227852076477536 0.243420149217296 0.0794316900871397 0.0268646637192847 0.183567971927324 -2.77253268187916 0.00929944034767536 0.0391849671333098 DOWN ENSG00000232334 RP11-47G11.2 - - - - - - - 10:124004304-124004828 0 0 0 1 3 4 0 0 0 0.120664368572975 0.331679164579284 0.5050342504969 0 0.319125927883053 -Inf 0.00929849548657743 0.0391849671333098 DOWN ENSG00000236268 LINC01361 long intergenic non-protein coding RNA 1361 [Source:HGNC Symbol;Acc:HGNC:50595] - - - - - - 1:82973882-82986208 0 0 0 1 3 4 0 0 0 0.0228201705694568 0.0627275077104193 0.0955126014088157 0 0.0603534265628973 -Inf 0.00929886907546911 0.0391849671333098 DOWN ENSG00000279662 RP11-609N14.4 - - - - - - - 16:10445309-10449747 16 18 21 30 38 54 0.254968071214133 0.260682909984963 0.301713385391781 0.428331034015093 0.496839987975323 0.80645491121856 0.272454788863626 0.577208644402992 -1.08307605711246 0.00931172329308596 0.0392256507960757 DOWN ENSG00000064300 NGFR nerve growth factor receptor [Source:HGNC Symbol;Acc:HGNC:7809] GO:0040011|GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0048511|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0033218|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0043229|GO:0006950|GO:0007623|GO:0071704|GO:0006955|GO:0009986|GO:0044237|GO:0051641|GO:0038023|GO:0023051|GO:0044297|GO:0009653|GO:0016043|GO:0051707|GO:0043227|GO:0071944|GO:0009607|GO:0009605|GO:0009893|GO:0031252|GO:0031224|GO:0050793|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0019222|GO:0070678|GO:0051726|GO:0042127|GO:0007049|GO:0050804|GO:0042391|GO:0042277|GO:0006935|GO:0045595|GO:0009897|GO:0009888|GO:0048468|GO:0043025|GO:0019838|GO:0006810|GO:0051130|GO:0031643|GO:0010941|GO:0031641|GO:0007275|GO:0045596|GO:0048513|GO:0050877|GO:0005102|GO:0006952|GO:0031982|GO:0031325|GO:0051128|GO:0033554|GO:0050806|GO:0010942|GO:0032922|GO:1900076|GO:0061061|GO:0005887|GO:0045786|GO:0045597|GO:0043231|GO:0019899|GO:0010243|GO:0004888|GO:0005737|GO:0051902|GO:0007267|GO:0009611|GO:0003254|GO:0005635|GO:0006928|GO:0042592|GO:0072593|GO:0043005|GO:0009966|GO:0043204|GO:0032809|GO:0045184|GO:0036477|GO:0006979|GO:0060548|GO:0010646|GO:0031226|GO:0009617|GO:0008104|GO:0007154|GO:0007165|GO:0005783|GO:0032589|GO:0051649|GO:2000021|GO:0009725|GO:0008219|GO:0031256|GO:0050790|GO:0030030|GO:0031253|GO:0048869|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0098857|GO:0031323|GO:0005794|GO:0005768|GO:0050768|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0043121|GO:0031344|GO:0010468|GO:0005126|GO:1901215|GO:0007166|GO:0032224|GO:0051899|GO:0033993|GO:0051900|GO:0043412|GO:0034097|GO:0031410|GO:0002237|GO:0010720|GO:0043069|GO:0032590|GO:0048878|GO:1901216|GO:0070997|GO:0010721|GO:0015031|GO:1901652|GO:0031346|GO:0000904|GO:0071417|GO:0016023|GO:0005035|GO:0051968|GO:0036211|GO:2000377|GO:0060537|GO:0046907|GO:0005791|GO:0006954|GO:0031345|GO:0007600|GO:0031981|GO:0050769|GO:0043434|GO:0034599|GO:0051966|GO:0031644|GO:0051247|GO:0070848|GO:0006508|GO:0031988|GO:0005654|GO:0022604|GO:1901214|GO:0051881|GO:0034613|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0032990|GO:0007399|GO:2001273|GO:0071310|GO:0097485|GO:0051246|GO:0010770|GO:0051020|GO:0030154|GO:0048858|GO:0045121|GO:0043068|GO:0007517|GO:1902531|GO:0008643|GO:0032870|GO:0032496|GO:0005634|GO:0043067|GO:0051960|GO:0097190|GO:0008366|GO:0010827|GO:0044389|GO:0001540|GO:0048666|GO:0030182|GO:0031625|GO:0051896|GO:0007411|GO:0043491|GO:0060538|GO:0010975|GO:0019221|GO:0005031|GO:0048406|GO:0031401|GO:0043065|GO:0019233|GO:0030139|GO:1901653|GO:0043408|GO:0010769|GO:0043523|GO:0030162|GO:0071363|GO:0051882|GO:0046324|GO:0016310|GO:0051897|GO:0033619|GO:0038179|GO:0052547|GO:0061564|GO:0006886|GO:0007167|GO:0030135|GO:0031267|GO:0071375|GO:0043410|GO:0035914|GO:0042981|GO:0071345|GO:0050801|GO:0043066|GO:0032868|GO:0051402|GO:0051057|GO:0034612|GO:0042552|GO:0045665|GO:0043524|GO:0051056|GO:0014706|GO:0050772|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050767|GO:0048812|GO:0010976|GO:0010977|GO:0006915|GO:0050771|GO:0033500|GO:0045666|GO:0048011|GO:0042593|GO:0030136|GO:0007265|GO:0046578|GO:0008645|GO:0031293|GO:0017016|GO:0007409|GO:0043281|GO:0006468|GO:0048699|GO:0007519|GO:0071356|GO:0046579|GO:0042325|GO:0001932|GO:0032869|GO:0033209|GO:0001934|GO:0045334|GO:0050770|GO:0045664|GO:0042327|GO:0007268|GO:0007169|GO:0052548|GO:0017137|GO:0007271|GO:0007270|GO:0015758|GO:0035023|GO:0005168|GO:2000116|GO:0007266|GO:0035025|GO:0046323|GO:0035249 locomotion|developmental process|signal transducer activity|immune system process|signaling|cell|rhythmic process|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|cellular response to stimulus|cell projection|amide binding|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|intracellular organelle|response to stress|circadian rhythm|organic substance metabolic process|immune response|cell surface|cellular metabolic process|cellular localization|signaling receptor activity|regulation of signaling|cell body|anatomical structure morphogenesis|cellular component organization|response to other organism|membrane-bounded organelle|cell periphery|response to biotic stimulus|response to external stimulus|positive regulation of metabolic process|cell leading edge|intrinsic component of membrane|regulation of developmental process|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|regulation of metabolic process|preprotein binding|regulation of cell cycle|regulation of cell proliferation|cell cycle|modulation of synaptic transmission|regulation of membrane potential|peptide binding|chemotaxis|regulation of cell differentiation|external side of plasma membrane|tissue development|cell development|neuronal cell body|growth factor binding|transport|positive regulation of cellular component organization|positive regulation of myelination|regulation of cell death|regulation of myelination|multicellular organism development|negative regulation of cell differentiation|animal organ development|neurological system process|receptor binding|defense response|vesicle|positive regulation of cellular metabolic process|regulation of cellular component organization|cellular response to stress|positive regulation of synaptic transmission|positive regulation of cell death|circadian regulation of gene expression|regulation of cellular response to insulin stimulus|muscle structure development|integral component of plasma membrane|negative regulation of cell cycle|positive regulation of cell differentiation|intracellular membrane-bounded organelle|enzyme binding|response to organonitrogen compound|transmembrane signaling receptor activity|cytoplasm|negative regulation of mitochondrial depolarization|cell-cell signaling|response to wounding|regulation of membrane depolarization|nuclear envelope|movement of cell or subcellular component|homeostatic process|reactive oxygen species metabolic process|neuron projection|regulation of signal transduction|perikaryon|neuronal cell body membrane|establishment of protein localization|somatodendritic compartment|response to oxidative stress|negative regulation of cell death|regulation of cell communication|intrinsic component of plasma membrane|response to bacterium|protein localization|cell communication|signal transduction|endoplasmic reticulum|neuron projection membrane|establishment of localization in cell|regulation of ion homeostasis|response to hormone|cell death|leading edge membrane|regulation of catalytic activity|cell projection organization|cell projection membrane|cellular developmental process|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|membrane microdomain|regulation of cellular metabolic process|Golgi apparatus|endosome|negative regulation of neurogenesis|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|neurotrophin binding|regulation of cell projection organization|regulation of gene expression|cytokine receptor binding|negative regulation of neuron death|cell surface receptor signaling pathway|positive regulation of synaptic transmission, cholinergic|membrane depolarization|response to lipid|regulation of mitochondrial depolarization|macromolecule modification|response to cytokine|cytoplasmic vesicle|response to molecule of bacterial origin|positive regulation of cell development|negative regulation of programmed cell death|dendrite membrane|chemical homeostasis|positive regulation of neuron death|neuron death|negative regulation of cell development|protein transport|response to peptide|positive regulation of cell projection organization|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|cytoplasmic, membrane-bounded vesicle|death receptor activity|positive regulation of synaptic transmission, glutamatergic|protein modification process|regulation of reactive oxygen species metabolic process|muscle tissue development|intracellular transport|rough endoplasmic reticulum|inflammatory response|negative regulation of cell projection organization|sensory perception|nuclear lumen|positive regulation of neurogenesis|response to peptide hormone|cellular response to oxidative stress|regulation of synaptic transmission, glutamatergic|regulation of neurological system process|positive regulation of protein metabolic process|response to growth factor|proteolysis|membrane-bounded vesicle|nucleoplasm|regulation of cell morphogenesis|regulation of neuron death|regulation of mitochondrial membrane potential|cellular protein localization|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|cell part morphogenesis|nervous system development|regulation of glucose import in response to insulin stimulus|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|positive regulation of cell morphogenesis involved in differentiation|GTPase binding|cell differentiation|cell projection morphogenesis|membrane raft|positive regulation of programmed cell death|muscle organ development|regulation of intracellular signal transduction|carbohydrate transport|cellular response to hormone stimulus|response to lipopolysaccharide|nucleus|regulation of programmed cell death|regulation of nervous system development|apoptotic signaling pathway|axon ensheathment|regulation of glucose transport|ubiquitin-like protein ligase binding|beta-amyloid binding|neuron development|neuron differentiation|ubiquitin protein ligase binding|regulation of protein kinase B signaling|axon guidance|protein kinase B signaling|skeletal muscle organ development|regulation of neuron projection development|cytokine-mediated signaling pathway|tumor necrosis factor-activated receptor activity|nerve growth factor binding|positive regulation of protein modification process|positive regulation of apoptotic process|sensory perception of pain|endocytic vesicle|cellular response to peptide|regulation of MAPK cascade|regulation of cell morphogenesis involved in differentiation|regulation of neuron apoptotic process|regulation of proteolysis|cellular response to growth factor stimulus|mitochondrial depolarization|regulation of glucose import|phosphorylation|positive regulation of protein kinase B signaling|membrane protein proteolysis|neurotrophin signaling pathway|regulation of peptidase activity|axon development|intracellular protein transport|enzyme linked receptor protein signaling pathway|coated vesicle|small GTPase binding|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|skeletal muscle cell differentiation|regulation of apoptotic process|cellular response to cytokine stimulus|ion homeostasis|negative regulation of apoptotic process|response to insulin|neuron apoptotic process|positive regulation of small GTPase mediated signal transduction|response to tumor necrosis factor|myelination|negative regulation of neuron differentiation|negative regulation of neuron apoptotic process|regulation of small GTPase mediated signal transduction|striated muscle tissue development|positive regulation of axonogenesis|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|regulation of neurogenesis|neuron projection morphogenesis|positive regulation of neuron projection development|negative regulation of neuron projection development|apoptotic process|negative regulation of axonogenesis|carbohydrate homeostasis|positive regulation of neuron differentiation|neurotrophin TRK receptor signaling pathway|glucose homeostasis|clathrin-coated vesicle|Ras protein signal transduction|regulation of Ras protein signal transduction|hexose transport|membrane protein intracellular domain proteolysis|Ras GTPase binding|axonogenesis|regulation of cysteine-type endopeptidase activity involved in apoptotic process|protein phosphorylation|generation of neurons|skeletal muscle tissue development|cellular response to tumor necrosis factor|positive regulation of Ras protein signal transduction|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|tumor necrosis factor-mediated signaling pathway|positive regulation of protein phosphorylation|clathrin-coated endocytic vesicle|regulation of axonogenesis|regulation of neuron differentiation|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|regulation of endopeptidase activity|Rab GTPase binding|synaptic transmission, cholinergic|neuron-neuron synaptic transmission|glucose transport|regulation of Rho protein signal transduction|neurotrophin TRKA receptor binding|regulation of cysteine-type endopeptidase activity|Rho protein signal transduction|positive regulation of Rho protein signal transduction|glucose import|synaptic transmission, glutamatergic K02583 nerve growth factor receptor (TNFR superfamily member 16)[-] hsa04151|hsa04060|hsa04014|hsa04015|hsa05202|hsa04722 PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Rap1 signaling pathway - Homo sapiens (human)|Transcriptional misregulation in cancer - Homo sapiens (human)|Neurotrophin signaling pathway - Homo sapiens (human) 17:49495293-49515017 0 0 1 4 2 5 0 0 0.0130038102447663 0.0517183619802813 0.023677750677228 0.0676253046999168 0.0043346034149221 0.0476738057858087 -3.45922489155895 0.00934698702398946 0.0393516600193241 DOWN ENSG00000126947 ARMCX1 armadillo repeat containing, X-linked 1 [Source:HGNC Symbol;Acc:HGNC:18073] GO:0016020|GO:0005488|GO:0031224|GO:0005515|GO:0016021 membrane|binding|intrinsic component of membrane|protein binding|integral component of membrane - - - - X:101550531-101554700 0 0 1 4 2 5 0 0 0.0156428657226612 0.0622143338471997 0.0284830267042384 0.0813495076414705 0.0052142885742204 0.0573489560643029 -3.45922489155895 0.00934822713395345 0.0393516600193241 DOWN ENSG00000164161 HHIP hedgehog interacting protein [Source:HGNC Symbol;Acc:HGNC:14866] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0042995|GO:0048523|GO:0008283|GO:0016491|GO:0050794|GO:0071704|GO:0043167|GO:0009986|GO:0023051|GO:0009653|GO:0043227|GO:0048037|GO:0071944|GO:0023057|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0031090|GO:0048038|GO:0035239|GO:0009888|GO:0035295|GO:0007275|GO:0030324|GO:0048513|GO:0060170|GO:0090287|GO:0016614|GO:0005887|GO:0043169|GO:0005737|GO:0007389|GO:0001763|GO:0005975|GO:0009887|GO:0009966|GO:0048729|GO:0097108|GO:0030323|GO:0010646|GO:0031226|GO:0007154|GO:0007165|GO:0009968|GO:0061351|GO:0031253|GO:0048869|GO:0016021|GO:0010033|GO:0072089|GO:0055114|GO:0071774|GO:0060425|GO:0048705|GO:0040036|GO:0046872|GO:0007166|GO:0002009|GO:0060541|GO:0007405|GO:0048754|GO:0008589|GO:0061138|GO:0045879|GO:0003002|GO:0044344|GO:0070848|GO:0060429|GO:0007399|GO:0060562|GO:0071310|GO:0030154|GO:0001501|GO:0016901|GO:0008543|GO:0007224|GO:0071363|GO:0007167|GO:0009953|GO:0046914|GO:0060441|GO:0022008|GO:0048699|GO:0008270|GO:0007169 developmental process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|cell projection|negative regulation of cellular process|cell proliferation|oxidoreductase activity|regulation of cellular process|organic substance metabolic process|ion binding|cell surface|regulation of signaling|anatomical structure morphogenesis|membrane-bounded organelle|cofactor binding|cell periphery|negative regulation of signaling|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|cilium|organelle membrane|quinone binding|tube morphogenesis|tissue development|tube development|multicellular organism development|lung development|animal organ development|ciliary membrane|regulation of cellular response to growth factor stimulus|oxidoreductase activity, acting on CH-OH group of donors|integral component of plasma membrane|cation binding|cytoplasm|pattern specification process|morphogenesis of a branching structure|carbohydrate metabolic process|organ morphogenesis|regulation of signal transduction|tissue morphogenesis|hedgehog family protein binding|respiratory tube development|regulation of cell communication|intrinsic component of plasma membrane|cell communication|signal transduction|negative regulation of signal transduction|neural precursor cell proliferation|cell projection membrane|cellular developmental process|integral component of membrane|response to organic substance|stem cell proliferation|oxidation-reduction process|response to fibroblast growth factor|lung morphogenesis|skeletal system morphogenesis|regulation of fibroblast growth factor receptor signaling pathway|metal ion binding|cell surface receptor signaling pathway|morphogenesis of an epithelium|respiratory system development|neuroblast proliferation|branching morphogenesis of an epithelial tube|regulation of smoothened signaling pathway|morphogenesis of a branching epithelium|negative regulation of smoothened signaling pathway|regionalization|cellular response to fibroblast growth factor stimulus|response to growth factor|epithelium development|nervous system development|epithelial tube morphogenesis|cellular response to organic substance|cell differentiation|skeletal system development|oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|fibroblast growth factor receptor signaling pathway|smoothened signaling pathway|cellular response to growth factor stimulus|enzyme linked receptor protein signaling pathway|dorsal/ventral pattern formation|transition metal ion binding|epithelial tube branching involved in lung morphogenesis|neurogenesis|generation of neurons|zinc ion binding|transmembrane receptor protein tyrosine kinase signaling pathway K06231 hedgehog interacting protein[-] hsa05200|hsa04024|hsa05217|hsa04340 Pathways in cancer - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human)|Basal cell carcinoma - Homo sapiens (human)|Hedgehog signaling pathway - Homo sapiens (human) 4:144646021-144745271 0 0 1 4 2 5 0 0 0.00445922894857254 0.0177351109078236 0.00811950568868637 0.0231898736368655 0.00148640964952418 0.0163481634111252 -3.45922489155895 0.00934769156735531 0.0393516600193241 DOWN ENSG00000133687 TMTC1 transmembrane and tetratricopeptide repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:24099] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0005488|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0043227|GO:0031224|GO:0005622|GO:0005515|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0016021|GO:0005739|GO:0010467|GO:0016070|GO:0006396 cell|membrane|cellular process|metabolic process|binding|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|membrane-bounded organelle|intrinsic component of membrane|intracellular|protein binding|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|integral component of membrane|mitochondrion|gene expression|RNA metabolic process|RNA processing - - - - 12:29500840-29784759 0 0 1 3 1 10 0 0 0.00310253469385012 0.00925292021388501 0.00282601127150552 0.0322655490376513 0.00103417823128337 0.0147814935076806 -3.83723529768679 0.00936641404256326 0.0394004403024776 DOWN ENSG00000249082 C5orf66-AS1 C5orf66 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:49679] - - - - - - 5:135038831-135040047 3 7 3 13 18 10 0.160783196453745 0.340940560008603 0.144924834707024 0.624181079380931 0.791419034641574 0.502218159490593 0.215549530389791 0.639272757837699 -1.56841219633897 0.00940957277464713 0.0395652655794811 DOWN ENSG00000250802 ZBED3-AS1 ZBED3 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44188] - - - - - - 5:77086740-77166909 7 6 8 17 25 14 0.0465339790538111 0.0362488311694781 0.047948916076845 0.101253870426667 0.13635385346965 0.0872231433877321 0.0435772421000447 0.10827695576135 -1.31307943171825 0.00942372024308229 0.0396135939364938 DOWN ENSG00000130363 RSPH3 radial spoke 3 homolog (Chlamydomonas) [Source:HGNC Symbol;Acc:HGNC:21054] GO:0005488|GO:0005515 binding|protein binding - - - - 6:158972871-159000187 54 69 157 165 151 282 0.379665160724342 0.440895961446542 0.995221205073644 1.03940841168487 0.871063460645717 1.85815597348969 0.605260775748176 1.25620928194009 -1.05344806978725 0.00946355390775441 0.0397586459839713 DOWN ENSG00000228630 HOTAIR HOX transcript antisense RNA [Source:HGNC Symbol;Acc:HGNC:33510] - - - - - - 12:53962308-53974956 42 17 21 71 52 70 0.732119804268292 0.269323449975863 0.330040837297712 1.10889113838225 0.743718374743666 1.14355995821673 0.443828030513956 0.998723157114215 -1.17008403733248 0.0094920350447026 0.0398446589179628 DOWN ENSG00000253686 LINC01484 long intergenic non-protein coding RNA 1484 [Source:HGNC Symbol;Acc:HGNC:51136] - - - - - - 5:173707614-173746211 11 6 3 17 19 23 0.22845047648393 0.113248330145161 0.056165819675065 0.316336592839157 0.323762875311577 0.447675776259167 0.132621542101385 0.362591748136634 -1.45103095697954 0.0095517089797808 0.0400388542379073 DOWN ENSG00000243708 PLA2G4B phospholipase A2 group IVB [Source:HGNC Symbol;Acc:HGNC:9036] GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0006950|GO:0071704|GO:0009056|GO:0043167|GO:0044237|GO:0043227|GO:0008289|GO:0016787|GO:0009058|GO:0005622|GO:0005515|GO:0012505|GO:0031090|GO:0006575|GO:0044255|GO:0019866|GO:0006082|GO:0034641|GO:0043168|GO:0016788|GO:0044281|GO:0006952|GO:0005543|GO:0019637|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0006520|GO:0031966|GO:0007154|GO:0006629|GO:0007165|GO:0010008|GO:0044249|GO:0019538|GO:0010033|GO:0005768|GO:0007567|GO:0005740|GO:0005829|GO:0006658|GO:0008654|GO:0046486|GO:0046872|GO:0030968|GO:0016042|GO:0005769|GO:0006066|GO:0044242|GO:0009308|GO:0006631|GO:0006954|GO:0046470|GO:0005743|GO:0006986|GO:0005739|GO:0031901|GO:0005544|GO:0016298|GO:0006796|GO:0035556|GO:0044267|GO:0008610|GO:0071310|GO:0035967|GO:0034976|GO:0046434|GO:0052689|GO:0006644|GO:0006690|GO:0034620|GO:0004620|GO:0033559|GO:0009395|GO:0036152|GO:0004622|GO:0036498|GO:0046474|GO:0004623|GO:0001676|GO:0005509|GO:0019369|GO:0006576|GO:0036150|GO:0019752|GO:0036151|GO:0019932|GO:0006650|GO:0006654|GO:0047498|GO:0046473|GO:0032787|GO:0019722|GO:0046475|GO:0036148 reproduction|signaling|cell|membrane|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|response to stress|organic substance metabolic process|catabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|lipid binding|hydrolase activity|biosynthetic process|intracellular|protein binding|endomembrane system|organelle membrane|cellular modified amino acid metabolic process|cellular lipid metabolic process|organelle inner membrane|organic acid metabolic process|cellular nitrogen compound metabolic process|anion binding|hydrolase activity, acting on ester bonds|small molecule metabolic process|defense response|phospholipid binding|organophosphate metabolic process|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|cellular amino acid metabolic process|mitochondrial membrane|cell communication|lipid metabolic process|signal transduction|endosome membrane|cellular biosynthetic process|protein metabolic process|response to organic substance|endosome|parturition|mitochondrial envelope|cytosol|phosphatidylserine metabolic process|phospholipid biosynthetic process|glycerolipid metabolic process|metal ion binding|endoplasmic reticulum unfolded protein response|lipid catabolic process|early endosome|alcohol metabolic process|cellular lipid catabolic process|amine metabolic process|fatty acid metabolic process|inflammatory response|phosphatidylcholine metabolic process|mitochondrial inner membrane|response to unfolded protein|mitochondrion|early endosome membrane|calcium-dependent phospholipid binding|lipase activity|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|lipid biosynthetic process|cellular response to organic substance|cellular response to topologically incorrect protein|response to endoplasmic reticulum stress|organophosphate catabolic process|carboxylic ester hydrolase activity|phospholipid metabolic process|icosanoid metabolic process|cellular response to unfolded protein|phospholipase activity|unsaturated fatty acid metabolic process|phospholipid catabolic process|phosphatidylethanolamine acyl-chain remodeling|lysophospholipase activity|IRE1-mediated unfolded protein response|glycerophospholipid biosynthetic process|phospholipase A2 activity|long-chain fatty acid metabolic process|calcium ion binding|arachidonic acid metabolic process|cellular biogenic amine metabolic process|phosphatidylserine acyl-chain remodeling|carboxylic acid metabolic process|phosphatidylcholine acyl-chain remodeling|second-messenger-mediated signaling|glycerophospholipid metabolic process|phosphatidic acid biosynthetic process|calcium-dependent phospholipase A2 activity|phosphatidic acid metabolic process|monocarboxylic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|phosphatidylglycerol acyl-chain remodeling - - - - 15:41837775-41848147 13 4 8 1 4 3 0.153748444875538 0.0429943501615579 0.0853075432158014 0.0105916725465327 0.0388123503828028 0.0332481585241856 0.0940167794176324 0.0275507271511737 1.77082786468048 0.00960049463449958 0.0401982001147757 UP ENSG00000279344 RP11-44F14.7 - - - - - - - 16:53478957-53481550 8 5 17 24 23 28 0.218145144019013 0.123927114515504 0.417962031521689 0.58638255372089 0.514600239379635 0.715579190758409 0.253344763352069 0.605520661286311 -1.25707417911376 0.00961315804477174 0.0402396572677696 DOWN ENSG00000233837 EIF3LP2 eukaryotic translation initiation factor 3 subunit L pseudogene 2 [Source:HGNC Symbol;Acc:HGNC:24657] - - - - - - 10:42566677-42567483 3 2 5 12 10 11 0.262991102006126 0.159324168721362 0.395113860974843 0.942466209767059 0.719206679613124 0.903610552546841 0.27247637723411 0.855094480642341 -1.64995267568801 0.00965250375186677 0.0403763271694312 DOWN ENSG00000259673 IQCH-AS1 IQCH antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:44104] - - - - - - 15:67403619-67521844 25 15 24 67 38 41 0.232566868112503 0.126820088880052 0.201289650127221 0.558437247386614 0.290041123964027 0.357452412445877 0.186892202373259 0.401976927932173 -1.10490632077287 0.00968554256540949 0.0405031780008033 DOWN ENSG00000272745 RP5-1007H16.1 - - - - - - - 7:7619872-7620543 3 2 10 0 1 1 0.315824135891286 0.191331256187707 0.949078154712999 0 0.086403612476715 0.0986395020501757 0.485411182263997 0.0616810381756302 2.97630839069503 0.00969401233199565 0.0405329193500557 UP ENSG00000123572 NRK Nik related kinase [Source:HGNC Symbol;Acc:HGNC:25391] GO:0032502|GO:0040007|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:0051716|GO:0097159|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0044702|GO:0071704|GO:0043167|GO:0044237|GO:0003006|GO:0023051|GO:0040008|GO:0009893|GO:0031224|GO:0050793|GO:0048589|GO:0005622|GO:0016740|GO:0048856|GO:0019222|GO:0051726|GO:0042127|GO:0007049|GO:0001890|GO:0009888|GO:0010941|GO:0007275|GO:0048513|GO:0043168|GO:0001882|GO:0016772|GO:0031325|GO:0033554|GO:0048608|GO:0005737|GO:0090214|GO:0009966|GO:0048568|GO:0010646|GO:0001892|GO:0043085|GO:0007154|GO:0007165|GO:0048638|GO:0008219|GO:0008285|GO:0050790|GO:0000166|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0031323|GO:0007567|GO:0000165|GO:1902533|GO:0032268|GO:0035639|GO:0043412|GO:0061458|GO:0060712|GO:0060721|GO:0001883|GO:0009790|GO:0051347|GO:0036211|GO:0000278|GO:0032549|GO:0031098|GO:0007346|GO:0051247|GO:0016301|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0017076|GO:0051246|GO:1902531|GO:0016773|GO:0043067|GO:0045995|GO:0070304|GO:0009792|GO:0031401|GO:0043408|GO:0005524|GO:0030554|GO:0016310|GO:0043410|GO:0032872|GO:0042981|GO:0004672|GO:0006464|GO:0051403|GO:0043549|GO:0006915|GO:0033674|GO:0000186|GO:0045859|GO:0045860|GO:0046328|GO:0006468|GO:0043405|GO:0042325|GO:0007254|GO:0001932|GO:0004674|GO:0043009|GO:0032874|GO:0001934|GO:0042327|GO:0046330|GO:0007256|GO:0071900|GO:0043506|GO:0001701|GO:0032147 developmental process|growth|reproduction|signaling|cell|membrane|cellular process|reproductive process|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|cellular response to stimulus|organic cyclic compound binding|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|single organism reproductive process|organic substance metabolic process|ion binding|cellular metabolic process|developmental process involved in reproduction|regulation of signaling|regulation of growth|positive regulation of metabolic process|intrinsic component of membrane|regulation of developmental process|developmental growth|intracellular|transferase activity|anatomical structure development|regulation of metabolic process|regulation of cell cycle|regulation of cell proliferation|cell cycle|placenta development|tissue development|regulation of cell death|multicellular organism development|animal organ development|anion binding|nucleoside binding|transferase activity, transferring phosphorus-containing groups|positive regulation of cellular metabolic process|cellular response to stress|reproductive structure development|cytoplasm|spongiotrophoblast layer developmental growth|regulation of signal transduction|embryonic organ development|regulation of cell communication|embryonic placenta development|positive regulation of catalytic activity|cell communication|signal transduction|regulation of developmental growth|cell death|negative regulation of cell proliferation|regulation of catalytic activity|nucleotide binding|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|regulation of cellular metabolic process|parturition|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|purine ribonucleoside triphosphate binding|macromolecule modification|reproductive system development|spongiotrophoblast layer development|regulation of spongiotrophoblast cell proliferation|purine nucleoside binding|embryo development|positive regulation of transferase activity|protein modification process|mitotic cell cycle|ribonucleoside binding|stress-activated protein kinase signaling cascade|regulation of mitotic cell cycle|positive regulation of protein metabolic process|kinase activity|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|purine nucleotide binding|regulation of protein metabolic process|regulation of intracellular signal transduction|phosphotransferase activity, alcohol group as acceptor|regulation of programmed cell death|regulation of embryonic development|positive regulation of stress-activated protein kinase signaling cascade|embryo development ending in birth or egg hatching|positive regulation of protein modification process|regulation of MAPK cascade|ATP binding|adenyl nucleotide binding|phosphorylation|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|regulation of apoptotic process|protein kinase activity|cellular protein modification process|stress-activated MAPK cascade|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|activation of MAPKK activity|regulation of protein kinase activity|positive regulation of protein kinase activity|regulation of JNK cascade|protein phosphorylation|regulation of MAP kinase activity|regulation of phosphorylation|JNK cascade|regulation of protein phosphorylation|protein serine/threonine kinase activity|chordate embryonic development|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|positive regulation of phosphorylation|positive regulation of JNK cascade|activation of JNKK activity|regulation of protein serine/threonine kinase activity|regulation of JUN kinase activity|in utero embryonic development|activation of protein kinase activity - - - - X:105822543-105958610 10 2 8 14 20 27 0.0609351851724372 0.0110763787179651 0.043954549963276 0.0764414142398075 0.0999949568872028 0.154197680517711 0.0386553712845594 0.11021135054824 -1.51153201299526 0.00970486176192822 0.0405726009019192 DOWN ENSG00000134827 TCN1 transcobalamin 1 [Source:HGNC Symbol;Acc:HGNC:11652] GO:0009987|GO:0005576|GO:0008152|GO:0005488|GO:0036094|GO:0097159|GO:0006807|GO:0071704|GO:0044237|GO:0005615|GO:0006725|GO:0006810|GO:1901360|GO:0044281|GO:0046483|GO:0019842|GO:0009235|GO:0031419|GO:0006811|GO:0051180|GO:0006766|GO:0006812|GO:0015889|GO:0006767|GO:0030001|GO:0006824 cellular process|extracellular region|metabolic process|binding|small molecule binding|organic cyclic compound binding|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|extracellular space|cellular aromatic compound metabolic process|transport|organic cyclic compound metabolic process|small molecule metabolic process|heterocycle metabolic process|vitamin binding|cobalamin metabolic process|cobalamin binding|ion transport|vitamin transport|vitamin metabolic process|cation transport|cobalamin transport|water-soluble vitamin metabolic process|metal ion transport|cobalt ion transport - - - - 11:59852800-59866575 33 24 23 15 18 9 0.949291162550953 0.62744825128006 0.596527784362563 0.386612740950182 0.424836570039397 0.242636122468428 0.724422399397859 0.351361811152669 1.04387375953524 0.00970685268734757 0.0405752422470001 UP ENSG00000150636 CCDC102B coiled-coil domain containing 102B [Source:HGNC Symbol;Acc:HGNC:26295] GO:0005488|GO:0005515 binding|protein binding - - - - 18:68715209-69055189 11 13 15 40 30 21 0.0898294069388437 0.0964864178810636 0.110440707200858 0.292677209196645 0.201009149156597 0.160718273658841 0.0989188440069218 0.218134877337361 -1.14090317408603 0.00973960434990271 0.0406950522410071 DOWN ENSG00000275084 SNORD91B small nucleolar RNA, C/D box 91B [Source:HGNC Symbol;Acc:HGNC:32753] - - - - - - 17:2329016-2329237 3 2 6 1 0 0 0.669507316463546 0.405598120372678 1.20715555829742 0.199838465302246 0 0 0.760753665044548 0.0666128217674153 3.5135575772286 0.00976756501823705 0.040783340706916 UP ENSG00000278139 PIK3R3 phosphoinositide-3-kinase regulatory subunit 3 [Source:EntrezGene;Acc:8503] GO:0032991|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0051716|GO:0019898|GO:0050794|GO:0051050|GO:0071704|GO:0044237|GO:0030234|GO:0043234|GO:0019222|GO:0044255|GO:0006810|GO:0019637|GO:1900076|GO:0010243|GO:0005942|GO:0010828|GO:1900078|GO:0006629|GO:0009725|GO:0050790|GO:0019207|GO:0010033|GO:0031323|GO:0046326|GO:1901652|GO:0071417|GO:0035014|GO:0043434|GO:1990234|GO:0006796|GO:0051174|GO:0019216|GO:2001273|GO:0071310|GO:2001275|GO:0008643|GO:0032870|GO:0006644|GO:0010827|GO:1901653|GO:0043550|GO:0046324|GO:0016310|GO:0071375|GO:1903725|GO:0032868|GO:0043549|GO:0043551|GO:0008645|GO:0042325|GO:0032869|GO:0015758|GO:0046323 macromolecular complex|membrane|cellular process|metabolic process|response to stimulus|cellular response to stimulus|extrinsic component of membrane|regulation of cellular process|positive regulation of transport|organic substance metabolic process|cellular metabolic process|enzyme regulator activity|protein complex|regulation of metabolic process|cellular lipid metabolic process|transport|organophosphate metabolic process|regulation of cellular response to insulin stimulus|response to organonitrogen compound|phosphatidylinositol 3-kinase complex|positive regulation of glucose transport|positive regulation of cellular response to insulin stimulus|lipid metabolic process|response to hormone|regulation of catalytic activity|kinase regulator activity|response to organic substance|regulation of cellular metabolic process|positive regulation of glucose import|response to peptide|cellular response to organonitrogen compound|phosphatidylinositol 3-kinase regulator activity|response to peptide hormone|transferase complex|phosphate-containing compound metabolic process|regulation of phosphorus metabolic process|regulation of lipid metabolic process|regulation of glucose import in response to insulin stimulus|cellular response to organic substance|positive regulation of glucose import in response to insulin stimulus|carbohydrate transport|cellular response to hormone stimulus|phospholipid metabolic process|regulation of glucose transport|cellular response to peptide|regulation of lipid kinase activity|regulation of glucose import|phosphorylation|cellular response to peptide hormone stimulus|regulation of phospholipid metabolic process|response to insulin|regulation of kinase activity|regulation of phosphatidylinositol 3-kinase activity|hexose transport|regulation of phosphorylation|cellular response to insulin stimulus|glucose transport|glucose import - - - - 1:46043661-46176488 0 0 0 1 0 13 0 0 0 0.0407912385710316 0 0.554961830915093 0 0.198584356495375 -Inf 0.00979373483509607 0.0408697455642938 DOWN ENSG00000278467 RP11-504P24.9 - - - - - - - 1:223994262-223995196 5 7 10 15 16 29 0.617279136501351 0.785412808396782 1.11305500866865 1.65912867364136 1.62060173107697 3.35514514171908 0.838582317855594 2.2116251821458 -1.39908258850285 0.0098093020296361 0.0409175496426933 DOWN ENSG00000232656 IDI2-AS1 IDI2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:30885] - - - - - - 10:1022666-1044201 10 19 10 6 5 5 0.226492356542315 0.39112685371764 0.204220467488676 0.121769169273458 0.0929234374716285 0.10614769248767 0.273946559249544 0.106946766410919 1.3570016210497 0.00982002635637334 0.0409508404586073 UP ENSG00000283027 CAPS calcyphosine [Source:HGNC Symbol;Acc:HGNC:1487] GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0009056|GO:0043167|GO:0006914|GO:0016043|GO:0043227|GO:0071944|GO:0005622|GO:0005886|GO:0031982|GO:0033554|GO:0043231|GO:0043169|GO:0005737|GO:0007154|GO:0007165|GO:0000422|GO:0070062|GO:0016236|GO:0006996|GO:1903008|GO:0046872|GO:0000423|GO:0007005|GO:0035556|GO:0005634|GO:0005509|GO:0098779 signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|catabolic process|ion binding|autophagy|cellular component organization|membrane-bounded organelle|cell periphery|intracellular|plasma membrane|vesicle|cellular response to stress|intracellular membrane-bounded organelle|cation binding|cytoplasm|cell communication|signal transduction|mitophagy|extracellular exosome|macroautophagy|organelle organization|organelle disassembly|metal ion binding|macromitophagy|mitochondrion organization|intracellular signal transduction|nucleus|calcium ion binding|mitophagy in response to mitochondrial depolarization - - - - 19:5914407-5915322 12 12 4 38 25 18 1.73592845874617 1.57760250500784 0.521701856823833 4.92517030848195 2.96716023470459 2.44025449959045 1.27841094019261 3.444195014259 -1.4298151725802 0.00983205340260337 0.0409952684750448 DOWN ENSG00000196366 C9orf163 chromosome 9 open reading frame 163 [Source:HGNC Symbol;Acc:HGNC:26718] - - - - - - 9:136483495-136486067 7 12 10 24 23 23 0.0962425794191651 0.149941229338938 0.123961228370677 0.295641660709813 0.259450538571579 0.296362234001695 0.123381679042927 0.283818144427696 -1.20183863903454 0.00983966440675739 0.0410155461043473 DOWN ENSG00000182366 FAM87A family with sequence similarity 87 member A [Source:HGNC Symbol;Acc:HGNC:27233] - - - - - - 8:375931-383174 0 0 0 4 1 3 0 0 0 0.0354033529433513 0.0081082568893105 0.0277694785830407 0 0.0237603628052342 -Inf 0.00985101632590066 0.0410506294370048 DOWN ENSG00000248445 SEMA6A-AS1 SEMA6A antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:51110] - - - - - - 5:116447547-116508276 0 0 0 4 1 3 0 0 0 0.0695346709893963 0.0159251858432124 0.0545412057414027 0 0.0466670208580038 -Inf 0.0098522060667294 0.0410506294370048 DOWN ENSG00000273061 CDC37L1-AS1 CDC37L1 antisense RNA 1 (head to head) [Source:HGNC Symbol;Acc:HGNC:49735] - - - - - - 9:4676600-4679502 0 0 0 4 1 3 0 0 0 0.363214055053494 0.0831851398056625 0.284895753772427 0 0.243764982877195 -Inf 0.0098495074145543 0.0410506294370048 DOWN ENSG00000232593 KANTR KDM5C adjacent non-coding transcript [Source:HGNC Symbol;Acc:HGNC:49510] - - - - - - X:53094145-53167014 3 5 12 14 21 21 0.0633912244082867 0.0960176030624902 0.228595168447002 0.265033433839811 0.364039631759559 0.41581292904208 0.129334665305926 0.34829533154715 -1.42920212599428 0.00985533641854246 0.0410522134001907 DOWN ENSG00000169184 MN1 meningioma (disrupted in balanced translocation) 1 [Source:HGNC Symbol;Acc:HGNC:7180] GO:0001503|GO:0001957 ossification|intramembranous ossification - - - - 22:27748277-27801498 0 1 6 10 10 7 0 0.00736574974083135 0.0438236729249062 0.0725845769661414 0.066468139080141 0.0531459842412309 0.0170631408885792 0.0640662334291711 -1.90868093989716 0.00987292614898812 0.0411140099388885 DOWN ENSG00000272841 RP3-428L16.2 - - - - - - - 6:160990318-160992342 4 10 8 16 35 13 0.139720618169215 0.317468158415158 0.251962674554918 0.500755320245585 1.00313142973745 0.425607764647476 0.23638381704643 0.64316483821017 -1.44405726532956 0.00987680321236553 0.0411244188426723 DOWN ENSG00000165091 TMC1 transmembrane channel like 1 [Source:HGNC Symbol;Acc:HGNC:16513] GO:0032502|GO:0005215|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0042995|GO:0022857|GO:0051606|GO:0032420|GO:0009628|GO:0009986|GO:0071944|GO:0032426|GO:0009605|GO:0031224|GO:0005886|GO:0048856|GO:0009897|GO:0009888|GO:0048468|GO:0006810|GO:0009612|GO:0048839|GO:0007275|GO:0048513|GO:0032421|GO:0050877|GO:0009582|GO:0060004|GO:0007423|GO:0022891|GO:0050906|GO:0055085|GO:0048869|GO:0016021|GO:0060113|GO:0043583|GO:0002064|GO:0015267|GO:0006811|GO:0015075|GO:0007600|GO:0060005|GO:0050982|GO:0060429|GO:0050974|GO:0007399|GO:0030154|GO:0034220|GO:0050910|GO:0048666|GO:0030182|GO:0098655|GO:0005216|GO:0050954|GO:0030855|GO:0002066|GO:0006812|GO:0008544|GO:0042491|GO:0060119|GO:0022008|GO:0008324|GO:0007605|GO:0005244|GO:0048699|GO:0035315|GO:0060117|GO:0022890|GO:0030001|GO:0042490|GO:0005261|GO:0009913|GO:0005262|GO:0070588|GO:0022843|GO:0060563|GO:0046873|GO:0006816|GO:0015085|GO:0005245 developmental process|transporter activity|cell|membrane|cellular process|response to stimulus|cell projection|transmembrane transporter activity|detection of stimulus|stereocilium|response to abiotic stimulus|cell surface|cell periphery|stereocilium tip|response to external stimulus|intrinsic component of membrane|plasma membrane|anatomical structure development|external side of plasma membrane|tissue development|cell development|transport|response to mechanical stimulus|inner ear development|multicellular organism development|animal organ development|stereocilium bundle|neurological system process|detection of abiotic stimulus|reflex|sensory organ development|substrate-specific transmembrane transporter activity|detection of stimulus involved in sensory perception|transmembrane transport|cellular developmental process|integral component of membrane|inner ear receptor cell differentiation|ear development|epithelial cell development|channel activity|ion transport|ion transmembrane transporter activity|sensory perception|vestibular reflex|detection of mechanical stimulus|epithelium development|detection of mechanical stimulus involved in sensory perception|nervous system development|cell differentiation|ion transmembrane transport|detection of mechanical stimulus involved in sensory perception of sound|neuron development|neuron differentiation|cation transmembrane transport|ion channel activity|sensory perception of mechanical stimulus|epithelial cell differentiation|columnar/cuboidal epithelial cell development|cation transport|epidermis development|auditory receptor cell differentiation|inner ear receptor cell development|neurogenesis|cation transmembrane transporter activity|sensory perception of sound|voltage-gated ion channel activity|generation of neurons|hair cell differentiation|auditory receptor cell development|inorganic cation transmembrane transporter activity|metal ion transport|mechanoreceptor differentiation|cation channel activity|epidermal cell differentiation|calcium channel activity|calcium ion transmembrane transport|voltage-gated cation channel activity|neuroepithelial cell differentiation|metal ion transmembrane transporter activity|calcium ion transport|calcium ion transmembrane transporter activity|voltage-gated calcium channel activity - - - - 9:72521801-72836351 3 1 15 19 10 47 0.0386160515500262 0.0117026431471869 0.174060663350406 0.219105556845676 0.105604037563281 0.566931065002759 0.0747931193492064 0.297213553137239 -1.99052244575211 0.00988742180174296 0.0411571514876233 DOWN ENSG00000233672 RNASEH2B-AS1 RNASEH2B antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:39967] - - - - - - 13:50862172-50910764 1 1 5 11 8 7 0.0115594076155854 0.0105059991403037 0.0520837774921102 0.11387737987082 0.0758463666494642 0.0758037788948756 0.0247163947493331 0.0885091751383866 -1.84035869699416 0.00991230207407623 0.0412492146807181 DOWN ENSG00000260936 FTO-IT1 FTO intronic transcript 1 [Source:HGNC Symbol;Acc:HGNC:43758] - - - - - - 16:54039393-54040726 2 1 1 7 8 4 0.115672220683835 0.0525901281577591 0.052121568127428 0.36274236234 0.379665949818495 0.216797204833093 0.0734613056563407 0.319735172330529 -2.12182101290761 0.00994450498491103 0.0413601632515372 DOWN ENSG00000267397 RP11-873E20.1 - - - - - - - 18:35716370-35717978 0 0 1 2 3 8 0 0 0.0396175747792694 0.0787829118792228 0.108223468865211 0.329618694699905 0.0132058582597565 0.172208358481446 -3.70490519693973 0.00997863152734678 0.0414732097476557 DOWN ENSG00000130052 STARD8 StAR related lipid transfer domain containing 8 [Source:HGNC Symbol;Acc:HGNC:19161] GO:0023052|GO:0005623|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0030055|GO:0050794|GO:0023051|GO:0008289|GO:0009893|GO:0030234|GO:0005622|GO:0019222|GO:0008047|GO:0005924|GO:0005912|GO:0005737|GO:0009966|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0050790|GO:0005829|GO:0005096|GO:0051345|GO:0030695|GO:0035556|GO:1902531|GO:0005925|GO:0043087|GO:0043547|GO:0051056|GO:0007264 signaling|cell|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell-substrate junction|regulation of cellular process|regulation of signaling|lipid binding|positive regulation of metabolic process|enzyme regulator activity|intracellular|regulation of metabolic process|enzyme activator activity|cell-substrate adherens junction|adherens junction|cytoplasm|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|regulation of catalytic activity|cytosol|GTPase activator activity|positive regulation of hydrolase activity|GTPase regulator activity|intracellular signal transduction|regulation of intracellular signal transduction|focal adhesion|regulation of GTPase activity|positive regulation of GTPase activity|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction - - - - X:68647666-68725842 10 5 20 2 4 6 0.0668938556347315 0.0304016394035575 0.120631836574075 0.0119880561011603 0.0219535339171121 0.0376191591655675 0.072642443870788 0.02385358306128 1.60660674864941 0.0099953286211519 0.041536823587955 UP ENSG00000279909 AC110615.1 - GO:0016020|GO:0031224|GO:0016021 membrane|intrinsic component of membrane|integral component of membrane - - - - 4:75949920-75957413 9 0 2 0 0 0 0.563893000007028 0 0.112981491579652 0 0 0 0.225624830528893 0 Inf 0.00999760258240311 0.0415404909526879 UP ENSG00000248254 AC092597.3 - - - - - - - 4:47556731-47560259 0 2 2 5 6 8 0 0.213934449514374 0.212239773699546 0.527241603873795 0.579376042361589 0.882456705111725 0.14205807440464 0.66302478378237 -2.22258196424999 0.0100085276377526 0.0415743125222577 DOWN ENSG00000274092 CTD-3203P2.3 - - - - - - - 16:27313387-27314101 1 2 2 9 6 6 0.0989743963952641 0.179824621200194 0.178400145445352 0.797756103993692 0.487000002041 0.556342641981413 0.152399721013603 0.613699582672035 -2.00967234061105 0.0100433441235155 0.0416957301437119 DOWN ENSG00000270087 RP11-399K21.11 - - - - - - - 10:75279726-75401246 0 1 1 5 5 4 0 0.0785320228778258 0.0778323294503596 0.38690134789762 0.354334426402803 0.323739904164679 0.0521214507760618 0.354991892821701 -2.76783693092318 0.0101445279746867 0.0420865394880901 DOWN ENSG00000274810 NPHP3-ACAD11 NPHP3-ACAD11 readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:48351] GO:0032991|GO:0005623|GO:0008152|GO:0005488|GO:0003824|GO:0043229|GO:0016787|GO:0005622|GO:0005515|GO:0043234|GO:0016817|GO:0005875|GO:0005871|GO:0016818|GO:0005856|GO:0015630|GO:0016462|GO:0017111|GO:0003774|GO:0003777 macromolecular complex|cell|metabolic process|binding|catalytic activity|intracellular organelle|hydrolase activity|intracellular|protein binding|protein complex|hydrolase activity, acting on acid anhydrides|microtubule associated complex|kinesin complex|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|cytoskeleton|microtubule cytoskeleton|pyrophosphatase activity|nucleoside-triphosphatase activity|motor activity|microtubule motor activity - - - - 3:132558142-132722459 10 9 22 5 8 3 0.0799972437776126 0.0654395095419018 0.158680207597145 0.0358371639819216 0.0525143018127143 0.0224900742064187 0.101372320305553 0.0369471800003515 1.45612761873461 0.0101704779562664 0.0421766146556991 UP ENSG00000133519 ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:26461] - - - - - - 22:23390606-23402726 25 12 68 14 9 18 0.344054176094839 0.150087086565921 0.843730357795534 0.172632672469978 0.101621899389774 0.232156507840414 0.445957206818765 0.168803693233389 1.40155880967128 0.0102561877491561 0.0424789440986831 UP ENSG00000230929 RP11-395C3.1 - - - - - - - 5:126628019-126628319 4 7 6 3 0 1 0.939980902965649 1.49515461532012 1.27132329561555 0.631596341244124 0 0.220218423181788 1.23548627130044 0.283938254808637 2.12142983896125 0.010320231145991 0.042720490936275 UP ENSG00000174500 GCSAM germinal center-associated, signaling and motility [Source:HGNC Symbol;Acc:HGNC:20253] GO:0040011|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0050896|GO:0005488|GO:0051716|GO:0040013|GO:0002683|GO:0048523|GO:0050794|GO:0040012|GO:0050900|GO:0006955|GO:0048870|GO:0023051|GO:0071944|GO:0002684|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0002757|GO:0002685|GO:0019899|GO:0005737|GO:0006928|GO:0009966|GO:0010646|GO:0050776|GO:0007154|GO:0051270|GO:0016477|GO:0007165|GO:0050778|GO:0002686|GO:0008092|GO:0051271|GO:0072676|GO:2000145|GO:2000146|GO:0007166|GO:0017022|GO:0003779|GO:0030334|GO:2000402|GO:0002429|GO:0002764|GO:0030336|GO:0019900|GO:2000401|GO:0045159|GO:0002768|GO:0050855|GO:0019901|GO:0050851|GO:0050853 locomotion|immune system process|signaling|cell|membrane|cellular process|response to stimulus|binding|cellular response to stimulus|negative regulation of locomotion|negative regulation of immune system process|negative regulation of cellular process|regulation of cellular process|regulation of locomotion|leukocyte migration|immune response|cell motility|regulation of signaling|cell periphery|positive regulation of immune system process|intracellular|regulation of immune system process|protein binding|plasma membrane|immune response-activating signal transduction|regulation of leukocyte migration|enzyme binding|cytoplasm|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|regulation of immune response|cell communication|regulation of cellular component movement|cell migration|signal transduction|positive regulation of immune response|negative regulation of leukocyte migration|cytoskeletal protein binding|negative regulation of cellular component movement|lymphocyte migration|regulation of cell motility|negative regulation of cell motility|cell surface receptor signaling pathway|myosin binding|actin binding|regulation of cell migration|negative regulation of lymphocyte migration|immune response-activating cell surface receptor signaling pathway|immune response-regulating signaling pathway|negative regulation of cell migration|kinase binding|regulation of lymphocyte migration|myosin II binding|immune response-regulating cell surface receptor signaling pathway|regulation of B cell receptor signaling pathway|protein kinase binding|antigen receptor-mediated signaling pathway|B cell receptor signaling pathway - - - - 3:112120841-112133305 4 9 22 28 24 36 0.0394938933267253 0.0807671891917218 0.195847347232546 0.247710741873161 0.194435545580001 0.333133570714609 0.105369476583664 0.258426619389257 -1.29429767557356 0.0103537593441975 0.0428473983173927 DOWN ENSG00000257639 CTB-31N19.2 - - - - - - - 16:21532945-21550373 1 0 3 6 4 10 0.122858842747593 0 0.332119412870263 0.660217214654528 0.403015047985318 1.15091661549928 0.151659418539285 0.738049626046375 -2.28288272879749 0.0103584624141934 0.0428549801709159 DOWN ENSG00000145362 ANK2 ankyrin 2, neuronal [Source:HGNC Symbol;Acc:HGNC:493] GO:0040011|GO:0032502|GO:0045202|GO:0005198|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0060090|GO:0005200|GO:0051716|GO:0042995|GO:0048523|GO:0098900|GO:0050794|GO:0043229|GO:0051050|GO:0071704|GO:0051641|GO:0045177|GO:0023051|GO:0005911|GO:0009653|GO:0016043|GO:0071944|GO:0009605|GO:0009893|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0097060|GO:0048646|GO:0019222|GO:0030017|GO:0007507|GO:0060341|GO:0030018|GO:0051282|GO:0042391|GO:0006935|GO:0048468|GO:0016323|GO:0044325|GO:0006810|GO:0016324|GO:0007275|GO:0048513|GO:0044291|GO:0043270|GO:0045211|GO:0022607|GO:0061061|GO:0030315|GO:0019899|GO:0005737|GO:0032970|GO:0003012|GO:0007267|GO:0006928|GO:0042592|GO:0043005|GO:0098901|GO:0031430|GO:0031672|GO:0042383|GO:0019725|GO:0030674|GO:0031674|GO:0010646|GO:0008104|GO:0007154|GO:0055085|GO:0061024|GO:0051270|GO:0007165|GO:0031647|GO:0003279|GO:0051649|GO:0008092|GO:2000021|GO:0071804|GO:0030030|GO:0043034|GO:0051238|GO:0002027|GO:0048869|GO:0030029|GO:1903779|GO:0010033|GO:0098857|GO:0010256|GO:0032411|GO:0003013|GO:0003205|GO:0000902|GO:0005829|GO:0031175|GO:0086009|GO:0010468|GO:0006936|GO:0045216|GO:0033292|GO:0051597|GO:0086019|GO:0051899|GO:0072358|GO:0061337|GO:0050821|GO:0042692|GO:0048878|GO:0030048|GO:0032386|GO:0051117|GO:0030913|GO:0014704|GO:0000904|GO:0090257|GO:0001508|GO:0051208|GO:0010628|GO:0034767|GO:0007009|GO:0086091|GO:0098907|GO:0046907|GO:0006811|GO:0051209|GO:0055082|GO:0034329|GO:0051279|GO:0043292|GO:0072657|GO:0034765|GO:0055001|GO:0003283|GO:0043269|GO:0034613|GO:0043268|GO:0019900|GO:0035556|GO:0098910|GO:0032288|GO:0010467|GO:0032990|GO:0007399|GO:0097485|GO:0032414|GO:0060306|GO:0071805|GO:0010522|GO:0030154|GO:0048858|GO:0045121|GO:0051928|GO:0072359|GO:0008015|GO:0005856|GO:0022898|GO:0086065|GO:0008366|GO:0030507|GO:0034220|GO:0048666|GO:0006941|GO:0030182|GO:0008016|GO:0007411|GO:0098655|GO:0070252|GO:0086001|GO:0033365|GO:0030016|GO:1901379|GO:0006937|GO:0086010|GO:0072659|GO:0060047|GO:0006812|GO:1901021|GO:0010880|GO:0014808|GO:0060402|GO:0086004|GO:0034394|GO:0061564|GO:0016482|GO:0032412|GO:2001259|GO:0086066|GO:0050801|GO:0042552|GO:1904427|GO:0019901|GO:0022008|GO:0048667|GO:0086070|GO:0019932|GO:0048812|GO:1901381|GO:0007043|GO:1990778|GO:0006873|GO:0090279|GO:1901018|GO:0070296|GO:0086003|GO:0070972|GO:0060307|GO:1903169|GO:1901016|GO:0010881|GO:0043266|GO:0007409|GO:0036371|GO:0048699|GO:0006942|GO:0086002|GO:0060048|GO:0086015|GO:0036309|GO:0055117|GO:1901019|GO:0030001|GO:0019722|GO:0051924|GO:2001257|GO:0086012|GO:0030003|GO:0015672|GO:0086014|GO:0006813|GO:0070588|GO:0010882|GO:0055065|GO:0097553|GO:0006875|GO:0086046|GO:0086005|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0070509|GO:0060401|GO:0007204 locomotion|developmental process|synapse|structural molecule activity|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|binding, bridging|structural constituent of cytoskeleton|cellular response to stimulus|cell projection|negative regulation of cellular process|regulation of action potential|regulation of cellular process|intracellular organelle|positive regulation of transport|organic substance metabolic process|cellular localization|apical part of cell|regulation of signaling|cell-cell junction|anatomical structure morphogenesis|cellular component organization|cell periphery|response to external stimulus|positive regulation of metabolic process|intracellular|protein binding|plasma membrane|anatomical structure development|synaptic membrane|anatomical structure formation involved in morphogenesis|regulation of metabolic process|sarcomere|heart development|regulation of cellular localization|Z disc|regulation of sequestering of calcium ion|regulation of membrane potential|chemotaxis|cell development|basolateral plasma membrane|ion channel binding|transport|apical plasma membrane|multicellular organism development|animal organ development|cell-cell contact zone|positive regulation of ion transport|postsynaptic membrane|cellular component assembly|muscle structure development|T-tubule|enzyme binding|cytoplasm|regulation of actin filament-based process|muscle system process|cell-cell signaling|movement of cell or subcellular component|homeostatic process|neuron projection|regulation of cardiac muscle cell action potential|M band|A band|sarcolemma|cellular homeostasis|protein binding, bridging|I band|regulation of cell communication|protein localization|cell communication|transmembrane transport|membrane organization|regulation of cellular component movement|signal transduction|regulation of protein stability|cardiac septum development|establishment of localization in cell|cytoskeletal protein binding|regulation of ion homeostasis|cellular potassium ion transport|cell projection organization|costamere|sequestering of metal ion|regulation of heart rate|cellular developmental process|actin filament-based process|regulation of cardiac conduction|response to organic substance|membrane microdomain|endomembrane system organization|positive regulation of transporter activity|circulatory system process|cardiac chamber development|cell morphogenesis|cytosol|neuron projection development|membrane repolarization|regulation of gene expression|muscle contraction|cell-cell junction organization|T-tubule organization|response to methylmercury|cell-cell signaling involved in cardiac conduction|membrane depolarization|cardiovascular system development|cardiac conduction|protein stabilization|muscle cell differentiation|chemical homeostasis|actin filament-based movement|regulation of intracellular transport|ATPase binding|paranodal junction assembly|intercalated disc|cell morphogenesis involved in differentiation|regulation of muscle system process|action potential|sequestering of calcium ion|positive regulation of gene expression|positive regulation of ion transmembrane transport|plasma membrane organization|regulation of heart rate by cardiac conduction|regulation of SA node cell action potential|intracellular transport|ion transport|release of sequestered calcium ion into cytosol|cellular chemical homeostasis|cell junction assembly|regulation of release of sequestered calcium ion into cytosol|contractile fiber|protein localization to membrane|regulation of ion transmembrane transport|muscle cell development|atrial septum development|regulation of ion transport|cellular protein localization|positive regulation of potassium ion transport|kinase binding|intracellular signal transduction|regulation of atrial cardiac muscle cell action potential|myelin assembly|gene expression|cell part morphogenesis|nervous system development|neuron projection guidance|positive regulation of ion transmembrane transporter activity|regulation of membrane repolarization|potassium ion transmembrane transport|regulation of calcium ion transport into cytosol|cell differentiation|cell projection morphogenesis|membrane raft|positive regulation of calcium ion transport|circulatory system development|blood circulation|cytoskeleton|regulation of transmembrane transporter activity|cell communication involved in cardiac conduction|axon ensheathment|spectrin binding|ion transmembrane transport|neuron development|striated muscle contraction|neuron differentiation|regulation of heart contraction|axon guidance|cation transmembrane transport|actin-mediated cell contraction|cardiac muscle cell action potential|protein localization to organelle|myofibril|regulation of potassium ion transmembrane transport|regulation of muscle contraction|membrane depolarization during action potential|protein localization to plasma membrane|heart contraction|cation transport|positive regulation of calcium ion transmembrane transporter activity|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|calcium ion transport into cytosol|regulation of cardiac muscle cell contraction|protein localization to cell surface|axon development|cytosolic transport|regulation of ion transmembrane transporter activity|positive regulation of cation channel activity|atrial cardiac muscle cell to AV node cell communication|ion homeostasis|myelination|positive regulation of calcium ion transmembrane transport|protein kinase binding|neurogenesis|cell morphogenesis involved in neuron differentiation|SA node cell to atrial cardiac muscle cell communication|second-messenger-mediated signaling|neuron projection morphogenesis|positive regulation of potassium ion transmembrane transport|cell-cell junction assembly|protein localization to cell periphery|cellular ion homeostasis|regulation of calcium ion import|positive regulation of potassium ion transmembrane transporter activity|sarcoplasmic reticulum calcium ion transport|cardiac muscle cell contraction|protein localization to endoplasmic reticulum|regulation of ventricular cardiac muscle cell membrane repolarization|regulation of calcium ion transmembrane transport|regulation of potassium ion transmembrane transporter activity|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|regulation of potassium ion transport|axonogenesis|protein localization to T-tubule|generation of neurons|regulation of striated muscle contraction|cardiac muscle cell action potential involved in contraction|cardiac muscle contraction|SA node cell action potential|protein localization to M-band|regulation of cardiac muscle contraction|regulation of calcium ion transmembrane transporter activity|metal ion transport|calcium-mediated signaling|regulation of calcium ion transport|regulation of cation channel activity|membrane depolarization during cardiac muscle cell action potential|cellular cation homeostasis|monovalent inorganic cation transport|atrial cardiac muscle cell action potential|potassium ion transport|calcium ion transmembrane transport|regulation of cardiac muscle contraction by calcium ion signaling|metal ion homeostasis|calcium ion transmembrane import into cytosol|cellular metal ion homeostasis|membrane depolarization during SA node cell action potential|ventricular cardiac muscle cell action potential|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|calcium ion import|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K10380 ankyrin[-] hsa05205 Proteoglycans in cancer - Homo sapiens (human) 4:112818109-113383740 4 0 2 6 16 7 0.00816219281654339 0 0.00367978606027657 0.0109706068440171 0.0267887373617328 0.0133876856218102 0.00394732629227332 0.01704900994252 -2.11074027782297 0.010391235114284 0.0429786551817447 DOWN ENSG00000234715 CTB-107G13.1 - - - - - - - 7:103445207-103514007 0 1 0 2 4 6 0 0.0236028354997943 0 0.0465180569591447 0.0851877679411168 0.145976142758426 0.00786761183326477 0.0925606558862292 -3.5564014016358 0.0104118837817157 0.0430402074798312 DOWN ENSG00000260377 RP11-646E18.4 - - - - - - - 3:182739669-182740848 0 0 1 6 4 2 0 0 0.0540209134066479 0.322275521729668 0.196725989525037 0.112348720979183 0.0180069711355493 0.210450077411296 -3.54685060226113 0.010425116168111 0.0430718709621683 DOWN ENSG00000279621 RP11-67A1.4 - - - - - - - 16:68199841-68200981 0 4 5 0 0 0 0 0.225371786429691 0.27945388764829 0 0 0 0.16827522469266 0 Inf 0.0104472538402263 0.0431565402167034 UP ENSG00000262514 RP11-96D1.9 - - - - - - - 16:68199795-68200981 0 4 5 0 0 0 0 0.216637917705373 0.268624166644228 0 0 0 0.161754028116534 0 Inf 0.0104512275151089 0.0431669820470477 UP ENSG00000265303 CTD-2510F5.6 - GO:0009987|GO:0008152|GO:0006807|GO:0071704|GO:0009056|GO:0044237|GO:0006725|GO:1901360|GO:0034641|GO:0046483|GO:0006139|GO:0044265|GO:0019439|GO:0016070|GO:0006401|GO:0016071|GO:0006402|GO:0000956|GO:0000184 cellular process|metabolic process|nitrogen compound metabolic process|organic substance metabolic process|catabolic process|cellular metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|cellular macromolecule catabolic process|aromatic compound catabolic process|RNA metabolic process|RNA catabolic process|mRNA metabolic process|mRNA catabolic process|nuclear-transcribed mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay - - - - 17:59197566-59215226 11 8 11 4 7 0 1.39695210575272 0.923336475103332 1.25947073211307 0.455158726081398 0.729386407618792 0 1.19325310432304 0.394848377900063 1.59552942098954 0.0104548555064209 0.0431759934000122 UP ENSG00000174871 CNIH2 cornichon family AMPA receptor auxiliary protein 2 [Source:HGNC Symbol;Acc:HGNC:28744] GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0030054|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0048523|GO:0050794|GO:0060076|GO:0043229|GO:0042175|GO:0071704|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0023057|GO:0009058|GO:0031224|GO:1902684|GO:0005622|GO:0005789|GO:0005515|GO:0005886|GO:0043234|GO:0012505|GO:0097060|GO:0031090|GO:0060341|GO:0006486|GO:0043198|GO:0050804|GO:0042391|GO:0051640|GO:0006810|GO:0098797|GO:0060627|GO:0031982|GO:0045211|GO:0022607|GO:0051668|GO:0005887|GO:0043231|GO:0030133|GO:0005737|GO:0007267|GO:0032886|GO:0032880|GO:0012506|GO:0043235|GO:0006903|GO:0005975|GO:0006928|GO:0051656|GO:0043005|GO:0009966|GO:0043197|GO:0036477|GO:0030658|GO:0014069|GO:0032387|GO:0010646|GO:0031226|GO:0008104|GO:1902495|GO:0007154|GO:0055085|GO:0061024|GO:0051270|GO:0010970|GO:0007165|GO:0005783|GO:0051649|GO:0051271|GO:0050805|GO:0016021|GO:0044249|GO:0010469|GO:0007017|GO:0019538|GO:0005794|GO:0006996|GO:0016192|GO:0051650|GO:0012507|GO:0008328|GO:0034645|GO:0006900|GO:0016050|GO:0007166|GO:0043412|GO:0005793|GO:0006487|GO:0090114|GO:0044309|GO:0031410|GO:0032386|GO:0048489|GO:0033116|GO:0016023|GO:0009100|GO:0036211|GO:0046907|GO:0048199|GO:0006811|GO:0060632|GO:1902803|GO:0008088|GO:0030425|GO:0007018|GO:0031988|GO:0034765|GO:0070085|GO:0034702|GO:0035418|GO:0006461|GO:0043269|GO:0035556|GO:0030659|GO:1901137|GO:0044267|GO:0000139|GO:0051648|GO:0009059|GO:0072384|GO:0022898|GO:0030134|GO:0034220|GO:0009101|GO:0043413|GO:2000310|GO:0007215|GO:1902513|GO:0047496|GO:0048208|GO:0008089|GO:0018279|GO:0048193|GO:0016482|GO:0097120|GO:0032412|GO:0030135|GO:2000311|GO:1903743|GO:0032281|GO:0006464|GO:0030705|GO:0018193|GO:0043687|GO:0048490|GO:0006888|GO:0007268|GO:0007270|GO:0035249 macromolecular complex|synapse|signaling|cell|membrane|cellular process|metabolic process|cell junction|response to stimulus|binding|cellular response to stimulus|cell projection|negative regulation of cellular process|regulation of cellular process|excitatory synapse|intracellular organelle|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|negative regulation of signaling|biosynthetic process|intrinsic component of membrane|negative regulation of receptor localization to synapse|intracellular|endoplasmic reticulum membrane|protein binding|plasma membrane|protein complex|endomembrane system|synaptic membrane|organelle membrane|regulation of cellular localization|protein glycosylation|dendritic shaft|modulation of synaptic transmission|regulation of membrane potential|organelle localization|transport|plasma membrane protein complex|regulation of vesicle-mediated transport|vesicle|postsynaptic membrane|cellular component assembly|localization within membrane|integral component of plasma membrane|intracellular membrane-bounded organelle|transport vesicle|cytoplasm|cell-cell signaling|regulation of microtubule-based process|regulation of protein localization|vesicle membrane|receptor complex|vesicle targeting|carbohydrate metabolic process|movement of cell or subcellular component|establishment of organelle localization|neuron projection|regulation of signal transduction|dendritic spine|somatodendritic compartment|transport vesicle membrane|postsynaptic density|negative regulation of intracellular transport|regulation of cell communication|intrinsic component of plasma membrane|protein localization|transmembrane transporter complex|cell communication|transmembrane transport|membrane organization|regulation of cellular component movement|establishment of localization by movement along microtubule|signal transduction|endoplasmic reticulum|establishment of localization in cell|negative regulation of cellular component movement|negative regulation of synaptic transmission|integral component of membrane|cellular biosynthetic process|regulation of receptor activity|microtubule-based process|protein metabolic process|Golgi apparatus|organelle organization|vesicle-mediated transport|establishment of vesicle localization|ER to Golgi transport vesicle membrane|ionotropic glutamate receptor complex|cellular macromolecule biosynthetic process|membrane budding|vesicle organization|cell surface receptor signaling pathway|macromolecule modification|endoplasmic reticulum-Golgi intermediate compartment|protein N-linked glycosylation|COPII-coated vesicle budding|neuron spine|cytoplasmic vesicle|regulation of intracellular transport|synaptic vesicle transport|endoplasmic reticulum-Golgi intermediate compartment membrane|cytoplasmic, membrane-bounded vesicle|glycoprotein metabolic process|protein modification process|intracellular transport|vesicle targeting, to, from or within Golgi|ion transport|regulation of microtubule-based movement|regulation of synaptic vesicle transport|axo-dendritic transport|dendrite|microtubule-based movement|membrane-bounded vesicle|regulation of ion transmembrane transport|glycosylation|ion channel complex|protein localization to synapse|protein complex assembly|regulation of ion transport|intracellular signal transduction|cytoplasmic vesicle membrane|carbohydrate derivative biosynthetic process|cellular protein metabolic process|Golgi membrane|vesicle localization|macromolecule biosynthetic process|organelle transport along microtubule|regulation of transmembrane transporter activity|ER to Golgi transport vesicle|ion transmembrane transport|glycoprotein biosynthetic process|macromolecule glycosylation|regulation of N-methyl-D-aspartate selective glutamate receptor activity|glutamate receptor signaling pathway|regulation of organelle transport along microtubule|vesicle transport along microtubule|COPII vesicle coating|anterograde axonal transport|protein N-linked glycosylation via asparagine|Golgi vesicle transport|cytosolic transport|receptor localization to synapse|regulation of ion transmembrane transporter activity|coated vesicle|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|negative regulation of anterograde synaptic vesicle transport|AMPA glutamate receptor complex|cellular protein modification process|cytoskeleton-dependent intracellular transport|peptidyl-amino acid modification|post-translational protein modification|anterograde synaptic vesicle transport|ER to Golgi vesicle-mediated transport|synaptic transmission|neuron-neuron synaptic transmission|synaptic transmission, glutamatergic - - - - 11:66278190-66285301 21 17 16 4 5 14 0.320635487445459 0.235897811353777 0.22025660089519 0.0547212196044332 0.062637577212151 0.200332715041843 0.258929966564809 0.105897170619476 1.28989789769167 0.0104572344423844 0.0431798446809051 UP ENSG00000234945 GTF3C2-AS1 GTF3C2 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:40269] - - - - - - 2:27335535-27342599 1 4 0 8 6 10 0.0121467032994531 0.0441382094603979 0 0.0870317234560037 0.0597674221523026 0.113787842521041 0.018761637586617 0.0868623293764491 -2.21094488466343 0.0105367549962336 0.0434946494160086 DOWN ENSG00000156049 GNA14 guanine nucleotide binding protein (G protein), alpha 14 [Source:HGNC Symbol;Acc:HGNC:4382] GO:0032991|GO:0004871|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0019898|GO:0097159|GO:0044877|GO:0050794|GO:0006950|GO:0043167|GO:0043227|GO:0071944|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0050817|GO:0009898|GO:0098797|GO:0005102|GO:0043168|GO:0001882|GO:0031982|GO:0016817|GO:0043169|GO:0009611|GO:0032403|GO:0031234|GO:0001775|GO:0098562|GO:0019897|GO:0007154|GO:0007165|GO:0070062|GO:0005834|GO:0000166|GO:0050878|GO:0007186|GO:0030168|GO:0046872|GO:0035639|GO:0007596|GO:0001883|GO:0016818|GO:0031683|GO:0042060|GO:0032549|GO:0007599|GO:0001664|GO:0017076|GO:0032561|GO:0007200|GO:0005525|GO:0019001|GO:0016462|GO:0007212|GO:0017111|GO:0060158|GO:0003924 macromolecular complex|signal transducer activity|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|extrinsic component of membrane|organic cyclic compound binding|macromolecular complex binding|regulation of cellular process|response to stress|ion binding|membrane-bounded organelle|cell periphery|hydrolase activity|intracellular|protein binding|plasma membrane|protein complex|coagulation|cytoplasmic side of plasma membrane|plasma membrane protein complex|receptor binding|anion binding|nucleoside binding|vesicle|hydrolase activity, acting on acid anhydrides|cation binding|response to wounding|protein complex binding|extrinsic component of cytoplasmic side of plasma membrane|cell activation|cytoplasmic side of membrane|extrinsic component of plasma membrane|cell communication|signal transduction|extracellular exosome|heterotrimeric G-protein complex|nucleotide binding|regulation of body fluid levels|G-protein coupled receptor signaling pathway|platelet activation|metal ion binding|purine ribonucleoside triphosphate binding|blood coagulation|purine nucleoside binding|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|G-protein beta/gamma-subunit complex binding|wound healing|ribonucleoside binding|hemostasis|G-protein coupled receptor binding|purine nucleotide binding|guanyl ribonucleotide binding|phospholipase C-activating G-protein coupled receptor signaling pathway|GTP binding|guanyl nucleotide binding|pyrophosphatase activity|dopamine receptor signaling pathway|nucleoside-triphosphatase activity|phospholipase C-activating dopamine receptor signaling pathway|GTPase activity K04636 guanine nucleotide-binding protein subunit alpha-14[-] hsa04020|hsa05142|hsa05146 Calcium signaling pathway - Homo sapiens (human)|Chagas disease (American trypanosomiasis) - Homo sapiens (human)|Amoebiasis - Homo sapiens (human) 9:77423079-77648307 1 0 3 5 6 8 0.0244698110036701 0 0.0661482648040358 0.109568535244865 0.120402835912626 0.183387441138363 0.0302060252692353 0.137786270765285 -2.1895238816106 0.0105743547379017 0.0436393124613379 DOWN ENSG00000130783 CCDC62 coiled-coil domain containing 62 [Source:HGNC Symbol;Acc:HGNC:30723] GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0051716|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0043227|GO:0071944|GO:0009893|GO:0009058|GO:0005622|GO:0005515|GO:0005886|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0005102|GO:0034641|GO:0031325|GO:0046483|GO:0043231|GO:0005737|GO:0006139|GO:0009725|GO:0044249|GO:0010033|GO:0031323|GO:0003713|GO:0010468|GO:0034645|GO:0033993|GO:0051427|GO:0051252|GO:0010628|GO:0031981|GO:0005654|GO:0014070|GO:0010467|GO:0071310|GO:0031328|GO:0009059|GO:0016070|GO:0032870|GO:0010557|GO:0005634|GO:0048545|GO:0097305|GO:0045893|GO:0032774|GO:2001141|GO:0035257|GO:0043627|GO:0071383|GO:0071407|GO:0030374|GO:0032355|GO:0071396|GO:0006351|GO:0006355|GO:0045944|GO:0006366|GO:0035258|GO:0006357|GO:1903506|GO:0071392|GO:0071391|GO:0030331 cell|membrane|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|cell periphery|positive regulation of metabolic process|biosynthetic process|intracellular|protein binding|plasma membrane|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|receptor binding|cellular nitrogen compound metabolic process|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cytoplasm|nucleobase-containing compound metabolic process|response to hormone|cellular biosynthetic process|response to organic substance|regulation of cellular metabolic process|transcription coactivator activity|regulation of gene expression|cellular macromolecule biosynthetic process|response to lipid|hormone receptor binding|regulation of RNA metabolic process|positive regulation of gene expression|nuclear lumen|nucleoplasm|response to organic cyclic compound|gene expression|cellular response to organic substance|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|RNA metabolic process|cellular response to hormone stimulus|positive regulation of macromolecule biosynthetic process|nucleus|response to steroid hormone|response to alcohol|positive regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nuclear hormone receptor binding|response to estrogen|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|ligand-dependent nuclear receptor transcription coactivator activity|response to estradiol|cellular response to lipid|transcription, DNA-templated|regulation of transcription, DNA-templated|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|steroid hormone receptor binding|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|cellular response to estradiol stimulus|cellular response to estrogen stimulus|estrogen receptor binding - - - - 12:122774327-122827528 15 16 10 7 2 8 0.139261920815976 0.135004178142159 0.0837092164282892 0.0582273144955795 0.0152340640267452 0.0696097230308632 0.119325105128808 0.047690367184396 1.32312781175735 0.0105937582401338 0.0437012655107024 UP ENSG00000239775 AC017116.11 - - - - - - - 7:44064908-44066079 12 13 17 6 7 6 0.645527769069869 0.635563005084238 0.824481756477004 0.289190202008371 0.308949223607352 0.302498090507004 0.70185751021037 0.300212505374242 1.22519409324802 0.0106720496194286 0.0439816909633379 UP ENSG00000267980 AC007292.6 - - - - - - - 19:4363789-4364640 18 14 24 9 4 12 1.7067967748202 1.20646411408441 2.05175133990266 0.764605381173579 0.311175157693758 1.06635316525874 1.65500407626909 0.714044568042026 1.21274874048118 0.0107663363013621 0.0443094971272451 UP ENSG00000230701 FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:13609] - - - - - - 22:23262767-23265005 14 19 10 6 6 7 0.442311809836181 0.545551212219826 0.284850611865625 0.169845965002683 0.155518089084107 0.207266964892554 0.424237877973877 0.177543672993115 1.25669948838628 0.0107834236272774 0.0443733051645401 UP ENSG00000258891 RP5-1021I20.5 - - - - - - - 14:73896164-73938114 9 8 14 5 5 2 0.158485236994756 0.128030474640915 0.222278498370423 0.0788827990859225 0.0722429413054259 0.0330026115896032 0.169598070002031 0.0613761173269839 1.46637046391457 0.0107898857963419 0.0443892338345118 UP ENSG00000280852 CTD-2319I12.10 - - - - - - - 17:60101759-60102919 16 11 19 26 50 31 0.707819429718285 0.442270636352492 0.757817144315627 1.03054287027246 1.81481095030712 1.28526589975664 0.635969070128801 1.37687324011207 -1.11436723795324 0.0107929778070172 0.0443942628066537 DOWN ENSG00000081665 ZNF506 zinc finger protein 506 [Source:HGNC Symbol;Acc:HGNC:23780] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0005730|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0031981|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0001159|GO:0000977|GO:0000987|GO:0000978 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|nucleolus|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|nuclear lumen|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|core promoter proximal region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding|core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding - - - - 19:19785839-19821751 2 9 5 14 16 16 0.00986245997604086 0.0403385487569364 0.0222292865174776 0.061860843313977 0.0647382035629606 0.0739481985181465 0.0241434317501516 0.0668490817983614 -1.4692769888952 0.0108307792338558 0.0445190807169947 DOWN ENSG00000130427 EPO erythropoietin [Source:HGNC Symbol;Acc:HGNC:3415] GO:0032502|GO:0000003|GO:0002376|GO:0023052|GO:0005623|GO:0009987|GO:0005576|GO:0022414|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0009892|GO:0048523|GO:0008283|GO:0050794|GO:0045321|GO:0006807|GO:0006950|GO:0044702|GO:0071704|GO:0009628|GO:0009986|GO:0051051|GO:0044237|GO:0051641|GO:0023051|GO:0016043|GO:0051707|GO:0007155|GO:0002262|GO:0009607|GO:0009605|GO:0023057|GO:0009893|GO:0009058|GO:0005615|GO:0030234|GO:0002684|GO:0050793|GO:0002682|GO:0002520|GO:0005515|GO:0048856|GO:0019222|GO:0060341|GO:0008284|GO:0042127|GO:0016337|GO:0045595|GO:0006725|GO:0051602|GO:0070661|GO:0048468|GO:0050867|GO:0006810|GO:0051130|GO:1901360|GO:0010941|GO:0009991|GO:0007275|GO:0048513|GO:0070489|GO:0034101|GO:0005102|GO:0034641|GO:0008047|GO:0006952|GO:0030155|GO:0031325|GO:0046483|GO:0051128|GO:0033554|GO:0007566|GO:0098609|GO:0045597|GO:0009611|GO:0042592|GO:0002696|GO:0001775|GO:0009966|GO:0009890|GO:0019725|GO:0060548|GO:0032387|GO:0010646|GO:0006139|GO:0043085|GO:0009617|GO:0046649|GO:0050865|GO:0007154|GO:0044092|GO:0055085|GO:0007565|GO:0007165|GO:0010523|GO:0009968|GO:0051649|GO:0045785|GO:2000021|GO:0009725|GO:0008219|GO:0001666|GO:0006970|GO:0050790|GO:0030030|GO:0032410|GO:0019207|GO:0048869|GO:0009967|GO:0044249|GO:0019538|GO:0023014|GO:0010033|GO:0031324|GO:0031323|GO:0003013|GO:0034763|GO:0043271|GO:0055093|GO:0007568|GO:0007584|GO:0000165|GO:1902533|GO:0051249|GO:0032268|GO:0031175|GO:0031344|GO:0010468|GO:0005126|GO:0034645|GO:1901215|GO:0032943|GO:0030218|GO:0033993|GO:0043412|GO:0030097|GO:0034097|GO:0010629|GO:0002237|GO:0010720|GO:0043620|GO:0019887|GO:0043069|GO:0048678|GO:2001234|GO:0048878|GO:0051252|GO:0005179|GO:0032386|GO:0034109|GO:0070997|GO:0009651|GO:0031346|GO:0010628|GO:0020027|GO:0051926|GO:0051347|GO:0036211|GO:0071456|GO:0046907|GO:0048872|GO:0006811|GO:0006954|GO:0055082|GO:0033273|GO:0051251|GO:0032413|GO:0022407|GO:0047484|GO:0050769|GO:0071470|GO:0007159|GO:0034766|GO:0051247|GO:0034765|GO:0006259|GO:0006972|GO:1901214|GO:0071453|GO:0043269|GO:0032270|GO:0042110|GO:0012501|GO:0014070|GO:0051054|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0010467|GO:0019209|GO:0007399|GO:1902532|GO:0031328|GO:0051246|GO:0046651|GO:0009059|GO:0010522|GO:0030154|GO:0022409|GO:0048469|GO:1902531|GO:0016070|GO:0031667|GO:0008015|GO:0010557|GO:0032496|GO:0043067|GO:0048545|GO:0097305|GO:0022898|GO:0051960|GO:0097190|GO:0034220|GO:0048666|GO:0030182|GO:0042098|GO:0045893|GO:0097193|GO:0098655|GO:0010975|GO:2001242|GO:0031401|GO:0050863|GO:0006260|GO:0070555|GO:0042541|GO:0043408|GO:0045892|GO:0008627|GO:2001258|GO:0032774|GO:0006812|GO:2001141|GO:2001243|GO:1902219|GO:0016310|GO:0061418|GO:0002526|GO:0043627|GO:0034112|GO:1902679|GO:0060402|GO:0070371|GO:0070486|GO:0016482|GO:0032412|GO:0005128|GO:0030295|GO:0043410|GO:0006275|GO:0042981|GO:0050801|GO:0043066|GO:0048821|GO:0051057|GO:0033574|GO:0043249|GO:0030099|GO:0045740|GO:0051056|GO:0022008|GO:0007264|GO:0071474|GO:0006464|GO:0050870|GO:0050767|GO:0033189|GO:0050671|GO:0010976|GO:0043549|GO:0006351|GO:0006915|GO:0006355|GO:0006873|GO:0043618|GO:1903039|GO:0033674|GO:0032946|GO:0036294|GO:0045666|GO:0006366|GO:0007259|GO:0007265|GO:0046578|GO:0045859|GO:1903507|GO:0045860|GO:0006357|GO:0006468|GO:0048699|GO:1903506|GO:0046579|GO:0046425|GO:0042325|GO:0033028|GO:0070374|GO:0033032|GO:0001932|GO:0018193|GO:0046427|GO:0030001|GO:0001934|GO:0050798|GO:0051924|GO:0006953|GO:0042129|GO:0000122|GO:2001257|GO:0070372|GO:0071593|GO:0045664|GO:0030003|GO:0042327|GO:0042102|GO:0033033|GO:0050731|GO:0050730|GO:0046006|GO:0042104|GO:0055065|GO:0007260|GO:0006875|GO:0018105|GO:0042531|GO:0032147|GO:1902251|GO:0018108|GO:0042506|GO:0042523|GO:0006874|GO:0006816|GO:0055074|GO:0051480|GO:0060401|GO:0007204 developmental process|reproduction|immune system process|signaling|cell|cellular process|extracellular region|reproductive process|metabolic process|response to stimulus|binding|cellular response to stimulus|negative regulation of metabolic process|negative regulation of cellular process|cell proliferation|regulation of cellular process|leukocyte activation|nitrogen compound metabolic process|response to stress|single organism reproductive process|organic substance metabolic process|response to abiotic stimulus|cell surface|negative regulation of transport|cellular metabolic process|cellular localization|regulation of signaling|cellular component organization|response to other organism|cell adhesion|myeloid cell homeostasis|response to biotic stimulus|response to external stimulus|negative regulation of signaling|positive regulation of metabolic process|biosynthetic process|extracellular space|enzyme regulator activity|positive regulation of immune system process|regulation of developmental process|regulation of immune system process|immune system development|protein binding|anatomical structure development|regulation of metabolic process|regulation of cellular localization|positive regulation of cell proliferation|regulation of cell proliferation|single organismal cell-cell adhesion|regulation of cell differentiation|cellular aromatic compound metabolic process|response to electrical stimulus|leukocyte proliferation|cell development|positive regulation of cell activation|transport|positive regulation of cellular component organization|organic cyclic compound metabolic process|regulation of cell death|response to extracellular stimulus|multicellular organism development|animal organ development|T cell aggregation|erythrocyte homeostasis|receptor binding|cellular nitrogen compound metabolic process|enzyme activator activity|defense response|regulation of cell adhesion|positive regulation of cellular metabolic process|heterocycle metabolic process|regulation of cellular component organization|cellular response to stress|embryo implantation|cell-cell adhesion|positive regulation of cell differentiation|response to wounding|homeostatic process|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|negative regulation of biosynthetic process|cellular homeostasis|negative regulation of cell death|negative regulation of intracellular transport|regulation of cell communication|nucleobase-containing compound metabolic process|positive regulation of catalytic activity|response to bacterium|lymphocyte activation|regulation of cell activation|cell communication|negative regulation of molecular function|transmembrane transport|female pregnancy|signal transduction|negative regulation of calcium ion transport into cytosol|negative regulation of signal transduction|establishment of localization in cell|positive regulation of cell adhesion|regulation of ion homeostasis|response to hormone|cell death|response to hypoxia|response to osmotic stress|regulation of catalytic activity|cell projection organization|negative regulation of transporter activity|kinase regulator activity|cellular developmental process|positive regulation of signal transduction|cellular biosynthetic process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|negative regulation of cellular metabolic process|regulation of cellular metabolic process|circulatory system process|negative regulation of transmembrane transport|negative regulation of ion transport|response to hyperoxia|aging|response to nutrient|MAPK cascade|positive regulation of intracellular signal transduction|regulation of lymphocyte activation|regulation of cellular protein metabolic process|neuron projection development|regulation of cell projection organization|regulation of gene expression|cytokine receptor binding|cellular macromolecule biosynthetic process|negative regulation of neuron death|mononuclear cell proliferation|erythrocyte differentiation|response to lipid|macromolecule modification|hemopoiesis|response to cytokine|negative regulation of gene expression|response to molecule of bacterial origin|positive regulation of cell development|regulation of DNA-templated transcription in response to stress|protein kinase regulator activity|negative regulation of programmed cell death|response to axon injury|negative regulation of apoptotic signaling pathway|chemical homeostasis|regulation of RNA metabolic process|hormone activity|regulation of intracellular transport|homotypic cell-cell adhesion|neuron death|response to salt stress|positive regulation of cell projection organization|positive regulation of gene expression|hemoglobin metabolic process|negative regulation of calcium ion transport|positive regulation of transferase activity|protein modification process|cellular response to hypoxia|intracellular transport|homeostasis of number of cells|ion transport|inflammatory response|cellular chemical homeostasis|response to vitamin|positive regulation of lymphocyte activation|negative regulation of ion transmembrane transporter activity|regulation of cell-cell adhesion|regulation of response to osmotic stress|positive regulation of neurogenesis|cellular response to osmotic stress|leukocyte cell-cell adhesion|negative regulation of ion transmembrane transport|positive regulation of protein metabolic process|regulation of ion transmembrane transport|DNA metabolic process|hyperosmotic response|regulation of neuron death|cellular response to oxygen levels|regulation of ion transport|positive regulation of cellular protein metabolic process|T cell activation|programmed cell death|response to organic cyclic compound|positive regulation of DNA metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|gene expression|kinase activator activity|nervous system development|negative regulation of intracellular signal transduction|positive regulation of cellular biosynthetic process|regulation of protein metabolic process|lymphocyte proliferation|macromolecule biosynthetic process|regulation of calcium ion transport into cytosol|cell differentiation|positive regulation of cell-cell adhesion|cell maturation|regulation of intracellular signal transduction|RNA metabolic process|response to nutrient levels|blood circulation|positive regulation of macromolecule biosynthetic process|response to lipopolysaccharide|regulation of programmed cell death|response to steroid hormone|response to alcohol|regulation of transmembrane transporter activity|regulation of nervous system development|apoptotic signaling pathway|ion transmembrane transport|neuron development|neuron differentiation|T cell proliferation|positive regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway|cation transmembrane transport|regulation of neuron projection development|regulation of intrinsic apoptotic signaling pathway|positive regulation of protein modification process|regulation of T cell activation|DNA replication|response to interleukin-1|hemoglobin biosynthetic process|regulation of MAPK cascade|negative regulation of transcription, DNA-templated|intrinsic apoptotic signaling pathway in response to osmotic stress|negative regulation of cation channel activity|RNA biosynthetic process|cation transport|regulation of RNA biosynthetic process|negative regulation of intrinsic apoptotic signaling pathway|negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress|phosphorylation|regulation of transcription from RNA polymerase II promoter in response to hypoxia|acute inflammatory response|response to estrogen|positive regulation of homotypic cell-cell adhesion|negative regulation of RNA biosynthetic process|calcium ion transport into cytosol|ERK1 and ERK2 cascade|leukocyte aggregation|cytosolic transport|regulation of ion transmembrane transporter activity|erythropoietin receptor binding|protein kinase activator activity|positive regulation of MAPK cascade|regulation of DNA replication|regulation of apoptotic process|ion homeostasis|negative regulation of apoptotic process|erythrocyte development|positive regulation of small GTPase mediated signal transduction|response to testosterone|erythrocyte maturation|myeloid cell differentiation|positive regulation of DNA replication|regulation of small GTPase mediated signal transduction|neurogenesis|small GTPase mediated signal transduction|cellular hyperosmotic response|cellular protein modification process|positive regulation of T cell activation|regulation of neurogenesis|response to vitamin A|positive regulation of lymphocyte proliferation|positive regulation of neuron projection development|regulation of kinase activity|transcription, DNA-templated|apoptotic process|regulation of transcription, DNA-templated|cellular ion homeostasis|regulation of transcription from RNA polymerase II promoter in response to stress|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|positive regulation of mononuclear cell proliferation|cellular response to decreased oxygen levels|positive regulation of neuron differentiation|transcription from RNA polymerase II promoter|JAK-STAT cascade|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|negative regulation of nucleic acid-templated transcription|positive regulation of protein kinase activity|regulation of transcription from RNA polymerase II promoter|protein phosphorylation|generation of neurons|regulation of nucleic acid-templated transcription|positive regulation of Ras protein signal transduction|regulation of JAK-STAT cascade|regulation of phosphorylation|myeloid cell apoptotic process|positive regulation of ERK1 and ERK2 cascade|regulation of myeloid cell apoptotic process|regulation of protein phosphorylation|peptidyl-amino acid modification|positive regulation of JAK-STAT cascade|metal ion transport|positive regulation of protein phosphorylation|activated T cell proliferation|regulation of calcium ion transport|acute-phase response|regulation of T cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of cation channel activity|regulation of ERK1 and ERK2 cascade|lymphocyte aggregation|regulation of neuron differentiation|cellular cation homeostasis|positive regulation of phosphorylation|positive regulation of T cell proliferation|negative regulation of myeloid cell apoptotic process|positive regulation of peptidyl-tyrosine phosphorylation|regulation of peptidyl-tyrosine phosphorylation|regulation of activated T cell proliferation|positive regulation of activated T cell proliferation|metal ion homeostasis|tyrosine phosphorylation of STAT protein|cellular metal ion homeostasis|peptidyl-serine phosphorylation|positive regulation of tyrosine phosphorylation of STAT protein|activation of protein kinase activity|negative regulation of erythrocyte apoptotic process|peptidyl-tyrosine phosphorylation|tyrosine phosphorylation of Stat5 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|cellular calcium ion homeostasis|calcium ion transport|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|cytosolic calcium ion transport|positive regulation of cytosolic calcium ion concentration K05437 erythropoietin[-] hsa04151|hsa04060|hsa04630|hsa04066|hsa04640 PI3K-Akt signaling pathway - Homo sapiens (human)|Cytokine-cytokine receptor interaction - Homo sapiens (human)|Jak-STAT signaling pathway - Homo sapiens (human)|HIF-1 signaling pathway - Homo sapiens (human)|Hematopoietic cell lineage - Homo sapiens (human) 7:100720800-100723700 4 5 3 1 1 0 0.212732520144857 0.241704462446028 0.143835174295693 0.0476306718051218 0.0436565620934981 0 0.199424052295526 0.0304290779662066 2.71231689753099 0.0108542822568657 0.0445988513320957 UP ENSG00000235527 HIPK1-AS1 HIPK1 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:50576] - - - - - - 1:113924000-113929492 4 5 6 12 19 12 0.0619112148342801 0.070342874191076 0.0837348603895582 0.166426746451207 0.241298983219088 0.174069904000661 0.0719963164716381 0.193931877890319 -1.42955496711476 0.0108748824237318 0.0446573232294484 DOWN ENSG00000063438 AHRR aryl-hydrocarbon receptor repressor [Source:HGNC Symbol;Acc:HGNC:346] GO:0005623|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0000988|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0000989|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0009410|GO:0034641|GO:0046483|GO:0005737|GO:0001076|GO:0046983|GO:0009890|GO:0006139|GO:0044249|GO:0031324|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0051252|GO:0010467|GO:0009059|GO:0001191|GO:0016070|GO:0045892|GO:0032774|GO:2001141|GO:1902679|GO:0006351|GO:0006355|GO:0006366|GO:1903507|GO:0006357|GO:1903506|GO:0000122 cell|cellular process|metabolic process|response to stimulus|binding|transcription factor activity, protein binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|transcription factor activity, transcription factor binding|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|response to xenobiotic stimulus|cellular nitrogen compound metabolic process|heterocycle metabolic process|cytoplasm|transcription factor activity, RNA polymerase II transcription factor binding|protein dimerization activity|negative regulation of biosynthetic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|transcriptional repressor activity, RNA polymerase II transcription factor binding|RNA metabolic process|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|negative regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|negative regulation of nucleic acid-templated transcription|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|negative regulation of transcription from RNA polymerase II promoter - - - - 5:304176-438291 31 24 55 56 65 127 0.162228293468703 0.114144799134251 0.259502310963131 0.262573019868214 0.279091691589316 0.622871007932694 0.178625134522028 0.388178573130075 -1.11978538785527 0.0109664720922397 0.0449962971195332 DOWN ENSG00000143502 SUSD4 sushi domain containing 4 [Source:HGNC Symbol;Acc:HGNC:25470] GO:0002376|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0002683|GO:0009892|GO:0048523|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0009605|GO:0031224|GO:0002684|GO:0002682|GO:0019222|GO:0002250|GO:0045087|GO:0006959|GO:0006952|GO:0009611|GO:0006956|GO:0050776|GO:0050778|GO:0050777|GO:0016021|GO:0019538|GO:0031324|GO:0031323|GO:0002443|GO:0032268|GO:0010468|GO:0006958|GO:0010629|GO:0050727|GO:0045824|GO:0051604|GO:0032269|GO:0006954|GO:0006957|GO:0030449|GO:0006508|GO:0002820|GO:0002460|GO:0044267|GO:0010467|GO:0002819|GO:0051246|GO:0002455|GO:0002920|GO:0045916|GO:0045088|GO:0002673|GO:0016485|GO:0030162|GO:0002526|GO:0002924|GO:0045959|GO:0045861|GO:0019724|GO:0045957|GO:0016064|GO:0010955|GO:0070613 immune system process|membrane|cellular process|extracellular region|metabolic process|response to stimulus|negative regulation of immune system process|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|response to external stimulus|intrinsic component of membrane|positive regulation of immune system process|regulation of immune system process|regulation of metabolic process|adaptive immune response|innate immune response|humoral immune response|defense response|response to wounding|complement activation|regulation of immune response|positive regulation of immune response|negative regulation of immune response|integral component of membrane|protein metabolic process|negative regulation of cellular metabolic process|regulation of cellular metabolic process|leukocyte mediated immunity|regulation of cellular protein metabolic process|regulation of gene expression|complement activation, classical pathway|negative regulation of gene expression|regulation of inflammatory response|negative regulation of innate immune response|protein maturation|negative regulation of cellular protein metabolic process|inflammatory response|complement activation, alternative pathway|regulation of complement activation|proteolysis|negative regulation of adaptive immune response|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|cellular protein metabolic process|gene expression|regulation of adaptive immune response|regulation of protein metabolic process|humoral immune response mediated by circulating immunoglobulin|regulation of humoral immune response|negative regulation of complement activation|regulation of innate immune response|regulation of acute inflammatory response|protein processing|regulation of proteolysis|acute inflammatory response|negative regulation of humoral immune response mediated by circulating immunoglobulin|negative regulation of complement activation, classical pathway|negative regulation of proteolysis|B cell mediated immunity|negative regulation of complement activation, alternative pathway|immunoglobulin mediated immune response|negative regulation of protein processing|regulation of protein processing - - - - 1:223220819-223364202 16 16 16 24 44 40 0.10307862186881 0.0936791287126695 0.0929370520899286 0.138531543201456 0.232575383249706 0.241510236690413 0.0965649342238027 0.204205721047192 -1.08045198431022 0.0110105440080757 0.0451647129454646 DOWN ENSG00000249673 NOP14-AS1 NOP14 antisense RNA 1 [Source:HGNC Symbol;Acc:HGNC:20205] - - - - - - 4:2934899-2961738 38 33 131 26 41 27 0.226625740993851 0.178864462799693 0.704383373436589 0.1389290995334 0.200619353062782 0.150908580680347 0.369957859076711 0.163485677758843 1.17819669324726 0.0110161397529148 0.0451752522230109 UP ENSG00000220685 RP11-530A18.1 - - - - - - - 6:5065795-5066982 1 0 0 2 3 6 0.059567923756409 0 0 0.106701772065378 0.14657538838731 0.334835849340665 0.0198559745854697 0.196037669931118 -3.30348582521928 0.0110337959168696 0.0452290187151207 DOWN ENSG00000105668 UPK1A uroplakin 1A [Source:HGNC Symbol;Acc:HGNC:12577] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0050896|GO:0005488|GO:0036094|GO:1903561|GO:0051716|GO:0050794|GO:0043229|GO:0045177|GO:0016043|GO:0030246|GO:0043227|GO:0071944|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0012505|GO:0048856|GO:0042802|GO:0048029|GO:0009888|GO:0016324|GO:0031982|GO:0022607|GO:0005887|GO:0043231|GO:0005737|GO:0046983|GO:0031226|GO:0007154|GO:0007165|GO:0005783|GO:0070062|GO:0048869|GO:0016021|GO:0007166|GO:0006461|GO:0060429|GO:0030154|GO:0042803|GO:0051259|GO:0030855 developmental process|signaling|cell|membrane|cellular process|extracellular region|response to stimulus|binding|small molecule binding|extracellular vesicle|cellular response to stimulus|regulation of cellular process|intracellular organelle|apical part of cell|cellular component organization|carbohydrate binding|membrane-bounded organelle|cell periphery|intrinsic component of membrane|intracellular|protein binding|plasma membrane|endomembrane system|anatomical structure development|identical protein binding|monosaccharide binding|tissue development|apical plasma membrane|vesicle|cellular component assembly|integral component of plasma membrane|intracellular membrane-bounded organelle|cytoplasm|protein dimerization activity|intrinsic component of plasma membrane|cell communication|signal transduction|endoplasmic reticulum|extracellular exosome|cellular developmental process|integral component of membrane|cell surface receptor signaling pathway|protein complex assembly|epithelium development|cell differentiation|protein homodimerization activity|protein oligomerization|epithelial cell differentiation - - - - 19:35666516-35678483 6 8 22 4 4 5 0.199530501969436 0.241795212333125 0.659638173753624 0.119192952716191 0.109138066591229 0.155852958927594 0.366987962685395 0.128061326078338 1.51889788871927 0.0110777316881325 0.0453904202329823 UP ENSG00000261253 AC137932.6 - - - - - - - 16:89321133-89325110 17 15 15 9 6 7 0.55723063048807 0.446867449417939 0.44329814910743 0.264316781443693 0.161355422362982 0.21504667951549 0.482465409671146 0.213572961107388 1.17569650251302 0.0111080540482921 0.0455021741983687 UP ENSG00000187672 ERC2 ELKS/RAB6-interacting/CAST family member 2 [Source:HGNC Symbol;Acc:HGNC:31922] GO:0045202|GO:0005623|GO:0016020|GO:0030054|GO:0005488|GO:0042995|GO:0048786|GO:0043229|GO:0030427|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0097060|GO:0030426|GO:0005737|GO:0042734|GO:0043005|GO:0005856 synapse|cell|membrane|cell junction|binding|cell projection|presynaptic active zone|intracellular organelle|site of polarized growth|cell periphery|intracellular|protein binding|plasma membrane|synaptic membrane|growth cone|cytoplasm|presynaptic membrane|neuron projection|cytoskeleton - - - - 3:55508308-56468363 0 0 1 3 2 6 0 0 0.00373081340394735 0.0111266825889314 0.00679318353153293 0.0232813408063157 0.00124360446798245 0.01373373564226 -3.46512448868411 0.0111154195042815 0.0455224733346178 DOWN ENSG00000159173 TNNI1 troponin I type 1 (skeletal, slow) [Source:HGNC Symbol;Acc:HGNC:11945] GO:0032502|GO:0032991|GO:0005623|GO:0009987|GO:0050896|GO:0005488|GO:0043229|GO:0043167|GO:0009653|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0030017|GO:0007507|GO:0009888|GO:0007275|GO:0048513|GO:0061061|GO:0043169|GO:0005737|GO:0003012|GO:0006928|GO:0009887|GO:0048729|GO:0008092|GO:0030029|GO:0005861|GO:0003013|GO:0003205|GO:0014733|GO:0005829|GO:0006936|GO:0046872|GO:0005865|GO:0003208|GO:0072358|GO:0030048|GO:0048738|GO:0003779|GO:0003007|GO:0090257|GO:0060537|GO:0043292|GO:0003231|GO:0060415|GO:0007517|GO:0072359|GO:0008015|GO:0005856|GO:0050881|GO:0048644|GO:0006941|GO:0015629|GO:0070252|GO:0030016|GO:0006937|GO:0003009|GO:0060047|GO:0030049|GO:0003229|GO:0055008|GO:0014706|GO:0055010|GO:0014883|GO:0033275|GO:0006942|GO:0060048 developmental process|macromolecular complex|cell|cellular process|response to stimulus|binding|intracellular organelle|ion binding|anatomical structure morphogenesis|intracellular|protein binding|protein complex|anatomical structure development|sarcomere|heart development|tissue development|multicellular organism development|animal organ development|muscle structure development|cation binding|cytoplasm|muscle system process|movement of cell or subcellular component|organ morphogenesis|tissue morphogenesis|cytoskeletal protein binding|actin filament-based process|troponin complex|circulatory system process|cardiac chamber development|regulation of skeletal muscle adaptation|cytosol|muscle contraction|metal ion binding|striated muscle thin filament|cardiac ventricle morphogenesis|cardiovascular system development|actin filament-based movement|cardiac muscle tissue development|actin binding|heart morphogenesis|regulation of muscle system process|muscle tissue development|contractile fiber|cardiac ventricle development|muscle tissue morphogenesis|muscle organ development|circulatory system development|blood circulation|cytoskeleton|musculoskeletal movement|muscle organ morphogenesis|striated muscle contraction|actin cytoskeleton|actin-mediated cell contraction|myofibril|regulation of muscle contraction|skeletal muscle contraction|heart contraction|muscle filament sliding|ventricular cardiac muscle tissue development|cardiac muscle tissue morphogenesis|striated muscle tissue development|ventricular cardiac muscle tissue morphogenesis|transition between fast and slow fiber|actin-myosin filament sliding|regulation of striated muscle contraction|cardiac muscle contraction - - - - 1:201403768-201429866 17 16 13 36 28 39 0.089759177472065 0.0767781468437047 0.0618855939225503 0.170310261673061 0.121301255219427 0.192990718331195 0.0761409727461067 0.161534078407894 -1.08509365208629 0.0111383324940242 0.0455991208487167 DOWN ENSG00000224785 AC006026.9 - - - - - - - 7:23562459-23564261 6 9 6 2 4 1 0.235386232772596 0.320918548735161 0.212239773699546 0.0703059929083025 0.128750231635909 0.0367641405311803 0.256181518402434 0.0786067883584639 1.70444058783222 0.011166464806195 0.0456975517922065 UP ENSG00000267353 CTD-2162K18.3 - - - - - - - 19:36773712-36775908 1 5 5 0 1 0 0.032210602377157 0.14632086256405 0.145132856534683 0 0.026428414922327 0 0.10788810715863 0.00880947164077567 3.61433653632984 0.0111986798857052 0.0458168273684861 UP ENSG00000102387 TAF7L TATA-box binding protein associated factor 7 like [Source:HGNC Symbol;Acc:HGNC:11548] GO:0032502|GO:0032991|GO:0000003|GO:0005623|GO:0009987|GO:0022414|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0044702|GO:0071704|GO:0019953|GO:0044237|GO:0000989|GO:0016043|GO:0043227|GO:0032504|GO:0009058|GO:0005622|GO:0005515|GO:0043234|GO:0048856|GO:0048609|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0007275|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0019899|GO:0005737|GO:0005667|GO:0006139|GO:0007276|GO:0008134|GO:0048869|GO:0044249|GO:0031323|GO:0003713|GO:0003677|GO:0010468|GO:0034645|GO:0048232|GO:0044798|GO:0035035|GO:0051252|GO:0031981|GO:1990234|GO:0005654|GO:0010467|GO:0009059|GO:0030154|GO:0016070|GO:0005634|GO:0007283|GO:0000975|GO:0034622|GO:0032774|GO:2001141|GO:0065004|GO:0005669|GO:0090575|GO:0016591|GO:0006351|GO:0006355|GO:0006366|GO:0006352|GO:0006357|GO:1903506|GO:0044212|GO:0006367|GO:0051123 developmental process|macromolecular complex|reproduction|cell|cellular process|reproductive process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|single organism reproductive process|organic substance metabolic process|sexual reproduction|cellular metabolic process|transcription factor activity, transcription factor binding|cellular component organization|membrane-bounded organelle|multicellular organism reproduction|biosynthetic process|intracellular|protein binding|protein complex|anatomical structure development|multicellular organismal reproductive process|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|multicellular organism development|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|enzyme binding|cytoplasm|transcription factor complex|nucleobase-containing compound metabolic process|gamete generation|transcription factor binding|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|transcription coactivator activity|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|male gamete generation|nuclear transcription factor complex|histone acetyltransferase binding|regulation of RNA metabolic process|nuclear lumen|transferase complex|nucleoplasm|gene expression|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|nucleus|spermatogenesis|regulatory region DNA binding|cellular macromolecular complex assembly|RNA biosynthetic process|regulation of RNA biosynthetic process|protein-DNA complex assembly|transcription factor TFIID complex|RNA polymerase II transcription factor complex|DNA-directed RNA polymerase II, holoenzyme|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|DNA-templated transcription, initiation|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription initiation from RNA polymerase II promoter|RNA polymerase II transcriptional preinitiation complex assembly K03132 transcription initiation factor TFIID subunit 7[-] hsa03022 Basal transcription factors - Homo sapiens (human) X:101268253-101293057 1 1 0 5 6 3 0.0170892763638285 0.0155319311125186 0 0.0765206964327821 0.0840871773627904 0.0480215494163618 0.010873735825449 0.0695431410706448 -2.6770605472896 0.0112039088396088 0.0458256602956132 DOWN ENSG00000211829 TRDC T cell receptor delta constant [Source:HGNC Symbol;Acc:HGNC:12253] GO:0005623|GO:0016020|GO:0005488|GO:0009986|GO:0071944|GO:0005515|GO:0005886|GO:0009897 cell|membrane|binding|cell surface|cell periphery|protein binding|plasma membrane|external side of plasma membrane - - - - 14:22462932-22465787 3 0 0 7 6 6 0.294769193498533 0 0 0.616158207141417 0.483618057582382 0.552479151412098 0.0982563978328443 0.550751805378632 -2.48677906444103 0.0112098937977218 0.045843858827012 DOWN ENSG00000256625 RP11-582E3.4 - - - - - - - 12:27121910-27147664 1 0 0 3 2 6 0.0719905324746835 0 0 0.193398269292453 0.1180756193487 0.404664281807437 0.0239968441582278 0.238712723482863 -3.31435887110066 0.011218024081557 0.0458645427185434 DOWN ENSG00000279801 RP11-75C10.6 - - - - - - - 17:77444704-77447167 2 1 4 8 7 10 0.057413606289095 0.0261029735133682 0.103535798695963 0.20578198898323 0.164881586462527 0.269045442584246 0.0623507928328087 0.213236339343334 -1.77397351034034 0.0112166337729409 0.0458645427185434 DOWN ENSG00000146555 SDK1 sidekick cell adhesion molecule 1 [Source:HGNC Symbol;Acc:HGNC:19307] GO:0032502|GO:0045202|GO:0007610|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0030054|GO:0050896|GO:0005488|GO:1903561|GO:0050794|GO:0009653|GO:0016043|GO:0007155|GO:0043227|GO:0044708|GO:0071944|GO:0031224|GO:0050793|GO:0005515|GO:0005886|GO:0048856|GO:0048646|GO:0042802|GO:0045595|GO:0060041|GO:0009888|GO:0048468|GO:0030534|GO:0007275|GO:0048513|GO:0016358|GO:0031982|GO:0051128|GO:0022607|GO:0098609|GO:0010243|GO:0007423|GO:0009887|GO:0003407|GO:0048729|GO:0060996|GO:0070062|GO:0050808|GO:0010842|GO:0030030|GO:0048869|GO:0016021|GO:0010033|GO:0060998|GO:0031175|GO:0098742|GO:0031344|GO:0007416|GO:0001654|GO:0048148|GO:0050773|GO:0043279|GO:0060042|GO:0014070|GO:0060359|GO:0007399|GO:0030154|GO:0042220|GO:0051960|GO:0048666|GO:0030182|GO:0010975|GO:0043010|GO:0007156|GO:0022008|GO:0050767|GO:0048592|GO:0048593|GO:0048699|GO:0045664 developmental process|synapse|behavior|cell|membrane|cellular process|extracellular region|cell junction|response to stimulus|binding|extracellular vesicle|regulation of cellular process|anatomical structure morphogenesis|cellular component organization|cell adhesion|membrane-bounded organelle|single-organism behavior|cell periphery|intrinsic component of membrane|regulation of developmental process|protein binding|plasma membrane|anatomical structure development|anatomical structure formation involved in morphogenesis|identical protein binding|regulation of cell differentiation|retina development in camera-type eye|tissue development|cell development|adult behavior|multicellular organism development|animal organ development|dendrite development|vesicle|regulation of cellular component organization|cellular component assembly|cell-cell adhesion|response to organonitrogen compound|sensory organ development|organ morphogenesis|neural retina development|tissue morphogenesis|dendritic spine development|extracellular exosome|synapse organization|retina layer formation|cell projection organization|cellular developmental process|integral component of membrane|response to organic substance|regulation of dendritic spine development|neuron projection development|cell-cell adhesion via plasma-membrane adhesion molecules|regulation of cell projection organization|synapse assembly|eye development|behavioral response to cocaine|regulation of dendrite development|response to alkaloid|retina morphogenesis in camera-type eye|response to organic cyclic compound|response to ammonium ion|nervous system development|cell differentiation|response to cocaine|regulation of nervous system development|neuron development|neuron differentiation|regulation of neuron projection development|camera-type eye development|homophilic cell adhesion via plasma membrane adhesion molecules|neurogenesis|regulation of neurogenesis|eye morphogenesis|camera-type eye morphogenesis|generation of neurons|regulation of neuron differentiation - - - - 7:3301448-4269000 3 0 1 6 4 10 0.0136854410187609 0 0.00411043834278079 0.0245218671421852 0.0149688333530786 0.0427474832684797 0.00593195978718056 0.0274127279212478 -2.20826517924472 0.0112314346425695 0.0458942307444934 DOWN ENSG00000182040 USH1G Usher syndrome 1G (autosomal recessive) [Source:HGNC Symbol;Acc:HGNC:16356] GO:0032502|GO:0005623|GO:0016020|GO:0009987|GO:0005488|GO:0042995|GO:0043229|GO:0009653|GO:0016043|GO:0071944|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0005929|GO:0042802|GO:0048468|GO:0048839|GO:0007275|GO:0048513|GO:0050877|GO:0005737|GO:0007423|GO:0009887|GO:0042592|GO:0001917|GO:0046983|GO:0048598|GO:0048568|GO:0072372|GO:0045494|GO:0048871|GO:0036064|GO:0008092|GO:0030030|GO:0048869|GO:0005829|GO:0050905|GO:0060113|GO:0043583|GO:0001894|GO:0005815|GO:0009790|GO:0042472|GO:0007600|GO:0060122|GO:0048562|GO:0007399|GO:0030154|GO:0005856|GO:0042803|GO:0031513|GO:0030507|GO:0048666|GO:0030182|GO:0015629|GO:0050953|GO:0050954|GO:0032391|GO:0001895|GO:0042471|GO:0050885|GO:0015630|GO:0060119|GO:0022008|GO:0050957|GO:0007605|GO:0048699|GO:0042490 developmental process|cell|membrane|cellular process|binding|cell projection|intracellular organelle|anatomical structure morphogenesis|cellular component organization|cell periphery|intracellular|protein binding|plasma membrane|anatomical structure development|cilium|identical protein binding|cell development|inner ear development|multicellular organism development|animal organ development|neurological system process|cytoplasm|sensory organ development|organ morphogenesis|homeostatic process|photoreceptor inner segment|protein dimerization activity|embryonic morphogenesis|embryonic organ development|primary cilium|photoreceptor cell maintenance|multicellular organismal homeostasis|ciliary basal body|cytoskeletal protein binding|cell projection organization|cellular developmental process|cytosol|neuromuscular process|inner ear receptor cell differentiation|ear development|tissue homeostasis|microtubule organizing center|embryo development|inner ear morphogenesis|sensory perception|inner ear receptor stereocilium organization|embryonic organ morphogenesis|nervous system development|cell differentiation|cytoskeleton|protein homodimerization activity|nonmotile primary cilium|spectrin binding|neuron development|neuron differentiation|actin cytoskeleton|sensory perception of light stimulus|sensory perception of mechanical stimulus|photoreceptor connecting cilium|retina homeostasis|ear morphogenesis|neuromuscular process controlling balance|microtubule cytoskeleton|inner ear receptor cell development|neurogenesis|equilibrioception|sensory perception of sound|generation of neurons|mechanoreceptor differentiation - - - - 17:74916084-74923256 2 0 4 5 8 11 0.0289654229926966 0 0.0522342768195852 0.0648796486339375 0.0950719608165479 0.149306657638268 0.0270665666040939 0.103086089029584 -1.92926586280192 0.0112357247396112 0.0459054778125568 DOWN ENSG00000241293 PPATP1 phosphoribosyl pyrophosphate amidotransferase pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:9239] - - - - - - 3:87051192-87052738 5 3 3 16 14 7 0.228636680811425 0.124687996700115 0.123659199620731 0.65548126922903 0.525233650993752 0.29998108234934 0.158994625710757 0.493565334190707 -1.634263068851 0.0112437345790094 0.0459319173675078 DOWN ENSG00000141028 CDRT15P1 CMT1A duplicated region transcript 15 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:33168] - - - - - - 17:14024514-14025488 8 9 6 4 2 2 1.00331294961936 1.02591514781825 0.678489914858654 0.449509592956275 0.205794918120162 0.235055834672759 0.902572670765421 0.296786781916399 1.60461625583067 0.0113872231940097 0.0464545177963878 UP ENSG00000225675 RP4-784A16.5 - - - - - - - 1:53328233-53336509 4 5 9 17 16 15 0.499002207747196 0.566961084749942 1.01229117071173 1.90025120848354 1.63775095574446 1.75383988389167 0.692751487736289 1.76394734937322 -1.3483976905901 0.0113980062089231 0.0464900721253159 DOWN ENSG00000272968 RBAK-RBAKDN RBAK-RBAKDN readthrough [Source:HGNC Symbol;Acc:HGNC:42971] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0050794|GO:0006807|GO:0071704|GO:0044237|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0006139|GO:0044249|GO:0031323|GO:0010468|GO:0034645|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|binding|organic cyclic compound binding|regulation of cellular process|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|regulation of gene expression|cellular macromolecule biosynthetic process|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 7:4983718-5073221 17 13 20 3 8 11 1.14633336567517 0.796725788070327 1.21597811242542 0.181230218030964 0.442641998692107 0.695151302102289 1.05301242205697 0.43967450627512 1.26001466743864 0.0114119425839996 0.0465235742049332 UP ENSG00000134376 CRB1 crumbs family member 1, photoreceptor morphogenesis associated [Source:HGNC Symbol;Acc:HGNC:2343] GO:0032502|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0005488|GO:0042995|GO:0043167|GO:0045177|GO:0009653|GO:0016043|GO:0071944|GO:0031224|GO:0005515|GO:0005886|GO:0048856|GO:0048468|GO:0016324|GO:0007275|GO:0048513|GO:0043169|GO:0007267|GO:0007423|GO:0009887|GO:0007163|GO:0007154|GO:0061024|GO:0048869|GO:0016021|GO:0010256|GO:0046872|GO:0001654|GO:0007009|GO:0007399|GO:0005902|GO:0030154|GO:0048666|GO:0030182|GO:0042461|GO:0005509|GO:0022008|GO:0048592|GO:0048699|GO:0001754|GO:0042462 developmental process|signaling|cell|membrane|cellular process|extracellular region|binding|cell projection|ion binding|apical part of cell|anatomical structure morphogenesis|cellular component organization|cell periphery|intrinsic component of membrane|protein binding|plasma membrane|anatomical structure development|cell development|apical plasma membrane|multicellular organism development|animal organ development|cation binding|cell-cell signaling|sensory organ development|organ morphogenesis|establishment or maintenance of cell polarity|cell communication|membrane organization|cellular developmental process|integral component of membrane|endomembrane system organization|metal ion binding|eye development|plasma membrane organization|nervous system development|microvillus|cell differentiation|neuron development|neuron differentiation|photoreceptor cell development|calcium ion binding|neurogenesis|eye morphogenesis|generation of neurons|eye photoreceptor cell differentiation|eye photoreceptor cell development K16681 protein crumbs[-] hsa04390 Hippo signaling pathway - Homo sapiens (human) 1:197268204-197478455 0 0 1 2 2 10 0 0 0.00380066049486313 0.00755793615631227 0.00692036333292223 0.0395258747035287 0.00126688683162104 0.0180013913975877 -3.82874885999372 0.0114149171973147 0.0465293470792783 DOWN ENSG00000271858 CYB561D2 cytochrome b561 family member D2 [Source:EntrezGene;Acc:11068] - - - - - - 3:50365334-50368197 6 8 7 18 14 22 0.1590709811428 0.192765523475471 0.167321210569762 0.427582919306964 0.304548897334083 0.546663399010871 0.173052571729344 0.426265071883973 -1.30054046434934 0.0114197443135127 0.046536315415726 DOWN ENSG00000261072 RP11-5N19.3 - - - - - - - 15:56192353-56193262 1 0 1 3 5 6 0.0777655971677075 0 0.0700490965053236 0.20891263594998 0.318900983762523 0.437126361556825 0.049271564557677 0.321646660423109 -2.70664952113103 0.0114254726954786 0.0465533044698808 DOWN ENSG00000225285 RP4-758J18.10 - - - - - - - 1:1430539-1434573 4 2 3 10 8 13 0.140623385582833 0.0639038788062321 0.0950799114380077 0.315014177966375 0.23078104206164 0.428357715413091 0.0998690586090243 0.324717645147035 -1.70107610559092 0.0114303745746492 0.0465669217455756 DOWN ENSG00000253180 RP11-410L14.1 - - - - - - - 8:99003407-99003842 1 2 7 12 5 20 0.16230892986838 0.294895881096649 1.02388300412873 1.74442713596793 0.665596089963064 3.04095399324579 0.493695938364586 1.81699240639226 -1.87985770905575 0.0114867413851333 0.0467646498447796 DOWN ENSG00000188738 FSIP2 fibrous sheath interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:21675] GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005739 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|mitochondrion - - - - 2:185738628-185833290 8 7 14 21 20 28 0.01859391133261 0.0147879452965976 0.0293396223820849 0.0437342965083135 0.0381408819224739 0.0609934091554336 0.0209071596704308 0.0476228625287403 -1.18765726236872 0.0115087646651398 0.0468160049479608 DOWN ENSG00000270977 AC015849.16 - - - - - - - 17:35893707-35911023 4 17 4 13 38 30 0.0483317819939631 0.186695346771789 0.0435791267486939 0.140744623297374 0.376746277181835 0.339742813176145 0.0928687518381487 0.285744571218451 -1.62146093909002 0.0115366618385263 0.0469230929873794 DOWN ENSG00000157734 SNX22 sorting nexin 22 [Source:HGNC Symbol;Acc:HGNC:16315] GO:0005623|GO:0016020|GO:0005488|GO:0043229|GO:0043167|GO:0043227|GO:0008289|GO:0005622|GO:0031090|GO:0006810|GO:0043168|GO:0005543|GO:0031982|GO:0043231|GO:0005737|GO:0012506|GO:0045184|GO:0008104|GO:0031410|GO:0035091|GO:0015031|GO:0016023|GO:0031988|GO:0030659 cell|membrane|binding|intracellular organelle|ion binding|membrane-bounded organelle|lipid binding|intracellular|organelle membrane|transport|anion binding|phospholipid binding|vesicle|intracellular membrane-bounded organelle|cytoplasm|vesicle membrane|establishment of protein localization|protein localization|cytoplasmic vesicle|phosphatidylinositol binding|protein transport|cytoplasmic, membrane-bounded vesicle|membrane-bounded vesicle|cytoplasmic vesicle membrane - - - - 15:64151715-64157481 8 55 9 4 2 13 0.0336866593395238 0.210491251280313 0.0341688947370849 0.0150924759154268 0.0069096519716497 0.0513070438987462 0.0927822684523072 0.0244363905952742 1.92481791337043 0.0115925618088037 0.047124773997825 UP ENSG00000257336 PRELID2P1 PRELI domain containing 2 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:43892] - - - - - - 12:68957377-68957677 0 0 0 2 5 1 0 0 0 0.421135233268005 0.964119253235534 0.220218423181788 0 0.535157636561776 -Inf 0.0115964701536052 0.0471342436985336 DOWN ENSG00000258529 RP11-108O10.8 - GO:0016020|GO:0008152|GO:0003824|GO:0031224|GO:0016740|GO:0016757|GO:0016021 membrane|metabolic process|catalytic activity|intrinsic component of membrane|transferase activity|transferase activity, transferring glycosyl groups|integral component of membrane - - - - 11:111786286-111879425 2 18 2 0 1 2 0.0398948465584687 0.32633148263487 0.0359718285373455 0 0.0163742886588698 0.0373862072068348 0.134066052576895 0.0179201652885682 2.90328812324816 0.0116112306219527 0.0471878136384122 UP ENSG00000133116 KL klotho [Source:HGNC Symbol;Acc:HGNC:6344] GO:0040011|GO:0032502|GO:0004871|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0005576|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0036094|GO:1903561|GO:0051716|GO:0097159|GO:0050794|GO:0006950|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0009893|GO:0016787|GO:0031224|GO:0005615|GO:0050793|GO:0005622|GO:0002682|GO:0005515|GO:0005886|GO:0048856|GO:0019222|GO:0006935|GO:0045087|GO:0009888|GO:0048468|GO:0019838|GO:0007275|GO:0005496|GO:0048513|GO:0005102|GO:0016798|GO:0015980|GO:0006952|GO:0031982|GO:0031325|GO:0070169|GO:0005887|GO:0043178|GO:0010243|GO:0005975|GO:0006928|GO:0042592|GO:0009966|GO:0019842|GO:0010646|GO:0031226|GO:0043085|GO:0050776|GO:0007154|GO:0045778|GO:0007165|GO:0030278|GO:0070062|GO:0001503|GO:0009725|GO:0050790|GO:0030030|GO:0006091|GO:0048869|GO:0016021|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0055114|GO:0007568|GO:0071774|GO:0000165|GO:0030501|GO:1902533|GO:0032268|GO:0000902|GO:0031175|GO:0007166|GO:0070851|GO:0043412|GO:0048878|GO:0005179|GO:1901652|GO:0031214|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0005499|GO:0006112|GO:0032270|GO:0006796|GO:0004553|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:1902531|GO:0032870|GO:0017134|GO:0030282|GO:0030500|GO:0048666|GO:0030182|GO:0015926|GO:0007411|GO:0031401|GO:0008543|GO:0005104|GO:1901653|GO:0043408|GO:0090080|GO:0071363|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0048017|GO:0007167|GO:0071375|GO:0043410|GO:0050801|GO:0032868|GO:0004566|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0045859|GO:0048015|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0008422|GO:0001934|GO:0042327|GO:0007169|GO:0048010|GO:0055065|GO:0038095|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0007173|GO:0055074 locomotion|developmental process|signal transducer activity|immune system process|signaling|cell|membrane|cellular process|extracellular region|metabolic process|response to stimulus|binding|catalytic activity|small molecule binding|extracellular vesicle|cellular response to stimulus|organic cyclic compound binding|regulation of cellular process|response to stress|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|positive regulation of metabolic process|hydrolase activity|intrinsic component of membrane|extracellular space|regulation of developmental process|intracellular|regulation of immune system process|protein binding|plasma membrane|anatomical structure development|regulation of metabolic process|chemotaxis|innate immune response|tissue development|cell development|growth factor binding|multicellular organism development|steroid binding|animal organ development|receptor binding|hydrolase activity, acting on glycosyl bonds|energy derivation by oxidation of organic compounds|defense response|vesicle|positive regulation of cellular metabolic process|positive regulation of biomineral tissue development|integral component of plasma membrane|alcohol binding|response to organonitrogen compound|carbohydrate metabolic process|movement of cell or subcellular component|homeostatic process|regulation of signal transduction|vitamin binding|regulation of cell communication|intrinsic component of plasma membrane|positive regulation of catalytic activity|regulation of immune response|cell communication|positive regulation of ossification|signal transduction|regulation of ossification|extracellular exosome|ossification|response to hormone|regulation of catalytic activity|cell projection organization|generation of precursor metabolites and energy|cellular developmental process|integral component of membrane|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|oxidation-reduction process|aging|response to fibroblast growth factor|MAPK cascade|positive regulation of bone mineralization|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|neuron projection development|cell surface receptor signaling pathway|growth factor receptor binding|macromolecule modification|chemical homeostasis|hormone activity|response to peptide|biomineral tissue development|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|vitamin D binding|energy reserve metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|hydrolase activity, hydrolyzing O-glycosyl compounds|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|regulation of intracellular signal transduction|cellular response to hormone stimulus|fibroblast growth factor binding|bone mineralization|regulation of bone mineralization|neuron development|neuron differentiation|glucosidase activity|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|fibroblast growth factor receptor binding|cellular response to peptide|regulation of MAPK cascade|positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway|cellular response to growth factor stimulus|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|inositol lipid-mediated signaling|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|ion homeostasis|response to insulin|beta-glucuronidase activity|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|beta-glucosidase activity|positive regulation of protein phosphorylation|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|metal ion homeostasis|Fc-epsilon receptor signaling pathway|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway|calcium ion homeostasis K14756 klotho[3.2.1.31] hsa01100|hsa04211|hsa00500|hsa04961|hsa00040 Metabolic pathways - Homo sapiens (human)|Longevity regulating pathway - mammal - Homo sapiens (human)|Starch and sucrose metabolism - Homo sapiens (human)|Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)|Pentose and glucuronate interconversions - Homo sapiens (human) 13:33016433-33066145 0 0 0 4 0 5 0 0 0 0.0438621817348337 0 0.0573528103181648 0 0.0337383306843328 -Inf 0.011616390633465 0.047195934400036 DOWN ENSG00000279458 CH17-335B8.4 - - - - - - - 10:46370759-46382626 15 15 22 40 33 37 1.5742382413901 1.43077144783963 2.08167714476849 3.76137980127796 2.84165105548749 3.63925021658335 1.69556227799941 3.41409369111627 -1.00973887448146 0.0116227613086145 0.0472153920407373 DOWN ENSG00000139445 FOXN4 forkhead box N4 [Source:HGNC Symbol;Acc:HGNC:21399] GO:0032502|GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0044877|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0009653|GO:0043227|GO:0009893|GO:0009058|GO:0005622|GO:0048856|GO:0048646|GO:0019222|GO:0007507|GO:0035239|GO:0006725|GO:0060041|GO:0009888|GO:0035295|GO:1901360|GO:0036302|GO:0007275|GO:0003676|GO:0048513|GO:0034641|GO:0021517|GO:0031325|GO:0046483|GO:0043231|GO:0007389|GO:0007423|GO:0009887|GO:0003407|GO:0048729|GO:0048598|GO:0048568|GO:0003682|GO:0006139|GO:0010842|GO:0048869|GO:0044249|GO:0031323|GO:0003013|GO:0003677|GO:0003143|GO:0010468|GO:0034645|GO:0001654|GO:0002009|GO:0072358|GO:0007417|GO:0051252|GO:0035050|GO:0021510|GO:0003007|GO:0035881|GO:0009790|GO:0010628|GO:0003002|GO:0060042|GO:0021514|GO:0061371|GO:0060429|GO:0010467|GO:0048562|GO:0007399|GO:0060562|GO:0031328|GO:0009059|GO:0030154|GO:0016070|GO:0072359|GO:0008015|GO:0010557|GO:0005634|GO:0045165|GO:0030182|GO:0008016|GO:0021953|GO:0000975|GO:0045893|GO:0043010|GO:0032774|GO:0043565|GO:0060047|GO:2001141|GO:0021515|GO:0003690|GO:0048663|GO:0001947|GO:0009855|GO:0009953|GO:0021511|GO:0022008|GO:0060579|GO:0006351|GO:0006355|GO:0048592|GO:0021513|GO:0048593|GO:0048699|GO:0007368|GO:1903506|GO:0044212|GO:0035326|GO:0000976|GO:0001158 developmental process|cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|macromolecular complex binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|anatomical structure morphogenesis|membrane-bounded organelle|positive regulation of metabolic process|biosynthetic process|intracellular|anatomical structure development|anatomical structure formation involved in morphogenesis|regulation of metabolic process|heart development|tube morphogenesis|cellular aromatic compound metabolic process|retina development in camera-type eye|tissue development|tube development|organic cyclic compound metabolic process|atrioventricular canal development|multicellular organism development|nucleic acid binding|animal organ development|cellular nitrogen compound metabolic process|ventral spinal cord development|positive regulation of cellular metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|pattern specification process|sensory organ development|organ morphogenesis|neural retina development|tissue morphogenesis|embryonic morphogenesis|embryonic organ development|chromatin binding|nucleobase-containing compound metabolic process|retina layer formation|cellular developmental process|cellular biosynthetic process|regulation of cellular metabolic process|circulatory system process|DNA binding|embryonic heart tube morphogenesis|regulation of gene expression|cellular macromolecule biosynthetic process|eye development|morphogenesis of an epithelium|cardiovascular system development|central nervous system development|regulation of RNA metabolic process|embryonic heart tube development|spinal cord development|heart morphogenesis|amacrine cell differentiation|embryo development|positive regulation of gene expression|regionalization|retina morphogenesis in camera-type eye|ventral spinal cord interneuron differentiation|determination of heart left/right asymmetry|epithelium development|gene expression|embryonic organ morphogenesis|nervous system development|epithelial tube morphogenesis|positive regulation of cellular biosynthetic process|macromolecule biosynthetic process|cell differentiation|RNA metabolic process|circulatory system development|blood circulation|positive regulation of macromolecule biosynthetic process|nucleus|cell fate commitment|neuron differentiation|regulation of heart contraction|central nervous system neuron differentiation|regulatory region DNA binding|positive regulation of transcription, DNA-templated|camera-type eye development|RNA biosynthetic process|sequence-specific DNA binding|heart contraction|regulation of RNA biosynthetic process|cell differentiation in spinal cord|double-stranded DNA binding|neuron fate commitment|heart looping|determination of bilateral symmetry|dorsal/ventral pattern formation|spinal cord patterning|neurogenesis|ventral spinal cord interneuron fate commitment|transcription, DNA-templated|regulation of transcription, DNA-templated|eye morphogenesis|spinal cord dorsal/ventral patterning|camera-type eye morphogenesis|generation of neurons|determination of left/right symmetry|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|enhancer binding|transcription regulatory region sequence-specific DNA binding|enhancer sequence-specific DNA binding - - - - 12:109277979-109309220 0 0 0 5 0 4 0 0 0 0.0422214795373952 0 0.0353288449714687 0 0.0258501081696213 -Inf 0.0116355270522303 0.0472455911756561 DOWN ENSG00000139874 SSTR1 somatostatin receptor 1 [Source:HGNC Symbol;Acc:HGNC:11330] GO:0032502|GO:0004871|GO:0000003|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0022414|GO:0050896|GO:0005488|GO:0051716|GO:0042995|GO:0033218|GO:0004872|GO:0048523|GO:0008283|GO:0050794|GO:0006950|GO:0044702|GO:0019953|GO:0038023|GO:0071944|GO:0009605|GO:0032504|GO:0031224|GO:0005622|GO:0005515|GO:0005886|GO:0048856|GO:0048609|GO:0042127|GO:0042277|GO:0009991|GO:0007275|GO:0048513|GO:0030902|GO:0030900|GO:0007420|GO:0005887|GO:0010243|GO:0004888|GO:0005737|GO:0007267|GO:0060322|GO:0043005|GO:0031226|GO:0007154|GO:0022037|GO:0007276|GO:0007165|GO:0007586|GO:0009725|GO:0008285|GO:0021549|GO:0016021|GO:0010033|GO:0042594|GO:0007584|GO:0007186|GO:0048232|GO:0007166|GO:0033993|GO:0007417|GO:0042923|GO:1901652|GO:0071417|GO:0043434|GO:0014070|GO:0007399|GO:0071310|GO:0009755|GO:0008528|GO:0031667|GO:0004930|GO:0032870|GO:0048545|GO:0097305|GO:0007283|GO:0007187|GO:0007215|GO:1901653|GO:0043627|GO:0071383|GO:0071407|GO:0071375|GO:0008188|GO:0032355|GO:0007218|GO:0038170|GO:0071396|GO:0004994|GO:0071392|GO:0071391 developmental process|signal transducer activity|reproduction|signaling|cell|membrane|cellular process|reproductive process|response to stimulus|binding|cellular response to stimulus|cell projection|amide binding|receptor activity|negative regulation of cellular process|cell proliferation|regulation of cellular process|response to stress|single organism reproductive process|sexual reproduction|signaling receptor activity|cell periphery|response to external stimulus|multicellular organism reproduction|intrinsic component of membrane|intracellular|protein binding|plasma membrane|anatomical structure development|multicellular organismal reproductive process|regulation of cell proliferation|peptide binding|response to extracellular stimulus|multicellular organism development|animal organ development|hindbrain development|forebrain development|brain development|integral component of plasma membrane|response to organonitrogen compound|transmembrane signaling receptor activity|cytoplasm|cell-cell signaling|head development|neuron projection|intrinsic component of plasma membrane|cell communication|metencephalon development|gamete generation|signal transduction|digestion|response to hormone|negative regulation of cell proliferation|cerebellum development|integral component of membrane|response to organic substance|response to starvation|response to nutrient|G-protein coupled receptor signaling pathway|male gamete generation|cell surface receptor signaling pathway|response to lipid|central nervous system development|neuropeptide binding|response to peptide|cellular response to organonitrogen compound|response to peptide hormone|response to organic cyclic compound|nervous system development|cellular response to organic substance|hormone-mediated signaling pathway|G-protein coupled peptide receptor activity|response to nutrient levels|G-protein coupled receptor activity|cellular response to hormone stimulus|response to steroid hormone|response to alcohol|spermatogenesis|G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|glutamate receptor signaling pathway|cellular response to peptide|response to estrogen|cellular response to steroid hormone stimulus|cellular response to organic cyclic compound|cellular response to peptide hormone stimulus|neuropeptide receptor activity|response to estradiol|neuropeptide signaling pathway|somatostatin signaling pathway|cellular response to lipid|somatostatin receptor activity|cellular response to estradiol stimulus|cellular response to estrogen stimulus K04217 somatostatin receptor 1[-] hsa04080|hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human)|cAMP signaling pathway - Homo sapiens (human) 14:38207999-38213067 0 0 0 5 0 4 0 0 0 0.0737769974221539 0 0.0617329409804126 0 0.0451699794675222 -Inf 0.0116331441934907 0.0472455911756561 DOWN ENSG00000168928 CTRB2 chymotrypsinogen B2 [Source:HGNC Symbol;Acc:HGNC:2522] GO:0009987|GO:0005576|GO:0008152|GO:0003824|GO:0006807|GO:0071704|GO:0044237|GO:0016043|GO:0016787|GO:0005615|GO:0006725|GO:1901360|GO:0043062|GO:0044281|GO:0046483|GO:0008233|GO:0007586|GO:0009235|GO:0019538|GO:0017171|GO:0022617|GO:0006508|GO:0008236|GO:0030198|GO:0006766|GO:0004252|GO:0004175|GO:0006767 cellular process|extracellular region|metabolic process|catalytic activity|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|cellular component organization|hydrolase activity|extracellular space|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|extracellular structure organization|small molecule metabolic process|heterocycle metabolic process|peptidase activity|digestion|cobalamin metabolic process|protein metabolic process|serine hydrolase activity|extracellular matrix disassembly|proteolysis|serine-type peptidase activity|extracellular matrix organization|vitamin metabolic process|serine-type endopeptidase activity|endopeptidase activity|water-soluble vitamin metabolic process - - - - 16:75204096-75207185 7 12 10 1 1 7 0.11667485181706 0.181773709931393 0.150278162103472 0.0149266714186645 0.0136812506089426 0.109347486897839 0.149575574617308 0.045985136308482 1.70163508338582 0.0116381080426668 0.0472455911756561 UP ENSG00000248560 CTB-14A14.2 - - - - - - - 5:181114106-181115674 0 0 0 0 4 5 0 0 0 0 0.147951987023291 0.211280588680046 0 0.119744191901112 -Inf 0.0116360307170646 0.0472455911756561 DOWN ENSG00000162188 GNG3 guanine nucleotide binding protein (G protein), gamma 3 [Source:HGNC Symbol;Acc:HGNC:4405] GO:0032991|GO:0004871|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0003824|GO:0051716|GO:0019898|GO:0042995|GO:0050794|GO:0060076|GO:0043229|GO:0071704|GO:0044237|GO:0023051|GO:0044297|GO:0071944|GO:0009893|GO:0016787|GO:0005622|GO:0005515|GO:0005886|GO:0043234|GO:0019222|GO:0009898|GO:0098797|GO:0005102|GO:0015980|GO:0044281|GO:0031325|GO:0016817|GO:0010243|GO:0005737|GO:0007267|GO:0042592|GO:0031234|GO:0098562|GO:0043005|GO:0009966|GO:0019897|GO:0019725|GO:0036477|GO:0097481|GO:0014069|GO:0010646|GO:0043085|GO:0007154|GO:0007165|GO:0009725|GO:0005834|GO:0050790|GO:0006091|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0055114|GO:0000165|GO:1902533|GO:0032268|GO:0005829|GO:0007186|GO:0043412|GO:0048878|GO:1901652|GO:0071417|GO:0016818|GO:0051347|GO:0036211|GO:0055082|GO:0043434|GO:0030425|GO:0051247|GO:0001664|GO:0006112|GO:0032270|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0071310|GO:0051246|GO:1902531|GO:0032870|GO:0031401|GO:1901653|GO:0043408|GO:0016310|GO:0071375|GO:0043410|GO:0050801|GO:0006464|GO:0033762|GO:0031701|GO:0016462|GO:0043549|GO:0006873|GO:0033674|GO:0071377|GO:0045859|GO:0045860|GO:0043406|GO:0006468|GO:0017111|GO:0043405|GO:0042325|GO:0001932|GO:0001934|GO:0031702|GO:0030003|GO:0042327|GO:0007268|GO:0000187|GO:0055065|GO:0071902|GO:0006875|GO:0003924|GO:0071900|GO:0032147|GO:0006874|GO:0055074|GO:0051480|GO:0007204 macromolecular complex|signal transducer activity|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|catalytic activity|cellular response to stimulus|extrinsic component of membrane|cell projection|regulation of cellular process|excitatory synapse|intracellular organelle|organic substance metabolic process|cellular metabolic process|regulation of signaling|cell body|cell periphery|positive regulation of metabolic process|hydrolase activity|intracellular|protein binding|plasma membrane|protein complex|regulation of metabolic process|cytoplasmic side of plasma membrane|plasma membrane protein complex|receptor binding|energy derivation by oxidation of organic compounds|small molecule metabolic process|positive regulation of cellular metabolic process|hydrolase activity, acting on acid anhydrides|response to organonitrogen compound|cytoplasm|cell-cell signaling|homeostatic process|extrinsic component of cytoplasmic side of plasma membrane|cytoplasmic side of membrane|neuron projection|regulation of signal transduction|extrinsic component of plasma membrane|cellular homeostasis|somatodendritic compartment|neuronal postsynaptic density|postsynaptic density|regulation of cell communication|positive regulation of catalytic activity|cell communication|signal transduction|response to hormone|heterotrimeric G-protein complex|regulation of catalytic activity|generation of precursor metabolites and energy|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|oxidation-reduction process|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cytosol|G-protein coupled receptor signaling pathway|macromolecule modification|chemical homeostasis|response to peptide|cellular response to organonitrogen compound|hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides|positive regulation of transferase activity|protein modification process|cellular chemical homeostasis|response to peptide hormone|dendrite|positive regulation of protein metabolic process|G-protein coupled receptor binding|energy reserve metabolic process|positive regulation of cellular protein metabolic process|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cellular response to organic substance|regulation of protein metabolic process|regulation of intracellular signal transduction|cellular response to hormone stimulus|positive regulation of protein modification process|cellular response to peptide|regulation of MAPK cascade|phosphorylation|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|ion homeostasis|cellular protein modification process|response to glucagon|angiotensin receptor binding|pyrophosphatase activity|regulation of kinase activity|cellular ion homeostasis|positive regulation of kinase activity|cellular response to glucagon stimulus|regulation of protein kinase activity|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|protein phosphorylation|nucleoside-triphosphatase activity|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|positive regulation of protein phosphorylation|type 1 angiotensin receptor binding|cellular cation homeostasis|positive regulation of phosphorylation|synaptic transmission|activation of MAPK activity|metal ion homeostasis|positive regulation of protein serine/threonine kinase activity|cellular metal ion homeostasis|GTPase activity|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|cellular calcium ion homeostasis|calcium ion homeostasis|regulation of cytosolic calcium ion concentration|positive regulation of cytosolic calcium ion concentration K04540 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3[-] hsa05200|hsa04151|hsa04014|hsa04062|hsa05034|hsa04728|hsa04724|hsa04726|hsa04725|hsa04723|hsa04713|hsa05032|hsa04727 Pathways in cancer - Homo sapiens (human)|PI3K-Akt signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Chemokine signaling pathway - Homo sapiens (human)|Alcoholism - Homo sapiens (human)|Dopaminergic synapse - Homo sapiens (human)|Glutamatergic synapse - Homo sapiens (human)|Serotonergic synapse - Homo sapiens (human)|Cholinergic synapse - Homo sapiens (human)|Retrograde endocannabinoid signaling - Homo sapiens (human)|Circadian entrainment - Homo sapiens (human)|Morphine addiction - Homo sapiens (human)|GABAergic synapse - Homo sapiens (human) 11:62707658-62709201 16 29 17 10 11 10 1.28322365999948 2.11378932534114 1.22924434213975 0.718603771052548 0.723815075604547 0.751619014203609 1.54208577582679 0.731345953620235 1.07625709413799 0.0116921409764908 0.0474133627699209 UP ENSG00000171649 ZIK1 zinc finger protein interacting with K protein 1 [Source:HGNC Symbol;Acc:HGNC:33104] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0000975|GO:0032774|GO:0043565|GO:2001141|GO:0003690|GO:0006351|GO:0006355|GO:1903506|GO:0044212|GO:0000976|GO:0001012|GO:0000977 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|regulatory region DNA binding|RNA biosynthetic process|sequence-specific DNA binding|regulation of RNA biosynthetic process|double-stranded DNA binding|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription|transcription regulatory region DNA binding|transcription regulatory region sequence-specific DNA binding|RNA polymerase II regulatory region DNA binding|RNA polymerase II regulatory region sequence-specific DNA binding - - - - 19:57578456-57593777 6 11 5 1 1 4 0.0446785322338131 0.0744489680521775 0.0335674161287187 0.00666899605230151 0.00611256212068138 0.0279127257091138 0.0508983054715698 0.0135647612940322 1.90775396626377 0.0117133026941828 0.0474733829258939 UP ENSG00000106686 SPATA6L spermatogenesis associated 6-like [Source:HGNC Symbol;Acc:HGNC:25472] - - - - - - 9:4553386-4666674 3 8 7 12 21 17 0.0205235295734401 0.0497339151564216 0.043169228295148 0.0735490021547255 0.117861395138865 0.108983532049319 0.0378088910083366 0.10013130978097 -1.40509571837789 0.0117159362878323 0.0474776112307512 DOWN ENSG00000277745 H2AFB3 H2A histone family member B3 [Source:HGNC Symbol;Acc:HGNC:14455] GO:0032991|GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0097159|GO:0009892|GO:0048523|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0044237|GO:0000785|GO:0016043|GO:0043227|GO:0009058|GO:0032993|GO:0005622|GO:0005515|GO:0043234|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0022607|GO:0043231|GO:0046983|GO:0009890|GO:0016458|GO:0006139|GO:0000790|GO:0035327|GO:0044249|GO:0000786|GO:0031324|GO:0031323|GO:0006996|GO:0051276|GO:0003677|GO:0010468|GO:0034645|GO:0010629|GO:0046982|GO:0051252|GO:0006325|GO:0000788|GO:0031981|GO:0005694|GO:0000228|GO:0006461|GO:0006342|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0045814|GO:0006334|GO:0034622|GO:0006396|GO:0045892|GO:0032774|GO:2001141|GO:0034728|GO:1902679|GO:0040029|GO:0006333|GO:0016071|GO:0065004|GO:0031497|GO:0071103|GO:0006351|GO:0006355|GO:0006323|GO:1903507|GO:1903506|GO:0006397 macromolecular complex|cell|cellular process|metabolic process|binding|organic cyclic compound binding|negative regulation of metabolic process|negative regulation of cellular process|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|cellular metabolic process|chromatin|cellular component organization|membrane-bounded organelle|biosynthetic process|protein-DNA complex|intracellular|protein binding|protein complex|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|cellular component assembly|intracellular membrane-bounded organelle|protein dimerization activity|negative regulation of biosynthetic process|gene silencing|nucleobase-containing compound metabolic process|nuclear chromatin|transcriptionally active chromatin|cellular biosynthetic process|nucleosome|negative regulation of cellular metabolic process|regulation of cellular metabolic process|organelle organization|chromosome organization|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|negative regulation of gene expression|protein heterodimerization activity|regulation of RNA metabolic process|chromatin organization|nuclear nucleosome|nuclear lumen|chromosome|nuclear chromosome|protein complex assembly|chromatin silencing|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|negative regulation of gene expression, epigenetic|nucleosome assembly|cellular macromolecular complex assembly|RNA processing|negative regulation of transcription, DNA-templated|RNA biosynthetic process|regulation of RNA biosynthetic process|nucleosome organization|negative regulation of RNA biosynthetic process|regulation of gene expression, epigenetic|chromatin assembly or disassembly|mRNA metabolic process|protein-DNA complex assembly|chromatin assembly|DNA conformation change|transcription, DNA-templated|regulation of transcription, DNA-templated|DNA packaging|negative regulation of nucleic acid-templated transcription|regulation of nucleic acid-templated transcription|mRNA processing K11251 histone H2A[-] hsa05034|hsa05322 Alcoholism - Homo sapiens (human)|Systemic lupus erythematosus - Homo sapiens (human) X:155459415-155460005 3 2 3 9 14 7 0.359109677358619 0.21755432175658 0.323689986147668 0.965136403308781 1.37485018288889 0.785229669026106 0.300117995087622 1.04173875174126 -1.79539179181 0.0117511696734261 0.0475751857106678 DOWN ENSG00000186998 EMID1 EMI domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18036] GO:0031012|GO:0032991|GO:0005623|GO:0005576|GO:0005488|GO:0043229|GO:0005578|GO:0043227|GO:0005622|GO:0005515|GO:0043234|GO:0012505|GO:0043231|GO:0005737|GO:0005783|GO:0005581|GO:0005794 extracellular matrix|macromolecular complex|cell|extracellular region|binding|intracellular organelle|proteinaceous extracellular matrix|membrane-bounded organelle|intracellular|protein binding|protein complex|endomembrane system|intracellular membrane-bounded organelle|cytoplasm|endoplasmic reticulum|collagen trimer|Golgi apparatus - - - - 22:29205851-29259597 1 1 4 5 6 14 0.0103008287369161 0.00936211451774954 0.03713423697043 0.0461240471511137 0.0506848619300313 0.135100650478727 0.0189323934083652 0.0773031865199573 -2.02967107861969 0.0117652513608805 0.0476257375088441 DOWN ENSG00000167555 ZNF528 zinc finger protein 528 [Source:HGNC Symbol;Acc:HGNC:29384] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 19:52397849-52418412 18 10 29 39 40 47 0.0733661995975724 0.0370425249663322 0.106570448500595 0.142423340498328 0.133767850212747 0.179536337266215 0.0723263910214999 0.15190917599243 -1.0706149474433 0.011785747135889 0.047680639973373 DOWN ENSG00000165507 C10orf10 chromosome 10 open reading frame 10 [Source:HGNC Symbol;Acc:HGNC:23355] GO:0005623|GO:0043229|GO:0043227|GO:0005622|GO:0043231|GO:0005737|GO:0005739 cell|intracellular organelle|membrane-bounded organelle|intracellular|intracellular membrane-bounded organelle|cytoplasm|mitochondrion - - - - 10:44970981-44978810 129 145 257 235 214 811 2.53403507816749 2.58863905196416 4.55165939984895 4.13607872147065 3.44909290167997 14.9304385196801 3.22477784332687 7.50520338094357 -1.21869139155099 0.0118087893611351 0.0477437158162688 DOWN ENSG00000113319 RASGRF2 Ras protein specific guanine nucleotide releasing factor 2 [Source:HGNC Symbol;Acc:HGNC:9876] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0051716|GO:0050794|GO:0043229|GO:0006950|GO:0042175|GO:0071704|GO:0006955|GO:0044237|GO:0023051|GO:0009653|GO:0016043|GO:0043227|GO:0071944|GO:0009605|GO:0009893|GO:0005622|GO:0002682|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0005085|GO:0048856|GO:0031090|GO:0019222|GO:0006935|GO:0045087|GO:0048468|GO:0010941|GO:0007275|GO:0006952|GO:0031325|GO:0010942|GO:0043231|GO:0010243|GO:0005737|GO:0007267|GO:0005088|GO:0006928|GO:0009966|GO:0010646|GO:0043085|GO:0050776|GO:0005516|GO:0007154|GO:0007165|GO:0005783|GO:0009725|GO:0008219|GO:0050790|GO:0030030|GO:0048869|GO:0009967|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0071774|GO:0000165|GO:1902533|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0007166|GO:0043412|GO:0051345|GO:1901652|GO:0000904|GO:0071417|GO:0051347|GO:0036211|GO:0043434|GO:0044344|GO:0051247|GO:0070848|GO:0002764|GO:0032270|GO:0012501|GO:0006796|GO:0035556|GO:0044267|GO:0051174|GO:0032990|GO:0007399|GO:0071310|GO:0097485|GO:0051246|GO:0030154|GO:0048858|GO:0005089|GO:0043068|GO:1902531|GO:0032870|GO:0043067|GO:0097190|GO:0048666|GO:0030182|GO:0007411|GO:0031401|GO:0008543|GO:0043065|GO:1901653|GO:0043408|GO:0071363|GO:0043087|GO:0016310|GO:0002768|GO:0038179|GO:0061564|GO:0043547|GO:0007167|GO:0071375|GO:0043410|GO:0042981|GO:0032868|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0048812|GO:0043549|GO:0006915|GO:0033674|GO:0048011|GO:0000186|GO:0007265|GO:0046578|GO:0045859|GO:0045860|GO:0007409|GO:0006468|GO:0048699|GO:0043405|GO:0042325|GO:0001932|GO:0032869|GO:0038093|GO:0001934|GO:0042327|GO:0007268|GO:0007169|GO:0048010|GO:0038095|GO:0035023|GO:0071900|GO:0007266|GO:0032147|GO:0008286|GO:0038127|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|cellular response to stimulus|regulation of cellular process|intracellular organelle|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|immune response|cellular metabolic process|regulation of signaling|anatomical structure morphogenesis|cellular component organization|membrane-bounded organelle|cell periphery|response to external stimulus|positive regulation of metabolic process|intracellular|regulation of immune system process|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|guanyl-nucleotide exchange factor activity|anatomical structure development|organelle membrane|regulation of metabolic process|chemotaxis|innate immune response|cell development|regulation of cell death|multicellular organism development|defense response|positive regulation of cellular metabolic process|positive regulation of cell death|intracellular membrane-bounded organelle|response to organonitrogen compound|cytoplasm|cell-cell signaling|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|regulation of signal transduction|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|calmodulin binding|cell communication|signal transduction|endoplasmic reticulum|response to hormone|cell death|regulation of catalytic activity|cell projection organization|cellular developmental process|positive regulation of signal transduction|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|response to fibroblast growth factor|MAPK cascade|positive regulation of intracellular signal transduction|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|cell surface receptor signaling pathway|macromolecule modification|positive regulation of hydrolase activity|response to peptide|cell morphogenesis involved in differentiation|cellular response to organonitrogen compound|positive regulation of transferase activity|protein modification process|response to peptide hormone|cellular response to fibroblast growth factor stimulus|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|positive regulation of cellular protein metabolic process|programmed cell death|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|regulation of phosphorus metabolic process|cell part morphogenesis|nervous system development|cellular response to organic substance|neuron projection guidance|regulation of protein metabolic process|cell differentiation|cell projection morphogenesis|Rho guanyl-nucleotide exchange factor activity|positive regulation of programmed cell death|regulation of intracellular signal transduction|cellular response to hormone stimulus|regulation of programmed cell death|apoptotic signaling pathway|neuron development|neuron differentiation|axon guidance|positive regulation of protein modification process|fibroblast growth factor receptor signaling pathway|positive regulation of apoptotic process|cellular response to peptide|regulation of MAPK cascade|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|axon development|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|cellular response to peptide hormone stimulus|positive regulation of MAPK cascade|regulation of apoptotic process|response to insulin|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|neuron projection morphogenesis|regulation of kinase activity|apoptotic process|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|activation of MAPKK activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|positive regulation of protein kinase activity|axonogenesis|protein phosphorylation|generation of neurons|regulation of MAP kinase activity|regulation of phosphorylation|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of protein phosphorylation|positive regulation of phosphorylation|synaptic transmission|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|Fc-epsilon receptor signaling pathway|regulation of Rho protein signal transduction|regulation of protein serine/threonine kinase activity|Rho protein signal transduction|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|epidermal growth factor receptor signaling pathway K12326 Ras-specific guanine nucleotide-releasing factor 2[-] hsa04010|hsa04014 MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human) 5:80960672-81230156 13 7 12 34 20 24 0.081126550401464 0.0397037087967672 0.0675197727358238 0.190108943133686 0.102403304768121 0.140367837610625 0.0627833439780183 0.144293361837477 -1.20055115353838 0.0118181610280524 0.0477691358498789 DOWN ENSG00000279342 AP000866.1 - - - - - - - 11:124789244-124790069 4 5 12 18 16 22 0.342535413792567 0.389185151396147 0.926557656126588 1.38110318245881 1.12421887640086 1.76573601520703 0.552759407105101 1.4236860246889 -1.36490743609422 0.0118488639616061 0.0478798030197331 DOWN ENSG00000236137 RP11-27K13.3 - - - - - - - 1:117025482-117059490 15 24 15 46 53 25 0.435565096345207 0.633372434276547 0.392708294652641 1.19679432819799 1.26273163831905 0.680359271220919 0.487215275091465 1.04662841257932 -1.10311805890677 0.0119057167159456 0.0481030270453161 DOWN ENSG00000258465 RP11-574F21.3 - GO:0005623|GO:0005488|GO:0043229|GO:0043227|GO:0005622|GO:0005515|GO:0043231|GO:0005737|GO:0005777 cell|binding|intracellular organelle|membrane-bounded organelle|intracellular|protein binding|intracellular membrane-bounded organelle|cytoplasm|peroxisome - - - - 1:160217464-160285130 4 4 47 4 5 4 0.0911514986445426 0.0828444614420999 0.965679227227747 0.0816763564521066 0.0934922342860489 0.0854197749712862 0.379891729104797 0.0868627885698139 2.12877812868222 0.011917990013187 0.0481460993036108 UP ENSG00000261251 RP3-388M5.9 - - - - - - - 22:43812456-43817394 1 2 7 12 8 12 0.0304766121544418 0.0553723532119461 0.192253656244671 0.327549625875115 0.19997048089062 0.342592360587002 0.092700873870353 0.290037489117579 -1.64558454545149 0.0119990915577674 0.0484278598574539 DOWN ENSG00000278918 CTD-2267D19.1 - - - - - - - 17:40348049-40350539 12 12 14 7 5 5 0.340774394350413 0.309693948193028 0.358447502189478 0.178094704593264 0.116499355770331 0.13307878106744 0.33630528157764 0.142557613810345 1.23822634241815 0.0120130370459395 0.048471037703673 UP ENSG00000214076 CPSF1P1 cleavage and polyadenylation specific factor 1 pseudogene 1 [Source:HGNC Symbol;Acc:HGNC:19251] - - - - - - 22:32269381-32273110 2 4 6 12 6 22 0.0379268434038419 0.0689408065191094 0.102592040745384 0.203906228225742 0.0933525473081273 0.391018216772387 0.0698198968894451 0.229425664102085 -1.71631665226776 0.0120307832292104 0.048529523378577 DOWN ENSG00000173258 ZNF483 zinc finger protein 483 [Source:HGNC Symbol;Acc:HGNC:23384] GO:0005623|GO:0009987|GO:0008152|GO:0001071|GO:0005488|GO:0097159|GO:0003700|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:1903506 cell|cellular process|metabolic process|nucleic acid binding transcription factor activity|binding|organic cyclic compound binding|transcription factor activity, sequence-specific DNA binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|regulation of nucleic acid-templated transcription - - - - 9:111525159-111577844 31 58 92 30 19 43 0.341085680948276 0.579975660380468 0.912653178875434 0.295747621713018 0.171525331048566 0.443403271892034 0.611238173401393 0.303558741551206 1.00975892728186 0.0120486740804857 0.0485885608535485 UP ENSG00000124467 PSG8 pregnancy specific beta-1-glycoprotein 8 [Source:HGNC Symbol;Acc:HGNC:9525] GO:0005576|GO:0005488|GO:0005515 extracellular region|binding|protein binding - - - - 19:42752686-42855691 2 3 9 0 1 1 0.0148117606424804 0.0201960350638759 0.0600951831005709 0 0.00607928254469191 0.00694018902499404 0.0317009929356424 0.00433982385656198 2.86881963572899 0.0120895924730573 0.048740404279629 UP ENSG00000249007 RP11-510N19.5 - - - - - - - 1:202011370-202015657 23 15 41 12 9 17 1.64840054633348 0.977041495282586 2.64924013103814 0.770587873639328 0.529216375748165 1.14184265949545 1.75822739088474 0.813882302960981 1.11122958188759 0.0122102399802486 0.0491471625145396 UP ENSG00000244055 AC007566.10 - - - - - - - 7:92457564-92491610 3 1 5 6 10 14 0.20446418046141 0.0619631278775909 0.307183897694315 0.366363309866097 0.559152013918874 0.894163264729149 0.191203735344439 0.606559529504707 -1.66553853455811 0.0122139743169355 0.0491555660902927 DOWN ENSG00000258878 CTD-2509G16.3 - - - - - - - 14:65234515-65235101 0 2 2 13 2 7 0 0.219036804357988 0.217301710380625 1.40360992296904 0.197731403440838 0.790580467452178 0.145446171579538 0.797307264620685 -2.45465049174426 0.012242884529474 0.0492453617276902 DOWN ENSG00000204941 PSG5 pregnancy specific beta-1-glycoprotein 5 [Source:HGNC Symbol;Acc:HGNC:9522] GO:0000003|GO:0005576|GO:0022414|GO:0005488|GO:0005515|GO:0007565 reproduction|extracellular region|reproductive process|binding|protein binding|female pregnancy - - - - 19:43166256-43186536 11 27 49 13 11 15 0.102274227511076 0.228152941744578 0.410755050645157 0.108296401785335 0.0839123155472149 0.130708098602336 0.247060739966937 0.107638938644962 1.19866570176597 0.0122470714956804 0.0492555668101902 UP ENSG00000265437 RP11-757O6.4 - - - - - - - 18:14361434-14361943 16 17 14 7 11 5 2.21922209435204 2.14296972549422 1.75077005481174 0.869870410082001 1.25177430722198 0.649998516939201 2.03765395821933 0.923881078081061 1.14113000352159 0.0122939080504345 0.0494106530610757 UP ENSG00000182983 ZNF662 zinc finger protein 662 [Source:HGNC Symbol;Acc:HGNC:31930] GO:0005623|GO:0009987|GO:0008152|GO:0005488|GO:0000988|GO:0097159|GO:0050794|GO:0043229|GO:0006807|GO:0071704|GO:0043167|GO:0044237|GO:0000989|GO:0043227|GO:0009058|GO:0005622|GO:0005515|GO:0019222|GO:0003712|GO:0006725|GO:1901360|GO:0003676|GO:0034641|GO:0046483|GO:0043231|GO:0043169|GO:0006139|GO:0044249|GO:0031323|GO:0003677|GO:0010468|GO:0034645|GO:0046872|GO:0051252|GO:0010467|GO:0009059|GO:0016070|GO:0005634|GO:0032774|GO:2001141|GO:0006351|GO:0006355|GO:0006366|GO:0006357|GO:1903506 cell|cellular process|metabolic process|binding|transcription factor activity, protein binding|organic cyclic compound binding|regulation of cellular process|intracellular organelle|nitrogen compound metabolic process|organic substance metabolic process|ion binding|cellular metabolic process|transcription factor activity, transcription factor binding|membrane-bounded organelle|biosynthetic process|intracellular|protein binding|regulation of metabolic process|transcription cofactor activity|cellular aromatic compound metabolic process|organic cyclic compound metabolic process|nucleic acid binding|cellular nitrogen compound metabolic process|heterocycle metabolic process|intracellular membrane-bounded organelle|cation binding|nucleobase-containing compound metabolic process|cellular biosynthetic process|regulation of cellular metabolic process|DNA binding|regulation of gene expression|cellular macromolecule biosynthetic process|metal ion binding|regulation of RNA metabolic process|gene expression|macromolecule biosynthetic process|RNA metabolic process|nucleus|RNA biosynthetic process|regulation of RNA biosynthetic process|transcription, DNA-templated|regulation of transcription, DNA-templated|transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter|regulation of nucleic acid-templated transcription - - - - 3:42905731-42917641 6 9 17 22 22 33 0.0432444851934981 0.0589582375554815 0.110474170548936 0.14207404107788 0.130106777533662 0.222917430656848 0.0708922977659719 0.16503274975613 -1.21905155039813 0.0123026639747681 0.0494258821562007 DOWN ENSG00000172575 RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) [Source:HGNC Symbol;Acc:HGNC:9878] GO:0040011|GO:0032502|GO:0002376|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0036094|GO:0051716|GO:0050794|GO:0045321|GO:0001909|GO:0043229|GO:0051050|GO:0006950|GO:0042175|GO:0071704|GO:0043167|GO:0006955|GO:0044237|GO:0051641|GO:0023051|GO:0009653|GO:0072341|GO:0016043|GO:0007155|GO:0043227|GO:0008289|GO:0071944|GO:0009605|GO:0009893|GO:0002684|GO:0042267|GO:0050793|GO:0005622|GO:0002682|GO:0002520|GO:0005789|GO:0005515|GO:0005886|GO:0012505|GO:0005085|GO:0048856|GO:0031090|GO:0019222|GO:0042802|GO:0060341|GO:1903706|GO:0031210|GO:0050817|GO:0016337|GO:0006935|GO:0045087|GO:0045595|GO:0051640|GO:0048468|GO:0050867|GO:0006810|GO:0007275|GO:0048513|GO:0070489|GO:0043168|GO:0032940|GO:0006952|GO:0030155|GO:0005543|GO:0031325|GO:0033554|GO:0022607|GO:0001817|GO:0098609|GO:0045597|GO:0043231|GO:0043178|GO:0002437|GO:0043169|GO:0010243|GO:0005737|GO:0001816|GO:0001910|GO:0001912|GO:0009611|GO:0032880|GO:0042269|GO:0051222|GO:0005088|GO:0006928|GO:0051656|GO:0043177|GO:0019992|GO:0002696|GO:0001775|GO:0009966|GO:0046983|GO:0002263|GO:0045184|GO:0001819|GO:0010646|GO:0043085|GO:0050776|GO:0008104|GO:0046649|GO:0050865|GO:0001786|GO:0007154|GO:0010970|GO:0007165|GO:0002366|GO:0050778|GO:0005783|GO:0051649|GO:0045785|GO:0009725|GO:0051047|GO:0050790|GO:0030030|GO:0043299|GO:0048869|GO:0009967|GO:0045954|GO:0007017|GO:0019538|GO:0023014|GO:0010033|GO:0031323|GO:0050878|GO:0005794|GO:0002443|GO:0071774|GO:0000165|GO:0016192|GO:1902533|GO:0051650|GO:0051249|GO:0032268|GO:0000902|GO:0005829|GO:0031175|GO:0030168|GO:0030101|GO:0046872|GO:0007166|GO:0043412|GO:0030097|GO:0030098|GO:0051345|GO:0007596|GO:0043303|GO:0034109|GO:0051223|GO:0015031|GO:1901652|GO:0002228|GO:0000904|GO:0005773|GO:0071417|GO:0006887|GO:0051347|GO:0036211|GO:0070201|GO:0042060|GO:0046907|GO:0006954|GO:0050714|GO:0045576|GO:0051251|GO:0050715|GO:0022407|GO:0051046|GO:0031098|GO:0043434|GO:0007599|GO:0044344|GO:0007018|GO:0007159|GO:0009306|GO:0051247|GO:0070848|GO:0002764|GO:0006461|GO:0050663|GO:0032270|GO:0042110|GO:0006796|GO:0035556|GO:0044267|GO:0032609|GO:0031406|GO:0051174|GO:0032990|GO:0032725|GO:0007399|GO:0046903|GO:0071310|GO:0097485|GO:0000139|GO:0051648|GO:0051246|GO:0030154|GO:0022409|GO:0032418|GO:0048858|GO:0050707|GO:0032729|GO:1902531|GO:0072384|GO:0032870|GO:0042803|GO:0045089|GO:0045088|GO:0032649|GO:0048666|GO:0030182|GO:0032680|GO:0002521|GO:0007411|GO:0070304|GO:0045055|GO:0031401|GO:0050863|GO:0008543|GO:0032816|GO:0051259|GO:1901653|GO:0043408|GO:0000323|GO:1902715|GO:0047496|GO:0030217|GO:0050708|GO:0071363|GO:0043087|GO:0016310|GO:0033089|GO:0045619|GO:0002768|GO:0038179|GO:0072643|GO:0034112|GO:0070371|GO:0005509|GO:0032640|GO:0070486|GO:0061564|GO:0048017|GO:0043547|GO:0007167|GO:0033081|GO:0002715|GO:0001779|GO:0071375|GO:0002448|GO:0032252|GO:0043410|GO:0032872|GO:0033077|GO:0046914|GO:0016597|GO:0032868|GO:0051057|GO:0002717|GO:0032760|GO:0014066|GO:0051056|GO:0022008|GO:0048667|GO:0007264|GO:0006464|GO:0050870|GO:0030705|GO:0048812|GO:0045621|GO:0051403|GO:0043549|GO:1903039|GO:0033674|GO:0048011|GO:0045582|GO:0000186|GO:0007265|GO:0046578|GO:0045859|GO:0048015|GO:0045860|GO:0043406|GO:0090630|GO:0046328|GO:0007409|GO:0005764|GO:0032825|GO:0006468|GO:0048699|GO:0045580|GO:0046579|GO:0043405|GO:0042325|GO:0070374|GO:0007254|GO:0001932|GO:0032869|GO:0038093|GO:0032874|GO:0001934|GO:0070372|GO:0071593|GO:0008270|GO:0042327|GO:0007169|GO:0048010|GO:0046330|GO:0038095|GO:0071902|GO:0014065|GO:0071900|GO:0032147|GO:0008286|GO:0038127|GO:0042629|GO:0007173 locomotion|developmental process|immune system process|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|small molecule binding|cellular response to stimulus|regulation of cellular process|leukocyte activation|leukocyte mediated cytotoxicity|intracellular organelle|positive regulation of transport|response to stress|nuclear outer membrane-endoplasmic reticulum membrane network|organic substance metabolic process|ion binding|immune response|cellular metabolic process|cellular localization|regulation of signaling|anatomical structure morphogenesis|modified amino acid binding|cellular component organization|cell adhesion|membrane-bounded organelle|lipid binding|cell periphery|response to external stimulus|positive regulation of metabolic process|positive regulation of immune system process|natural killer cell mediated cytotoxicity|regulation of developmental process|intracellular|regulation of immune system process|immune system development|endoplasmic reticulum membrane|protein binding|plasma membrane|endomembrane system|guanyl-nucleotide exchange factor activity|anatomical structure development|organelle membrane|regulation of metabolic process|identical protein binding|regulation of cellular localization|regulation of hemopoiesis|phosphatidylcholine binding|coagulation|single organismal cell-cell adhesion|chemotaxis|innate immune response|regulation of cell differentiation|organelle localization|cell development|positive regulation of cell activation|transport|multicellular organism development|animal organ development|T cell aggregation|anion binding|secretion by cell|defense response|regulation of cell adhesion|phospholipid binding|positive regulation of cellular metabolic process|cellular response to stress|cellular component assembly|regulation of cytokine production|cell-cell adhesion|positive regulation of cell differentiation|intracellular membrane-bounded organelle|alcohol binding|inflammatory response to antigenic stimulus|cation binding|response to organonitrogen compound|cytoplasm|cytokine production|regulation of leukocyte mediated cytotoxicity|positive regulation of leukocyte mediated cytotoxicity|response to wounding|regulation of protein localization|regulation of natural killer cell mediated cytotoxicity|positive regulation of protein transport|Ras guanyl-nucleotide exchange factor activity|movement of cell or subcellular component|establishment of organelle localization|organic acid binding|diacylglycerol binding|positive regulation of leukocyte activation|cell activation|regulation of signal transduction|protein dimerization activity|cell activation involved in immune response|establishment of protein localization|positive regulation of cytokine production|regulation of cell communication|positive regulation of catalytic activity|regulation of immune response|protein localization|lymphocyte activation|regulation of cell activation|phosphatidylserine binding|cell communication|establishment of localization by movement along microtubule|signal transduction|leukocyte activation involved in immune response|positive regulation of immune response|endoplasmic reticulum|establishment of localization in cell|positive regulation of cell adhesion|response to hormone|positive regulation of secretion|regulation of catalytic activity|cell projection organization|leukocyte degranulation|cellular developmental process|positive regulation of signal transduction|positive regulation of natural killer cell mediated cytotoxicity|microtubule-based process|protein metabolic process|signal transduction by protein phosphorylation|response to organic substance|regulation of cellular metabolic process|regulation of body fluid levels|Golgi apparatus|leukocyte mediated immunity|response to fibroblast growth factor|MAPK cascade|vesicle-mediated transport|positive regulation of intracellular signal transduction|establishment of vesicle localization|regulation of lymphocyte activation|regulation of cellular protein metabolic process|cell morphogenesis|cytosol|neuron projection development|platelet activation|natural killer cell activation|metal ion binding|cell surface receptor signaling pathway|macromolecule modification|hemopoiesis|lymphocyte differentiation|positive regulation of hydrolase activity|blood coagulation|mast cell degranulation|homotypic cell-cell adhesion|regulation of protein transport|protein transport|response to peptide|natural killer cell mediated immunity|cell morphogenesis involved in differentiation|vacuole|cellular response to organonitrogen compound|exocytosis|positive regulation of transferase activity|protein modification process|regulation of establishment of protein localization|wound healing|intracellular transport|inflammatory response|positive regulation of protein secretion|mast cell activation|positive regulation of lymphocyte activation|positive regulation of cytokine secretion|regulation of cell-cell adhesion|regulation of secretion|stress-activated protein kinase signaling cascade|response to peptide hormone|hemostasis|cellular response to fibroblast growth factor stimulus|microtubule-based movement|leukocyte cell-cell adhesion|protein secretion|positive regulation of protein metabolic process|response to growth factor|immune response-regulating signaling pathway|protein complex assembly|cytokine secretion|positive regulation of cellular protein metabolic process|T cell activation|phosphate-containing compound metabolic process|intracellular signal transduction|cellular protein metabolic process|interferon-gamma production|carboxylic acid binding|regulation of phosphorus metabolic process|cell part morphogenesis|positive regulation of granulocyte macrophage colony-stimulating factor production|nervous system development|secretion|cellular response to organic substance|neuron projection guidance|Golgi membrane|vesicle localization|regulation of protein metabolic process|cell differentiation|positive regulation of cell-cell adhesion|lysosome localization|cell projection morphogenesis|regulation of cytokine secretion|positive regulation of interferon-gamma production|regulation of intracellular signal transduction|organelle transport along microtubule|cellular response to hormone stimulus|protein homodimerization activity|positive regulation of innate immune response|regulation of innate immune response|regulation of interferon-gamma production|neuron development|neuron differentiation|regulation of tumor necrosis factor production|leukocyte differentiation|axon guidance|positive regulation of stress-activated protein kinase signaling cascade|regulated exocytosis|positive regulation of protein modification process|regulation of T cell activation|fibroblast growth factor receptor signaling pathway|positive regulation of natural killer cell activation|protein oligomerization|cellular response to peptide|regulation of MAPK cascade|lytic vacuole|positive regulation of interferon-gamma secretion|vesicle transport along microtubule|T cell differentiation|regulation of protein secretion|cellular response to growth factor stimulus|regulation of GTPase activity|phosphorylation|positive regulation of T cell differentiation in thymus|regulation of lymphocyte differentiation|immune response-regulating cell surface receptor signaling pathway|neurotrophin signaling pathway|interferon-gamma secretion|positive regulation of homotypic cell-cell adhesion|ERK1 and ERK2 cascade|calcium ion binding|tumor necrosis factor production|leukocyte aggregation|axon development|inositol lipid-mediated signaling|positive regulation of GTPase activity|enzyme linked receptor protein signaling pathway|regulation of T cell differentiation in thymus|regulation of natural killer cell mediated immunity|natural killer cell differentiation|cellular response to peptide hormone stimulus|mast cell mediated immunity|secretory granule localization|positive regulation of MAPK cascade|regulation of stress-activated MAPK cascade|T cell differentiation in thymus|transition metal ion binding|amino acid binding|response to insulin|positive regulation of small GTPase mediated signal transduction|positive regulation of natural killer cell mediated immunity|positive regulation of tumor necrosis factor production|regulation of phosphatidylinositol 3-kinase signaling|regulation of small GTPase mediated signal transduction|neurogenesis|cell morphogenesis involved in neuron differentiation|small GTPase mediated signal transduction|cellular protein modification process|positive regulation of T cell activation|cytoskeleton-dependent intracellular transport|neuron projection morphogenesis|positive regulation of lymphocyte differentiation|stress-activated MAPK cascade|regulation of kinase activity|positive regulation of leukocyte cell-cell adhesion|positive regulation of kinase activity|neurotrophin TRK receptor signaling pathway|positive regulation of T cell differentiation|activation of MAPKK activity|Ras protein signal transduction|regulation of Ras protein signal transduction|regulation of protein kinase activity|phosphatidylinositol-mediated signaling|positive regulation of protein kinase activity|positive regulation of MAP kinase activity|activation of GTPase activity|regulation of JNK cascade|axonogenesis|lysosome|positive regulation of natural killer cell differentiation|protein phosphorylation|generation of neurons|regulation of T cell differentiation|positive regulation of Ras protein signal transduction|regulation of MAP kinase activity|regulation of phosphorylation|positive regulation of ERK1 and ERK2 cascade|JNK cascade|regulation of protein phosphorylation|cellular response to insulin stimulus|Fc receptor signaling pathway|positive regulation of stress-activated MAPK cascade|positive regulation of protein phosphorylation|regulation of ERK1 and ERK2 cascade|lymphocyte aggregation|zinc ion binding|positive regulation of phosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway|vascular endothelial growth factor receptor signaling pathway|positive regulation of JNK cascade|Fc-epsilon receptor signaling pathway|positive regulation of protein serine/threonine kinase activity|phosphatidylinositol 3-kinase signaling|regulation of protein serine/threonine kinase activity|activation of protein kinase activity|insulin receptor signaling pathway|ERBB signaling pathway|mast cell granule|epidermal growth factor receptor signaling pathway K04350 RAS guanyl-releasing protein 1[-] hsa05200|hsa04010|hsa04014|hsa04611|hsa04660 Pathways in cancer - Homo sapiens (human)|MAPK signaling pathway - Homo sapiens (human)|Ras signaling pathway - Homo sapiens (human)|Platelet activation - Homo sapiens (human)|T cell receptor signaling pathway - Homo sapiens (human) 15:38488103-38565575 16 16 14 6 12 4 0.103682967031838 0.0942283650847482 0.0817966954886395 0.0348374052437714 0.0638025031392051 0.0242893900248142 0.0932360092017419 0.0409764328025969 1.18609285763546 0.0123081363037098 0.0494412138335514 UP ENSG00000217258 AC007249.3 - - - - - - - 2:10452319-10455552 1 5 2 0 0 0 0.143252415835251 0.650742783508537 0.2582107368288 0 0 0 0.350735312057529 0 Inf 0.0123285387296391 0.049509846009503 UP ENSG00000213057 C1orf220 chromosome 1 open reading frame 220 [Source:HGNC Symbol;Acc:HGNC:33805] - - - - - - 1:178542752-178548889 28 18 14 48 38 50 0.628165564065182 0.367006481897637 0.283188305725972 0.964843859405003 0.69948389046066 1.05128777969817 0.426120117229597 0.905205176521278 -1.08698467175657 0.0123464333143591 0.0495683728035069 DOWN ENSG00000099365 STX1B syntaxin 1B [Source:HGNC Symbol;Acc:HGNC:18539] GO:0032991|GO:0045202|GO:0023052|GO:0005623|GO:0016020|GO:0009987|GO:0008152|GO:0050896|GO:0005488|GO:0031629|GO:0051716|GO:0008021|GO:0050794|GO:0043229|GO:0051050|GO:0016079|GO:0071704|GO:0051641|GO:0023051|GO:0016043|GO:0043227|GO:0071944|GO:0031224|GO:0016082|GO:0005622|GO:0007269|GO:0005515|GO:0005886|GO:0043234|GO:0016081|GO:0012505|GO:0019222|GO:0060341|GO:0031201|GO:0050804|GO:0042391|GO:0051640|GO:0006810|GO:0060627|GO:0032940|GO:0001956|GO:0061669|GO:0031982|GO:0051128|GO:0050806|GO:0022607|GO:0043231|GO:0030133|GO:0019899|GO:0005737|GO:0007267|GO:0051656|GO:0022406|GO:0009966|GO:0005484|GO:0045184|GO:0010807|GO:0019904|GO:0010646|GO:0000149|GO:0008104|GO:0007154|GO:0061024|GO:0007165|GO:0051649|GO:0001505|GO:2000300|GO:0051047|GO:0016021|GO:0009967|GO:0043254|GO:0006996|GO:0046928|GO:0061025|GO:0016192|GO:0006836|GO:0051650|GO:0005829|GO:0048278|GO:2000463|GO:0010468|GO:0016050|GO:0007166|GO:0031410|GO:0005815|GO:0032386|GO:0060078|GO:0015031|GO:0048489|GO:0016023|GO:0006887|GO:0070382|GO:0046907|GO:0017157|GO:1902803|GO:0051046|GO:0031988|GO:0006461|GO:0034613|GO:0019900|GO:0010467|GO:0046903|GO:0098815|GO:0051648|GO:0005856|GO:0005634|GO:0005819|GO:0048284|GO:0045055|GO:0006904|GO:0034622|GO:0045026|GO:0043623|GO:0016482|GO:0006886|GO:0006906|GO:0015630|GO:1903305|GO:0060079|GO:0019901|GO:0017156|GO:0017158|GO:0007268 macromolecular complex|synapse|signaling|cell|membrane|cellular process|metabolic process|response to stimulus|binding|synaptic vesicle fusion to presynaptic active zone membrane|cellular response to stimulus|synaptic vesicle|regulation of cellular process|intracellular organelle|positive regulation of transport|synaptic vesicle exocytosis|organic substance metabolic process|cellular localization|regulation of signaling|cellular component organization|membrane-bounded organelle|cell periphery|intrinsic component of membrane|synaptic vesicle priming|intracellular|neurotransmitter secretion|protein binding|plasma membrane|protein complex|synaptic vesicle docking|endomembrane system|regulation of metabolic process|regulation of cellular localization|SNARE complex|modulation of synaptic transmission|regulation of membrane potential|organelle localization|transport|regulation of vesicle-mediated transport|secretion by cell|positive regulation of neurotransmitter secretion|spontaneous neurotransmitter secretion|vesicle|regulation of cellular component organization|positive regulation of synaptic transmission|cellular component assembly|intracellular membrane-bounded organelle|transport vesicle|enzyme binding|cytoplasm|cell-cell signaling|establishment of organelle localization|membrane docking|regulation of signal transduction|SNAP receptor activity|establishment of protein localization|regulation of synaptic vesicle priming|protein domain specific binding|regulation of cell communication|SNARE binding|protein localization|cell communication|membrane organization|signal transduction|establishment of localization in cell|regulation of neurotransmitter levels|regulation of synaptic vesicle exocytosis|positive regulation of secretion|integral component of membrane|positive regulation of signal transduction|regulation of protein complex assembly|organelle organization|regulation of neurotransmitter secretion|membrane fusion|vesicle-mediated transport|neurotransmitter transport|establishment of vesicle localization|cytosol|vesicle docking|positive regulation of excitatory postsynaptic potential|regulation of gene expression|vesicle organization|cell surface receptor signaling pathway|cytoplasmic vesicle|microtubule organizing center|regulation of intracellular transport|regulation of postsynaptic membrane potential|protein transport|synaptic vesicle transport|cytoplasmic, membrane-bounded vesicle|exocytosis|exocytic vesicle|intracellular transport|regulation of exocytosis|regulation of synaptic vesicle transport|regulation of secretion|membrane-bounded vesicle|protein complex assembly|cellular protein localization|kinase binding|gene expression|secretion|modulation of excitatory postsynaptic potential|vesicle localization|cytoskeleton|nucleus|spindle|organelle fusion|regulated exocytosis|vesicle docking involved in exocytosis|cellular macromolecular complex assembly|plasma membrane fusion|cellular protein complex assembly|cytosolic transport|intracellular protein transport|vesicle fusion|microtubule cytoskeleton|regulation of regulated secretory pathway|excitatory postsynaptic potential|protein kinase binding|calcium ion regulated exocytosis|regulation of calcium ion-dependent exocytosis|synaptic transmission K08486 syntaxin 1B/2/3[-] hsa04721|hsa04130 Synaptic vesicle cycle - Homo sapiens (human)|SNARE interactions in vesicular transport - Homo sapiens (human) 16:30989256-31010628 7 11 12 22 18 31 0.0505583082613441 0.0722065292554252 0.0781434167817605 0.142364165727825 0.106664603402785 0.209836652410748 0.0669694180995099 0.152955140513786 -1.19153425621086 0.0123490673697875 0.0495722814653269 DOWN ENSG00000224939 LINC00184 long intergenic non-protein coding RNA 184 [Source:HGNC Symbol;Acc:HGNC:37192] - - - - - - 1:234629311-234634780 3 3 3 11 10 9 0.0934950745898432 0.084974595107964 0.0842734721644368 0.30711776192474 0.255682727069512 0.262837984647517 0.0875810472874147 0.275212824547256 -1.65185709261134 0.0123519825925021 0.0495773176010429 DOWN